locus-tag	class	description
K10K4_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K10K4_00020	COG0592	DNA-directed DNA polymerase activity
K10K4_00040	COG0187	DNA topoisomerase II activity
K10K4_00070	COG0071	Belongs to the small heat shock protein (HSP20) family
K10K4_00080	COG3977	Valine--pyruvate aminotransferase
K10K4_00090	COG0366	Alpha amylase catalytic
K10K4_00120	COG2119	membrane
K10K4_00140	COG0425	Belongs to the sulfur carrier protein TusA family
K10K4_00170	COG0604	alcohol dehydrogenase
K10K4_00180	COG0183	Belongs to the thiolase family
K10K4_00200	COG1739	Uncharacterized protein family UPF0029
K10K4_00210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K10K4_00290	COG0583	DNA-binding transcription factor activity
K10K4_00300	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K10K4_00310	COG2960	long-chain fatty acid transporting porin activity
K10K4_00320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K10K4_00330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K10K4_00430	COG4172	Belongs to the ABC transporter superfamily
K10K4_00440	COG4166	transmembrane transport
K10K4_00460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K10K4_00480	COG1609	Transcriptional regulator
K10K4_00490	COG0583	DNA-binding transcription factor activity
K10K4_00510	COG2076	Multidrug Resistance protein
K10K4_00520	COG0129	dihydroxy-acid dehydratase activity
K10K4_00530	COG3265	gluconokinase activity
K10K4_00540	COG2610	gluconate transmembrane transporter activity
K10K4_00550	COG0800	Aldolase
K10K4_00560	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K10K4_00570	COG0583	DNA-binding transcription factor activity
K10K4_00580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K10K4_00590	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K10K4_00610	COG1522	sequence-specific DNA binding
K10K4_00620	COG5002	protein histidine kinase activity
K10K4_00620	COG5001	Diguanylate cyclase
K10K4_00630	COG0742	ribosomal rna small subunit methyltransferase
K10K4_00650	COG0697	spore germination
K10K4_00660	COG0589	response to stress
K10K4_00670	COG1528	Iron-storage protein
K10K4_00690	COG2081	HI0933 family
K10K4_00750	COG1597	lipid kinase activity
K10K4_00810	COG0628	permease
K10K4_00840	COG1322	Protein conserved in bacteria
K10K4_00850	COG2226	methyltransferase
K10K4_00860	COG3165	ubiquinone biosynthetic process from chorismate
K10K4_00870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K10K4_00900	COG0805	protein transport
K10K4_00910	COG0084	hydrolase, TatD family'
K10K4_00930	COG0456	acetyltransferase
K10K4_00950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K10K4_00950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K10K4_00960	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K10K4_01010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K10K4_01020	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K10K4_01040	COG2204	response regulator
K10K4_01050	COG3852	Histidine kinase
K10K4_01070	COG0174	glutamine synthetase
K10K4_01090	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K10K4_01110	COG1295	ribonuclease BN
K10K4_01120	COG1490	D-aminoacyl-tRNA deacylase activity
K10K4_01130	COG0456	acetyltransferase
K10K4_01150	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K10K4_01160	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K10K4_01170	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K10K4_01180	COG3031	protein transport across the cell outer membrane
K10K4_01200	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K10K4_01210	COG1459	type II secretion system
K10K4_01220	COG2165	general secretion pathway protein
K10K4_01230	COG2165	general secretion pathway protein
K10K4_01240	COG2165	general secretion pathway protein
K10K4_01250	COG4795	General secretion pathway protein
K10K4_01260	COG3156	type II secretion system protein K
K10K4_01270	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K10K4_01280	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K10K4_01300	COG1218	3'(2'),5'-bisphosphate nucleotidase
K10K4_01310	COG0494	nUDIX hydrolase
K10K4_01330	COG1040	competence protein
K10K4_01360	COG2183	response to ionizing radiation
K10K4_01380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K10K4_01400	COG0745	RESPONSE REGULATOR receiver
K10K4_01410	COG2205	protein histidine kinase activity
K10K4_01420	COG2233	PERMEase
K10K4_01430	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K10K4_01440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K10K4_01450	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K10K4_01460	COG1758	RNA polymerase activity
K10K4_01470	COG0194	GDP metabolic process
K10K4_01500	COG0848	biopolymer transport protein
K10K4_01510	COG0811	peptide transport
K10K4_01550	COG4174	ABC transporter (Permease)
K10K4_01560	COG4239	(ABC) transporter, permease
K10K4_01570	COG0747	negative chemotaxis
K10K4_01580	COG0444	Belongs to the ABC transporter superfamily
K10K4_01590	COG4608	Belongs to the ABC transporter superfamily
K10K4_01610	COG1561	YicC-like family, N-terminal region
K10K4_01620	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K10K4_01630	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K10K4_01640	COG1560	Kdo2-lipid A biosynthetic process
K10K4_01650	COG1309	transcriptional regulator
K10K4_01660	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K10K4_01680	COG2003	Belongs to the UPF0758 family
K10K4_01730	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K10K4_01760	COG0463	Glycosyl transferase, family 2
K10K4_01770	COG0859	PFAM glycosyl transferase family 9
K10K4_01780	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K10K4_01790	COG3642	lipopolysaccharide core region biosynthetic process
K10K4_01810	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K10K4_01890	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K10K4_01900	COG1519	Transferase
K10K4_01910	COG0859	PFAM glycosyl transferase family 9
K10K4_01930	COG1560	Kdo2-lipid A biosynthetic process
K10K4_01970	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K10K4_02070	COG0438	transferase activity, transferring glycosyl groups
K10K4_02090	COG0297	glycogen (starch) synthase activity
K10K4_02090	COG0438	transferase activity, transferring glycosyl groups
K10K4_02110	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K10K4_02120	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K10K4_02130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K10K4_02190	COG1215	transferase activity, transferring glycosyl groups
K10K4_02240	COG0149	triose-phosphate isomerase activity
K10K4_02290	COG1494	fructose-1,6-bisphosphatase
K10K4_02310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K10K4_02320	COG1575	Belongs to the MenA family. Type 1 subfamily
K10K4_02380	COG2003	Belongs to the UPF0758 family
K10K4_02410	COG4565	transcriptional regulatory protein
K10K4_02430	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K10K4_02440	COG5016	pyruvate
K10K4_02440	COG0511	ligase activity, forming carbon-carbon bonds
K10K4_02450	COG3630	sodium ion export across plasma membrane
K10K4_02470	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
K10K4_02480	COG3052	prosthetic group binding
K10K4_02490	COG2301	Belongs to the HpcH HpaI aldolase family
K10K4_02500	COG3051	citrate lyase alpha subunit
K10K4_02510	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
K10K4_02520	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
K10K4_02550	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K10K4_02560	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K10K4_02590	COG1609	Transcriptional regulator
K10K4_02600	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K10K4_02610	COG0254	rRNA binding
K10K4_02630	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K10K4_02640	COG0088	Forms part of the polypeptide exit tunnel
K10K4_02660	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K10K4_02670	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K10K4_02680	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K10K4_02690	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K10K4_02710	COG0255	Belongs to the universal ribosomal protein uL29 family
K10K4_02720	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K10K4_02740	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K10K4_02750	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K10K4_02760	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K10K4_02770	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K10K4_02780	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K10K4_02810	COG1841	ribosomal large subunit assembly
K10K4_02830	COG0201	protein transport
K10K4_02850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K10K4_02860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K10K4_02880	COG0202	RNA polymerase activity
K10K4_02890	COG0203	ribosomal protein L17
K10K4_02910	COG0545	Peptidyl-prolyl cis-trans isomerase
K10K4_02930	COG2153	protein acetylation
K10K4_02940	COG0513	Belongs to the DEAD box helicase family
K10K4_02970	COG1648	precorrin-2 dehydrogenase activity
K10K4_02970	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K10K4_02980	COG0175	sulfate reduction
K10K4_02990	COG2895	sulfate adenylyltransferase (ATP) activity
K10K4_03000	COG3273	potassium ion transport
K10K4_03000	COG0471	metal ion transport
K10K4_03010	COG0529	Catalyzes the synthesis of activated sulfate
K10K4_03060	COG4181	ATPase activity
K10K4_03090	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K10K4_03110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K10K4_03120	COG0729	surface antigen
K10K4_03130	COG2911	Protein conserved in bacteria
K10K4_03140	COG2105	PFAM AIG2 family protein
K10K4_03160	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K10K4_03170	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K10K4_03180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K10K4_03190	COG0163	prenyltransferase activity
K10K4_03200	COG4143	(ABC) transporter
K10K4_03210	COG1178	ABC-type Fe3 transport system permease component
K10K4_03220	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K10K4_03230	COG0583	DNA-binding transcription factor activity
K10K4_03240	COG1902	pentaerythritol trinitrate reductase activity
K10K4_03310	COG0142	geranyltranstransferase activity
K10K4_03320	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K10K4_03340	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K10K4_03350	COG2966	Psort location CytoplasmicMembrane, score
K10K4_03370	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K10K4_03380	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K10K4_03390	COG2967	ApaG domain
K10K4_03400	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K10K4_03410	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K10K4_03420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K10K4_03430	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K10K4_03440	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K10K4_03480	COG0473	3-isopropylmalate dehydrogenase activity
K10K4_03490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K10K4_03530	COG0583	DNA-binding transcription factor activity
K10K4_03540	COG1022	Amp-dependent synthetase and ligase
K10K4_03550	COG0028	Belongs to the TPP enzyme family
K10K4_03560	COG0440	acetolactate synthase activity
K10K4_03570	COG3706	GGDEF domain
K10K4_03590	COG0469	pyruvate kinase activity
K10K4_03600	COG1349	DNA-binding transcription factor activity
K10K4_03610	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K10K4_03630	COG2376	Dihydroxyacetone kinase
K10K4_03640	COG1461	Dihydroxyacetone kinase
K10K4_03670	COG3722	fumarate hydratase activity
K10K4_03690	COG2213	PTS system mannitol-specific
K10K4_03690	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K10K4_03750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K10K4_03760	COG0358	DNA primase activity
K10K4_03770	COG1610	YqeY-like protein
K10K4_03780	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K10K4_03790	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K10K4_03800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K10K4_03810	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K10K4_03820	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K10K4_03830	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K10K4_03840	COG1968	undecaprenyl-diphosphatase activity
K10K4_03860	COG3409	Peptidoglycan-binding domain 1 protein
K10K4_03860	COG3267	Type II secretory pathway component ExeA
K10K4_03880	COG0405	Gamma-glutamyltransferase
K10K4_03890	COG4991	sh3 domain protein
K10K4_03900	COG0306	phosphate transporter
K10K4_03910	COG1392	Phosphate transport regulator
K10K4_03920	COG3025	triphosphatase activity
K10K4_03950	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K10K4_03960	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K10K4_03960	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K10K4_03970	COG1538	Outer membrane efflux protein
K10K4_03980	COG0494	nUDIX hydrolase
K10K4_03990	COG3151	Protein conserved in bacteria
K10K4_04010	COG3150	esterase
K10K4_04020	COG0187	DNA topoisomerase II activity
K10K4_04030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K10K4_04040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K10K4_04060	COG3105	Protein conserved in bacteria
K10K4_04070	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K10K4_04090	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K10K4_04100	COG0723	plastoquinol--plastocyanin reductase activity
K10K4_04110	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K10K4_04120	COG2857	Cytochrome c1
K10K4_04130	COG0625	glutathione transferase activity
K10K4_04140	COG2969	positive regulation of protein catabolic process
K10K4_04170	COG2823	Periplasmic or secreted lipoprotein
K10K4_04180	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K10K4_04210	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K10K4_04230	COG3116	cell division
K10K4_04240	COG0768	penicillin binding
K10K4_04250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K10K4_04260	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K10K4_04270	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K10K4_04280	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K10K4_04290	COG0772	Belongs to the SEDS family
K10K4_04320	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K10K4_04330	COG0849	cell division
K10K4_04340	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K10K4_04350	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K10K4_04370	COG0653	protein targeting
K10K4_04380	COG0494	nUDIX hydrolase
K10K4_04400	COG0505	Belongs to the CarA family
K10K4_04410	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K10K4_04440	COG0730	response to heat
K10K4_04450	COG0583	DNA-binding transcription factor activity
K10K4_04460	COG2860	membrane
K10K4_04490	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K10K4_04510	COG0493	'glutamate synthase
K10K4_04520	COG0070	glutamate synthase
K10K4_04520	COG0067	glutamate synthase
K10K4_04520	COG0069	glutamate synthase activity
K10K4_04540	COG0067	glutamate synthase
K10K4_04540	COG0070	glutamate synthase
K10K4_04540	COG0069	glutamate synthase activity
K10K4_04550	COG1242	4 iron, 4 sulfur cluster binding
K10K4_04560	COG5001	Diguanylate cyclase
K10K4_04560	COG4251	negative regulation of phosphorylation
K10K4_04560	COG3706	GGDEF domain
K10K4_04560	COG2203	Gaf domain
K10K4_04570	COG5002	protein histidine kinase activity
K10K4_04570	COG2198	Histidine kinase
K10K4_04570	COG0784	Response regulator, receiver
K10K4_04590	COG0745	RESPONSE REGULATOR receiver
K10K4_04610	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K10K4_04640	COG0083	homoserine kinase activity
K10K4_04650	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K10K4_04670	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
K10K4_04680	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K10K4_04690	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K10K4_04720	COG1115	amino acid carrier protein
K10K4_04730	COG3022	response to hydroperoxide
K10K4_04740	COG0513	Belongs to the DEAD box helicase family
K10K4_04750	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K10K4_04770	COG0716	FMN binding
K10K4_04790	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K10K4_04800	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K10K4_04810	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K10K4_04830	COG2204	response regulator
K10K4_04860	COG0667	Aldo Keto reductase
K10K4_04910	COG0730	response to heat
K10K4_04930	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K10K4_04950	COG1283	sodium-dependent phosphate transmembrane transporter activity
K10K4_04960	COG0583	DNA-binding transcription factor activity
K10K4_04970	COG0640	Transcriptional regulator
K10K4_04980	COG0268	Binds directly to 16S ribosomal RNA
K10K4_04990	COG0728	peptidoglycan biosynthetic process
K10K4_05000	COG0196	riboflavin kinase activity
K10K4_05030	COG1047	Peptidyl-prolyl cis-trans
K10K4_05040	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K10K4_05060	COG3279	Response regulator of the LytR AlgR family
K10K4_05070	COG3275	phosphorelay sensor kinase activity
K10K4_05080	COG1966	Carbon starvation protein
K10K4_05120	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K10K4_05130	COG1472	Belongs to the glycosyl hydrolase 3 family
K10K4_05140	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K10K4_05150	COG1605	Chorismate mutase
K10K4_05150	COG0287	Prephenate dehydrogenase
K10K4_05160	COG0739	heme binding
K10K4_05180	COG0488	(ABC) transporter
K10K4_05200	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
K10K4_05210	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
K10K4_05220	COG1605	Chorismate mutase
K10K4_05220	COG0077	Prephenate dehydratase
K10K4_05230	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K10K4_05250	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K10K4_05260	COG0564	pseudouridine synthase activity
K10K4_05280	COG0542	response to heat
K10K4_05400	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K10K4_05420	COG2974	May be involved in recombination
K10K4_05430	COG0745	RESPONSE REGULATOR receiver
K10K4_05440	COG5002	protein histidine kinase activity
K10K4_05460	COG0248	Ppx GppA phosphatase
K10K4_05470	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K10K4_05480	COG0573	inorganic phosphate transmembrane transporter activity
K10K4_05490	COG0581	inorganic phosphate transmembrane transporter activity
K10K4_05500	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K10K4_05510	COG0704	Plays a role in the regulation of phosphate uptake
K10K4_05530	COG3142	Participates in the control of copper homeostasis
K10K4_05540	COG0450	alkyl hydroperoxide reductase
K10K4_05550	COG0583	DNA-binding transcription factor activity
K10K4_05560	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K10K4_05580	COG0517	IMP dehydrogenase activity
K10K4_05600	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K10K4_05620	COG1862	Preprotein translocase
K10K4_05630	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K10K4_05640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K10K4_05670	COG0483	inositol monophosphate 1-phosphatase activity
K10K4_05680	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
K10K4_05700	COG1104	cysteine desulfurase activity
K10K4_05710	COG0822	iron-sulfur transferase activity
K10K4_05740	COG0443	Heat shock 70 kDa protein
K10K4_05750	COG0633	Ferredoxin
K10K4_05760	COG2975	iron-sulfur cluster assembly
K10K4_05780	COG0105	UTP biosynthetic process
K10K4_05810	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K10K4_05820	COG0124	histidyl-tRNA synthetase
K10K4_05830	COG2976	Protein conserved in bacteria
K10K4_05840	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K10K4_05850	COG1160	GTP binding
K10K4_05890	COG0517	IMP dehydrogenase activity
K10K4_05890	COG0516	GMP reductase activity
K10K4_05910	COG0582	viral genome integration into host DNA
K10K4_06050	COG1757	Na H antiporter
K10K4_06070	COG1584	GPR1 FUN34 yaaH family protein
K10K4_06080	COG1115	amino acid carrier protein
K10K4_06110	COG2873	o-acetylhomoserine
K10K4_06120	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K10K4_06160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K10K4_06160	COG3153	acetyltransferase
K10K4_06170	COG0583	DNA-binding transcription factor activity
K10K4_06210	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K10K4_06220	COG2867	negative regulation of translational initiation
K10K4_06230	COG2914	Belongs to the UPF0125 (RnfH) family
K10K4_06240	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K10K4_06260	COG0497	DNA recombination
K10K4_06280	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K10K4_06290	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K10K4_06310	COG1301	dicarboxylic acid transport
K10K4_06330	COG0484	heat shock protein binding
K10K4_06390	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K10K4_06400	COG0590	tRNA wobble adenosine to inosine editing
K10K4_06410	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K10K4_06420	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K10K4_06420	COG0047	phosphoribosylformylglycinamidine synthase activity
K10K4_06480	COG2195	Cleaves the N-terminal amino acid of tripeptides
K10K4_06490	COG2252	PERMEase
K10K4_06500	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K10K4_06530	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K10K4_06540	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K10K4_06550	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K10K4_06560	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K10K4_06560	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K10K4_06610	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K10K4_06620	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K10K4_06630	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K10K4_06640	COG0142	geranyltranstransferase activity
K10K4_06650	COG1722	exodeoxyribonuclease VII activity
K10K4_06660	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K10K4_06680	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K10K4_06680	COG0301	tRNA thio-modification
K10K4_06690	COG0583	DNA-binding transcription factor activity
K10K4_06710	COG2363	Small membrane protein
K10K4_06730	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K10K4_06740	COG1611	Belongs to the LOG family
K10K4_06750	COG3706	GGDEF domain
K10K4_06750	COG0745	RESPONSE REGULATOR receiver
K10K4_06770	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K10K4_06770	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K10K4_06790	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
K10K4_06800	COG1464	Belongs to the NlpA lipoprotein family
K10K4_06810	COG2011	ABC-type metal ion transport system permease component
K10K4_06820	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K10K4_06830	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K10K4_06850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K10K4_06850	COG1263	PTS System
K10K4_06860	COG0366	Alpha amylase catalytic
K10K4_06890	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K10K4_06900	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K10K4_06910	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K10K4_06920	COG0321	lipoyl(octanoyl) transferase activity
K10K4_06940	COG1686	Belongs to the peptidase S11 family
K10K4_06950	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K10K4_06960	COG0772	Belongs to the SEDS family
K10K4_06970	COG0768	penicillin binding
K10K4_06980	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K10K4_06990	COG0799	negative regulation of ribosome biogenesis
K10K4_07000	COG1466	dna polymerase III delta subunit
K10K4_07010	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
K10K4_07020	COG0495	leucyl-tRNA aminoacylation
K10K4_07030	COG2888	peptidyl-tyrosine sulfation
K10K4_07040	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K10K4_07050	COG4535	Mg2 and Co2 transporter CorC
K10K4_07060	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K10K4_07070	COG1702	phosphate starvation-inducible protein PhoH
K10K4_07080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K10K4_07090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K10K4_07300	COG0012	GTP binding
K10K4_07310	COG0193	aminoacyl-tRNA hydrolase activity
K10K4_07320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K10K4_07330	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K10K4_07340	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K10K4_07350	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K10K4_07370	COG2890	protein-(glutamine-N5) methyltransferase activity
K10K4_07380	COG3094	Invasion gene expression up-regulator, SirB
K10K4_07390	COG2912	Transglutaminase-like superfamily
K10K4_07400	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K10K4_07410	COG0737	Belongs to the 5'-nucleotidase family
K10K4_07420	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K10K4_07430	COG1187	pseudouridine synthase activity
K10K4_07440	COG2840	Smr protein MutS2
K10K4_07520	COG2608	mercury ion transmembrane transporter activity
K10K4_07520	COG2217	Heavy metal translocating P-type atpase
K10K4_07540	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K10K4_07650	COG0784	Response regulator, receiver
K10K4_07650	COG0835	chemotaxis
K10K4_07660	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K10K4_07670	COG1815	bacterial-type flagellum-dependent cell motility
K10K4_07680	COG1558	bacterial-type flagellum-dependent cell motility
K10K4_07690	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K10K4_07700	COG1749	Flagellar hook protein flgE
K10K4_07710	COG4787	bacterial-type flagellum-dependent cell motility
K10K4_07720	COG4786	Flagellar basal body rod
K10K4_07730	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K10K4_07740	COG1706	bacterial-type flagellum-dependent cell motility
K10K4_07750	COG3951	Flagellar rod assembly protein muramidase FlgJ
K10K4_07750	COG1705	Flagellar rod assembly protein muramidase FlgJ
K10K4_07770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K10K4_07780	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K10K4_07790	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K10K4_07800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K10K4_07810	COG2190	(PTS) system
K10K4_07820	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K10K4_07840	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K10K4_07850	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K10K4_07860	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
K10K4_07870	COG3115	cell septum assembly
K10K4_07880	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K10K4_07930	COG0330	HflC and HflK could
K10K4_07940	COG2194	sulfuric ester hydrolase activity
K10K4_07980	COG1192	Involved in chromosome partitioning
K10K4_07990	COG1215	transferase activity, transferring glycosyl groups
K10K4_08010	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
K10K4_08020	COG0457	Tetratricopeptide repeat
K10K4_08020	COG3118	belongs to the thioredoxin family
K10K4_08030	COG3118	belongs to the thioredoxin family
K10K4_08040	COG0300	oxidoreductase activity
K10K4_08050	COG1090	epimerase
K10K4_08110	COG0622	Phosphoesterase
K10K4_08150	COG3710	Transcriptional regulator
K10K4_08160	COG0326	Molecular chaperone. Has ATPase activity
K10K4_08180	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K10K4_08190	COG3104	oligopeptide transport
K10K4_08200	COG0250	Participates in transcription elongation, termination and antitermination
K10K4_08210	COG0367	asparagine synthase
K10K4_08220	COG4651	solute:proton antiporter activity
K10K4_08220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K10K4_08230	COG1846	Transcriptional regulator
K10K4_08230	COG1940	carbohydrate kinase activity
K10K4_08240	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K10K4_08250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K10K4_08250	COG1263	PTS System
K10K4_08250	COG2190	(PTS) system
K10K4_08260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K10K4_08270	COG0735	belongs to the Fur family
K10K4_08290	COG0716	FMN binding
K10K4_08310	COG0596	Alpha beta hydrolase
K10K4_08320	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
K10K4_08330	COG0033	Phosphoglucomutase
K10K4_08350	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K10K4_08370	COG2009	succinate dehydrogenase
K10K4_08380	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K10K4_08390	COG1053	succinate dehydrogenase
K10K4_08400	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K10K4_08410	COG0567	Dehydrogenase, E1 component
K10K4_08420	COG0508	dehydrogenase complex catalyzes the overall conversion of
K10K4_08430	COG0045	succinate-CoA ligase (ADP-forming) activity
K10K4_08450	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K10K4_08460	COG1121	(ABC) transporter
K10K4_08470	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
K10K4_08480	COG4977	sequence-specific DNA binding
K10K4_08490	COG1918	ferrous iron import across plasma membrane
K10K4_08540	COG0018	arginyl-trna synthetase
K10K4_08550	COG3102	Protein conserved in bacteria
K10K4_08580	COG0788	formyltetrahydrofolate deformylase activity
K10K4_08590	COG1199	ATP-dependent helicase activity
K10K4_08600	COG1214	PFAM Peptidase M22, glycoprotease
K10K4_08620	COG3065	identical protein binding
K10K4_08630	COG2267	carboxylic ester hydrolase activity
K10K4_08640	COG0318	PFAM AMP-dependent synthetase and ligase
K10K4_08650	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K10K4_08670	COG2894	cell division
K10K4_08680	COG0850	regulation of cytokinetic process
K10K4_08690	COG3100	YcgL domain-containing protein
K10K4_08700	COG2951	lytic endotransglycosylase activity
K10K4_08720	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K10K4_08730	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K10K4_08750	COG2226	methyltransferase
K10K4_08770	COG1028	Short-chain dehydrogenase reductase Sdr
K10K4_08780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K10K4_08790	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K10K4_08840	COG2986	histidine ammonia-lyase
K10K4_08850	COG1216	Glycosyl transferase, family 2
K10K4_08860	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K10K4_08890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K10K4_08900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K10K4_08970	COG0513	Belongs to the DEAD box helicase family
K10K4_08980	COG0569	domain protein
K10K4_08990	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K10K4_09030	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K10K4_09040	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K10K4_09050	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K10K4_09060	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K10K4_09100	COG0544	peptidyl-prolyl cis-trans isomerase activity
K10K4_09120	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K10K4_09130	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K10K4_09140	COG0776	regulation of translation
K10K4_09150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K10K4_09160	COG1555	photosystem II stabilization
K10K4_09190	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K10K4_09200	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K10K4_09210	COG0436	Aminotransferase
K10K4_09220	COG1169	isochorismate synthase
K10K4_09230	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K10K4_09250	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K10K4_09260	COG1441	menaquinone biosynthetic process
K10K4_09290	COG2855	membrane
K10K4_09300	COG0477	Major facilitator Superfamily
K10K4_09390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K10K4_09400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K10K4_09430	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K10K4_09440	COG1522	sequence-specific DNA binding
K10K4_09460	COG1946	Acyl-CoA thioesterase
K10K4_09470	COG3126	Type III secretion system lipoprotein chaperone (YscW)
K10K4_09500	COG3706	GGDEF domain
K10K4_09510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K10K4_09520	COG0516	GMP reductase activity
K10K4_09520	COG0517	IMP dehydrogenase activity
K10K4_09570	COG0537	adenosine 5'-monophosphoramidase activity
K10K4_09620	COG3150	esterase
K10K4_09630	COG1252	NADH dehydrogenase
K10K4_09660	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K10K4_09680	COG4591	ABC-type transport system involved in lipoprotein release permease component
K10K4_09690	COG1136	(ABC) transporter
K10K4_09700	COG4591	ABC-type transport system involved in lipoprotein release permease component
K10K4_09720	COG0658	competence protein
K10K4_09720	COG2333	competence protein COMEC
K10K4_09730	COG1132	(ABC) transporter
K10K4_09770	COG2719	SpoVR family
K10K4_09780	COG2718	Belongs to the UPF0229 family
K10K4_09790	COG2766	serine protein kinase
K10K4_09800	COG3013	Belongs to the UPF0304 family
K10K4_09820	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K10K4_09840	COG1882	Formate acetyltransferase
K10K4_09890	COG4215	(ABC) transporter
K10K4_09920	COG0708	Exodeoxyribonuclease III
K10K4_09940	COG3923	Primosomal replication protein n
K10K4_09950	COG0730	response to heat
K10K4_09960	COG1199	ATP-dependent helicase activity
K10K4_09980	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K10K4_09990	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K10K4_10000	COG1187	pseudouridine synthase activity
K10K4_10020	COG1278	Cold shock
K10K4_10030	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K10K4_10040	COG0542	response to heat
K10K4_10050	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K10K4_10060	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K10K4_10070	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K10K4_10110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K10K4_10120	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K10K4_10130	COG0297	glycogen (starch) synthase activity
K10K4_10170	COG3070	regulator of competence-specific genes
K10K4_10180	COG1609	Transcriptional regulator
K10K4_10190	COG3381	protein complex oligomerization
K10K4_10200	COG0745	RESPONSE REGULATOR receiver
K10K4_10210	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K10K4_10220	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K10K4_10230	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
K10K4_10240	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
K10K4_10250	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K10K4_10290	COG0189	ligase activity
K10K4_10290	COG4067	protein conserved in archaea
K10K4_10300	COG0500	methyltransferase
K10K4_10320	COG1801	Protein of unknown function DUF72
K10K4_10340	COG0217	transcriptional regulatory protein
K10K4_10350	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K10K4_10360	COG0632	four-way junction helicase activity
K10K4_10370	COG2255	four-way junction helicase activity
K10K4_10380	COG1271	oxidase subunit
K10K4_10390	COG1294	oxidase, subunit
K10K4_10400	COG4890	Cyd operon protein YbgT
K10K4_10420	COG0824	Thioesterase
K10K4_10430	COG0811	peptide transport
K10K4_10460	COG0823	Involved in the tonB-independent uptake of proteins
K10K4_10470	COG2885	chlorophyll binding
K10K4_10480	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
K10K4_10490	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K10K4_10510	COG3766	membrane
K10K4_10530	COG0754	glutathionylspermidine amidase activity
K10K4_10550	COG0784	Response regulator, receiver
K10K4_10550	COG5002	protein histidine kinase activity
K10K4_10590	COG1294	oxidase, subunit
K10K4_10600	COG1271	oxidase subunit
K10K4_10650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K10K4_10660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K10K4_10710	COG3568	Endonuclease Exonuclease Phosphatase
K10K4_10760	COG0583	DNA-binding transcription factor activity
K10K4_10780	COG0686	Belongs to the AlaDH PNT family
K10K4_10800	COG1674	ftsk spoiiie
K10K4_10820	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K10K4_10860	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K10K4_10870	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K10K4_10910	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K10K4_10950	COG0300	oxidoreductase activity
K10K4_10980	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K10K4_11000	COG2268	Band 7 protein
K10K4_11020	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K10K4_11030	COG2915	High frequency lysogenization protein hflD homolog
K10K4_11060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K10K4_11080	COG1757	Na H antiporter
K10K4_11100	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K10K4_11120	COG0131	Imidazoleglycerol-phosphate dehydratase
K10K4_11120	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K10K4_11130	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K10K4_11140	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K10K4_11150	COG0107	imidazoleglycerol-phosphate synthase activity
K10K4_11160	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K10K4_11160	COG0140	phosphoribosyl-ATP diphosphatase activity
K10K4_11170	COG3012	SEC-C Motif Domain Protein
K10K4_11180	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K10K4_11190	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K10K4_11200	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K10K4_11210	COG0215	cysteine-tRNA ligase activity
K10K4_11220	COG1435	thymidine kinase activity
K10K4_11280	COG2116	formate transmembrane transporter activity
K10K4_11300	COG0390	transport system, permease component
K10K4_11310	COG4459	periplasmic nitrate reductase
K10K4_11320	COG3005	denitrification pathway
K10K4_11330	COG0243	molybdopterin cofactor binding
K10K4_11360	COG1227	inorganic diphosphatase activity
K10K4_11380	COG4172	Belongs to the ABC transporter superfamily
K10K4_11400	COG4171	peptide transport system, permease
K10K4_11410	COG4168	peptide transport system, permease
K10K4_11430	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K10K4_11440	COG1842	Phage shock protein A
K10K4_11460	COG1983	PspC domain protein
K10K4_11500	COG2818	Glycosylase
K10K4_11510	COG5380	lipid catabolic process
K10K4_11520	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
K10K4_11530	COG0626	cystathionine gamma-synthase activity
K10K4_11550	COG0733	neurotransmitter:sodium symporter activity
K10K4_11560	COG0564	pseudouridine synthase activity
K10K4_11580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K10K4_11590	COG1151	hydroxylamine reductase activity
K10K4_11600	COG3604	Transcriptional regulator
K10K4_11620	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K10K4_11630	COG4136	ATPase activity
K10K4_11640	COG4135	transport system, permease component
K10K4_11650	COG4134	Bacterial extracellular solute-binding protein
K10K4_11700	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K10K4_11710	COG2205	protein histidine kinase activity
K10K4_11720	COG0745	RESPONSE REGULATOR receiver
K10K4_11740	COG1061	Type III restriction enzyme res subunit
K10K4_11750	COG1187	pseudouridine synthase activity
K10K4_11760	COG2814	Major facilitator Superfamily
K10K4_11780	COG0702	epimerase
K10K4_11790	COG0534	Mate efflux family protein
K10K4_11830	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K10K4_11850	COG1960	acyl-CoA dehydrogenase activity
K10K4_11860	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K10K4_11870	COG3273	potassium ion transport
K10K4_11870	COG2985	domain, Protein
K10K4_11880	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K10K4_11910	COG1737	Transcriptional regulator
K10K4_11920	COG0076	glutamate decarboxylase activity
K10K4_11940	COG2431	L-lysine efflux transmembrane transporter activity
K10K4_11960	COG3070	regulator of competence-specific genes
K10K4_12000	COG4191	Histidine kinase
K10K4_12000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K10K4_12020	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K10K4_12040	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K10K4_12050	COG4988	ABC transporter
K10K4_12060	COG0492	ferredoxin-NADP+ reductase activity
K10K4_12100	COG0745	RESPONSE REGULATOR receiver
K10K4_12100	COG3706	GGDEF domain
K10K4_12110	COG0471	metal ion transport
K10K4_12120	COG2949	membrane
K10K4_12130	COG0281	malic enzyme
K10K4_12140	COG1643	Atp-dependent helicase
K10K4_12170	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K10K4_12240	COG0277	FAD linked oxidase domain protein
K10K4_12240	COG0247	lactate metabolic process
K10K4_12270	COG2986	histidine ammonia-lyase
K10K4_12280	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K10K4_12290	COG0010	Belongs to the arginase family
K10K4_12300	COG1228	amidohydrolase
K10K4_12340	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K10K4_12360	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K10K4_12380	COG0393	Putative heavy-metal-binding
K10K4_12450	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K10K4_12460	COG0072	phenylalanine-tRNA ligase activity
K10K4_12460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K10K4_12480	COG0776	regulation of translation
K10K4_12500	COG0500	methyltransferase
K10K4_12510	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K10K4_12520	COG0295	cytidine deaminase activity
K10K4_12530	COG1346	cytolysis
K10K4_12540	COG1380	Effector of murein hydrolase LrgA
K10K4_12550	COG2925	Exonuclease
K10K4_12670	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K10K4_12730	COG1484	DNA-dependent DNA replication
K10K4_13030	COG0702	epimerase
K10K4_13040	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K10K4_13050	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K10K4_13090	COG2988	succinylglutamate desuccinylase activity
K10K4_13100	COG4139	cobalamin transport
K10K4_13110	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
K10K4_13150	COG0583	DNA-binding transcription factor activity
K10K4_13170	COG1451	nucleotide metabolic process
K10K4_13180	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
K10K4_13240	COG3938	Belongs to the proline racemase family
K10K4_13270	COG2423	ornithine cyclodeaminase activity
K10K4_13280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K10K4_13290	COG3842	ATPase activity
K10K4_13300	COG1176	ABC-type spermidine putrescine transport system, permease component I
K10K4_13310	COG1177	transmembrane transport
K10K4_13330	COG3291	Pkd domain containing protein
K10K4_13360	COG0444	Belongs to the ABC transporter superfamily
K10K4_13370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K10K4_13380	COG0601	transmembrane transport
K10K4_13400	COG2195	Cleaves the N-terminal amino acid of tripeptides
K10K4_13420	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K10K4_13440	COG0625	glutathione transferase activity
K10K4_13540	COG3755	Protein conserved in bacteria
K10K4_13590	COG1742	UPF0060 membrane protein
K10K4_13620	COG1757	Na H antiporter
K10K4_13630	COG0174	glutamine synthetase
K10K4_13640	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K10K4_13650	COG1396	sequence-specific DNA binding
K10K4_13650	COG1917	Cupin 2, conserved barrel domain protein
K10K4_13660	COG1012	belongs to the aldehyde dehydrogenase family
K10K4_13670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K10K4_13690	COG2957	Belongs to the agmatine deiminase family
K10K4_13700	COG1012	belongs to the aldehyde dehydrogenase family
K10K4_13710	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K10K4_13720	COG2200	EAL domain
K10K4_13740	COG1846	Transcriptional regulator
K10K4_13750	COG2315	Protein conserved in bacteria
K10K4_13830	COG3063	Type IV pilus biogenesis stability protein PilW
K10K4_13840	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K10K4_13870	COG1560	Kdo2-lipid A biosynthetic process
K10K4_13890	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K10K4_14130	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K10K4_14140	COG1280	lysine exporter protein (LysE YggA)
K10K4_14160	COG1115	amino acid carrier protein
K10K4_14210	COG1368	sulfuric ester hydrolase activity
K10K4_14220	COG2113	Glycine betaine
K10K4_14230	COG4176	ABC-type proline glycine betaine transport system permease component
K10K4_14240	COG4175	Glycine betaine
K10K4_14270	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K10K4_14280	COG0456	acetyltransferase
K10K4_14290	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K10K4_14300	COG0662	Cupin 2, conserved barrel domain protein
K10K4_14310	COG0527	aspartate kinase activity
K10K4_14320	COG3119	arylsulfatase activity
K10K4_14350	COG0641	radical SAM
K10K4_14380	COG3119	arylsulfatase activity
K10K4_14430	COG1538	Outer membrane efflux protein
K10K4_14460	COG1349	DNA-binding transcription factor activity
K10K4_14470	COG0673	inositol 2-dehydrogenase activity
K10K4_14480	COG4702	Belongs to the UPF0303 family
K10K4_14490	COG0745	RESPONSE REGULATOR receiver
K10K4_14490	COG3706	GGDEF domain
K10K4_14530	COG0471	metal ion transport
K10K4_14560	COG5001	Diguanylate cyclase
K10K4_14560	COG3300	MHYT domain
K10K4_14590	COG1328	CTP reductase activity
K10K4_14600	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K10K4_14620	COG0861	Integral membrane protein TerC family
K10K4_14640	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K10K4_14660	COG0814	amino acid
K10K4_14690	COG1120	ATPase activity
K10K4_14700	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K10K4_14720	COG4774	siderophore transport
K10K4_14740	COG1132	(ABC) transporter
K10K4_14750	COG1132	(ABC) transporter
K10K4_14780	COG0583	DNA-binding transcription factor activity
K10K4_14830	COG0443	Heat shock 70 kDa protein
K10K4_14840	COG0443	Heat shock 70 kDa protein
K10K4_14940	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K10K4_14950	COG1643	Atp-dependent helicase
K10K4_14980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K10K4_15000	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K10K4_15010	COG1215	transferase activity, transferring glycosyl groups
K10K4_15020	COG0438	transferase activity, transferring glycosyl groups
K10K4_15080	COG0438	transferase activity, transferring glycosyl groups
K10K4_15090	COG0438	transferase activity, transferring glycosyl groups
K10K4_15100	COG2204	response regulator
K10K4_15170	COG1793	dna ligase
K10K4_15190	COG0534	Mate efflux family protein
K10K4_15200	COG0307	riboflavin synthase, alpha
K10K4_15240	COG3706	GGDEF domain
K10K4_15260	COG0791	NLP P60 protein
K10K4_15340	COG1940	carbohydrate kinase activity
K10K4_15370	COG0746	molybdenum cofactor guanylyltransferase activity
K10K4_15380	COG3842	ATPase activity
K10K4_15410	COG2204	response regulator
K10K4_15420	COG4191	Histidine kinase
K10K4_15430	COG0488	(ABC) transporter
K10K4_15450	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K10K4_15490	COG3381	protein complex oligomerization
K10K4_15510	COG0243	molybdopterin cofactor binding
K10K4_15510	COG3383	formate dehydrogenase (NAD+) activity
K10K4_15520	COG0437	4 iron, 4 sulfur cluster binding
K10K4_15570	COG0004	ammonium transporteR
K10K4_15590	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K10K4_15600	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K10K4_15610	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K10K4_15620	COG1177	transmembrane transport
K10K4_15630	COG1176	ABC-type spermidine putrescine transport system, permease component I
K10K4_15640	COG3842	ATPase activity
K10K4_15690	COG0589	response to stress
K10K4_15700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K10K4_15730	COG2217	Heavy metal translocating P-type atpase
K10K4_15750	COG2010	Cytochrome c
K10K4_15780	COG3278	Belongs to the heme-copper respiratory oxidase family
K10K4_15810	COG2205	protein histidine kinase activity
K10K4_15810	COG0784	Response regulator, receiver
K10K4_15910	COG4128	Pfam Zonular occludens toxin
K10K4_15960	COG3120	sequence-specific DNA binding
K10K4_15970	COG1067	ATP-dependent peptidase activity
K10K4_15980	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K10K4_16030	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K10K4_16030	COG0116	Belongs to the methyltransferase superfamily
K10K4_16050	COG0167	dihydroorotate dehydrogenase activity
K10K4_16060	COG2902	Dehydrogenase
K10K4_16070	COG0308	aminopeptidase N
K10K4_16100	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
K10K4_16110	COG1956	GAF domain-containing protein
K10K4_16120	COG1132	(ABC) transporter
K10K4_16130	COG2995	paraquat-inducible protein a
K10K4_16140	COG3008	intermembrane lipid transfer
K10K4_16190	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K10K4_16200	COG1666	GTP binding
K10K4_16220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K10K4_16240	COG4597	amino acid ABC transporter
K10K4_16250	COG0765	amino acid transport
K10K4_16260	COG1126	abc transporter atp-binding protein
K10K4_16270	COG0670	Belongs to the BI1 family
K10K4_16290	COG2920	part of a sulfur-relay system
K10K4_16300	COG1254	Belongs to the acylphosphatase family
K10K4_16310	COG0840	transmembrane signaling receptor activity
K10K4_16350	COG2885	chlorophyll binding
K10K4_16400	COG2203	Gaf domain
K10K4_16400	COG2199	diguanylate cyclase activity
K10K4_16410	COG1414	Transcriptional regulator
K10K4_16430	COG0656	L-ascorbic acid biosynthetic process
K10K4_16440	COG0583	DNA-binding transcription factor activity
K10K4_16460	COG0583	DNA-binding transcription factor activity
K10K4_16470	COG2814	Major facilitator Superfamily
K10K4_16510	COG1335	isochorismatase
K10K4_16520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K10K4_16550	COG1410	methionine synthase
K10K4_16550	COG0646	methionine synthase
K10K4_16560	COG1126	abc transporter atp-binding protein
K10K4_16570	COG0765	amino acid transport
K10K4_16580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K10K4_16620	COG0583	DNA-binding transcription factor activity
K10K4_16650	COG0583	DNA-binding transcription factor activity
K10K4_16670	COG0583	DNA-binding transcription factor activity
K10K4_16700	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K10K4_16710	COG0602	queuosine metabolic process
K10K4_16720	COG0561	phosphatase activity
K10K4_16770	COG2828	Protein conserved in bacteria
K10K4_16790	COG0372	Belongs to the citrate synthase family
K10K4_16800	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K10K4_16870	COG0730	response to heat
K10K4_16910	COG0457	Tetratricopeptide repeat
K10K4_17040	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K10K4_17050	COG4790	Type iii secretion
K10K4_17060	COG4794	Type iii secretion
K10K4_17070	COG4791	protein targeting
K10K4_17080	COG4792	protein secretion
K10K4_17090	COG2207	Transcriptional regulator
K10K4_17150	COG3177	Filamentation induced by cAMP protein fic
K10K4_17190	COG4669	(LipO)protein
K10K4_17330	COG1012	belongs to the aldehyde dehydrogenase family
K10K4_17340	COG3284	Transcriptional regulator
K10K4_17370	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K10K4_17380	COG0363	glucosamine-6-phosphate deaminase activity
K10K4_17390	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K10K4_17400	COG2207	Transcriptional regulator
K10K4_17420	COG4565	transcriptional regulatory protein
K10K4_17430	COG3290	protein histidine kinase activity
K10K4_17460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K10K4_17520	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K10K4_17540	COG2985	domain, Protein
K10K4_17610	COG2272	Belongs to the type-B carboxylesterase lipase family
K10K4_17640	COG0729	surface antigen
K10K4_17660	COG1280	lysine exporter protein (LysE YggA)
K10K4_17670	COG1280	lysine exporter protein (LysE YggA)
K10K4_17680	COG5507	3-demethylubiquinone-9 3-methyltransferase
K10K4_17720	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K10K4_17740	COG0110	maltose O-acetyltransferase activity
K10K4_17820	COG2801	Transposase and inactivated derivatives
K10K4_17870	COG1683	Conserved Protein
K10K4_17990	COG2801	Transposase and inactivated derivatives
K10K4_18040	COG1403	HNH endonuclease
K10K4_18170	COG4974	Belongs to the 'phage' integrase family
K10K4_18200	COG3706	GGDEF domain
K10K4_18220	COG2985	domain, Protein
K10K4_18230	COG0076	glutamate decarboxylase activity
K10K4_18240	COG0598	Magnesium transport protein CorA
K10K4_18260	COG0387	Pfam Sodium calcium exchanger
K10K4_18270	COG0387	Pfam Sodium calcium exchanger
K10K4_18300	COG1289	transmembrane transporter activity
K10K4_18330	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K10K4_18350	COG2985	domain, Protein
K10K4_18360	COG0025	NhaP-type Na H and K H
K10K4_18380	COG2433	Pfam Transposase IS66
K10K4_18400	COG3302	dmso reductase anchor subunit
K10K4_18410	COG0437	4 iron, 4 sulfur cluster binding
K10K4_18420	COG0243	molybdopterin cofactor binding
K10K4_18440	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K10K4_18440	COG2221	Nitrite and sulphite reductase 4Fe-4S
K10K4_18450	COG0784	Response regulator, receiver
K10K4_18450	COG2205	protein histidine kinase activity
K10K4_18540	COG2204	response regulator
K10K4_18590	COG3477	response to acidic pH
K10K4_18600	COG3287	FIST C domain
K10K4_18600	COG2200	EAL domain
K10K4_18600	COG2199	diguanylate cyclase activity
K10K4_18610	COG2197	response regulator
K10K4_18750	COG1472	Belongs to the glycosyl hydrolase 3 family
K10K4_18770	COG2205	protein histidine kinase activity
K10K4_18770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K10K4_18780	COG2197	response regulator
K10K4_18900	COG1335	isochorismatase
K10K4_19030	COG4628	conserved protein (DUF2132)
K10K4_19090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K10K4_19110	COG3768	UPF0283 membrane protein
K10K4_19120	COG3106	COG3106 Predicted ATPase
K10K4_19150	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K10K4_19160	COG2205	protein histidine kinase activity
K10K4_19160	COG0784	Response regulator, receiver
K10K4_19180	COG0494	nUDIX hydrolase
K10K4_19190	COG0814	amino acid
K10K4_19200	COG1760	l-serine dehydratase
K10K4_19210	COG2200	EAL domain
K10K4_19230	COG0720	synthase
K10K4_19240	COG0840	transmembrane signaling receptor activity
K10K4_19250	COG0017	Asparaginyl-tRNA synthetase
K10K4_19270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K10K4_19300	COG1448	Aminotransferase
K10K4_19340	COG0840	transmembrane signaling receptor activity
K10K4_19350	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K10K4_19410	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K10K4_19440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K10K4_19450	COG3108	Peptidase M15
K10K4_19460	COG2989	Protein conserved in bacteria
K10K4_19510	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K10K4_19530	COG3088	subunit of a heme lyase
K10K4_19530	COG4235	cytochrome complex assembly
K10K4_19550	COG1138	Cytochrome C-type biogenesis protein
K10K4_19560	COG3301	Polysulphide reductase, NrfD
K10K4_19570	COG0437	4 iron, 4 sulfur cluster binding
K10K4_19590	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
K10K4_19630	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K10K4_19640	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K10K4_19650	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K10K4_19700	COG0019	diaminopimelate decarboxylase activity
K10K4_19780	COG0322	excinuclease ABC activity
K10K4_19790	COG2197	response regulator
K10K4_19800	COG0417	DNA replication proofreading
K10K4_19840	COG1187	pseudouridine synthase activity
K10K4_19860	COG0009	L-threonylcarbamoyladenylate synthase
K10K4_19870	COG0613	PHP domain protein
K10K4_19890	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K10K4_19900	COG0512	Glutamine amidotransferase of anthranilate synthase
K10K4_19920	COG0135	phosphoribosylanthranilate isomerase activity
K10K4_19920	COG0134	indole-3-glycerol-phosphate synthase activity
K10K4_19940	COG0159	tryptophan synthase activity
K10K4_19950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K10K4_19960	COG0318	PFAM AMP-dependent synthetase and ligase
K10K4_19970	COG1301	dicarboxylic acid transport
K10K4_20010	COG2917	probably involved in intracellular septation
K10K4_20020	COG1607	acyl-coa hydrolase
K10K4_20030	COG2350	Protein conserved in bacteria
K10K4_20050	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K10K4_20060	COG0583	DNA-binding transcription factor activity
K10K4_20090	COG5001	Diguanylate cyclase
K10K4_20100	COG1032	radical SAM domain protein
K10K4_20140	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K10K4_20150	COG0463	Glycosyl transferase, family 2
K10K4_20160	COG0745	RESPONSE REGULATOR receiver
K10K4_20170	COG5002	protein histidine kinase activity
K10K4_20170	COG3850	Histidine kinase
K10K4_20230	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K10K4_20270	COG0577	efflux transmembrane transporter activity
K10K4_20270	COG1136	(ABC) transporter
K10K4_20280	COG1136	(ABC) transporter
K10K4_20280	COG0577	efflux transmembrane transporter activity
K10K4_20290	COG1136	(ABC) transporter
K10K4_20290	COG0577	efflux transmembrane transporter activity
K10K4_20310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K10K4_20360	COG3118	belongs to the thioredoxin family
K10K4_20370	COG4232	protein-disulfide reductase activity
K10K4_20440	COG2863	cytochrome
K10K4_20450	COG3258	Cytochrome c
K10K4_20460	COG2995	paraquat-inducible protein a
K10K4_20470	COG3008	intermembrane lipid transfer
K10K4_20470	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K10K4_20510	COG4166	transmembrane transport
K10K4_20530	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K10K4_20540	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
K10K4_20560	COG0539	negative regulation of cytoplasmic translation
K10K4_20570	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K10K4_20580	COG0616	signal peptide processing
K10K4_20590	COG1028	Short-chain dehydrogenase reductase Sdr
K10K4_20620	COG0587	DNA-directed DNA polymerase activity
K10K4_20630	COG0784	Response regulator, receiver
K10K4_20630	COG0835	chemotaxis
K10K4_20640	COG1940	carbohydrate kinase activity
K10K4_20650	COG0469	pyruvate kinase activity
K10K4_20660	COG4667	esterase of the alpha-beta hydrolase superfamily
K10K4_20690	COG0733	neurotransmitter:sodium symporter activity
K10K4_20720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K10K4_20720	COG1263	PTS System
K10K4_20730	COG0084	hydrolase, TatD family'
K10K4_20740	COG0470	DNA polymerase III
K10K4_20750	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K10K4_20760	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K10K4_20820	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K10K4_20830	COG0416	fatty acid biosynthetic process
K10K4_20850	COG1399	metal-binding, possibly nucleic acid-binding protein
K10K4_20860	COG0424	maF-like protein
K10K4_20870	COG0564	pseudouridine synthase activity
K10K4_20880	COG1530	ribonuclease E activity
K10K4_20890	COG0659	secondary active sulfate transmembrane transporter activity
K10K4_20900	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K10K4_20910	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
K10K4_20930	COG0572	uridine kinase
K10K4_20950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K10K4_20950	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K10K4_20990	COG2186	Transcriptional regulator
K10K4_21000	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K10K4_21010	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K10K4_21020	COG3318	Belongs to the UPF0149 family
K10K4_21020	COG3012	SEC-C Motif Domain Protein
K10K4_21030	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K10K4_21040	COG3706	GGDEF domain
K10K4_21050	COG0366	Alpha amylase catalytic
K10K4_21060	COG1122	ATPase activity
K10K4_21070	COG4120	Belongs to the binding-protein-dependent transport system permease family
K10K4_21090	COG3092	negative regulation of chromosome organization
K10K4_21100	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K10K4_21110	COG0857	belongs to the CobB CobQ family
K10K4_21110	COG0280	phosphate acetyltransferase
K10K4_21130	COG0435	Glutathione S-transferase
K10K4_21150	COG0444	Belongs to the ABC transporter superfamily
K10K4_21160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K10K4_21170	COG0601	transmembrane transport
K10K4_21190	COG0314	molybdopterin synthase activity
K10K4_21200	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K10K4_21210	COG0315	cyclic pyranopterin monophosphate synthase activity
K10K4_21220	COG0521	Mo-molybdopterin cofactor biosynthetic process
K10K4_21230	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K10K4_21240	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K10K4_21250	COG2198	Histidine kinase
K10K4_21260	COG2204	response regulator
K10K4_21270	COG0556	nucleotide-excision repair
K10K4_21290	COG1882	Formate acetyltransferase
K10K4_21300	COG4657	Part of a membrane complex involved in electron transport
K10K4_21310	COG2878	Part of a membrane complex involved in electron transport
K10K4_21320	COG4656	Part of a membrane complex involved in electron transport
K10K4_21330	COG4658	electron transport chain
K10K4_21340	COG4659	FMN binding
K10K4_21350	COG4660	Part of a membrane complex involved in electron transport
K10K4_21360	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K10K4_21370	COG0346	lactoylglutathione lyase activity
K10K4_21390	COG2885	chlorophyll binding
K10K4_21400	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K10K4_21410	COG2056	Na+-H+ antiporter family
K10K4_21450	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K10K4_21490	COG1454	alcohol dehydrogenase
K10K4_21490	COG1012	belongs to the aldehyde dehydrogenase family
K10K4_21500	COG2095	MarC family integral membrane protein
K10K4_21510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K10K4_21520	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K10K4_21530	COG1757	Na H antiporter
K10K4_21560	COG3081	Nucleoid-associated protein
K10K4_21570	COG3082	Protein of unknown function (DUF1414)
K10K4_21580	COG3083	sulfuric ester hydrolase activity
K10K4_21600	COG0123	including yeast histone deacetylase and acetoin utilization protein
K10K4_21640	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K10K4_21650	COG0778	Nitroreductase
K10K4_21670	COG1902	pentaerythritol trinitrate reductase activity
K10K4_21670	COG0446	pyridine nucleotide-disulphide oxidoreductase
K10K4_21680	COG0616	signal peptide processing
K10K4_21690	COG0252	asparaginase activity
K10K4_21700	COG3139	Protein of unknown function (DUF1315)
K10K4_21720	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K10K4_21730	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K10K4_21760	COG2226	methyltransferase
K10K4_21790	COG1785	Belongs to the alkaline phosphatase family
K10K4_21810	COG0346	lactoylglutathione lyase activity
K10K4_21820	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
K10K4_21830	COG0668	transmembrane transport
K10K4_21840	COG2983	Belongs to the UPF0260 family
K10K4_21850	COG2261	transglycosylase associated protein
K10K4_21870	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K10K4_21880	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K10K4_21890	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K10K4_21910	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K10K4_21920	COG2832	Protein of unknown function (DUF454)
K10K4_21940	COG0745	RESPONSE REGULATOR receiver
K10K4_21950	COG0583	DNA-binding transcription factor activity
K10K4_21960	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K10K4_21970	COG1286	toxin biosynthetic process
K10K4_21980	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
K10K4_21990	COG0285	dihydrofolate synthase activity
K10K4_22000	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K10K4_22010	COG0101	tRNA pseudouridine synthase activity
K10K4_22030	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K10K4_22040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K10K4_22050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K10K4_22060	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K10K4_22060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K10K4_22070	COG0431	NADPH-dependent FMN reductase
K10K4_22090	COG3101	peptidyl-lysine hydroxylation
K10K4_22100	COG2860	membrane
K10K4_22110	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K10K4_22120	COG2890	protein-(glutamine-N5) methyltransferase activity
K10K4_22130	COG2840	Smr protein MutS2
K10K4_22140	COG2062	phosphohistidine phosphatase, SixA
K10K4_22170	COG1024	Enoyl-CoA hydratase
K10K4_22170	COG1250	3-hydroxyacyl-CoA dehydrogenase
K10K4_22180	COG0183	Belongs to the thiolase family
K10K4_22230	COG2067	long-chain fatty acid transport protein
K10K4_22250	COG3088	subunit of a heme lyase
K10K4_22250	COG4235	cytochrome complex assembly
K10K4_22270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K10K4_22280	COG1138	Cytochrome C-type biogenesis protein
K10K4_22290	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K10K4_22300	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K10K4_22310	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K10K4_22320	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K10K4_22330	COG4133	protoheme IX ABC transporter activity
K10K4_22350	COG0835	chemotaxis
K10K4_22370	COG1192	Involved in chromosome partitioning
K10K4_22380	COG2201	protein-glutamate methylesterase activity
K10K4_22390	COG2198	Histidine kinase
K10K4_22390	COG0643	Histidine kinase
K10K4_22400	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
K10K4_22430	COG0455	bacterial-type flagellum organization
K10K4_22470	COG1684	flagellar biosynthetic protein fliR
K10K4_22480	COG1987	bacterial-type flagellum assembly
K10K4_22590	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K10K4_22610	COG1677	Flagellar hook-basal body complex protein FliE
K10K4_22620	COG2204	response regulator
K10K4_22630	COG4191	Histidine kinase
K10K4_22640	COG2204	response regulator
K10K4_22650	COG1516	flagellar protein fliS
K10K4_22670	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K10K4_22680	COG1334	flagellar protein FlaG
K10K4_22690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K10K4_22700	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K10K4_22710	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K10K4_22720	COG2837	iron assimilation
K10K4_22770	COG1393	Belongs to the ArsC family
K10K4_22780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K10K4_22820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K10K4_22840	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K10K4_22890	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K10K4_22910	COG1053	succinate dehydrogenase
K10K4_23040	COG0210	DNA helicase
K10K4_23080	COG2963	transposase activity
K10K4_23110	COG1278	Cold shock
K10K4_23160	COG1278	Cold shock
K10K4_23170	COG4974	Belongs to the 'phage' integrase family
K10K4_23180	COG0330	HflC and HflK could
K10K4_23220	COG1278	Cold shock
K10K4_23250	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K10K4_23280	COG4783	chaperone-mediated protein folding
K10K4_23290	COG1393	Belongs to the ArsC family
K10K4_23330	COG2233	PERMEase
K10K4_23340	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K10K4_23350	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K10K4_23360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K10K4_23380	COG0121	glutamine amidotransferase
K10K4_23390	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K10K4_23400	COG1960	acyl-CoA dehydrogenase activity
K10K4_23460	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K10K4_23470	COG0328	RNA-DNA hybrid ribonuclease activity
K10K4_23480	COG2226	methyltransferase
K10K4_23490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K10K4_23500	COG0741	lytic transglycosylase activity
K10K4_23500	COG1388	LysM domain
K10K4_23520	COG3021	interspecies interaction between organisms
K10K4_23530	COG0347	Belongs to the P(II) protein family
K10K4_23560	COG0825	malonyl-CoA metabolic process
K10K4_23570	COG0587	DNA-directed DNA polymerase activity
K10K4_23590	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K10K4_23600	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K10K4_23620	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K10K4_23630	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
K10K4_23650	COG0750	zinc metalloprotease
K10K4_23660	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K10K4_23670	COG0575	Belongs to the CDS family
K10K4_23680	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K10K4_23690	COG0233	cytoplasmic translational termination
K10K4_23700	COG0528	UMP kinase activity
K10K4_23710	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K10K4_23720	COG0052	Belongs to the universal ribosomal protein uS2 family
K10K4_23730	COG0024	Methionine aminopeptidase
K10K4_23740	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K10K4_23760	COG0564	pseudouridine synthase activity
K10K4_23770	COG3098	single-species biofilm formation
K10K4_23830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K10K4_23840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K10K4_23890	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K10K4_23900	COG0254	rRNA binding
K10K4_23910	COG1720	tRNA m6t6A37 methyltransferase activity
K10K4_23920	COG0442	prolyl-tRNA aminoacylation
K10K4_23960	COG0733	neurotransmitter:sodium symporter activity
K10K4_23990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K10K4_24000	COG0514	ATP-dependent DNA helicase (RecQ)
K10K4_24050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K10K4_24210	COG0659	secondary active sulfate transmembrane transporter activity
K10K4_24220	COG0589	response to stress
K10K4_24230	COG0519	Catalyzes the synthesis of GMP from XMP
K10K4_24330	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K10K4_24350	COG3706	GGDEF domain
K10K4_24350	COG0745	RESPONSE REGULATOR receiver
K10K4_24370	COG1477	protein flavinylation
K10K4_24380	COG2871	sodium ion transport
K10K4_24390	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K10K4_24400	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K10K4_24410	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K10K4_24420	COG1805	sodium ion transport
K10K4_24430	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K10K4_24440	COG0271	Belongs to the BolA IbaG family
K10K4_24450	COG2813	Specifically methylates the guanine in position
K10K4_24460	COG3056	Lipoprotein
K10K4_24500	COG1595	DNA-templated transcription, initiation
K10K4_24540	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K10K4_24550	COG0693	protein deglycase activity
K10K4_24560	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K10K4_24570	COG3706	GGDEF domain
K10K4_24580	COG2166	iron-sulfur cluster assembly
K10K4_24590	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K10K4_24600	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
K10K4_24620	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K10K4_24620	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K10K4_24640	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K10K4_24650	COG1074	ATP-dependent DNA helicase activity
K10K4_24660	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K10K4_24760	COG0270	DNA (cytosine-5-)-methyltransferase activity
K10K4_24810	COG3141	response to X-ray
K10K4_24840	COG2171	N-acyltransferase activity
K10K4_24850	COG0584	glycerophosphoryl diester phosphodiesterase
K10K4_24860	COG2271	Major facilitator Superfamily
K10K4_24870	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K10K4_24880	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K10K4_24890	COG1349	DNA-binding transcription factor activity
K10K4_24900	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K10K4_24910	COG0598	Magnesium transport protein CorA
K10K4_24950	COG1609	Transcriptional regulator
K10K4_24960	COG0583	DNA-binding transcription factor activity
K10K4_25040	COG1022	Amp-dependent synthetase and ligase
K10K4_25060	COG0583	DNA-binding transcription factor activity
K10K4_25070	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K10K4_25080	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K10K4_25100	COG0560	Phosphoserine phosphatase
K10K4_25120	COG0813	purine-nucleoside phosphorylase activity
K10K4_25130	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K10K4_25140	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K10K4_25150	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K10K4_25160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K10K4_25170	COG0084	hydrolase, TatD family'
K10K4_25230	COG3153	acetyltransferase
K10K4_25280	COG0534	Mate efflux family protein
K10K4_25310	COG1185	polyribonucleotide nucleotidyltransferase activity
K10K4_25320	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K10K4_25330	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K10K4_25340	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K10K4_25350	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K10K4_25360	COG0195	Participates in both transcription termination and antitermination
K10K4_25370	COG0779	Required for maturation of 30S ribosomal subunits
K10K4_25400	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K10K4_25410	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K10K4_25420	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K10K4_25430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K10K4_25440	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K10K4_25450	COG1534	Rna-binding protein
K10K4_25460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K10K4_25470	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K10K4_25480	COG2027	D-alanyl-D-alanine carboxypeptidase
K10K4_25500	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K10K4_25510	COG0739	heme binding
K10K4_25560	COG0628	permease
K10K4_25590	COG0747	negative chemotaxis
K10K4_25610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K10K4_25620	COG0444	Belongs to the ABC transporter superfamily
K10K4_25630	COG4608	Belongs to the ABC transporter superfamily
K10K4_25650	COG2971	BadF BadG BcrA BcrD
K10K4_25680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K10K4_25690	COG3842	ATPase activity
K10K4_25710	COG1840	ABC-type Fe3 transport system, periplasmic component
K10K4_25720	COG0004	ammonium transporteR
K10K4_25740	COG3112	Uncharacterised protein family (UPF0231)
K10K4_25750	COG1049	propionate catabolic process, 2-methylcitrate cycle
K10K4_25760	COG1752	Esterase of the alpha-beta hydrolase superfamily
K10K4_25770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K10K4_25780	COG1643	Atp-dependent helicase
K10K4_25790	COG1489	DNA binding
K10K4_25800	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K10K4_25810	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K10K4_25830	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K10K4_25840	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K10K4_25850	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K10K4_25860	COG1560	Kdo2-lipid A biosynthetic process
K10K4_25870	COG0842	Transport permease protein
K10K4_25880	COG1131	(ABC) transporter
K10K4_25890	COG0659	secondary active sulfate transmembrane transporter activity
K10K4_25900	COG0288	reversible hydration of carbon dioxide
K10K4_25930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K10K4_25940	COG0508	dehydrogenase complex catalyzes the overall conversion of
K10K4_25950	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K10K4_25960	COG2186	Transcriptional regulator
K10K4_25980	COG0157	Belongs to the NadC ModD family
K10K4_25990	COG4969	Belongs to the N-Me-Phe pilin family
K10K4_26000	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K10K4_26010	COG1459	type II secretion system
K10K4_26030	COG0237	dephospho-CoA kinase activity
K10K4_26040	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
K10K4_26050	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K10K4_26080	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K10K4_26090	COG0228	four-way junction DNA binding
K10K4_26100	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K10K4_26110	COG4137	Cytochrome C assembly protein
K10K4_26120	COG4536	flavin adenine dinucleotide binding
K10K4_26130	COG1854	S-ribosylhomocysteine lyase activity
K10K4_26160	COG0612	Peptidase, M16
K10K4_26170	COG1238	metal cluster binding
K10K4_26190	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K10K4_26200	COG0511	ligase activity, forming carbon-carbon bonds
K10K4_26200	COG5016	pyruvate
K10K4_26330	COG0527	aspartate kinase activity
K10K4_26340	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K10K4_26350	COG2137	regulation of response to DNA damage stimulus
K10K4_26360	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K10K4_26370	COG1546	Belongs to the CinA family
K10K4_26380	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K10K4_26390	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K10K4_26410	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K10K4_26420	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K10K4_26440	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K10K4_26450	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K10K4_26460	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K10K4_26470	COG0148	phosphopyruvate hydratase activity
K10K4_26480	COG0504	CTP synthase activity
K10K4_26490	COG3956	TIGRFAM MazG family protein
K10K4_26510	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K10K4_26520	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K10K4_26540	COG0736	holo-[acyl-carrier-protein] synthase activity
K10K4_26550	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K10K4_26560	COG1381	Involved in DNA repair and RecF pathway recombination
K10K4_26570	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K10K4_26590	COG0681	Belongs to the peptidase S26 family
K10K4_26600	COG0481	GTPase activity
K10K4_26610	COG3086	response to oxidative stress
K10K4_26640	COG1595	DNA-templated transcription, initiation
K10K4_26650	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K10K4_26670	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K10K4_26710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K10K4_26720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K10K4_26730	COG3079	Belongs to the UPF0149 family
K10K4_26740	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K10K4_26750	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K10K4_26760	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K10K4_26770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K10K4_26790	COG0583	DNA-binding transcription factor activity
K10K4_26820	COG0668	transmembrane transport
K10K4_26830	COG0191	fructose-bisphosphate aldolase activity
K10K4_26860	COG4771	TonB-dependent receptor
K10K4_26870	COG0583	DNA-binding transcription factor activity
K10K4_26880	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K10K4_26890	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K10K4_26910	COG3091	SprT-like family
K10K4_26920	COG2356	endonuclease I
K10K4_26930	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K10K4_26940	COG0189	ligase activity
K10K4_26950	COG1678	Uncharacterized ACR, COG1678
K10K4_26960	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K10K4_26990	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K10K4_27000	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K10K4_27010	COG0762	integral membrane protein
K10K4_27020	COG1872	DUF167
K10K4_27040	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K10K4_27050	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K10K4_27060	COG2066	Belongs to the glutaminase family
K10K4_27080	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K10K4_27100	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
K10K4_27190	COG0840	transmembrane signaling receptor activity
K10K4_27340	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K10K4_27360	COG3394	polysaccharide catabolic process
K10K4_27370	COG1486	melibiose metabolic process
K10K4_27380	COG1447	Phosphotransferase system cellobiose-specific component IIA
K10K4_27390	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K10K4_27410	COG0726	polysaccharide deacetylase
K10K4_27430	COG1028	Short-chain dehydrogenase reductase Sdr
K10K4_27440	COG4325	translation initiation factor activity
K10K4_27460	COG0795	lipopolysaccharide-transporting ATPase activity
K10K4_27470	COG0795	lipopolysaccharide-transporting ATPase activity
K10K4_27480	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K10K4_27490	COG2927	DNA polymerase III (CHI subunit)
K10K4_27500	COG0525	valine-tRNA ligase activity
K10K4_27520	COG0456	acetyltransferase
K10K4_27580	COG0540	Belongs to the ATCase OTCase family
K10K4_27590	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K10K4_27600	COG0251	oxidation-reduction process
K10K4_27610	COG0204	Acyl-transferase
K10K4_27620	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K10K4_27630	COG5007	Belongs to the BolA IbaG family
K10K4_27650	COG2854	intermembrane phospholipid transfer
K10K4_27660	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K10K4_27670	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K10K4_27680	COG1127	ABC transporter
K10K4_27700	COG0517	IMP dehydrogenase activity
K10K4_27700	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K10K4_27720	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K10K4_27730	COG1137	ATPase activity
K10K4_27750	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K10K4_27760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K10K4_27770	COG1660	Displays ATPase and GTPase activities
K10K4_27780	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K10K4_27790	COG2239	Acts as a magnesium transporter
K10K4_27800	COG0312	modulator of DNA gyrase
K10K4_27810	COG3028	Belongs to the UPF0307 family
K10K4_27820	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K10K4_27830	COG0564	pseudouridine synthase activity
K10K4_27850	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K10K4_27860	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K10K4_27870	COG0312	modulator of DNA gyrase
K10K4_27880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K10K4_27890	COG3164	Protein of unknown function
K10K4_27900	COG1530	ribonuclease E activity
K10K4_27910	COG0424	maF-like protein
K10K4_27920	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K10K4_27930	COG1792	Involved in formation and maintenance of cell shape
K10K4_27940	COG1077	Cell shape determining protein MreB Mrl
K10K4_28030	COG1459	type II secretion system
K10K4_28040	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K10K4_28060	COG3409	Peptidoglycan-binding domain 1 protein
K10K4_28060	COG3267	Type II secretory pathway component ExeA
K10K4_28070	COG1450	Type ii and iii secretion system protein
K10K4_28110	COG2200	EAL domain
K10K4_28110	COG2199	diguanylate cyclase activity
K10K4_28120	COG0629	single-stranded DNA binding
K10K4_28220	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K10K4_28330	COG1530	ribonuclease E activity
K10K4_28340	COG0424	maF-like protein
K10K4_28350	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K10K4_28360	COG1792	Involved in formation and maintenance of cell shape
K10K4_28370	COG1077	Cell shape determining protein MreB Mrl
K10K4_28450	COG1459	type II secretion system
K10K4_28460	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K10K4_28480	COG3267	Type II secretory pathway component ExeA
K10K4_28480	COG3409	Peptidoglycan-binding domain 1 protein
K10K4_28490	COG1450	Type ii and iii secretion system protein
K10K4_28530	COG2199	diguanylate cyclase activity
K10K4_28530	COG2200	EAL domain
K10K4_28540	COG0629	single-stranded DNA binding
K10K4_28570	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K10K4_28610	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K10K4_28620	COG0527	aspartate kinase activity
K10K4_28630	COG0646	methionine synthase
K10K4_28630	COG1410	methionine synthase
K10K4_28760	COG0175	sulfate reduction
K10K4_28770	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K10K4_28780	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K10K4_28820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K10K4_28830	COG0735	belongs to the Fur family
K10K4_28850	COG0166	Belongs to the GPI family
K10K4_28860	COG0432	Pfam Uncharacterised protein family UPF0047
K10K4_28870	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K10K4_28880	COG0305	Participates in initiation and elongation during chromosome replication
K10K4_28920	COG2965	DNA replication, synthesis of RNA primer
K10K4_28930	COG0360	Binds together with S18 to 16S ribosomal RNA
K10K4_28940	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K10K4_28950	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K10K4_28970	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K10K4_28980	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K10K4_29040	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K10K4_29060	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K10K4_29060	COG0678	peroxiredoxin activity
K10K4_29070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K10K4_29100	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K10K4_29100	COG0165	Argininosuccinate lyase
K10K4_29110	COG0137	argininosuccinate synthase activity
K10K4_29130	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K10K4_29150	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K10K4_29170	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K10K4_29180	COG0460	homoserine dehydrogenase
K10K4_29180	COG0527	aspartate kinase activity
K10K4_29190	COG0626	cystathionine gamma-synthase activity
K10K4_29210	COG0281	malic enzyme
K10K4_29230	COG2906	2 iron, 2 sulfur cluster binding
K10K4_29240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K10K4_29250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K10K4_29290	COG2923	Belongs to the DsrF TusC family
K10K4_29300	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
K10K4_29310	COG2964	Protein conserved in bacteria
K10K4_29320	COG0545	Peptidyl-prolyl cis-trans isomerase
K10K4_29350	COG1446	asparaginase
K10K4_29360	COG1047	Peptidyl-prolyl cis-trans
K10K4_29390	COG2249	NAD(P)H dehydrogenase (quinone) activity
K10K4_29400	COG0488	(ABC) transporter
K10K4_29420	COG0429	hydrolase of the alpha beta-hydrolase fold
K10K4_29440	COG3954	Phosphoribulokinase
K10K4_29450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K10K4_29490	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K10K4_29500	COG0512	Glutamine amidotransferase of anthranilate synthase
K10K4_29530	COG0180	Tryptophanyl-tRNA synthetase
K10K4_29540	COG0546	phosphoglycolate phosphatase activity
K10K4_29550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K10K4_29560	COG0557	exoribonuclease II activity
K10K4_29570	COG1959	2 iron, 2 sulfur cluster binding
K10K4_29580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K10K4_29580	COG1017	nitric oxide dioxygenase activity
K10K4_29590	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
K10K4_29600	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K10K4_29610	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
K10K4_29620	COG0330	HflC and HflK could
K10K4_29630	COG0330	HflC and HflK could
K10K4_29640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K10K4_29660	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K10K4_29670	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K10K4_29690	COG0802	atpase or kinase
K10K4_29710	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K10K4_29840	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K10K4_29850	COG1162	GTPase activity
K10K4_29860	COG0688	phosphatidylethanolamine metabolic process
K10K4_29870	COG0471	metal ion transport
K10K4_29890	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K10K4_29900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K10K4_29910	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K10K4_29920	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K10K4_29930	COG1045	serine acetyltransferase
K10K4_29940	COG4942	peptidase
K10K4_29980	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K10K4_29990	COG1053	succinate dehydrogenase
K10K4_30000	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K10K4_30010	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K10K4_30020	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K10K4_30050	COG1509	lysine 2,3-aminomutase activity
K10K4_30060	COG1285	pathogenesis
K10K4_30080	COG0459	protein refolding
K10K4_30090	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K10K4_30100	COG0534	Mate efflux family protein
K10K4_30110	COG0205	6-phosphofructokinase activity
K10K4_30120	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K10K4_30130	COG3678	ATP-independent chaperone mediated protein folding
K10K4_30140	COG0745	RESPONSE REGULATOR receiver
K10K4_30150	COG2205	protein histidine kinase activity
K10K4_30170	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K10K4_30180	COG3030	protein affecting phage T7 exclusion by the F plasmid
K10K4_30190	COG1027	Aspartate ammonia-lyase
K10K4_30200	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K10K4_30210	COG4232	protein-disulfide reductase activity
K10K4_30230	COG3263	regulation of cellular component size
K10K4_30250	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K10K4_30300	COG2814	Major facilitator Superfamily
K10K4_30330	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K10K4_30340	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K10K4_30350	COG0511	ligase activity, forming carbon-carbon bonds
K10K4_30360	COG0439	Biotin carboxylase
K10K4_30370	COG2264	protein methyltransferase activity
K10K4_30380	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K10K4_30390	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K10K4_30410	COG0488	(ABC) transporter
K10K4_30510	COG1982	Orn Lys Arg decarboxylase major
K10K4_30520	COG0531	amino acid
K10K4_30530	COG3710	Transcriptional regulator
K10K4_30540	COG0789	Transcriptional regulator
K10K4_30560	COG0151	Belongs to the GarS family
K10K4_30590	COG1253	flavin adenine dinucleotide binding
K10K4_30600	COG3068	Protein conserved in bacteria
K10K4_30620	COG1573	uracil-dna glycosylase
K10K4_30630	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K10K4_30640	COG2816	NAD+ diphosphatase activity
K10K4_30650	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
K10K4_30660	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K10K4_30670	COG0085	RNA polymerase activity
K10K4_30680	COG0222	ribosome binding
K10K4_30690	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K10K4_30720	COG0250	Participates in transcription elongation, termination and antitermination
K10K4_30730	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K10K4_30740	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K10K4_30800	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K10K4_30800	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K10K4_30810	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K10K4_30830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K10K4_31000	COG4206	TonB-dependent receptor
K10K4_31040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K10K4_31050	COG0534	Mate efflux family protein
K10K4_31060	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K10K4_31070	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K10K4_31080	COG2937	Belongs to the GPAT DAPAT family
K10K4_31090	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K10K4_31100	COG3161	chorismate lyase activity
K10K4_31110	COG1580	Controls the rotational direction of flagella during chemotaxis
K10K4_31120	COG0705	Rhomboid family
K10K4_31130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K10K4_31150	COG2177	Part of the ABC transporter FtsEX involved in
K10K4_31160	COG2884	Cell division ATP-binding protein ftsE
K10K4_31170	COG0552	protein localization to endoplasmic reticulum
K10K4_31180	COG0742	ribosomal rna small subunit methyltransferase
K10K4_31200	COG2095	MarC family integral membrane protein
K10K4_31280	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K10K4_31290	COG0640	Transcriptional regulator
K10K4_31300	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K10K4_31310	COG1280	lysine exporter protein (LysE YggA)
K10K4_31320	COG2267	carboxylic ester hydrolase activity
K10K4_31330	COG0561	phosphatase activity
K10K4_31370	COG2199	diguanylate cyclase activity
K10K4_31370	COG2200	EAL domain
K10K4_31370	COG3287	FIST C domain
K10K4_31380	COG1011	Hydrolase
K10K4_31390	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K10K4_31420	COG0019	diaminopimelate decarboxylase activity
K10K4_31430	COG1965	Belongs to the frataxin family
K10K4_31440	COG3072	Adenylate cyclase
K10K4_31450	COG0181	hydroxymethylbilane synthase activity
K10K4_31460	COG1587	Uroporphyrinogen-III synthase
K10K4_31470	COG2959	enzyme of heme biosynthesis
K10K4_31480	COG3071	HemY protein
K10K4_31570	COG0633	Ferredoxin
K10K4_31580	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K10K4_31600	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K10K4_31610	COG3118	belongs to the thioredoxin family
K10K4_31620	COG0513	Belongs to the DEAD box helicase family
K10K4_31630	COG0248	Ppx GppA phosphatase
K10K4_31650	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K10K4_31670	COG0514	ATP-dependent DNA helicase (RecQ)
K10K4_31680	COG2962	Rard protein
K10K4_31700	COG1280	lysine exporter protein (LysE YggA)
K10K4_31710	COG0405	Gamma-glutamyltransferase
K10K4_31720	COG0210	DNA helicase
K10K4_31740	COG3220	belongs to the UPF0276 family
K10K4_31800	COG0006	proline dipeptidase activity
K10K4_31800	COG0006	proline dipeptidase activity
K10K4_31830	COG2104	thiamine diphosphate biosynthetic process
K10K4_31840	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K10K4_31880	COG2132	Multicopper oxidase
K10K4_31980	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K10K4_32020	COG0009	L-threonylcarbamoyladenylate synthase
K10K4_32030	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K10K4_32040	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K10K4_32050	COG0551	DNA topoisomerase type I activity
K10K4_32060	COG2922	Belongs to the Smg family
K10K4_32070	COG0758	DNA mediated transformation
K10K4_32090	COG0242	peptide deformylase activity
K10K4_32100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K10K4_32110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K10K4_32110	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K10K4_32120	COG0569	domain protein
K10K4_32130	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K10K4_32150	COG1272	protein, Hemolysin III
K10K4_32160	COG4326	sporulation control protein
K10K4_32180	COG3084	Protein conserved in bacteria
K10K4_32200	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K10K4_32210	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K10K4_32220	COG0204	Acyl-transferase
K10K4_32240	COG0606	chelatase, subunit chli
K10K4_32260	COG3978	acetolactate synthase activity
K10K4_32270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K10K4_32280	COG0129	dihydroxy-acid dehydratase activity
K10K4_32300	COG0583	DNA-binding transcription factor activity
K10K4_32310	COG2814	Major facilitator Superfamily
K10K4_32330	COG0765	amino acid transport
K10K4_32360	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K10K4_32370	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K10K4_32380	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K10K4_32390	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K10K4_32400	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K10K4_32410	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K10K4_32430	COG0356	it plays a direct role in the translocation of protons across the membrane
K10K4_32440	COG3312	ion transport
K10K4_32450	COG1475	DNA binding
K10K4_32460	COG1192	Involved in chromosome partitioning
K10K4_32470	COG0357	Ribosomal RNA small subunit methyltransferase G
K10K4_32480	COG0445	tRNA wobble uridine modification
K10K4_32490	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K10K4_32510	COG0706	membrane insertase activity
K10K4_32520	COG0594	ribonuclease P activity
K10K4_32540	COG1126	abc transporter atp-binding protein
K10K4_32590	COG1444	tRNA N-acetyltransferase activity
K10K4_32630	COG3340	Belongs to the peptidase S51 family
K10K4_32640	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K10K4_32650	COG1263	PTS System
K10K4_32650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K10K4_32660	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K10K4_32690	COG4166	transmembrane transport
K10K4_32790	COG0259	pyridoxamine-phosphate oxidase activity
K10K4_32840	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K10K4_32920	COG1132	(ABC) transporter
K10K4_32940	COG0513	Belongs to the DEAD box helicase family
K10K4_32950	COG2258	MOSC domain
K10K4_33040	COG3634	alkyl hydroperoxide reductase activity
K10K4_33050	COG0450	alkyl hydroperoxide reductase
K10K4_33130	COG1846	Transcriptional regulator
K10K4_33140	COG1764	response to oxidative stress
K10K4_33220	COG1136	(ABC) transporter
K10K4_33270	COG0745	RESPONSE REGULATOR receiver
K10K4_33290	COG1653	transport
K10K4_33300	COG0019	diaminopimelate decarboxylase activity
K10K4_33310	COG4264	IucA IucC family
K10K4_33360	COG4772	TonB-dependent receptor
K10K4_33370	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K10K4_33380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K10K4_33390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K10K4_33400	COG1120	ATPase activity
K10K4_33410	COG0840	transmembrane signaling receptor activity
K10K4_33420	COG0612	Peptidase, M16
K10K4_33440	COG0739	heme binding
K10K4_33470	COG2814	Major facilitator Superfamily
K10K4_33490	COG1609	Transcriptional regulator
K10K4_33500	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K10K4_33550	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K10K4_33560	COG1609	Transcriptional regulator
K10K4_33610	COG0596	Alpha beta hydrolase
K10K4_33660	COG1760	l-serine dehydratase
K10K4_33680	COG4580	involved in the transport of maltose and maltodextrins
K10K4_33720	COG2356	endonuclease I
K10K4_33760	COG1982	Orn Lys Arg decarboxylase major
K10K4_33770	COG0531	amino acid
K10K4_33790	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K10K4_33800	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
K10K4_33810	COG1162	GTPase activity
K10K4_33820	COG1263	PTS System
K10K4_33820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K10K4_33830	COG1999	signal sequence binding
K10K4_33860	COG2909	trisaccharide binding
K10K4_33870	COG0058	SHG alpha-glucan phosphorylase activity
K10K4_33880	COG1640	4-alpha-glucanotransferase
K10K4_33890	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K10K4_33900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K10K4_33910	COG0366	Alpha amylase catalytic
K10K4_33930	COG3366	ferrous iron transmembrane transporter activity
K10K4_33940	COG0700	Nucleoside recognition
K10K4_33950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K10K4_33960	COG3339	Conserved Protein
K10K4_33970	COG1301	dicarboxylic acid transport
K10K4_33990	COG0583	DNA-binding transcription factor activity
K10K4_34040	COG1596	polysaccharide export
K10K4_34070	COG2095	MarC family integral membrane protein
K10K4_34080	COG4667	esterase of the alpha-beta hydrolase superfamily
K10K4_34090	COG3397	chitin binding
K10K4_34100	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K10K4_34110	COG0415	Belongs to the DNA photolyase family
K10K4_34150	COG1686	Belongs to the peptidase S11 family
K10K4_34200	COG0583	DNA-binding transcription factor activity
K10K4_34210	COG4628	conserved protein (DUF2132)
K10K4_34260	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K10K4_34270	COG0628	permease
K10K4_34320	COG1289	transmembrane transporter activity
K10K4_34350	COG2814	Major facilitator Superfamily
K10K4_34370	COG0454	-acetyltransferase
K10K4_34390	COG0745	RESPONSE REGULATOR receiver
K10K4_34400	COG2205	protein histidine kinase activity
K10K4_34430	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K10K4_34440	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K10K4_34520	COG1360	Flagellar Motor Protein
K10K4_34530	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K10K4_34540	COG1191	sigma factor activity
K10K4_34550	COG1580	Controls the rotational direction of flagella during chemotaxis
K10K4_34580	COG1516	flagellar protein fliS
K10K4_34590	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K10K4_34610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K10K4_34640	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K10K4_34660	COG1987	bacterial-type flagellum assembly
K10K4_34710	COG2204	response regulator
K10K4_34740	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K10K4_34850	COG0346	lactoylglutathione lyase activity
K10K4_34900	COG0745	RESPONSE REGULATOR receiver
K10K4_34950	COG3300	MHYT domain
K10K4_34950	COG5001	Diguanylate cyclase
K10K4_34960	COG0156	8-amino-7-oxononanoate synthase activity
K10K4_34970	COG1063	alcohol dehydrogenase
K10K4_35040	COG0668	transmembrane transport
K10K4_35060	COG1304	FMN binding
K10K4_35070	COG1620	l-lactate permease
K10K4_35080	COG0583	DNA-binding transcription factor activity
K10K4_35090	COG1505	serine-type exopeptidase activity
K10K4_35100	COG4172	Belongs to the ABC transporter superfamily
K10K4_35120	COG1067	ATP-dependent peptidase activity
K10K4_35140	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K10K4_35180	COG1247	-acetyltransferase
K10K4_35190	COG0437	4 iron, 4 sulfur cluster binding
K10K4_35200	COG0348	domain, Protein
K10K4_35240	COG1122	ATPase activity
K10K4_35250	COG4720	Psort location CytoplasmicMembrane, score
K10K4_35260	COG1566	PFAM secretion protein HlyD family protein
K10K4_35280	COG3706	GGDEF domain
K10K4_35310	COG0813	purine-nucleoside phosphorylase activity
K10K4_35320	COG3272	Protein of unknown function (DUF1722)
K10K4_35330	COG0789	Transcriptional regulator
K10K4_35340	COG0415	Belongs to the DNA photolyase family
K10K4_35350	COG1388	LysM domain
K10K4_35350	COG1376	ErfK ybiS ycfS ynhG family protein
K10K4_35370	COG0513	Belongs to the DEAD box helicase family
K10K4_35380	COG1770	oligopeptidase
K10K4_35390	COG4771	TonB-dependent receptor
K10K4_35440	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K10K4_35450	COG0573	inorganic phosphate transmembrane transporter activity
K10K4_35460	COG0581	inorganic phosphate transmembrane transporter activity
K10K4_35470	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K10K4_35500	COG2304	oxidoreductase activity
K10K4_35540	COG0714	Associated with various cellular activities
K10K4_35570	COG2197	response regulator
K10K4_35640	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K10K4_35650	COG1120	ATPase activity
K10K4_35660	COG4774	siderophore transport
K10K4_35670	COG1132	(ABC) transporter
K10K4_35700	COG0569	domain protein
K10K4_35710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K10K4_35720	COG0583	DNA-binding transcription factor activity
K10K4_35760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K10K4_35770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K10K4_35790	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
K10K4_35800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K10K4_35860	COG2084	Dehydrogenase
K10K4_35870	COG0753	catalase activity
K10K4_35890	COG2130	NADP-dependent
K10K4_35900	COG1309	transcriptional regulator
K10K4_35990	COG3206	protein involved in exopolysaccharide biosynthesis
K10K4_35990	COG0489	protein tyrosine kinase activity
K10K4_36020	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K10K4_36030	COG3842	ATPase activity
K10K4_36050	COG1175	transmembrane transport
K10K4_36060	COG3833	ABC-type maltose transport systems, permease component
K10K4_36120	COG2354	Protein conserved in bacteria
K10K4_36130	COG0418	dihydroorotase activity
K10K4_36140	COG0401	homolog of Blt101
K10K4_36150	COG3217	Mosc domain protein beta barrel domain protein
K10K4_36150	COG3217	Mosc domain protein beta barrel domain protein
K10K4_36150	COG0633	Ferredoxin
K10K4_36150	COG0633	Ferredoxin
K10K4_36170	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K10K4_36250	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K10K4_36260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K10K4_36280	COG0848	biopolymer transport protein
K10K4_36290	COG0811	peptide transport
K10K4_36300	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K10K4_36320	COG3721	Heme iron utilization protein
K10K4_36330	COG0748	coenzyme F420 binding
K10K4_36350	COG0835	chemotaxis
K10K4_36350	COG0784	Response regulator, receiver
K10K4_36360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K10K4_36370	COG0534	Mate efflux family protein
K10K4_36380	COG0444	Belongs to the ABC transporter superfamily
K10K4_36390	COG4608	Belongs to the ABC transporter superfamily
K10K4_36400	COG0747	negative chemotaxis
K10K4_36420	COG1349	DNA-binding transcription factor activity
K10K4_36430	COG2084	Dehydrogenase
K10K4_36440	COG3395	kinase activity
K10K4_36450	COG0235	Class ii aldolase
K10K4_36460	COG3622	Belongs to the hyi family
K10K4_36470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K10K4_36480	COG2610	gluconate transmembrane transporter activity
K10K4_36520	COG0583	DNA-binding transcription factor activity
K10K4_36530	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K10K4_36550	COG4934	collagen metabolic process
K10K4_36570	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K10K4_36580	COG0789	Transcriptional regulator
K10K4_36590	COG0366	Alpha amylase catalytic
K10K4_36630	COG2249	NAD(P)H dehydrogenase (quinone) activity
K10K4_36640	COG0589	response to stress
K10K4_36650	COG0488	(ABC) transporter
K10K4_36660	COG1505	serine-type exopeptidase activity
K10K4_36680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K10K4_36700	COG2067	long-chain fatty acid transport protein
K10K4_36720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K10K4_36770	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K10K4_36810	COG3383	formate dehydrogenase (NAD+) activity
K10K4_36830	COG0842	Transport permease protein
K10K4_36840	COG1131	(ABC) transporter
K10K4_36880	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
K10K4_36900	COG4145	pantothenate transmembrane transporter activity
K10K4_36910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K10K4_36920	COG0800	Aldolase
K10K4_36940	COG2706	6-phosphogluconolactonase activity
K10K4_36950	COG0251	oxidation-reduction process
K10K4_36970	COG1881	PFAM PEBP family protein
K10K4_36990	COG0798	PFAM Bile acid sodium symporter
K10K4_37020	COG1733	regulation of RNA biosynthetic process
K10K4_37080	COG4989	oxidoreductase activity
K10K4_37130	COG0814	amino acid
K10K4_37200	COG0739	heme binding
K10K4_37210	COG5001	Diguanylate cyclase
K10K4_37220	COG0583	DNA-binding transcription factor activity
K10K4_37230	COG2814	Major facilitator Superfamily
K10K4_37270	COG0697	spore germination
K10K4_37300	COG0179	Fumarylacetoacetate (FAA) hydrolase
K10K4_37340	COG1280	lysine exporter protein (LysE YggA)
K10K4_37360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K10K4_37370	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K10K4_37390	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K10K4_37400	COG1845	cytochrome c oxidase, subunit III
K10K4_37430	COG1612	heme a metabolic process
K10K4_37440	COG0109	protoheme IX farnesyltransferase activity
K10K4_37450	COG0545	Peptidyl-prolyl cis-trans isomerase
K10K4_37510	COG1278	Cold shock
K10K4_37520	COG3036	rescue of stalled ribosome
K10K4_37530	COG2199	diguanylate cyclase activity
K10K4_37560	COG1132	(ABC) transporter
K10K4_37570	COG1132	(ABC) transporter
K10K4_37580	COG1538	Outer membrane efflux protein
K10K4_37590	COG2205	protein histidine kinase activity
K10K4_37590	COG0784	Response regulator, receiver
K10K4_37640	COG0840	transmembrane signaling receptor activity
K10K4_37660	COG0783	Belongs to the Dps family
K10K4_37680	COG2133	pyrroloquinoline quinone binding
K10K4_37690	COG1454	alcohol dehydrogenase
K10K4_37700	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
K10K4_37750	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K10K4_37760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K10K4_37770	COG3186	Phenylalanine-4-hydroxylase
K10K4_37820	COG3530	Putative quorum-sensing-regulated virulence factor
K10K4_37860	COG0513	Belongs to the DEAD box helicase family
K10K4_37870	COG4628	conserved protein (DUF2132)
K10K4_37890	COG0133	tryptophan synthase activity
K10K4_37900	COG1278	Cold shock
K10K4_37920	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
K10K4_37940	COG0523	cobalamin synthesis protein
K10K4_37950	COG0513	Belongs to the DEAD box helicase family
K10K4_37990	COG2200	EAL domain
K10K4_38000	COG1119	ATPase activity
K10K4_38040	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K10K4_38070	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
K10K4_38080	COG0513	Belongs to the DEAD box helicase family
K10K4_38090	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K10K4_38110	COG1073	alpha beta
K10K4_38120	COG1073	alpha beta
K10K4_38150	COG0730	response to heat
K10K4_38180	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K10K4_38200	COG0523	cobalamin synthesis protein
K10K4_38210	COG2988	succinylglutamate desuccinylase activity
K10K4_38220	COG0739	heme binding
K10K4_38240	COG0523	cobalamin synthesis protein
K10K4_38260	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K10K4_38270	COG2095	MarC family integral membrane protein
K10K4_38320	COG1024	Enoyl-CoA hydratase
K10K4_38330	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K10K4_38340	COG1960	acyl-CoA dehydrogenase activity
K10K4_38360	COG0183	Belongs to the thiolase family
K10K4_38390	COG1024	Enoyl-CoA hydratase
K10K4_38400	COG1024	Enoyl-CoA hydratase
K10K4_38420	COG1028	Short-chain dehydrogenase reductase Sdr
K10K4_38430	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K10K4_38440	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K10K4_38450	COG1845	cytochrome c oxidase, subunit III
K10K4_38460	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K10K4_38470	COG0109	protoheme IX farnesyltransferase activity
K10K4_38480	COG1902	pentaerythritol trinitrate reductase activity
K10K4_38480	COG0446	pyridine nucleotide-disulphide oxidoreductase
K10K4_38510	COG1012	belongs to the aldehyde dehydrogenase family
K10K4_38530	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K10K4_38590	COG1126	abc transporter atp-binding protein
K10K4_38600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K10K4_38610	COG4215	(ABC) transporter
K10K4_38620	COG4160	amino acid transport
K10K4_38760	COG0443	Heat shock 70 kDa protein
K10K4_38770	COG2847	Copper chaperone PCu(A)C
K10K4_38880	COG3706	GGDEF domain
K10K4_38900	COG0814	amino acid
K10K4_38920	COG0243	molybdopterin cofactor binding
K10K4_38960	COG3707	response regulator
K10K4_38970	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K10K4_38970	COG1116	anion transmembrane transporter activity
K10K4_38980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K10K4_38990	COG1116	anion transmembrane transporter activity
K10K4_39000	COG2146	nitrite reductase [NAD(P)H] activity
K10K4_39000	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K10K4_39100	COG0515	serine threonine protein kinase
K10K4_39100	COG2815	serine threonine protein kinase
K10K4_39170	COG0631	protein serine/threonine phosphatase activity
K10K4_39280	COG3501	Rhs element vgr protein
K10K4_39310	COG0420	3'-5' exonuclease activity
K10K4_39320	COG0419	ATPase involved in DNA repair
K10K4_39340	COG3040	lipid binding
K10K4_39360	COG1288	antiporter activity
K10K4_39380	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
K10K4_39410	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K10K4_39440	COG0583	DNA-binding transcription factor activity
K10K4_39450	COG0277	FAD linked oxidase domain protein
K10K4_39480	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K10K4_39550	COG2176	DNA-directed DNA polymerase activity
K10K4_39640	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
K10K4_39650	COG1328	CTP reductase activity
K10K4_40100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K10K4_40140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K10K4_40160	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K10K4_40170	COG2146	nitrite reductase [NAD(P)H] activity
K10K4_40180	COG2116	formate transmembrane transporter activity
K10K4_40220	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K10K4_40280	COG2814	Major facilitator Superfamily
K10K4_40290	COG3118	belongs to the thioredoxin family
K10K4_40300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K10K4_40350	COG2271	Major facilitator Superfamily
K10K4_40360	COG3851	Histidine kinase
K10K4_40370	COG2197	response regulator
K10K4_40390	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K10K4_40400	COG0583	DNA-binding transcription factor activity
K10K4_40410	COG0243	molybdopterin cofactor binding
K10K4_40440	COG0384	phenazine biosynthesis protein PhzF
K10K4_40450	COG1794	racemase activity, acting on amino acids and derivatives
K10K4_40510	COG1328	CTP reductase activity
K10K4_40520	COG0602	queuosine metabolic process
K10K4_40530	COG0534	Mate efflux family protein
K10K4_40540	COG2207	Transcriptional regulator
K10K4_40560	COG4067	protein conserved in archaea
K10K4_40560	COG0189	ligase activity
K10K4_40580	COG3111	PFAM Bacterial OB fold (BOF) protein
K10K4_40600	COG0725	ABC transporter, periplasmic molybdate-binding protein
K10K4_40610	COG4149	molybdate abc transporter
K10K4_40620	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K10K4_40640	COG2203	Gaf domain
K10K4_40640	COG5001	Diguanylate cyclase
K10K4_40640	COG3706	GGDEF domain
K10K4_40640	COG4251	negative regulation of phosphorylation
K10K4_40650	COG3706	GGDEF domain
K10K4_40650	COG0745	RESPONSE REGULATOR receiver
K10K4_40680	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K10K4_40690	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K10K4_40740	COG3140	Belongs to the UPF0181 family
K10K4_40770	COG0583	DNA-binding transcription factor activity
K10K4_41070	COG0023	Translation Initiation Factor
K10K4_41090	COG1181	Belongs to the D-alanine--D-alanine ligase family
K10K4_41110	COG1042	CoA-binding domain protein
K10K4_41110	COG0045	succinate-CoA ligase (ADP-forming) activity
K10K4_41110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K10K4_41120	COG0583	DNA-binding transcription factor activity
K10K4_41150	COG5002	protein histidine kinase activity
K10K4_41150	COG5001	Diguanylate cyclase
K10K4_41150	COG3447	MASE1 domain protein
K10K4_41160	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K10K4_41170	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K10K4_41180	COG1984	allophanate hydrolase subunit 2
K10K4_41260	COG4181	ATPase activity
K10K4_41270	COG4181	ATPase activity
K10K4_41370	COG4128	Pfam Zonular occludens toxin
K10K4_41520	COG0045	succinate-CoA ligase (ADP-forming) activity
K10K4_41520	COG1042	CoA-binding domain protein
K10K4_41520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K10K4_41530	COG0583	DNA-binding transcription factor activity
K10K4_41560	COG5001	Diguanylate cyclase
K10K4_41560	COG3447	MASE1 domain protein
K10K4_41560	COG5002	protein histidine kinase activity
K10K4_41570	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K10K4_41580	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K10K4_41590	COG1984	allophanate hydrolase subunit 2
K10K4_41610	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K10K4_41620	COG4181	ATPase activity
K10K4_41640	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K10K4_41650	COG5001	Diguanylate cyclase
K10K4_41650	COG3300	MHYT domain
K10K4_41720	COG4533	DNA binding
K10K4_41740	COG2050	protein possibly involved in aromatic compounds catabolism
K10K4_41770	COG2067	long-chain fatty acid transport protein
K10K4_41780	COG2267	carboxylic ester hydrolase activity
K10K4_41820	COG0861	Integral membrane protein TerC family
K10K4_41830	COG0737	Belongs to the 5'-nucleotidase family
K10K4_41840	COG3593	DNA synthesis involved in DNA repair
K10K4_41860	COG0583	DNA-binding transcription factor activity
K10K4_41880	COG2116	formate transmembrane transporter activity
K10K4_41890	COG2353	YceI-like domain
K10K4_41900	COG3038	cytochrome b561
K10K4_41940	COG0513	Belongs to the DEAD box helicase family
K10K4_41950	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
K10K4_41970	COG0840	transmembrane signaling receptor activity
K10K4_41980	COG0546	phosphoglycolate phosphatase activity
K10K4_42010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K10K4_42020	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K10K4_42030	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K10K4_42050	COG2207	Transcriptional regulator
K10K4_42060	COG1979	alcohol dehydrogenase
K10K4_42080	COG1126	abc transporter atp-binding protein
K10K4_42090	COG0765	amino acid transport
K10K4_42100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K10K4_42110	COG0765	amino acid transport
K10K4_42120	COG2199	diguanylate cyclase activity
K10K4_42120	COG2200	EAL domain
K10K4_42120	COG2203	Gaf domain
K10K4_42150	COG1609	Transcriptional regulator
K10K4_42160	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K10K4_42160	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K10K4_42170	COG1105	Belongs to the carbohydrate kinase PfkB family
K10K4_42180	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K10K4_42180	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K10K4_42180	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
K10K4_42240	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K10K4_42260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K10K4_42270	COG0509	glycine decarboxylation via glycine cleavage system
K10K4_42290	COG0346	lactoylglutathione lyase activity
K10K4_42300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K10K4_42310	COG0583	DNA-binding transcription factor activity
K10K4_42320	COG0697	spore germination
K10K4_42330	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K10K4_42390	COG2176	DNA-directed DNA polymerase activity
K10K4_42470	COG0242	peptide deformylase activity
K10K4_42530	COG2239	Acts as a magnesium transporter
K10K4_42570	COG0346	lactoylglutathione lyase activity
K10K4_42580	COG1902	pentaerythritol trinitrate reductase activity
K10K4_42600	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K10K4_42600	COG2755	lipolytic protein G-D-S-L family
K10K4_42630	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K10K4_42640	COG0069	glutamate synthase activity
K10K4_42640	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K10K4_42700	COG2076	Multidrug Resistance protein
K10K4_42740	COG2962	Rard protein
K10K4_42770	COG0835	chemotaxis
K10K4_42770	COG0784	Response regulator, receiver
K10K4_42780	COG2197	response regulator
K10K4_42800	COG3706	GGDEF domain
K10K4_42810	COG2197	response regulator
K10K4_42820	COG3300	MHYT domain
K10K4_42820	COG5001	Diguanylate cyclase
K10K4_42830	COG2205	protein histidine kinase activity
K10K4_42830	COG0784	Response regulator, receiver
K10K4_42840	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K10K4_42880	COG0456	acetyltransferase
K10K4_42880	COG1214	PFAM Peptidase M22, glycoprotease
K10K4_42900	COG3069	C4-dicarboxylate transmembrane transporter activity
K10K4_42950	COG3111	PFAM Bacterial OB fold (BOF) protein
K10K4_42960	COG1597	lipid kinase activity
K10K4_42970	COG0583	DNA-binding transcription factor activity
K10K4_42980	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K10K4_43040	COG0714	Associated with various cellular activities
K10K4_43050	COG0641	radical SAM
K10K4_43060	COG3119	arylsulfatase activity
K10K4_43080	COG3119	arylsulfatase activity
K10K4_43090	COG0745	RESPONSE REGULATOR receiver
K10K4_43120	COG2198	Histidine kinase
K10K4_43120	COG2205	protein histidine kinase activity
K10K4_43120	COG0784	Response regulator, receiver
K10K4_43130	COG1879	ABC-type sugar transport system periplasmic component
K10K4_43140	COG1803	Methylglyoxal synthase
K10K4_43150	COG0210	DNA helicase
K10K4_43160	COG1289	transmembrane transporter activity
K10K4_43220	COG4771	TonB-dependent receptor
K10K4_43220	COG1629	transport
K10K4_43240	COG0789	Transcriptional regulator
K10K4_43250	COG4604	ABC transporter, ATP-binding protein
K10K4_43260	COG4605	iron ion homeostasis
K10K4_43270	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K10K4_43280	COG4607	ABC-type enterochelin transport system periplasmic component
K10K4_43300	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
K10K4_43330	COG1609	Transcriptional regulator
K10K4_43340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K10K4_43350	COG1879	ABC-type sugar transport system periplasmic component
K10K4_43360	COG1172	Belongs to the binding-protein-dependent transport system permease family
K10K4_43370	COG1129	ABC transporter
K10K4_43380	COG1869	D-ribose catabolic process
K10K4_43390	COG5001	Diguanylate cyclase
K10K4_43490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K10K4_43510	COG2205	protein histidine kinase activity
K10K4_43510	COG0784	Response regulator, receiver
K10K4_43540	COG0330	HflC and HflK could
K10K4_43570	COG4175	Glycine betaine
K10K4_43570	COG0517	IMP dehydrogenase activity
K10K4_43580	COG4176	ABC-type proline glycine betaine transport system permease component
K10K4_43610	COG1012	belongs to the aldehyde dehydrogenase family
K10K4_43620	COG1309	transcriptional regulator
K10K4_43630	COG0745	RESPONSE REGULATOR receiver
K10K4_43630	COG3706	GGDEF domain
K10K4_43640	COG1028	Short-chain dehydrogenase reductase Sdr
K10K4_43670	COG1024	Enoyl-CoA hydratase
K10K4_43680	COG1960	acyl-CoA dehydrogenase activity
K10K4_43700	COG0183	Belongs to the thiolase family
K10K4_43720	COG1960	acyl-CoA dehydrogenase activity
K10K4_43730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K10K4_43780	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K10K4_43780	COG3264	Mechanosensitive ion channel
K10K4_43790	COG0110	maltose O-acetyltransferase activity
K10K4_43800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K10K4_43810	COG1271	oxidase subunit
K10K4_43820	COG1294	oxidase, subunit
K10K4_43840	COG0384	phenazine biosynthesis protein PhzF
K10K4_43880	COG3527	Alpha-acetolactate decarboxylase
K10K4_43900	COG1028	Short-chain dehydrogenase reductase Sdr
K10K4_43910	COG0500	methyltransferase
K10K4_43970	COG1022	Amp-dependent synthetase and ligase
K10K4_44020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K10K4_44030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K10K4_44030	COG1263	PTS System
K10K4_44040	COG1486	melibiose metabolic process
K10K4_44050	COG2188	Transcriptional regulator
K10K4_44060	COG1320	monovalent cation:proton antiporter activity
K10K4_44070	COG2212	antiporter activity
K10K4_44100	COG1006	Multisubunit Na H antiporter MnhC subunit
K10K4_44110	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K10K4_44110	COG2111	Na H antiporter
K10K4_44130	COG0589	response to stress
K10K4_44140	COG4221	oxidoreductase activity
K10K4_44150	COG0583	DNA-binding transcription factor activity
K10K4_44170	COG2814	Major facilitator Superfamily
K10K4_44300	COG1522	sequence-specific DNA binding
K10K4_44370	COG0515	serine threonine protein kinase
K10K4_44420	COG3501	Rhs element vgr protein
K10K4_44450	COG2204	response regulator
K10K4_44500	COG0739	heme binding
K10K4_44530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K10K4_44630	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K10K4_44650	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K10K4_44650	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K10K4_44680	COG4989	oxidoreductase activity
K10K4_44710	COG0038	chloride channel
K10K4_44780	COG2897	thiosulfate sulfurtransferase activity
K10K4_44800	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K10K4_44810	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K10K4_44820	COG0840	transmembrane signaling receptor activity
K10K4_44830	COG2814	Major facilitator Superfamily
K10K4_44840	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K10K4_44860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K10K4_44880	COG0840	transmembrane signaling receptor activity
K10K4_44920	COG2195	Cleaves the N-terminal amino acid of tripeptides
K10K4_44950	COG2197	response regulator
K10K4_44960	COG3850	Histidine kinase
K10K4_44970	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K10K4_44990	COG0243	molybdopterin cofactor binding
K10K4_45010	COG3005	denitrification pathway
K10K4_45030	COG3243	poly(R)-hydroxyalkanoic acid synthase
K10K4_45050	COG0183	Belongs to the thiolase family
K10K4_45070	COG1280	lysine exporter protein (LysE YggA)
K10K4_45090	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K10K4_45100	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K10K4_45200	COG1846	Transcriptional regulator
K10K4_45210	COG0784	Response regulator, receiver
K10K4_45210	COG2205	protein histidine kinase activity
K10K4_45220	COG1879	ABC-type sugar transport system periplasmic component
K10K4_45230	COG2827	Endonuclease containing a URI domain
K10K4_45240	COG3132	Protein of unknown function, DUF480
K10K4_45280	COG0784	Response regulator, receiver
K10K4_45280	COG2205	protein histidine kinase activity
K10K4_45280	COG5002	protein histidine kinase activity
K10K4_45340	COG0583	DNA-binding transcription factor activity
K10K4_45360	COG0531	amino acid
K10K4_45390	COG2205	protein histidine kinase activity
K10K4_45400	COG0745	RESPONSE REGULATOR receiver
K10K4_45460	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K10K4_45470	COG2239	Acts as a magnesium transporter
K10K4_45480	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K10K4_45490	COG0402	S-adenosylhomocysteine deaminase activity
K10K4_45500	COG1418	mRNA catabolic process
K10K4_45520	COG2814	Major facilitator Superfamily
K10K4_45540	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K10K4_45580	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K10K4_45610	COG0745	RESPONSE REGULATOR receiver
K10K4_45620	COG2205	protein histidine kinase activity
K10K4_45640	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K10K4_45650	COG2194	sulfuric ester hydrolase activity
K10K4_45690	COG4667	esterase of the alpha-beta hydrolase superfamily
K10K4_45700	COG1741	Belongs to the pirin family
K10K4_45710	COG1278	Cold shock
K10K4_45740	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K10K4_45750	COG0678	peroxiredoxin activity
K10K4_45750	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K10K4_45770	COG1686	Belongs to the peptidase S11 family
K10K4_45790	COG0625	glutathione transferase activity
K10K4_45800	COG1621	beta-fructofuranosidase activity
K10K4_45810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K10K4_45820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K10K4_45820	COG1263	PTS System
K10K4_45860	COG1028	Short-chain dehydrogenase reductase Sdr
K10K4_45890	COG3746	phosphate-selective porin O and P
K10K4_45920	COG0300	oxidoreductase activity
K10K4_45930	COG0583	DNA-binding transcription factor activity
K10K4_45940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K10K4_45940	COG2207	Transcriptional regulator
K10K4_45950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K10K4_45990	COG0513	Belongs to the DEAD box helicase family
K10K4_46010	COG0583	DNA-binding transcription factor activity
K10K4_46040	COG1902	pentaerythritol trinitrate reductase activity
K10K4_46050	COG1063	alcohol dehydrogenase
K10K4_46070	COG1028	Short-chain dehydrogenase reductase Sdr
K10K4_46090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K10K4_46100	COG0006	proline dipeptidase activity
K10K4_46110	COG3608	succinylglutamate desuccinylase aspartoacylase
K10K4_46120	COG1522	sequence-specific DNA binding
K10K4_46130	COG1012	belongs to the aldehyde dehydrogenase family
K10K4_46140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K10K4_46150	COG3122	Protein conserved in bacteria
K10K4_46180	COG0583	DNA-binding transcription factor activity
K10K4_46200	COG0252	asparaginase activity
K10K4_46210	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K10K4_46240	COG2197	response regulator
K10K4_46250	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K10K4_46260	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K10K4_46300	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K10K4_46360	COG3842	ATPase activity
K10K4_46400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K10K4_46460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K10K4_46470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K10K4_46530	COG0583	DNA-binding transcription factor activity
K10K4_46550	COG4948	Mandelate Racemase Muconate Lactonizing
K10K4_46560	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K10K4_46610	COG1342	Belongs to the UPF0251 family
K10K4_46620	COG4176	ABC-type proline glycine betaine transport system permease component
K10K4_46630	COG3448	diguanylate cyclase activity
K10K4_46630	COG4175	Glycine betaine
K10K4_46640	COG3015	lipoprotein NlpE involved in copper resistance
K10K4_46650	COG3713	MltA-interacting MipA family protein
K10K4_46680	COG0583	DNA-binding transcription factor activity
K10K4_46730	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K10K4_46750	COG1335	isochorismatase
K10K4_46780	COG1349	DNA-binding transcription factor activity
K10K4_46800	COG2070	2-Nitropropane dioxygenase
K10K4_46810	COG0531	amino acid
K10K4_46820	COG4302	ethanolamine ammonia-lyase activity
K10K4_46830	COG4303	Ethanolamine ammonia lyase large subunit
K10K4_46850	COG1309	transcriptional regulator
K10K4_46890	COG1280	lysine exporter protein (LysE YggA)
K10K4_46910	COG0459	protein refolding
K10K4_46920	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K10K4_46930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K10K4_46960	COG1304	FMN binding
K10K4_47010	COG1256	bacterial-type flagellum assembly
K10K4_47010	COG4786	Flagellar basal body rod
K10K4_47030	COG1706	bacterial-type flagellum-dependent cell motility
K10K4_47040	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K10K4_47050	COG4786	Flagellar basal body rod
K10K4_47060	COG4787	bacterial-type flagellum-dependent cell motility
K10K4_47070	COG1749	Flagellar hook protein flgE
K10K4_47080	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K10K4_47090	COG1558	bacterial-type flagellum-dependent cell motility
K10K4_47100	COG1815	bacterial-type flagellum-dependent cell motility
K10K4_47140	COG0741	lytic transglycosylase activity
K10K4_47150	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K10K4_47190	COG1760	l-serine dehydratase
K10K4_47220	COG0583	DNA-binding transcription factor activity
K10K4_47240	COG2866	Carboxypeptidase
K10K4_47250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K10K4_47270	COG2990	Protein conserved in bacteria
K10K4_47320	COG3842	ATPase activity
K10K4_47340	COG1840	ABC-type Fe3 transport system, periplasmic component
K10K4_47380	COG1609	Transcriptional regulator
K10K4_47440	COG3240	lipase activity
K10K4_47450	COG1309	transcriptional regulator
K10K4_47480	COG0577	efflux transmembrane transporter activity
K10K4_47480	COG1136	(ABC) transporter
K10K4_47490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K10K4_47500	COG2067	long-chain fatty acid transport protein
K10K4_47510	COG3338	carbonate dehydratase activity
K10K4_47520	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K10K4_47550	COG1011	Hydrolase
K10K4_47620	COG0110	maltose O-acetyltransferase activity
K10K4_47630	COG1765	OsmC-like protein
K10K4_47640	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K10K4_47640	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K10K4_47660	COG3046	protein related to deoxyribodipyrimidine photolyase
K10K4_47670	COG0415	Belongs to the DNA photolyase family
K10K4_47680	COG3706	GGDEF domain
K10K4_47710	COG3706	GGDEF domain
K10K4_47740	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K10K4_47770	COG3033	Beta-eliminating lyase
K10K4_47800	COG1271	oxidase subunit
K10K4_47810	COG1294	oxidase, subunit
K10K4_47840	COG3179	chitinase
K10K4_47850	COG0579	oxidoreductase
K10K4_47900	COG3706	GGDEF domain
K10K4_47960	COG0583	DNA-binding transcription factor activity
K10K4_48000	COG0189	ligase activity
K10K4_48010	COG0189	ligase activity
K10K4_48010	COG4067	protein conserved in archaea
K10K4_48030	COG1166	arginine decarboxylase activity
K10K4_48040	COG0010	Belongs to the arginase family
K10K4_48050	COG2814	Major facilitator Superfamily
K10K4_48060	COG1770	oligopeptidase
K10K4_48090	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K10K4_48100	COG1121	(ABC) transporter
K10K4_48110	COG0803	Belongs to the bacterial solute-binding protein 9 family
K10K4_48190	COG0848	biopolymer transport protein
K10K4_48200	COG0811	peptide transport
K10K4_48210	COG0811	peptide transport
K10K4_48250	COG0745	RESPONSE REGULATOR receiver
K10K4_48260	COG0584	glycerophosphoryl diester phosphodiesterase
K10K4_48280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K10K4_48410	COG0312	modulator of DNA gyrase
K10K4_48420	COG0312	modulator of DNA gyrase
K10K4_48430	COG0351	phosphomethylpyrimidine kinase
K10K4_48440	COG1116	anion transmembrane transporter activity
K10K4_48450	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K10K4_48460	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K10K4_48470	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K10K4_48510	COG0243	molybdopterin cofactor binding
K10K4_48520	COG3005	denitrification pathway
K10K4_48530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K10K4_48540	COG1028	Short-chain dehydrogenase reductase Sdr
K10K4_48570	COG0456	acetyltransferase
K10K4_48610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K10K4_48620	COG1929	Belongs to the glycerate kinase type-1 family
K10K4_48630	COG2610	gluconate transmembrane transporter activity
K10K4_48640	COG3835	regulator
K10K4_48770	COG3047	cAMP biosynthetic process
K10K4_48790	COG1357	PFAM Pentapeptide repeats (8 copies)
K10K4_48850	COG2375	cellular response to nickel ion
K10K4_48860	COG0583	DNA-binding transcription factor activity
K10K4_48870	COG2162	N-hydroxyarylamine O-acetyltransferase activity
K10K4_48880	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K10K4_48930	COG2199	diguanylate cyclase activity
K10K4_48950	COG0561	phosphatase activity
K10K4_48960	COG0583	DNA-binding transcription factor activity
K10K4_48990	COG0564	pseudouridine synthase activity
K10K4_49000	COG0534	Mate efflux family protein
K10K4_49010	COG5001	Diguanylate cyclase
K10K4_49030	COG3123	guanosine phosphorylase activity
K10K4_49060	COG0596	Alpha beta hydrolase
K10K4_49120	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K10K4_49140	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K10K4_49150	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K10K4_49150	COG2169	Transcriptional regulator
K10K4_49170	COG2259	Doxx family
K10K4_49180	COG1741	Belongs to the pirin family
K10K4_49220	COG0363	glucosamine-6-phosphate deaminase activity
K10K4_49240	COG0786	glutamate:sodium symporter activity
K10K4_49250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K10K4_49260	COG1131	(ABC) transporter
K10K4_49280	COG0786	glutamate:sodium symporter activity
K10K4_49320	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K10K4_49340	COG3279	Response regulator of the LytR AlgR family
K10K4_49350	COG3275	phosphorelay sensor kinase activity
K10K4_49410	COG0772	Belongs to the SEDS family
K10K4_49460	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
K10K4_49460	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K10K4_49480	COG0444	Belongs to the ABC transporter superfamily
K10K4_49490	COG4608	Belongs to the ABC transporter superfamily