locus-tag	class	description
K08M4_00020	COG0592	DNA-directed DNA polymerase activity
K08M4_00040	COG0187	DNA topoisomerase II activity
K08M4_00050	COG0071	Belongs to the small heat shock protein (HSP20) family
K08M4_00060	COG3977	Valine--pyruvate aminotransferase
K08M4_00090	COG2119	membrane
K08M4_00140	COG0604	alcohol dehydrogenase
K08M4_00170	COG1739	Uncharacterized protein family UPF0029
K08M4_00180	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K08M4_00190	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
K08M4_00280	COG3335	DDE superfamily endonuclease
K08M4_00300	COG2132	Multicopper oxidase
K08M4_00340	COG0352	thiamine-phosphate diphosphorylase activity
K08M4_00350	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K08M4_00360	COG2104	thiamine diphosphate biosynthetic process
K08M4_00390	COG0006	proline dipeptidase activity
K08M4_00390	COG0006	proline dipeptidase activity
K08M4_00400	COG0583	DNA-binding transcription factor activity
K08M4_00450	COG3220	belongs to the UPF0276 family
K08M4_00470	COG0210	DNA helicase
K08M4_00490	COG0405	Gamma-glutamyltransferase
K08M4_00500	COG1280	lysine exporter protein (LysE YggA)
K08M4_00520	COG2962	Rard protein
K08M4_00530	COG0514	ATP-dependent DNA helicase (RecQ)
K08M4_00550	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K08M4_00580	COG3118	belongs to the thioredoxin family
K08M4_00590	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K08M4_00610	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K08M4_00620	COG2871	sodium ion transport
K08M4_00730	COG3335	DDE superfamily endonuclease
K08M4_00750	COG3335	DDE superfamily endonuclease
K08M4_00770	COG3071	HemY protein
K08M4_00780	COG2959	enzyme of heme biosynthesis
K08M4_00790	COG1587	Uroporphyrinogen-III synthase
K08M4_00810	COG3072	Adenylate cyclase
K08M4_00830	COG0019	diaminopimelate decarboxylase activity
K08M4_00870	COG1011	Hydrolase
K08M4_00880	COG3287	FIST C domain
K08M4_00880	COG2200	EAL domain
K08M4_00880	COG2199	diguanylate cyclase activity
K08M4_00890	COG3287	FIST C domain
K08M4_00890	COG2199	diguanylate cyclase activity
K08M4_00890	COG2200	EAL domain
K08M4_00930	COG0561	phosphatase activity
K08M4_00940	COG2267	carboxylic ester hydrolase activity
K08M4_00950	COG1280	lysine exporter protein (LysE YggA)
K08M4_00960	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K08M4_00970	COG0640	Transcriptional regulator
K08M4_00980	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K08M4_01060	COG2095	MarC family integral membrane protein
K08M4_01080	COG0742	ribosomal rna small subunit methyltransferase
K08M4_01090	COG0552	protein localization to endoplasmic reticulum
K08M4_01100	COG2884	Cell division ATP-binding protein ftsE
K08M4_01110	COG2177	Part of the ABC transporter FtsEX involved in
K08M4_01140	COG0705	Rhomboid family
K08M4_01150	COG1580	Controls the rotational direction of flagella during chemotaxis
K08M4_01160	COG3161	chorismate lyase activity
K08M4_01190	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K08M4_01210	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K08M4_01220	COG0534	Mate efflux family protein
K08M4_01270	COG4206	TonB-dependent receptor
K08M4_01290	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K08M4_01420	COG3335	DDE superfamily endonuclease
K08M4_01440	COG3335	DDE superfamily endonuclease
K08M4_01450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K08M4_01470	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K08M4_01490	COG1072	(Pantothenic acid kinase))
K08M4_01550	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K08M4_01560	COG0250	Participates in transcription elongation, termination and antitermination
K08M4_01590	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K08M4_01630	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
K08M4_01650	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K08M4_01660	COG1573	uracil-dna glycosylase
K08M4_01680	COG3068	Protein conserved in bacteria
K08M4_01690	COG1253	flavin adenine dinucleotide binding
K08M4_01720	COG0151	Belongs to the GarS family
K08M4_01740	COG0789	Transcriptional regulator
K08M4_01750	COG3706	GGDEF domain
K08M4_01770	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K08M4_01790	COG0439	Biotin carboxylase
K08M4_01800	COG0511	ligase activity, forming carbon-carbon bonds
K08M4_01810	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K08M4_01820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K08M4_01850	COG2814	Major facilitator Superfamily
K08M4_01860	COG2198	Histidine kinase
K08M4_01860	COG2205	protein histidine kinase activity
K08M4_01860	COG0784	Response regulator, receiver
K08M4_01890	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K08M4_01910	COG3263	regulation of cellular component size
K08M4_01930	COG4232	protein-disulfide reductase activity
K08M4_01940	COG1438	arginine binding
K08M4_01950	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K08M4_01960	COG0540	Belongs to the ATCase OTCase family
K08M4_01970	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K08M4_02000	COG1288	antiporter activity
K08M4_02010	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K08M4_02020	COG1027	Aspartate ammonia-lyase
K08M4_02040	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K08M4_02050	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K08M4_02060	COG2205	protein histidine kinase activity
K08M4_02070	COG0745	RESPONSE REGULATOR receiver
K08M4_02090	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K08M4_02130	COG3152	Membrane
K08M4_02160	COG1494	fructose-1,6-bisphosphatase
K08M4_02180	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K08M4_02190	COG1575	Belongs to the MenA family. Type 1 subfamily
K08M4_02230	COG1609	Transcriptional regulator
K08M4_02240	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K08M4_02260	COG0281	malic enzyme
K08M4_02280	COG0626	cystathionine gamma-synthase activity
K08M4_02290	COG0527	aspartate kinase activity
K08M4_02290	COG0460	homoserine dehydrogenase
K08M4_02300	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K08M4_02340	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K08M4_02370	COG0165	Argininosuccinate lyase
K08M4_02370	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K08M4_02380	COG0251	oxidation-reduction process
K08M4_02390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K08M4_02400	COG0678	peroxiredoxin activity
K08M4_02400	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K08M4_02420	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K08M4_02510	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K08M4_02520	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K08M4_02530	COG0546	phosphoglycolate phosphatase activity
K08M4_02540	COG0180	Tryptophanyl-tRNA synthetase
K08M4_02570	COG0512	Glutamine amidotransferase of anthranilate synthase
K08M4_02580	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K08M4_02620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K08M4_02630	COG3954	Phosphoribulokinase
K08M4_02650	COG0429	hydrolase of the alpha beta-hydrolase fold
K08M4_02670	COG0488	(ABC) transporter
K08M4_02680	COG2249	NAD(P)H dehydrogenase (quinone) activity
K08M4_02710	COG1047	Peptidyl-prolyl cis-trans
K08M4_02720	COG1446	asparaginase
K08M4_02750	COG0545	Peptidyl-prolyl cis-trans isomerase
K08M4_02760	COG2964	Protein conserved in bacteria
K08M4_02770	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
K08M4_02780	COG2923	Belongs to the DsrF TusC family
K08M4_02820	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K08M4_02840	COG0051	transcription antitermination factor activity, RNA binding
K08M4_02920	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K08M4_02950	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K08M4_02980	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K08M4_03050	COG0201	protein transport
K08M4_03070	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K08M4_03130	COG0545	Peptidyl-prolyl cis-trans isomerase
K08M4_03140	COG3266	domain, Protein
K08M4_03140	COG3061	Opacity-associated protein A
K08M4_03160	COG2153	protein acetylation
K08M4_03240	COG0737	Belongs to the 5'-nucleotidase family
K08M4_03270	COG3273	potassium ion transport
K08M4_03270	COG0471	metal ion transport
K08M4_03280	COG0529	Catalyzes the synthesis of activated sulfate
K08M4_03360	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K08M4_03380	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K08M4_03390	COG0729	surface antigen
K08M4_03410	COG2105	PFAM AIG2 family protein
K08M4_03430	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K08M4_03440	COG0163	prenyltransferase activity
K08M4_03450	COG4143	(ABC) transporter
K08M4_03460	COG1178	ABC-type Fe3 transport system permease component
K08M4_03470	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K08M4_03490	COG0312	modulator of DNA gyrase
K08M4_03500	COG2239	Acts as a magnesium transporter
K08M4_03510	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K08M4_03530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K08M4_03540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K08M4_03560	COG1137	ATPase activity
K08M4_03570	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K08M4_03590	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
K08M4_03600	COG0517	IMP dehydrogenase activity
K08M4_03600	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K08M4_03620	COG1127	ABC transporter
K08M4_03630	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K08M4_03640	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K08M4_03650	COG2854	intermembrane phospholipid transfer
K08M4_03670	COG5007	Belongs to the BolA IbaG family
K08M4_03690	COG0204	Acyl-transferase
K08M4_03700	COG0251	oxidation-reduction process
K08M4_03710	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K08M4_03780	COG0456	acetyltransferase
K08M4_03790	COG0525	valine-tRNA ligase activity
K08M4_03800	COG2927	DNA polymerase III (CHI subunit)
K08M4_03810	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K08M4_03820	COG0795	lipopolysaccharide-transporting ATPase activity
K08M4_03830	COG0795	lipopolysaccharide-transporting ATPase activity
K08M4_04060	COG0840	transmembrane signaling receptor activity
K08M4_04140	COG0741	lytic transglycosylase activity
K08M4_04190	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K08M4_04200	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K08M4_04230	COG0762	integral membrane protein
K08M4_04240	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K08M4_04250	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K08M4_04290	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K08M4_04310	COG0189	ligase activity
K08M4_04320	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K08M4_04340	COG2356	endonuclease I
K08M4_04390	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K08M4_04470	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
K08M4_04480	COG0588	phosphoglycerate mutase activity
K08M4_04490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K08M4_04510	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K08M4_04530	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K08M4_04550	COG0745	RESPONSE REGULATOR receiver
K08M4_04560	COG0784	Response regulator, receiver
K08M4_04560	COG2198	Histidine kinase
K08M4_04560	COG5002	protein histidine kinase activity
K08M4_04620	COG0191	fructose-bisphosphate aldolase activity
K08M4_04630	COG0668	transmembrane transport
K08M4_04640	COG1279	arginine transmembrane transporter activity
K08M4_04670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K08M4_04690	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K08M4_04700	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K08M4_04720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K08M4_04730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K08M4_04770	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K08M4_04780	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K08M4_04790	COG1595	DNA-templated transcription, initiation
K08M4_04840	COG0681	Belongs to the peptidase S26 family
K08M4_04900	COG2205	protein histidine kinase activity
K08M4_04900	COG4999	Histidine kinase
K08M4_04900	COG3850	Histidine kinase
K08M4_04900	COG3437	response regulator, receiver
K08M4_04920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K08M4_04930	COG3956	TIGRFAM MazG family protein
K08M4_04950	COG0148	phosphopyruvate hydratase activity
K08M4_04990	COG0585	pseudouridine synthase activity
K08M4_05000	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K08M4_05020	COG4942	peptidase
K08M4_05020	COG1388	LysM domain
K08M4_05030	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K08M4_05050	COG1546	Belongs to the CinA family
K08M4_05060	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K08M4_05100	COG3833	ABC-type maltose transport systems, permease component
K08M4_05110	COG1175	transmembrane transport
K08M4_05120	COG2182	Extracellular solute-binding protein
K08M4_05140	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K08M4_05160	COG3842	ATPase activity
K08M4_05210	COG0527	aspartate kinase activity
K08M4_05340	COG0511	ligase activity, forming carbon-carbon bonds
K08M4_05340	COG5016	pyruvate
K08M4_05350	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K08M4_05370	COG1238	metal cluster binding
K08M4_05380	COG0612	Peptidase, M16
K08M4_05420	COG4536	flavin adenine dinucleotide binding
K08M4_05430	COG4137	Cytochrome C assembly protein
K08M4_05440	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K08M4_05490	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K08M4_05510	COG0237	dephospho-CoA kinase activity
K08M4_05530	COG1459	type II secretion system
K08M4_05540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K08M4_05560	COG0157	Belongs to the NadC ModD family
K08M4_05580	COG2186	Transcriptional regulator
K08M4_05590	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K08M4_05600	COG0508	dehydrogenase complex catalyzes the overall conversion of
K08M4_05610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K08M4_05640	COG0288	reversible hydration of carbon dioxide
K08M4_05650	COG0659	secondary active sulfate transmembrane transporter activity
K08M4_05660	COG1131	(ABC) transporter
K08M4_05670	COG0842	Transport permease protein
K08M4_05700	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K08M4_05730	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K08M4_05750	COG1643	Atp-dependent helicase
K08M4_05760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K08M4_05770	COG1752	Esterase of the alpha-beta hydrolase superfamily
K08M4_05780	COG1049	propionate catabolic process, 2-methylcitrate cycle
K08M4_05820	COG0004	ammonium transporteR
K08M4_05830	COG1840	ABC-type Fe3 transport system, periplasmic component
K08M4_05850	COG3842	ATPase activity
K08M4_05860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K08M4_05890	COG2971	BadF BadG BcrA BcrD
K08M4_05910	COG4608	Belongs to the ABC transporter superfamily
K08M4_05920	COG0444	Belongs to the ABC transporter superfamily
K08M4_05930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K08M4_05950	COG0747	negative chemotaxis
K08M4_05970	COG2813	Specifically methylates the guanine in position
K08M4_05980	COG0628	permease
K08M4_06040	COG0739	heme binding
K08M4_06050	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K08M4_06060	COG2239	Acts as a magnesium transporter
K08M4_06070	COG2027	D-alanyl-D-alanine carboxypeptidase
K08M4_06080	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K08M4_06090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K08M4_06100	COG1534	Rna-binding protein
K08M4_06120	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K08M4_06130	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K08M4_06150	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K08M4_06190	COG0195	Participates in both transcription termination and antitermination
K08M4_06270	COG0534	Mate efflux family protein
K08M4_06320	COG3153	acetyltransferase
K08M4_06400	COG0084	hydrolase, TatD family'
K08M4_06410	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K08M4_06440	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K08M4_06450	COG0813	purine-nucleoside phosphorylase activity
K08M4_06470	COG0560	Phosphoserine phosphatase
K08M4_06490	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K08M4_06500	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K08M4_06560	COG4628	conserved protein (DUF2132)
K08M4_06610	COG1022	Amp-dependent synthetase and ligase
K08M4_06670	COG4964	Belongs to the GSP D family
K08M4_06790	COG2226	methyltransferase
K08M4_06800	COG2059	Chromate
K08M4_06820	COG0583	DNA-binding transcription factor activity
K08M4_06880	COG2195	Cleaves the N-terminal amino acid of tripeptides
K08M4_06890	COG2252	PERMEase
K08M4_06960	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K08M4_06960	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K08M4_07010	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K08M4_07020	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K08M4_07040	COG0142	geranyltranstransferase activity
K08M4_07060	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K08M4_07090	COG0583	DNA-binding transcription factor activity
K08M4_07170	COG1686	Belongs to the peptidase S11 family
K08M4_07180	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K08M4_07190	COG0772	Belongs to the SEDS family
K08M4_07200	COG0768	penicillin binding
K08M4_07220	COG0799	negative regulation of ribosome biogenesis
K08M4_07230	COG1466	dna polymerase III delta subunit
K08M4_07240	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
K08M4_07260	COG2888	peptidyl-tyrosine sulfation
K08M4_07270	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K08M4_07280	COG4535	Mg2 and Co2 transporter CorC
K08M4_07300	COG1702	phosphate starvation-inducible protein PhoH
K08M4_07310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K08M4_07320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K08M4_07330	COG2706	6-phosphogluconolactonase activity
K08M4_07530	COG0012	GTP binding
K08M4_07550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K08M4_07600	COG2890	protein-(glutamine-N5) methyltransferase activity
K08M4_07610	COG3094	Invasion gene expression up-regulator, SirB
K08M4_07620	COG2912	Transglutaminase-like superfamily
K08M4_07650	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K08M4_07660	COG1187	pseudouridine synthase activity
K08M4_07670	COG2840	Smr protein MutS2
K08M4_07740	COG2217	Heavy metal translocating P-type atpase
K08M4_07740	COG2608	mercury ion transmembrane transporter activity
K08M4_07770	COG1028	Short-chain dehydrogenase reductase Sdr
K08M4_07850	COG1216	Glycosyl transferase, family 2
K08M4_07890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K08M4_07900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K08M4_08020	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
K08M4_08030	COG0835	chemotaxis
K08M4_08030	COG0784	Response regulator, receiver
K08M4_08040	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K08M4_08050	COG1815	bacterial-type flagellum-dependent cell motility
K08M4_08060	COG1558	bacterial-type flagellum-dependent cell motility
K08M4_08070	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K08M4_08080	COG1749	Flagellar hook protein flgE
K08M4_08090	COG4787	bacterial-type flagellum-dependent cell motility
K08M4_08100	COG4786	Flagellar basal body rod
K08M4_08130	COG3951	Flagellar rod assembly protein muramidase FlgJ
K08M4_08130	COG1705	Flagellar rod assembly protein muramidase FlgJ
K08M4_08180	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K08M4_08190	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K08M4_08210	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K08M4_08230	COG1516	flagellar protein fliS
K08M4_08240	COG2204	response regulator
K08M4_08250	COG4191	Histidine kinase
K08M4_08260	COG2204	response regulator
K08M4_08270	COG1677	Flagellar hook-basal body complex protein FliE
K08M4_08290	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K08M4_08390	COG1987	bacterial-type flagellum assembly
K08M4_08400	COG1684	flagellar biosynthetic protein fliR
K08M4_08440	COG0455	bacterial-type flagellum organization
K08M4_08470	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
K08M4_08480	COG0643	Histidine kinase
K08M4_08480	COG2198	Histidine kinase
K08M4_08490	COG2201	protein-glutamate methylesterase activity
K08M4_08500	COG1192	Involved in chromosome partitioning
K08M4_08520	COG0835	chemotaxis
K08M4_08540	COG4133	protoheme IX ABC transporter activity
K08M4_08550	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K08M4_08560	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K08M4_08570	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K08M4_08590	COG1138	Cytochrome C-type biogenesis protein
K08M4_08600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K08M4_08610	COG4235	cytochrome complex assembly
K08M4_08610	COG3088	subunit of a heme lyase
K08M4_08620	COG3088	subunit of a heme lyase
K08M4_08620	COG4235	cytochrome complex assembly
K08M4_08640	COG2067	long-chain fatty acid transport protein
K08M4_08650	COG2067	long-chain fatty acid transport protein
K08M4_08680	COG0183	Belongs to the thiolase family
K08M4_08690	COG1024	Enoyl-CoA hydratase
K08M4_08690	COG1250	3-hydroxyacyl-CoA dehydrogenase
K08M4_08710	COG2062	phosphohistidine phosphatase, SixA
K08M4_08720	COG2840	Smr protein MutS2
K08M4_08730	COG2890	protein-(glutamine-N5) methyltransferase activity
K08M4_08740	COG1280	lysine exporter protein (LysE YggA)
K08M4_08770	COG0745	RESPONSE REGULATOR receiver
K08M4_08780	COG2205	protein histidine kinase activity
K08M4_08820	COG3842	ATPase activity
K08M4_08830	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K08M4_08840	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K08M4_08850	COG2894	cell division
K08M4_08880	COG2951	lytic endotransglycosylase activity
K08M4_08890	COG0583	DNA-binding transcription factor activity
K08M4_08900	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K08M4_08940	COG2153	protein acetylation
K08M4_08950	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K08M4_08980	COG2860	membrane
K08M4_08990	COG3101	peptidyl-lysine hydroxylation
K08M4_09010	COG0431	NADPH-dependent FMN reductase
K08M4_09030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K08M4_09060	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K08M4_09100	COG0285	dihydrofolate synthase activity
K08M4_09110	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
K08M4_09120	COG1286	toxin biosynthetic process
K08M4_09130	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K08M4_09140	COG0583	DNA-binding transcription factor activity
K08M4_09150	COG0745	RESPONSE REGULATOR receiver
K08M4_09170	COG2832	Protein of unknown function (DUF454)
K08M4_09190	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K08M4_09250	COG1785	Belongs to the alkaline phosphatase family
K08M4_09290	COG2226	methyltransferase
K08M4_09320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K08M4_09330	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K08M4_09350	COG3139	Protein of unknown function (DUF1315)
K08M4_09360	COG0252	asparaginase activity
K08M4_09370	COG0616	signal peptide processing
K08M4_09380	COG1902	pentaerythritol trinitrate reductase activity
K08M4_09380	COG0446	pyridine nucleotide-disulphide oxidoreductase
K08M4_09390	COG0778	Nitroreductase
K08M4_09400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K08M4_09430	COG0123	including yeast histone deacetylase and acetoin utilization protein
K08M4_09450	COG1959	2 iron, 2 sulfur cluster binding
K08M4_09490	COG3083	sulfuric ester hydrolase activity
K08M4_09540	COG1757	Na H antiporter
K08M4_09550	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K08M4_09560	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K08M4_09570	COG2095	MarC family integral membrane protein
K08M4_09580	COG1012	belongs to the aldehyde dehydrogenase family
K08M4_09580	COG1454	alcohol dehydrogenase
K08M4_09620	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K08M4_09640	COG2056	Na+-H+ antiporter family
K08M4_09680	COG0346	lactoylglutathione lyase activity
K08M4_09690	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K08M4_09730	COG4656	Part of a membrane complex involved in electron transport
K08M4_09780	COG2204	response regulator
K08M4_09790	COG2198	Histidine kinase
K08M4_09800	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K08M4_09820	COG0521	Mo-molybdopterin cofactor biosynthetic process
K08M4_09840	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K08M4_09850	COG0314	molybdopterin synthase activity
K08M4_09860	COG3385	transposase activity
K08M4_09880	COG0601	transmembrane transport
K08M4_09890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K08M4_09900	COG0444	Belongs to the ABC transporter superfamily
K08M4_09920	COG0435	Glutathione S-transferase
K08M4_09950	COG0280	phosphate acetyltransferase
K08M4_09950	COG0857	belongs to the CobB CobQ family
K08M4_09960	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K08M4_09990	COG3706	GGDEF domain
K08M4_10000	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K08M4_10020	COG0653	protein targeting
K08M4_10030	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K08M4_10050	COG2186	Transcriptional regulator
K08M4_10080	COG0489	protein tyrosine kinase activity
K08M4_10100	COG2982	Protein involved in outer membrane biogenesis
K08M4_10110	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
K08M4_10120	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K08M4_10130	COG0659	secondary active sulfate transmembrane transporter activity
K08M4_10140	COG1530	ribonuclease E activity
K08M4_10150	COG0564	pseudouridine synthase activity
K08M4_10170	COG1399	metal-binding, possibly nucleic acid-binding protein
K08M4_10200	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K08M4_10250	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K08M4_10260	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K08M4_10270	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K08M4_10280	COG0470	DNA polymerase III
K08M4_10290	COG0084	hydrolase, TatD family'
K08M4_10330	COG0733	neurotransmitter:sodium symporter activity
K08M4_10360	COG4667	esterase of the alpha-beta hydrolase superfamily
K08M4_10370	COG0469	pyruvate kinase activity
K08M4_10380	COG1940	carbohydrate kinase activity
K08M4_10390	COG0835	chemotaxis
K08M4_10390	COG0784	Response regulator, receiver
K08M4_10420	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K08M4_10430	COG1028	Short-chain dehydrogenase reductase Sdr
K08M4_10440	COG0616	signal peptide processing
K08M4_10450	COG2719	SpoVR family
K08M4_10460	COG2718	Belongs to the UPF0229 family
K08M4_10470	COG2766	serine protein kinase
K08M4_10490	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K08M4_10510	COG1882	Formate acetyltransferase
K08M4_10550	COG4215	(ABC) transporter
K08M4_10560	COG4160	amino acid transport
K08M4_10580	COG0708	Exodeoxyribonuclease III
K08M4_10590	COG1770	oligopeptidase
K08M4_10600	COG2814	Major facilitator Superfamily
K08M4_10610	COG0840	transmembrane signaling receptor activity
K08M4_10620	COG2850	peptidyl-arginine hydroxylation
K08M4_10660	COG1199	ATP-dependent helicase activity
K08M4_10670	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K08M4_10690	COG1187	pseudouridine synthase activity
K08M4_10720	COG1278	Cold shock
K08M4_10740	COG0542	response to heat
K08M4_10750	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K08M4_10760	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K08M4_10810	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K08M4_10820	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K08M4_10870	COG3070	regulator of competence-specific genes
K08M4_10900	COG0745	RESPONSE REGULATOR receiver
K08M4_10920	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K08M4_10930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K08M4_10950	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
K08M4_10960	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K08M4_10970	COG0840	transmembrane signaling receptor activity
K08M4_11000	COG4067	protein conserved in archaea
K08M4_11000	COG0189	ligase activity
K08M4_11030	COG1801	Protein of unknown function DUF72
K08M4_11080	COG1271	oxidase subunit
K08M4_11090	COG1294	oxidase, subunit
K08M4_11100	COG4890	Cyd operon protein YbgT
K08M4_11120	COG0824	Thioesterase
K08M4_11130	COG0811	peptide transport
K08M4_11170	COG2885	chlorophyll binding
K08M4_11180	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
K08M4_11190	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K08M4_11200	COG1629	transport
K08M4_11200	COG4774	siderophore transport
K08M4_11210	COG2375	cellular response to nickel ion
K08M4_11220	COG4592	Periplasmic binding protein
K08M4_11230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K08M4_11240	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K08M4_11250	COG1120	ATPase activity
K08M4_11280	COG0784	Response regulator, receiver
K08M4_11280	COG5002	protein histidine kinase activity
K08M4_11310	COG0583	DNA-binding transcription factor activity
K08M4_11360	COG0745	RESPONSE REGULATOR receiver
K08M4_11370	COG0463	Glycosyl transferase, family 2
K08M4_11380	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K08M4_11400	COG1032	radical SAM domain protein
K08M4_11430	COG0583	DNA-binding transcription factor activity
K08M4_11440	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K08M4_11460	COG2350	Protein conserved in bacteria
K08M4_11470	COG1607	acyl-coa hydrolase
K08M4_11540	COG5001	Diguanylate cyclase
K08M4_11540	COG2203	Gaf domain
K08M4_11540	COG4251	negative regulation of phosphorylation
K08M4_11540	COG3706	GGDEF domain
K08M4_11550	COG0840	transmembrane signaling receptor activity
K08M4_11590	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K08M4_11600	COG4136	ATPase activity
K08M4_11610	COG4135	transport system, permease component
K08M4_11620	COG4134	Bacterial extracellular solute-binding protein
K08M4_11640	COG3313	Fe-S protein
K08M4_11680	COG0513	Belongs to the DEAD box helicase family
K08M4_11690	COG1280	lysine exporter protein (LysE YggA)
K08M4_11710	COG2866	Carboxypeptidase
K08M4_11750	COG4176	ABC-type proline glycine betaine transport system permease component
K08M4_11760	COG2113	Glycine betaine
K08M4_11780	COG0583	DNA-binding transcription factor activity
K08M4_11800	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K08M4_11810	COG4988	ABC transporter
K08M4_11820	COG0492	ferredoxin-NADP+ reductase activity
K08M4_11870	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K08M4_11900	COG2203	Gaf domain
K08M4_11900	COG2199	diguanylate cyclase activity
K08M4_11920	COG0745	RESPONSE REGULATOR receiver
K08M4_11920	COG3706	GGDEF domain
K08M4_11930	COG0471	metal ion transport
K08M4_11940	COG2949	membrane
K08M4_11950	COG0281	malic enzyme
K08M4_11960	COG1643	Atp-dependent helicase
K08M4_12050	COG0247	lactate metabolic process
K08M4_12050	COG0277	FAD linked oxidase domain protein
K08M4_12090	COG2986	histidine ammonia-lyase
K08M4_12110	COG0010	Belongs to the arginase family
K08M4_12120	COG1228	amidohydrolase
K08M4_12140	COG4326	sporulation control protein
K08M4_12220	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K08M4_12280	COG0488	(ABC) transporter
K08M4_12290	COG1309	transcriptional regulator
K08M4_12320	COG0010	Belongs to the arginase family
K08M4_12350	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K08M4_12360	COG0800	Aldolase
K08M4_12370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K08M4_12380	COG1917	Cupin 2, conserved barrel domain protein
K08M4_12430	COG2186	Transcriptional regulator
K08M4_12440	COG2186	Transcriptional regulator
K08M4_12450	COG0517	IMP dehydrogenase activity
K08M4_12480	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K08M4_12520	COG3033	Beta-eliminating lyase
K08M4_12600	COG0471	metal ion transport
K08M4_12610	COG4191	Histidine kinase
K08M4_12610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K08M4_12670	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K08M4_12690	COG0730	response to heat
K08M4_12710	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K08M4_12720	COG1280	lysine exporter protein (LysE YggA)
K08M4_12730	COG1115	amino acid carrier protein
K08M4_12770	COG1115	amino acid carrier protein
K08M4_12790	COG0776	regulation of translation
K08M4_12830	COG2378	regulation of single-species biofilm formation
K08M4_12840	COG0840	transmembrane signaling receptor activity
K08M4_12860	COG0583	DNA-binding transcription factor activity
K08M4_12880	COG2175	clavaminate synthase activity
K08M4_12910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K08M4_12930	COG0523	cobalamin synthesis protein
K08M4_12980	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K08M4_13000	COG1346	cytolysis
K08M4_13020	COG2925	Exonuclease
K08M4_13060	COG3122	Protein conserved in bacteria
K08M4_13100	COG0702	epimerase
K08M4_13110	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K08M4_13130	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K08M4_13170	COG2988	succinylglutamate desuccinylase activity
K08M4_13180	COG4139	cobalamin transport
K08M4_13280	COG1247	-acetyltransferase
K08M4_13300	COG2203	Gaf domain
K08M4_13300	COG2199	diguanylate cyclase activity
K08M4_13320	COG2814	Major facilitator Superfamily
K08M4_13330	COG0583	DNA-binding transcription factor activity
K08M4_13350	COG1451	nucleotide metabolic process
K08M4_13370	COG3063	Type IV pilus biogenesis stability protein PilW
K08M4_13410	COG2195	Cleaves the N-terminal amino acid of tripeptides
K08M4_13450	COG0582	viral genome integration into host DNA
K08M4_13530	COG2003	Belongs to the UPF0758 family
K08M4_13540	COG0328	RNA-DNA hybrid ribonuclease activity
K08M4_13660	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
K08M4_13670	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
K08M4_13730	COG1401	restriction endodeoxyribonuclease activity
K08M4_13770	COG0583	DNA-binding transcription factor activity
K08M4_13800	COG0840	transmembrane signaling receptor activity
K08M4_13830	COG4771	TonB-dependent receptor
K08M4_13850	COG0454	-acetyltransferase
K08M4_13880	COG0420	3'-5' exonuclease activity
K08M4_13890	COG0419	ATPase involved in DNA repair
K08M4_13940	COG3046	protein related to deoxyribodipyrimidine photolyase
K08M4_13950	COG0589	response to stress
K08M4_14000	COG2271	Major facilitator Superfamily
K08M4_14010	COG0584	glycerophosphoryl diester phosphodiesterase
K08M4_14030	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K08M4_14070	COG0494	nUDIX hydrolase
K08M4_14100	COG1187	pseudouridine synthase activity
K08M4_14170	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K08M4_14210	COG1051	belongs to the nudix hydrolase family
K08M4_14250	COG0346	lactoylglutathione lyase activity
K08M4_14300	COG0653	protein targeting
K08M4_14320	COG1028	Short-chain dehydrogenase reductase Sdr
K08M4_14380	COG0826	peptidase U32
K08M4_14410	COG1126	abc transporter atp-binding protein
K08M4_14420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K08M4_14430	COG4215	(ABC) transporter
K08M4_14440	COG4160	amino acid transport
K08M4_14460	COG0517	IMP dehydrogenase activity
K08M4_14590	COG1742	UPF0060 membrane protein
K08M4_14610	COG1538	Outer membrane efflux protein
K08M4_14640	COG0583	DNA-binding transcription factor activity
K08M4_14670	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K08M4_14690	COG0438	transferase activity, transferring glycosyl groups
K08M4_14740	COG0438	transferase activity, transferring glycosyl groups
K08M4_14750	COG2204	response regulator
K08M4_14770	COG3448	diguanylate cyclase activity
K08M4_14770	COG4175	Glycine betaine
K08M4_14780	COG4176	ABC-type proline glycine betaine transport system permease component
K08M4_14830	COG2885	chlorophyll binding
K08M4_14830	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K08M4_14850	COG1793	dna ligase
K08M4_14860	COG0534	Mate efflux family protein
K08M4_14870	COG0307	riboflavin synthase, alpha
K08M4_14910	COG0791	NLP P60 protein
K08M4_14920	COG0840	transmembrane signaling receptor activity
K08M4_14970	COG0303	'Molybdopterin
K08M4_14990	COG3842	ATPase activity
K08M4_15000	COG4662	Binding-protein-dependent transport system inner membrane component
K08M4_15030	COG4191	Histidine kinase
K08M4_15060	COG0488	(ABC) transporter
K08M4_15070	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K08M4_15110	COG3381	protein complex oligomerization
K08M4_15130	COG0243	molybdopterin cofactor binding
K08M4_15130	COG3383	formate dehydrogenase (NAD+) activity
K08M4_15140	COG0437	4 iron, 4 sulfur cluster binding
K08M4_15170	COG0004	ammonium transporteR
K08M4_15180	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K08M4_15190	COG3706	GGDEF domain
K08M4_15200	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K08M4_15210	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K08M4_15220	COG1177	transmembrane transport
K08M4_15230	COG1176	ABC-type spermidine putrescine transport system, permease component I
K08M4_15280	COG0037	tRNA processing
K08M4_15290	COG0589	response to stress
K08M4_15300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K08M4_15330	COG2217	Heavy metal translocating P-type atpase
K08M4_15350	COG2010	Cytochrome c
K08M4_15380	COG3278	Belongs to the heme-copper respiratory oxidase family
K08M4_15410	COG0784	Response regulator, receiver
K08M4_15410	COG5002	protein histidine kinase activity
K08M4_15420	COG2801	Transposase and inactivated derivatives
K08M4_15510	COG3335	DDE superfamily endonuclease
K08M4_15570	COG1067	ATP-dependent peptidase activity
K08M4_15630	COG0116	Belongs to the methyltransferase superfamily
K08M4_15630	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K08M4_15660	COG2902	Dehydrogenase
K08M4_15680	COG0308	aminopeptidase N
K08M4_15720	COG1956	GAF domain-containing protein
K08M4_15730	COG1132	(ABC) transporter
K08M4_15740	COG2995	paraquat-inducible protein a
K08M4_15750	COG3008	intermembrane lipid transfer
K08M4_15770	COG2996	Protein conserved in bacteria
K08M4_15800	COG0574	Belongs to the PEP-utilizing enzyme family
K08M4_15800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K08M4_15810	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K08M4_15840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K08M4_15850	COG4597	amino acid ABC transporter
K08M4_15860	COG0765	amino acid transport
K08M4_15870	COG1126	abc transporter atp-binding protein
K08M4_15880	COG0670	Belongs to the BI1 family
K08M4_15890	COG2920	part of a sulfur-relay system
K08M4_15910	COG0840	transmembrane signaling receptor activity
K08M4_15970	COG3706	GGDEF domain
K08M4_15980	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K08M4_15990	COG0602	queuosine metabolic process
K08M4_16000	COG0561	phosphatase activity
K08M4_16060	COG2828	Protein conserved in bacteria
K08M4_16070	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K08M4_16080	COG0372	Belongs to the citrate synthase family
K08M4_16090	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K08M4_16110	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K08M4_16170	COG4628	conserved protein (DUF2132)
K08M4_16180	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K08M4_16190	COG0363	glucosamine-6-phosphate deaminase activity
K08M4_16200	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K08M4_16210	COG4565	transcriptional regulatory protein
K08M4_16220	COG3290	protein histidine kinase activity
K08M4_16250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K08M4_16290	COG1342	Belongs to the UPF0251 family
K08M4_16450	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K08M4_16460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K08M4_16580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K08M4_16580	COG0072	phenylalanine-tRNA ligase activity
K08M4_16600	COG3706	GGDEF domain
K08M4_16600	COG0745	RESPONSE REGULATOR receiver
K08M4_16680	COG1643	Atp-dependent helicase
K08M4_16710	COG0395	ABC-type sugar transport system, permease component
K08M4_16730	COG1653	transport
K08M4_16740	COG1609	Transcriptional regulator
K08M4_16750	COG3459	Glycosyltransferase 36 associated
K08M4_16760	COG3842	ATPase activity
K08M4_16840	COG3706	GGDEF domain
K08M4_16870	COG0443	Heat shock 70 kDa protein
K08M4_16900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K08M4_16910	COG3283	Transcriptional regulator of aromatic amino acids metabolism
K08M4_16930	COG3106	COG3106 Predicted ATPase
K08M4_16980	COG5002	protein histidine kinase activity
K08M4_16980	COG0784	Response regulator, receiver
K08M4_17000	COG0494	nUDIX hydrolase
K08M4_17020	COG0814	amino acid
K08M4_17030	COG1760	l-serine dehydratase
K08M4_17040	COG0814	amino acid
K08M4_17060	COG0720	synthase
K08M4_17070	COG0840	transmembrane signaling receptor activity
K08M4_17080	COG0659	secondary active sulfate transmembrane transporter activity
K08M4_17090	COG0017	Asparaginyl-tRNA synthetase
K08M4_17120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K08M4_17140	COG3437	response regulator, receiver
K08M4_17140	COG2770	Histidine kinase
K08M4_17180	COG1448	Aminotransferase
K08M4_17220	COG2258	MOSC domain
K08M4_17230	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K08M4_17250	COG3852	Histidine kinase
K08M4_17260	COG2204	response regulator
K08M4_17280	COG3070	regulator of competence-specific genes
K08M4_17300	COG2431	L-lysine efflux transmembrane transporter activity
K08M4_17320	COG0076	glutamate decarboxylase activity
K08M4_17340	COG1737	Transcriptional regulator
K08M4_17360	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K08M4_17380	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K08M4_17490	COG0534	Mate efflux family protein
K08M4_17500	COG0702	epimerase
K08M4_17520	COG2814	Major facilitator Superfamily
K08M4_17540	COG1061	Type III restriction enzyme res subunit
K08M4_17550	COG3300	MHYT domain
K08M4_17550	COG5001	Diguanylate cyclase
K08M4_17580	COG0642	Histidine kinase
K08M4_17600	COG0586	Pfam SNARE associated Golgi protein
K08M4_17690	COG2026	Addiction module toxin, RelE StbE family
K08M4_17740	COG0517	IMP dehydrogenase activity
K08M4_17760	COG0517	IMP dehydrogenase activity
K08M4_17790	COG2124	cytochrome p450
K08M4_17850	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K08M4_17860	COG1780	Probably involved in ribonucleotide reductase function
K08M4_17880	COG0316	Belongs to the HesB IscA family
K08M4_17890	COG0719	Fe-S assembly protein
K08M4_17900	COG0719	Fe-S assembly protein
K08M4_17930	COG2166	iron-sulfur cluster assembly
K08M4_17940	COG0840	transmembrane signaling receptor activity
K08M4_17950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K08M4_17960	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K08M4_18010	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K08M4_18040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K08M4_18050	COG3108	Peptidase M15
K08M4_18060	COG2989	Protein conserved in bacteria
K08M4_18110	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K08M4_18130	COG4235	cytochrome complex assembly
K08M4_18130	COG3088	subunit of a heme lyase
K08M4_18150	COG1138	Cytochrome C-type biogenesis protein
K08M4_18160	COG3301	Polysulphide reductase, NrfD
K08M4_18170	COG0437	4 iron, 4 sulfur cluster binding
K08M4_18180	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
K08M4_18190	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
K08M4_18200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K08M4_18240	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K08M4_18250	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K08M4_18320	COG0019	diaminopimelate decarboxylase activity
K08M4_18400	COG0322	excinuclease ABC activity
K08M4_18410	COG2197	response regulator
K08M4_18420	COG0417	DNA replication proofreading
K08M4_18450	COG3099	Belongs to the UPF0263 family
K08M4_18470	COG1187	pseudouridine synthase activity
K08M4_18480	COG0009	L-threonylcarbamoyladenylate synthase
K08M4_18490	COG0613	PHP domain protein
K08M4_18510	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K08M4_18520	COG0512	Glutamine amidotransferase of anthranilate synthase
K08M4_18530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K08M4_18540	COG0135	phosphoribosylanthranilate isomerase activity
K08M4_18540	COG0134	indole-3-glycerol-phosphate synthase activity
K08M4_18570	COG1301	dicarboxylic acid transport
K08M4_18580	COG3385	transposase activity
K08M4_18600	COG0564	pseudouridine synthase activity
K08M4_18620	COG0733	neurotransmitter:sodium symporter activity
K08M4_18640	COG0626	cystathionine gamma-synthase activity
K08M4_18650	COG2818	Glycosylase
K08M4_18680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K08M4_18690	COG1983	PspC domain protein
K08M4_18710	COG1842	Phage shock protein A
K08M4_18720	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K08M4_18730	COG4166	transmembrane transport
K08M4_18740	COG4168	peptide transport system, permease
K08M4_18750	COG4171	peptide transport system, permease
K08M4_18770	COG4172	Belongs to the ABC transporter superfamily
K08M4_18800	COG1227	inorganic diphosphatase activity
K08M4_18820	COG0243	molybdopterin cofactor binding
K08M4_18830	COG3005	denitrification pathway
K08M4_18840	COG4459	periplasmic nitrate reductase
K08M4_18850	COG0390	transport system, permease component
K08M4_18860	COG2116	formate transmembrane transporter activity
K08M4_18930	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K08M4_18950	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K08M4_18960	COG3012	SEC-C Motif Domain Protein
K08M4_18970	COG0140	phosphoribosyl-ATP diphosphatase activity
K08M4_18970	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K08M4_18990	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K08M4_19000	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K08M4_19010	COG0131	Imidazoleglycerol-phosphate dehydratase
K08M4_19010	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K08M4_19020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K08M4_19050	COG1757	Na H antiporter
K08M4_19060	COG2916	Histone family protein nucleoid-structuring protein H-NS
K08M4_19070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K08M4_19110	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K08M4_19180	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K08M4_19210	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K08M4_19240	COG3012	SEC-C Motif Domain Protein
K08M4_19250	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K08M4_19250	COG0140	phosphoribosyl-ATP diphosphatase activity
K08M4_19280	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K08M4_19290	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K08M4_19300	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K08M4_19310	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K08M4_19310	COG0131	Imidazoleglycerol-phosphate dehydratase
K08M4_19340	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K08M4_19370	COG1757	Na H antiporter
K08M4_19380	COG2916	Histone family protein nucleoid-structuring protein H-NS
K08M4_19390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K08M4_19430	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K08M4_19500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K08M4_19530	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K08M4_19540	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
K08M4_19550	COG1674	ftsk spoiiie
K08M4_19560	COG1522	sequence-specific DNA binding
K08M4_19570	COG0686	Belongs to the AlaDH PNT family
K08M4_19590	COG0583	DNA-binding transcription factor activity
K08M4_19630	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K08M4_19640	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
K08M4_19660	COG0539	negative regulation of cytoplasmic translation
K08M4_19680	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K08M4_19710	COG1132	(ABC) transporter
K08M4_19720	COG2333	competence protein COMEC
K08M4_19720	COG0658	competence protein
K08M4_19740	COG4591	ABC-type transport system involved in lipoprotein release permease component
K08M4_19750	COG1136	(ABC) transporter
K08M4_19760	COG4591	ABC-type transport system involved in lipoprotein release permease component
K08M4_19780	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K08M4_19810	COG1252	NADH dehydrogenase
K08M4_19870	COG0537	adenosine 5'-monophosphoramidase activity
K08M4_19930	COG0517	IMP dehydrogenase activity
K08M4_19960	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K08M4_19980	COG1902	pentaerythritol trinitrate reductase activity
K08M4_19990	COG0346	lactoylglutathione lyase activity
K08M4_20000	COG0583	DNA-binding transcription factor activity
K08M4_20030	COG2015	COG2015, Alkyl sulfatase and related hydrolases
K08M4_20070	COG1309	transcriptional regulator
K08M4_20080	COG0583	DNA-binding transcription factor activity
K08M4_20110	COG3040	lipid binding
K08M4_20120	COG1228	amidohydrolase
K08M4_20140	COG1120	ATPase activity
K08M4_20150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K08M4_20280	COG1522	sequence-specific DNA binding
K08M4_20310	COG0583	DNA-binding transcription factor activity
K08M4_20320	COG1486	melibiose metabolic process
K08M4_20330	COG3394	polysaccharide catabolic process
K08M4_20340	COG0789	Transcriptional regulator
K08M4_20380	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K08M4_20430	COG0463	Glycosyl transferase, family 2
K08M4_20430	COG1216	Glycosyl transferase, family 2
K08M4_20440	COG0438	transferase activity, transferring glycosyl groups
K08M4_20450	COG3341	Caulimovirus viroplasmin
K08M4_20450	COG0328	RNA-DNA hybrid ribonuclease activity
K08M4_20520	COG3126	Type III secretion system lipoprotein chaperone (YscW)
K08M4_20530	COG1946	Acyl-CoA thioesterase
K08M4_20550	COG1522	sequence-specific DNA binding
K08M4_20560	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K08M4_20580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K08M4_20700	COG2855	membrane
K08M4_20730	COG1441	menaquinone biosynthetic process
K08M4_20740	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K08M4_20750	COG2267	carboxylic ester hydrolase activity
K08M4_20770	COG1169	isochorismate synthase
K08M4_20780	COG0436	Aminotransferase
K08M4_20800	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K08M4_20830	COG1555	photosystem II stabilization
K08M4_20840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K08M4_20850	COG0776	regulation of translation
K08M4_20860	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K08M4_20910	COG2204	response regulator
K08M4_20930	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K08M4_20940	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K08M4_20950	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K08M4_20980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K08M4_20980	COG3321	synthase
K08M4_21010	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K08M4_21010	COG2070	2-Nitropropane dioxygenase
K08M4_21020	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K08M4_21030	COG0318	PFAM AMP-dependent synthetase and ligase
K08M4_21040	COG0596	Alpha beta hydrolase
K08M4_21070	COG1214	PFAM Peptidase M22, glycoprotease
K08M4_21080	COG1199	ATP-dependent helicase activity
K08M4_21100	COG0788	formyltetrahydrofolate deformylase activity
K08M4_21110	COG3102	Protein conserved in bacteria
K08M4_21160	COG1918	ferrous iron import across plasma membrane
K08M4_21180	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
K08M4_21190	COG1121	(ABC) transporter
K08M4_21200	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K08M4_21230	COG0508	dehydrogenase complex catalyzes the overall conversion of
K08M4_21240	COG0567	Dehydrogenase, E1 component
K08M4_21260	COG1053	succinate dehydrogenase
K08M4_21270	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K08M4_21280	COG2009	succinate dehydrogenase
K08M4_21290	COG0372	Belongs to the citrate synthase family
K08M4_21300	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K08M4_21320	COG0033	Phosphoglucomutase
K08M4_21340	COG0596	Alpha beta hydrolase
K08M4_21400	COG1263	PTS System
K08M4_21400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K08M4_21400	COG2190	(PTS) system
K08M4_21410	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K08M4_21420	COG1846	Transcriptional regulator
K08M4_21420	COG1940	carbohydrate kinase activity
K08M4_21430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K08M4_21430	COG4651	solute:proton antiporter activity
K08M4_21440	COG0367	asparagine synthase
K08M4_21450	COG0250	Participates in transcription elongation, termination and antitermination
K08M4_21460	COG3104	oligopeptide transport
K08M4_21500	COG3710	Transcriptional regulator
K08M4_21530	COG0622	Phosphoesterase
K08M4_21580	COG1090	epimerase
K08M4_21590	COG0300	oxidoreductase activity
K08M4_21600	COG3118	belongs to the thioredoxin family
K08M4_21610	COG0330	HflC and HflK could
K08M4_21780	COG0330	HflC and HflK could
K08M4_21800	COG0789	Transcriptional regulator
K08M4_21840	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K08M4_21880	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K08M4_21890	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K08M4_21910	COG2190	(PTS) system
K08M4_21920	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K08M4_21930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K08M4_21940	COG2837	iron assimilation
K08M4_22000	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K08M4_22000	COG3264	Mechanosensitive ion channel
K08M4_22020	COG0189	ligase activity
K08M4_22040	COG1393	Belongs to the ArsC family
K08M4_22090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K08M4_22100	COG2716	regulation of RNA biosynthetic process
K08M4_22110	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K08M4_22140	COG4783	chaperone-mediated protein folding
K08M4_22150	COG1393	Belongs to the ArsC family
K08M4_22190	COG2233	PERMEase
K08M4_22200	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K08M4_22220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K08M4_22230	COG0121	glutamine amidotransferase
K08M4_22240	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K08M4_22250	COG1960	acyl-CoA dehydrogenase activity
K08M4_22270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K08M4_22290	COG2226	methyltransferase
K08M4_22310	COG0741	lytic transglycosylase activity
K08M4_22310	COG1388	LysM domain
K08M4_22330	COG3021	interspecies interaction between organisms
K08M4_22340	COG0347	Belongs to the P(II) protein family
K08M4_22380	COG0587	DNA-directed DNA polymerase activity
K08M4_22430	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K08M4_22440	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
K08M4_22460	COG0750	zinc metalloprotease
K08M4_22480	COG0575	Belongs to the CDS family
K08M4_22490	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K08M4_22500	COG0233	cytoplasmic translational termination
K08M4_22510	COG0528	UMP kinase activity
K08M4_22530	COG0052	Belongs to the universal ribosomal protein uS2 family
K08M4_22540	COG0024	Methionine aminopeptidase
K08M4_22570	COG0564	pseudouridine synthase activity
K08M4_22580	COG3098	single-species biofilm formation
K08M4_22640	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K08M4_22660	COG1720	tRNA m6t6A37 methyltransferase activity
K08M4_22730	COG3335	DDE superfamily endonuclease
K08M4_22740	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K08M4_22760	COG0366	Alpha amylase catalytic
K08M4_22770	COG1263	PTS System
K08M4_22770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K08M4_22780	COG1609	Transcriptional regulator
K08M4_22800	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K08M4_22810	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K08M4_22820	COG2011	ABC-type metal ion transport system permease component
K08M4_22830	COG1464	Belongs to the NlpA lipoprotein family
K08M4_22840	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
K08M4_22880	COG3706	GGDEF domain
K08M4_22890	COG1611	Belongs to the LOG family
K08M4_22910	COG0733	neurotransmitter:sodium symporter activity
K08M4_22940	COG0514	ATP-dependent DNA helicase (RecQ)
K08M4_22950	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K08M4_22960	COG3706	GGDEF domain
K08M4_22960	COG0745	RESPONSE REGULATOR receiver
K08M4_22970	COG2991	Protein conserved in bacteria
K08M4_22980	COG1477	protein flavinylation
K08M4_23050	COG0271	Belongs to the BolA IbaG family
K08M4_23080	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K08M4_23100	COG3248	Nucleoside-binding outer membrane protein
K08M4_23110	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K08M4_23120	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K08M4_23130	COG2166	iron-sulfur cluster assembly
K08M4_23140	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K08M4_23150	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
K08M4_23190	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K08M4_23200	COG1074	ATP-dependent DNA helicase activity
K08M4_23220	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K08M4_23250	COG3141	response to X-ray
K08M4_23280	COG2095	MarC family integral membrane protein
K08M4_23290	COG2171	N-acyltransferase activity
K08M4_23300	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K08M4_23300	COG0047	phosphoribosylformylglycinamidine synthase activity
K08M4_23330	COG0590	tRNA wobble adenosine to inosine editing
K08M4_23340	COG1253	flavin adenine dinucleotide binding
K08M4_23360	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K08M4_23440	COG3385	transposase activity
K08M4_23460	COG1301	dicarboxylic acid transport
K08M4_23490	COG0497	DNA recombination
K08M4_23500	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K08M4_23510	COG2914	Belongs to the UPF0125 (RnfH) family
K08M4_23520	COG2867	negative regulation of translational initiation
K08M4_23550	COG4067	protein conserved in archaea
K08M4_23550	COG0189	ligase activity
K08M4_23580	COG2391	methyltransferase activity
K08M4_23600	COG0204	Acyl-transferase
K08M4_23610	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K08M4_23620	COG1115	amino acid carrier protein
K08M4_23630	COG1584	GPR1 FUN34 yaaH family protein
K08M4_23660	COG0517	IMP dehydrogenase activity
K08M4_23660	COG0516	GMP reductase activity
K08M4_23670	COG1570	exodeoxyribonuclease VII activity
K08M4_23690	COG3706	GGDEF domain
K08M4_23720	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K08M4_23730	COG2976	Protein conserved in bacteria
K08M4_23800	COG2975	iron-sulfur cluster assembly
K08M4_23850	COG0822	iron-sulfur transferase activity
K08M4_23880	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
K08M4_23890	COG0483	inositol monophosphate 1-phosphatase activity
K08M4_23900	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K08M4_23910	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K08M4_23920	COG1862	Preprotein translocase
K08M4_23950	COG0517	IMP dehydrogenase activity
K08M4_23960	COG1609	Transcriptional regulator
K08M4_23970	COG1621	beta-fructofuranosidase activity
K08M4_23980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K08M4_23980	COG1263	PTS System
K08M4_23990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K08M4_24000	COG0840	transmembrane signaling receptor activity
K08M4_24010	COG0583	DNA-binding transcription factor activity
K08M4_24020	COG0450	alkyl hydroperoxide reductase
K08M4_24060	COG0704	Plays a role in the regulation of phosphate uptake
K08M4_24070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K08M4_24080	COG0581	inorganic phosphate transmembrane transporter activity
K08M4_24090	COG0573	inorganic phosphate transmembrane transporter activity
K08M4_24100	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K08M4_24110	COG0248	Ppx GppA phosphatase
K08M4_24130	COG5002	protein histidine kinase activity
K08M4_24140	COG0745	RESPONSE REGULATOR receiver
K08M4_24170	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K08M4_24190	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
K08M4_24200	COG3335	DDE superfamily endonuclease
K08M4_24290	COG0564	pseudouridine synthase activity
K08M4_24300	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K08M4_24310	COG0741	lytic transglycosylase activity
K08M4_24320	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K08M4_24330	COG0077	Prephenate dehydratase
K08M4_24330	COG1605	Chorismate mutase
K08M4_24350	COG5001	Diguanylate cyclase
K08M4_24360	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
K08M4_24390	COG0488	(ABC) transporter
K08M4_24410	COG0739	heme binding
K08M4_24420	COG0287	Prephenate dehydrogenase
K08M4_24420	COG1605	Chorismate mutase
K08M4_24430	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K08M4_24440	COG1472	Belongs to the glycosyl hydrolase 3 family
K08M4_24450	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K08M4_24480	COG1966	Carbon starvation protein
K08M4_24490	COG3275	phosphorelay sensor kinase activity
K08M4_24500	COG3279	Response regulator of the LytR AlgR family
K08M4_24520	COG1047	Peptidyl-prolyl cis-trans
K08M4_24550	COG0196	riboflavin kinase activity
K08M4_24560	COG0728	peptidoglycan biosynthetic process
K08M4_24580	COG0640	Transcriptional regulator
K08M4_24590	COG0583	DNA-binding transcription factor activity
K08M4_24600	COG1283	sodium-dependent phosphate transmembrane transporter activity
K08M4_24630	COG0730	response to heat
K08M4_24710	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K08M4_24720	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K08M4_24730	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K08M4_24750	COG0716	FMN binding
K08M4_24780	COG0513	Belongs to the DEAD box helicase family
K08M4_24800	COG1115	amino acid carrier protein
K08M4_24830	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K08M4_24840	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K08M4_24860	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K08M4_24920	COG0745	RESPONSE REGULATOR receiver
K08M4_24940	COG0784	Response regulator, receiver
K08M4_24940	COG2198	Histidine kinase
K08M4_24940	COG5002	protein histidine kinase activity
K08M4_24950	COG3706	GGDEF domain
K08M4_24950	COG2203	Gaf domain
K08M4_24950	COG4251	negative regulation of phosphorylation
K08M4_24950	COG5001	Diguanylate cyclase
K08M4_24960	COG1242	4 iron, 4 sulfur cluster binding
K08M4_24970	COG0070	glutamate synthase
K08M4_24970	COG0069	glutamate synthase activity
K08M4_24970	COG0067	glutamate synthase
K08M4_24990	COG0069	glutamate synthase activity
K08M4_24990	COG0067	glutamate synthase
K08M4_24990	COG0070	glutamate synthase
K08M4_25000	COG0493	'glutamate synthase
K08M4_25050	COG2860	membrane
K08M4_25060	COG0583	DNA-binding transcription factor activity
K08M4_25070	COG0730	response to heat
K08M4_25090	COG0505	Belongs to the CarA family
K08M4_25110	COG0494	nUDIX hydrolase
K08M4_25140	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K08M4_25150	COG0849	cell division
K08M4_25160	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K08M4_25190	COG0772	Belongs to the SEDS family
K08M4_25220	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K08M4_25230	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K08M4_25240	COG0768	penicillin binding
K08M4_25250	COG3116	cell division
K08M4_25270	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K08M4_25300	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K08M4_25310	COG2823	Periplasmic or secreted lipoprotein
K08M4_25320	COG2969	positive regulation of protein catabolic process
K08M4_25330	COG0625	glutathione transferase activity
K08M4_25340	COG2857	Cytochrome c1
K08M4_25350	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K08M4_25360	COG0723	plastoquinol--plastocyanin reductase activity
K08M4_25390	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K08M4_25400	COG3105	Protein conserved in bacteria
K08M4_25420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K08M4_25440	COG0187	DNA topoisomerase II activity
K08M4_25450	COG3150	esterase
K08M4_25470	COG3151	Protein conserved in bacteria
K08M4_25480	COG0494	nUDIX hydrolase
K08M4_25490	COG1538	Outer membrane efflux protein
K08M4_25510	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K08M4_25530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K08M4_25540	COG3025	triphosphatase activity
K08M4_25550	COG1392	Phosphate transport regulator
K08M4_25560	COG0306	phosphate transporter
K08M4_25570	COG4991	sh3 domain protein
K08M4_25590	COG3267	Type II secretory pathway component ExeA
K08M4_25590	COG3409	Peptidoglycan-binding domain 1 protein
K08M4_25600	COG0617	tRNA 3'-terminal CCA addition
K08M4_25620	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K08M4_25630	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K08M4_25650	COG0596	Alpha beta hydrolase
K08M4_25680	COG1610	YqeY-like protein
K08M4_25700	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K08M4_25720	COG2873	o-acetylhomoserine
K08M4_25730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K08M4_25740	COG1349	DNA-binding transcription factor activity
K08M4_25750	COG0469	pyruvate kinase activity
K08M4_25780	COG0028	Belongs to the TPP enzyme family
K08M4_25790	COG1022	Amp-dependent synthetase and ligase
K08M4_25870	COG0473	3-isopropylmalate dehydrogenase activity
K08M4_25880	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K08M4_25920	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K08M4_25930	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K08M4_25940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K08M4_25950	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K08M4_26000	COG3610	response to peptide
K08M4_26010	COG2966	Psort location CytoplasmicMembrane, score
K08M4_26050	COG0142	geranyltranstransferase activity
K08M4_26110	COG0589	response to stress
K08M4_26120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K08M4_26160	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K08M4_26170	COG0312	modulator of DNA gyrase
K08M4_26180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K08M4_26190	COG3164	Protein of unknown function
K08M4_26200	COG1530	ribonuclease E activity
K08M4_26210	COG0424	maF-like protein
K08M4_26220	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K08M4_26230	COG1792	Involved in formation and maintenance of cell shape
K08M4_26240	COG1077	Cell shape determining protein MreB Mrl
K08M4_26330	COG1459	type II secretion system
K08M4_26340	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K08M4_26360	COG3267	Type II secretory pathway component ExeA
K08M4_26360	COG3409	Peptidoglycan-binding domain 1 protein
K08M4_26410	COG2199	diguanylate cyclase activity
K08M4_26410	COG2200	EAL domain
K08M4_26420	COG0629	single-stranded DNA binding
K08M4_26430	COG2197	response regulator
K08M4_26450	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K08M4_26470	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K08M4_26480	COG0527	aspartate kinase activity
K08M4_26530	COG1484	DNA-dependent DNA replication
K08M4_26540	COG3335	DDE superfamily endonuclease
K08M4_26750	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K08M4_26840	COG3385	transposase activity
K08M4_26860	COG0432	Pfam Uncharacterised protein family UPF0047
K08M4_26890	COG0305	Participates in initiation and elongation during chromosome replication
K08M4_26940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K08M4_26950	COG0557	exoribonuclease II activity
K08M4_26960	COG0402	S-adenosylhomocysteine deaminase activity
K08M4_26970	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
K08M4_26980	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K08M4_26990	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
K08M4_27000	COG0330	HflC and HflK could
K08M4_27010	COG0330	HflC and HflK could
K08M4_27020	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K08M4_27050	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K08M4_27060	COG0860	N-Acetylmuramoyl-L-alanine amidase
K08M4_27070	COG0802	atpase or kinase
K08M4_27080	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K08M4_27250	COG1162	GTPase activity
K08M4_27270	COG0471	metal ion transport
K08M4_27270	COG0490	domain, Protein
K08M4_27280	COG0840	transmembrane signaling receptor activity
K08M4_27310	COG1053	succinate dehydrogenase
K08M4_27320	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K08M4_27370	COG1509	lysine 2,3-aminomutase activity
K08M4_27380	COG1285	pathogenesis
K08M4_27390	COG2199	diguanylate cyclase activity
K08M4_27390	COG2203	Gaf domain
K08M4_27410	COG0459	protein refolding
K08M4_27430	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
K08M4_27440	COG0534	Mate efflux family protein
K08M4_27470	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K08M4_27570	COG1215	transferase activity, transferring glycosyl groups
K08M4_27590	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K08M4_27700	COG0438	transferase activity, transferring glycosyl groups
K08M4_27710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K08M4_27740	COG1045	serine acetyltransferase
K08M4_27750	COG4942	peptidase
K08M4_27800	COG1088	dTDP-glucose 4,6-dehydratase activity
K08M4_27820	COG1560	Kdo2-lipid A biosynthetic process
K08M4_27840	COG4641	Protein conserved in bacteria
K08M4_27840	COG0438	transferase activity, transferring glycosyl groups
K08M4_27870	COG0859	PFAM glycosyl transferase family 9
K08M4_27890	COG3642	lipopolysaccharide core region biosynthetic process
K08M4_27920	COG1519	Transferase
K08M4_27930	COG0859	PFAM glycosyl transferase family 9
K08M4_27970	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K08M4_28000	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K08M4_28020	COG1560	Kdo2-lipid A biosynthetic process
K08M4_28050	COG1561	YicC-like family, N-terminal region
K08M4_28060	COG1278	Cold shock
K08M4_28080	COG0561	phosphatase activity
K08M4_28100	COG1454	alcohol dehydrogenase
K08M4_28110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K08M4_28120	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K08M4_28130	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K08M4_28140	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K08M4_28160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K08M4_28160	COG1263	PTS System
K08M4_28190	COG2252	PERMEase
K08M4_28220	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K08M4_28230	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K08M4_28240	COG2205	protein histidine kinase activity
K08M4_28250	COG0745	RESPONSE REGULATOR receiver
K08M4_28260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K08M4_28270	COG2183	response to ionizing radiation
K08M4_28300	COG1040	competence protein
K08M4_28310	COG0316	Belongs to the HesB IscA family
K08M4_28310	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K08M4_28320	COG0494	nUDIX hydrolase
K08M4_28330	COG1218	3'(2'),5'-bisphosphate nucleotidase
K08M4_28350	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K08M4_28360	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K08M4_28370	COG3156	type II secretion system protein K
K08M4_28380	COG4795	General secretion pathway protein
K08M4_28390	COG2165	general secretion pathway protein
K08M4_28400	COG2165	general secretion pathway protein
K08M4_28410	COG2165	general secretion pathway protein
K08M4_28420	COG1459	type II secretion system
K08M4_28430	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K08M4_28450	COG3031	protein transport across the cell outer membrane
K08M4_28460	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K08M4_28500	COG0456	acetyltransferase
K08M4_28560	COG0174	glutamine synthetase
K08M4_28580	COG3852	Histidine kinase
K08M4_28610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K08M4_28660	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K08M4_28680	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K08M4_28680	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K08M4_28710	COG0084	hydrolase, TatD family'
K08M4_28720	COG0805	protein transport
K08M4_28760	COG3165	ubiquinone biosynthetic process from chorismate
K08M4_28770	COG2226	methyltransferase
K08M4_28780	COG1322	Protein conserved in bacteria
K08M4_28800	COG2081	HI0933 family
K08M4_28830	COG0732	type I restriction modification DNA specificity domain
K08M4_28910	COG2081	HI0933 family
K08M4_28960	COG2081	HI0933 family
K08M4_28980	COG1528	Iron-storage protein
K08M4_28990	COG0589	response to stress
K08M4_29000	COG0697	spore germination
K08M4_29030	COG5002	protein histidine kinase activity
K08M4_29030	COG5001	Diguanylate cyclase
K08M4_29040	COG1522	sequence-specific DNA binding
K08M4_29050	COG0339	signal peptide processing
K08M4_29060	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K08M4_29070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K08M4_29130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K08M4_29150	COG0747	negative chemotaxis
K08M4_29240	COG1309	transcriptional regulator
K08M4_29250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K08M4_29260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K08M4_29270	COG2960	long-chain fatty acid transporting porin activity
K08M4_29290	COG0583	DNA-binding transcription factor activity
K08M4_29310	COG3335	DDE superfamily endonuclease
K08M4_29400	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K08M4_29440	COG0009	L-threonylcarbamoyladenylate synthase
K08M4_29450	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K08M4_29460	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K08M4_29470	COG0551	DNA topoisomerase type I activity
K08M4_29490	COG0758	DNA mediated transformation
K08M4_29530	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K08M4_29530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K08M4_29540	COG0569	domain protein
K08M4_29550	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K08M4_29570	COG1272	protein, Hemolysin III
K08M4_29580	COG4326	sporulation control protein
K08M4_29600	COG3084	Protein conserved in bacteria
K08M4_29630	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K08M4_29640	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K08M4_29660	COG0606	chelatase, subunit chli
K08M4_29680	COG3978	acetolactate synthase activity
K08M4_29690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K08M4_29720	COG0583	DNA-binding transcription factor activity
K08M4_29730	COG2814	Major facilitator Superfamily
K08M4_29750	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K08M4_29760	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K08M4_29770	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K08M4_29780	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K08M4_29800	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K08M4_29820	COG0356	it plays a direct role in the translocation of protons across the membrane
K08M4_29830	COG3312	ion transport
K08M4_29840	COG1475	DNA binding
K08M4_29850	COG1192	Involved in chromosome partitioning
K08M4_29880	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K08M4_29930	COG1126	abc transporter atp-binding protein
K08M4_29980	COG1444	tRNA N-acetyltransferase activity
K08M4_30010	COG2194	sulfuric ester hydrolase activity
K08M4_30090	COG1132	(ABC) transporter
K08M4_30100	COG4399	Belongs to the UPF0754 family
K08M4_30140	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K08M4_30190	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K08M4_30290	COG2205	protein histidine kinase activity
K08M4_30300	COG0745	RESPONSE REGULATOR receiver
K08M4_30370	COG0517	IMP dehydrogenase activity
K08M4_30370	COG4175	Glycine betaine
K08M4_30380	COG1846	Transcriptional regulator
K08M4_30410	COG0456	acetyltransferase
K08M4_30420	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K08M4_30440	COG0527	aspartate kinase activity
K08M4_30500	COG1803	Methylglyoxal synthase
K08M4_30500	COG1597	lipid kinase activity
K08M4_30510	COG0668	transmembrane transport
K08M4_30570	COG0628	permease
K08M4_30610	COG0800	Aldolase
K08M4_30620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K08M4_30630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K08M4_30630	COG1263	PTS System
K08M4_30660	COG2188	Transcriptional regulator
K08M4_30680	COG0110	maltose O-acetyltransferase activity
K08M4_30710	COG2207	Transcriptional regulator
K08M4_30720	COG2814	Major facilitator Superfamily
K08M4_30760	COG3547	Transposase (IS116 IS110 IS902 family)
K08M4_30790	COG2015	COG2015, Alkyl sulfatase and related hydrolases
K08M4_30820	COG0346	lactoylglutathione lyase activity
K08M4_30830	COG2723	6-phospho-beta-galactosidase activity
K08M4_30840	COG1609	Transcriptional regulator
K08M4_30850	COG0110	maltose O-acetyltransferase activity
K08M4_30860	COG2814	Major facilitator Superfamily
K08M4_30870	COG0583	DNA-binding transcription factor activity
K08M4_30890	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K08M4_30910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K08M4_30970	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K08M4_30980	COG1349	DNA-binding transcription factor activity
K08M4_31000	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K08M4_31050	COG2994	toxin metabolic process
K08M4_31060	COG1073	alpha beta
K08M4_31060	COG3064	Membrane
K08M4_31060	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
K08M4_31080	COG0583	DNA-binding transcription factor activity
K08M4_31090	COG0798	PFAM Bile acid sodium symporter
K08M4_31120	COG1309	transcriptional regulator
K08M4_31130	COG0561	phosphatase activity
K08M4_31160	COG4974	Belongs to the 'phage' integrase family
K08M4_31180	COG3214	Protein conserved in bacteria
K08M4_31270	COG0561	phosphatase activity
K08M4_31280	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
K08M4_31290	COG3623	hexulose-6-phosphate isomerase
K08M4_31310	COG1929	Belongs to the glycerate kinase type-1 family
K08M4_31320	COG0753	catalase activity
K08M4_31330	COG4667	esterase of the alpha-beta hydrolase superfamily
K08M4_31340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K08M4_31360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K08M4_31370	COG0204	Acyl-transferase
K08M4_31380	COG2384	SAM-dependent methyltransferase
K08M4_31460	COG0366	Alpha amylase catalytic
K08M4_31600	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
K08M4_31610	COG1162	GTPase activity
K08M4_31630	COG1999	signal sequence binding
K08M4_31670	COG0058	SHG alpha-glucan phosphorylase activity
K08M4_31680	COG1640	4-alpha-glucanotransferase
K08M4_31690	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K08M4_31710	COG1122	ATPase activity
K08M4_31730	COG1566	PFAM secretion protein HlyD family protein
K08M4_31760	COG3706	GGDEF domain
K08M4_31790	COG0813	purine-nucleoside phosphorylase activity
K08M4_31800	COG1376	ErfK ybiS ycfS ynhG family protein
K08M4_31800	COG1388	LysM domain
K08M4_31820	COG0513	Belongs to the DEAD box helicase family
K08M4_31830	COG3240	lipase activity
K08M4_31840	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
K08M4_31860	COG0840	transmembrane signaling receptor activity
K08M4_31870	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K08M4_31880	COG0573	inorganic phosphate transmembrane transporter activity
K08M4_31890	COG0581	inorganic phosphate transmembrane transporter activity
K08M4_31910	COG3706	GGDEF domain
K08M4_31930	COG2304	oxidoreductase activity
K08M4_31940	COG2304	oxidoreductase activity
K08M4_31970	COG0714	Associated with various cellular activities
K08M4_31980	COG0840	transmembrane signaling receptor activity
K08M4_32000	COG3385	transposase activity
K08M4_32010	COG3842	ATPase activity
K08M4_32030	COG1175	transmembrane transport
K08M4_32080	COG3385	transposase activity
K08M4_32130	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K08M4_32140	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K08M4_32160	COG0668	transmembrane transport
K08M4_32200	COG2239	Acts as a magnesium transporter
K08M4_32220	COG0387	Pfam Sodium calcium exchanger
K08M4_32230	COG0583	DNA-binding transcription factor activity
K08M4_32260	COG1136	(ABC) transporter
K08M4_32280	COG5001	Diguanylate cyclase
K08M4_32290	COG3300	MHYT domain
K08M4_32290	COG5001	Diguanylate cyclase
K08M4_32330	COG3706	GGDEF domain
K08M4_32430	COG1012	belongs to the aldehyde dehydrogenase family
K08M4_32450	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K08M4_32470	COG2354	Protein conserved in bacteria
K08M4_32500	COG0633	Ferredoxin
K08M4_32500	COG3217	Mosc domain protein beta barrel domain protein
K08M4_32600	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K08M4_32610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K08M4_32630	COG0848	biopolymer transport protein
K08M4_32640	COG0811	peptide transport
K08M4_32650	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K08M4_32670	COG3721	Heme iron utilization protein
K08M4_32680	COG0748	coenzyme F420 binding
K08M4_32690	COG0784	Response regulator, receiver
K08M4_32690	COG0835	chemotaxis
K08M4_32700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K08M4_32710	COG0366	Alpha amylase catalytic
K08M4_32780	COG0739	heme binding
K08M4_32790	COG5001	Diguanylate cyclase
K08M4_32800	COG0583	DNA-binding transcription factor activity
K08M4_32810	COG2814	Major facilitator Superfamily
K08M4_32850	COG0697	spore germination
K08M4_32860	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K08M4_32890	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K08M4_32900	COG3037	sugar-specific permease SgaT UlaA
K08M4_32940	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K08M4_32960	COG4106	trans-aconitate 2-methyltransferase activity
K08M4_32990	COG0513	Belongs to the DEAD box helicase family
K08M4_33020	COG3706	GGDEF domain
K08M4_33030	COG1278	Cold shock
K08M4_33040	COG0402	S-adenosylhomocysteine deaminase activity
K08M4_33050	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K08M4_33100	COG4413	Urea transporter
K08M4_33130	COG0531	amino acid
K08M4_33160	COG1280	lysine exporter protein (LysE YggA)
K08M4_33200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K08M4_33260	COG2827	Endonuclease containing a URI domain
K08M4_33310	COG0443	Heat shock 70 kDa protein
K08M4_33330	COG0179	Fumarylacetoacetate (FAA) hydrolase
K08M4_33340	COG1280	lysine exporter protein (LysE YggA)
K08M4_33350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K08M4_33370	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K08M4_33390	COG1845	cytochrome c oxidase, subunit III
K08M4_33430	COG1612	heme a metabolic process
K08M4_33440	COG0109	protoheme IX farnesyltransferase activity
K08M4_33470	COG3530	Putative quorum-sensing-regulated virulence factor
K08M4_33490	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
K08M4_33500	COG2944	sequence-specific DNA binding
K08M4_33560	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K08M4_33570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K08M4_33590	COG0668	transmembrane transport
K08M4_33600	COG0569	domain protein
K08M4_33610	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K08M4_33620	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K08M4_33620	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K08M4_33630	COG1765	OsmC-like protein
K08M4_33640	COG2885	chlorophyll binding
K08M4_33680	COG1840	ABC-type Fe3 transport system, periplasmic component
K08M4_33690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K08M4_33700	COG3842	ATPase activity
K08M4_33740	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K08M4_33760	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K08M4_33770	COG3265	gluconokinase activity
K08M4_33780	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K08M4_33800	COG1609	Transcriptional regulator
K08M4_33830	COG1760	l-serine dehydratase
K08M4_33890	COG1132	(ABC) transporter
K08M4_33900	COG1132	(ABC) transporter
K08M4_33920	COG0739	heme binding
K08M4_33930	COG0393	Putative heavy-metal-binding
K08M4_33980	COG0346	lactoylglutathione lyase activity
K08M4_34010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K08M4_34030	COG0577	efflux transmembrane transporter activity
K08M4_34030	COG1136	(ABC) transporter
K08M4_34040	COG0577	efflux transmembrane transporter activity
K08M4_34040	COG1136	(ABC) transporter
K08M4_34050	COG0577	efflux transmembrane transporter activity
K08M4_34050	COG1136	(ABC) transporter
K08M4_34070	COG2200	EAL domain
K08M4_34080	COG0156	8-amino-7-oxononanoate synthase activity
K08M4_34110	COG2249	NAD(P)H dehydrogenase (quinone) activity
K08M4_34170	COG1454	alcohol dehydrogenase
K08M4_34190	COG1011	Hydrolase
K08M4_34210	COG3706	GGDEF domain
K08M4_34210	COG2203	Gaf domain
K08M4_34210	COG5001	Diguanylate cyclase
K08M4_34210	COG4251	negative regulation of phosphorylation
K08M4_34250	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K08M4_34260	COG3385	transposase activity
K08M4_34270	COG3291	Pkd domain containing protein
K08M4_34270	COG4412	M6 family metalloprotease domain protein
K08M4_34300	COG1522	sequence-specific DNA binding
K08M4_34310	COG0840	transmembrane signaling receptor activity
K08M4_34320	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K08M4_34360	COG0583	DNA-binding transcription factor activity
K08M4_34400	COG4964	Belongs to the GSP D family
K08M4_34510	COG2203	Gaf domain
K08M4_34510	COG5001	Diguanylate cyclase
K08M4_34510	COG4251	negative regulation of phosphorylation
K08M4_34510	COG3706	GGDEF domain
K08M4_34520	COG2897	thiosulfate sulfurtransferase activity
K08M4_34580	COG0302	gtp cyclohydrolase
K08M4_34610	COG4681	YaeQ
K08M4_34620	COG1278	Cold shock
K08M4_34630	COG2133	pyrroloquinoline quinone binding
K08M4_34650	COG1120	ATPase activity
K08M4_34670	COG3708	Transcriptional regulator
K08M4_34670	COG2207	Transcriptional regulator
K08M4_34700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K08M4_34710	COG1024	Enoyl-CoA hydratase
K08M4_34740	COG1902	pentaerythritol trinitrate reductase activity
K08M4_34740	COG0446	pyridine nucleotide-disulphide oxidoreductase
K08M4_34770	COG1132	(ABC) transporter
K08M4_34820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K08M4_34830	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K08M4_34900	COG2824	Alkylphosphonate utilization operon protein PhnA
K08M4_34930	COG0765	amino acid transport
K08M4_34950	COG0765	amino acid transport
K08M4_34960	COG1126	abc transporter atp-binding protein
K08M4_34970	COG1979	alcohol dehydrogenase
K08M4_34980	COG2207	Transcriptional regulator
K08M4_35060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K08M4_35080	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K08M4_35100	COG2199	diguanylate cyclase activity
K08M4_35130	COG1686	Belongs to the peptidase S11 family
K08M4_35150	COG0564	pseudouridine synthase activity
K08M4_35170	COG2130	NADP-dependent
K08M4_35180	COG1309	transcriptional regulator
K08M4_35190	COG0545	Peptidyl-prolyl cis-trans isomerase
K08M4_35230	COG3604	Transcriptional regulator
K08M4_35240	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K08M4_35240	COG1017	nitric oxide dioxygenase activity
K08M4_35260	COG0038	chloride channel
K08M4_35270	COG0523	cobalamin synthesis protein
K08M4_35280	COG0513	Belongs to the DEAD box helicase family
K08M4_35290	COG1280	lysine exporter protein (LysE YggA)
K08M4_35360	COG0745	RESPONSE REGULATOR receiver
K08M4_35460	COG3005	denitrification pathway
K08M4_35470	COG3043	anaerobic respiration
K08M4_35510	COG3850	Histidine kinase
K08M4_35520	COG2197	response regulator
K08M4_35530	COG3069	C4-dicarboxylate transmembrane transporter activity
K08M4_35610	COG3188	usher protein
K08M4_35660	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
K08M4_35670	COG0494	nUDIX hydrolase
K08M4_35680	COG0714	Associated with various cellular activities
K08M4_35690	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K08M4_35710	COG0840	transmembrane signaling receptor activity
K08M4_35800	COG1858	cytochrome C peroxidase
K08M4_35810	COG1858	cytochrome C peroxidase
K08M4_35860	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K08M4_35870	COG2146	nitrite reductase [NAD(P)H] activity
K08M4_35880	COG2116	formate transmembrane transporter activity
K08M4_35920	COG0745	RESPONSE REGULATOR receiver
K08M4_35930	COG2205	protein histidine kinase activity
K08M4_35940	COG1301	dicarboxylic acid transport
K08M4_35950	COG4774	siderophore transport
K08M4_35970	COG0811	peptide transport
K08M4_35980	COG0811	peptide transport
K08M4_35990	COG0848	biopolymer transport protein
K08M4_36110	COG0803	Belongs to the bacterial solute-binding protein 9 family
K08M4_36160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K08M4_36160	COG1321	iron dependent repressor
K08M4_36230	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K08M4_36240	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K08M4_36250	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K08M4_36260	COG2146	nitrite reductase [NAD(P)H] activity
K08M4_36290	COG1648	precorrin-2 dehydrogenase activity
K08M4_36290	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K08M4_36340	COG0745	RESPONSE REGULATOR receiver
K08M4_36350	COG2205	protein histidine kinase activity
K08M4_36360	COG1301	dicarboxylic acid transport
K08M4_36370	COG4774	siderophore transport
K08M4_36390	COG0811	peptide transport
K08M4_36400	COG0811	peptide transport
K08M4_36410	COG0848	biopolymer transport protein
K08M4_36510	COG0803	Belongs to the bacterial solute-binding protein 9 family
K08M4_36520	COG1121	(ABC) transporter
K08M4_36530	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K08M4_36530	COG1321	iron dependent repressor
K08M4_36570	COG0534	Mate efflux family protein
K08M4_36640	COG0318	PFAM AMP-dependent synthetase and ligase
K08M4_36660	COG3118	belongs to the thioredoxin family
K08M4_36670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K08M4_36720	COG1328	CTP reductase activity
K08M4_36730	COG0602	queuosine metabolic process
K08M4_36740	COG0534	Mate efflux family protein
K08M4_36770	COG0189	ligase activity
K08M4_36770	COG4067	protein conserved in archaea
K08M4_36780	COG0488	(ABC) transporter
K08M4_36840	COG0725	ABC transporter, periplasmic molybdate-binding protein
K08M4_36850	COG4149	molybdate abc transporter
K08M4_36880	COG5001	Diguanylate cyclase
K08M4_36880	COG2203	Gaf domain
K08M4_36880	COG4251	negative regulation of phosphorylation
K08M4_36880	COG3706	GGDEF domain
K08M4_36900	COG3706	GGDEF domain
K08M4_36930	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K08M4_36940	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K08M4_36990	COG3140	Belongs to the UPF0181 family
K08M4_37000	COG3706	GGDEF domain
K08M4_37020	COG2801	Transposase and inactivated derivatives
K08M4_37030	COG0023	Translation Initiation Factor
K08M4_37070	COG3266	domain, Protein
K08M4_37080	COG0045	succinate-CoA ligase (ADP-forming) activity
K08M4_37080	COG1042	CoA-binding domain protein
K08M4_37080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K08M4_37090	COG0583	DNA-binding transcription factor activity
K08M4_37100	COG1629	transport
K08M4_37100	COG4771	TonB-dependent receptor
K08M4_37130	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K08M4_37140	COG1984	allophanate hydrolase subunit 2
K08M4_37160	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K08M4_37170	COG4181	ATPase activity
K08M4_37190	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K08M4_37200	COG1716	ATPase activity
K08M4_37200	COG5001	Diguanylate cyclase
K08M4_37220	COG0768	penicillin binding
K08M4_37230	COG0484	heat shock protein binding
K08M4_37270	COG4533	DNA binding
K08M4_37290	COG2050	protein possibly involved in aromatic compounds catabolism
K08M4_37300	COG0501	Belongs to the peptidase M48B family
K08M4_37320	COG2067	long-chain fatty acid transport protein
K08M4_37330	COG2267	carboxylic ester hydrolase activity
K08M4_37360	COG0583	DNA-binding transcription factor activity
K08M4_37390	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K08M4_37410	COG2985	domain, Protein
K08M4_37450	COG1566	PFAM secretion protein HlyD family protein
K08M4_37490	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K08M4_37510	COG0513	Belongs to the DEAD box helicase family
K08M4_37540	COG0861	Integral membrane protein TerC family
K08M4_37560	COG0737	Belongs to the 5'-nucleotidase family
K08M4_37570	COG3593	DNA synthesis involved in DNA repair
K08M4_37590	COG0583	DNA-binding transcription factor activity
K08M4_37600	COG2116	formate transmembrane transporter activity
K08M4_37620	COG3038	cytochrome b561
K08M4_37650	COG2200	EAL domain
K08M4_37710	COG0513	Belongs to the DEAD box helicase family
K08M4_37740	COG0814	amino acid
K08M4_37750	COG0840	transmembrane signaling receptor activity
K08M4_37760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K08M4_37770	COG3437	response regulator, receiver
K08M4_37770	COG0784	Response regulator, receiver
K08M4_37800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K08M4_37820	COG3706	GGDEF domain
K08M4_37830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K08M4_37960	COG2184	nucleotidyltransferase activity
K08M4_37990	COG4974	Belongs to the 'phage' integrase family
K08M4_38020	COG0517	IMP dehydrogenase activity
K08M4_38040	COG0534	Mate efflux family protein
K08M4_38050	COG1280	lysine exporter protein (LysE YggA)
K08M4_38120	COG2807	transmembrane transport
K08M4_38130	COG5002	protein histidine kinase activity
K08M4_38260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K08M4_38280	COG1538	Outer membrane efflux protein
K08M4_38290	COG1132	(ABC) transporter
K08M4_38360	COG0641	radical SAM
K08M4_38390	COG0583	DNA-binding transcription factor activity
K08M4_38450	COG0714	Associated with various cellular activities
K08M4_38470	COG3119	arylsulfatase activity
K08M4_38480	COG3119	arylsulfatase activity
K08M4_38500	COG0456	acetyltransferase
K08M4_38510	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K08M4_38540	COG0384	phenazine biosynthesis protein PhzF
K08M4_38550	COG1280	lysine exporter protein (LysE YggA)
K08M4_38570	COG3300	MHYT domain
K08M4_38570	COG5001	Diguanylate cyclase
K08M4_38610	COG3278	Belongs to the heme-copper respiratory oxidase family
K08M4_38680	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K08M4_38700	COG1012	belongs to the aldehyde dehydrogenase family
K08M4_38720	COG0583	DNA-binding transcription factor activity
K08M4_38740	COG4172	Belongs to the ABC transporter superfamily
K08M4_38750	COG4239	(ABC) transporter, permease
K08M4_38760	COG4174	ABC transporter (Permease)
K08M4_38770	COG4166	transmembrane transport
K08M4_38800	COG1869	D-ribose catabolic process
K08M4_38810	COG1129	ABC transporter
K08M4_38820	COG1172	Belongs to the binding-protein-dependent transport system permease family
K08M4_38830	COG1879	ABC-type sugar transport system periplasmic component
K08M4_38840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K08M4_38850	COG1609	Transcriptional regulator
K08M4_38910	COG0330	HflC and HflK could
K08M4_38960	COG0243	molybdopterin cofactor binding
K08M4_38970	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K08M4_38990	COG2223	nitrite transmembrane transporter activity
K08M4_39000	COG0515	serine threonine protein kinase
K08M4_39000	COG2815	serine threonine protein kinase
K08M4_39010	COG1609	Transcriptional regulator
K08M4_39020	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K08M4_39020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K08M4_39030	COG1105	Belongs to the carbohydrate kinase PfkB family
K08M4_39040	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K08M4_39040	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K08M4_39040	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
K08M4_39060	COG0625	glutathione transferase activity
K08M4_39070	COG1403	HNH endonuclease
K08M4_39150	COG1879	ABC-type sugar transport system periplasmic component
K08M4_39180	COG0210	DNA helicase
K08M4_39190	COG1289	transmembrane transporter activity
K08M4_39230	COG0583	DNA-binding transcription factor activity
K08M4_39240	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K08M4_39250	COG1328	CTP reductase activity
K08M4_39260	COG3385	transposase activity
K08M4_39270	COG2814	Major facilitator Superfamily
K08M4_39280	COG0583	DNA-binding transcription factor activity
K08M4_39290	COG0784	Response regulator, receiver
K08M4_39290	COG2205	protein histidine kinase activity
K08M4_39300	COG3437	response regulator, receiver
K08M4_39310	COG4604	ABC transporter, ATP-binding protein
K08M4_39320	COG4605	iron ion homeostasis
K08M4_39330	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K08M4_39340	COG4607	ABC-type enterochelin transport system periplasmic component
K08M4_39400	COG0628	permease
K08M4_39440	COG3706	GGDEF domain
K08M4_39460	COG0583	DNA-binding transcription factor activity
K08M4_39510	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K08M4_39520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K08M4_39530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K08M4_39540	COG1116	anion transmembrane transporter activity
K08M4_39550	COG0351	phosphomethylpyrimidine kinase
K08M4_39560	COG0697	spore germination
K08M4_39630	COG2199	diguanylate cyclase activity
K08M4_39630	COG2203	Gaf domain
K08M4_39640	COG3344	reverse transcriptase
K08M4_39660	COG3335	DDE superfamily endonuclease
K08M4_39730	COG3646	Phage regulatory protein
K08M4_39980	COG4695	Portal protein
K08M4_40160	COG0582	viral genome integration into host DNA
K08M4_40190	COG4566	intracellular signal transduction
K08M4_40210	COG0534	Mate efflux family protein
K08M4_40220	COG0583	DNA-binding transcription factor activity
K08M4_40270	COG0604	alcohol dehydrogenase
K08M4_40300	COG1120	ATPase activity
K08M4_40310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K08M4_40320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K08M4_40330	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K08M4_40340	COG4772	TonB-dependent receptor
K08M4_40370	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K08M4_40380	COG0513	Belongs to the DEAD box helicase family
K08M4_40420	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K08M4_40510	COG0667	Aldo Keto reductase
K08M4_40520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K08M4_40530	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K08M4_40540	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
K08M4_40570	COG0513	Belongs to the DEAD box helicase family
K08M4_40590	COG2176	DNA-directed DNA polymerase activity
K08M4_40620	COG0513	Belongs to the DEAD box helicase family
K08M4_40630	COG4989	oxidoreductase activity
K08M4_40680	COG0668	transmembrane transport
K08M4_40700	COG4232	protein-disulfide reductase activity
K08M4_40710	COG3118	belongs to the thioredoxin family
K08M4_40720	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K08M4_40730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K08M4_40740	COG2205	protein histidine kinase activity
K08M4_40750	COG0745	RESPONSE REGULATOR receiver
K08M4_40770	COG5001	Diguanylate cyclase
K08M4_40790	COG1131	(ABC) transporter
K08M4_40840	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K08M4_40840	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K08M4_40860	COG0564	pseudouridine synthase activity
K08M4_40920	COG0747	negative chemotaxis
K08M4_40940	COG0189	ligase activity
K08M4_40940	COG4067	protein conserved in archaea
K08M4_40980	COG1175	transmembrane transport
K08M4_40990	COG0395	ABC-type sugar transport system, permease component
K08M4_41000	COG3842	ATPase activity
K08M4_41010	COG0584	glycerophosphoryl diester phosphodiesterase
K08M4_41060	COG0673	inositol 2-dehydrogenase activity
K08M4_41080	COG2999	glutathione oxidoreductase activity
K08M4_41130	COG0534	Mate efflux family protein
K08M4_41140	COG2964	Protein conserved in bacteria
K08M4_41170	COG0446	pyridine nucleotide-disulphide oxidoreductase
K08M4_41220	COG3335	DDE superfamily endonuclease
K08M4_41350	COG1215	transferase activity, transferring glycosyl groups
K08M4_41390	COG1595	DNA-templated transcription, initiation
K08M4_41400	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K08M4_41430	COG0840	transmembrane signaling receptor activity
K08M4_41460	COG4166	transmembrane transport
K08M4_41470	COG0601	transmembrane transport
K08M4_41480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K08M4_41490	COG4172	Belongs to the ABC transporter superfamily
K08M4_41520	COG0583	DNA-binding transcription factor activity
K08M4_41530	COG4221	oxidoreductase activity
K08M4_41560	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K08M4_41590	COG3639	organic phosphonate transmembrane transporter activity
K08M4_41600	COG3639	organic phosphonate transmembrane transporter activity
K08M4_41610	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
K08M4_41690	COG4948	Mandelate Racemase Muconate Lactonizing
K08M4_41710	COG0583	DNA-binding transcription factor activity
K08M4_41730	COG0366	Alpha amylase catalytic
K08M4_41760	COG0583	DNA-binding transcription factor activity
K08M4_41800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K08M4_41810	COG0814	amino acid
K08M4_41820	COG1846	Transcriptional regulator
K08M4_41830	COG1764	response to oxidative stress
K08M4_41840	COG0840	transmembrane signaling receptor activity
K08M4_41860	COG1309	transcriptional regulator
K08M4_41870	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K08M4_41880	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K08M4_41900	COG2207	Transcriptional regulator
K08M4_41910	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K08M4_41910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K08M4_41910	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K08M4_41940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K08M4_41950	COG4166	transmembrane transport
K08M4_41980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K08M4_41990	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K08M4_42000	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
K08M4_42030	COG1012	belongs to the aldehyde dehydrogenase family
K08M4_42040	COG3284	Transcriptional regulator
K08M4_42050	COG0840	transmembrane signaling receptor activity
K08M4_42060	COG0583	DNA-binding transcription factor activity
K08M4_42070	COG0625	glutathione transferase activity
K08M4_42140	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K08M4_42150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K08M4_42160	COG1418	mRNA catabolic process
K08M4_42250	COG1846	Transcriptional regulator
K08M4_42260	COG0697	spore germination
K08M4_42320	COG1067	ATP-dependent peptidase activity
K08M4_42340	COG4172	Belongs to the ABC transporter superfamily
K08M4_42370	COG1609	Transcriptional regulator
K08M4_42390	COG2017	converts alpha-aldose to the beta-anomer
K08M4_42400	COG3459	Glycosyltransferase 36 associated
K08M4_42410	COG3842	ATPase activity
K08M4_42420	COG2723	6-phospho-beta-galactosidase activity
K08M4_42430	COG0395	ABC-type sugar transport system, permease component
K08M4_42460	COG1609	Transcriptional regulator
K08M4_42480	COG1505	serine-type exopeptidase activity
K08M4_42490	COG0583	DNA-binding transcription factor activity
K08M4_42500	COG1620	l-lactate permease
K08M4_42510	COG1304	FMN binding
K08M4_42540	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K08M4_42540	COG2207	Transcriptional regulator
K08M4_42550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K08M4_42590	COG1482	cell wall glycoprotein biosynthetic process
K08M4_42600	COG2271	Major facilitator Superfamily
K08M4_42610	COG3851	Histidine kinase
K08M4_42620	COG2197	response regulator
K08M4_42680	COG1741	Belongs to the pirin family
K08M4_42720	COG0596	Alpha beta hydrolase
K08M4_42800	COG3788	relative of glutathione S-transferase, MAPEG superfamily
K08M4_42810	COG0700	Nucleoside recognition
K08M4_42820	COG3366	ferrous iron transmembrane transporter activity
K08M4_42830	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K08M4_42850	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K08M4_42860	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K08M4_42950	COG0446	pyridine nucleotide-disulphide oxidoreductase
K08M4_42960	COG0786	glutamate:sodium symporter activity
K08M4_43010	COG1595	DNA-templated transcription, initiation
K08M4_43020	COG3806	Anti-sigma factor
K08M4_43040	COG0415	Belongs to the DNA photolyase family
K08M4_43090	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K08M4_43140	COG0724	RNA recognition motif
K08M4_43180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K08M4_43180	COG1263	PTS System
K08M4_43230	COG1028	Short-chain dehydrogenase reductase Sdr
K08M4_43240	COG2814	Major facilitator Superfamily
K08M4_43250	COG1902	pentaerythritol trinitrate reductase activity
K08M4_43280	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K08M4_43290	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K08M4_43310	COG0612	Peptidase, M16
K08M4_43320	COG0612	Peptidase, M16
K08M4_43330	COG3279	Response regulator of the LytR AlgR family
K08M4_43340	COG3275	phosphorelay sensor kinase activity
K08M4_43370	COG4591	ABC-type transport system involved in lipoprotein release permease component
K08M4_43410	COG0583	DNA-binding transcription factor activity
K08M4_43460	COG2084	Dehydrogenase
K08M4_43500	COG3186	Phenylalanine-4-hydroxylase
K08M4_43510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K08M4_43530	COG0625	glutathione transferase activity
K08M4_43550	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K08M4_43610	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K08M4_43610	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
K08M4_43630	COG0444	Belongs to the ABC transporter superfamily
K08M4_43640	COG4608	Belongs to the ABC transporter superfamily