locus-tag	class	description
LN249_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LN249_00010	COG0592	DNA-directed DNA polymerase activity
LN249_00020	COG0187	DNA topoisomerase II activity
LN249_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
LN249_00035	COG3977	Valine--pyruvate aminotransferase
LN249_00040	COG0366	Alpha amylase catalytic
LN249_00045	COG0751	glycine-tRNA ligase activity
LN249_00055	COG2119	membrane
LN249_00065	COG0425	Belongs to the sulfur carrier protein TusA family
LN249_00080	COG0604	alcohol dehydrogenase
LN249_00085	COG0183	Belongs to the thiolase family
LN249_00095	COG1739	Uncharacterized protein family UPF0029
LN249_00100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LN249_00140	COG0583	DNA-binding transcription factor activity
LN249_00145	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LN249_00150	COG2960	long-chain fatty acid transporting porin activity
LN249_00155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LN249_00160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LN249_00215	COG4166	transmembrane transport
LN249_00220	COG0601	transmembrane transport
LN249_00225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LN249_00265	COG1609	Transcriptional regulator
LN249_00270	COG0583	DNA-binding transcription factor activity
LN249_00285	COG0129	dihydroxy-acid dehydratase activity
LN249_00290	COG3265	gluconokinase activity
LN249_00295	COG2610	gluconate transmembrane transporter activity
LN249_00300	COG0800	Aldolase
LN249_00305	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LN249_00310	COG0583	DNA-binding transcription factor activity
LN249_00315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LN249_00320	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LN249_00330	COG1522	sequence-specific DNA binding
LN249_00335	COG5002	protein histidine kinase activity
LN249_00335	COG5001	Diguanylate cyclase
LN249_00340	COG0742	ribosomal rna small subunit methyltransferase
LN249_00355	COG0589	response to stress
LN249_00360	COG1528	Iron-storage protein
LN249_00370	COG2081	HI0933 family
LN249_00410	COG1278	Cold shock
LN249_00430	COG0330	HflC and HflK could
LN249_00495	COG1597	lipid kinase activity
LN249_00525	COG0628	permease
LN249_00540	COG1322	Protein conserved in bacteria
LN249_00545	COG2226	methyltransferase
LN249_00550	COG3165	ubiquinone biosynthetic process from chorismate
LN249_00555	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LN249_00565	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LN249_00570	COG0805	protein transport
LN249_00575	COG0084	hydrolase, TatD family'
LN249_00585	COG0456	acetyltransferase
LN249_00590	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LN249_00590	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LN249_00595	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LN249_00625	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LN249_00635	COG2204	response regulator
LN249_00640	COG3852	Histidine kinase
LN249_00650	COG0174	glutamine synthetase
LN249_00655	COG1217	gtp-binding protein TYPA
LN249_00670	COG1295	ribonuclease BN
LN249_00675	COG1490	D-aminoacyl-tRNA deacylase activity
LN249_00680	COG0456	acetyltransferase
LN249_00690	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LN249_00695	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LN249_00700	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LN249_00705	COG3031	protein transport across the cell outer membrane
LN249_00715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LN249_00720	COG1459	type II secretion system
LN249_00725	COG2165	general secretion pathway protein
LN249_00730	COG2165	general secretion pathway protein
LN249_00735	COG2165	general secretion pathway protein
LN249_00740	COG4795	General secretion pathway protein
LN249_00745	COG3156	type II secretion system protein K
LN249_00750	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
LN249_00755	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
LN249_00765	COG1218	3'(2'),5'-bisphosphate nucleotidase
LN249_00770	COG0494	nUDIX hydrolase
LN249_00775	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LN249_00775	COG0316	Belongs to the HesB IscA family
LN249_00780	COG1040	competence protein
LN249_00785	COG0596	Alpha beta hydrolase
LN249_00795	COG2183	response to ionizing radiation
LN249_00805	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LN249_00825	COG2233	PERMEase
LN249_00830	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LN249_00835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LN249_00840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LN249_00850	COG0194	GDP metabolic process
LN249_00865	COG0848	biopolymer transport protein
LN249_00870	COG0811	peptide transport
LN249_00885	COG4206	TonB-dependent receptor
LN249_00890	COG4174	ABC transporter (Permease)
LN249_00895	COG4239	(ABC) transporter, permease
LN249_00900	COG0747	negative chemotaxis
LN249_00910	COG4608	Belongs to the ABC transporter superfamily
LN249_00920	COG1561	YicC-like family, N-terminal region
LN249_00925	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LN249_00930	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LN249_00935	COG1560	Kdo2-lipid A biosynthetic process
LN249_00940	COG1309	transcriptional regulator
LN249_00945	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LN249_00955	COG2003	Belongs to the UPF0758 family
LN249_00980	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LN249_00995	COG0463	Glycosyl transferase, family 2
LN249_01000	COG0859	PFAM glycosyl transferase family 9
LN249_01005	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LN249_01010	COG3642	lipopolysaccharide core region biosynthetic process
LN249_01020	COG1216	Glycosyl transferase, family 2
LN249_01020	COG1442	glycosyl transferase family 8
LN249_01030	COG1519	Transferase
LN249_01035	COG0859	PFAM glycosyl transferase family 9
LN249_01040	COG1560	Kdo2-lipid A biosynthetic process
LN249_01050	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LN249_01085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LN249_01095	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LN249_01115	COG0110	maltose O-acetyltransferase activity
LN249_01135	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LN249_01170	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LN249_01180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LN249_01185	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LN249_01190	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LN249_01200	COG1045	serine acetyltransferase
LN249_01225	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
LN249_01250	COG0149	triose-phosphate isomerase activity
LN249_01280	COG1494	fructose-1,6-bisphosphatase
LN249_01290	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LN249_01295	COG1575	Belongs to the MenA family. Type 1 subfamily
LN249_01300	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LN249_01305	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LN249_01315	COG1609	Transcriptional regulator
LN249_01320	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LN249_01325	COG0254	rRNA binding
LN249_01335	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LN249_01340	COG0088	Forms part of the polypeptide exit tunnel
LN249_01350	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LN249_01355	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LN249_01360	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LN249_01365	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LN249_01375	COG0255	Belongs to the universal ribosomal protein uL29 family
LN249_01380	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LN249_01390	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LN249_01395	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LN249_01400	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LN249_01405	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LN249_01410	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LN249_01425	COG1841	ribosomal large subunit assembly
LN249_01430	COG0200	Binds to the 23S rRNA
LN249_01435	COG0201	protein transport
LN249_01440	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LN249_01445	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LN249_01450	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LN249_01460	COG0202	RNA polymerase activity
LN249_01465	COG0203	ribosomal protein L17
LN249_01475	COG0545	Peptidyl-prolyl cis-trans isomerase
LN249_01485	COG2153	protein acetylation
LN249_01490	COG0513	Belongs to the DEAD box helicase family
LN249_01500	COG0737	Belongs to the 5'-nucleotidase family
LN249_01505	COG1648	precorrin-2 dehydrogenase activity
LN249_01505	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LN249_01515	COG2895	sulfate adenylyltransferase (ATP) activity
LN249_01520	COG0471	metal ion transport
LN249_01520	COG3273	potassium ion transport
LN249_01525	COG0529	Catalyzes the synthesis of activated sulfate
LN249_01545	COG4181	ATPase activity
LN249_01560	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
LN249_01570	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LN249_01575	COG0729	surface antigen
LN249_01580	COG2911	Protein conserved in bacteria
LN249_01585	COG2105	PFAM AIG2 family protein
LN249_01595	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LN249_01600	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LN249_01605	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LN249_01610	COG0163	prenyltransferase activity
LN249_01615	COG4143	(ABC) transporter
LN249_01620	COG1178	ABC-type Fe3 transport system permease component
LN249_01625	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
LN249_01630	COG0583	DNA-binding transcription factor activity
LN249_01635	COG1902	pentaerythritol trinitrate reductase activity
LN249_01650	COG2358	TRAP transporter, solute receptor (TAXI family
LN249_01670	COG0142	geranyltranstransferase activity
LN249_01675	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LN249_01685	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LN249_01690	COG2966	Psort location CytoplasmicMembrane, score
LN249_01710	COG2967	ApaG domain
LN249_01715	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LN249_01720	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LN249_01725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LN249_01730	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LN249_01735	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LN249_01755	COG0473	3-isopropylmalate dehydrogenase activity
LN249_01760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LN249_01780	COG0583	DNA-binding transcription factor activity
LN249_01785	COG1022	Amp-dependent synthetase and ligase
LN249_01790	COG0028	Belongs to the TPP enzyme family
LN249_01810	COG0469	pyruvate kinase activity
LN249_01815	COG1349	DNA-binding transcription factor activity
LN249_01820	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LN249_01835	COG5002	protein histidine kinase activity
LN249_01845	COG2376	Dihydroxyacetone kinase
LN249_01850	COG1461	Dihydroxyacetone kinase
LN249_01865	COG3722	fumarate hydratase activity
LN249_01875	COG2213	PTS system mannitol-specific
LN249_01875	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LN249_01920	COG0358	DNA primase activity
LN249_01925	COG1610	YqeY-like protein
LN249_01930	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LN249_01935	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LN249_01940	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LN249_01945	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LN249_01950	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LN249_01955	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LN249_01960	COG1968	undecaprenyl-diphosphatase activity
LN249_01980	COG0405	Gamma-glutamyltransferase
LN249_01985	COG4991	sh3 domain protein
LN249_01990	COG0306	phosphate transporter
LN249_01995	COG1392	Phosphate transport regulator
LN249_02000	COG3025	triphosphatase activity
LN249_02015	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LN249_02020	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LN249_02020	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LN249_02025	COG1538	Outer membrane efflux protein
LN249_02030	COG0494	nUDIX hydrolase
LN249_02035	COG3151	Protein conserved in bacteria
LN249_02045	COG3150	esterase
LN249_02055	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LN249_02060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LN249_02070	COG3105	Protein conserved in bacteria
LN249_02075	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LN249_02080	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LN249_02085	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LN249_02090	COG0723	plastoquinol--plastocyanin reductase activity
LN249_02095	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LN249_02100	COG2857	Cytochrome c1
LN249_02105	COG0625	glutathione transferase activity
LN249_02110	COG2969	positive regulation of protein catabolic process
LN249_02115	COG2823	Periplasmic or secreted lipoprotein
LN249_02120	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LN249_02135	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LN249_02150	COG3116	cell division
LN249_02155	COG0768	penicillin binding
LN249_02160	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LN249_02165	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LN249_02170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LN249_02175	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LN249_02190	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LN249_02195	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LN249_02200	COG0849	cell division
LN249_02205	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LN249_02210	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LN249_02220	COG0653	protein targeting
LN249_02225	COG0494	nUDIX hydrolase
LN249_02235	COG0505	Belongs to the CarA family
LN249_02240	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LN249_02255	COG0730	response to heat
LN249_02270	COG0583	DNA-binding transcription factor activity
LN249_02275	COG2860	membrane
LN249_02290	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LN249_02300	COG0493	'glutamate synthase
LN249_02305	COG0067	glutamate synthase
LN249_02305	COG0069	glutamate synthase activity
LN249_02305	COG0070	glutamate synthase
LN249_02315	COG0067	glutamate synthase
LN249_02315	COG0069	glutamate synthase activity
LN249_02315	COG0070	glutamate synthase
LN249_02320	COG1242	4 iron, 4 sulfur cluster binding
LN249_02325	COG5001	Diguanylate cyclase
LN249_02325	COG4251	negative regulation of phosphorylation
LN249_02325	COG3706	GGDEF domain
LN249_02325	COG2203	Gaf domain
LN249_02330	COG5002	protein histidine kinase activity
LN249_02330	COG2198	Histidine kinase
LN249_02330	COG0784	Response regulator, receiver
LN249_02340	COG0745	RESPONSE REGULATOR receiver
LN249_02350	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LN249_02370	COG0083	homoserine kinase activity
LN249_02375	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LN249_02385	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
LN249_02390	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LN249_02395	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LN249_02410	COG1115	amino acid carrier protein
LN249_02415	COG3022	response to hydroperoxide
LN249_02420	COG0513	Belongs to the DEAD box helicase family
LN249_02425	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LN249_02435	COG0716	FMN binding
LN249_02440	COG4974	Belongs to the 'phage' integrase family
LN249_02445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LN249_02450	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LN249_02460	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LN249_02465	COG2204	response regulator
LN249_02475	COG0667	Aldo Keto reductase
LN249_02500	COG0730	response to heat
LN249_02505	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LN249_02510	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LN249_02520	COG1283	sodium-dependent phosphate transmembrane transporter activity
LN249_02525	COG0583	DNA-binding transcription factor activity
LN249_02530	COG0640	Transcriptional regulator
LN249_02535	COG0268	Binds directly to 16S ribosomal RNA
LN249_02540	COG0728	peptidoglycan biosynthetic process
LN249_02545	COG0196	riboflavin kinase activity
LN249_02555	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LN249_02560	COG1047	Peptidyl-prolyl cis-trans
LN249_02565	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LN249_02575	COG3279	Response regulator of the LytR AlgR family
LN249_02580	COG3275	phosphorelay sensor kinase activity
LN249_02585	COG1966	Carbon starvation protein
LN249_02605	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LN249_02610	COG1472	Belongs to the glycosyl hydrolase 3 family
LN249_02615	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LN249_02620	COG0287	Prephenate dehydrogenase
LN249_02620	COG1605	Chorismate mutase
LN249_02625	COG0739	heme binding
LN249_02625	COG0741	lytic transglycosylase activity
LN249_02625	COG1196	nuclear chromosome segregation
LN249_02635	COG0488	(ABC) transporter
LN249_02645	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
LN249_02650	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
LN249_02655	COG1605	Chorismate mutase
LN249_02655	COG0077	Prephenate dehydratase
LN249_02660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LN249_02665	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LN249_02670	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LN249_02675	COG0564	pseudouridine synthase activity
LN249_02685	COG0542	response to heat
LN249_02740	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LN249_02745	COG0826	peptidase U32
LN249_02750	COG2974	May be involved in recombination
LN249_02755	COG0745	RESPONSE REGULATOR receiver
LN249_02760	COG5002	protein histidine kinase activity
LN249_02770	COG0248	Ppx GppA phosphatase
LN249_02775	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LN249_02780	COG0573	inorganic phosphate transmembrane transporter activity
LN249_02785	COG0581	inorganic phosphate transmembrane transporter activity
LN249_02790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LN249_02795	COG0704	Plays a role in the regulation of phosphate uptake
LN249_02805	COG3142	Participates in the control of copper homeostasis
LN249_02810	COG0450	alkyl hydroperoxide reductase
LN249_02815	COG0583	DNA-binding transcription factor activity
LN249_02820	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LN249_02830	COG0517	IMP dehydrogenase activity
LN249_02840	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LN249_02850	COG1862	Preprotein translocase
LN249_02855	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LN249_02860	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LN249_02865	COG0483	inositol monophosphate 1-phosphatase activity
LN249_02870	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LN249_02880	COG1104	cysteine desulfurase activity
LN249_02885	COG0822	iron-sulfur transferase activity
LN249_02900	COG0443	Heat shock 70 kDa protein
LN249_02905	COG0633	Ferredoxin
LN249_02910	COG2975	iron-sulfur cluster assembly
LN249_02920	COG0105	UTP biosynthetic process
LN249_02935	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LN249_02940	COG0124	histidyl-tRNA synthetase
LN249_02945	COG2976	Protein conserved in bacteria
LN249_02950	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LN249_02955	COG1160	GTP binding
LN249_02975	COG0516	GMP reductase activity
LN249_02975	COG0517	IMP dehydrogenase activity
LN249_02980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LN249_02980	COG0519	Catalyzes the synthesis of GMP from XMP
LN249_02985	COG1757	Na H antiporter
LN249_02995	COG1584	GPR1 FUN34 yaaH family protein
LN249_03000	COG1115	amino acid carrier protein
LN249_03020	COG2873	o-acetylhomoserine
LN249_03025	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LN249_03045	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LN249_03045	COG3153	acetyltransferase
LN249_03050	COG0583	DNA-binding transcription factor activity
LN249_03060	COG1396	sequence-specific DNA binding
LN249_03090	COG3300	MHYT domain
LN249_03090	COG5001	Diguanylate cyclase
LN249_03145	COG0270	DNA (cytosine-5-)-methyltransferase activity
LN249_03160	COG0582	viral genome integration into host DNA
LN249_03170	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LN249_03175	COG2867	negative regulation of translational initiation
LN249_03180	COG2914	Belongs to the UPF0125 (RnfH) family
LN249_03185	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LN249_03190	COG0497	DNA recombination
LN249_03200	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LN249_03205	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LN249_03210	COG1301	dicarboxylic acid transport
LN249_03220	COG0484	heat shock protein binding
LN249_03230	COG4969	Belongs to the N-Me-Phe pilin family
LN249_03250	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LN249_03260	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LN249_03265	COG0047	phosphoribosylformylglycinamidine synthase activity
LN249_03265	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LN249_03280	COG1629	transport
LN249_03295	COG2195	Cleaves the N-terminal amino acid of tripeptides
LN249_03300	COG2252	PERMEase
LN249_03305	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LN249_03310	COG1073	alpha beta
LN249_03320	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LN249_03325	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LN249_03330	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LN249_03335	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LN249_03335	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LN249_03350	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LN249_03360	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LN249_03365	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LN249_03370	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LN249_03375	COG0142	geranyltranstransferase activity
LN249_03380	COG1722	exodeoxyribonuclease VII activity
LN249_03385	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LN249_03395	COG0301	tRNA thio-modification
LN249_03395	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LN249_03400	COG0583	DNA-binding transcription factor activity
LN249_03410	COG2363	Small membrane protein
LN249_03420	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LN249_03425	COG1611	Belongs to the LOG family
LN249_03440	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LN249_03440	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LN249_03450	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
LN249_03455	COG1464	Belongs to the NlpA lipoprotein family
LN249_03460	COG2011	ABC-type metal ion transport system permease component
LN249_03465	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LN249_03470	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LN249_03480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LN249_03480	COG1263	PTS System
LN249_03485	COG0366	Alpha amylase catalytic
LN249_03500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LN249_03505	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LN249_03510	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LN249_03515	COG0321	lipoyl(octanoyl) transferase activity
LN249_03525	COG1686	Belongs to the peptidase S11 family
LN249_03530	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LN249_03535	COG0772	Belongs to the SEDS family
LN249_03540	COG0768	penicillin binding
LN249_03545	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LN249_03550	COG0799	negative regulation of ribosome biogenesis
LN249_03555	COG1466	dna polymerase III delta subunit
LN249_03560	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
LN249_03565	COG0495	leucyl-tRNA aminoacylation
LN249_03570	COG2888	peptidyl-tyrosine sulfation
LN249_03575	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LN249_03580	COG4535	Mg2 and Co2 transporter CorC
LN249_03585	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LN249_03590	COG1702	phosphate starvation-inducible protein PhoH
LN249_03595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LN249_03600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LN249_03705	COG0012	GTP binding
LN249_03710	COG0193	aminoacyl-tRNA hydrolase activity
LN249_03715	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LN249_03725	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LN249_03730	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LN249_03740	COG2890	protein-(glutamine-N5) methyltransferase activity
LN249_03745	COG3094	Invasion gene expression up-regulator, SirB
LN249_03750	COG2912	Transglutaminase-like superfamily
LN249_03755	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LN249_03760	COG0737	Belongs to the 5'-nucleotidase family
LN249_03770	COG1187	pseudouridine synthase activity
LN249_03775	COG2840	Smr protein MutS2
LN249_03815	COG2217	Heavy metal translocating P-type atpase
LN249_03815	COG2608	mercury ion transmembrane transporter activity
LN249_03825	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
LN249_03880	COG0784	Response regulator, receiver
LN249_03880	COG0835	chemotaxis
LN249_03885	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LN249_03890	COG1815	bacterial-type flagellum-dependent cell motility
LN249_03895	COG1558	bacterial-type flagellum-dependent cell motility
LN249_03905	COG1749	Flagellar hook protein flgE
LN249_03910	COG4787	bacterial-type flagellum-dependent cell motility
LN249_03920	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LN249_03925	COG1706	bacterial-type flagellum-dependent cell motility
LN249_03930	COG1705	Flagellar rod assembly protein muramidase FlgJ
LN249_03930	COG3951	Flagellar rod assembly protein muramidase FlgJ
LN249_03940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LN249_03945	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LN249_03950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LN249_03955	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LN249_03960	COG2190	(PTS) system
LN249_03965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LN249_03970	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LN249_03975	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LN249_03980	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
LN249_03985	COG3115	cell septum assembly
LN249_03990	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LN249_04010	COG0330	HflC and HflK could
LN249_04015	COG3118	belongs to the thioredoxin family
LN249_04020	COG0300	oxidoreductase activity
LN249_04025	COG1090	epimerase
LN249_04055	COG0622	Phosphoesterase
LN249_04075	COG3710	Transcriptional regulator
LN249_04080	COG0326	Molecular chaperone. Has ATPase activity
LN249_04090	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LN249_04095	COG3104	oligopeptide transport
LN249_04100	COG0250	Participates in transcription elongation, termination and antitermination
LN249_04105	COG0367	asparagine synthase
LN249_04110	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LN249_04110	COG4651	solute:proton antiporter activity
LN249_04115	COG1846	Transcriptional regulator
LN249_04115	COG1940	carbohydrate kinase activity
LN249_04120	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LN249_04125	COG1263	PTS System
LN249_04125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LN249_04125	COG2190	(PTS) system
LN249_04130	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LN249_04135	COG0735	belongs to the Fur family
LN249_04145	COG0716	FMN binding
LN249_04155	COG0596	Alpha beta hydrolase
LN249_04160	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
LN249_04165	COG0033	Phosphoglucomutase
LN249_04175	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LN249_04190	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LN249_04195	COG1053	succinate dehydrogenase
LN249_04200	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LN249_04205	COG0567	Dehydrogenase, E1 component
LN249_04210	COG0508	dehydrogenase complex catalyzes the overall conversion of
LN249_04225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LN249_04230	COG1121	(ABC) transporter
LN249_04235	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
LN249_04240	COG4977	sequence-specific DNA binding
LN249_04245	COG1918	ferrous iron import across plasma membrane
LN249_04265	COG0018	arginyl-trna synthetase
LN249_04285	COG0788	formyltetrahydrofolate deformylase activity
LN249_04290	COG1199	ATP-dependent helicase activity
LN249_04295	COG1214	PFAM Peptidase M22, glycoprotease
LN249_04305	COG3065	identical protein binding
LN249_04310	COG2267	carboxylic ester hydrolase activity
LN249_04315	COG0318	PFAM AMP-dependent synthetase and ligase
LN249_04320	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LN249_04325	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LN249_04330	COG2894	cell division
LN249_04335	COG0850	regulation of cytokinetic process
LN249_04340	COG3100	YcgL domain-containing protein
LN249_04345	COG2951	lytic endotransglycosylase activity
LN249_04355	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LN249_04360	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LN249_04420	COG1028	Short-chain dehydrogenase reductase Sdr
LN249_04430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LN249_04455	COG2986	histidine ammonia-lyase
LN249_04460	COG1216	Glycosyl transferase, family 2
LN249_04465	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LN249_04480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LN249_04485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LN249_04520	COG1253	flavin adenine dinucleotide binding
LN249_04525	COG0513	Belongs to the DEAD box helicase family
LN249_04530	COG0569	domain protein
LN249_04535	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LN249_04550	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LN249_04555	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LN249_04560	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LN249_04565	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LN249_04590	COG0544	peptidyl-prolyl cis-trans isomerase activity
LN249_04600	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LN249_04605	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LN249_04610	COG0776	regulation of translation
LN249_04615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LN249_04620	COG1555	photosystem II stabilization
LN249_04635	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LN249_04640	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LN249_04645	COG0436	Aminotransferase
LN249_04650	COG1169	isochorismate synthase
LN249_04655	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LN249_04660	COG0596	Alpha beta hydrolase
LN249_04665	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LN249_04685	COG2855	membrane
LN249_04690	COG0477	Major facilitator Superfamily
LN249_04735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LN249_04740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LN249_04760	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LN249_04765	COG1522	sequence-specific DNA binding
LN249_04775	COG1946	Acyl-CoA thioesterase
LN249_04780	COG3126	Type III secretion system lipoprotein chaperone (YscW)
LN249_04805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LN249_04835	COG0537	adenosine 5'-monophosphoramidase activity
LN249_04860	COG3150	esterase
LN249_04865	COG1252	NADH dehydrogenase
LN249_04880	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LN249_04890	COG4591	ABC-type transport system involved in lipoprotein release permease component
LN249_04895	COG1136	(ABC) transporter
LN249_04900	COG4591	ABC-type transport system involved in lipoprotein release permease component
LN249_04910	COG0658	competence protein
LN249_04910	COG2333	competence protein COMEC
LN249_04915	COG1132	(ABC) transporter
LN249_04935	COG2719	SpoVR family
LN249_04940	COG2718	Belongs to the UPF0229 family
LN249_04945	COG2766	serine protein kinase
LN249_04950	COG3013	Belongs to the UPF0304 family
LN249_04960	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LN249_04970	COG1882	Formate acetyltransferase
LN249_05010	COG0708	Exodeoxyribonuclease III
LN249_05020	COG3923	Primosomal replication protein n
LN249_05025	COG0730	response to heat
LN249_05030	COG1199	ATP-dependent helicase activity
LN249_05035	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LN249_05040	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
LN249_05045	COG1187	pseudouridine synthase activity
LN249_05055	COG1278	Cold shock
LN249_05060	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LN249_05065	COG0542	response to heat
LN249_05070	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LN249_05075	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LN249_05080	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LN249_05100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LN249_05105	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LN249_05110	COG0297	glycogen (starch) synthase activity
LN249_05130	COG3070	regulator of competence-specific genes
LN249_05135	COG1609	Transcriptional regulator
LN249_05140	COG3381	protein complex oligomerization
LN249_05145	COG0745	RESPONSE REGULATOR receiver
LN249_05150	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LN249_05155	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LN249_05160	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
LN249_05165	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
LN249_05170	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LN249_05190	COG0189	ligase activity
LN249_05190	COG4067	protein conserved in archaea
LN249_05195	COG0500	methyltransferase
LN249_05200	COG4106	trans-aconitate 2-methyltransferase activity
LN249_05205	COG1801	Protein of unknown function DUF72
LN249_05215	COG0217	transcriptional regulatory protein
LN249_05220	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LN249_05225	COG0632	four-way junction helicase activity
LN249_05230	COG2255	four-way junction helicase activity
LN249_05235	COG1271	oxidase subunit
LN249_05240	COG1294	oxidase, subunit
LN249_05245	COG4890	Cyd operon protein YbgT
LN249_05255	COG0824	Thioesterase
LN249_05260	COG0811	peptide transport
LN249_05275	COG0823	Involved in the tonB-independent uptake of proteins
LN249_05280	COG2885	chlorophyll binding
LN249_05285	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
LN249_05290	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LN249_05300	COG3766	membrane
LN249_05310	COG0754	glutathionylspermidine amidase activity
LN249_05320	COG5002	protein histidine kinase activity
LN249_05320	COG0784	Response regulator, receiver
LN249_05360	COG0840	transmembrane signaling receptor activity
LN249_05365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LN249_05370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LN249_05395	COG3568	Endonuclease Exonuclease Phosphatase
LN249_05405	COG0840	transmembrane signaling receptor activity
LN249_05420	COG0583	DNA-binding transcription factor activity
LN249_05430	COG0686	Belongs to the AlaDH PNT family
LN249_05445	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LN249_05450	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LN249_05455	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LN249_05490	COG1073	alpha beta
LN249_05490	COG2226	methyltransferase
LN249_05495	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LN249_05515	COG0300	oxidoreductase activity
LN249_05530	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LN249_05540	COG2268	Band 7 protein
LN249_05550	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LN249_05555	COG2915	High frequency lysogenization protein hflD homolog
LN249_05560	COG0482	sulfurtransferase activity
LN249_05570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LN249_05580	COG1757	Na H antiporter
LN249_05590	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LN249_05595	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LN249_05600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LN249_05605	COG0131	Imidazoleglycerol-phosphate dehydratase
LN249_05605	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LN249_05610	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LN249_05615	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LN249_05625	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LN249_05625	COG0140	phosphoribosyl-ATP diphosphatase activity
LN249_05630	COG3012	SEC-C Motif Domain Protein
LN249_05635	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LN249_05640	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LN249_05645	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LN249_05650	COG0215	cysteine-tRNA ligase activity
LN249_05655	COG1435	thymidine kinase activity
LN249_05660	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LN249_05685	COG2116	formate transmembrane transporter activity
LN249_05695	COG0390	transport system, permease component
LN249_05700	COG4459	periplasmic nitrate reductase
LN249_05705	COG3005	denitrification pathway
LN249_05710	COG0243	molybdopterin cofactor binding
LN249_05725	COG1227	inorganic diphosphatase activity
LN249_05735	COG4172	Belongs to the ABC transporter superfamily
LN249_05745	COG4171	peptide transport system, permease
LN249_05760	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
LN249_05765	COG1842	Phage shock protein A
LN249_05775	COG1983	PspC domain protein
LN249_05795	COG2818	Glycosylase
LN249_05800	COG5380	lipid catabolic process
LN249_05805	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LN249_05810	COG0626	cystathionine gamma-synthase activity
LN249_05820	COG0733	neurotransmitter:sodium symporter activity
LN249_05825	COG0564	pseudouridine synthase activity
LN249_05835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LN249_05840	COG1151	hydroxylamine reductase activity
LN249_05845	COG3604	Transcriptional regulator
LN249_05855	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LN249_05860	COG4136	ATPase activity
LN249_05865	COG4135	transport system, permease component
LN249_05870	COG4134	Bacterial extracellular solute-binding protein
LN249_05880	COG3313	Fe-S protein
LN249_05900	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LN249_05920	COG1061	Type III restriction enzyme res subunit
LN249_05925	COG1187	pseudouridine synthase activity
LN249_05930	COG2814	Major facilitator Superfamily
LN249_05965	COG3005	denitrification pathway
LN249_05970	COG0702	epimerase
LN249_05975	COG0534	Mate efflux family protein
LN249_05980	COG1136	(ABC) transporter
LN249_05995	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LN249_06005	COG1960	acyl-CoA dehydrogenase activity
LN249_06010	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LN249_06015	COG2985	domain, Protein
LN249_06015	COG3273	potassium ion transport
LN249_06020	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LN249_06030	COG1737	Transcriptional regulator
LN249_06035	COG0076	glutamate decarboxylase activity
LN249_06045	COG2431	L-lysine efflux transmembrane transporter activity
LN249_06055	COG3070	regulator of competence-specific genes
LN249_06070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LN249_06070	COG4191	Histidine kinase
LN249_06080	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LN249_06090	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LN249_06095	COG4988	ABC transporter
LN249_06100	COG0492	ferredoxin-NADP+ reductase activity
LN249_06125	COG0471	metal ion transport
LN249_06130	COG2949	membrane
LN249_06140	COG1643	Atp-dependent helicase
LN249_06155	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LN249_06190	COG0247	lactate metabolic process
LN249_06190	COG0277	FAD linked oxidase domain protein
LN249_06205	COG2986	histidine ammonia-lyase
LN249_06210	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LN249_06215	COG0010	Belongs to the arginase family
LN249_06220	COG1228	amidohydrolase
LN249_06225	COG2188	Transcriptional regulator
LN249_06240	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LN249_06250	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LN249_06260	COG0393	Putative heavy-metal-binding
LN249_06290	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LN249_06295	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LN249_06295	COG0072	phenylalanine-tRNA ligase activity
LN249_06305	COG0776	regulation of translation
LN249_06315	COG0500	methyltransferase
LN249_06320	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LN249_06325	COG0295	cytidine deaminase activity
LN249_06330	COG1346	cytolysis
LN249_06335	COG1380	Effector of murein hydrolase LrgA
LN249_06340	COG2925	Exonuclease
LN249_06345	COG1823	symporter activity
LN249_06350	COG0702	epimerase
LN249_06355	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LN249_06360	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
LN249_06380	COG2988	succinylglutamate desuccinylase activity
LN249_06385	COG4139	cobalamin transport
LN249_06390	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
LN249_06410	COG0583	DNA-binding transcription factor activity
LN249_06420	COG1451	nucleotide metabolic process
LN249_06425	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
LN249_06455	COG3938	Belongs to the proline racemase family
LN249_06470	COG2423	ornithine cyclodeaminase activity
LN249_06475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LN249_06480	COG3842	ATPase activity
LN249_06485	COG1176	ABC-type spermidine putrescine transport system, permease component I
LN249_06490	COG1177	transmembrane transport
LN249_06505	COG3291	Pkd domain containing protein
LN249_06520	COG0444	Belongs to the ABC transporter superfamily
LN249_06525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LN249_06530	COG0601	transmembrane transport
LN249_06540	COG2195	Cleaves the N-terminal amino acid of tripeptides
LN249_06550	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LN249_06560	COG0625	glutathione transferase activity
LN249_06595	COG2200	EAL domain
LN249_06605	COG1846	Transcriptional regulator
LN249_06610	COG2315	Protein conserved in bacteria
LN249_06625	COG0110	maltose O-acetyltransferase activity
LN249_06655	COG3063	Type IV pilus biogenesis stability protein PilW
LN249_06660	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LN249_06675	COG0531	amino acid
LN249_06680	COG1560	Kdo2-lipid A biosynthetic process
LN249_06685	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LN249_06690	COG1280	lysine exporter protein (LysE YggA)
LN249_06700	COG1115	amino acid carrier protein
LN249_06725	COG1368	sulfuric ester hydrolase activity
LN249_06730	COG0642	Histidine kinase
LN249_06735	COG0745	RESPONSE REGULATOR receiver
LN249_06745	COG1028	Short-chain dehydrogenase reductase Sdr
LN249_06765	COG2113	Glycine betaine
LN249_06770	COG4176	ABC-type proline glycine betaine transport system permease component
LN249_06795	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LN249_06800	COG0456	acetyltransferase
LN249_06805	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LN249_06810	COG0662	Cupin 2, conserved barrel domain protein
LN249_06815	COG0527	aspartate kinase activity
LN249_06820	COG3119	arylsulfatase activity
LN249_06835	COG0641	radical SAM
LN249_06850	COG1349	DNA-binding transcription factor activity
LN249_06855	COG0673	inositol 2-dehydrogenase activity
LN249_06860	COG4702	Belongs to the UPF0303 family
LN249_06885	COG0471	metal ion transport
LN249_06890	COG4191	Histidine kinase
LN249_06900	COG3300	MHYT domain
LN249_06900	COG5001	Diguanylate cyclase
LN249_06915	COG1328	CTP reductase activity
LN249_06920	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LN249_06930	COG0861	Integral membrane protein TerC family
LN249_06940	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LN249_06950	COG0814	amino acid
LN249_06965	COG1120	ATPase activity
LN249_06970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LN249_06980	COG4774	siderophore transport
LN249_06990	COG1132	(ABC) transporter
LN249_06995	COG1132	(ABC) transporter
LN249_07000	COG2165	general secretion pathway protein
LN249_07020	COG0443	Heat shock 70 kDa protein
LN249_07070	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LN249_07075	COG1643	Atp-dependent helicase
LN249_07090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LN249_07100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LN249_07105	COG1215	transferase activity, transferring glycosyl groups
LN249_07110	COG0438	transferase activity, transferring glycosyl groups
LN249_07140	COG0438	transferase activity, transferring glycosyl groups
LN249_07150	COG2204	response regulator
LN249_07180	COG1793	dna ligase
LN249_07190	COG0534	Mate efflux family protein
LN249_07195	COG0307	riboflavin synthase, alpha
LN249_07205	COG3001	Fructosamine kinase
LN249_07215	COG3706	GGDEF domain
LN249_07225	COG0791	NLP P60 protein
LN249_07230	COG0840	transmembrane signaling receptor activity
LN249_07230	COG3290	protein histidine kinase activity
LN249_07260	COG3148	PFAM DTW domain containing protein
LN249_07265	COG1940	carbohydrate kinase activity
LN249_07275	COG0303	'Molybdopterin
LN249_07280	COG0746	molybdenum cofactor guanylyltransferase activity
LN249_07285	COG3842	ATPase activity
LN249_07290	COG4662	Binding-protein-dependent transport system inner membrane component
LN249_07300	COG2204	response regulator
LN249_07305	COG4191	Histidine kinase
LN249_07310	COG0488	(ABC) transporter
LN249_07315	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LN249_07335	COG3381	protein complex oligomerization
LN249_07345	COG0243	molybdopterin cofactor binding
LN249_07345	COG3383	formate dehydrogenase (NAD+) activity
LN249_07350	COG0437	4 iron, 4 sulfur cluster binding
LN249_07375	COG0004	ammonium transporteR
LN249_07385	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LN249_07390	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LN249_07400	COG1177	transmembrane transport
LN249_07410	COG3842	ATPase activity
LN249_07435	COG0589	response to stress
LN249_07440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LN249_07455	COG2217	Heavy metal translocating P-type atpase
LN249_07465	COG2010	Cytochrome c
LN249_07480	COG3278	Belongs to the heme-copper respiratory oxidase family
LN249_07495	COG0784	Response regulator, receiver
LN249_07495	COG2205	protein histidine kinase activity
LN249_07515	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LN249_07605	COG4128	Pfam Zonular occludens toxin
LN249_07650	COG3120	sequence-specific DNA binding
LN249_07655	COG1067	ATP-dependent peptidase activity
LN249_07660	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LN249_07675	COG0488	(ABC) transporter
LN249_07685	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LN249_07685	COG0116	Belongs to the methyltransferase superfamily
LN249_07695	COG0167	dihydroorotate dehydrogenase activity
LN249_07700	COG2902	Dehydrogenase
LN249_07710	COG0308	aminopeptidase N
LN249_07725	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
LN249_07730	COG1956	GAF domain-containing protein
LN249_07735	COG1132	(ABC) transporter
LN249_07740	COG2995	paraquat-inducible protein a
LN249_07745	COG3008	intermembrane lipid transfer
LN249_07770	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LN249_07775	COG1666	GTP binding
LN249_07785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LN249_07795	COG4597	amino acid ABC transporter
LN249_07800	COG0765	amino acid transport
LN249_07805	COG1126	abc transporter atp-binding protein
LN249_07810	COG0670	Belongs to the BI1 family
LN249_07820	COG2920	part of a sulfur-relay system
LN249_07825	COG1254	Belongs to the acylphosphatase family
LN249_07880	COG3706	GGDEF domain
LN249_07885	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LN249_07890	COG0602	queuosine metabolic process
LN249_07895	COG0561	phosphatase activity
LN249_07920	COG2828	Protein conserved in bacteria
LN249_07930	COG0372	Belongs to the citrate synthase family
LN249_07935	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LN249_07970	COG0730	response to heat
LN249_07975	COG2358	TRAP transporter, solute receptor (TAXI family
LN249_07995	COG0457	Tetratricopeptide repeat
LN249_08065	COG4790	Type iii secretion
LN249_08070	COG4794	Type iii secretion
LN249_08075	COG4791	protein targeting
LN249_08080	COG4792	protein secretion
LN249_08110	COG1028	Short-chain dehydrogenase reductase Sdr
LN249_08140	COG3177	Filamentation induced by cAMP protein fic
LN249_08160	COG4669	(LipO)protein
LN249_08230	COG1012	belongs to the aldehyde dehydrogenase family
LN249_08235	COG3284	Transcriptional regulator
LN249_08255	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LN249_08260	COG0363	glucosamine-6-phosphate deaminase activity
LN249_08265	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LN249_08280	COG4565	transcriptional regulatory protein
LN249_08285	COG3290	protein histidine kinase activity
LN249_08300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LN249_08315	COG1566	PFAM secretion protein HlyD family protein
LN249_08325	COG0583	DNA-binding transcription factor activity
LN249_08355	COG1280	lysine exporter protein (LysE YggA)
LN249_08360	COG5507	3-demethylubiquinone-9 3-methyltransferase
LN249_08410	COG0625	glutathione transferase activity
LN249_08570	COG0456	acetyltransferase
LN249_08655	COG1335	isochorismatase
LN249_08690	COG0346	lactoylglutathione lyase activity
LN249_08775	COG0791	NLP P60 protein
LN249_08810	COG0307	riboflavin synthase, alpha
LN249_09190	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LN249_09260	COG1280	lysine exporter protein (LysE YggA)
LN249_09320	COG0346	lactoylglutathione lyase activity
LN249_09460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LN249_09470	COG3768	UPF0283 membrane protein
LN249_09475	COG3106	COG3106 Predicted ATPase
LN249_09490	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LN249_09495	COG2205	protein histidine kinase activity
LN249_09495	COG0784	Response regulator, receiver
LN249_09505	COG0494	nUDIX hydrolase
LN249_09510	COG0814	amino acid
LN249_09515	COG1760	l-serine dehydratase
LN249_09520	COG2200	EAL domain
LN249_09530	COG0720	synthase
LN249_09535	COG0840	transmembrane signaling receptor activity
LN249_09550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LN249_09565	COG1448	Aminotransferase
LN249_09585	COG0840	transmembrane signaling receptor activity
LN249_09590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LN249_09620	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LN249_09635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LN249_09640	COG3108	Peptidase M15
LN249_09645	COG2989	Protein conserved in bacteria
LN249_09670	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LN249_09680	COG3088	subunit of a heme lyase
LN249_09680	COG4235	cytochrome complex assembly
LN249_09690	COG1138	Cytochrome C-type biogenesis protein
LN249_09695	COG3301	Polysulphide reductase, NrfD
LN249_09700	COG0437	4 iron, 4 sulfur cluster binding
LN249_09710	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
LN249_09730	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LN249_09735	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LN249_09765	COG0019	diaminopimelate decarboxylase activity
LN249_09805	COG0322	excinuclease ABC activity
LN249_09810	COG2197	response regulator
LN249_09815	COG0417	DNA replication proofreading
LN249_09835	COG1187	pseudouridine synthase activity
LN249_09845	COG0009	L-threonylcarbamoyladenylate synthase
LN249_09850	COG0613	PHP domain protein
LN249_09860	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LN249_09865	COG0512	Glutamine amidotransferase of anthranilate synthase
LN249_09875	COG0134	indole-3-glycerol-phosphate synthase activity
LN249_09875	COG0135	phosphoribosylanthranilate isomerase activity
LN249_09885	COG0159	tryptophan synthase activity
LN249_09890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LN249_09895	COG0318	PFAM AMP-dependent synthetase and ligase
LN249_09900	COG1301	dicarboxylic acid transport
LN249_09920	COG2917	probably involved in intracellular septation
LN249_09930	COG2350	Protein conserved in bacteria
LN249_09940	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LN249_09945	COG0583	DNA-binding transcription factor activity
LN249_09960	COG5001	Diguanylate cyclase
LN249_09965	COG1032	radical SAM domain protein
LN249_09980	COG0840	transmembrane signaling receptor activity
LN249_09985	COG0745	RESPONSE REGULATOR receiver
LN249_09990	COG3850	Histidine kinase
LN249_09990	COG5002	protein histidine kinase activity
LN249_10035	COG1335	isochorismatase
LN249_10040	COG0577	efflux transmembrane transporter activity
LN249_10040	COG1136	(ABC) transporter
LN249_10050	COG0577	efflux transmembrane transporter activity
LN249_10050	COG1136	(ABC) transporter
LN249_10060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LN249_10075	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LN249_10090	COG3118	belongs to the thioredoxin family
LN249_10095	COG4232	protein-disulfide reductase activity
LN249_10130	COG2863	cytochrome
LN249_10135	COG3258	Cytochrome c
LN249_10140	COG2995	paraquat-inducible protein a
LN249_10145	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LN249_10145	COG3008	intermembrane lipid transfer
LN249_10160	COG4166	transmembrane transport
LN249_10170	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LN249_10175	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
LN249_10185	COG0539	negative regulation of cytoplasmic translation
LN249_10190	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LN249_10195	COG0616	signal peptide processing
LN249_10200	COG1028	Short-chain dehydrogenase reductase Sdr
LN249_10215	COG0587	DNA-directed DNA polymerase activity
LN249_10220	COG0784	Response regulator, receiver
LN249_10220	COG0835	chemotaxis
LN249_10225	COG1940	carbohydrate kinase activity
LN249_10230	COG0469	pyruvate kinase activity
LN249_10235	COG4667	esterase of the alpha-beta hydrolase superfamily
LN249_10250	COG0733	neurotransmitter:sodium symporter activity
LN249_10265	COG1263	PTS System
LN249_10265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LN249_10270	COG0084	hydrolase, TatD family'
LN249_10275	COG0470	DNA polymerase III
LN249_10280	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LN249_10285	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LN249_10315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LN249_10320	COG0416	fatty acid biosynthetic process
LN249_10330	COG1399	metal-binding, possibly nucleic acid-binding protein
LN249_10335	COG0424	maF-like protein
LN249_10340	COG0564	pseudouridine synthase activity
LN249_10345	COG1530	ribonuclease E activity
LN249_10350	COG0659	secondary active sulfate transmembrane transporter activity
LN249_10355	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LN249_10360	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
LN249_10370	COG0572	uridine kinase
LN249_10380	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LN249_10380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LN249_10390	COG2186	Transcriptional regulator
LN249_10395	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LN249_10400	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LN249_10405	COG0653	protein targeting
LN249_10410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LN249_10415	COG3706	GGDEF domain
LN249_10420	COG0366	Alpha amylase catalytic
LN249_10425	COG1122	ATPase activity
LN249_10430	COG4120	Belongs to the binding-protein-dependent transport system permease family
LN249_10440	COG3092	negative regulation of chromosome organization
LN249_10445	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LN249_10450	COG0280	phosphate acetyltransferase
LN249_10450	COG0857	belongs to the CobB CobQ family
LN249_10455	COG3174	membrane
LN249_10465	COG0435	Glutathione S-transferase
LN249_10475	COG0444	Belongs to the ABC transporter superfamily
LN249_10480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LN249_10485	COG0601	transmembrane transport
LN249_10495	COG0314	molybdopterin synthase activity
LN249_10500	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LN249_10505	COG0315	cyclic pyranopterin monophosphate synthase activity
LN249_10510	COG0521	Mo-molybdopterin cofactor biosynthetic process
LN249_10515	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LN249_10520	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LN249_10525	COG2198	Histidine kinase
LN249_10530	COG2204	response regulator
LN249_10535	COG0556	nucleotide-excision repair
LN249_10545	COG4657	Part of a membrane complex involved in electron transport
LN249_10550	COG2878	Part of a membrane complex involved in electron transport
LN249_10555	COG4656	Part of a membrane complex involved in electron transport
LN249_10560	COG4658	electron transport chain
LN249_10565	COG4659	FMN binding
LN249_10570	COG4660	Part of a membrane complex involved in electron transport
LN249_10575	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LN249_10580	COG0346	lactoylglutathione lyase activity
LN249_10590	COG2885	chlorophyll binding
LN249_10595	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LN249_10600	COG2056	Na+-H+ antiporter family
LN249_10610	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LN249_10630	COG1012	belongs to the aldehyde dehydrogenase family
LN249_10630	COG1454	alcohol dehydrogenase
LN249_10635	COG2095	MarC family integral membrane protein
LN249_10640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LN249_10645	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LN249_10650	COG1757	Na H antiporter
LN249_10665	COG3081	Nucleoid-associated protein
LN249_10670	COG3082	Protein of unknown function (DUF1414)
LN249_10685	COG0123	including yeast histone deacetylase and acetoin utilization protein
LN249_10705	COG0778	Nitroreductase
LN249_10715	COG0446	pyridine nucleotide-disulphide oxidoreductase
LN249_10715	COG1902	pentaerythritol trinitrate reductase activity
LN249_10720	COG0616	signal peptide processing
LN249_10725	COG0252	asparaginase activity
LN249_10730	COG3139	Protein of unknown function (DUF1315)
LN249_10740	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LN249_10745	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LN249_10760	COG2226	methyltransferase
LN249_10775	COG1785	Belongs to the alkaline phosphatase family
LN249_10785	COG0346	lactoylglutathione lyase activity
LN249_10795	COG0668	transmembrane transport
LN249_10800	COG2983	Belongs to the UPF0260 family
LN249_10805	COG2261	transglycosylase associated protein
LN249_10820	COG3681	Belongs to the UPF0597 family
LN249_10825	COG0251	oxidation-reduction process
LN249_10830	COG0814	amino acid
LN249_10835	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LN249_10840	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LN249_10850	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LN249_10855	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LN249_10860	COG2832	Protein of unknown function (DUF454)
LN249_10865	COG0745	RESPONSE REGULATOR receiver
LN249_10870	COG0583	DNA-binding transcription factor activity
LN249_10875	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LN249_10880	COG1286	toxin biosynthetic process
LN249_10885	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
LN249_10890	COG0285	dihydrofolate synthase activity
LN249_10895	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LN249_10900	COG0101	tRNA pseudouridine synthase activity
LN249_10910	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LN249_10915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LN249_10920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LN249_10925	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LN249_10925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LN249_10940	COG3101	peptidyl-lysine hydroxylation
LN249_10945	COG2860	membrane
LN249_10950	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LN249_10955	COG2890	protein-(glutamine-N5) methyltransferase activity
LN249_10960	COG2840	Smr protein MutS2
LN249_10965	COG2062	phosphohistidine phosphatase, SixA
LN249_10980	COG1024	Enoyl-CoA hydratase
LN249_10980	COG1250	3-hydroxyacyl-CoA dehydrogenase
LN249_10985	COG0183	Belongs to the thiolase family
LN249_11015	COG3088	subunit of a heme lyase
LN249_11015	COG4235	cytochrome complex assembly
LN249_11025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LN249_11030	COG1138	Cytochrome C-type biogenesis protein
LN249_11035	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LN249_11040	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LN249_11045	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LN249_11050	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LN249_11055	COG4133	protoheme IX ABC transporter activity
LN249_11065	COG0835	chemotaxis
LN249_11075	COG1192	Involved in chromosome partitioning
LN249_11080	COG2201	protein-glutamate methylesterase activity
LN249_11085	COG2198	Histidine kinase
LN249_11085	COG0784	Response regulator, receiver
LN249_11085	COG0643	Histidine kinase
LN249_11090	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LN249_11130	COG1987	bacterial-type flagellum assembly
LN249_11180	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LN249_11190	COG1677	Flagellar hook-basal body complex protein FliE
LN249_11210	COG1516	flagellar protein fliS
LN249_11220	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LN249_11225	COG1334	flagellar protein FlaG
LN249_11230	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LN249_11240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LN249_11245	COG2837	iron assimilation
LN249_11270	COG1393	Belongs to the ArsC family
LN249_11275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LN249_11290	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
LN249_11295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LN249_11305	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LN249_11320	COG4783	chaperone-mediated protein folding
LN249_11325	COG1393	Belongs to the ArsC family
LN249_11345	COG2233	PERMEase
LN249_11350	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LN249_11355	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LN249_11360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LN249_11365	COG0121	glutamine amidotransferase
LN249_11370	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LN249_11375	COG1960	acyl-CoA dehydrogenase activity
LN249_11410	COG0328	RNA-DNA hybrid ribonuclease activity
LN249_11415	COG2226	methyltransferase
LN249_11420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LN249_11425	COG0741	lytic transglycosylase activity
LN249_11425	COG1388	LysM domain
LN249_11435	COG3021	interspecies interaction between organisms
LN249_11440	COG0347	Belongs to the P(II) protein family
LN249_11455	COG0825	malonyl-CoA metabolic process
LN249_11460	COG0587	DNA-directed DNA polymerase activity
LN249_11470	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LN249_11475	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LN249_11485	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LN249_11490	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
LN249_11500	COG0750	zinc metalloprotease
LN249_11505	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LN249_11510	COG0575	Belongs to the CDS family
LN249_11515	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LN249_11520	COG0233	cytoplasmic translational termination
LN249_11525	COG0528	UMP kinase activity
LN249_11530	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LN249_11535	COG0052	Belongs to the universal ribosomal protein uS2 family
LN249_11540	COG0024	Methionine aminopeptidase
LN249_11545	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LN249_11555	COG0564	pseudouridine synthase activity
LN249_11590	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LN249_11595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LN249_11620	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LN249_11630	COG0254	rRNA binding
LN249_11635	COG1720	tRNA m6t6A37 methyltransferase activity
LN249_11660	COG0733	neurotransmitter:sodium symporter activity
LN249_11675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LN249_11680	COG0514	ATP-dependent DNA helicase (RecQ)
LN249_11685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LN249_11700	COG1477	protein flavinylation
LN249_11705	COG2871	sodium ion transport
LN249_11710	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LN249_11715	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LN249_11720	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LN249_11725	COG1805	sodium ion transport
LN249_11730	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LN249_11735	COG0271	Belongs to the BolA IbaG family
LN249_11740	COG2813	Specifically methylates the guanine in position
LN249_11745	COG3056	Lipoprotein
LN249_11765	COG1595	DNA-templated transcription, initiation
LN249_11785	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LN249_11790	COG0693	protein deglycase activity
LN249_11795	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LN249_11800	COG3706	GGDEF domain
LN249_11805	COG2166	iron-sulfur cluster assembly
LN249_11810	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LN249_11815	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LN249_11825	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LN249_11825	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LN249_11835	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LN249_11840	COG1074	ATP-dependent DNA helicase activity
LN249_11845	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LN249_11865	COG3141	response to X-ray
LN249_11870	COG2171	N-acyltransferase activity
LN249_11875	COG0584	glycerophosphoryl diester phosphodiesterase
LN249_11880	COG2271	Major facilitator Superfamily
LN249_11885	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LN249_11890	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LN249_11895	COG1349	DNA-binding transcription factor activity
LN249_11900	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LN249_11925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LN249_11930	COG1609	Transcriptional regulator
LN249_11935	COG2211	Major facilitator Superfamily
LN249_11950	COG2017	converts alpha-aldose to the beta-anomer
LN249_11955	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LN249_11965	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LN249_11970	COG1609	Transcriptional regulator
LN249_11975	COG3250	beta-galactosidase activity
LN249_11980	COG2731	YhcH YjgK YiaL family protein
LN249_11985	COG0531	amino acid
LN249_11990	COG0583	DNA-binding transcription factor activity
LN249_12050	COG4964	Belongs to the GSP D family
LN249_12075	COG2169	Transcriptional regulator
LN249_12080	COG1022	Amp-dependent synthetase and ligase
LN249_12090	COG0583	DNA-binding transcription factor activity
LN249_12095	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LN249_12100	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LN249_12110	COG0560	Phosphoserine phosphatase
LN249_12120	COG0813	purine-nucleoside phosphorylase activity
LN249_12125	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LN249_12130	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
LN249_12140	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LN249_12145	COG0084	hydrolase, TatD family'
LN249_12155	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LN249_12175	COG3153	acetyltransferase
LN249_12180	COG3154	lipid carrier protein
LN249_12190	COG0826	peptidase U32
LN249_12200	COG0534	Mate efflux family protein
LN249_12215	COG1185	polyribonucleotide nucleotidyltransferase activity
LN249_12220	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LN249_12225	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LN249_12230	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LN249_12235	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LN249_12240	COG0195	Participates in both transcription termination and antitermination
LN249_12245	COG0779	Required for maturation of 30S ribosomal subunits
LN249_12260	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LN249_12265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LN249_12270	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LN249_12275	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LN249_12280	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LN249_12285	COG1534	Rna-binding protein
LN249_12290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LN249_12295	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LN249_12300	COG2027	D-alanyl-D-alanine carboxypeptidase
LN249_12310	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LN249_12315	COG0739	heme binding
LN249_12320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LN249_12335	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LN249_12340	COG0628	permease
LN249_12350	COG0784	Response regulator, receiver
LN249_12350	COG2205	protein histidine kinase activity
LN249_12355	COG0747	negative chemotaxis
LN249_12365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LN249_12370	COG0444	Belongs to the ABC transporter superfamily
LN249_12375	COG4608	Belongs to the ABC transporter superfamily
LN249_12385	COG2971	BadF BadG BcrA BcrD
LN249_12400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LN249_12405	COG3842	ATPase activity
LN249_12415	COG1840	ABC-type Fe3 transport system, periplasmic component
LN249_12420	COG0004	ammonium transporteR
LN249_12425	COG0347	Belongs to the P(II) protein family
LN249_12430	COG3112	Uncharacterised protein family (UPF0231)
LN249_12435	COG1049	propionate catabolic process, 2-methylcitrate cycle
LN249_12440	COG1752	Esterase of the alpha-beta hydrolase superfamily
LN249_12445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LN249_12450	COG1643	Atp-dependent helicase
LN249_12455	COG1489	DNA binding
LN249_12465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LN249_12475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LN249_12480	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LN249_12485	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LN249_12490	COG1560	Kdo2-lipid A biosynthetic process
LN249_12495	COG0842	Transport permease protein
LN249_12500	COG1131	(ABC) transporter
LN249_12505	COG0659	secondary active sulfate transmembrane transporter activity
LN249_12510	COG0288	reversible hydration of carbon dioxide
LN249_12525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LN249_12530	COG0508	dehydrogenase complex catalyzes the overall conversion of
LN249_12535	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LN249_12540	COG2186	Transcriptional regulator
LN249_12550	COG0157	Belongs to the NadC ModD family
LN249_12560	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LN249_12565	COG1459	type II secretion system
LN249_12575	COG0237	dephospho-CoA kinase activity
LN249_12580	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
LN249_12585	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LN249_12600	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LN249_12605	COG0228	four-way junction DNA binding
LN249_12610	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LN249_12615	COG4137	Cytochrome C assembly protein
LN249_12620	COG4536	flavin adenine dinucleotide binding
LN249_12625	COG1854	S-ribosylhomocysteine lyase activity
LN249_12640	COG0612	Peptidase, M16
LN249_12645	COG1238	metal cluster binding
LN249_12655	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
LN249_12660	COG0511	ligase activity, forming carbon-carbon bonds
LN249_12660	COG5016	pyruvate
LN249_12665	COG3630	sodium ion export across plasma membrane
LN249_12725	COG0527	aspartate kinase activity
LN249_12730	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LN249_12735	COG2137	regulation of response to DNA damage stimulus
LN249_12740	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LN249_12745	COG1546	Belongs to the CinA family
LN249_12750	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LN249_12755	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LN249_12760	COG4942	peptidase
LN249_12760	COG1388	LysM domain
LN249_12765	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LN249_12770	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LN249_12780	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LN249_12785	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LN249_12790	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LN249_12795	COG0148	phosphopyruvate hydratase activity
LN249_12800	COG0504	CTP synthase activity
LN249_12805	COG3956	TIGRFAM MazG family protein
LN249_12810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LN249_12815	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LN249_12825	COG0736	holo-[acyl-carrier-protein] synthase activity
LN249_12830	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LN249_12835	COG1381	Involved in DNA repair and RecF pathway recombination
LN249_12840	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LN249_12855	COG0481	GTPase activity
LN249_12860	COG3086	response to oxidative stress
LN249_12875	COG1595	DNA-templated transcription, initiation
LN249_12880	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LN249_12885	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LN249_12890	COG0354	folic acid binding
LN249_12905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LN249_12910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LN249_12915	COG3079	Belongs to the UPF0149 family
LN249_12920	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
LN249_12930	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LN249_12935	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LN249_12940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LN249_12950	COG0583	DNA-binding transcription factor activity
LN249_12965	COG0668	transmembrane transport
LN249_12970	COG0191	fructose-bisphosphate aldolase activity
LN249_12975	COG0126	phosphoglycerate kinase activity
LN249_12980	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LN249_12985	COG4771	TonB-dependent receptor
LN249_12990	COG0583	DNA-binding transcription factor activity
LN249_12995	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LN249_13000	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LN249_13015	COG2356	endonuclease I
LN249_13020	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LN249_13025	COG0189	ligase activity
LN249_13035	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LN249_13050	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LN249_13055	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LN249_13060	COG0762	integral membrane protein
LN249_13065	COG1872	DUF167
LN249_13075	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LN249_13080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LN249_13085	COG2066	Belongs to the glutaminase family
LN249_13095	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LN249_13105	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
LN249_13180	COG1012	belongs to the aldehyde dehydrogenase family
LN249_13225	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LN249_13235	COG3394	polysaccharide catabolic process
LN249_13240	COG1486	melibiose metabolic process
LN249_13245	COG1447	Phosphotransferase system cellobiose-specific component IIA
LN249_13250	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LN249_13255	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LN249_13260	COG0726	polysaccharide deacetylase
LN249_13270	COG1028	Short-chain dehydrogenase reductase Sdr
LN249_13285	COG0795	lipopolysaccharide-transporting ATPase activity
LN249_13290	COG0795	lipopolysaccharide-transporting ATPase activity
LN249_13300	COG2927	DNA polymerase III (CHI subunit)
LN249_13305	COG0525	valine-tRNA ligase activity
LN249_13345	COG0540	Belongs to the ATCase OTCase family
LN249_13350	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
LN249_13355	COG0251	oxidation-reduction process
LN249_13360	COG0204	Acyl-transferase
LN249_13370	COG5007	Belongs to the BolA IbaG family
LN249_13380	COG2854	intermembrane phospholipid transfer
LN249_13385	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LN249_13390	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LN249_13395	COG1127	ABC transporter
LN249_13415	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LN249_13420	COG1137	ATPase activity
LN249_13430	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LN249_13435	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LN249_13440	COG1660	Displays ATPase and GTPase activities
LN249_13445	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LN249_13450	COG2239	Acts as a magnesium transporter
LN249_13455	COG0312	modulator of DNA gyrase
LN249_13460	COG3028	Belongs to the UPF0307 family
LN249_13465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LN249_13470	COG0564	pseudouridine synthase activity
LN249_13480	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LN249_13485	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LN249_13490	COG0312	modulator of DNA gyrase
LN249_13495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LN249_13500	COG3164	Protein of unknown function
LN249_13510	COG0424	maF-like protein
LN249_13515	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LN249_13520	COG1792	Involved in formation and maintenance of cell shape
LN249_13525	COG1077	Cell shape determining protein MreB Mrl
LN249_13570	COG1459	type II secretion system
LN249_13575	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LN249_13585	COG3267	Type II secretory pathway component ExeA
LN249_13585	COG3409	Peptidoglycan-binding domain 1 protein
LN249_13590	COG1450	Type ii and iii secretion system protein
LN249_13610	COG2199	diguanylate cyclase activity
LN249_13610	COG2200	EAL domain
LN249_13615	COG0629	single-stranded DNA binding
LN249_13630	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LN249_13640	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LN249_13645	COG0527	aspartate kinase activity
LN249_13650	COG0646	methionine synthase
LN249_13650	COG1410	methionine synthase
LN249_13710	COG0175	sulfate reduction
LN249_13715	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LN249_13720	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LN249_13740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LN249_13745	COG0735	belongs to the Fur family
LN249_13755	COG0166	Belongs to the GPI family
LN249_13760	COG0432	Pfam Uncharacterised protein family UPF0047
LN249_13765	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LN249_13790	COG2965	DNA replication, synthesis of RNA primer
LN249_13795	COG0360	Binds together with S18 to 16S ribosomal RNA
LN249_13800	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LN249_13805	COG0338	D12 class N6 adenine-specific DNA methyltransferase
LN249_13815	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LN249_13820	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LN249_13850	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LN249_13860	COG0678	peroxiredoxin activity
LN249_13860	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LN249_13875	COG0165	Argininosuccinate lyase
LN249_13875	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LN249_13880	COG0137	argininosuccinate synthase activity
LN249_13900	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LN249_13910	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LN249_13915	COG0460	homoserine dehydrogenase
LN249_13915	COG0527	aspartate kinase activity
LN249_13920	COG0626	cystathionine gamma-synthase activity
LN249_13925	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
LN249_13930	COG0281	malic enzyme
LN249_13940	COG2906	2 iron, 2 sulfur cluster binding
LN249_13945	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LN249_13950	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LN249_13965	COG2168	tRNA wobble position uridine thiolation
LN249_13970	COG2923	Belongs to the DsrF TusC family
LN249_13975	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LN249_13980	COG2964	Protein conserved in bacteria
LN249_13985	COG0545	Peptidyl-prolyl cis-trans isomerase
LN249_14000	COG1446	asparaginase
LN249_14005	COG1047	Peptidyl-prolyl cis-trans
LN249_14020	COG2249	NAD(P)H dehydrogenase (quinone) activity
LN249_14025	COG0488	(ABC) transporter
LN249_14035	COG0429	hydrolase of the alpha beta-hydrolase fold
LN249_14045	COG3954	Phosphoribulokinase
LN249_14050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LN249_14070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LN249_14075	COG0512	Glutamine amidotransferase of anthranilate synthase
LN249_14090	COG0180	Tryptophanyl-tRNA synthetase
LN249_14095	COG0546	phosphoglycolate phosphatase activity
LN249_14100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LN249_14105	COG0557	exoribonuclease II activity
LN249_14110	COG1959	2 iron, 2 sulfur cluster binding
LN249_14115	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LN249_14115	COG1017	nitric oxide dioxygenase activity
LN249_14120	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
LN249_14125	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LN249_14130	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
LN249_14135	COG0330	HflC and HflK could
LN249_14140	COG0330	HflC and HflK could
LN249_14145	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LN249_14155	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LN249_14160	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LN249_14170	COG0802	atpase or kinase
LN249_14175	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LN249_14240	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LN249_14245	COG1162	GTPase activity
LN249_14250	COG0688	phosphatidylethanolamine metabolic process
LN249_14255	COG0471	metal ion transport
LN249_14255	COG3273	potassium ion transport
LN249_14265	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LN249_14270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LN249_14275	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LN249_14280	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LN249_14285	COG1045	serine acetyltransferase
LN249_14290	COG4942	peptidase
LN249_14310	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LN249_14315	COG1053	succinate dehydrogenase
LN249_14320	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LN249_14325	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
LN249_14345	COG1509	lysine 2,3-aminomutase activity
LN249_14350	COG1285	pathogenesis
LN249_14360	COG0459	protein refolding
LN249_14370	COG0534	Mate efflux family protein
LN249_14375	COG0205	6-phosphofructokinase activity
LN249_14380	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LN249_14385	COG3678	ATP-independent chaperone mediated protein folding
LN249_14390	COG0745	RESPONSE REGULATOR receiver
LN249_14395	COG2205	protein histidine kinase activity
LN249_14405	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LN249_14410	COG3030	protein affecting phage T7 exclusion by the F plasmid
LN249_14415	COG1027	Aspartate ammonia-lyase
LN249_14420	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LN249_14425	COG4232	protein-disulfide reductase activity
LN249_14435	COG3263	regulation of cellular component size
LN249_14445	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LN249_14470	COG2814	Major facilitator Superfamily
LN249_14485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LN249_14490	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LN249_14495	COG0511	ligase activity, forming carbon-carbon bonds
LN249_14500	COG0439	Biotin carboxylase
LN249_14505	COG2264	protein methyltransferase activity
LN249_14510	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LN249_14515	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LN249_14525	COG0488	(ABC) transporter
LN249_14580	COG1982	Orn Lys Arg decarboxylase major
LN249_14585	COG0531	amino acid
LN249_14590	COG3710	Transcriptional regulator
LN249_14595	COG0789	Transcriptional regulator
LN249_14600	COG0138	bifunctional purine biosynthesis protein purh
LN249_14605	COG0151	Belongs to the GarS family
LN249_14620	COG1253	flavin adenine dinucleotide binding
LN249_14625	COG3068	Protein conserved in bacteria
LN249_14635	COG1573	uracil-dna glycosylase
LN249_14640	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LN249_14645	COG2816	NAD+ diphosphatase activity
LN249_14650	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
LN249_14655	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LN249_14660	COG0085	RNA polymerase activity
LN249_14665	COG0222	ribosome binding
LN249_14670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LN249_14685	COG0250	Participates in transcription elongation, termination and antitermination
LN249_14690	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LN249_14725	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LN249_14725	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LN249_14730	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LN249_14740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LN249_14805	COG4206	TonB-dependent receptor
LN249_14825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LN249_14830	COG0534	Mate efflux family protein
LN249_14835	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LN249_14840	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LN249_14845	COG2937	Belongs to the GPAT DAPAT family
LN249_14850	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LN249_14855	COG3161	chorismate lyase activity
LN249_14860	COG1580	Controls the rotational direction of flagella during chemotaxis
LN249_14865	COG0705	Rhomboid family
LN249_14870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LN249_14880	COG2177	Part of the ABC transporter FtsEX involved in
LN249_14885	COG2884	Cell division ATP-binding protein ftsE
LN249_14890	COG0552	protein localization to endoplasmic reticulum
LN249_14895	COG0742	ribosomal rna small subunit methyltransferase
LN249_14905	COG2095	MarC family integral membrane protein
LN249_14945	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LN249_14950	COG0640	Transcriptional regulator
LN249_14955	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LN249_14960	COG1280	lysine exporter protein (LysE YggA)
LN249_14965	COG2267	carboxylic ester hydrolase activity
LN249_14970	COG0561	phosphatase activity
LN249_14985	COG3148	PFAM DTW domain containing protein
LN249_14990	COG2199	diguanylate cyclase activity
LN249_14990	COG2200	EAL domain
LN249_14990	COG3287	FIST C domain
LN249_14995	COG1011	Hydrolase
LN249_15000	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LN249_15010	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LN249_15015	COG0019	diaminopimelate decarboxylase activity
LN249_15025	COG1965	Belongs to the frataxin family
LN249_15030	COG3072	Adenylate cyclase
LN249_15035	COG0181	hydroxymethylbilane synthase activity
LN249_15040	COG1587	Uroporphyrinogen-III synthase
LN249_15045	COG2959	enzyme of heme biosynthesis
LN249_15050	COG3071	HemY protein
LN249_15090	COG0633	Ferredoxin
LN249_15095	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LN249_15110	COG3118	belongs to the thioredoxin family
LN249_15115	COG0513	Belongs to the DEAD box helicase family
LN249_15120	COG0248	Ppx GppA phosphatase
LN249_15125	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LN249_15135	COG0514	ATP-dependent DNA helicase (RecQ)
LN249_15140	COG2962	Rard protein
LN249_15150	COG1280	lysine exporter protein (LysE YggA)
LN249_15155	COG0405	Gamma-glutamyltransferase
LN249_15160	COG0210	DNA helicase
LN249_15170	COG3220	belongs to the UPF0276 family
LN249_15200	COG0006	proline dipeptidase activity
LN249_15200	COG0006	proline dipeptidase activity
LN249_15215	COG2104	thiamine diphosphate biosynthetic process
LN249_15220	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LN249_15235	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LN249_15240	COG2132	Multicopper oxidase
LN249_15290	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LN249_15300	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LN249_15305	COG0408	coproporphyrinogen oxidase activity
LN249_15310	COG0009	L-threonylcarbamoyladenylate synthase
LN249_15315	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LN249_15320	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LN249_15325	COG0551	DNA topoisomerase type I activity
LN249_15330	COG2922	Belongs to the Smg family
LN249_15335	COG0758	DNA mediated transformation
LN249_15345	COG0242	peptide deformylase activity
LN249_15350	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LN249_15355	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LN249_15355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LN249_15360	COG0569	domain protein
LN249_15365	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LN249_15375	COG1272	protein, Hemolysin III
LN249_15380	COG4326	sporulation control protein
LN249_15390	COG3084	Protein conserved in bacteria
LN249_15400	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LN249_15405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LN249_15410	COG0204	Acyl-transferase
LN249_15420	COG0606	chelatase, subunit chli
LN249_15430	COG3978	acetolactate synthase activity
LN249_15435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LN249_15440	COG0129	dihydroxy-acid dehydratase activity
LN249_15450	COG0583	DNA-binding transcription factor activity
LN249_15455	COG2814	Major facilitator Superfamily
LN249_15465	COG0765	amino acid transport
LN249_15475	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LN249_15480	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LN249_15485	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LN249_15490	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LN249_15495	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LN249_15500	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LN249_15510	COG0356	it plays a direct role in the translocation of protons across the membrane
LN249_15515	COG3312	ion transport
LN249_15520	COG1475	DNA binding
LN249_15525	COG1192	Involved in chromosome partitioning
LN249_15530	COG0357	Ribosomal RNA small subunit methyltransferase G
LN249_15535	COG0445	tRNA wobble uridine modification
LN249_15540	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LN249_15550	COG0706	membrane insertase activity
LN249_15560	COG0594	ribonuclease P activity
LN249_15570	COG1126	abc transporter atp-binding protein
LN249_15595	COG0596	Alpha beta hydrolase
LN249_15620	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LN249_15630	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LN249_15645	COG2259	Doxx family
LN249_15650	COG1741	Belongs to the pirin family
LN249_15670	COG0363	glucosamine-6-phosphate deaminase activity
LN249_15680	COG0786	glutamate:sodium symporter activity
LN249_15685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LN249_15690	COG1131	(ABC) transporter
LN249_15700	COG0786	glutamate:sodium symporter activity
LN249_15720	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LN249_15730	COG3279	Response regulator of the LytR AlgR family
LN249_15735	COG3275	phosphorelay sensor kinase activity
LN249_15755	COG1136	(ABC) transporter
LN249_15765	COG0772	Belongs to the SEDS family
LN249_15790	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LN249_15790	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
LN249_15800	COG0444	Belongs to the ABC transporter superfamily
LN249_15805	COG4608	Belongs to the ABC transporter superfamily
LN249_15830	COG1444	tRNA N-acetyltransferase activity
LN249_15850	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LN249_15855	COG1263	PTS System
LN249_15855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LN249_15860	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LN249_15875	COG4166	transmembrane transport
LN249_15925	COG0259	pyridoxamine-phosphate oxidase activity
LN249_15950	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LN249_15985	COG1132	(ABC) transporter
LN249_15995	COG2207	Transcriptional regulator
LN249_16020	COG2258	MOSC domain
LN249_16040	COG1595	DNA-templated transcription, initiation
LN249_16065	COG3634	alkyl hydroperoxide reductase activity
LN249_16075	COG1846	Transcriptional regulator
LN249_16080	COG1764	response to oxidative stress
LN249_16095	COG0577	efflux transmembrane transporter activity
LN249_16100	COG1136	(ABC) transporter
LN249_16115	COG0463	Glycosyl transferase, family 2
LN249_16125	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LN249_16130	COG0826	peptidase U32
LN249_16155	COG1653	transport
LN249_16160	COG0019	diaminopimelate decarboxylase activity
LN249_16165	COG4264	IucA IucC family
LN249_16190	COG4772	TonB-dependent receptor
LN249_16195	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
LN249_16200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LN249_16205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LN249_16210	COG1120	ATPase activity
LN249_16215	COG0840	transmembrane signaling receptor activity
LN249_16220	COG0612	Peptidase, M16
LN249_16230	COG0739	heme binding
LN249_16270	COG4580	involved in the transport of maltose and maltodextrins
LN249_16290	COG2356	endonuclease I
LN249_16310	COG1982	Orn Lys Arg decarboxylase major
LN249_16315	COG0531	amino acid
LN249_16325	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
LN249_16330	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
LN249_16335	COG1162	GTPase activity
LN249_16340	COG1263	PTS System
LN249_16340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LN249_16345	COG1999	signal sequence binding
LN249_16360	COG2909	trisaccharide binding
LN249_16365	COG0058	SHG alpha-glucan phosphorylase activity
LN249_16370	COG1640	4-alpha-glucanotransferase
LN249_16375	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LN249_16380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LN249_16385	COG0366	Alpha amylase catalytic
LN249_16395	COG3366	ferrous iron transmembrane transporter activity
LN249_16400	COG0700	Nucleoside recognition
LN249_16405	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LN249_16410	COG3339	Conserved Protein
LN249_16415	COG1301	dicarboxylic acid transport
LN249_16435	COG1596	polysaccharide export
LN249_16450	COG2095	MarC family integral membrane protein
LN249_16455	COG4667	esterase of the alpha-beta hydrolase superfamily
LN249_16460	COG3397	chitin binding
LN249_16470	COG0415	Belongs to the DNA photolyase family
LN249_16480	COG1054	Belongs to the UPF0176 family
LN249_16495	COG1686	Belongs to the peptidase S11 family
LN249_16515	COG0583	DNA-binding transcription factor activity
LN249_16520	COG4628	conserved protein (DUF2132)
LN249_16535	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
LN249_16540	COG0628	permease
LN249_16580	COG2814	Major facilitator Superfamily
LN249_16590	COG0454	-acetyltransferase
LN249_16600	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LN249_16605	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LN249_16610	COG1882	Formate acetyltransferase
LN249_16660	COG1360	Flagellar Motor Protein
LN249_16665	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LN249_16670	COG1191	sigma factor activity
LN249_16675	COG1580	Controls the rotational direction of flagella during chemotaxis
LN249_16690	COG1516	flagellar protein fliS
LN249_16695	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LN249_16705	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LN249_16720	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LN249_16730	COG1987	bacterial-type flagellum assembly
LN249_16770	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LN249_16825	COG0346	lactoylglutathione lyase activity
LN249_16850	COG0745	RESPONSE REGULATOR receiver
LN249_16870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LN249_16875	COG5001	Diguanylate cyclase
LN249_16875	COG3300	MHYT domain
LN249_16880	COG0156	8-amino-7-oxononanoate synthase activity
LN249_16885	COG1063	alcohol dehydrogenase
LN249_16920	COG0668	transmembrane transport
LN249_16930	COG1304	FMN binding
LN249_16935	COG1620	l-lactate permease
LN249_16940	COG0583	DNA-binding transcription factor activity
LN249_16945	COG1505	serine-type exopeptidase activity
LN249_16950	COG4172	Belongs to the ABC transporter superfamily
LN249_16960	COG1067	ATP-dependent peptidase activity
LN249_16965	COG0840	transmembrane signaling receptor activity
LN249_16970	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LN249_16990	COG1247	-acetyltransferase
LN249_16995	COG0437	4 iron, 4 sulfur cluster binding
LN249_17000	COG0348	domain, Protein
LN249_17020	COG1122	ATPase activity
LN249_17025	COG4720	Psort location CytoplasmicMembrane, score
LN249_17030	COG1566	PFAM secretion protein HlyD family protein
LN249_17055	COG0813	purine-nucleoside phosphorylase activity
LN249_17060	COG3272	Protein of unknown function (DUF1722)
LN249_17065	COG0789	Transcriptional regulator
LN249_17070	COG0415	Belongs to the DNA photolyase family
LN249_17075	COG1388	LysM domain
LN249_17075	COG1376	ErfK ybiS ycfS ynhG family protein
LN249_17085	COG0513	Belongs to the DEAD box helicase family
LN249_17090	COG1770	oligopeptidase
LN249_17095	COG4771	TonB-dependent receptor
LN249_17125	COG0573	inorganic phosphate transmembrane transporter activity
LN249_17130	COG0581	inorganic phosphate transmembrane transporter activity
LN249_17135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LN249_17150	COG2304	oxidoreductase activity
LN249_17155	COG2304	oxidoreductase activity
LN249_17170	COG0714	Associated with various cellular activities
LN249_17185	COG2197	response regulator
LN249_17220	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
LN249_17225	COG1120	ATPase activity
LN249_17230	COG4774	siderophore transport
LN249_17235	COG1132	(ABC) transporter
LN249_17240	COG2205	protein histidine kinase activity
LN249_17240	COG2205	protein histidine kinase activity
LN249_17250	COG0569	domain protein
LN249_17255	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LN249_17260	COG0583	DNA-binding transcription factor activity
LN249_17275	COG1012	belongs to the aldehyde dehydrogenase family
LN249_17285	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LN249_17290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LN249_17300	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LN249_17305	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
LN249_17310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LN249_17340	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LN249_17340	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LN249_17340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LN249_17345	COG2207	Transcriptional regulator
LN249_17355	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LN249_17360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LN249_17365	COG2084	Dehydrogenase
LN249_17370	COG0753	catalase activity
LN249_17380	COG2130	NADP-dependent
LN249_17385	COG1309	transcriptional regulator
LN249_17390	COG3097	Belongs to the UPF0267 family
LN249_17430	COG0489	protein tyrosine kinase activity
LN249_17430	COG3206	protein involved in exopolysaccharide biosynthesis
LN249_17445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LN249_17450	COG3842	ATPase activity
LN249_17460	COG1175	transmembrane transport
LN249_17495	COG2354	Protein conserved in bacteria
LN249_17500	COG0418	dihydroorotase activity
LN249_17505	COG0401	homolog of Blt101
LN249_17510	COG0633	Ferredoxin
LN249_17510	COG3217	Mosc domain protein beta barrel domain protein
LN249_17510	COG0633	Ferredoxin
LN249_17510	COG3217	Mosc domain protein beta barrel domain protein
LN249_17515	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LN249_17520	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LN249_17560	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LN249_17565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LN249_17575	COG0848	biopolymer transport protein
LN249_17580	COG0811	peptide transport
LN249_17585	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
LN249_17595	COG3721	Heme iron utilization protein
LN249_17600	COG0748	coenzyme F420 binding
LN249_17610	COG0835	chemotaxis
LN249_17610	COG0784	Response regulator, receiver
LN249_17615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LN249_17650	COG0583	DNA-binding transcription factor activity
LN249_17655	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LN249_17665	COG4934	collagen metabolic process
LN249_17680	COG0789	Transcriptional regulator
LN249_17685	COG0366	Alpha amylase catalytic
LN249_17705	COG2249	NAD(P)H dehydrogenase (quinone) activity
LN249_17710	COG0589	response to stress
LN249_17715	COG0488	(ABC) transporter
LN249_17720	COG1505	serine-type exopeptidase activity
LN249_17730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LN249_17740	COG2067	long-chain fatty acid transport protein
LN249_17750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LN249_17780	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LN249_17800	COG3383	formate dehydrogenase (NAD+) activity
LN249_17815	COG0842	Transport permease protein
LN249_17820	COG1131	(ABC) transporter
LN249_17830	COG2706	6-phosphogluconolactonase activity
LN249_17840	COG1881	PFAM PEBP family protein
LN249_17850	COG0798	PFAM Bile acid sodium symporter
LN249_17865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LN249_17870	COG2213	PTS system mannitol-specific
LN249_17875	COG1063	alcohol dehydrogenase
LN249_17885	COG1072	(Pantothenic acid kinase))
LN249_17890	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LN249_17905	COG0814	amino acid
LN249_17915	COG0840	transmembrane signaling receptor activity
LN249_17920	COG3314	Sporulation integral membrane protein YlbJ
LN249_17940	COG0739	heme binding
LN249_17945	COG5001	Diguanylate cyclase
LN249_17950	COG0583	DNA-binding transcription factor activity
LN249_17955	COG2814	Major facilitator Superfamily
LN249_17970	COG0697	spore germination
LN249_17985	COG0179	Fumarylacetoacetate (FAA) hydrolase
LN249_18000	COG2207	Transcriptional regulator
LN249_18005	COG1280	lysine exporter protein (LysE YggA)
LN249_18015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LN249_18020	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LN249_18025	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LN249_18030	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
LN249_18055	COG1612	heme a metabolic process
LN249_18060	COG0109	protoheme IX farnesyltransferase activity
LN249_18065	COG0545	Peptidyl-prolyl cis-trans isomerase
LN249_18075	COG2885	chlorophyll binding
LN249_18095	COG1278	Cold shock
LN249_18100	COG3036	rescue of stalled ribosome
LN249_18105	COG2199	diguanylate cyclase activity
LN249_18125	COG0577	efflux transmembrane transporter activity
LN249_18125	COG1136	(ABC) transporter
LN249_18140	COG0783	Belongs to the Dps family
LN249_18150	COG2133	pyrroloquinoline quinone binding
LN249_18155	COG1454	alcohol dehydrogenase
LN249_18160	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
LN249_18200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LN249_18205	COG3186	Phenylalanine-4-hydroxylase
LN249_18230	COG3530	Putative quorum-sensing-regulated virulence factor
LN249_18245	COG1404	Belongs to the peptidase S8 family
LN249_18295	COG0730	response to heat
LN249_18310	COG2814	Major facilitator Superfamily
LN249_18320	COG0513	Belongs to the DEAD box helicase family
LN249_18325	COG4628	conserved protein (DUF2132)
LN249_18335	COG0133	tryptophan synthase activity
LN249_18340	COG0557	exoribonuclease II activity
LN249_18345	COG1278	Cold shock
LN249_18355	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
LN249_18365	COG0523	cobalamin synthesis protein
LN249_18370	COG0513	Belongs to the DEAD box helicase family
LN249_18390	COG2200	EAL domain
LN249_18395	COG1119	ATPase activity
LN249_18400	COG0840	transmembrane signaling receptor activity
LN249_18430	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
LN249_18435	COG0513	Belongs to the DEAD box helicase family
LN249_18445	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LN249_18500	COG0277	FAD linked oxidase domain protein
LN249_18500	COG0247	lactate metabolic process
LN249_18510	COG5413	integral membrane protein
LN249_18520	COG1024	Enoyl-CoA hydratase
LN249_18525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LN249_18530	COG1960	acyl-CoA dehydrogenase activity
LN249_18540	COG0183	Belongs to the thiolase family
LN249_18555	COG1024	Enoyl-CoA hydratase
LN249_18560	COG1024	Enoyl-CoA hydratase
LN249_18570	COG1028	Short-chain dehydrogenase reductase Sdr
LN249_18575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LN249_18580	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LN249_18585	COG1845	cytochrome c oxidase, subunit III
LN249_18590	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LN249_18595	COG0109	protoheme IX farnesyltransferase activity
LN249_18605	COG1902	pentaerythritol trinitrate reductase activity
LN249_18605	COG0446	pyridine nucleotide-disulphide oxidoreductase
LN249_18625	COG1012	belongs to the aldehyde dehydrogenase family
LN249_18635	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LN249_18665	COG1126	abc transporter atp-binding protein
LN249_18670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LN249_18675	COG4215	(ABC) transporter
LN249_18680	COG4160	amino acid transport
LN249_18745	COG0443	Heat shock 70 kDa protein
LN249_18750	COG2847	Copper chaperone PCu(A)C
LN249_18820	COG0814	amino acid
LN249_18830	COG0243	molybdopterin cofactor binding
LN249_18835	COG1648	precorrin-2 dehydrogenase activity
LN249_18835	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LN249_18855	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LN249_18855	COG1116	anion transmembrane transporter activity
LN249_18860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LN249_18865	COG1116	anion transmembrane transporter activity
LN249_18870	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LN249_18870	COG2146	nitrite reductase [NAD(P)H] activity
LN249_18890	COG0625	glutathione transferase activity
LN249_18920	COG0515	serine threonine protein kinase
LN249_18920	COG2815	serine threonine protein kinase
LN249_18955	COG0631	protein serine/threonine phosphatase activity
LN249_19025	COG0420	3'-5' exonuclease activity
LN249_19030	COG0419	ATPase involved in DNA repair
LN249_19045	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LN249_19045	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LN249_19055	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LN249_19075	COG0251	oxidation-reduction process
LN249_19085	COG3040	lipid binding
LN249_19095	COG1288	antiporter activity
LN249_19105	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
LN249_19120	COG2425	protein containing a von Willebrand factor type A (vWA) domain
LN249_19135	COG0583	DNA-binding transcription factor activity
LN249_19140	COG0277	FAD linked oxidase domain protein
LN249_19155	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LN249_19225	COG5001	Diguanylate cyclase
LN249_19230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LN249_19235	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LN249_19245	COG2116	formate transmembrane transporter activity
LN249_19265	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LN249_19300	COG3118	belongs to the thioredoxin family
LN249_19305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LN249_19330	COG2271	Major facilitator Superfamily
LN249_19335	COG3851	Histidine kinase
LN249_19340	COG2197	response regulator
LN249_19350	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LN249_19355	COG0583	DNA-binding transcription factor activity
LN249_19360	COG0243	molybdopterin cofactor binding
LN249_19370	COG0384	phenazine biosynthesis protein PhzF
LN249_19405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LN249_19420	COG1328	CTP reductase activity
LN249_19425	COG0602	queuosine metabolic process
LN249_19430	COG0534	Mate efflux family protein
LN249_19435	COG2207	Transcriptional regulator
LN249_19445	COG4067	protein conserved in archaea
LN249_19445	COG0189	ligase activity
LN249_19455	COG3111	PFAM Bacterial OB fold (BOF) protein
LN249_19465	COG0725	ABC transporter, periplasmic molybdate-binding protein
LN249_19470	COG4149	molybdate abc transporter
LN249_19475	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LN249_19485	COG2203	Gaf domain
LN249_19485	COG5001	Diguanylate cyclase
LN249_19485	COG4251	negative regulation of phosphorylation
LN249_19485	COG3706	GGDEF domain
LN249_19510	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LN249_19665	COG1802	Transcriptional regulator
LN249_19665	COG4626	Terminase
LN249_19805	COG3140	Belongs to the UPF0181 family
LN249_19810	COG0589	response to stress
LN249_19820	COG0583	DNA-binding transcription factor activity
LN249_19915	COG0023	Translation Initiation Factor
LN249_19925	COG1181	Belongs to the D-alanine--D-alanine ligase family
LN249_19935	COG0045	succinate-CoA ligase (ADP-forming) activity
LN249_19935	COG1042	CoA-binding domain protein
LN249_19935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LN249_19940	COG0583	DNA-binding transcription factor activity
LN249_19950	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LN249_19955	COG5001	Diguanylate cyclase
LN249_19955	COG3447	MASE1 domain protein
LN249_19955	COG5002	protein histidine kinase activity
LN249_19960	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LN249_19965	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LN249_19970	COG1984	allophanate hydrolase subunit 2
LN249_19980	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LN249_19985	COG4181	ATPase activity
LN249_19995	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LN249_20000	COG5001	Diguanylate cyclase
LN249_20000	COG1716	ATPase activity
LN249_20035	COG4533	DNA binding
LN249_20045	COG2050	protein possibly involved in aromatic compounds catabolism
LN249_20060	COG2067	long-chain fatty acid transport protein
LN249_20065	COG2267	carboxylic ester hydrolase activity
LN249_20090	COG0737	Belongs to the 5'-nucleotidase family
LN249_20095	COG3593	DNA synthesis involved in DNA repair
LN249_20105	COG0583	DNA-binding transcription factor activity
LN249_20110	COG2116	formate transmembrane transporter activity
LN249_20115	COG2353	YceI-like domain
LN249_20120	COG3038	cytochrome b561
LN249_20135	COG4943	cyclic-guanylate-specific phosphodiesterase activity
LN249_20140	COG0513	Belongs to the DEAD box helicase family
LN249_20155	COG0546	phosphoglycolate phosphatase activity
LN249_20170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LN249_20175	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LN249_20180	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LN249_20190	COG2207	Transcriptional regulator
LN249_20195	COG1979	alcohol dehydrogenase
LN249_20205	COG1126	abc transporter atp-binding protein
LN249_20210	COG0765	amino acid transport
LN249_20215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LN249_20220	COG0765	amino acid transport
LN249_20225	COG2199	diguanylate cyclase activity
LN249_20225	COG2200	EAL domain
LN249_20225	COG2203	Gaf domain
LN249_20240	COG1609	Transcriptional regulator
LN249_20245	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LN249_20245	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LN249_20250	COG1105	Belongs to the carbohydrate kinase PfkB family
LN249_20255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LN249_20255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LN249_20255	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
LN249_20275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LN249_20285	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LN249_20295	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LN249_20300	COG0509	glycine decarboxylation via glycine cleavage system
LN249_20305	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LN249_20305	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LN249_20335	COG2176	DNA-directed DNA polymerase activity
LN249_20375	COG0242	peptide deformylase activity
LN249_20415	COG2239	Acts as a magnesium transporter
LN249_20435	COG0346	lactoylglutathione lyase activity
LN249_20440	COG1902	pentaerythritol trinitrate reductase activity
LN249_20460	COG5642	Protein of unknown function (DUF2384)
LN249_20465	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LN249_20525	COG2962	Rard protein
LN249_20540	COG0835	chemotaxis
LN249_20540	COG0784	Response regulator, receiver
LN249_20545	COG2197	response regulator
LN249_20615	COG4964	Belongs to the GSP D family
LN249_20640	COG2207	Transcriptional regulator
LN249_20670	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LN249_20690	COG1214	PFAM Peptidase M22, glycoprotease
LN249_20690	COG0456	acetyltransferase
LN249_20700	COG3069	C4-dicarboxylate transmembrane transporter activity
LN249_20705	COG1704	LemA family
LN249_20710	COG0501	Belongs to the peptidase M48B family
LN249_20735	COG3111	PFAM Bacterial OB fold (BOF) protein
LN249_20740	COG1597	lipid kinase activity
LN249_20745	COG0583	DNA-binding transcription factor activity
LN249_20750	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LN249_20750	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LN249_20780	COG0714	Associated with various cellular activities
LN249_20785	COG0641	radical SAM
LN249_20790	COG3119	arylsulfatase activity
LN249_20800	COG3119	arylsulfatase activity
LN249_20820	COG2198	Histidine kinase
LN249_20820	COG0784	Response regulator, receiver
LN249_20820	COG2205	protein histidine kinase activity
LN249_20825	COG1879	ABC-type sugar transport system periplasmic component
LN249_20830	COG1803	Methylglyoxal synthase
LN249_20835	COG0210	DNA helicase
LN249_20840	COG1289	transmembrane transporter activity
LN249_20870	COG1629	transport
LN249_20870	COG4771	TonB-dependent receptor
LN249_20875	COG2207	Transcriptional regulator
LN249_20880	COG0789	Transcriptional regulator
LN249_20885	COG4604	ABC transporter, ATP-binding protein
LN249_20890	COG4605	iron ion homeostasis
LN249_20895	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LN249_20900	COG4607	ABC-type enterochelin transport system periplasmic component
LN249_20920	COG1609	Transcriptional regulator
LN249_20925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LN249_20930	COG1879	ABC-type sugar transport system periplasmic component
LN249_20935	COG1172	Belongs to the binding-protein-dependent transport system permease family
LN249_20940	COG1129	ABC transporter
LN249_20945	COG1869	D-ribose catabolic process
LN249_20950	COG5001	Diguanylate cyclase
LN249_20995	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LN249_21005	COG0784	Response regulator, receiver
LN249_21005	COG2205	protein histidine kinase activity
LN249_21015	COG3300	MHYT domain
LN249_21015	COG5001	Diguanylate cyclase
LN249_21025	COG0330	HflC and HflK could
LN249_21040	COG4175	Glycine betaine
LN249_21040	COG0517	IMP dehydrogenase activity
LN249_21045	COG4176	ABC-type proline glycine betaine transport system permease component
LN249_21060	COG1012	belongs to the aldehyde dehydrogenase family
LN249_21065	COG1309	transcriptional regulator
LN249_21075	COG1028	Short-chain dehydrogenase reductase Sdr
LN249_21090	COG1024	Enoyl-CoA hydratase
LN249_21095	COG1960	acyl-CoA dehydrogenase activity
LN249_21105	COG0183	Belongs to the thiolase family
LN249_21115	COG1960	acyl-CoA dehydrogenase activity
LN249_21120	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LN249_21130	COG4770	biotin carboxylase activity
LN249_21140	COG2205	protein histidine kinase activity
LN249_21140	COG3850	Histidine kinase
LN249_21140	COG4999	Histidine kinase
LN249_21140	COG3437	response regulator, receiver
LN249_21155	COG0110	maltose O-acetyltransferase activity
LN249_21160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LN249_21165	COG1271	oxidase subunit
LN249_21170	COG1294	oxidase, subunit
LN249_21180	COG0384	phenazine biosynthesis protein PhzF
LN249_21185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LN249_21195	COG3527	Alpha-acetolactate decarboxylase
LN249_21210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LN249_21270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LN249_21275	COG1320	monovalent cation:proton antiporter activity
LN249_21280	COG2212	antiporter activity
LN249_21285	COG1863	multisubunit Na H antiporter MnhE subunit
LN249_21290	COG0651	ATP synthesis coupled electron transport
LN249_21295	COG1006	Multisubunit Na H antiporter MnhC subunit
LN249_21300	COG2111	Na H antiporter
LN249_21300	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LN249_21310	COG0589	response to stress
LN249_21315	COG4221	oxidoreductase activity
LN249_21320	COG0583	DNA-binding transcription factor activity
LN249_21330	COG2814	Major facilitator Superfamily
LN249_21350	COG3179	chitinase
LN249_21395	COG1522	sequence-specific DNA binding
LN249_21430	COG0515	serine threonine protein kinase
LN249_21455	COG3501	Rhs element vgr protein
LN249_21500	COG0739	heme binding
LN249_21505	COG0583	DNA-binding transcription factor activity
LN249_21510	COG0674	pyruvate-flavodoxin oxidoreductase activity
LN249_21510	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LN249_21515	COG1013	pyruvate-flavodoxin oxidoreductase activity
LN249_21530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LN249_21580	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
LN249_21590	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LN249_21590	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LN249_21605	COG4989	oxidoreductase activity
LN249_21620	COG0038	chloride channel
LN249_21630	COG1914	H( )-stimulated, divalent metal cation uptake system
LN249_21645	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LN249_21665	COG2897	thiosulfate sulfurtransferase activity
LN249_21685	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LN249_21690	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LN249_21695	COG0840	transmembrane signaling receptor activity
LN249_21700	COG2814	Major facilitator Superfamily
LN249_21705	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LN249_21715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LN249_21725	COG0840	transmembrane signaling receptor activity
LN249_21745	COG2195	Cleaves the N-terminal amino acid of tripeptides
LN249_21760	COG2197	response regulator
LN249_21765	COG3850	Histidine kinase
LN249_21770	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LN249_21780	COG0243	molybdopterin cofactor binding
LN249_21790	COG3005	denitrification pathway
LN249_21800	COG3243	poly(R)-hydroxyalkanoic acid synthase
LN249_21810	COG0183	Belongs to the thiolase family
LN249_21820	COG1280	lysine exporter protein (LysE YggA)
LN249_21830	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LN249_21835	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LN249_21890	COG2205	protein histidine kinase activity
LN249_21890	COG0784	Response regulator, receiver
LN249_21895	COG1879	ABC-type sugar transport system periplasmic component
LN249_21900	COG2827	Endonuclease containing a URI domain
LN249_21905	COG3132	Protein of unknown function, DUF480
LN249_21925	COG0784	Response regulator, receiver
LN249_21925	COG5002	protein histidine kinase activity
LN249_21925	COG2205	protein histidine kinase activity
LN249_21945	COG0583	DNA-binding transcription factor activity
LN249_21955	COG0531	amino acid
LN249_21970	COG2205	protein histidine kinase activity
LN249_21975	COG0745	RESPONSE REGULATOR receiver
LN249_22005	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LN249_22010	COG2239	Acts as a magnesium transporter
LN249_22015	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LN249_22020	COG0402	S-adenosylhomocysteine deaminase activity
LN249_22025	COG1418	mRNA catabolic process
LN249_22035	COG2814	Major facilitator Superfamily
LN249_22045	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LN249_22060	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LN249_22075	COG0745	RESPONSE REGULATOR receiver
LN249_22080	COG2205	protein histidine kinase activity
LN249_22090	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LN249_22095	COG2194	sulfuric ester hydrolase activity
LN249_22115	COG4667	esterase of the alpha-beta hydrolase superfamily
LN249_22120	COG1741	Belongs to the pirin family
LN249_22125	COG1278	Cold shock
LN249_22140	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LN249_22145	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LN249_22145	COG0678	peroxiredoxin activity
LN249_22155	COG1686	Belongs to the peptidase S11 family
LN249_22160	COG0625	glutathione transferase activity
LN249_22165	COG1621	beta-fructofuranosidase activity
LN249_22170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LN249_22175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LN249_22175	COG1263	PTS System
LN249_22195	COG1028	Short-chain dehydrogenase reductase Sdr
LN249_22210	COG3746	phosphate-selective porin O and P
LN249_22230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LN249_22230	COG2207	Transcriptional regulator
LN249_22235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LN249_22270	COG0513	Belongs to the DEAD box helicase family
LN249_22280	COG0583	DNA-binding transcription factor activity
LN249_22295	COG1902	pentaerythritol trinitrate reductase activity
LN249_22300	COG1063	alcohol dehydrogenase
LN249_22310	COG1028	Short-chain dehydrogenase reductase Sdr
LN249_22315	COG2207	Transcriptional regulator
LN249_22320	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LN249_22325	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LN249_22330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LN249_22335	COG0006	proline dipeptidase activity
LN249_22340	COG3608	succinylglutamate desuccinylase aspartoacylase
LN249_22345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LN249_22350	COG1522	sequence-specific DNA binding
LN249_22355	COG1012	belongs to the aldehyde dehydrogenase family
LN249_22360	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LN249_22365	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LN249_22370	COG2423	ornithine cyclodeaminase activity
LN249_22380	COG3122	Protein conserved in bacteria
LN249_22385	COG1280	lysine exporter protein (LysE YggA)
LN249_22395	COG0583	DNA-binding transcription factor activity
LN249_22400	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LN249_22405	COG0252	asparaginase activity
LN249_22410	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LN249_22425	COG2197	response regulator
LN249_22430	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LN249_22445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LN249_22470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LN249_22500	COG3842	ATPase activity
LN249_22535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LN249_22570	COG0583	DNA-binding transcription factor activity
LN249_22580	COG4948	Mandelate Racemase Muconate Lactonizing
LN249_22585	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LN249_22610	COG1342	Belongs to the UPF0251 family
LN249_22615	COG4176	ABC-type proline glycine betaine transport system permease component
LN249_22620	COG3448	diguanylate cyclase activity
LN249_22620	COG4175	Glycine betaine
LN249_22625	COG3015	lipoprotein NlpE involved in copper resistance
LN249_22645	COG0583	DNA-binding transcription factor activity
LN249_22670	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LN249_22680	COG1335	isochorismatase
LN249_22690	COG1349	DNA-binding transcription factor activity
LN249_22695	COG0346	lactoylglutathione lyase activity
LN249_22715	COG2070	2-Nitropropane dioxygenase
LN249_22720	COG0531	amino acid
LN249_22725	COG4302	ethanolamine ammonia-lyase activity
LN249_22730	COG4303	Ethanolamine ammonia lyase large subunit
LN249_22735	COG2207	Transcriptional regulator
LN249_22740	COG1309	transcriptional regulator
LN249_22770	COG0459	protein refolding
LN249_22775	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LN249_22780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LN249_22795	COG1304	FMN binding
LN249_22815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LN249_22820	COG4786	Flagellar basal body rod
LN249_22820	COG1256	bacterial-type flagellum assembly
LN249_22830	COG1706	bacterial-type flagellum-dependent cell motility
LN249_22835	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LN249_22840	COG4786	Flagellar basal body rod
LN249_22845	COG4787	bacterial-type flagellum-dependent cell motility
LN249_22850	COG1749	Flagellar hook protein flgE
LN249_22855	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LN249_22860	COG1558	bacterial-type flagellum-dependent cell motility
LN249_22865	COG1815	bacterial-type flagellum-dependent cell motility
LN249_22885	COG0741	lytic transglycosylase activity
LN249_22890	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LN249_22910	COG1760	l-serine dehydratase
LN249_22915	COG3104	oligopeptide transport
LN249_22935	COG0583	DNA-binding transcription factor activity
LN249_22945	COG2866	Carboxypeptidase
LN249_22950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LN249_22960	COG2990	Protein conserved in bacteria
LN249_22985	COG3842	ATPase activity
LN249_22990	COG1840	ABC-type Fe3 transport system, periplasmic component
LN249_23000	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LN249_23005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LN249_23010	COG1609	Transcriptional regulator
LN249_23040	COG3240	lipase activity
LN249_23045	COG2067	long-chain fatty acid transport protein
LN249_23055	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
LN249_23070	COG1011	Hydrolase
LN249_23075	COG0583	DNA-binding transcription factor activity
LN249_23105	COG0110	maltose O-acetyltransferase activity
LN249_23110	COG1765	OsmC-like protein
LN249_23115	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LN249_23115	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LN249_23130	COG3046	protein related to deoxyribodipyrimidine photolyase
LN249_23135	COG0415	Belongs to the DNA photolyase family
LN249_23140	COG3706	GGDEF domain
LN249_23155	COG3706	GGDEF domain
LN249_23170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LN249_23185	COG3033	Beta-eliminating lyase
LN249_23195	COG1271	oxidase subunit
LN249_23200	COG1294	oxidase, subunit
LN249_23210	COG0579	oxidoreductase
LN249_23225	COG1114	Component of the transport system for branched-chain amino acids
LN249_23230	COG3706	GGDEF domain
LN249_23235	COG2204	response regulator
LN249_23240	COG4191	Histidine kinase
LN249_23275	COG0583	DNA-binding transcription factor activity
LN249_23280	COG0189	ligase activity
LN249_23285	COG0189	ligase activity
LN249_23285	COG4067	protein conserved in archaea
LN249_23295	COG1166	arginine decarboxylase activity
LN249_23300	COG0010	Belongs to the arginase family
LN249_23305	COG2814	Major facilitator Superfamily
LN249_23310	COG1770	oligopeptidase
LN249_23325	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LN249_23330	COG1121	(ABC) transporter
LN249_23335	COG0803	Belongs to the bacterial solute-binding protein 9 family
LN249_23375	COG0848	biopolymer transport protein
LN249_23380	COG0811	peptide transport
LN249_23385	COG0811	peptide transport
LN249_23405	COG0745	RESPONSE REGULATOR receiver
LN249_23410	COG0039	L-malate dehydrogenase activity
LN249_23415	COG0584	glycerophosphoryl diester phosphodiesterase
LN249_23425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LN249_23485	COG1901	pseudouridine methyltransferase
LN249_23490	COG0312	modulator of DNA gyrase
LN249_23495	COG0312	modulator of DNA gyrase
LN249_23500	COG0351	phosphomethylpyrimidine kinase
LN249_23505	COG1116	anion transmembrane transporter activity
LN249_23510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LN249_23515	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LN249_23520	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LN249_23525	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
LN249_23530	COG0352	thiamine-phosphate diphosphorylase activity
LN249_23540	COG0243	molybdopterin cofactor binding
LN249_23545	COG3005	denitrification pathway
LN249_23550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LN249_23555	COG1028	Short-chain dehydrogenase reductase Sdr
LN249_23570	COG0456	acetyltransferase
LN249_23590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LN249_23595	COG1929	Belongs to the glycerate kinase type-1 family
LN249_23600	COG2610	gluconate transmembrane transporter activity
LN249_23605	COG3835	regulator
LN249_23645	COG0583	DNA-binding transcription factor activity
LN249_23655	COG0583	DNA-binding transcription factor activity
LN249_23665	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LN249_23670	COG3408	Glycogen debranching enzyme
LN249_23670	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
LN249_23700	COG3047	cAMP biosynthetic process
LN249_23705	COG1357	PFAM Pentapeptide repeats (8 copies)
LN249_23745	COG0823	Involved in the tonB-independent uptake of proteins
LN249_23750	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LN249_23770	COG0800	Aldolase
LN249_23775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LN249_23790	COG1917	Cupin 2, conserved barrel domain protein
LN249_23800	COG1028	Short-chain dehydrogenase reductase Sdr
LN249_23805	COG1414	Transcriptional regulator
LN249_23820	COG0583	DNA-binding transcription factor activity
LN249_23825	COG2162	N-hydroxyarylamine O-acetyltransferase activity
LN249_23830	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LN249_23845	COG2199	diguanylate cyclase activity
LN249_23855	COG0561	phosphatase activity
LN249_23860	COG0583	DNA-binding transcription factor activity
LN249_23875	COG0564	pseudouridine synthase activity
LN249_23880	COG0534	Mate efflux family protein
LN249_23895	COG3123	guanosine phosphorylase activity
LN249_24205	COG2356	endonuclease I
LN249_24245	COG1192	Involved in chromosome partitioning
LN249_24330	COG0484	heat shock protein binding