locus-tag	class	description
K08M3_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K08M3_00020	COG0592	DNA-directed DNA polymerase activity
K08M3_00040	COG0187	DNA topoisomerase II activity
K08M3_00070	COG0071	Belongs to the small heat shock protein (HSP20) family
K08M3_00080	COG3977	Valine--pyruvate aminotransferase
K08M3_00090	COG0366	Alpha amylase catalytic
K08M3_00120	COG2119	membrane
K08M3_00140	COG0425	Belongs to the sulfur carrier protein TusA family
K08M3_00170	COG0604	alcohol dehydrogenase
K08M3_00180	COG0183	Belongs to the thiolase family
K08M3_00200	COG1739	Uncharacterized protein family UPF0029
K08M3_00210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K08M3_00290	COG0583	DNA-binding transcription factor activity
K08M3_00300	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K08M3_00310	COG2960	long-chain fatty acid transporting porin activity
K08M3_00320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K08M3_00330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K08M3_00430	COG4172	Belongs to the ABC transporter superfamily
K08M3_00440	COG4166	transmembrane transport
K08M3_00460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K08M3_00480	COG1609	Transcriptional regulator
K08M3_00490	COG0583	DNA-binding transcription factor activity
K08M3_00510	COG2076	Multidrug Resistance protein
K08M3_00520	COG0129	dihydroxy-acid dehydratase activity
K08M3_00530	COG3265	gluconokinase activity
K08M3_00540	COG2610	gluconate transmembrane transporter activity
K08M3_00550	COG0800	Aldolase
K08M3_00560	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K08M3_00570	COG0583	DNA-binding transcription factor activity
K08M3_00580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K08M3_00590	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K08M3_00610	COG1522	sequence-specific DNA binding
K08M3_00620	COG5002	protein histidine kinase activity
K08M3_00620	COG5001	Diguanylate cyclase
K08M3_00630	COG0742	ribosomal rna small subunit methyltransferase
K08M3_00650	COG0697	spore germination
K08M3_00660	COG0589	response to stress
K08M3_00670	COG1528	Iron-storage protein
K08M3_00690	COG2081	HI0933 family
K08M3_00750	COG1597	lipid kinase activity
K08M3_00810	COG0628	permease
K08M3_00840	COG1322	Protein conserved in bacteria
K08M3_00850	COG2226	methyltransferase
K08M3_00860	COG3165	ubiquinone biosynthetic process from chorismate
K08M3_00870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K08M3_00900	COG0805	protein transport
K08M3_00910	COG0084	hydrolase, TatD family'
K08M3_00930	COG0456	acetyltransferase
K08M3_00950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K08M3_00950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K08M3_00960	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K08M3_01010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K08M3_01020	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K08M3_01040	COG2204	response regulator
K08M3_01050	COG3852	Histidine kinase
K08M3_01070	COG0174	glutamine synthetase
K08M3_01090	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K08M3_01110	COG1295	ribonuclease BN
K08M3_01120	COG1490	D-aminoacyl-tRNA deacylase activity
K08M3_01130	COG0456	acetyltransferase
K08M3_01150	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K08M3_01160	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K08M3_01170	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K08M3_01180	COG3031	protein transport across the cell outer membrane
K08M3_01200	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K08M3_01210	COG1459	type II secretion system
K08M3_01220	COG2165	general secretion pathway protein
K08M3_01230	COG2165	general secretion pathway protein
K08M3_01240	COG2165	general secretion pathway protein
K08M3_01250	COG4795	General secretion pathway protein
K08M3_01260	COG3156	type II secretion system protein K
K08M3_01270	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K08M3_01280	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K08M3_01300	COG1218	3'(2'),5'-bisphosphate nucleotidase
K08M3_01310	COG0494	nUDIX hydrolase
K08M3_01330	COG1040	competence protein
K08M3_01360	COG2183	response to ionizing radiation
K08M3_01380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K08M3_01400	COG0745	RESPONSE REGULATOR receiver
K08M3_01410	COG2205	protein histidine kinase activity
K08M3_01420	COG2233	PERMEase
K08M3_01430	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K08M3_01440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K08M3_01450	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K08M3_01460	COG1758	RNA polymerase activity
K08M3_01470	COG0194	GDP metabolic process
K08M3_01500	COG0848	biopolymer transport protein
K08M3_01510	COG0811	peptide transport
K08M3_01550	COG4174	ABC transporter (Permease)
K08M3_01560	COG4239	(ABC) transporter, permease
K08M3_01570	COG0747	negative chemotaxis
K08M3_01580	COG0444	Belongs to the ABC transporter superfamily
K08M3_01590	COG4608	Belongs to the ABC transporter superfamily
K08M3_01610	COG1561	YicC-like family, N-terminal region
K08M3_01620	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K08M3_01630	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K08M3_01640	COG1560	Kdo2-lipid A biosynthetic process
K08M3_01650	COG1309	transcriptional regulator
K08M3_01660	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K08M3_01680	COG2003	Belongs to the UPF0758 family
K08M3_01730	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K08M3_01760	COG0463	Glycosyl transferase, family 2
K08M3_01770	COG0859	PFAM glycosyl transferase family 9
K08M3_01780	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K08M3_01790	COG3642	lipopolysaccharide core region biosynthetic process
K08M3_01810	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K08M3_01890	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K08M3_01900	COG1519	Transferase
K08M3_01910	COG0859	PFAM glycosyl transferase family 9
K08M3_01930	COG1560	Kdo2-lipid A biosynthetic process
K08M3_01970	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K08M3_02070	COG0438	transferase activity, transferring glycosyl groups
K08M3_02090	COG0438	transferase activity, transferring glycosyl groups
K08M3_02090	COG0297	glycogen (starch) synthase activity
K08M3_02110	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K08M3_02120	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K08M3_02130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K08M3_02190	COG1215	transferase activity, transferring glycosyl groups
K08M3_02240	COG0149	triose-phosphate isomerase activity
K08M3_02290	COG1494	fructose-1,6-bisphosphatase
K08M3_02310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K08M3_02320	COG1575	Belongs to the MenA family. Type 1 subfamily
K08M3_02380	COG2003	Belongs to the UPF0758 family
K08M3_02410	COG4565	transcriptional regulatory protein
K08M3_02430	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K08M3_02440	COG5016	pyruvate
K08M3_02440	COG0511	ligase activity, forming carbon-carbon bonds
K08M3_02450	COG3630	sodium ion export across plasma membrane
K08M3_02470	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
K08M3_02480	COG3052	prosthetic group binding
K08M3_02490	COG2301	Belongs to the HpcH HpaI aldolase family
K08M3_02500	COG3051	citrate lyase alpha subunit
K08M3_02510	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
K08M3_02520	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
K08M3_02550	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K08M3_02560	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K08M3_02590	COG1609	Transcriptional regulator
K08M3_02600	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K08M3_02610	COG0254	rRNA binding
K08M3_02630	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K08M3_02640	COG0088	Forms part of the polypeptide exit tunnel
K08M3_02660	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K08M3_02670	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K08M3_02680	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K08M3_02690	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K08M3_02710	COG0255	Belongs to the universal ribosomal protein uL29 family
K08M3_02720	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K08M3_02740	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K08M3_02750	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K08M3_02760	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K08M3_02770	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K08M3_02780	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K08M3_02810	COG1841	ribosomal large subunit assembly
K08M3_02830	COG0201	protein transport
K08M3_02850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K08M3_02860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K08M3_02880	COG0202	RNA polymerase activity
K08M3_02890	COG0203	ribosomal protein L17
K08M3_02910	COG0545	Peptidyl-prolyl cis-trans isomerase
K08M3_02930	COG2153	protein acetylation
K08M3_02940	COG0513	Belongs to the DEAD box helicase family
K08M3_02970	COG1648	precorrin-2 dehydrogenase activity
K08M3_02970	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K08M3_02980	COG0175	sulfate reduction
K08M3_02990	COG2895	sulfate adenylyltransferase (ATP) activity
K08M3_03000	COG0471	metal ion transport
K08M3_03000	COG3273	potassium ion transport
K08M3_03010	COG0529	Catalyzes the synthesis of activated sulfate
K08M3_03060	COG4181	ATPase activity
K08M3_03090	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K08M3_03110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K08M3_03120	COG0729	surface antigen
K08M3_03130	COG2911	Protein conserved in bacteria
K08M3_03140	COG2105	PFAM AIG2 family protein
K08M3_03160	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K08M3_03170	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K08M3_03180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K08M3_03190	COG0163	prenyltransferase activity
K08M3_03200	COG4143	(ABC) transporter
K08M3_03210	COG1178	ABC-type Fe3 transport system permease component
K08M3_03220	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K08M3_03230	COG0583	DNA-binding transcription factor activity
K08M3_03240	COG1902	pentaerythritol trinitrate reductase activity
K08M3_03310	COG0142	geranyltranstransferase activity
K08M3_03320	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K08M3_03340	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K08M3_03350	COG2966	Psort location CytoplasmicMembrane, score
K08M3_03370	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K08M3_03380	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K08M3_03390	COG2967	ApaG domain
K08M3_03400	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K08M3_03410	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K08M3_03420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K08M3_03430	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K08M3_03440	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K08M3_03480	COG0473	3-isopropylmalate dehydrogenase activity
K08M3_03490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K08M3_03530	COG0583	DNA-binding transcription factor activity
K08M3_03540	COG1022	Amp-dependent synthetase and ligase
K08M3_03550	COG0028	Belongs to the TPP enzyme family
K08M3_03560	COG0440	acetolactate synthase activity
K08M3_03570	COG3706	GGDEF domain
K08M3_03590	COG0469	pyruvate kinase activity
K08M3_03600	COG1349	DNA-binding transcription factor activity
K08M3_03610	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K08M3_03630	COG2376	Dihydroxyacetone kinase
K08M3_03640	COG1461	Dihydroxyacetone kinase
K08M3_03670	COG3722	fumarate hydratase activity
K08M3_03690	COG2213	PTS system mannitol-specific
K08M3_03690	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K08M3_03750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K08M3_03760	COG0358	DNA primase activity
K08M3_03770	COG1610	YqeY-like protein
K08M3_03780	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K08M3_03790	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K08M3_03800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K08M3_03810	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K08M3_03820	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K08M3_03830	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K08M3_03840	COG1968	undecaprenyl-diphosphatase activity
K08M3_03860	COG3409	Peptidoglycan-binding domain 1 protein
K08M3_03860	COG3267	Type II secretory pathway component ExeA
K08M3_03880	COG0405	Gamma-glutamyltransferase
K08M3_03890	COG4991	sh3 domain protein
K08M3_03900	COG0306	phosphate transporter
K08M3_03910	COG1392	Phosphate transport regulator
K08M3_03920	COG3025	triphosphatase activity
K08M3_03950	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K08M3_03960	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K08M3_03960	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K08M3_03970	COG1538	Outer membrane efflux protein
K08M3_03980	COG0494	nUDIX hydrolase
K08M3_03990	COG3151	Protein conserved in bacteria
K08M3_04010	COG3150	esterase
K08M3_04020	COG0187	DNA topoisomerase II activity
K08M3_04030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K08M3_04040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K08M3_04060	COG3105	Protein conserved in bacteria
K08M3_04070	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K08M3_04090	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K08M3_04100	COG0723	plastoquinol--plastocyanin reductase activity
K08M3_04110	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K08M3_04120	COG2857	Cytochrome c1
K08M3_04130	COG0625	glutathione transferase activity
K08M3_04140	COG2969	positive regulation of protein catabolic process
K08M3_04170	COG2823	Periplasmic or secreted lipoprotein
K08M3_04180	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K08M3_04210	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K08M3_04230	COG3116	cell division
K08M3_04240	COG0768	penicillin binding
K08M3_04250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K08M3_04260	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K08M3_04270	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K08M3_04280	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K08M3_04290	COG0772	Belongs to the SEDS family
K08M3_04320	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K08M3_04330	COG0849	cell division
K08M3_04340	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K08M3_04350	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K08M3_04370	COG0653	protein targeting
K08M3_04380	COG0494	nUDIX hydrolase
K08M3_04400	COG0505	Belongs to the CarA family
K08M3_04410	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K08M3_04440	COG0730	response to heat
K08M3_04450	COG0583	DNA-binding transcription factor activity
K08M3_04460	COG2860	membrane
K08M3_04490	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K08M3_04510	COG0493	'glutamate synthase
K08M3_04520	COG0070	glutamate synthase
K08M3_04520	COG0067	glutamate synthase
K08M3_04520	COG0069	glutamate synthase activity
K08M3_04540	COG0070	glutamate synthase
K08M3_04540	COG0069	glutamate synthase activity
K08M3_04540	COG0067	glutamate synthase
K08M3_04550	COG1242	4 iron, 4 sulfur cluster binding
K08M3_04560	COG5001	Diguanylate cyclase
K08M3_04560	COG3706	GGDEF domain
K08M3_04560	COG4251	negative regulation of phosphorylation
K08M3_04560	COG2203	Gaf domain
K08M3_04570	COG5002	protein histidine kinase activity
K08M3_04570	COG2198	Histidine kinase
K08M3_04570	COG0784	Response regulator, receiver
K08M3_04590	COG0745	RESPONSE REGULATOR receiver
K08M3_04610	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K08M3_04640	COG0083	homoserine kinase activity
K08M3_04650	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K08M3_04670	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
K08M3_04680	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K08M3_04690	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K08M3_04720	COG1115	amino acid carrier protein
K08M3_04730	COG3022	response to hydroperoxide
K08M3_04740	COG0513	Belongs to the DEAD box helicase family
K08M3_04750	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K08M3_04770	COG0716	FMN binding
K08M3_04790	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K08M3_04800	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K08M3_04810	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K08M3_04830	COG2204	response regulator
K08M3_04860	COG0667	Aldo Keto reductase
K08M3_04910	COG0730	response to heat
K08M3_04930	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K08M3_04950	COG1283	sodium-dependent phosphate transmembrane transporter activity
K08M3_04960	COG0583	DNA-binding transcription factor activity
K08M3_04970	COG0640	Transcriptional regulator
K08M3_04980	COG0268	Binds directly to 16S ribosomal RNA
K08M3_04990	COG0728	peptidoglycan biosynthetic process
K08M3_05000	COG0196	riboflavin kinase activity
K08M3_05030	COG1047	Peptidyl-prolyl cis-trans
K08M3_05040	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K08M3_05060	COG3279	Response regulator of the LytR AlgR family
K08M3_05070	COG3275	phosphorelay sensor kinase activity
K08M3_05080	COG1966	Carbon starvation protein
K08M3_05120	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K08M3_05130	COG1472	Belongs to the glycosyl hydrolase 3 family
K08M3_05140	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K08M3_05150	COG1605	Chorismate mutase
K08M3_05150	COG0287	Prephenate dehydrogenase
K08M3_05160	COG0739	heme binding
K08M3_05180	COG0488	(ABC) transporter
K08M3_05200	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
K08M3_05210	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
K08M3_05220	COG1605	Chorismate mutase
K08M3_05220	COG0077	Prephenate dehydratase
K08M3_05230	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K08M3_05250	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K08M3_05260	COG0564	pseudouridine synthase activity
K08M3_05280	COG0542	response to heat
K08M3_05410	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K08M3_05430	COG2974	May be involved in recombination
K08M3_05440	COG0745	RESPONSE REGULATOR receiver
K08M3_05450	COG5002	protein histidine kinase activity
K08M3_05470	COG0248	Ppx GppA phosphatase
K08M3_05480	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K08M3_05490	COG0573	inorganic phosphate transmembrane transporter activity
K08M3_05500	COG0581	inorganic phosphate transmembrane transporter activity
K08M3_05510	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K08M3_05520	COG0704	Plays a role in the regulation of phosphate uptake
K08M3_05540	COG3142	Participates in the control of copper homeostasis
K08M3_05550	COG0450	alkyl hydroperoxide reductase
K08M3_05560	COG0583	DNA-binding transcription factor activity
K08M3_05570	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K08M3_05590	COG0517	IMP dehydrogenase activity
K08M3_05610	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K08M3_05630	COG1862	Preprotein translocase
K08M3_05640	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K08M3_05650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K08M3_05680	COG0483	inositol monophosphate 1-phosphatase activity
K08M3_05690	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
K08M3_05710	COG1104	cysteine desulfurase activity
K08M3_05720	COG0822	iron-sulfur transferase activity
K08M3_05750	COG0443	Heat shock 70 kDa protein
K08M3_05760	COG0633	Ferredoxin
K08M3_05770	COG2975	iron-sulfur cluster assembly
K08M3_05790	COG0105	UTP biosynthetic process
K08M3_05820	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K08M3_05830	COG0124	histidyl-tRNA synthetase
K08M3_05840	COG2976	Protein conserved in bacteria
K08M3_05850	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K08M3_05860	COG1160	GTP binding
K08M3_05900	COG0516	GMP reductase activity
K08M3_05900	COG0517	IMP dehydrogenase activity
K08M3_05920	COG0582	viral genome integration into host DNA
K08M3_06060	COG1757	Na H antiporter
K08M3_06080	COG1584	GPR1 FUN34 yaaH family protein
K08M3_06090	COG1115	amino acid carrier protein
K08M3_06120	COG2873	o-acetylhomoserine
K08M3_06130	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K08M3_06170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K08M3_06170	COG3153	acetyltransferase
K08M3_06180	COG0583	DNA-binding transcription factor activity
K08M3_06220	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K08M3_06230	COG2867	negative regulation of translational initiation
K08M3_06240	COG2914	Belongs to the UPF0125 (RnfH) family
K08M3_06250	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K08M3_06270	COG0497	DNA recombination
K08M3_06290	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K08M3_06300	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K08M3_06320	COG1301	dicarboxylic acid transport
K08M3_06340	COG0484	heat shock protein binding
K08M3_06400	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K08M3_06410	COG0590	tRNA wobble adenosine to inosine editing
K08M3_06420	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K08M3_06430	COG0047	phosphoribosylformylglycinamidine synthase activity
K08M3_06430	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K08M3_06490	COG2195	Cleaves the N-terminal amino acid of tripeptides
K08M3_06500	COG2252	PERMEase
K08M3_06510	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K08M3_06540	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K08M3_06550	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K08M3_06560	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K08M3_06570	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K08M3_06570	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K08M3_06620	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K08M3_06630	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K08M3_06640	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K08M3_06650	COG0142	geranyltranstransferase activity
K08M3_06660	COG1722	exodeoxyribonuclease VII activity
K08M3_06670	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K08M3_06690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K08M3_06690	COG0301	tRNA thio-modification
K08M3_06710	COG0583	DNA-binding transcription factor activity
K08M3_06730	COG2363	Small membrane protein
K08M3_06750	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K08M3_06760	COG1611	Belongs to the LOG family
K08M3_06770	COG0745	RESPONSE REGULATOR receiver
K08M3_06770	COG3706	GGDEF domain
K08M3_06790	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K08M3_06790	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K08M3_06810	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
K08M3_06820	COG1464	Belongs to the NlpA lipoprotein family
K08M3_06830	COG2011	ABC-type metal ion transport system permease component
K08M3_06840	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K08M3_06850	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K08M3_06870	COG1263	PTS System
K08M3_06870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K08M3_06880	COG0366	Alpha amylase catalytic
K08M3_06910	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K08M3_06920	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K08M3_06930	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K08M3_06940	COG0321	lipoyl(octanoyl) transferase activity
K08M3_06960	COG1686	Belongs to the peptidase S11 family
K08M3_06970	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K08M3_06980	COG0772	Belongs to the SEDS family
K08M3_06990	COG0768	penicillin binding
K08M3_07000	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K08M3_07010	COG0799	negative regulation of ribosome biogenesis
K08M3_07020	COG1466	dna polymerase III delta subunit
K08M3_07030	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
K08M3_07040	COG0495	leucyl-tRNA aminoacylation
K08M3_07050	COG2888	peptidyl-tyrosine sulfation
K08M3_07060	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K08M3_07070	COG4535	Mg2 and Co2 transporter CorC
K08M3_07080	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K08M3_07090	COG1702	phosphate starvation-inducible protein PhoH
K08M3_07100	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K08M3_07110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K08M3_07320	COG0012	GTP binding
K08M3_07330	COG0193	aminoacyl-tRNA hydrolase activity
K08M3_07340	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K08M3_07350	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K08M3_07360	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K08M3_07370	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K08M3_07390	COG2890	protein-(glutamine-N5) methyltransferase activity
K08M3_07400	COG3094	Invasion gene expression up-regulator, SirB
K08M3_07410	COG2912	Transglutaminase-like superfamily
K08M3_07420	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K08M3_07430	COG0737	Belongs to the 5'-nucleotidase family
K08M3_07440	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K08M3_07450	COG1187	pseudouridine synthase activity
K08M3_07460	COG2840	Smr protein MutS2
K08M3_07540	COG2217	Heavy metal translocating P-type atpase
K08M3_07540	COG2608	mercury ion transmembrane transporter activity
K08M3_07560	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K08M3_07670	COG0784	Response regulator, receiver
K08M3_07670	COG0835	chemotaxis
K08M3_07680	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K08M3_07690	COG1815	bacterial-type flagellum-dependent cell motility
K08M3_07700	COG1558	bacterial-type flagellum-dependent cell motility
K08M3_07710	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K08M3_07720	COG1749	Flagellar hook protein flgE
K08M3_07730	COG4787	bacterial-type flagellum-dependent cell motility
K08M3_07740	COG4786	Flagellar basal body rod
K08M3_07750	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K08M3_07760	COG1706	bacterial-type flagellum-dependent cell motility
K08M3_07770	COG3951	Flagellar rod assembly protein muramidase FlgJ
K08M3_07770	COG1705	Flagellar rod assembly protein muramidase FlgJ
K08M3_07790	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K08M3_07800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K08M3_07810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K08M3_07820	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K08M3_07830	COG2190	(PTS) system
K08M3_07840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K08M3_07860	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K08M3_07870	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K08M3_07880	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
K08M3_07890	COG3115	cell septum assembly
K08M3_07900	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K08M3_07950	COG0330	HflC and HflK could
K08M3_07960	COG2194	sulfuric ester hydrolase activity
K08M3_08000	COG1192	Involved in chromosome partitioning
K08M3_08010	COG1215	transferase activity, transferring glycosyl groups
K08M3_08030	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
K08M3_08040	COG0457	Tetratricopeptide repeat
K08M3_08040	COG3118	belongs to the thioredoxin family
K08M3_08050	COG3118	belongs to the thioredoxin family
K08M3_08060	COG0300	oxidoreductase activity
K08M3_08070	COG1090	epimerase
K08M3_08130	COG0622	Phosphoesterase
K08M3_08170	COG3710	Transcriptional regulator
K08M3_08180	COG0326	Molecular chaperone. Has ATPase activity
K08M3_08200	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K08M3_08210	COG3104	oligopeptide transport
K08M3_08220	COG0250	Participates in transcription elongation, termination and antitermination
K08M3_08230	COG0367	asparagine synthase
K08M3_08240	COG4651	solute:proton antiporter activity
K08M3_08240	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K08M3_08250	COG1940	carbohydrate kinase activity
K08M3_08250	COG1846	Transcriptional regulator
K08M3_08260	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K08M3_08270	COG2190	(PTS) system
K08M3_08270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K08M3_08270	COG1263	PTS System
K08M3_08280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K08M3_08290	COG0735	belongs to the Fur family
K08M3_08310	COG0716	FMN binding
K08M3_08330	COG0596	Alpha beta hydrolase
K08M3_08340	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
K08M3_08350	COG0033	Phosphoglucomutase
K08M3_08370	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K08M3_08390	COG2009	succinate dehydrogenase
K08M3_08400	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K08M3_08410	COG1053	succinate dehydrogenase
K08M3_08420	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K08M3_08430	COG0567	Dehydrogenase, E1 component
K08M3_08440	COG0508	dehydrogenase complex catalyzes the overall conversion of
K08M3_08450	COG0045	succinate-CoA ligase (ADP-forming) activity
K08M3_08470	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K08M3_08480	COG1121	(ABC) transporter
K08M3_08490	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
K08M3_08500	COG4977	sequence-specific DNA binding
K08M3_08510	COG1918	ferrous iron import across plasma membrane
K08M3_08560	COG0018	arginyl-trna synthetase
K08M3_08570	COG3102	Protein conserved in bacteria
K08M3_08600	COG0788	formyltetrahydrofolate deformylase activity
K08M3_08610	COG1199	ATP-dependent helicase activity
K08M3_08620	COG1214	PFAM Peptidase M22, glycoprotease
K08M3_08640	COG3065	identical protein binding
K08M3_08650	COG2267	carboxylic ester hydrolase activity
K08M3_08660	COG0318	PFAM AMP-dependent synthetase and ligase
K08M3_08670	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K08M3_08690	COG2894	cell division
K08M3_08700	COG0850	regulation of cytokinetic process
K08M3_08710	COG3100	YcgL domain-containing protein
K08M3_08720	COG2951	lytic endotransglycosylase activity
K08M3_08740	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K08M3_08750	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K08M3_08770	COG2226	methyltransferase
K08M3_08790	COG1028	Short-chain dehydrogenase reductase Sdr
K08M3_08800	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K08M3_08810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K08M3_08860	COG2986	histidine ammonia-lyase
K08M3_08870	COG1216	Glycosyl transferase, family 2
K08M3_08880	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K08M3_08910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K08M3_08920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K08M3_08990	COG0513	Belongs to the DEAD box helicase family
K08M3_09000	COG0569	domain protein
K08M3_09010	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K08M3_09050	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K08M3_09060	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K08M3_09070	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K08M3_09080	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K08M3_09120	COG0544	peptidyl-prolyl cis-trans isomerase activity
K08M3_09140	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K08M3_09150	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K08M3_09160	COG0776	regulation of translation
K08M3_09170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K08M3_09180	COG1555	photosystem II stabilization
K08M3_09210	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K08M3_09220	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K08M3_09230	COG0436	Aminotransferase
K08M3_09240	COG1169	isochorismate synthase
K08M3_09250	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K08M3_09270	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K08M3_09280	COG1441	menaquinone biosynthetic process
K08M3_09310	COG2855	membrane
K08M3_09320	COG0477	Major facilitator Superfamily
K08M3_09410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K08M3_09420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K08M3_09450	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K08M3_09460	COG1522	sequence-specific DNA binding
K08M3_09480	COG1946	Acyl-CoA thioesterase
K08M3_09490	COG3126	Type III secretion system lipoprotein chaperone (YscW)
K08M3_09520	COG3706	GGDEF domain
K08M3_09530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K08M3_09540	COG0516	GMP reductase activity
K08M3_09540	COG0517	IMP dehydrogenase activity
K08M3_09590	COG0537	adenosine 5'-monophosphoramidase activity
K08M3_09640	COG3150	esterase
K08M3_09650	COG1252	NADH dehydrogenase
K08M3_09680	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K08M3_09700	COG4591	ABC-type transport system involved in lipoprotein release permease component
K08M3_09710	COG1136	(ABC) transporter
K08M3_09720	COG4591	ABC-type transport system involved in lipoprotein release permease component
K08M3_09740	COG0658	competence protein
K08M3_09740	COG2333	competence protein COMEC
K08M3_09750	COG1132	(ABC) transporter
K08M3_09790	COG2719	SpoVR family
K08M3_09800	COG2718	Belongs to the UPF0229 family
K08M3_09810	COG2766	serine protein kinase
K08M3_09820	COG3013	Belongs to the UPF0304 family
K08M3_09840	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K08M3_09860	COG1882	Formate acetyltransferase
K08M3_09910	COG4215	(ABC) transporter
K08M3_09940	COG0708	Exodeoxyribonuclease III
K08M3_09960	COG3923	Primosomal replication protein n
K08M3_09970	COG0730	response to heat
K08M3_09980	COG1199	ATP-dependent helicase activity
K08M3_10000	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K08M3_10010	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K08M3_10020	COG1187	pseudouridine synthase activity
K08M3_10040	COG1278	Cold shock
K08M3_10050	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K08M3_10060	COG0542	response to heat
K08M3_10070	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K08M3_10080	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K08M3_10090	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K08M3_10130	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K08M3_10140	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K08M3_10150	COG0297	glycogen (starch) synthase activity
K08M3_10190	COG3070	regulator of competence-specific genes
K08M3_10200	COG1609	Transcriptional regulator
K08M3_10210	COG3381	protein complex oligomerization
K08M3_10220	COG0745	RESPONSE REGULATOR receiver
K08M3_10230	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K08M3_10240	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K08M3_10250	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
K08M3_10260	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
K08M3_10270	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K08M3_10310	COG0189	ligase activity
K08M3_10310	COG4067	protein conserved in archaea
K08M3_10320	COG0500	methyltransferase
K08M3_10340	COG1801	Protein of unknown function DUF72
K08M3_10360	COG0217	transcriptional regulatory protein
K08M3_10370	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K08M3_10380	COG0632	four-way junction helicase activity
K08M3_10390	COG2255	four-way junction helicase activity
K08M3_10400	COG1271	oxidase subunit
K08M3_10410	COG1294	oxidase, subunit
K08M3_10420	COG4890	Cyd operon protein YbgT
K08M3_10440	COG0824	Thioesterase
K08M3_10450	COG0811	peptide transport
K08M3_10480	COG0823	Involved in the tonB-independent uptake of proteins
K08M3_10490	COG2885	chlorophyll binding
K08M3_10500	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
K08M3_10590	COG0217	transcriptional regulatory protein
K08M3_10600	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K08M3_10610	COG0632	four-way junction helicase activity
K08M3_10620	COG2255	four-way junction helicase activity
K08M3_10630	COG1271	oxidase subunit
K08M3_10640	COG1294	oxidase, subunit
K08M3_10650	COG4890	Cyd operon protein YbgT
K08M3_10670	COG0824	Thioesterase
K08M3_10680	COG0811	peptide transport
K08M3_10710	COG0823	Involved in the tonB-independent uptake of proteins
K08M3_10720	COG2885	chlorophyll binding
K08M3_10730	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
K08M3_10740	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K08M3_10760	COG3766	membrane
K08M3_10780	COG0754	glutathionylspermidine amidase activity
K08M3_10800	COG0784	Response regulator, receiver
K08M3_10800	COG5002	protein histidine kinase activity
K08M3_10840	COG1294	oxidase, subunit
K08M3_10850	COG1271	oxidase subunit
K08M3_10900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K08M3_10910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K08M3_10960	COG3568	Endonuclease Exonuclease Phosphatase
K08M3_11010	COG0583	DNA-binding transcription factor activity
K08M3_11030	COG0686	Belongs to the AlaDH PNT family
K08M3_11050	COG1674	ftsk spoiiie
K08M3_11070	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K08M3_11110	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K08M3_11120	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K08M3_11160	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K08M3_11200	COG0300	oxidoreductase activity
K08M3_11230	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K08M3_11250	COG2268	Band 7 protein
K08M3_11270	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K08M3_11280	COG2915	High frequency lysogenization protein hflD homolog
K08M3_11310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K08M3_11330	COG1757	Na H antiporter
K08M3_11350	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K08M3_11370	COG0131	Imidazoleglycerol-phosphate dehydratase
K08M3_11370	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K08M3_11380	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K08M3_11390	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K08M3_11400	COG0107	imidazoleglycerol-phosphate synthase activity
K08M3_11410	COG0140	phosphoribosyl-ATP diphosphatase activity
K08M3_11410	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K08M3_11420	COG3012	SEC-C Motif Domain Protein
K08M3_11430	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K08M3_11440	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K08M3_11450	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K08M3_11460	COG0215	cysteine-tRNA ligase activity
K08M3_11470	COG1435	thymidine kinase activity
K08M3_11530	COG2116	formate transmembrane transporter activity
K08M3_11550	COG0390	transport system, permease component
K08M3_11560	COG4459	periplasmic nitrate reductase
K08M3_11570	COG3005	denitrification pathway
K08M3_11580	COG0243	molybdopterin cofactor binding
K08M3_11610	COG1227	inorganic diphosphatase activity
K08M3_11630	COG4172	Belongs to the ABC transporter superfamily
K08M3_11650	COG4171	peptide transport system, permease
K08M3_11660	COG4168	peptide transport system, permease
K08M3_11680	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K08M3_11690	COG1842	Phage shock protein A
K08M3_11710	COG1983	PspC domain protein
K08M3_11750	COG2818	Glycosylase
K08M3_11760	COG5380	lipid catabolic process
K08M3_11770	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
K08M3_11780	COG0626	cystathionine gamma-synthase activity
K08M3_11800	COG0733	neurotransmitter:sodium symporter activity
K08M3_11810	COG0564	pseudouridine synthase activity
K08M3_11830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K08M3_11840	COG1151	hydroxylamine reductase activity
K08M3_11850	COG3604	Transcriptional regulator
K08M3_11870	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K08M3_11880	COG4136	ATPase activity
K08M3_11890	COG4135	transport system, permease component
K08M3_11900	COG4134	Bacterial extracellular solute-binding protein
K08M3_11920	COG3313	Fe-S protein
K08M3_11960	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K08M3_11970	COG2205	protein histidine kinase activity
K08M3_11980	COG0745	RESPONSE REGULATOR receiver
K08M3_12000	COG1061	Type III restriction enzyme res subunit
K08M3_12010	COG1187	pseudouridine synthase activity
K08M3_12020	COG2814	Major facilitator Superfamily
K08M3_12040	COG0702	epimerase
K08M3_12050	COG0534	Mate efflux family protein
K08M3_12090	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K08M3_12110	COG1960	acyl-CoA dehydrogenase activity
K08M3_12120	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K08M3_12130	COG2985	domain, Protein
K08M3_12130	COG3273	potassium ion transport
K08M3_12140	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K08M3_12170	COG1737	Transcriptional regulator
K08M3_12180	COG0076	glutamate decarboxylase activity
K08M3_12200	COG2431	L-lysine efflux transmembrane transporter activity
K08M3_12220	COG3070	regulator of competence-specific genes
K08M3_12260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K08M3_12260	COG4191	Histidine kinase
K08M3_12280	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K08M3_12300	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K08M3_12310	COG4988	ABC transporter
K08M3_12320	COG0492	ferredoxin-NADP+ reductase activity
K08M3_12360	COG0745	RESPONSE REGULATOR receiver
K08M3_12360	COG3706	GGDEF domain
K08M3_12370	COG0471	metal ion transport
K08M3_12380	COG2949	membrane
K08M3_12390	COG0281	malic enzyme
K08M3_12400	COG1643	Atp-dependent helicase
K08M3_12430	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K08M3_12500	COG0247	lactate metabolic process
K08M3_12500	COG0277	FAD linked oxidase domain protein
K08M3_12530	COG2986	histidine ammonia-lyase
K08M3_12540	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K08M3_12550	COG0010	Belongs to the arginase family
K08M3_12560	COG1228	amidohydrolase
K08M3_12600	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K08M3_12620	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K08M3_12640	COG0393	Putative heavy-metal-binding
K08M3_12710	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K08M3_12720	COG0072	phenylalanine-tRNA ligase activity
K08M3_12720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K08M3_12740	COG0776	regulation of translation
K08M3_12760	COG0500	methyltransferase
K08M3_12770	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K08M3_12780	COG0295	cytidine deaminase activity
K08M3_12790	COG1346	cytolysis
K08M3_12800	COG1380	Effector of murein hydrolase LrgA
K08M3_12810	COG2925	Exonuclease
K08M3_12930	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K08M3_12990	COG1484	DNA-dependent DNA replication
K08M3_13290	COG0702	epimerase
K08M3_13300	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K08M3_13310	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K08M3_13350	COG2988	succinylglutamate desuccinylase activity
K08M3_13360	COG4139	cobalamin transport
K08M3_13370	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
K08M3_13410	COG0583	DNA-binding transcription factor activity
K08M3_13430	COG1451	nucleotide metabolic process
K08M3_13440	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
K08M3_13500	COG3938	Belongs to the proline racemase family
K08M3_13530	COG2423	ornithine cyclodeaminase activity
K08M3_13540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K08M3_13550	COG3842	ATPase activity
K08M3_13560	COG1176	ABC-type spermidine putrescine transport system, permease component I
K08M3_13570	COG1177	transmembrane transport
K08M3_13590	COG3291	Pkd domain containing protein
K08M3_13620	COG0444	Belongs to the ABC transporter superfamily
K08M3_13630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K08M3_13640	COG0601	transmembrane transport
K08M3_13660	COG2195	Cleaves the N-terminal amino acid of tripeptides
K08M3_13680	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K08M3_13700	COG0625	glutathione transferase activity
K08M3_13800	COG3755	Protein conserved in bacteria
K08M3_13850	COG1742	UPF0060 membrane protein
K08M3_13880	COG1757	Na H antiporter
K08M3_13890	COG0174	glutamine synthetase
K08M3_13900	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K08M3_13910	COG1917	Cupin 2, conserved barrel domain protein
K08M3_13910	COG1396	sequence-specific DNA binding
K08M3_13920	COG1012	belongs to the aldehyde dehydrogenase family
K08M3_13930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K08M3_13950	COG2957	Belongs to the agmatine deiminase family
K08M3_13960	COG1012	belongs to the aldehyde dehydrogenase family
K08M3_13970	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K08M3_13980	COG2200	EAL domain
K08M3_14000	COG1846	Transcriptional regulator
K08M3_14010	COG2315	Protein conserved in bacteria
K08M3_14090	COG3063	Type IV pilus biogenesis stability protein PilW
K08M3_14100	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K08M3_14130	COG1560	Kdo2-lipid A biosynthetic process
K08M3_14150	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K08M3_14400	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K08M3_14410	COG1280	lysine exporter protein (LysE YggA)
K08M3_14430	COG1115	amino acid carrier protein
K08M3_14480	COG1368	sulfuric ester hydrolase activity
K08M3_14490	COG2113	Glycine betaine
K08M3_14500	COG4176	ABC-type proline glycine betaine transport system permease component
K08M3_14510	COG4175	Glycine betaine
K08M3_14540	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K08M3_14550	COG0456	acetyltransferase
K08M3_14560	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K08M3_14570	COG0662	Cupin 2, conserved barrel domain protein
K08M3_14580	COG0527	aspartate kinase activity
K08M3_14590	COG3119	arylsulfatase activity
K08M3_14620	COG0641	radical SAM
K08M3_14650	COG3119	arylsulfatase activity
K08M3_14700	COG1538	Outer membrane efflux protein
K08M3_14730	COG1349	DNA-binding transcription factor activity
K08M3_14740	COG0673	inositol 2-dehydrogenase activity
K08M3_14750	COG4702	Belongs to the UPF0303 family
K08M3_14760	COG3706	GGDEF domain
K08M3_14760	COG0745	RESPONSE REGULATOR receiver
K08M3_14800	COG0471	metal ion transport
K08M3_14830	COG5001	Diguanylate cyclase
K08M3_14830	COG3300	MHYT domain
K08M3_14860	COG1328	CTP reductase activity
K08M3_14870	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K08M3_14890	COG0861	Integral membrane protein TerC family
K08M3_14910	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K08M3_14930	COG0814	amino acid
K08M3_14960	COG1120	ATPase activity
K08M3_14970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K08M3_14990	COG4774	siderophore transport
K08M3_15010	COG1132	(ABC) transporter
K08M3_15020	COG1132	(ABC) transporter
K08M3_15050	COG0583	DNA-binding transcription factor activity
K08M3_15100	COG0443	Heat shock 70 kDa protein
K08M3_15110	COG0443	Heat shock 70 kDa protein
K08M3_15210	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K08M3_15220	COG1643	Atp-dependent helicase
K08M3_15250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K08M3_15270	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K08M3_15280	COG1215	transferase activity, transferring glycosyl groups
K08M3_15290	COG0438	transferase activity, transferring glycosyl groups
K08M3_15350	COG0438	transferase activity, transferring glycosyl groups
K08M3_15360	COG0438	transferase activity, transferring glycosyl groups
K08M3_15370	COG2204	response regulator
K08M3_15440	COG1793	dna ligase
K08M3_15460	COG0534	Mate efflux family protein
K08M3_15470	COG0307	riboflavin synthase, alpha
K08M3_15510	COG3706	GGDEF domain
K08M3_15530	COG0791	NLP P60 protein
K08M3_15610	COG1940	carbohydrate kinase activity
K08M3_15640	COG0746	molybdenum cofactor guanylyltransferase activity
K08M3_15650	COG3842	ATPase activity
K08M3_15680	COG2204	response regulator
K08M3_15690	COG4191	Histidine kinase
K08M3_15700	COG0488	(ABC) transporter
K08M3_15720	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K08M3_15760	COG3381	protein complex oligomerization
K08M3_15780	COG0243	molybdopterin cofactor binding
K08M3_15780	COG3383	formate dehydrogenase (NAD+) activity
K08M3_15790	COG0437	4 iron, 4 sulfur cluster binding
K08M3_15840	COG0004	ammonium transporteR
K08M3_15860	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K08M3_15870	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K08M3_15880	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K08M3_15890	COG1177	transmembrane transport
K08M3_15900	COG1176	ABC-type spermidine putrescine transport system, permease component I
K08M3_15910	COG3842	ATPase activity
K08M3_15960	COG0589	response to stress
K08M3_15970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K08M3_16000	COG2217	Heavy metal translocating P-type atpase
K08M3_16020	COG2010	Cytochrome c
K08M3_16050	COG3278	Belongs to the heme-copper respiratory oxidase family
K08M3_16080	COG0784	Response regulator, receiver
K08M3_16080	COG2205	protein histidine kinase activity
K08M3_16110	COG3120	sequence-specific DNA binding
K08M3_16120	COG1067	ATP-dependent peptidase activity
K08M3_16130	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K08M3_16180	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K08M3_16180	COG0116	Belongs to the methyltransferase superfamily
K08M3_16200	COG0167	dihydroorotate dehydrogenase activity
K08M3_16210	COG2902	Dehydrogenase
K08M3_16220	COG0308	aminopeptidase N
K08M3_16250	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
K08M3_16260	COG1956	GAF domain-containing protein
K08M3_16270	COG1132	(ABC) transporter
K08M3_16280	COG2995	paraquat-inducible protein a
K08M3_16290	COG3008	intermembrane lipid transfer
K08M3_16340	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K08M3_16350	COG1666	GTP binding
K08M3_16370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K08M3_16390	COG4597	amino acid ABC transporter
K08M3_16400	COG0765	amino acid transport
K08M3_16410	COG1126	abc transporter atp-binding protein
K08M3_16420	COG0670	Belongs to the BI1 family
K08M3_16440	COG2920	part of a sulfur-relay system
K08M3_16450	COG1254	Belongs to the acylphosphatase family
K08M3_16460	COG0840	transmembrane signaling receptor activity
K08M3_16500	COG2885	chlorophyll binding
K08M3_16550	COG2199	diguanylate cyclase activity
K08M3_16550	COG2203	Gaf domain
K08M3_16560	COG1414	Transcriptional regulator
K08M3_16580	COG0656	L-ascorbic acid biosynthetic process
K08M3_16590	COG0583	DNA-binding transcription factor activity
K08M3_16610	COG0583	DNA-binding transcription factor activity
K08M3_16620	COG2814	Major facilitator Superfamily
K08M3_16660	COG1335	isochorismatase
K08M3_16670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K08M3_16700	COG1410	methionine synthase
K08M3_16700	COG0646	methionine synthase
K08M3_16710	COG1126	abc transporter atp-binding protein
K08M3_16720	COG0765	amino acid transport
K08M3_16730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K08M3_16770	COG0583	DNA-binding transcription factor activity
K08M3_16800	COG0583	DNA-binding transcription factor activity
K08M3_16820	COG0583	DNA-binding transcription factor activity
K08M3_16850	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K08M3_16860	COG0602	queuosine metabolic process
K08M3_16870	COG0561	phosphatase activity
K08M3_16920	COG2828	Protein conserved in bacteria
K08M3_16940	COG0372	Belongs to the citrate synthase family
K08M3_16950	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K08M3_17020	COG0730	response to heat
K08M3_17060	COG0457	Tetratricopeptide repeat
K08M3_17190	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K08M3_17200	COG4790	Type iii secretion
K08M3_17210	COG4794	Type iii secretion
K08M3_17220	COG4791	protein targeting
K08M3_17230	COG4792	protein secretion
K08M3_17240	COG2207	Transcriptional regulator
K08M3_17300	COG3177	Filamentation induced by cAMP protein fic
K08M3_17340	COG4669	(LipO)protein
K08M3_17480	COG1012	belongs to the aldehyde dehydrogenase family
K08M3_17490	COG3284	Transcriptional regulator
K08M3_17520	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K08M3_17530	COG0363	glucosamine-6-phosphate deaminase activity
K08M3_17540	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K08M3_17550	COG2207	Transcriptional regulator
K08M3_17570	COG4565	transcriptional regulatory protein
K08M3_17580	COG3290	protein histidine kinase activity
K08M3_17610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K08M3_17670	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K08M3_17690	COG2985	domain, Protein
K08M3_17760	COG2272	Belongs to the type-B carboxylesterase lipase family
K08M3_17790	COG0729	surface antigen
K08M3_17810	COG1280	lysine exporter protein (LysE YggA)
K08M3_17820	COG1280	lysine exporter protein (LysE YggA)
K08M3_17830	COG5507	3-demethylubiquinone-9 3-methyltransferase
K08M3_17870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K08M3_17890	COG0110	maltose O-acetyltransferase activity
K08M3_17970	COG2801	Transposase and inactivated derivatives
K08M3_18020	COG1683	Conserved Protein
K08M3_18140	COG2801	Transposase and inactivated derivatives
K08M3_18190	COG1403	HNH endonuclease
K08M3_18320	COG4974	Belongs to the 'phage' integrase family
K08M3_18350	COG3706	GGDEF domain
K08M3_18370	COG2985	domain, Protein
K08M3_18380	COG0076	glutamate decarboxylase activity
K08M3_18390	COG0598	Magnesium transport protein CorA
K08M3_18410	COG0387	Pfam Sodium calcium exchanger
K08M3_18420	COG0387	Pfam Sodium calcium exchanger
K08M3_18450	COG1289	transmembrane transporter activity
K08M3_18480	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K08M3_18500	COG2985	domain, Protein
K08M3_18510	COG0025	NhaP-type Na H and K H
K08M3_18530	COG2433	Pfam Transposase IS66
K08M3_18550	COG3302	dmso reductase anchor subunit
K08M3_18560	COG0437	4 iron, 4 sulfur cluster binding
K08M3_18570	COG0243	molybdopterin cofactor binding
K08M3_18590	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K08M3_18590	COG2221	Nitrite and sulphite reductase 4Fe-4S
K08M3_18600	COG0784	Response regulator, receiver
K08M3_18600	COG2205	protein histidine kinase activity
K08M3_18690	COG2204	response regulator
K08M3_18740	COG3477	response to acidic pH
K08M3_18750	COG2199	diguanylate cyclase activity
K08M3_18750	COG3287	FIST C domain
K08M3_18750	COG2200	EAL domain
K08M3_18760	COG2197	response regulator
K08M3_18910	COG1472	Belongs to the glycosyl hydrolase 3 family
K08M3_18930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K08M3_18930	COG2205	protein histidine kinase activity
K08M3_18940	COG2197	response regulator
K08M3_19070	COG1335	isochorismatase
K08M3_19200	COG4628	conserved protein (DUF2132)
K08M3_19260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K08M3_19280	COG3768	UPF0283 membrane protein
K08M3_19290	COG3106	COG3106 Predicted ATPase
K08M3_19320	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K08M3_19330	COG2205	protein histidine kinase activity
K08M3_19330	COG0784	Response regulator, receiver
K08M3_19350	COG0494	nUDIX hydrolase
K08M3_19360	COG0814	amino acid
K08M3_19370	COG1760	l-serine dehydratase
K08M3_19380	COG2200	EAL domain
K08M3_19400	COG0720	synthase
K08M3_19410	COG0840	transmembrane signaling receptor activity
K08M3_19420	COG0017	Asparaginyl-tRNA synthetase
K08M3_19440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K08M3_19470	COG1448	Aminotransferase
K08M3_19510	COG0840	transmembrane signaling receptor activity
K08M3_19520	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K08M3_19580	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K08M3_19610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K08M3_19620	COG3108	Peptidase M15
K08M3_19630	COG2989	Protein conserved in bacteria
K08M3_19680	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K08M3_19700	COG3088	subunit of a heme lyase
K08M3_19700	COG4235	cytochrome complex assembly
K08M3_19720	COG1138	Cytochrome C-type biogenesis protein
K08M3_19730	COG3301	Polysulphide reductase, NrfD
K08M3_19740	COG0437	4 iron, 4 sulfur cluster binding
K08M3_19760	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
K08M3_19800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K08M3_19810	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K08M3_19820	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K08M3_19870	COG0019	diaminopimelate decarboxylase activity
K08M3_19950	COG0322	excinuclease ABC activity
K08M3_19960	COG2197	response regulator
K08M3_19970	COG0417	DNA replication proofreading
K08M3_20010	COG1187	pseudouridine synthase activity
K08M3_20030	COG0009	L-threonylcarbamoyladenylate synthase
K08M3_20040	COG0613	PHP domain protein
K08M3_20060	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K08M3_20070	COG0512	Glutamine amidotransferase of anthranilate synthase
K08M3_20090	COG0135	phosphoribosylanthranilate isomerase activity
K08M3_20090	COG0134	indole-3-glycerol-phosphate synthase activity
K08M3_20110	COG0159	tryptophan synthase activity
K08M3_20120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K08M3_20130	COG0318	PFAM AMP-dependent synthetase and ligase
K08M3_20140	COG1301	dicarboxylic acid transport
K08M3_20180	COG2917	probably involved in intracellular septation
K08M3_20190	COG1607	acyl-coa hydrolase
K08M3_20200	COG2350	Protein conserved in bacteria
K08M3_20220	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K08M3_20230	COG0583	DNA-binding transcription factor activity
K08M3_20260	COG5001	Diguanylate cyclase
K08M3_20270	COG1032	radical SAM domain protein
K08M3_20310	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K08M3_20320	COG0463	Glycosyl transferase, family 2
K08M3_20330	COG0745	RESPONSE REGULATOR receiver
K08M3_20340	COG5002	protein histidine kinase activity
K08M3_20340	COG3850	Histidine kinase
K08M3_20400	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K08M3_20440	COG0577	efflux transmembrane transporter activity
K08M3_20440	COG1136	(ABC) transporter
K08M3_20450	COG1136	(ABC) transporter
K08M3_20450	COG0577	efflux transmembrane transporter activity
K08M3_20460	COG0577	efflux transmembrane transporter activity
K08M3_20460	COG1136	(ABC) transporter
K08M3_20480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K08M3_20530	COG3118	belongs to the thioredoxin family
K08M3_20540	COG4232	protein-disulfide reductase activity
K08M3_20610	COG2863	cytochrome
K08M3_20620	COG3258	Cytochrome c
K08M3_20630	COG2995	paraquat-inducible protein a
K08M3_20640	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K08M3_20640	COG3008	intermembrane lipid transfer
K08M3_20680	COG4166	transmembrane transport
K08M3_20700	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K08M3_20710	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
K08M3_20730	COG0539	negative regulation of cytoplasmic translation
K08M3_20740	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K08M3_20750	COG0616	signal peptide processing
K08M3_20760	COG1028	Short-chain dehydrogenase reductase Sdr
K08M3_20790	COG0587	DNA-directed DNA polymerase activity
K08M3_20800	COG0784	Response regulator, receiver
K08M3_20800	COG0835	chemotaxis
K08M3_20810	COG1940	carbohydrate kinase activity
K08M3_20820	COG0469	pyruvate kinase activity
K08M3_20830	COG4667	esterase of the alpha-beta hydrolase superfamily
K08M3_20860	COG0733	neurotransmitter:sodium symporter activity
K08M3_20890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K08M3_20890	COG1263	PTS System
K08M3_20900	COG0084	hydrolase, TatD family'
K08M3_20910	COG0470	DNA polymerase III
K08M3_20920	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K08M3_20930	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K08M3_20990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K08M3_21000	COG0416	fatty acid biosynthetic process
K08M3_21020	COG1399	metal-binding, possibly nucleic acid-binding protein
K08M3_21030	COG0424	maF-like protein
K08M3_21040	COG0564	pseudouridine synthase activity
K08M3_21050	COG1530	ribonuclease E activity
K08M3_21060	COG0659	secondary active sulfate transmembrane transporter activity
K08M3_21070	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K08M3_21080	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
K08M3_21100	COG0572	uridine kinase
K08M3_21120	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K08M3_21120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K08M3_21160	COG2186	Transcriptional regulator
K08M3_21170	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K08M3_21180	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K08M3_21190	COG3318	Belongs to the UPF0149 family
K08M3_21190	COG3012	SEC-C Motif Domain Protein
K08M3_21200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K08M3_21210	COG3706	GGDEF domain
K08M3_21220	COG0366	Alpha amylase catalytic
K08M3_21230	COG1122	ATPase activity
K08M3_21240	COG4120	Belongs to the binding-protein-dependent transport system permease family
K08M3_21260	COG3092	negative regulation of chromosome organization
K08M3_21270	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K08M3_21280	COG0280	phosphate acetyltransferase
K08M3_21280	COG0857	belongs to the CobB CobQ family
K08M3_21300	COG0435	Glutathione S-transferase
K08M3_21320	COG0444	Belongs to the ABC transporter superfamily
K08M3_21330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K08M3_21340	COG0601	transmembrane transport
K08M3_21360	COG0314	molybdopterin synthase activity
K08M3_21370	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K08M3_21380	COG0315	cyclic pyranopterin monophosphate synthase activity
K08M3_21390	COG0521	Mo-molybdopterin cofactor biosynthetic process
K08M3_21400	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K08M3_21410	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K08M3_21420	COG2198	Histidine kinase
K08M3_21430	COG2204	response regulator
K08M3_21440	COG0556	nucleotide-excision repair
K08M3_21460	COG1882	Formate acetyltransferase
K08M3_21470	COG4657	Part of a membrane complex involved in electron transport
K08M3_21480	COG2878	Part of a membrane complex involved in electron transport
K08M3_21490	COG4656	Part of a membrane complex involved in electron transport
K08M3_21500	COG4658	electron transport chain
K08M3_21510	COG4659	FMN binding
K08M3_21520	COG4660	Part of a membrane complex involved in electron transport
K08M3_21530	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K08M3_21540	COG0346	lactoylglutathione lyase activity
K08M3_21560	COG2885	chlorophyll binding
K08M3_21570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K08M3_21580	COG2056	Na+-H+ antiporter family
K08M3_21620	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K08M3_21660	COG1454	alcohol dehydrogenase
K08M3_21660	COG1012	belongs to the aldehyde dehydrogenase family
K08M3_21670	COG2095	MarC family integral membrane protein
K08M3_21680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K08M3_21690	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K08M3_21700	COG1757	Na H antiporter
K08M3_21730	COG3081	Nucleoid-associated protein
K08M3_21740	COG3082	Protein of unknown function (DUF1414)
K08M3_21750	COG3083	sulfuric ester hydrolase activity
K08M3_21770	COG0123	including yeast histone deacetylase and acetoin utilization protein
K08M3_21800	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K08M3_21810	COG0778	Nitroreductase
K08M3_21830	COG1902	pentaerythritol trinitrate reductase activity
K08M3_21830	COG0446	pyridine nucleotide-disulphide oxidoreductase
K08M3_21840	COG0616	signal peptide processing
K08M3_21850	COG0252	asparaginase activity
K08M3_21860	COG3139	Protein of unknown function (DUF1315)
K08M3_21880	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K08M3_21890	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K08M3_21920	COG2226	methyltransferase
K08M3_21950	COG1785	Belongs to the alkaline phosphatase family
K08M3_21970	COG0346	lactoylglutathione lyase activity
K08M3_21980	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
K08M3_21990	COG0668	transmembrane transport
K08M3_22000	COG2983	Belongs to the UPF0260 family
K08M3_22010	COG2261	transglycosylase associated protein
K08M3_22030	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K08M3_22040	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K08M3_22050	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K08M3_22070	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K08M3_22080	COG2832	Protein of unknown function (DUF454)
K08M3_22100	COG0745	RESPONSE REGULATOR receiver
K08M3_22110	COG0583	DNA-binding transcription factor activity
K08M3_22120	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K08M3_22130	COG1286	toxin biosynthetic process
K08M3_22140	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
K08M3_22150	COG0285	dihydrofolate synthase activity
K08M3_22160	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K08M3_22170	COG0101	tRNA pseudouridine synthase activity
K08M3_22190	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K08M3_22200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K08M3_22210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K08M3_22220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K08M3_22220	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K08M3_22230	COG0431	NADPH-dependent FMN reductase
K08M3_22250	COG3101	peptidyl-lysine hydroxylation
K08M3_22260	COG2860	membrane
K08M3_22270	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K08M3_22280	COG2890	protein-(glutamine-N5) methyltransferase activity
K08M3_22290	COG2840	Smr protein MutS2
K08M3_22300	COG2062	phosphohistidine phosphatase, SixA
K08M3_22330	COG1024	Enoyl-CoA hydratase
K08M3_22330	COG1250	3-hydroxyacyl-CoA dehydrogenase
K08M3_22340	COG0183	Belongs to the thiolase family
K08M3_22390	COG2067	long-chain fatty acid transport protein
K08M3_22430	COG3088	subunit of a heme lyase
K08M3_22430	COG4235	cytochrome complex assembly
K08M3_22450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K08M3_22460	COG1138	Cytochrome C-type biogenesis protein
K08M3_22470	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K08M3_22480	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K08M3_22490	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K08M3_22500	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K08M3_22510	COG4133	protoheme IX ABC transporter activity
K08M3_22530	COG0835	chemotaxis
K08M3_22550	COG1192	Involved in chromosome partitioning
K08M3_22560	COG2201	protein-glutamate methylesterase activity
K08M3_22570	COG2198	Histidine kinase
K08M3_22570	COG0643	Histidine kinase
K08M3_22580	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
K08M3_22610	COG0455	bacterial-type flagellum organization
K08M3_22660	COG1987	bacterial-type flagellum assembly
K08M3_22770	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K08M3_22790	COG1677	Flagellar hook-basal body complex protein FliE
K08M3_22800	COG2204	response regulator
K08M3_22810	COG4191	Histidine kinase
K08M3_22820	COG2204	response regulator
K08M3_22830	COG1516	flagellar protein fliS
K08M3_22850	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K08M3_22860	COG1334	flagellar protein FlaG
K08M3_22870	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K08M3_22880	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K08M3_22890	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K08M3_22900	COG2837	iron assimilation
K08M3_22950	COG1393	Belongs to the ArsC family
K08M3_22960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K08M3_23000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K08M3_23020	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K08M3_23070	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K08M3_23090	COG1053	succinate dehydrogenase
K08M3_23220	COG0210	DNA helicase
K08M3_23260	COG2963	transposase activity
K08M3_23290	COG1278	Cold shock
K08M3_23340	COG1278	Cold shock
K08M3_23350	COG4974	Belongs to the 'phage' integrase family
K08M3_23360	COG0330	HflC and HflK could
K08M3_23400	COG1278	Cold shock
K08M3_23430	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K08M3_23460	COG4783	chaperone-mediated protein folding
K08M3_23470	COG1393	Belongs to the ArsC family
K08M3_23510	COG2233	PERMEase
K08M3_23520	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K08M3_23530	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K08M3_23540	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K08M3_23560	COG0121	glutamine amidotransferase
K08M3_23570	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K08M3_23580	COG1960	acyl-CoA dehydrogenase activity
K08M3_23640	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K08M3_23650	COG0328	RNA-DNA hybrid ribonuclease activity
K08M3_23660	COG2226	methyltransferase
K08M3_23670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K08M3_23680	COG1388	LysM domain
K08M3_23680	COG0741	lytic transglycosylase activity
K08M3_23700	COG3021	interspecies interaction between organisms
K08M3_23710	COG0347	Belongs to the P(II) protein family
K08M3_23740	COG0825	malonyl-CoA metabolic process
K08M3_23750	COG0587	DNA-directed DNA polymerase activity
K08M3_23770	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K08M3_23780	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K08M3_23800	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K08M3_23810	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
K08M3_23830	COG0750	zinc metalloprotease
K08M3_23840	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K08M3_23850	COG0575	Belongs to the CDS family
K08M3_23860	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K08M3_23870	COG0233	cytoplasmic translational termination
K08M3_23880	COG0528	UMP kinase activity
K08M3_23890	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K08M3_23900	COG0052	Belongs to the universal ribosomal protein uS2 family
K08M3_23910	COG0024	Methionine aminopeptidase
K08M3_23920	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K08M3_23940	COG0564	pseudouridine synthase activity
K08M3_23950	COG3098	single-species biofilm formation
K08M3_24010	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K08M3_24020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K08M3_24070	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K08M3_24080	COG0254	rRNA binding
K08M3_24090	COG1720	tRNA m6t6A37 methyltransferase activity
K08M3_24100	COG0442	prolyl-tRNA aminoacylation
K08M3_24140	COG0733	neurotransmitter:sodium symporter activity
K08M3_24170	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K08M3_24180	COG0514	ATP-dependent DNA helicase (RecQ)
K08M3_24230	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K08M3_24390	COG0659	secondary active sulfate transmembrane transporter activity
K08M3_24400	COG0589	response to stress
K08M3_24410	COG0519	Catalyzes the synthesis of GMP from XMP
K08M3_24510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K08M3_24530	COG3706	GGDEF domain
K08M3_24530	COG0745	RESPONSE REGULATOR receiver
K08M3_24550	COG1477	protein flavinylation
K08M3_24560	COG2871	sodium ion transport
K08M3_24570	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K08M3_24580	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K08M3_24590	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K08M3_24600	COG1805	sodium ion transport
K08M3_24610	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K08M3_24620	COG0271	Belongs to the BolA IbaG family
K08M3_24630	COG2813	Specifically methylates the guanine in position
K08M3_24640	COG3056	Lipoprotein
K08M3_24680	COG1595	DNA-templated transcription, initiation
K08M3_24720	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K08M3_24730	COG0693	protein deglycase activity
K08M3_24740	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K08M3_24750	COG3706	GGDEF domain
K08M3_24760	COG2166	iron-sulfur cluster assembly
K08M3_24770	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K08M3_24780	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
K08M3_24800	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K08M3_24800	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K08M3_24820	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K08M3_24830	COG1074	ATP-dependent DNA helicase activity
K08M3_24840	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K08M3_24940	COG0270	DNA (cytosine-5-)-methyltransferase activity
K08M3_24990	COG3141	response to X-ray
K08M3_25020	COG2171	N-acyltransferase activity
K08M3_25030	COG0584	glycerophosphoryl diester phosphodiesterase
K08M3_25040	COG2271	Major facilitator Superfamily
K08M3_25050	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K08M3_25060	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K08M3_25070	COG1349	DNA-binding transcription factor activity
K08M3_25080	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K08M3_25090	COG0598	Magnesium transport protein CorA
K08M3_25130	COG1609	Transcriptional regulator
K08M3_25140	COG0583	DNA-binding transcription factor activity
K08M3_25220	COG1022	Amp-dependent synthetase and ligase
K08M3_25240	COG0583	DNA-binding transcription factor activity
K08M3_25250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K08M3_25260	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K08M3_25280	COG0560	Phosphoserine phosphatase
K08M3_25300	COG0813	purine-nucleoside phosphorylase activity
K08M3_25310	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K08M3_25320	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K08M3_25330	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K08M3_25340	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K08M3_25350	COG0084	hydrolase, TatD family'
K08M3_25410	COG3153	acetyltransferase
K08M3_25460	COG0534	Mate efflux family protein
K08M3_25490	COG1185	polyribonucleotide nucleotidyltransferase activity
K08M3_25500	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K08M3_25510	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K08M3_25520	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K08M3_25530	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K08M3_25540	COG0195	Participates in both transcription termination and antitermination
K08M3_25550	COG0779	Required for maturation of 30S ribosomal subunits
K08M3_25580	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K08M3_25590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K08M3_25600	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K08M3_25610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K08M3_25620	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K08M3_25630	COG1534	Rna-binding protein
K08M3_25640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K08M3_25650	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K08M3_25660	COG2027	D-alanyl-D-alanine carboxypeptidase
K08M3_25680	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K08M3_25690	COG0739	heme binding
K08M3_25740	COG0628	permease
K08M3_25770	COG0747	negative chemotaxis
K08M3_25790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K08M3_25800	COG0444	Belongs to the ABC transporter superfamily
K08M3_25810	COG4608	Belongs to the ABC transporter superfamily
K08M3_25830	COG2971	BadF BadG BcrA BcrD
K08M3_25860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K08M3_25870	COG3842	ATPase activity
K08M3_25890	COG1840	ABC-type Fe3 transport system, periplasmic component
K08M3_25900	COG0004	ammonium transporteR
K08M3_25920	COG3112	Uncharacterised protein family (UPF0231)
K08M3_25930	COG1049	propionate catabolic process, 2-methylcitrate cycle
K08M3_25940	COG1752	Esterase of the alpha-beta hydrolase superfamily
K08M3_25950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K08M3_25960	COG1643	Atp-dependent helicase
K08M3_25970	COG1489	DNA binding
K08M3_25980	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K08M3_25990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K08M3_26010	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K08M3_26020	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K08M3_26030	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K08M3_26040	COG1560	Kdo2-lipid A biosynthetic process
K08M3_26050	COG0842	Transport permease protein
K08M3_26060	COG1131	(ABC) transporter
K08M3_26070	COG0659	secondary active sulfate transmembrane transporter activity
K08M3_26080	COG0288	reversible hydration of carbon dioxide
K08M3_26110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K08M3_26120	COG0508	dehydrogenase complex catalyzes the overall conversion of
K08M3_26130	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K08M3_26140	COG2186	Transcriptional regulator
K08M3_26160	COG0157	Belongs to the NadC ModD family
K08M3_26170	COG4969	Belongs to the N-Me-Phe pilin family
K08M3_26180	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K08M3_26190	COG1459	type II secretion system
K08M3_26210	COG0237	dephospho-CoA kinase activity
K08M3_26220	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
K08M3_26230	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K08M3_26260	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K08M3_26270	COG0228	four-way junction DNA binding
K08M3_26280	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K08M3_26290	COG4137	Cytochrome C assembly protein
K08M3_26300	COG4536	flavin adenine dinucleotide binding
K08M3_26310	COG1854	S-ribosylhomocysteine lyase activity
K08M3_26340	COG0612	Peptidase, M16
K08M3_26350	COG1238	metal cluster binding
K08M3_26370	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K08M3_26380	COG5016	pyruvate
K08M3_26380	COG0511	ligase activity, forming carbon-carbon bonds
K08M3_26510	COG0527	aspartate kinase activity
K08M3_26520	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K08M3_26530	COG2137	regulation of response to DNA damage stimulus
K08M3_26540	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K08M3_26550	COG1546	Belongs to the CinA family
K08M3_26560	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K08M3_26570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K08M3_26590	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K08M3_26600	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K08M3_26620	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K08M3_26630	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K08M3_26640	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K08M3_26650	COG0148	phosphopyruvate hydratase activity
K08M3_26660	COG0504	CTP synthase activity
K08M3_26670	COG3956	TIGRFAM MazG family protein
K08M3_26690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K08M3_26700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K08M3_26720	COG0736	holo-[acyl-carrier-protein] synthase activity
K08M3_26730	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K08M3_26740	COG1381	Involved in DNA repair and RecF pathway recombination
K08M3_26750	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K08M3_26770	COG0681	Belongs to the peptidase S26 family
K08M3_26780	COG0481	GTPase activity
K08M3_26790	COG3086	response to oxidative stress
K08M3_26820	COG1595	DNA-templated transcription, initiation
K08M3_26830	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K08M3_26850	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K08M3_26890	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K08M3_26900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K08M3_26910	COG3079	Belongs to the UPF0149 family
K08M3_26920	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K08M3_26930	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K08M3_26940	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K08M3_26950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K08M3_26970	COG0583	DNA-binding transcription factor activity
K08M3_27000	COG0668	transmembrane transport
K08M3_27010	COG0191	fructose-bisphosphate aldolase activity
K08M3_27040	COG4771	TonB-dependent receptor
K08M3_27050	COG0583	DNA-binding transcription factor activity
K08M3_27060	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K08M3_27070	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K08M3_27090	COG3091	SprT-like family
K08M3_27100	COG2356	endonuclease I
K08M3_27110	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K08M3_27120	COG0189	ligase activity
K08M3_27130	COG1678	Uncharacterized ACR, COG1678
K08M3_27140	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K08M3_27170	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K08M3_27180	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K08M3_27190	COG0762	integral membrane protein
K08M3_27200	COG1872	DUF167
K08M3_27220	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K08M3_27230	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K08M3_27240	COG2066	Belongs to the glutaminase family
K08M3_27260	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K08M3_27280	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
K08M3_27370	COG0840	transmembrane signaling receptor activity
K08M3_27520	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K08M3_27540	COG3394	polysaccharide catabolic process
K08M3_27550	COG1486	melibiose metabolic process
K08M3_27560	COG1447	Phosphotransferase system cellobiose-specific component IIA
K08M3_27570	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K08M3_27590	COG0726	polysaccharide deacetylase
K08M3_27610	COG1028	Short-chain dehydrogenase reductase Sdr
K08M3_27620	COG4325	translation initiation factor activity
K08M3_27640	COG0795	lipopolysaccharide-transporting ATPase activity
K08M3_27650	COG0795	lipopolysaccharide-transporting ATPase activity
K08M3_27660	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K08M3_27670	COG2927	DNA polymerase III (CHI subunit)
K08M3_27680	COG0525	valine-tRNA ligase activity
K08M3_27700	COG0456	acetyltransferase
K08M3_27760	COG0540	Belongs to the ATCase OTCase family
K08M3_27770	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K08M3_27780	COG0251	oxidation-reduction process
K08M3_27790	COG0204	Acyl-transferase
K08M3_27800	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K08M3_27810	COG5007	Belongs to the BolA IbaG family
K08M3_27830	COG2854	intermembrane phospholipid transfer
K08M3_27840	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K08M3_27850	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K08M3_27860	COG1127	ABC transporter
K08M3_27880	COG0517	IMP dehydrogenase activity
K08M3_27880	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K08M3_27900	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K08M3_27910	COG1137	ATPase activity
K08M3_27930	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K08M3_27940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K08M3_27950	COG1660	Displays ATPase and GTPase activities
K08M3_27960	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K08M3_27970	COG2239	Acts as a magnesium transporter
K08M3_27980	COG0312	modulator of DNA gyrase
K08M3_27990	COG3028	Belongs to the UPF0307 family
K08M3_28000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K08M3_28010	COG0564	pseudouridine synthase activity
K08M3_28030	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K08M3_28040	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K08M3_28050	COG0312	modulator of DNA gyrase
K08M3_28060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K08M3_28070	COG3164	Protein of unknown function
K08M3_28080	COG1530	ribonuclease E activity
K08M3_28090	COG0424	maF-like protein
K08M3_28100	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K08M3_28110	COG1792	Involved in formation and maintenance of cell shape
K08M3_28120	COG1077	Cell shape determining protein MreB Mrl
K08M3_28210	COG1459	type II secretion system
K08M3_28220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K08M3_28240	COG3409	Peptidoglycan-binding domain 1 protein
K08M3_28240	COG3267	Type II secretory pathway component ExeA
K08M3_28250	COG1450	Type ii and iii secretion system protein
K08M3_28290	COG2200	EAL domain
K08M3_28290	COG2199	diguanylate cyclase activity
K08M3_28300	COG0629	single-stranded DNA binding
K08M3_28330	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K08M3_28370	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K08M3_28380	COG0527	aspartate kinase activity
K08M3_28390	COG0646	methionine synthase
K08M3_28390	COG1410	methionine synthase
K08M3_28520	COG0175	sulfate reduction
K08M3_28530	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K08M3_28540	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K08M3_28580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K08M3_28590	COG0735	belongs to the Fur family
K08M3_28610	COG0166	Belongs to the GPI family
K08M3_28620	COG0432	Pfam Uncharacterised protein family UPF0047
K08M3_28630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K08M3_28640	COG0305	Participates in initiation and elongation during chromosome replication
K08M3_28680	COG2965	DNA replication, synthesis of RNA primer
K08M3_28690	COG0360	Binds together with S18 to 16S ribosomal RNA
K08M3_28700	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K08M3_28710	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K08M3_28730	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K08M3_28740	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K08M3_28800	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K08M3_28820	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K08M3_28820	COG0678	peroxiredoxin activity
K08M3_28830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K08M3_28860	COG0165	Argininosuccinate lyase
K08M3_28860	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K08M3_28870	COG0137	argininosuccinate synthase activity
K08M3_28890	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K08M3_28910	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K08M3_28930	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K08M3_28940	COG0527	aspartate kinase activity
K08M3_28940	COG0460	homoserine dehydrogenase
K08M3_28950	COG0626	cystathionine gamma-synthase activity
K08M3_28970	COG0281	malic enzyme
K08M3_28990	COG2906	2 iron, 2 sulfur cluster binding
K08M3_29000	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K08M3_29010	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K08M3_29050	COG2923	Belongs to the DsrF TusC family
K08M3_29060	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
K08M3_29070	COG2964	Protein conserved in bacteria
K08M3_29080	COG0545	Peptidyl-prolyl cis-trans isomerase
K08M3_29110	COG1446	asparaginase
K08M3_29120	COG1047	Peptidyl-prolyl cis-trans
K08M3_29150	COG2249	NAD(P)H dehydrogenase (quinone) activity
K08M3_29160	COG0488	(ABC) transporter
K08M3_29180	COG0429	hydrolase of the alpha beta-hydrolase fold
K08M3_29200	COG3954	Phosphoribulokinase
K08M3_29210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K08M3_29250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K08M3_29260	COG0512	Glutamine amidotransferase of anthranilate synthase
K08M3_29290	COG0180	Tryptophanyl-tRNA synthetase
K08M3_29300	COG0546	phosphoglycolate phosphatase activity
K08M3_29310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K08M3_29320	COG0557	exoribonuclease II activity
K08M3_29330	COG1959	2 iron, 2 sulfur cluster binding
K08M3_29340	COG1017	nitric oxide dioxygenase activity
K08M3_29340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K08M3_29350	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
K08M3_29360	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K08M3_29370	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
K08M3_29380	COG0330	HflC and HflK could
K08M3_29390	COG0330	HflC and HflK could
K08M3_29400	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K08M3_29420	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K08M3_29430	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K08M3_29450	COG0802	atpase or kinase
K08M3_29470	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K08M3_29600	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K08M3_29610	COG1162	GTPase activity
K08M3_29620	COG0688	phosphatidylethanolamine metabolic process
K08M3_29630	COG0471	metal ion transport
K08M3_29650	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K08M3_29660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K08M3_29670	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K08M3_29680	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K08M3_29690	COG1045	serine acetyltransferase
K08M3_29700	COG4942	peptidase
K08M3_29740	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K08M3_29750	COG1053	succinate dehydrogenase
K08M3_29760	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K08M3_29770	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K08M3_29780	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K08M3_29810	COG1509	lysine 2,3-aminomutase activity
K08M3_29820	COG1285	pathogenesis
K08M3_29840	COG0459	protein refolding
K08M3_29850	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K08M3_29860	COG0534	Mate efflux family protein
K08M3_29870	COG0205	6-phosphofructokinase activity
K08M3_29880	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K08M3_29890	COG3678	ATP-independent chaperone mediated protein folding
K08M3_29900	COG0745	RESPONSE REGULATOR receiver
K08M3_29910	COG2205	protein histidine kinase activity
K08M3_29930	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K08M3_29940	COG3030	protein affecting phage T7 exclusion by the F plasmid
K08M3_29950	COG1027	Aspartate ammonia-lyase
K08M3_29960	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K08M3_29970	COG4232	protein-disulfide reductase activity
K08M3_29990	COG3263	regulation of cellular component size
K08M3_30010	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K08M3_30060	COG2814	Major facilitator Superfamily
K08M3_30090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K08M3_30100	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K08M3_30110	COG0511	ligase activity, forming carbon-carbon bonds
K08M3_30120	COG0439	Biotin carboxylase
K08M3_30130	COG2264	protein methyltransferase activity
K08M3_30140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K08M3_30150	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K08M3_30170	COG0488	(ABC) transporter
K08M3_30270	COG1982	Orn Lys Arg decarboxylase major
K08M3_30280	COG0531	amino acid
K08M3_30290	COG3710	Transcriptional regulator
K08M3_30300	COG0789	Transcriptional regulator
K08M3_30320	COG0151	Belongs to the GarS family
K08M3_30350	COG1253	flavin adenine dinucleotide binding
K08M3_30360	COG3068	Protein conserved in bacteria
K08M3_30380	COG1573	uracil-dna glycosylase
K08M3_30390	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K08M3_30400	COG2816	NAD+ diphosphatase activity
K08M3_30410	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
K08M3_30420	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K08M3_30430	COG0085	RNA polymerase activity
K08M3_30440	COG0222	ribosome binding
K08M3_30450	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K08M3_30480	COG0250	Participates in transcription elongation, termination and antitermination
K08M3_30490	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K08M3_30500	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K08M3_30560	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K08M3_30560	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K08M3_30570	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K08M3_30590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K08M3_30760	COG4206	TonB-dependent receptor
K08M3_30800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K08M3_30810	COG0534	Mate efflux family protein
K08M3_30820	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K08M3_30830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K08M3_30840	COG2937	Belongs to the GPAT DAPAT family
K08M3_30850	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K08M3_30860	COG3161	chorismate lyase activity
K08M3_30870	COG1580	Controls the rotational direction of flagella during chemotaxis
K08M3_30880	COG0705	Rhomboid family
K08M3_30890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K08M3_30910	COG2177	Part of the ABC transporter FtsEX involved in
K08M3_30920	COG2884	Cell division ATP-binding protein ftsE
K08M3_30930	COG0552	protein localization to endoplasmic reticulum
K08M3_30940	COG0742	ribosomal rna small subunit methyltransferase
K08M3_30960	COG2095	MarC family integral membrane protein
K08M3_31040	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K08M3_31050	COG0640	Transcriptional regulator
K08M3_31060	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K08M3_31070	COG1280	lysine exporter protein (LysE YggA)
K08M3_31080	COG2267	carboxylic ester hydrolase activity
K08M3_31090	COG0561	phosphatase activity
K08M3_31130	COG3287	FIST C domain
K08M3_31130	COG2200	EAL domain
K08M3_31130	COG2199	diguanylate cyclase activity
K08M3_31140	COG1011	Hydrolase
K08M3_31150	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K08M3_31180	COG0019	diaminopimelate decarboxylase activity
K08M3_31190	COG1965	Belongs to the frataxin family
K08M3_31200	COG3072	Adenylate cyclase
K08M3_31210	COG0181	hydroxymethylbilane synthase activity
K08M3_31220	COG1587	Uroporphyrinogen-III synthase
K08M3_31230	COG2959	enzyme of heme biosynthesis
K08M3_31240	COG3071	HemY protein
K08M3_31330	COG0633	Ferredoxin
K08M3_31340	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K08M3_31360	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K08M3_31370	COG3118	belongs to the thioredoxin family
K08M3_31380	COG0513	Belongs to the DEAD box helicase family
K08M3_31390	COG0248	Ppx GppA phosphatase
K08M3_31410	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K08M3_31430	COG0514	ATP-dependent DNA helicase (RecQ)
K08M3_31440	COG2962	Rard protein
K08M3_31460	COG1280	lysine exporter protein (LysE YggA)
K08M3_31470	COG0405	Gamma-glutamyltransferase
K08M3_31480	COG0210	DNA helicase
K08M3_31500	COG3220	belongs to the UPF0276 family
K08M3_31560	COG0006	proline dipeptidase activity
K08M3_31560	COG0006	proline dipeptidase activity
K08M3_31590	COG2104	thiamine diphosphate biosynthetic process
K08M3_31600	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K08M3_31640	COG2132	Multicopper oxidase
K08M3_31740	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K08M3_31780	COG0009	L-threonylcarbamoyladenylate synthase
K08M3_31790	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K08M3_31800	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K08M3_31810	COG0551	DNA topoisomerase type I activity
K08M3_31820	COG2922	Belongs to the Smg family
K08M3_31830	COG0758	DNA mediated transformation
K08M3_31850	COG0242	peptide deformylase activity
K08M3_31860	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K08M3_31870	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K08M3_31870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K08M3_31880	COG0569	domain protein
K08M3_31890	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K08M3_31910	COG1272	protein, Hemolysin III
K08M3_31920	COG4326	sporulation control protein
K08M3_31940	COG3084	Protein conserved in bacteria
K08M3_31960	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K08M3_31970	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K08M3_31980	COG0204	Acyl-transferase
K08M3_32000	COG0606	chelatase, subunit chli
K08M3_32020	COG3978	acetolactate synthase activity
K08M3_32030	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K08M3_32040	COG0129	dihydroxy-acid dehydratase activity
K08M3_32060	COG0583	DNA-binding transcription factor activity
K08M3_32070	COG2814	Major facilitator Superfamily
K08M3_32090	COG0765	amino acid transport
K08M3_32120	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K08M3_32130	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K08M3_32140	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K08M3_32150	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K08M3_32160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K08M3_32170	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K08M3_32190	COG0356	it plays a direct role in the translocation of protons across the membrane
K08M3_32200	COG3312	ion transport
K08M3_32210	COG1475	DNA binding
K08M3_32220	COG1192	Involved in chromosome partitioning
K08M3_32230	COG0357	Ribosomal RNA small subunit methyltransferase G
K08M3_32240	COG0445	tRNA wobble uridine modification
K08M3_32250	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K08M3_32270	COG0706	membrane insertase activity
K08M3_32280	COG0594	ribonuclease P activity
K08M3_32300	COG1126	abc transporter atp-binding protein
K08M3_32350	COG1444	tRNA N-acetyltransferase activity
K08M3_32390	COG3340	Belongs to the peptidase S51 family
K08M3_32400	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K08M3_32410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K08M3_32410	COG1263	PTS System
K08M3_32420	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K08M3_32450	COG4166	transmembrane transport
K08M3_32550	COG0259	pyridoxamine-phosphate oxidase activity
K08M3_32600	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K08M3_32680	COG1132	(ABC) transporter
K08M3_32700	COG0513	Belongs to the DEAD box helicase family
K08M3_32710	COG2258	MOSC domain
K08M3_32800	COG3634	alkyl hydroperoxide reductase activity
K08M3_32810	COG0450	alkyl hydroperoxide reductase
K08M3_32890	COG1846	Transcriptional regulator
K08M3_32900	COG1764	response to oxidative stress
K08M3_32980	COG1136	(ABC) transporter
K08M3_33040	COG0745	RESPONSE REGULATOR receiver
K08M3_33060	COG1653	transport
K08M3_33070	COG0019	diaminopimelate decarboxylase activity
K08M3_33080	COG4264	IucA IucC family
K08M3_33130	COG4772	TonB-dependent receptor
K08M3_33140	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K08M3_33150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K08M3_33160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K08M3_33170	COG1120	ATPase activity
K08M3_33180	COG0840	transmembrane signaling receptor activity
K08M3_33190	COG0612	Peptidase, M16
K08M3_33210	COG0739	heme binding
K08M3_33240	COG2814	Major facilitator Superfamily
K08M3_33260	COG1609	Transcriptional regulator
K08M3_33270	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K08M3_33320	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K08M3_33330	COG1609	Transcriptional regulator
K08M3_33380	COG0596	Alpha beta hydrolase
K08M3_33430	COG1760	l-serine dehydratase
K08M3_33450	COG4580	involved in the transport of maltose and maltodextrins
K08M3_33490	COG2356	endonuclease I
K08M3_33530	COG1982	Orn Lys Arg decarboxylase major
K08M3_33540	COG0531	amino acid
K08M3_33560	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K08M3_33570	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
K08M3_33580	COG1162	GTPase activity
K08M3_33590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K08M3_33590	COG1263	PTS System
K08M3_33600	COG1999	signal sequence binding
K08M3_33630	COG2909	trisaccharide binding
K08M3_33640	COG0058	SHG alpha-glucan phosphorylase activity
K08M3_33650	COG1640	4-alpha-glucanotransferase
K08M3_33660	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K08M3_33670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K08M3_33680	COG0366	Alpha amylase catalytic
K08M3_33700	COG3366	ferrous iron transmembrane transporter activity
K08M3_33710	COG0700	Nucleoside recognition
K08M3_33720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K08M3_33730	COG3339	Conserved Protein
K08M3_33740	COG1301	dicarboxylic acid transport
K08M3_33760	COG0583	DNA-binding transcription factor activity
K08M3_33810	COG1596	polysaccharide export
K08M3_33840	COG2095	MarC family integral membrane protein
K08M3_33850	COG4667	esterase of the alpha-beta hydrolase superfamily
K08M3_33860	COG3397	chitin binding
K08M3_33870	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K08M3_33880	COG0415	Belongs to the DNA photolyase family
K08M3_33920	COG1686	Belongs to the peptidase S11 family
K08M3_33970	COG0583	DNA-binding transcription factor activity
K08M3_33980	COG4628	conserved protein (DUF2132)
K08M3_34030	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K08M3_34040	COG0628	permease
K08M3_34090	COG1289	transmembrane transporter activity
K08M3_34120	COG2814	Major facilitator Superfamily
K08M3_34140	COG0454	-acetyltransferase
K08M3_34160	COG0745	RESPONSE REGULATOR receiver
K08M3_34170	COG2205	protein histidine kinase activity
K08M3_34200	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K08M3_34210	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K08M3_34290	COG1360	Flagellar Motor Protein
K08M3_34300	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K08M3_34310	COG1191	sigma factor activity
K08M3_34320	COG1580	Controls the rotational direction of flagella during chemotaxis
K08M3_34350	COG1516	flagellar protein fliS
K08M3_34360	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K08M3_34380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K08M3_34410	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K08M3_34430	COG1987	bacterial-type flagellum assembly
K08M3_34480	COG2204	response regulator
K08M3_34510	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K08M3_34620	COG0346	lactoylglutathione lyase activity
K08M3_34670	COG0745	RESPONSE REGULATOR receiver
K08M3_34720	COG3300	MHYT domain
K08M3_34720	COG5001	Diguanylate cyclase
K08M3_34730	COG0156	8-amino-7-oxononanoate synthase activity
K08M3_34740	COG1063	alcohol dehydrogenase
K08M3_34810	COG0668	transmembrane transport
K08M3_34830	COG1304	FMN binding
K08M3_34840	COG1620	l-lactate permease
K08M3_34850	COG0583	DNA-binding transcription factor activity
K08M3_34860	COG1505	serine-type exopeptidase activity
K08M3_34870	COG4172	Belongs to the ABC transporter superfamily
K08M3_34890	COG1067	ATP-dependent peptidase activity
K08M3_34910	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K08M3_34950	COG1247	-acetyltransferase
K08M3_34960	COG0437	4 iron, 4 sulfur cluster binding
K08M3_34970	COG0348	domain, Protein
K08M3_35010	COG1122	ATPase activity
K08M3_35020	COG4720	Psort location CytoplasmicMembrane, score
K08M3_35030	COG1566	PFAM secretion protein HlyD family protein
K08M3_35050	COG3706	GGDEF domain
K08M3_35080	COG0813	purine-nucleoside phosphorylase activity
K08M3_35090	COG3272	Protein of unknown function (DUF1722)
K08M3_35100	COG0789	Transcriptional regulator
K08M3_35110	COG0415	Belongs to the DNA photolyase family
K08M3_35120	COG1376	ErfK ybiS ycfS ynhG family protein
K08M3_35120	COG1388	LysM domain
K08M3_35140	COG0513	Belongs to the DEAD box helicase family
K08M3_35150	COG1770	oligopeptidase
K08M3_35160	COG4771	TonB-dependent receptor
K08M3_35210	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K08M3_35220	COG0573	inorganic phosphate transmembrane transporter activity
K08M3_35230	COG0581	inorganic phosphate transmembrane transporter activity
K08M3_35240	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K08M3_35270	COG2304	oxidoreductase activity
K08M3_35310	COG0714	Associated with various cellular activities
K08M3_35340	COG2197	response regulator
K08M3_35410	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K08M3_35420	COG1120	ATPase activity
K08M3_35430	COG4774	siderophore transport
K08M3_35440	COG1132	(ABC) transporter
K08M3_35470	COG0569	domain protein
K08M3_35480	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K08M3_35490	COG0583	DNA-binding transcription factor activity
K08M3_35530	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K08M3_35540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K08M3_35560	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
K08M3_35570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K08M3_35630	COG2084	Dehydrogenase
K08M3_35640	COG0753	catalase activity
K08M3_35660	COG2130	NADP-dependent
K08M3_35670	COG1309	transcriptional regulator
K08M3_35760	COG3206	protein involved in exopolysaccharide biosynthesis
K08M3_35760	COG0489	protein tyrosine kinase activity
K08M3_35790	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K08M3_35800	COG3842	ATPase activity
K08M3_35820	COG1175	transmembrane transport
K08M3_35830	COG3833	ABC-type maltose transport systems, permease component
K08M3_35890	COG2354	Protein conserved in bacteria
K08M3_35900	COG0418	dihydroorotase activity
K08M3_35910	COG0401	homolog of Blt101
K08M3_35920	COG3217	Mosc domain protein beta barrel domain protein
K08M3_35920	COG0633	Ferredoxin
K08M3_35920	COG0633	Ferredoxin
K08M3_35920	COG3217	Mosc domain protein beta barrel domain protein
K08M3_35940	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K08M3_36020	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K08M3_36030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K08M3_36050	COG0848	biopolymer transport protein
K08M3_36060	COG0811	peptide transport
K08M3_36070	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K08M3_36090	COG3721	Heme iron utilization protein
K08M3_36100	COG0748	coenzyme F420 binding
K08M3_36120	COG0784	Response regulator, receiver
K08M3_36120	COG0835	chemotaxis
K08M3_36130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K08M3_36140	COG0534	Mate efflux family protein
K08M3_36150	COG0444	Belongs to the ABC transporter superfamily
K08M3_36160	COG4608	Belongs to the ABC transporter superfamily
K08M3_36170	COG0747	negative chemotaxis
K08M3_36190	COG1349	DNA-binding transcription factor activity
K08M3_36200	COG2084	Dehydrogenase
K08M3_36210	COG3395	kinase activity
K08M3_36220	COG0235	Class ii aldolase
K08M3_36230	COG3622	Belongs to the hyi family
K08M3_36240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K08M3_36250	COG2610	gluconate transmembrane transporter activity
K08M3_36290	COG0583	DNA-binding transcription factor activity
K08M3_36300	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K08M3_36320	COG4934	collagen metabolic process
K08M3_36340	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K08M3_36350	COG0789	Transcriptional regulator
K08M3_36360	COG0366	Alpha amylase catalytic
K08M3_36400	COG2249	NAD(P)H dehydrogenase (quinone) activity
K08M3_36410	COG0589	response to stress
K08M3_36420	COG0488	(ABC) transporter
K08M3_36430	COG1505	serine-type exopeptidase activity
K08M3_36450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K08M3_36470	COG2067	long-chain fatty acid transport protein
K08M3_36490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K08M3_36540	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K08M3_36580	COG3383	formate dehydrogenase (NAD+) activity
K08M3_36600	COG0842	Transport permease protein
K08M3_36610	COG1131	(ABC) transporter
K08M3_36650	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
K08M3_36670	COG4145	pantothenate transmembrane transporter activity
K08M3_36680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K08M3_36690	COG0800	Aldolase
K08M3_36710	COG2706	6-phosphogluconolactonase activity
K08M3_36720	COG0251	oxidation-reduction process
K08M3_36740	COG1881	PFAM PEBP family protein
K08M3_36760	COG0798	PFAM Bile acid sodium symporter
K08M3_36790	COG1733	regulation of RNA biosynthetic process
K08M3_36850	COG4989	oxidoreductase activity
K08M3_36900	COG0814	amino acid
K08M3_36970	COG0739	heme binding
K08M3_36980	COG5001	Diguanylate cyclase
K08M3_36990	COG0583	DNA-binding transcription factor activity
K08M3_37000	COG2814	Major facilitator Superfamily
K08M3_37040	COG0697	spore germination
K08M3_37050	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K08M3_37070	COG0179	Fumarylacetoacetate (FAA) hydrolase
K08M3_37110	COG1280	lysine exporter protein (LysE YggA)
K08M3_37130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K08M3_37140	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K08M3_37160	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K08M3_37170	COG1845	cytochrome c oxidase, subunit III
K08M3_37200	COG1612	heme a metabolic process
K08M3_37210	COG0109	protoheme IX farnesyltransferase activity
K08M3_37220	COG0545	Peptidyl-prolyl cis-trans isomerase
K08M3_37280	COG1278	Cold shock
K08M3_37290	COG3036	rescue of stalled ribosome
K08M3_37300	COG2199	diguanylate cyclase activity
K08M3_37330	COG1132	(ABC) transporter
K08M3_37340	COG1132	(ABC) transporter
K08M3_37350	COG1538	Outer membrane efflux protein
K08M3_37360	COG2205	protein histidine kinase activity
K08M3_37360	COG0784	Response regulator, receiver
K08M3_37410	COG0840	transmembrane signaling receptor activity
K08M3_37430	COG0783	Belongs to the Dps family
K08M3_37450	COG2133	pyrroloquinoline quinone binding
K08M3_37460	COG1454	alcohol dehydrogenase
K08M3_37470	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
K08M3_37520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K08M3_37530	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K08M3_37540	COG3186	Phenylalanine-4-hydroxylase
K08M3_37590	COG3530	Putative quorum-sensing-regulated virulence factor
K08M3_37630	COG0513	Belongs to the DEAD box helicase family
K08M3_37640	COG4628	conserved protein (DUF2132)
K08M3_37660	COG0133	tryptophan synthase activity
K08M3_37670	COG1278	Cold shock
K08M3_37690	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
K08M3_37710	COG0523	cobalamin synthesis protein
K08M3_37720	COG0513	Belongs to the DEAD box helicase family
K08M3_37760	COG2200	EAL domain
K08M3_37770	COG1119	ATPase activity
K08M3_37810	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K08M3_37840	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
K08M3_37850	COG0513	Belongs to the DEAD box helicase family
K08M3_37860	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K08M3_37880	COG1073	alpha beta
K08M3_37890	COG1073	alpha beta
K08M3_37920	COG0730	response to heat
K08M3_37950	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K08M3_37970	COG0523	cobalamin synthesis protein
K08M3_37980	COG2988	succinylglutamate desuccinylase activity
K08M3_37990	COG0739	heme binding
K08M3_38010	COG0523	cobalamin synthesis protein
K08M3_38030	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K08M3_38040	COG2095	MarC family integral membrane protein
K08M3_38090	COG1024	Enoyl-CoA hydratase
K08M3_38100	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K08M3_38110	COG1960	acyl-CoA dehydrogenase activity
K08M3_38130	COG0183	Belongs to the thiolase family
K08M3_38160	COG1024	Enoyl-CoA hydratase
K08M3_38170	COG1024	Enoyl-CoA hydratase
K08M3_38190	COG1028	Short-chain dehydrogenase reductase Sdr
K08M3_38200	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K08M3_38210	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K08M3_38220	COG1845	cytochrome c oxidase, subunit III
K08M3_38230	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K08M3_38240	COG0109	protoheme IX farnesyltransferase activity
K08M3_38250	COG1902	pentaerythritol trinitrate reductase activity
K08M3_38250	COG0446	pyridine nucleotide-disulphide oxidoreductase
K08M3_38280	COG1012	belongs to the aldehyde dehydrogenase family
K08M3_38300	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K08M3_38360	COG1126	abc transporter atp-binding protein
K08M3_38370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K08M3_38380	COG4215	(ABC) transporter
K08M3_38390	COG4160	amino acid transport
K08M3_38530	COG0443	Heat shock 70 kDa protein
K08M3_38540	COG2847	Copper chaperone PCu(A)C
K08M3_38650	COG3706	GGDEF domain
K08M3_38670	COG0814	amino acid
K08M3_38690	COG0243	molybdopterin cofactor binding
K08M3_38730	COG3707	response regulator
K08M3_38740	COG1116	anion transmembrane transporter activity
K08M3_38740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K08M3_38750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K08M3_38760	COG1116	anion transmembrane transporter activity
K08M3_38770	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K08M3_38770	COG2146	nitrite reductase [NAD(P)H] activity
K08M3_38870	COG2815	serine threonine protein kinase
K08M3_38870	COG0515	serine threonine protein kinase
K08M3_38940	COG0631	protein serine/threonine phosphatase activity
K08M3_39050	COG3501	Rhs element vgr protein
K08M3_39080	COG0420	3'-5' exonuclease activity
K08M3_39090	COG0419	ATPase involved in DNA repair
K08M3_39110	COG3040	lipid binding
K08M3_39130	COG1288	antiporter activity
K08M3_39150	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
K08M3_39180	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K08M3_39210	COG0583	DNA-binding transcription factor activity
K08M3_39220	COG0277	FAD linked oxidase domain protein
K08M3_39250	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K08M3_39320	COG2176	DNA-directed DNA polymerase activity
K08M3_39410	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
K08M3_39420	COG1328	CTP reductase activity
K08M3_39870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K08M3_39910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K08M3_39930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K08M3_39940	COG2146	nitrite reductase [NAD(P)H] activity
K08M3_39950	COG2116	formate transmembrane transporter activity
K08M3_39990	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K08M3_40050	COG2814	Major facilitator Superfamily
K08M3_40060	COG3118	belongs to the thioredoxin family
K08M3_40070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K08M3_40120	COG2271	Major facilitator Superfamily
K08M3_40130	COG3851	Histidine kinase
K08M3_40140	COG2197	response regulator
K08M3_40160	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K08M3_40170	COG0583	DNA-binding transcription factor activity
K08M3_40180	COG0243	molybdopterin cofactor binding
K08M3_40210	COG0384	phenazine biosynthesis protein PhzF
K08M3_40220	COG1794	racemase activity, acting on amino acids and derivatives
K08M3_40280	COG1328	CTP reductase activity
K08M3_40290	COG0602	queuosine metabolic process
K08M3_40300	COG0534	Mate efflux family protein
K08M3_40310	COG2207	Transcriptional regulator
K08M3_40330	COG0189	ligase activity
K08M3_40330	COG4067	protein conserved in archaea
K08M3_40350	COG3111	PFAM Bacterial OB fold (BOF) protein
K08M3_40370	COG0725	ABC transporter, periplasmic molybdate-binding protein
K08M3_40380	COG4149	molybdate abc transporter
K08M3_40390	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K08M3_40410	COG2203	Gaf domain
K08M3_40410	COG3706	GGDEF domain
K08M3_40410	COG4251	negative regulation of phosphorylation
K08M3_40410	COG5001	Diguanylate cyclase
K08M3_40420	COG0745	RESPONSE REGULATOR receiver
K08M3_40420	COG3706	GGDEF domain
K08M3_40450	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K08M3_40460	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K08M3_40510	COG3140	Belongs to the UPF0181 family
K08M3_40540	COG0583	DNA-binding transcription factor activity
K08M3_40840	COG0023	Translation Initiation Factor
K08M3_40860	COG1181	Belongs to the D-alanine--D-alanine ligase family
K08M3_40880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K08M3_40880	COG0045	succinate-CoA ligase (ADP-forming) activity
K08M3_40880	COG1042	CoA-binding domain protein
K08M3_40890	COG0583	DNA-binding transcription factor activity
K08M3_40920	COG5002	protein histidine kinase activity
K08M3_40920	COG5001	Diguanylate cyclase
K08M3_40920	COG3447	MASE1 domain protein
K08M3_40930	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K08M3_40940	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K08M3_40950	COG1984	allophanate hydrolase subunit 2
K08M3_40970	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K08M3_40980	COG4181	ATPase activity
K08M3_41000	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K08M3_41010	COG5001	Diguanylate cyclase
K08M3_41010	COG3300	MHYT domain
K08M3_41080	COG4533	DNA binding
K08M3_41100	COG2050	protein possibly involved in aromatic compounds catabolism
K08M3_41130	COG2067	long-chain fatty acid transport protein
K08M3_41140	COG2267	carboxylic ester hydrolase activity
K08M3_41180	COG0861	Integral membrane protein TerC family
K08M3_41190	COG0737	Belongs to the 5'-nucleotidase family
K08M3_41200	COG3593	DNA synthesis involved in DNA repair
K08M3_41220	COG0583	DNA-binding transcription factor activity
K08M3_41240	COG2116	formate transmembrane transporter activity
K08M3_41250	COG2353	YceI-like domain
K08M3_41260	COG3038	cytochrome b561
K08M3_41300	COG0513	Belongs to the DEAD box helicase family
K08M3_41310	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
K08M3_41330	COG0840	transmembrane signaling receptor activity
K08M3_41340	COG0546	phosphoglycolate phosphatase activity
K08M3_41370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K08M3_41380	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K08M3_41390	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K08M3_41410	COG2207	Transcriptional regulator
K08M3_41420	COG1979	alcohol dehydrogenase
K08M3_41440	COG1126	abc transporter atp-binding protein
K08M3_41450	COG0765	amino acid transport
K08M3_41460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K08M3_41470	COG0765	amino acid transport
K08M3_41480	COG2199	diguanylate cyclase activity
K08M3_41480	COG2200	EAL domain
K08M3_41480	COG2203	Gaf domain
K08M3_41510	COG1609	Transcriptional regulator
K08M3_41520	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K08M3_41520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K08M3_41530	COG1105	Belongs to the carbohydrate kinase PfkB family
K08M3_41540	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
K08M3_41540	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K08M3_41540	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K08M3_41600	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K08M3_41620	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K08M3_41630	COG0509	glycine decarboxylation via glycine cleavage system
K08M3_41650	COG0346	lactoylglutathione lyase activity
K08M3_41660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K08M3_41670	COG0583	DNA-binding transcription factor activity
K08M3_41680	COG0697	spore germination
K08M3_41690	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K08M3_41750	COG2176	DNA-directed DNA polymerase activity
K08M3_41830	COG0242	peptide deformylase activity
K08M3_41890	COG2239	Acts as a magnesium transporter
K08M3_41930	COG0346	lactoylglutathione lyase activity
K08M3_41940	COG1902	pentaerythritol trinitrate reductase activity
K08M3_41960	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K08M3_41960	COG2755	lipolytic protein G-D-S-L family
K08M3_41990	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K08M3_42000	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K08M3_42000	COG0069	glutamate synthase activity
K08M3_42060	COG2076	Multidrug Resistance protein
K08M3_42100	COG2962	Rard protein
K08M3_42130	COG0835	chemotaxis
K08M3_42130	COG0784	Response regulator, receiver
K08M3_42140	COG2197	response regulator
K08M3_42160	COG3706	GGDEF domain
K08M3_42170	COG2197	response regulator
K08M3_42180	COG3300	MHYT domain
K08M3_42180	COG5001	Diguanylate cyclase
K08M3_42190	COG0784	Response regulator, receiver
K08M3_42190	COG2205	protein histidine kinase activity
K08M3_42200	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K08M3_42240	COG0456	acetyltransferase
K08M3_42240	COG1214	PFAM Peptidase M22, glycoprotease
K08M3_42260	COG3069	C4-dicarboxylate transmembrane transporter activity
K08M3_42310	COG3111	PFAM Bacterial OB fold (BOF) protein
K08M3_42320	COG1597	lipid kinase activity
K08M3_42330	COG0583	DNA-binding transcription factor activity
K08M3_42340	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K08M3_42400	COG0714	Associated with various cellular activities
K08M3_42410	COG0641	radical SAM
K08M3_42420	COG3119	arylsulfatase activity
K08M3_42440	COG3119	arylsulfatase activity
K08M3_42450	COG0745	RESPONSE REGULATOR receiver
K08M3_42480	COG2198	Histidine kinase
K08M3_42480	COG2205	protein histidine kinase activity
K08M3_42480	COG0784	Response regulator, receiver
K08M3_42490	COG1879	ABC-type sugar transport system periplasmic component
K08M3_42500	COG1803	Methylglyoxal synthase
K08M3_42510	COG0210	DNA helicase
K08M3_42520	COG1289	transmembrane transporter activity
K08M3_42580	COG1629	transport
K08M3_42580	COG4771	TonB-dependent receptor
K08M3_42600	COG0789	Transcriptional regulator
K08M3_42610	COG4604	ABC transporter, ATP-binding protein
K08M3_42620	COG4605	iron ion homeostasis
K08M3_42630	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K08M3_42640	COG4607	ABC-type enterochelin transport system periplasmic component
K08M3_42660	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
K08M3_42690	COG1609	Transcriptional regulator
K08M3_42700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K08M3_42710	COG1879	ABC-type sugar transport system periplasmic component
K08M3_42720	COG1172	Belongs to the binding-protein-dependent transport system permease family
K08M3_42730	COG1129	ABC transporter
K08M3_42740	COG1869	D-ribose catabolic process
K08M3_42750	COG5001	Diguanylate cyclase
K08M3_42850	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K08M3_42870	COG0784	Response regulator, receiver
K08M3_42870	COG2205	protein histidine kinase activity
K08M3_42900	COG0330	HflC and HflK could
K08M3_42930	COG0517	IMP dehydrogenase activity
K08M3_42930	COG4175	Glycine betaine
K08M3_42940	COG4176	ABC-type proline glycine betaine transport system permease component
K08M3_42970	COG1012	belongs to the aldehyde dehydrogenase family
K08M3_42980	COG1309	transcriptional regulator
K08M3_42990	COG0745	RESPONSE REGULATOR receiver
K08M3_42990	COG3706	GGDEF domain
K08M3_43000	COG1028	Short-chain dehydrogenase reductase Sdr
K08M3_43030	COG1024	Enoyl-CoA hydratase
K08M3_43040	COG1960	acyl-CoA dehydrogenase activity
K08M3_43060	COG0183	Belongs to the thiolase family
K08M3_43080	COG1960	acyl-CoA dehydrogenase activity
K08M3_43090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K08M3_43140	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K08M3_43140	COG3264	Mechanosensitive ion channel
K08M3_43150	COG0110	maltose O-acetyltransferase activity
K08M3_43160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K08M3_43170	COG1271	oxidase subunit
K08M3_43180	COG1294	oxidase, subunit
K08M3_43200	COG0384	phenazine biosynthesis protein PhzF
K08M3_43240	COG3527	Alpha-acetolactate decarboxylase
K08M3_43260	COG1028	Short-chain dehydrogenase reductase Sdr
K08M3_43270	COG0500	methyltransferase
K08M3_43330	COG1022	Amp-dependent synthetase and ligase
K08M3_43380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K08M3_43390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K08M3_43390	COG1263	PTS System
K08M3_43400	COG1486	melibiose metabolic process
K08M3_43410	COG2188	Transcriptional regulator
K08M3_43420	COG1320	monovalent cation:proton antiporter activity
K08M3_43430	COG2212	antiporter activity
K08M3_43460	COG1006	Multisubunit Na H antiporter MnhC subunit
K08M3_43470	COG2111	Na H antiporter
K08M3_43470	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K08M3_43490	COG0589	response to stress
K08M3_43500	COG4221	oxidoreductase activity
K08M3_43510	COG0583	DNA-binding transcription factor activity
K08M3_43530	COG2814	Major facilitator Superfamily
K08M3_43660	COG1522	sequence-specific DNA binding
K08M3_43730	COG0515	serine threonine protein kinase
K08M3_43780	COG3501	Rhs element vgr protein
K08M3_43810	COG2204	response regulator
K08M3_43860	COG0739	heme binding
K08M3_43890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K08M3_43990	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K08M3_44010	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K08M3_44010	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K08M3_44040	COG4989	oxidoreductase activity
K08M3_44070	COG0038	chloride channel
K08M3_44140	COG2897	thiosulfate sulfurtransferase activity
K08M3_44160	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K08M3_44170	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K08M3_44180	COG0840	transmembrane signaling receptor activity
K08M3_44190	COG2814	Major facilitator Superfamily
K08M3_44200	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K08M3_44220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K08M3_44240	COG0840	transmembrane signaling receptor activity
K08M3_44280	COG2195	Cleaves the N-terminal amino acid of tripeptides
K08M3_44310	COG2197	response regulator
K08M3_44320	COG3850	Histidine kinase
K08M3_44330	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K08M3_44350	COG0243	molybdopterin cofactor binding
K08M3_44370	COG3005	denitrification pathway
K08M3_44390	COG3243	poly(R)-hydroxyalkanoic acid synthase
K08M3_44410	COG0183	Belongs to the thiolase family
K08M3_44430	COG1280	lysine exporter protein (LysE YggA)
K08M3_44450	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K08M3_44460	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K08M3_44560	COG1846	Transcriptional regulator
K08M3_44570	COG2205	protein histidine kinase activity
K08M3_44570	COG0784	Response regulator, receiver
K08M3_44580	COG1879	ABC-type sugar transport system periplasmic component
K08M3_44590	COG2827	Endonuclease containing a URI domain
K08M3_44600	COG3132	Protein of unknown function, DUF480
K08M3_44640	COG5002	protein histidine kinase activity
K08M3_44640	COG2205	protein histidine kinase activity
K08M3_44640	COG0784	Response regulator, receiver
K08M3_44700	COG0583	DNA-binding transcription factor activity
K08M3_44720	COG0531	amino acid
K08M3_44750	COG2205	protein histidine kinase activity
K08M3_44760	COG0745	RESPONSE REGULATOR receiver
K08M3_44820	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K08M3_44830	COG2239	Acts as a magnesium transporter
K08M3_44840	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K08M3_44850	COG0402	S-adenosylhomocysteine deaminase activity
K08M3_44860	COG1418	mRNA catabolic process
K08M3_44880	COG2814	Major facilitator Superfamily
K08M3_44900	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K08M3_44940	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K08M3_44970	COG0745	RESPONSE REGULATOR receiver
K08M3_44980	COG2205	protein histidine kinase activity
K08M3_45000	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K08M3_45010	COG2194	sulfuric ester hydrolase activity
K08M3_45050	COG4667	esterase of the alpha-beta hydrolase superfamily
K08M3_45060	COG1741	Belongs to the pirin family
K08M3_45070	COG1278	Cold shock
K08M3_45100	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K08M3_45110	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K08M3_45110	COG0678	peroxiredoxin activity
K08M3_45130	COG1686	Belongs to the peptidase S11 family
K08M3_45150	COG0625	glutathione transferase activity
K08M3_45160	COG1621	beta-fructofuranosidase activity
K08M3_45170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K08M3_45180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K08M3_45180	COG1263	PTS System
K08M3_45220	COG1028	Short-chain dehydrogenase reductase Sdr
K08M3_45250	COG3746	phosphate-selective porin O and P
K08M3_45280	COG0300	oxidoreductase activity
K08M3_45290	COG0583	DNA-binding transcription factor activity
K08M3_45300	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K08M3_45300	COG2207	Transcriptional regulator
K08M3_45310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K08M3_45350	COG0513	Belongs to the DEAD box helicase family
K08M3_45370	COG0583	DNA-binding transcription factor activity
K08M3_45400	COG1902	pentaerythritol trinitrate reductase activity
K08M3_45410	COG1063	alcohol dehydrogenase
K08M3_45430	COG1028	Short-chain dehydrogenase reductase Sdr
K08M3_45450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K08M3_45460	COG0006	proline dipeptidase activity
K08M3_45470	COG3608	succinylglutamate desuccinylase aspartoacylase
K08M3_45480	COG1522	sequence-specific DNA binding
K08M3_45490	COG1012	belongs to the aldehyde dehydrogenase family
K08M3_45500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K08M3_45510	COG3122	Protein conserved in bacteria
K08M3_45540	COG0583	DNA-binding transcription factor activity
K08M3_45560	COG0252	asparaginase activity
K08M3_45570	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K08M3_45600	COG2197	response regulator
K08M3_45610	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K08M3_45620	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K08M3_45660	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K08M3_45720	COG3842	ATPase activity
K08M3_45760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K08M3_45820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K08M3_45830	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K08M3_45890	COG0583	DNA-binding transcription factor activity
K08M3_45910	COG4948	Mandelate Racemase Muconate Lactonizing
K08M3_45920	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K08M3_45970	COG1342	Belongs to the UPF0251 family
K08M3_45980	COG4176	ABC-type proline glycine betaine transport system permease component
K08M3_45990	COG4175	Glycine betaine
K08M3_45990	COG3448	diguanylate cyclase activity
K08M3_46000	COG3015	lipoprotein NlpE involved in copper resistance
K08M3_46010	COG3713	MltA-interacting MipA family protein
K08M3_46040	COG0583	DNA-binding transcription factor activity
K08M3_46090	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K08M3_46110	COG1335	isochorismatase
K08M3_46140	COG1349	DNA-binding transcription factor activity
K08M3_46160	COG2070	2-Nitropropane dioxygenase
K08M3_46170	COG0531	amino acid
K08M3_46180	COG4302	ethanolamine ammonia-lyase activity
K08M3_46190	COG4303	Ethanolamine ammonia lyase large subunit
K08M3_46210	COG1309	transcriptional regulator
K08M3_46250	COG1280	lysine exporter protein (LysE YggA)
K08M3_46270	COG0459	protein refolding
K08M3_46280	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K08M3_46290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K08M3_46320	COG1304	FMN binding
K08M3_46430	COG2070	2-Nitropropane dioxygenase
K08M3_46440	COG0531	amino acid
K08M3_46450	COG4302	ethanolamine ammonia-lyase activity
K08M3_46460	COG4303	Ethanolamine ammonia lyase large subunit
K08M3_46480	COG1309	transcriptional regulator
K08M3_46520	COG1280	lysine exporter protein (LysE YggA)
K08M3_46540	COG0459	protein refolding
K08M3_46550	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K08M3_46560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K08M3_46590	COG1304	FMN binding
K08M3_46640	COG4786	Flagellar basal body rod
K08M3_46640	COG1256	bacterial-type flagellum assembly
K08M3_46660	COG1706	bacterial-type flagellum-dependent cell motility
K08M3_46670	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K08M3_46680	COG4786	Flagellar basal body rod
K08M3_46690	COG4787	bacterial-type flagellum-dependent cell motility
K08M3_46700	COG1749	Flagellar hook protein flgE
K08M3_46710	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K08M3_46720	COG1558	bacterial-type flagellum-dependent cell motility
K08M3_46730	COG1815	bacterial-type flagellum-dependent cell motility
K08M3_46770	COG0741	lytic transglycosylase activity
K08M3_46780	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K08M3_46820	COG1760	l-serine dehydratase
K08M3_46850	COG0583	DNA-binding transcription factor activity
K08M3_46870	COG2866	Carboxypeptidase
K08M3_46880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K08M3_46900	COG2990	Protein conserved in bacteria
K08M3_46950	COG3842	ATPase activity
K08M3_46970	COG1840	ABC-type Fe3 transport system, periplasmic component
K08M3_47010	COG1609	Transcriptional regulator
K08M3_47070	COG3240	lipase activity
K08M3_47080	COG1309	transcriptional regulator
K08M3_47110	COG1136	(ABC) transporter
K08M3_47110	COG0577	efflux transmembrane transporter activity
K08M3_47120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K08M3_47130	COG2067	long-chain fatty acid transport protein
K08M3_47140	COG3338	carbonate dehydratase activity
K08M3_47150	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K08M3_47180	COG1011	Hydrolase
K08M3_47250	COG0110	maltose O-acetyltransferase activity
K08M3_47260	COG1765	OsmC-like protein
K08M3_47270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K08M3_47270	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K08M3_47290	COG3046	protein related to deoxyribodipyrimidine photolyase
K08M3_47300	COG0415	Belongs to the DNA photolyase family
K08M3_47310	COG3706	GGDEF domain
K08M3_47340	COG3706	GGDEF domain
K08M3_47370	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K08M3_47400	COG3033	Beta-eliminating lyase
K08M3_47430	COG1271	oxidase subunit
K08M3_47440	COG1294	oxidase, subunit
K08M3_47470	COG3179	chitinase
K08M3_47480	COG0579	oxidoreductase
K08M3_47530	COG3706	GGDEF domain
K08M3_47590	COG0583	DNA-binding transcription factor activity
K08M3_47630	COG0189	ligase activity
K08M3_47640	COG0189	ligase activity
K08M3_47640	COG4067	protein conserved in archaea
K08M3_47660	COG1166	arginine decarboxylase activity
K08M3_47670	COG0010	Belongs to the arginase family
K08M3_47680	COG2814	Major facilitator Superfamily
K08M3_47690	COG1770	oligopeptidase
K08M3_47720	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K08M3_47730	COG1121	(ABC) transporter
K08M3_47740	COG0803	Belongs to the bacterial solute-binding protein 9 family
K08M3_47820	COG0848	biopolymer transport protein
K08M3_47830	COG0811	peptide transport
K08M3_47840	COG0811	peptide transport
K08M3_47880	COG0745	RESPONSE REGULATOR receiver
K08M3_47890	COG0584	glycerophosphoryl diester phosphodiesterase
K08M3_47910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K08M3_48040	COG0312	modulator of DNA gyrase
K08M3_48050	COG0312	modulator of DNA gyrase
K08M3_48060	COG0351	phosphomethylpyrimidine kinase
K08M3_48070	COG1116	anion transmembrane transporter activity
K08M3_48080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K08M3_48090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K08M3_48100	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K08M3_48140	COG0243	molybdopterin cofactor binding
K08M3_48150	COG3005	denitrification pathway
K08M3_48160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K08M3_48170	COG1028	Short-chain dehydrogenase reductase Sdr
K08M3_48200	COG0456	acetyltransferase
K08M3_48240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K08M3_48250	COG1929	Belongs to the glycerate kinase type-1 family
K08M3_48260	COG2610	gluconate transmembrane transporter activity
K08M3_48270	COG3835	regulator
K08M3_48400	COG3047	cAMP biosynthetic process
K08M3_48420	COG1357	PFAM Pentapeptide repeats (8 copies)
K08M3_48480	COG2375	cellular response to nickel ion
K08M3_48490	COG0583	DNA-binding transcription factor activity
K08M3_48500	COG2162	N-hydroxyarylamine O-acetyltransferase activity
K08M3_48510	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K08M3_48560	COG2199	diguanylate cyclase activity
K08M3_48580	COG0561	phosphatase activity
K08M3_48590	COG0583	DNA-binding transcription factor activity
K08M3_48620	COG0564	pseudouridine synthase activity
K08M3_48630	COG0534	Mate efflux family protein
K08M3_48640	COG5001	Diguanylate cyclase
K08M3_48660	COG3123	guanosine phosphorylase activity
K08M3_48690	COG0596	Alpha beta hydrolase
K08M3_48750	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K08M3_48770	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K08M3_48780	COG2169	Transcriptional regulator
K08M3_48780	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K08M3_48800	COG2259	Doxx family
K08M3_48810	COG1741	Belongs to the pirin family
K08M3_48850	COG0363	glucosamine-6-phosphate deaminase activity
K08M3_48870	COG0786	glutamate:sodium symporter activity
K08M3_48880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K08M3_48890	COG1131	(ABC) transporter
K08M3_48910	COG0786	glutamate:sodium symporter activity
K08M3_48950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K08M3_48970	COG3279	Response regulator of the LytR AlgR family
K08M3_48980	COG3275	phosphorelay sensor kinase activity
K08M3_49040	COG0772	Belongs to the SEDS family
K08M3_49090	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K08M3_49090	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
K08M3_49110	COG0444	Belongs to the ABC transporter superfamily
K08M3_49120	COG4608	Belongs to the ABC transporter superfamily
K08M3_50070	COG0358	DNA primase activity
K08M3_50410	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K08M3_50800	COG2916	Histone family protein nucleoid-structuring protein H-NS
K08M3_51350	COG0330	HflC and HflK could
K08M3_51360	COG0330	HflC and HflK could
K08M3_51470	COG3706	GGDEF domain
K08M3_51470	COG5001	Diguanylate cyclase
K08M3_51470	COG2203	Gaf domain
K08M3_51470	COG4251	negative regulation of phosphorylation
K08M3_51800	COG5001	Diguanylate cyclase
K08M3_51800	COG4251	negative regulation of phosphorylation
K08M3_51800	COG2203	Gaf domain
K08M3_51800	COG3706	GGDEF domain
K08M3_52030	COG0358	DNA primase activity