locus-tag	class	description
K6749_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K6749_00010	COG0592	DNA-directed DNA polymerase activity
K6749_00020	COG0187	DNA topoisomerase II activity
K6749_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
K6749_00035	COG3977	Valine--pyruvate aminotransferase
K6749_00040	COG0366	Alpha amylase catalytic
K6749_00055	COG2119	membrane
K6749_00065	COG0425	Belongs to the sulfur carrier protein TusA family
K6749_00080	COG0604	alcohol dehydrogenase
K6749_00085	COG0183	Belongs to the thiolase family
K6749_00095	COG1739	Uncharacterized protein family UPF0029
K6749_00100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6749_00140	COG0583	DNA-binding transcription factor activity
K6749_00145	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K6749_00150	COG2960	long-chain fatty acid transporting porin activity
K6749_00155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6749_00160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6749_00215	COG4166	transmembrane transport
K6749_00220	COG0601	transmembrane transport
K6749_00225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6749_00260	COG1609	Transcriptional regulator
K6749_00265	COG0583	DNA-binding transcription factor activity
K6749_00280	COG0129	dihydroxy-acid dehydratase activity
K6749_00285	COG3265	gluconokinase activity
K6749_00290	COG2610	gluconate transmembrane transporter activity
K6749_00295	COG0800	Aldolase
K6749_00300	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K6749_00305	COG0583	DNA-binding transcription factor activity
K6749_00310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6749_00315	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K6749_00325	COG1522	sequence-specific DNA binding
K6749_00330	COG5001	Diguanylate cyclase
K6749_00330	COG5002	protein histidine kinase activity
K6749_00335	COG0742	ribosomal rna small subunit methyltransferase
K6749_00350	COG0589	response to stress
K6749_00355	COG1528	Iron-storage protein
K6749_00365	COG2081	HI0933 family
K6749_00395	COG1597	lipid kinase activity
K6749_00425	COG0628	permease
K6749_00440	COG1322	Protein conserved in bacteria
K6749_00445	COG2226	methyltransferase
K6749_00450	COG3165	ubiquinone biosynthetic process from chorismate
K6749_00455	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K6749_00465	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K6749_00470	COG0805	protein transport
K6749_00475	COG0084	hydrolase, TatD family'
K6749_00485	COG0456	acetyltransferase
K6749_00490	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6749_00490	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6749_00495	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K6749_00525	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K6749_00535	COG2204	response regulator
K6749_00540	COG3852	Histidine kinase
K6749_00550	COG0174	glutamine synthetase
K6749_00555	COG1217	gtp-binding protein TYPA
K6749_00560	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K6749_00570	COG1295	ribonuclease BN
K6749_00575	COG1490	D-aminoacyl-tRNA deacylase activity
K6749_00580	COG0456	acetyltransferase
K6749_00590	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K6749_00595	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K6749_00600	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K6749_00605	COG3031	protein transport across the cell outer membrane
K6749_00615	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K6749_00620	COG1459	type II secretion system
K6749_00625	COG2165	general secretion pathway protein
K6749_00630	COG2165	general secretion pathway protein
K6749_00635	COG2165	general secretion pathway protein
K6749_00640	COG4795	General secretion pathway protein
K6749_00645	COG3156	type II secretion system protein K
K6749_00650	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K6749_00655	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K6749_00665	COG1218	3'(2'),5'-bisphosphate nucleotidase
K6749_00670	COG0494	nUDIX hydrolase
K6749_00680	COG1040	competence protein
K6749_00695	COG2183	response to ionizing radiation
K6749_00705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6749_00725	COG2233	PERMEase
K6749_00730	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K6749_00735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6749_00740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K6749_00745	COG1758	RNA polymerase activity
K6749_00750	COG0194	GDP metabolic process
K6749_00765	COG0848	biopolymer transport protein
K6749_00770	COG0811	peptide transport
K6749_00790	COG4174	ABC transporter (Permease)
K6749_00795	COG4239	(ABC) transporter, permease
K6749_00800	COG0747	negative chemotaxis
K6749_00805	COG0444	Belongs to the ABC transporter superfamily
K6749_00810	COG4608	Belongs to the ABC transporter superfamily
K6749_00820	COG1561	YicC-like family, N-terminal region
K6749_00825	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K6749_00830	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K6749_00835	COG1560	Kdo2-lipid A biosynthetic process
K6749_00840	COG1309	transcriptional regulator
K6749_00845	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K6749_00855	COG2003	Belongs to the UPF0758 family
K6749_00880	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K6749_00895	COG0463	Glycosyl transferase, family 2
K6749_00900	COG0859	PFAM glycosyl transferase family 9
K6749_00905	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K6749_00910	COG3642	lipopolysaccharide core region biosynthetic process
K6749_00920	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K6749_00960	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K6749_00965	COG1519	Transferase
K6749_00970	COG0859	PFAM glycosyl transferase family 9
K6749_00980	COG1560	Kdo2-lipid A biosynthetic process
K6749_00990	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6749_01040	COG1216	Glycosyl transferase, family 2
K6749_01040	COG0463	Glycosyl transferase, family 2
K6749_01055	COG1215	transferase activity, transferring glycosyl groups
K6749_01060	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6749_01065	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K6749_01070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6749_01090	COG0438	transferase activity, transferring glycosyl groups
K6749_01130	COG0149	triose-phosphate isomerase activity
K6749_01160	COG1494	fructose-1,6-bisphosphatase
K6749_01170	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K6749_01175	COG1575	Belongs to the MenA family. Type 1 subfamily
K6749_01180	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K6749_01185	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K6749_01195	COG1609	Transcriptional regulator
K6749_01200	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K6749_01205	COG0254	rRNA binding
K6749_01215	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K6749_01220	COG0088	Forms part of the polypeptide exit tunnel
K6749_01230	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K6749_01235	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K6749_01240	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K6749_01245	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K6749_01255	COG0255	Belongs to the universal ribosomal protein uL29 family
K6749_01260	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K6749_01270	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K6749_01275	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K6749_01285	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K6749_01290	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K6749_01305	COG1841	ribosomal large subunit assembly
K6749_01310	COG0200	Binds to the 23S rRNA
K6749_01315	COG0201	protein transport
K6749_01320	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K6749_01325	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K6749_01330	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K6749_01340	COG0202	RNA polymerase activity
K6749_01345	COG0203	ribosomal protein L17
K6749_01355	COG0545	Peptidyl-prolyl cis-trans isomerase
K6749_01365	COG2153	protein acetylation
K6749_01370	COG0513	Belongs to the DEAD box helicase family
K6749_01385	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K6749_01385	COG1648	precorrin-2 dehydrogenase activity
K6749_01390	COG0175	sulfate reduction
K6749_01395	COG2895	sulfate adenylyltransferase (ATP) activity
K6749_01400	COG0471	metal ion transport
K6749_01400	COG3273	potassium ion transport
K6749_01405	COG0529	Catalyzes the synthesis of activated sulfate
K6749_01425	COG4181	ATPase activity
K6749_01440	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K6749_01450	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6749_01455	COG0729	surface antigen
K6749_01460	COG2911	Protein conserved in bacteria
K6749_01465	COG2105	PFAM AIG2 family protein
K6749_01475	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K6749_01480	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K6749_01485	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K6749_01490	COG0163	prenyltransferase activity
K6749_01495	COG4143	(ABC) transporter
K6749_01500	COG1178	ABC-type Fe3 transport system permease component
K6749_01505	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K6749_01510	COG0583	DNA-binding transcription factor activity
K6749_01515	COG1902	pentaerythritol trinitrate reductase activity
K6749_01530	COG2358	TRAP transporter, solute receptor (TAXI family
K6749_01550	COG0142	geranyltranstransferase activity
K6749_01555	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K6749_01565	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K6749_01570	COG2966	Psort location CytoplasmicMembrane, score
K6749_01580	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K6749_01585	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K6749_01590	COG2967	ApaG domain
K6749_01595	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K6749_01600	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K6749_01605	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6749_01610	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K6749_01615	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K6749_01635	COG0473	3-isopropylmalate dehydrogenase activity
K6749_01640	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K6749_01660	COG0583	DNA-binding transcription factor activity
K6749_01665	COG1022	Amp-dependent synthetase and ligase
K6749_01670	COG0028	Belongs to the TPP enzyme family
K6749_01675	COG0440	acetolactate synthase activity
K6749_01690	COG0469	pyruvate kinase activity
K6749_01695	COG1349	DNA-binding transcription factor activity
K6749_01700	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K6749_01710	COG2376	Dihydroxyacetone kinase
K6749_01715	COG1461	Dihydroxyacetone kinase
K6749_01730	COG3722	fumarate hydratase activity
K6749_01740	COG2213	PTS system mannitol-specific
K6749_01740	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6749_01775	COG0358	DNA primase activity
K6749_01780	COG1610	YqeY-like protein
K6749_01785	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K6749_01790	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K6749_01795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K6749_01800	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K6749_01805	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K6749_01810	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K6749_01815	COG1968	undecaprenyl-diphosphatase activity
K6749_01825	COG3409	Peptidoglycan-binding domain 1 protein
K6749_01825	COG3267	Type II secretory pathway component ExeA
K6749_01835	COG0405	Gamma-glutamyltransferase
K6749_01840	COG4991	sh3 domain protein
K6749_01845	COG0306	phosphate transporter
K6749_01850	COG1392	Phosphate transport regulator
K6749_01855	COG3025	triphosphatase activity
K6749_01870	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K6749_01875	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K6749_01875	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K6749_01880	COG1538	Outer membrane efflux protein
K6749_01885	COG0494	nUDIX hydrolase
K6749_01890	COG3151	Protein conserved in bacteria
K6749_01900	COG3150	esterase
K6749_01910	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K6749_01915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6749_01925	COG3105	Protein conserved in bacteria
K6749_01930	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K6749_01940	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K6749_01945	COG0723	plastoquinol--plastocyanin reductase activity
K6749_01950	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K6749_01955	COG2857	Cytochrome c1
K6749_01960	COG0625	glutathione transferase activity
K6749_01965	COG2969	positive regulation of protein catabolic process
K6749_01970	COG2823	Periplasmic or secreted lipoprotein
K6749_01975	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K6749_01990	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K6749_02005	COG3116	cell division
K6749_02010	COG0768	penicillin binding
K6749_02015	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K6749_02020	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K6749_02025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6749_02030	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K6749_02035	COG0772	Belongs to the SEDS family
K6749_02050	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K6749_02055	COG0849	cell division
K6749_02060	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K6749_02065	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K6749_02075	COG0653	protein targeting
K6749_02080	COG0494	nUDIX hydrolase
K6749_02090	COG0505	Belongs to the CarA family
K6749_02095	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K6749_02105	COG0730	response to heat
K6749_02110	COG0583	DNA-binding transcription factor activity
K6749_02115	COG2860	membrane
K6749_02130	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K6749_02140	COG0493	'glutamate synthase
K6749_02145	COG0070	glutamate synthase
K6749_02145	COG0069	glutamate synthase activity
K6749_02145	COG0067	glutamate synthase
K6749_02155	COG0070	glutamate synthase
K6749_02155	COG0067	glutamate synthase
K6749_02155	COG0069	glutamate synthase activity
K6749_02160	COG1242	4 iron, 4 sulfur cluster binding
K6749_02165	COG2203	Gaf domain
K6749_02165	COG3706	GGDEF domain
K6749_02165	COG4251	negative regulation of phosphorylation
K6749_02165	COG5001	Diguanylate cyclase
K6749_02170	COG0784	Response regulator, receiver
K6749_02170	COG5002	protein histidine kinase activity
K6749_02170	COG2198	Histidine kinase
K6749_02180	COG0745	RESPONSE REGULATOR receiver
K6749_02190	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K6749_02210	COG0083	homoserine kinase activity
K6749_02215	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K6749_02225	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
K6749_02230	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K6749_02235	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K6749_02250	COG1115	amino acid carrier protein
K6749_02255	COG3022	response to hydroperoxide
K6749_02260	COG0513	Belongs to the DEAD box helicase family
K6749_02265	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K6749_02275	COG0716	FMN binding
K6749_02280	COG4974	Belongs to the 'phage' integrase family
K6749_02285	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K6749_02290	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K6749_02305	COG2204	response regulator
K6749_02315	COG0667	Aldo Keto reductase
K6749_02340	COG0730	response to heat
K6749_02345	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K6749_02350	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K6749_02360	COG1283	sodium-dependent phosphate transmembrane transporter activity
K6749_02365	COG0583	DNA-binding transcription factor activity
K6749_02370	COG0640	Transcriptional regulator
K6749_02375	COG0268	Binds directly to 16S ribosomal RNA
K6749_02380	COG0728	peptidoglycan biosynthetic process
K6749_02385	COG0196	riboflavin kinase activity
K6749_02400	COG1047	Peptidyl-prolyl cis-trans
K6749_02405	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K6749_02415	COG3279	Response regulator of the LytR AlgR family
K6749_02420	COG3275	phosphorelay sensor kinase activity
K6749_02425	COG1966	Carbon starvation protein
K6749_02445	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K6749_02450	COG1472	Belongs to the glycosyl hydrolase 3 family
K6749_02455	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K6749_02460	COG0287	Prephenate dehydrogenase
K6749_02460	COG1605	Chorismate mutase
K6749_02465	COG0739	heme binding
K6749_02475	COG0488	(ABC) transporter
K6749_02485	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
K6749_02490	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
K6749_02495	COG0077	Prephenate dehydratase
K6749_02495	COG1605	Chorismate mutase
K6749_02500	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K6749_02510	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6749_02515	COG0564	pseudouridine synthase activity
K6749_02525	COG0542	response to heat
K6749_02580	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K6749_02585	COG0826	peptidase U32
K6749_02590	COG2974	May be involved in recombination
K6749_02595	COG0745	RESPONSE REGULATOR receiver
K6749_02600	COG5002	protein histidine kinase activity
K6749_02610	COG0248	Ppx GppA phosphatase
K6749_02615	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K6749_02620	COG0573	inorganic phosphate transmembrane transporter activity
K6749_02625	COG0581	inorganic phosphate transmembrane transporter activity
K6749_02630	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K6749_02635	COG0704	Plays a role in the regulation of phosphate uptake
K6749_02645	COG3142	Participates in the control of copper homeostasis
K6749_02650	COG0450	alkyl hydroperoxide reductase
K6749_02655	COG0583	DNA-binding transcription factor activity
K6749_02660	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K6749_02670	COG0517	IMP dehydrogenase activity
K6749_02680	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K6749_02690	COG1862	Preprotein translocase
K6749_02695	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6749_02700	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6749_02715	COG0483	inositol monophosphate 1-phosphatase activity
K6749_02720	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
K6749_02730	COG1104	cysteine desulfurase activity
K6749_02735	COG0822	iron-sulfur transferase activity
K6749_02750	COG0443	Heat shock 70 kDa protein
K6749_02755	COG0633	Ferredoxin
K6749_02760	COG2975	iron-sulfur cluster assembly
K6749_02770	COG0105	UTP biosynthetic process
K6749_02785	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K6749_02790	COG0124	histidyl-tRNA synthetase
K6749_02795	COG2976	Protein conserved in bacteria
K6749_02800	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6749_02805	COG1160	GTP binding
K6749_02825	COG0517	IMP dehydrogenase activity
K6749_02825	COG0516	GMP reductase activity
K6749_02835	COG1757	Na H antiporter
K6749_02845	COG1584	GPR1 FUN34 yaaH family protein
K6749_02850	COG1115	amino acid carrier protein
K6749_02865	COG2873	o-acetylhomoserine
K6749_02870	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K6749_02890	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6749_02890	COG3153	acetyltransferase
K6749_02895	COG0583	DNA-binding transcription factor activity
K6749_02915	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K6749_02920	COG2867	negative regulation of translational initiation
K6749_02925	COG2914	Belongs to the UPF0125 (RnfH) family
K6749_02930	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6749_02940	COG0497	DNA recombination
K6749_02950	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K6749_02955	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K6749_02960	COG1301	dicarboxylic acid transport
K6749_02970	COG0484	heat shock protein binding
K6749_02980	COG4969	Belongs to the N-Me-Phe pilin family
K6749_03000	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K6749_03010	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K6749_03015	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K6749_03015	COG0047	phosphoribosylformylglycinamidine synthase activity
K6749_03045	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6749_03050	COG2252	PERMEase
K6749_03055	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K6749_03060	COG1073	alpha beta
K6749_03070	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K6749_03075	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K6749_03080	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K6749_03085	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6749_03085	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6749_03100	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K6749_03110	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K6749_03115	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K6749_03120	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K6749_03125	COG0142	geranyltranstransferase activity
K6749_03130	COG1722	exodeoxyribonuclease VII activity
K6749_03135	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K6749_03145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6749_03145	COG0301	tRNA thio-modification
K6749_03150	COG0583	DNA-binding transcription factor activity
K6749_03160	COG2363	Small membrane protein
K6749_03170	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6749_03175	COG1611	Belongs to the LOG family
K6749_03190	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K6749_03190	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K6749_03200	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
K6749_03205	COG1464	Belongs to the NlpA lipoprotein family
K6749_03210	COG2011	ABC-type metal ion transport system permease component
K6749_03215	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K6749_03220	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K6749_03230	COG1263	PTS System
K6749_03230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6749_03235	COG0366	Alpha amylase catalytic
K6749_03250	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6749_03255	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K6749_03260	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K6749_03265	COG0321	lipoyl(octanoyl) transferase activity
K6749_03275	COG1686	Belongs to the peptidase S11 family
K6749_03280	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K6749_03285	COG0772	Belongs to the SEDS family
K6749_03290	COG0768	penicillin binding
K6749_03295	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K6749_03300	COG0799	negative regulation of ribosome biogenesis
K6749_03305	COG1466	dna polymerase III delta subunit
K6749_03310	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
K6749_03315	COG0495	leucyl-tRNA aminoacylation
K6749_03320	COG2888	peptidyl-tyrosine sulfation
K6749_03325	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K6749_03330	COG4535	Mg2 and Co2 transporter CorC
K6749_03335	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K6749_03340	COG1702	phosphate starvation-inducible protein PhoH
K6749_03345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K6749_03350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6749_03455	COG0012	GTP binding
K6749_03460	COG0193	aminoacyl-tRNA hydrolase activity
K6749_03465	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K6749_03470	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K6749_03475	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K6749_03480	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K6749_03490	COG2890	protein-(glutamine-N5) methyltransferase activity
K6749_03495	COG3094	Invasion gene expression up-regulator, SirB
K6749_03500	COG2912	Transglutaminase-like superfamily
K6749_03505	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K6749_03510	COG0737	Belongs to the 5'-nucleotidase family
K6749_03515	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K6749_03520	COG1187	pseudouridine synthase activity
K6749_03525	COG2840	Smr protein MutS2
K6749_03565	COG2217	Heavy metal translocating P-type atpase
K6749_03565	COG2608	mercury ion transmembrane transporter activity
K6749_03575	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K6749_03630	COG0835	chemotaxis
K6749_03630	COG0784	Response regulator, receiver
K6749_03635	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K6749_03640	COG1815	bacterial-type flagellum-dependent cell motility
K6749_03645	COG1558	bacterial-type flagellum-dependent cell motility
K6749_03655	COG1749	Flagellar hook protein flgE
K6749_03660	COG4787	bacterial-type flagellum-dependent cell motility
K6749_03670	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K6749_03675	COG1706	bacterial-type flagellum-dependent cell motility
K6749_03680	COG3951	Flagellar rod assembly protein muramidase FlgJ
K6749_03680	COG1705	Flagellar rod assembly protein muramidase FlgJ
K6749_03690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6749_03695	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6749_03700	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6749_03705	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6749_03710	COG2190	(PTS) system
K6749_03715	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K6749_03720	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6749_03725	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6749_03730	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
K6749_03735	COG3115	cell septum assembly
K6749_03740	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K6749_03765	COG0330	HflC and HflK could
K6749_03770	COG2194	sulfuric ester hydrolase activity
K6749_03790	COG1192	Involved in chromosome partitioning
K6749_03795	COG1215	transferase activity, transferring glycosyl groups
K6749_03805	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
K6749_03815	COG3118	belongs to the thioredoxin family
K6749_03820	COG0300	oxidoreductase activity
K6749_03825	COG1090	epimerase
K6749_03855	COG0622	Phosphoesterase
K6749_03875	COG3710	Transcriptional regulator
K6749_03880	COG0326	Molecular chaperone. Has ATPase activity
K6749_03890	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K6749_03895	COG3104	oligopeptide transport
K6749_03900	COG0250	Participates in transcription elongation, termination and antitermination
K6749_03905	COG0367	asparagine synthase
K6749_03910	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K6749_03910	COG4651	solute:proton antiporter activity
K6749_03915	COG1846	Transcriptional regulator
K6749_03915	COG1940	carbohydrate kinase activity
K6749_03920	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K6749_03925	COG2190	(PTS) system
K6749_03925	COG1263	PTS System
K6749_03925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6749_03930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K6749_03935	COG0735	belongs to the Fur family
K6749_03945	COG0716	FMN binding
K6749_03955	COG0596	Alpha beta hydrolase
K6749_03960	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
K6749_03965	COG0033	Phosphoglucomutase
K6749_03975	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K6749_03990	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K6749_03995	COG1053	succinate dehydrogenase
K6749_04000	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K6749_04005	COG0567	Dehydrogenase, E1 component
K6749_04010	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6749_04015	COG0045	succinate-CoA ligase (ADP-forming) activity
K6749_04025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K6749_04030	COG1121	(ABC) transporter
K6749_04035	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
K6749_04040	COG4977	sequence-specific DNA binding
K6749_04045	COG1918	ferrous iron import across plasma membrane
K6749_04070	COG0018	arginyl-trna synthetase
K6749_04075	COG3102	Protein conserved in bacteria
K6749_04090	COG0788	formyltetrahydrofolate deformylase activity
K6749_04095	COG1199	ATP-dependent helicase activity
K6749_04100	COG1214	PFAM Peptidase M22, glycoprotease
K6749_04110	COG3065	identical protein binding
K6749_04115	COG2267	carboxylic ester hydrolase activity
K6749_04120	COG0318	PFAM AMP-dependent synthetase and ligase
K6749_04125	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K6749_04130	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K6749_04135	COG2894	cell division
K6749_04140	COG0850	regulation of cytokinetic process
K6749_04145	COG3100	YcgL domain-containing protein
K6749_04150	COG2951	lytic endotransglycosylase activity
K6749_04160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6749_04165	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K6749_04175	COG2226	methyltransferase
K6749_04180	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K6749_04185	COG1028	Short-chain dehydrogenase reductase Sdr
K6749_04195	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K6749_04220	COG2986	histidine ammonia-lyase
K6749_04225	COG1216	Glycosyl transferase, family 2
K6749_04230	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K6749_04245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6749_04250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6749_04285	COG0513	Belongs to the DEAD box helicase family
K6749_04290	COG0569	domain protein
K6749_04295	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6749_04310	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K6749_04315	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K6749_04320	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K6749_04325	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K6749_04340	COG0544	peptidyl-prolyl cis-trans isomerase activity
K6749_04350	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K6749_04355	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K6749_04360	COG0776	regulation of translation
K6749_04365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6749_04370	COG1555	photosystem II stabilization
K6749_04385	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K6749_04390	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K6749_04395	COG0436	Aminotransferase
K6749_04400	COG1169	isochorismate synthase
K6749_04405	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K6749_04415	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K6749_04435	COG2855	membrane
K6749_04440	COG0477	Major facilitator Superfamily
K6749_04485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6749_04490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6749_04505	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6749_04510	COG1522	sequence-specific DNA binding
K6749_04520	COG1946	Acyl-CoA thioesterase
K6749_04525	COG3126	Type III secretion system lipoprotein chaperone (YscW)
K6749_04550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6749_04555	COG0517	IMP dehydrogenase activity
K6749_04555	COG0516	GMP reductase activity
K6749_04580	COG0537	adenosine 5'-monophosphoramidase activity
K6749_04605	COG3150	esterase
K6749_04610	COG1252	NADH dehydrogenase
K6749_04625	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K6749_04635	COG4591	ABC-type transport system involved in lipoprotein release permease component
K6749_04640	COG1136	(ABC) transporter
K6749_04645	COG4591	ABC-type transport system involved in lipoprotein release permease component
K6749_04655	COG0658	competence protein
K6749_04655	COG2333	competence protein COMEC
K6749_04660	COG1132	(ABC) transporter
K6749_04680	COG2719	SpoVR family
K6749_04685	COG2718	Belongs to the UPF0229 family
K6749_04690	COG2766	serine protein kinase
K6749_04695	COG3013	Belongs to the UPF0304 family
K6749_04705	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K6749_04715	COG1882	Formate acetyltransferase
K6749_04755	COG0708	Exodeoxyribonuclease III
K6749_04765	COG3923	Primosomal replication protein n
K6749_04770	COG0730	response to heat
K6749_04775	COG1199	ATP-dependent helicase activity
K6749_04780	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6749_04785	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K6749_04790	COG1187	pseudouridine synthase activity
K6749_04800	COG1278	Cold shock
K6749_04805	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K6749_04810	COG0542	response to heat
K6749_04815	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K6749_04820	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K6749_04825	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K6749_04845	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K6749_04850	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K6749_04855	COG0297	glycogen (starch) synthase activity
K6749_04875	COG3070	regulator of competence-specific genes
K6749_04880	COG1609	Transcriptional regulator
K6749_04885	COG3381	protein complex oligomerization
K6749_04890	COG0745	RESPONSE REGULATOR receiver
K6749_04895	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K6749_04900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K6749_04905	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
K6749_04910	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
K6749_04915	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K6749_04935	COG0189	ligase activity
K6749_04935	COG4067	protein conserved in archaea
K6749_04940	COG0500	methyltransferase
K6749_04950	COG1801	Protein of unknown function DUF72
K6749_04960	COG0217	transcriptional regulatory protein
K6749_04965	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K6749_04970	COG0632	four-way junction helicase activity
K6749_04975	COG2255	four-way junction helicase activity
K6749_04980	COG1271	oxidase subunit
K6749_04985	COG1294	oxidase, subunit
K6749_04990	COG4890	Cyd operon protein YbgT
K6749_05000	COG0824	Thioesterase
K6749_05005	COG0811	peptide transport
K6749_05020	COG0823	Involved in the tonB-independent uptake of proteins
K6749_05025	COG2885	chlorophyll binding
K6749_05030	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
K6749_05035	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K6749_05045	COG3766	membrane
K6749_05055	COG0754	glutathionylspermidine amidase activity
K6749_05065	COG0784	Response regulator, receiver
K6749_05065	COG5002	protein histidine kinase activity
K6749_05080	COG1294	oxidase, subunit
K6749_05085	COG1271	oxidase subunit
K6749_05105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6749_05110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6749_05135	COG3568	Endonuclease Exonuclease Phosphatase
K6749_05160	COG0583	DNA-binding transcription factor activity
K6749_05170	COG0686	Belongs to the AlaDH PNT family
K6749_05180	COG1674	ftsk spoiiie
K6749_05190	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K6749_05200	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K6749_05220	COG1073	alpha beta
K6749_05220	COG2226	methyltransferase
K6749_05225	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K6749_05245	COG0300	oxidoreductase activity
K6749_05260	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K6749_05270	COG2268	Band 7 protein
K6749_05280	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K6749_05285	COG2915	High frequency lysogenization protein hflD homolog
K6749_05300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6749_05310	COG1757	Na H antiporter
K6749_05320	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K6749_05330	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K6749_05330	COG0131	Imidazoleglycerol-phosphate dehydratase
K6749_05335	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K6749_05340	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K6749_05350	COG0140	phosphoribosyl-ATP diphosphatase activity
K6749_05350	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K6749_05355	COG3012	SEC-C Motif Domain Protein
K6749_05360	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K6749_05365	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6749_05370	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K6749_05375	COG0215	cysteine-tRNA ligase activity
K6749_05380	COG1435	thymidine kinase activity
K6749_05410	COG2116	formate transmembrane transporter activity
K6749_05420	COG0390	transport system, permease component
K6749_05425	COG4459	periplasmic nitrate reductase
K6749_05430	COG3005	denitrification pathway
K6749_05435	COG0243	molybdopterin cofactor binding
K6749_05450	COG1227	inorganic diphosphatase activity
K6749_05460	COG4172	Belongs to the ABC transporter superfamily
K6749_05470	COG4171	peptide transport system, permease
K6749_05485	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K6749_05490	COG1842	Phage shock protein A
K6749_05500	COG1983	PspC domain protein
K6749_05520	COG2818	Glycosylase
K6749_05525	COG5380	lipid catabolic process
K6749_05530	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
K6749_05535	COG0626	cystathionine gamma-synthase activity
K6749_05545	COG0733	neurotransmitter:sodium symporter activity
K6749_05550	COG0564	pseudouridine synthase activity
K6749_05560	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K6749_05565	COG1151	hydroxylamine reductase activity
K6749_05570	COG3604	Transcriptional regulator
K6749_05580	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K6749_05585	COG4136	ATPase activity
K6749_05590	COG4135	transport system, permease component
K6749_05595	COG4134	Bacterial extracellular solute-binding protein
K6749_05605	COG3313	Fe-S protein
K6749_05625	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K6749_05645	COG1061	Type III restriction enzyme res subunit
K6749_05650	COG1187	pseudouridine synthase activity
K6749_05655	COG2814	Major facilitator Superfamily
K6749_05665	COG0702	epimerase
K6749_05670	COG0534	Mate efflux family protein
K6749_05690	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K6749_05700	COG1960	acyl-CoA dehydrogenase activity
K6749_05705	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K6749_05710	COG2985	domain, Protein
K6749_05710	COG3273	potassium ion transport
K6749_05715	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K6749_05725	COG1737	Transcriptional regulator
K6749_05730	COG0076	glutamate decarboxylase activity
K6749_05740	COG2431	L-lysine efflux transmembrane transporter activity
K6749_05750	COG3070	regulator of competence-specific genes
K6749_05765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6749_05765	COG4191	Histidine kinase
K6749_05775	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K6749_05785	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K6749_05790	COG4988	ABC transporter
K6749_05795	COG0492	ferredoxin-NADP+ reductase activity
K6749_05820	COG0471	metal ion transport
K6749_05825	COG2949	membrane
K6749_05830	COG0281	malic enzyme
K6749_05835	COG1643	Atp-dependent helicase
K6749_05850	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K6749_05965	COG0277	FAD linked oxidase domain protein
K6749_05965	COG0247	lactate metabolic process
K6749_05980	COG2986	histidine ammonia-lyase
K6749_05985	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K6749_05990	COG0010	Belongs to the arginase family
K6749_05995	COG1228	amidohydrolase
K6749_06000	COG2188	Transcriptional regulator
K6749_06015	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K6749_06025	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K6749_06035	COG0393	Putative heavy-metal-binding
K6749_06070	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K6749_06075	COG0072	phenylalanine-tRNA ligase activity
K6749_06075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6749_06085	COG0776	regulation of translation
K6749_06095	COG0500	methyltransferase
K6749_06100	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K6749_06105	COG0295	cytidine deaminase activity
K6749_06110	COG1346	cytolysis
K6749_06115	COG1380	Effector of murein hydrolase LrgA
K6749_06120	COG2925	Exonuclease
K6749_06165	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K6749_06190	COG1484	DNA-dependent DNA replication
K6749_06330	COG1823	symporter activity
K6749_06335	COG0702	epimerase
K6749_06340	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K6749_06345	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K6749_06365	COG2988	succinylglutamate desuccinylase activity
K6749_06370	COG4139	cobalamin transport
K6749_06375	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
K6749_06395	COG0583	DNA-binding transcription factor activity
K6749_06405	COG1451	nucleotide metabolic process
K6749_06410	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
K6749_06440	COG3938	Belongs to the proline racemase family
K6749_06455	COG2423	ornithine cyclodeaminase activity
K6749_06460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6749_06465	COG3842	ATPase activity
K6749_06475	COG1177	transmembrane transport
K6749_06485	COG3291	Pkd domain containing protein
K6749_06505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6749_06510	COG0601	transmembrane transport
K6749_06520	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6749_06530	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K6749_06540	COG0625	glutathione transferase activity
K6749_06585	COG3755	Protein conserved in bacteria
K6749_06610	COG1742	UPF0060 membrane protein
K6749_06625	COG1757	Na H antiporter
K6749_06630	COG0174	glutamine synthetase
K6749_06635	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K6749_06640	COG1917	Cupin 2, conserved barrel domain protein
K6749_06640	COG1396	sequence-specific DNA binding
K6749_06645	COG1012	belongs to the aldehyde dehydrogenase family
K6749_06650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6749_06660	COG2957	Belongs to the agmatine deiminase family
K6749_06665	COG1012	belongs to the aldehyde dehydrogenase family
K6749_06670	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K6749_06675	COG2200	EAL domain
K6749_06685	COG1846	Transcriptional regulator
K6749_06690	COG2315	Protein conserved in bacteria
K6749_06730	COG3063	Type IV pilus biogenesis stability protein PilW
K6749_06735	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K6749_06750	COG1560	Kdo2-lipid A biosynthetic process
K6749_06755	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K6749_06760	COG1280	lysine exporter protein (LysE YggA)
K6749_06770	COG1115	amino acid carrier protein
K6749_06795	COG1368	sulfuric ester hydrolase activity
K6749_06800	COG2113	Glycine betaine
K6749_06805	COG4176	ABC-type proline glycine betaine transport system permease component
K6749_06810	COG4175	Glycine betaine
K6749_06825	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6749_06830	COG0456	acetyltransferase
K6749_06835	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K6749_06840	COG0662	Cupin 2, conserved barrel domain protein
K6749_06845	COG0527	aspartate kinase activity
K6749_06850	COG3119	arylsulfatase activity
K6749_06865	COG0641	radical SAM
K6749_06880	COG3119	arylsulfatase activity
K6749_06905	COG1538	Outer membrane efflux protein
K6749_06920	COG1349	DNA-binding transcription factor activity
K6749_06925	COG0673	inositol 2-dehydrogenase activity
K6749_06930	COG4702	Belongs to the UPF0303 family
K6749_06955	COG0471	metal ion transport
K6749_06970	COG3300	MHYT domain
K6749_06970	COG5001	Diguanylate cyclase
K6749_06985	COG1328	CTP reductase activity
K6749_06990	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K6749_07000	COG0861	Integral membrane protein TerC family
K6749_07010	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K6749_07020	COG0814	amino acid
K6749_07035	COG1120	ATPase activity
K6749_07040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6749_07050	COG4774	siderophore transport
K6749_07060	COG1132	(ABC) transporter
K6749_07065	COG1132	(ABC) transporter
K6749_07080	COG0583	DNA-binding transcription factor activity
K6749_07105	COG0443	Heat shock 70 kDa protein
K6749_07110	COG0443	Heat shock 70 kDa protein
K6749_07155	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K6749_07160	COG1643	Atp-dependent helicase
K6749_07175	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6749_07185	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6749_07190	COG1215	transferase activity, transferring glycosyl groups
K6749_07195	COG0438	transferase activity, transferring glycosyl groups
K6749_07225	COG0438	transferase activity, transferring glycosyl groups
K6749_07230	COG0297	glycogen (starch) synthase activity
K6749_07235	COG2204	response regulator
K6749_07265	COG1793	dna ligase
K6749_07275	COG0534	Mate efflux family protein
K6749_07280	COG0307	riboflavin synthase, alpha
K6749_07290	COG3001	Fructosamine kinase
K6749_07300	COG3706	GGDEF domain
K6749_07310	COG0791	NLP P60 protein
K6749_07340	COG3148	PFAM DTW domain containing protein
K6749_07345	COG1940	carbohydrate kinase activity
K6749_07355	COG0303	'Molybdopterin
K6749_07360	COG0746	molybdenum cofactor guanylyltransferase activity
K6749_07365	COG3842	ATPase activity
K6749_07380	COG2204	response regulator
K6749_07385	COG4191	Histidine kinase
K6749_07390	COG0488	(ABC) transporter
K6749_07395	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K6749_07415	COG3381	protein complex oligomerization
K6749_07425	COG0243	molybdopterin cofactor binding
K6749_07425	COG3383	formate dehydrogenase (NAD+) activity
K6749_07430	COG0437	4 iron, 4 sulfur cluster binding
K6749_07455	COG0004	ammonium transporteR
K6749_07465	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K6749_07470	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K6749_07480	COG1177	transmembrane transport
K6749_07490	COG3842	ATPase activity
K6749_07515	COG0589	response to stress
K6749_07520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6749_07535	COG2217	Heavy metal translocating P-type atpase
K6749_07545	COG2010	Cytochrome c
K6749_07560	COG3278	Belongs to the heme-copper respiratory oxidase family
K6749_07575	COG0784	Response regulator, receiver
K6749_07575	COG2205	protein histidine kinase activity
K6749_07650	COG3120	sequence-specific DNA binding
K6749_07655	COG1067	ATP-dependent peptidase activity
K6749_07660	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K6749_07675	COG0488	(ABC) transporter
K6749_07685	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K6749_07685	COG0116	Belongs to the methyltransferase superfamily
K6749_07695	COG0167	dihydroorotate dehydrogenase activity
K6749_07700	COG2902	Dehydrogenase
K6749_07710	COG0308	aminopeptidase N
K6749_07725	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
K6749_07730	COG1956	GAF domain-containing protein
K6749_07735	COG1132	(ABC) transporter
K6749_07740	COG2995	paraquat-inducible protein a
K6749_07745	COG3008	intermembrane lipid transfer
K6749_07770	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K6749_07775	COG1666	GTP binding
K6749_07785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6749_07795	COG4597	amino acid ABC transporter
K6749_07800	COG0765	amino acid transport
K6749_07805	COG1126	abc transporter atp-binding protein
K6749_07810	COG0670	Belongs to the BI1 family
K6749_07820	COG2920	part of a sulfur-relay system
K6749_07825	COG1254	Belongs to the acylphosphatase family
K6749_07850	COG2885	chlorophyll binding
K6749_07875	COG2199	diguanylate cyclase activity
K6749_07875	COG2203	Gaf domain
K6749_07880	COG1414	Transcriptional regulator
K6749_07890	COG0656	L-ascorbic acid biosynthetic process
K6749_07895	COG0583	DNA-binding transcription factor activity
K6749_07905	COG0583	DNA-binding transcription factor activity
K6749_07910	COG2814	Major facilitator Superfamily
K6749_07930	COG1335	isochorismatase
K6749_07935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6749_07950	COG1410	methionine synthase
K6749_07950	COG0646	methionine synthase
K6749_07955	COG1126	abc transporter atp-binding protein
K6749_07960	COG0765	amino acid transport
K6749_07965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6749_07980	COG0583	DNA-binding transcription factor activity
K6749_07995	COG0583	DNA-binding transcription factor activity
K6749_08000	COG0583	DNA-binding transcription factor activity
K6749_08015	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K6749_08020	COG0602	queuosine metabolic process
K6749_08025	COG0561	phosphatase activity
K6749_08050	COG2828	Protein conserved in bacteria
K6749_08060	COG0372	Belongs to the citrate synthase family
K6749_08065	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K6749_08100	COG0730	response to heat
K6749_08105	COG2358	TRAP transporter, solute receptor (TAXI family
K6749_08120	COG0457	Tetratricopeptide repeat
K6749_08190	COG4790	Type iii secretion
K6749_08195	COG4794	Type iii secretion
K6749_08200	COG4791	protein targeting
K6749_08205	COG4792	protein secretion
K6749_08210	COG2207	Transcriptional regulator
K6749_08240	COG3177	Filamentation induced by cAMP protein fic
K6749_08260	COG4669	(LipO)protein
K6749_08330	COG1012	belongs to the aldehyde dehydrogenase family
K6749_08335	COG3284	Transcriptional regulator
K6749_08350	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K6749_08355	COG0363	glucosamine-6-phosphate deaminase activity
K6749_08360	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K6749_08365	COG2207	Transcriptional regulator
K6749_08375	COG4565	transcriptional regulatory protein
K6749_08380	COG3290	protein histidine kinase activity
K6749_08395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6749_08425	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K6749_08435	COG2985	domain, Protein
K6749_08460	COG2272	Belongs to the type-B carboxylesterase lipase family
K6749_08465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6749_08470	COG0729	surface antigen
K6749_08480	COG1280	lysine exporter protein (LysE YggA)
K6749_08485	COG1280	lysine exporter protein (LysE YggA)
K6749_08490	COG5507	3-demethylubiquinone-9 3-methyltransferase
K6749_08515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6749_08520	COG0110	maltose O-acetyltransferase activity
K6749_08790	COG2211	Major facilitator Superfamily
K6749_08815	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K6749_08820	COG1028	Short-chain dehydrogenase reductase Sdr
K6749_08825	COG1169	isochorismate synthase
K6749_08830	COG1021	2,3-dihydroxybenzoate-AMP ligase
K6749_08835	COG1535	isochorismatase
K6749_08835	COG3433	isochorismatase activity
K6749_08840	COG4592	Periplasmic binding protein
K6749_08850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6749_08855	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6749_08860	COG1120	ATPase activity
K6749_08875	COG2382	esterase
K6749_08880	COG4774	siderophore transport
K6749_08880	COG1629	transport
K6749_08990	COG1280	lysine exporter protein (LysE YggA)
K6749_09305	COG0791	NLP P60 protein
K6749_09405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6749_09415	COG3768	UPF0283 membrane protein
K6749_09420	COG3106	COG3106 Predicted ATPase
K6749_09435	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K6749_09440	COG0784	Response regulator, receiver
K6749_09440	COG2205	protein histidine kinase activity
K6749_09450	COG0494	nUDIX hydrolase
K6749_09455	COG0814	amino acid
K6749_09460	COG1760	l-serine dehydratase
K6749_09465	COG2200	EAL domain
K6749_09475	COG0720	synthase
K6749_09480	COG0840	transmembrane signaling receptor activity
K6749_09485	COG0017	Asparaginyl-tRNA synthetase
K6749_09495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6749_09510	COG1448	Aminotransferase
K6749_09530	COG0840	transmembrane signaling receptor activity
K6749_09535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6749_09565	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K6749_09580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6749_09585	COG3108	Peptidase M15
K6749_09590	COG2989	Protein conserved in bacteria
K6749_09615	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6749_09625	COG3088	subunit of a heme lyase
K6749_09625	COG4235	cytochrome complex assembly
K6749_09630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6749_09635	COG1138	Cytochrome C-type biogenesis protein
K6749_09640	COG3301	Polysulphide reductase, NrfD
K6749_09645	COG0437	4 iron, 4 sulfur cluster binding
K6749_09655	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
K6749_09675	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K6749_09680	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K6749_09710	COG0019	diaminopimelate decarboxylase activity
K6749_09750	COG0322	excinuclease ABC activity
K6749_09755	COG2197	response regulator
K6749_09760	COG0417	DNA replication proofreading
K6749_09780	COG1187	pseudouridine synthase activity
K6749_09790	COG0009	L-threonylcarbamoyladenylate synthase
K6749_09795	COG0613	PHP domain protein
K6749_09805	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K6749_09810	COG0512	Glutamine amidotransferase of anthranilate synthase
K6749_09820	COG0134	indole-3-glycerol-phosphate synthase activity
K6749_09820	COG0135	phosphoribosylanthranilate isomerase activity
K6749_09830	COG0159	tryptophan synthase activity
K6749_09835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6749_09840	COG0318	PFAM AMP-dependent synthetase and ligase
K6749_09850	COG1301	dicarboxylic acid transport
K6749_09870	COG2917	probably involved in intracellular septation
K6749_09880	COG2350	Protein conserved in bacteria
K6749_09890	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K6749_09895	COG0583	DNA-binding transcription factor activity
K6749_09910	COG5001	Diguanylate cyclase
K6749_09915	COG1032	radical SAM domain protein
K6749_09940	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K6749_09945	COG0463	Glycosyl transferase, family 2
K6749_09950	COG0745	RESPONSE REGULATOR receiver
K6749_09955	COG3850	Histidine kinase
K6749_09955	COG5002	protein histidine kinase activity
K6749_10010	COG1136	(ABC) transporter
K6749_10010	COG0577	efflux transmembrane transporter activity
K6749_10015	COG0577	efflux transmembrane transporter activity
K6749_10015	COG1136	(ABC) transporter
K6749_10020	COG0577	efflux transmembrane transporter activity
K6749_10020	COG1136	(ABC) transporter
K6749_10030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6749_10055	COG3118	belongs to the thioredoxin family
K6749_10060	COG4232	protein-disulfide reductase activity
K6749_10095	COG2863	cytochrome
K6749_10100	COG3258	Cytochrome c
K6749_10105	COG2995	paraquat-inducible protein a
K6749_10110	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K6749_10110	COG3008	intermembrane lipid transfer
K6749_10130	COG4166	transmembrane transport
K6749_10140	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K6749_10145	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
K6749_10155	COG0539	negative regulation of cytoplasmic translation
K6749_10160	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K6749_10165	COG0616	signal peptide processing
K6749_10170	COG1028	Short-chain dehydrogenase reductase Sdr
K6749_10185	COG0587	DNA-directed DNA polymerase activity
K6749_10190	COG0835	chemotaxis
K6749_10190	COG0784	Response regulator, receiver
K6749_10195	COG1940	carbohydrate kinase activity
K6749_10200	COG0469	pyruvate kinase activity
K6749_10205	COG4667	esterase of the alpha-beta hydrolase superfamily
K6749_10220	COG0733	neurotransmitter:sodium symporter activity
K6749_10235	COG1263	PTS System
K6749_10235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6749_10240	COG0084	hydrolase, TatD family'
K6749_10245	COG0470	DNA polymerase III
K6749_10250	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K6749_10255	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K6749_10285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6749_10290	COG0416	fatty acid biosynthetic process
K6749_10300	COG1399	metal-binding, possibly nucleic acid-binding protein
K6749_10305	COG0424	maF-like protein
K6749_10310	COG0564	pseudouridine synthase activity
K6749_10315	COG1530	ribonuclease E activity
K6749_10320	COG0659	secondary active sulfate transmembrane transporter activity
K6749_10325	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K6749_10330	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
K6749_10340	COG0572	uridine kinase
K6749_10350	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6749_10350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6749_10370	COG2186	Transcriptional regulator
K6749_10375	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K6749_10380	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K6749_10385	COG3318	Belongs to the UPF0149 family
K6749_10385	COG3012	SEC-C Motif Domain Protein
K6749_10390	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6749_10395	COG3706	GGDEF domain
K6749_10400	COG0366	Alpha amylase catalytic
K6749_10405	COG1122	ATPase activity
K6749_10410	COG4120	Belongs to the binding-protein-dependent transport system permease family
K6749_10420	COG3092	negative regulation of chromosome organization
K6749_10425	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K6749_10430	COG0280	phosphate acetyltransferase
K6749_10430	COG0857	belongs to the CobB CobQ family
K6749_10440	COG0435	Glutathione S-transferase
K6749_10450	COG0444	Belongs to the ABC transporter superfamily
K6749_10455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6749_10460	COG0601	transmembrane transport
K6749_10470	COG0314	molybdopterin synthase activity
K6749_10475	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K6749_10480	COG0315	cyclic pyranopterin monophosphate synthase activity
K6749_10485	COG0521	Mo-molybdopterin cofactor biosynthetic process
K6749_10490	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K6749_10495	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K6749_10500	COG2198	Histidine kinase
K6749_10505	COG2204	response regulator
K6749_10510	COG0556	nucleotide-excision repair
K6749_10520	COG1882	Formate acetyltransferase
K6749_10525	COG4657	Part of a membrane complex involved in electron transport
K6749_10530	COG2878	Part of a membrane complex involved in electron transport
K6749_10535	COG4656	Part of a membrane complex involved in electron transport
K6749_10540	COG4658	electron transport chain
K6749_10545	COG4659	FMN binding
K6749_10550	COG4660	Part of a membrane complex involved in electron transport
K6749_10555	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K6749_10560	COG0346	lactoylglutathione lyase activity
K6749_10570	COG2885	chlorophyll binding
K6749_10575	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K6749_10580	COG2056	Na+-H+ antiporter family
K6749_10590	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K6749_10610	COG1454	alcohol dehydrogenase
K6749_10610	COG1012	belongs to the aldehyde dehydrogenase family
K6749_10615	COG2095	MarC family integral membrane protein
K6749_10620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6749_10625	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K6749_10630	COG1757	Na H antiporter
K6749_10645	COG3081	Nucleoid-associated protein
K6749_10650	COG3082	Protein of unknown function (DUF1414)
K6749_10665	COG0123	including yeast histone deacetylase and acetoin utilization protein
K6749_10680	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K6749_10685	COG0778	Nitroreductase
K6749_10695	COG0446	pyridine nucleotide-disulphide oxidoreductase
K6749_10695	COG1902	pentaerythritol trinitrate reductase activity
K6749_10700	COG0616	signal peptide processing
K6749_10705	COG0252	asparaginase activity
K6749_10710	COG3139	Protein of unknown function (DUF1315)
K6749_10720	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6749_10725	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K6749_10740	COG2226	methyltransferase
K6749_10755	COG1785	Belongs to the alkaline phosphatase family
K6749_10765	COG0346	lactoylglutathione lyase activity
K6749_10770	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
K6749_10775	COG0668	transmembrane transport
K6749_10780	COG2983	Belongs to the UPF0260 family
K6749_10785	COG2261	transglycosylase associated protein
K6749_10795	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K6749_10800	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K6749_10815	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K6749_10820	COG2832	Protein of unknown function (DUF454)
K6749_10825	COG0745	RESPONSE REGULATOR receiver
K6749_10830	COG0583	DNA-binding transcription factor activity
K6749_10835	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K6749_10840	COG1286	toxin biosynthetic process
K6749_10845	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
K6749_10850	COG0285	dihydrofolate synthase activity
K6749_10855	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K6749_10860	COG0101	tRNA pseudouridine synthase activity
K6749_10870	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K6749_10875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6749_10880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K6749_10885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6749_10885	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K6749_10890	COG0431	NADPH-dependent FMN reductase
K6749_10900	COG3101	peptidyl-lysine hydroxylation
K6749_10905	COG2860	membrane
K6749_10910	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K6749_10915	COG2890	protein-(glutamine-N5) methyltransferase activity
K6749_10920	COG2840	Smr protein MutS2
K6749_10925	COG2062	phosphohistidine phosphatase, SixA
K6749_10940	COG1250	3-hydroxyacyl-CoA dehydrogenase
K6749_10940	COG1024	Enoyl-CoA hydratase
K6749_10945	COG0183	Belongs to the thiolase family
K6749_10965	COG2067	long-chain fatty acid transport protein
K6749_10975	COG3088	subunit of a heme lyase
K6749_10975	COG4235	cytochrome complex assembly
K6749_10985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6749_10990	COG1138	Cytochrome C-type biogenesis protein
K6749_10995	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K6749_11000	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6749_11005	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6749_11010	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6749_11015	COG4133	protoheme IX ABC transporter activity
K6749_11025	COG0835	chemotaxis
K6749_11035	COG1192	Involved in chromosome partitioning
K6749_11040	COG2201	protein-glutamate methylesterase activity
K6749_11045	COG0643	Histidine kinase
K6749_11045	COG0784	Response regulator, receiver
K6749_11045	COG2198	Histidine kinase
K6749_11050	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
K6749_11090	COG1987	bacterial-type flagellum assembly
K6749_11150	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K6749_11160	COG1677	Flagellar hook-basal body complex protein FliE
K6749_11180	COG1516	flagellar protein fliS
K6749_11190	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K6749_11195	COG1334	flagellar protein FlaG
K6749_11200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6749_11205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6749_11210	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6749_11215	COG2837	iron assimilation
K6749_11240	COG1393	Belongs to the ArsC family
K6749_11245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6749_11260	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
K6749_11265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6749_11275	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K6749_11290	COG4783	chaperone-mediated protein folding
K6749_11295	COG1393	Belongs to the ArsC family
K6749_11315	COG2233	PERMEase
K6749_11320	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K6749_11325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K6749_11330	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K6749_11335	COG0121	glutamine amidotransferase
K6749_11340	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K6749_11345	COG1960	acyl-CoA dehydrogenase activity
K6749_11380	COG0328	RNA-DNA hybrid ribonuclease activity
K6749_11385	COG2226	methyltransferase
K6749_11390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6749_11395	COG0741	lytic transglycosylase activity
K6749_11395	COG1388	LysM domain
K6749_11405	COG3021	interspecies interaction between organisms
K6749_11410	COG0347	Belongs to the P(II) protein family
K6749_11425	COG0825	malonyl-CoA metabolic process
K6749_11430	COG0587	DNA-directed DNA polymerase activity
K6749_11440	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6749_11445	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6749_11455	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6749_11460	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
K6749_11470	COG0750	zinc metalloprotease
K6749_11475	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K6749_11480	COG0575	Belongs to the CDS family
K6749_11485	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K6749_11490	COG0233	cytoplasmic translational termination
K6749_11495	COG0528	UMP kinase activity
K6749_11500	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K6749_11505	COG0052	Belongs to the universal ribosomal protein uS2 family
K6749_11510	COG0024	Methionine aminopeptidase
K6749_11515	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K6749_11525	COG0564	pseudouridine synthase activity
K6749_11560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6749_11565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6749_11590	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K6749_11600	COG0254	rRNA binding
K6749_11605	COG1720	tRNA m6t6A37 methyltransferase activity
K6749_11610	COG0442	prolyl-tRNA aminoacylation
K6749_11630	COG0733	neurotransmitter:sodium symporter activity
K6749_11645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6749_11650	COG0514	ATP-dependent DNA helicase (RecQ)
K6749_11655	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K6749_11660	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K6749_11690	COG0419	ATPase involved in DNA repair
K6749_11755	COG1477	protein flavinylation
K6749_11760	COG2871	sodium ion transport
K6749_11765	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6749_11770	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6749_11775	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6749_11780	COG1805	sodium ion transport
K6749_11785	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6749_11790	COG0271	Belongs to the BolA IbaG family
K6749_11795	COG2813	Specifically methylates the guanine in position
K6749_11800	COG3056	Lipoprotein
K6749_11820	COG1595	DNA-templated transcription, initiation
K6749_11840	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K6749_11845	COG0693	protein deglycase activity
K6749_11850	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K6749_11855	COG3706	GGDEF domain
K6749_11860	COG2166	iron-sulfur cluster assembly
K6749_11865	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K6749_11870	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
K6749_11880	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K6749_11880	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K6749_11890	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K6749_11895	COG1074	ATP-dependent DNA helicase activity
K6749_11900	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K6749_11920	COG3141	response to X-ray
K6749_11935	COG2171	N-acyltransferase activity
K6749_11940	COG0584	glycerophosphoryl diester phosphodiesterase
K6749_11945	COG2271	Major facilitator Superfamily
K6749_11950	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K6749_11955	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K6749_11960	COG1349	DNA-binding transcription factor activity
K6749_11965	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K6749_11970	COG0598	Magnesium transport protein CorA
K6749_11990	COG1609	Transcriptional regulator
K6749_11995	COG0583	DNA-binding transcription factor activity
K6749_12035	COG1022	Amp-dependent synthetase and ligase
K6749_12045	COG0583	DNA-binding transcription factor activity
K6749_12050	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K6749_12055	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K6749_12065	COG0560	Phosphoserine phosphatase
K6749_12075	COG0813	purine-nucleoside phosphorylase activity
K6749_12080	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K6749_12085	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K6749_12090	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K6749_12095	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6749_12100	COG0084	hydrolase, TatD family'
K6749_12130	COG3153	acetyltransferase
K6749_12135	COG3154	lipid carrier protein
K6749_12150	COG0826	peptidase U32
K6749_12155	COG0826	peptidase U32
K6749_12160	COG0534	Mate efflux family protein
K6749_12175	COG1185	polyribonucleotide nucleotidyltransferase activity
K6749_12180	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K6749_12185	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K6749_12190	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K6749_12195	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K6749_12200	COG0195	Participates in both transcription termination and antitermination
K6749_12205	COG0779	Required for maturation of 30S ribosomal subunits
K6749_12220	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K6749_12225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6749_12230	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K6749_12235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K6749_12240	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K6749_12245	COG1534	Rna-binding protein
K6749_12250	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6749_12255	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6749_12260	COG2027	D-alanyl-D-alanine carboxypeptidase
K6749_12270	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K6749_12275	COG0739	heme binding
K6749_12300	COG0628	permease
K6749_12310	COG2205	protein histidine kinase activity
K6749_12310	COG0784	Response regulator, receiver
K6749_12315	COG0747	negative chemotaxis
K6749_12325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6749_12330	COG0444	Belongs to the ABC transporter superfamily
K6749_12335	COG4608	Belongs to the ABC transporter superfamily
K6749_12345	COG2971	BadF BadG BcrA BcrD
K6749_12360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6749_12365	COG3842	ATPase activity
K6749_12375	COG1840	ABC-type Fe3 transport system, periplasmic component
K6749_12380	COG0004	ammonium transporteR
K6749_12390	COG3112	Uncharacterised protein family (UPF0231)
K6749_12395	COG1049	propionate catabolic process, 2-methylcitrate cycle
K6749_12400	COG1752	Esterase of the alpha-beta hydrolase superfamily
K6749_12405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6749_12410	COG1643	Atp-dependent helicase
K6749_12415	COG1489	DNA binding
K6749_12425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K6749_12435	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K6749_12440	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K6749_12445	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K6749_12450	COG1560	Kdo2-lipid A biosynthetic process
K6749_12455	COG0842	Transport permease protein
K6749_12460	COG1131	(ABC) transporter
K6749_12465	COG0659	secondary active sulfate transmembrane transporter activity
K6749_12470	COG0288	reversible hydration of carbon dioxide
K6749_12485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6749_12490	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6749_12495	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K6749_12500	COG2186	Transcriptional regulator
K6749_12510	COG0157	Belongs to the NadC ModD family
K6749_12520	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K6749_12525	COG1459	type II secretion system
K6749_12535	COG0237	dephospho-CoA kinase activity
K6749_12540	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
K6749_12545	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K6749_12560	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K6749_12565	COG0228	four-way junction DNA binding
K6749_12570	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K6749_12575	COG4137	Cytochrome C assembly protein
K6749_12580	COG4536	flavin adenine dinucleotide binding
K6749_12585	COG1854	S-ribosylhomocysteine lyase activity
K6749_12595	COG2918	glutathione biosynthetic process
K6749_12600	COG0612	Peptidase, M16
K6749_12605	COG1238	metal cluster binding
K6749_12615	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K6749_12620	COG5016	pyruvate
K6749_12620	COG0511	ligase activity, forming carbon-carbon bonds
K6749_12625	COG3630	sodium ion export across plasma membrane
K6749_12685	COG0527	aspartate kinase activity
K6749_12690	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K6749_12695	COG2137	regulation of response to DNA damage stimulus
K6749_12700	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K6749_12705	COG1546	Belongs to the CinA family
K6749_12710	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K6749_12715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K6749_12725	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K6749_12730	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K6749_12740	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K6749_12745	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K6749_12750	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K6749_12755	COG0148	phosphopyruvate hydratase activity
K6749_12760	COG0504	CTP synthase activity
K6749_12765	COG3956	TIGRFAM MazG family protein
K6749_12770	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K6749_12775	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K6749_12785	COG0736	holo-[acyl-carrier-protein] synthase activity
K6749_12790	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K6749_12795	COG1381	Involved in DNA repair and RecF pathway recombination
K6749_12800	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K6749_12810	COG0681	Belongs to the peptidase S26 family
K6749_12815	COG0481	GTPase activity
K6749_12820	COG3086	response to oxidative stress
K6749_12835	COG1595	DNA-templated transcription, initiation
K6749_12840	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K6749_12850	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K6749_12870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6749_12875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6749_12880	COG3079	Belongs to the UPF0149 family
K6749_12885	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K6749_12895	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K6749_12900	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K6749_12905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6749_12915	COG0583	DNA-binding transcription factor activity
K6749_12930	COG0668	transmembrane transport
K6749_12935	COG0191	fructose-bisphosphate aldolase activity
K6749_12950	COG4771	TonB-dependent receptor
K6749_12955	COG0583	DNA-binding transcription factor activity
K6749_12960	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K6749_12965	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K6749_12975	COG3091	SprT-like family
K6749_12980	COG2356	endonuclease I
K6749_12985	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K6749_12990	COG0189	ligase activity
K6749_12995	COG1678	Uncharacterized ACR, COG1678
K6749_13000	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K6749_13015	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K6749_13020	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K6749_13025	COG0762	integral membrane protein
K6749_13030	COG1872	DUF167
K6749_13040	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K6749_13045	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K6749_13050	COG2066	Belongs to the glutaminase family
K6749_13060	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K6749_13070	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
K6749_13190	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K6749_13195	COG1609	Transcriptional regulator
K6749_13200	COG3394	polysaccharide catabolic process
K6749_13205	COG1486	melibiose metabolic process
K6749_13210	COG1447	Phosphotransferase system cellobiose-specific component IIA
K6749_13215	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K6749_13220	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K6749_13225	COG0726	polysaccharide deacetylase
K6749_13235	COG1028	Short-chain dehydrogenase reductase Sdr
K6749_13250	COG0795	lipopolysaccharide-transporting ATPase activity
K6749_13255	COG0795	lipopolysaccharide-transporting ATPase activity
K6749_13260	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K6749_13265	COG2927	DNA polymerase III (CHI subunit)
K6749_13270	COG0525	valine-tRNA ligase activity
K6749_13280	COG0456	acetyltransferase
K6749_13310	COG0540	Belongs to the ATCase OTCase family
K6749_13315	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K6749_13320	COG0251	oxidation-reduction process
K6749_13325	COG0204	Acyl-transferase
K6749_13330	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K6749_13335	COG5007	Belongs to the BolA IbaG family
K6749_13345	COG2854	intermembrane phospholipid transfer
K6749_13350	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K6749_13355	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K6749_13360	COG1127	ABC transporter
K6749_13370	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K6749_13370	COG0517	IMP dehydrogenase activity
K6749_13380	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K6749_13385	COG1137	ATPase activity
K6749_13395	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K6749_13400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6749_13405	COG1660	Displays ATPase and GTPase activities
K6749_13410	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6749_13415	COG2239	Acts as a magnesium transporter
K6749_13420	COG0312	modulator of DNA gyrase
K6749_13425	COG3028	Belongs to the UPF0307 family
K6749_13430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6749_13435	COG0564	pseudouridine synthase activity
K6749_13445	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K6749_13450	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K6749_13455	COG0312	modulator of DNA gyrase
K6749_13460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6749_13465	COG3164	Protein of unknown function
K6749_13475	COG0424	maF-like protein
K6749_13480	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K6749_13485	COG1792	Involved in formation and maintenance of cell shape
K6749_13490	COG1077	Cell shape determining protein MreB Mrl
K6749_13525	COG2165	general secretion pathway protein
K6749_13535	COG1459	type II secretion system
K6749_13540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K6749_13550	COG3409	Peptidoglycan-binding domain 1 protein
K6749_13550	COG3267	Type II secretory pathway component ExeA
K6749_13555	COG1450	Type ii and iii secretion system protein
K6749_13575	COG2200	EAL domain
K6749_13575	COG2199	diguanylate cyclase activity
K6749_13580	COG0629	single-stranded DNA binding
K6749_13595	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K6749_13605	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K6749_13610	COG0527	aspartate kinase activity
K6749_13615	COG1410	methionine synthase
K6749_13615	COG0646	methionine synthase
K6749_13675	COG0175	sulfate reduction
K6749_13680	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6749_13685	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K6749_13705	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6749_13710	COG0735	belongs to the Fur family
K6749_13720	COG0166	Belongs to the GPI family
K6749_13725	COG0432	Pfam Uncharacterised protein family UPF0047
K6749_13730	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K6749_13755	COG2965	DNA replication, synthesis of RNA primer
K6749_13760	COG0360	Binds together with S18 to 16S ribosomal RNA
K6749_13765	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K6749_13770	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K6749_13780	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K6749_13785	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K6749_13815	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K6749_13825	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K6749_13825	COG0678	peroxiredoxin activity
K6749_13830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6749_13840	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K6749_13840	COG0165	Argininosuccinate lyase
K6749_13845	COG0137	argininosuccinate synthase activity
K6749_13855	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K6749_13865	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K6749_13875	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K6749_13880	COG0527	aspartate kinase activity
K6749_13880	COG0460	homoserine dehydrogenase
K6749_13885	COG0626	cystathionine gamma-synthase activity
K6749_13890	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
K6749_13895	COG0281	malic enzyme
K6749_13910	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K6749_13915	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K6749_13935	COG2923	Belongs to the DsrF TusC family
K6749_13940	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
K6749_13945	COG2964	Protein conserved in bacteria
K6749_13950	COG0545	Peptidyl-prolyl cis-trans isomerase
K6749_13965	COG1446	asparaginase
K6749_13970	COG1047	Peptidyl-prolyl cis-trans
K6749_13985	COG2249	NAD(P)H dehydrogenase (quinone) activity
K6749_13990	COG0488	(ABC) transporter
K6749_14000	COG0429	hydrolase of the alpha beta-hydrolase fold
K6749_14010	COG3954	Phosphoribulokinase
K6749_14015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6749_14035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K6749_14040	COG0512	Glutamine amidotransferase of anthranilate synthase
K6749_14055	COG0180	Tryptophanyl-tRNA synthetase
K6749_14060	COG0546	phosphoglycolate phosphatase activity
K6749_14065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6749_14070	COG0557	exoribonuclease II activity
K6749_14075	COG1959	2 iron, 2 sulfur cluster binding
K6749_14080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K6749_14080	COG1017	nitric oxide dioxygenase activity
K6749_14085	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
K6749_14090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K6749_14095	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
K6749_14100	COG0330	HflC and HflK could
K6749_14105	COG0330	HflC and HflK could
K6749_14110	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K6749_14120	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K6749_14125	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K6749_14135	COG0802	atpase or kinase
K6749_14140	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K6749_14205	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K6749_14210	COG1162	GTPase activity
K6749_14215	COG0688	phosphatidylethanolamine metabolic process
K6749_14220	COG0471	metal ion transport
K6749_14230	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K6749_14235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6749_14240	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K6749_14245	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K6749_14250	COG1045	serine acetyltransferase
K6749_14255	COG4942	peptidase
K6749_14275	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K6749_14280	COG1053	succinate dehydrogenase
K6749_14285	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K6749_14290	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K6749_14295	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K6749_14310	COG1509	lysine 2,3-aminomutase activity
K6749_14315	COG1285	pathogenesis
K6749_14325	COG0459	protein refolding
K6749_14335	COG0534	Mate efflux family protein
K6749_14340	COG0205	6-phosphofructokinase activity
K6749_14350	COG3678	ATP-independent chaperone mediated protein folding
K6749_14355	COG0745	RESPONSE REGULATOR receiver
K6749_14360	COG2205	protein histidine kinase activity
K6749_14370	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K6749_14375	COG3030	protein affecting phage T7 exclusion by the F plasmid
K6749_14380	COG1027	Aspartate ammonia-lyase
K6749_14385	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K6749_14390	COG4232	protein-disulfide reductase activity
K6749_14400	COG3263	regulation of cellular component size
K6749_14410	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6749_14435	COG2814	Major facilitator Superfamily
K6749_14450	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6749_14455	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K6749_14460	COG0511	ligase activity, forming carbon-carbon bonds
K6749_14465	COG0439	Biotin carboxylase
K6749_14470	COG2264	protein methyltransferase activity
K6749_14475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6749_14480	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K6749_14490	COG0488	(ABC) transporter
K6749_14550	COG1982	Orn Lys Arg decarboxylase major
K6749_14555	COG0531	amino acid
K6749_14560	COG3710	Transcriptional regulator
K6749_14565	COG0789	Transcriptional regulator
K6749_14575	COG0151	Belongs to the GarS family
K6749_14590	COG1253	flavin adenine dinucleotide binding
K6749_14595	COG3068	Protein conserved in bacteria
K6749_14605	COG1573	uracil-dna glycosylase
K6749_14610	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K6749_14615	COG2816	NAD+ diphosphatase activity
K6749_14620	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
K6749_14625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K6749_14630	COG0085	RNA polymerase activity
K6749_14635	COG0222	ribosome binding
K6749_14640	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K6749_14655	COG0250	Participates in transcription elongation, termination and antitermination
K6749_14660	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K6749_14665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K6749_14695	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K6749_14695	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K6749_14700	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K6749_14710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6749_14775	COG4206	TonB-dependent receptor
K6749_14795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6749_14800	COG0534	Mate efflux family protein
K6749_14805	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K6749_14810	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K6749_14815	COG2937	Belongs to the GPAT DAPAT family
K6749_14820	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K6749_14825	COG3161	chorismate lyase activity
K6749_14830	COG1580	Controls the rotational direction of flagella during chemotaxis
K6749_14835	COG0705	Rhomboid family
K6749_14840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6749_14850	COG2177	Part of the ABC transporter FtsEX involved in
K6749_14855	COG2884	Cell division ATP-binding protein ftsE
K6749_14860	COG0552	protein localization to endoplasmic reticulum
K6749_14865	COG0742	ribosomal rna small subunit methyltransferase
K6749_14875	COG2095	MarC family integral membrane protein
K6749_14915	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K6749_14920	COG0640	Transcriptional regulator
K6749_14925	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K6749_14930	COG1280	lysine exporter protein (LysE YggA)
K6749_14935	COG2267	carboxylic ester hydrolase activity
K6749_14940	COG0561	phosphatase activity
K6749_14955	COG3148	PFAM DTW domain containing protein
K6749_14960	COG2200	EAL domain
K6749_14960	COG3287	FIST C domain
K6749_14960	COG2199	diguanylate cyclase activity
K6749_14965	COG1011	Hydrolase
K6749_14970	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K6749_14985	COG0019	diaminopimelate decarboxylase activity
K6749_14995	COG1965	Belongs to the frataxin family
K6749_15000	COG3072	Adenylate cyclase
K6749_15005	COG0181	hydroxymethylbilane synthase activity
K6749_15010	COG1587	Uroporphyrinogen-III synthase
K6749_15015	COG2959	enzyme of heme biosynthesis
K6749_15020	COG3071	HemY protein
K6749_15060	COG0633	Ferredoxin
K6749_15065	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K6749_15080	COG3118	belongs to the thioredoxin family
K6749_15085	COG0513	Belongs to the DEAD box helicase family
K6749_15090	COG0248	Ppx GppA phosphatase
K6749_15100	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K6749_15110	COG0514	ATP-dependent DNA helicase (RecQ)
K6749_15115	COG2962	Rard protein
K6749_15125	COG1280	lysine exporter protein (LysE YggA)
K6749_15130	COG0405	Gamma-glutamyltransferase
K6749_15135	COG0210	DNA helicase
K6749_15145	COG3220	belongs to the UPF0276 family
K6749_15175	COG0006	proline dipeptidase activity
K6749_15175	COG0006	proline dipeptidase activity
K6749_15190	COG2104	thiamine diphosphate biosynthetic process
K6749_15195	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K6749_15215	COG2132	Multicopper oxidase
K6749_15260	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K6749_15275	COG0408	coproporphyrinogen oxidase activity
K6749_15280	COG0009	L-threonylcarbamoyladenylate synthase
K6749_15285	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K6749_15290	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K6749_15295	COG0551	DNA topoisomerase type I activity
K6749_15300	COG2922	Belongs to the Smg family
K6749_15305	COG0758	DNA mediated transformation
K6749_15315	COG0242	peptide deformylase activity
K6749_15320	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K6749_15325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K6749_15325	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K6749_15330	COG0569	domain protein
K6749_15335	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6749_15345	COG1272	protein, Hemolysin III
K6749_15350	COG4326	sporulation control protein
K6749_15360	COG3084	Protein conserved in bacteria
K6749_15370	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K6749_15375	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K6749_15380	COG0204	Acyl-transferase
K6749_15390	COG0606	chelatase, subunit chli
K6749_15400	COG3978	acetolactate synthase activity
K6749_15405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6749_15410	COG0129	dihydroxy-acid dehydratase activity
K6749_15420	COG0583	DNA-binding transcription factor activity
K6749_15425	COG2814	Major facilitator Superfamily
K6749_15430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6749_15435	COG0765	amino acid transport
K6749_15445	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K6749_15450	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K6749_15455	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K6749_15460	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K6749_15465	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K6749_15470	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K6749_15480	COG0356	it plays a direct role in the translocation of protons across the membrane
K6749_15485	COG3312	ion transport
K6749_15490	COG1475	DNA binding
K6749_15495	COG1192	Involved in chromosome partitioning
K6749_15500	COG0357	Ribosomal RNA small subunit methyltransferase G
K6749_15505	COG0445	tRNA wobble uridine modification
K6749_15510	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K6749_15520	COG0706	membrane insertase activity
K6749_15530	COG0594	ribonuclease P activity
K6749_15540	COG1126	abc transporter atp-binding protein
K6749_15555	COG1882	Formate acetyltransferase
K6749_15585	COG1360	Flagellar Motor Protein
K6749_15590	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K6749_15595	COG1191	sigma factor activity
K6749_15600	COG1580	Controls the rotational direction of flagella during chemotaxis
K6749_15615	COG1516	flagellar protein fliS
K6749_15620	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K6749_15625	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6749_15640	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K6749_15650	COG1987	bacterial-type flagellum assembly
K6749_15690	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K6749_15750	COG0346	lactoylglutathione lyase activity
K6749_15775	COG0745	RESPONSE REGULATOR receiver
K6749_15800	COG5001	Diguanylate cyclase
K6749_15800	COG3300	MHYT domain
K6749_15805	COG0156	8-amino-7-oxononanoate synthase activity
K6749_15810	COG1063	alcohol dehydrogenase
K6749_15845	COG0668	transmembrane transport
K6749_15855	COG1304	FMN binding
K6749_15860	COG1620	l-lactate permease
K6749_15865	COG0583	DNA-binding transcription factor activity
K6749_15870	COG1505	serine-type exopeptidase activity
K6749_15875	COG4172	Belongs to the ABC transporter superfamily
K6749_15885	COG1067	ATP-dependent peptidase activity
K6749_15895	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6749_15915	COG1247	-acetyltransferase
K6749_15920	COG0437	4 iron, 4 sulfur cluster binding
K6749_15925	COG0348	domain, Protein
K6749_15945	COG1122	ATPase activity
K6749_15950	COG4720	Psort location CytoplasmicMembrane, score
K6749_15955	COG1566	PFAM secretion protein HlyD family protein
K6749_15980	COG0813	purine-nucleoside phosphorylase activity
K6749_15985	COG3272	Protein of unknown function (DUF1722)
K6749_15990	COG0789	Transcriptional regulator
K6749_15995	COG0415	Belongs to the DNA photolyase family
K6749_16000	COG1376	ErfK ybiS ycfS ynhG family protein
K6749_16000	COG1388	LysM domain
K6749_16010	COG0513	Belongs to the DEAD box helicase family
K6749_16015	COG1770	oligopeptidase
K6749_16020	COG4771	TonB-dependent receptor
K6749_16050	COG0573	inorganic phosphate transmembrane transporter activity
K6749_16055	COG0581	inorganic phosphate transmembrane transporter activity
K6749_16060	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K6749_16075	COG2304	oxidoreductase activity
K6749_16095	COG0714	Associated with various cellular activities
K6749_16110	COG2197	response regulator
K6749_16145	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K6749_16150	COG1120	ATPase activity
K6749_16155	COG4774	siderophore transport
K6749_16160	COG1132	(ABC) transporter
K6749_16165	COG2205	protein histidine kinase activity
K6749_16165	COG2205	protein histidine kinase activity
K6749_16170	COG0745	RESPONSE REGULATOR receiver
K6749_16175	COG0569	domain protein
K6749_16180	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6749_16185	COG0583	DNA-binding transcription factor activity
K6749_16190	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6749_16200	COG1012	belongs to the aldehyde dehydrogenase family
K6749_16205	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6749_16210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6749_16220	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
K6749_16225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6749_16255	COG2084	Dehydrogenase
K6749_16260	COG0753	catalase activity
K6749_16270	COG2130	NADP-dependent
K6749_16275	COG1309	transcriptional regulator
K6749_16280	COG3097	Belongs to the UPF0267 family
K6749_16320	COG0489	protein tyrosine kinase activity
K6749_16320	COG3206	protein involved in exopolysaccharide biosynthesis
K6749_16335	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6749_16340	COG3842	ATPase activity
K6749_16350	COG1175	transmembrane transport
K6749_16355	COG3833	ABC-type maltose transport systems, permease component
K6749_16385	COG2375	cellular response to nickel ion
K6749_16385	COG1132	(ABC) transporter
K6749_16390	COG4774	siderophore transport
K6749_16395	COG4607	ABC-type enterochelin transport system periplasmic component
K6749_16400	COG4605	iron ion homeostasis
K6749_16405	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6749_16415	COG2354	Protein conserved in bacteria
K6749_16420	COG0418	dihydroorotase activity
K6749_16425	COG0401	homolog of Blt101
K6749_16430	COG0633	Ferredoxin
K6749_16430	COG3217	Mosc domain protein beta barrel domain protein
K6749_16430	COG0633	Ferredoxin
K6749_16430	COG3217	Mosc domain protein beta barrel domain protein
K6749_16440	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K6749_16480	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K6749_16485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6749_16495	COG0848	biopolymer transport protein
K6749_16500	COG0811	peptide transport
K6749_16505	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K6749_16515	COG3721	Heme iron utilization protein
K6749_16520	COG0748	coenzyme F420 binding
K6749_16530	COG0784	Response regulator, receiver
K6749_16530	COG0835	chemotaxis
K6749_16535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6749_16540	COG0534	Mate efflux family protein
K6749_16545	COG0444	Belongs to the ABC transporter superfamily
K6749_16550	COG4608	Belongs to the ABC transporter superfamily
K6749_16555	COG0747	negative chemotaxis
K6749_16565	COG1349	DNA-binding transcription factor activity
K6749_16570	COG2084	Dehydrogenase
K6749_16575	COG3395	kinase activity
K6749_16580	COG0235	Class ii aldolase
K6749_16585	COG3622	Belongs to the hyi family
K6749_16590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6749_16595	COG2610	gluconate transmembrane transporter activity
K6749_16615	COG0583	DNA-binding transcription factor activity
K6749_16620	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K6749_16630	COG4934	collagen metabolic process
K6749_16640	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K6749_16645	COG0789	Transcriptional regulator
K6749_16650	COG0366	Alpha amylase catalytic
K6749_16670	COG2249	NAD(P)H dehydrogenase (quinone) activity
K6749_16675	COG0589	response to stress
K6749_16680	COG0488	(ABC) transporter
K6749_16685	COG1505	serine-type exopeptidase activity
K6749_16695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6749_16705	COG2067	long-chain fatty acid transport protein
K6749_16715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6749_16740	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6749_16760	COG3383	formate dehydrogenase (NAD+) activity
K6749_16770	COG0842	Transport permease protein
K6749_16775	COG1131	(ABC) transporter
K6749_16790	COG1881	PFAM PEBP family protein
K6749_16800	COG0798	PFAM Bile acid sodium symporter
K6749_16815	COG1733	regulation of RNA biosynthetic process
K6749_16840	COG4989	oxidoreductase activity
K6749_16865	COG0814	amino acid
K6749_16880	COG3314	Sporulation integral membrane protein YlbJ
K6749_16900	COG0739	heme binding
K6749_16905	COG5001	Diguanylate cyclase
K6749_16910	COG0583	DNA-binding transcription factor activity
K6749_16915	COG2814	Major facilitator Superfamily
K6749_16930	COG0697	spore germination
K6749_16935	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6749_16945	COG0179	Fumarylacetoacetate (FAA) hydrolase
K6749_16965	COG1280	lysine exporter protein (LysE YggA)
K6749_16975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6749_16980	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K6749_16985	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K6749_16990	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K6749_16995	COG1845	cytochrome c oxidase, subunit III
K6749_17015	COG1612	heme a metabolic process
K6749_17020	COG0109	protoheme IX farnesyltransferase activity
K6749_17025	COG0545	Peptidyl-prolyl cis-trans isomerase
K6749_17055	COG1278	Cold shock
K6749_17060	COG3036	rescue of stalled ribosome
K6749_17065	COG2199	diguanylate cyclase activity
K6749_17080	COG1132	(ABC) transporter
K6749_17090	COG1538	Outer membrane efflux protein
K6749_17095	COG2205	protein histidine kinase activity
K6749_17095	COG0784	Response regulator, receiver
K6749_17120	COG0840	transmembrane signaling receptor activity
K6749_17125	COG0783	Belongs to the Dps family
K6749_17135	COG2133	pyrroloquinoline quinone binding
K6749_17140	COG1454	alcohol dehydrogenase
K6749_17145	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
K6749_17170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K6749_17175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6749_17180	COG3186	Phenylalanine-4-hydroxylase
K6749_17205	COG3530	Putative quorum-sensing-regulated virulence factor
K6749_17225	COG0513	Belongs to the DEAD box helicase family
K6749_17230	COG4628	conserved protein (DUF2132)
K6749_17240	COG0133	tryptophan synthase activity
K6749_17250	COG1278	Cold shock
K6749_17260	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
K6749_17275	COG0513	Belongs to the DEAD box helicase family
K6749_17295	COG2200	EAL domain
K6749_17300	COG1119	ATPase activity
K6749_17335	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
K6749_17340	COG0513	Belongs to the DEAD box helicase family
K6749_17350	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K6749_17360	COG1073	alpha beta
K6749_17365	COG1073	alpha beta
K6749_17380	COG0730	response to heat
K6749_17395	COG0735	belongs to the Fur family
K6749_17400	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K6749_17410	COG0523	cobalamin synthesis protein
K6749_17415	COG2988	succinylglutamate desuccinylase activity
K6749_17420	COG0739	heme binding
K6749_17425	COG0523	cobalamin synthesis protein
K6749_17440	COG2095	MarC family integral membrane protein
K6749_17470	COG1024	Enoyl-CoA hydratase
K6749_17475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K6749_17480	COG1960	acyl-CoA dehydrogenase activity
K6749_17490	COG0183	Belongs to the thiolase family
K6749_17505	COG1024	Enoyl-CoA hydratase
K6749_17510	COG1024	Enoyl-CoA hydratase
K6749_17520	COG1028	Short-chain dehydrogenase reductase Sdr
K6749_17525	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K6749_17530	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K6749_17535	COG1845	cytochrome c oxidase, subunit III
K6749_17540	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K6749_17545	COG0109	protoheme IX farnesyltransferase activity
K6749_17550	COG0446	pyridine nucleotide-disulphide oxidoreductase
K6749_17550	COG1902	pentaerythritol trinitrate reductase activity
K6749_17565	COG1012	belongs to the aldehyde dehydrogenase family
K6749_17575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6749_17605	COG1126	abc transporter atp-binding protein
K6749_17610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6749_17615	COG4215	(ABC) transporter
K6749_17620	COG4160	amino acid transport
K6749_17690	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6749_17695	COG2176	DNA-directed DNA polymerase activity
K6749_17700	COG0517	IMP dehydrogenase activity
K6749_17705	COG2186	Transcriptional regulator
K6749_17710	COG2186	Transcriptional regulator
K6749_17755	COG1917	Cupin 2, conserved barrel domain protein
K6749_17760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6749_17765	COG0800	Aldolase
K6749_17775	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K6749_17780	COG1028	Short-chain dehydrogenase reductase Sdr
K6749_17785	COG2847	Copper chaperone PCu(A)C
K6749_17845	COG0814	amino acid
K6749_17855	COG0243	molybdopterin cofactor binding
K6749_17875	COG3707	response regulator
K6749_17880	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K6749_17880	COG1116	anion transmembrane transporter activity
K6749_17885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6749_17890	COG1116	anion transmembrane transporter activity
K6749_17895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6749_17895	COG2146	nitrite reductase [NAD(P)H] activity
K6749_17925	COG0745	RESPONSE REGULATOR receiver
K6749_17945	COG0515	serine threonine protein kinase
K6749_17945	COG2815	serine threonine protein kinase
K6749_17980	COG0631	protein serine/threonine phosphatase activity
K6749_18050	COG0420	3'-5' exonuclease activity
K6749_18055	COG0419	ATPase involved in DNA repair
K6749_18065	COG3040	lipid binding
K6749_18075	COG1288	antiporter activity
K6749_18085	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
K6749_18100	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K6749_18115	COG0583	DNA-binding transcription factor activity
K6749_18120	COG0277	FAD linked oxidase domain protein
K6749_18135	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K6749_18185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K6749_18205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6749_18210	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6749_18220	COG2116	formate transmembrane transporter activity
K6749_18240	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K6749_18275	COG3118	belongs to the thioredoxin family
K6749_18280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6749_18305	COG2271	Major facilitator Superfamily
K6749_18310	COG3851	Histidine kinase
K6749_18315	COG2197	response regulator
K6749_18325	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K6749_18330	COG0583	DNA-binding transcription factor activity
K6749_18335	COG0243	molybdopterin cofactor binding
K6749_18350	COG0384	phenazine biosynthesis protein PhzF
K6749_18355	COG1794	racemase activity, acting on amino acids and derivatives
K6749_18385	COG1328	CTP reductase activity
K6749_18390	COG0602	queuosine metabolic process
K6749_18395	COG0534	Mate efflux family protein
K6749_18400	COG2207	Transcriptional regulator
K6749_18410	COG4067	protein conserved in archaea
K6749_18410	COG0189	ligase activity
K6749_18420	COG3111	PFAM Bacterial OB fold (BOF) protein
K6749_18430	COG0725	ABC transporter, periplasmic molybdate-binding protein
K6749_18435	COG4149	molybdate abc transporter
K6749_18440	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K6749_18450	COG4251	negative regulation of phosphorylation
K6749_18450	COG5001	Diguanylate cyclase
K6749_18450	COG3706	GGDEF domain
K6749_18450	COG2203	Gaf domain
K6749_18470	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K6749_18475	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K6749_18500	COG3140	Belongs to the UPF0181 family
K6749_18515	COG0583	DNA-binding transcription factor activity
K6749_18675	COG0023	Translation Initiation Factor
K6749_18685	COG1181	Belongs to the D-alanine--D-alanine ligase family
K6749_18695	COG1042	CoA-binding domain protein
K6749_18695	COG0045	succinate-CoA ligase (ADP-forming) activity
K6749_18695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6749_18700	COG0583	DNA-binding transcription factor activity
K6749_18715	COG3447	MASE1 domain protein
K6749_18715	COG5001	Diguanylate cyclase
K6749_18715	COG5002	protein histidine kinase activity
K6749_18720	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K6749_18725	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K6749_18730	COG1984	allophanate hydrolase subunit 2
K6749_18740	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K6749_18745	COG4181	ATPase activity
K6749_18755	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K6749_18760	COG5001	Diguanylate cyclase
K6749_18760	COG3300	MHYT domain
K6749_18795	COG4533	DNA binding
K6749_18805	COG2050	protein possibly involved in aromatic compounds catabolism
K6749_18820	COG2067	long-chain fatty acid transport protein
K6749_18825	COG2267	carboxylic ester hydrolase activity
K6749_18845	COG0861	Integral membrane protein TerC family
K6749_18850	COG0737	Belongs to the 5'-nucleotidase family
K6749_18855	COG3593	DNA synthesis involved in DNA repair
K6749_18865	COG0583	DNA-binding transcription factor activity
K6749_18870	COG2116	formate transmembrane transporter activity
K6749_18875	COG2353	YceI-like domain
K6749_18880	COG3038	cytochrome b561
K6749_18900	COG0513	Belongs to the DEAD box helicase family
K6749_18915	COG0840	transmembrane signaling receptor activity
K6749_18935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6749_18940	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K6749_18945	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K6749_18955	COG2207	Transcriptional regulator
K6749_18960	COG1979	alcohol dehydrogenase
K6749_18970	COG1126	abc transporter atp-binding protein
K6749_18975	COG0765	amino acid transport
K6749_18980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6749_18985	COG0765	amino acid transport
K6749_18990	COG2199	diguanylate cyclase activity
K6749_18990	COG2200	EAL domain
K6749_18990	COG2203	Gaf domain
K6749_19005	COG1609	Transcriptional regulator
K6749_19010	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6749_19010	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6749_19015	COG1105	Belongs to the carbohydrate kinase PfkB family
K6749_19020	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K6749_19020	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
K6749_19020	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K6749_19050	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K6749_19060	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K6749_19065	COG0509	glycine decarboxylation via glycine cleavage system
K6749_19075	COG0346	lactoylglutathione lyase activity
K6749_19080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6749_19085	COG0583	DNA-binding transcription factor activity
K6749_19090	COG0697	spore germination
K6749_19095	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K6749_19150	COG2176	DNA-directed DNA polymerase activity
K6749_19190	COG0242	peptide deformylase activity
K6749_19220	COG2239	Acts as a magnesium transporter
K6749_19240	COG0346	lactoylglutathione lyase activity
K6749_19245	COG1902	pentaerythritol trinitrate reductase activity
K6749_19255	COG2755	lipolytic protein G-D-S-L family
K6749_19255	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K6749_19265	COG5642	Protein of unknown function (DUF2384)
K6749_19270	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K6749_19305	COG2076	Multidrug Resistance protein
K6749_19325	COG2962	Rard protein
K6749_19340	COG0784	Response regulator, receiver
K6749_19340	COG0835	chemotaxis
K6749_19345	COG2197	response regulator
K6749_19355	COG3706	GGDEF domain
K6749_19360	COG2197	response regulator
K6749_19365	COG5001	Diguanylate cyclase
K6749_19365	COG3300	MHYT domain
K6749_19375	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K6749_19395	COG0456	acetyltransferase
K6749_19395	COG1214	PFAM Peptidase M22, glycoprotease
K6749_19405	COG3069	C4-dicarboxylate transmembrane transporter activity
K6749_19430	COG3111	PFAM Bacterial OB fold (BOF) protein
K6749_19435	COG1597	lipid kinase activity
K6749_19440	COG0583	DNA-binding transcription factor activity
K6749_19445	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6749_19475	COG0714	Associated with various cellular activities
K6749_19480	COG0641	radical SAM
K6749_19485	COG3119	arylsulfatase activity
K6749_19495	COG3119	arylsulfatase activity
K6749_19500	COG0745	RESPONSE REGULATOR receiver
K6749_19515	COG2198	Histidine kinase
K6749_19515	COG0784	Response regulator, receiver
K6749_19515	COG2205	protein histidine kinase activity
K6749_19520	COG1879	ABC-type sugar transport system periplasmic component
K6749_19525	COG1803	Methylglyoxal synthase
K6749_19530	COG0210	DNA helicase
K6749_19535	COG1289	transmembrane transporter activity
K6749_19565	COG1629	transport
K6749_19565	COG4771	TonB-dependent receptor
K6749_19575	COG0789	Transcriptional regulator
K6749_19580	COG4604	ABC transporter, ATP-binding protein
K6749_19585	COG4605	iron ion homeostasis
K6749_19590	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6749_19595	COG4607	ABC-type enterochelin transport system periplasmic component
K6749_19605	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
K6749_19615	COG1609	Transcriptional regulator
K6749_19620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6749_19625	COG1879	ABC-type sugar transport system periplasmic component
K6749_19630	COG1172	Belongs to the binding-protein-dependent transport system permease family
K6749_19635	COG1129	ABC transporter
K6749_19640	COG1869	D-ribose catabolic process
K6749_19645	COG5001	Diguanylate cyclase
K6749_19700	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K6749_19710	COG2205	protein histidine kinase activity
K6749_19710	COG0784	Response regulator, receiver
K6749_19725	COG0330	HflC and HflK could
K6749_19740	COG0517	IMP dehydrogenase activity
K6749_19740	COG4175	Glycine betaine
K6749_19745	COG4176	ABC-type proline glycine betaine transport system permease component
K6749_19760	COG1012	belongs to the aldehyde dehydrogenase family
K6749_19765	COG1309	transcriptional regulator
K6749_19775	COG1028	Short-chain dehydrogenase reductase Sdr
K6749_19790	COG1024	Enoyl-CoA hydratase
K6749_19795	COG1960	acyl-CoA dehydrogenase activity
K6749_19805	COG0183	Belongs to the thiolase family
K6749_19815	COG1960	acyl-CoA dehydrogenase activity
K6749_19820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K6749_19830	COG4770	biotin carboxylase activity
K6749_19845	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K6749_19845	COG3264	Mechanosensitive ion channel
K6749_19850	COG0110	maltose O-acetyltransferase activity
K6749_19855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6749_19860	COG1271	oxidase subunit
K6749_19865	COG1294	oxidase, subunit
K6749_19875	COG0384	phenazine biosynthesis protein PhzF
K6749_19885	COG3527	Alpha-acetolactate decarboxylase
K6749_19900	COG0500	methyltransferase
K6749_19930	COG1022	Amp-dependent synthetase and ligase
K6749_19955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6749_19960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6749_19960	COG1263	PTS System
K6749_19965	COG1486	melibiose metabolic process
K6749_19970	COG2188	Transcriptional regulator
K6749_19975	COG1320	monovalent cation:proton antiporter activity
K6749_19980	COG2212	antiporter activity
K6749_19985	COG1863	multisubunit Na H antiporter MnhE subunit
K6749_19990	COG0651	ATP synthesis coupled electron transport
K6749_19995	COG1006	Multisubunit Na H antiporter MnhC subunit
K6749_20000	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K6749_20000	COG2111	Na H antiporter
K6749_20010	COG0589	response to stress
K6749_20015	COG4221	oxidoreductase activity
K6749_20020	COG0583	DNA-binding transcription factor activity
K6749_20030	COG2814	Major facilitator Superfamily
K6749_20095	COG1522	sequence-specific DNA binding
K6749_20130	COG0515	serine threonine protein kinase
K6749_20155	COG3501	Rhs element vgr protein
K6749_20195	COG0739	heme binding
K6749_20210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6749_20260	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K6749_20270	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K6749_20270	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K6749_20285	COG4989	oxidoreductase activity
K6749_20300	COG0038	chloride channel
K6749_20335	COG2897	thiosulfate sulfurtransferase activity
K6749_20345	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K6749_20350	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K6749_20360	COG2814	Major facilitator Superfamily
K6749_20365	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K6749_20375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6749_20385	COG0840	transmembrane signaling receptor activity
K6749_20405	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6749_20420	COG2197	response regulator
K6749_20425	COG3850	Histidine kinase
K6749_20430	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K6749_20440	COG0243	molybdopterin cofactor binding
K6749_20450	COG3005	denitrification pathway
K6749_20460	COG3243	poly(R)-hydroxyalkanoic acid synthase
K6749_20470	COG0183	Belongs to the thiolase family
K6749_20480	COG1280	lysine exporter protein (LysE YggA)
K6749_20490	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6749_20495	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6749_20545	COG1846	Transcriptional regulator
K6749_20550	COG0784	Response regulator, receiver
K6749_20550	COG2205	protein histidine kinase activity
K6749_20555	COG1879	ABC-type sugar transport system periplasmic component
K6749_20560	COG2827	Endonuclease containing a URI domain
K6749_20565	COG3132	Protein of unknown function, DUF480
K6749_20585	COG0784	Response regulator, receiver
K6749_20585	COG2205	protein histidine kinase activity
K6749_20585	COG5002	protein histidine kinase activity
K6749_20610	COG0583	DNA-binding transcription factor activity
K6749_20620	COG0531	amino acid
K6749_20635	COG2205	protein histidine kinase activity
K6749_20640	COG0745	RESPONSE REGULATOR receiver
K6749_20670	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K6749_20675	COG2239	Acts as a magnesium transporter
K6749_20680	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K6749_20685	COG0402	S-adenosylhomocysteine deaminase activity
K6749_20690	COG1418	mRNA catabolic process
K6749_20700	COG2814	Major facilitator Superfamily
K6749_20710	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6749_20730	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K6749_20745	COG0745	RESPONSE REGULATOR receiver
K6749_20750	COG2205	protein histidine kinase activity
K6749_20760	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K6749_20765	COG2194	sulfuric ester hydrolase activity
K6749_20785	COG4667	esterase of the alpha-beta hydrolase superfamily
K6749_20790	COG1741	Belongs to the pirin family
K6749_20795	COG1278	Cold shock
K6749_20810	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K6749_20815	COG0678	peroxiredoxin activity
K6749_20815	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K6749_20825	COG1686	Belongs to the peptidase S11 family
K6749_20830	COG0625	glutathione transferase activity
K6749_20835	COG1621	beta-fructofuranosidase activity
K6749_20840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6749_20845	COG1263	PTS System
K6749_20845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6749_20865	COG4771	TonB-dependent receptor
K6749_20870	COG0583	DNA-binding transcription factor activity
K6749_20880	COG1404	Belongs to the peptidase S8 family
K6749_20885	COG1028	Short-chain dehydrogenase reductase Sdr
K6749_20900	COG3746	phosphate-selective porin O and P
K6749_20915	COG0300	oxidoreductase activity
K6749_20920	COG0583	DNA-binding transcription factor activity
K6749_20925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6749_20925	COG2207	Transcriptional regulator
K6749_20930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6749_20955	COG0513	Belongs to the DEAD box helicase family
K6749_20965	COG0583	DNA-binding transcription factor activity
K6749_20980	COG1902	pentaerythritol trinitrate reductase activity
K6749_20985	COG1063	alcohol dehydrogenase
K6749_20995	COG1028	Short-chain dehydrogenase reductase Sdr
K6749_21005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6749_21010	COG0006	proline dipeptidase activity
K6749_21015	COG3608	succinylglutamate desuccinylase aspartoacylase
K6749_21020	COG1522	sequence-specific DNA binding
K6749_21025	COG1012	belongs to the aldehyde dehydrogenase family
K6749_21030	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K6749_21035	COG3122	Protein conserved in bacteria
K6749_21050	COG0583	DNA-binding transcription factor activity
K6749_21055	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K6749_21060	COG0252	asparaginase activity
K6749_21065	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K6749_21080	COG2197	response regulator
K6749_21085	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K6749_21110	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6749_21140	COG3842	ATPase activity
K6749_21160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6749_21225	COG0583	DNA-binding transcription factor activity
K6749_21235	COG4948	Mandelate Racemase Muconate Lactonizing
K6749_21265	COG1342	Belongs to the UPF0251 family
K6749_21270	COG4176	ABC-type proline glycine betaine transport system permease component
K6749_21275	COG3448	diguanylate cyclase activity
K6749_21275	COG4175	Glycine betaine
K6749_21280	COG3015	lipoprotein NlpE involved in copper resistance
K6749_21285	COG3713	MltA-interacting MipA family protein
K6749_21300	COG0583	DNA-binding transcription factor activity
K6749_21325	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K6749_21335	COG1335	isochorismatase
K6749_21350	COG1349	DNA-binding transcription factor activity
K6749_21355	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6749_21355	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6749_21360	COG2070	2-Nitropropane dioxygenase
K6749_21365	COG0531	amino acid
K6749_21370	COG4302	ethanolamine ammonia-lyase activity
K6749_21375	COG4303	Ethanolamine ammonia lyase large subunit
K6749_21385	COG1309	transcriptional regulator
K6749_21405	COG1280	lysine exporter protein (LysE YggA)
K6749_21415	COG0459	protein refolding
K6749_21420	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K6749_21425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6749_21440	COG1304	FMN binding
K6749_21465	COG1256	bacterial-type flagellum assembly
K6749_21465	COG4786	Flagellar basal body rod
K6749_21475	COG1706	bacterial-type flagellum-dependent cell motility
K6749_21480	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K6749_21485	COG4786	Flagellar basal body rod
K6749_21490	COG4787	bacterial-type flagellum-dependent cell motility
K6749_21505	COG1558	bacterial-type flagellum-dependent cell motility
K6749_21510	COG1815	bacterial-type flagellum-dependent cell motility
K6749_21530	COG0741	lytic transglycosylase activity
K6749_21530	COG1388	LysM domain
K6749_21535	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K6749_21555	COG1760	l-serine dehydratase
K6749_21570	COG0583	DNA-binding transcription factor activity
K6749_21580	COG2866	Carboxypeptidase
K6749_21595	COG2990	Protein conserved in bacteria
K6749_21620	COG3842	ATPase activity
K6749_21625	COG1840	ABC-type Fe3 transport system, periplasmic component
K6749_21635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K6749_21655	COG3240	lipase activity
K6749_21660	COG1309	transcriptional regulator
K6749_21675	COG1136	(ABC) transporter
K6749_21675	COG0577	efflux transmembrane transporter activity
K6749_21680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6749_21685	COG2067	long-chain fatty acid transport protein
K6749_21695	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K6749_21710	COG1011	Hydrolase
K6749_21745	COG0110	maltose O-acetyltransferase activity
K6749_21750	COG1765	OsmC-like protein
K6749_21755	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6749_21755	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6749_21770	COG3046	protein related to deoxyribodipyrimidine photolyase
K6749_21775	COG0415	Belongs to the DNA photolyase family
K6749_21780	COG3706	GGDEF domain
K6749_21795	COG3706	GGDEF domain
K6749_21810	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6749_21825	COG3033	Beta-eliminating lyase
K6749_21835	COG1271	oxidase subunit
K6749_21840	COG1294	oxidase, subunit
K6749_21860	COG0579	oxidoreductase
K6749_21880	COG3706	GGDEF domain
K6749_21890	COG4191	Histidine kinase
K6749_21910	COG0583	DNA-binding transcription factor activity
K6749_21930	COG0189	ligase activity
K6749_21935	COG0189	ligase activity
K6749_21935	COG4067	protein conserved in archaea
K6749_21945	COG1166	arginine decarboxylase activity
K6749_21950	COG0010	Belongs to the arginase family
K6749_21955	COG2814	Major facilitator Superfamily
K6749_21960	COG1770	oligopeptidase
K6749_21975	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K6749_21980	COG1121	(ABC) transporter
K6749_21985	COG0803	Belongs to the bacterial solute-binding protein 9 family
K6749_22030	COG0848	biopolymer transport protein
K6749_22035	COG0811	peptide transport
K6749_22040	COG0811	peptide transport
K6749_22055	COG2205	protein histidine kinase activity
K6749_22060	COG0745	RESPONSE REGULATOR receiver
K6749_22065	COG0584	glycerophosphoryl diester phosphodiesterase
K6749_22075	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6749_22135	COG1901	pseudouridine methyltransferase
K6749_22140	COG0312	modulator of DNA gyrase
K6749_22145	COG0312	modulator of DNA gyrase
K6749_22150	COG0351	phosphomethylpyrimidine kinase
K6749_22155	COG1116	anion transmembrane transporter activity
K6749_22160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6749_22165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K6749_22170	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K6749_22180	COG0352	thiamine-phosphate diphosphorylase activity
K6749_22190	COG0243	molybdopterin cofactor binding
K6749_22195	COG3005	denitrification pathway
K6749_22200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6749_22205	COG1028	Short-chain dehydrogenase reductase Sdr
K6749_22220	COG0456	acetyltransferase
K6749_22240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6749_22245	COG1929	Belongs to the glycerate kinase type-1 family
K6749_22250	COG2610	gluconate transmembrane transporter activity
K6749_22255	COG3835	regulator
K6749_22295	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
K6749_22300	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
K6749_22300	COG3408	Glycogen debranching enzyme
K6749_22330	COG3047	cAMP biosynthetic process
K6749_22335	COG1357	PFAM Pentapeptide repeats (8 copies)
K6749_22365	COG2375	cellular response to nickel ion
K6749_22370	COG0583	DNA-binding transcription factor activity
K6749_22375	COG2162	N-hydroxyarylamine O-acetyltransferase activity
K6749_22380	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K6749_22395	COG2199	diguanylate cyclase activity
K6749_22405	COG0561	phosphatase activity
K6749_22410	COG0583	DNA-binding transcription factor activity
K6749_22425	COG0564	pseudouridine synthase activity
K6749_22430	COG0534	Mate efflux family protein
K6749_22445	COG3123	guanosine phosphorylase activity
K6749_22460	COG0596	Alpha beta hydrolase
K6749_22485	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6749_22495	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K6749_22500	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K6749_22500	COG2169	Transcriptional regulator
K6749_22510	COG2259	Doxx family
K6749_22515	COG1741	Belongs to the pirin family
K6749_22535	COG0363	glucosamine-6-phosphate deaminase activity
K6749_22545	COG0786	glutamate:sodium symporter activity
K6749_22550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6749_22555	COG1131	(ABC) transporter
K6749_22565	COG0786	glutamate:sodium symporter activity
K6749_22585	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K6749_22590	COG3279	Response regulator of the LytR AlgR family
K6749_22595	COG3275	phosphorelay sensor kinase activity
K6749_22625	COG0772	Belongs to the SEDS family
K6749_22650	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
K6749_22650	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6749_22660	COG0444	Belongs to the ABC transporter superfamily
K6749_22665	COG4608	Belongs to the ABC transporter superfamily
K6749_22690	COG1444	tRNA N-acetyltransferase activity
K6749_22710	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6749_22715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6749_22715	COG1263	PTS System
K6749_22720	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K6749_22735	COG4166	transmembrane transport
K6749_22780	COG0259	pyridoxamine-phosphate oxidase activity
K6749_22805	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6749_22840	COG1132	(ABC) transporter
K6749_22850	COG0513	Belongs to the DEAD box helicase family
K6749_22855	COG2258	MOSC domain
K6749_22905	COG3634	alkyl hydroperoxide reductase activity
K6749_22920	COG1846	Transcriptional regulator
K6749_22925	COG1764	response to oxidative stress
K6749_22955	COG0577	efflux transmembrane transporter activity
K6749_22960	COG1136	(ABC) transporter
K6749_22970	COG0826	peptidase U32
K6749_22980	COG0019	diaminopimelate decarboxylase activity
K6749_22985	COG4264	IucA IucC family
K6749_23010	COG4772	TonB-dependent receptor
K6749_23015	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K6749_23020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6749_23025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6749_23030	COG1120	ATPase activity
K6749_23035	COG0840	transmembrane signaling receptor activity
K6749_23040	COG0612	Peptidase, M16
K6749_23050	COG0739	heme binding
K6749_23065	COG2814	Major facilitator Superfamily
K6749_23075	COG1609	Transcriptional regulator
K6749_23080	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6749_23095	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K6749_23095	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K6749_23105	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K6749_23110	COG1609	Transcriptional regulator
K6749_23120	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K6749_23160	COG1760	l-serine dehydratase
K6749_23170	COG4580	involved in the transport of maltose and maltodextrins
K6749_23190	COG2356	endonuclease I
K6749_23210	COG1982	Orn Lys Arg decarboxylase major
K6749_23215	COG0531	amino acid
K6749_23225	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K6749_23230	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
K6749_23235	COG1162	GTPase activity
K6749_23240	COG1263	PTS System
K6749_23240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6749_23245	COG1999	signal sequence binding
K6749_23260	COG2909	trisaccharide binding
K6749_23265	COG0058	SHG alpha-glucan phosphorylase activity
K6749_23270	COG1640	4-alpha-glucanotransferase
K6749_23275	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K6749_23280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6749_23285	COG0366	Alpha amylase catalytic
K6749_23300	COG3366	ferrous iron transmembrane transporter activity
K6749_23305	COG0700	Nucleoside recognition
K6749_23310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6749_23315	COG3339	Conserved Protein
K6749_23320	COG1301	dicarboxylic acid transport
K6749_23330	COG0583	DNA-binding transcription factor activity
K6749_23350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K6749_23355	COG1596	polysaccharide export
K6749_23370	COG2095	MarC family integral membrane protein
K6749_23375	COG4667	esterase of the alpha-beta hydrolase superfamily
K6749_23380	COG3397	chitin binding
K6749_23385	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K6749_23390	COG0415	Belongs to the DNA photolyase family
K6749_23400	COG1054	Belongs to the UPF0176 family
K6749_23410	COG1686	Belongs to the peptidase S11 family
K6749_23435	COG0583	DNA-binding transcription factor activity
K6749_23440	COG4628	conserved protein (DUF2132)
K6749_23460	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K6749_23465	COG0628	permease
K6749_23505	COG2814	Major facilitator Superfamily
K6749_23515	COG0454	-acetyltransferase
K6749_23525	COG0745	RESPONSE REGULATOR receiver
K6749_23530	COG2205	protein histidine kinase activity
K6749_23545	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K6749_23550	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K6749_23665	COG1192	Involved in chromosome partitioning