locus-tag	class	description
K05K4_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K05K4_00020	COG0592	DNA-directed DNA polymerase activity
K05K4_00040	COG0187	DNA topoisomerase II activity
K05K4_00070	COG0071	Belongs to the small heat shock protein (HSP20) family
K05K4_00080	COG3977	Valine--pyruvate aminotransferase
K05K4_00090	COG0366	Alpha amylase catalytic
K05K4_00120	COG2119	membrane
K05K4_00140	COG0425	Belongs to the sulfur carrier protein TusA family
K05K4_00170	COG0604	alcohol dehydrogenase
K05K4_00180	COG0183	Belongs to the thiolase family
K05K4_00200	COG1739	Uncharacterized protein family UPF0029
K05K4_00210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K05K4_00290	COG0583	DNA-binding transcription factor activity
K05K4_00300	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K05K4_00310	COG2960	long-chain fatty acid transporting porin activity
K05K4_00320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K05K4_00330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K05K4_00430	COG4172	Belongs to the ABC transporter superfamily
K05K4_00440	COG4166	transmembrane transport
K05K4_00460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K05K4_00480	COG1609	Transcriptional regulator
K05K4_00490	COG0583	DNA-binding transcription factor activity
K05K4_00510	COG2076	Multidrug Resistance protein
K05K4_00520	COG0129	dihydroxy-acid dehydratase activity
K05K4_00530	COG3265	gluconokinase activity
K05K4_00540	COG2610	gluconate transmembrane transporter activity
K05K4_00550	COG0800	Aldolase
K05K4_00560	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K05K4_00570	COG0583	DNA-binding transcription factor activity
K05K4_00580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K05K4_00590	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K05K4_00610	COG1522	sequence-specific DNA binding
K05K4_00620	COG5001	Diguanylate cyclase
K05K4_00620	COG5002	protein histidine kinase activity
K05K4_00630	COG0742	ribosomal rna small subunit methyltransferase
K05K4_00650	COG0697	spore germination
K05K4_00660	COG0589	response to stress
K05K4_00670	COG1528	Iron-storage protein
K05K4_00690	COG2081	HI0933 family
K05K4_00750	COG1597	lipid kinase activity
K05K4_00810	COG0628	permease
K05K4_00840	COG1322	Protein conserved in bacteria
K05K4_00850	COG2226	methyltransferase
K05K4_00860	COG3165	ubiquinone biosynthetic process from chorismate
K05K4_00870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K05K4_00900	COG0805	protein transport
K05K4_00910	COG0084	hydrolase, TatD family'
K05K4_00930	COG0456	acetyltransferase
K05K4_00950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K05K4_00950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K05K4_00960	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K05K4_01010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K05K4_01020	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K05K4_01040	COG2204	response regulator
K05K4_01050	COG3852	Histidine kinase
K05K4_01070	COG0174	glutamine synthetase
K05K4_01090	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K05K4_01110	COG1295	ribonuclease BN
K05K4_01120	COG1490	D-aminoacyl-tRNA deacylase activity
K05K4_01130	COG0456	acetyltransferase
K05K4_01150	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K05K4_01160	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K05K4_01170	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K05K4_01180	COG3031	protein transport across the cell outer membrane
K05K4_01200	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K05K4_01210	COG1459	type II secretion system
K05K4_01220	COG2165	general secretion pathway protein
K05K4_01230	COG2165	general secretion pathway protein
K05K4_01240	COG2165	general secretion pathway protein
K05K4_01250	COG4795	General secretion pathway protein
K05K4_01260	COG3156	type II secretion system protein K
K05K4_01270	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K05K4_01280	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K05K4_01300	COG1218	3'(2'),5'-bisphosphate nucleotidase
K05K4_01310	COG0494	nUDIX hydrolase
K05K4_01330	COG1040	competence protein
K05K4_01360	COG2183	response to ionizing radiation
K05K4_01380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K05K4_01400	COG0745	RESPONSE REGULATOR receiver
K05K4_01410	COG2205	protein histidine kinase activity
K05K4_01420	COG2233	PERMEase
K05K4_01430	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K05K4_01440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K05K4_01450	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K05K4_01460	COG1758	RNA polymerase activity
K05K4_01470	COG0194	GDP metabolic process
K05K4_01500	COG0848	biopolymer transport protein
K05K4_01510	COG0811	peptide transport
K05K4_01550	COG4174	ABC transporter (Permease)
K05K4_01560	COG4239	(ABC) transporter, permease
K05K4_01570	COG0747	negative chemotaxis
K05K4_01580	COG0444	Belongs to the ABC transporter superfamily
K05K4_01590	COG4608	Belongs to the ABC transporter superfamily
K05K4_01610	COG1561	YicC-like family, N-terminal region
K05K4_01620	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K05K4_01630	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K05K4_01640	COG1560	Kdo2-lipid A biosynthetic process
K05K4_01650	COG1309	transcriptional regulator
K05K4_01660	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K05K4_01680	COG2003	Belongs to the UPF0758 family
K05K4_01730	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K05K4_01760	COG0463	Glycosyl transferase, family 2
K05K4_01770	COG0859	PFAM glycosyl transferase family 9
K05K4_01780	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K05K4_01790	COG3642	lipopolysaccharide core region biosynthetic process
K05K4_01810	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K05K4_01890	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K05K4_01900	COG1519	Transferase
K05K4_01910	COG0859	PFAM glycosyl transferase family 9
K05K4_01930	COG1560	Kdo2-lipid A biosynthetic process
K05K4_01970	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K05K4_02070	COG0438	transferase activity, transferring glycosyl groups
K05K4_02090	COG0438	transferase activity, transferring glycosyl groups
K05K4_02090	COG0297	glycogen (starch) synthase activity
K05K4_02110	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K05K4_02120	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K05K4_02130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K05K4_02190	COG1215	transferase activity, transferring glycosyl groups
K05K4_02240	COG0149	triose-phosphate isomerase activity
K05K4_02290	COG1494	fructose-1,6-bisphosphatase
K05K4_02310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K05K4_02320	COG1575	Belongs to the MenA family. Type 1 subfamily
K05K4_02380	COG2003	Belongs to the UPF0758 family
K05K4_02410	COG4565	transcriptional regulatory protein
K05K4_02430	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K05K4_02440	COG0511	ligase activity, forming carbon-carbon bonds
K05K4_02440	COG5016	pyruvate
K05K4_02450	COG3630	sodium ion export across plasma membrane
K05K4_02470	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
K05K4_02480	COG3052	prosthetic group binding
K05K4_02490	COG2301	Belongs to the HpcH HpaI aldolase family
K05K4_02500	COG3051	citrate lyase alpha subunit
K05K4_02510	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
K05K4_02520	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
K05K4_02550	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K05K4_02560	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K05K4_02590	COG1609	Transcriptional regulator
K05K4_02600	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K05K4_02610	COG0254	rRNA binding
K05K4_02630	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K05K4_02640	COG0088	Forms part of the polypeptide exit tunnel
K05K4_02660	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K05K4_02670	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K05K4_02680	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K05K4_02690	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K05K4_02710	COG0255	Belongs to the universal ribosomal protein uL29 family
K05K4_02720	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K05K4_02740	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K05K4_02750	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K05K4_02760	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K05K4_02770	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K05K4_02780	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K05K4_02810	COG1841	ribosomal large subunit assembly
K05K4_02830	COG0201	protein transport
K05K4_02850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K05K4_02860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K05K4_02880	COG0202	RNA polymerase activity
K05K4_02890	COG0203	ribosomal protein L17
K05K4_02910	COG0545	Peptidyl-prolyl cis-trans isomerase
K05K4_02930	COG2153	protein acetylation
K05K4_02940	COG0513	Belongs to the DEAD box helicase family
K05K4_02970	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K05K4_02970	COG1648	precorrin-2 dehydrogenase activity
K05K4_02980	COG0175	sulfate reduction
K05K4_02990	COG2895	sulfate adenylyltransferase (ATP) activity
K05K4_03000	COG0471	metal ion transport
K05K4_03000	COG3273	potassium ion transport
K05K4_03010	COG0529	Catalyzes the synthesis of activated sulfate
K05K4_03060	COG4181	ATPase activity
K05K4_03090	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K05K4_03110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K05K4_03120	COG0729	surface antigen
K05K4_03130	COG2911	Protein conserved in bacteria
K05K4_03140	COG2105	PFAM AIG2 family protein
K05K4_03160	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K05K4_03170	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K05K4_03180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K05K4_03190	COG0163	prenyltransferase activity
K05K4_03200	COG4143	(ABC) transporter
K05K4_03210	COG1178	ABC-type Fe3 transport system permease component
K05K4_03220	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K05K4_03230	COG0583	DNA-binding transcription factor activity
K05K4_03240	COG1902	pentaerythritol trinitrate reductase activity
K05K4_03310	COG0142	geranyltranstransferase activity
K05K4_03320	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K05K4_03340	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K05K4_03350	COG2966	Psort location CytoplasmicMembrane, score
K05K4_03370	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K05K4_03380	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K05K4_03390	COG2967	ApaG domain
K05K4_03400	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K05K4_03410	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K05K4_03420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K05K4_03430	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K05K4_03440	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K05K4_03480	COG0473	3-isopropylmalate dehydrogenase activity
K05K4_03490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K05K4_03530	COG0583	DNA-binding transcription factor activity
K05K4_03540	COG1022	Amp-dependent synthetase and ligase
K05K4_03550	COG0028	Belongs to the TPP enzyme family
K05K4_03560	COG0440	acetolactate synthase activity
K05K4_03570	COG3706	GGDEF domain
K05K4_03590	COG0469	pyruvate kinase activity
K05K4_03600	COG1349	DNA-binding transcription factor activity
K05K4_03610	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K05K4_03630	COG2376	Dihydroxyacetone kinase
K05K4_03640	COG1461	Dihydroxyacetone kinase
K05K4_03670	COG3722	fumarate hydratase activity
K05K4_03690	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K05K4_03690	COG2213	PTS system mannitol-specific
K05K4_03750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K05K4_03760	COG0358	DNA primase activity
K05K4_03770	COG1610	YqeY-like protein
K05K4_03780	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K05K4_03790	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K05K4_03800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K05K4_03810	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K05K4_03820	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K05K4_03830	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K05K4_03840	COG1968	undecaprenyl-diphosphatase activity
K05K4_03860	COG3409	Peptidoglycan-binding domain 1 protein
K05K4_03860	COG3267	Type II secretory pathway component ExeA
K05K4_03880	COG0405	Gamma-glutamyltransferase
K05K4_03890	COG4991	sh3 domain protein
K05K4_03900	COG0306	phosphate transporter
K05K4_03910	COG1392	Phosphate transport regulator
K05K4_03920	COG3025	triphosphatase activity
K05K4_03950	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K05K4_03960	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K05K4_03960	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K05K4_03970	COG1538	Outer membrane efflux protein
K05K4_03980	COG0494	nUDIX hydrolase
K05K4_03990	COG3151	Protein conserved in bacteria
K05K4_04010	COG3150	esterase
K05K4_04020	COG0187	DNA topoisomerase II activity
K05K4_04030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K05K4_04040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K05K4_04060	COG3105	Protein conserved in bacteria
K05K4_04070	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K05K4_04090	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K05K4_04100	COG0723	plastoquinol--plastocyanin reductase activity
K05K4_04110	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K05K4_04120	COG2857	Cytochrome c1
K05K4_04130	COG0625	glutathione transferase activity
K05K4_04140	COG2969	positive regulation of protein catabolic process
K05K4_04170	COG2823	Periplasmic or secreted lipoprotein
K05K4_04180	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K05K4_04210	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K05K4_04230	COG3116	cell division
K05K4_04240	COG0768	penicillin binding
K05K4_04250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K05K4_04260	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K05K4_04270	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K05K4_04360	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K05K4_04430	COG3116	cell division
K05K4_04480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K05K4_04490	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K05K4_04500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K05K4_04510	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K05K4_04520	COG0772	Belongs to the SEDS family
K05K4_04550	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K05K4_04560	COG0849	cell division
K05K4_04570	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K05K4_04580	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K05K4_04600	COG0653	protein targeting
K05K4_04610	COG0494	nUDIX hydrolase
K05K4_04630	COG0505	Belongs to the CarA family
K05K4_04640	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K05K4_04670	COG0730	response to heat
K05K4_04680	COG0583	DNA-binding transcription factor activity
K05K4_04690	COG2860	membrane
K05K4_04720	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K05K4_04740	COG0493	'glutamate synthase
K05K4_04750	COG0069	glutamate synthase activity
K05K4_04750	COG0070	glutamate synthase
K05K4_04750	COG0067	glutamate synthase
K05K4_04770	COG0070	glutamate synthase
K05K4_04770	COG0069	glutamate synthase activity
K05K4_04770	COG0067	glutamate synthase
K05K4_04780	COG1242	4 iron, 4 sulfur cluster binding
K05K4_04790	COG3706	GGDEF domain
K05K4_04790	COG2203	Gaf domain
K05K4_04790	COG5001	Diguanylate cyclase
K05K4_04790	COG4251	negative regulation of phosphorylation
K05K4_04800	COG2198	Histidine kinase
K05K4_04800	COG0784	Response regulator, receiver
K05K4_04800	COG5002	protein histidine kinase activity
K05K4_04820	COG0745	RESPONSE REGULATOR receiver
K05K4_04840	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K05K4_04870	COG0083	homoserine kinase activity
K05K4_04880	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K05K4_04900	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
K05K4_04910	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K05K4_04960	COG1115	amino acid carrier protein
K05K4_04970	COG3022	response to hydroperoxide
K05K4_04980	COG0513	Belongs to the DEAD box helicase family
K05K4_04990	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K05K4_05010	COG0716	FMN binding
K05K4_05030	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K05K4_05040	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K05K4_05050	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K05K4_05070	COG2204	response regulator
K05K4_05100	COG0667	Aldo Keto reductase
K05K4_05150	COG0730	response to heat
K05K4_05170	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K05K4_05190	COG1283	sodium-dependent phosphate transmembrane transporter activity
K05K4_05200	COG0583	DNA-binding transcription factor activity
K05K4_05210	COG0640	Transcriptional regulator
K05K4_05220	COG0268	Binds directly to 16S ribosomal RNA
K05K4_05230	COG0728	peptidoglycan biosynthetic process
K05K4_05240	COG0196	riboflavin kinase activity
K05K4_05270	COG1047	Peptidyl-prolyl cis-trans
K05K4_05280	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K05K4_05300	COG3279	Response regulator of the LytR AlgR family
K05K4_05310	COG3275	phosphorelay sensor kinase activity
K05K4_05320	COG1966	Carbon starvation protein
K05K4_05360	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K05K4_05370	COG1472	Belongs to the glycosyl hydrolase 3 family
K05K4_05380	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K05K4_05390	COG1605	Chorismate mutase
K05K4_05390	COG0287	Prephenate dehydrogenase
K05K4_05400	COG0739	heme binding
K05K4_05420	COG0488	(ABC) transporter
K05K4_05440	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
K05K4_05450	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
K05K4_05460	COG1605	Chorismate mutase
K05K4_05460	COG0077	Prephenate dehydratase
K05K4_05470	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K05K4_05490	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K05K4_05500	COG0564	pseudouridine synthase activity
K05K4_05520	COG0542	response to heat
K05K4_05650	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K05K4_05670	COG2974	May be involved in recombination
K05K4_05680	COG0745	RESPONSE REGULATOR receiver
K05K4_05690	COG5002	protein histidine kinase activity
K05K4_05710	COG0248	Ppx GppA phosphatase
K05K4_05720	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K05K4_05730	COG0573	inorganic phosphate transmembrane transporter activity
K05K4_05750	COG0581	inorganic phosphate transmembrane transporter activity
K05K4_05760	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K05K4_05770	COG0704	Plays a role in the regulation of phosphate uptake
K05K4_05790	COG3142	Participates in the control of copper homeostasis
K05K4_05800	COG0450	alkyl hydroperoxide reductase
K05K4_05810	COG0583	DNA-binding transcription factor activity
K05K4_05820	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K05K4_05840	COG0517	IMP dehydrogenase activity
K05K4_05860	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K05K4_05880	COG1862	Preprotein translocase
K05K4_05890	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K05K4_05900	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K05K4_05930	COG0483	inositol monophosphate 1-phosphatase activity
K05K4_05940	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
K05K4_05960	COG1104	cysteine desulfurase activity
K05K4_05970	COG0822	iron-sulfur transferase activity
K05K4_06000	COG0443	Heat shock 70 kDa protein
K05K4_06010	COG0633	Ferredoxin
K05K4_06020	COG2975	iron-sulfur cluster assembly
K05K4_06040	COG0105	UTP biosynthetic process
K05K4_06070	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K05K4_06080	COG0124	histidyl-tRNA synthetase
K05K4_06090	COG2976	Protein conserved in bacteria
K05K4_06100	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K05K4_06110	COG1160	GTP binding
K05K4_06150	COG0516	GMP reductase activity
K05K4_06150	COG0517	IMP dehydrogenase activity
K05K4_06170	COG0582	viral genome integration into host DNA
K05K4_06310	COG1757	Na H antiporter
K05K4_06330	COG1584	GPR1 FUN34 yaaH family protein
K05K4_06340	COG1115	amino acid carrier protein
K05K4_06370	COG2873	o-acetylhomoserine
K05K4_06380	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K05K4_06420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K05K4_06420	COG3153	acetyltransferase
K05K4_06430	COG0583	DNA-binding transcription factor activity
K05K4_06470	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K05K4_06480	COG2867	negative regulation of translational initiation
K05K4_06490	COG2914	Belongs to the UPF0125 (RnfH) family
K05K4_06500	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K05K4_06520	COG0497	DNA recombination
K05K4_06540	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K05K4_06550	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K05K4_06570	COG1301	dicarboxylic acid transport
K05K4_06590	COG0484	heat shock protein binding
K05K4_06650	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K05K4_06660	COG0590	tRNA wobble adenosine to inosine editing
K05K4_06670	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K05K4_06680	COG0047	phosphoribosylformylglycinamidine synthase activity
K05K4_06680	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K05K4_06740	COG2195	Cleaves the N-terminal amino acid of tripeptides
K05K4_06750	COG2252	PERMEase
K05K4_06760	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K05K4_06790	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K05K4_06800	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K05K4_06810	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K05K4_06820	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K05K4_06820	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K05K4_06870	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K05K4_06880	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K05K4_06890	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K05K4_06900	COG0142	geranyltranstransferase activity
K05K4_06910	COG1722	exodeoxyribonuclease VII activity
K05K4_06920	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K05K4_06940	COG0301	tRNA thio-modification
K05K4_06940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K05K4_06950	COG0583	DNA-binding transcription factor activity
K05K4_06970	COG2363	Small membrane protein
K05K4_06990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K05K4_07000	COG1611	Belongs to the LOG family
K05K4_07010	COG3706	GGDEF domain
K05K4_07010	COG0745	RESPONSE REGULATOR receiver
K05K4_07030	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K05K4_07030	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K05K4_07050	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
K05K4_07060	COG1464	Belongs to the NlpA lipoprotein family
K05K4_07070	COG2011	ABC-type metal ion transport system permease component
K05K4_07080	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K05K4_07090	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K05K4_07110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K05K4_07110	COG1263	PTS System
K05K4_07120	COG0366	Alpha amylase catalytic
K05K4_07150	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K05K4_07160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K05K4_07170	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K05K4_07180	COG0321	lipoyl(octanoyl) transferase activity
K05K4_07200	COG1686	Belongs to the peptidase S11 family
K05K4_07210	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K05K4_07220	COG0772	Belongs to the SEDS family
K05K4_07230	COG0768	penicillin binding
K05K4_07240	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K05K4_07250	COG0799	negative regulation of ribosome biogenesis
K05K4_07260	COG1466	dna polymerase III delta subunit
K05K4_07270	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
K05K4_07280	COG0495	leucyl-tRNA aminoacylation
K05K4_07290	COG2888	peptidyl-tyrosine sulfation
K05K4_07300	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K05K4_07310	COG4535	Mg2 and Co2 transporter CorC
K05K4_07320	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K05K4_07330	COG1702	phosphate starvation-inducible protein PhoH
K05K4_07340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K05K4_07350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K05K4_07560	COG0012	GTP binding
K05K4_07570	COG0193	aminoacyl-tRNA hydrolase activity
K05K4_07580	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K05K4_07590	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K05K4_07600	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K05K4_07610	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K05K4_07630	COG2890	protein-(glutamine-N5) methyltransferase activity
K05K4_07640	COG3094	Invasion gene expression up-regulator, SirB
K05K4_07650	COG2912	Transglutaminase-like superfamily
K05K4_07660	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K05K4_07670	COG0737	Belongs to the 5'-nucleotidase family
K05K4_07680	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K05K4_07690	COG1187	pseudouridine synthase activity
K05K4_07700	COG2840	Smr protein MutS2
K05K4_07780	COG2608	mercury ion transmembrane transporter activity
K05K4_07780	COG2217	Heavy metal translocating P-type atpase
K05K4_07800	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K05K4_07910	COG0835	chemotaxis
K05K4_07910	COG0784	Response regulator, receiver
K05K4_07920	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K05K4_07930	COG1815	bacterial-type flagellum-dependent cell motility
K05K4_07940	COG1558	bacterial-type flagellum-dependent cell motility
K05K4_07950	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K05K4_07960	COG1749	Flagellar hook protein flgE
K05K4_07970	COG4787	bacterial-type flagellum-dependent cell motility
K05K4_07980	COG4786	Flagellar basal body rod
K05K4_07990	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K05K4_08000	COG1706	bacterial-type flagellum-dependent cell motility
K05K4_08010	COG1705	Flagellar rod assembly protein muramidase FlgJ
K05K4_08010	COG3951	Flagellar rod assembly protein muramidase FlgJ
K05K4_08030	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K05K4_08040	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K05K4_08050	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K05K4_08060	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K05K4_08070	COG2190	(PTS) system
K05K4_08080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K05K4_08100	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K05K4_08110	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K05K4_08120	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
K05K4_08130	COG3115	cell septum assembly
K05K4_08140	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K05K4_08190	COG0330	HflC and HflK could
K05K4_08200	COG2194	sulfuric ester hydrolase activity
K05K4_08240	COG1192	Involved in chromosome partitioning
K05K4_08250	COG1215	transferase activity, transferring glycosyl groups
K05K4_08270	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
K05K4_08280	COG0457	Tetratricopeptide repeat
K05K4_08280	COG3118	belongs to the thioredoxin family
K05K4_08290	COG3118	belongs to the thioredoxin family
K05K4_08300	COG0300	oxidoreductase activity
K05K4_08310	COG1090	epimerase
K05K4_08370	COG0622	Phosphoesterase
K05K4_08410	COG3710	Transcriptional regulator
K05K4_08420	COG0326	Molecular chaperone. Has ATPase activity
K05K4_08440	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K05K4_08450	COG3104	oligopeptide transport
K05K4_08460	COG0250	Participates in transcription elongation, termination and antitermination
K05K4_08470	COG0367	asparagine synthase
K05K4_08480	COG4651	solute:proton antiporter activity
K05K4_08480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K05K4_08490	COG1940	carbohydrate kinase activity
K05K4_08490	COG1846	Transcriptional regulator
K05K4_08500	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K05K4_08510	COG2190	(PTS) system
K05K4_08510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K05K4_08510	COG1263	PTS System
K05K4_08520	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K05K4_08530	COG0735	belongs to the Fur family
K05K4_08550	COG0716	FMN binding
K05K4_08570	COG0596	Alpha beta hydrolase
K05K4_08580	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
K05K4_08590	COG0033	Phosphoglucomutase
K05K4_08610	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K05K4_08630	COG2009	succinate dehydrogenase
K05K4_08640	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K05K4_08650	COG1053	succinate dehydrogenase
K05K4_08660	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K05K4_08670	COG0567	Dehydrogenase, E1 component
K05K4_08680	COG0508	dehydrogenase complex catalyzes the overall conversion of
K05K4_08690	COG0045	succinate-CoA ligase (ADP-forming) activity
K05K4_08710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K05K4_08720	COG1121	(ABC) transporter
K05K4_08730	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
K05K4_08740	COG4977	sequence-specific DNA binding
K05K4_08750	COG1918	ferrous iron import across plasma membrane
K05K4_08800	COG0018	arginyl-trna synthetase
K05K4_08810	COG3102	Protein conserved in bacteria
K05K4_08840	COG0788	formyltetrahydrofolate deformylase activity
K05K4_08850	COG1199	ATP-dependent helicase activity
K05K4_08860	COG1214	PFAM Peptidase M22, glycoprotease
K05K4_08880	COG3065	identical protein binding
K05K4_08890	COG2267	carboxylic ester hydrolase activity
K05K4_08900	COG0318	PFAM AMP-dependent synthetase and ligase
K05K4_08910	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K05K4_08930	COG2894	cell division
K05K4_08940	COG0850	regulation of cytokinetic process
K05K4_08950	COG3100	YcgL domain-containing protein
K05K4_08960	COG2951	lytic endotransglycosylase activity
K05K4_08980	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K05K4_08990	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K05K4_09010	COG2226	methyltransferase
K05K4_09030	COG1028	Short-chain dehydrogenase reductase Sdr
K05K4_09040	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K05K4_09050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K05K4_09100	COG2986	histidine ammonia-lyase
K05K4_09110	COG1216	Glycosyl transferase, family 2
K05K4_09120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K05K4_09150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K05K4_09160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K05K4_09230	COG0513	Belongs to the DEAD box helicase family
K05K4_09240	COG0569	domain protein
K05K4_09250	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K05K4_09290	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K05K4_09300	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K05K4_09310	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K05K4_09320	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K05K4_09360	COG0544	peptidyl-prolyl cis-trans isomerase activity
K05K4_09380	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K05K4_09390	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K05K4_09400	COG0776	regulation of translation
K05K4_09410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K05K4_09420	COG1555	photosystem II stabilization
K05K4_09450	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K05K4_09460	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K05K4_09470	COG0436	Aminotransferase
K05K4_09480	COG1169	isochorismate synthase
K05K4_09490	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K05K4_09510	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K05K4_09520	COG1441	menaquinone biosynthetic process
K05K4_09550	COG2855	membrane
K05K4_09560	COG0477	Major facilitator Superfamily
K05K4_09650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K05K4_09660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K05K4_09690	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K05K4_09700	COG1522	sequence-specific DNA binding
K05K4_09720	COG1946	Acyl-CoA thioesterase
K05K4_09730	COG3126	Type III secretion system lipoprotein chaperone (YscW)
K05K4_09760	COG3706	GGDEF domain
K05K4_09770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K05K4_09780	COG0516	GMP reductase activity
K05K4_09780	COG0517	IMP dehydrogenase activity
K05K4_09830	COG0537	adenosine 5'-monophosphoramidase activity
K05K4_09880	COG3150	esterase
K05K4_09890	COG1252	NADH dehydrogenase
K05K4_09920	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K05K4_09940	COG4591	ABC-type transport system involved in lipoprotein release permease component
K05K4_09950	COG1136	(ABC) transporter
K05K4_09960	COG4591	ABC-type transport system involved in lipoprotein release permease component
K05K4_09980	COG2333	competence protein COMEC
K05K4_09980	COG0658	competence protein
K05K4_09990	COG1132	(ABC) transporter
K05K4_10030	COG2719	SpoVR family
K05K4_10040	COG2718	Belongs to the UPF0229 family
K05K4_10050	COG2766	serine protein kinase
K05K4_10060	COG3013	Belongs to the UPF0304 family
K05K4_10080	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K05K4_10100	COG1882	Formate acetyltransferase
K05K4_10150	COG4215	(ABC) transporter
K05K4_10180	COG0708	Exodeoxyribonuclease III
K05K4_10200	COG3923	Primosomal replication protein n
K05K4_10210	COG0730	response to heat
K05K4_10220	COG1199	ATP-dependent helicase activity
K05K4_10240	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K05K4_10250	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K05K4_10260	COG1187	pseudouridine synthase activity
K05K4_10280	COG1278	Cold shock
K05K4_10290	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K05K4_10300	COG0542	response to heat
K05K4_10310	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K05K4_10320	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K05K4_10330	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K05K4_10370	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K05K4_10380	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K05K4_10390	COG0297	glycogen (starch) synthase activity
K05K4_10430	COG3070	regulator of competence-specific genes
K05K4_10440	COG1609	Transcriptional regulator
K05K4_10450	COG3381	protein complex oligomerization
K05K4_10460	COG0745	RESPONSE REGULATOR receiver
K05K4_10470	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K05K4_10480	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K05K4_10490	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
K05K4_10500	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
K05K4_10510	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K05K4_10550	COG0189	ligase activity
K05K4_10550	COG4067	protein conserved in archaea
K05K4_10560	COG0500	methyltransferase
K05K4_10580	COG1801	Protein of unknown function DUF72
K05K4_10600	COG0217	transcriptional regulatory protein
K05K4_10610	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K05K4_10620	COG0632	four-way junction helicase activity
K05K4_10630	COG2255	four-way junction helicase activity
K05K4_10640	COG1271	oxidase subunit
K05K4_10650	COG1294	oxidase, subunit
K05K4_10660	COG4890	Cyd operon protein YbgT
K05K4_10680	COG0824	Thioesterase
K05K4_10690	COG0811	peptide transport
K05K4_10720	COG0823	Involved in the tonB-independent uptake of proteins
K05K4_10730	COG2885	chlorophyll binding
K05K4_10740	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
K05K4_10750	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K05K4_10770	COG3766	membrane
K05K4_10790	COG0754	glutathionylspermidine amidase activity
K05K4_10810	COG5002	protein histidine kinase activity
K05K4_10810	COG0784	Response regulator, receiver
K05K4_10850	COG1294	oxidase, subunit
K05K4_10860	COG1271	oxidase subunit
K05K4_10910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K05K4_10920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K05K4_10970	COG3568	Endonuclease Exonuclease Phosphatase
K05K4_11020	COG0583	DNA-binding transcription factor activity
K05K4_11040	COG0686	Belongs to the AlaDH PNT family
K05K4_11060	COG1674	ftsk spoiiie
K05K4_11080	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K05K4_11120	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K05K4_11130	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K05K4_11170	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K05K4_11210	COG0300	oxidoreductase activity
K05K4_11240	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K05K4_11260	COG2268	Band 7 protein
K05K4_11280	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K05K4_11290	COG2915	High frequency lysogenization protein hflD homolog
K05K4_11320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K05K4_11340	COG1757	Na H antiporter
K05K4_11360	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K05K4_11380	COG0131	Imidazoleglycerol-phosphate dehydratase
K05K4_11380	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K05K4_11390	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K05K4_11400	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K05K4_11410	COG0107	imidazoleglycerol-phosphate synthase activity
K05K4_11420	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K05K4_11420	COG0140	phosphoribosyl-ATP diphosphatase activity
K05K4_11430	COG3012	SEC-C Motif Domain Protein
K05K4_11440	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K05K4_11450	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K05K4_11460	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K05K4_11470	COG0215	cysteine-tRNA ligase activity
K05K4_11480	COG1435	thymidine kinase activity
K05K4_11540	COG2116	formate transmembrane transporter activity
K05K4_11560	COG0390	transport system, permease component
K05K4_11570	COG4459	periplasmic nitrate reductase
K05K4_11580	COG3005	denitrification pathway
K05K4_11590	COG0243	molybdopterin cofactor binding
K05K4_11620	COG1227	inorganic diphosphatase activity
K05K4_11640	COG4172	Belongs to the ABC transporter superfamily
K05K4_11660	COG4171	peptide transport system, permease
K05K4_11670	COG4168	peptide transport system, permease
K05K4_11690	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K05K4_11700	COG1842	Phage shock protein A
K05K4_11720	COG1983	PspC domain protein
K05K4_11760	COG2818	Glycosylase
K05K4_11770	COG5380	lipid catabolic process
K05K4_11780	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
K05K4_11790	COG0626	cystathionine gamma-synthase activity
K05K4_11810	COG0733	neurotransmitter:sodium symporter activity
K05K4_11820	COG0564	pseudouridine synthase activity
K05K4_11840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K05K4_11850	COG1151	hydroxylamine reductase activity
K05K4_11860	COG3604	Transcriptional regulator
K05K4_11880	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K05K4_11890	COG4136	ATPase activity
K05K4_11900	COG4135	transport system, permease component
K05K4_11910	COG4134	Bacterial extracellular solute-binding protein
K05K4_11930	COG3313	Fe-S protein
K05K4_11970	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K05K4_11980	COG2205	protein histidine kinase activity
K05K4_11990	COG0745	RESPONSE REGULATOR receiver
K05K4_12010	COG1061	Type III restriction enzyme res subunit
K05K4_12020	COG1187	pseudouridine synthase activity
K05K4_12030	COG2814	Major facilitator Superfamily
K05K4_12050	COG0702	epimerase
K05K4_12060	COG0534	Mate efflux family protein
K05K4_12100	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K05K4_12120	COG1960	acyl-CoA dehydrogenase activity
K05K4_12130	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K05K4_12140	COG3273	potassium ion transport
K05K4_12140	COG2985	domain, Protein
K05K4_12150	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K05K4_12180	COG1737	Transcriptional regulator
K05K4_12190	COG0076	glutamate decarboxylase activity
K05K4_12210	COG2431	L-lysine efflux transmembrane transporter activity
K05K4_12230	COG3070	regulator of competence-specific genes
K05K4_12270	COG4191	Histidine kinase
K05K4_12270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K05K4_12290	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K05K4_12310	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K05K4_12320	COG4988	ABC transporter
K05K4_12330	COG0492	ferredoxin-NADP+ reductase activity
K05K4_12370	COG0745	RESPONSE REGULATOR receiver
K05K4_12370	COG3706	GGDEF domain
K05K4_12380	COG0471	metal ion transport
K05K4_12390	COG2949	membrane
K05K4_12400	COG0281	malic enzyme
K05K4_12410	COG1643	Atp-dependent helicase
K05K4_12440	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K05K4_12510	COG0277	FAD linked oxidase domain protein
K05K4_12510	COG0247	lactate metabolic process
K05K4_12540	COG2986	histidine ammonia-lyase
K05K4_12550	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K05K4_12560	COG0010	Belongs to the arginase family
K05K4_12570	COG1228	amidohydrolase
K05K4_12610	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K05K4_12630	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K05K4_12650	COG0393	Putative heavy-metal-binding
K05K4_12720	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K05K4_12730	COG0072	phenylalanine-tRNA ligase activity
K05K4_12730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K05K4_12750	COG0776	regulation of translation
K05K4_12770	COG0500	methyltransferase
K05K4_12780	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K05K4_12790	COG0295	cytidine deaminase activity
K05K4_12800	COG1346	cytolysis
K05K4_12810	COG1380	Effector of murein hydrolase LrgA
K05K4_12820	COG2925	Exonuclease
K05K4_12940	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K05K4_13000	COG1484	DNA-dependent DNA replication
K05K4_13300	COG0702	epimerase
K05K4_13310	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K05K4_13320	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K05K4_13360	COG2988	succinylglutamate desuccinylase activity
K05K4_13370	COG4139	cobalamin transport
K05K4_13380	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
K05K4_13420	COG0583	DNA-binding transcription factor activity
K05K4_13440	COG1451	nucleotide metabolic process
K05K4_13450	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
K05K4_13510	COG3938	Belongs to the proline racemase family
K05K4_13540	COG2423	ornithine cyclodeaminase activity
K05K4_13550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K05K4_13560	COG3842	ATPase activity
K05K4_13570	COG1176	ABC-type spermidine putrescine transport system, permease component I
K05K4_13580	COG1177	transmembrane transport
K05K4_13600	COG3291	Pkd domain containing protein
K05K4_13630	COG0444	Belongs to the ABC transporter superfamily
K05K4_13640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K05K4_13650	COG0601	transmembrane transport
K05K4_13670	COG2195	Cleaves the N-terminal amino acid of tripeptides
K05K4_13690	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K05K4_13710	COG0625	glutathione transferase activity
K05K4_13810	COG3755	Protein conserved in bacteria
K05K4_13860	COG1742	UPF0060 membrane protein
K05K4_13890	COG1757	Na H antiporter
K05K4_13900	COG0174	glutamine synthetase
K05K4_13910	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K05K4_13920	COG1396	sequence-specific DNA binding
K05K4_13920	COG1917	Cupin 2, conserved barrel domain protein
K05K4_13930	COG1012	belongs to the aldehyde dehydrogenase family
K05K4_13940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K05K4_13960	COG2957	Belongs to the agmatine deiminase family
K05K4_13970	COG1012	belongs to the aldehyde dehydrogenase family
K05K4_13980	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K05K4_13990	COG2200	EAL domain
K05K4_14010	COG1846	Transcriptional regulator
K05K4_14020	COG2315	Protein conserved in bacteria
K05K4_14100	COG3063	Type IV pilus biogenesis stability protein PilW
K05K4_14110	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K05K4_14140	COG1560	Kdo2-lipid A biosynthetic process
K05K4_14160	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K05K4_14410	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K05K4_14420	COG1280	lysine exporter protein (LysE YggA)
K05K4_14440	COG1115	amino acid carrier protein
K05K4_14450	COG1115	amino acid carrier protein
K05K4_14500	COG1368	sulfuric ester hydrolase activity
K05K4_14510	COG2113	Glycine betaine
K05K4_14520	COG4176	ABC-type proline glycine betaine transport system permease component
K05K4_14530	COG4175	Glycine betaine
K05K4_14560	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K05K4_14570	COG0456	acetyltransferase
K05K4_14580	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K05K4_14590	COG0662	Cupin 2, conserved barrel domain protein
K05K4_14600	COG0527	aspartate kinase activity
K05K4_14610	COG3119	arylsulfatase activity
K05K4_14640	COG0641	radical SAM
K05K4_14670	COG3119	arylsulfatase activity
K05K4_14720	COG1538	Outer membrane efflux protein
K05K4_14750	COG1349	DNA-binding transcription factor activity
K05K4_14760	COG0673	inositol 2-dehydrogenase activity
K05K4_14770	COG4702	Belongs to the UPF0303 family
K05K4_14780	COG0745	RESPONSE REGULATOR receiver
K05K4_14780	COG3706	GGDEF domain
K05K4_14820	COG0471	metal ion transport
K05K4_14850	COG5001	Diguanylate cyclase
K05K4_14850	COG3300	MHYT domain
K05K4_14880	COG1328	CTP reductase activity
K05K4_14890	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K05K4_14910	COG0861	Integral membrane protein TerC family
K05K4_14930	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K05K4_14950	COG0814	amino acid
K05K4_14980	COG1120	ATPase activity
K05K4_14990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K05K4_15010	COG4774	siderophore transport
K05K4_15030	COG1132	(ABC) transporter
K05K4_15040	COG1132	(ABC) transporter
K05K4_15070	COG0583	DNA-binding transcription factor activity
K05K4_15120	COG0443	Heat shock 70 kDa protein
K05K4_15130	COG0443	Heat shock 70 kDa protein
K05K4_15230	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K05K4_15240	COG1643	Atp-dependent helicase
K05K4_15270	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K05K4_15290	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K05K4_15300	COG1215	transferase activity, transferring glycosyl groups
K05K4_15310	COG0438	transferase activity, transferring glycosyl groups
K05K4_15370	COG0438	transferase activity, transferring glycosyl groups
K05K4_15380	COG0438	transferase activity, transferring glycosyl groups
K05K4_15390	COG2204	response regulator
K05K4_15460	COG1793	dna ligase
K05K4_15480	COG0534	Mate efflux family protein
K05K4_15490	COG0307	riboflavin synthase, alpha
K05K4_15530	COG3706	GGDEF domain
K05K4_15550	COG0791	NLP P60 protein
K05K4_15630	COG1940	carbohydrate kinase activity
K05K4_15660	COG0746	molybdenum cofactor guanylyltransferase activity
K05K4_15670	COG3842	ATPase activity
K05K4_15700	COG2204	response regulator
K05K4_15710	COG4191	Histidine kinase
K05K4_15720	COG0488	(ABC) transporter
K05K4_15740	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K05K4_15780	COG3381	protein complex oligomerization
K05K4_15800	COG3383	formate dehydrogenase (NAD+) activity
K05K4_15800	COG0243	molybdopterin cofactor binding
K05K4_15810	COG0437	4 iron, 4 sulfur cluster binding
K05K4_15860	COG0004	ammonium transporteR
K05K4_15880	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K05K4_15890	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K05K4_15910	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K05K4_15920	COG1177	transmembrane transport
K05K4_15930	COG1176	ABC-type spermidine putrescine transport system, permease component I
K05K4_15940	COG3842	ATPase activity
K05K4_15990	COG0589	response to stress
K05K4_16000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K05K4_16030	COG2217	Heavy metal translocating P-type atpase
K05K4_16050	COG2010	Cytochrome c
K05K4_16080	COG3278	Belongs to the heme-copper respiratory oxidase family
K05K4_16110	COG2205	protein histidine kinase activity
K05K4_16110	COG0784	Response regulator, receiver
K05K4_16210	COG4128	Pfam Zonular occludens toxin
K05K4_16260	COG3120	sequence-specific DNA binding
K05K4_16270	COG1067	ATP-dependent peptidase activity
K05K4_16280	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K05K4_16330	COG0116	Belongs to the methyltransferase superfamily
K05K4_16330	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K05K4_16350	COG0167	dihydroorotate dehydrogenase activity
K05K4_16360	COG2902	Dehydrogenase
K05K4_16370	COG0308	aminopeptidase N
K05K4_16400	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
K05K4_16410	COG1956	GAF domain-containing protein
K05K4_16420	COG1132	(ABC) transporter
K05K4_16430	COG2995	paraquat-inducible protein a
K05K4_16440	COG3008	intermembrane lipid transfer
K05K4_16490	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K05K4_16500	COG1666	GTP binding
K05K4_16520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K05K4_16540	COG4597	amino acid ABC transporter
K05K4_16550	COG0765	amino acid transport
K05K4_16560	COG1126	abc transporter atp-binding protein
K05K4_16570	COG0670	Belongs to the BI1 family
K05K4_16590	COG2920	part of a sulfur-relay system
K05K4_16600	COG1254	Belongs to the acylphosphatase family
K05K4_16610	COG0840	transmembrane signaling receptor activity
K05K4_16650	COG2885	chlorophyll binding
K05K4_16700	COG2199	diguanylate cyclase activity
K05K4_16700	COG2203	Gaf domain
K05K4_16710	COG1414	Transcriptional regulator
K05K4_16730	COG0656	L-ascorbic acid biosynthetic process
K05K4_16740	COG0583	DNA-binding transcription factor activity
K05K4_16760	COG0583	DNA-binding transcription factor activity
K05K4_16770	COG2814	Major facilitator Superfamily
K05K4_16810	COG1335	isochorismatase
K05K4_16820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K05K4_16850	COG1410	methionine synthase
K05K4_16850	COG0646	methionine synthase
K05K4_16860	COG1126	abc transporter atp-binding protein
K05K4_16870	COG0765	amino acid transport
K05K4_16880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K05K4_16920	COG0583	DNA-binding transcription factor activity
K05K4_16950	COG0583	DNA-binding transcription factor activity
K05K4_16970	COG0583	DNA-binding transcription factor activity
K05K4_17000	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K05K4_17010	COG0602	queuosine metabolic process
K05K4_17020	COG0561	phosphatase activity
K05K4_17070	COG2828	Protein conserved in bacteria
K05K4_17090	COG0372	Belongs to the citrate synthase family
K05K4_17100	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K05K4_17170	COG0730	response to heat
K05K4_17210	COG0457	Tetratricopeptide repeat
K05K4_17340	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K05K4_17350	COG4790	Type iii secretion
K05K4_17360	COG4794	Type iii secretion
K05K4_17370	COG4791	protein targeting
K05K4_17380	COG4792	protein secretion
K05K4_17390	COG2207	Transcriptional regulator
K05K4_17450	COG3177	Filamentation induced by cAMP protein fic
K05K4_17490	COG4669	(LipO)protein
K05K4_17630	COG1012	belongs to the aldehyde dehydrogenase family
K05K4_17640	COG3284	Transcriptional regulator
K05K4_17670	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K05K4_17680	COG0363	glucosamine-6-phosphate deaminase activity
K05K4_17690	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K05K4_17700	COG2207	Transcriptional regulator
K05K4_17720	COG4565	transcriptional regulatory protein
K05K4_17730	COG3290	protein histidine kinase activity
K05K4_17750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K05K4_17810	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K05K4_17830	COG2985	domain, Protein
K05K4_17900	COG2272	Belongs to the type-B carboxylesterase lipase family
K05K4_17930	COG0729	surface antigen
K05K4_17950	COG1280	lysine exporter protein (LysE YggA)
K05K4_17960	COG1280	lysine exporter protein (LysE YggA)
K05K4_17970	COG5507	3-demethylubiquinone-9 3-methyltransferase
K05K4_18010	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K05K4_18030	COG0110	maltose O-acetyltransferase activity
K05K4_18110	COG2801	Transposase and inactivated derivatives
K05K4_18160	COG1683	Conserved Protein
K05K4_18280	COG2801	Transposase and inactivated derivatives
K05K4_18330	COG1403	HNH endonuclease
K05K4_18460	COG4974	Belongs to the 'phage' integrase family
K05K4_18490	COG3706	GGDEF domain
K05K4_18510	COG2985	domain, Protein
K05K4_18520	COG0076	glutamate decarboxylase activity
K05K4_18530	COG0598	Magnesium transport protein CorA
K05K4_18550	COG0387	Pfam Sodium calcium exchanger
K05K4_18560	COG0387	Pfam Sodium calcium exchanger
K05K4_18590	COG1289	transmembrane transporter activity
K05K4_18620	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K05K4_18640	COG2985	domain, Protein
K05K4_18650	COG0025	NhaP-type Na H and K H
K05K4_18670	COG2433	Pfam Transposase IS66
K05K4_18690	COG3302	dmso reductase anchor subunit
K05K4_18700	COG0437	4 iron, 4 sulfur cluster binding
K05K4_18710	COG0243	molybdopterin cofactor binding
K05K4_18730	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K05K4_18730	COG2221	Nitrite and sulphite reductase 4Fe-4S
K05K4_18740	COG0784	Response regulator, receiver
K05K4_18740	COG2205	protein histidine kinase activity
K05K4_18830	COG2204	response regulator
K05K4_18880	COG3477	response to acidic pH
K05K4_18890	COG2200	EAL domain
K05K4_18890	COG2199	diguanylate cyclase activity
K05K4_18890	COG3287	FIST C domain
K05K4_18900	COG2197	response regulator
K05K4_19050	COG1472	Belongs to the glycosyl hydrolase 3 family
K05K4_19070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K05K4_19070	COG2205	protein histidine kinase activity
K05K4_19080	COG2197	response regulator
K05K4_19200	COG1335	isochorismatase
K05K4_19330	COG4628	conserved protein (DUF2132)
K05K4_19390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K05K4_19410	COG3768	UPF0283 membrane protein
K05K4_19420	COG3106	COG3106 Predicted ATPase
K05K4_19450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K05K4_19460	COG0784	Response regulator, receiver
K05K4_19460	COG2205	protein histidine kinase activity
K05K4_19480	COG0494	nUDIX hydrolase
K05K4_19490	COG0814	amino acid
K05K4_19500	COG1760	l-serine dehydratase
K05K4_19510	COG2200	EAL domain
K05K4_19530	COG0720	synthase
K05K4_19540	COG0840	transmembrane signaling receptor activity
K05K4_19550	COG0017	Asparaginyl-tRNA synthetase
K05K4_19570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K05K4_19600	COG1448	Aminotransferase
K05K4_19640	COG0840	transmembrane signaling receptor activity
K05K4_19650	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K05K4_19710	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K05K4_19740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K05K4_19750	COG3108	Peptidase M15
K05K4_19760	COG2989	Protein conserved in bacteria
K05K4_19810	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K05K4_19830	COG4235	cytochrome complex assembly
K05K4_19830	COG3088	subunit of a heme lyase
K05K4_19850	COG1138	Cytochrome C-type biogenesis protein
K05K4_19860	COG3301	Polysulphide reductase, NrfD
K05K4_19870	COG0437	4 iron, 4 sulfur cluster binding
K05K4_19890	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
K05K4_19930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K05K4_19940	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K05K4_19950	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K05K4_20000	COG0019	diaminopimelate decarboxylase activity
K05K4_20080	COG0322	excinuclease ABC activity
K05K4_20090	COG2197	response regulator
K05K4_20100	COG0417	DNA replication proofreading
K05K4_20140	COG1187	pseudouridine synthase activity
K05K4_20160	COG0009	L-threonylcarbamoyladenylate synthase
K05K4_20170	COG0613	PHP domain protein
K05K4_20190	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K05K4_20200	COG0512	Glutamine amidotransferase of anthranilate synthase
K05K4_20220	COG0135	phosphoribosylanthranilate isomerase activity
K05K4_20220	COG0134	indole-3-glycerol-phosphate synthase activity
K05K4_20240	COG0159	tryptophan synthase activity
K05K4_20250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K05K4_20260	COG0318	PFAM AMP-dependent synthetase and ligase
K05K4_20270	COG1301	dicarboxylic acid transport
K05K4_20310	COG2917	probably involved in intracellular septation
K05K4_20320	COG1607	acyl-coa hydrolase
K05K4_20330	COG2350	Protein conserved in bacteria
K05K4_20350	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K05K4_20360	COG0583	DNA-binding transcription factor activity
K05K4_20390	COG5001	Diguanylate cyclase
K05K4_20400	COG1032	radical SAM domain protein
K05K4_20440	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K05K4_20450	COG0463	Glycosyl transferase, family 2
K05K4_20460	COG0745	RESPONSE REGULATOR receiver
K05K4_20470	COG5002	protein histidine kinase activity
K05K4_20470	COG3850	Histidine kinase
K05K4_20530	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K05K4_20570	COG1136	(ABC) transporter
K05K4_20570	COG0577	efflux transmembrane transporter activity
K05K4_20580	COG0577	efflux transmembrane transporter activity
K05K4_20580	COG1136	(ABC) transporter
K05K4_20590	COG1136	(ABC) transporter
K05K4_20590	COG0577	efflux transmembrane transporter activity
K05K4_20610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K05K4_20660	COG3118	belongs to the thioredoxin family
K05K4_20670	COG4232	protein-disulfide reductase activity
K05K4_20740	COG2863	cytochrome
K05K4_20750	COG3258	Cytochrome c
K05K4_20760	COG2995	paraquat-inducible protein a
K05K4_20770	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K05K4_20770	COG3008	intermembrane lipid transfer
K05K4_20810	COG4166	transmembrane transport
K05K4_20830	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K05K4_20840	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
K05K4_20860	COG0539	negative regulation of cytoplasmic translation
K05K4_20870	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K05K4_20880	COG0616	signal peptide processing
K05K4_20890	COG1028	Short-chain dehydrogenase reductase Sdr
K05K4_20920	COG0587	DNA-directed DNA polymerase activity
K05K4_20930	COG0835	chemotaxis
K05K4_20930	COG0784	Response regulator, receiver
K05K4_20940	COG1940	carbohydrate kinase activity
K05K4_20950	COG0469	pyruvate kinase activity
K05K4_20960	COG4667	esterase of the alpha-beta hydrolase superfamily
K05K4_20990	COG0733	neurotransmitter:sodium symporter activity
K05K4_21020	COG1263	PTS System
K05K4_21020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K05K4_21030	COG0084	hydrolase, TatD family'
K05K4_21040	COG0470	DNA polymerase III
K05K4_21050	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K05K4_21060	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K05K4_21120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K05K4_21130	COG0416	fatty acid biosynthetic process
K05K4_21150	COG1399	metal-binding, possibly nucleic acid-binding protein
K05K4_21160	COG0424	maF-like protein
K05K4_21170	COG0564	pseudouridine synthase activity
K05K4_21180	COG1530	ribonuclease E activity
K05K4_21190	COG0659	secondary active sulfate transmembrane transporter activity
K05K4_21200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K05K4_21210	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
K05K4_21230	COG0572	uridine kinase
K05K4_21250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K05K4_21250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K05K4_21290	COG2186	Transcriptional regulator
K05K4_21300	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K05K4_21310	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K05K4_21320	COG3012	SEC-C Motif Domain Protein
K05K4_21320	COG3318	Belongs to the UPF0149 family
K05K4_21330	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K05K4_21340	COG3706	GGDEF domain
K05K4_21350	COG0366	Alpha amylase catalytic
K05K4_21360	COG1122	ATPase activity
K05K4_21370	COG4120	Belongs to the binding-protein-dependent transport system permease family
K05K4_21390	COG3092	negative regulation of chromosome organization
K05K4_21400	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K05K4_21410	COG0857	belongs to the CobB CobQ family
K05K4_21410	COG0280	phosphate acetyltransferase
K05K4_21430	COG0435	Glutathione S-transferase
K05K4_21450	COG0444	Belongs to the ABC transporter superfamily
K05K4_21460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K05K4_21470	COG0601	transmembrane transport
K05K4_21490	COG0314	molybdopterin synthase activity
K05K4_21500	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K05K4_21510	COG0315	cyclic pyranopterin monophosphate synthase activity
K05K4_21520	COG0521	Mo-molybdopterin cofactor biosynthetic process
K05K4_21530	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K05K4_21540	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K05K4_21550	COG2198	Histidine kinase
K05K4_21560	COG2204	response regulator
K05K4_21570	COG0556	nucleotide-excision repair
K05K4_21590	COG1882	Formate acetyltransferase
K05K4_21600	COG4657	Part of a membrane complex involved in electron transport
K05K4_21610	COG2878	Part of a membrane complex involved in electron transport
K05K4_21620	COG4656	Part of a membrane complex involved in electron transport
K05K4_21630	COG4658	electron transport chain
K05K4_21640	COG4659	FMN binding
K05K4_21650	COG4660	Part of a membrane complex involved in electron transport
K05K4_21660	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K05K4_21670	COG0346	lactoylglutathione lyase activity
K05K4_21690	COG2885	chlorophyll binding
K05K4_21700	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K05K4_21710	COG2056	Na+-H+ antiporter family
K05K4_21750	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K05K4_21790	COG1012	belongs to the aldehyde dehydrogenase family
K05K4_21790	COG1454	alcohol dehydrogenase
K05K4_21800	COG2095	MarC family integral membrane protein
K05K4_21810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K05K4_21820	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K05K4_21830	COG1757	Na H antiporter
K05K4_21860	COG3081	Nucleoid-associated protein
K05K4_21870	COG3082	Protein of unknown function (DUF1414)
K05K4_21880	COG3083	sulfuric ester hydrolase activity
K05K4_21900	COG0123	including yeast histone deacetylase and acetoin utilization protein
K05K4_21940	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K05K4_21950	COG0778	Nitroreductase
K05K4_21970	COG0446	pyridine nucleotide-disulphide oxidoreductase
K05K4_21970	COG1902	pentaerythritol trinitrate reductase activity
K05K4_21980	COG0616	signal peptide processing
K05K4_21990	COG0252	asparaginase activity
K05K4_22000	COG3139	Protein of unknown function (DUF1315)
K05K4_22020	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K05K4_22030	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K05K4_22060	COG2226	methyltransferase
K05K4_22090	COG1785	Belongs to the alkaline phosphatase family
K05K4_22110	COG0346	lactoylglutathione lyase activity
K05K4_22120	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
K05K4_22130	COG0668	transmembrane transport
K05K4_22140	COG2983	Belongs to the UPF0260 family
K05K4_22150	COG2261	transglycosylase associated protein
K05K4_22170	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K05K4_22180	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K05K4_22190	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K05K4_22210	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K05K4_22220	COG2832	Protein of unknown function (DUF454)
K05K4_22240	COG0745	RESPONSE REGULATOR receiver
K05K4_22250	COG0583	DNA-binding transcription factor activity
K05K4_22260	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K05K4_22270	COG1286	toxin biosynthetic process
K05K4_22280	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
K05K4_22290	COG0285	dihydrofolate synthase activity
K05K4_22300	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K05K4_22310	COG0101	tRNA pseudouridine synthase activity
K05K4_22330	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K05K4_22340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K05K4_22350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K05K4_22360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K05K4_22360	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K05K4_22370	COG0431	NADPH-dependent FMN reductase
K05K4_22390	COG3101	peptidyl-lysine hydroxylation
K05K4_22400	COG2860	membrane
K05K4_22410	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K05K4_22420	COG2890	protein-(glutamine-N5) methyltransferase activity
K05K4_22430	COG2840	Smr protein MutS2
K05K4_22440	COG2062	phosphohistidine phosphatase, SixA
K05K4_22470	COG1250	3-hydroxyacyl-CoA dehydrogenase
K05K4_22470	COG1024	Enoyl-CoA hydratase
K05K4_22480	COG0183	Belongs to the thiolase family
K05K4_22530	COG2067	long-chain fatty acid transport protein
K05K4_22550	COG3088	subunit of a heme lyase
K05K4_22550	COG4235	cytochrome complex assembly
K05K4_22570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K05K4_22580	COG1138	Cytochrome C-type biogenesis protein
K05K4_22590	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K05K4_22600	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K05K4_22610	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K05K4_22620	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K05K4_22630	COG4133	protoheme IX ABC transporter activity
K05K4_22650	COG0835	chemotaxis
K05K4_22670	COG1192	Involved in chromosome partitioning
K05K4_22680	COG2201	protein-glutamate methylesterase activity
K05K4_22690	COG2198	Histidine kinase
K05K4_22690	COG0643	Histidine kinase
K05K4_22700	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
K05K4_22730	COG0455	bacterial-type flagellum organization
K05K4_22780	COG1684	flagellar biosynthetic protein fliR
K05K4_22790	COG1987	bacterial-type flagellum assembly
K05K4_22900	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K05K4_22920	COG1677	Flagellar hook-basal body complex protein FliE
K05K4_22930	COG2204	response regulator
K05K4_22940	COG4191	Histidine kinase
K05K4_22950	COG2204	response regulator
K05K4_22960	COG1516	flagellar protein fliS
K05K4_22980	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K05K4_22990	COG1334	flagellar protein FlaG
K05K4_23000	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K05K4_23010	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K05K4_23020	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K05K4_23030	COG2837	iron assimilation
K05K4_23080	COG1393	Belongs to the ArsC family
K05K4_23090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K05K4_23130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K05K4_23150	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K05K4_23200	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K05K4_23220	COG1053	succinate dehydrogenase
K05K4_23350	COG0210	DNA helicase
K05K4_23390	COG2963	transposase activity
K05K4_23420	COG1278	Cold shock
K05K4_23470	COG1278	Cold shock
K05K4_23480	COG4974	Belongs to the 'phage' integrase family
K05K4_23490	COG0330	HflC and HflK could
K05K4_23530	COG1278	Cold shock
K05K4_23560	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K05K4_23590	COG4783	chaperone-mediated protein folding
K05K4_23600	COG1393	Belongs to the ArsC family
K05K4_23640	COG2233	PERMEase
K05K4_23650	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K05K4_23660	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K05K4_23670	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K05K4_23690	COG0121	glutamine amidotransferase
K05K4_23700	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K05K4_23710	COG1960	acyl-CoA dehydrogenase activity
K05K4_23770	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K05K4_23780	COG0328	RNA-DNA hybrid ribonuclease activity
K05K4_23790	COG2226	methyltransferase
K05K4_23800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K05K4_23810	COG1388	LysM domain
K05K4_23810	COG0741	lytic transglycosylase activity
K05K4_23830	COG3021	interspecies interaction between organisms
K05K4_23840	COG0347	Belongs to the P(II) protein family
K05K4_23870	COG0825	malonyl-CoA metabolic process
K05K4_23880	COG0587	DNA-directed DNA polymerase activity
K05K4_23900	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K05K4_23910	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K05K4_23930	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K05K4_23940	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
K05K4_23960	COG0750	zinc metalloprotease
K05K4_23970	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K05K4_23980	COG0575	Belongs to the CDS family
K05K4_23990	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K05K4_24000	COG0233	cytoplasmic translational termination
K05K4_24010	COG0528	UMP kinase activity
K05K4_24020	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K05K4_24030	COG0052	Belongs to the universal ribosomal protein uS2 family
K05K4_24040	COG0024	Methionine aminopeptidase
K05K4_24050	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K05K4_24070	COG0564	pseudouridine synthase activity
K05K4_24080	COG3098	single-species biofilm formation
K05K4_24140	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K05K4_24150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K05K4_24200	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K05K4_24210	COG0254	rRNA binding
K05K4_24220	COG1720	tRNA m6t6A37 methyltransferase activity
K05K4_24230	COG0442	prolyl-tRNA aminoacylation
K05K4_24270	COG0733	neurotransmitter:sodium symporter activity
K05K4_24300	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K05K4_24310	COG0514	ATP-dependent DNA helicase (RecQ)
K05K4_24360	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K05K4_24520	COG0659	secondary active sulfate transmembrane transporter activity
K05K4_24530	COG0589	response to stress
K05K4_24540	COG0519	Catalyzes the synthesis of GMP from XMP
K05K4_24640	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K05K4_24660	COG0745	RESPONSE REGULATOR receiver
K05K4_24660	COG3706	GGDEF domain
K05K4_24680	COG1477	protein flavinylation
K05K4_24690	COG2871	sodium ion transport
K05K4_24700	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K05K4_24710	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K05K4_24720	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K05K4_24730	COG1805	sodium ion transport
K05K4_24740	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K05K4_24750	COG0271	Belongs to the BolA IbaG family
K05K4_24760	COG2813	Specifically methylates the guanine in position
K05K4_24770	COG3056	Lipoprotein
K05K4_24810	COG1595	DNA-templated transcription, initiation
K05K4_24850	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K05K4_24860	COG0693	protein deglycase activity
K05K4_24870	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K05K4_24880	COG3706	GGDEF domain
K05K4_24890	COG2166	iron-sulfur cluster assembly
K05K4_24900	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K05K4_24910	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
K05K4_24930	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K05K4_24930	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K05K4_24950	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K05K4_24960	COG1074	ATP-dependent DNA helicase activity
K05K4_24970	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K05K4_25070	COG0270	DNA (cytosine-5-)-methyltransferase activity
K05K4_25120	COG3141	response to X-ray
K05K4_25150	COG2171	N-acyltransferase activity
K05K4_25160	COG0584	glycerophosphoryl diester phosphodiesterase
K05K4_25170	COG2271	Major facilitator Superfamily
K05K4_25180	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K05K4_25190	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K05K4_25200	COG1349	DNA-binding transcription factor activity
K05K4_25210	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K05K4_25220	COG0598	Magnesium transport protein CorA
K05K4_25260	COG1609	Transcriptional regulator
K05K4_25270	COG0583	DNA-binding transcription factor activity
K05K4_25350	COG1022	Amp-dependent synthetase and ligase
K05K4_25370	COG0583	DNA-binding transcription factor activity
K05K4_25380	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K05K4_25390	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K05K4_25410	COG0560	Phosphoserine phosphatase
K05K4_25430	COG0813	purine-nucleoside phosphorylase activity
K05K4_25440	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K05K4_25450	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K05K4_25460	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K05K4_25470	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K05K4_25480	COG0084	hydrolase, TatD family'
K05K4_25540	COG3153	acetyltransferase
K05K4_25590	COG0534	Mate efflux family protein
K05K4_25620	COG1185	polyribonucleotide nucleotidyltransferase activity
K05K4_25630	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K05K4_25640	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K05K4_25650	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K05K4_25660	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K05K4_25670	COG0195	Participates in both transcription termination and antitermination
K05K4_25680	COG0779	Required for maturation of 30S ribosomal subunits
K05K4_25710	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K05K4_25720	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K05K4_25730	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K05K4_25740	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K05K4_25750	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K05K4_25760	COG1534	Rna-binding protein
K05K4_25770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K05K4_25780	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K05K4_25790	COG2027	D-alanyl-D-alanine carboxypeptidase
K05K4_25810	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K05K4_25820	COG0739	heme binding
K05K4_25870	COG0628	permease
K05K4_25900	COG0747	negative chemotaxis
K05K4_25920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K05K4_25930	COG0444	Belongs to the ABC transporter superfamily
K05K4_25940	COG4608	Belongs to the ABC transporter superfamily
K05K4_25960	COG2971	BadF BadG BcrA BcrD
K05K4_25990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K05K4_26000	COG3842	ATPase activity
K05K4_26020	COG1840	ABC-type Fe3 transport system, periplasmic component
K05K4_26030	COG0004	ammonium transporteR
K05K4_26050	COG3112	Uncharacterised protein family (UPF0231)
K05K4_26060	COG1049	propionate catabolic process, 2-methylcitrate cycle
K05K4_26070	COG1752	Esterase of the alpha-beta hydrolase superfamily
K05K4_26080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K05K4_26090	COG1643	Atp-dependent helicase
K05K4_26100	COG1489	DNA binding
K05K4_26110	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K05K4_26120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K05K4_26140	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K05K4_26150	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K05K4_26160	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K05K4_26170	COG1560	Kdo2-lipid A biosynthetic process
K05K4_26180	COG0842	Transport permease protein
K05K4_26190	COG1131	(ABC) transporter
K05K4_26200	COG0659	secondary active sulfate transmembrane transporter activity
K05K4_26210	COG0288	reversible hydration of carbon dioxide
K05K4_26240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K05K4_26250	COG0508	dehydrogenase complex catalyzes the overall conversion of
K05K4_26260	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K05K4_26270	COG2186	Transcriptional regulator
K05K4_26290	COG0157	Belongs to the NadC ModD family
K05K4_26300	COG4969	Belongs to the N-Me-Phe pilin family
K05K4_26310	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K05K4_26320	COG1459	type II secretion system
K05K4_26340	COG0237	dephospho-CoA kinase activity
K05K4_26350	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
K05K4_26360	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K05K4_26390	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K05K4_26400	COG0228	four-way junction DNA binding
K05K4_26410	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K05K4_26420	COG4137	Cytochrome C assembly protein
K05K4_26430	COG4536	flavin adenine dinucleotide binding
K05K4_26440	COG1854	S-ribosylhomocysteine lyase activity
K05K4_26470	COG0612	Peptidase, M16
K05K4_26480	COG1238	metal cluster binding
K05K4_26500	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K05K4_26510	COG0511	ligase activity, forming carbon-carbon bonds
K05K4_26510	COG5016	pyruvate
K05K4_26640	COG0527	aspartate kinase activity
K05K4_26650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K05K4_26660	COG2137	regulation of response to DNA damage stimulus
K05K4_26670	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K05K4_26680	COG1546	Belongs to the CinA family
K05K4_26690	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K05K4_26700	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K05K4_26720	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K05K4_26730	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K05K4_26750	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K05K4_26760	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K05K4_26770	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K05K4_26780	COG0148	phosphopyruvate hydratase activity
K05K4_26790	COG0504	CTP synthase activity
K05K4_26800	COG3956	TIGRFAM MazG family protein
K05K4_26820	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K05K4_26830	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K05K4_26850	COG0736	holo-[acyl-carrier-protein] synthase activity
K05K4_26860	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K05K4_26870	COG1381	Involved in DNA repair and RecF pathway recombination
K05K4_26880	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K05K4_26900	COG0681	Belongs to the peptidase S26 family
K05K4_26910	COG0481	GTPase activity
K05K4_26920	COG3086	response to oxidative stress
K05K4_26950	COG1595	DNA-templated transcription, initiation
K05K4_26960	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K05K4_26980	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K05K4_27020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K05K4_27030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K05K4_27040	COG3079	Belongs to the UPF0149 family
K05K4_27050	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K05K4_27060	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K05K4_27070	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K05K4_27080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K05K4_27100	COG0583	DNA-binding transcription factor activity
K05K4_27130	COG0668	transmembrane transport
K05K4_27140	COG0191	fructose-bisphosphate aldolase activity
K05K4_27170	COG4771	TonB-dependent receptor
K05K4_27180	COG0583	DNA-binding transcription factor activity
K05K4_27190	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K05K4_27200	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K05K4_27220	COG3091	SprT-like family
K05K4_27230	COG2356	endonuclease I
K05K4_27240	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K05K4_27250	COG0189	ligase activity
K05K4_27260	COG1678	Uncharacterized ACR, COG1678
K05K4_27270	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K05K4_27300	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K05K4_27310	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K05K4_27320	COG0762	integral membrane protein
K05K4_27330	COG1872	DUF167
K05K4_27350	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K05K4_27360	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K05K4_27370	COG2066	Belongs to the glutaminase family
K05K4_27390	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K05K4_27410	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
K05K4_27500	COG0840	transmembrane signaling receptor activity
K05K4_27650	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K05K4_27670	COG3394	polysaccharide catabolic process
K05K4_27680	COG1486	melibiose metabolic process
K05K4_27690	COG1447	Phosphotransferase system cellobiose-specific component IIA
K05K4_27700	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K05K4_27720	COG0726	polysaccharide deacetylase
K05K4_27740	COG1028	Short-chain dehydrogenase reductase Sdr
K05K4_27750	COG4325	translation initiation factor activity
K05K4_27770	COG0795	lipopolysaccharide-transporting ATPase activity
K05K4_27780	COG0795	lipopolysaccharide-transporting ATPase activity
K05K4_27790	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K05K4_27800	COG2927	DNA polymerase III (CHI subunit)
K05K4_27810	COG0525	valine-tRNA ligase activity
K05K4_27830	COG0456	acetyltransferase
K05K4_27890	COG0540	Belongs to the ATCase OTCase family
K05K4_27900	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K05K4_27910	COG0251	oxidation-reduction process
K05K4_27920	COG0204	Acyl-transferase
K05K4_27930	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K05K4_27940	COG5007	Belongs to the BolA IbaG family
K05K4_27960	COG2854	intermembrane phospholipid transfer
K05K4_27970	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K05K4_27980	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K05K4_27990	COG1127	ABC transporter
K05K4_28010	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K05K4_28010	COG0517	IMP dehydrogenase activity
K05K4_28030	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K05K4_28040	COG1137	ATPase activity
K05K4_28060	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K05K4_28070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K05K4_28080	COG1660	Displays ATPase and GTPase activities
K05K4_28090	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K05K4_28100	COG2239	Acts as a magnesium transporter
K05K4_28110	COG0312	modulator of DNA gyrase
K05K4_28120	COG3028	Belongs to the UPF0307 family
K05K4_28130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K05K4_28140	COG0564	pseudouridine synthase activity
K05K4_28160	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K05K4_28170	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K05K4_28180	COG0312	modulator of DNA gyrase
K05K4_28190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K05K4_28200	COG3164	Protein of unknown function
K05K4_28210	COG1530	ribonuclease E activity
K05K4_28220	COG0424	maF-like protein
K05K4_28230	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K05K4_28240	COG1792	Involved in formation and maintenance of cell shape
K05K4_28250	COG1077	Cell shape determining protein MreB Mrl
K05K4_28340	COG1459	type II secretion system
K05K4_28350	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K05K4_28370	COG3267	Type II secretory pathway component ExeA
K05K4_28370	COG3409	Peptidoglycan-binding domain 1 protein
K05K4_28380	COG1450	Type ii and iii secretion system protein
K05K4_28420	COG2199	diguanylate cyclase activity
K05K4_28420	COG2200	EAL domain
K05K4_28430	COG0629	single-stranded DNA binding
K05K4_28460	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K05K4_28500	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K05K4_28510	COG0527	aspartate kinase activity
K05K4_28520	COG0646	methionine synthase
K05K4_28520	COG1410	methionine synthase
K05K4_28650	COG0175	sulfate reduction
K05K4_28660	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K05K4_28670	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K05K4_28710	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K05K4_28720	COG0735	belongs to the Fur family
K05K4_28740	COG0166	Belongs to the GPI family
K05K4_28750	COG0432	Pfam Uncharacterised protein family UPF0047
K05K4_28760	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K05K4_28770	COG0305	Participates in initiation and elongation during chromosome replication
K05K4_28810	COG2965	DNA replication, synthesis of RNA primer
K05K4_28820	COG0360	Binds together with S18 to 16S ribosomal RNA
K05K4_28830	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K05K4_28840	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K05K4_28860	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K05K4_28870	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K05K4_28930	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K05K4_28950	COG0678	peroxiredoxin activity
K05K4_28950	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K05K4_28960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K05K4_28990	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K05K4_28990	COG0165	Argininosuccinate lyase
K05K4_29000	COG0137	argininosuccinate synthase activity
K05K4_29020	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K05K4_29040	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K05K4_29060	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K05K4_29070	COG0527	aspartate kinase activity
K05K4_29070	COG0460	homoserine dehydrogenase
K05K4_29080	COG0626	cystathionine gamma-synthase activity
K05K4_29100	COG0281	malic enzyme
K05K4_29120	COG2906	2 iron, 2 sulfur cluster binding
K05K4_29130	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K05K4_29140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K05K4_29180	COG2923	Belongs to the DsrF TusC family
K05K4_29190	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
K05K4_29200	COG2964	Protein conserved in bacteria
K05K4_29210	COG0545	Peptidyl-prolyl cis-trans isomerase
K05K4_29240	COG1446	asparaginase
K05K4_29250	COG1047	Peptidyl-prolyl cis-trans
K05K4_29280	COG2249	NAD(P)H dehydrogenase (quinone) activity
K05K4_29290	COG0488	(ABC) transporter
K05K4_29310	COG0429	hydrolase of the alpha beta-hydrolase fold
K05K4_29330	COG3954	Phosphoribulokinase
K05K4_29340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K05K4_29380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K05K4_29390	COG0512	Glutamine amidotransferase of anthranilate synthase
K05K4_29420	COG0180	Tryptophanyl-tRNA synthetase
K05K4_29430	COG0546	phosphoglycolate phosphatase activity
K05K4_29440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K05K4_29450	COG0557	exoribonuclease II activity
K05K4_29460	COG1959	2 iron, 2 sulfur cluster binding
K05K4_29470	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K05K4_29470	COG1017	nitric oxide dioxygenase activity
K05K4_29480	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
K05K4_29490	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K05K4_29500	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
K05K4_29510	COG0330	HflC and HflK could
K05K4_29520	COG0330	HflC and HflK could
K05K4_29530	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K05K4_29550	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K05K4_29560	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K05K4_29580	COG0802	atpase or kinase
K05K4_29600	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K05K4_29730	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K05K4_29740	COG1162	GTPase activity
K05K4_29750	COG0688	phosphatidylethanolamine metabolic process
K05K4_29760	COG0471	metal ion transport
K05K4_29780	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K05K4_29790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K05K4_29800	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K05K4_29810	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K05K4_29820	COG1045	serine acetyltransferase
K05K4_29830	COG4942	peptidase
K05K4_29870	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K05K4_29880	COG1053	succinate dehydrogenase
K05K4_29890	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K05K4_29900	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K05K4_29910	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K05K4_29940	COG1509	lysine 2,3-aminomutase activity
K05K4_29950	COG1285	pathogenesis
K05K4_29970	COG0459	protein refolding
K05K4_29980	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K05K4_29990	COG0534	Mate efflux family protein
K05K4_30000	COG0205	6-phosphofructokinase activity
K05K4_30010	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K05K4_30020	COG3678	ATP-independent chaperone mediated protein folding
K05K4_30030	COG0745	RESPONSE REGULATOR receiver
K05K4_30040	COG2205	protein histidine kinase activity
K05K4_30060	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K05K4_30070	COG3030	protein affecting phage T7 exclusion by the F plasmid
K05K4_30080	COG1027	Aspartate ammonia-lyase
K05K4_30090	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K05K4_30100	COG4232	protein-disulfide reductase activity
K05K4_30120	COG3263	regulation of cellular component size
K05K4_30140	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K05K4_30190	COG2814	Major facilitator Superfamily
K05K4_30220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K05K4_30230	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K05K4_30240	COG0511	ligase activity, forming carbon-carbon bonds
K05K4_30250	COG0439	Biotin carboxylase
K05K4_30260	COG2264	protein methyltransferase activity
K05K4_30270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K05K4_30280	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K05K4_30310	COG0488	(ABC) transporter
K05K4_30410	COG1982	Orn Lys Arg decarboxylase major
K05K4_30420	COG0531	amino acid
K05K4_30430	COG3710	Transcriptional regulator
K05K4_30440	COG0789	Transcriptional regulator
K05K4_30460	COG0151	Belongs to the GarS family
K05K4_30490	COG1253	flavin adenine dinucleotide binding
K05K4_30500	COG3068	Protein conserved in bacteria
K05K4_30520	COG1573	uracil-dna glycosylase
K05K4_30530	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K05K4_30540	COG2816	NAD+ diphosphatase activity
K05K4_30550	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
K05K4_30560	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K05K4_30570	COG0085	RNA polymerase activity
K05K4_30580	COG0222	ribosome binding
K05K4_30590	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K05K4_30620	COG0250	Participates in transcription elongation, termination and antitermination
K05K4_30630	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K05K4_30640	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K05K4_30700	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K05K4_30700	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K05K4_30710	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K05K4_30730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K05K4_30900	COG4206	TonB-dependent receptor
K05K4_30940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K05K4_30950	COG0534	Mate efflux family protein
K05K4_30960	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K05K4_30970	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K05K4_30980	COG2937	Belongs to the GPAT DAPAT family
K05K4_30990	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K05K4_31000	COG3161	chorismate lyase activity
K05K4_31010	COG1580	Controls the rotational direction of flagella during chemotaxis
K05K4_31020	COG0705	Rhomboid family
K05K4_31030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K05K4_31050	COG2177	Part of the ABC transporter FtsEX involved in
K05K4_31060	COG2884	Cell division ATP-binding protein ftsE
K05K4_31070	COG0552	protein localization to endoplasmic reticulum
K05K4_31080	COG0742	ribosomal rna small subunit methyltransferase
K05K4_31100	COG2095	MarC family integral membrane protein
K05K4_31180	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K05K4_31190	COG0640	Transcriptional regulator
K05K4_31200	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K05K4_31210	COG1280	lysine exporter protein (LysE YggA)
K05K4_31220	COG2267	carboxylic ester hydrolase activity
K05K4_31230	COG0561	phosphatase activity
K05K4_31270	COG2199	diguanylate cyclase activity
K05K4_31270	COG3287	FIST C domain
K05K4_31270	COG2200	EAL domain
K05K4_31280	COG1011	Hydrolase
K05K4_31290	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K05K4_31320	COG0019	diaminopimelate decarboxylase activity
K05K4_31330	COG1965	Belongs to the frataxin family
K05K4_31340	COG3072	Adenylate cyclase
K05K4_31350	COG0181	hydroxymethylbilane synthase activity
K05K4_31360	COG1587	Uroporphyrinogen-III synthase
K05K4_31370	COG2959	enzyme of heme biosynthesis
K05K4_31380	COG3071	HemY protein
K05K4_31470	COG0633	Ferredoxin
K05K4_31480	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K05K4_31500	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K05K4_31510	COG3118	belongs to the thioredoxin family
K05K4_31520	COG0513	Belongs to the DEAD box helicase family
K05K4_31530	COG0248	Ppx GppA phosphatase
K05K4_31550	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K05K4_31570	COG0514	ATP-dependent DNA helicase (RecQ)
K05K4_31580	COG2962	Rard protein
K05K4_31600	COG1280	lysine exporter protein (LysE YggA)
K05K4_31610	COG0405	Gamma-glutamyltransferase
K05K4_31620	COG0210	DNA helicase
K05K4_31640	COG3220	belongs to the UPF0276 family
K05K4_31700	COG0006	proline dipeptidase activity
K05K4_31700	COG0006	proline dipeptidase activity
K05K4_31730	COG2104	thiamine diphosphate biosynthetic process
K05K4_31740	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K05K4_31780	COG2132	Multicopper oxidase
K05K4_31880	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K05K4_31920	COG0009	L-threonylcarbamoyladenylate synthase
K05K4_31930	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K05K4_31940	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K05K4_31950	COG0551	DNA topoisomerase type I activity
K05K4_31960	COG2922	Belongs to the Smg family
K05K4_31970	COG0758	DNA mediated transformation
K05K4_31990	COG0242	peptide deformylase activity
K05K4_32000	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K05K4_32010	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K05K4_32010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K05K4_32020	COG0569	domain protein
K05K4_32030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K05K4_32050	COG1272	protein, Hemolysin III
K05K4_32060	COG4326	sporulation control protein
K05K4_32080	COG3084	Protein conserved in bacteria
K05K4_32100	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K05K4_32110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K05K4_32120	COG0204	Acyl-transferase
K05K4_32140	COG0606	chelatase, subunit chli
K05K4_32160	COG3978	acetolactate synthase activity
K05K4_32170	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K05K4_32180	COG0129	dihydroxy-acid dehydratase activity
K05K4_32200	COG0583	DNA-binding transcription factor activity
K05K4_32210	COG2814	Major facilitator Superfamily
K05K4_32230	COG0765	amino acid transport
K05K4_32260	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K05K4_32270	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K05K4_32280	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K05K4_32290	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K05K4_32300	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K05K4_32310	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K05K4_32330	COG0356	it plays a direct role in the translocation of protons across the membrane
K05K4_32340	COG3312	ion transport
K05K4_32350	COG1475	DNA binding
K05K4_32360	COG1192	Involved in chromosome partitioning
K05K4_32370	COG0357	Ribosomal RNA small subunit methyltransferase G
K05K4_32380	COG0445	tRNA wobble uridine modification
K05K4_32390	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K05K4_32410	COG0706	membrane insertase activity
K05K4_32420	COG0594	ribonuclease P activity
K05K4_32440	COG1126	abc transporter atp-binding protein
K05K4_32490	COG1444	tRNA N-acetyltransferase activity
K05K4_32530	COG3340	Belongs to the peptidase S51 family
K05K4_32540	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K05K4_32550	COG1263	PTS System
K05K4_32550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K05K4_32560	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K05K4_32590	COG4166	transmembrane transport
K05K4_32690	COG0259	pyridoxamine-phosphate oxidase activity
K05K4_32740	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K05K4_32820	COG1132	(ABC) transporter
K05K4_32840	COG0513	Belongs to the DEAD box helicase family
K05K4_32850	COG2258	MOSC domain
K05K4_32940	COG3634	alkyl hydroperoxide reductase activity
K05K4_32950	COG0450	alkyl hydroperoxide reductase
K05K4_33030	COG1846	Transcriptional regulator
K05K4_33040	COG1764	response to oxidative stress
K05K4_33120	COG1136	(ABC) transporter
K05K4_33170	COG0745	RESPONSE REGULATOR receiver
K05K4_33190	COG1653	transport
K05K4_33200	COG0019	diaminopimelate decarboxylase activity
K05K4_33210	COG4264	IucA IucC family
K05K4_33260	COG4772	TonB-dependent receptor
K05K4_33270	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K05K4_33280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K05K4_33290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K05K4_33300	COG1120	ATPase activity
K05K4_33310	COG0840	transmembrane signaling receptor activity
K05K4_33320	COG0612	Peptidase, M16
K05K4_33340	COG0739	heme binding
K05K4_33370	COG2814	Major facilitator Superfamily
K05K4_33390	COG1609	Transcriptional regulator
K05K4_33400	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K05K4_33450	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K05K4_33460	COG1609	Transcriptional regulator
K05K4_33510	COG0596	Alpha beta hydrolase
K05K4_33560	COG1760	l-serine dehydratase
K05K4_33580	COG4580	involved in the transport of maltose and maltodextrins
K05K4_33620	COG2356	endonuclease I
K05K4_33660	COG1982	Orn Lys Arg decarboxylase major
K05K4_33670	COG0531	amino acid
K05K4_33690	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K05K4_33700	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
K05K4_33710	COG1162	GTPase activity
K05K4_33720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K05K4_33720	COG1263	PTS System
K05K4_33730	COG1999	signal sequence binding
K05K4_33760	COG2909	trisaccharide binding
K05K4_33770	COG0058	SHG alpha-glucan phosphorylase activity
K05K4_33780	COG1640	4-alpha-glucanotransferase
K05K4_33790	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K05K4_33800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K05K4_33810	COG0366	Alpha amylase catalytic
K05K4_33830	COG3366	ferrous iron transmembrane transporter activity
K05K4_33840	COG0700	Nucleoside recognition
K05K4_33850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K05K4_33860	COG3339	Conserved Protein
K05K4_33870	COG1301	dicarboxylic acid transport
K05K4_33890	COG0583	DNA-binding transcription factor activity
K05K4_33940	COG1596	polysaccharide export
K05K4_33970	COG2095	MarC family integral membrane protein
K05K4_33980	COG4667	esterase of the alpha-beta hydrolase superfamily
K05K4_33990	COG3397	chitin binding
K05K4_34000	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K05K4_34010	COG0415	Belongs to the DNA photolyase family
K05K4_34050	COG1686	Belongs to the peptidase S11 family
K05K4_34100	COG0583	DNA-binding transcription factor activity
K05K4_34110	COG4628	conserved protein (DUF2132)
K05K4_34160	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K05K4_34170	COG0628	permease
K05K4_34220	COG1289	transmembrane transporter activity
K05K4_34250	COG2814	Major facilitator Superfamily
K05K4_34270	COG0454	-acetyltransferase
K05K4_34290	COG0745	RESPONSE REGULATOR receiver
K05K4_34300	COG2205	protein histidine kinase activity
K05K4_34330	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K05K4_34340	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K05K4_34420	COG1360	Flagellar Motor Protein
K05K4_34430	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K05K4_34440	COG1191	sigma factor activity
K05K4_34450	COG1580	Controls the rotational direction of flagella during chemotaxis
K05K4_34480	COG1516	flagellar protein fliS
K05K4_34490	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K05K4_34510	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K05K4_34540	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K05K4_34560	COG1987	bacterial-type flagellum assembly
K05K4_34610	COG2204	response regulator
K05K4_34640	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K05K4_34770	COG2204	response regulator
K05K4_34810	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K05K4_34930	COG0346	lactoylglutathione lyase activity
K05K4_34980	COG0745	RESPONSE REGULATOR receiver
K05K4_35030	COG5001	Diguanylate cyclase
K05K4_35030	COG3300	MHYT domain
K05K4_35040	COG0156	8-amino-7-oxononanoate synthase activity
K05K4_35050	COG1063	alcohol dehydrogenase
K05K4_35120	COG0668	transmembrane transport
K05K4_35140	COG1304	FMN binding
K05K4_35150	COG1620	l-lactate permease
K05K4_35160	COG0583	DNA-binding transcription factor activity
K05K4_35170	COG1505	serine-type exopeptidase activity
K05K4_35180	COG4172	Belongs to the ABC transporter superfamily
K05K4_35200	COG1067	ATP-dependent peptidase activity
K05K4_35220	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K05K4_35260	COG1247	-acetyltransferase
K05K4_35270	COG0437	4 iron, 4 sulfur cluster binding
K05K4_35280	COG0348	domain, Protein
K05K4_35320	COG1122	ATPase activity
K05K4_35330	COG4720	Psort location CytoplasmicMembrane, score
K05K4_35340	COG1566	PFAM secretion protein HlyD family protein
K05K4_35360	COG3706	GGDEF domain
K05K4_35390	COG0813	purine-nucleoside phosphorylase activity
K05K4_35400	COG3272	Protein of unknown function (DUF1722)
K05K4_35410	COG0789	Transcriptional regulator
K05K4_35420	COG0415	Belongs to the DNA photolyase family
K05K4_35430	COG1376	ErfK ybiS ycfS ynhG family protein
K05K4_35430	COG1388	LysM domain
K05K4_35450	COG0513	Belongs to the DEAD box helicase family
K05K4_35460	COG1770	oligopeptidase
K05K4_35470	COG4771	TonB-dependent receptor
K05K4_35520	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K05K4_35530	COG0573	inorganic phosphate transmembrane transporter activity
K05K4_35540	COG0581	inorganic phosphate transmembrane transporter activity
K05K4_35550	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K05K4_35580	COG2304	oxidoreductase activity
K05K4_35620	COG0714	Associated with various cellular activities
K05K4_35650	COG2197	response regulator
K05K4_35720	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K05K4_35730	COG1120	ATPase activity
K05K4_35740	COG4774	siderophore transport
K05K4_35750	COG1132	(ABC) transporter
K05K4_35780	COG0569	domain protein
K05K4_35790	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K05K4_35800	COG0583	DNA-binding transcription factor activity
K05K4_35840	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K05K4_35850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K05K4_35870	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
K05K4_35880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K05K4_35940	COG2084	Dehydrogenase
K05K4_35950	COG0753	catalase activity
K05K4_35970	COG2130	NADP-dependent
K05K4_35980	COG1309	transcriptional regulator
K05K4_36070	COG3206	protein involved in exopolysaccharide biosynthesis
K05K4_36070	COG0489	protein tyrosine kinase activity
K05K4_36100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K05K4_36110	COG3842	ATPase activity
K05K4_36130	COG1175	transmembrane transport
K05K4_36140	COG3833	ABC-type maltose transport systems, permease component
K05K4_36200	COG2354	Protein conserved in bacteria
K05K4_36210	COG0418	dihydroorotase activity
K05K4_36220	COG0401	homolog of Blt101
K05K4_36230	COG3217	Mosc domain protein beta barrel domain protein
K05K4_36230	COG0633	Ferredoxin
K05K4_36230	COG3217	Mosc domain protein beta barrel domain protein
K05K4_36230	COG0633	Ferredoxin
K05K4_36250	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K05K4_36330	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K05K4_36340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K05K4_36360	COG0848	biopolymer transport protein
K05K4_36370	COG0811	peptide transport
K05K4_36380	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K05K4_36400	COG3721	Heme iron utilization protein
K05K4_36410	COG0748	coenzyme F420 binding
K05K4_36430	COG0784	Response regulator, receiver
K05K4_36430	COG0835	chemotaxis
K05K4_36440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K05K4_36450	COG0534	Mate efflux family protein
K05K4_36460	COG0444	Belongs to the ABC transporter superfamily
K05K4_36470	COG4608	Belongs to the ABC transporter superfamily
K05K4_36480	COG0747	negative chemotaxis
K05K4_36500	COG1349	DNA-binding transcription factor activity
K05K4_36510	COG2084	Dehydrogenase
K05K4_36520	COG3395	kinase activity
K05K4_36530	COG0235	Class ii aldolase
K05K4_36540	COG3622	Belongs to the hyi family
K05K4_36550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K05K4_36560	COG2610	gluconate transmembrane transporter activity
K05K4_36600	COG0583	DNA-binding transcription factor activity
K05K4_36610	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K05K4_36630	COG4934	collagen metabolic process
K05K4_36650	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K05K4_36660	COG0789	Transcriptional regulator
K05K4_36670	COG0366	Alpha amylase catalytic
K05K4_36710	COG2249	NAD(P)H dehydrogenase (quinone) activity
K05K4_36720	COG0589	response to stress
K05K4_36730	COG0488	(ABC) transporter
K05K4_36740	COG1505	serine-type exopeptidase activity
K05K4_36760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K05K4_36780	COG2067	long-chain fatty acid transport protein
K05K4_36800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K05K4_36850	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K05K4_36890	COG3383	formate dehydrogenase (NAD+) activity
K05K4_36910	COG0842	Transport permease protein
K05K4_36920	COG1131	(ABC) transporter
K05K4_36960	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
K05K4_36980	COG4145	pantothenate transmembrane transporter activity
K05K4_36990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K05K4_37000	COG0800	Aldolase
K05K4_37020	COG2706	6-phosphogluconolactonase activity
K05K4_37030	COG0251	oxidation-reduction process
K05K4_37050	COG1881	PFAM PEBP family protein
K05K4_37070	COG0798	PFAM Bile acid sodium symporter
K05K4_37100	COG1733	regulation of RNA biosynthetic process
K05K4_37160	COG4989	oxidoreductase activity
K05K4_37210	COG0814	amino acid
K05K4_37280	COG0739	heme binding
K05K4_37290	COG5001	Diguanylate cyclase
K05K4_37300	COG0583	DNA-binding transcription factor activity
K05K4_37310	COG2814	Major facilitator Superfamily
K05K4_37350	COG0697	spore germination
K05K4_37380	COG0179	Fumarylacetoacetate (FAA) hydrolase
K05K4_37420	COG1280	lysine exporter protein (LysE YggA)
K05K4_37440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K05K4_37450	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K05K4_37470	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K05K4_37480	COG1845	cytochrome c oxidase, subunit III
K05K4_37510	COG1612	heme a metabolic process
K05K4_37520	COG0109	protoheme IX farnesyltransferase activity
K05K4_37530	COG0545	Peptidyl-prolyl cis-trans isomerase
K05K4_37590	COG1278	Cold shock
K05K4_37600	COG3036	rescue of stalled ribosome
K05K4_37610	COG2199	diguanylate cyclase activity
K05K4_37640	COG1132	(ABC) transporter
K05K4_37650	COG1132	(ABC) transporter
K05K4_37660	COG1538	Outer membrane efflux protein
K05K4_37670	COG0784	Response regulator, receiver
K05K4_37670	COG2205	protein histidine kinase activity
K05K4_37720	COG0840	transmembrane signaling receptor activity
K05K4_37740	COG0783	Belongs to the Dps family
K05K4_37760	COG2133	pyrroloquinoline quinone binding
K05K4_37770	COG1454	alcohol dehydrogenase
K05K4_37780	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
K05K4_37830	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K05K4_37840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K05K4_37850	COG3186	Phenylalanine-4-hydroxylase
K05K4_37900	COG3530	Putative quorum-sensing-regulated virulence factor
K05K4_37940	COG0513	Belongs to the DEAD box helicase family
K05K4_37950	COG4628	conserved protein (DUF2132)
K05K4_37970	COG0133	tryptophan synthase activity
K05K4_37980	COG1278	Cold shock
K05K4_38000	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
K05K4_38020	COG0523	cobalamin synthesis protein
K05K4_38030	COG0513	Belongs to the DEAD box helicase family
K05K4_38070	COG2200	EAL domain
K05K4_38080	COG1119	ATPase activity
K05K4_38120	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K05K4_38150	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
K05K4_38160	COG0513	Belongs to the DEAD box helicase family
K05K4_38170	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K05K4_38190	COG1073	alpha beta
K05K4_38200	COG1073	alpha beta
K05K4_38230	COG0730	response to heat
K05K4_38260	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K05K4_38280	COG0523	cobalamin synthesis protein
K05K4_38290	COG2988	succinylglutamate desuccinylase activity
K05K4_38300	COG0739	heme binding
K05K4_38320	COG0523	cobalamin synthesis protein
K05K4_38340	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K05K4_38350	COG2095	MarC family integral membrane protein
K05K4_38400	COG1024	Enoyl-CoA hydratase
K05K4_38410	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K05K4_38420	COG1960	acyl-CoA dehydrogenase activity
K05K4_38440	COG0183	Belongs to the thiolase family
K05K4_38470	COG1024	Enoyl-CoA hydratase
K05K4_38480	COG1024	Enoyl-CoA hydratase
K05K4_38500	COG1028	Short-chain dehydrogenase reductase Sdr
K05K4_38510	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K05K4_38520	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K05K4_38530	COG1845	cytochrome c oxidase, subunit III
K05K4_38540	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K05K4_38550	COG0109	protoheme IX farnesyltransferase activity
K05K4_38560	COG0446	pyridine nucleotide-disulphide oxidoreductase
K05K4_38560	COG1902	pentaerythritol trinitrate reductase activity
K05K4_38590	COG1012	belongs to the aldehyde dehydrogenase family
K05K4_38610	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K05K4_38670	COG1126	abc transporter atp-binding protein
K05K4_38680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K05K4_38690	COG4215	(ABC) transporter
K05K4_38700	COG4160	amino acid transport
K05K4_38840	COG0443	Heat shock 70 kDa protein
K05K4_38850	COG2847	Copper chaperone PCu(A)C
K05K4_38960	COG3706	GGDEF domain
K05K4_38980	COG0814	amino acid
K05K4_39000	COG0243	molybdopterin cofactor binding
K05K4_39040	COG3707	response regulator
K05K4_39050	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K05K4_39050	COG1116	anion transmembrane transporter activity
K05K4_39060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K05K4_39070	COG1116	anion transmembrane transporter activity
K05K4_39080	COG2146	nitrite reductase [NAD(P)H] activity
K05K4_39080	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K05K4_39180	COG2815	serine threonine protein kinase
K05K4_39180	COG0515	serine threonine protein kinase
K05K4_39250	COG0631	protein serine/threonine phosphatase activity
K05K4_39360	COG3501	Rhs element vgr protein
K05K4_39390	COG0420	3'-5' exonuclease activity
K05K4_39400	COG0419	ATPase involved in DNA repair
K05K4_39420	COG3040	lipid binding
K05K4_39440	COG1288	antiporter activity
K05K4_39460	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
K05K4_39490	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K05K4_39520	COG0583	DNA-binding transcription factor activity
K05K4_39530	COG0277	FAD linked oxidase domain protein
K05K4_39560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K05K4_39630	COG2176	DNA-directed DNA polymerase activity
K05K4_39720	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
K05K4_39730	COG1328	CTP reductase activity
K05K4_40180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K05K4_40220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K05K4_40240	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K05K4_40250	COG2146	nitrite reductase [NAD(P)H] activity
K05K4_40260	COG2116	formate transmembrane transporter activity
K05K4_40300	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K05K4_40360	COG2814	Major facilitator Superfamily
K05K4_40370	COG3118	belongs to the thioredoxin family
K05K4_40380	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K05K4_40430	COG2271	Major facilitator Superfamily
K05K4_40440	COG3851	Histidine kinase
K05K4_40450	COG2197	response regulator
K05K4_40470	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K05K4_40480	COG0583	DNA-binding transcription factor activity
K05K4_40490	COG0243	molybdopterin cofactor binding
K05K4_40520	COG0384	phenazine biosynthesis protein PhzF
K05K4_40530	COG1794	racemase activity, acting on amino acids and derivatives
K05K4_40590	COG1328	CTP reductase activity
K05K4_40600	COG0602	queuosine metabolic process
K05K4_40610	COG0534	Mate efflux family protein
K05K4_40620	COG2207	Transcriptional regulator
K05K4_40640	COG0189	ligase activity
K05K4_40640	COG4067	protein conserved in archaea
K05K4_40660	COG3111	PFAM Bacterial OB fold (BOF) protein
K05K4_40680	COG0725	ABC transporter, periplasmic molybdate-binding protein
K05K4_40690	COG4149	molybdate abc transporter
K05K4_40700	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K05K4_40720	COG3706	GGDEF domain
K05K4_40720	COG5001	Diguanylate cyclase
K05K4_40720	COG4251	negative regulation of phosphorylation
K05K4_40720	COG2203	Gaf domain
K05K4_40730	COG0745	RESPONSE REGULATOR receiver
K05K4_40730	COG3706	GGDEF domain
K05K4_40760	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K05K4_40770	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K05K4_40820	COG3140	Belongs to the UPF0181 family
K05K4_40850	COG0583	DNA-binding transcription factor activity
K05K4_41150	COG0023	Translation Initiation Factor
K05K4_41170	COG1181	Belongs to the D-alanine--D-alanine ligase family
K05K4_41190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K05K4_41190	COG1042	CoA-binding domain protein
K05K4_41190	COG0045	succinate-CoA ligase (ADP-forming) activity
K05K4_41200	COG0583	DNA-binding transcription factor activity
K05K4_41230	COG5002	protein histidine kinase activity
K05K4_41230	COG5001	Diguanylate cyclase
K05K4_41230	COG3447	MASE1 domain protein
K05K4_41240	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K05K4_41250	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K05K4_41260	COG1984	allophanate hydrolase subunit 2
K05K4_41280	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K05K4_41290	COG4181	ATPase activity
K05K4_41310	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K05K4_41320	COG3300	MHYT domain
K05K4_41320	COG5001	Diguanylate cyclase
K05K4_41390	COG4533	DNA binding
K05K4_41410	COG2050	protein possibly involved in aromatic compounds catabolism
K05K4_41440	COG2067	long-chain fatty acid transport protein
K05K4_41450	COG2267	carboxylic ester hydrolase activity
K05K4_41490	COG0861	Integral membrane protein TerC family
K05K4_41500	COG0737	Belongs to the 5'-nucleotidase family
K05K4_41510	COG3593	DNA synthesis involved in DNA repair
K05K4_41530	COG0583	DNA-binding transcription factor activity
K05K4_41550	COG2116	formate transmembrane transporter activity
K05K4_41560	COG2353	YceI-like domain
K05K4_41570	COG3038	cytochrome b561
K05K4_41610	COG0513	Belongs to the DEAD box helicase family
K05K4_41620	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
K05K4_41640	COG0840	transmembrane signaling receptor activity
K05K4_41650	COG0546	phosphoglycolate phosphatase activity
K05K4_41680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K05K4_41690	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K05K4_41700	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K05K4_41720	COG2207	Transcriptional regulator
K05K4_41730	COG1979	alcohol dehydrogenase
K05K4_41750	COG1126	abc transporter atp-binding protein
K05K4_41760	COG0765	amino acid transport
K05K4_41770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K05K4_41780	COG0765	amino acid transport
K05K4_41790	COG2200	EAL domain
K05K4_41790	COG2203	Gaf domain
K05K4_41790	COG2199	diguanylate cyclase activity
K05K4_41820	COG1609	Transcriptional regulator
K05K4_41830	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K05K4_41830	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K05K4_41840	COG1105	Belongs to the carbohydrate kinase PfkB family
K05K4_41850	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K05K4_41850	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
K05K4_41850	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K05K4_41910	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K05K4_41930	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K05K4_41940	COG0509	glycine decarboxylation via glycine cleavage system
K05K4_41960	COG0346	lactoylglutathione lyase activity
K05K4_41970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K05K4_41980	COG0583	DNA-binding transcription factor activity
K05K4_41990	COG0697	spore germination
K05K4_42000	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K05K4_42060	COG2176	DNA-directed DNA polymerase activity
K05K4_42140	COG0242	peptide deformylase activity
K05K4_42200	COG2239	Acts as a magnesium transporter
K05K4_42240	COG0346	lactoylglutathione lyase activity
K05K4_42250	COG1902	pentaerythritol trinitrate reductase activity
K05K4_42270	COG2755	lipolytic protein G-D-S-L family
K05K4_42270	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K05K4_42300	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K05K4_42310	COG0069	glutamate synthase activity
K05K4_42310	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K05K4_42370	COG2076	Multidrug Resistance protein
K05K4_42410	COG2962	Rard protein
K05K4_42440	COG0784	Response regulator, receiver
K05K4_42440	COG0835	chemotaxis
K05K4_42450	COG2197	response regulator
K05K4_42470	COG3706	GGDEF domain
K05K4_42480	COG2197	response regulator
K05K4_42490	COG5001	Diguanylate cyclase
K05K4_42490	COG3300	MHYT domain
K05K4_42500	COG2205	protein histidine kinase activity
K05K4_42500	COG0784	Response regulator, receiver
K05K4_42510	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K05K4_42550	COG1214	PFAM Peptidase M22, glycoprotease
K05K4_42550	COG0456	acetyltransferase
K05K4_42570	COG3069	C4-dicarboxylate transmembrane transporter activity
K05K4_42620	COG3111	PFAM Bacterial OB fold (BOF) protein
K05K4_42630	COG1597	lipid kinase activity
K05K4_42640	COG0583	DNA-binding transcription factor activity
K05K4_42650	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K05K4_42710	COG0714	Associated with various cellular activities
K05K4_42720	COG0641	radical SAM
K05K4_42730	COG3119	arylsulfatase activity
K05K4_42750	COG3119	arylsulfatase activity
K05K4_42760	COG0745	RESPONSE REGULATOR receiver
K05K4_42790	COG2198	Histidine kinase
K05K4_42790	COG0784	Response regulator, receiver
K05K4_42790	COG2205	protein histidine kinase activity
K05K4_42800	COG1879	ABC-type sugar transport system periplasmic component
K05K4_42810	COG1803	Methylglyoxal synthase
K05K4_42820	COG0210	DNA helicase
K05K4_42830	COG1289	transmembrane transporter activity
K05K4_42890	COG1629	transport
K05K4_42890	COG4771	TonB-dependent receptor
K05K4_42910	COG0789	Transcriptional regulator
K05K4_42920	COG4604	ABC transporter, ATP-binding protein
K05K4_42930	COG4605	iron ion homeostasis
K05K4_42940	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K05K4_42950	COG4607	ABC-type enterochelin transport system periplasmic component
K05K4_42970	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
K05K4_43000	COG1609	Transcriptional regulator
K05K4_43010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K05K4_43020	COG1879	ABC-type sugar transport system periplasmic component
K05K4_43030	COG1172	Belongs to the binding-protein-dependent transport system permease family
K05K4_43040	COG1129	ABC transporter
K05K4_43050	COG1869	D-ribose catabolic process
K05K4_43060	COG5001	Diguanylate cyclase
K05K4_43160	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K05K4_43180	COG0784	Response regulator, receiver
K05K4_43180	COG2205	protein histidine kinase activity
K05K4_43210	COG0330	HflC and HflK could
K05K4_43240	COG0517	IMP dehydrogenase activity
K05K4_43240	COG4175	Glycine betaine
K05K4_43250	COG4176	ABC-type proline glycine betaine transport system permease component
K05K4_43280	COG1012	belongs to the aldehyde dehydrogenase family
K05K4_43290	COG1309	transcriptional regulator
K05K4_43300	COG0745	RESPONSE REGULATOR receiver
K05K4_43300	COG3706	GGDEF domain
K05K4_43310	COG1028	Short-chain dehydrogenase reductase Sdr
K05K4_43340	COG1024	Enoyl-CoA hydratase
K05K4_43350	COG1960	acyl-CoA dehydrogenase activity
K05K4_43370	COG0183	Belongs to the thiolase family
K05K4_43390	COG1960	acyl-CoA dehydrogenase activity
K05K4_43400	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K05K4_43450	COG3264	Mechanosensitive ion channel
K05K4_43450	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K05K4_43460	COG0110	maltose O-acetyltransferase activity
K05K4_43470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K05K4_43480	COG1271	oxidase subunit
K05K4_43490	COG1294	oxidase, subunit
K05K4_43510	COG0384	phenazine biosynthesis protein PhzF
K05K4_43550	COG3527	Alpha-acetolactate decarboxylase
K05K4_43570	COG1028	Short-chain dehydrogenase reductase Sdr
K05K4_43580	COG0500	methyltransferase
K05K4_43640	COG1022	Amp-dependent synthetase and ligase
K05K4_43690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K05K4_43700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K05K4_43700	COG1263	PTS System
K05K4_43710	COG1486	melibiose metabolic process
K05K4_43720	COG2188	Transcriptional regulator
K05K4_43730	COG1320	monovalent cation:proton antiporter activity
K05K4_43740	COG2212	antiporter activity
K05K4_43770	COG1006	Multisubunit Na H antiporter MnhC subunit
K05K4_43780	COG2111	Na H antiporter
K05K4_43780	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K05K4_43800	COG0589	response to stress
K05K4_43810	COG4221	oxidoreductase activity
K05K4_43820	COG0583	DNA-binding transcription factor activity
K05K4_43840	COG2814	Major facilitator Superfamily
K05K4_43970	COG1522	sequence-specific DNA binding
K05K4_44040	COG0515	serine threonine protein kinase
K05K4_44090	COG3501	Rhs element vgr protein
K05K4_44120	COG2204	response regulator
K05K4_44180	COG0739	heme binding
K05K4_44210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K05K4_44310	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K05K4_44330	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K05K4_44330	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K05K4_44360	COG4989	oxidoreductase activity
K05K4_44390	COG0038	chloride channel
K05K4_44460	COG2897	thiosulfate sulfurtransferase activity
K05K4_44480	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K05K4_44490	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K05K4_44500	COG0840	transmembrane signaling receptor activity
K05K4_44510	COG2814	Major facilitator Superfamily
K05K4_44520	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K05K4_44540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K05K4_44560	COG0840	transmembrane signaling receptor activity
K05K4_44600	COG2195	Cleaves the N-terminal amino acid of tripeptides
K05K4_44630	COG2197	response regulator
K05K4_44640	COG3850	Histidine kinase
K05K4_44650	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K05K4_44670	COG0243	molybdopterin cofactor binding
K05K4_44690	COG3005	denitrification pathway
K05K4_44710	COG3243	poly(R)-hydroxyalkanoic acid synthase
K05K4_44730	COG0183	Belongs to the thiolase family
K05K4_44750	COG1280	lysine exporter protein (LysE YggA)
K05K4_44770	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K05K4_44780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K05K4_44880	COG1846	Transcriptional regulator
K05K4_44890	COG0784	Response regulator, receiver
K05K4_44890	COG2205	protein histidine kinase activity
K05K4_44900	COG1879	ABC-type sugar transport system periplasmic component
K05K4_44910	COG2827	Endonuclease containing a URI domain
K05K4_44920	COG3132	Protein of unknown function, DUF480
K05K4_44960	COG2205	protein histidine kinase activity
K05K4_44960	COG0784	Response regulator, receiver
K05K4_44960	COG5002	protein histidine kinase activity
K05K4_45020	COG0583	DNA-binding transcription factor activity
K05K4_45040	COG0531	amino acid
K05K4_45070	COG2205	protein histidine kinase activity
K05K4_45080	COG0745	RESPONSE REGULATOR receiver
K05K4_45140	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K05K4_45150	COG2239	Acts as a magnesium transporter
K05K4_45160	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K05K4_45170	COG0402	S-adenosylhomocysteine deaminase activity
K05K4_45180	COG1418	mRNA catabolic process
K05K4_45200	COG2814	Major facilitator Superfamily
K05K4_45220	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K05K4_45250	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K05K4_45280	COG0745	RESPONSE REGULATOR receiver
K05K4_45290	COG2205	protein histidine kinase activity
K05K4_45310	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K05K4_45320	COG2194	sulfuric ester hydrolase activity
K05K4_45360	COG4667	esterase of the alpha-beta hydrolase superfamily
K05K4_45370	COG1741	Belongs to the pirin family
K05K4_45380	COG1278	Cold shock
K05K4_45410	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K05K4_45420	COG0678	peroxiredoxin activity
K05K4_45420	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K05K4_45440	COG1686	Belongs to the peptidase S11 family
K05K4_45460	COG0625	glutathione transferase activity
K05K4_45470	COG1621	beta-fructofuranosidase activity
K05K4_45480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K05K4_45490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K05K4_45490	COG1263	PTS System
K05K4_45530	COG1028	Short-chain dehydrogenase reductase Sdr
K05K4_45560	COG3746	phosphate-selective porin O and P
K05K4_45590	COG0300	oxidoreductase activity
K05K4_45600	COG0583	DNA-binding transcription factor activity
K05K4_45610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K05K4_45610	COG2207	Transcriptional regulator
K05K4_45620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K05K4_45660	COG0513	Belongs to the DEAD box helicase family
K05K4_45690	COG0583	DNA-binding transcription factor activity
K05K4_45720	COG1902	pentaerythritol trinitrate reductase activity
K05K4_45730	COG1063	alcohol dehydrogenase
K05K4_45750	COG1028	Short-chain dehydrogenase reductase Sdr
K05K4_45770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K05K4_45780	COG0006	proline dipeptidase activity
K05K4_45790	COG3608	succinylglutamate desuccinylase aspartoacylase
K05K4_45800	COG1522	sequence-specific DNA binding
K05K4_45810	COG1012	belongs to the aldehyde dehydrogenase family
K05K4_45820	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K05K4_45830	COG3122	Protein conserved in bacteria
K05K4_45860	COG0583	DNA-binding transcription factor activity
K05K4_45880	COG0252	asparaginase activity
K05K4_45890	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K05K4_45920	COG2197	response regulator
K05K4_45930	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K05K4_45940	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K05K4_45980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K05K4_46040	COG3842	ATPase activity
K05K4_46080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K05K4_46140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K05K4_46150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K05K4_46160	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K05K4_46220	COG0583	DNA-binding transcription factor activity
K05K4_46240	COG4948	Mandelate Racemase Muconate Lactonizing
K05K4_46250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K05K4_46300	COG1342	Belongs to the UPF0251 family
K05K4_46310	COG4176	ABC-type proline glycine betaine transport system permease component
K05K4_46320	COG4175	Glycine betaine
K05K4_46320	COG3448	diguanylate cyclase activity
K05K4_46330	COG3015	lipoprotein NlpE involved in copper resistance
K05K4_46340	COG3713	MltA-interacting MipA family protein
K05K4_46370	COG0583	DNA-binding transcription factor activity
K05K4_46420	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K05K4_46440	COG1335	isochorismatase
K05K4_46470	COG1349	DNA-binding transcription factor activity
K05K4_46490	COG2070	2-Nitropropane dioxygenase
K05K4_46500	COG0531	amino acid
K05K4_46510	COG4302	ethanolamine ammonia-lyase activity
K05K4_46520	COG4303	Ethanolamine ammonia lyase large subunit
K05K4_46540	COG1309	transcriptional regulator
K05K4_46580	COG1280	lysine exporter protein (LysE YggA)
K05K4_46600	COG0459	protein refolding
K05K4_46610	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K05K4_46620	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K05K4_46650	COG1304	FMN binding
K05K4_46700	COG1256	bacterial-type flagellum assembly
K05K4_46700	COG4786	Flagellar basal body rod
K05K4_46720	COG1706	bacterial-type flagellum-dependent cell motility
K05K4_46730	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K05K4_46740	COG4786	Flagellar basal body rod
K05K4_46750	COG4787	bacterial-type flagellum-dependent cell motility
K05K4_46760	COG1749	Flagellar hook protein flgE
K05K4_46770	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K05K4_46780	COG1558	bacterial-type flagellum-dependent cell motility
K05K4_46790	COG1815	bacterial-type flagellum-dependent cell motility
K05K4_46830	COG0741	lytic transglycosylase activity
K05K4_46840	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K05K4_46880	COG1760	l-serine dehydratase
K05K4_46910	COG0583	DNA-binding transcription factor activity
K05K4_46930	COG2866	Carboxypeptidase
K05K4_46940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K05K4_46960	COG2990	Protein conserved in bacteria
K05K4_47010	COG3842	ATPase activity
K05K4_47030	COG1840	ABC-type Fe3 transport system, periplasmic component
K05K4_47070	COG1609	Transcriptional regulator
K05K4_47130	COG3240	lipase activity
K05K4_47140	COG1309	transcriptional regulator
K05K4_47170	COG0577	efflux transmembrane transporter activity
K05K4_47170	COG1136	(ABC) transporter
K05K4_47180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K05K4_47190	COG2067	long-chain fatty acid transport protein
K05K4_47200	COG3338	carbonate dehydratase activity
K05K4_47210	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K05K4_47240	COG1011	Hydrolase
K05K4_47310	COG0110	maltose O-acetyltransferase activity
K05K4_47320	COG1765	OsmC-like protein
K05K4_47330	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K05K4_47330	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K05K4_47350	COG3046	protein related to deoxyribodipyrimidine photolyase
K05K4_47360	COG0415	Belongs to the DNA photolyase family
K05K4_47370	COG3706	GGDEF domain
K05K4_47400	COG3706	GGDEF domain
K05K4_47430	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K05K4_47460	COG3033	Beta-eliminating lyase
K05K4_47490	COG1271	oxidase subunit
K05K4_47500	COG1294	oxidase, subunit
K05K4_47530	COG3179	chitinase
K05K4_47540	COG0579	oxidoreductase
K05K4_47590	COG3706	GGDEF domain
K05K4_47650	COG0583	DNA-binding transcription factor activity
K05K4_47690	COG0189	ligase activity
K05K4_47700	COG4067	protein conserved in archaea
K05K4_47700	COG0189	ligase activity
K05K4_47720	COG1166	arginine decarboxylase activity
K05K4_47730	COG0010	Belongs to the arginase family
K05K4_47740	COG2814	Major facilitator Superfamily
K05K4_47750	COG1770	oligopeptidase
K05K4_47780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K05K4_47790	COG1121	(ABC) transporter
K05K4_47800	COG0803	Belongs to the bacterial solute-binding protein 9 family
K05K4_47880	COG0848	biopolymer transport protein
K05K4_47890	COG0811	peptide transport
K05K4_47900	COG0811	peptide transport
K05K4_47940	COG0745	RESPONSE REGULATOR receiver
K05K4_47950	COG0584	glycerophosphoryl diester phosphodiesterase
K05K4_47970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K05K4_48100	COG0312	modulator of DNA gyrase
K05K4_48110	COG0312	modulator of DNA gyrase
K05K4_48120	COG0351	phosphomethylpyrimidine kinase
K05K4_48130	COG1116	anion transmembrane transporter activity
K05K4_48140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K05K4_48150	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K05K4_48160	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K05K4_48200	COG0243	molybdopterin cofactor binding
K05K4_48210	COG3005	denitrification pathway
K05K4_48220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K05K4_48230	COG1028	Short-chain dehydrogenase reductase Sdr
K05K4_48260	COG0456	acetyltransferase
K05K4_48300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K05K4_48310	COG1929	Belongs to the glycerate kinase type-1 family
K05K4_48320	COG2610	gluconate transmembrane transporter activity
K05K4_48330	COG3835	regulator
K05K4_48460	COG3047	cAMP biosynthetic process
K05K4_48480	COG1357	PFAM Pentapeptide repeats (8 copies)
K05K4_48540	COG2375	cellular response to nickel ion
K05K4_48550	COG0583	DNA-binding transcription factor activity
K05K4_48560	COG2162	N-hydroxyarylamine O-acetyltransferase activity
K05K4_48570	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K05K4_48620	COG2199	diguanylate cyclase activity
K05K4_48640	COG0561	phosphatase activity
K05K4_48650	COG0583	DNA-binding transcription factor activity
K05K4_48680	COG0564	pseudouridine synthase activity
K05K4_48690	COG0534	Mate efflux family protein
K05K4_48700	COG5001	Diguanylate cyclase
K05K4_48720	COG3123	guanosine phosphorylase activity
K05K4_48750	COG0596	Alpha beta hydrolase
K05K4_48810	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K05K4_48830	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K05K4_48840	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K05K4_48840	COG2169	Transcriptional regulator
K05K4_48860	COG2259	Doxx family
K05K4_48870	COG1741	Belongs to the pirin family
K05K4_48910	COG0363	glucosamine-6-phosphate deaminase activity
K05K4_48930	COG0786	glutamate:sodium symporter activity
K05K4_48940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K05K4_48950	COG1131	(ABC) transporter
K05K4_48970	COG0786	glutamate:sodium symporter activity
K05K4_49010	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K05K4_49030	COG3279	Response regulator of the LytR AlgR family
K05K4_49040	COG3275	phosphorelay sensor kinase activity
K05K4_49100	COG0772	Belongs to the SEDS family
K05K4_49150	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
K05K4_49150	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K05K4_49170	COG0444	Belongs to the ABC transporter superfamily
K05K4_49180	COG4608	Belongs to the ABC transporter superfamily
K05K4_50130	COG0358	DNA primase activity
K05K4_50720	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K05K4_51110	COG2916	Histone family protein nucleoid-structuring protein H-NS
K05K4_51660	COG0330	HflC and HflK could
K05K4_51670	COG0330	HflC and HflK could
K05K4_51780	COG2203	Gaf domain
K05K4_51780	COG4251	negative regulation of phosphorylation
K05K4_51780	COG3706	GGDEF domain
K05K4_51780	COG5001	Diguanylate cyclase
K05K4_52000	COG0358	DNA primase activity
K05K4_52500	COG4128	Pfam Zonular occludens toxin
K05K4_52620	COG4128	Pfam Zonular occludens toxin
K05K4_52840	COG4128	Pfam Zonular occludens toxin