locus-tag	class	description
K06K5_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K06K5_00020	COG0592	DNA-directed DNA polymerase activity
K06K5_00040	COG0187	DNA topoisomerase II activity
K06K5_00070	COG0071	Belongs to the small heat shock protein (HSP20) family
K06K5_00080	COG3977	Valine--pyruvate aminotransferase
K06K5_00090	COG0366	Alpha amylase catalytic
K06K5_00120	COG2119	membrane
K06K5_00140	COG0425	Belongs to the sulfur carrier protein TusA family
K06K5_00170	COG0604	alcohol dehydrogenase
K06K5_00180	COG0183	Belongs to the thiolase family
K06K5_00200	COG1739	Uncharacterized protein family UPF0029
K06K5_00210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K06K5_00290	COG0583	DNA-binding transcription factor activity
K06K5_00300	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K06K5_00310	COG2960	long-chain fatty acid transporting porin activity
K06K5_00320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K06K5_00330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K06K5_00430	COG4172	Belongs to the ABC transporter superfamily
K06K5_00440	COG4166	transmembrane transport
K06K5_00460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K06K5_00480	COG1609	Transcriptional regulator
K06K5_00490	COG0583	DNA-binding transcription factor activity
K06K5_00510	COG2076	Multidrug Resistance protein
K06K5_00520	COG0129	dihydroxy-acid dehydratase activity
K06K5_00530	COG3265	gluconokinase activity
K06K5_00540	COG2610	gluconate transmembrane transporter activity
K06K5_00550	COG0800	Aldolase
K06K5_00560	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K06K5_00570	COG0583	DNA-binding transcription factor activity
K06K5_00580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K06K5_00590	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K06K5_00610	COG1522	sequence-specific DNA binding
K06K5_00620	COG5002	protein histidine kinase activity
K06K5_00620	COG5001	Diguanylate cyclase
K06K5_00630	COG0742	ribosomal rna small subunit methyltransferase
K06K5_00650	COG0697	spore germination
K06K5_00660	COG0589	response to stress
K06K5_00670	COG1528	Iron-storage protein
K06K5_00690	COG2081	HI0933 family
K06K5_00750	COG1597	lipid kinase activity
K06K5_00810	COG0628	permease
K06K5_00840	COG1322	Protein conserved in bacteria
K06K5_00850	COG2226	methyltransferase
K06K5_00860	COG3165	ubiquinone biosynthetic process from chorismate
K06K5_00870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K06K5_00900	COG0805	protein transport
K06K5_00910	COG0084	hydrolase, TatD family'
K06K5_00930	COG0456	acetyltransferase
K06K5_00950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K06K5_00950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K06K5_00960	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K06K5_01010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K06K5_01020	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K06K5_01040	COG2204	response regulator
K06K5_01050	COG3852	Histidine kinase
K06K5_01070	COG0174	glutamine synthetase
K06K5_01090	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K06K5_01110	COG1295	ribonuclease BN
K06K5_01120	COG1490	D-aminoacyl-tRNA deacylase activity
K06K5_01130	COG0456	acetyltransferase
K06K5_01150	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K06K5_01160	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K06K5_01170	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K06K5_01180	COG3031	protein transport across the cell outer membrane
K06K5_01200	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K06K5_01210	COG1459	type II secretion system
K06K5_01220	COG2165	general secretion pathway protein
K06K5_01230	COG2165	general secretion pathway protein
K06K5_01240	COG2165	general secretion pathway protein
K06K5_01250	COG4795	General secretion pathway protein
K06K5_01260	COG3156	type II secretion system protein K
K06K5_01270	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K06K5_01280	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K06K5_01300	COG1218	3'(2'),5'-bisphosphate nucleotidase
K06K5_01310	COG0494	nUDIX hydrolase
K06K5_01330	COG1040	competence protein
K06K5_01360	COG2183	response to ionizing radiation
K06K5_01380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K06K5_01400	COG0745	RESPONSE REGULATOR receiver
K06K5_01410	COG2205	protein histidine kinase activity
K06K5_01420	COG2233	PERMEase
K06K5_01430	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K06K5_01440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K06K5_01450	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K06K5_01460	COG1758	RNA polymerase activity
K06K5_01470	COG0194	GDP metabolic process
K06K5_01500	COG0848	biopolymer transport protein
K06K5_01510	COG0811	peptide transport
K06K5_01550	COG4174	ABC transporter (Permease)
K06K5_01560	COG4239	(ABC) transporter, permease
K06K5_01570	COG0747	negative chemotaxis
K06K5_01580	COG0444	Belongs to the ABC transporter superfamily
K06K5_01590	COG4608	Belongs to the ABC transporter superfamily
K06K5_01610	COG1561	YicC-like family, N-terminal region
K06K5_01620	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K06K5_01630	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K06K5_01640	COG1560	Kdo2-lipid A biosynthetic process
K06K5_01650	COG1309	transcriptional regulator
K06K5_01660	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K06K5_01680	COG2003	Belongs to the UPF0758 family
K06K5_01730	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K06K5_01760	COG0463	Glycosyl transferase, family 2
K06K5_01770	COG0859	PFAM glycosyl transferase family 9
K06K5_01780	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K06K5_01790	COG3642	lipopolysaccharide core region biosynthetic process
K06K5_01810	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K06K5_01890	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K06K5_01900	COG1519	Transferase
K06K5_01910	COG0859	PFAM glycosyl transferase family 9
K06K5_01930	COG1560	Kdo2-lipid A biosynthetic process
K06K5_01970	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K06K5_02070	COG0438	transferase activity, transferring glycosyl groups
K06K5_02090	COG0297	glycogen (starch) synthase activity
K06K5_02090	COG0438	transferase activity, transferring glycosyl groups
K06K5_02110	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K06K5_02120	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K06K5_02130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K06K5_02190	COG1215	transferase activity, transferring glycosyl groups
K06K5_02240	COG0149	triose-phosphate isomerase activity
K06K5_02290	COG1494	fructose-1,6-bisphosphatase
K06K5_02310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K06K5_02320	COG1575	Belongs to the MenA family. Type 1 subfamily
K06K5_02380	COG2003	Belongs to the UPF0758 family
K06K5_02410	COG4565	transcriptional regulatory protein
K06K5_02430	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K06K5_02440	COG0511	ligase activity, forming carbon-carbon bonds
K06K5_02440	COG5016	pyruvate
K06K5_02450	COG3630	sodium ion export across plasma membrane
K06K5_02470	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
K06K5_02480	COG3052	prosthetic group binding
K06K5_02490	COG2301	Belongs to the HpcH HpaI aldolase family
K06K5_02500	COG3051	citrate lyase alpha subunit
K06K5_02510	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
K06K5_02520	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
K06K5_02550	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K06K5_02560	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K06K5_02590	COG1609	Transcriptional regulator
K06K5_02600	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K06K5_02610	COG0254	rRNA binding
K06K5_02630	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K06K5_02640	COG0088	Forms part of the polypeptide exit tunnel
K06K5_02660	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K06K5_02670	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K06K5_02680	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K06K5_02690	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K06K5_02710	COG0255	Belongs to the universal ribosomal protein uL29 family
K06K5_02720	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K06K5_02740	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K06K5_02750	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K06K5_02760	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K06K5_02770	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K06K5_02780	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K06K5_02810	COG1841	ribosomal large subunit assembly
K06K5_02830	COG0201	protein transport
K06K5_02850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K06K5_02860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K06K5_02880	COG0202	RNA polymerase activity
K06K5_02890	COG0203	ribosomal protein L17
K06K5_02910	COG0545	Peptidyl-prolyl cis-trans isomerase
K06K5_02930	COG2153	protein acetylation
K06K5_02940	COG0513	Belongs to the DEAD box helicase family
K06K5_02970	COG1648	precorrin-2 dehydrogenase activity
K06K5_02970	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K06K5_02980	COG0175	sulfate reduction
K06K5_02990	COG2895	sulfate adenylyltransferase (ATP) activity
K06K5_03000	COG0471	metal ion transport
K06K5_03000	COG3273	potassium ion transport
K06K5_03010	COG0529	Catalyzes the synthesis of activated sulfate
K06K5_03060	COG4181	ATPase activity
K06K5_03090	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K06K5_03110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K06K5_03120	COG0729	surface antigen
K06K5_03130	COG2911	Protein conserved in bacteria
K06K5_03140	COG2105	PFAM AIG2 family protein
K06K5_03160	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K06K5_03170	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K06K5_03180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K06K5_03190	COG0163	prenyltransferase activity
K06K5_03200	COG4143	(ABC) transporter
K06K5_03210	COG1178	ABC-type Fe3 transport system permease component
K06K5_03220	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K06K5_03230	COG0583	DNA-binding transcription factor activity
K06K5_03240	COG1902	pentaerythritol trinitrate reductase activity
K06K5_03310	COG0142	geranyltranstransferase activity
K06K5_03320	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K06K5_03340	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K06K5_03350	COG2966	Psort location CytoplasmicMembrane, score
K06K5_03370	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K06K5_03380	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K06K5_03390	COG2967	ApaG domain
K06K5_03400	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K06K5_03410	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K06K5_03420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K06K5_03430	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K06K5_03440	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K06K5_03480	COG0473	3-isopropylmalate dehydrogenase activity
K06K5_03490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K06K5_03530	COG0583	DNA-binding transcription factor activity
K06K5_03540	COG1022	Amp-dependent synthetase and ligase
K06K5_03550	COG0028	Belongs to the TPP enzyme family
K06K5_03560	COG0440	acetolactate synthase activity
K06K5_03570	COG3706	GGDEF domain
K06K5_03590	COG0469	pyruvate kinase activity
K06K5_03600	COG1349	DNA-binding transcription factor activity
K06K5_03610	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K06K5_03630	COG2376	Dihydroxyacetone kinase
K06K5_03640	COG1461	Dihydroxyacetone kinase
K06K5_03670	COG3722	fumarate hydratase activity
K06K5_03690	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K06K5_03690	COG2213	PTS system mannitol-specific
K06K5_03750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K06K5_03760	COG0358	DNA primase activity
K06K5_03770	COG1610	YqeY-like protein
K06K5_03780	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K06K5_03790	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K06K5_03800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K06K5_03810	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K06K5_03820	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K06K5_03830	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K06K5_03840	COG1968	undecaprenyl-diphosphatase activity
K06K5_03860	COG3409	Peptidoglycan-binding domain 1 protein
K06K5_03860	COG3267	Type II secretory pathway component ExeA
K06K5_03880	COG0405	Gamma-glutamyltransferase
K06K5_03890	COG4991	sh3 domain protein
K06K5_03900	COG0306	phosphate transporter
K06K5_03910	COG1392	Phosphate transport regulator
K06K5_03920	COG3025	triphosphatase activity
K06K5_03950	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K06K5_03960	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K06K5_03960	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K06K5_03970	COG1538	Outer membrane efflux protein
K06K5_03980	COG0494	nUDIX hydrolase
K06K5_03990	COG3151	Protein conserved in bacteria
K06K5_04010	COG3150	esterase
K06K5_04020	COG0187	DNA topoisomerase II activity
K06K5_04030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K06K5_04040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K06K5_04060	COG3105	Protein conserved in bacteria
K06K5_04070	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K06K5_04090	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K06K5_04100	COG0723	plastoquinol--plastocyanin reductase activity
K06K5_04110	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K06K5_04120	COG2857	Cytochrome c1
K06K5_04130	COG0625	glutathione transferase activity
K06K5_04140	COG2969	positive regulation of protein catabolic process
K06K5_04170	COG2823	Periplasmic or secreted lipoprotein
K06K5_04180	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K06K5_04210	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K06K5_04230	COG3116	cell division
K06K5_04240	COG0768	penicillin binding
K06K5_04250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K06K5_04260	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K06K5_04270	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K06K5_04280	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K06K5_04290	COG0772	Belongs to the SEDS family
K06K5_04320	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K06K5_04330	COG0849	cell division
K06K5_04340	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K06K5_04350	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K06K5_04370	COG0653	protein targeting
K06K5_04380	COG0494	nUDIX hydrolase
K06K5_04400	COG0505	Belongs to the CarA family
K06K5_04410	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K06K5_04440	COG0730	response to heat
K06K5_04450	COG0583	DNA-binding transcription factor activity
K06K5_04460	COG2860	membrane
K06K5_04490	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K06K5_04510	COG0493	'glutamate synthase
K06K5_04520	COG0070	glutamate synthase
K06K5_04520	COG0067	glutamate synthase
K06K5_04520	COG0069	glutamate synthase activity
K06K5_04540	COG0069	glutamate synthase activity
K06K5_04540	COG0067	glutamate synthase
K06K5_04540	COG0070	glutamate synthase
K06K5_04550	COG1242	4 iron, 4 sulfur cluster binding
K06K5_04560	COG5001	Diguanylate cyclase
K06K5_04560	COG4251	negative regulation of phosphorylation
K06K5_04560	COG2203	Gaf domain
K06K5_04560	COG3706	GGDEF domain
K06K5_04570	COG5002	protein histidine kinase activity
K06K5_04570	COG0784	Response regulator, receiver
K06K5_04570	COG2198	Histidine kinase
K06K5_04590	COG0745	RESPONSE REGULATOR receiver
K06K5_04610	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K06K5_04640	COG0083	homoserine kinase activity
K06K5_04650	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K06K5_04670	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
K06K5_04680	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K06K5_04690	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K06K5_04720	COG1115	amino acid carrier protein
K06K5_04730	COG3022	response to hydroperoxide
K06K5_04740	COG0513	Belongs to the DEAD box helicase family
K06K5_04750	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K06K5_04770	COG0716	FMN binding
K06K5_04790	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K06K5_04800	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K06K5_04810	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K06K5_04830	COG2204	response regulator
K06K5_04860	COG0667	Aldo Keto reductase
K06K5_04910	COG0730	response to heat
K06K5_04930	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K06K5_04950	COG1283	sodium-dependent phosphate transmembrane transporter activity
K06K5_04960	COG0583	DNA-binding transcription factor activity
K06K5_04970	COG0640	Transcriptional regulator
K06K5_04980	COG0268	Binds directly to 16S ribosomal RNA
K06K5_04990	COG0728	peptidoglycan biosynthetic process
K06K5_05000	COG0196	riboflavin kinase activity
K06K5_05030	COG1047	Peptidyl-prolyl cis-trans
K06K5_05040	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K06K5_05060	COG3279	Response regulator of the LytR AlgR family
K06K5_05070	COG3275	phosphorelay sensor kinase activity
K06K5_05080	COG1966	Carbon starvation protein
K06K5_05120	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K06K5_05130	COG1472	Belongs to the glycosyl hydrolase 3 family
K06K5_05140	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K06K5_05150	COG1605	Chorismate mutase
K06K5_05150	COG0287	Prephenate dehydrogenase
K06K5_05160	COG0739	heme binding
K06K5_05180	COG0488	(ABC) transporter
K06K5_05200	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
K06K5_05210	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
K06K5_05220	COG1605	Chorismate mutase
K06K5_05220	COG0077	Prephenate dehydratase
K06K5_05230	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K06K5_05250	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K06K5_05260	COG0564	pseudouridine synthase activity
K06K5_05280	COG0542	response to heat
K06K5_05410	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K06K5_05430	COG2974	May be involved in recombination
K06K5_05440	COG0745	RESPONSE REGULATOR receiver
K06K5_05450	COG5002	protein histidine kinase activity
K06K5_05470	COG0248	Ppx GppA phosphatase
K06K5_05480	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K06K5_05490	COG0573	inorganic phosphate transmembrane transporter activity
K06K5_05500	COG0581	inorganic phosphate transmembrane transporter activity
K06K5_05510	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K06K5_05520	COG0704	Plays a role in the regulation of phosphate uptake
K06K5_05540	COG3142	Participates in the control of copper homeostasis
K06K5_05550	COG0450	alkyl hydroperoxide reductase
K06K5_05560	COG0583	DNA-binding transcription factor activity
K06K5_05570	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K06K5_05590	COG0517	IMP dehydrogenase activity
K06K5_05610	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K06K5_05630	COG1862	Preprotein translocase
K06K5_05640	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K06K5_05650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K06K5_05680	COG0483	inositol monophosphate 1-phosphatase activity
K06K5_05690	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
K06K5_05710	COG1104	cysteine desulfurase activity
K06K5_05720	COG0822	iron-sulfur transferase activity
K06K5_05750	COG0443	Heat shock 70 kDa protein
K06K5_05760	COG0633	Ferredoxin
K06K5_05770	COG2975	iron-sulfur cluster assembly
K06K5_05790	COG0105	UTP biosynthetic process
K06K5_05820	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K06K5_05830	COG0124	histidyl-tRNA synthetase
K06K5_05840	COG2976	Protein conserved in bacteria
K06K5_05850	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K06K5_05860	COG1160	GTP binding
K06K5_05980	COG0582	viral genome integration into host DNA
K06K5_05990	COG0582	viral genome integration into host DNA
K06K5_06060	COG0633	Ferredoxin
K06K5_06070	COG2975	iron-sulfur cluster assembly
K06K5_06110	COG0105	UTP biosynthetic process
K06K5_06160	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K06K5_06170	COG0124	histidyl-tRNA synthetase
K06K5_06180	COG2976	Protein conserved in bacteria
K06K5_06190	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K06K5_06200	COG1160	GTP binding
K06K5_06240	COG0517	IMP dehydrogenase activity
K06K5_06240	COG0516	GMP reductase activity
K06K5_06260	COG0582	viral genome integration into host DNA
K06K5_06400	COG1757	Na H antiporter
K06K5_06420	COG1584	GPR1 FUN34 yaaH family protein
K06K5_06430	COG1115	amino acid carrier protein
K06K5_06460	COG2873	o-acetylhomoserine
K06K5_06470	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K06K5_06510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K06K5_06510	COG3153	acetyltransferase
K06K5_06520	COG0583	DNA-binding transcription factor activity
K06K5_06560	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K06K5_06570	COG2867	negative regulation of translational initiation
K06K5_06580	COG2914	Belongs to the UPF0125 (RnfH) family
K06K5_06590	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K06K5_06610	COG0497	DNA recombination
K06K5_06630	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K06K5_06640	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K06K5_06660	COG1301	dicarboxylic acid transport
K06K5_06680	COG0484	heat shock protein binding
K06K5_06740	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K06K5_06750	COG0590	tRNA wobble adenosine to inosine editing
K06K5_06760	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K06K5_06770	COG0047	phosphoribosylformylglycinamidine synthase activity
K06K5_06770	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K06K5_06830	COG2195	Cleaves the N-terminal amino acid of tripeptides
K06K5_06840	COG2252	PERMEase
K06K5_06850	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K06K5_06880	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K06K5_06890	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K06K5_06900	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K06K5_06910	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K06K5_06910	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K06K5_06960	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K06K5_06970	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K06K5_06980	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K06K5_06990	COG0142	geranyltranstransferase activity
K06K5_07000	COG1722	exodeoxyribonuclease VII activity
K06K5_07010	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K06K5_07030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K06K5_07030	COG0301	tRNA thio-modification
K06K5_07040	COG0583	DNA-binding transcription factor activity
K06K5_07060	COG2363	Small membrane protein
K06K5_07080	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K06K5_07090	COG1611	Belongs to the LOG family
K06K5_07100	COG0745	RESPONSE REGULATOR receiver
K06K5_07100	COG3706	GGDEF domain
K06K5_07120	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K06K5_07120	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K06K5_07140	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
K06K5_07150	COG1464	Belongs to the NlpA lipoprotein family
K06K5_07160	COG2011	ABC-type metal ion transport system permease component
K06K5_07170	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K06K5_07180	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K06K5_07200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K06K5_07200	COG1263	PTS System
K06K5_07210	COG0366	Alpha amylase catalytic
K06K5_07240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K06K5_07250	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K06K5_07260	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K06K5_07270	COG0321	lipoyl(octanoyl) transferase activity
K06K5_07290	COG1686	Belongs to the peptidase S11 family
K06K5_07300	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K06K5_07310	COG0772	Belongs to the SEDS family
K06K5_07320	COG0768	penicillin binding
K06K5_07330	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K06K5_07340	COG0799	negative regulation of ribosome biogenesis
K06K5_07350	COG1466	dna polymerase III delta subunit
K06K5_07360	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
K06K5_07370	COG0495	leucyl-tRNA aminoacylation
K06K5_07380	COG2888	peptidyl-tyrosine sulfation
K06K5_07390	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K06K5_07400	COG4535	Mg2 and Co2 transporter CorC
K06K5_07410	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K06K5_07420	COG1702	phosphate starvation-inducible protein PhoH
K06K5_07430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K06K5_07440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K06K5_07650	COG0012	GTP binding
K06K5_07660	COG0193	aminoacyl-tRNA hydrolase activity
K06K5_07670	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K06K5_07680	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K06K5_07690	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K06K5_07700	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K06K5_07720	COG2890	protein-(glutamine-N5) methyltransferase activity
K06K5_07730	COG3094	Invasion gene expression up-regulator, SirB
K06K5_07740	COG2912	Transglutaminase-like superfamily
K06K5_07750	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K06K5_07760	COG0737	Belongs to the 5'-nucleotidase family
K06K5_07770	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K06K5_07780	COG1187	pseudouridine synthase activity
K06K5_07790	COG2840	Smr protein MutS2
K06K5_07870	COG2217	Heavy metal translocating P-type atpase
K06K5_07870	COG2608	mercury ion transmembrane transporter activity
K06K5_07890	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K06K5_08000	COG0835	chemotaxis
K06K5_08000	COG0784	Response regulator, receiver
K06K5_08010	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K06K5_08020	COG1815	bacterial-type flagellum-dependent cell motility
K06K5_08030	COG1558	bacterial-type flagellum-dependent cell motility
K06K5_08040	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K06K5_08050	COG1749	Flagellar hook protein flgE
K06K5_08060	COG4787	bacterial-type flagellum-dependent cell motility
K06K5_08070	COG4786	Flagellar basal body rod
K06K5_08080	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K06K5_08090	COG1706	bacterial-type flagellum-dependent cell motility
K06K5_08100	COG1705	Flagellar rod assembly protein muramidase FlgJ
K06K5_08100	COG3951	Flagellar rod assembly protein muramidase FlgJ
K06K5_08120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K06K5_08130	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K06K5_08140	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K06K5_08150	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K06K5_08160	COG2190	(PTS) system
K06K5_08170	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K06K5_08190	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K06K5_08200	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K06K5_08210	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
K06K5_08220	COG3115	cell septum assembly
K06K5_08230	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K06K5_08280	COG0330	HflC and HflK could
K06K5_08290	COG2194	sulfuric ester hydrolase activity
K06K5_08330	COG1192	Involved in chromosome partitioning
K06K5_08340	COG1215	transferase activity, transferring glycosyl groups
K06K5_08360	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
K06K5_08370	COG0457	Tetratricopeptide repeat
K06K5_08370	COG3118	belongs to the thioredoxin family
K06K5_08380	COG3118	belongs to the thioredoxin family
K06K5_08390	COG0300	oxidoreductase activity
K06K5_08400	COG1090	epimerase
K06K5_08460	COG0622	Phosphoesterase
K06K5_08500	COG3710	Transcriptional regulator
K06K5_08510	COG0326	Molecular chaperone. Has ATPase activity
K06K5_08530	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K06K5_08540	COG3104	oligopeptide transport
K06K5_08550	COG0250	Participates in transcription elongation, termination and antitermination
K06K5_08560	COG0367	asparagine synthase
K06K5_08570	COG4651	solute:proton antiporter activity
K06K5_08570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K06K5_08580	COG1940	carbohydrate kinase activity
K06K5_08580	COG1846	Transcriptional regulator
K06K5_08590	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K06K5_08600	COG1263	PTS System
K06K5_08600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K06K5_08600	COG2190	(PTS) system
K06K5_08610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K06K5_08620	COG0735	belongs to the Fur family
K06K5_08640	COG0716	FMN binding
K06K5_08660	COG0596	Alpha beta hydrolase
K06K5_08670	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
K06K5_08680	COG0033	Phosphoglucomutase
K06K5_08700	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K06K5_08720	COG2009	succinate dehydrogenase
K06K5_08730	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K06K5_08740	COG1053	succinate dehydrogenase
K06K5_08750	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K06K5_08760	COG0567	Dehydrogenase, E1 component
K06K5_08770	COG0508	dehydrogenase complex catalyzes the overall conversion of
K06K5_08780	COG0045	succinate-CoA ligase (ADP-forming) activity
K06K5_08800	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K06K5_08810	COG1121	(ABC) transporter
K06K5_08820	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
K06K5_08830	COG4977	sequence-specific DNA binding
K06K5_08840	COG1918	ferrous iron import across plasma membrane
K06K5_08890	COG0018	arginyl-trna synthetase
K06K5_08900	COG3102	Protein conserved in bacteria
K06K5_08930	COG0788	formyltetrahydrofolate deformylase activity
K06K5_08940	COG1199	ATP-dependent helicase activity
K06K5_08950	COG1214	PFAM Peptidase M22, glycoprotease
K06K5_08970	COG3065	identical protein binding
K06K5_08980	COG2267	carboxylic ester hydrolase activity
K06K5_08990	COG0318	PFAM AMP-dependent synthetase and ligase
K06K5_09000	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K06K5_09020	COG2894	cell division
K06K5_09030	COG0850	regulation of cytokinetic process
K06K5_09040	COG3100	YcgL domain-containing protein
K06K5_09050	COG2951	lytic endotransglycosylase activity
K06K5_09070	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K06K5_09080	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K06K5_09100	COG2226	methyltransferase
K06K5_09120	COG1028	Short-chain dehydrogenase reductase Sdr
K06K5_09130	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K06K5_09140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K06K5_09190	COG2986	histidine ammonia-lyase
K06K5_09200	COG1216	Glycosyl transferase, family 2
K06K5_09210	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K06K5_09240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K06K5_09250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K06K5_09320	COG0513	Belongs to the DEAD box helicase family
K06K5_09330	COG0569	domain protein
K06K5_09340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K06K5_09380	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K06K5_09390	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K06K5_09400	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K06K5_09410	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K06K5_09450	COG0544	peptidyl-prolyl cis-trans isomerase activity
K06K5_09470	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K06K5_09480	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K06K5_09490	COG0776	regulation of translation
K06K5_09500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K06K5_09510	COG1555	photosystem II stabilization
K06K5_09540	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K06K5_09550	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K06K5_09560	COG0436	Aminotransferase
K06K5_09570	COG1169	isochorismate synthase
K06K5_09580	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K06K5_09600	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K06K5_09610	COG1441	menaquinone biosynthetic process
K06K5_09640	COG2855	membrane
K06K5_09650	COG0477	Major facilitator Superfamily
K06K5_09740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K06K5_09750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K06K5_09780	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K06K5_09790	COG1522	sequence-specific DNA binding
K06K5_09810	COG1946	Acyl-CoA thioesterase
K06K5_09820	COG3126	Type III secretion system lipoprotein chaperone (YscW)
K06K5_09850	COG3706	GGDEF domain
K06K5_09860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K06K5_09870	COG0516	GMP reductase activity
K06K5_09870	COG0517	IMP dehydrogenase activity
K06K5_09920	COG0537	adenosine 5'-monophosphoramidase activity
K06K5_09970	COG3150	esterase
K06K5_09980	COG1252	NADH dehydrogenase
K06K5_10010	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K06K5_10030	COG4591	ABC-type transport system involved in lipoprotein release permease component
K06K5_10040	COG1136	(ABC) transporter
K06K5_10050	COG4591	ABC-type transport system involved in lipoprotein release permease component
K06K5_10070	COG2333	competence protein COMEC
K06K5_10070	COG0658	competence protein
K06K5_10080	COG1132	(ABC) transporter
K06K5_10120	COG2719	SpoVR family
K06K5_10130	COG2718	Belongs to the UPF0229 family
K06K5_10140	COG2766	serine protein kinase
K06K5_10150	COG3013	Belongs to the UPF0304 family
K06K5_10170	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K06K5_10190	COG1882	Formate acetyltransferase
K06K5_10240	COG4215	(ABC) transporter
K06K5_10270	COG0708	Exodeoxyribonuclease III
K06K5_10290	COG3923	Primosomal replication protein n
K06K5_10300	COG0730	response to heat
K06K5_10310	COG1199	ATP-dependent helicase activity
K06K5_10330	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K06K5_10340	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K06K5_10350	COG1187	pseudouridine synthase activity
K06K5_10370	COG1278	Cold shock
K06K5_10380	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K06K5_10390	COG0542	response to heat
K06K5_10400	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K06K5_10410	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K06K5_10420	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K06K5_10460	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K06K5_10470	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K06K5_10480	COG0297	glycogen (starch) synthase activity
K06K5_10520	COG3070	regulator of competence-specific genes
K06K5_10530	COG1609	Transcriptional regulator
K06K5_10540	COG3381	protein complex oligomerization
K06K5_10550	COG0745	RESPONSE REGULATOR receiver
K06K5_10560	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K06K5_10570	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K06K5_10580	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
K06K5_10590	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
K06K5_10600	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K06K5_10640	COG0189	ligase activity
K06K5_10640	COG4067	protein conserved in archaea
K06K5_10650	COG0500	methyltransferase
K06K5_10670	COG1801	Protein of unknown function DUF72
K06K5_10690	COG0217	transcriptional regulatory protein
K06K5_10700	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K06K5_10710	COG0632	four-way junction helicase activity
K06K5_10720	COG2255	four-way junction helicase activity
K06K5_10730	COG1271	oxidase subunit
K06K5_10740	COG1294	oxidase, subunit
K06K5_10750	COG4890	Cyd operon protein YbgT
K06K5_10770	COG0824	Thioesterase
K06K5_10780	COG0811	peptide transport
K06K5_10810	COG0823	Involved in the tonB-independent uptake of proteins
K06K5_10820	COG2885	chlorophyll binding
K06K5_10830	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
K06K5_10840	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K06K5_10860	COG3766	membrane
K06K5_10880	COG0754	glutathionylspermidine amidase activity
K06K5_10900	COG5002	protein histidine kinase activity
K06K5_10900	COG0784	Response regulator, receiver
K06K5_10940	COG1294	oxidase, subunit
K06K5_10950	COG1271	oxidase subunit
K06K5_11000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K06K5_11010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K06K5_11060	COG3568	Endonuclease Exonuclease Phosphatase
K06K5_11110	COG0583	DNA-binding transcription factor activity
K06K5_11130	COG0686	Belongs to the AlaDH PNT family
K06K5_11150	COG1674	ftsk spoiiie
K06K5_11170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K06K5_11210	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K06K5_11220	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K06K5_11260	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K06K5_11300	COG0300	oxidoreductase activity
K06K5_11330	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K06K5_11350	COG2268	Band 7 protein
K06K5_11370	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K06K5_11380	COG2915	High frequency lysogenization protein hflD homolog
K06K5_11410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K06K5_11430	COG1757	Na H antiporter
K06K5_11450	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K06K5_11470	COG0131	Imidazoleglycerol-phosphate dehydratase
K06K5_11470	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K06K5_11480	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K06K5_11490	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K06K5_11500	COG0107	imidazoleglycerol-phosphate synthase activity
K06K5_11510	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K06K5_11510	COG0140	phosphoribosyl-ATP diphosphatase activity
K06K5_11520	COG3012	SEC-C Motif Domain Protein
K06K5_11530	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K06K5_11540	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K06K5_11550	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K06K5_11560	COG0215	cysteine-tRNA ligase activity
K06K5_11570	COG1435	thymidine kinase activity
K06K5_11630	COG2116	formate transmembrane transporter activity
K06K5_11650	COG0390	transport system, permease component
K06K5_11660	COG4459	periplasmic nitrate reductase
K06K5_11670	COG3005	denitrification pathway
K06K5_11680	COG0243	molybdopterin cofactor binding
K06K5_11710	COG1227	inorganic diphosphatase activity
K06K5_11730	COG4172	Belongs to the ABC transporter superfamily
K06K5_11750	COG4171	peptide transport system, permease
K06K5_11760	COG4168	peptide transport system, permease
K06K5_11780	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K06K5_11790	COG1842	Phage shock protein A
K06K5_11810	COG1983	PspC domain protein
K06K5_11850	COG2818	Glycosylase
K06K5_11860	COG5380	lipid catabolic process
K06K5_11870	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
K06K5_11880	COG0626	cystathionine gamma-synthase activity
K06K5_11900	COG0733	neurotransmitter:sodium symporter activity
K06K5_11910	COG0564	pseudouridine synthase activity
K06K5_11930	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K06K5_11940	COG1151	hydroxylamine reductase activity
K06K5_11950	COG3604	Transcriptional regulator
K06K5_11970	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K06K5_11980	COG4136	ATPase activity
K06K5_11990	COG4135	transport system, permease component
K06K5_12000	COG4134	Bacterial extracellular solute-binding protein
K06K5_12020	COG3313	Fe-S protein
K06K5_12060	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K06K5_12070	COG2205	protein histidine kinase activity
K06K5_12080	COG0745	RESPONSE REGULATOR receiver
K06K5_12100	COG1061	Type III restriction enzyme res subunit
K06K5_12110	COG1187	pseudouridine synthase activity
K06K5_12120	COG2814	Major facilitator Superfamily
K06K5_12140	COG0702	epimerase
K06K5_12150	COG0534	Mate efflux family protein
K06K5_12190	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K06K5_12210	COG1960	acyl-CoA dehydrogenase activity
K06K5_12220	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K06K5_12230	COG3273	potassium ion transport
K06K5_12230	COG2985	domain, Protein
K06K5_12240	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K06K5_12270	COG1737	Transcriptional regulator
K06K5_12280	COG0076	glutamate decarboxylase activity
K06K5_12300	COG2431	L-lysine efflux transmembrane transporter activity
K06K5_12320	COG3070	regulator of competence-specific genes
K06K5_12360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K06K5_12360	COG4191	Histidine kinase
K06K5_12380	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K06K5_12400	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K06K5_12410	COG4988	ABC transporter
K06K5_12420	COG0492	ferredoxin-NADP+ reductase activity
K06K5_12460	COG0745	RESPONSE REGULATOR receiver
K06K5_12460	COG3706	GGDEF domain
K06K5_12470	COG0471	metal ion transport
K06K5_12480	COG2949	membrane
K06K5_12490	COG0281	malic enzyme
K06K5_12500	COG1643	Atp-dependent helicase
K06K5_12530	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K06K5_12600	COG0277	FAD linked oxidase domain protein
K06K5_12600	COG0247	lactate metabolic process
K06K5_12630	COG2986	histidine ammonia-lyase
K06K5_12640	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K06K5_12650	COG0010	Belongs to the arginase family
K06K5_12660	COG1228	amidohydrolase
K06K5_12700	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K06K5_12720	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K06K5_12740	COG0393	Putative heavy-metal-binding
K06K5_12810	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K06K5_12820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K06K5_12820	COG0072	phenylalanine-tRNA ligase activity
K06K5_12840	COG0776	regulation of translation
K06K5_12860	COG0500	methyltransferase
K06K5_12870	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K06K5_12880	COG0295	cytidine deaminase activity
K06K5_12890	COG1346	cytolysis
K06K5_12900	COG1380	Effector of murein hydrolase LrgA
K06K5_12910	COG2925	Exonuclease
K06K5_13030	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K06K5_13090	COG1484	DNA-dependent DNA replication
K06K5_13390	COG0702	epimerase
K06K5_13400	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K06K5_13410	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K06K5_13450	COG2988	succinylglutamate desuccinylase activity
K06K5_13460	COG4139	cobalamin transport
K06K5_13470	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
K06K5_13510	COG0583	DNA-binding transcription factor activity
K06K5_13530	COG1451	nucleotide metabolic process
K06K5_13540	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
K06K5_13600	COG3938	Belongs to the proline racemase family
K06K5_13630	COG2423	ornithine cyclodeaminase activity
K06K5_13640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K06K5_13650	COG3842	ATPase activity
K06K5_13660	COG1176	ABC-type spermidine putrescine transport system, permease component I
K06K5_13670	COG1177	transmembrane transport
K06K5_13690	COG3291	Pkd domain containing protein
K06K5_13720	COG0444	Belongs to the ABC transporter superfamily
K06K5_13730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K06K5_13740	COG0601	transmembrane transport
K06K5_13760	COG2195	Cleaves the N-terminal amino acid of tripeptides
K06K5_13780	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K06K5_13800	COG0625	glutathione transferase activity
K06K5_13900	COG3755	Protein conserved in bacteria
K06K5_13950	COG1742	UPF0060 membrane protein
K06K5_13980	COG1757	Na H antiporter
K06K5_13990	COG0174	glutamine synthetase
K06K5_14000	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K06K5_14010	COG1396	sequence-specific DNA binding
K06K5_14010	COG1917	Cupin 2, conserved barrel domain protein
K06K5_14020	COG1012	belongs to the aldehyde dehydrogenase family
K06K5_14030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K06K5_14050	COG2957	Belongs to the agmatine deiminase family
K06K5_14060	COG1012	belongs to the aldehyde dehydrogenase family
K06K5_14070	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K06K5_14080	COG2200	EAL domain
K06K5_14100	COG1846	Transcriptional regulator
K06K5_14110	COG2315	Protein conserved in bacteria
K06K5_14190	COG3063	Type IV pilus biogenesis stability protein PilW
K06K5_14200	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K06K5_14230	COG1560	Kdo2-lipid A biosynthetic process
K06K5_14250	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K06K5_14500	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K06K5_14510	COG1280	lysine exporter protein (LysE YggA)
K06K5_14530	COG1115	amino acid carrier protein
K06K5_14580	COG1368	sulfuric ester hydrolase activity
K06K5_14590	COG2113	Glycine betaine
K06K5_14600	COG4176	ABC-type proline glycine betaine transport system permease component
K06K5_14610	COG4175	Glycine betaine
K06K5_14640	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K06K5_14650	COG0456	acetyltransferase
K06K5_14660	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K06K5_14670	COG0662	Cupin 2, conserved barrel domain protein
K06K5_14680	COG0527	aspartate kinase activity
K06K5_14690	COG3119	arylsulfatase activity
K06K5_14720	COG0641	radical SAM
K06K5_14750	COG3119	arylsulfatase activity
K06K5_14800	COG1538	Outer membrane efflux protein
K06K5_14830	COG1349	DNA-binding transcription factor activity
K06K5_14840	COG0673	inositol 2-dehydrogenase activity
K06K5_14850	COG4702	Belongs to the UPF0303 family
K06K5_14860	COG0745	RESPONSE REGULATOR receiver
K06K5_14860	COG3706	GGDEF domain
K06K5_14900	COG0471	metal ion transport
K06K5_14930	COG3300	MHYT domain
K06K5_14930	COG5001	Diguanylate cyclase
K06K5_14960	COG1328	CTP reductase activity
K06K5_14970	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K06K5_14990	COG0861	Integral membrane protein TerC family
K06K5_15010	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K06K5_15030	COG0814	amino acid
K06K5_15060	COG1120	ATPase activity
K06K5_15070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K06K5_15090	COG4774	siderophore transport
K06K5_15110	COG1132	(ABC) transporter
K06K5_15120	COG1132	(ABC) transporter
K06K5_15150	COG0583	DNA-binding transcription factor activity
K06K5_15200	COG0443	Heat shock 70 kDa protein
K06K5_15210	COG0443	Heat shock 70 kDa protein
K06K5_15310	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K06K5_15320	COG1643	Atp-dependent helicase
K06K5_15350	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K06K5_15370	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K06K5_15380	COG1215	transferase activity, transferring glycosyl groups
K06K5_15390	COG0438	transferase activity, transferring glycosyl groups
K06K5_15450	COG0438	transferase activity, transferring glycosyl groups
K06K5_15460	COG0438	transferase activity, transferring glycosyl groups
K06K5_15470	COG2204	response regulator
K06K5_15540	COG1793	dna ligase
K06K5_15560	COG0534	Mate efflux family protein
K06K5_15570	COG0307	riboflavin synthase, alpha
K06K5_15610	COG3706	GGDEF domain
K06K5_15630	COG0791	NLP P60 protein
K06K5_15710	COG1940	carbohydrate kinase activity
K06K5_15740	COG0746	molybdenum cofactor guanylyltransferase activity
K06K5_15750	COG3842	ATPase activity
K06K5_15780	COG2204	response regulator
K06K5_15790	COG4191	Histidine kinase
K06K5_15800	COG0488	(ABC) transporter
K06K5_15820	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K06K5_15860	COG3381	protein complex oligomerization
K06K5_15880	COG0243	molybdopterin cofactor binding
K06K5_15880	COG3383	formate dehydrogenase (NAD+) activity
K06K5_15890	COG0437	4 iron, 4 sulfur cluster binding
K06K5_15940	COG0004	ammonium transporteR
K06K5_15960	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K06K5_15970	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K06K5_15980	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K06K5_15990	COG1177	transmembrane transport
K06K5_16000	COG1176	ABC-type spermidine putrescine transport system, permease component I
K06K5_16010	COG3842	ATPase activity
K06K5_16060	COG0589	response to stress
K06K5_16070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K06K5_16100	COG2217	Heavy metal translocating P-type atpase
K06K5_16120	COG2010	Cytochrome c
K06K5_16150	COG3278	Belongs to the heme-copper respiratory oxidase family
K06K5_16180	COG2205	protein histidine kinase activity
K06K5_16180	COG0784	Response regulator, receiver
K06K5_16210	COG3120	sequence-specific DNA binding
K06K5_16220	COG1067	ATP-dependent peptidase activity
K06K5_16230	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K06K5_16280	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K06K5_16280	COG0116	Belongs to the methyltransferase superfamily
K06K5_16300	COG0167	dihydroorotate dehydrogenase activity
K06K5_16310	COG2902	Dehydrogenase
K06K5_16320	COG0308	aminopeptidase N
K06K5_16350	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
K06K5_16360	COG1956	GAF domain-containing protein
K06K5_16370	COG1132	(ABC) transporter
K06K5_16380	COG2995	paraquat-inducible protein a
K06K5_16390	COG3008	intermembrane lipid transfer
K06K5_16440	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K06K5_16450	COG1666	GTP binding
K06K5_16470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K06K5_16490	COG4597	amino acid ABC transporter
K06K5_16500	COG0765	amino acid transport
K06K5_16510	COG1126	abc transporter atp-binding protein
K06K5_16520	COG0670	Belongs to the BI1 family
K06K5_16540	COG2920	part of a sulfur-relay system
K06K5_16550	COG1254	Belongs to the acylphosphatase family
K06K5_16560	COG0840	transmembrane signaling receptor activity
K06K5_16600	COG2885	chlorophyll binding
K06K5_16650	COG2203	Gaf domain
K06K5_16650	COG2199	diguanylate cyclase activity
K06K5_16660	COG1414	Transcriptional regulator
K06K5_16680	COG0656	L-ascorbic acid biosynthetic process
K06K5_16690	COG0583	DNA-binding transcription factor activity
K06K5_16710	COG0583	DNA-binding transcription factor activity
K06K5_16720	COG2814	Major facilitator Superfamily
K06K5_16760	COG1335	isochorismatase
K06K5_16770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K06K5_16800	COG0646	methionine synthase
K06K5_16800	COG1410	methionine synthase
K06K5_16810	COG1126	abc transporter atp-binding protein
K06K5_16820	COG0765	amino acid transport
K06K5_16830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K06K5_16870	COG0583	DNA-binding transcription factor activity
K06K5_16900	COG0583	DNA-binding transcription factor activity
K06K5_16920	COG0583	DNA-binding transcription factor activity
K06K5_16950	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K06K5_16960	COG0602	queuosine metabolic process
K06K5_16970	COG0561	phosphatase activity
K06K5_17020	COG2828	Protein conserved in bacteria
K06K5_17040	COG0372	Belongs to the citrate synthase family
K06K5_17050	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K06K5_17120	COG0730	response to heat
K06K5_17160	COG0457	Tetratricopeptide repeat
K06K5_17290	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K06K5_17300	COG4790	Type iii secretion
K06K5_17310	COG4794	Type iii secretion
K06K5_17320	COG4791	protein targeting
K06K5_17330	COG4792	protein secretion
K06K5_17340	COG2207	Transcriptional regulator
K06K5_17400	COG3177	Filamentation induced by cAMP protein fic
K06K5_17440	COG4669	(LipO)protein
K06K5_17580	COG1012	belongs to the aldehyde dehydrogenase family
K06K5_17590	COG3284	Transcriptional regulator
K06K5_17620	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K06K5_17630	COG0363	glucosamine-6-phosphate deaminase activity
K06K5_17640	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K06K5_17650	COG2207	Transcriptional regulator
K06K5_17670	COG4565	transcriptional regulatory protein
K06K5_17680	COG3290	protein histidine kinase activity
K06K5_17710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K06K5_17770	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K06K5_17790	COG2985	domain, Protein
K06K5_17860	COG2272	Belongs to the type-B carboxylesterase lipase family
K06K5_17890	COG0729	surface antigen
K06K5_17910	COG1280	lysine exporter protein (LysE YggA)
K06K5_17920	COG1280	lysine exporter protein (LysE YggA)
K06K5_17930	COG5507	3-demethylubiquinone-9 3-methyltransferase
K06K5_17970	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K06K5_17990	COG0110	maltose O-acetyltransferase activity
K06K5_18070	COG2801	Transposase and inactivated derivatives
K06K5_18120	COG1683	Conserved Protein
K06K5_18240	COG2801	Transposase and inactivated derivatives
K06K5_18290	COG1403	HNH endonuclease
K06K5_18420	COG4974	Belongs to the 'phage' integrase family
K06K5_18450	COG3706	GGDEF domain
K06K5_18470	COG2985	domain, Protein
K06K5_18480	COG0076	glutamate decarboxylase activity
K06K5_18490	COG0598	Magnesium transport protein CorA
K06K5_18510	COG0387	Pfam Sodium calcium exchanger
K06K5_18520	COG0387	Pfam Sodium calcium exchanger
K06K5_18550	COG1289	transmembrane transporter activity
K06K5_18580	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K06K5_18600	COG2985	domain, Protein
K06K5_18610	COG0025	NhaP-type Na H and K H
K06K5_18630	COG2433	Pfam Transposase IS66
K06K5_18650	COG3302	dmso reductase anchor subunit
K06K5_18660	COG0437	4 iron, 4 sulfur cluster binding
K06K5_18670	COG0243	molybdopterin cofactor binding
K06K5_18690	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K06K5_18690	COG2221	Nitrite and sulphite reductase 4Fe-4S
K06K5_18700	COG2205	protein histidine kinase activity
K06K5_18700	COG0784	Response regulator, receiver
K06K5_18790	COG2204	response regulator
K06K5_18840	COG3477	response to acidic pH
K06K5_18850	COG2200	EAL domain
K06K5_18850	COG3287	FIST C domain
K06K5_18850	COG2199	diguanylate cyclase activity
K06K5_18860	COG2197	response regulator
K06K5_19000	COG1472	Belongs to the glycosyl hydrolase 3 family
K06K5_19020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K06K5_19020	COG2205	protein histidine kinase activity
K06K5_19030	COG2197	response regulator
K06K5_19150	COG1335	isochorismatase
K06K5_19280	COG4628	conserved protein (DUF2132)
K06K5_19340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K06K5_19360	COG3768	UPF0283 membrane protein
K06K5_19370	COG3106	COG3106 Predicted ATPase
K06K5_19400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K06K5_19410	COG2205	protein histidine kinase activity
K06K5_19410	COG0784	Response regulator, receiver
K06K5_19430	COG0494	nUDIX hydrolase
K06K5_19440	COG0814	amino acid
K06K5_19450	COG1760	l-serine dehydratase
K06K5_19460	COG2200	EAL domain
K06K5_19480	COG0720	synthase
K06K5_19490	COG0840	transmembrane signaling receptor activity
K06K5_19500	COG0017	Asparaginyl-tRNA synthetase
K06K5_19520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K06K5_19550	COG1448	Aminotransferase
K06K5_19590	COG0840	transmembrane signaling receptor activity
K06K5_19600	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K06K5_19660	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K06K5_19690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K06K5_19700	COG3108	Peptidase M15
K06K5_19710	COG2989	Protein conserved in bacteria
K06K5_19760	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K06K5_19780	COG4235	cytochrome complex assembly
K06K5_19780	COG3088	subunit of a heme lyase
K06K5_19800	COG1138	Cytochrome C-type biogenesis protein
K06K5_19810	COG3301	Polysulphide reductase, NrfD
K06K5_19820	COG0437	4 iron, 4 sulfur cluster binding
K06K5_19840	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
K06K5_19880	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K06K5_19890	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K06K5_19900	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K06K5_19950	COG0019	diaminopimelate decarboxylase activity
K06K5_20030	COG0322	excinuclease ABC activity
K06K5_20040	COG2197	response regulator
K06K5_20050	COG0417	DNA replication proofreading
K06K5_20090	COG1187	pseudouridine synthase activity
K06K5_20110	COG0009	L-threonylcarbamoyladenylate synthase
K06K5_20120	COG0613	PHP domain protein
K06K5_20140	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K06K5_20150	COG0512	Glutamine amidotransferase of anthranilate synthase
K06K5_20170	COG0134	indole-3-glycerol-phosphate synthase activity
K06K5_20170	COG0135	phosphoribosylanthranilate isomerase activity
K06K5_20190	COG0159	tryptophan synthase activity
K06K5_20200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K06K5_20210	COG0318	PFAM AMP-dependent synthetase and ligase
K06K5_20220	COG1301	dicarboxylic acid transport
K06K5_20260	COG2917	probably involved in intracellular septation
K06K5_20270	COG1607	acyl-coa hydrolase
K06K5_20280	COG2350	Protein conserved in bacteria
K06K5_20300	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K06K5_20310	COG0583	DNA-binding transcription factor activity
K06K5_20340	COG5001	Diguanylate cyclase
K06K5_20350	COG1032	radical SAM domain protein
K06K5_20390	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K06K5_20400	COG0463	Glycosyl transferase, family 2
K06K5_20410	COG0745	RESPONSE REGULATOR receiver
K06K5_20420	COG3850	Histidine kinase
K06K5_20420	COG5002	protein histidine kinase activity
K06K5_20480	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K06K5_20520	COG1136	(ABC) transporter
K06K5_20520	COG0577	efflux transmembrane transporter activity
K06K5_20530	COG0577	efflux transmembrane transporter activity
K06K5_20530	COG1136	(ABC) transporter
K06K5_20540	COG0577	efflux transmembrane transporter activity
K06K5_20540	COG1136	(ABC) transporter
K06K5_20560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K06K5_20610	COG3118	belongs to the thioredoxin family
K06K5_20620	COG4232	protein-disulfide reductase activity
K06K5_20690	COG2863	cytochrome
K06K5_20700	COG3258	Cytochrome c
K06K5_20710	COG2995	paraquat-inducible protein a
K06K5_20720	COG3008	intermembrane lipid transfer
K06K5_20720	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K06K5_20760	COG4166	transmembrane transport
K06K5_20780	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K06K5_20790	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
K06K5_20810	COG0539	negative regulation of cytoplasmic translation
K06K5_20820	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K06K5_20830	COG0616	signal peptide processing
K06K5_20840	COG1028	Short-chain dehydrogenase reductase Sdr
K06K5_20870	COG0587	DNA-directed DNA polymerase activity
K06K5_20880	COG0835	chemotaxis
K06K5_20880	COG0784	Response regulator, receiver
K06K5_20890	COG1940	carbohydrate kinase activity
K06K5_20900	COG0469	pyruvate kinase activity
K06K5_20910	COG4667	esterase of the alpha-beta hydrolase superfamily
K06K5_20940	COG0733	neurotransmitter:sodium symporter activity
K06K5_20970	COG1263	PTS System
K06K5_20970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K06K5_20980	COG0084	hydrolase, TatD family'
K06K5_20990	COG0470	DNA polymerase III
K06K5_21000	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K06K5_21010	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K06K5_21070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K06K5_21080	COG0416	fatty acid biosynthetic process
K06K5_21100	COG1399	metal-binding, possibly nucleic acid-binding protein
K06K5_21110	COG0424	maF-like protein
K06K5_21120	COG0564	pseudouridine synthase activity
K06K5_21130	COG1530	ribonuclease E activity
K06K5_21140	COG0659	secondary active sulfate transmembrane transporter activity
K06K5_21150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K06K5_21160	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
K06K5_21180	COG0572	uridine kinase
K06K5_21200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K06K5_21200	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K06K5_21240	COG2186	Transcriptional regulator
K06K5_21250	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K06K5_21260	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K06K5_21270	COG3318	Belongs to the UPF0149 family
K06K5_21270	COG3012	SEC-C Motif Domain Protein
K06K5_21280	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K06K5_21290	COG3706	GGDEF domain
K06K5_21300	COG0366	Alpha amylase catalytic
K06K5_21310	COG1122	ATPase activity
K06K5_21320	COG4120	Belongs to the binding-protein-dependent transport system permease family
K06K5_21340	COG3092	negative regulation of chromosome organization
K06K5_21350	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K06K5_21360	COG0857	belongs to the CobB CobQ family
K06K5_21360	COG0280	phosphate acetyltransferase
K06K5_21380	COG0435	Glutathione S-transferase
K06K5_21400	COG0444	Belongs to the ABC transporter superfamily
K06K5_21410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K06K5_21420	COG0601	transmembrane transport
K06K5_21440	COG0314	molybdopterin synthase activity
K06K5_21450	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K06K5_21460	COG0315	cyclic pyranopterin monophosphate synthase activity
K06K5_21470	COG0521	Mo-molybdopterin cofactor biosynthetic process
K06K5_21480	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K06K5_21490	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K06K5_21500	COG2198	Histidine kinase
K06K5_21510	COG2204	response regulator
K06K5_21520	COG0556	nucleotide-excision repair
K06K5_21540	COG1882	Formate acetyltransferase
K06K5_21550	COG4657	Part of a membrane complex involved in electron transport
K06K5_21560	COG2878	Part of a membrane complex involved in electron transport
K06K5_21570	COG4656	Part of a membrane complex involved in electron transport
K06K5_21580	COG4658	electron transport chain
K06K5_21590	COG4659	FMN binding
K06K5_21600	COG4660	Part of a membrane complex involved in electron transport
K06K5_21610	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K06K5_21620	COG0346	lactoylglutathione lyase activity
K06K5_21640	COG2885	chlorophyll binding
K06K5_21650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K06K5_21660	COG2056	Na+-H+ antiporter family
K06K5_21700	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K06K5_21740	COG1454	alcohol dehydrogenase
K06K5_21740	COG1012	belongs to the aldehyde dehydrogenase family
K06K5_21750	COG2095	MarC family integral membrane protein
K06K5_21760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K06K5_21770	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K06K5_21780	COG1757	Na H antiporter
K06K5_21810	COG3081	Nucleoid-associated protein
K06K5_21820	COG3082	Protein of unknown function (DUF1414)
K06K5_21830	COG3083	sulfuric ester hydrolase activity
K06K5_21850	COG0123	including yeast histone deacetylase and acetoin utilization protein
K06K5_21880	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K06K5_21890	COG0778	Nitroreductase
K06K5_21910	COG1902	pentaerythritol trinitrate reductase activity
K06K5_21910	COG0446	pyridine nucleotide-disulphide oxidoreductase
K06K5_21920	COG0616	signal peptide processing
K06K5_21930	COG0252	asparaginase activity
K06K5_21940	COG3139	Protein of unknown function (DUF1315)
K06K5_21960	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K06K5_21970	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K06K5_22000	COG2226	methyltransferase
K06K5_22030	COG1785	Belongs to the alkaline phosphatase family
K06K5_22050	COG0346	lactoylglutathione lyase activity
K06K5_22060	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
K06K5_22070	COG0668	transmembrane transport
K06K5_22080	COG2983	Belongs to the UPF0260 family
K06K5_22090	COG2261	transglycosylase associated protein
K06K5_22110	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K06K5_22120	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K06K5_22130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K06K5_22150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K06K5_22160	COG2832	Protein of unknown function (DUF454)
K06K5_22180	COG0745	RESPONSE REGULATOR receiver
K06K5_22190	COG0583	DNA-binding transcription factor activity
K06K5_22200	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K06K5_22210	COG1286	toxin biosynthetic process
K06K5_22220	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
K06K5_22230	COG0285	dihydrofolate synthase activity
K06K5_22240	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K06K5_22250	COG0101	tRNA pseudouridine synthase activity
K06K5_22270	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K06K5_22280	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K06K5_22290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K06K5_22300	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K06K5_22300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K06K5_22310	COG0431	NADPH-dependent FMN reductase
K06K5_22330	COG3101	peptidyl-lysine hydroxylation
K06K5_22340	COG2860	membrane
K06K5_22350	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K06K5_22360	COG2890	protein-(glutamine-N5) methyltransferase activity
K06K5_22370	COG2840	Smr protein MutS2
K06K5_22380	COG2062	phosphohistidine phosphatase, SixA
K06K5_22410	COG1250	3-hydroxyacyl-CoA dehydrogenase
K06K5_22410	COG1024	Enoyl-CoA hydratase
K06K5_22420	COG0183	Belongs to the thiolase family
K06K5_22470	COG2067	long-chain fatty acid transport protein
K06K5_22490	COG4235	cytochrome complex assembly
K06K5_22490	COG3088	subunit of a heme lyase
K06K5_22510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K06K5_22520	COG1138	Cytochrome C-type biogenesis protein
K06K5_22530	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K06K5_22540	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K06K5_22550	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K06K5_22560	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K06K5_22570	COG4133	protoheme IX ABC transporter activity
K06K5_22590	COG0835	chemotaxis
K06K5_22610	COG1192	Involved in chromosome partitioning
K06K5_22620	COG2201	protein-glutamate methylesterase activity
K06K5_22630	COG0643	Histidine kinase
K06K5_22630	COG2198	Histidine kinase
K06K5_22640	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
K06K5_22670	COG0455	bacterial-type flagellum organization
K06K5_22710	COG1684	flagellar biosynthetic protein fliR
K06K5_22720	COG1987	bacterial-type flagellum assembly
K06K5_22830	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K06K5_22850	COG1677	Flagellar hook-basal body complex protein FliE
K06K5_22860	COG2204	response regulator
K06K5_22870	COG4191	Histidine kinase
K06K5_22880	COG2204	response regulator
K06K5_22890	COG1516	flagellar protein fliS
K06K5_22910	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K06K5_22920	COG1334	flagellar protein FlaG
K06K5_22930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K06K5_22940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K06K5_22950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K06K5_22960	COG2837	iron assimilation
K06K5_23010	COG1393	Belongs to the ArsC family
K06K5_23020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K06K5_23060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K06K5_23080	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K06K5_23130	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K06K5_23150	COG1053	succinate dehydrogenase
K06K5_23280	COG0210	DNA helicase
K06K5_23320	COG2963	transposase activity
K06K5_23350	COG1278	Cold shock
K06K5_23400	COG1278	Cold shock
K06K5_23410	COG4974	Belongs to the 'phage' integrase family
K06K5_23420	COG0330	HflC and HflK could
K06K5_23460	COG1278	Cold shock
K06K5_23490	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K06K5_23520	COG4783	chaperone-mediated protein folding
K06K5_23530	COG1393	Belongs to the ArsC family
K06K5_23570	COG2233	PERMEase
K06K5_23580	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K06K5_23590	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K06K5_23600	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K06K5_23620	COG0121	glutamine amidotransferase
K06K5_23630	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K06K5_23640	COG1960	acyl-CoA dehydrogenase activity
K06K5_23700	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K06K5_23710	COG0328	RNA-DNA hybrid ribonuclease activity
K06K5_23720	COG2226	methyltransferase
K06K5_23730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K06K5_23740	COG1388	LysM domain
K06K5_23740	COG0741	lytic transglycosylase activity
K06K5_23760	COG3021	interspecies interaction between organisms
K06K5_23770	COG0347	Belongs to the P(II) protein family
K06K5_23800	COG0825	malonyl-CoA metabolic process
K06K5_23810	COG0587	DNA-directed DNA polymerase activity
K06K5_23830	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K06K5_23840	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K06K5_23860	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K06K5_23870	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
K06K5_23890	COG0750	zinc metalloprotease
K06K5_23900	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K06K5_23910	COG0575	Belongs to the CDS family
K06K5_23920	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K06K5_23930	COG0233	cytoplasmic translational termination
K06K5_23940	COG0528	UMP kinase activity
K06K5_23950	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K06K5_23960	COG0052	Belongs to the universal ribosomal protein uS2 family
K06K5_23970	COG0024	Methionine aminopeptidase
K06K5_23980	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K06K5_24000	COG0564	pseudouridine synthase activity
K06K5_24010	COG3098	single-species biofilm formation
K06K5_24070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K06K5_24080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K06K5_24130	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K06K5_24140	COG0254	rRNA binding
K06K5_24150	COG1720	tRNA m6t6A37 methyltransferase activity
K06K5_24160	COG0442	prolyl-tRNA aminoacylation
K06K5_24200	COG0733	neurotransmitter:sodium symporter activity
K06K5_24230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K06K5_24240	COG0514	ATP-dependent DNA helicase (RecQ)
K06K5_24290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K06K5_24450	COG0659	secondary active sulfate transmembrane transporter activity
K06K5_24460	COG0589	response to stress
K06K5_24470	COG0519	Catalyzes the synthesis of GMP from XMP
K06K5_24570	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K06K5_24590	COG0745	RESPONSE REGULATOR receiver
K06K5_24590	COG3706	GGDEF domain
K06K5_24610	COG1477	protein flavinylation
K06K5_24620	COG2871	sodium ion transport
K06K5_24630	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K06K5_24640	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K06K5_24650	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K06K5_24660	COG1805	sodium ion transport
K06K5_24670	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K06K5_24680	COG0271	Belongs to the BolA IbaG family
K06K5_24690	COG2813	Specifically methylates the guanine in position
K06K5_24700	COG3056	Lipoprotein
K06K5_24740	COG1595	DNA-templated transcription, initiation
K06K5_24780	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K06K5_24790	COG0693	protein deglycase activity
K06K5_24800	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K06K5_24810	COG3706	GGDEF domain
K06K5_24820	COG2166	iron-sulfur cluster assembly
K06K5_24830	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K06K5_24840	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
K06K5_24860	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K06K5_24860	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K06K5_24880	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K06K5_24890	COG1074	ATP-dependent DNA helicase activity
K06K5_24900	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K06K5_25000	COG0270	DNA (cytosine-5-)-methyltransferase activity
K06K5_25050	COG3141	response to X-ray
K06K5_25080	COG2171	N-acyltransferase activity
K06K5_25090	COG0584	glycerophosphoryl diester phosphodiesterase
K06K5_25100	COG2271	Major facilitator Superfamily
K06K5_25110	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K06K5_25120	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K06K5_25130	COG1349	DNA-binding transcription factor activity
K06K5_25140	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K06K5_25150	COG0598	Magnesium transport protein CorA
K06K5_25190	COG1609	Transcriptional regulator
K06K5_25200	COG0583	DNA-binding transcription factor activity
K06K5_25280	COG1022	Amp-dependent synthetase and ligase
K06K5_25300	COG0583	DNA-binding transcription factor activity
K06K5_25310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K06K5_25320	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K06K5_25340	COG0560	Phosphoserine phosphatase
K06K5_25360	COG0813	purine-nucleoside phosphorylase activity
K06K5_25370	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K06K5_25380	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K06K5_25390	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K06K5_25400	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K06K5_25410	COG0084	hydrolase, TatD family'
K06K5_25470	COG3153	acetyltransferase
K06K5_25520	COG0534	Mate efflux family protein
K06K5_25550	COG1185	polyribonucleotide nucleotidyltransferase activity
K06K5_25560	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K06K5_25570	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K06K5_25580	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K06K5_25590	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K06K5_25600	COG0195	Participates in both transcription termination and antitermination
K06K5_25610	COG0779	Required for maturation of 30S ribosomal subunits
K06K5_25640	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K06K5_25650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K06K5_25660	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K06K5_25670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K06K5_25680	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K06K5_25690	COG1534	Rna-binding protein
K06K5_25700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K06K5_25710	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K06K5_25720	COG2027	D-alanyl-D-alanine carboxypeptidase
K06K5_25740	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K06K5_25750	COG0739	heme binding
K06K5_25800	COG0628	permease
K06K5_25830	COG0747	negative chemotaxis
K06K5_25850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K06K5_25860	COG0444	Belongs to the ABC transporter superfamily
K06K5_25870	COG4608	Belongs to the ABC transporter superfamily
K06K5_25890	COG2971	BadF BadG BcrA BcrD
K06K5_25920	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K06K5_25930	COG3842	ATPase activity
K06K5_25950	COG1840	ABC-type Fe3 transport system, periplasmic component
K06K5_25960	COG0004	ammonium transporteR
K06K5_25980	COG3112	Uncharacterised protein family (UPF0231)
K06K5_25990	COG1049	propionate catabolic process, 2-methylcitrate cycle
K06K5_26000	COG1752	Esterase of the alpha-beta hydrolase superfamily
K06K5_26010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K06K5_26020	COG1643	Atp-dependent helicase
K06K5_26030	COG1489	DNA binding
K06K5_26040	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K06K5_26050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K06K5_26070	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K06K5_26080	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K06K5_26090	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K06K5_26100	COG1560	Kdo2-lipid A biosynthetic process
K06K5_26110	COG0842	Transport permease protein
K06K5_26120	COG1131	(ABC) transporter
K06K5_26130	COG0659	secondary active sulfate transmembrane transporter activity
K06K5_26140	COG0288	reversible hydration of carbon dioxide
K06K5_26170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K06K5_26180	COG0508	dehydrogenase complex catalyzes the overall conversion of
K06K5_26190	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K06K5_26200	COG2186	Transcriptional regulator
K06K5_26220	COG0157	Belongs to the NadC ModD family
K06K5_26230	COG4969	Belongs to the N-Me-Phe pilin family
K06K5_26240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K06K5_26250	COG1459	type II secretion system
K06K5_26270	COG0237	dephospho-CoA kinase activity
K06K5_26280	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
K06K5_26290	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K06K5_26320	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K06K5_26330	COG0228	four-way junction DNA binding
K06K5_26340	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K06K5_26350	COG4137	Cytochrome C assembly protein
K06K5_26360	COG4536	flavin adenine dinucleotide binding
K06K5_26370	COG1854	S-ribosylhomocysteine lyase activity
K06K5_26400	COG0612	Peptidase, M16
K06K5_26410	COG1238	metal cluster binding
K06K5_26430	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K06K5_26440	COG0511	ligase activity, forming carbon-carbon bonds
K06K5_26440	COG5016	pyruvate
K06K5_26570	COG0527	aspartate kinase activity
K06K5_26580	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K06K5_26590	COG2137	regulation of response to DNA damage stimulus
K06K5_26600	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K06K5_26610	COG1546	Belongs to the CinA family
K06K5_26620	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K06K5_26630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K06K5_26650	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K06K5_26660	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K06K5_26680	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K06K5_26690	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K06K5_26700	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K06K5_26710	COG0148	phosphopyruvate hydratase activity
K06K5_26720	COG0504	CTP synthase activity
K06K5_26730	COG3956	TIGRFAM MazG family protein
K06K5_26750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K06K5_26760	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K06K5_26780	COG0736	holo-[acyl-carrier-protein] synthase activity
K06K5_26790	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K06K5_26800	COG1381	Involved in DNA repair and RecF pathway recombination
K06K5_26810	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K06K5_26830	COG0681	Belongs to the peptidase S26 family
K06K5_26840	COG0481	GTPase activity
K06K5_26850	COG3086	response to oxidative stress
K06K5_26880	COG1595	DNA-templated transcription, initiation
K06K5_26890	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K06K5_26910	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K06K5_26950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K06K5_26960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K06K5_26970	COG3079	Belongs to the UPF0149 family
K06K5_26980	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K06K5_26990	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K06K5_27000	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K06K5_27010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K06K5_27030	COG0583	DNA-binding transcription factor activity
K06K5_27060	COG0668	transmembrane transport
K06K5_27070	COG0191	fructose-bisphosphate aldolase activity
K06K5_27100	COG4771	TonB-dependent receptor
K06K5_27110	COG0583	DNA-binding transcription factor activity
K06K5_27120	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K06K5_27130	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K06K5_27150	COG3091	SprT-like family
K06K5_27160	COG2356	endonuclease I
K06K5_27170	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K06K5_27180	COG0189	ligase activity
K06K5_27190	COG1678	Uncharacterized ACR, COG1678
K06K5_27200	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K06K5_27230	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K06K5_27240	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K06K5_27250	COG0762	integral membrane protein
K06K5_27260	COG1872	DUF167
K06K5_27280	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K06K5_27290	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K06K5_27300	COG2066	Belongs to the glutaminase family
K06K5_27320	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K06K5_27340	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
K06K5_27430	COG0840	transmembrane signaling receptor activity
K06K5_27580	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K06K5_27600	COG3394	polysaccharide catabolic process
K06K5_27610	COG1486	melibiose metabolic process
K06K5_27620	COG1447	Phosphotransferase system cellobiose-specific component IIA
K06K5_27630	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K06K5_27650	COG0726	polysaccharide deacetylase
K06K5_27670	COG1028	Short-chain dehydrogenase reductase Sdr
K06K5_27680	COG4325	translation initiation factor activity
K06K5_27700	COG0795	lipopolysaccharide-transporting ATPase activity
K06K5_27710	COG0795	lipopolysaccharide-transporting ATPase activity
K06K5_27720	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K06K5_27730	COG2927	DNA polymerase III (CHI subunit)
K06K5_27740	COG0525	valine-tRNA ligase activity
K06K5_27760	COG0456	acetyltransferase
K06K5_27820	COG0540	Belongs to the ATCase OTCase family
K06K5_27830	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K06K5_27840	COG0251	oxidation-reduction process
K06K5_27850	COG0204	Acyl-transferase
K06K5_27860	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K06K5_27870	COG5007	Belongs to the BolA IbaG family
K06K5_27890	COG2854	intermembrane phospholipid transfer
K06K5_27900	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K06K5_27910	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K06K5_27920	COG1127	ABC transporter
K06K5_27940	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K06K5_27940	COG0517	IMP dehydrogenase activity
K06K5_27960	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K06K5_27970	COG1137	ATPase activity
K06K5_27990	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K06K5_28000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K06K5_28010	COG1660	Displays ATPase and GTPase activities
K06K5_28020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K06K5_28030	COG2239	Acts as a magnesium transporter
K06K5_28040	COG0312	modulator of DNA gyrase
K06K5_28050	COG3028	Belongs to the UPF0307 family
K06K5_28060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K06K5_28070	COG0564	pseudouridine synthase activity
K06K5_28090	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K06K5_28100	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K06K5_28110	COG0312	modulator of DNA gyrase
K06K5_28120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K06K5_28130	COG3164	Protein of unknown function
K06K5_28140	COG1530	ribonuclease E activity
K06K5_28150	COG0424	maF-like protein
K06K5_28160	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K06K5_28170	COG1792	Involved in formation and maintenance of cell shape
K06K5_28180	COG1077	Cell shape determining protein MreB Mrl
K06K5_28270	COG1459	type II secretion system
K06K5_28280	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K06K5_28300	COG3267	Type II secretory pathway component ExeA
K06K5_28300	COG3409	Peptidoglycan-binding domain 1 protein
K06K5_28310	COG1450	Type ii and iii secretion system protein
K06K5_28350	COG2199	diguanylate cyclase activity
K06K5_28350	COG2200	EAL domain
K06K5_28360	COG0629	single-stranded DNA binding
K06K5_28390	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K06K5_28430	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K06K5_28440	COG0527	aspartate kinase activity
K06K5_28450	COG0646	methionine synthase
K06K5_28450	COG1410	methionine synthase
K06K5_28580	COG0175	sulfate reduction
K06K5_28590	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K06K5_28600	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K06K5_28640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K06K5_28650	COG0735	belongs to the Fur family
K06K5_28670	COG0166	Belongs to the GPI family
K06K5_28680	COG0432	Pfam Uncharacterised protein family UPF0047
K06K5_28690	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K06K5_28700	COG0305	Participates in initiation and elongation during chromosome replication
K06K5_28740	COG2965	DNA replication, synthesis of RNA primer
K06K5_28750	COG0360	Binds together with S18 to 16S ribosomal RNA
K06K5_28760	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K06K5_28770	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K06K5_28790	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K06K5_28800	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K06K5_28860	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K06K5_28880	COG0678	peroxiredoxin activity
K06K5_28880	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K06K5_28890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K06K5_28920	COG0165	Argininosuccinate lyase
K06K5_28920	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K06K5_28930	COG0137	argininosuccinate synthase activity
K06K5_28950	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K06K5_28970	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K06K5_28990	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K06K5_29000	COG0527	aspartate kinase activity
K06K5_29000	COG0460	homoserine dehydrogenase
K06K5_29010	COG0626	cystathionine gamma-synthase activity
K06K5_29030	COG0281	malic enzyme
K06K5_29050	COG2906	2 iron, 2 sulfur cluster binding
K06K5_29060	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K06K5_29070	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K06K5_29110	COG2923	Belongs to the DsrF TusC family
K06K5_29120	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
K06K5_29130	COG2964	Protein conserved in bacteria
K06K5_29140	COG0545	Peptidyl-prolyl cis-trans isomerase
K06K5_29170	COG1446	asparaginase
K06K5_29180	COG1047	Peptidyl-prolyl cis-trans
K06K5_29210	COG2249	NAD(P)H dehydrogenase (quinone) activity
K06K5_29220	COG0488	(ABC) transporter
K06K5_29240	COG0429	hydrolase of the alpha beta-hydrolase fold
K06K5_29260	COG3954	Phosphoribulokinase
K06K5_29270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K06K5_29310	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K06K5_29320	COG0512	Glutamine amidotransferase of anthranilate synthase
K06K5_29350	COG0180	Tryptophanyl-tRNA synthetase
K06K5_29360	COG0546	phosphoglycolate phosphatase activity
K06K5_29370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K06K5_29380	COG0557	exoribonuclease II activity
K06K5_29390	COG1959	2 iron, 2 sulfur cluster binding
K06K5_29400	COG1017	nitric oxide dioxygenase activity
K06K5_29400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K06K5_29410	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
K06K5_29420	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K06K5_29430	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
K06K5_29440	COG0330	HflC and HflK could
K06K5_29450	COG0330	HflC and HflK could
K06K5_29460	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K06K5_29480	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K06K5_29490	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K06K5_29510	COG0802	atpase or kinase
K06K5_29530	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K06K5_29660	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K06K5_29670	COG1162	GTPase activity
K06K5_29680	COG0688	phosphatidylethanolamine metabolic process
K06K5_29690	COG0471	metal ion transport
K06K5_29710	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K06K5_29720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K06K5_29730	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K06K5_29740	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K06K5_29750	COG1045	serine acetyltransferase
K06K5_29760	COG4942	peptidase
K06K5_29800	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K06K5_29810	COG1053	succinate dehydrogenase
K06K5_29820	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K06K5_29830	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K06K5_29840	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K06K5_29870	COG1509	lysine 2,3-aminomutase activity
K06K5_29880	COG1285	pathogenesis
K06K5_29900	COG0459	protein refolding
K06K5_29910	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K06K5_29920	COG0534	Mate efflux family protein
K06K5_29930	COG0205	6-phosphofructokinase activity
K06K5_29940	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K06K5_29950	COG3678	ATP-independent chaperone mediated protein folding
K06K5_29960	COG0745	RESPONSE REGULATOR receiver
K06K5_29970	COG2205	protein histidine kinase activity
K06K5_29990	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K06K5_30000	COG3030	protein affecting phage T7 exclusion by the F plasmid
K06K5_30010	COG1027	Aspartate ammonia-lyase
K06K5_30020	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K06K5_30030	COG4232	protein-disulfide reductase activity
K06K5_30050	COG3263	regulation of cellular component size
K06K5_30070	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K06K5_30120	COG2814	Major facilitator Superfamily
K06K5_30150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K06K5_30160	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K06K5_30170	COG0511	ligase activity, forming carbon-carbon bonds
K06K5_30180	COG0439	Biotin carboxylase
K06K5_30190	COG2264	protein methyltransferase activity
K06K5_30200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K06K5_30210	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K06K5_30230	COG0488	(ABC) transporter
K06K5_30330	COG1982	Orn Lys Arg decarboxylase major
K06K5_30340	COG0531	amino acid
K06K5_30350	COG3710	Transcriptional regulator
K06K5_30360	COG0789	Transcriptional regulator
K06K5_30380	COG0151	Belongs to the GarS family
K06K5_30410	COG1253	flavin adenine dinucleotide binding
K06K5_30420	COG3068	Protein conserved in bacteria
K06K5_30440	COG1573	uracil-dna glycosylase
K06K5_30450	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K06K5_30460	COG2816	NAD+ diphosphatase activity
K06K5_30470	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
K06K5_30480	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K06K5_30490	COG0085	RNA polymerase activity
K06K5_30500	COG0222	ribosome binding
K06K5_30510	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K06K5_30540	COG0250	Participates in transcription elongation, termination and antitermination
K06K5_30550	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K06K5_30560	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K06K5_30620	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K06K5_30620	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K06K5_30630	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K06K5_30650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K06K5_30820	COG4206	TonB-dependent receptor
K06K5_30860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K06K5_30870	COG0534	Mate efflux family protein
K06K5_30880	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K06K5_30890	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K06K5_30900	COG2937	Belongs to the GPAT DAPAT family
K06K5_30910	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K06K5_30920	COG3161	chorismate lyase activity
K06K5_30930	COG1580	Controls the rotational direction of flagella during chemotaxis
K06K5_30940	COG0705	Rhomboid family
K06K5_30950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K06K5_30970	COG2177	Part of the ABC transporter FtsEX involved in
K06K5_30980	COG2884	Cell division ATP-binding protein ftsE
K06K5_30990	COG0552	protein localization to endoplasmic reticulum
K06K5_31000	COG0742	ribosomal rna small subunit methyltransferase
K06K5_31020	COG2095	MarC family integral membrane protein
K06K5_31100	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K06K5_31110	COG0640	Transcriptional regulator
K06K5_31120	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K06K5_31130	COG1280	lysine exporter protein (LysE YggA)
K06K5_31140	COG2267	carboxylic ester hydrolase activity
K06K5_31150	COG0561	phosphatase activity
K06K5_31190	COG3287	FIST C domain
K06K5_31190	COG2199	diguanylate cyclase activity
K06K5_31190	COG2200	EAL domain
K06K5_31200	COG1011	Hydrolase
K06K5_31210	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K06K5_31240	COG0019	diaminopimelate decarboxylase activity
K06K5_31250	COG1965	Belongs to the frataxin family
K06K5_31260	COG3072	Adenylate cyclase
K06K5_31270	COG0181	hydroxymethylbilane synthase activity
K06K5_31280	COG1587	Uroporphyrinogen-III synthase
K06K5_31290	COG2959	enzyme of heme biosynthesis
K06K5_31300	COG3071	HemY protein
K06K5_31390	COG0633	Ferredoxin
K06K5_31400	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K06K5_31420	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K06K5_31430	COG3118	belongs to the thioredoxin family
K06K5_31440	COG0513	Belongs to the DEAD box helicase family
K06K5_31450	COG0248	Ppx GppA phosphatase
K06K5_31470	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K06K5_31490	COG0514	ATP-dependent DNA helicase (RecQ)
K06K5_31500	COG2962	Rard protein
K06K5_31520	COG1280	lysine exporter protein (LysE YggA)
K06K5_31530	COG0405	Gamma-glutamyltransferase
K06K5_31540	COG0210	DNA helicase
K06K5_31560	COG3220	belongs to the UPF0276 family
K06K5_31620	COG0006	proline dipeptidase activity
K06K5_31620	COG0006	proline dipeptidase activity
K06K5_31650	COG2104	thiamine diphosphate biosynthetic process
K06K5_31660	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K06K5_31700	COG2132	Multicopper oxidase
K06K5_31800	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K06K5_31840	COG0009	L-threonylcarbamoyladenylate synthase
K06K5_31850	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K06K5_31860	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K06K5_31870	COG0551	DNA topoisomerase type I activity
K06K5_31880	COG2922	Belongs to the Smg family
K06K5_31890	COG0758	DNA mediated transformation
K06K5_31910	COG0242	peptide deformylase activity
K06K5_31920	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K06K5_31930	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K06K5_31930	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K06K5_31940	COG0569	domain protein
K06K5_31950	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K06K5_31970	COG1272	protein, Hemolysin III
K06K5_31980	COG4326	sporulation control protein
K06K5_32000	COG3084	Protein conserved in bacteria
K06K5_32020	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K06K5_32030	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K06K5_32040	COG0204	Acyl-transferase
K06K5_32060	COG0606	chelatase, subunit chli
K06K5_32080	COG3978	acetolactate synthase activity
K06K5_32090	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K06K5_32100	COG0129	dihydroxy-acid dehydratase activity
K06K5_32120	COG0583	DNA-binding transcription factor activity
K06K5_32130	COG2814	Major facilitator Superfamily
K06K5_32150	COG0765	amino acid transport
K06K5_32180	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K06K5_32190	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K06K5_32200	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K06K5_32210	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K06K5_32220	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K06K5_32230	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K06K5_32250	COG0356	it plays a direct role in the translocation of protons across the membrane
K06K5_32260	COG3312	ion transport
K06K5_32270	COG1475	DNA binding
K06K5_32280	COG1192	Involved in chromosome partitioning
K06K5_32290	COG0357	Ribosomal RNA small subunit methyltransferase G
K06K5_32300	COG0445	tRNA wobble uridine modification
K06K5_32310	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K06K5_32330	COG0706	membrane insertase activity
K06K5_32340	COG0594	ribonuclease P activity
K06K5_32360	COG1126	abc transporter atp-binding protein
K06K5_32410	COG1444	tRNA N-acetyltransferase activity
K06K5_32450	COG3340	Belongs to the peptidase S51 family
K06K5_32460	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K06K5_32470	COG1263	PTS System
K06K5_32470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K06K5_32480	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K06K5_32510	COG4166	transmembrane transport
K06K5_32610	COG0259	pyridoxamine-phosphate oxidase activity
K06K5_32660	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K06K5_32740	COG1132	(ABC) transporter
K06K5_32760	COG0513	Belongs to the DEAD box helicase family
K06K5_32770	COG2258	MOSC domain
K06K5_32860	COG3634	alkyl hydroperoxide reductase activity
K06K5_32870	COG0450	alkyl hydroperoxide reductase
K06K5_32950	COG1846	Transcriptional regulator
K06K5_32960	COG1764	response to oxidative stress
K06K5_33040	COG1136	(ABC) transporter
K06K5_33090	COG0745	RESPONSE REGULATOR receiver
K06K5_33110	COG1653	transport
K06K5_33120	COG0019	diaminopimelate decarboxylase activity
K06K5_33130	COG4264	IucA IucC family
K06K5_33180	COG4772	TonB-dependent receptor
K06K5_33190	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K06K5_33200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K06K5_33210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K06K5_33220	COG1120	ATPase activity
K06K5_33230	COG0840	transmembrane signaling receptor activity
K06K5_33240	COG0612	Peptidase, M16
K06K5_33260	COG0739	heme binding
K06K5_33290	COG2814	Major facilitator Superfamily
K06K5_33310	COG1609	Transcriptional regulator
K06K5_33320	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K06K5_33370	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K06K5_33380	COG1609	Transcriptional regulator
K06K5_33430	COG0596	Alpha beta hydrolase
K06K5_33480	COG1760	l-serine dehydratase
K06K5_33500	COG4580	involved in the transport of maltose and maltodextrins
K06K5_33540	COG2356	endonuclease I
K06K5_33580	COG1982	Orn Lys Arg decarboxylase major
K06K5_33590	COG0531	amino acid
K06K5_33610	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K06K5_33620	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
K06K5_33630	COG1162	GTPase activity
K06K5_33640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K06K5_33640	COG1263	PTS System
K06K5_33650	COG1999	signal sequence binding
K06K5_33680	COG2909	trisaccharide binding
K06K5_33690	COG0058	SHG alpha-glucan phosphorylase activity
K06K5_33700	COG1640	4-alpha-glucanotransferase
K06K5_33710	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K06K5_33720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K06K5_33730	COG0366	Alpha amylase catalytic
K06K5_33750	COG3366	ferrous iron transmembrane transporter activity
K06K5_33760	COG0700	Nucleoside recognition
K06K5_33770	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K06K5_33780	COG3339	Conserved Protein
K06K5_33790	COG1301	dicarboxylic acid transport
K06K5_33810	COG0583	DNA-binding transcription factor activity
K06K5_33860	COG1596	polysaccharide export
K06K5_33890	COG2095	MarC family integral membrane protein
K06K5_33900	COG4667	esterase of the alpha-beta hydrolase superfamily
K06K5_33910	COG3397	chitin binding
K06K5_33920	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K06K5_33930	COG0415	Belongs to the DNA photolyase family
K06K5_33970	COG1686	Belongs to the peptidase S11 family
K06K5_34020	COG0583	DNA-binding transcription factor activity
K06K5_34030	COG4628	conserved protein (DUF2132)
K06K5_34080	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K06K5_34090	COG0628	permease
K06K5_34140	COG1289	transmembrane transporter activity
K06K5_34170	COG2814	Major facilitator Superfamily
K06K5_34190	COG0454	-acetyltransferase
K06K5_34210	COG0745	RESPONSE REGULATOR receiver
K06K5_34220	COG2205	protein histidine kinase activity
K06K5_34250	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K06K5_34260	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K06K5_34340	COG1360	Flagellar Motor Protein
K06K5_34350	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K06K5_34360	COG1191	sigma factor activity
K06K5_34370	COG1580	Controls the rotational direction of flagella during chemotaxis
K06K5_34400	COG1516	flagellar protein fliS
K06K5_34410	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K06K5_34430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K06K5_34460	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K06K5_34480	COG1987	bacterial-type flagellum assembly
K06K5_34530	COG2204	response regulator
K06K5_34560	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K06K5_34670	COG0346	lactoylglutathione lyase activity
K06K5_34720	COG0745	RESPONSE REGULATOR receiver
K06K5_34770	COG5001	Diguanylate cyclase
K06K5_34770	COG3300	MHYT domain
K06K5_34780	COG0156	8-amino-7-oxononanoate synthase activity
K06K5_34790	COG1063	alcohol dehydrogenase
K06K5_34860	COG0668	transmembrane transport
K06K5_34880	COG1304	FMN binding
K06K5_34890	COG1620	l-lactate permease
K06K5_34900	COG0583	DNA-binding transcription factor activity
K06K5_34910	COG1505	serine-type exopeptidase activity
K06K5_34920	COG4172	Belongs to the ABC transporter superfamily
K06K5_34940	COG1067	ATP-dependent peptidase activity
K06K5_34960	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K06K5_35000	COG1247	-acetyltransferase
K06K5_35010	COG0437	4 iron, 4 sulfur cluster binding
K06K5_35020	COG0348	domain, Protein
K06K5_35060	COG1122	ATPase activity
K06K5_35070	COG4720	Psort location CytoplasmicMembrane, score
K06K5_35080	COG1566	PFAM secretion protein HlyD family protein
K06K5_35100	COG3706	GGDEF domain
K06K5_35130	COG0813	purine-nucleoside phosphorylase activity
K06K5_35140	COG3272	Protein of unknown function (DUF1722)
K06K5_35150	COG0789	Transcriptional regulator
K06K5_35160	COG0415	Belongs to the DNA photolyase family
K06K5_35170	COG1388	LysM domain
K06K5_35170	COG1376	ErfK ybiS ycfS ynhG family protein
K06K5_35190	COG0513	Belongs to the DEAD box helicase family
K06K5_35200	COG1770	oligopeptidase
K06K5_35210	COG4771	TonB-dependent receptor
K06K5_35260	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K06K5_35270	COG0573	inorganic phosphate transmembrane transporter activity
K06K5_35280	COG0581	inorganic phosphate transmembrane transporter activity
K06K5_35290	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K06K5_35320	COG2304	oxidoreductase activity
K06K5_35360	COG0714	Associated with various cellular activities
K06K5_35390	COG2197	response regulator
K06K5_35460	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K06K5_35470	COG1120	ATPase activity
K06K5_35480	COG4774	siderophore transport
K06K5_35490	COG1132	(ABC) transporter
K06K5_35520	COG0569	domain protein
K06K5_35530	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K06K5_35540	COG0583	DNA-binding transcription factor activity
K06K5_35580	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K06K5_35590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K06K5_35610	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
K06K5_35620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K06K5_35680	COG2084	Dehydrogenase
K06K5_35690	COG0753	catalase activity
K06K5_35710	COG2130	NADP-dependent
K06K5_35720	COG1309	transcriptional regulator
K06K5_35810	COG0489	protein tyrosine kinase activity
K06K5_35810	COG3206	protein involved in exopolysaccharide biosynthesis
K06K5_35840	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K06K5_35850	COG3842	ATPase activity
K06K5_35870	COG1175	transmembrane transport
K06K5_35880	COG3833	ABC-type maltose transport systems, permease component
K06K5_35940	COG2354	Protein conserved in bacteria
K06K5_35950	COG0418	dihydroorotase activity
K06K5_35960	COG0401	homolog of Blt101
K06K5_35970	COG0633	Ferredoxin
K06K5_35970	COG3217	Mosc domain protein beta barrel domain protein
K06K5_35970	COG0633	Ferredoxin
K06K5_35970	COG3217	Mosc domain protein beta barrel domain protein
K06K5_35990	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K06K5_36070	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K06K5_36080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K06K5_36100	COG0848	biopolymer transport protein
K06K5_36110	COG0811	peptide transport
K06K5_36120	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K06K5_36140	COG3721	Heme iron utilization protein
K06K5_36150	COG0748	coenzyme F420 binding
K06K5_36170	COG0835	chemotaxis
K06K5_36170	COG0784	Response regulator, receiver
K06K5_36180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K06K5_36190	COG0534	Mate efflux family protein
K06K5_36200	COG0444	Belongs to the ABC transporter superfamily
K06K5_36210	COG4608	Belongs to the ABC transporter superfamily
K06K5_36220	COG0747	negative chemotaxis
K06K5_36240	COG1349	DNA-binding transcription factor activity
K06K5_36250	COG2084	Dehydrogenase
K06K5_36260	COG3395	kinase activity
K06K5_36270	COG0235	Class ii aldolase
K06K5_36280	COG3622	Belongs to the hyi family
K06K5_36290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K06K5_36300	COG2610	gluconate transmembrane transporter activity
K06K5_36340	COG0583	DNA-binding transcription factor activity
K06K5_36350	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K06K5_36370	COG4934	collagen metabolic process
K06K5_36390	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K06K5_36400	COG0789	Transcriptional regulator
K06K5_36410	COG0366	Alpha amylase catalytic
K06K5_36450	COG2249	NAD(P)H dehydrogenase (quinone) activity
K06K5_36460	COG0589	response to stress
K06K5_36470	COG0488	(ABC) transporter
K06K5_36480	COG1505	serine-type exopeptidase activity
K06K5_36500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K06K5_36520	COG2067	long-chain fatty acid transport protein
K06K5_36540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K06K5_36590	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K06K5_36630	COG3383	formate dehydrogenase (NAD+) activity
K06K5_36650	COG0842	Transport permease protein
K06K5_36660	COG1131	(ABC) transporter
K06K5_36700	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
K06K5_36720	COG4145	pantothenate transmembrane transporter activity
K06K5_36730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K06K5_36740	COG0800	Aldolase
K06K5_36760	COG2706	6-phosphogluconolactonase activity
K06K5_36770	COG0251	oxidation-reduction process
K06K5_36790	COG1881	PFAM PEBP family protein
K06K5_36810	COG0798	PFAM Bile acid sodium symporter
K06K5_36840	COG1733	regulation of RNA biosynthetic process
K06K5_36900	COG4989	oxidoreductase activity
K06K5_36950	COG0814	amino acid
K06K5_37020	COG0739	heme binding
K06K5_37030	COG5001	Diguanylate cyclase
K06K5_37040	COG0583	DNA-binding transcription factor activity
K06K5_37050	COG2814	Major facilitator Superfamily
K06K5_37090	COG0697	spore germination
K06K5_37120	COG0179	Fumarylacetoacetate (FAA) hydrolase
K06K5_37160	COG1280	lysine exporter protein (LysE YggA)
K06K5_37180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K06K5_37190	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K06K5_37210	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K06K5_37220	COG1845	cytochrome c oxidase, subunit III
K06K5_37250	COG1612	heme a metabolic process
K06K5_37260	COG0109	protoheme IX farnesyltransferase activity
K06K5_37270	COG0545	Peptidyl-prolyl cis-trans isomerase
K06K5_37330	COG1278	Cold shock
K06K5_37340	COG3036	rescue of stalled ribosome
K06K5_37350	COG2199	diguanylate cyclase activity
K06K5_37380	COG1132	(ABC) transporter
K06K5_37390	COG1132	(ABC) transporter
K06K5_37400	COG1538	Outer membrane efflux protein
K06K5_37410	COG2205	protein histidine kinase activity
K06K5_37410	COG0784	Response regulator, receiver
K06K5_37460	COG0840	transmembrane signaling receptor activity
K06K5_37480	COG0783	Belongs to the Dps family
K06K5_37500	COG2133	pyrroloquinoline quinone binding
K06K5_37510	COG1454	alcohol dehydrogenase
K06K5_37520	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
K06K5_37570	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K06K5_37580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K06K5_37590	COG3186	Phenylalanine-4-hydroxylase
K06K5_37640	COG3530	Putative quorum-sensing-regulated virulence factor
K06K5_37680	COG0513	Belongs to the DEAD box helicase family
K06K5_37690	COG4628	conserved protein (DUF2132)
K06K5_37710	COG0133	tryptophan synthase activity
K06K5_37720	COG1278	Cold shock
K06K5_37740	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
K06K5_37760	COG0523	cobalamin synthesis protein
K06K5_37770	COG0513	Belongs to the DEAD box helicase family
K06K5_37810	COG2200	EAL domain
K06K5_37820	COG1119	ATPase activity
K06K5_37860	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K06K5_37890	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
K06K5_37900	COG0513	Belongs to the DEAD box helicase family
K06K5_37910	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K06K5_37930	COG1073	alpha beta
K06K5_37940	COG1073	alpha beta
K06K5_37970	COG0730	response to heat
K06K5_38000	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K06K5_38020	COG0523	cobalamin synthesis protein
K06K5_38030	COG2988	succinylglutamate desuccinylase activity
K06K5_38040	COG0739	heme binding
K06K5_38060	COG0523	cobalamin synthesis protein
K06K5_38080	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K06K5_38090	COG2095	MarC family integral membrane protein
K06K5_38140	COG1024	Enoyl-CoA hydratase
K06K5_38150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K06K5_38160	COG1960	acyl-CoA dehydrogenase activity
K06K5_38180	COG0183	Belongs to the thiolase family
K06K5_38210	COG1024	Enoyl-CoA hydratase
K06K5_38220	COG1024	Enoyl-CoA hydratase
K06K5_38240	COG1028	Short-chain dehydrogenase reductase Sdr
K06K5_38250	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K06K5_38260	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K06K5_38270	COG1845	cytochrome c oxidase, subunit III
K06K5_38280	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K06K5_38290	COG0109	protoheme IX farnesyltransferase activity
K06K5_38300	COG1902	pentaerythritol trinitrate reductase activity
K06K5_38300	COG0446	pyridine nucleotide-disulphide oxidoreductase
K06K5_38330	COG1012	belongs to the aldehyde dehydrogenase family
K06K5_38350	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K06K5_38410	COG1126	abc transporter atp-binding protein
K06K5_38420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K06K5_38430	COG4215	(ABC) transporter
K06K5_38440	COG4160	amino acid transport
K06K5_38580	COG0443	Heat shock 70 kDa protein
K06K5_38590	COG2847	Copper chaperone PCu(A)C
K06K5_38700	COG3706	GGDEF domain
K06K5_38720	COG0814	amino acid
K06K5_38740	COG0243	molybdopterin cofactor binding
K06K5_38780	COG3707	response regulator
K06K5_38790	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K06K5_38790	COG1116	anion transmembrane transporter activity
K06K5_38800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K06K5_38810	COG1116	anion transmembrane transporter activity
K06K5_38820	COG2146	nitrite reductase [NAD(P)H] activity
K06K5_38820	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K06K5_38920	COG2815	serine threonine protein kinase
K06K5_38920	COG0515	serine threonine protein kinase
K06K5_38990	COG0631	protein serine/threonine phosphatase activity
K06K5_39100	COG3501	Rhs element vgr protein
K06K5_39130	COG0420	3'-5' exonuclease activity
K06K5_39140	COG0419	ATPase involved in DNA repair
K06K5_39160	COG3040	lipid binding
K06K5_39180	COG1288	antiporter activity
K06K5_39200	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
K06K5_39230	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K06K5_39260	COG0583	DNA-binding transcription factor activity
K06K5_39270	COG0277	FAD linked oxidase domain protein
K06K5_39300	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K06K5_39370	COG2176	DNA-directed DNA polymerase activity
K06K5_39460	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
K06K5_39470	COG1328	CTP reductase activity
K06K5_39920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K06K5_39960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K06K5_39980	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K06K5_39990	COG2146	nitrite reductase [NAD(P)H] activity
K06K5_40000	COG2116	formate transmembrane transporter activity
K06K5_40040	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K06K5_40100	COG2814	Major facilitator Superfamily
K06K5_40110	COG3118	belongs to the thioredoxin family
K06K5_40120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K06K5_40170	COG2271	Major facilitator Superfamily
K06K5_40180	COG3851	Histidine kinase
K06K5_40190	COG2197	response regulator
K06K5_40210	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K06K5_40220	COG0583	DNA-binding transcription factor activity
K06K5_40230	COG0243	molybdopterin cofactor binding
K06K5_40260	COG0384	phenazine biosynthesis protein PhzF
K06K5_40270	COG1794	racemase activity, acting on amino acids and derivatives
K06K5_40330	COG1328	CTP reductase activity
K06K5_40340	COG0602	queuosine metabolic process
K06K5_40350	COG0534	Mate efflux family protein
K06K5_40360	COG2207	Transcriptional regulator
K06K5_40380	COG0189	ligase activity
K06K5_40380	COG4067	protein conserved in archaea
K06K5_40400	COG3111	PFAM Bacterial OB fold (BOF) protein
K06K5_40420	COG0725	ABC transporter, periplasmic molybdate-binding protein
K06K5_40430	COG4149	molybdate abc transporter
K06K5_40440	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K06K5_40460	COG4251	negative regulation of phosphorylation
K06K5_40460	COG5001	Diguanylate cyclase
K06K5_40460	COG3706	GGDEF domain
K06K5_40460	COG2203	Gaf domain
K06K5_40470	COG0745	RESPONSE REGULATOR receiver
K06K5_40470	COG3706	GGDEF domain
K06K5_40500	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K06K5_40510	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K06K5_40560	COG3140	Belongs to the UPF0181 family
K06K5_40590	COG0583	DNA-binding transcription factor activity
K06K5_40890	COG0023	Translation Initiation Factor
K06K5_40910	COG1181	Belongs to the D-alanine--D-alanine ligase family
K06K5_40930	COG1042	CoA-binding domain protein
K06K5_40930	COG0045	succinate-CoA ligase (ADP-forming) activity
K06K5_40930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K06K5_40940	COG0583	DNA-binding transcription factor activity
K06K5_40970	COG5002	protein histidine kinase activity
K06K5_40970	COG5001	Diguanylate cyclase
K06K5_40970	COG3447	MASE1 domain protein
K06K5_40980	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K06K5_40990	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K06K5_41000	COG1984	allophanate hydrolase subunit 2
K06K5_41020	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K06K5_41030	COG4181	ATPase activity
K06K5_41050	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K06K5_41060	COG3300	MHYT domain
K06K5_41060	COG5001	Diguanylate cyclase
K06K5_41130	COG4533	DNA binding
K06K5_41150	COG2050	protein possibly involved in aromatic compounds catabolism
K06K5_41180	COG2067	long-chain fatty acid transport protein
K06K5_41190	COG2267	carboxylic ester hydrolase activity
K06K5_41230	COG0861	Integral membrane protein TerC family
K06K5_41240	COG0737	Belongs to the 5'-nucleotidase family
K06K5_41250	COG3593	DNA synthesis involved in DNA repair
K06K5_41270	COG0583	DNA-binding transcription factor activity
K06K5_41290	COG2116	formate transmembrane transporter activity
K06K5_41300	COG2353	YceI-like domain
K06K5_41310	COG3038	cytochrome b561
K06K5_41350	COG0513	Belongs to the DEAD box helicase family
K06K5_41360	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
K06K5_41380	COG0840	transmembrane signaling receptor activity
K06K5_41390	COG0546	phosphoglycolate phosphatase activity
K06K5_41420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K06K5_41430	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K06K5_41440	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K06K5_41460	COG2207	Transcriptional regulator
K06K5_41470	COG1979	alcohol dehydrogenase
K06K5_41490	COG1126	abc transporter atp-binding protein
K06K5_41500	COG0765	amino acid transport
K06K5_41510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K06K5_41520	COG0765	amino acid transport
K06K5_41530	COG2199	diguanylate cyclase activity
K06K5_41530	COG2203	Gaf domain
K06K5_41530	COG2200	EAL domain
K06K5_41560	COG1609	Transcriptional regulator
K06K5_41570	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K06K5_41570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K06K5_41580	COG1105	Belongs to the carbohydrate kinase PfkB family
K06K5_41590	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
K06K5_41590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K06K5_41590	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K06K5_41650	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K06K5_41670	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K06K5_41680	COG0509	glycine decarboxylation via glycine cleavage system
K06K5_41700	COG0346	lactoylglutathione lyase activity
K06K5_41710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K06K5_41720	COG0583	DNA-binding transcription factor activity
K06K5_41730	COG0697	spore germination
K06K5_41740	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K06K5_41800	COG2176	DNA-directed DNA polymerase activity
K06K5_41880	COG0242	peptide deformylase activity
K06K5_41940	COG2239	Acts as a magnesium transporter
K06K5_41980	COG0346	lactoylglutathione lyase activity
K06K5_41990	COG1902	pentaerythritol trinitrate reductase activity
K06K5_42010	COG2755	lipolytic protein G-D-S-L family
K06K5_42010	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K06K5_42040	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K06K5_42050	COG0069	glutamate synthase activity
K06K5_42050	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K06K5_42110	COG2076	Multidrug Resistance protein
K06K5_42150	COG2962	Rard protein
K06K5_42180	COG0835	chemotaxis
K06K5_42180	COG0784	Response regulator, receiver
K06K5_42190	COG2197	response regulator
K06K5_42210	COG3706	GGDEF domain
K06K5_42220	COG2197	response regulator
K06K5_42230	COG5001	Diguanylate cyclase
K06K5_42230	COG3300	MHYT domain
K06K5_42240	COG0784	Response regulator, receiver
K06K5_42240	COG2205	protein histidine kinase activity
K06K5_42250	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K06K5_42290	COG1214	PFAM Peptidase M22, glycoprotease
K06K5_42290	COG0456	acetyltransferase
K06K5_42310	COG3069	C4-dicarboxylate transmembrane transporter activity
K06K5_42360	COG3111	PFAM Bacterial OB fold (BOF) protein
K06K5_42370	COG1597	lipid kinase activity
K06K5_42380	COG0583	DNA-binding transcription factor activity
K06K5_42390	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K06K5_42450	COG0714	Associated with various cellular activities
K06K5_42460	COG0641	radical SAM
K06K5_42470	COG3119	arylsulfatase activity
K06K5_42490	COG3119	arylsulfatase activity
K06K5_42500	COG0745	RESPONSE REGULATOR receiver
K06K5_42530	COG0784	Response regulator, receiver
K06K5_42530	COG2205	protein histidine kinase activity
K06K5_42530	COG2198	Histidine kinase
K06K5_42540	COG1879	ABC-type sugar transport system periplasmic component
K06K5_42550	COG1803	Methylglyoxal synthase
K06K5_42560	COG0210	DNA helicase
K06K5_42570	COG1289	transmembrane transporter activity
K06K5_42720	COG2198	Histidine kinase
K06K5_42720	COG2205	protein histidine kinase activity
K06K5_42720	COG0784	Response regulator, receiver
K06K5_42730	COG1879	ABC-type sugar transport system periplasmic component
K06K5_42740	COG1803	Methylglyoxal synthase
K06K5_42750	COG0210	DNA helicase
K06K5_42760	COG1289	transmembrane transporter activity
K06K5_42820	COG1629	transport
K06K5_42820	COG4771	TonB-dependent receptor
K06K5_42840	COG0789	Transcriptional regulator
K06K5_42850	COG4604	ABC transporter, ATP-binding protein
K06K5_42860	COG4605	iron ion homeostasis
K06K5_42870	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K06K5_42880	COG4607	ABC-type enterochelin transport system periplasmic component
K06K5_42900	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
K06K5_42930	COG1609	Transcriptional regulator
K06K5_42940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K06K5_42950	COG1879	ABC-type sugar transport system periplasmic component
K06K5_42960	COG1172	Belongs to the binding-protein-dependent transport system permease family
K06K5_42970	COG1129	ABC transporter
K06K5_42980	COG1869	D-ribose catabolic process
K06K5_42990	COG5001	Diguanylate cyclase
K06K5_43090	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K06K5_43110	COG2205	protein histidine kinase activity
K06K5_43110	COG0784	Response regulator, receiver
K06K5_43140	COG0330	HflC and HflK could
K06K5_43170	COG0517	IMP dehydrogenase activity
K06K5_43170	COG4175	Glycine betaine
K06K5_43180	COG4176	ABC-type proline glycine betaine transport system permease component
K06K5_43210	COG1012	belongs to the aldehyde dehydrogenase family
K06K5_43220	COG1309	transcriptional regulator
K06K5_43230	COG0745	RESPONSE REGULATOR receiver
K06K5_43230	COG3706	GGDEF domain
K06K5_43240	COG1028	Short-chain dehydrogenase reductase Sdr
K06K5_43270	COG1024	Enoyl-CoA hydratase
K06K5_43280	COG1960	acyl-CoA dehydrogenase activity
K06K5_43300	COG0183	Belongs to the thiolase family
K06K5_43320	COG1960	acyl-CoA dehydrogenase activity
K06K5_43330	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K06K5_43380	COG3264	Mechanosensitive ion channel
K06K5_43380	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K06K5_43390	COG0110	maltose O-acetyltransferase activity
K06K5_43400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K06K5_43410	COG1271	oxidase subunit
K06K5_43420	COG1294	oxidase, subunit
K06K5_43440	COG0384	phenazine biosynthesis protein PhzF
K06K5_43480	COG3527	Alpha-acetolactate decarboxylase
K06K5_43500	COG1028	Short-chain dehydrogenase reductase Sdr
K06K5_43510	COG0500	methyltransferase
K06K5_43570	COG1022	Amp-dependent synthetase and ligase
K06K5_43620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K06K5_43630	COG1263	PTS System
K06K5_43630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K06K5_43640	COG1486	melibiose metabolic process
K06K5_43650	COG2188	Transcriptional regulator
K06K5_43660	COG1320	monovalent cation:proton antiporter activity
K06K5_43670	COG2212	antiporter activity
K06K5_43700	COG1006	Multisubunit Na H antiporter MnhC subunit
K06K5_43710	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K06K5_43710	COG2111	Na H antiporter
K06K5_43730	COG0589	response to stress
K06K5_43740	COG4221	oxidoreductase activity
K06K5_43750	COG0583	DNA-binding transcription factor activity
K06K5_43770	COG2814	Major facilitator Superfamily
K06K5_43900	COG1522	sequence-specific DNA binding
K06K5_43970	COG0515	serine threonine protein kinase
K06K5_44020	COG3501	Rhs element vgr protein
K06K5_44050	COG2204	response regulator
K06K5_44100	COG0739	heme binding
K06K5_44130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K06K5_44230	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K06K5_44250	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K06K5_44250	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K06K5_44280	COG4989	oxidoreductase activity
K06K5_44310	COG0038	chloride channel
K06K5_44380	COG2897	thiosulfate sulfurtransferase activity
K06K5_44400	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K06K5_44410	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K06K5_44420	COG0840	transmembrane signaling receptor activity
K06K5_44430	COG2814	Major facilitator Superfamily
K06K5_44440	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K06K5_44460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K06K5_44480	COG0840	transmembrane signaling receptor activity
K06K5_44520	COG2195	Cleaves the N-terminal amino acid of tripeptides
K06K5_44550	COG2197	response regulator
K06K5_44560	COG3850	Histidine kinase
K06K5_44570	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K06K5_44590	COG0243	molybdopterin cofactor binding
K06K5_44610	COG3005	denitrification pathway
K06K5_44630	COG3243	poly(R)-hydroxyalkanoic acid synthase
K06K5_44650	COG0183	Belongs to the thiolase family
K06K5_44670	COG1280	lysine exporter protein (LysE YggA)
K06K5_44690	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K06K5_44700	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K06K5_44800	COG1846	Transcriptional regulator
K06K5_44810	COG0784	Response regulator, receiver
K06K5_44810	COG2205	protein histidine kinase activity
K06K5_44820	COG1879	ABC-type sugar transport system periplasmic component
K06K5_44830	COG2827	Endonuclease containing a URI domain
K06K5_44840	COG3132	Protein of unknown function, DUF480
K06K5_44880	COG0784	Response regulator, receiver
K06K5_44880	COG2205	protein histidine kinase activity
K06K5_44880	COG5002	protein histidine kinase activity
K06K5_44940	COG0583	DNA-binding transcription factor activity
K06K5_44960	COG0531	amino acid
K06K5_44990	COG2205	protein histidine kinase activity
K06K5_45000	COG0745	RESPONSE REGULATOR receiver
K06K5_45060	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K06K5_45070	COG2239	Acts as a magnesium transporter
K06K5_45080	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K06K5_45090	COG0402	S-adenosylhomocysteine deaminase activity
K06K5_45100	COG1418	mRNA catabolic process
K06K5_45120	COG2814	Major facilitator Superfamily
K06K5_45140	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K06K5_45180	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K06K5_45210	COG0745	RESPONSE REGULATOR receiver
K06K5_45220	COG2205	protein histidine kinase activity
K06K5_45240	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K06K5_45250	COG2194	sulfuric ester hydrolase activity
K06K5_45290	COG4667	esterase of the alpha-beta hydrolase superfamily
K06K5_45300	COG1741	Belongs to the pirin family
K06K5_45310	COG1278	Cold shock
K06K5_45340	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K06K5_45350	COG0678	peroxiredoxin activity
K06K5_45350	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K06K5_45370	COG1686	Belongs to the peptidase S11 family
K06K5_45390	COG0625	glutathione transferase activity
K06K5_45400	COG1621	beta-fructofuranosidase activity
K06K5_45410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K06K5_45420	COG1263	PTS System
K06K5_45420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K06K5_45460	COG1028	Short-chain dehydrogenase reductase Sdr
K06K5_45490	COG3746	phosphate-selective porin O and P
K06K5_45520	COG0300	oxidoreductase activity
K06K5_45530	COG0583	DNA-binding transcription factor activity
K06K5_45540	COG2207	Transcriptional regulator
K06K5_45540	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K06K5_45550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K06K5_45590	COG0513	Belongs to the DEAD box helicase family
K06K5_45610	COG0583	DNA-binding transcription factor activity
K06K5_45640	COG1902	pentaerythritol trinitrate reductase activity
K06K5_45650	COG1063	alcohol dehydrogenase
K06K5_45670	COG1028	Short-chain dehydrogenase reductase Sdr
K06K5_45690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K06K5_45700	COG0006	proline dipeptidase activity
K06K5_45710	COG3608	succinylglutamate desuccinylase aspartoacylase
K06K5_45720	COG1522	sequence-specific DNA binding
K06K5_45730	COG1012	belongs to the aldehyde dehydrogenase family
K06K5_45740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K06K5_45750	COG3122	Protein conserved in bacteria
K06K5_45780	COG0583	DNA-binding transcription factor activity
K06K5_45800	COG0252	asparaginase activity
K06K5_45810	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K06K5_45840	COG2197	response regulator
K06K5_45850	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K06K5_45860	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K06K5_45900	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K06K5_45960	COG3842	ATPase activity
K06K5_46000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K06K5_46060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K06K5_46070	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K06K5_46130	COG0583	DNA-binding transcription factor activity
K06K5_46150	COG4948	Mandelate Racemase Muconate Lactonizing
K06K5_46160	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K06K5_46210	COG1342	Belongs to the UPF0251 family
K06K5_46220	COG4176	ABC-type proline glycine betaine transport system permease component
K06K5_46230	COG4175	Glycine betaine
K06K5_46230	COG3448	diguanylate cyclase activity
K06K5_46240	COG3015	lipoprotein NlpE involved in copper resistance
K06K5_46250	COG3713	MltA-interacting MipA family protein
K06K5_46280	COG0583	DNA-binding transcription factor activity
K06K5_46330	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K06K5_46350	COG1335	isochorismatase
K06K5_46380	COG1349	DNA-binding transcription factor activity
K06K5_46400	COG2070	2-Nitropropane dioxygenase
K06K5_46410	COG0531	amino acid
K06K5_46420	COG4302	ethanolamine ammonia-lyase activity
K06K5_46430	COG4303	Ethanolamine ammonia lyase large subunit
K06K5_46450	COG1309	transcriptional regulator
K06K5_46490	COG1280	lysine exporter protein (LysE YggA)
K06K5_46510	COG0459	protein refolding
K06K5_46520	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K06K5_46530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K06K5_46560	COG1304	FMN binding
K06K5_46610	COG4786	Flagellar basal body rod
K06K5_46610	COG1256	bacterial-type flagellum assembly
K06K5_46630	COG1706	bacterial-type flagellum-dependent cell motility
K06K5_46640	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K06K5_46650	COG4786	Flagellar basal body rod
K06K5_46660	COG4787	bacterial-type flagellum-dependent cell motility
K06K5_46670	COG1749	Flagellar hook protein flgE
K06K5_46680	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K06K5_46690	COG1558	bacterial-type flagellum-dependent cell motility
K06K5_46700	COG1815	bacterial-type flagellum-dependent cell motility
K06K5_46740	COG0741	lytic transglycosylase activity
K06K5_46750	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K06K5_46790	COG1760	l-serine dehydratase
K06K5_46820	COG0583	DNA-binding transcription factor activity
K06K5_46840	COG2866	Carboxypeptidase
K06K5_46850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K06K5_46870	COG2990	Protein conserved in bacteria
K06K5_46920	COG3842	ATPase activity
K06K5_46940	COG1840	ABC-type Fe3 transport system, periplasmic component
K06K5_46980	COG1609	Transcriptional regulator
K06K5_47040	COG3240	lipase activity
K06K5_47050	COG1309	transcriptional regulator
K06K5_47080	COG1136	(ABC) transporter
K06K5_47080	COG0577	efflux transmembrane transporter activity
K06K5_47090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K06K5_47100	COG2067	long-chain fatty acid transport protein
K06K5_47110	COG3338	carbonate dehydratase activity
K06K5_47120	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K06K5_47150	COG1011	Hydrolase
K06K5_47220	COG0110	maltose O-acetyltransferase activity
K06K5_47230	COG1765	OsmC-like protein
K06K5_47240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K06K5_47240	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K06K5_47260	COG3046	protein related to deoxyribodipyrimidine photolyase
K06K5_47270	COG0415	Belongs to the DNA photolyase family
K06K5_47280	COG3706	GGDEF domain
K06K5_47310	COG3706	GGDEF domain
K06K5_47340	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K06K5_47370	COG3033	Beta-eliminating lyase
K06K5_47390	COG1271	oxidase subunit
K06K5_47400	COG1294	oxidase, subunit
K06K5_47430	COG3179	chitinase
K06K5_47440	COG0579	oxidoreductase
K06K5_47490	COG3706	GGDEF domain
K06K5_47550	COG0583	DNA-binding transcription factor activity
K06K5_47590	COG0189	ligase activity
K06K5_47600	COG4067	protein conserved in archaea
K06K5_47600	COG0189	ligase activity
K06K5_47620	COG1166	arginine decarboxylase activity
K06K5_47630	COG0010	Belongs to the arginase family
K06K5_47640	COG2814	Major facilitator Superfamily
K06K5_47650	COG1770	oligopeptidase
K06K5_47680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K06K5_47690	COG1121	(ABC) transporter
K06K5_47700	COG0803	Belongs to the bacterial solute-binding protein 9 family
K06K5_47780	COG0848	biopolymer transport protein
K06K5_47790	COG0811	peptide transport
K06K5_47800	COG0811	peptide transport
K06K5_47840	COG0745	RESPONSE REGULATOR receiver
K06K5_47850	COG0584	glycerophosphoryl diester phosphodiesterase
K06K5_47870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K06K5_48000	COG0312	modulator of DNA gyrase
K06K5_48010	COG0312	modulator of DNA gyrase
K06K5_48020	COG0351	phosphomethylpyrimidine kinase
K06K5_48030	COG1116	anion transmembrane transporter activity
K06K5_48040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K06K5_48050	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K06K5_48060	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K06K5_48100	COG0243	molybdopterin cofactor binding
K06K5_48110	COG3005	denitrification pathway
K06K5_48120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K06K5_48130	COG1028	Short-chain dehydrogenase reductase Sdr
K06K5_48160	COG0456	acetyltransferase
K06K5_48200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K06K5_48210	COG1929	Belongs to the glycerate kinase type-1 family
K06K5_48220	COG2610	gluconate transmembrane transporter activity
K06K5_48230	COG3835	regulator
K06K5_48360	COG3047	cAMP biosynthetic process
K06K5_48380	COG1357	PFAM Pentapeptide repeats (8 copies)
K06K5_48440	COG2375	cellular response to nickel ion
K06K5_48450	COG0583	DNA-binding transcription factor activity
K06K5_48460	COG2162	N-hydroxyarylamine O-acetyltransferase activity
K06K5_48470	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K06K5_48520	COG2199	diguanylate cyclase activity
K06K5_48540	COG0561	phosphatase activity
K06K5_48550	COG0583	DNA-binding transcription factor activity
K06K5_48580	COG0564	pseudouridine synthase activity
K06K5_48590	COG0534	Mate efflux family protein
K06K5_48600	COG5001	Diguanylate cyclase
K06K5_48620	COG3123	guanosine phosphorylase activity
K06K5_48650	COG0596	Alpha beta hydrolase
K06K5_48710	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K06K5_48730	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K06K5_48740	COG2169	Transcriptional regulator
K06K5_48740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K06K5_48760	COG2259	Doxx family
K06K5_48770	COG1741	Belongs to the pirin family
K06K5_48810	COG0363	glucosamine-6-phosphate deaminase activity
K06K5_48830	COG0786	glutamate:sodium symporter activity
K06K5_48840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K06K5_48850	COG1131	(ABC) transporter
K06K5_48870	COG0786	glutamate:sodium symporter activity
K06K5_48910	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K06K5_48930	COG3279	Response regulator of the LytR AlgR family
K06K5_48940	COG3275	phosphorelay sensor kinase activity
K06K5_49000	COG0772	Belongs to the SEDS family
K06K5_49050	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K06K5_49050	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
K06K5_49070	COG0444	Belongs to the ABC transporter superfamily
K06K5_49080	COG4608	Belongs to the ABC transporter superfamily
K06K5_50030	COG0358	DNA primase activity
K06K5_50370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K06K5_51010	COG2916	Histone family protein nucleoid-structuring protein H-NS
K06K5_51560	COG0330	HflC and HflK could
K06K5_51570	COG0330	HflC and HflK could
K06K5_51680	COG5001	Diguanylate cyclase
K06K5_51680	COG4251	negative regulation of phosphorylation
K06K5_51680	COG3706	GGDEF domain
K06K5_51680	COG2203	Gaf domain
K06K5_51900	COG0358	DNA primase activity
K06K5_52510	COG0582	viral genome integration into host DNA
K06K5_52520	COG0582	viral genome integration into host DNA
K06K5_52550	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K06K5_52550	COG0519	Catalyzes the synthesis of GMP from XMP
K06K5_52700	COG2976	Protein conserved in bacteria