locus-tag class description K09K1_00020 ENOG4105MQ5 zona occludens toxin K09K1_00140 ENOG4105MQ5 zona occludens toxin K09K1_00260 ENOG4105MQ5 zona occludens toxin K09K1_00360 ENOG4108ZJT translation initiation factor, Sui1 K09K1_00380 ENOG4105CPF Cell wall formation (By similarity) K09K1_00400 ENOG4105CD5 CoA-binding domain protein K09K1_00410 ENOG4105CWB LysR family transcriptional Regulator K09K1_00430 ENOG4105CMR udp-glucose 4-epimerase K09K1_00440 ENOG4105BZU Histidine kinase K09K1_00450 ENOG4105E7W lamb ycsf family protein K09K1_00460 ENOG4105P4J Allophanate hydrolase, subunit 1 K09K1_00470 ENOG4107R7A Allophanate hydrolase subunit 2 K09K1_00490 ENOG4105CV6 ABC transporter, permease K09K1_00500 ENOG4108I0Y (ABC) transporter K09K1_00520 ENOG4105RKW reductase (By K09K1_00530 ENOG4105BZU Histidine kinase K09K1_00600 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) K09K1_00620 ENOG4105KA0 thioesterase Superfamily protein K09K1_00650 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation K09K1_00660 ENOG4108M0H Extracellular lipase K09K1_00700 ENOG4105DU1 integral membrane protein, terc K09K1_00710 ENOG4105CGH 5'-nucleotidase K09K1_00720 ENOG4105CPB ATP-dependent endonuclease of the OLD family K09K1_00730 ENOG4108UQ5 membrane protein YcdZ K09K1_00740 ENOG4105DUM transcriptional regulator, lysR family K09K1_00760 ENOG4105TMB Formate nitrite transporter K09K1_00770 ENOG4108YYC ycei family K09K1_00780 ENOG4105DS1 cytochrome b561 K09K1_00820 ENOG4105C1J atp-dependent rna helicase K09K1_00830 ENOG4108ZYK Acyl carrier protein phosphodiesterase K09K1_00850 ENOG4108N3W hemolysin secretion protein K09K1_00860 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) K09K1_00890 ENOG4107RE1 Inosine-guanosine kinase K09K1_00900 ENOG4105CKU formyltetrahydrofolate synthetase K09K1_00910 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) K09K1_00930 ENOG4105CF7 AraC family transcriptional regulator K09K1_00940 ENOG4108I6A alcohol dehydrogenase K09K1_00960 ENOG4105CDA abc transporter atp-binding protein K09K1_00970 ENOG4105E5Q amino acid AbC transporter K09K1_00980 ENOG4106TNF Periplasmic binding protein K09K1_00990 ENOG4105DRP amino acid AbC transporter K09K1_01000 ENOG4108NJZ Sensory box GGDEF EAL domain protein K09K1_01030 ENOG4107B7Y DNA-binding transcriptional regulator FruR K09K1_01040 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein K09K1_01050 ENOG4105DE4 1-phosphofructokinase K09K1_01060 ENOG4105DM4 PTS System K09K1_01120 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) K09K1_01140 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) K09K1_01150 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) K09K1_01160 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K09K1_01170 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase K09K1_01180 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) K09K1_01190 ENOG4105EJC lysr family transcriptional regulator K09K1_01200 ENOG4108IPJ Membrane K09K1_01210 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) K09K1_01270 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) K09K1_01350 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) K09K1_01410 ENOG4105CJW magnesium transporter K09K1_01450 ENOG4108UYE Lactoylglutathione lyase K09K1_01460 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase K09K1_01480 ENOG4105EXC Acyl-transferase K09K1_01510 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) K09K1_01520 ENOG4105CBC glutamate synthase K09K1_01540 ENOG4107RGH Aldehyde dehydrogenase K09K1_01570 ENOG4108I0N Transporter, RarD family, DMT superfamily protein K09K1_01620 ENOG4105FR1 rard protein K09K1_01640 ENOG4108VAU general secretion pathway protein G K09K1_01650 ENOG4107R88 Chemotaxis protein (CheV) K09K1_01660 ENOG4108WQH regulatoR K09K1_01680 ENOG4105BZU Histidine kinase K09K1_01690 ENOG4105WH1 Two component transcriptional regulator luxr family K09K1_01700 ENOG4105BZU Histidine kinase K09K1_01710 ENOG4105BZU Histidine kinase K09K1_01720 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) K09K1_01730 ENOG4107KBT 8-Amino-7-oxononanoate synthase K09K1_01740 ENOG4108MGY Histidine kinase K09K1_01780 ENOG4105CEE C4-dicarboxylate transporter K09K1_01810 ENOG4105F2V VRR-NUC domain-containing protein K09K1_01830 ENOG4108YDI single-species biofilm formation on inanimate substrate K09K1_01840 ENOG4107TE5 Lipid kinase K09K1_01850 ENOG41064T2 transcriptional regulator, lysR family K09K1_01860 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) K09K1_01920 ENOG4105C7R Atpase associated with various cellular activities aaa_3 K09K1_01930 ENOG4105C4X radical SAM domain protein K09K1_01940 ENOG41061MV Arylsulfatase K09K1_01960 ENOG4105ENH Sulfatase K09K1_01970 ENOG4105E3W Two component transcriptional regulator (Winged helix family K09K1_02000 ENOG4105BZU Histidine kinase K09K1_02010 ENOG4108SV3 Tmao reductase system periplasmic protein tort K09K1_02020 ENOG4108Z5K methylglyoxal synthase K09K1_02030 ENOG41088T4 Helicase IV K09K1_02040 ENOG4105EM2 membrane K09K1_02130 ENOG4108Z6Z Transcriptional regulator K09K1_02140 ENOG4108IPW abc transporter atp-binding protein K09K1_02150 ENOG4105CM4 permease protein K09K1_02160 ENOG4105DHS permease protein K09K1_02190 ENOG4108I5U Uridine phosphorylase K09K1_02200 ENOG4106Z1T Nicotinamide Mononucleotide Transporter K09K1_02220 ENOG4105ETE Transcriptional regulator (LacI family K09K1_02230 ENOG4108RVA ribokinase K09K1_02240 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator K09K1_02250 ENOG4105CNN ABC, transporter K09K1_02260 ENOG4105C2J ABC transporter K09K1_02270 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) K09K1_02280 ENOG4108K0B C-di-gmp phosphodiesterase K09K1_02380 ENOG4105D82 Glutamate dehydrogenase K09K1_02400 ENOG4105BZU Histidine kinase K09K1_02410 ENOG4105CA0 peroxidase K09K1_02430 ENOG4107QX8 SPFH domain, Band 7 family protein K09K1_02450 ENOG4108RCM Nitroreductase K09K1_02460 ENOG4108IJ7 Glycine betaine K09K1_02470 ENOG4108HQS Glycine betaine K09K1_02490 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) K09K1_02500 ENOG4105C26 Dehydrogenase K09K1_02510 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) K09K1_02520 ENOG4105BZU Histidine kinase K09K1_02540 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase K09K1_02560 ENOG4105E39 Enoyl-CoA hydratase K09K1_02570 ENOG4105C1G acyl-Coa dehydrogenase K09K1_02580 ENOG4105C26 Dehydrogenase K09K1_02590 ENOG4105CHU acetyl-coa acetyltransferase K09K1_02610 ENOG4105C1G acyl-Coa dehydrogenase K09K1_02620 ENOG4107QX3 carboxylase K09K1_02630 ENOG4108IPT Naphthoate synthase K09K1_02650 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase K09K1_02670 ENOG4105EGS Mechanosensitive ion channel K09K1_02680 ENOG4108UW5 maltose o-acetyltransferase K09K1_02690 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family K09K1_02700 ENOG4105C4M (Ubiquinol oxidase) subunit I K09K1_02710 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii K09K1_02730 ENOG4108S58 Phenazine biosynthesis protein PhzF K09K1_02770 ENOG4107FQX Alpha-acetolactate decarboxylase K09K1_02780 ENOG4105C7K acetolactate synthase K09K1_02800 ENOG4105FQ6 thiopurine methyltransferase K09K1_02810 ENOG4105DZS Phenylacetate-CoA ligase K09K1_02820 ENOG4108IV0 ABC, transporter K09K1_02860 ENOG4108IQE Amp-dependent synthetase and ligase K09K1_02870 ENOG4105C0Z ABC transporter K09K1_02880 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase K09K1_02890 ENOG4105BZJ Electron transfer flavoprotein K09K1_02900 ENOG4105C10 Electron transfer flavoprotein K09K1_02910 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) K09K1_02920 ENOG4105CI1 PTS System K09K1_02930 ENOG4105F8D glycoside hydrolase family 4 K09K1_02940 ENOG4105FDP GntR family transcriptional regulator K09K1_02950 ENOG4105KJM monovalent cation h antiporter subunit g K09K1_02960 ENOG41080TA Multiple resistance and ph regulation protein f K09K1_02970 ENOG4105SC1 monovalent cation H antiporter subunit E K09K1_02980 ENOG4108JPZ Monovalent cation H antiporter subunit D K09K1_02990 ENOG4108ZE9 Monovalent cation H antiporter subunit C K09K1_03000 ENOG4105D65 subunit l K09K1_03020 ENOG4105Q9Y Universal stress protein K09K1_03030 ENOG4105EMU Dehydrogenase K09K1_03040 ENOG4105HEI LysR family (Transcriptional regulator K09K1_03060 ENOG4105C2C drug resistance transporter, Bcr CflA K09K1_03190 ENOG4105EW9 transcriptional regulator AsnC family K09K1_03260 ENOG4105D9P serine threonine protein kinase K09K1_03310 ENOG4105CS6 Rhs element vgr protein K09K1_03320 ENOG4108WC9 type VI secretion system effector, hcp1 family K09K1_03330 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit K09K1_03340 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family K09K1_03400 ENOG4105DR5 peptidase K09K1_03430 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family K09K1_03530 ENOG4107QHE Choloylglycine hydrolase K09K1_03540 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) K09K1_03550 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) K09K1_03580 ENOG4107RGM aldo keto reductase K09K1_03610 ENOG4105CMQ Chloride channel K09K1_03630 ENOG4105EUJ GTP cyclohydrolase i K09K1_03640 ENOG4105CVM Molybdenum cofactor synthesis domain protein K09K1_03650 ENOG4105D06 uba thif-type nad fad binding protein K09K1_03680 ENOG4105KHC sulfurtransferase K09K1_03700 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) K09K1_03710 ENOG4105CV1 Transketolase (EC 2.2.1.1) K09K1_03720 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor K09K1_03730 ENOG4105DXI Major Facilitator superfamily K09K1_03740 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) K09K1_03750 ENOG4105UYK outer membrane protein a K09K1_03760 ENOG4107VXZ Hydrolase K09K1_03770 ENOG4108YZN class I peptide chain release factor K09K1_03780 ENOG4108N3W hemolysin secretion protein K09K1_03820 ENOG4107YWA deoxycytidylate deaminase K09K1_03830 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) K09K1_03860 ENOG4105WH1 Two component transcriptional regulator luxr family K09K1_03870 ENOG4105BZU Histidine kinase K09K1_03900 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) K09K1_03940 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class K09K1_03960 ENOG4105CHU acetyl-coa acetyltransferase K09K1_04000 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) K09K1_04010 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) K09K1_04060 ENOG4105EW9 transcriptional regulator AsnC family K09K1_04100 ENOG4105J12 Multidrug resistance protein mdtN K09K1_04110 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) K09K1_04120 ENOG4105BZU Histidine kinase K09K1_04130 ENOG4108QGH periplasmic K09K1_04140 ENOG41082IR Excinuclease ABC C subunit domain protein K09K1_04150 ENOG4108YXG UPF0502 protein K09K1_04170 ENOG41090HJ UPF0265 protein K09K1_04190 ENOG4105BZU Histidine kinase K09K1_04250 ENOG4105DUM transcriptional regulator, lysR family K09K1_04270 ENOG4105DVH amino acid K09K1_04300 ENOG4105E0F Histidine kinase K09K1_04310 ENOG4105CK6 Two component transcriptional regulator (Winged helix family K09K1_04360 ENOG4105J12 Multidrug resistance protein mdtN K09K1_04370 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) K09K1_04380 ENOG4105CJW magnesium transporter K09K1_04390 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin K09K1_04400 ENOG4105DZC cytosine deaminase K09K1_04410 ENOG4105EST Metal Dependent Phosphohydrolase K09K1_04430 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) K09K1_04450 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) K09K1_04490 ENOG4108Z33 Thiol disulfide Interchange Protein K09K1_04520 ENOG4107EXC regulatoR K09K1_04530 ENOG4105E0F Histidine kinase K09K1_04550 ENOG41080IJ Diacylglycerol kinase K09K1_04560 ENOG4105DIJ Phosphoethanolamine transferase K09K1_04570 ENOG4105EP9 oxidoreductase K09K1_04600 ENOG4108NRW Phospholipase, patatin family K09K1_04610 ENOG4105EUB pirin domain protein K09K1_04620 ENOG4105VEQ Cold shock protein K09K1_04650 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) K09K1_04660 ENOG4105EHV domain protein K09K1_04680 ENOG4105DZ1 carboxypeptidase K09K1_04700 ENOG4105CYM Glutathione S-transferase K09K1_04710 ENOG4108HKT sucrose-6-phosphate hydrolase K09K1_04720 ENOG4105D7K pfkb domain protein K09K1_04730 ENOG4105C5Y PTS System K09K1_04770 ENOG4105CHR reductase K09K1_04800 ENOG4108P3C K09K1_04830 ENOG4105E1F short-chain dehydrogenase reductase K09K1_04840 ENOG4105HEI LysR family (Transcriptional regulator K09K1_04850 ENOG410874W AraC family transcriptional regulator K09K1_04860 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family K09K1_04900 ENOG4105C1J atp-dependent rna helicase K09K1_04920 ENOG4107RSM transcriptional regulator K09K1_04950 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase K09K1_04960 ENOG4105CPQ Dehydrogenase K09K1_04980 ENOG4105CHR reductase K09K1_05000 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family K09K1_05010 ENOG4105ENR peptidase, M24 K09K1_05020 ENOG4105E5N succinylglutamate desuccinylase aspartoacylase K09K1_05030 ENOG4108RYR transcriptional regulator AsnC family K09K1_05040 ENOG4105C26 Dehydrogenase K09K1_05050 ENOG4105C8Y Acetylornithine aminotransferase K09K1_05060 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme K09K1_05100 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis K09K1_05110 ENOG4105HDK L-asparaginase K09K1_05120 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) K09K1_05150 ENOG4105WH1 Two component transcriptional regulator luxr family K09K1_05160 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) K09K1_05170 ENOG4107RUE extracellular solute-binding protein family 1 K09K1_05270 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) K09K1_05310 ENOG4105BZS acriflavin resistance protein K09K1_05370 ENOG4107RZC phospholipase d K09K1_05420 ENOG4108Z4X TRANSCRIPTIONal K09K1_05440 ENOG4105RQF LysR family Transcriptional regulator K09K1_05460 ENOG4107S8C mandelate racemase muconate lactonizing K09K1_05470 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) K09K1_05520 ENOG4105VYW UPF0251 protein K09K1_05530 ENOG4107U14 binding-protein-dependent transport systems inner membrane Component K09K1_05540 ENOG4108IJ7 Glycine betaine K09K1_05550 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion K09K1_05560 ENOG4105RW8 MltA-interacting MipA family protein K09K1_05590 ENOG4105ETT transcriptional Regulator, LysR family K09K1_05640 ENOG4107RH7 Nicotinate phosphoribosyltransferase K09K1_05660 ENOG4108RWI nicotinamidase K09K1_05690 ENOG4105N2W Transcriptional regulator K09K1_05700 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) K09K1_05710 ENOG4105EA8 2-Nitropropane dioxygenase K09K1_05720 ENOG4105CUB amino acid K09K1_05730 ENOG4107FQ9 ethanolamine ammonia-lyase K09K1_05740 ENOG4105CPD ethanolamine ammonia-lyase K09K1_05750 ENOG4108K3Z AraC family transcriptional regulator K09K1_05760 ENOG4107Z3H Transcriptional regulator, TetR family K09K1_05800 ENOG4105N14 lysine exporter protein LysE YggA K09K1_05820 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) K09K1_05830 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) K09K1_05840 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) K09K1_05870 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) K09K1_05910 ENOG4105DTJ flagellar hook-associated protein K09K1_05920 ENOG4105E1Q flagellar hook-associated protein K09K1_05930 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj K09K1_05940 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) K09K1_05950 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) K09K1_05960 ENOG4105CGA flagellar basal-body rod protein FlgG K09K1_05970 ENOG4108KPB Flagellar basal-body rod protein FlgF K09K1_05980 ENOG4105BZE flagellar hook protein, FlgE K09K1_05990 ENOG4105W00 Flagellar hook capping protein K09K1_06000 ENOG4108ZC9 flagellar basal-body rod protein flgc K09K1_06010 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) K09K1_06050 ENOG4105E4C Lytic transglycosylase catalytic K09K1_06060 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) K09K1_06100 ENOG4105EJQ L-serine dehydratase K09K1_06130 ENOG4105ETT transcriptional Regulator, LysR family K09K1_06140 ENOG4105UYK outer membrane protein a K09K1_06160 ENOG4105CJP fad dependent oxidoreductase K09K1_06180 ENOG4108MJ5 VirK protein K09K1_06220 ENOG4107RCV ABC transporter, permease K09K1_06260 ENOG4107STF Involved in phosphonate degradation (By similarity) K09K1_06270 ENOG4108JPW Aminotransferase K09K1_06280 ENOG4108KAZ Involved in phosphonate degradation (By similarity) K09K1_06290 ENOG4105ETE Transcriptional regulator (LacI family K09K1_06340 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin K09K1_06350 ENOG4105KUU lipolytic protein G-D-S-L family K09K1_06360 ENOG4105MKU Transcriptional regulator K09K1_06390 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) K09K1_06400 ENOG4105DJY efflux transporter, rnd family, mfp subunit K09K1_06410 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation K09K1_06420 ENOG4108UHE carbonic anhydrase K09K1_06430 ENOG4108UUE Transcriptional regulator K09K1_06460 ENOG4105PAD Hydrolase K09K1_06470 ENOG4105JQN Transcriptional regulator K09K1_06530 ENOG4108UW5 maltose o-acetyltransferase K09K1_06540 ENOG4108UKZ OsmC family K09K1_06550 ENOG4105E0X reductase K09K1_06570 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein K09K1_06580 ENOG4105CVP deoxyribo-dipyrimidine photolyase K09K1_06590 ENOG4106TD9 Diguanylate cyclase K09K1_06620 ENOG4105BZU Histidine kinase K09K1_06650 ENOG4105D9N nucleoside K09K1_06680 ENOG4105C0F tryptophanase EC 4.1.99.1 K09K1_06700 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) K09K1_06710 ENOG4105C4M (Ubiquinol oxidase) subunit I K09K1_06720 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii K09K1_06750 ENOG4105NVB glycoside hydrolase, family 19 K09K1_06760 ENOG4105D5U fad dependent oxidoreductase K09K1_06800 ENOG4105CWM branched-chain amino acid transport system II carrier protein K09K1_06810 ENOG4105BZU Histidine kinase K09K1_06820 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family K09K1_06870 ENOG4105DUM transcriptional regulator, lysR family K09K1_06910 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) K09K1_06920 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) K09K1_06940 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) K09K1_06950 ENOG4105CYW agmatinase K09K1_06960 ENOG4105E5M Multidrug resistance protein D K09K1_06970 ENOG4105CUG Oligopeptidase b K09K1_07000 ENOG4105CC5 ABC transporter K09K1_07010 ENOG4105DIK (ABC) transporter K09K1_07020 ENOG4105DSE periplasmic solute binding protein K09K1_07100 ENOG4109015 Biopolymer transport protein exbD tolR K09K1_07150 ENOG410804D Sensor Signal Transduction Histidine Kinase K09K1_07160 ENOG4105E3W Two component transcriptional regulator (Winged helix family K09K1_07170 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase K09K1_07190 ENOG4105C5I Dehydrogenase K09K1_07200 ENOG4108YYI Protein of unknown function (DUF2810) K09K1_07310 ENOG4108TEM pseudouridine methyltransferase K09K1_07340 ENOG4105DWF phosphomethylpyrimidine kinase K09K1_07350 ENOG4108YI8 ABC transporter K09K1_07360 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component K09K1_07370 ENOG4107Z6I Thiamine biosynthesis protein K09K1_07380 ENOG4105ETU transcriptional activator (TenA K09K1_07390 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase K09K1_07400 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) K09K1_07420 ENOG4107QY8 reductase K09K1_07430 ENOG4105CUW cytochrome C-TYPE protein K09K1_07440 ENOG41068WN K09K1_07450 ENOG4105CYX Short-chain dehydrogenase reductase Sdr K09K1_07520 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family K09K1_07530 ENOG4105BZW Glycerate kinase K09K1_07540 ENOG4105C6Z Gluconate K09K1_07550 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR K09K1_07620 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase K09K1_07660 ENOG4105C0R drug resistance transporter emrb qaca subfamily K09K1_07680 ENOG4105EIF outer membrane protein W K09K1_07700 ENOG4107W31 Pentapeptide repeat protein K09K1_07740 ENOG4105EW9 transcriptional regulator AsnC family K09K1_07760 ENOG4105Q26 Siderophore-interacting protein K09K1_07770 ENOG4105CC0 LysR family Transcriptional regulator K09K1_07780 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase K09K1_07800 ENOG4105C4W S-formylglutathione hydrolase K09K1_07840 ENOG4108KHX Diguanylate cyclase K09K1_07860 ENOG4108HCJ Hydrolase K09K1_07870 ENOG4105EJC lysr family transcriptional regulator K09K1_07900 ENOG4105D3G Pseudouridine synthase K09K1_07910 ENOG4105UQX Mate efflux family protein K09K1_07920 ENOG4108K0B C-di-gmp phosphodiesterase K09K1_07940 ENOG4105NBK UPF0345 protein K09K1_07970 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) K09K1_08010 ENOG4105DN9 Na H antiporter K09K1_08020 ENOG4105DN9 Na H antiporter K09K1_08060 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) K09K1_08070 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) K09K1_08090 ENOG4108VGI doxx family K09K1_08100 ENOG4105C2I pirin domain protein K09K1_08140 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) K09K1_08160 ENOG4105D6U Sodium Glutamate Symporter K09K1_08170 ENOG4107U9B transcriptional regulator K09K1_08180 ENOG4105CZV ABC transporter K09K1_08200 ENOG4105D6U Sodium Glutamate Symporter K09K1_08230 ENOG4105C8Q Methyl-accepting chemotaxis K09K1_08240 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) K09K1_08260 ENOG4108VAC response regulator K09K1_08270 ENOG4108HRK Histidine kinase K09K1_08330 ENOG4105CNI cell division protein FtsW K09K1_08340 ENOG4105CDY transcriptional regulatory protein K09K1_08360 ENOG4105BZU Histidine kinase K09K1_08410 ENOG4108JQ7 (ABC) transporter K09K1_08460 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) K09K1_08490 ENOG4105EQ2 LysR family Transcriptional regulator K09K1_08500 ENOG4105EC3 peptidase S51, dipeptidase E K09K1_08510 ENOG4105FCK Membrane K09K1_08520 ENOG4105C5Y PTS System K09K1_08530 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K09K1_08540 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) K09K1_08560 ENOG4108J59 Extracellular solute-binding protein, family 5 K09K1_08600 ENOG4108JJA ABC, transporter K09K1_08630 ENOG4107QZV Type I secretion membrane fusion protein K09K1_08640 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family K09K1_08650 ENOG4105CQZ Histidine kinase K09K1_08660 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) K09K1_08690 ENOG4105C26 Dehydrogenase K09K1_08710 ENOG4105CK7 Sodium proline symporter K09K1_08770 ENOG4105EW9 transcriptional regulator AsnC family K09K1_08790 ENOG4105BZ1 (ABC) transporter K09K1_08810 ENOG4105C1J atp-dependent rna helicase K09K1_08820 ENOG4108RPX mosc domain containing protein K09K1_08870 ENOG4105ECQ AraC Family Transcriptional Regulator K09K1_08910 ENOG4108JU3 Alkyl hydroperoxide reductase K09K1_08920 ENOG4105D3R alkyl hydroperoxide reductase K09K1_09010 ENOG4105K56 Transcriptional regulator K09K1_09020 ENOG4108ZHJ Organic hydroperoxide resistance protein K09K1_09100 ENOG4105C19 ABC transporter K09K1_09140 ENOG4105CI1 PTS System K09K1_09150 ENOG4105DPZ Two component transcriptional regulator (Winged helix family K09K1_09160 ENOG4105DHQ Histidine kinase K09K1_09170 ENOG4108JP0 extracellular solute-binding protein family 1 K09K1_09180 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) K09K1_09190 ENOG4105DBM Siderophore biosynthesis protein K09K1_09210 ENOG4105DUU IucA IucC family protein K09K1_09230 ENOG4105E0K tonB-dependent siderophore receptor K09K1_09240 ENOG4105GAV receptor K09K1_09250 ENOG4108HUF Transporter K09K1_09260 ENOG4105DQ5 transport system permease protein K09K1_09270 ENOG4108U1V ABC transporter, permease K09K1_09280 ENOG4105E0A ABC, transporter K09K1_09290 ENOG4105C8Q Methyl-accepting chemotaxis K09K1_09300 ENOG4107RAN Peptidase, M16 K09K1_09320 ENOG4105DR5 peptidase K09K1_09350 ENOG4105E5M Multidrug resistance protein D K09K1_09370 ENOG4105ETE Transcriptional regulator (LacI family K09K1_09380 ENOG4107RJ1 sodium solute K09K1_09410 ENOG4105CG6 trap dicarboxylate transporter dctm subunit K09K1_09430 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit K09K1_09440 ENOG4105ETE Transcriptional regulator (LacI family K09K1_09450 ENOG4105CNV Aldolase K09K1_09460 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) K09K1_09470 ENOG4105CHR reductase K09K1_09490 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) K09K1_09520 ENOG4105D2S major facilitator superfamily K09K1_09540 ENOG4105EJQ L-serine dehydratase K09K1_09560 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) K09K1_09600 ENOG4108K8S endonuclease I K09K1_09640 ENOG4105CXN decarboxylase K09K1_09650 ENOG4105D5Q Arginine ornithine antiporter K09K1_09670 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) K09K1_09680 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) K09K1_09690 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) K09K1_09740 ENOG41061ZR Transcriptional regulator K09K1_09750 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) K09K1_09760 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) K09K1_09770 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) K09K1_09780 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase K09K1_09790 ENOG4107T9C Alpha amylase catalytic region K09K1_09810 ENOG41074DU domain protein K09K1_09820 ENOG4108P2H Inner membrane protein YjiG K09K1_09830 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) K09K1_09850 ENOG4105CK2 sodium dicarboxylate symporter K09K1_09870 ENOG4105F04 LysR family Transcriptional regulator K09K1_09880 ENOG4105N0V mono-oxygenase ydhR K09K1_09910 ENOG4105KJF protein tyrosine phosphatase K09K1_09920 ENOG4105DAY polysaccharide export protein K09K1_09950 ENOG41081FY multiple antibiotic resistance (MarC)-related K09K1_09960 ENOG4108NRW Phospholipase, patatin family K09K1_09970 ENOG4108M1A Chitin-binding protein K09K1_09990 ENOG4105CVP deoxyribo-dipyrimidine photolyase K09K1_10010 ENOG4105C72 UPF0176 protein K09K1_10030 ENOG4105DZ1 carboxypeptidase K09K1_10050 ENOG4108ZX5 transcriptional regulator K09K1_10060 ENOG4108RCM Nitroreductase K09K1_10080 ENOG4105ETT transcriptional Regulator, LysR family K09K1_10090 ENOG4105VYA Uncharacterized conserved protein (DUF2132) K09K1_10120 ENOG4105DP0 ferredoxin-NADP reductase K09K1_10140 ENOG41068P6 UPF0319 protein K09K1_10150 ENOG4105IPI Membrane K09K1_10200 ENOG4105DSW Fusaric acid resistance protein K09K1_10220 ENOG4105G2Y Transcriptional regulator K09K1_10230 ENOG4105CNH Multidrug resistance protein MdtL K09K1_10250 ENOG4105I4A GCN5-related N-acetyltransferase K09K1_10270 ENOG4105E3W Two component transcriptional regulator (Winged helix family K09K1_10280 ENOG4105EB3 Histidine kinase K09K1_10310 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) K09K1_10320 ENOG4105F1A Pyruvate formate-lyase K09K1_10330 ENOG4105C6N Formate acetyltransferase K09K1_10370 ENOG4105KWG Pfam:DUF1696 K09K1_10400 ENOG4105ER2 Ompa motb domain protein K09K1_10410 ENOG4107RD7 Flagellar Motor Protein, MotA K09K1_10460 ENOG4105MQ3 flagellar protein FliS K09K1_10470 ENOG410804A Flagellar hook-associated 2 domain-containing protein K09K1_10490 ENOG4105I03 Flagellin K09K1_10520 ENOG4105D00 flagellar biosynthetic protein flhB K09K1_10530 ENOG4105D19 Role in flagellar biosynthesis (By similarity) K09K1_10540 ENOG4105VS8 Flagellar biosynthetic protein fliq K09K1_10550 ENOG4105CN7 Flagellar biosynthetic protein FliP K09K1_10560 ENOG4105DD5 Flagellar motor switch protein K09K1_10590 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family K09K1_10610 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) K09K1_10620 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) K09K1_10640 ENOG4108JIR Flagellum-specific ATP synthase K09K1_10700 ENOG4107SSZ Phosphatase K09K1_10730 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase K09K1_10740 ENOG4105EXG Transcriptional regulator K09K1_10780 ENOG4105DPZ Two component transcriptional regulator (Winged helix family K09K1_10800 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) K09K1_10830 ENOG4105BZU Histidine kinase K09K1_10840 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) K09K1_10850 ENOG4105CPQ Dehydrogenase K09K1_10920 ENOG4105D64 Mechanosensitive ion channel K09K1_10940 ENOG4105DMF Dehydrogenase K09K1_10950 ENOG4105DAA L-lactate K09K1_10960 ENOG410642W LysR family Transcriptional regulator K09K1_10980 ENOG4108JQ5 ABC transporter K09K1_11000 ENOG4105DAN ATP-dependent protease K09K1_11020 ENOG4107QE9 Inherit from COG: Membrane K09K1_11030 ENOG4105YE1 PilZ domain K09K1_11060 ENOG4105WCN acetyltransferase K09K1_11070 ENOG4108BGM Quinol dehydrogenase periplasmic component K09K1_11080 ENOG4105GXZ Ferredoxin-type protein NapH K09K1_11120 ENOG4108JJB ABC transporter K09K1_11130 ENOG4108V7D UPF0397 protein K09K1_11140 ENOG4105EFX secretion protein, HlyD family K09K1_11150 ENOG4105KK7 inner membrane protein YiaW K09K1_11160 ENOG4106TD9 Diguanylate cyclase K09K1_11190 ENOG4105D3A purine nucleoside phosphorylase DeoD-type K09K1_11200 ENOG4107SEY Conserved Protein K09K1_11210 ENOG4108XDN Transcriptional regulator K09K1_11220 ENOG4105CVP deoxyribo-dipyrimidine photolyase K09K1_11230 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein K09K1_11250 ENOG4105C1J atp-dependent rna helicase K09K1_11260 ENOG4105CUG Oligopeptidase b K09K1_11270 ENOG4107ENK receptor K09K1_11310 ENOG4108NVR Methyl-accepting chemotaxis K09K1_11320 ENOG4107S17 Phosphate-binding protein K09K1_11330 ENOG4105C8U phosphate abc transporter K09K1_11340 ENOG4105E2Z phosphate ABC transporter (Permease K09K1_11350 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) K09K1_11380 ENOG4107QVM von Willebrand factor, type A K09K1_11420 ENOG4105C7R Atpase associated with various cellular activities aaa_3 K09K1_11430 ENOG4105C8Q Methyl-accepting chemotaxis K09K1_11450 ENOG41086KC Transcriptional regulator K09K1_11460 ENOG41086KC Transcriptional regulator K09K1_11480 ENOG4108JJ6 Type I secretion system ATPase K09K1_11510 ENOG4105S6R Iron-hydroxamate transporter permease subunit K09K1_11520 ENOG4108HUF Transporter K09K1_11530 ENOG4105E0A ABC, transporter K09K1_11540 ENOG4105E0K tonB-dependent siderophore receptor K09K1_11550 ENOG4105BZ1 (ABC) transporter K09K1_11590 ENOG4105CZN Potassium uptake protein K09K1_11600 ENOG4105ETT transcriptional Regulator, LysR family K09K1_11620 ENOG4105DVW rieske (2Fe-2S) K09K1_11630 ENOG4105C26 Dehydrogenase K09K1_11640 ENOG4107QZF nitrite reductase NADPH large subunit K09K1_11650 ENOG4105CJP fad dependent oxidoreductase K09K1_11680 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 K09K1_11740 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase K09K1_11750 ENOG4105CH6 catalase K09K1_11760 ENOG4108RXX maleylacetoacetate isomerase K09K1_11770 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein K09K1_11780 ENOG4108WUH Transcriptional regulator, TetR family K09K1_11790 ENOG4105V0I UPF0267 protein K09K1_11870 ENOG4108F2G Chain length determinant protein K09K1_11900 ENOG4105D3Q Sugar transferase K09K1_11910 ENOG4108IJ9 (ABC) transporter K09K1_11920 ENOG4107FKK extracellular solute-binding protein family 1 K09K1_11930 ENOG4105D56 permease protein K09K1_11940 ENOG4105EG2 ABC transporter, permease K09K1_12000 ENOG4105CKW Inner membrane protein yedI K09K1_12010 ENOG4105EKE dihydroorotase K09K1_12030 ENOG4105QVC MOSC domain-containing protein K09K1_12030 ENOG4105QVC MOSC domain-containing protein K09K1_12040 ENOG4107RA1 nh(3)-dependent nad( ) synthetase K09K1_12050 ENOG4107X4V Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) K09K1_12130 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) K09K1_12140 ENOG4105EHG Permease protein K09K1_12160 ENOG4106GFD transport protein K09K1_12170 ENOG41090AP transport protein K09K1_12180 ENOG4105WQ5 TonB family K09K1_12190 ENOG4105D4P Coproporphyrinogen iii oxidase K09K1_12200 ENOG41090JE Utilization Protein K09K1_12210 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related K09K1_12230 ENOG4107R88 Chemotaxis protein (CheV) K09K1_12240 ENOG4105KQ5 peptidylprolyl cis-trans isomerase K09K1_12250 ENOG4107R73 Mate efflux family protein K09K1_12260 ENOG4105C3U ABC transporter K09K1_12270 ENOG4108JQ7 (ABC) transporter K09K1_12280 ENOG4105DEF Extracellular solute-binding protein, family 5 K09K1_12300 ENOG4105MVE transcriptional regulator K09K1_12310 ENOG4105ZXK Dehydrogenase K09K1_12320 ENOG4105G63 Type III effector Hrp-dependent K09K1_12330 ENOG4105FB2 class II Aldolase K09K1_12340 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) K09K1_12350 ENOG4105EXW epimerase dehydratase K09K1_12360 ENOG4105C6Z Gluconate K09K1_12370 ENOG41090EM Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter K09K1_12380 ENOG41061MD high-affinity nickel-transporter K09K1_12390 ENOG4105C8Q Methyl-accepting chemotaxis K09K1_12400 ENOG4105CR8 Transcriptional regulator K09K1_12430 ENOG4105KXC Collagenase K09K1_12450 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase K09K1_12460 ENOG4105VUF Transcriptional regulator K09K1_12500 ENOG4105CKD glutathione-regulated potassium-efflux system protein K09K1_12510 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein K09K1_12520 ENOG4108M6U Universal stress protein A K09K1_12530 ENOG4105C5H ABC transporter K09K1_12560 ENOG4105ENT Efflux transporter rnd family, mfp subunit K09K1_12580 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation K09K1_12600 ENOG4108HK0 -acetyltransferase K09K1_12650 ENOG4108IJF Heavy metal efflux pump, CzcA K09K1_12690 ENOG4108IEG Formate dehydrogenase Alpha subunit K09K1_12710 ENOG4107QWP ABC-2 type transporter K09K1_12720 ENOG4105CJ1 ABC, transporter K09K1_12780 ENOG4108IA2 Sodium pantothenate symporter K09K1_12790 ENOG4107SS6 2-dehydro-3-deoxygluconokinase K09K1_12800 ENOG4108UHU Aldolase K09K1_12810 ENOG4105E2D ec 3.2.1.52 K09K1_12820 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) K09K1_12830 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) K09K1_12840 ENOG4105JAB phenazine biosynthesis protein, phzf family K09K1_12850 ENOG4108V1U phospholipid-binding protein K09K1_12870 ENOG4105D6J arsenicaL-resistance protein K09K1_12900 ENOG4105KVH Transcriptional regulator K09K1_12950 ENOG4105JQN Transcriptional regulator K09K1_12960 ENOG4107RGM aldo keto reductase K09K1_13010 ENOG4105E0U tyrosine-specific transport protein K09K1_13030 ENOG4105C8Q Methyl-accepting chemotaxis K09K1_13040 ENOG4105DWD nucleoside recognition domain protein K09K1_13080 ENOG4105DR5 peptidase K09K1_13100 ENOG4105CR8 Transcriptional regulator K09K1_13110 ENOG4105E5M Multidrug resistance protein D K09K1_13140 ENOG4105VW4 glutaredoxin 3 K09K1_13150 ENOG4108SXK Transporter Drug Metabolite Exporter family K09K1_13180 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase K09K1_13270 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) K09K1_13320 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) K09K1_13330 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) K09K1_13340 ENOG4108V1T peptidylprolyl cis-trans isomerase K09K1_13360 ENOG4105CDV Ompa motb domain protein K09K1_13400 ENOG4105VEQ Cold shock protein K09K1_13410 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system K09K1_13420 ENOG4105BZU Histidine kinase K09K1_13430 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) K09K1_13450 ENOG4105BZ1 (ABC) transporter K09K1_13460 ENOG4105BZ1 (ABC) transporter K09K1_13470 ENOG4105DFG type I secretion outer membrane protein K09K1_13480 ENOG4108MGY Histidine kinase K09K1_13530 ENOG4105C8Q Methyl-accepting chemotaxis K09K1_13550 ENOG4108RMU ferritin dps family protein K09K1_13580 ENOG4105C0A alcohol dehydrogenase K09K1_13590 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain K09K1_13640 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) K09K1_13650 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) K09K1_13660 ENOG4105MIR Phenylalanine 4-monooxygenase K09K1_13670 ENOG41090A4 Pterin carbinolamine dehydratase K09K1_13710 ENOG4105VRT cytoplasmic protein K09K1_13750 ENOG4105C1J atp-dependent rna helicase K09K1_13760 ENOG4105VYA Uncharacterized conserved protein (DUF2132) K09K1_13780 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) K09K1_13790 ENOG4105VEQ Cold shock protein K09K1_13810 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) K09K1_13830 ENOG4105CKI cobalamin synthesis protein K09K1_13840 ENOG4105C1J atp-dependent rna helicase K09K1_13880 ENOG4105CXC rtn protein K09K1_13890 ENOG4105DKW ABC transporter K09K1_13930 ENOG4105CVA phosphate K09K1_13960 ENOG4108ENQ Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) K09K1_13970 ENOG4105C1J atp-dependent rna helicase K09K1_13980 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) K09K1_13990 ENOG4105EQ2 LysR family Transcriptional regulator K09K1_14000 ENOG4105ENX hydrolase K09K1_14010 ENOG4105ENX hydrolase K09K1_14040 ENOG4105HF0 Membrane K09K1_14090 ENOG4105CKI cobalamin synthesis protein K09K1_14110 ENOG4105DR5 peptidase K09K1_14130 ENOG4105CKI cobalamin synthesis protein K09K1_14150 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K09K1_14160 ENOG41076UM multiple antibiotic resistance (MarC)-related protein K09K1_14180 ENOG4107SDU Methyl-accepting chemotaxis K09K1_14200 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase K09K1_14210 ENOG4105E39 Enoyl-CoA hydratase K09K1_14220 ENOG4107QX3 carboxylase K09K1_14230 ENOG4105C1G acyl-Coa dehydrogenase K09K1_14250 ENOG4105CHU acetyl-coa acetyltransferase K09K1_14260 ENOG4105C26 Dehydrogenase K09K1_14280 ENOG4105E39 Enoyl-CoA hydratase K09K1_14290 ENOG4105E39 Enoyl-CoA hydratase K09K1_14300 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase K09K1_14310 ENOG4105CHR reductase K09K1_14320 ENOG4105E2S oxidase) subunit II K09K1_14330 ENOG4105BZ9 Cytochrome C oxidase, subunit I K09K1_14340 ENOG4105CCU oxidase (Subunit III) K09K1_14360 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) K09K1_14370 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase K09K1_14400 ENOG4105C26 Dehydrogenase K09K1_14480 ENOG4105E5Z arginine transporter ATP-binding subunit K09K1_14490 ENOG4106PMH Extracellular solute-binding protein family 3 K09K1_14500 ENOG4105GBT ABC transporter K09K1_14510 ENOG4105DMR ABC, transporter K09K1_14530 ENOG4105DUM transcriptional regulator, lysR family K09K1_14560 ENOG4105EXG Transcriptional regulator K09K1_14570 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase K09K1_14580 ENOG4105C10 Electron transfer flavoprotein K09K1_14590 ENOG4107QSN dihydrolipoamide acetyltransferase K09K1_14610 ENOG4107RUY (E1 component), alpha subunit K09K1_14650 ENOG4105R8A Heat shock protein K09K1_14660 ENOG4106E5D Protein of unknown function (DUF461) K09K1_14710 ENOG4105ETX regulatoR K09K1_14780 ENOG4105BZU Histidine kinase K09K1_14800 ENOG4105C44 Serine transporter K09K1_14880 ENOG4105DG7 nitrate ABC transporter K09K1_14890 ENOG4105D7T ABC transporter K09K1_14900 ENOG4107QZF nitrite reductase NADPH large subunit K09K1_14960 ENOG4105F8J Adenylate Guanylate cyclase K09K1_15000 ENOG4105D9P serine threonine protein kinase K09K1_15040 ENOG4106VK6 Flagellar motor protein K09K1_15070 ENOG4108ZF3 Phosphatase K09K1_15160 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit K09K1_15210 ENOG4107RFY SbcCD D subunit K09K1_15220 ENOG4105EYH Exonuclease K09K1_15240 ENOG4105QNF Outer membrane lipoprotein K09K1_15260 ENOG4105CSX c4-dicarboxylate anaerobic carrier K09K1_15280 ENOG4105C5W Aldolase K09K1_15300 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) K09K1_15310 ENOG4105EV2 VWA domain protein interacting with AAA ATPase K09K1_15340 ENOG4105CC0 LysR family Transcriptional regulator K09K1_15350 ENOG4105CXG d-lactate dehydrogenase K09K1_15380 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) K09K1_15390 ENOG4108NVR Methyl-accepting chemotaxis K09K1_15540 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) K09K1_15550 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase K09K1_15570 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) K09K1_16000 ENOG4105DEN Luciferase family K09K1_16010 ENOG4105BZU Histidine kinase K09K1_16030 ENOG4105BZU Histidine kinase K09K1_16040 ENOG4105NXH GreA GreB family elongation factor K09K1_16060 ENOG4107QZF nitrite reductase NADPH large subunit K09K1_16070 ENOG4105WZK nitrite reductase NADPH small subunit K09K1_16080 ENOG4105TMB Formate nitrite transporter K09K1_16090 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) K09K1_16120 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter K09K1_16160 ENOG4105KNA -acetyltransferase K09K1_16170 ENOG4105VXR cytoplasmic protein K09K1_16180 ENOG4108ISG Major Facilitator K09K1_16190 ENOG4105K63 Thioredoxin K09K1_16200 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) K09K1_16240 ENOG4105EIP mannose-6-phosphate isomerase K09K1_16250 ENOG4105CXY transporter K09K1_16260 ENOG4105BZU Histidine kinase K09K1_16270 ENOG4108KX4 response regulator K09K1_16280 ENOG4105CXY transporter K09K1_16290 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) K09K1_16300 ENOG4105C5Q Transcriptional regulator K09K1_16310 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit K09K1_16340 ENOG4107TIF Phenazine biosynthesis protein, PhzF family K09K1_16410 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase K09K1_16420 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) K09K1_16430 ENOG4105UQX Mate efflux family protein K09K1_16440 ENOG4108K01 transcriptional regulator K09K1_16450 ENOG4105CGF Aromatic amino acid aminotransferase K09K1_16460 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) K09K1_16480 ENOG4105WXI Bacterial OB fold (BOF) protein K09K1_16490 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) K09K1_16500 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein K09K1_16510 ENOG4105E0C molybdate abc transporter K09K1_16520 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) K09K1_16550 ENOG4105BZU Histidine kinase K09K1_16580 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) K09K1_16590 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) K09K1_16650 ENOG4108M6U Universal stress protein A K09K1_16670 ENOG4105EJC lysr family transcriptional regulator K09K1_16990 ENOG4105MQ5 zona occludens toxin K09K1_17290 ENOG4105MQ5 zona occludens toxin K09K1_17430 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i K09K1_17460 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) K09K1_17480 ENOG4105C59 p-type ATPase K09K1_17510 ENOG4105DS0 Transcriptional regulator, Crp Fnr family K09K1_17520 ENOG4105Q9Y Universal stress protein K09K1_17530 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) K09K1_17570 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) K09K1_17580 ENOG4105F38 ABC transporter, permease K09K1_17590 ENOG4105D38 putrescine abc transporter K09K1_17600 ENOG4107RUE extracellular solute-binding protein family 1 K09K1_17610 ENOG4107RUE extracellular solute-binding protein family 1 K09K1_17620 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) K09K1_17690 ENOG4105QAX Iron-sulfur K09K1_17700 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) K09K1_17720 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) K09K1_17760 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) K09K1_17780 ENOG4105C5H ABC transporter K09K1_17790 ENOG4105BZU Histidine kinase K09K1_17800 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family K09K1_17830 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) K09K1_17840 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) K09K1_17850 ENOG4105CVM Molybdenum cofactor synthesis domain protein K09K1_17870 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) K09K1_17880 ENOG4106IUH DTW domain containing protein K09K1_17950 ENOG4107TT5 NLP P60 protein K09K1_17970 ENOG4105BZU Histidine kinase K09K1_17990 ENOG4105FGM Fructosamine kinase K09K1_18010 ENOG4108R6K riboflavin synthase, subunit alpha K09K1_18020 ENOG4107QI1 Mate efflux family protein K09K1_18060 ENOG41082AN stage II sporulation protein K09K1_18080 ENOG4107V1M polysaccharide export protein K09K1_18110 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family K09K1_18120 ENOG4107SBE Glycosyl transferase (Group 1 K09K1_18130 ENOG4107TYR Glycosyl Transferase K09K1_18190 ENOG4105CPK Glycosyl transferase (Group 1 K09K1_18200 ENOG4107R8N Glycosyl transferase, family 2 K09K1_18230 ENOG4105C94 Transporter K09K1_18260 ENOG4105CQ7 ATP-dependent helicase K09K1_18270 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) K09K1_18370 ENOG4105CFG Acts as a chaperone (By similarity) K09K1_18380 ENOG4105CFG Acts as a chaperone (By similarity) K09K1_18430 ENOG4105CR8 Transcriptional regulator K09K1_18450 ENOG4108VAU general secretion pathway protein G K09K1_18480 ENOG4105BZ1 (ABC) transporter K09K1_18500 ENOG4105E0K tonB-dependent siderophore receptor K09K1_18510 ENOG4105S6R Iron-hydroxamate transporter permease subunit K09K1_18520 ENOG4105J76 Periplasmic binding protein K09K1_18530 ENOG4105E0A ABC, transporter K09K1_18550 ENOG4105CPI Metal Dependent Phosphohydrolase K09K1_18560 ENOG4105E0U tyrosine-specific transport protein K09K1_18580 ENOG4105DHT Metal Dependent Phosphohydrolase K09K1_18600 ENOG4105EE5 Membrane protein terC K09K1_18620 ENOG41076CZ activating enzyme K09K1_18630 ENOG4105G0K glycine radical enzyme YjjI family K09K1_18640 ENOG410829K Lysine exporter protein (Lyse ygga) K09K1_18650 ENOG4105CPI Metal Dependent Phosphohydrolase K09K1_18660 ENOG4105BZU Histidine kinase K09K1_18670 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family K09K1_18690 ENOG4105C8P )-transporter K09K1_18730 ENOG4105BZU Histidine kinase K09K1_18740 ENOG41090KN UPF0303 protein K09K1_18750 ENOG4105D9R oxidoreductase K09K1_18760 ENOG4105E98 transcriptional regulator DeoR family K09K1_18790 ENOG4105DFG type I secretion outer membrane protein K09K1_18810 ENOG4108JJA ABC, transporter K09K1_18830 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) K09K1_18840 ENOG4105ENH Sulfatase K09K1_18870 ENOG4105C4X radical SAM domain protein K09K1_18900 ENOG4105ENH Sulfatase K09K1_18910 ENOG4105CZK Aspartate kinase K09K1_18920 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) K09K1_18930 ENOG4108JPW Aminotransferase K09K1_18940 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase K09K1_18950 ENOG4105C94 Transporter K09K1_19000 ENOG4108HQS Glycine betaine K09K1_19010 ENOG4105GIJ Glycine betaine K09K1_19020 ENOG4105E0M Sulfatase K09K1_19070 ENOG4105BZG amino acid carrier protein K09K1_19090 ENOG410829K Lysine exporter protein (Lyse ygga) K09K1_19100 ENOG4105CTD carboxy-peptidase K09K1_19350 ENOG4107TII Recombinase K09K1_19370 ENOG4105D1S lipid A biosynthesis K09K1_19400 ENOG4105CVG Homoserine O-transsuccinylase K09K1_19410 ENOG41090FY type IV pilus biogenesis stability protein PilW K09K1_19430 ENOG4105BZU Histidine kinase K09K1_19440 ENOG4105BZU Histidine kinase K09K1_19490 ENOG4105MSB protein, conserved in bacteria K09K1_19500 ENOG4108ZT1 Transcriptional regulator K09K1_19520 ENOG4105BZU Histidine kinase K09K1_19530 ENOG4108JPW Aminotransferase K09K1_19540 ENOG4105C26 Dehydrogenase K09K1_19550 ENOG4105DWY Agmatine deiminase K09K1_19570 ENOG4105CJP fad dependent oxidoreductase K09K1_19580 ENOG4105C26 Dehydrogenase K09K1_19590 ENOG4107VRI Transcriptional regulator K09K1_19600 ENOG4108Z86 Glutamine amidotransferase K09K1_19610 ENOG4105CFQ glutamine synthetase K09K1_19620 ENOG4107S6Z Na H antiporter K09K1_19650 ENOG4105KK4 UPF0060 membrane protein K09K1_19700 ENOG4105VTN Protein of unknown function (DUF1311) K09K1_19800 ENOG4108RXX maleylacetoacetate isomerase K09K1_19820 ENOG4105F1J Homogentisate 1,2-dioxygenase K09K1_19830 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase K09K1_19840 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) K09K1_19850 ENOG4107QSI ABC, transporter K09K1_19860 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component K09K1_19870 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component K09K1_19880 ENOG4105C3U ABC transporter K09K1_19890 ENOG4108JQ7 (ABC) transporter K09K1_19910 ENOG4107MM9 BNR Asp-box repeat-containing protein K09K1_19930 ENOG4105D38 putrescine abc transporter K09K1_19940 ENOG4105F38 ABC transporter, permease K09K1_19950 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) K09K1_19960 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) K09K1_19970 ENOG4105CIF Ornithine Cyclodeaminase K09K1_20000 ENOG4105CTU Proline racemase K09K1_20060 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) K09K1_20070 ENOG4108VKG metal-dependent hydrolase K09K1_20090 ENOG4105F04 LysR family Transcriptional regulator K09K1_20130 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) K09K1_20140 ENOG4108IU2 vtamin B12-transporter permease K09K1_20150 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) K09K1_20190 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) K09K1_20200 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) K09K1_20210 ENOG4105K4T epimerase K09K1_20220 ENOG4108ETY sodium dicarboxylate symporter K09K1_20510 ENOG4106CVF DNA replication protein K09K1_20570 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) K09K1_20690 ENOG4105CJB Exodeoxyribonuclease I K09K1_20700 ENOG4105VAW lrga family K09K1_20710 ENOG41067MG lrgb family K09K1_20720 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) K09K1_20730 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR K09K1_20740 ENOG4105FQ6 thiopurine methyltransferase K09K1_20760 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) K09K1_20780 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) K09K1_20790 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) K09K1_20870 ENOG4105K8R UPF0145 protein K09K1_20880 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) K09K1_20890 ENOG41082NX 50s ribosomal protein l35 K09K1_20900 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) K09K1_20910 ENOG4105C22 threonyL-tRNA synthetase K09K1_20940 ENOG4105CZE histidine utilization repressor K09K1_20950 ENOG4105CI2 imidazolone-5-propionate hydrolase K09K1_20960 ENOG41088SP formiminoglutamate hydrolase K09K1_20980 ENOG4105C84 Histidine ammonia-lyase K09K1_21010 ENOG4105CQB FAD linked oxidase domain protein K09K1_21040 ENOG4105CDV Ompa motb domain protein K09K1_21080 ENOG4105C8V SAICAR synthetase K09K1_21110 ENOG4105CQ7 ATP-dependent helicase K09K1_21120 ENOG4107R1I NAD-dependent malic enzyme K09K1_21130 ENOG4107GZ4 SanA protein K09K1_21140 ENOG4105C8P )-transporter K09K1_21150 ENOG4105BZU Histidine kinase K09K1_21190 ENOG4105C3M thioredoxin reductase K09K1_21200 ENOG4108JJ9 ABC, transporter K09K1_21210 ENOG4108JJ8 (ABC) transporter K09K1_21220 ENOG4105BZC d-serine deaminase K09K1_21230 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) K09K1_21250 ENOG4105BZU Histidine kinase K09K1_21310 ENOG4105DWU Membrane K09K1_21330 ENOG4105DY8 decarboxylase K09K1_21340 ENOG4106KNT transcriptional regulator K09K1_21370 ENOG41090BQ Glutaredoxin K09K1_21380 ENOG4105D0C transport protein K09K1_21390 ENOG4105RKW reductase (By K09K1_21400 ENOG4107QPN acyl-Coa dehydrogenase K09K1_21410 ENOG41067SE Tetr family transcriptional regulator K09K1_21420 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) K09K1_21460 ENOG4107QI1 Mate efflux family protein K09K1_21470 ENOG4105CGD Nad-dependent epimerase dehydratase K09K1_21490 ENOG4105C2C drug resistance transporter, Bcr CflA K09K1_21500 ENOG4105I08 Pseudouridine synthase K09K1_21510 ENOG4105CFI type iii restriction protein res subunit K09K1_21530 ENOG4105ETX regulatoR K09K1_21540 ENOG4105EB3 Histidine kinase K09K1_21550 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) K09K1_21570 ENOG4105CGH 5'-nucleotidase K09K1_21600 ENOG4105VNH ABC transporter solute-binding protein K09K1_21610 ENOG4105CXZ ABC transporter, permease K09K1_21620 ENOG4108VGW abc transporter atp-binding protein K09K1_21630 ENOG4108T9J Cdp-alcohol phosphatidyltransferase K09K1_21650 ENOG4108JUA Transcriptional regulator K09K1_21660 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) K09K1_21670 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) K09K1_21690 ENOG4108W1A pseudouridine synthase K09K1_21700 ENOG4105C8J )-transporter K09K1_21710 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) K09K1_21720 ENOG4105C28 cystathionine K09K1_21730 ENOG4107IFA Lipase (EC 3.1.1.3) K09K1_21750 ENOG4108R3E Dna-3-methyladenine glycosylase i K09K1_21790 ENOG4105FM1 phage shock protein C K09K1_21800 ENOG4105YYT phage shock protein B K09K1_21810 ENOG41087YS Phage shock protein A K09K1_21820 ENOG4105E51 psp operon transcriptional activator K09K1_21830 ENOG4108J59 Extracellular solute-binding protein, family 5 K09K1_21840 ENOG4108I5W peptide transport system, permease protein K09K1_21850 ENOG4108EU3 peptide transport system, permease K09K1_21860 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein K09K1_21870 ENOG4108JQ2 peptide transport system atp-binding protein K09K1_21890 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase K09K1_21920 ENOG4108J2R molybdopterin oxidoreductase K09K1_21970 ENOG4105TMB Formate nitrite transporter K09K1_22030 ENOG4107104 thymidine kinase K09K1_22040 ENOG4105C8N cysteinyl-tRNA synthetase K09K1_22050 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) K09K1_22060 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) K09K1_22070 ENOG4105D58 Diguanylate phosphodiesterase K09K1_22080 ENOG4105K5B UPF0225 protein K09K1_22120 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) K09K1_22140 ENOG4105CIH Imidazole acetol-phosphate transaminase K09K1_22150 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) K09K1_22160 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) K09K1_22170 ENOG4107S6Z Na H antiporter K09K1_22180 ENOG4108YX2 DNA-binding protein K09K1_22190 ENOG4107RE1 Inosine-guanosine kinase K09K1_22210 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) K09K1_22220 ENOG41075W9 High frequency lysogenization protein HflD homolog K09K1_22230 ENOG4107QTF adenylosuccinate lyase K09K1_22250 ENOG4105RHG K09K1_22270 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase K09K1_22300 ENOG4107FW0 short-chain dehydrogenase reductase K09K1_22320 ENOG4105D0M Protease HtpX homolog K09K1_22340 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) K09K1_22360 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) K09K1_22370 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) K09K1_22380 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) K09K1_22390 ENOG4105KSC Transcriptional regulator, TraR DksA family K09K1_22420 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) K09K1_22430 ENOG4105D1H recombination factor protein RarA K09K1_22440 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) K09K1_22450 ENOG4105CNU cell division protein FtsK K09K1_22460 ENOG4105EW9 transcriptional regulator AsnC family K09K1_22470 ENOG4105DCF alanine dehydrogenase K09K1_22490 ENOG4107R11 Transcriptional regulator K09K1_22510 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase K09K1_22520 ENOG4108NVR Methyl-accepting chemotaxis K09K1_22590 ENOG4105BZS acriflavin resistance protein K09K1_22600 ENOG4105C1P efflux transporter, rnd family, mfp subunit K09K1_22650 ENOG4105C4M (Ubiquinol oxidase) subunit I K09K1_22660 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii K09K1_22690 ENOG4108RNS Exports L-alanine (By similarity) K09K1_22700 ENOG4105BZU Histidine kinase K09K1_22720 ENOG4106032 Glutathionylspermidine synthase K09K1_22740 ENOG4105Z6B inner membrane protein yjfl K09K1_22760 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) K09K1_22770 ENOG4105UFD tol-pal system protein YbgF K09K1_22780 ENOG4105KCK Peptidoglycan-associated lipoprotein K09K1_22790 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) K09K1_22810 ENOG4105M8F Biopolymer transport protein exbD tolR K09K1_22820 ENOG4105E02 MotA TolQ exbB proton channel K09K1_22830 ENOG4107YD3 Thioesterase K09K1_22860 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii K09K1_22870 ENOG4105C4M (Ubiquinol oxidase) subunit I K09K1_22880 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) K09K1_22890 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) K09K1_22900 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) K09K1_22910 ENOG4105CDY transcriptional regulatory protein K09K1_22920 ENOG4105C9M aspartyl-trna synthetase K09K1_22930 ENOG41081XQ Conserved Protein K09K1_22940 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) K09K1_22950 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) K09K1_22960 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) K09K1_23000 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) K09K1_23010 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) K09K1_23020 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) K09K1_23030 ENOG4106371 Methyltransferase K09K1_23040 ENOG4107S90 membrAne K09K1_23050 ENOG4106WF9 DNA-binding transcriptional regulator TorR K09K1_23060 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) K09K1_23070 ENOG4105ETE Transcriptional regulator (LacI family K09K1_23080 ENOG4105HP8 regulator of competence-specific genes K09K1_23120 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) K09K1_23130 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) K09K1_23140 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) K09K1_23150 ENOG4105RKX Protein of unknown function (DUF2498) K09K1_23160 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase K09K1_23180 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) K09K1_23190 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate K09K1_23200 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) K09K1_23210 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit K09K1_23220 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) K09K1_23230 ENOG4105VEQ Cold shock protein K09K1_23250 ENOG4108R99 pseudouridine synthase K09K1_23270 ENOG4105SDR Outer membrane protein OmpT K09K1_23290 ENOG4105DVT helicase K09K1_23300 ENOG4105EJ9 Membrane K09K1_23310 ENOG4108URS primosomal replication protein n'' K09K1_23320 ENOG4106428 Protein of unknown function (DUF2496) K09K1_23330 ENOG4105CGK Exodeoxyribonuclease III K09K1_23360 ENOG4105DSP amino acid AbC transporter K09K1_23370 ENOG4105E89 ABC transporter K09K1_23380 ENOG4108JEH abc transporter atp-binding protein K09K1_23410 ENOG4105C6N Formate acetyltransferase K09K1_23430 ENOG4105F1A Pyruvate formate-lyase K09K1_23450 ENOG4105XWI UPF0304 protein K09K1_23460 ENOG4105CYN Serine protein kinase K09K1_23470 ENOG4106AKX UPF0229 protein K09K1_23480 ENOG4105ED1 spovr family K09K1_23490 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) K09K1_23500 ENOG4105W49 UPF0434 protein K09K1_23510 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) K09K1_23520 ENOG4105BZ1 (ABC) transporter K09K1_23530 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 K09K1_23550 ENOG4105D60 lipoprotein releasing system transmembrane protein K09K1_23560 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) K09K1_23570 ENOG4105D60 lipoprotein releasing system transmembrane protein K09K1_23590 ENOG4108JA2 transcriptioN-repair coupling factor K09K1_23620 ENOG4105CEP NADH dehydrogenase K09K1_23630 ENOG4105D0Y UPF0227 protein K09K1_23680 ENOG4105K59 histidine triad (HIT) protein K09K1_23690 ENOG4108NVR Methyl-accepting chemotaxis K09K1_23710 ENOG4107SXA Phosphorylase K09K1_23730 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) K09K1_23750 ENOG4105BZU Histidine kinase K09K1_23780 ENOG4108MNP Glycoprotein polysaccharide metabolism K09K1_23790 ENOG4105C29 acyl-CoA thioesterase K09K1_23810 ENOG4108XM1 transcriptional regulator AsnC family K09K1_23820 ENOG4105C6T cysteine synthase K09K1_23850 ENOG4105BZS acriflavin resistance protein K09K1_23860 ENOG4105EP1 Efflux transporter rnd family, mfp subunit K09K1_23950 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) K09K1_23960 ENOG4105HMI Membrane K09K1_23980 ENOG4105CEY Amp-dependent synthetase and ligase K09K1_23990 ENOG4105DNI Converts SHCHC to OSB (By similarity) K09K1_24000 ENOG4108IPT Naphthoate synthase K09K1_24020 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) K09K1_24030 ENOG4105E4F Isochorismate synthase K09K1_24040 ENOG4105CHM Aminotransferase K09K1_24050 ENOG4105DK2 UPF0207 protein K09K1_24060 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein K09K1_24090 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein K09K1_24100 ENOG4105EIN peptidylprolyl cis-trans isomerase K09K1_24110 ENOG4105K70 DNA-binding protein K09K1_24120 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) K09K1_24130 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) K09K1_24140 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) K09K1_24150 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation K09K1_24160 ENOG4105CQZ Histidine kinase K09K1_24170 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family K09K1_24190 ENOG4105CG6 trap dicarboxylate transporter dctm subunit K09K1_24200 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ K09K1_24210 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit K09K1_24220 ENOG4105CNG UPF0061 protein K09K1_24270 ENOG4107ZYR domain protein K09K1_24280 ENOG4105C1J atp-dependent rna helicase K09K1_24350 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) K09K1_24390 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) K09K1_24400 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) K09K1_24410 ENOG4105C84 Histidine ammonia-lyase K09K1_24460 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) K09K1_24470 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) K09K1_24480 ENOG4105C2D reductase K09K1_24490 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) K09K1_24500 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) K09K1_24520 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) K09K1_24530 ENOG4105D9N nucleoside K09K1_24550 ENOG4105CVE Lytic murein transglycosylase K09K1_24560 ENOG4105VNG YcgL domain-containing protein K09K1_24570 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) K09K1_24580 ENOG4107QMS site-determining protein K09K1_24590 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) K09K1_24600 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) K09K1_24610 ENOG4105CEY Amp-dependent synthetase and ligase K09K1_24620 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) K09K1_24630 ENOG4105R8X Outer membrane lipoprotein Slp K09K1_24650 ENOG41072GX Peptidase M22 Glycoprotease K09K1_24660 ENOG4105DVT helicase K09K1_24670 ENOG4105CIY formyltetrahydrofolate deformylase K09K1_24680 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap K09K1_24700 ENOG4106ZCM YecM protein K09K1_24710 ENOG4105C75 arginyL-tRNA synthetase K09K1_24760 ENOG4105XFK Ferrous iron transport protein A K09K1_24770 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) K09K1_24780 ENOG4105NXV High-affinity zinc uptake system protein K09K1_24790 ENOG4105FDK ABC transporter K09K1_24800 ENOG4105FAV ABC, transporter K09K1_24810 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha K09K1_24820 ENOG4105CMV Succinyl-CoA synthetase subunit beta K09K1_24830 ENOG4105C7S Dehydrogenase K09K1_24840 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 K09K1_24850 ENOG4105E33 succinate dehydrogenase K09K1_24860 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) K09K1_24870 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein K09K1_24880 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit K09K1_24890 ENOG4105BZN citrate synthase K09K1_24900 ENOG4107QNR UPF0135 protein K09K1_24920 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 K09K1_24930 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) K09K1_24940 ENOG4105EV9 Alpha Beta Hydrolase K09K1_24960 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) K09K1_24980 ENOG41090R7 Ferric uptake K09K1_24990 ENOG4105CX6 glutaminyL-tRNA synthetase K09K1_25000 ENOG4105CI1 PTS System K09K1_25010 ENOG4105CE4 GlcNAc 6-P deacetylase K09K1_25020 ENOG4105E2R ROK family K09K1_25030 ENOG4105CKD glutathione-regulated potassium-efflux system protein K09K1_25040 ENOG4105CAQ asparagine synthetase K09K1_25050 ENOG4105MDZ Transcriptional activator rfaH K09K1_25060 ENOG4105DUX Transporter K09K1_25070 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) K09K1_25080 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) K09K1_25090 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) K09K1_25100 ENOG4108DQ1 activator toxR K09K1_25140 ENOG4108RE9 Phosphodiesterase K09K1_25200 ENOG4105ECP epimerase K09K1_25210 ENOG4105E1F short-chain dehydrogenase reductase K09K1_25220 ENOG4107QR8 Thioredoxin K09K1_25230 ENOG4105EJG cellulose synthase K09K1_25240 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) K09K1_25250 ENOG4107EEX Cellulose synthase regulator protein K09K1_25260 ENOG4107QZ7 Cellulose synthase catalytic subunit K09K1_25270 ENOG4105UTS cellulose synthase operon protein YhjQ K09K1_25290 ENOG4105U74 cellulose biosynthesis protein BcsE K09K1_25310 ENOG4105D1V cellulose synthase operon protein YhjU K09K1_25320 ENOG4107QX8 SPFH domain, Band 7 family protein K09K1_25370 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) K09K1_25380 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) K09K1_25390 ENOG4105EXN Sulfate transport protein CysZ K09K1_25400 ENOG4105C6T cysteine synthase K09K1_25410 ENOG4105KZ7 phosphocarrier protein hpr K09K1_25430 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) K09K1_25440 ENOG4105C5Y PTS System K09K1_25460 ENOG4105I03 Flagellin K09K1_25470 ENOG4105I03 Flagellin K09K1_25480 ENOG4105DTJ flagellar hook-associated protein K09K1_25500 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj K09K1_25510 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) K09K1_25520 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) K09K1_25530 ENOG4105CGA flagellar basal-body rod protein FlgG K09K1_25540 ENOG4108KPB Flagellar basal-body rod protein FlgF K09K1_25550 ENOG4105BZE flagellar hook protein, FlgE K09K1_25560 ENOG4105W00 Flagellar hook capping protein K09K1_25570 ENOG4108ZC9 flagellar basal-body rod protein flgc K09K1_25580 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) K09K1_25590 ENOG4105BZU Histidine kinase K09K1_25600 ENOG4107R88 Chemotaxis protein (CheV) K09K1_25690 ENOG4105UYK outer membrane protein a K09K1_25700 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) K09K1_25720 ENOG41081QG Porin Gram-negative type K09K1_25730 ENOG4105C59 p-type ATPase K09K1_25760 ENOG4105E2D ec 3.2.1.52 K09K1_25810 ENOG4108DG9 Smr protein MutS2 K09K1_25820 ENOG4105FE9 pseudouridine synthase K09K1_25830 ENOG4108Z66 YbaK ebsC protein K09K1_25840 ENOG4105CGH 5'-nucleotidase K09K1_25850 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase K09K1_25860 ENOG41063JG Transcriptional regulator K09K1_25870 ENOG4108YY7 Invasion gene expression up-regulator SirB K09K1_25880 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) K09K1_25890 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) K09K1_25900 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) K09K1_25910 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) K09K1_25920 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) K09K1_25930 ENOG4105C5T Phosphoribosyl pyrophosphate synthase K09K1_25940 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) K09K1_25950 ENOG4105C3G gtp-binding protein K09K1_26160 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family K09K1_26170 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) K09K1_26180 ENOG4105C9A Phoh family K09K1_26190 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) K09K1_26200 ENOG4108JU5 Magnesium and cobalt efflux protein K09K1_26210 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) K09K1_26220 ENOG4107PAI alpha helical protein K09K1_26230 ENOG4105C8T Leucyl-tRNA synthetase K09K1_26240 ENOG4108U2H Rare lipoprotein B K09K1_26250 ENOG4105DJF DNA polymerase III, delta' subunit K09K1_26260 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) K09K1_26270 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) K09K1_26280 ENOG4105CJN penicillin-binding protein K09K1_26290 ENOG4105CNI cell division protein FtsW K09K1_26300 ENOG4105K6T rare lipoprotein A K09K1_26310 ENOG4105DZ1 carboxypeptidase K09K1_26320 ENOG4108Z43 UPF0250 protein K09K1_26330 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) K09K1_26340 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) K09K1_26350 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) K09K1_26360 ENOG4108JYZ YitT family K09K1_26390 ENOG4105CG3 alpha amylase, catalytic region K09K1_26400 ENOG4105C5Y PTS System K09K1_26410 ENOG4105D4X repressor K09K1_26420 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase K09K1_26430 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) K09K1_26440 ENOG4108UMI ABC transporter, permease K09K1_26450 ENOG4105D01 (LipO)protein K09K1_26460 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein K09K1_26470 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) K09K1_26480 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) K09K1_26500 ENOG4105BZU Histidine kinase K09K1_26510 ENOG4105EWT decarboxylase family K09K1_26520 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease K09K1_26530 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) K09K1_26540 ENOG4105M08 Membrane K09K1_26560 ENOG4105ETT transcriptional Regulator, LysR family K09K1_26570 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) K09K1_26580 ENOG4106VK6 Flagellar motor protein K09K1_26590 ENOG4105E14 MotA TolQ exbB proton channel K09K1_26600 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) K09K1_26610 ENOG4105CTB Polyprenyl synthetase K09K1_26620 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) K09K1_26630 ENOG4108ZAI phosphatidylglycerophosphatase a K09K1_26640 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) K09K1_26650 ENOG4107YIM Involved in the transcription termination process (By similarity) K09K1_26660 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) K09K1_26690 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) K09K1_26700 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) K09K1_26710 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) K09K1_26720 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) K09K1_26730 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) K09K1_26740 ENOG4108DJV Fermentation respiration switch protein K09K1_26750 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) K09K1_26760 ENOG4105C7N Xanthine uracil vitamin C permease K09K1_26770 ENOG4105CIN aminoacyl-histidine dipeptidase K09K1_26830 ENOG4108ETH Formylglycinamide ribotide synthetase K09K1_26840 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) K09K1_26850 ENOG4108Z6B deaminase K09K1_26860 ENOG4105CFC Transporter K09K1_26920 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) K09K1_26930 ENOG4105CFG Acts as a chaperone (By similarity) K09K1_26940 ENOG4105CK2 sodium dicarboxylate symporter K09K1_26960 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K09K1_26970 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) K09K1_26990 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) K09K1_27010 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) K09K1_27020 ENOG4105VDB UPF0125 protein K09K1_27030 ENOG4108Z1B Cyclase dehydrase K09K1_27040 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) K09K1_27080 ENOG4105ETT transcriptional Regulator, LysR family K09K1_27090 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase K09K1_27130 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) K09K1_27140 ENOG4108IQK o-acetylhomoserine K09K1_27160 ENOG4105MWK D-amino acid dehydrogenase, small subunit K09K1_27170 ENOG4105BZG amino acid carrier protein K09K1_27180 ENOG4106HK8 GPR1 FUN34 yaaH family protein K09K1_27200 ENOG4107S6Z Na H antiporter K09K1_27340 ENOG4105DFP Integrase K09K1_27350 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) K09K1_27360 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) K09K1_27370 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) K09K1_27400 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) K09K1_27410 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) K09K1_27420 ENOG4105N21 Membrane K09K1_27430 ENOG4105CUT histidyl-tRNA synthetase K09K1_27440 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) K09K1_27460 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K09K1_27470 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) K09K1_27480 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) K09K1_27490 ENOG4105WVQ Fe-S assembly protein IscX K09K1_27500 ENOG4108ZIT Ferredoxin, 2FE-2S K09K1_27510 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB K09K1_27520 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) K09K1_27530 ENOG4108Z4V iron-sulfur cluster assembly K09K1_27540 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins K09K1_27550 ENOG4105C3J Cysteine desulfurase K09K1_27560 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family K09K1_27570 ENOG4105CVS RNA methyltransferase TrmH family, group 1 K09K1_27580 ENOG4105ECY inositol monophosphatase K09K1_27610 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) K09K1_27620 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) K09K1_27630 ENOG4105VIE preprotein translocase, subunit YajC K09K1_27640 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) K09K1_27650 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) K09K1_27670 ENOG4105W87 Cbs domain K09K1_27680 ENOG4108I9X Isocitrate lyase K09K1_27690 ENOG4107QP3 malate synthase g K09K1_27700 ENOG4105C5Q Transcriptional regulator K09K1_27710 ENOG4105D3R alkyl hydroperoxide reductase K09K1_27720 ENOG4106N3A copper homeostasis protein cutc K09K1_27730 ENOG4105CSR polyphosphate kinase 2 K09K1_27750 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) K09K1_27760 ENOG4105E2Z phosphate ABC transporter (Permease K09K1_27770 ENOG4105C8U phosphate abc transporter K09K1_27780 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) K09K1_27790 ENOG4105C9X ppx gppa phosphatase K09K1_27810 ENOG4105BZU Histidine kinase K09K1_27820 ENOG4105CK6 Two component transcriptional regulator (Winged helix family K09K1_27830 ENOG4105DH7 May be involved in recombination (By similarity) K09K1_27840 ENOG4105CFP Peptidase U32 K09K1_27850 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding K09K1_27970 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit K09K1_27980 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase K09K1_27990 ENOG4105C34 Pseudouridine synthase K09K1_28000 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K09K1_28020 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA K09K1_28040 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) K09K1_28050 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) K09K1_28060 ENOG4107SC1 transglycosylase K09K1_28070 ENOG4105C5H ABC transporter K09K1_28090 ENOG4105DR5 peptidase K09K1_28100 ENOG4105EHE chorismate mutase- prephenate dehydrogenase K09K1_28110 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) K09K1_28120 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) K09K1_28130 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) K09K1_28140 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K09K1_28180 ENOG4108HRK Histidine kinase K09K1_28190 ENOG4108NEV two component transcriptional regulator, LytTR family K09K1_28210 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) K09K1_28220 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase K09K1_28230 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) K09K1_28240 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) K09K1_28250 ENOG4105DTN riboflavin biosynthesis protein ribF K09K1_28260 ENOG4105CJR Integral membrane protein (MviN K09K1_28270 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) K09K1_28280 ENOG41080HT Transcriptional regulator, arsr family K09K1_28290 ENOG41063Z6 transcriptional regulator, lysR family K09K1_28320 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) K09K1_28330 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) K09K1_28340 ENOG4105HF0 Membrane K09K1_28350 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase K09K1_28360 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) K09K1_28370 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) K09K1_28390 ENOG4105CPC Aldo Keto reductase K09K1_28420 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family K09K1_28430 ENOG4105CRK lysyL-tRNA synthetase K09K1_28440 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) K09K1_28450 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) K09K1_28460 ENOG4105T95 Thiol disulfide interChange protein K09K1_28470 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) K09K1_28480 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) K09K1_28490 ENOG4105CWM branched-chain amino acid transport system II carrier protein K09K1_28500 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) K09K1_28510 ENOG4105C1J atp-dependent rna helicase K09K1_28520 ENOG4105D1Q UPF0246 protein K09K1_28530 ENOG4105BZG amino acid carrier protein K09K1_28560 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) K09K1_28570 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) K09K1_28580 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) K09K1_28600 ENOG4105D98 threonine synthase K09K1_28610 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) K09K1_28640 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) K09K1_28660 ENOG41065U4 response regulator K09K1_28680 ENOG4105BZU Histidine kinase K09K1_28700 ENOG4105N5T Radical SAM Protein K09K1_28730 ENOG4105CBC glutamate synthase K09K1_28740 ENOG4105BZ8 glutamate synthase K09K1_28760 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) K09K1_28770 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) K09K1_28780 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) K09K1_28790 ENOG4105EN6 Membrane K09K1_28800 ENOG4105VP0 transcriptional regulator, lysR family K09K1_28810 ENOG4105EJ9 Membrane K09K1_28840 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain K09K1_28850 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain K09K1_28860 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) K09K1_28870 ENOG4105M6F mutator MutT protein K09K1_28880 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving K09K1_28900 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) K09K1_28910 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) K09K1_28920 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) K09K1_28930 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) K09K1_28940 ENOG4105DFU Cell wall formation (By similarity) K09K1_28950 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) K09K1_28970 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) K09K1_28980 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) K09K1_28990 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) K09K1_29000 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) K09K1_29010 ENOG4105CJN penicillin-binding protein K09K1_29020 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) K09K1_29030 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) K09K1_29040 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) K09K1_29060 ENOG41082RQ UPF0102 protein K09K1_29070 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) K09K1_29080 ENOG4105W4M Transport-associated protein K09K1_29110 ENOG4105KB2 stringent starvation protein b K09K1_29120 ENOG4107MKT Stringent starvation protein a K09K1_29130 ENOG4105EIX cytochrome c1 K09K1_29140 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) K09K1_29150 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) K09K1_29160 ENOG4108UJD 30S ribosomal protein S9 K09K1_29170 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) K09K1_29180 ENOG4105D6Z AFG1 family ATPase K09K1_29190 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III K09K1_29200 ENOG4105C0H protease K09K1_29210 ENOG4105C0H protease K09K1_29220 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) K09K1_29230 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) K09K1_29240 ENOG4105IPS esterase K09K1_29250 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) K09K1_29260 ENOG4108SX3 cytoplasmic protein K09K1_29270 ENOG41087AY ADP-Ribose pyrophosphatase K09K1_29280 ENOG4105DFG type I secretion outer membrane protein K09K1_29290 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) K09K1_29300 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) K09K1_29310 ENOG4105C8Q Methyl-accepting chemotaxis K09K1_29330 ENOG4105I7R Adenylate cyclase K09K1_29340 ENOG4107IX6 phosphate transport regulator K09K1_29350 ENOG4105CJ3 phosphate transporter K09K1_29360 ENOG4106MWK domain protein K09K1_29370 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) K09K1_29400 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K09K1_29410 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) K09K1_29420 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K09K1_29430 ENOG4107ZVW dihydroneopterin aldolase K09K1_29440 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) K09K1_29450 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) K09K1_29460 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) K09K1_29470 ENOG4105VCC 30S ribosomal protein S21 K09K1_29480 ENOG4105KTH gatB Yqey K09K1_29490 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) K09K1_29500 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) K09K1_29520 ENOG4105D01 (LipO)protein K09K1_29560 ENOG4105CTS PTS system mannitol-specific K09K1_29570 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase K09K1_29580 ENOG4105E61 Mannitol repressor protein K09K1_29610 ENOG4108UTZ Dihydroxyacetone kinase K09K1_29620 ENOG4105CMT Dihydroxyacetone kinase K09K1_29640 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) K09K1_29650 ENOG410804X Transcriptional regulator K09K1_29660 ENOG4105CA9 Pyruvate kinase K09K1_29680 ENOG4105BZU Histidine kinase K09K1_29690 ENOG4108ZP8 Acetolactate synthase small subunit K09K1_29700 ENOG4105C7K acetolactate synthase K09K1_29710 ENOG4108IQE Amp-dependent synthetase and ligase K09K1_29720 ENOG41064T2 transcriptional regulator, lysR family K09K1_29760 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) K09K1_29770 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) K09K1_29780 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) K09K1_29790 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) K09K1_29810 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) K09K1_29820 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) K09K1_29830 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) K09K1_29840 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) K09K1_29850 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) K09K1_29860 ENOG4105NWN ApaG protein K09K1_29870 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) K09K1_29880 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) K09K1_29890 ENOG4107XM3 UPF0442 protein K09K1_29900 ENOG4105DWK Membrane K09K1_29910 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K09K1_29920 ENOG4105K46 50S ribosomal protein l27 K09K1_29930 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) K09K1_29940 ENOG4105EAH synthase K09K1_29960 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) K09K1_29970 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) K09K1_30010 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase K09K1_30020 ENOG4105CC0 LysR family Transcriptional regulator K09K1_30030 ENOG4107T0D ABC, transporter K09K1_30040 ENOG4106SMU thiamine transporter membrane protein K09K1_30050 ENOG4105DP9 ABC transporter K09K1_30060 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K09K1_30070 ENOG4105DFU Cell wall formation (By similarity) K09K1_30080 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 K09K1_30090 ENOG4105F0N pyrophosphate phospho-hydrolase K09K1_30110 ENOG41066HZ AIG2-like family K09K1_30120 ENOG4105MA0 exported protein K09K1_30130 ENOG4105CFU surface antigen K09K1_30140 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) K09K1_30150 ENOG41061GZ Protein of unknown function (DUF1107) K09K1_30160 ENOG4108UUE Transcriptional regulator K09K1_30190 ENOG4108I0Y (ABC) transporter K09K1_30240 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) K09K1_30260 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) K09K1_30270 ENOG4105C11 sulfate adenylyltransferase), subunit 2 K09K1_30280 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) K09K1_30290 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic K09K1_30310 ENOG4105C1J atp-dependent rna helicase K09K1_30320 ENOG4107YB6 acetyltransferase, (GNAT) family K09K1_30340 ENOG4108V1T peptidylprolyl cis-trans isomerase K09K1_30360 ENOG4108ZT0 50S ribosomal protein l17 K09K1_30370 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) K09K1_30380 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) K09K1_30390 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) K09K1_30400 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K09K1_30420 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) K09K1_30430 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) K09K1_30440 ENOG4105VPB 50S ribosomal protein L30 K09K1_30450 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) K09K1_30470 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) K09K1_30480 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) K09K1_30490 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) K09K1_30500 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K09K1_30510 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) K09K1_30520 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) K09K1_30530 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal K09K1_30540 ENOG41083MP 50s ribosomal protein l29 K09K1_30550 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) K09K1_30560 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) K09K1_30570 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) K09K1_30580 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) K09K1_30590 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K09K1_30600 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) K09K1_30610 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) K09K1_30620 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) K09K1_30630 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) K09K1_30640 ENOG4105VFB Binds the 23S rRNA (By similarity) K09K1_30650 ENOG4105C25 Primosomal protein n' K09K1_30660 ENOG4105ETE Transcriptional regulator (LacI family K09K1_30690 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) K09K1_30700 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) K09K1_30730 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase K09K1_30740 ENOG4105YGP holo-ACP synthase CitX K09K1_30750 ENOG4105CHY citrate lyase, alpha K09K1_30760 ENOG4105CI0 Citrate lyase K09K1_30770 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) K09K1_30780 ENOG4105DUA (citrate (pro-3S)-lyase ligase K09K1_30810 ENOG4107QSA Oxaloacetate decarboxylase K09K1_30820 ENOG4105D9Q decarboxylase (Beta subunit) K09K1_30830 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism K09K1_30840 ENOG4106YYS transcriptional regulatory protein K09K1_30870 ENOG4108YGG dna repair protein K09K1_30930 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase K09K1_30940 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) K09K1_30950 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) K09K1_30960 ENOG4105CBT Fructose-1,6-bisphosphatase K09K1_31010 ENOG4105CP7 Triose-phosphate isomerase K09K1_31020 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase K09K1_31070 ENOG4105JEU Glycosyl transferase, family 2 K09K1_31130 ENOG4105ESV Glycosyl transferase, family 4 K09K1_31140 ENOG4105CY0 Metallo-Beta-Lactamase K09K1_31170 ENOG4107RA4 Glycosyl transferase (Group 1 K09K1_31190 ENOG4105CG5 Glycosyl transferase (Group 1 K09K1_31250 ENOG4105DAY polysaccharide export protein K09K1_31300 ENOG4105E3R (LipO)protein K09K1_31310 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) K09K1_31370 ENOG4105XA0 heptosyltransferase ii K09K1_31380 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase K09K1_31390 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) K09K1_31470 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) K09K1_31480 ENOG4105C1B dTDP-glucose 4-6-dehydratase K09K1_31490 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) K09K1_31500 ENOG41080IJ Diacylglycerol kinase K09K1_31510 ENOG4105DKP glycosyl transferase, family 9 K09K1_31520 ENOG4106WTF Glycosyl transferase, family 2 K09K1_31540 ENOG4108JMC lipopolysaccharide core biosynthesis protein K09K1_31550 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) K09K1_31560 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) K09K1_31590 ENOG4105KDC 50s ribosomal protein l28 K09K1_31600 ENOG4105W5Q DNA repair protein (RadC K09K1_31610 ENOG4105C8Q Methyl-accepting chemotaxis K09K1_31620 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase K09K1_31630 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) K09K1_31640 ENOG4105D1S lipid A biosynthesis K09K1_31650 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) K09K1_31660 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) K09K1_31670 ENOG4105DSJ YicC domain protein K09K1_31690 ENOG4108JQ7 (ABC) transporter K09K1_31710 ENOG4107QRA Extracellular solute-binding protein, family 5 K09K1_31720 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component K09K1_31730 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component K09K1_31780 ENOG4109015 Biopolymer transport protein exbD tolR K09K1_31810 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) K09K1_31820 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) K09K1_31830 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) K09K1_31840 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase K09K1_31850 ENOG4105CB5 ATP-dependent DNA helicase recG K09K1_31860 ENOG4105C2W permease K09K1_31870 ENOG4105E0F Histidine kinase K09K1_31880 ENOG4105DPZ Two component transcriptional regulator (Winged helix family K09K1_31900 ENOG4108RRZ Transcription elongation factor GreB K09K1_31920 ENOG4105BZM domain protein K09K1_31940 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) K09K1_31950 ENOG4105MJ2 Competence protein K09K1_31960 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) K09K1_31970 ENOG4107RK2 ADP-ribose diphosphatase NudE K09K1_31990 ENOG4105PIC general secretion pathway protein N K09K1_32000 ENOG4105U1E general secretion pathway protein M K09K1_32010 ENOG4108BY5 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) K09K1_32020 ENOG4108RTD type II secretion system protein K K09K1_32030 ENOG4108WWZ General secretion pathway protein J K09K1_32040 ENOG4105X5Z General secretion pathway protein I K09K1_32050 ENOG4105VWV general secretion pathway protein h K09K1_32060 ENOG4108VAU general secretion pathway protein G K09K1_32070 ENOG4105D7Q type ii secretion system K09K1_32080 ENOG4107QHF type ii secretion system protein e K09K1_32100 ENOG4108XKW General secretion pathway protein C K09K1_32110 ENOG4105VEJ Heat shock protein K09K1_32120 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) K09K1_32130 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase K09K1_32150 ENOG4105SUU thioesterase domain K09K1_32160 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) K09K1_32170 ENOG4107S2Z UPF0761 membrane protein K09K1_32190 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) K09K1_32210 ENOG4105C5F glutamine synthetase K09K1_32230 ENOG4105CUX Signal transduction histidine kinase K09K1_32240 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family K09K1_32250 ENOG4105BZU Histidine kinase K09K1_32260 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) K09K1_32270 ENOG4105D4P Coproporphyrinogen iii oxidase K09K1_32280 ENOG4105XCT Protein of unknown function (DUF2489) K09K1_32290 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) K09K1_32310 ENOG4106RE7 Cytochrome K09K1_32320 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) K09K1_32330 ENOG4105C2M dna polymerase I K09K1_32350 ENOG4105KD7 acetyltransferase K09K1_32360 ENOG4105D52 delta-aminolevulinic acid dehydratase K09K1_32370 ENOG4105F8V Hydrolase, tatD family K09K1_32380 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) K09K1_32390 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) K09K1_32400 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) K09K1_32410 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) K09K1_32420 ENOG4105JC1 sterol-binding domain protein K09K1_32430 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) K09K1_32440 ENOG4105CGY Dna recombination protein K09K1_32460 ENOG4105BZU Histidine kinase K09K1_32470 ENOG4105DSF transport protein K09K1_32530 ENOG4107TE5 Lipid kinase K09K1_32580 ENOG4108JUA Transcriptional regulator K09K1_32590 ENOG4105CBX hi0933 family K09K1_32600 ENOG4108V6B universal stress protein B K09K1_32610 ENOG41090A1 ferritin K09K1_32620 ENOG4108M6U Universal stress protein A K09K1_32630 ENOG4105EMK carboxylate amino acid amine transporter K09K1_32650 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) K09K1_32660 ENOG4105BZU Histidine kinase K09K1_32670 ENOG4108VVK transcriptional Regulator, AsnC K09K1_32680 ENOG4105DGW oligopeptidase A K09K1_32690 ENOG4105D6S protein involved in catabolism of external DNA K09K1_32700 ENOG4105DC8 reductase K09K1_32710 ENOG4107RSM transcriptional regulator K09K1_32720 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) K09K1_32730 ENOG4108UHU Aldolase K09K1_32740 ENOG4105C6Z Gluconate K09K1_32750 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family K09K1_32760 ENOG4105C01 Dihydroxy-acid dehydratase K09K1_32770 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) K09K1_32780 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) K09K1_32790 ENOG41064T2 transcriptional regulator, lysR family K09K1_32800 ENOG4105DIQ Transcriptional regulator K09K1_32820 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component K09K1_32830 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component K09K1_32840 ENOG4107QSI ABC, transporter K09K1_32850 ENOG4108JQ6 ABC transporter K09K1_32920 ENOG4105MPD Cytochrome K09K1_32930 ENOG4105C4R Atp-dependent dna helicase K09K1_32940 ENOG41067SE Tetr family transcriptional regulator K09K1_32950 ENOG410624X efflux transporter, rnd family, mfp subunit K09K1_32960 ENOG4105BZS acriflavin resistance protein K09K1_32970 ENOG4105W0Z cytoplasmic protein K09K1_32980 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase K09K1_32990 ENOG4105EMY transcriptional regulator K09K1_33060 ENOG4108RR8 protoporphyrinogen oxidase K09K1_33070 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) K09K1_33080 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein K09K1_33090 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase K09K1_33100 ENOG4105CHU acetyl-coa acetyltransferase K09K1_33110 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family K09K1_33140 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) K09K1_33170 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit K09K1_33180 ENOG4105C38 Glycyl-tRNA synthetase beta subunit K09K1_33190 ENOG4107T9C Alpha amylase catalytic region K09K1_33200 ENOG4105JKW Valine--pyruvate aminotransferase K09K1_33210 ENOG4108ZNX Heat shock protein K09K1_33240 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) K09K1_33250 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) K09K1_33260 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) K09K1_33270 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) K09K1_33280 ENOG4105EAB amino acid AbC transporter K09K1_33290 ENOG4105E5Q amino acid AbC transporter K09K1_33300 ENOG4105CDA abc transporter atp-binding protein K09K1_33320 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) K09K1_33330 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins K09K1_33340 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) K09K1_33350 ENOG4105QTB Flavodoxin K09K1_33360 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) K09K1_33370 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) K09K1_33380 ENOG4107QJE Chromosome Partitioning Protein K09K1_33390 ENOG4105FA0 parb-like partition protein K09K1_33400 ENOG410684E atp synthase K09K1_33410 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) K09K1_33420 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) K09K1_33440 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) K09K1_33450 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) K09K1_33460 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) K09K1_33470 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) K09K1_33480 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) K09K1_33500 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) K09K1_33510 ENOG4105EAD ABC transporter K09K1_33520 ENOG4105F87 Dehydratase K09K1_33530 ENOG4105CZQ inner membrane transport protein YdhC K09K1_33540 ENOG4105F52 Transcriptional regulator K09K1_33550 ENOG4105C7B Threonine dehydratase K09K1_33560 ENOG4105C01 Dihydroxy-acid dehydratase K09K1_33570 ENOG4105CM2 brancheD-chain amino acid aminotransferase K09K1_33580 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit K09K1_33630 ENOG4106HNH Acyl-transferase K09K1_33640 ENOG4108Z33 Thiol disulfide Interchange Protein K09K1_33650 ENOG4105E27 serine threonine protein kinase K09K1_33670 ENOG4105PC1 Conserved Protein K09K1_33690 ENOG4108N23 SpoOM-related protein K09K1_33700 ENOG4108UT2 hemolysin iii K09K1_33720 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) K09K1_33730 ENOG4105C1A potassium transporter peripheral membrane K09K1_33740 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B K09K1_33750 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) K09K1_33760 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) K09K1_33780 ENOG4105C79 DNA protecting protein DprA K09K1_33790 ENOG4108RPN Protein smg homolog K09K1_33800 ENOG4108WI1 Dna topoisomerase K09K1_33810 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit K09K1_33820 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) K09K1_33830 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) K09K1_33840 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) K09K1_33850 ENOG4105E2X shikimate dehydrogenase K09K1_33860 ENOG4105SG3 Protein of unknown function (DUF1488) K09K1_33870 ENOG4108Z0R Transferase K09K1_33970 ENOG4105E3B Multicopper oxidase K09K1_33980 ENOG4105WMR Protein CrcB homolog K09K1_33990 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) K09K1_34010 ENOG4105D06 uba thif-type nad fad binding protein K09K1_34020 ENOG4105WHD thiamine biosynthesis protein ThiS K09K1_34030 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) K09K1_34040 ENOG4105D41 biosynthesis protein thiH K09K1_34050 ENOG4105DC7 peptidase M24 K09K1_34050 ENOG4105DC7 peptidase M24 K09K1_34110 ENOG4105E18 UPF0276 protein K09K1_34130 ENOG4105C4R Atp-dependent dna helicase K09K1_34140 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) K09K1_34170 ENOG4105FR1 rard protein K09K1_34180 ENOG4105C9U ATP-dependent DNA helicase RecQ K09K1_34200 ENOG4105EX9 Membrane K09K1_34220 ENOG4105C9X ppx gppa phosphatase K09K1_34230 ENOG4105C1J atp-dependent rna helicase K09K1_34240 ENOG4105K63 Thioredoxin K09K1_34250 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) K09K1_34270 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) K09K1_34280 ENOG4108ZIT Ferredoxin, 2FE-2S K09K1_34290 ENOG4107QK7 reductase K09K1_34390 ENOG4105ECF c-methyltransferase K09K1_34400 ENOG41076E6 Uroporphyrinogen-III Synthase K09K1_34410 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) K09K1_34420 ENOG4107T0K Adenylate cyclase K09K1_34430 ENOG4105XQ6 frataxin-like protein K09K1_34440 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) K09K1_34450 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) K09K1_34470 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) K09K1_34480 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant K09K1_34490 ENOG4105BZU Histidine kinase K09K1_34500 ENOG4106IUH DTW domain containing protein K09K1_34530 ENOG4105DQF Hydrolase K09K1_34540 ENOG4108EUD Lysophospholipase K09K1_34550 ENOG410829K Lysine exporter protein (Lyse ygga) K09K1_34560 ENOG4105D58 Diguanylate phosphodiesterase K09K1_34570 ENOG41082YX Transcriptional regulator, arsr family K09K1_34580 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase K09K1_34660 ENOG41076UM multiple antibiotic resistance (MarC)-related protein K09K1_34680 ENOG4106H78 methyltransferase K09K1_34690 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K09K1_34700 ENOG4105CAK Cell division ATP-binding protein ftsE K09K1_34710 ENOG4105CRP Part of the ABC transporter FtsEX involved in K09K1_34720 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) K09K1_34730 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) K09K1_34740 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) K09K1_34750 ENOG4105X6C Flagellar basal body-associated protein FliL K09K1_34760 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) K09K1_34770 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) K09K1_34780 ENOG4105E55 glycerol-3-phosphate acyltransferase K09K1_34790 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) K09K1_34810 ENOG4107R73 Mate efflux family protein K09K1_34820 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) K09K1_34850 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) K09K1_34860 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) K09K1_34880 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) K09K1_35020 ENOG4105JIM Phosphatidylserine synthase K09K1_35040 ENOG4105D4A Cell wall formation (By similarity) K09K1_35050 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase K09K1_35060 ENOG4105CS9 pantothenic acid kinase K09K1_35110 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) K09K1_35120 ENOG4105PM1 preprotein translocase subunit SecE K09K1_35130 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) K09K1_35140 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) K09K1_35150 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) K09K1_35160 ENOG4108VZM 50s ribosomal protein L10 K09K1_35170 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) K09K1_35180 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) K09K1_35190 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) K09K1_35200 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor K09K1_35210 ENOG4105E09 nadh pyrophosphatase K09K1_35220 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) K09K1_35230 ENOG4108RG0 uracil-dna glycosylase K09K1_35240 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase K09K1_35250 ENOG4105R2J Conserved Protein K09K1_35290 ENOG4105C12 Phosphoribosylglycinamide synthetase K09K1_35300 ENOG4105DC1 bifunctional purine biosynthesis protein purh K09K1_35310 ENOG4105W1Y Transcriptional regulator K09K1_35320 ENOG4108M3R transcriptional activator CadC K09K1_35330 ENOG4105D5Q Arginine ornithine antiporter K09K1_35340 ENOG4105CXN decarboxylase K09K1_35440 ENOG4105C5H ABC transporter K09K1_35460 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) K09K1_35470 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) K09K1_35480 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) K09K1_35490 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase K09K1_35500 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein K09K1_35510 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) K09K1_35520 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) K09K1_35550 ENOG4105D8G Major Facilitator superfamily K09K1_35560 ENOG4105BZU Histidine kinase K09K1_35570 ENOG4105C9Q fumarate hydratase class II K09K1_35600 ENOG4107QN1 sodium solute K09K1_35620 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) K09K1_35640 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) K09K1_35650 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter K09K1_35660 ENOG4108IJ0 Aspartate ammonia-lyase K09K1_35670 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 K09K1_35680 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) K09K1_35700 ENOG4105E0F Histidine kinase K09K1_35710 ENOG4105E3W Two component transcriptional regulator (Winged helix family K09K1_35720 ENOG4108SPG Periplasmic Protein K09K1_35730 ENOG41076HS cation diffusion facilitator family transporter K09K1_35740 ENOG4105CTQ phosphohexokinase K09K1_35750 ENOG4107QI1 Mate efflux family protein K09K1_35760 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) K09K1_35770 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) K09K1_35790 ENOG4105KT7 mgtC SapB transporter K09K1_35800 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein K09K1_35810 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) K09K1_35830 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) K09K1_35840 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) K09K1_35850 ENOG4105E33 succinate dehydrogenase K09K1_35870 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) K09K1_35890 ENOG41062JF Transcriptional regulator K09K1_35910 ENOG41063SB peptidase K09K1_35920 ENOG4105D7W serine acetyltransferase K09K1_35930 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase K09K1_35940 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) K09K1_35950 ENOG4107YZP Rhodanese domain protein K09K1_35960 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) K09K1_35980 ENOG4105C8P )-transporter K09K1_35990 ENOG4105DJ4 phosphatidylserine decarboxylase K09K1_36000 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) K09K1_36010 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) K09K1_36140 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) K09K1_36160 ENOG4105K8N protein family UPF0079, ATPase K09K1_36170 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase K09K1_36180 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) K09K1_36190 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) K09K1_36200 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) K09K1_36210 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) K09K1_36220 ENOG4107QJR hflk protein K09K1_36230 ENOG4105EPW hflc protein K09K1_36250 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis K09K1_36260 ENOG4108UV7 flagellar protein motX K09K1_36270 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) K09K1_36280 ENOG4105KPV Transcriptional regulator K09K1_36290 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) K09K1_36300 ENOG4105C2N RNA methyltransferase TrmH family group 3 K09K1_36310 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) K09K1_36320 ENOG4105C31 Tryptophanyl-tRNA synthetase K09K1_36350 ENOG4105DDQ anthranilate synthase K09K1_36360 ENOG4105C8Y Acetylornithine aminotransferase K09K1_36380 ENOG4105C26 Dehydrogenase K09K1_36400 ENOG4107RYR Transcriptional regulator, Crp Fnr family K09K1_36410 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) K09K1_36420 ENOG4105YP7 UPF0270 protein K09K1_36430 ENOG4105DNZ Alpha Beta Hydrolase K09K1_36450 ENOG4105C5H ABC transporter K09K1_36460 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein K09K1_36490 ENOG4108YZY peptidylprolyl cis-trans isomerase K09K1_36500 ENOG4105D44 asparaginase K09K1_36510 ENOG41069P5 Protein slyX homolog K09K1_36530 ENOG4108V1T peptidylprolyl cis-trans isomerase K09K1_36540 ENOG4105WWK YheO domain protein K09K1_36550 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) K09K1_36560 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) K09K1_36580 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) K09K1_36590 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) K09K1_36600 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) K09K1_36610 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) K09K1_36620 ENOG4105W53 bacterioferritin-associated ferredoxin K09K1_36630 ENOG4108UQY Iron-storage protein K09K1_36640 ENOG4105C6K Malic enzyme K09K1_36650 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) K09K1_36660 ENOG4105C28 cystathionine K09K1_36670 ENOG4105CFH Aspartokinase K09K1_36680 ENOG4105SYT Methylenetetrahydrofolate reductase K09K1_36700 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) K09K1_36710 ENOG4105CWC Acetylornithine deacetylase K09K1_36720 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase K09K1_36730 ENOG4105CAS nag kinase K09K1_36740 ENOG4105CDH Citrulline--aspartate ligase K09K1_36750 ENOG4105CH7 arginosuccinase K09K1_36780 ENOG4107QN2 dihydrolipoyl dehydrogenase K09K1_36790 ENOG4105EHV domain protein K09K1_36800 ENOG4105C5Q Transcriptional regulator K09K1_36810 ENOG4108JQC penicillin-binding protein 1A K09K1_36860 ENOG4105E4G Type IV pilus K09K1_36870 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) K09K1_36880 ENOG4105D49 3-dehydroquinate synthase K09K1_36900 ENOG4105DFE Dna adenine methylase K09K1_36910 ENOG4105DJV ribulose-phosphate 3-epimerase K09K1_36920 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) K09K1_36930 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) K09K1_36940 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) K09K1_36950 ENOG4105K9Q Binds to the 23S rRNA (By similarity) K09K1_36970 ENOG4105CDU Replicative dna helicase K09K1_36980 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) K09K1_36990 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme K09K1_37000 ENOG4107QP8 phosphohexose isomerase K09K1_37020 ENOG4105MYN Zinc uptake regulation protein K09K1_37030 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) K09K1_37070 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) K09K1_37080 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) K09K1_37090 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) K09K1_37200 ENOG4105EEQ Na H antiporter K09K1_37210 ENOG4105C3R Methionine synthase K09K1_37220 ENOG4105CFH Aspartokinase K09K1_37230 ENOG4105C5R Aminotransferase K09K1_37270 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) K09K1_37280 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase K09K1_37290 ENOG41086KC Transcriptional regulator K09K1_37300 ENOG4108UUM single-stranded DNA-binding protein K09K1_37310 ENOG41062P1 Diguanylate cyclase phosphodiesterase K09K1_37380 ENOG4107QHF type ii secretion system protein e K09K1_37390 ENOG4105D7Q type ii secretion system K09K1_37410 ENOG4108VAU general secretion pathway protein G K09K1_37480 ENOG4105DFF Rod shape-determining protein mreb K09K1_37490 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) K09K1_37500 ENOG4105VQ7 Rod shape-determining protein MreD K09K1_37510 ENOG4108Z03 MAF-like protein K09K1_37520 ENOG4105C03 ribonuclease K09K1_37530 ENOG4105QD6 exported protein K09K1_37550 ENOG4105D1U peptidase U62 modulator of DNA gyrase K09K1_37560 ENOG4108IAB Phoh family K09K1_37570 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) K09K1_37580 ENOG4105K3M )-transporter K09K1_37590 ENOG4105D3G Pseudouridine synthase K09K1_37600 ENOG4105C5I Dehydrogenase K09K1_37610 ENOG4105N42 UPF0307 protein K09K1_37620 ENOG4105CMS peptidase U62, modulator of DNA gyrase K09K1_37630 ENOG4105CJW magnesium transporter K09K1_37640 ENOG41080Z8 PHOSPHOCARRIER protein K09K1_37650 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) K09K1_37660 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN K09K1_37670 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA K09K1_37680 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) K09K1_37690 ENOG4108IUZ ABC transporter K09K1_37700 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA K09K1_37720 ENOG4105C2X Arabinose 5-phosphate isomerase K09K1_37740 ENOG4105DHJ ABC, transporter K09K1_37750 ENOG4105CY3 ABC transporter, permease K09K1_37760 ENOG4107PE3 Mammalian cell entry related domain protein K09K1_37770 ENOG4105E3I toluene tolerance K09K1_37790 ENOG4105VFK BolA family K09K1_37800 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) K09K1_37810 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase K09K1_37820 ENOG4105KME endoribonuclease L-psp K09K1_37830 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) K09K1_37840 ENOG4105CXT aspartate transcarbamylase K09K1_37860 ENOG4105DBV ornithine carbamoyltransferase K09K1_37870 ENOG4105CEU Arginine dihydrolase K09K1_37900 ENOG4108MJ3 acetyltransferase K09K1_37920 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) K09K1_37930 ENOG4105MYG DNA polymerase iii, chi subunit K09K1_37940 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) K09K1_37950 ENOG4108M8S permease YjgP YjgQ family protein K09K1_37960 ENOG4108K5H permease YjgP YjgQ family protein K09K1_37980 ENOG4105EXU Membrane K09K1_37990 ENOG41061TZ Short-chain dehydrogenase reductase Sdr K09K1_38030 ENOG4105CK1 PTS System K09K1_38040 ENOG4105VCP PTS System K09K1_38050 ENOG4105F8D glycoside hydrolase family 4 K09K1_38060 ENOG410901P UPF0249 protein K09K1_38070 ENOG4105ETE Transcriptional regulator (LacI family K09K1_38080 ENOG4108ESY Metal dependent phosphohydrolase K09K1_38170 ENOG4105C26 Dehydrogenase K09K1_38230 ENOG4105C8Q Methyl-accepting chemotaxis K09K1_38320 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) K09K1_38330 ENOG4105CEN a g-specific adenine glycosylase K09K1_38340 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) K09K1_38360 ENOG4105CSV Glutaminase K09K1_38370 ENOG4105CSA Coproporphyrinogen iii oxidase K09K1_38380 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) K09K1_38400 ENOG4105VZ9 UPF0235 protein K09K1_38410 ENOG4108VIA integral membrane protein K09K1_38420 ENOG4105II7 pyrroline-5-carboxylate reductase K09K1_38430 ENOG4105DFA alanine racemase domain protein K09K1_38440 ENOG4105CZX twitching motility protein K09K1_38450 ENOG4105CZX twitching motility protein K09K1_38460 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) K09K1_38470 ENOG4108UJU UPF0301 protein K09K1_38480 ENOG4105D7Z glutathione synthase K09K1_38490 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) K09K1_38500 ENOG4105RWS endonuclease I K09K1_38510 ENOG4105GPY SprT protein K09K1_38530 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP K09K1_38540 ENOG4105CV1 Transketolase (EC 2.2.1.1) K09K1_38550 ENOG4108R4R Iron-regulated virulence regulatory protein K09K1_38560 ENOG4105D05 Receptor K09K1_38570 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase K09K1_38580 ENOG4105BZA Phosphoglycerate kinase K09K1_38590 ENOG4105D2N Aldolase K09K1_38600 ENOG4105D64 Mechanosensitive ion channel K09K1_38630 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) K09K1_38640 ENOG4105MPN Membrane K09K1_38650 ENOG4108JQ1 Dehydrogenase K09K1_38660 ENOG4105E66 phosphoriboisomerase A K09K1_38670 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase K09K1_38680 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) K09K1_38700 ENOG4105D0A hydroxylase K09K1_38710 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family K09K1_38740 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) K09K1_38750 ENOG4105Y75 tpr repeat protein K09K1_38770 ENOG4108IYU L-aspartate oxidase K09K1_38780 ENOG4105EMN RNA polymerase sigma factor K09K1_38820 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) K09K1_38830 ENOG4105C3F Signal peptidase i K09K1_38840 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) K09K1_38850 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) K09K1_38860 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) K09K1_38870 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) K09K1_38880 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) K09K1_38890 ENOG4105BZU Histidine kinase K09K1_38900 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) K09K1_38910 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) K09K1_38930 ENOG4105DXN mazG family K09K1_38940 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) K09K1_38950 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) K09K1_38960 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) K09K1_38970 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) K09K1_38980 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) K09K1_38990 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) K09K1_39000 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) K09K1_39010 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) K09K1_39030 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) K09K1_39040 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) K09K1_39050 ENOG4107TH8 cina domain protein K09K1_39060 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) K09K1_39070 ENOG4105Y3E Modulates RecA activity (By similarity) K09K1_39080 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) K09K1_39090 ENOG4105CFH Aspartokinase K09K1_39100 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) K09K1_39220 ENOG4107QSA Oxaloacetate decarboxylase K09K1_39230 ENOG4105D9Q decarboxylase (Beta subunit) K09K1_39250 ENOG4105W39 Membrane K09K1_39270 ENOG4105D9M gamma-glutamylcysteine synthetase K09K1_39300 ENOG4108JU6 CBS domain protein K09K1_39310 ENOG4106KVJ cytochrome C assembly protein K09K1_39320 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K09K1_39330 ENOG4105K5M 30s ribosomal protein S16 K09K1_39340 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) K09K1_39350 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) K09K1_39360 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) K09K1_39370 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) K09K1_39380 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) K09K1_39390 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) K09K1_39400 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) K09K1_39410 ENOG4105D7Q type ii secretion system K09K1_39420 ENOG4107QHF type ii secretion system protein e K09K1_39430 ENOG4105KHS type IV fimbrial pilin protein K09K1_39440 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase K09K1_39470 ENOG41073TP transcriptional regulator K09K1_39480 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) K09K1_39490 ENOG4107QSN dihydrolipoamide acetyltransferase K09K1_39500 ENOG4107QN2 dihydrolipoyl dehydrogenase K09K1_39510 ENOG410630P Transcriptional regulator K09K1_39520 ENOG4108UGV hypoxanthine phosphoribosyltransferase K09K1_39530 ENOG41077A9 carbonic anhydrase K09K1_39540 ENOG4105CHH sulfate transporter K09K1_39550 ENOG4105DA5 (ABC) transporter K09K1_39560 ENOG4105E3A (ABC) transporter K09K1_39570 ENOG4105D1S lipid A biosynthesis K09K1_39580 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) K09K1_39590 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) K09K1_39600 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K09K1_39610 ENOG4105DJ0 Poly(A) Polymerase K09K1_39620 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) K09K1_39630 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K09K1_39640 ENOG4105PW4 Sugar fermentation stimulation protein homolog K09K1_39650 ENOG4105CQ7 ATP-dependent helicase K09K1_39660 ENOG4105BZ4 penicillin-binding protein K09K1_39670 ENOG4105D78 K07001 NTE family protein K09K1_39680 ENOG4107QIJ Aconitate hydratase 2 K09K1_39690 ENOG4105XTV UPF0231 protein K09K1_39700 ENOG4108YZA Nitrogen regulatory protein pii K09K1_39740 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) K09K1_39750 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) K09K1_39780 ENOG4105E2D ec 3.2.1.52 K09K1_39790 ENOG4105RD7 BadF BadG BcrA BcrD K09K1_39810 ENOG4108JQ7 (ABC) transporter K09K1_39820 ENOG4105C3U ABC transporter K09K1_39830 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component K09K1_39850 ENOG4107QRA Extracellular solute-binding protein, family 5 K09K1_39860 ENOG4105BZU Histidine kinase K09K1_39870 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) K09K1_39880 ENOG4105F4G Membrane K09K1_39890 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase K09K1_39900 ENOG4108YX9 iron--sulfur cluster insertion protein erpA K09K1_39930 ENOG4105DR5 peptidase K09K1_39940 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) K09K1_39960 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase K09K1_39970 ENOG4107QE9 Inherit from COG: Membrane K09K1_39980 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) K09K1_39990 ENOG4105HBR Rna-binding protein K09K1_40000 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) K09K1_40010 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) K09K1_40020 ENOG4105EEI dihydropteroate synthase K09K1_40030 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) K09K1_40070 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) K09K1_40080 ENOG4105CHV Transcription elongation factor NusA K09K1_40090 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) K09K1_40100 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) K09K1_40110 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) K09K1_40120 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) K09K1_40130 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) K09K1_40160 ENOG4105C3S Mate efflux family protein K09K1_40170 ENOG4106RZ4 Peptidase U32 K09K1_40180 ENOG4105CFP Peptidase U32 K09K1_40190 ENOG4105BZU Histidine kinase K09K1_40200 ENOG4105XPQ lipid carrier protein K09K1_40210 ENOG4108YYD acetyltransferase K09K1_40250 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) K09K1_40270 ENOG4105EYA deoxyribonuclease K09K1_40280 ENOG4105D9N nucleoside K09K1_40290 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) K09K1_40300 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) K09K1_40310 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) K09K1_40320 ENOG4105D3A purine nucleoside phosphorylase DeoD-type K09K1_40340 ENOG4105EAC phosphoserine phosphatase K09K1_40360 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) K09K1_40370 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) K09K1_40380 ENOG4105ETT transcriptional Regulator, LysR family K09K1_40400 ENOG4108IQE Amp-dependent synthetase and ligase K09K1_40460 ENOG41086KC Transcriptional regulator K09K1_40480 ENOG41064T2 transcriptional regulator, lysR family K09K1_40490 ENOG4105CQ4 Transcriptional regulator K09K1_40530 ENOG4107RX3 Mg2 transporter protein cora family protein K09K1_40540 ENOG4105C6V Glycerol-3-phosphate dehydrogenase K09K1_40550 ENOG4105E98 transcriptional regulator DeoR family K09K1_40560 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) K09K1_40570 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) K09K1_40580 ENOG4105CXY transporter K09K1_40590 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase K09K1_40600 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) K09K1_40630 ENOG4105X2V dna damage-inducible protein K09K1_40640 ENOG4105EVZ LysR family transcriptional regulator K09K1_40660 ENOG4105E68 Sulfatase K09K1_40680 ENOG4105DVF Cytosine-specific methyltransferase K09K1_40770 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) K09K1_40780 ENOG4105DSY exodeoxyribonuclease V, gamma K09K1_40790 ENOG4107QKA exodeoxyribonuclease V beta K09K1_40800 ENOG4107QYX exodeoxyribonuclease v alpha K09K1_40820 ENOG4107QZM n-acetylglutamate synthase K09K1_40840 ENOG4105CA3 membrane-bound lytic murein transglycosylase K09K1_40850 ENOG4105CUZ uba thif-type nad fad binding protein K09K1_40860 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) K09K1_40870 ENOG4105BZU Histidine kinase K09K1_40880 ENOG4105C9B Cysteine desulfurase K09K1_40890 ENOG4107S0N DJ-1 family K09K1_40900 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) K09K1_40940 ENOG4105K6V RNA polymerase K09K1_40970 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) K09K1_40980 ENOG4105IEY (LipO)protein K09K1_40990 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) K09K1_41000 ENOG4105M85 Bola protein K09K1_41010 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) K09K1_41020 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) K09K1_41030 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) K09K1_41040 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) K09K1_41050 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) K09K1_41060 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) K09K1_41070 ENOG4105CJ2 (LipO)protein K09K1_41090 ENOG4105BZU Histidine kinase K09K1_41110 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) K09K1_41210 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) K09K1_41230 ENOG4105CHH sulfate transporter K09K1_41290 ENOG4108ZXE K09K1_41390 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) K09K1_41440 ENOG4105C9U ATP-dependent DNA helicase RecQ K09K1_41450 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) K09K1_41480 ENOG4105C8J )-transporter K09K1_41500 ENOG4105W1I UPF0253 protein K09K1_41520 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) K09K1_41530 ENOG4108R96 Methyltransferase, YaeB family K09K1_41540 ENOG4105NRA 50s ribosomal protein l31 type b K09K1_41550 ENOG4105CFC Transporter K09K1_41600 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase K09K1_41610 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) K09K1_41620 ENOG4108UPT UPF0178 protein K09K1_41670 ENOG4105WP7 tRNA pseudouridine synthase C K09K1_41680 ENOG4105DR9 pseudouridine synthase K09K1_41690 ENOG4108T8E UPF0325 protein K09K1_41700 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) K09K1_41710 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) K09K1_41720 ENOG4105CE9 30S ribosomal protein S2 K09K1_41730 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) K09K1_41740 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) K09K1_41750 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) K09K1_41760 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) K09K1_41770 ENOG4105KNE Phosphatidate cytidylyltransferase K09K1_41780 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) K09K1_41790 ENOG4105DZP Membrane-associated zinc metalloprotease K09K1_41810 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) K09K1_41820 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) K09K1_41830 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) K09K1_41840 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) K09K1_41850 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) K09K1_41860 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) K09K1_41870 ENOG4105C0B DNA polymerase III (alpha subunit) K09K1_41880 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) K09K1_41890 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) K09K1_41900 ENOG4105N7H Cytochrome K09K1_41910 ENOG4108YZA Nitrogen regulatory protein pii K09K1_41920 ENOG4107NA1 Endonuclease Exonuclease phosphatase K09K1_41940 ENOG4105E9H Lytic Murein transglycosylase K09K1_41950 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) K09K1_41960 ENOG4105D1A Methyltransferase K09K1_41970 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) K09K1_41980 ENOG4108JDX DNA polymerase iii, epsilon subunit K09K1_42040 ENOG4107QPN acyl-Coa dehydrogenase K09K1_42050 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) K09K1_42060 ENOG4105E7A Glutamine amidotransferase K09K1_42080 ENOG4108V3E phosphoribosylglycinamide formyltransferase K09K1_42090 ENOG4105CXB phosphoribosylaminoimidazole synthetase K09K1_42110 ENOG4105C2W permease K09K1_42140 ENOG4105CS1 NAD(P)H quinone oxidoreductase K09K1_42150 ENOG4105K89 arsenate reductase K09K1_42160 ENOG4105ERG peptidase m48, ste24p K09K1_42190 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K09K1_42220 ENOG4105VEQ Cold shock protein K09K1_42230 ENOG4107QM5 aconitate hydratase K09K1_42240 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) K09K1_42260 ENOG4107QJR hflk protein K09K1_42270 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) K09K1_42280 ENOG4105VEQ Cold shock protein K09K1_42330 ENOG4105VEQ Cold shock protein K09K1_42360 ENOG41090WB Transposase is3 is911 K09K1_42370 ENOG4105BZU Histidine kinase K09K1_42400 ENOG4105C4R Atp-dependent dna helicase K09K1_42420 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) K09K1_42470 ENOG4108NV9 Glycosyl Transferase K09K1_42510 ENOG4108MBX Secretion Protein K09K1_42520 ENOG4108JJA ABC, transporter K09K1_42550 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K09K1_42600 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K09K1_42630 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) K09K1_42660 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) K09K1_42670 ENOG4105KUZ arsenate reductase K09K1_42710 ENOG4105QZU Inner membrane protein YfeZ K09K1_42720 ENOG4105EZR dyp-type peroxidase family protein K09K1_42730 ENOG4105I03 Flagellin K09K1_42740 ENOG4105I03 Flagellin K09K1_42750 ENOG4105I03 Flagellin K09K1_42760 ENOG41063QE flagellar protein FlaG K09K1_42770 ENOG4107BRV flagellar capping protein K09K1_42790 ENOG4105MQ3 flagellar protein FliS K09K1_42800 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family K09K1_42810 ENOG4105BZU Histidine kinase K09K1_42820 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family K09K1_42830 ENOG4105VQ0 flagellar hook-basal body complex protein fliE K09K1_42840 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) K09K1_42850 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) K09K1_42870 ENOG4108JIR Flagellum-specific ATP synthase K09K1_42920 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) K09K1_42930 ENOG4105DD5 Flagellar motor switch protein K09K1_42940 ENOG4105VTB flagellar biosynthesis protein fliO K09K1_42950 ENOG4105CN7 Flagellar biosynthetic protein FliP K09K1_42960 ENOG4105VS8 Flagellar biosynthetic protein fliq K09K1_42970 ENOG4105D19 Role in flagellar biosynthesis (By similarity) K09K1_42980 ENOG4105D00 flagellar biosynthetic protein flhB K09K1_42990 ENOG4105D7B Flagellar biosynthesis protein flha K09K1_43000 ENOG4105FZW flagellar biosynthesis regulator FlhF K09K1_43010 ENOG4107R21 site-determining protein K09K1_43020 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) K09K1_43030 ENOG4108VYJ response regulator receiver protein K09K1_43040 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) K09K1_43050 ENOG4105CBS Chea signal transduction histidine kinase K09K1_43060 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) K09K1_43070 ENOG4107QJE Chromosome Partitioning Protein K09K1_43090 ENOG4108V3W Chemotaxis protein, CheW K09K1_43110 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) K09K1_43120 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) K09K1_43130 ENOG41060IM Heme exporter protein K09K1_43140 ENOG4105X3C heme exporter protein K09K1_43150 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) K09K1_43160 ENOG4105DA4 cytochrome c-type biogenesis protein K09K1_43170 ENOG4107QX9 Thiol disulfide interChange protein K09K1_43180 ENOG4108M1T Cytochrome c-type biogenesis protein K09K1_43190 ENOG4105KWW Biogenesis protein K09K1_43200 ENOG410903C (LipO)protein K09K1_43210 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation K09K1_43220 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation K09K1_43260 ENOG4105CHU acetyl-coa acetyltransferase K09K1_43270 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase K09K1_43290 ENOG4107QXK peptidase K09K1_43300 ENOG4108BY2 phosphohistidine phosphatase K09K1_43310 ENOG4108DG9 Smr protein MutS2 K09K1_43320 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) K09K1_43330 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase K09K1_43340 ENOG4105EN6 Membrane K09K1_43350 ENOG4108BPE -transporting atpase K09K1_43360 ENOG4105MH2 YfcL protein K09K1_43370 ENOG4105Q8W reductase K09K1_43380 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) K09K1_43390 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) K09K1_43400 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) K09K1_43410 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) K09K1_43430 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) K09K1_43440 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) K09K1_43450 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase K09K1_43460 ENOG4108S3P Sporulation domain protein K09K1_43470 ENOG4105E96 Colicin v production protein K09K1_43480 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase K09K1_43490 ENOG4105EJC lysr family transcriptional regulator K09K1_43500 ENOG4105I93 response regulator K09K1_43520 ENOG4105WD1 Membrane K09K1_43530 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) K09K1_43540 ENOG4107QMP dna polymerase iii subunits gamma and tau K09K1_43550 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) K09K1_43560 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) K09K1_43570 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) K09K1_43580 ENOG4105KRS Proteinase inhibitor K09K1_43590 ENOG4105Y3U Transglycosylase-associated protein K09K1_43600 ENOG4108ZZ3 UPF0260 protein K09K1_43620 ENOG41067V3 Antibiotic biosynthesis monooxygenase K09K1_43650 ENOG4105G6Z alkaline phosphatase K09K1_43680 ENOG4105DHI Methyltransferase K09K1_43690 ENOG4107SDU Methyl-accepting chemotaxis K09K1_43700 ENOG4105DSB aldose 1-epimerase K09K1_43710 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase K09K1_43720 ENOG4105E0X reductase K09K1_43740 ENOG4105VUT cytoplasmic protein K09K1_43750 ENOG4105HDK L-asparaginase K09K1_43760 ENOG4105D07 Signal peptide peptidase, SppA K09K1_43770 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase K09K1_43790 ENOG41069NU Nitroreductase K09K1_43800 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) K09K1_43830 ENOG4108RU0 short-chain dehydrogenase reductase K09K1_43840 ENOG4105DGU Histone deacetylase K09K1_43860 ENOG4105E68 Sulfatase K09K1_43870 ENOG4105YDX UPF0352 protein K09K1_43880 ENOG4106V8H Nucleoid-associated protein K09K1_43910 ENOG4105DFD Na H antiporter K09K1_43920 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) K09K1_43930 ENOG4105EYW Ion transport protein K09K1_43940 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein K09K1_43950 ENOG4108EKI Dehydrogenase K09K1_43980 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) K09K1_43990 ENOG4105M2J Glutaredoxin K09K1_44030 ENOG4105D3Y Na H antiporter K09K1_44040 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) K09K1_44050 ENOG4105EIY sodium-type flagellar protein motY K09K1_44060 ENOG4106WH9 Protein of unknown function (DUF2753) K09K1_44070 ENOG4108UYE Lactoylglutathione lyase K09K1_44080 ENOG4105CSM endonuclease III K09K1_44090 ENOG4105DZB Electron transport complex K09K1_44100 ENOG4108UQQ Electron transport complex K09K1_44110 ENOG4105D6A Electron transport complex K09K1_44130 ENOG4108R3D Electron transport complex K09K1_44140 ENOG4105DGN Electron transport complex K09K1_44150 ENOG4105C6N Formate acetyltransferase K09K1_44170 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) K09K1_44180 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family K09K1_44200 ENOG4105CHW UPF0052 protein K09K1_44210 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) K09K1_44220 ENOG4108RIR Molybdenum cofactor biosynthesis protein K09K1_44230 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) K09K1_44240 ENOG4105M00 molybdopterin converting factor, subunit 1 K09K1_44250 ENOG4108ZAF Molybdopterin K09K1_44260 ENOG4107QSI ABC, transporter K09K1_44270 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component K09K1_44280 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component K09K1_44290 ENOG4105C3U ABC transporter K09K1_44300 ENOG4108JQ7 (ABC) transporter K09K1_44310 ENOG4105CHF Glutathione S-transferase K09K1_44330 ENOG4108DNC Involved in acetate metabolism (By similarity) K09K1_44340 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) K09K1_44350 ENOG4105PQ6 UPF0208 membrane protein K09K1_44370 ENOG4105C7J ABC transporter, permease K09K1_44380 ENOG4108JJB ABC transporter K09K1_44390 ENOG4107R28 alpha amylase, catalytic region K09K1_44400 ENOG4105BZU Histidine kinase K09K1_44410 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) K09K1_44420 ENOG4106RHG Yeca family K09K1_44430 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) K09K1_44450 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) K09K1_44490 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) K09K1_44500 ENOG4105D1F ATP-binding protein K09K1_44510 ENOG4105DBI uridine monophosphokinase K09K1_44530 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase K09K1_44550 ENOG4105CHH sulfate transporter K09K1_44560 ENOG4105C03 ribonuclease K09K1_44570 ENOG4105EI2 Pseudouridine synthase K09K1_44580 ENOG4108UHJ MAF-like protein K09K1_44590 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein K09K1_44600 ENOG4105VGS 50s ribosomal protein l32 K09K1_44610 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) K09K1_44620 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) K09K1_44630 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase K09K1_44640 ENOG4105CHR reductase K09K1_44650 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) K09K1_44660 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) K09K1_44680 ENOG4105HHA aminodeoxychorismate lyase K09K1_44690 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) K09K1_44700 ENOG4107QRG dna polymerase iii K09K1_44710 ENOG4105F8V Hydrolase, tatD family K09K1_44720 ENOG4105CI1 PTS System K09K1_44750 ENOG4105C8J )-transporter K09K1_44780 ENOG4108NRW Phospholipase, patatin family K09K1_44800 ENOG4105CA9 Pyruvate kinase K09K1_44810 ENOG4105DAG ROK family K09K1_44820 ENOG4107R88 Chemotaxis protein (CheV) K09K1_44830 ENOG4105C0B DNA polymerase III (alpha subunit) K09K1_44860 ENOG4105UBK short-chain dehydrogenase reductase K09K1_44870 ENOG4105ERU peptidase K09K1_44880 ENOG4105CAT Cytidine monophosphate kinase K09K1_44890 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) K09K1_44900 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) K09K1_44910 ENOG4105Q4A inner membrane protein yciS K09K1_44920 ENOG4105CFV Tetratricopeptide repeat protein K09K1_44930 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) K09K1_44940 ENOG4108J59 Extracellular solute-binding protein, family 5 K09K1_44980 ENOG4105DY2 Paraquat-inducible protein b K09K1_44990 ENOG4105F1S paraquat-inducible protein a K09K1_45000 ENOG4105NQN cytochrome C K09K1_45020 ENOG4105DB1 molybdopterin oxidoreductase K09K1_45030 ENOG4106WHD Tetrathionate reductase K09K1_45040 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein K09K1_45050 ENOG4106AFQ Histidine kinase K09K1_45060 ENOG4108ZXC Two component transcriptional regulator, luxr family K09K1_45080 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) K09K1_45090 ENOG4105N6Y Thioredoxin K09K1_45110 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) K09K1_45140 ENOG4105DJY efflux transporter, rnd family, mfp subunit K09K1_45160 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) K09K1_45170 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) K09K1_45180 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) K09K1_45220 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) K09K1_45240 ENOG4105J12 Multidrug resistance protein mdtN K09K1_45250 ENOG4105JQN Transcriptional regulator K09K1_45280 ENOG41062D9 Histidine kinase K09K1_45290 ENOG4105CK6 Two component transcriptional regulator (Winged helix family K09K1_45310 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) K09K1_45350 ENOG4105CCT upf0313 protein K09K1_45390 ENOG4105DZ2 Transcriptional regulator K09K1_45400 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) K09K1_45420 ENOG4105K9H YciI-like protein K09K1_45430 ENOG4105NAU thioesterase Superfamily protein K09K1_45440 ENOG4107835 probably involved in intracellular septation (By similarity) K09K1_45460 ENOG4105BZU Histidine kinase K09K1_45480 ENOG4105CK2 sodium dicarboxylate symporter K09K1_45490 ENOG4105CEY Amp-dependent synthetase and ligase K09K1_45500 ENOG4105DS0 Transcriptional regulator, Crp Fnr family K09K1_45510 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) K09K1_45520 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) K09K1_45530 ENOG4105DK0 Indole-3-glycerol phosphate synthase K09K1_45540 ENOG4108I0Q anthranilate phosphoribosyltransferase K09K1_45550 ENOG4105DDQ anthranilate synthase K09K1_45560 ENOG4105CRQ synthase (Component I) K09K1_45580 ENOG4105DB7 PHP domain protein K09K1_45590 ENOG4107RTD sua5 ycio yrdc ywlc family protein K09K1_45610 ENOG4105FE9 pseudouridine synthase K09K1_45620 ENOG4108W5H UPF0263 protein K09K1_45650 ENOG4105CQ2 DNA polymerase K09K1_45660 ENOG4105WH1 Two component transcriptional regulator luxr family K09K1_45670 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) K09K1_45750 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) K09K1_45800 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) K09K1_45810 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) K09K1_45820 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) K09K1_45830 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) K09K1_45860 ENOG4105EAU Plays a role in nitrite reduction (By similarity) K09K1_45880 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein K09K1_45890 ENOG4105DVI reductase, NrfD K09K1_45900 ENOG4105DA4 cytochrome c-type biogenesis protein K09K1_45910 ENOG4107QX9 Thiol disulfide interChange protein K09K1_45920 ENOG4108DMF Cytochrome C biogenesis protein K09K1_45930 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) K09K1_45980 ENOG4105DIT ErfK YbiS YcfS YnhG family protein K09K1_45990 ENOG4105EAQ (twin-arginine translocation) pathway signal K09K1_46000 ENOG4105C5X domain protein K09K1_46030 ENOG4105CH5 extracellular solute-binding protein, family 7 K09K1_46050 ENOG4105CG6 trap dicarboxylate transporter dctm subunit K09K1_46090 ENOG4105C94 Transporter K09K1_46100 ENOG4105C8Q Methyl-accepting chemotaxis K09K1_46140 ENOG4105CGF Aromatic amino acid aminotransferase K09K1_46170 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family K09K1_46190 ENOG4105C5S asparaginyl-tRNA synthetase K09K1_46200 ENOG4105C8Q Methyl-accepting chemotaxis K09K1_46210 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase K09K1_46230 ENOG4105BZU Histidine kinase K09K1_46240 ENOG4105EJQ L-serine dehydratase K09K1_46250 ENOG4105C44 Serine transporter K09K1_46260 ENOG4105P8F nudix hydrolase K09K1_46290 ENOG4105CRQ synthase (Component I) K09K1_46320 ENOG4105CM6 amino acid regulated cytosolic protein K09K1_46330 ENOG4106K28 UPF0283 membrane protein K09K1_46350 ENOG4105D9U N-acetyltransferase K09K1_46410 ENOG4105VYA Uncharacterized conserved protein (DUF2132) K09K1_46540 ENOG4105D3W isochorismatase K09K1_46630 ENOG4108YX2 DNA-binding protein K09K1_46660 ENOG4108WQH regulatoR K09K1_46670 ENOG4105BZU Histidine kinase K09K1_46770 ENOG4105UYK outer membrane protein a K09K1_46830 ENOG4108WQH regulatoR K09K1_46840 ENOG4105BZU Histidine kinase K09K1_46850 ENOG4105R3P Inner membrane protein yagU K09K1_46900 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family K09K1_46990 ENOG4105BZU Histidine kinase K09K1_47000 ENOG4105N1P Ferredoxin-type protein K09K1_47010 ENOG4108NEM leader-binding protein dmsD K09K1_47020 ENOG4107QY8 reductase K09K1_47030 ENOG4105QAX Iron-sulfur K09K1_47040 ENOG4107KGK dmso reductase anchor subunit K09K1_47080 ENOG4107SUZ Sodium/hydrogen exchanger family K09K1_47090 ENOG4105D0C transport protein K09K1_47110 ENOG4107QHE Choloylglycine hydrolase K09K1_47130 ENOG4105J12 Multidrug resistance protein mdtN K09K1_47140 ENOG4108MI0 Resistance protein K09K1_47170 ENOG4105EWV Sodium calcium exchanger membrane region K09K1_47180 ENOG4105EWV Sodium calcium exchanger membrane region K09K1_47200 ENOG4107QUT magnesium and cobalt transport protein CorA K09K1_47210 ENOG4105CVK Glutamate decarboxylase K09K1_47220 ENOG4105D0C transport protein K09K1_47250 ENOG4105BZU Histidine kinase K09K1_47410 ENOG4108R4U Hnh endonuclease K09K1_47580 ENOG4105EWC Purine nucleoside phosphorylase K09K1_47710 ENOG4108UW5 maltose o-acetyltransferase K09K1_47720 ENOG4105KNA -acetyltransferase K09K1_47730 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) K09K1_47770 ENOG4105KCV RNA signal recognition particle 4.5S RNA K09K1_47790 ENOG4105N14 lysine exporter protein LysE YggA K09K1_47800 ENOG41090VV Protein of unknown function (DUF2846) K09K1_47810 ENOG4105CFU surface antigen K09K1_47840 ENOG4105EBR Carboxylesterase K09K1_47880 ENOG4105Y49 secretion protein, HlyD family K09K1_47900 ENOG4105D0C transport protein K09K1_47910 ENOG4105CEB Aspartate aminotransferase K09K1_47920 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) K09K1_47950 ENOG4105DUM transcriptional regulator, lysR family K09K1_47980 ENOG4107KET secretion protein, HlyD family K09K1_48010 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism K09K1_48020 ENOG4106YYS transcriptional regulatory protein K09K1_48050 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase K09K1_48060 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) K09K1_48070 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) K09K1_48100 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family K09K1_48110 ENOG4105C26 Dehydrogenase K09K1_48150 ENOG4108KB1 transcriptional regulator, arac family K09K1_48210 ENOG41066XE Type III export protein K09K1_48350 ENOG4105E7U AraC family transcriptional regulator K09K1_48570 ENOG4105EJ9 Membrane K09K1_48640 ENOG4105CR4 methylisocitrate lyase K09K1_48650 ENOG4105BZN citrate synthase K09K1_48660 ENOG4108I0Z Aconitate hydratase K09K1_48670 ENOG4105C7F AcnD-accessory protein PrpF K09K1_48680 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) K09K1_48700 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap K09K1_48720 ENOG410667J hydrolase K09K1_48730 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) K09K1_48740 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) K09K1_48770 ENOG41090KR LysR family transcriptional Regulator K09K1_48790 ENOG4105HEI LysR family (Transcriptional regulator K09K1_48820 ENOG4105CC0 LysR family Transcriptional regulator K09K1_48860 ENOG4106PMH Extracellular solute-binding protein family 3 K09K1_48870 ENOG4105EAD ABC transporter K09K1_48880 ENOG4105CDA abc transporter atp-binding protein K09K1_48890 ENOG4105C3R Methionine synthase K09K1_48900 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein K09K1_48920 ENOG4106PMH Extracellular solute-binding protein family 3 K09K1_48930 ENOG4108W2Y isochorismatase K09K1_48940 ENOG41063TF transcriptional regulator (AraC K09K1_48970 ENOG4105F27 Major Facilitator K09K1_48980 ENOG4105HEI LysR family (Transcriptional regulator K09K1_49000 ENOG4105HEI LysR family (Transcriptional regulator K09K1_49010 ENOG4105CV8 reductase K09K1_49030 ENOG4107HP6 Transcriptional regulator K09K1_49040 ENOG4105BZU Histidine kinase K09K1_49060 ENOG4105CDV Ompa motb domain protein K09K1_49090 ENOG4105KCK Peptidoglycan-associated lipoprotein K09K1_49120 ENOG4105DR4 Methyltransferase K09K1_49130 ENOG4105C8Q Methyl-accepting chemotaxis K09K1_49140 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 K09K1_49150 ENOG4108Z0T Part of a sulfur-relay system (By similarity) K09K1_49170 ENOG4108MN8 Membrane K09K1_49180 ENOG4105CDA abc transporter atp-binding protein K09K1_49190 ENOG4105DRP amino acid AbC transporter K09K1_49200 ENOG4105EZ7 amino acid ABC transporter K09K1_49220 ENOG4107QXX ABC transporter K09K1_49240 ENOG4108VPT UPF0234 protein K09K1_49250 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) K09K1_49290 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B K09K1_49300 ENOG4105DY2 Paraquat-inducible protein b K09K1_49310 ENOG4105H2K paraquat-inducible protein a K09K1_49320 ENOG4105BZ1 (ABC) transporter K09K1_49330 ENOG4108ZGC gaf domain protein K09K1_49340 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) K09K1_49350 ENOG4105CN1 protease K09K1_49370 ENOG4105CD8 aminopeptidase N K09K1_49380 ENOG4105C7I Dehydrogenase K09K1_49390 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) K09K1_49400 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) K09K1_49410 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) K09K1_49430 ENOG4105C5H ABC transporter K09K1_49460 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) K09K1_49470 ENOG4105DAN ATP-dependent protease K09K1_49480 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) K09K1_49530 ENOG4105MQ5 zona occludens toxin