locus-tag	class	description
K04M1_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K04M1_00020	COG0592	DNA-directed DNA polymerase activity
K04M1_00040	COG0187	DNA topoisomerase II activity
K04M1_00070	COG0071	Belongs to the small heat shock protein (HSP20) family
K04M1_00080	COG3977	Valine--pyruvate aminotransferase
K04M1_00090	COG0366	Alpha amylase catalytic
K04M1_00120	COG2119	membrane
K04M1_00140	COG0425	Belongs to the sulfur carrier protein TusA family
K04M1_00170	COG0604	alcohol dehydrogenase
K04M1_00180	COG0183	Belongs to the thiolase family
K04M1_00200	COG1739	Uncharacterized protein family UPF0029
K04M1_00210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K04M1_00290	COG0583	DNA-binding transcription factor activity
K04M1_00300	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K04M1_00310	COG2960	long-chain fatty acid transporting porin activity
K04M1_00320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K04M1_00330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K04M1_00430	COG4172	Belongs to the ABC transporter superfamily
K04M1_00440	COG4166	transmembrane transport
K04M1_00460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K04M1_00480	COG1609	Transcriptional regulator
K04M1_00490	COG0583	DNA-binding transcription factor activity
K04M1_00510	COG2076	Multidrug Resistance protein
K04M1_00520	COG0129	dihydroxy-acid dehydratase activity
K04M1_00530	COG3265	gluconokinase activity
K04M1_00540	COG2610	gluconate transmembrane transporter activity
K04M1_00550	COG0800	Aldolase
K04M1_00560	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K04M1_00570	COG0583	DNA-binding transcription factor activity
K04M1_00580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K04M1_00590	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K04M1_00610	COG1522	sequence-specific DNA binding
K04M1_00620	COG5001	Diguanylate cyclase
K04M1_00620	COG5002	protein histidine kinase activity
K04M1_00630	COG0742	ribosomal rna small subunit methyltransferase
K04M1_00650	COG0697	spore germination
K04M1_00660	COG0589	response to stress
K04M1_00670	COG1528	Iron-storage protein
K04M1_00690	COG2081	HI0933 family
K04M1_00750	COG1597	lipid kinase activity
K04M1_00810	COG0628	permease
K04M1_00840	COG1322	Protein conserved in bacteria
K04M1_00850	COG2226	methyltransferase
K04M1_00860	COG3165	ubiquinone biosynthetic process from chorismate
K04M1_00870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K04M1_00900	COG0805	protein transport
K04M1_00910	COG0084	hydrolase, TatD family'
K04M1_00930	COG0456	acetyltransferase
K04M1_00950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K04M1_00950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K04M1_00960	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K04M1_01010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K04M1_01020	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K04M1_01040	COG2204	response regulator
K04M1_01050	COG3852	Histidine kinase
K04M1_01070	COG0174	glutamine synthetase
K04M1_01090	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K04M1_01110	COG1295	ribonuclease BN
K04M1_01120	COG1490	D-aminoacyl-tRNA deacylase activity
K04M1_01130	COG0456	acetyltransferase
K04M1_01150	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K04M1_01160	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K04M1_01170	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K04M1_01180	COG3031	protein transport across the cell outer membrane
K04M1_01200	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K04M1_01210	COG1459	type II secretion system
K04M1_01220	COG2165	general secretion pathway protein
K04M1_01230	COG2165	general secretion pathway protein
K04M1_01240	COG2165	general secretion pathway protein
K04M1_01250	COG4795	General secretion pathway protein
K04M1_01260	COG3156	type II secretion system protein K
K04M1_01270	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K04M1_01280	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K04M1_01300	COG1218	3'(2'),5'-bisphosphate nucleotidase
K04M1_01310	COG0494	nUDIX hydrolase
K04M1_01330	COG1040	competence protein
K04M1_01360	COG2183	response to ionizing radiation
K04M1_01380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K04M1_01400	COG0745	RESPONSE REGULATOR receiver
K04M1_01410	COG2205	protein histidine kinase activity
K04M1_01420	COG2233	PERMEase
K04M1_01430	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K04M1_01440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K04M1_01450	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K04M1_01460	COG1758	RNA polymerase activity
K04M1_01470	COG0194	GDP metabolic process
K04M1_01500	COG0848	biopolymer transport protein
K04M1_01510	COG0811	peptide transport
K04M1_01550	COG4174	ABC transporter (Permease)
K04M1_01560	COG4239	(ABC) transporter, permease
K04M1_01570	COG0747	negative chemotaxis
K04M1_01580	COG0444	Belongs to the ABC transporter superfamily
K04M1_01590	COG4608	Belongs to the ABC transporter superfamily
K04M1_01610	COG1561	YicC-like family, N-terminal region
K04M1_01620	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K04M1_01630	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K04M1_01640	COG1560	Kdo2-lipid A biosynthetic process
K04M1_01650	COG1309	transcriptional regulator
K04M1_01660	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K04M1_01680	COG2003	Belongs to the UPF0758 family
K04M1_01730	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K04M1_01760	COG0463	Glycosyl transferase, family 2
K04M1_01770	COG0859	PFAM glycosyl transferase family 9
K04M1_01780	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K04M1_01790	COG3642	lipopolysaccharide core region biosynthetic process
K04M1_01810	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K04M1_01890	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K04M1_01900	COG1519	Transferase
K04M1_01910	COG0859	PFAM glycosyl transferase family 9
K04M1_01930	COG1560	Kdo2-lipid A biosynthetic process
K04M1_02110	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K04M1_02220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K04M1_02230	COG1519	Transferase
K04M1_02240	COG0859	PFAM glycosyl transferase family 9
K04M1_02260	COG1560	Kdo2-lipid A biosynthetic process
K04M1_02300	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K04M1_02400	COG0438	transferase activity, transferring glycosyl groups
K04M1_02420	COG0438	transferase activity, transferring glycosyl groups
K04M1_02420	COG0297	glycogen (starch) synthase activity
K04M1_02440	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K04M1_02450	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K04M1_02460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K04M1_02520	COG1215	transferase activity, transferring glycosyl groups
K04M1_02570	COG0149	triose-phosphate isomerase activity
K04M1_02620	COG1494	fructose-1,6-bisphosphatase
K04M1_02640	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K04M1_02650	COG1575	Belongs to the MenA family. Type 1 subfamily
K04M1_02710	COG2003	Belongs to the UPF0758 family
K04M1_02740	COG4565	transcriptional regulatory protein
K04M1_02760	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K04M1_02770	COG0511	ligase activity, forming carbon-carbon bonds
K04M1_02770	COG5016	pyruvate
K04M1_02780	COG3630	sodium ion export across plasma membrane
K04M1_02800	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
K04M1_02810	COG3052	prosthetic group binding
K04M1_02820	COG2301	Belongs to the HpcH HpaI aldolase family
K04M1_02830	COG3051	citrate lyase alpha subunit
K04M1_02840	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
K04M1_02850	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
K04M1_02880	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K04M1_02890	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K04M1_02920	COG1609	Transcriptional regulator
K04M1_02930	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K04M1_02940	COG0254	rRNA binding
K04M1_02960	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K04M1_02970	COG0088	Forms part of the polypeptide exit tunnel
K04M1_02990	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K04M1_03000	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K04M1_03010	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K04M1_03020	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K04M1_03040	COG0255	Belongs to the universal ribosomal protein uL29 family
K04M1_03050	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K04M1_03070	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K04M1_03080	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K04M1_03090	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K04M1_03100	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K04M1_03110	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K04M1_03140	COG1841	ribosomal large subunit assembly
K04M1_03160	COG0201	protein transport
K04M1_03180	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K04M1_03190	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K04M1_03210	COG0202	RNA polymerase activity
K04M1_03220	COG0203	ribosomal protein L17
K04M1_03240	COG0545	Peptidyl-prolyl cis-trans isomerase
K04M1_03260	COG2153	protein acetylation
K04M1_03270	COG0513	Belongs to the DEAD box helicase family
K04M1_03300	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K04M1_03300	COG1648	precorrin-2 dehydrogenase activity
K04M1_03310	COG0175	sulfate reduction
K04M1_03320	COG2895	sulfate adenylyltransferase (ATP) activity
K04M1_03330	COG0471	metal ion transport
K04M1_03330	COG3273	potassium ion transport
K04M1_03340	COG0529	Catalyzes the synthesis of activated sulfate
K04M1_03390	COG4181	ATPase activity
K04M1_03420	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K04M1_03440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K04M1_03450	COG0729	surface antigen
K04M1_03460	COG2911	Protein conserved in bacteria
K04M1_03470	COG2105	PFAM AIG2 family protein
K04M1_03490	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K04M1_03500	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K04M1_03510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K04M1_03520	COG0163	prenyltransferase activity
K04M1_03530	COG4143	(ABC) transporter
K04M1_03540	COG1178	ABC-type Fe3 transport system permease component
K04M1_03550	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K04M1_03560	COG0583	DNA-binding transcription factor activity
K04M1_03570	COG1902	pentaerythritol trinitrate reductase activity
K04M1_03640	COG0142	geranyltranstransferase activity
K04M1_03650	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K04M1_03670	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K04M1_03680	COG2966	Psort location CytoplasmicMembrane, score
K04M1_03700	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K04M1_03710	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K04M1_03720	COG2967	ApaG domain
K04M1_03730	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K04M1_03740	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K04M1_03750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K04M1_03760	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K04M1_03770	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K04M1_03810	COG0473	3-isopropylmalate dehydrogenase activity
K04M1_03820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K04M1_03860	COG0583	DNA-binding transcription factor activity
K04M1_03870	COG1022	Amp-dependent synthetase and ligase
K04M1_03880	COG0028	Belongs to the TPP enzyme family
K04M1_03890	COG0440	acetolactate synthase activity
K04M1_03900	COG3706	GGDEF domain
K04M1_03920	COG0469	pyruvate kinase activity
K04M1_03930	COG1349	DNA-binding transcription factor activity
K04M1_03940	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K04M1_03960	COG2376	Dihydroxyacetone kinase
K04M1_03970	COG1461	Dihydroxyacetone kinase
K04M1_04000	COG3722	fumarate hydratase activity
K04M1_04020	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K04M1_04020	COG2213	PTS system mannitol-specific
K04M1_04080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K04M1_04090	COG0358	DNA primase activity
K04M1_04100	COG1610	YqeY-like protein
K04M1_04110	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K04M1_04120	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K04M1_04130	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K04M1_04140	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K04M1_04150	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K04M1_04160	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K04M1_04170	COG1968	undecaprenyl-diphosphatase activity
K04M1_04190	COG3267	Type II secretory pathway component ExeA
K04M1_04190	COG3409	Peptidoglycan-binding domain 1 protein
K04M1_04210	COG0405	Gamma-glutamyltransferase
K04M1_04220	COG4991	sh3 domain protein
K04M1_04230	COG0306	phosphate transporter
K04M1_04240	COG1392	Phosphate transport regulator
K04M1_04250	COG3025	triphosphatase activity
K04M1_04280	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K04M1_04290	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K04M1_04290	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K04M1_04300	COG1538	Outer membrane efflux protein
K04M1_04310	COG0494	nUDIX hydrolase
K04M1_04320	COG3151	Protein conserved in bacteria
K04M1_04340	COG3150	esterase
K04M1_04350	COG0187	DNA topoisomerase II activity
K04M1_04360	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K04M1_04370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K04M1_04390	COG3105	Protein conserved in bacteria
K04M1_04400	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K04M1_04420	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K04M1_04430	COG0723	plastoquinol--plastocyanin reductase activity
K04M1_04440	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K04M1_04450	COG2857	Cytochrome c1
K04M1_04460	COG0625	glutathione transferase activity
K04M1_04470	COG2969	positive regulation of protein catabolic process
K04M1_04500	COG2823	Periplasmic or secreted lipoprotein
K04M1_04510	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K04M1_04540	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K04M1_04560	COG3116	cell division
K04M1_04570	COG0768	penicillin binding
K04M1_04580	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K04M1_04590	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K04M1_04600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K04M1_04610	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K04M1_04620	COG0772	Belongs to the SEDS family
K04M1_04650	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K04M1_04660	COG0849	cell division
K04M1_04670	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K04M1_04680	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K04M1_04700	COG0653	protein targeting
K04M1_04710	COG0494	nUDIX hydrolase
K04M1_04730	COG0505	Belongs to the CarA family
K04M1_04740	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K04M1_04770	COG0730	response to heat
K04M1_04780	COG0583	DNA-binding transcription factor activity
K04M1_04790	COG2860	membrane
K04M1_04820	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K04M1_04840	COG0493	'glutamate synthase
K04M1_04850	COG0070	glutamate synthase
K04M1_04850	COG0069	glutamate synthase activity
K04M1_04850	COG0067	glutamate synthase
K04M1_04870	COG0067	glutamate synthase
K04M1_04870	COG0069	glutamate synthase activity
K04M1_04870	COG0070	glutamate synthase
K04M1_04880	COG1242	4 iron, 4 sulfur cluster binding
K04M1_04890	COG5001	Diguanylate cyclase
K04M1_04890	COG4251	negative regulation of phosphorylation
K04M1_04890	COG3706	GGDEF domain
K04M1_04890	COG2203	Gaf domain
K04M1_04900	COG0784	Response regulator, receiver
K04M1_04900	COG5002	protein histidine kinase activity
K04M1_04900	COG2198	Histidine kinase
K04M1_04920	COG0745	RESPONSE REGULATOR receiver
K04M1_04940	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K04M1_04970	COG0083	homoserine kinase activity
K04M1_04980	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K04M1_05000	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
K04M1_05010	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K04M1_05020	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K04M1_05050	COG1115	amino acid carrier protein
K04M1_05060	COG3022	response to hydroperoxide
K04M1_05070	COG0513	Belongs to the DEAD box helicase family
K04M1_05080	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K04M1_05100	COG0716	FMN binding
K04M1_05120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K04M1_05130	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K04M1_05140	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K04M1_05160	COG2204	response regulator
K04M1_05190	COG0667	Aldo Keto reductase
K04M1_05240	COG0730	response to heat
K04M1_05260	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K04M1_05280	COG1283	sodium-dependent phosphate transmembrane transporter activity
K04M1_05290	COG0583	DNA-binding transcription factor activity
K04M1_05300	COG0640	Transcriptional regulator
K04M1_05310	COG0268	Binds directly to 16S ribosomal RNA
K04M1_05320	COG0728	peptidoglycan biosynthetic process
K04M1_05330	COG0196	riboflavin kinase activity
K04M1_05360	COG1047	Peptidyl-prolyl cis-trans
K04M1_05370	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K04M1_05390	COG3279	Response regulator of the LytR AlgR family
K04M1_05400	COG3275	phosphorelay sensor kinase activity
K04M1_05410	COG1966	Carbon starvation protein
K04M1_05450	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K04M1_05460	COG1472	Belongs to the glycosyl hydrolase 3 family
K04M1_05470	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K04M1_05480	COG1605	Chorismate mutase
K04M1_05480	COG0287	Prephenate dehydrogenase
K04M1_05490	COG0739	heme binding
K04M1_05510	COG0488	(ABC) transporter
K04M1_05530	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
K04M1_05540	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
K04M1_05550	COG1605	Chorismate mutase
K04M1_05550	COG0077	Prephenate dehydratase
K04M1_05560	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K04M1_05580	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K04M1_05590	COG0564	pseudouridine synthase activity
K04M1_05610	COG0542	response to heat
K04M1_05740	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K04M1_05760	COG2974	May be involved in recombination
K04M1_05770	COG0745	RESPONSE REGULATOR receiver
K04M1_05780	COG5002	protein histidine kinase activity
K04M1_05800	COG0248	Ppx GppA phosphatase
K04M1_05810	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K04M1_05820	COG0573	inorganic phosphate transmembrane transporter activity
K04M1_05830	COG0581	inorganic phosphate transmembrane transporter activity
K04M1_05840	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K04M1_05850	COG0704	Plays a role in the regulation of phosphate uptake
K04M1_05870	COG3142	Participates in the control of copper homeostasis
K04M1_05880	COG0450	alkyl hydroperoxide reductase
K04M1_05890	COG0583	DNA-binding transcription factor activity
K04M1_05900	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K04M1_05920	COG0517	IMP dehydrogenase activity
K04M1_05940	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K04M1_05960	COG1862	Preprotein translocase
K04M1_05970	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K04M1_05980	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K04M1_06010	COG0483	inositol monophosphate 1-phosphatase activity
K04M1_06020	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
K04M1_06040	COG1104	cysteine desulfurase activity
K04M1_06050	COG0822	iron-sulfur transferase activity
K04M1_06080	COG0443	Heat shock 70 kDa protein
K04M1_06090	COG0633	Ferredoxin
K04M1_06100	COG2975	iron-sulfur cluster assembly
K04M1_06120	COG0105	UTP biosynthetic process
K04M1_06150	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K04M1_06160	COG0124	histidyl-tRNA synthetase
K04M1_06170	COG2976	Protein conserved in bacteria
K04M1_06180	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K04M1_06190	COG1160	GTP binding
K04M1_06230	COG0517	IMP dehydrogenase activity
K04M1_06230	COG0516	GMP reductase activity
K04M1_06250	COG0582	viral genome integration into host DNA
K04M1_06390	COG1757	Na H antiporter
K04M1_06410	COG1584	GPR1 FUN34 yaaH family protein
K04M1_06420	COG1115	amino acid carrier protein
K04M1_06450	COG2873	o-acetylhomoserine
K04M1_06460	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K04M1_06500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K04M1_06500	COG3153	acetyltransferase
K04M1_06510	COG0583	DNA-binding transcription factor activity
K04M1_06550	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K04M1_06560	COG2867	negative regulation of translational initiation
K04M1_06570	COG2914	Belongs to the UPF0125 (RnfH) family
K04M1_06580	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K04M1_06600	COG0497	DNA recombination
K04M1_06620	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K04M1_06630	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K04M1_06650	COG1301	dicarboxylic acid transport
K04M1_06670	COG0484	heat shock protein binding
K04M1_06730	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K04M1_06740	COG0590	tRNA wobble adenosine to inosine editing
K04M1_06750	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K04M1_06760	COG0047	phosphoribosylformylglycinamidine synthase activity
K04M1_06760	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K04M1_06820	COG2195	Cleaves the N-terminal amino acid of tripeptides
K04M1_06830	COG2252	PERMEase
K04M1_06840	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K04M1_06870	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K04M1_06880	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K04M1_06890	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K04M1_06900	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K04M1_06900	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K04M1_06950	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K04M1_06960	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K04M1_06970	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K04M1_06980	COG0142	geranyltranstransferase activity
K04M1_06990	COG1722	exodeoxyribonuclease VII activity
K04M1_07000	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K04M1_07020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K04M1_07020	COG0301	tRNA thio-modification
K04M1_07030	COG0583	DNA-binding transcription factor activity
K04M1_07050	COG2363	Small membrane protein
K04M1_07070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K04M1_07080	COG1611	Belongs to the LOG family
K04M1_07090	COG3706	GGDEF domain
K04M1_07090	COG0745	RESPONSE REGULATOR receiver
K04M1_07110	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K04M1_07110	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K04M1_07130	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
K04M1_07140	COG1464	Belongs to the NlpA lipoprotein family
K04M1_07150	COG2011	ABC-type metal ion transport system permease component
K04M1_07160	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K04M1_07170	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K04M1_07190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K04M1_07190	COG1263	PTS System
K04M1_07200	COG0366	Alpha amylase catalytic
K04M1_07230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K04M1_07240	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K04M1_07250	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K04M1_07260	COG0321	lipoyl(octanoyl) transferase activity
K04M1_07280	COG1686	Belongs to the peptidase S11 family
K04M1_07290	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K04M1_07300	COG0772	Belongs to the SEDS family
K04M1_07310	COG0768	penicillin binding
K04M1_07320	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K04M1_07330	COG0799	negative regulation of ribosome biogenesis
K04M1_07340	COG1466	dna polymerase III delta subunit
K04M1_07350	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
K04M1_07360	COG0495	leucyl-tRNA aminoacylation
K04M1_07370	COG2888	peptidyl-tyrosine sulfation
K04M1_07380	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K04M1_07390	COG4535	Mg2 and Co2 transporter CorC
K04M1_07400	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K04M1_07410	COG1702	phosphate starvation-inducible protein PhoH
K04M1_07420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K04M1_07430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K04M1_07640	COG0012	GTP binding
K04M1_07650	COG0193	aminoacyl-tRNA hydrolase activity
K04M1_07660	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K04M1_07670	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K04M1_07680	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K04M1_07690	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K04M1_07710	COG2890	protein-(glutamine-N5) methyltransferase activity
K04M1_07720	COG3094	Invasion gene expression up-regulator, SirB
K04M1_07730	COG2912	Transglutaminase-like superfamily
K04M1_07740	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K04M1_07750	COG0737	Belongs to the 5'-nucleotidase family
K04M1_07760	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K04M1_07770	COG1187	pseudouridine synthase activity
K04M1_07780	COG2840	Smr protein MutS2
K04M1_07860	COG2217	Heavy metal translocating P-type atpase
K04M1_07860	COG2608	mercury ion transmembrane transporter activity
K04M1_07880	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K04M1_07990	COG0835	chemotaxis
K04M1_07990	COG0784	Response regulator, receiver
K04M1_08000	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K04M1_08010	COG1815	bacterial-type flagellum-dependent cell motility
K04M1_08020	COG1558	bacterial-type flagellum-dependent cell motility
K04M1_08030	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K04M1_08040	COG1749	Flagellar hook protein flgE
K04M1_08050	COG4787	bacterial-type flagellum-dependent cell motility
K04M1_08060	COG4786	Flagellar basal body rod
K04M1_08070	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K04M1_08080	COG1706	bacterial-type flagellum-dependent cell motility
K04M1_08090	COG3951	Flagellar rod assembly protein muramidase FlgJ
K04M1_08090	COG1705	Flagellar rod assembly protein muramidase FlgJ
K04M1_08110	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K04M1_08120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K04M1_08130	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K04M1_08140	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K04M1_08150	COG2190	(PTS) system
K04M1_08160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K04M1_08180	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K04M1_08190	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K04M1_08200	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
K04M1_08210	COG3115	cell septum assembly
K04M1_08220	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K04M1_08270	COG0330	HflC and HflK could
K04M1_08280	COG2194	sulfuric ester hydrolase activity
K04M1_08320	COG1192	Involved in chromosome partitioning
K04M1_08330	COG1215	transferase activity, transferring glycosyl groups
K04M1_08350	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
K04M1_08360	COG0457	Tetratricopeptide repeat
K04M1_08360	COG3118	belongs to the thioredoxin family
K04M1_08370	COG3118	belongs to the thioredoxin family
K04M1_08380	COG0300	oxidoreductase activity
K04M1_08390	COG1090	epimerase
K04M1_08450	COG0622	Phosphoesterase
K04M1_08490	COG3710	Transcriptional regulator
K04M1_08500	COG0326	Molecular chaperone. Has ATPase activity
K04M1_08520	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K04M1_08530	COG3104	oligopeptide transport
K04M1_08540	COG0250	Participates in transcription elongation, termination and antitermination
K04M1_08550	COG0367	asparagine synthase
K04M1_08560	COG4651	solute:proton antiporter activity
K04M1_08560	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K04M1_08570	COG1940	carbohydrate kinase activity
K04M1_08570	COG1846	Transcriptional regulator
K04M1_08580	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K04M1_08590	COG2190	(PTS) system
K04M1_08590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K04M1_08590	COG1263	PTS System
K04M1_08600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K04M1_08610	COG0735	belongs to the Fur family
K04M1_08630	COG0716	FMN binding
K04M1_08650	COG0596	Alpha beta hydrolase
K04M1_08660	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
K04M1_08670	COG0033	Phosphoglucomutase
K04M1_08690	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K04M1_08710	COG2009	succinate dehydrogenase
K04M1_08720	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K04M1_08730	COG1053	succinate dehydrogenase
K04M1_08740	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K04M1_08750	COG0567	Dehydrogenase, E1 component
K04M1_08760	COG0508	dehydrogenase complex catalyzes the overall conversion of
K04M1_08770	COG0045	succinate-CoA ligase (ADP-forming) activity
K04M1_08790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K04M1_08800	COG1121	(ABC) transporter
K04M1_08810	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
K04M1_08820	COG4977	sequence-specific DNA binding
K04M1_08830	COG1918	ferrous iron import across plasma membrane
K04M1_08880	COG0018	arginyl-trna synthetase
K04M1_08890	COG3102	Protein conserved in bacteria
K04M1_08920	COG0788	formyltetrahydrofolate deformylase activity
K04M1_08930	COG1199	ATP-dependent helicase activity
K04M1_08940	COG1214	PFAM Peptidase M22, glycoprotease
K04M1_08960	COG3065	identical protein binding
K04M1_08970	COG2267	carboxylic ester hydrolase activity
K04M1_08980	COG0318	PFAM AMP-dependent synthetase and ligase
K04M1_08990	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K04M1_09010	COG2894	cell division
K04M1_09020	COG0850	regulation of cytokinetic process
K04M1_09030	COG3100	YcgL domain-containing protein
K04M1_09040	COG2951	lytic endotransglycosylase activity
K04M1_09060	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K04M1_09070	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K04M1_09090	COG2226	methyltransferase
K04M1_09110	COG1028	Short-chain dehydrogenase reductase Sdr
K04M1_09120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K04M1_09130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K04M1_09180	COG2986	histidine ammonia-lyase
K04M1_09190	COG1216	Glycosyl transferase, family 2
K04M1_09200	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K04M1_09230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K04M1_09240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K04M1_09310	COG0513	Belongs to the DEAD box helicase family
K04M1_09320	COG0569	domain protein
K04M1_09330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K04M1_09370	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K04M1_09380	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K04M1_09390	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K04M1_09400	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K04M1_09440	COG0544	peptidyl-prolyl cis-trans isomerase activity
K04M1_09460	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K04M1_09470	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K04M1_09480	COG0776	regulation of translation
K04M1_09490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K04M1_09500	COG1555	photosystem II stabilization
K04M1_09530	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K04M1_09540	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K04M1_09550	COG0436	Aminotransferase
K04M1_09560	COG1169	isochorismate synthase
K04M1_09570	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K04M1_09590	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K04M1_09600	COG1441	menaquinone biosynthetic process
K04M1_09630	COG2855	membrane
K04M1_09640	COG0477	Major facilitator Superfamily
K04M1_09730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K04M1_09740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K04M1_09770	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K04M1_09780	COG1522	sequence-specific DNA binding
K04M1_09800	COG1946	Acyl-CoA thioesterase
K04M1_09810	COG3126	Type III secretion system lipoprotein chaperone (YscW)
K04M1_09840	COG3706	GGDEF domain
K04M1_09850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K04M1_09860	COG0516	GMP reductase activity
K04M1_09860	COG0517	IMP dehydrogenase activity
K04M1_09910	COG0537	adenosine 5'-monophosphoramidase activity
K04M1_09960	COG3150	esterase
K04M1_09970	COG1252	NADH dehydrogenase
K04M1_10000	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K04M1_10020	COG4591	ABC-type transport system involved in lipoprotein release permease component
K04M1_10030	COG1136	(ABC) transporter
K04M1_10040	COG4591	ABC-type transport system involved in lipoprotein release permease component
K04M1_10060	COG0658	competence protein
K04M1_10060	COG2333	competence protein COMEC
K04M1_10070	COG1132	(ABC) transporter
K04M1_10110	COG2719	SpoVR family
K04M1_10120	COG2718	Belongs to the UPF0229 family
K04M1_10130	COG2766	serine protein kinase
K04M1_10140	COG3013	Belongs to the UPF0304 family
K04M1_10160	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K04M1_10180	COG1882	Formate acetyltransferase
K04M1_10230	COG4215	(ABC) transporter
K04M1_10260	COG0708	Exodeoxyribonuclease III
K04M1_10280	COG3923	Primosomal replication protein n
K04M1_10290	COG0730	response to heat
K04M1_10300	COG1199	ATP-dependent helicase activity
K04M1_10320	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K04M1_10330	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K04M1_10340	COG1187	pseudouridine synthase activity
K04M1_10360	COG1278	Cold shock
K04M1_10370	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K04M1_10380	COG0542	response to heat
K04M1_10390	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K04M1_10400	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K04M1_10410	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K04M1_10450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K04M1_10460	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K04M1_10470	COG0297	glycogen (starch) synthase activity
K04M1_10510	COG3070	regulator of competence-specific genes
K04M1_10520	COG1609	Transcriptional regulator
K04M1_10530	COG3381	protein complex oligomerization
K04M1_10540	COG0745	RESPONSE REGULATOR receiver
K04M1_10550	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K04M1_10560	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K04M1_10570	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
K04M1_10580	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
K04M1_10590	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K04M1_10630	COG0189	ligase activity
K04M1_10630	COG4067	protein conserved in archaea
K04M1_10640	COG0500	methyltransferase
K04M1_10660	COG1801	Protein of unknown function DUF72
K04M1_10680	COG0217	transcriptional regulatory protein
K04M1_10690	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K04M1_10700	COG0632	four-way junction helicase activity
K04M1_10710	COG2255	four-way junction helicase activity
K04M1_10720	COG1271	oxidase subunit
K04M1_10730	COG1294	oxidase, subunit
K04M1_10740	COG4890	Cyd operon protein YbgT
K04M1_10760	COG0824	Thioesterase
K04M1_10770	COG0811	peptide transport
K04M1_10800	COG0823	Involved in the tonB-independent uptake of proteins
K04M1_10810	COG2885	chlorophyll binding
K04M1_10820	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
K04M1_10830	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K04M1_10850	COG3766	membrane
K04M1_10870	COG0754	glutathionylspermidine amidase activity
K04M1_10890	COG5002	protein histidine kinase activity
K04M1_10890	COG0784	Response regulator, receiver
K04M1_10930	COG1294	oxidase, subunit
K04M1_10940	COG1271	oxidase subunit
K04M1_10990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K04M1_11000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K04M1_11050	COG3568	Endonuclease Exonuclease Phosphatase
K04M1_11100	COG0583	DNA-binding transcription factor activity
K04M1_11120	COG0686	Belongs to the AlaDH PNT family
K04M1_11140	COG1674	ftsk spoiiie
K04M1_11160	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K04M1_11200	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K04M1_11210	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K04M1_11250	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K04M1_11290	COG0300	oxidoreductase activity
K04M1_11320	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K04M1_11340	COG2268	Band 7 protein
K04M1_11360	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K04M1_11370	COG2915	High frequency lysogenization protein hflD homolog
K04M1_11400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K04M1_11420	COG1757	Na H antiporter
K04M1_11440	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K04M1_11460	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K04M1_11460	COG0131	Imidazoleglycerol-phosphate dehydratase
K04M1_11470	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K04M1_11480	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K04M1_11490	COG0107	imidazoleglycerol-phosphate synthase activity
K04M1_11500	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K04M1_11500	COG0140	phosphoribosyl-ATP diphosphatase activity
K04M1_11510	COG3012	SEC-C Motif Domain Protein
K04M1_11520	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K04M1_11530	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K04M1_11540	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K04M1_11550	COG0215	cysteine-tRNA ligase activity
K04M1_11560	COG1435	thymidine kinase activity
K04M1_11620	COG2116	formate transmembrane transporter activity
K04M1_11640	COG0390	transport system, permease component
K04M1_11650	COG4459	periplasmic nitrate reductase
K04M1_11660	COG3005	denitrification pathway
K04M1_11670	COG0243	molybdopterin cofactor binding
K04M1_11700	COG1227	inorganic diphosphatase activity
K04M1_11720	COG4172	Belongs to the ABC transporter superfamily
K04M1_11740	COG4171	peptide transport system, permease
K04M1_11750	COG4168	peptide transport system, permease
K04M1_11770	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K04M1_11780	COG1842	Phage shock protein A
K04M1_11800	COG1983	PspC domain protein
K04M1_11840	COG2818	Glycosylase
K04M1_11850	COG5380	lipid catabolic process
K04M1_11860	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
K04M1_11870	COG0626	cystathionine gamma-synthase activity
K04M1_11890	COG0733	neurotransmitter:sodium symporter activity
K04M1_11900	COG0564	pseudouridine synthase activity
K04M1_11920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K04M1_11930	COG1151	hydroxylamine reductase activity
K04M1_11940	COG3604	Transcriptional regulator
K04M1_11960	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K04M1_11970	COG4136	ATPase activity
K04M1_11980	COG4135	transport system, permease component
K04M1_11990	COG4134	Bacterial extracellular solute-binding protein
K04M1_12010	COG3313	Fe-S protein
K04M1_12050	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K04M1_12060	COG2205	protein histidine kinase activity
K04M1_12070	COG0745	RESPONSE REGULATOR receiver
K04M1_12090	COG1061	Type III restriction enzyme res subunit
K04M1_12100	COG1187	pseudouridine synthase activity
K04M1_12110	COG2814	Major facilitator Superfamily
K04M1_12130	COG0702	epimerase
K04M1_12140	COG0534	Mate efflux family protein
K04M1_12180	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K04M1_12200	COG1960	acyl-CoA dehydrogenase activity
K04M1_12210	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K04M1_12220	COG3273	potassium ion transport
K04M1_12220	COG2985	domain, Protein
K04M1_12230	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K04M1_12260	COG1737	Transcriptional regulator
K04M1_12270	COG0076	glutamate decarboxylase activity
K04M1_12290	COG2431	L-lysine efflux transmembrane transporter activity
K04M1_12310	COG3070	regulator of competence-specific genes
K04M1_12350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K04M1_12350	COG4191	Histidine kinase
K04M1_12370	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K04M1_12390	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K04M1_12400	COG4988	ABC transporter
K04M1_12410	COG0492	ferredoxin-NADP+ reductase activity
K04M1_12450	COG0745	RESPONSE REGULATOR receiver
K04M1_12450	COG3706	GGDEF domain
K04M1_12460	COG0471	metal ion transport
K04M1_12470	COG2949	membrane
K04M1_12480	COG0281	malic enzyme
K04M1_12490	COG1643	Atp-dependent helicase
K04M1_12520	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K04M1_12590	COG0277	FAD linked oxidase domain protein
K04M1_12590	COG0247	lactate metabolic process
K04M1_12620	COG2986	histidine ammonia-lyase
K04M1_12630	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K04M1_12640	COG0010	Belongs to the arginase family
K04M1_12650	COG1228	amidohydrolase
K04M1_12690	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K04M1_12710	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K04M1_12730	COG0393	Putative heavy-metal-binding
K04M1_12800	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K04M1_12810	COG0072	phenylalanine-tRNA ligase activity
K04M1_12810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K04M1_12830	COG0776	regulation of translation
K04M1_12850	COG0500	methyltransferase
K04M1_12860	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K04M1_12870	COG0295	cytidine deaminase activity
K04M1_12880	COG1346	cytolysis
K04M1_12890	COG1380	Effector of murein hydrolase LrgA
K04M1_12900	COG2925	Exonuclease
K04M1_13020	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K04M1_13080	COG1484	DNA-dependent DNA replication
K04M1_13380	COG0702	epimerase
K04M1_13390	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K04M1_13400	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K04M1_13440	COG2988	succinylglutamate desuccinylase activity
K04M1_13450	COG4139	cobalamin transport
K04M1_13460	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
K04M1_13500	COG0583	DNA-binding transcription factor activity
K04M1_13520	COG1451	nucleotide metabolic process
K04M1_13530	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
K04M1_13590	COG3938	Belongs to the proline racemase family
K04M1_13620	COG2423	ornithine cyclodeaminase activity
K04M1_13630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K04M1_13640	COG3842	ATPase activity
K04M1_13650	COG1176	ABC-type spermidine putrescine transport system, permease component I
K04M1_13660	COG1177	transmembrane transport
K04M1_13680	COG3291	Pkd domain containing protein
K04M1_13710	COG0444	Belongs to the ABC transporter superfamily
K04M1_13720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K04M1_13730	COG0601	transmembrane transport
K04M1_13750	COG2195	Cleaves the N-terminal amino acid of tripeptides
K04M1_13770	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K04M1_13790	COG0625	glutathione transferase activity
K04M1_13890	COG3755	Protein conserved in bacteria
K04M1_13940	COG1742	UPF0060 membrane protein
K04M1_13970	COG1757	Na H antiporter
K04M1_13980	COG0174	glutamine synthetase
K04M1_13990	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K04M1_14000	COG1396	sequence-specific DNA binding
K04M1_14000	COG1917	Cupin 2, conserved barrel domain protein
K04M1_14010	COG1012	belongs to the aldehyde dehydrogenase family
K04M1_14020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K04M1_14040	COG2957	Belongs to the agmatine deiminase family
K04M1_14050	COG1012	belongs to the aldehyde dehydrogenase family
K04M1_14060	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K04M1_14070	COG2200	EAL domain
K04M1_14090	COG1846	Transcriptional regulator
K04M1_14100	COG2315	Protein conserved in bacteria
K04M1_14180	COG3063	Type IV pilus biogenesis stability protein PilW
K04M1_14190	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K04M1_14220	COG1560	Kdo2-lipid A biosynthetic process
K04M1_14240	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K04M1_14490	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K04M1_14500	COG1280	lysine exporter protein (LysE YggA)
K04M1_14520	COG1115	amino acid carrier protein
K04M1_14570	COG1368	sulfuric ester hydrolase activity
K04M1_14580	COG2113	Glycine betaine
K04M1_14590	COG4176	ABC-type proline glycine betaine transport system permease component
K04M1_14600	COG4175	Glycine betaine
K04M1_14630	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K04M1_14640	COG0456	acetyltransferase
K04M1_14650	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K04M1_14660	COG0662	Cupin 2, conserved barrel domain protein
K04M1_14670	COG0527	aspartate kinase activity
K04M1_14680	COG3119	arylsulfatase activity
K04M1_14710	COG0641	radical SAM
K04M1_14740	COG3119	arylsulfatase activity
K04M1_14790	COG1538	Outer membrane efflux protein
K04M1_14820	COG1349	DNA-binding transcription factor activity
K04M1_14830	COG0673	inositol 2-dehydrogenase activity
K04M1_14840	COG4702	Belongs to the UPF0303 family
K04M1_14850	COG0745	RESPONSE REGULATOR receiver
K04M1_14850	COG3706	GGDEF domain
K04M1_14890	COG0471	metal ion transport
K04M1_14920	COG3300	MHYT domain
K04M1_14920	COG5001	Diguanylate cyclase
K04M1_14950	COG1328	CTP reductase activity
K04M1_14960	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K04M1_14980	COG0861	Integral membrane protein TerC family
K04M1_15000	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K04M1_15020	COG0814	amino acid
K04M1_15050	COG1120	ATPase activity
K04M1_15060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K04M1_15080	COG4774	siderophore transport
K04M1_15100	COG1132	(ABC) transporter
K04M1_15110	COG1132	(ABC) transporter
K04M1_15140	COG0583	DNA-binding transcription factor activity
K04M1_15190	COG0443	Heat shock 70 kDa protein
K04M1_15200	COG0443	Heat shock 70 kDa protein
K04M1_15300	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K04M1_15310	COG1643	Atp-dependent helicase
K04M1_15340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K04M1_15360	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K04M1_15370	COG1215	transferase activity, transferring glycosyl groups
K04M1_15380	COG0438	transferase activity, transferring glycosyl groups
K04M1_15440	COG0438	transferase activity, transferring glycosyl groups
K04M1_15450	COG0438	transferase activity, transferring glycosyl groups
K04M1_15460	COG2204	response regulator
K04M1_15530	COG1793	dna ligase
K04M1_15550	COG0534	Mate efflux family protein
K04M1_15560	COG0307	riboflavin synthase, alpha
K04M1_15600	COG3706	GGDEF domain
K04M1_15620	COG0791	NLP P60 protein
K04M1_15700	COG1940	carbohydrate kinase activity
K04M1_15730	COG0746	molybdenum cofactor guanylyltransferase activity
K04M1_15740	COG3842	ATPase activity
K04M1_15770	COG2204	response regulator
K04M1_15780	COG4191	Histidine kinase
K04M1_15790	COG0488	(ABC) transporter
K04M1_15810	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K04M1_15850	COG3381	protein complex oligomerization
K04M1_15870	COG0243	molybdopterin cofactor binding
K04M1_15870	COG3383	formate dehydrogenase (NAD+) activity
K04M1_15880	COG0437	4 iron, 4 sulfur cluster binding
K04M1_15930	COG0004	ammonium transporteR
K04M1_15950	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K04M1_15960	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K04M1_15970	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K04M1_15980	COG1177	transmembrane transport
K04M1_15990	COG1176	ABC-type spermidine putrescine transport system, permease component I
K04M1_16000	COG3842	ATPase activity
K04M1_16050	COG0589	response to stress
K04M1_16060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K04M1_16090	COG2217	Heavy metal translocating P-type atpase
K04M1_16110	COG2010	Cytochrome c
K04M1_16140	COG3278	Belongs to the heme-copper respiratory oxidase family
K04M1_16170	COG0784	Response regulator, receiver
K04M1_16170	COG2205	protein histidine kinase activity
K04M1_16200	COG3120	sequence-specific DNA binding
K04M1_16210	COG1067	ATP-dependent peptidase activity
K04M1_16220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K04M1_16270	COG0116	Belongs to the methyltransferase superfamily
K04M1_16270	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K04M1_16290	COG0167	dihydroorotate dehydrogenase activity
K04M1_16300	COG2902	Dehydrogenase
K04M1_16310	COG0308	aminopeptidase N
K04M1_16340	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
K04M1_16350	COG1956	GAF domain-containing protein
K04M1_16360	COG1132	(ABC) transporter
K04M1_16370	COG2995	paraquat-inducible protein a
K04M1_16380	COG3008	intermembrane lipid transfer
K04M1_16430	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K04M1_16440	COG1666	GTP binding
K04M1_16460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K04M1_16480	COG4597	amino acid ABC transporter
K04M1_16490	COG0765	amino acid transport
K04M1_16500	COG1126	abc transporter atp-binding protein
K04M1_16510	COG0670	Belongs to the BI1 family
K04M1_16530	COG2920	part of a sulfur-relay system
K04M1_16540	COG1254	Belongs to the acylphosphatase family
K04M1_16550	COG0840	transmembrane signaling receptor activity
K04M1_16590	COG2885	chlorophyll binding
K04M1_16640	COG2203	Gaf domain
K04M1_16640	COG2199	diguanylate cyclase activity
K04M1_16650	COG1414	Transcriptional regulator
K04M1_16670	COG0656	L-ascorbic acid biosynthetic process
K04M1_16680	COG0583	DNA-binding transcription factor activity
K04M1_16700	COG0583	DNA-binding transcription factor activity
K04M1_16710	COG2814	Major facilitator Superfamily
K04M1_16750	COG1335	isochorismatase
K04M1_16760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K04M1_16790	COG0646	methionine synthase
K04M1_16790	COG1410	methionine synthase
K04M1_16800	COG1126	abc transporter atp-binding protein
K04M1_16810	COG0765	amino acid transport
K04M1_16820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K04M1_16860	COG0583	DNA-binding transcription factor activity
K04M1_16890	COG0583	DNA-binding transcription factor activity
K04M1_16910	COG0583	DNA-binding transcription factor activity
K04M1_16940	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K04M1_16950	COG0602	queuosine metabolic process
K04M1_16960	COG0561	phosphatase activity
K04M1_17010	COG2828	Protein conserved in bacteria
K04M1_17030	COG0372	Belongs to the citrate synthase family
K04M1_17040	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K04M1_17110	COG0730	response to heat
K04M1_17150	COG0457	Tetratricopeptide repeat
K04M1_17280	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K04M1_17290	COG4790	Type iii secretion
K04M1_17300	COG4794	Type iii secretion
K04M1_17310	COG4791	protein targeting
K04M1_17320	COG4792	protein secretion
K04M1_17330	COG2207	Transcriptional regulator
K04M1_17390	COG3177	Filamentation induced by cAMP protein fic
K04M1_17430	COG4669	(LipO)protein
K04M1_17570	COG1012	belongs to the aldehyde dehydrogenase family
K04M1_17580	COG3284	Transcriptional regulator
K04M1_17610	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K04M1_17620	COG0363	glucosamine-6-phosphate deaminase activity
K04M1_17630	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K04M1_17640	COG2207	Transcriptional regulator
K04M1_17660	COG4565	transcriptional regulatory protein
K04M1_17670	COG3290	protein histidine kinase activity
K04M1_17700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K04M1_17760	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K04M1_17780	COG2985	domain, Protein
K04M1_17850	COG2272	Belongs to the type-B carboxylesterase lipase family
K04M1_17880	COG0729	surface antigen
K04M1_17900	COG1280	lysine exporter protein (LysE YggA)
K04M1_17910	COG1280	lysine exporter protein (LysE YggA)
K04M1_17920	COG5507	3-demethylubiquinone-9 3-methyltransferase
K04M1_17960	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K04M1_17980	COG0110	maltose O-acetyltransferase activity
K04M1_18060	COG2801	Transposase and inactivated derivatives
K04M1_18110	COG1683	Conserved Protein
K04M1_18230	COG2801	Transposase and inactivated derivatives
K04M1_18280	COG1403	HNH endonuclease
K04M1_18410	COG4974	Belongs to the 'phage' integrase family
K04M1_18440	COG3706	GGDEF domain
K04M1_18460	COG2985	domain, Protein
K04M1_18470	COG0076	glutamate decarboxylase activity
K04M1_18480	COG0598	Magnesium transport protein CorA
K04M1_18500	COG0387	Pfam Sodium calcium exchanger
K04M1_18510	COG0387	Pfam Sodium calcium exchanger
K04M1_18540	COG1289	transmembrane transporter activity
K04M1_18570	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K04M1_18590	COG2985	domain, Protein
K04M1_18600	COG0025	NhaP-type Na H and K H
K04M1_18620	COG2433	Pfam Transposase IS66
K04M1_18640	COG3302	dmso reductase anchor subunit
K04M1_18650	COG0437	4 iron, 4 sulfur cluster binding
K04M1_18660	COG0243	molybdopterin cofactor binding
K04M1_18680	COG2221	Nitrite and sulphite reductase 4Fe-4S
K04M1_18680	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K04M1_18690	COG0784	Response regulator, receiver
K04M1_18690	COG2205	protein histidine kinase activity
K04M1_18830	COG3477	response to acidic pH
K04M1_18840	COG2199	diguanylate cyclase activity
K04M1_18840	COG3287	FIST C domain
K04M1_18840	COG2200	EAL domain
K04M1_18850	COG2197	response regulator
K04M1_19000	COG1472	Belongs to the glycosyl hydrolase 3 family
K04M1_19020	COG2205	protein histidine kinase activity
K04M1_19020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K04M1_19030	COG2197	response regulator
K04M1_19160	COG1335	isochorismatase
K04M1_19290	COG4628	conserved protein (DUF2132)
K04M1_19350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K04M1_19370	COG3768	UPF0283 membrane protein
K04M1_19380	COG3106	COG3106 Predicted ATPase
K04M1_19410	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K04M1_19420	COG0784	Response regulator, receiver
K04M1_19420	COG2205	protein histidine kinase activity
K04M1_19440	COG0494	nUDIX hydrolase
K04M1_19450	COG0814	amino acid
K04M1_19460	COG1760	l-serine dehydratase
K04M1_19470	COG2200	EAL domain
K04M1_19490	COG0720	synthase
K04M1_19500	COG0840	transmembrane signaling receptor activity
K04M1_19510	COG0017	Asparaginyl-tRNA synthetase
K04M1_19530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K04M1_19560	COG1448	Aminotransferase
K04M1_19600	COG0840	transmembrane signaling receptor activity
K04M1_19610	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K04M1_19670	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K04M1_19700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K04M1_19710	COG3108	Peptidase M15
K04M1_19720	COG2989	Protein conserved in bacteria
K04M1_19770	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K04M1_19790	COG4235	cytochrome complex assembly
K04M1_19790	COG3088	subunit of a heme lyase
K04M1_19810	COG1138	Cytochrome C-type biogenesis protein
K04M1_19820	COG3301	Polysulphide reductase, NrfD
K04M1_19830	COG0437	4 iron, 4 sulfur cluster binding
K04M1_19850	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
K04M1_19890	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K04M1_19900	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K04M1_19910	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K04M1_19960	COG0019	diaminopimelate decarboxylase activity
K04M1_20040	COG0322	excinuclease ABC activity
K04M1_20050	COG2197	response regulator
K04M1_20060	COG0417	DNA replication proofreading
K04M1_20100	COG1187	pseudouridine synthase activity
K04M1_20120	COG0009	L-threonylcarbamoyladenylate synthase
K04M1_20130	COG0613	PHP domain protein
K04M1_20150	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K04M1_20160	COG0512	Glutamine amidotransferase of anthranilate synthase
K04M1_20180	COG0135	phosphoribosylanthranilate isomerase activity
K04M1_20180	COG0134	indole-3-glycerol-phosphate synthase activity
K04M1_20200	COG0159	tryptophan synthase activity
K04M1_20210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K04M1_20220	COG0318	PFAM AMP-dependent synthetase and ligase
K04M1_20230	COG1301	dicarboxylic acid transport
K04M1_20270	COG2917	probably involved in intracellular septation
K04M1_20280	COG1607	acyl-coa hydrolase
K04M1_20290	COG2350	Protein conserved in bacteria
K04M1_20310	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K04M1_20320	COG0583	DNA-binding transcription factor activity
K04M1_20350	COG5001	Diguanylate cyclase
K04M1_20360	COG1032	radical SAM domain protein
K04M1_20400	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K04M1_20410	COG0463	Glycosyl transferase, family 2
K04M1_20420	COG0745	RESPONSE REGULATOR receiver
K04M1_20430	COG3850	Histidine kinase
K04M1_20430	COG5002	protein histidine kinase activity
K04M1_20490	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K04M1_20530	COG1136	(ABC) transporter
K04M1_20530	COG0577	efflux transmembrane transporter activity
K04M1_20540	COG0577	efflux transmembrane transporter activity
K04M1_20540	COG1136	(ABC) transporter
K04M1_20550	COG1136	(ABC) transporter
K04M1_20550	COG0577	efflux transmembrane transporter activity
K04M1_20570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K04M1_20620	COG3118	belongs to the thioredoxin family
K04M1_20630	COG4232	protein-disulfide reductase activity
K04M1_20700	COG2863	cytochrome
K04M1_20710	COG3258	Cytochrome c
K04M1_20720	COG2995	paraquat-inducible protein a
K04M1_20730	COG3008	intermembrane lipid transfer
K04M1_20730	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K04M1_20770	COG4166	transmembrane transport
K04M1_20790	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K04M1_20800	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
K04M1_20820	COG0539	negative regulation of cytoplasmic translation
K04M1_20830	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K04M1_20840	COG0616	signal peptide processing
K04M1_20850	COG1028	Short-chain dehydrogenase reductase Sdr
K04M1_20880	COG0587	DNA-directed DNA polymerase activity
K04M1_20890	COG0784	Response regulator, receiver
K04M1_20890	COG0835	chemotaxis
K04M1_20900	COG1940	carbohydrate kinase activity
K04M1_20910	COG0469	pyruvate kinase activity
K04M1_20920	COG4667	esterase of the alpha-beta hydrolase superfamily
K04M1_20950	COG0733	neurotransmitter:sodium symporter activity
K04M1_20980	COG1263	PTS System
K04M1_20980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K04M1_20990	COG0084	hydrolase, TatD family'
K04M1_21000	COG0470	DNA polymerase III
K04M1_21010	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K04M1_21020	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K04M1_21080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K04M1_21090	COG0416	fatty acid biosynthetic process
K04M1_21110	COG1399	metal-binding, possibly nucleic acid-binding protein
K04M1_21120	COG0424	maF-like protein
K04M1_21130	COG0564	pseudouridine synthase activity
K04M1_21140	COG1530	ribonuclease E activity
K04M1_21150	COG0659	secondary active sulfate transmembrane transporter activity
K04M1_21160	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K04M1_21170	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
K04M1_21190	COG0572	uridine kinase
K04M1_21210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K04M1_21210	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K04M1_21250	COG2186	Transcriptional regulator
K04M1_21260	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K04M1_21270	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K04M1_21280	COG3318	Belongs to the UPF0149 family
K04M1_21280	COG3012	SEC-C Motif Domain Protein
K04M1_21290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K04M1_21300	COG3706	GGDEF domain
K04M1_21310	COG0366	Alpha amylase catalytic
K04M1_21320	COG1122	ATPase activity
K04M1_21330	COG4120	Belongs to the binding-protein-dependent transport system permease family
K04M1_21350	COG3092	negative regulation of chromosome organization
K04M1_21360	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K04M1_21370	COG0280	phosphate acetyltransferase
K04M1_21370	COG0857	belongs to the CobB CobQ family
K04M1_21390	COG0435	Glutathione S-transferase
K04M1_21410	COG0444	Belongs to the ABC transporter superfamily
K04M1_21420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K04M1_21430	COG0601	transmembrane transport
K04M1_21450	COG0314	molybdopterin synthase activity
K04M1_21460	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K04M1_21470	COG0315	cyclic pyranopterin monophosphate synthase activity
K04M1_21480	COG0521	Mo-molybdopterin cofactor biosynthetic process
K04M1_21490	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K04M1_21500	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K04M1_21510	COG2198	Histidine kinase
K04M1_21520	COG2204	response regulator
K04M1_21530	COG0556	nucleotide-excision repair
K04M1_21550	COG1882	Formate acetyltransferase
K04M1_21560	COG4657	Part of a membrane complex involved in electron transport
K04M1_21570	COG2878	Part of a membrane complex involved in electron transport
K04M1_21580	COG4656	Part of a membrane complex involved in electron transport
K04M1_21590	COG4658	electron transport chain
K04M1_21600	COG4659	FMN binding
K04M1_21610	COG4660	Part of a membrane complex involved in electron transport
K04M1_21620	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K04M1_21630	COG0346	lactoylglutathione lyase activity
K04M1_21650	COG2885	chlorophyll binding
K04M1_21660	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K04M1_21670	COG2056	Na+-H+ antiporter family
K04M1_21710	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K04M1_21750	COG1454	alcohol dehydrogenase
K04M1_21750	COG1012	belongs to the aldehyde dehydrogenase family
K04M1_21760	COG2095	MarC family integral membrane protein
K04M1_21770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K04M1_21780	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K04M1_21790	COG1757	Na H antiporter
K04M1_21820	COG3081	Nucleoid-associated protein
K04M1_21830	COG3082	Protein of unknown function (DUF1414)
K04M1_21840	COG3083	sulfuric ester hydrolase activity
K04M1_21860	COG0123	including yeast histone deacetylase and acetoin utilization protein
K04M1_21890	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K04M1_21900	COG0778	Nitroreductase
K04M1_21920	COG0446	pyridine nucleotide-disulphide oxidoreductase
K04M1_21920	COG1902	pentaerythritol trinitrate reductase activity
K04M1_21930	COG0616	signal peptide processing
K04M1_21940	COG0252	asparaginase activity
K04M1_21950	COG3139	Protein of unknown function (DUF1315)
K04M1_21970	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K04M1_21980	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K04M1_22010	COG2226	methyltransferase
K04M1_22040	COG1785	Belongs to the alkaline phosphatase family
K04M1_22060	COG0346	lactoylglutathione lyase activity
K04M1_22070	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
K04M1_22080	COG0668	transmembrane transport
K04M1_22090	COG2983	Belongs to the UPF0260 family
K04M1_22100	COG2261	transglycosylase associated protein
K04M1_22120	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K04M1_22130	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K04M1_22140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K04M1_22160	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K04M1_22170	COG2832	Protein of unknown function (DUF454)
K04M1_22190	COG0745	RESPONSE REGULATOR receiver
K04M1_22200	COG0583	DNA-binding transcription factor activity
K04M1_22210	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K04M1_22220	COG1286	toxin biosynthetic process
K04M1_22230	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
K04M1_22240	COG0285	dihydrofolate synthase activity
K04M1_22250	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K04M1_22260	COG0101	tRNA pseudouridine synthase activity
K04M1_22280	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K04M1_22290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K04M1_22300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K04M1_22310	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K04M1_22310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K04M1_22320	COG0431	NADPH-dependent FMN reductase
K04M1_22340	COG3101	peptidyl-lysine hydroxylation
K04M1_22350	COG2860	membrane
K04M1_22360	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K04M1_22370	COG2890	protein-(glutamine-N5) methyltransferase activity
K04M1_22380	COG2840	Smr protein MutS2
K04M1_22390	COG2062	phosphohistidine phosphatase, SixA
K04M1_22420	COG1250	3-hydroxyacyl-CoA dehydrogenase
K04M1_22420	COG1024	Enoyl-CoA hydratase
K04M1_22430	COG0183	Belongs to the thiolase family
K04M1_22480	COG2067	long-chain fatty acid transport protein
K04M1_22520	COG3088	subunit of a heme lyase
K04M1_22520	COG4235	cytochrome complex assembly
K04M1_22540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K04M1_22550	COG1138	Cytochrome C-type biogenesis protein
K04M1_22560	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K04M1_22570	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K04M1_22580	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K04M1_22590	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K04M1_22600	COG4133	protoheme IX ABC transporter activity
K04M1_22620	COG0835	chemotaxis
K04M1_22640	COG1192	Involved in chromosome partitioning
K04M1_22650	COG2201	protein-glutamate methylesterase activity
K04M1_22660	COG0643	Histidine kinase
K04M1_22660	COG2198	Histidine kinase
K04M1_22670	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
K04M1_22700	COG0455	bacterial-type flagellum organization
K04M1_22750	COG1987	bacterial-type flagellum assembly
K04M1_22860	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K04M1_22880	COG1677	Flagellar hook-basal body complex protein FliE
K04M1_22890	COG2204	response regulator
K04M1_22900	COG4191	Histidine kinase
K04M1_22910	COG2204	response regulator
K04M1_22920	COG1516	flagellar protein fliS
K04M1_22940	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K04M1_22950	COG1334	flagellar protein FlaG
K04M1_22960	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K04M1_22970	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K04M1_22980	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K04M1_22990	COG2837	iron assimilation
K04M1_23040	COG1393	Belongs to the ArsC family
K04M1_23050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K04M1_23090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K04M1_23110	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K04M1_23160	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K04M1_23180	COG1053	succinate dehydrogenase
K04M1_23310	COG0210	DNA helicase
K04M1_23380	COG1278	Cold shock
K04M1_23430	COG1278	Cold shock
K04M1_23440	COG4974	Belongs to the 'phage' integrase family
K04M1_23450	COG0330	HflC and HflK could
K04M1_23490	COG1278	Cold shock
K04M1_23520	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K04M1_23550	COG4783	chaperone-mediated protein folding
K04M1_23560	COG1393	Belongs to the ArsC family
K04M1_23600	COG2233	PERMEase
K04M1_23610	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K04M1_23620	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K04M1_23630	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K04M1_23650	COG0121	glutamine amidotransferase
K04M1_23660	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K04M1_23670	COG1960	acyl-CoA dehydrogenase activity
K04M1_23730	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K04M1_23740	COG0328	RNA-DNA hybrid ribonuclease activity
K04M1_23750	COG2226	methyltransferase
K04M1_23760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K04M1_23770	COG0741	lytic transglycosylase activity
K04M1_23770	COG1388	LysM domain
K04M1_23790	COG3021	interspecies interaction between organisms
K04M1_23800	COG0347	Belongs to the P(II) protein family
K04M1_23830	COG0825	malonyl-CoA metabolic process
K04M1_23840	COG0587	DNA-directed DNA polymerase activity
K04M1_23860	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K04M1_23870	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K04M1_23890	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K04M1_23900	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
K04M1_23920	COG0750	zinc metalloprotease
K04M1_23930	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K04M1_23940	COG0575	Belongs to the CDS family
K04M1_23950	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K04M1_23960	COG0233	cytoplasmic translational termination
K04M1_23970	COG0528	UMP kinase activity
K04M1_23980	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K04M1_23990	COG0052	Belongs to the universal ribosomal protein uS2 family
K04M1_24000	COG0024	Methionine aminopeptidase
K04M1_24010	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K04M1_24030	COG0564	pseudouridine synthase activity
K04M1_24040	COG3098	single-species biofilm formation
K04M1_24100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K04M1_24110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K04M1_24160	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K04M1_24170	COG0254	rRNA binding
K04M1_24180	COG1720	tRNA m6t6A37 methyltransferase activity
K04M1_24190	COG0442	prolyl-tRNA aminoacylation
K04M1_24230	COG0733	neurotransmitter:sodium symporter activity
K04M1_24260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K04M1_24270	COG0514	ATP-dependent DNA helicase (RecQ)
K04M1_24320	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K04M1_24480	COG0659	secondary active sulfate transmembrane transporter activity
K04M1_24490	COG0589	response to stress
K04M1_24500	COG0519	Catalyzes the synthesis of GMP from XMP
K04M1_24600	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K04M1_24620	COG0745	RESPONSE REGULATOR receiver
K04M1_24620	COG3706	GGDEF domain
K04M1_24640	COG1477	protein flavinylation
K04M1_24650	COG2871	sodium ion transport
K04M1_24660	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K04M1_24670	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K04M1_24680	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K04M1_24690	COG1805	sodium ion transport
K04M1_24700	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K04M1_24710	COG0271	Belongs to the BolA IbaG family
K04M1_24720	COG2813	Specifically methylates the guanine in position
K04M1_24730	COG3056	Lipoprotein
K04M1_24770	COG1595	DNA-templated transcription, initiation
K04M1_24810	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K04M1_24820	COG0693	protein deglycase activity
K04M1_24830	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K04M1_24840	COG3706	GGDEF domain
K04M1_24850	COG2166	iron-sulfur cluster assembly
K04M1_24860	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K04M1_24870	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
K04M1_24890	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K04M1_24890	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K04M1_24910	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K04M1_24920	COG1074	ATP-dependent DNA helicase activity
K04M1_24930	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K04M1_25030	COG0270	DNA (cytosine-5-)-methyltransferase activity
K04M1_25080	COG3141	response to X-ray
K04M1_25110	COG2171	N-acyltransferase activity
K04M1_25120	COG0584	glycerophosphoryl diester phosphodiesterase
K04M1_25130	COG2271	Major facilitator Superfamily
K04M1_25140	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K04M1_25150	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K04M1_25160	COG1349	DNA-binding transcription factor activity
K04M1_25170	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K04M1_25180	COG0598	Magnesium transport protein CorA
K04M1_25220	COG1609	Transcriptional regulator
K04M1_25230	COG0583	DNA-binding transcription factor activity
K04M1_25310	COG1022	Amp-dependent synthetase and ligase
K04M1_25330	COG0583	DNA-binding transcription factor activity
K04M1_25340	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K04M1_25350	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K04M1_25370	COG0560	Phosphoserine phosphatase
K04M1_25390	COG0813	purine-nucleoside phosphorylase activity
K04M1_25400	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K04M1_25410	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K04M1_25420	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K04M1_25430	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K04M1_25440	COG0084	hydrolase, TatD family'
K04M1_25500	COG3153	acetyltransferase
K04M1_25550	COG0534	Mate efflux family protein
K04M1_25580	COG1185	polyribonucleotide nucleotidyltransferase activity
K04M1_25590	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K04M1_25600	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K04M1_25610	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K04M1_25620	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K04M1_25630	COG0195	Participates in both transcription termination and antitermination
K04M1_25640	COG0779	Required for maturation of 30S ribosomal subunits
K04M1_25670	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K04M1_25680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K04M1_25690	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K04M1_25700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K04M1_25710	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K04M1_25720	COG1534	Rna-binding protein
K04M1_25730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K04M1_25740	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K04M1_25750	COG2027	D-alanyl-D-alanine carboxypeptidase
K04M1_25770	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K04M1_25780	COG0739	heme binding
K04M1_25830	COG0628	permease
K04M1_25860	COG0747	negative chemotaxis
K04M1_25880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K04M1_25890	COG0444	Belongs to the ABC transporter superfamily
K04M1_25900	COG4608	Belongs to the ABC transporter superfamily
K04M1_25920	COG2971	BadF BadG BcrA BcrD
K04M1_25950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K04M1_25960	COG3842	ATPase activity
K04M1_25980	COG1840	ABC-type Fe3 transport system, periplasmic component
K04M1_25990	COG0004	ammonium transporteR
K04M1_26010	COG3112	Uncharacterised protein family (UPF0231)
K04M1_26020	COG1049	propionate catabolic process, 2-methylcitrate cycle
K04M1_26030	COG1752	Esterase of the alpha-beta hydrolase superfamily
K04M1_26040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K04M1_26050	COG1643	Atp-dependent helicase
K04M1_26060	COG1489	DNA binding
K04M1_26070	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K04M1_26080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K04M1_26100	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K04M1_26110	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K04M1_26120	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K04M1_26130	COG1560	Kdo2-lipid A biosynthetic process
K04M1_26140	COG0842	Transport permease protein
K04M1_26150	COG1131	(ABC) transporter
K04M1_26160	COG0659	secondary active sulfate transmembrane transporter activity
K04M1_26170	COG0288	reversible hydration of carbon dioxide
K04M1_26200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K04M1_26210	COG0508	dehydrogenase complex catalyzes the overall conversion of
K04M1_26220	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K04M1_26230	COG2186	Transcriptional regulator
K04M1_26250	COG0157	Belongs to the NadC ModD family
K04M1_26260	COG4969	Belongs to the N-Me-Phe pilin family
K04M1_26270	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K04M1_26280	COG1459	type II secretion system
K04M1_26300	COG0237	dephospho-CoA kinase activity
K04M1_26310	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
K04M1_26320	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K04M1_26350	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K04M1_26360	COG0228	four-way junction DNA binding
K04M1_26370	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K04M1_26380	COG4137	Cytochrome C assembly protein
K04M1_26390	COG4536	flavin adenine dinucleotide binding
K04M1_26400	COG1854	S-ribosylhomocysteine lyase activity
K04M1_26430	COG0612	Peptidase, M16
K04M1_26440	COG1238	metal cluster binding
K04M1_26460	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K04M1_26470	COG0511	ligase activity, forming carbon-carbon bonds
K04M1_26470	COG5016	pyruvate
K04M1_26600	COG0527	aspartate kinase activity
K04M1_26610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K04M1_26620	COG2137	regulation of response to DNA damage stimulus
K04M1_26630	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K04M1_26640	COG1546	Belongs to the CinA family
K04M1_26650	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K04M1_26660	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K04M1_26680	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K04M1_26690	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K04M1_26710	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K04M1_26720	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K04M1_26730	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K04M1_26740	COG0148	phosphopyruvate hydratase activity
K04M1_26750	COG0504	CTP synthase activity
K04M1_26760	COG3956	TIGRFAM MazG family protein
K04M1_26780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K04M1_26790	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K04M1_26810	COG0736	holo-[acyl-carrier-protein] synthase activity
K04M1_26820	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K04M1_26830	COG1381	Involved in DNA repair and RecF pathway recombination
K04M1_26840	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K04M1_26860	COG0681	Belongs to the peptidase S26 family
K04M1_26870	COG0481	GTPase activity
K04M1_26880	COG3086	response to oxidative stress
K04M1_26910	COG1595	DNA-templated transcription, initiation
K04M1_26920	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K04M1_26940	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K04M1_26980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K04M1_26990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K04M1_27000	COG3079	Belongs to the UPF0149 family
K04M1_27010	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K04M1_27020	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K04M1_27030	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K04M1_27040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K04M1_27060	COG0583	DNA-binding transcription factor activity
K04M1_27090	COG0668	transmembrane transport
K04M1_27100	COG0191	fructose-bisphosphate aldolase activity
K04M1_27130	COG4771	TonB-dependent receptor
K04M1_27140	COG0583	DNA-binding transcription factor activity
K04M1_27150	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K04M1_27160	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K04M1_27180	COG3091	SprT-like family
K04M1_27190	COG2356	endonuclease I
K04M1_27200	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K04M1_27210	COG0189	ligase activity
K04M1_27220	COG1678	Uncharacterized ACR, COG1678
K04M1_27230	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K04M1_27260	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K04M1_27270	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K04M1_27280	COG0762	integral membrane protein
K04M1_27290	COG1872	DUF167
K04M1_27310	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K04M1_27320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K04M1_27330	COG2066	Belongs to the glutaminase family
K04M1_27350	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K04M1_27370	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
K04M1_27460	COG0840	transmembrane signaling receptor activity
K04M1_27610	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K04M1_27630	COG3394	polysaccharide catabolic process
K04M1_27640	COG1486	melibiose metabolic process
K04M1_27650	COG1447	Phosphotransferase system cellobiose-specific component IIA
K04M1_27660	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K04M1_27680	COG0726	polysaccharide deacetylase
K04M1_27700	COG1028	Short-chain dehydrogenase reductase Sdr
K04M1_27710	COG4325	translation initiation factor activity
K04M1_27730	COG0795	lipopolysaccharide-transporting ATPase activity
K04M1_27740	COG0795	lipopolysaccharide-transporting ATPase activity
K04M1_27750	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K04M1_27760	COG2927	DNA polymerase III (CHI subunit)
K04M1_27770	COG0525	valine-tRNA ligase activity
K04M1_27790	COG0456	acetyltransferase
K04M1_27850	COG0540	Belongs to the ATCase OTCase family
K04M1_27860	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K04M1_27870	COG0251	oxidation-reduction process
K04M1_27880	COG0204	Acyl-transferase
K04M1_27890	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K04M1_27900	COG5007	Belongs to the BolA IbaG family
K04M1_27920	COG2854	intermembrane phospholipid transfer
K04M1_27930	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K04M1_27940	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K04M1_27950	COG1127	ABC transporter
K04M1_27970	COG0517	IMP dehydrogenase activity
K04M1_27970	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K04M1_27990	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K04M1_28000	COG1137	ATPase activity
K04M1_28020	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K04M1_28030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K04M1_28040	COG1660	Displays ATPase and GTPase activities
K04M1_28050	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K04M1_28060	COG2239	Acts as a magnesium transporter
K04M1_28070	COG0312	modulator of DNA gyrase
K04M1_28080	COG3028	Belongs to the UPF0307 family
K04M1_28090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K04M1_28100	COG0564	pseudouridine synthase activity
K04M1_28120	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K04M1_28130	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K04M1_28140	COG0312	modulator of DNA gyrase
K04M1_28150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K04M1_28160	COG3164	Protein of unknown function
K04M1_28170	COG1530	ribonuclease E activity
K04M1_28180	COG0424	maF-like protein
K04M1_28190	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K04M1_28200	COG1792	Involved in formation and maintenance of cell shape
K04M1_28210	COG1077	Cell shape determining protein MreB Mrl
K04M1_28300	COG1459	type II secretion system
K04M1_28310	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K04M1_28330	COG3409	Peptidoglycan-binding domain 1 protein
K04M1_28330	COG3267	Type II secretory pathway component ExeA
K04M1_28340	COG1450	Type ii and iii secretion system protein
K04M1_28380	COG2199	diguanylate cyclase activity
K04M1_28380	COG2200	EAL domain
K04M1_28390	COG0629	single-stranded DNA binding
K04M1_28420	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K04M1_28460	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K04M1_28470	COG0527	aspartate kinase activity
K04M1_28480	COG0646	methionine synthase
K04M1_28480	COG1410	methionine synthase
K04M1_28610	COG0175	sulfate reduction
K04M1_28620	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K04M1_28630	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K04M1_28670	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K04M1_28680	COG0735	belongs to the Fur family
K04M1_28700	COG0166	Belongs to the GPI family
K04M1_28710	COG0432	Pfam Uncharacterised protein family UPF0047
K04M1_28720	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K04M1_28730	COG0305	Participates in initiation and elongation during chromosome replication
K04M1_28770	COG2965	DNA replication, synthesis of RNA primer
K04M1_28780	COG0360	Binds together with S18 to 16S ribosomal RNA
K04M1_28790	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K04M1_28800	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K04M1_28820	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K04M1_28830	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K04M1_28890	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K04M1_28910	COG0678	peroxiredoxin activity
K04M1_28910	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K04M1_28920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K04M1_28950	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K04M1_28950	COG0165	Argininosuccinate lyase
K04M1_28960	COG0137	argininosuccinate synthase activity
K04M1_28980	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K04M1_29000	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K04M1_29020	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K04M1_29030	COG0460	homoserine dehydrogenase
K04M1_29030	COG0527	aspartate kinase activity
K04M1_29040	COG0626	cystathionine gamma-synthase activity
K04M1_29060	COG0281	malic enzyme
K04M1_29080	COG2906	2 iron, 2 sulfur cluster binding
K04M1_29090	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K04M1_29100	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K04M1_29140	COG2923	Belongs to the DsrF TusC family
K04M1_29150	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
K04M1_29160	COG2964	Protein conserved in bacteria
K04M1_29170	COG0545	Peptidyl-prolyl cis-trans isomerase
K04M1_29200	COG1446	asparaginase
K04M1_29210	COG1047	Peptidyl-prolyl cis-trans
K04M1_29240	COG2249	NAD(P)H dehydrogenase (quinone) activity
K04M1_29250	COG0488	(ABC) transporter
K04M1_29270	COG0429	hydrolase of the alpha beta-hydrolase fold
K04M1_29290	COG3954	Phosphoribulokinase
K04M1_29300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K04M1_29340	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K04M1_29350	COG0512	Glutamine amidotransferase of anthranilate synthase
K04M1_29380	COG0180	Tryptophanyl-tRNA synthetase
K04M1_29390	COG0546	phosphoglycolate phosphatase activity
K04M1_29400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K04M1_29410	COG0557	exoribonuclease II activity
K04M1_29420	COG1959	2 iron, 2 sulfur cluster binding
K04M1_29430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K04M1_29430	COG1017	nitric oxide dioxygenase activity
K04M1_29440	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
K04M1_29450	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K04M1_29460	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
K04M1_29470	COG0330	HflC and HflK could
K04M1_29480	COG0330	HflC and HflK could
K04M1_29490	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K04M1_29510	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K04M1_29520	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K04M1_29540	COG0802	atpase or kinase
K04M1_29560	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K04M1_29690	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K04M1_29700	COG1162	GTPase activity
K04M1_29710	COG0688	phosphatidylethanolamine metabolic process
K04M1_29720	COG0471	metal ion transport
K04M1_29740	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K04M1_29750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K04M1_29760	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K04M1_29770	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K04M1_29780	COG1045	serine acetyltransferase
K04M1_29790	COG4942	peptidase
K04M1_29830	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K04M1_29840	COG1053	succinate dehydrogenase
K04M1_29850	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K04M1_29860	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K04M1_29870	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K04M1_29900	COG1509	lysine 2,3-aminomutase activity
K04M1_29910	COG1285	pathogenesis
K04M1_29930	COG0459	protein refolding
K04M1_29940	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K04M1_29950	COG0534	Mate efflux family protein
K04M1_29960	COG0205	6-phosphofructokinase activity
K04M1_29970	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K04M1_29980	COG3678	ATP-independent chaperone mediated protein folding
K04M1_29990	COG0745	RESPONSE REGULATOR receiver
K04M1_30000	COG2205	protein histidine kinase activity
K04M1_30020	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K04M1_30030	COG3030	protein affecting phage T7 exclusion by the F plasmid
K04M1_30040	COG1027	Aspartate ammonia-lyase
K04M1_30050	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K04M1_30060	COG4232	protein-disulfide reductase activity
K04M1_30080	COG3263	regulation of cellular component size
K04M1_30100	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K04M1_30150	COG2814	Major facilitator Superfamily
K04M1_30180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K04M1_30190	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K04M1_30200	COG0511	ligase activity, forming carbon-carbon bonds
K04M1_30210	COG0439	Biotin carboxylase
K04M1_30220	COG2264	protein methyltransferase activity
K04M1_30230	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K04M1_30240	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K04M1_30260	COG0488	(ABC) transporter
K04M1_30360	COG1982	Orn Lys Arg decarboxylase major
K04M1_30370	COG0531	amino acid
K04M1_30380	COG3710	Transcriptional regulator
K04M1_30390	COG0789	Transcriptional regulator
K04M1_30410	COG0151	Belongs to the GarS family
K04M1_30440	COG1253	flavin adenine dinucleotide binding
K04M1_30450	COG3068	Protein conserved in bacteria
K04M1_30470	COG1573	uracil-dna glycosylase
K04M1_30480	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K04M1_30490	COG2816	NAD+ diphosphatase activity
K04M1_30500	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
K04M1_30510	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K04M1_30520	COG0085	RNA polymerase activity
K04M1_30530	COG0222	ribosome binding
K04M1_30540	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K04M1_30570	COG0250	Participates in transcription elongation, termination and antitermination
K04M1_30580	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K04M1_30590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K04M1_30650	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K04M1_30650	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K04M1_30660	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K04M1_30680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K04M1_30850	COG4206	TonB-dependent receptor
K04M1_30890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K04M1_30900	COG0534	Mate efflux family protein
K04M1_30910	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K04M1_30920	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K04M1_30930	COG2937	Belongs to the GPAT DAPAT family
K04M1_30940	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K04M1_30950	COG3161	chorismate lyase activity
K04M1_30960	COG1580	Controls the rotational direction of flagella during chemotaxis
K04M1_30970	COG0705	Rhomboid family
K04M1_30980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K04M1_31000	COG2177	Part of the ABC transporter FtsEX involved in
K04M1_31010	COG2884	Cell division ATP-binding protein ftsE
K04M1_31020	COG0552	protein localization to endoplasmic reticulum
K04M1_31030	COG0742	ribosomal rna small subunit methyltransferase
K04M1_31050	COG2095	MarC family integral membrane protein
K04M1_31130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K04M1_31140	COG0640	Transcriptional regulator
K04M1_31150	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K04M1_31160	COG1280	lysine exporter protein (LysE YggA)
K04M1_31170	COG2267	carboxylic ester hydrolase activity
K04M1_31180	COG0561	phosphatase activity
K04M1_31220	COG3287	FIST C domain
K04M1_31220	COG2200	EAL domain
K04M1_31220	COG2199	diguanylate cyclase activity
K04M1_31230	COG1011	Hydrolase
K04M1_31240	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K04M1_31270	COG0019	diaminopimelate decarboxylase activity
K04M1_31280	COG1965	Belongs to the frataxin family
K04M1_31290	COG3072	Adenylate cyclase
K04M1_31300	COG0181	hydroxymethylbilane synthase activity
K04M1_31310	COG1587	Uroporphyrinogen-III synthase
K04M1_31320	COG2959	enzyme of heme biosynthesis
K04M1_31330	COG3071	HemY protein
K04M1_31420	COG0633	Ferredoxin
K04M1_31430	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K04M1_31450	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K04M1_31460	COG3118	belongs to the thioredoxin family
K04M1_31470	COG0513	Belongs to the DEAD box helicase family
K04M1_31480	COG0248	Ppx GppA phosphatase
K04M1_31500	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K04M1_31520	COG0514	ATP-dependent DNA helicase (RecQ)
K04M1_31530	COG2962	Rard protein
K04M1_31550	COG1280	lysine exporter protein (LysE YggA)
K04M1_31560	COG0405	Gamma-glutamyltransferase
K04M1_31570	COG0210	DNA helicase
K04M1_31590	COG3220	belongs to the UPF0276 family
K04M1_31650	COG0006	proline dipeptidase activity
K04M1_31650	COG0006	proline dipeptidase activity
K04M1_31680	COG2104	thiamine diphosphate biosynthetic process
K04M1_31690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K04M1_31730	COG2132	Multicopper oxidase
K04M1_31830	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K04M1_31870	COG0009	L-threonylcarbamoyladenylate synthase
K04M1_31880	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K04M1_31890	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K04M1_31900	COG0551	DNA topoisomerase type I activity
K04M1_31910	COG2922	Belongs to the Smg family
K04M1_31920	COG0758	DNA mediated transformation
K04M1_31940	COG0242	peptide deformylase activity
K04M1_31950	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K04M1_31960	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K04M1_31960	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K04M1_31970	COG0569	domain protein
K04M1_31980	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K04M1_32000	COG1272	protein, Hemolysin III
K04M1_32010	COG4326	sporulation control protein
K04M1_32030	COG3084	Protein conserved in bacteria
K04M1_32050	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K04M1_32060	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K04M1_32070	COG0204	Acyl-transferase
K04M1_32090	COG0606	chelatase, subunit chli
K04M1_32110	COG3978	acetolactate synthase activity
K04M1_32120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K04M1_32130	COG0129	dihydroxy-acid dehydratase activity
K04M1_32150	COG0583	DNA-binding transcription factor activity
K04M1_32160	COG2814	Major facilitator Superfamily
K04M1_32180	COG0765	amino acid transport
K04M1_32210	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K04M1_32220	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K04M1_32230	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K04M1_32240	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K04M1_32250	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K04M1_32260	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K04M1_32280	COG0356	it plays a direct role in the translocation of protons across the membrane
K04M1_32290	COG3312	ion transport
K04M1_32300	COG1475	DNA binding
K04M1_32310	COG1192	Involved in chromosome partitioning
K04M1_32320	COG0357	Ribosomal RNA small subunit methyltransferase G
K04M1_32330	COG0445	tRNA wobble uridine modification
K04M1_32340	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K04M1_32360	COG0706	membrane insertase activity
K04M1_32370	COG0594	ribonuclease P activity
K04M1_32390	COG1126	abc transporter atp-binding protein
K04M1_32440	COG1444	tRNA N-acetyltransferase activity
K04M1_32480	COG3340	Belongs to the peptidase S51 family
K04M1_32490	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K04M1_32500	COG1263	PTS System
K04M1_32500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K04M1_32510	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K04M1_32540	COG4166	transmembrane transport
K04M1_32640	COG0259	pyridoxamine-phosphate oxidase activity
K04M1_32690	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K04M1_32770	COG1132	(ABC) transporter
K04M1_32790	COG0513	Belongs to the DEAD box helicase family
K04M1_32800	COG2258	MOSC domain
K04M1_32890	COG3634	alkyl hydroperoxide reductase activity
K04M1_32900	COG0450	alkyl hydroperoxide reductase
K04M1_32980	COG1846	Transcriptional regulator
K04M1_32990	COG1764	response to oxidative stress
K04M1_33070	COG1136	(ABC) transporter
K04M1_33120	COG0745	RESPONSE REGULATOR receiver
K04M1_33140	COG1653	transport
K04M1_33150	COG0019	diaminopimelate decarboxylase activity
K04M1_33160	COG4264	IucA IucC family
K04M1_33210	COG4772	TonB-dependent receptor
K04M1_33220	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K04M1_33230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K04M1_33240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K04M1_33250	COG1120	ATPase activity
K04M1_33260	COG0840	transmembrane signaling receptor activity
K04M1_33270	COG0612	Peptidase, M16
K04M1_33290	COG0739	heme binding
K04M1_33320	COG2814	Major facilitator Superfamily
K04M1_33340	COG1609	Transcriptional regulator
K04M1_33350	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K04M1_33400	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K04M1_33410	COG1609	Transcriptional regulator
K04M1_33460	COG0596	Alpha beta hydrolase
K04M1_33510	COG1760	l-serine dehydratase
K04M1_33530	COG4580	involved in the transport of maltose and maltodextrins
K04M1_33570	COG2356	endonuclease I
K04M1_33610	COG1982	Orn Lys Arg decarboxylase major
K04M1_33620	COG0531	amino acid
K04M1_33640	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K04M1_33650	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
K04M1_33660	COG1162	GTPase activity
K04M1_33670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K04M1_33670	COG1263	PTS System
K04M1_33680	COG1999	signal sequence binding
K04M1_33710	COG2909	trisaccharide binding
K04M1_33720	COG0058	SHG alpha-glucan phosphorylase activity
K04M1_33730	COG1640	4-alpha-glucanotransferase
K04M1_33740	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K04M1_33750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K04M1_33760	COG0366	Alpha amylase catalytic
K04M1_33780	COG3366	ferrous iron transmembrane transporter activity
K04M1_33790	COG0700	Nucleoside recognition
K04M1_33800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K04M1_33810	COG3339	Conserved Protein
K04M1_33820	COG1301	dicarboxylic acid transport
K04M1_33840	COG0583	DNA-binding transcription factor activity
K04M1_33890	COG1596	polysaccharide export
K04M1_33920	COG2095	MarC family integral membrane protein
K04M1_33930	COG4667	esterase of the alpha-beta hydrolase superfamily
K04M1_33940	COG3397	chitin binding
K04M1_33950	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K04M1_33960	COG0415	Belongs to the DNA photolyase family
K04M1_34000	COG1686	Belongs to the peptidase S11 family
K04M1_34050	COG0583	DNA-binding transcription factor activity
K04M1_34060	COG4628	conserved protein (DUF2132)
K04M1_34110	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K04M1_34120	COG0628	permease
K04M1_34170	COG1289	transmembrane transporter activity
K04M1_34200	COG2814	Major facilitator Superfamily
K04M1_34220	COG0454	-acetyltransferase
K04M1_34240	COG0745	RESPONSE REGULATOR receiver
K04M1_34250	COG2205	protein histidine kinase activity
K04M1_34280	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K04M1_34290	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K04M1_34370	COG1360	Flagellar Motor Protein
K04M1_34380	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K04M1_34390	COG1191	sigma factor activity
K04M1_34400	COG1580	Controls the rotational direction of flagella during chemotaxis
K04M1_34430	COG1516	flagellar protein fliS
K04M1_34440	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K04M1_34460	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K04M1_34490	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K04M1_34510	COG1987	bacterial-type flagellum assembly
K04M1_34560	COG2204	response regulator
K04M1_34590	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K04M1_34700	COG0346	lactoylglutathione lyase activity
K04M1_34750	COG0745	RESPONSE REGULATOR receiver
K04M1_34800	COG3300	MHYT domain
K04M1_34800	COG5001	Diguanylate cyclase
K04M1_34810	COG0156	8-amino-7-oxononanoate synthase activity
K04M1_34820	COG1063	alcohol dehydrogenase
K04M1_34890	COG0668	transmembrane transport
K04M1_34910	COG1304	FMN binding
K04M1_34920	COG1620	l-lactate permease
K04M1_34930	COG0583	DNA-binding transcription factor activity
K04M1_34940	COG1505	serine-type exopeptidase activity
K04M1_34950	COG4172	Belongs to the ABC transporter superfamily
K04M1_34970	COG1067	ATP-dependent peptidase activity
K04M1_34990	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K04M1_35030	COG1247	-acetyltransferase
K04M1_35040	COG0437	4 iron, 4 sulfur cluster binding
K04M1_35050	COG0348	domain, Protein
K04M1_35090	COG1122	ATPase activity
K04M1_35100	COG4720	Psort location CytoplasmicMembrane, score
K04M1_35110	COG1566	PFAM secretion protein HlyD family protein
K04M1_35130	COG3706	GGDEF domain
K04M1_35160	COG0813	purine-nucleoside phosphorylase activity
K04M1_35170	COG3272	Protein of unknown function (DUF1722)
K04M1_35180	COG0789	Transcriptional regulator
K04M1_35190	COG0415	Belongs to the DNA photolyase family
K04M1_35200	COG1388	LysM domain
K04M1_35200	COG1376	ErfK ybiS ycfS ynhG family protein
K04M1_35220	COG0513	Belongs to the DEAD box helicase family
K04M1_35230	COG1770	oligopeptidase
K04M1_35240	COG4771	TonB-dependent receptor
K04M1_35290	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K04M1_35300	COG0573	inorganic phosphate transmembrane transporter activity
K04M1_35310	COG0581	inorganic phosphate transmembrane transporter activity
K04M1_35320	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K04M1_35350	COG2304	oxidoreductase activity
K04M1_35390	COG0714	Associated with various cellular activities
K04M1_35420	COG2197	response regulator
K04M1_35490	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K04M1_35500	COG1120	ATPase activity
K04M1_35510	COG4774	siderophore transport
K04M1_35520	COG1132	(ABC) transporter
K04M1_35550	COG0569	domain protein
K04M1_35560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K04M1_35570	COG0583	DNA-binding transcription factor activity
K04M1_35610	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K04M1_35620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K04M1_35640	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
K04M1_35650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K04M1_35710	COG2084	Dehydrogenase
K04M1_35720	COG0753	catalase activity
K04M1_35740	COG2130	NADP-dependent
K04M1_35750	COG1309	transcriptional regulator
K04M1_35840	COG0489	protein tyrosine kinase activity
K04M1_35840	COG3206	protein involved in exopolysaccharide biosynthesis
K04M1_35870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K04M1_35880	COG3842	ATPase activity
K04M1_35900	COG1175	transmembrane transport
K04M1_35910	COG3833	ABC-type maltose transport systems, permease component
K04M1_35970	COG2354	Protein conserved in bacteria
K04M1_35980	COG0418	dihydroorotase activity
K04M1_35990	COG0401	homolog of Blt101
K04M1_36000	COG3217	Mosc domain protein beta barrel domain protein
K04M1_36000	COG0633	Ferredoxin
K04M1_36000	COG3217	Mosc domain protein beta barrel domain protein
K04M1_36000	COG0633	Ferredoxin
K04M1_36020	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K04M1_36100	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K04M1_36110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K04M1_36130	COG0848	biopolymer transport protein
K04M1_36140	COG0811	peptide transport
K04M1_36150	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K04M1_36170	COG3721	Heme iron utilization protein
K04M1_36180	COG0748	coenzyme F420 binding
K04M1_36200	COG0784	Response regulator, receiver
K04M1_36200	COG0835	chemotaxis
K04M1_36210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K04M1_36220	COG0534	Mate efflux family protein
K04M1_36230	COG0444	Belongs to the ABC transporter superfamily
K04M1_36240	COG4608	Belongs to the ABC transporter superfamily
K04M1_36250	COG0747	negative chemotaxis
K04M1_36270	COG1349	DNA-binding transcription factor activity
K04M1_36280	COG2084	Dehydrogenase
K04M1_36290	COG3395	kinase activity
K04M1_36300	COG0235	Class ii aldolase
K04M1_36310	COG3622	Belongs to the hyi family
K04M1_36320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K04M1_36330	COG2610	gluconate transmembrane transporter activity
K04M1_36370	COG0583	DNA-binding transcription factor activity
K04M1_36380	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K04M1_36400	COG4934	collagen metabolic process
K04M1_36420	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K04M1_36430	COG0789	Transcriptional regulator
K04M1_36440	COG0366	Alpha amylase catalytic
K04M1_36480	COG2249	NAD(P)H dehydrogenase (quinone) activity
K04M1_36490	COG0589	response to stress
K04M1_36500	COG0488	(ABC) transporter
K04M1_36510	COG1505	serine-type exopeptidase activity
K04M1_36530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K04M1_36550	COG2067	long-chain fatty acid transport protein
K04M1_36570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K04M1_36620	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K04M1_36660	COG3383	formate dehydrogenase (NAD+) activity
K04M1_36680	COG0842	Transport permease protein
K04M1_36690	COG1131	(ABC) transporter
K04M1_36730	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
K04M1_36750	COG4145	pantothenate transmembrane transporter activity
K04M1_36760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K04M1_36770	COG0800	Aldolase
K04M1_36790	COG2706	6-phosphogluconolactonase activity
K04M1_36800	COG0251	oxidation-reduction process
K04M1_36820	COG1881	PFAM PEBP family protein
K04M1_36840	COG0798	PFAM Bile acid sodium symporter
K04M1_36870	COG1733	regulation of RNA biosynthetic process
K04M1_36930	COG4989	oxidoreductase activity
K04M1_36980	COG0814	amino acid
K04M1_37050	COG0739	heme binding
K04M1_37060	COG5001	Diguanylate cyclase
K04M1_37070	COG0583	DNA-binding transcription factor activity
K04M1_37080	COG2814	Major facilitator Superfamily
K04M1_37120	COG0697	spore germination
K04M1_37150	COG0179	Fumarylacetoacetate (FAA) hydrolase
K04M1_37190	COG1280	lysine exporter protein (LysE YggA)
K04M1_37210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K04M1_37220	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K04M1_37240	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K04M1_37250	COG1845	cytochrome c oxidase, subunit III
K04M1_37280	COG1612	heme a metabolic process
K04M1_37290	COG0109	protoheme IX farnesyltransferase activity
K04M1_37300	COG0545	Peptidyl-prolyl cis-trans isomerase
K04M1_37360	COG1278	Cold shock
K04M1_37370	COG3036	rescue of stalled ribosome
K04M1_37380	COG2199	diguanylate cyclase activity
K04M1_37410	COG1132	(ABC) transporter
K04M1_37420	COG1132	(ABC) transporter
K04M1_37430	COG1538	Outer membrane efflux protein
K04M1_37440	COG2205	protein histidine kinase activity
K04M1_37440	COG0784	Response regulator, receiver
K04M1_37490	COG0840	transmembrane signaling receptor activity
K04M1_37510	COG0783	Belongs to the Dps family
K04M1_37530	COG2133	pyrroloquinoline quinone binding
K04M1_37540	COG1454	alcohol dehydrogenase
K04M1_37550	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
K04M1_37600	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K04M1_37610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K04M1_37620	COG3186	Phenylalanine-4-hydroxylase
K04M1_37670	COG3530	Putative quorum-sensing-regulated virulence factor
K04M1_37710	COG0513	Belongs to the DEAD box helicase family
K04M1_37720	COG4628	conserved protein (DUF2132)
K04M1_37740	COG0133	tryptophan synthase activity
K04M1_37750	COG1278	Cold shock
K04M1_37770	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
K04M1_37790	COG0523	cobalamin synthesis protein
K04M1_37800	COG0513	Belongs to the DEAD box helicase family
K04M1_37840	COG2200	EAL domain
K04M1_37850	COG1119	ATPase activity
K04M1_37890	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K04M1_37920	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
K04M1_37930	COG0513	Belongs to the DEAD box helicase family
K04M1_37940	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K04M1_37960	COG1073	alpha beta
K04M1_37970	COG1073	alpha beta
K04M1_38000	COG0730	response to heat
K04M1_38030	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K04M1_38050	COG0523	cobalamin synthesis protein
K04M1_38060	COG2988	succinylglutamate desuccinylase activity
K04M1_38070	COG0739	heme binding
K04M1_38090	COG0523	cobalamin synthesis protein
K04M1_38110	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K04M1_38120	COG2095	MarC family integral membrane protein
K04M1_38170	COG1024	Enoyl-CoA hydratase
K04M1_38180	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K04M1_38190	COG1960	acyl-CoA dehydrogenase activity
K04M1_38210	COG0183	Belongs to the thiolase family
K04M1_38240	COG1024	Enoyl-CoA hydratase
K04M1_38250	COG1024	Enoyl-CoA hydratase
K04M1_38270	COG1028	Short-chain dehydrogenase reductase Sdr
K04M1_38280	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K04M1_38290	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K04M1_38300	COG1845	cytochrome c oxidase, subunit III
K04M1_38310	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K04M1_38320	COG0109	protoheme IX farnesyltransferase activity
K04M1_38330	COG0446	pyridine nucleotide-disulphide oxidoreductase
K04M1_38330	COG1902	pentaerythritol trinitrate reductase activity
K04M1_38360	COG1012	belongs to the aldehyde dehydrogenase family
K04M1_38380	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K04M1_38440	COG1126	abc transporter atp-binding protein
K04M1_38450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K04M1_38460	COG4215	(ABC) transporter
K04M1_38470	COG4160	amino acid transport
K04M1_38610	COG0443	Heat shock 70 kDa protein
K04M1_38620	COG2847	Copper chaperone PCu(A)C
K04M1_38730	COG3706	GGDEF domain
K04M1_38750	COG0814	amino acid
K04M1_38770	COG0243	molybdopterin cofactor binding
K04M1_38810	COG3707	response regulator
K04M1_38820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K04M1_38820	COG1116	anion transmembrane transporter activity
K04M1_38830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K04M1_38840	COG1116	anion transmembrane transporter activity
K04M1_38850	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K04M1_38850	COG2146	nitrite reductase [NAD(P)H] activity
K04M1_38950	COG0515	serine threonine protein kinase
K04M1_38950	COG2815	serine threonine protein kinase
K04M1_39020	COG0631	protein serine/threonine phosphatase activity
K04M1_39130	COG3501	Rhs element vgr protein
K04M1_39160	COG0420	3'-5' exonuclease activity
K04M1_39170	COG0419	ATPase involved in DNA repair
K04M1_39190	COG3040	lipid binding
K04M1_39210	COG1288	antiporter activity
K04M1_39230	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
K04M1_39260	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K04M1_39290	COG0583	DNA-binding transcription factor activity
K04M1_39300	COG0277	FAD linked oxidase domain protein
K04M1_39330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K04M1_39400	COG2176	DNA-directed DNA polymerase activity
K04M1_39490	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
K04M1_39500	COG1328	CTP reductase activity
K04M1_39950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K04M1_39990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K04M1_40010	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K04M1_40020	COG2146	nitrite reductase [NAD(P)H] activity
K04M1_40030	COG2116	formate transmembrane transporter activity
K04M1_40070	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K04M1_40130	COG2814	Major facilitator Superfamily
K04M1_40140	COG3118	belongs to the thioredoxin family
K04M1_40150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K04M1_40200	COG2271	Major facilitator Superfamily
K04M1_40210	COG3851	Histidine kinase
K04M1_40220	COG2197	response regulator
K04M1_40240	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K04M1_40250	COG0583	DNA-binding transcription factor activity
K04M1_40260	COG0243	molybdopterin cofactor binding
K04M1_40290	COG0384	phenazine biosynthesis protein PhzF
K04M1_40300	COG1794	racemase activity, acting on amino acids and derivatives
K04M1_40360	COG1328	CTP reductase activity
K04M1_40370	COG0602	queuosine metabolic process
K04M1_40380	COG0534	Mate efflux family protein
K04M1_40390	COG2207	Transcriptional regulator
K04M1_40410	COG0189	ligase activity
K04M1_40410	COG4067	protein conserved in archaea
K04M1_40430	COG3111	PFAM Bacterial OB fold (BOF) protein
K04M1_40450	COG0725	ABC transporter, periplasmic molybdate-binding protein
K04M1_40460	COG4149	molybdate abc transporter
K04M1_40470	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K04M1_40490	COG2203	Gaf domain
K04M1_40490	COG3706	GGDEF domain
K04M1_40490	COG5001	Diguanylate cyclase
K04M1_40490	COG4251	negative regulation of phosphorylation
K04M1_40500	COG0745	RESPONSE REGULATOR receiver
K04M1_40500	COG3706	GGDEF domain
K04M1_40530	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K04M1_40540	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K04M1_40590	COG3140	Belongs to the UPF0181 family
K04M1_40620	COG0583	DNA-binding transcription factor activity
K04M1_40920	COG0023	Translation Initiation Factor
K04M1_40940	COG1181	Belongs to the D-alanine--D-alanine ligase family
K04M1_40960	COG1042	CoA-binding domain protein
K04M1_40960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K04M1_40960	COG0045	succinate-CoA ligase (ADP-forming) activity
K04M1_40970	COG0583	DNA-binding transcription factor activity
K04M1_41000	COG3447	MASE1 domain protein
K04M1_41000	COG5002	protein histidine kinase activity
K04M1_41000	COG5001	Diguanylate cyclase
K04M1_41010	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K04M1_41020	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K04M1_41030	COG1984	allophanate hydrolase subunit 2
K04M1_41050	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K04M1_41060	COG4181	ATPase activity
K04M1_41080	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K04M1_41090	COG3300	MHYT domain
K04M1_41090	COG5001	Diguanylate cyclase
K04M1_41160	COG4533	DNA binding
K04M1_41180	COG2050	protein possibly involved in aromatic compounds catabolism
K04M1_41210	COG2067	long-chain fatty acid transport protein
K04M1_41220	COG2267	carboxylic ester hydrolase activity
K04M1_41260	COG0861	Integral membrane protein TerC family
K04M1_41270	COG0737	Belongs to the 5'-nucleotidase family
K04M1_41280	COG3593	DNA synthesis involved in DNA repair
K04M1_41300	COG0583	DNA-binding transcription factor activity
K04M1_41320	COG2116	formate transmembrane transporter activity
K04M1_41330	COG2353	YceI-like domain
K04M1_41340	COG3038	cytochrome b561
K04M1_41380	COG0513	Belongs to the DEAD box helicase family
K04M1_41390	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
K04M1_41410	COG0840	transmembrane signaling receptor activity
K04M1_41420	COG0546	phosphoglycolate phosphatase activity
K04M1_41450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K04M1_41460	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K04M1_41470	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K04M1_41490	COG2207	Transcriptional regulator
K04M1_41500	COG1979	alcohol dehydrogenase
K04M1_41520	COG1126	abc transporter atp-binding protein
K04M1_41530	COG0765	amino acid transport
K04M1_41540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K04M1_41550	COG0765	amino acid transport
K04M1_41560	COG2199	diguanylate cyclase activity
K04M1_41560	COG2203	Gaf domain
K04M1_41560	COG2200	EAL domain
K04M1_41590	COG1609	Transcriptional regulator
K04M1_41600	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K04M1_41600	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K04M1_41610	COG1105	Belongs to the carbohydrate kinase PfkB family
K04M1_41620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K04M1_41620	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
K04M1_41620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K04M1_41680	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K04M1_41700	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K04M1_41710	COG0509	glycine decarboxylation via glycine cleavage system
K04M1_41730	COG0346	lactoylglutathione lyase activity
K04M1_41740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K04M1_41750	COG0583	DNA-binding transcription factor activity
K04M1_41760	COG0697	spore germination
K04M1_41770	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K04M1_41830	COG2176	DNA-directed DNA polymerase activity
K04M1_41910	COG0242	peptide deformylase activity
K04M1_41970	COG2239	Acts as a magnesium transporter
K04M1_42010	COG0346	lactoylglutathione lyase activity
K04M1_42020	COG1902	pentaerythritol trinitrate reductase activity
K04M1_42040	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K04M1_42040	COG2755	lipolytic protein G-D-S-L family
K04M1_42070	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K04M1_42080	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K04M1_42080	COG0069	glutamate synthase activity
K04M1_42140	COG2076	Multidrug Resistance protein
K04M1_42180	COG2962	Rard protein
K04M1_42210	COG0784	Response regulator, receiver
K04M1_42210	COG0835	chemotaxis
K04M1_42220	COG2197	response regulator
K04M1_42240	COG3706	GGDEF domain
K04M1_42250	COG2197	response regulator
K04M1_42260	COG3300	MHYT domain
K04M1_42260	COG5001	Diguanylate cyclase
K04M1_42270	COG0784	Response regulator, receiver
K04M1_42270	COG2205	protein histidine kinase activity
K04M1_42280	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K04M1_42320	COG0456	acetyltransferase
K04M1_42320	COG1214	PFAM Peptidase M22, glycoprotease
K04M1_42340	COG3069	C4-dicarboxylate transmembrane transporter activity
K04M1_42390	COG3111	PFAM Bacterial OB fold (BOF) protein
K04M1_42400	COG1597	lipid kinase activity
K04M1_42410	COG0583	DNA-binding transcription factor activity
K04M1_42420	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K04M1_42480	COG0714	Associated with various cellular activities
K04M1_42490	COG0641	radical SAM
K04M1_42500	COG3119	arylsulfatase activity
K04M1_42520	COG3119	arylsulfatase activity
K04M1_42530	COG0745	RESPONSE REGULATOR receiver
K04M1_42560	COG2205	protein histidine kinase activity
K04M1_42560	COG0784	Response regulator, receiver
K04M1_42560	COG2198	Histidine kinase
K04M1_42570	COG1879	ABC-type sugar transport system periplasmic component
K04M1_42590	COG0745	RESPONSE REGULATOR receiver
K04M1_42620	COG2198	Histidine kinase
K04M1_42620	COG0784	Response regulator, receiver
K04M1_42620	COG2205	protein histidine kinase activity
K04M1_42630	COG1879	ABC-type sugar transport system periplasmic component
K04M1_42640	COG1803	Methylglyoxal synthase
K04M1_42650	COG0210	DNA helicase
K04M1_42660	COG1289	transmembrane transporter activity
K04M1_42720	COG1629	transport
K04M1_42720	COG4771	TonB-dependent receptor
K04M1_42740	COG0789	Transcriptional regulator
K04M1_42750	COG4604	ABC transporter, ATP-binding protein
K04M1_42760	COG4605	iron ion homeostasis
K04M1_42770	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K04M1_42780	COG4607	ABC-type enterochelin transport system periplasmic component
K04M1_42800	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
K04M1_42830	COG1609	Transcriptional regulator
K04M1_42840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K04M1_42850	COG1879	ABC-type sugar transport system periplasmic component
K04M1_42860	COG1172	Belongs to the binding-protein-dependent transport system permease family
K04M1_42870	COG1129	ABC transporter
K04M1_42880	COG1869	D-ribose catabolic process
K04M1_42890	COG5001	Diguanylate cyclase
K04M1_42990	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K04M1_43010	COG2205	protein histidine kinase activity
K04M1_43010	COG0784	Response regulator, receiver
K04M1_43040	COG0330	HflC and HflK could
K04M1_43070	COG0517	IMP dehydrogenase activity
K04M1_43070	COG4175	Glycine betaine
K04M1_43080	COG4176	ABC-type proline glycine betaine transport system permease component
K04M1_43110	COG1012	belongs to the aldehyde dehydrogenase family
K04M1_43120	COG1309	transcriptional regulator
K04M1_43130	COG0745	RESPONSE REGULATOR receiver
K04M1_43130	COG3706	GGDEF domain
K04M1_43140	COG1028	Short-chain dehydrogenase reductase Sdr
K04M1_43170	COG1024	Enoyl-CoA hydratase
K04M1_43180	COG1960	acyl-CoA dehydrogenase activity
K04M1_43200	COG0183	Belongs to the thiolase family
K04M1_43220	COG1960	acyl-CoA dehydrogenase activity
K04M1_43230	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K04M1_43280	COG3264	Mechanosensitive ion channel
K04M1_43280	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K04M1_43290	COG0110	maltose O-acetyltransferase activity
K04M1_43300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K04M1_43310	COG1271	oxidase subunit
K04M1_43320	COG1294	oxidase, subunit
K04M1_43340	COG0384	phenazine biosynthesis protein PhzF
K04M1_43380	COG3527	Alpha-acetolactate decarboxylase
K04M1_43400	COG1028	Short-chain dehydrogenase reductase Sdr
K04M1_43410	COG0500	methyltransferase
K04M1_43470	COG1022	Amp-dependent synthetase and ligase
K04M1_43520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K04M1_43530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K04M1_43530	COG1263	PTS System
K04M1_43540	COG1486	melibiose metabolic process
K04M1_43550	COG2188	Transcriptional regulator
K04M1_43560	COG1320	monovalent cation:proton antiporter activity
K04M1_43570	COG2212	antiporter activity
K04M1_43600	COG1006	Multisubunit Na H antiporter MnhC subunit
K04M1_43610	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K04M1_43610	COG2111	Na H antiporter
K04M1_43630	COG0589	response to stress
K04M1_43640	COG4221	oxidoreductase activity
K04M1_43650	COG0583	DNA-binding transcription factor activity
K04M1_43670	COG2814	Major facilitator Superfamily
K04M1_43800	COG1522	sequence-specific DNA binding
K04M1_43870	COG0515	serine threonine protein kinase
K04M1_43920	COG3501	Rhs element vgr protein
K04M1_43950	COG2204	response regulator
K04M1_44000	COG0739	heme binding
K04M1_44030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K04M1_44130	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K04M1_44150	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K04M1_44150	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K04M1_44180	COG4989	oxidoreductase activity
K04M1_44210	COG0038	chloride channel
K04M1_44280	COG2897	thiosulfate sulfurtransferase activity
K04M1_44300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K04M1_44310	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K04M1_44320	COG0840	transmembrane signaling receptor activity
K04M1_44330	COG2814	Major facilitator Superfamily
K04M1_44340	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K04M1_44360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K04M1_44380	COG0840	transmembrane signaling receptor activity
K04M1_44420	COG2195	Cleaves the N-terminal amino acid of tripeptides
K04M1_44450	COG2197	response regulator
K04M1_44460	COG3850	Histidine kinase
K04M1_44470	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K04M1_44490	COG0243	molybdopterin cofactor binding
K04M1_44510	COG3005	denitrification pathway
K04M1_44530	COG3243	poly(R)-hydroxyalkanoic acid synthase
K04M1_44550	COG0183	Belongs to the thiolase family
K04M1_44570	COG1280	lysine exporter protein (LysE YggA)
K04M1_44590	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K04M1_44600	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K04M1_44700	COG1846	Transcriptional regulator
K04M1_44710	COG2205	protein histidine kinase activity
K04M1_44710	COG0784	Response regulator, receiver
K04M1_44720	COG1879	ABC-type sugar transport system periplasmic component
K04M1_44730	COG2827	Endonuclease containing a URI domain
K04M1_44740	COG3132	Protein of unknown function, DUF480
K04M1_44780	COG5002	protein histidine kinase activity
K04M1_44780	COG2205	protein histidine kinase activity
K04M1_44780	COG0784	Response regulator, receiver
K04M1_44840	COG0583	DNA-binding transcription factor activity
K04M1_44860	COG0531	amino acid
K04M1_44890	COG2205	protein histidine kinase activity
K04M1_44900	COG0745	RESPONSE REGULATOR receiver
K04M1_44960	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K04M1_44970	COG2239	Acts as a magnesium transporter
K04M1_44980	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K04M1_44990	COG0402	S-adenosylhomocysteine deaminase activity
K04M1_45000	COG1418	mRNA catabolic process
K04M1_45020	COG2814	Major facilitator Superfamily
K04M1_45040	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K04M1_45080	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K04M1_45110	COG0745	RESPONSE REGULATOR receiver
K04M1_45120	COG2205	protein histidine kinase activity
K04M1_45140	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K04M1_45150	COG2194	sulfuric ester hydrolase activity
K04M1_45190	COG4667	esterase of the alpha-beta hydrolase superfamily
K04M1_45200	COG1741	Belongs to the pirin family
K04M1_45210	COG1278	Cold shock
K04M1_45240	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K04M1_45250	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K04M1_45250	COG0678	peroxiredoxin activity
K04M1_45270	COG1686	Belongs to the peptidase S11 family
K04M1_45290	COG0625	glutathione transferase activity
K04M1_45300	COG1621	beta-fructofuranosidase activity
K04M1_45310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K04M1_45320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K04M1_45320	COG1263	PTS System
K04M1_45360	COG1028	Short-chain dehydrogenase reductase Sdr
K04M1_45390	COG3746	phosphate-selective porin O and P
K04M1_45420	COG0300	oxidoreductase activity
K04M1_45430	COG0583	DNA-binding transcription factor activity
K04M1_45440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K04M1_45440	COG2207	Transcriptional regulator
K04M1_45450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K04M1_45490	COG0513	Belongs to the DEAD box helicase family
K04M1_45510	COG0583	DNA-binding transcription factor activity
K04M1_45540	COG1902	pentaerythritol trinitrate reductase activity
K04M1_45550	COG1063	alcohol dehydrogenase
K04M1_45570	COG1028	Short-chain dehydrogenase reductase Sdr
K04M1_45590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K04M1_45600	COG0006	proline dipeptidase activity
K04M1_45610	COG3608	succinylglutamate desuccinylase aspartoacylase
K04M1_45620	COG1522	sequence-specific DNA binding
K04M1_45630	COG1012	belongs to the aldehyde dehydrogenase family
K04M1_45640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K04M1_45650	COG3122	Protein conserved in bacteria
K04M1_45680	COG0583	DNA-binding transcription factor activity
K04M1_45700	COG0252	asparaginase activity
K04M1_45710	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K04M1_45740	COG2197	response regulator
K04M1_45750	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K04M1_45760	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K04M1_45800	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K04M1_45860	COG3842	ATPase activity
K04M1_45900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K04M1_45960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K04M1_45970	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K04M1_46030	COG0583	DNA-binding transcription factor activity
K04M1_46050	COG4948	Mandelate Racemase Muconate Lactonizing
K04M1_46060	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K04M1_46110	COG1342	Belongs to the UPF0251 family
K04M1_46120	COG4176	ABC-type proline glycine betaine transport system permease component
K04M1_46130	COG3448	diguanylate cyclase activity
K04M1_46130	COG4175	Glycine betaine
K04M1_46140	COG3015	lipoprotein NlpE involved in copper resistance
K04M1_46150	COG3713	MltA-interacting MipA family protein
K04M1_46180	COG0583	DNA-binding transcription factor activity
K04M1_46230	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K04M1_46250	COG1335	isochorismatase
K04M1_46280	COG1349	DNA-binding transcription factor activity
K04M1_46300	COG2070	2-Nitropropane dioxygenase
K04M1_46310	COG0531	amino acid
K04M1_46320	COG4302	ethanolamine ammonia-lyase activity
K04M1_46330	COG4303	Ethanolamine ammonia lyase large subunit
K04M1_46350	COG1309	transcriptional regulator
K04M1_46390	COG1280	lysine exporter protein (LysE YggA)
K04M1_46410	COG0459	protein refolding
K04M1_46420	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K04M1_46430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K04M1_46460	COG1304	FMN binding
K04M1_46510	COG1256	bacterial-type flagellum assembly
K04M1_46510	COG4786	Flagellar basal body rod
K04M1_46530	COG1706	bacterial-type flagellum-dependent cell motility
K04M1_46540	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K04M1_46550	COG4786	Flagellar basal body rod
K04M1_46560	COG4787	bacterial-type flagellum-dependent cell motility
K04M1_46570	COG1749	Flagellar hook protein flgE
K04M1_46580	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K04M1_46590	COG1558	bacterial-type flagellum-dependent cell motility
K04M1_46600	COG1815	bacterial-type flagellum-dependent cell motility
K04M1_46640	COG0741	lytic transglycosylase activity
K04M1_46650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K04M1_46690	COG1760	l-serine dehydratase
K04M1_46720	COG0583	DNA-binding transcription factor activity
K04M1_46740	COG2866	Carboxypeptidase
K04M1_46750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K04M1_46770	COG2990	Protein conserved in bacteria
K04M1_46820	COG3842	ATPase activity
K04M1_46840	COG1840	ABC-type Fe3 transport system, periplasmic component
K04M1_46880	COG1609	Transcriptional regulator
K04M1_46940	COG3240	lipase activity
K04M1_46950	COG1309	transcriptional regulator
K04M1_46980	COG0577	efflux transmembrane transporter activity
K04M1_46980	COG1136	(ABC) transporter
K04M1_46990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K04M1_47000	COG2067	long-chain fatty acid transport protein
K04M1_47010	COG3338	carbonate dehydratase activity
K04M1_47020	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K04M1_47050	COG1011	Hydrolase
K04M1_47120	COG0110	maltose O-acetyltransferase activity
K04M1_47130	COG1765	OsmC-like protein
K04M1_47140	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K04M1_47140	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K04M1_47160	COG3046	protein related to deoxyribodipyrimidine photolyase
K04M1_47170	COG0415	Belongs to the DNA photolyase family
K04M1_47180	COG3706	GGDEF domain
K04M1_47210	COG3706	GGDEF domain
K04M1_47240	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K04M1_47270	COG3033	Beta-eliminating lyase
K04M1_47300	COG1271	oxidase subunit
K04M1_47310	COG1294	oxidase, subunit
K04M1_47340	COG3179	chitinase
K04M1_47350	COG0579	oxidoreductase
K04M1_47400	COG3706	GGDEF domain
K04M1_47460	COG0583	DNA-binding transcription factor activity
K04M1_47500	COG0189	ligase activity
K04M1_47510	COG0189	ligase activity
K04M1_47510	COG4067	protein conserved in archaea
K04M1_47530	COG1166	arginine decarboxylase activity
K04M1_47540	COG0010	Belongs to the arginase family
K04M1_47550	COG2814	Major facilitator Superfamily
K04M1_47560	COG1770	oligopeptidase
K04M1_47590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K04M1_47600	COG1121	(ABC) transporter
K04M1_47610	COG0803	Belongs to the bacterial solute-binding protein 9 family
K04M1_47690	COG0848	biopolymer transport protein
K04M1_47700	COG0811	peptide transport
K04M1_47710	COG0811	peptide transport
K04M1_47750	COG0745	RESPONSE REGULATOR receiver
K04M1_47760	COG0584	glycerophosphoryl diester phosphodiesterase
K04M1_47780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K04M1_47910	COG0312	modulator of DNA gyrase
K04M1_47920	COG0312	modulator of DNA gyrase
K04M1_47930	COG0351	phosphomethylpyrimidine kinase
K04M1_47940	COG1116	anion transmembrane transporter activity
K04M1_47950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K04M1_47960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K04M1_47970	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K04M1_48010	COG0243	molybdopterin cofactor binding
K04M1_48020	COG3005	denitrification pathway
K04M1_48030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K04M1_48040	COG1028	Short-chain dehydrogenase reductase Sdr
K04M1_48070	COG0456	acetyltransferase
K04M1_48110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K04M1_48120	COG1929	Belongs to the glycerate kinase type-1 family
K04M1_48130	COG2610	gluconate transmembrane transporter activity
K04M1_48140	COG3835	regulator
K04M1_48270	COG3047	cAMP biosynthetic process
K04M1_48290	COG1357	PFAM Pentapeptide repeats (8 copies)
K04M1_48350	COG2375	cellular response to nickel ion
K04M1_48360	COG0583	DNA-binding transcription factor activity
K04M1_48370	COG2162	N-hydroxyarylamine O-acetyltransferase activity
K04M1_48380	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K04M1_48430	COG2199	diguanylate cyclase activity
K04M1_48450	COG0561	phosphatase activity
K04M1_48460	COG0583	DNA-binding transcription factor activity
K04M1_48490	COG0564	pseudouridine synthase activity
K04M1_48500	COG0534	Mate efflux family protein
K04M1_48510	COG5001	Diguanylate cyclase
K04M1_48530	COG3123	guanosine phosphorylase activity
K04M1_48560	COG0596	Alpha beta hydrolase
K04M1_48620	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K04M1_48640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K04M1_48650	COG2169	Transcriptional regulator
K04M1_48650	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K04M1_48670	COG2259	Doxx family
K04M1_48680	COG1741	Belongs to the pirin family
K04M1_48720	COG0363	glucosamine-6-phosphate deaminase activity
K04M1_48740	COG0786	glutamate:sodium symporter activity
K04M1_48750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K04M1_48760	COG1131	(ABC) transporter
K04M1_48780	COG0786	glutamate:sodium symporter activity
K04M1_48820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K04M1_48840	COG3279	Response regulator of the LytR AlgR family
K04M1_48850	COG3275	phosphorelay sensor kinase activity
K04M1_48910	COG0772	Belongs to the SEDS family
K04M1_48960	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K04M1_48960	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
K04M1_48980	COG0444	Belongs to the ABC transporter superfamily
K04M1_48990	COG4608	Belongs to the ABC transporter superfamily
K04M1_49940	COG0358	DNA primase activity
K04M1_50280	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K04M1_50670	COG2916	Histone family protein nucleoid-structuring protein H-NS
K04M1_51220	COG0330	HflC and HflK could
K04M1_51230	COG0330	HflC and HflK could
K04M1_51340	COG4251	negative regulation of phosphorylation
K04M1_51340	COG3706	GGDEF domain
K04M1_51340	COG5001	Diguanylate cyclase
K04M1_51340	COG2203	Gaf domain
K04M1_51640	COG0358	DNA primase activity
K04M1_52430	COG4128	Pfam Zonular occludens toxin