locus-tag class description N646_0001 ENOG4105E4F Isochorismate synthase N646_0002 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) N646_0005 ENOG4108IPT Naphthoate synthase N646_0006 ENOG4105DNI Converts SHCHC to OSB (By similarity) N646_0007 ENOG4105CEY Amp-dependent synthetase and ligase N646_0009 ENOG4105HMI Membrane N646_0010 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) N646_0014 ENOG4105EP1 Efflux transporter rnd family, mfp subunit N646_0015 ENOG4105BZS acriflavin resistance protein N646_0018 ENOG4105C6T cysteine synthase N646_0019 ENOG4108XM1 transcriptional regulator AsnC family N646_0021 ENOG4105C29 acyl-CoA thioesterase N646_0022 ENOG4108MNP Glycoprotein polysaccharide metabolism N646_0025 ENOG4105BZU Histidine kinase N646_0027 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) N646_0029 ENOG4107SXA Phosphorylase N646_0031 ENOG4108NVR Methyl-accepting chemotaxis N646_0032 ENOG4105K59 histidine triad (HIT) protein N646_0037 ENOG4105D0Y UPF0227 protein N646_0038 ENOG4105CEP NADH dehydrogenase N646_0041 ENOG4108JA2 transcriptioN-repair coupling factor N646_0043 ENOG4105D60 lipoprotein releasing system transmembrane protein N646_0044 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) N646_0045 ENOG4105D60 lipoprotein releasing system transmembrane protein N646_0047 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 N646_0048 ENOG4105BZ1 (ABC) transporter N646_0049 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) N646_0050 ENOG4105W49 UPF0434 protein N646_0051 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) N646_0052 ENOG4105ED1 spovr family N646_0053 ENOG4106AKX UPF0229 protein N646_0054 ENOG4105CYN Serine protein kinase N646_0055 ENOG4105XWI UPF0304 protein N646_0057 ENOG4105F1A Pyruvate formate-lyase N646_0059 ENOG4105C6N Formate acetyltransferase N646_0062 ENOG4108JEH abc transporter atp-binding protein N646_0063 ENOG4105E89 ABC transporter N646_0065 ENOG4105DSP amino acid AbC transporter N646_0068 ENOG4105CGK Exodeoxyribonuclease III N646_0069 ENOG4106428 Protein of unknown function (DUF2496) N646_0070 ENOG4108URS primosomal replication protein n'' N646_0071 ENOG4105EJ9 Membrane N646_0072 ENOG4105DVT helicase N646_0073 ENOG4105SDR Outer membrane protein OmpT N646_0075 ENOG4108R99 pseudouridine synthase N646_0077 ENOG4105VEQ Cold shock protein N646_0078 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) N646_0079 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit N646_0080 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) N646_0081 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate N646_0082 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) N646_0084 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase N646_0085 ENOG4105RKX Protein of unknown function (DUF2498) N646_0087 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) N646_0088 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) N646_0089 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) N646_0093 ENOG4105HP8 regulator of competence-specific genes N646_0094 ENOG4105ETE Transcriptional regulator (LacI family N646_0095 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) N646_0096 ENOG4106WF9 DNA-binding transcriptional regulator TorR N646_0097 ENOG4107S90 membrAne N646_0098 ENOG4106371 Methyltransferase N646_0099 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) N646_0100 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) N646_0101 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) N646_0105 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) N646_0106 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) N646_0107 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) N646_0108 ENOG41081XQ Conserved Protein N646_0109 ENOG4105C9M aspartyl-trna synthetase N646_0110 ENOG4105CDY transcriptional regulatory protein N646_0111 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) N646_0112 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) N646_0113 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) N646_0114 ENOG4105C4M (Ubiquinol oxidase) subunit I N646_0115 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii N646_0117 ENOG4107YD3 Thioesterase N646_0118 ENOG4105E02 MotA TolQ exbB proton channel N646_0119 ENOG4105M8F Biopolymer transport protein exbD tolR N646_0121 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) N646_0122 ENOG4105KCK Peptidoglycan-associated lipoprotein N646_0123 ENOG4105UFD tol-pal system protein YbgF N646_0124 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) N646_0126 ENOG4105Z6B inner membrane protein yjfl N646_0128 ENOG4106032 Glutathionylspermidine synthase N646_0130 ENOG4105BZU Histidine kinase N646_0131 ENOG4108RNS Exports L-alanine (By similarity) N646_0136 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii N646_0137 ENOG4105C4M (Ubiquinol oxidase) subunit I N646_0139 ENOG4105C8Q Methyl-accepting chemotaxis N646_0140 ENOG4105C1P efflux transporter, rnd family, mfp subunit N646_0141 ENOG4105BZS acriflavin resistance protein N646_0150 ENOG4108NVR Methyl-accepting chemotaxis N646_0151 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase N646_0154 ENOG4107R11 Transcriptional regulator N646_0156 ENOG4105DCF alanine dehydrogenase N646_0157 ENOG4105EW9 transcriptional regulator AsnC family N646_0158 ENOG4105CNU cell division protein FtsK N646_0159 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) N646_0160 ENOG4105D1H recombination factor protein RarA N646_0161 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) N646_0162 ENOG4105KSC Transcriptional regulator, TraR DksA family N646_0164 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) N646_0165 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) N646_0167 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) N646_0169 ENOG4105D0M Protease HtpX homolog N646_0171 ENOG4107FW0 short-chain dehydrogenase reductase N646_0174 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase N646_0176 ENOG4105RHG N646_0178 ENOG4107QTF adenylosuccinate lyase N646_0179 ENOG41075W9 High frequency lysogenization protein HflD homolog N646_0180 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) N646_0182 ENOG4107RE1 Inosine-guanosine kinase N646_0183 ENOG4108YX2 DNA-binding protein N646_0184 ENOG4107S6Z Na H antiporter N646_0185 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family N646_0186 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) N646_0187 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) N646_0188 ENOG4105CIH Imidazole acetol-phosphate transaminase N646_0190 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) N646_0194 ENOG4105K5B UPF0225 protein N646_0195 ENOG4105D58 Diguanylate phosphodiesterase N646_0196 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) N646_0197 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) N646_0198 ENOG4105C8N cysteinyl-tRNA synthetase N646_0199 ENOG4107104 thymidine kinase N646_0205 ENOG4105TMB Formate nitrite transporter N646_0210 ENOG4108J2R molybdopterin oxidoreductase N646_0213 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase N646_0215 ENOG4108JQ2 peptide transport system atp-binding protein N646_0216 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein N646_0217 ENOG4108EU3 peptide transport system, permease N646_0218 ENOG4108I5W peptide transport system, permease protein N646_0219 ENOG4108J59 Extracellular solute-binding protein, family 5 N646_0220 ENOG4105E51 psp operon transcriptional activator N646_0221 ENOG41087YS Phage shock protein A N646_0222 ENOG4105YYT phage shock protein B N646_0223 ENOG4105FM1 phage shock protein C N646_0227 ENOG4108R3E Dna-3-methyladenine glycosylase i N646_0229 ENOG4107IFA Lipase (EC 3.1.1.3) N646_0230 ENOG4105C28 cystathionine N646_0231 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) N646_0232 ENOG4105C8J )-transporter N646_0233 ENOG4108W1A pseudouridine synthase N646_0234 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) N646_0235 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) N646_0236 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) N646_0237 ENOG4108JUA Transcriptional regulator N646_0239 ENOG4108T9J Cdp-alcohol phosphatidyltransferase N646_0240 ENOG4108VGW abc transporter atp-binding protein N646_0241 ENOG4105CXZ ABC transporter, permease N646_0242 ENOG4105VNH ABC transporter solute-binding protein N646_0246 ENOG4105CGH 5'-nucleotidase N646_0249 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) N646_0250 ENOG4105EB3 Histidine kinase N646_0251 ENOG4105ETX regulatoR N646_0253 ENOG4105CFI type iii restriction protein res subunit N646_0254 ENOG4105I08 Pseudouridine synthase N646_0256 ENOG4105C2C drug resistance transporter, Bcr CflA N646_0258 ENOG4105CGD Nad-dependent epimerase dehydratase N646_0259 ENOG4107QI1 Mate efflux family protein N646_0263 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) N646_0265 ENOG41067SE Tetr family transcriptional regulator N646_0266 ENOG4107QPN acyl-Coa dehydrogenase N646_0267 ENOG4105RKW reductase (By N646_0268 ENOG4105D0C transport protein N646_0269 ENOG41090BQ Glutaredoxin N646_0271 ENOG4106KNT transcriptional regulator N646_0272 ENOG4105DY8 decarboxylase N646_0275 ENOG4105DWU Membrane N646_0282 ENOG4105BZU Histidine kinase N646_0284 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) N646_0285 ENOG4105BZC d-serine deaminase N646_0286 ENOG4108JJ8 (ABC) transporter N646_0287 ENOG4108JJ9 ABC, transporter N646_0288 ENOG4105C3M thioredoxin reductase N646_0292 ENOG4105BZU Histidine kinase N646_0294 ENOG4105C8P )-transporter N646_0295 ENOG4107GZ4 SanA protein N646_0296 ENOG4107R1I NAD-dependent malic enzyme N646_0297 ENOG4105CQ7 ATP-dependent helicase N646_0300 ENOG4105C8V SAICAR synthetase N646_0304 ENOG4105CDV Ompa motb domain protein N646_0307 ENOG4105CQB FAD linked oxidase domain protein N646_0310 ENOG4105C84 Histidine ammonia-lyase N646_0312 ENOG41088SP formiminoglutamate hydrolase N646_0313 ENOG4105CI2 imidazolone-5-propionate hydrolase N646_0314 ENOG4105CZE histidine utilization repressor N646_0317 ENOG4105C22 threonyL-tRNA synthetase N646_0318 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) N646_0319 ENOG41082NX 50s ribosomal protein l35 N646_0320 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) N646_0321 ENOG4105K8R UPF0145 protein N646_0328 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) N646_0329 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) N646_0331 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) N646_0333 ENOG4105FQ6 thiopurine methyltransferase N646_0334 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR N646_0335 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) N646_0336 ENOG41067MG lrgb family N646_0337 ENOG4105VAW lrga family N646_0338 ENOG4105CJB Exodeoxyribonuclease I N646_0340 ENOG4108ETY sodium dicarboxylate symporter N646_0341 ENOG4105K4T epimerase N646_0342 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) N646_0343 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) N646_0344 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) N646_0348 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) N646_0349 ENOG4108IU2 vtamin B12-transporter permease N646_0350 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) N646_0354 ENOG4105F04 LysR family Transcriptional regulator N646_0356 ENOG4108VKG metal-dependent hydrolase N646_0357 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) N646_0364 ENOG4105CTU Proline racemase N646_0368 ENOG4105CIF Ornithine Cyclodeaminase N646_0369 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) N646_0370 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) N646_0371 ENOG4105F38 ABC transporter, permease N646_0372 ENOG4105D38 putrescine abc transporter N646_0375 ENOG4107MM9 BNR Asp-box repeat-containing protein N646_0377 ENOG4108JQ7 (ABC) transporter N646_0378 ENOG4105C3U ABC transporter N646_0379 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component N646_0380 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component N646_0381 ENOG4107QSI ABC, transporter N646_0382 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) N646_0383 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase N646_0384 ENOG4105F1J Homogentisate 1,2-dioxygenase N646_0386 ENOG4108RXX maleylacetoacetate isomerase N646_0394 ENOG4105VTN Protein of unknown function (DUF1311) N646_0401 ENOG4107S6Z Na H antiporter N646_0402 ENOG4105CFQ glutamine synthetase N646_0403 ENOG4108Z86 Glutamine amidotransferase N646_0404 ENOG4107VRI Transcriptional regulator N646_0405 ENOG4105C26 Dehydrogenase N646_0406 ENOG4105CJP fad dependent oxidoreductase N646_0408 ENOG4105DWY Agmatine deiminase N646_0409 ENOG4105C26 Dehydrogenase N646_0410 ENOG4108JPW Aminotransferase N646_0411 ENOG4105BZU Histidine kinase N646_0413 ENOG4108ZT1 Transcriptional regulator N646_0414 ENOG4105MSB protein, conserved in bacteria N646_0419 ENOG4105BZU Histidine kinase N646_0420 ENOG4105BZU Histidine kinase N646_0422 ENOG41090FY type IV pilus biogenesis stability protein PilW N646_0423 ENOG4105CVG Homoserine O-transsuccinylase N646_0426 ENOG4105D1S lipid A biosynthesis N646_0427 ENOG4105CTD carboxy-peptidase N646_0428 ENOG410829K Lysine exporter protein (Lyse ygga) N646_0430 ENOG4105BZG amino acid carrier protein N646_0435 ENOG4105E0M Sulfatase N646_0436 ENOG4105GIJ Glycine betaine N646_0437 ENOG4108HQS Glycine betaine N646_0438 ENOG4108IJ7 Glycine betaine N646_0441 ENOG4105C94 Transporter N646_0442 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase N646_0443 ENOG4108JPW Aminotransferase N646_0444 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) N646_0445 ENOG4105CZK Aspartate kinase N646_0446 ENOG4108RS6 transposase N646_0447 ENOG4105ENH Sulfatase N646_0450 ENOG4105C4X radical SAM domain protein N646_0453 ENOG4105ENH Sulfatase N646_0455 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) N646_0459 ENOG4108JJA ABC, transporter N646_0461 ENOG4105DFG type I secretion outer membrane protein N646_0464 ENOG4105E98 transcriptional regulator DeoR family N646_0465 ENOG4105D9R oxidoreductase N646_0466 ENOG41090KN UPF0303 protein N646_0467 ENOG4105BZU Histidine kinase N646_0470 ENOG4105C8P )-transporter N646_0472 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family N646_0473 ENOG4105BZU Histidine kinase N646_0474 ENOG4105CPI Metal Dependent Phosphohydrolase N646_0475 ENOG410829K Lysine exporter protein (Lyse ygga) N646_0476 ENOG4105G0K glycine radical enzyme YjjI family N646_0477 ENOG41076CZ activating enzyme N646_0479 ENOG4105EE5 Membrane protein terC N646_0481 ENOG4105DHT Metal Dependent Phosphohydrolase N646_0483 ENOG4105E0U tyrosine-specific transport protein N646_0484 ENOG4105CPI Metal Dependent Phosphohydrolase N646_0486 ENOG4105E0A ABC, transporter N646_0487 ENOG4105J76 Periplasmic binding protein N646_0488 ENOG4105S6R Iron-hydroxamate transporter permease subunit N646_0489 ENOG4105E0K tonB-dependent siderophore receptor N646_0491 ENOG4105BZ1 (ABC) transporter N646_0492 ENOG4105BZ1 (ABC) transporter N646_0493 ENOG4108VAU general secretion pathway protein G N646_0495 ENOG4105CR8 Transcriptional regulator N646_0500 ENOG4105CFG Acts as a chaperone (By similarity) N646_0501 ENOG4105CFG Acts as a chaperone (By similarity) N646_0512 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) N646_0513 ENOG4105CQ7 ATP-dependent helicase N646_0516 ENOG4105C94 Transporter N646_0519 ENOG4107R8N Glycosyl transferase, family 2 N646_0520 ENOG4105CPK Glycosyl transferase (Group 1 N646_0526 ENOG4107TYR Glycosyl Transferase N646_0527 ENOG4107QPH glycogen) synthase N646_0528 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family N646_0531 ENOG4107V1M polysaccharide export protein N646_0533 ENOG41082AN stage II sporulation protein N646_0536 ENOG4107QI1 Mate efflux family protein N646_0537 ENOG4108R6K riboflavin synthase, subunit alpha N646_0539 ENOG4105FGM Fructosamine kinase N646_0541 ENOG4105BZU Histidine kinase N646_0543 ENOG4107TT5 NLP P60 protein N646_0550 ENOG4106IUH DTW domain containing protein N646_0551 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) N646_0553 ENOG4105CVM Molybdenum cofactor synthesis domain protein N646_0554 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) N646_0555 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) N646_0558 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family N646_0559 ENOG4105BZU Histidine kinase N646_0560 ENOG4105C5H ABC transporter N646_0561 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) N646_0565 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) N646_0567 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) N646_0568 ENOG4105QAX Iron-sulfur N646_0574 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) N646_0575 ENOG4107RUE extracellular solute-binding protein family 1 N646_0576 ENOG4107RUE extracellular solute-binding protein family 1 N646_0577 ENOG4105D38 putrescine abc transporter N646_0578 ENOG4105F38 ABC transporter, permease N646_0579 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) N646_0583 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) N646_0584 ENOG4108RS6 transposase N646_0585 ENOG4105Q9Y Universal stress protein N646_0586 ENOG4105DS0 Transcriptional regulator, Crp Fnr family N646_0589 ENOG4105C59 p-type ATPase N646_0591 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) N646_0594 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i N646_0607 ENOG4105MQ5 zona occludens toxin N646_0616 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) N646_0618 ENOG4105DAN ATP-dependent protease N646_0619 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) N646_0622 ENOG4105C5H ABC transporter N646_0624 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) N646_0625 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) N646_0626 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) N646_0627 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) N646_0629 ENOG4105C7I Dehydrogenase N646_0630 ENOG4105CD8 aminopeptidase N N646_0632 ENOG4105CN1 protease N646_0633 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) N646_0634 ENOG4108ZGC gaf domain protein N646_0635 ENOG4105BZ1 (ABC) transporter N646_0636 ENOG4105H2K paraquat-inducible protein a N646_0637 ENOG4105DY2 Paraquat-inducible protein b N646_0638 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B N646_0642 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) N646_0643 ENOG4108VPT UPF0234 protein N646_0645 ENOG4107QXX ABC transporter N646_0647 ENOG4105EZ7 amino acid ABC transporter N646_0648 ENOG4105DRP amino acid AbC transporter N646_0649 ENOG4105CDA abc transporter atp-binding protein N646_0650 ENOG4108MN8 Membrane N646_0652 ENOG4108Z0T Part of a sulfur-relay system (By similarity) N646_0653 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 N646_0654 ENOG4105C8Q Methyl-accepting chemotaxis N646_0655 ENOG4105DR4 Methyltransferase N646_0667 ENOG4105KCK Peptidoglycan-associated lipoprotein N646_0670 ENOG4105CDV Ompa motb domain protein N646_0672 ENOG410620I Diguanylate cyclase N646_0674 ENOG4107HP6 Transcriptional regulator N646_0676 ENOG4105CV8 reductase N646_0677 ENOG4105HEI LysR family (Transcriptional regulator N646_0679 ENOG4105HEI LysR family (Transcriptional regulator N646_0680 ENOG4105F27 Major Facilitator N646_0682 ENOG4105EE1 crotonyl-CoA reductase N646_0683 ENOG41063TF transcriptional regulator (AraC N646_0684 ENOG4108W2Y isochorismatase N646_0685 ENOG4106PMH Extracellular solute-binding protein family 3 N646_0687 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein N646_0688 ENOG4105C3R Methionine synthase N646_0690 ENOG4105CDA abc transporter atp-binding protein N646_0691 ENOG4105EAD ABC transporter N646_0692 ENOG4106PMH Extracellular solute-binding protein family 3 N646_0695 ENOG4105CC0 LysR family Transcriptional regulator N646_0698 ENOG4105HEI LysR family (Transcriptional regulator N646_0700 ENOG41090KR LysR family transcriptional Regulator N646_0703 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) N646_0704 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) N646_0705 ENOG410667J hydrolase N646_0707 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap N646_0709 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) N646_0710 ENOG4105C7F AcnD-accessory protein PrpF N646_0711 ENOG4108I0Z Aconitate hydratase N646_0712 ENOG4105BZN citrate synthase N646_0713 ENOG4105CR4 methylisocitrate lyase N646_0720 ENOG4105EJ9 Membrane N646_0723 ENOG4108RS6 transposase N646_0744 ENOG4105E7U AraC family transcriptional regulator N646_0759 ENOG41066XE Type III export protein N646_0765 ENOG4108KB1 transcriptional regulator, arac family N646_0769 ENOG4105C26 Dehydrogenase N646_0770 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family N646_0773 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) N646_0774 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) N646_0775 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase N646_0778 ENOG4106YYS transcriptional regulatory protein N646_0779 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism N646_0781 ENOG4107KET secretion protein, HlyD family N646_0784 ENOG4105DUM transcriptional regulator, lysR family N646_0788 ENOG4105CEB Aspartate aminotransferase N646_0789 ENOG4105D0C transport protein N646_0792 ENOG4105Y49 secretion protein, HlyD family N646_0795 ENOG4105EBR Carboxylesterase N646_0796 ENOG4107RZC phospholipase d N646_0797 ENOG4105CFU surface antigen N646_0798 ENOG41090VV Protein of unknown function (DUF2846) N646_0799 ENOG4105N14 lysine exporter protein LysE YggA N646_0801 ENOG4105KCV RNA signal recognition particle 4.5S RNA N646_0804 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) N646_0805 ENOG41068WN N646_0806 ENOG4108UW5 maltose o-acetyltransferase N646_0820 ENOG4105E5W Transporter N646_0821 ENOG4108TSE Transferase N646_0823 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) N646_0824 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase N646_0825 ENOG4105E4F Isochorismate synthase N646_0826 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase N646_0827 ENOG4105WQI isochorismatase N646_0828 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein N646_0831 ENOG4105DQ5 transport system permease protein N646_0832 ENOG4105TVJ transport system, permease N646_0833 ENOG4105E0A ABC, transporter N646_0836 ENOG4105E93 esterase N646_0837 ENOG4107RBR Receptor N646_0841 ENOG4105IJJ transcriptional regulator, crp fnr family N646_0856 ENOG4108W0I acetyltransferase N646_0859 ENOG4108W0I acetyltransferase N646_0893 ENOG4105K4U addiction module toxin, RelE StbE family N646_0900 ENOG4107W31 Pentapeptide repeat protein N646_0930 ENOG4108K3A Glutathione S-transferase N646_0933 ENOG4105K4U addiction module toxin, RelE StbE family N646_0937 ENOG4105D3W isochorismatase N646_0947 ENOG4105K4U addiction module toxin, RelE StbE family N646_0956 ENOG4105D9U N-acetyltransferase N646_0958 ENOG4106K28 UPF0283 membrane protein N646_0959 ENOG4105CM6 amino acid regulated cytosolic protein N646_0962 ENOG4105CRQ synthase (Component I) N646_0965 ENOG4105P8F nudix hydrolase N646_0966 ENOG4105C44 Serine transporter N646_0967 ENOG4105EJQ L-serine dehydratase N646_0968 ENOG4105BZU Histidine kinase N646_0970 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase N646_0972 ENOG4105BZU Histidine kinase N646_0973 ENOG4105BZU Histidine kinase N646_0974 ENOG4105C8Q Methyl-accepting chemotaxis N646_0975 ENOG4105C5S asparaginyl-tRNA synthetase N646_0977 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family N646_0981 ENOG4105CGF Aromatic amino acid aminotransferase N646_0985 ENOG4105C8Q Methyl-accepting chemotaxis N646_0986 ENOG4105C94 Transporter N646_0990 ENOG4105CG6 trap dicarboxylate transporter dctm subunit N646_0992 ENOG4105CH5 extracellular solute-binding protein, family 7 N646_0995 ENOG4105C5X domain protein N646_0996 ENOG4105EAQ (twin-arginine translocation) pathway signal N646_0997 ENOG4105DIT ErfK YbiS YcfS YnhG family protein N646_1002 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) N646_1004 ENOG4108DMF Cytochrome C biogenesis protein N646_1005 ENOG4107QX9 Thiol disulfide interChange protein N646_1006 ENOG4105DA4 cytochrome c-type biogenesis protein N646_1007 ENOG4105DVI reductase, NrfD N646_1008 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein N646_1010 ENOG4105EAU Plays a role in nitrite reduction (By similarity) N646_1013 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) N646_1014 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) N646_1016 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) N646_1017 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) N646_1022 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) N646_1027 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) N646_1028 ENOG4105WH1 Two component transcriptional regulator luxr family N646_1029 ENOG4105CQ2 DNA polymerase N646_1032 ENOG4108W5H UPF0263 protein N646_1033 ENOG4105FE9 pseudouridine synthase N646_1035 ENOG4107RTD sua5 ycio yrdc ywlc family protein N646_1036 ENOG4105DB7 PHP domain protein N646_1038 ENOG4105CRQ synthase (Component I) N646_1039 ENOG4105DDQ anthranilate synthase N646_1040 ENOG4108I0Q anthranilate phosphoribosyltransferase N646_1041 ENOG4105DK0 Indole-3-glycerol phosphate synthase N646_1042 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) N646_1043 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) N646_1044 ENOG4105DS0 Transcriptional regulator, Crp Fnr family N646_1045 ENOG4105CEY Amp-dependent synthetase and ligase N646_1047 ENOG4105CK2 sodium dicarboxylate symporter N646_1049 ENOG4105BZU Histidine kinase N646_1051 ENOG4107835 probably involved in intracellular septation (By similarity) N646_1052 ENOG4105NAU thioesterase Superfamily protein N646_1053 ENOG4105K9H YciI-like protein N646_1055 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) N646_1056 ENOG4105DZ2 Transcriptional regulator N646_1060 ENOG4105CCT upf0313 protein N646_1064 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) N646_1066 ENOG4105CK6 Two component transcriptional regulator (Winged helix family N646_1067 ENOG41062D9 Histidine kinase N646_1070 ENOG4105JQN Transcriptional regulator N646_1071 ENOG4105J12 Multidrug resistance protein mdtN N646_1073 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) N646_1077 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) N646_1078 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) N646_1079 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) N646_1081 ENOG4105DJY efflux transporter, rnd family, mfp subunit N646_1085 ENOG4105N6Y Thioredoxin N646_1086 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) N646_1088 ENOG4108ZXC Two component transcriptional regulator, luxr family N646_1089 ENOG4106AFQ Histidine kinase N646_1090 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein N646_1091 ENOG4106WHD Tetrathionate reductase N646_1092 ENOG4105DB1 molybdopterin oxidoreductase N646_1094 ENOG4105NQN cytochrome C N646_1095 ENOG4105F1S paraquat-inducible protein a N646_1096 ENOG4105DY2 Paraquat-inducible protein b N646_1100 ENOG4108J59 Extracellular solute-binding protein, family 5 N646_1101 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) N646_1102 ENOG4105CFV Tetratricopeptide repeat protein N646_1103 ENOG4105Q4A inner membrane protein yciS N646_1104 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) N646_1105 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) N646_1106 ENOG4105CAT Cytidine monophosphate kinase N646_1108 ENOG4105ERU peptidase N646_1109 ENOG4105UBK short-chain dehydrogenase reductase N646_1112 ENOG4105C0B DNA polymerase III (alpha subunit) N646_1113 ENOG4107R88 Chemotaxis protein (CheV) N646_1115 ENOG4105DAG ROK family N646_1116 ENOG4105CA9 Pyruvate kinase N646_1117 ENOG4108NRW Phospholipase, patatin family N646_1120 ENOG4105C8J )-transporter N646_1122 ENOG4105CI1 PTS System N646_1123 ENOG4105F8V Hydrolase, tatD family N646_1124 ENOG4107QRG dna polymerase iii N646_1125 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) N646_1126 ENOG4105HHA aminodeoxychorismate lyase N646_1128 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) N646_1129 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) N646_1130 ENOG4105CHR reductase N646_1131 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase N646_1132 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) N646_1133 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) N646_1134 ENOG4105VGS 50s ribosomal protein l32 N646_1135 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein N646_1136 ENOG4108UHJ MAF-like protein N646_1137 ENOG4105EI2 Pseudouridine synthase N646_1138 ENOG4105C03 ribonuclease N646_1139 ENOG4105CHH sulfate transporter N646_1141 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase N646_1143 ENOG4105DBI uridine monophosphokinase N646_1144 ENOG4105D1F ATP-binding protein N646_1145 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) N646_1147 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) N646_1149 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) N646_1150 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving N646_1151 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) N646_1152 ENOG4105BZU Histidine kinase N646_1153 ENOG4107R28 alpha amylase, catalytic region N646_1154 ENOG4108JJB ABC transporter N646_1155 ENOG4105C7J ABC transporter, permease N646_1157 ENOG4105PQ6 UPF0208 membrane protein N646_1158 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) N646_1159 ENOG4108DNC Involved in acetate metabolism (By similarity) N646_1161 ENOG4105CHF Glutathione S-transferase N646_1162 ENOG4108JQ7 (ABC) transporter N646_1163 ENOG4105C3U ABC transporter N646_1164 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component N646_1165 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component N646_1166 ENOG4107QSI ABC, transporter N646_1167 ENOG4108ZAF Molybdopterin N646_1168 ENOG4105M00 molybdopterin converting factor, subunit 1 N646_1169 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) N646_1170 ENOG4108RIR Molybdenum cofactor biosynthesis protein N646_1171 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) N646_1172 ENOG4105CHW UPF0052 protein N646_1174 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family N646_1175 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) N646_1176 ENOG4105C6N Formate acetyltransferase N646_1177 ENOG4105DGN Electron transport complex N646_1178 ENOG4108R3D Electron transport complex N646_1180 ENOG4105D6A Electron transport complex N646_1181 ENOG4108UQQ Electron transport complex N646_1182 ENOG4105DZB Electron transport complex N646_1183 ENOG4105CSM endonuclease III N646_1184 ENOG4108UYE Lactoylglutathione lyase N646_1185 ENOG4106WH9 Protein of unknown function (DUF2753) N646_1186 ENOG4105EIY sodium-type flagellar protein motY N646_1188 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) N646_1189 ENOG4105D3Y Na H antiporter N646_1216 ENOG4105ED4 portal protein N646_1233 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) N646_1236 ENOG4105M2J Glutaredoxin N646_1237 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) N646_1240 ENOG4108EKI Dehydrogenase N646_1241 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein N646_1242 ENOG4105EYW Ion transport protein N646_1243 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) N646_1244 ENOG4105DFD Na H antiporter N646_1247 ENOG4106V8H Nucleoid-associated protein N646_1248 ENOG4105YDX UPF0352 protein N646_1249 ENOG4105E68 Sulfatase N646_1250 ENOG4105DGU Histone deacetylase N646_1252 ENOG4108RU0 short-chain dehydrogenase reductase N646_1255 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) N646_1256 ENOG41069NU Nitroreductase N646_1258 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase N646_1259 ENOG4105D07 Signal peptide peptidase, SppA N646_1260 ENOG4105HDK L-asparaginase N646_1261 ENOG4105VUT cytoplasmic protein N646_1263 ENOG4105E0X reductase N646_1264 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase N646_1265 ENOG4105DSB aldose 1-epimerase N646_1266 ENOG4107SDU Methyl-accepting chemotaxis N646_1267 ENOG4105DHI Methyltransferase N646_1271 ENOG4105G6Z alkaline phosphatase N646_1274 ENOG41067V3 Antibiotic biosynthesis monooxygenase N646_1276 ENOG4108ZZ3 UPF0260 protein N646_1277 ENOG4105Y3U Transglycosylase-associated protein N646_1278 ENOG4105KRS Proteinase inhibitor N646_1279 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) N646_1280 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) N646_1281 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) N646_1282 ENOG4107QMP dna polymerase iii subunits gamma and tau N646_1283 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) N646_1286 ENOG4105I93 response regulator N646_1287 ENOG4105EJC lysr family transcriptional regulator N646_1288 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase N646_1289 ENOG4105E96 Colicin v production protein N646_1290 ENOG4108S3P Sporulation domain protein N646_1291 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase N646_1292 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) N646_1293 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) N646_1295 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) N646_1296 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) N646_1297 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) N646_1298 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) N646_1299 ENOG4105Q8W reductase N646_1301 ENOG4105MH2 YfcL protein N646_1302 ENOG4108BPE -transporting atpase N646_1303 ENOG4105EN6 Membrane N646_1304 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase N646_1305 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) N646_1306 ENOG4108DG9 Smr protein MutS2 N646_1307 ENOG4108BY2 phosphohistidine phosphatase N646_1308 ENOG4107QXK peptidase N646_1310 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase N646_1311 ENOG4105CHU acetyl-coa acetyltransferase N646_1315 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation N646_1316 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation N646_1317 ENOG410903C (LipO)protein N646_1318 ENOG4105KWW Biogenesis protein N646_1319 ENOG4108M1T Cytochrome c-type biogenesis protein N646_1320 ENOG4107QX9 Thiol disulfide interChange protein N646_1321 ENOG4105DA4 cytochrome c-type biogenesis protein N646_1322 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) N646_1323 ENOG4105X3C heme exporter protein N646_1324 ENOG41060IM Heme exporter protein N646_1325 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) N646_1326 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) N646_1329 ENOG4108V3W Chemotaxis protein, CheW N646_1331 ENOG4107QJE Chromosome Partitioning Protein N646_1332 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) N646_1333 ENOG4105CBS Chea signal transduction histidine kinase N646_1334 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) N646_1335 ENOG4108VYJ response regulator receiver protein N646_1336 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) N646_1337 ENOG4107R21 site-determining protein N646_1338 ENOG4105FZW flagellar biosynthesis regulator FlhF N646_1339 ENOG4105D7B Flagellar biosynthesis protein flha N646_1340 ENOG4105D00 flagellar biosynthetic protein flhB N646_1341 ENOG4105D19 Role in flagellar biosynthesis (By similarity) N646_1342 ENOG4105VS8 Flagellar biosynthetic protein fliq N646_1343 ENOG4105CN7 Flagellar biosynthetic protein FliP N646_1344 ENOG4105VTB flagellar biosynthesis protein fliO N646_1345 ENOG4105DD5 Flagellar motor switch protein N646_1346 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) N646_1353 ENOG4108JIR Flagellum-specific ATP synthase N646_1355 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) N646_1356 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) N646_1357 ENOG4105VQ0 flagellar hook-basal body complex protein fliE N646_1358 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family N646_1359 ENOG4105BZU Histidine kinase N646_1360 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family N646_1361 ENOG4105MQ3 flagellar protein FliS N646_1363 ENOG4107BRV flagellar capping protein N646_1364 ENOG41063QE flagellar protein FlaG N646_1365 ENOG4105I03 Flagellin N646_1366 ENOG4105I03 Flagellin N646_1367 ENOG4105I03 Flagellin N646_1368 ENOG4105EZR dyp-type peroxidase family protein N646_1369 ENOG4105QZU Inner membrane protein YfeZ N646_1373 ENOG4105KUZ arsenate reductase N646_1374 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) N646_1377 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) N646_1380 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen N646_1383 ENOG4105ERG peptidase m48, ste24p N646_1384 ENOG4105K89 arsenate reductase N646_1385 ENOG4105CS1 NAD(P)H quinone oxidoreductase N646_1388 ENOG4105C2W permease N646_1390 ENOG4105CXB phosphoribosylaminoimidazole synthetase N646_1391 ENOG4108V3E phosphoribosylglycinamide formyltransferase N646_1393 ENOG4105E7A Glutamine amidotransferase N646_1394 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) N646_1395 ENOG4107QPN acyl-Coa dehydrogenase N646_1401 ENOG4108JDX DNA polymerase iii, epsilon subunit N646_1402 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) N646_1403 ENOG4105D1A Methyltransferase N646_1404 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) N646_1405 ENOG4105E9H Lytic Murein transglycosylase N646_1407 ENOG4107NA1 Endonuclease Exonuclease phosphatase N646_1408 ENOG4108YZA Nitrogen regulatory protein pii N646_1409 ENOG4105N7H Cytochrome N646_1410 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) N646_1411 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) N646_1412 ENOG4105C0B DNA polymerase III (alpha subunit) N646_1413 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) N646_1414 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) N646_1415 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) N646_1416 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) N646_1418 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) N646_1419 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) N646_1421 ENOG4105DZP Membrane-associated zinc metalloprotease N646_1422 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) N646_1423 ENOG4105KNE Phosphatidate cytidylyltransferase N646_1424 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) N646_1425 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) N646_1426 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) N646_1427 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) N646_1428 ENOG4105CE9 30S ribosomal protein S2 N646_1429 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) N646_1430 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) N646_1431 ENOG4108T8E UPF0325 protein N646_1432 ENOG4105DR9 pseudouridine synthase N646_1433 ENOG4105DR9 pseudouridine synthase N646_1438 ENOG4108UPT UPF0178 protein N646_1439 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) N646_1440 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase N646_1445 ENOG4105CFC Transporter N646_1446 ENOG4105NRA 50s ribosomal protein l31 type b N646_1447 ENOG4108R96 Methyltransferase, YaeB family N646_1448 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) N646_1450 ENOG4105W1I UPF0253 protein N646_1452 ENOG4105C8J )-transporter N646_1456 ENOG4105C9U ATP-dependent DNA helicase RecQ N646_1457 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) N646_1459 ENOG4105BZU Histidine kinase N646_1461 ENOG4105CJ2 (LipO)protein N646_1462 ENOG4105CJ2 (LipO)protein N646_1463 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) N646_1464 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) N646_1465 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) N646_1466 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) N646_1467 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) N646_1468 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) N646_1469 ENOG4105M85 Bola protein N646_1470 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) N646_1471 ENOG4105IEY (LipO)protein N646_1472 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) N646_1475 ENOG4105K6V RNA polymerase N646_1478 ENOG4105DRB nucleoside-specific channel-forming protein N646_1479 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) N646_1480 ENOG4107S0N DJ-1 family N646_1481 ENOG4105C9B Cysteine desulfurase N646_1482 ENOG4105BZU Histidine kinase N646_1483 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) N646_1484 ENOG4105CUZ uba thif-type nad fad binding protein N646_1485 ENOG4105CA3 membrane-bound lytic murein transglycosylase N646_1487 ENOG4107QZM n-acetylglutamate synthase N646_1490 ENOG4107QYX exodeoxyribonuclease v alpha N646_1491 ENOG4107QKA exodeoxyribonuclease V beta N646_1492 ENOG4105DSY exodeoxyribonuclease V, gamma N646_1493 ENOG4105E68 Sulfatase N646_1495 ENOG4105EVZ LysR family transcriptional regulator N646_1496 ENOG4105X2V dna damage-inducible protein N646_1499 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) N646_1500 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase N646_1501 ENOG4105CXY transporter N646_1502 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) N646_1503 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) N646_1504 ENOG4105E98 transcriptional regulator DeoR family N646_1505 ENOG4105C6V Glycerol-3-phosphate dehydrogenase N646_1506 ENOG4107RX3 Mg2 transporter protein cora family protein N646_1507 ENOG4108RS6 transposase N646_1511 ENOG4105CQ4 Transcriptional regulator N646_1512 ENOG41064T2 transcriptional regulator, lysR family N646_1514 ENOG41086KC Transcriptional regulator N646_1520 ENOG4108IQE Amp-dependent synthetase and ligase N646_1521 ENOG4105ETT transcriptional Regulator, LysR family N646_1522 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) N646_1523 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) N646_1525 ENOG4105EAC phosphoserine phosphatase N646_1527 ENOG4105D3A purine nucleoside phosphorylase DeoD-type N646_1528 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) N646_1529 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) N646_1530 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) N646_1532 ENOG4105D9N nucleoside N646_1533 ENOG4105EYA deoxyribonuclease N646_1535 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) N646_1539 ENOG4108YYD acetyltransferase N646_1540 ENOG4105XPQ lipid carrier protein N646_1542 ENOG4105BZU Histidine kinase N646_1543 ENOG4105CFP Peptidase U32 N646_1544 ENOG4106RZ4 Peptidase U32 N646_1545 ENOG4105C3S Mate efflux family protein N646_1548 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) N646_1549 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) N646_1550 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) N646_1551 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) N646_1552 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) N646_1553 ENOG4105CHV Transcription elongation factor NusA N646_1554 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) N646_1556 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) N646_1557 ENOG4105EEI dihydropteroate synthase N646_1558 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) N646_1559 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) N646_1560 ENOG4105HBR Rna-binding protein N646_1561 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) N646_1562 ENOG4107QE9 Inherit from COG: Membrane N646_1563 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase N646_1566 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) N646_1567 ENOG4105DR5 peptidase N646_1570 ENOG4108YX9 iron--sulfur cluster insertion protein erpA N646_1571 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase N646_1573 ENOG4105F4G Membrane N646_1574 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) N646_1575 ENOG4105BZU Histidine kinase N646_1576 ENOG4107QRA Extracellular solute-binding protein, family 5 N646_1578 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component N646_1579 ENOG4105C3U ABC transporter N646_1580 ENOG4108JQ7 (ABC) transporter N646_1582 ENOG4105RD7 BadF BadG BcrA BcrD N646_1583 ENOG4105E2D ec 3.2.1.52 N646_1586 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) N646_1590 ENOG4108YZA Nitrogen regulatory protein pii N646_1591 ENOG4105XTV UPF0231 protein N646_1592 ENOG4107QIJ Aconitate hydratase 2 N646_1593 ENOG4105D78 K07001 NTE family protein N646_1594 ENOG4105BZ4 penicillin-binding protein N646_1595 ENOG4105CQ7 ATP-dependent helicase N646_1596 ENOG4105PW4 Sugar fermentation stimulation protein homolog N646_1597 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters N646_1598 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) N646_1599 ENOG4105DJ0 Poly(A) Polymerase N646_1600 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase N646_1601 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) N646_1602 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) N646_1603 ENOG4105D1S lipid A biosynthesis N646_1604 ENOG4105E3A (ABC) transporter N646_1605 ENOG4105DA5 (ABC) transporter N646_1606 ENOG4105CHH sulfate transporter N646_1607 ENOG41077A9 carbonic anhydrase N646_1608 ENOG4108UGV hypoxanthine phosphoribosyltransferase N646_1609 ENOG410630P Transcriptional regulator N646_1610 ENOG4107QN2 dihydrolipoyl dehydrogenase N646_1611 ENOG4107QSN dihydrolipoamide acetyltransferase N646_1612 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) N646_1613 ENOG41073TP transcriptional regulator N646_1615 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase N646_1617 ENOG4107QHF type ii secretion system protein e N646_1618 ENOG4105D7Q type ii secretion system N646_1619 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) N646_1620 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) N646_1621 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) N646_1622 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) N646_1623 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) N646_1624 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) N646_1625 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) N646_1626 ENOG4105K5M 30s ribosomal protein S16 N646_1627 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY N646_1628 ENOG4106KVJ cytochrome C assembly protein N646_1629 ENOG4108JU6 CBS domain protein N646_1632 ENOG4105D9M gamma-glutamylcysteine synthetase N646_1634 ENOG4105W39 Membrane N646_1636 ENOG4105D9Q decarboxylase (Beta subunit) N646_1637 ENOG4107QSA Oxaloacetate decarboxylase N646_1640 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) N646_1641 ENOG4105CFH Aspartokinase N646_1642 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) N646_1643 ENOG4105Y3E Modulates RecA activity (By similarity) N646_1644 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) N646_1645 ENOG4107TH8 cina domain protein N646_1646 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) N646_1647 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) N646_1649 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) N646_1650 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) N646_1651 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) N646_1652 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) N646_1653 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) N646_1654 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) N646_1655 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) N646_1656 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) N646_1657 ENOG4105DXN mazG family N646_1658 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) N646_1659 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) N646_1660 ENOG4105BZU Histidine kinase N646_1661 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) N646_1662 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) N646_1663 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) N646_1664 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) N646_1665 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) N646_1666 ENOG4105C3F Signal peptidase i N646_1667 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) N646_1671 ENOG4105EMN RNA polymerase sigma factor N646_1672 ENOG4108IYU L-aspartate oxidase N646_1674 ENOG4105Y75 tpr repeat protein N646_1675 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) N646_1677 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family N646_1678 ENOG4105D0A hydroxylase N646_1680 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) N646_1681 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase N646_1682 ENOG4105E66 phosphoriboisomerase A N646_1683 ENOG4108JQ1 Dehydrogenase N646_1684 ENOG4105MPN Membrane N646_1685 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) N646_1688 ENOG4105D64 Mechanosensitive ion channel N646_1689 ENOG4105D2N Aldolase N646_1690 ENOG4105BZA Phosphoglycerate kinase N646_1691 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase N646_1692 ENOG4105D05 Receptor N646_1693 ENOG4108R4R Iron-regulated virulence regulatory protein N646_1694 ENOG4105CV1 Transketolase (EC 2.2.1.1) N646_1695 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP N646_1697 ENOG4105GPY SprT protein N646_1699 ENOG4105RWS endonuclease I N646_1700 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) N646_1701 ENOG4105D7Z glutathione synthase N646_1702 ENOG4108UJU UPF0301 protein N646_1703 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) N646_1704 ENOG4105CZX twitching motility protein N646_1705 ENOG4105CZX twitching motility protein N646_1706 ENOG4105DFA alanine racemase domain protein N646_1707 ENOG4105II7 pyrroline-5-carboxylate reductase N646_1708 ENOG4108VIA integral membrane protein N646_1709 ENOG4105VZ9 UPF0235 protein N646_1711 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) N646_1712 ENOG4105CSA Coproporphyrinogen iii oxidase N646_1713 ENOG4105CSV Glutaminase N646_1715 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) N646_1716 ENOG4105CEN a g-specific adenine glycosylase N646_1717 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) N646_1719 ENOG4105C8Q Methyl-accepting chemotaxis N646_1724 ENOG4108ESY Metal dependent phosphohydrolase N646_1725 ENOG4105ETE Transcriptional regulator (LacI family N646_1726 ENOG410901P UPF0249 protein N646_1727 ENOG4105F8D glycoside hydrolase family 4 N646_1728 ENOG4105VCP PTS System N646_1729 ENOG4105CK1 PTS System N646_1732 ENOG41061TZ Short-chain dehydrogenase reductase Sdr N646_1733 ENOG4105EXU Membrane N646_1735 ENOG4108K5H permease YjgP YjgQ family protein N646_1736 ENOG4108M8S permease YjgP YjgQ family protein N646_1737 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) N646_1738 ENOG4105MYG DNA polymerase iii, chi subunit N646_1739 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) N646_1741 ENOG4108MJ3 acetyltransferase N646_1744 ENOG4105CEU Arginine dihydrolase N646_1745 ENOG4105DBV ornithine carbamoyltransferase N646_1746 ENOG4105CXT aspartate transcarbamylase N646_1747 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) N646_1748 ENOG4105KME endoribonuclease L-psp N646_1749 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase N646_1750 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) N646_1751 ENOG4105VFK BolA family N646_1753 ENOG4105E3I toluene tolerance N646_1754 ENOG4107PE3 Mammalian cell entry related domain protein N646_1755 ENOG4105CY3 ABC transporter, permease N646_1756 ENOG4105DHJ ABC, transporter N646_1758 ENOG4105C2X Arabinose 5-phosphate isomerase N646_1760 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA N646_1761 ENOG4108IUZ ABC transporter N646_1762 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) N646_1763 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA N646_1764 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN N646_1765 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) N646_1766 ENOG41080Z8 PHOSPHOCARRIER protein N646_1767 ENOG4105CJW magnesium transporter N646_1768 ENOG4105CMS peptidase U62, modulator of DNA gyrase N646_1769 ENOG4105N42 UPF0307 protein N646_1770 ENOG4105C5I Dehydrogenase N646_1771 ENOG4105D3G Pseudouridine synthase N646_1772 ENOG4105K3M )-transporter N646_1773 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) N646_1774 ENOG4108IAB Phoh family N646_1775 ENOG4105D1U peptidase U62 modulator of DNA gyrase N646_1777 ENOG4105QD6 exported protein N646_1778 ENOG4105C03 ribonuclease N646_1779 ENOG4108Z03 MAF-like protein N646_1780 ENOG4105VQ7 Rod shape-determining protein MreD N646_1781 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) N646_1782 ENOG4105DFF Rod shape-determining protein mreb N646_1791 ENOG4105D7Q type ii secretion system N646_1792 ENOG4107QHF type ii secretion system protein e N646_1799 ENOG41062P1 Diguanylate cyclase phosphodiesterase N646_1800 ENOG4108UUM single-stranded DNA-binding protein N646_1801 ENOG41086KC Transcriptional regulator N646_1802 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase N646_1803 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) N646_1805 ENOG4105C5R Aminotransferase N646_1807 ENOG4105CFH Aspartokinase N646_1808 ENOG4105C3R Methionine synthase N646_1809 ENOG4105EEQ Na H antiporter N646_1816 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) N646_1817 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) N646_1818 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) N646_1822 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) N646_1824 ENOG4105MYN Zinc uptake regulation protein N646_1826 ENOG4107QP8 phosphohexose isomerase N646_1827 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme N646_1828 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) N646_1829 ENOG4105CDU Replicative dna helicase N646_1831 ENOG4105K9Q Binds to the 23S rRNA (By similarity) N646_1832 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) N646_1834 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) N646_1835 ENOG4105DJV ribulose-phosphate 3-epimerase N646_1836 ENOG4105DFE Dna adenine methylase N646_1838 ENOG4105D49 3-dehydroquinate synthase N646_1839 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) N646_1840 ENOG4105E4G Type IV pilus N646_1845 ENOG4108JQC penicillin-binding protein 1A N646_1846 ENOG4105C5Q Transcriptional regulator N646_1847 ENOG4105EHV domain protein N646_1848 ENOG4107QN2 dihydrolipoyl dehydrogenase N646_1851 ENOG4105CH7 arginosuccinase N646_1852 ENOG4105CDH Citrulline--aspartate ligase N646_1853 ENOG4105CAS nag kinase N646_1854 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase N646_1855 ENOG4105CWC Acetylornithine deacetylase N646_1856 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) N646_1858 ENOG4105SYT Methylenetetrahydrofolate reductase N646_1859 ENOG4105CFH Aspartokinase N646_1860 ENOG4105C28 cystathionine N646_1861 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) N646_1862 ENOG4105C6K Malic enzyme N646_1863 ENOG4108UQY Iron-storage protein N646_1864 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) N646_1865 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) N646_1866 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) N646_1867 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) N646_1869 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) N646_1870 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) N646_1871 ENOG4105WWK YheO domain protein N646_1872 ENOG4108V1T peptidylprolyl cis-trans isomerase N646_1874 ENOG41069P5 Protein slyX homolog N646_1875 ENOG4105D44 asparaginase N646_1876 ENOG4108YZY peptidylprolyl cis-trans isomerase N646_1879 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein N646_1880 ENOG4105C5H ABC transporter N646_1882 ENOG4105DNZ Alpha Beta Hydrolase N646_1883 ENOG4105YP7 UPF0270 protein N646_1884 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) N646_1885 ENOG4107RYR Transcriptional regulator, Crp Fnr family N646_1887 ENOG4105C26 Dehydrogenase N646_1889 ENOG4105C8Y Acetylornithine aminotransferase N646_1890 ENOG4105DDQ anthranilate synthase N646_1894 ENOG4105C31 Tryptophanyl-tRNA synthetase N646_1895 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) N646_1896 ENOG4105C2N RNA methyltransferase TrmH family group 3 N646_1897 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) N646_1898 ENOG4105KPV Transcriptional regulator N646_1899 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) N646_1900 ENOG4108UV7 flagellar protein motX N646_1901 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis N646_1903 ENOG4105EPW hflc protein N646_1904 ENOG4107QJR hflk protein N646_1905 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) N646_1906 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) N646_1907 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) N646_1908 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) N646_1910 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase N646_1911 ENOG4105K8N protein family UPF0079, ATPase N646_1913 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) N646_1914 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) N646_1915 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) N646_1916 ENOG4105DJ4 phosphatidylserine decarboxylase N646_1919 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) N646_1920 ENOG4107YZP Rhodanese domain protein N646_1921 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) N646_1922 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase N646_1923 ENOG4105D7W serine acetyltransferase N646_1924 ENOG41063SB peptidase N646_1926 ENOG41062JF Transcriptional regulator N646_1928 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) N646_1930 ENOG4105E33 succinate dehydrogenase N646_1931 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) N646_1932 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) N646_1934 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) N646_1935 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein N646_1936 ENOG4105KT7 mgtC SapB transporter N646_1939 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) N646_1940 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) N646_1941 ENOG4107QI1 Mate efflux family protein N646_1942 ENOG4108RS6 transposase N646_1943 ENOG4105CTQ phosphohexokinase N646_1944 ENOG41076HS cation diffusion facilitator family transporter N646_1945 ENOG4108SPG Periplasmic Protein N646_1946 ENOG4105E3W Two component transcriptional regulator (Winged helix family N646_1947 ENOG4105E0F Histidine kinase N646_1949 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) N646_1950 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 N646_1951 ENOG4108IJ0 Aspartate ammonia-lyase N646_1952 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter N646_1953 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) N646_1955 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) N646_1957 ENOG4107QN1 sodium solute N646_1960 ENOG4105C9Q fumarate hydratase class II N646_1961 ENOG4105BZU Histidine kinase N646_1962 ENOG4105D8G Major Facilitator superfamily N646_1965 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) N646_1966 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) N646_1967 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein N646_1968 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase N646_1969 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) N646_1970 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) N646_1971 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) N646_1973 ENOG4105C5H ABC transporter N646_1979 ENOG4105CXN decarboxylase N646_1980 ENOG4105D5Q Arginine ornithine antiporter N646_1981 ENOG4108M3R transcriptional activator CadC N646_1982 ENOG4105W1Y Transcriptional regulator N646_1984 ENOG4105DC1 bifunctional purine biosynthesis protein purh N646_1985 ENOG4105C12 Phosphoribosylglycinamide synthetase N646_1989 ENOG4105R2J Conserved Protein N646_1990 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase N646_1991 ENOG4108RG0 uracil-dna glycosylase N646_1992 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) N646_1993 ENOG4105E09 nadh pyrophosphatase N646_1994 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor N646_1995 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) N646_1996 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) N646_1997 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) N646_1998 ENOG4108VZM 50s ribosomal protein L10 N646_1999 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) N646_2000 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) N646_2001 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) N646_2002 ENOG4105PM1 preprotein translocase subunit SecE N646_2003 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) N646_2004 ENOG4105CS9 pantothenic acid kinase N646_2005 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase N646_2006 ENOG4105D4A Cell wall formation (By similarity) N646_2008 ENOG4105JIM Phosphatidylserine synthase N646_2013 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) N646_2015 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) N646_2016 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) N646_2028 ENOG4108YGG dna repair protein N646_2039 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) N646_2040 ENOG4107R73 Mate efflux family protein N646_2042 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) N646_2043 ENOG4105E55 glycerol-3-phosphate acyltransferase N646_2044 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) N646_2045 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) N646_2046 ENOG4105X6C Flagellar basal body-associated protein FliL N646_2047 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) N646_2048 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) N646_2049 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) N646_2050 ENOG4105CRP Part of the ABC transporter FtsEX involved in N646_2051 ENOG4105CAK Cell division ATP-binding protein ftsE N646_2052 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) N646_2053 ENOG4106H78 methyltransferase N646_2055 ENOG41076UM multiple antibiotic resistance (MarC)-related protein N646_2065 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase N646_2066 ENOG41082YX Transcriptional regulator, arsr family N646_2067 ENOG4105D58 Diguanylate phosphodiesterase N646_2068 ENOG410829K Lysine exporter protein (Lyse ygga) N646_2069 ENOG4108EUD Lysophospholipase N646_2070 ENOG4105DQF Hydrolase N646_2073 ENOG4106IUH DTW domain containing protein N646_2075 ENOG4105BZU Histidine kinase N646_2076 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant N646_2077 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) N646_2079 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) N646_2080 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) N646_2082 ENOG4105XQ6 frataxin-like protein N646_2083 ENOG4107T0K Adenylate cyclase N646_2084 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) N646_2085 ENOG41076E6 Uroporphyrinogen-III Synthase N646_2086 ENOG4105ECF c-methyltransferase N646_2087 ENOG410601J HemY protein N646_2091 ENOG4107QK7 reductase N646_2092 ENOG4108ZIT Ferredoxin, 2FE-2S N646_2093 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) N646_2095 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) N646_2096 ENOG4105K63 Thioredoxin N646_2097 ENOG4105C1J atp-dependent rna helicase N646_2098 ENOG4105C9X ppx gppa phosphatase N646_2100 ENOG4105EX9 Membrane N646_2102 ENOG4105C9U ATP-dependent DNA helicase RecQ N646_2103 ENOG4105FR1 rard protein N646_2106 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) N646_2108 ENOG4105C4R Atp-dependent dna helicase N646_2110 ENOG4105E18 UPF0276 protein N646_2116 ENOG4105DC7 peptidase M24 N646_2116 ENOG4105DC7 peptidase M24 N646_2117 ENOG4105D41 biosynthesis protein thiH N646_2118 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) N646_2119 ENOG4105WHD thiamine biosynthesis protein ThiS N646_2120 ENOG4105D06 uba thif-type nad fad binding protein N646_2122 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) N646_2123 ENOG4105WMR Protein CrcB homolog N646_2124 ENOG4105E3B Multicopper oxidase N646_2129 ENOG4108Z0R Transferase N646_2130 ENOG4105SG3 Protein of unknown function (DUF1488) N646_2131 ENOG4105E2X shikimate dehydrogenase N646_2132 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) N646_2133 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) N646_2134 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) N646_2135 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit N646_2136 ENOG4108WI1 Dna topoisomerase N646_2137 ENOG4108RPN Protein smg homolog N646_2138 ENOG4105C79 DNA protecting protein DprA N646_2140 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) N646_2141 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) N646_2142 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B N646_2143 ENOG4105C1A potassium transporter peripheral membrane N646_2144 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) N646_2146 ENOG4108UT2 hemolysin iii N646_2147 ENOG4108N23 SpoOM-related protein N646_2150 ENOG4105PC1 Conserved Protein N646_2152 ENOG4105E27 serine threonine protein kinase N646_2153 ENOG4108Z33 Thiol disulfide Interchange Protein N646_2155 ENOG4106HNH Acyl-transferase N646_2157 ENOG4105C0P Mg chelatase subunit ChlI N646_2159 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit N646_2160 ENOG4105CM2 brancheD-chain amino acid aminotransferase N646_2161 ENOG4105C01 Dihydroxy-acid dehydratase N646_2162 ENOG4105C7B Threonine dehydratase N646_2163 ENOG4105F52 Transcriptional regulator N646_2164 ENOG4105CZQ inner membrane transport protein YdhC N646_2166 ENOG4105EAD ABC transporter N646_2167 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) N646_2168 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) N646_2169 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) N646_2170 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) N646_2171 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) N646_2172 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) N646_2174 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) N646_2175 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) N646_2176 ENOG410684E atp synthase N646_2177 ENOG4105FA0 parb-like partition protein N646_2178 ENOG4107QJE Chromosome Partitioning Protein N646_2179 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) N646_2180 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) N646_2181 ENOG4105QTB Flavodoxin N646_2182 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) N646_2183 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins N646_2184 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) N646_2186 ENOG4105CDA abc transporter atp-binding protein N646_2187 ENOG4105E5Q amino acid AbC transporter N646_2188 ENOG4105EAB amino acid AbC transporter N646_2189 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) N646_2190 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) N646_2191 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) N646_2192 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) N646_2193 ENOG4108RS6 transposase N646_2196 ENOG4108ZNX Heat shock protein N646_2197 ENOG4105JKW Valine--pyruvate aminotransferase N646_2198 ENOG4107T9C Alpha amylase catalytic region N646_2199 ENOG4105C38 Glycyl-tRNA synthetase beta subunit N646_2200 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit N646_2204 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) N646_2207 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family N646_2209 ENOG4105CHU acetyl-coa acetyltransferase N646_2210 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase N646_2211 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein N646_2212 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) N646_2213 ENOG4108RR8 protoporphyrinogen oxidase N646_2218 ENOG4105EMY transcriptional regulator N646_2219 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase N646_2220 ENOG4105W0Z cytoplasmic protein N646_2221 ENOG4105BZS acriflavin resistance protein N646_2222 ENOG410624X efflux transporter, rnd family, mfp subunit N646_2223 ENOG41067SE Tetr family transcriptional regulator N646_2224 ENOG4105C4R Atp-dependent dna helicase N646_2225 ENOG4105MPD Cytochrome N646_2227 ENOG4108JQ6 ABC transporter N646_2228 ENOG4107QSI ABC, transporter N646_2229 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component N646_2230 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component N646_2239 ENOG4105DIQ Transcriptional regulator N646_2240 ENOG41064T2 transcriptional regulator, lysR family N646_2241 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) N646_2242 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) N646_2243 ENOG4105C01 Dihydroxy-acid dehydratase N646_2244 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family N646_2245 ENOG4105C6Z Gluconate N646_2246 ENOG4108UHU Aldolase N646_2247 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) N646_2248 ENOG4107RSM transcriptional regulator N646_2256 ENOG4105DC8 reductase N646_2257 ENOG4105D6S protein involved in catabolism of external DNA N646_2258 ENOG4105DGW oligopeptidase A N646_2259 ENOG4108VVK transcriptional Regulator, AsnC N646_2260 ENOG4105BZU Histidine kinase N646_2261 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) N646_2263 ENOG4105EMK carboxylate amino acid amine transporter N646_2264 ENOG4108M6U Universal stress protein A N646_2265 ENOG41090A1 ferritin N646_2266 ENOG4108V6B universal stress protein B N646_2267 ENOG4105CBX hi0933 family N646_2268 ENOG4108JUA Transcriptional regulator N646_2273 ENOG4107TE5 Lipid kinase N646_2280 ENOG4105DSF transport protein N646_2281 ENOG4105BZU Histidine kinase N646_2283 ENOG4105CGY Dna recombination protein N646_2284 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) N646_2285 ENOG4105JC1 sterol-binding domain protein N646_2286 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) N646_2287 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) N646_2288 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) N646_2289 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) N646_2293 ENOG4105F8V Hydrolase, tatD family N646_2294 ENOG4105D52 delta-aminolevulinic acid dehydratase N646_2295 ENOG4105KD7 acetyltransferase N646_2296 ENOG4105C2M dna polymerase I N646_2297 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) N646_2298 ENOG4106RE7 Cytochrome N646_2300 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) N646_2301 ENOG4105XCT Protein of unknown function (DUF2489) N646_2302 ENOG4105D4P Coproporphyrinogen iii oxidase N646_2303 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) N646_2304 ENOG4105BZU Histidine kinase N646_2305 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family N646_2306 ENOG4105CUX Signal transduction histidine kinase N646_2308 ENOG4105C5F glutamine synthetase N646_2312 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) N646_2314 ENOG4107S2Z UPF0761 membrane protein N646_2315 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) N646_2316 ENOG4105SUU thioesterase domain N646_2318 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase N646_2319 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) N646_2320 ENOG4105VEJ Heat shock protein N646_2321 ENOG4108XKW General secretion pathway protein C N646_2323 ENOG4107QHF type ii secretion system protein e N646_2324 ENOG4105D7Q type ii secretion system N646_2325 ENOG4108VAU general secretion pathway protein G N646_2326 ENOG4105VWV general secretion pathway protein h N646_2327 ENOG4105X5Z General secretion pathway protein I N646_2328 ENOG4108WWZ General secretion pathway protein J N646_2329 ENOG4108RTD type II secretion system protein K N646_2330 ENOG4108BY5 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) N646_2331 ENOG4105U1E general secretion pathway protein M N646_2332 ENOG4105PIC general secretion pathway protein N N646_2334 ENOG4107RK2 ADP-ribose diphosphatase NudE N646_2335 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) N646_2337 ENOG4105MJ2 Competence protein N646_2338 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) N646_2340 ENOG4105BZM domain protein N646_2342 ENOG4108RRZ Transcription elongation factor GreB N646_2344 ENOG4105DPZ Two component transcriptional regulator (Winged helix family N646_2345 ENOG4105E0F Histidine kinase N646_2346 ENOG4105C2W permease N646_2347 ENOG4105CB5 ATP-dependent DNA helicase recG N646_2348 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase N646_2349 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) N646_2351 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) N646_2352 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) N646_2355 ENOG4109015 Biopolymer transport protein exbD tolR N646_2360 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component N646_2361 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component N646_2362 ENOG4107QRA Extracellular solute-binding protein, family 5 N646_2364 ENOG4108JQ7 (ABC) transporter N646_2366 ENOG4105DSJ YicC domain protein N646_2367 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) N646_2368 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) N646_2369 ENOG4105D1S lipid A biosynthesis N646_2370 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) N646_2371 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase N646_2372 ENOG4105C8Q Methyl-accepting chemotaxis N646_2373 ENOG4105W5Q DNA repair protein (RadC N646_2374 ENOG4105KDC 50s ribosomal protein l28 N646_2377 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) N646_2378 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) N646_2379 ENOG4108JMC lipopolysaccharide core biosynthesis protein N646_2381 ENOG4106WTF Glycosyl transferase, family 2 N646_2382 ENOG4105DKP glycosyl transferase, family 9 N646_2383 ENOG41080IJ Diacylglycerol kinase N646_2384 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) N646_2385 ENOG4105C1B dTDP-glucose 4-6-dehydratase N646_2386 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) N646_2394 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) N646_2395 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase N646_2396 ENOG4105XA0 heptosyltransferase ii N646_2398 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase N646_2399 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) N646_2400 ENOG4105E3R (LipO)protein N646_2405 ENOG4105DAY polysaccharide export protein N646_2410 ENOG4105CG5 Glycosyl transferase (Group 1 N646_2414 ENOG4108RYC glycosyltransferase N646_2417 ENOG4105ESV Glycosyl transferase, family 4 N646_2419 ENOG4107R4N Cell wall formation (By similarity) N646_2422 ENOG4105CPK Glycosyl transferase (Group 1 N646_2428 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase N646_2429 ENOG4105CP7 Triose-phosphate isomerase N646_2431 ENOG4108VTS Membrane N646_2436 ENOG4105CBT Fructose-1,6-bisphosphatase N646_2438 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) N646_2439 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) N646_2440 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase N646_2441 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) N646_2442 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) N646_2444 ENOG4105ETE Transcriptional regulator (LacI family N646_2445 ENOG4105C25 Primosomal protein n' N646_2446 ENOG4105VFB Binds the 23S rRNA (By similarity) N646_2447 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) N646_2448 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) N646_2449 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) N646_2450 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) N646_2451 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity N646_2452 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) N646_2453 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) N646_2454 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) N646_2455 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) N646_2456 ENOG41083MP 50s ribosomal protein l29 N646_2457 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal N646_2458 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) N646_2459 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) N646_2460 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits N646_2461 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) N646_2462 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) N646_2463 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) N646_2465 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) N646_2466 ENOG4105VPB 50S ribosomal protein L30 N646_2467 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) N646_2468 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) N646_2470 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits N646_2471 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) N646_2472 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) N646_2473 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) N646_2474 ENOG4108ZT0 50S ribosomal protein l17 N646_2476 ENOG4108V1T peptidylprolyl cis-trans isomerase N646_2478 ENOG4107YB6 acetyltransferase, (GNAT) family N646_2479 ENOG4105C1J atp-dependent rna helicase N646_2481 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic N646_2482 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) N646_2483 ENOG4105C11 sulfate adenylyltransferase), subunit 2 N646_2484 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) N646_2486 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) N646_2490 ENOG4108I0Y (ABC) transporter N646_2493 ENOG4108UUE Transcriptional regulator N646_2494 ENOG41061GZ Protein of unknown function (DUF1107) N646_2495 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) N646_2496 ENOG4105CFU surface antigen N646_2497 ENOG4105MA0 exported protein N646_2498 ENOG41066HZ AIG2-like family N646_2500 ENOG4105F0N pyrophosphate phospho-hydrolase N646_2501 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 N646_2503 ENOG4105DFU Cell wall formation (By similarity) N646_2504 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase N646_2505 ENOG4105DP9 ABC transporter N646_2506 ENOG4106SMU thiamine transporter membrane protein N646_2507 ENOG4107T0D ABC, transporter N646_2508 ENOG4105CC0 LysR family Transcriptional regulator N646_2509 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase N646_2513 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) N646_2514 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) N646_2516 ENOG4105EAH synthase N646_2517 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) N646_2518 ENOG4105K46 50S ribosomal protein l27 N646_2519 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control N646_2520 ENOG4105DWK Membrane N646_2521 ENOG4107XM3 UPF0442 protein N646_2522 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) N646_2523 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) N646_2524 ENOG4105NWN ApaG protein N646_2525 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) N646_2526 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) N646_2527 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) N646_2528 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) N646_2529 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) N646_2531 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) N646_2532 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) N646_2533 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) N646_2534 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) N646_2539 ENOG41064T2 transcriptional regulator, lysR family N646_2540 ENOG4108IQE Amp-dependent synthetase and ligase N646_2541 ENOG4105C7K acetolactate synthase N646_2542 ENOG4108ZP8 Acetolactate synthase small subunit N646_2543 ENOG4105BZU Histidine kinase N646_2545 ENOG4105CA9 Pyruvate kinase N646_2546 ENOG410804X Transcriptional regulator N646_2547 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) N646_2549 ENOG4105CMT Dihydroxyacetone kinase N646_2550 ENOG4108UTZ Dihydroxyacetone kinase N646_2553 ENOG4105E61 Mannitol repressor protein N646_2554 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase N646_2555 ENOG4105CTS PTS system mannitol-specific N646_2559 ENOG4105D01 (LipO)protein N646_2560 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) N646_2561 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) N646_2562 ENOG4105KTH gatB Yqey N646_2563 ENOG4105VCC 30S ribosomal protein S21 N646_2564 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) N646_2565 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) N646_2566 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) N646_2567 ENOG4107ZVW dihydroneopterin aldolase N646_2568 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase N646_2569 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) N646_2570 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate N646_2574 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) N646_2576 ENOG4106MWK domain protein N646_2577 ENOG4105CJ3 phosphate transporter N646_2578 ENOG4107IX6 phosphate transport regulator N646_2579 ENOG4105I7R Adenylate cyclase N646_2581 ENOG4105C8Q Methyl-accepting chemotaxis N646_2582 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) N646_2583 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) N646_2584 ENOG4105DFG type I secretion outer membrane protein N646_2585 ENOG41087AY ADP-Ribose pyrophosphatase N646_2586 ENOG4108SX3 cytoplasmic protein N646_2587 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) N646_2588 ENOG4105IPS esterase N646_2589 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) N646_2590 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) N646_2591 ENOG4105C0H protease N646_2592 ENOG4105C0H protease N646_2593 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III N646_2594 ENOG4105D6Z AFG1 family ATPase N646_2595 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) N646_2596 ENOG4108UJD 30S ribosomal protein S9 N646_2597 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) N646_2598 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) N646_2599 ENOG4105EIX cytochrome c1 N646_2600 ENOG4107MKT Stringent starvation protein a N646_2601 ENOG4105KB2 stringent starvation protein b N646_2602 ENOG4105W4M Transport-associated protein N646_2603 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) N646_2604 ENOG41082RQ UPF0102 protein N646_2606 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) N646_2607 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) N646_2608 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) N646_2609 ENOG4105CJN penicillin-binding protein N646_2610 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) N646_2611 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) N646_2612 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) N646_2613 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) N646_2615 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) N646_2616 ENOG4105DFU Cell wall formation (By similarity) N646_2617 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) N646_2618 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) N646_2619 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) N646_2620 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) N646_2622 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving N646_2623 ENOG4105M6F mutator MutT protein N646_2624 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) N646_2625 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain N646_2626 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain N646_2629 ENOG4105EJ9 Membrane N646_2630 ENOG4105EN6 Membrane N646_2631 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) N646_2632 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) N646_2633 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) N646_2635 ENOG4105BZ8 glutamate synthase N646_2636 ENOG4105CBC glutamate synthase N646_2639 ENOG4105N5T Radical SAM Protein N646_2641 ENOG4105BZU Histidine kinase N646_2643 ENOG41065U4 response regulator N646_2645 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) N646_2648 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) N646_2649 ENOG4105D98 threonine synthase N646_2651 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) N646_2652 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) N646_2653 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) N646_2656 ENOG4105BZG amino acid carrier protein N646_2657 ENOG4105D1Q UPF0246 protein N646_2658 ENOG4105C1J atp-dependent rna helicase N646_2659 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) N646_2660 ENOG4105CWM branched-chain amino acid transport system II carrier protein N646_2661 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) N646_2662 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) N646_2663 ENOG4105T95 Thiol disulfide interChange protein N646_2664 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) N646_2665 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) N646_2666 ENOG4105CRK lysyL-tRNA synthetase N646_2667 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family N646_2669 ENOG4105CPC Aldo Keto reductase N646_2671 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) N646_2673 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) N646_2674 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase N646_2675 ENOG4105HF0 Membrane N646_2676 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) N646_2677 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) N646_2680 ENOG41063Z6 transcriptional regulator, lysR family N646_2681 ENOG41080HT Transcriptional regulator, arsr family N646_2682 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) N646_2683 ENOG4105CJR Integral membrane protein (MviN N646_2684 ENOG4105DTN riboflavin biosynthesis protein ribF N646_2685 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) N646_2686 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) N646_2688 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase N646_2689 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) N646_2691 ENOG4108NEV two component transcriptional regulator, LytTR family N646_2692 ENOG4108HRK Histidine kinase N646_2696 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate N646_2697 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) N646_2698 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) N646_2699 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) N646_2700 ENOG4105EHE chorismate mutase- prephenate dehydrogenase N646_2701 ENOG4105DR5 peptidase N646_2703 ENOG4105C5H ABC transporter N646_2704 ENOG4107SC1 transglycosylase N646_2705 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) N646_2706 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) N646_2710 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA N646_2711 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) N646_2712 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane N646_2713 ENOG4105C34 Pseudouridine synthase N646_2714 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase N646_2715 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit N646_2721 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding N646_2722 ENOG4105CFP Peptidase U32 N646_2723 ENOG4105DH7 May be involved in recombination (By similarity) N646_2724 ENOG4105CK6 Two component transcriptional regulator (Winged helix family N646_2725 ENOG4105BZU Histidine kinase N646_2727 ENOG4108RS6 transposase N646_2728 ENOG4105C9X ppx gppa phosphatase N646_2729 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) N646_2730 ENOG4105C8U phosphate abc transporter N646_2731 ENOG4105E2Z phosphate ABC transporter (Permease N646_2732 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) N646_2734 ENOG4105CSR polyphosphate kinase 2 N646_2735 ENOG4106N3A copper homeostasis protein cutc N646_2737 ENOG4105D3R alkyl hydroperoxide reductase N646_2738 ENOG4105C5Q Transcriptional regulator N646_2740 ENOG4107QP3 malate synthase g N646_2741 ENOG4108I9X Isocitrate lyase N646_2742 ENOG4105W87 Cbs domain N646_2744 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) N646_2745 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) N646_2746 ENOG4105VIE preprotein translocase, subunit YajC N646_2747 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) N646_2748 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) N646_2751 ENOG4105ECY inositol monophosphatase N646_2752 ENOG4105CVS RNA methyltransferase TrmH family, group 1 N646_2753 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family N646_2754 ENOG4105C3J Cysteine desulfurase N646_2755 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins N646_2756 ENOG4108Z4V iron-sulfur cluster assembly N646_2757 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) N646_2758 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB N646_2759 ENOG4108ZIT Ferredoxin, 2FE-2S N646_2760 ENOG4105WVQ Fe-S assembly protein IscX N646_2761 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) N646_2762 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) N646_2763 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs N646_2765 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) N646_2766 ENOG4105CUT histidyl-tRNA synthetase N646_2767 ENOG4105N21 Membrane N646_2768 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) N646_2769 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) N646_2771 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) N646_2772 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) N646_2773 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) N646_2774 ENOG4107S6Z Na H antiporter N646_2776 ENOG4106HK8 GPR1 FUN34 yaaH family protein N646_2777 ENOG4105BZG amino acid carrier protein N646_2778 ENOG4105MWK D-amino acid dehydrogenase, small subunit N646_2780 ENOG4108IQK o-acetylhomoserine N646_2781 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) N646_2785 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase N646_2786 ENOG4105ETT transcriptional Regulator, LysR family N646_2794 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) N646_2796 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) N646_2797 ENOG4108Z1B Cyclase dehydrase N646_2798 ENOG4105VDB UPF0125 protein N646_2799 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) N646_2801 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) N646_2803 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) N646_2804 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ N646_2805 ENOG4105CK2 sodium dicarboxylate symporter N646_2806 ENOG4105CFG Acts as a chaperone (By similarity) N646_2807 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) N646_2813 ENOG4105CFC Transporter N646_2814 ENOG4108Z6B deaminase N646_2816 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) N646_2817 ENOG4108ETH Formylglycinamide ribotide synthetase N646_2824 ENOG4105CIN aminoacyl-histidine dipeptidase N646_2825 ENOG4105C7N Xanthine uracil vitamin C permease N646_2826 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) N646_2827 ENOG4108DJV Fermentation respiration switch protein N646_2828 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) N646_2829 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) N646_2830 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) N646_2831 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) N646_2832 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) N646_2835 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) N646_2836 ENOG4107YIM Involved in the transcription termination process (By similarity) N646_2837 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) N646_2838 ENOG4108ZAI phosphatidylglycerophosphatase a N646_2839 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) N646_2840 ENOG4105CTB Polyprenyl synthetase N646_2841 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) N646_2842 ENOG4105E14 MotA TolQ exbB proton channel N646_2843 ENOG4106VK6 Flagellar motor protein N646_2844 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) N646_2845 ENOG4105ETT transcriptional Regulator, LysR family N646_2847 ENOG4105M08 Membrane N646_2848 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) N646_2851 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease N646_2852 ENOG4105EWT decarboxylase family N646_2853 ENOG4105BZU Histidine kinase N646_2855 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) N646_2857 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) N646_2858 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein N646_2859 ENOG4105D01 (LipO)protein N646_2860 ENOG4108UMI ABC transporter, permease N646_2861 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) N646_2862 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase N646_2863 ENOG4105D4X repressor N646_2864 ENOG4105C5Y PTS System N646_2865 ENOG4105CG3 alpha amylase, catalytic region N646_2868 ENOG4108JYZ YitT family N646_2869 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) N646_2870 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) N646_2871 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) N646_2872 ENOG4108Z43 UPF0250 protein N646_2873 ENOG4105DZ1 carboxypeptidase N646_2874 ENOG4105K6T rare lipoprotein A N646_2875 ENOG4105CNI cell division protein FtsW N646_2876 ENOG4105CJN penicillin-binding protein N646_2877 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) N646_2878 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) N646_2879 ENOG4105DJF DNA polymerase III, delta' subunit N646_2880 ENOG4108U2H Rare lipoprotein B N646_2881 ENOG4105C8T Leucyl-tRNA synthetase N646_2882 ENOG4107PAI alpha helical protein N646_2883 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) N646_2884 ENOG4108JU5 Magnesium and cobalt efflux protein N646_2885 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) N646_2886 ENOG4105C9A Phoh family N646_2887 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) N646_2888 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family N646_2889 ENOG4105C3G gtp-binding protein N646_2890 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) N646_2891 ENOG4105C5T Phosphoribosyl pyrophosphate synthase N646_2892 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) N646_2893 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) N646_2894 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) N646_2895 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) N646_2896 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) N646_2897 ENOG4108YY7 Invasion gene expression up-regulator SirB N646_2898 ENOG41063JG Transcriptional regulator N646_2899 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase N646_2900 ENOG4105CGH 5'-nucleotidase N646_2901 ENOG4108Z66 YbaK ebsC protein N646_2902 ENOG4105FE9 pseudouridine synthase N646_2903 ENOG4108DG9 Smr protein MutS2 N646_2906 ENOG4105E2D ec 3.2.1.52 N646_2909 ENOG4105C59 p-type ATPase N646_2910 ENOG41081QG Porin Gram-negative type N646_2912 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) N646_2913 ENOG4105UYK outer membrane protein a N646_2922 ENOG4107R88 Chemotaxis protein (CheV) N646_2923 ENOG4105BZU Histidine kinase N646_2924 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) N646_2925 ENOG4108ZC9 flagellar basal-body rod protein flgc N646_2926 ENOG4105W00 Flagellar hook capping protein N646_2927 ENOG4105BZE flagellar hook protein, FlgE N646_2929 ENOG4108KPB Flagellar basal-body rod protein FlgF N646_2930 ENOG4105CGA flagellar basal-body rod protein FlgG N646_2931 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) N646_2932 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) N646_2933 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj N646_2935 ENOG4105DTJ flagellar hook-associated protein N646_2936 ENOG4105I03 Flagellin N646_2937 ENOG4105I03 Flagellin N646_2939 ENOG4105C5Y PTS System N646_2940 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) N646_2941 ENOG4105KZ7 phosphocarrier protein hpr N646_2942 ENOG4105C6T cysteine synthase N646_2943 ENOG4105EXN Sulfate transport protein CysZ N646_2944 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) N646_2945 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) N646_2949 ENOG4107QX8 SPFH domain, Band 7 family protein N646_2950 ENOG4105D1V cellulose synthase operon protein YhjU N646_2952 ENOG4105U74 cellulose biosynthesis protein BcsE N646_2954 ENOG4105UTS cellulose synthase operon protein YhjQ N646_2956 ENOG4107QZ7 Cellulose synthase catalytic subunit N646_2957 ENOG4107EEX Cellulose synthase regulator protein N646_2958 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) N646_2959 ENOG4105EJG cellulose synthase N646_2960 ENOG4107QR8 Thioredoxin N646_2961 ENOG4105E1F short-chain dehydrogenase reductase N646_2962 ENOG4105ECP epimerase N646_2967 ENOG4108RE9 Phosphodiesterase N646_2971 ENOG4108DQ1 activator toxR N646_2972 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) N646_2974 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) N646_2975 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) N646_2976 ENOG4105DUX Transporter N646_2977 ENOG4105MDZ Transcriptional activator rfaH N646_2978 ENOG4105CAQ asparagine synthetase N646_2980 ENOG4105CKD glutathione-regulated potassium-efflux system protein N646_2981 ENOG4105E2R ROK family N646_2982 ENOG4105CE4 GlcNAc 6-P deacetylase N646_2983 ENOG4105CI1 PTS System N646_2984 ENOG4105CX6 glutaminyL-tRNA synthetase N646_2985 ENOG41090R7 Ferric uptake N646_2987 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) N646_2989 ENOG4105EV9 Alpha Beta Hydrolase N646_2990 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) N646_2991 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 N646_2993 ENOG4107QNR UPF0135 protein N646_2994 ENOG4105BZN citrate synthase N646_2995 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit N646_2996 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein N646_2997 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) N646_2998 ENOG4105E33 succinate dehydrogenase N646_2999 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 N646_3000 ENOG4105C7S Dehydrogenase N646_3001 ENOG4105CMV Succinyl-CoA synthetase subunit beta N646_3002 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha N646_3003 ENOG4105FAV ABC, transporter N646_3004 ENOG4105FDK ABC transporter N646_3005 ENOG4105NXV High-affinity zinc uptake system protein N646_3006 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) N646_3007 ENOG4105XFK Ferrous iron transport protein A N646_3012 ENOG4105C75 arginyL-tRNA synthetase N646_3013 ENOG4106ZCM YecM protein N646_3015 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap N646_3016 ENOG4105CIY formyltetrahydrofolate deformylase N646_3018 ENOG4105DVT helicase N646_3019 ENOG41072GX Peptidase M22 Glycoprotease N646_3021 ENOG4105R8X Outer membrane lipoprotein Slp N646_3022 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) N646_3023 ENOG4105CEY Amp-dependent synthetase and ligase N646_3024 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) N646_3025 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) N646_3026 ENOG4107QMS site-determining protein N646_3027 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) N646_3028 ENOG4105VNG YcgL domain-containing protein N646_3029 ENOG4105CVE Lytic murein transglycosylase N646_3031 ENOG4105D9N nucleoside N646_3032 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) N646_3033 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) N646_3034 ENOG4105C2D reductase N646_3035 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) N646_3036 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) N646_3041 ENOG4105C84 Histidine ammonia-lyase N646_3042 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) N646_3043 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) N646_3047 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) N646_3054 ENOG4105C1J atp-dependent rna helicase N646_3055 ENOG4107ZYR domain protein N646_3059 ENOG4105CNG UPF0061 protein N646_3060 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit N646_3061 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ N646_3062 ENOG4105CG6 trap dicarboxylate transporter dctm subunit N646_3064 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family N646_3065 ENOG4105CQZ Histidine kinase N646_3066 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation N646_3067 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) N646_3068 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) N646_3069 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) N646_3070 ENOG4105K70 DNA-binding protein N646_3071 ENOG4105EIN peptidylprolyl cis-trans isomerase N646_3072 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein N646_3075 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein N646_3076 ENOG4105DK2 UPF0207 protein N646_3077 ENOG4105CHM Aminotransferase N646_3078 ENOG4107R88 Chemotaxis protein (CheV) N646_3080 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related N646_3081 ENOG41090JE Utilization Protein N646_3082 ENOG4105D4P Coproporphyrinogen iii oxidase N646_3083 ENOG4105WQ5 TonB family N646_3084 ENOG41090AP transport protein N646_3085 ENOG4106GFD transport protein N646_3087 ENOG4105EHG Permease protein N646_3088 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) N646_3096 ENOG4107X4V Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) N646_3097 ENOG4107RA1 nh(3)-dependent nad( ) synthetase N646_3098 ENOG4105QVC MOSC domain-containing protein N646_3098 ENOG4105QVC MOSC domain-containing protein N646_3100 ENOG4105EKE dihydroorotase N646_3101 ENOG4105CKW Inner membrane protein yedI N646_3108 ENOG4108JJ8 (ABC) transporter N646_3114 ENOG4105EG2 ABC transporter, permease N646_3115 ENOG4105D56 permease protein N646_3116 ENOG4107FKK extracellular solute-binding protein family 1 N646_3117 ENOG4108IJ9 (ABC) transporter N646_3118 ENOG4105D3Q Sugar transferase N646_3121 ENOG4108F2G Chain length determinant protein N646_3130 ENOG4105V0I UPF0267 protein N646_3131 ENOG4108WUH Transcriptional regulator, TetR family N646_3132 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein N646_3133 ENOG4108RXX maleylacetoacetate isomerase N646_3134 ENOG4105CH6 catalase N646_3135 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase N646_3141 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 N646_3144 ENOG4105CJP fad dependent oxidoreductase N646_3145 ENOG4107QZF nitrite reductase NADPH large subunit N646_3146 ENOG4105C26 Dehydrogenase N646_3147 ENOG4105DVW rieske (2Fe-2S) N646_3151 ENOG4105ETT transcriptional Regulator, LysR family N646_3152 ENOG4105CZN Potassium uptake protein N646_3156 ENOG4105BZ1 (ABC) transporter N646_3157 ENOG4105E0K tonB-dependent siderophore receptor N646_3158 ENOG4105E0A ABC, transporter N646_3159 ENOG4108HUF Transporter N646_3160 ENOG4105S6R Iron-hydroxamate transporter permease subunit N646_3163 ENOG4108JJ6 Type I secretion system ATPase N646_3165 ENOG41086KC Transcriptional regulator N646_3166 ENOG41086KC Transcriptional regulator N646_3168 ENOG4105C8Q Methyl-accepting chemotaxis N646_3169 ENOG4105C7R Atpase associated with various cellular activities aaa_3 N646_3177 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) N646_3178 ENOG4105E2Z phosphate ABC transporter (Permease N646_3179 ENOG4105C8U phosphate abc transporter N646_3180 ENOG4107S17 Phosphate-binding protein N646_3181 ENOG4108NVR Methyl-accepting chemotaxis N646_3185 ENOG4107ENK receptor N646_3186 ENOG4105CUG Oligopeptidase b N646_3187 ENOG4105C1J atp-dependent rna helicase N646_3189 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein N646_3190 ENOG4105CVP deoxyribo-dipyrimidine photolyase N646_3191 ENOG4108XDN Transcriptional regulator N646_3192 ENOG4107SEY Conserved Protein N646_3193 ENOG4105D3A purine nucleoside phosphorylase DeoD-type N646_3196 ENOG4106TD9 Diguanylate cyclase N646_3197 ENOG4105KK7 inner membrane protein YiaW N646_3198 ENOG4105EFX secretion protein, HlyD family N646_3199 ENOG4108V7D UPF0397 protein N646_3200 ENOG4108JJB ABC transporter N646_3201 ENOG4108JJB ABC transporter N646_3205 ENOG4105GXZ Ferredoxin-type protein NapH N646_3206 ENOG4108BGM Quinol dehydrogenase periplasmic component N646_3207 ENOG4105WCN acetyltransferase N646_3210 ENOG4105YE1 PilZ domain N646_3211 ENOG4107QE9 Inherit from COG: Membrane N646_3213 ENOG4105DAN ATP-dependent protease N646_3215 ENOG4108JQ5 ABC transporter N646_3217 ENOG410642W LysR family Transcriptional regulator N646_3218 ENOG4105DAA L-lactate N646_3219 ENOG4105DMF Dehydrogenase N646_3221 ENOG4105D64 Mechanosensitive ion channel N646_3228 ENOG4105CPQ Dehydrogenase N646_3229 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) N646_3230 ENOG4105BZU Histidine kinase N646_3231 ENOG4105E89 ABC transporter N646_3233 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) N646_3235 ENOG4105DPZ Two component transcriptional regulator (Winged helix family N646_3239 ENOG4105EXG Transcriptional regulator N646_3240 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase N646_3245 ENOG4107SSZ Phosphatase N646_3251 ENOG4108JIR Flagellum-specific ATP synthase N646_3253 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) N646_3254 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) N646_3256 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family N646_3259 ENOG4105DD5 Flagellar motor switch protein N646_3260 ENOG4105CN7 Flagellar biosynthetic protein FliP N646_3261 ENOG4105VS8 Flagellar biosynthetic protein fliq N646_3262 ENOG4105D19 Role in flagellar biosynthesis (By similarity) N646_3263 ENOG4105D00 flagellar biosynthetic protein flhB N646_3266 ENOG4105I03 Flagellin N646_3267 ENOG410804A Flagellar hook-associated 2 domain-containing protein N646_3268 ENOG4105MQ3 flagellar protein FliS N646_3273 ENOG4107RD7 Flagellar Motor Protein, MotA N646_3274 ENOG4105ER2 Ompa motb domain protein N646_3276 ENOG4105KWG Pfam:DUF1696 N646_3280 ENOG4105C6N Formate acetyltransferase N646_3281 ENOG4105F1A Pyruvate formate-lyase N646_3282 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) N646_3286 ENOG4105EB3 Histidine kinase N646_3287 ENOG4105E3W Two component transcriptional regulator (Winged helix family N646_3289 ENOG4105I4A GCN5-related N-acetyltransferase N646_3291 ENOG4105CNH Multidrug resistance protein MdtL N646_3292 ENOG4105G2Y Transcriptional regulator N646_3300 ENOG4105IPI Membrane N646_3301 ENOG41068P6 UPF0319 protein N646_3303 ENOG4105DP0 ferredoxin-NADP reductase N646_3305 ENOG4105VYA Uncharacterized conserved protein (DUF2132) N646_3306 ENOG4105ETT transcriptional Regulator, LysR family N646_3308 ENOG4108RCM Nitroreductase N646_3309 ENOG4108ZX5 transcriptional regulator N646_3312 ENOG4105DZ1 carboxypeptidase N646_3314 ENOG4105C72 UPF0176 protein N646_3316 ENOG4105CVP deoxyribo-dipyrimidine photolyase N646_3318 ENOG4108M1A Chitin-binding protein N646_3319 ENOG4108NRW Phospholipase, patatin family N646_3320 ENOG41081FY multiple antibiotic resistance (MarC)-related N646_3324 ENOG4105DAY polysaccharide export protein N646_3325 ENOG4105KJF protein tyrosine phosphatase N646_3328 ENOG4105N0V mono-oxygenase ydhR N646_3329 ENOG4105F04 LysR family Transcriptional regulator N646_3331 ENOG4105CK2 sodium dicarboxylate symporter N646_3334 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) N646_3335 ENOG4108P2H Inner membrane protein YjiG N646_3336 ENOG41074DU domain protein N646_3339 ENOG4107T9C Alpha amylase catalytic region N646_3340 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase N646_3341 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) N646_3342 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) N646_3343 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) N646_3344 ENOG41061ZR Transcriptional regulator N646_3349 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) N646_3350 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) N646_3351 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) N646_3355 ENOG4108K8S endonuclease I N646_3359 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) N646_3361 ENOG4105EJQ L-serine dehydratase N646_3363 ENOG4105D2S major facilitator superfamily N646_3368 ENOG4105CHR reductase N646_3369 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) N646_3370 ENOG4105CNV Aldolase N646_3371 ENOG4105ETE Transcriptional regulator (LacI family N646_3372 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit N646_3374 ENOG4105CG6 trap dicarboxylate transporter dctm subunit N646_3377 ENOG4107RJ1 sodium solute N646_3378 ENOG4105ETE Transcriptional regulator (LacI family N646_3380 ENOG4105E5M Multidrug resistance protein D N646_3383 ENOG4105DR5 peptidase N646_3385 ENOG4107RAN Peptidase, M16 N646_3386 ENOG4105C8Q Methyl-accepting chemotaxis N646_3387 ENOG4105E0A ABC, transporter N646_3388 ENOG4108U1V ABC transporter, permease N646_3389 ENOG4105DQ5 transport system permease protein N646_3390 ENOG4108HUF Transporter N646_3391 ENOG4105GAV receptor N646_3392 ENOG4105E0K tonB-dependent siderophore receptor N646_3394 ENOG4105DUU IucA IucC family protein N646_3396 ENOG4105DBM Siderophore biosynthesis protein N646_3397 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) N646_3401 ENOG4105C19 ABC transporter N646_3409 ENOG4108ZHJ Organic hydroperoxide resistance protein N646_3410 ENOG4105K56 Transcriptional regulator N646_3412 ENOG4105D3R alkyl hydroperoxide reductase N646_3413 ENOG4108JU3 Alkyl hydroperoxide reductase N646_3417 ENOG4105ECQ AraC Family Transcriptional Regulator N646_3422 ENOG4108RPX mosc domain containing protein N646_3423 ENOG4105C1J atp-dependent rna helicase N646_3426 ENOG4105BZ1 (ABC) transporter N646_3429 ENOG4105EW9 transcriptional regulator AsnC family N646_3435 ENOG4105CK7 Sodium proline symporter N646_3437 ENOG4105C26 Dehydrogenase N646_3440 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) N646_3441 ENOG4105CQZ Histidine kinase N646_3442 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family N646_3443 ENOG4107QZV Type I secretion membrane fusion protein N646_3446 ENOG4108JJA ABC, transporter N646_3452 ENOG4108J59 Extracellular solute-binding protein, family 5 N646_3454 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) N646_3455 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate N646_3456 ENOG4105C5Y PTS System N646_3457 ENOG4105FCK Membrane N646_3458 ENOG4105EC3 peptidase S51, dipeptidase E N646_3462 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) N646_3467 ENOG4108JQ7 (ABC) transporter N646_3472 ENOG4105BZU Histidine kinase N646_3474 ENOG4105CDY transcriptional regulatory protein N646_3475 ENOG4105CNI cell division protein FtsW N646_3481 ENOG4108HRK Histidine kinase N646_3482 ENOG4108VAC response regulator N646_3483 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) N646_3484 ENOG4105C8Q Methyl-accepting chemotaxis N646_3487 ENOG4105D6U Sodium Glutamate Symporter N646_3489 ENOG4105CZV ABC transporter N646_3491 ENOG4105D6U Sodium Glutamate Symporter N646_3493 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) N646_3497 ENOG4105C2I pirin domain protein N646_3498 ENOG4108VGI doxx family N646_3500 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) N646_3501 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) N646_3505 ENOG4105DN9 Na H antiporter N646_3509 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) N646_3512 ENOG4105NBK UPF0345 protein N646_3514 ENOG4108K0B C-di-gmp phosphodiesterase N646_3515 ENOG4105UQX Mate efflux family protein N646_3516 ENOG4105D3G Pseudouridine synthase N646_3519 ENOG4105EJC lysr family transcriptional regulator N646_3520 ENOG4108HCJ Hydrolase N646_3522 ENOG4108KHX Diguanylate cyclase N646_3524 ENOG4105C4W S-formylglutathione hydrolase N646_3526 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase N646_3527 ENOG4105CC0 LysR family Transcriptional regulator N646_3528 ENOG4105Q26 Siderophore-interacting protein N646_3530 ENOG4105EW9 transcriptional regulator AsnC family N646_3531 ENOG4108M1A Chitin-binding protein N646_3534 ENOG4107W31 Pentapeptide repeat protein N646_3536 ENOG4105EIF outer membrane protein W N646_3538 ENOG4105C0R drug resistance transporter emrb qaca subfamily N646_3541 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase N646_3548 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR N646_3549 ENOG4105C6Z Gluconate N646_3550 ENOG4105BZW Glycerate kinase N646_3551 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family N646_3558 ENOG4105CYX Short-chain dehydrogenase reductase Sdr N646_3559 ENOG41068WN N646_3560 ENOG4105CUW cytochrome C-TYPE protein N646_3561 ENOG4107QY8 reductase N646_3563 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) N646_3564 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase N646_3565 ENOG4105ETU transcriptional activator (TenA N646_3566 ENOG4107Z6I Thiamine biosynthesis protein N646_3567 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component N646_3568 ENOG4108YI8 ABC transporter N646_3569 ENOG4105DWF phosphomethylpyrimidine kinase N646_3572 ENOG4108TEM pseudouridine methyltransferase N646_3578 ENOG4108YYI Protein of unknown function (DUF2810) N646_3579 ENOG4105C5I Dehydrogenase N646_3581 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase N646_3582 ENOG4105E3W Two component transcriptional regulator (Winged helix family N646_3583 ENOG410804D Sensor Signal Transduction Histidine Kinase N646_3588 ENOG4109015 Biopolymer transport protein exbD tolR N646_3596 ENOG4105DSE periplasmic solute binding protein N646_3597 ENOG4105DIK (ABC) transporter N646_3598 ENOG4105CC5 ABC transporter N646_3601 ENOG4105CUG Oligopeptidase b N646_3602 ENOG4105E5M Multidrug resistance protein D N646_3603 ENOG4105CYW agmatinase N646_3604 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) N646_3606 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) N646_3607 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) N646_3611 ENOG4105DUM transcriptional regulator, lysR family N646_3617 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family N646_3618 ENOG4105BZU Histidine kinase N646_3619 ENOG4105CWM branched-chain amino acid transport system II carrier protein N646_3623 ENOG4105D5U fad dependent oxidoreductase N646_3626 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii N646_3627 ENOG4105C4M (Ubiquinol oxidase) subunit I N646_3628 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) N646_3629 ENOG4105C0F tryptophanase EC 4.1.99.1 N646_3632 ENOG4105D9N nucleoside N646_3635 ENOG4105BZU Histidine kinase N646_3638 ENOG4106TD9 Diguanylate cyclase N646_3639 ENOG4105CVP deoxyribo-dipyrimidine photolyase N646_3640 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein N646_3642 ENOG4105E0X reductase N646_3643 ENOG4108UKZ OsmC family N646_3644 ENOG4108UW5 maltose o-acetyltransferase N646_3651 ENOG4105JQN Transcriptional regulator N646_3652 ENOG4105PAD Hydrolase N646_3655 ENOG4108UUE Transcriptional regulator N646_3657 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation N646_3659 ENOG4105DJY efflux transporter, rnd family, mfp subunit N646_3660 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) N646_3663 ENOG4105MKU Transcriptional regulator N646_3664 ENOG4105KUU lipolytic protein G-D-S-L family N646_3665 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin N646_3667 ENOG4108KAZ Involved in phosphonate degradation (By similarity) N646_3668 ENOG4108JPW Aminotransferase N646_3669 ENOG4107STF Involved in phosphonate degradation (By similarity) N646_3672 ENOG4107RCV ABC transporter, permease N646_3676 ENOG4108MJ5 VirK protein N646_3679 ENOG4105CJP fad dependent oxidoreductase N646_3682 ENOG4105UYK outer membrane protein a N646_3683 ENOG4105ETT transcriptional Regulator, LysR family N646_3686 ENOG4105EJQ L-serine dehydratase N646_3690 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) N646_3691 ENOG4105E9H Lytic Murein transglycosylase N646_3695 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) N646_3696 ENOG4108ZC9 flagellar basal-body rod protein flgc N646_3697 ENOG4105W00 Flagellar hook capping protein N646_3698 ENOG4105BZE flagellar hook protein, FlgE N646_3699 ENOG4108KPB Flagellar basal-body rod protein FlgF N646_3700 ENOG4105CGA flagellar basal-body rod protein FlgG N646_3701 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) N646_3702 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) N646_3703 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj N646_3704 ENOG4105E1Q flagellar hook-associated protein N646_3705 ENOG4105DTJ flagellar hook-associated protein N646_3709 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) N646_3713 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) N646_3714 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) N646_3715 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) N646_3717 ENOG4105N14 lysine exporter protein LysE YggA N646_3721 ENOG4107Z3H Transcriptional regulator, TetR family N646_3722 ENOG4108K3Z AraC family transcriptional regulator N646_3724 ENOG4105CPD ethanolamine ammonia-lyase N646_3725 ENOG4107FQ9 ethanolamine ammonia-lyase N646_3726 ENOG4105CUB amino acid N646_3727 ENOG4105EA8 2-Nitropropane dioxygenase N646_3728 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) N646_3729 ENOG4105N2W Transcriptional regulator N646_3732 ENOG4108RWI nicotinamidase N646_3735 ENOG4107RH7 Nicotinate phosphoribosyltransferase N646_3740 ENOG4105ETT transcriptional Regulator, LysR family N646_3744 ENOG4105RW8 MltA-interacting MipA family protein N646_3745 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion N646_3746 ENOG4108IJ7 Glycine betaine N646_3747 ENOG4107U14 binding-protein-dependent transport systems inner membrane Component N646_3749 ENOG4105VYW UPF0251 protein N646_3754 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) N646_3755 ENOG4107S8C mandelate racemase muconate lactonizing N646_3757 ENOG4105RQF LysR family Transcriptional regulator N646_3759 ENOG4108Z4X TRANSCRIPTIONal N646_3764 ENOG4107RZC phospholipase d N646_3766 ENOG4105BZS acriflavin resistance protein N646_3770 ENOG4105BZS acriflavin resistance protein N646_3774 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) N646_3784 ENOG4107RUE extracellular solute-binding protein family 1 N646_3785 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) N646_3786 ENOG4105WH1 Two component transcriptional regulator luxr family N646_3789 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) N646_3790 ENOG4105HDK L-asparaginase N646_3791 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis N646_3795 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme N646_3797 ENOG4105C8Y Acetylornithine aminotransferase N646_3798 ENOG4105C26 Dehydrogenase N646_3799 ENOG4108RYR transcriptional regulator AsnC family N646_3800 ENOG4105E5N succinylglutamate desuccinylase aspartoacylase N646_3801 ENOG4105ENR peptidase, M24 N646_3802 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family N646_3804 ENOG4105CHR reductase N646_3806 ENOG4105CPQ Dehydrogenase N646_3807 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase N646_3810 ENOG4107RSM transcriptional regulator N646_3812 ENOG4105C1J atp-dependent rna helicase N646_3817 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family N646_3818 ENOG410874W AraC family transcriptional regulator N646_3819 ENOG4105HEI LysR family (Transcriptional regulator N646_3820 ENOG4105E1F short-chain dehydrogenase reductase N646_3823 ENOG4108P3C N646_3826 ENOG4105CHR reductase N646_3827 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin N646_3828 ENOG41064T2 transcriptional regulator, lysR family N646_3829 ENOG4105D05 Receptor N646_3833 ENOG4105C5Y PTS System N646_3834 ENOG4105D7K pfkb domain protein N646_3835 ENOG4108HKT sucrose-6-phosphate hydrolase N646_3836 ENOG4105CYM Glutathione S-transferase N646_3837 ENOG4105DZ1 carboxypeptidase N646_3839 ENOG4105EHV domain protein N646_3840 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) N646_3843 ENOG4105VEQ Cold shock protein N646_3844 ENOG4105EUB pirin domain protein N646_3845 ENOG4108NRW Phospholipase, patatin family N646_3847 ENOG4105EP9 oxidoreductase N646_3848 ENOG4105DIJ Phosphoethanolamine transferase N646_3849 ENOG41080IJ Diacylglycerol kinase N646_3851 ENOG4105E0F Histidine kinase N646_3852 ENOG4107EXC regulatoR N646_3855 ENOG4108Z33 Thiol disulfide Interchange Protein N646_3859 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) N646_3861 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) N646_3863 ENOG4105EST Metal Dependent Phosphohydrolase N646_3864 ENOG4105DZC cytosine deaminase N646_3865 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin N646_3867 ENOG4105CJW magnesium transporter N646_3868 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) N646_3869 ENOG4105EFX secretion protein, HlyD family N646_3875 ENOG4105CK6 Two component transcriptional regulator (Winged helix family N646_3876 ENOG4105E0F Histidine kinase N646_3879 ENOG4105DVH amino acid N646_3881 ENOG4105DUM transcriptional regulator, lysR family N646_3886 ENOG4105BZU Histidine kinase N646_3888 ENOG41090HJ UPF0265 protein N646_3890 ENOG4108YXG UPF0502 protein N646_3891 ENOG41082IR Excinuclease ABC C subunit domain protein N646_3892 ENOG4108QGH periplasmic N646_3893 ENOG4105BZU Histidine kinase N646_3894 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) N646_3895 ENOG4105J12 Multidrug resistance protein mdtN N646_3899 ENOG4105EW9 transcriptional regulator AsnC family N646_3904 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) N646_3905 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) N646_3909 ENOG4105CHU acetyl-coa acetyltransferase N646_3911 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class N646_3915 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) N646_3918 ENOG4105BZU Histidine kinase N646_3919 ENOG4105WH1 Two component transcriptional regulator luxr family N646_3922 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) N646_3923 ENOG4107YWA deoxycytidylate deaminase N646_3926 ENOG4108N3W hemolysin secretion protein N646_3927 ENOG4108YZN class I peptide chain release factor N646_3928 ENOG4107VXZ Hydrolase N646_3929 ENOG4105UYK outer membrane protein a N646_3930 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) N646_3931 ENOG4105DXI Major Facilitator superfamily N646_3933 ENOG4105CV1 Transketolase (EC 2.2.1.1) N646_3934 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) N646_3938 ENOG4105KHC sulfurtransferase N646_3941 ENOG4105D06 uba thif-type nad fad binding protein N646_3942 ENOG4105CVM Molybdenum cofactor synthesis domain protein N646_3943 ENOG4105EUJ GTP cyclohydrolase i N646_3945 ENOG4105CMQ Chloride channel N646_3950 ENOG4107RGM aldo keto reductase N646_3951 ENOG4108UNF response regulator N646_3953 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) N646_3954 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) N646_3955 ENOG4107QHE Choloylglycine hydrolase N646_3967 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family N646_3970 ENOG4105DR5 peptidase N646_3976 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family N646_3977 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit N646_3978 ENOG4108WC9 type VI secretion system effector, hcp1 family N646_3979 ENOG4105CS6 Rhs element vgr protein N646_3984 ENOG4105D9P serine threonine protein kinase N646_3991 ENOG4105EW9 transcriptional regulator AsnC family N646_4004 ENOG4105C2C drug resistance transporter, Bcr CflA N646_4006 ENOG4105HEI LysR family (Transcriptional regulator N646_4007 ENOG4105EMU Dehydrogenase N646_4008 ENOG4105Q9Y Universal stress protein N646_4010 ENOG4105D65 subunit l N646_4011 ENOG4105MKQ Monovalent cation H antiporter subunit C N646_4012 ENOG4108JPZ Monovalent cation H antiporter subunit D N646_4013 ENOG4105SC1 monovalent cation H antiporter subunit E N646_4014 ENOG41080TA Multiple resistance and ph regulation protein f N646_4015 ENOG4105KJM monovalent cation h antiporter subunit g N646_4016 ENOG4105FDP GntR family transcriptional regulator N646_4017 ENOG4105F8D glycoside hydrolase family 4 N646_4018 ENOG4105CI1 PTS System N646_4019 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) N646_4020 ENOG4105C10 Electron transfer flavoprotein N646_4021 ENOG4105BZJ Electron transfer flavoprotein N646_4022 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase N646_4024 ENOG4105C0Z ABC transporter N646_4025 ENOG4108IQE Amp-dependent synthetase and ligase N646_4029 ENOG4108IV0 ABC, transporter N646_4030 ENOG4105DZS Phenylacetate-CoA ligase N646_4031 ENOG4105FQ6 thiopurine methyltransferase N646_4032 ENOG4105CHR reductase N646_4033 ENOG4105C7K acetolactate synthase N646_4034 ENOG4107FQX Alpha-acetolactate decarboxylase N646_4036 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 N646_4039 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii N646_4040 ENOG4105C4M (Ubiquinol oxidase) subunit I N646_4041 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family N646_4042 ENOG4108UW5 maltose o-acetyltransferase N646_4044 ENOG4105EGS Mechanosensitive ion channel N646_4046 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase N646_4047 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase N646_4048 ENOG4108IPT Naphthoate synthase N646_4049 ENOG4107QX3 carboxylase N646_4050 ENOG4105C1G acyl-Coa dehydrogenase N646_4052 ENOG4105CHU acetyl-coa acetyltransferase N646_4053 ENOG4105C26 Dehydrogenase N646_4054 ENOG4105C1G acyl-Coa dehydrogenase N646_4055 ENOG4105E39 Enoyl-CoA hydratase N646_4057 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase N646_4059 ENOG4105BZU Histidine kinase N646_4060 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) N646_4061 ENOG4105C26 Dehydrogenase N646_4062 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) N646_4064 ENOG4108HQS Glycine betaine N646_4065 ENOG4108IJ7 Glycine betaine N646_4067 ENOG4108RCM Nitroreductase N646_4070 ENOG4107QX8 SPFH domain, Band 7 family protein N646_4073 ENOG4105CA0 peroxidase N646_4074 ENOG4105BZU Histidine kinase N646_4076 ENOG4105D82 Glutamate dehydrogenase N646_4087 ENOG4108K0B C-di-gmp phosphodiesterase N646_4088 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) N646_4089 ENOG4105C2J ABC transporter N646_4090 ENOG4105CNN ABC, transporter N646_4091 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator N646_4092 ENOG4108RVA ribokinase N646_4093 ENOG4105ETE Transcriptional regulator (LacI family N646_4095 ENOG4106Z1T Nicotinamide Mononucleotide Transporter N646_4096 ENOG4108I5U Uridine phosphorylase N646_4099 ENOG4105DHS permease protein N646_4100 ENOG4105CM4 permease protein N646_4101 ENOG4108IPW abc transporter atp-binding protein N646_4102 ENOG4108Z6Z Transcriptional regulator N646_4110 ENOG4105EM2 membrane N646_4111 ENOG41088T4 Helicase IV N646_4112 ENOG4108Z5K methylglyoxal synthase N646_4113 ENOG4108SV3 Tmao reductase system periplasmic protein tort N646_4114 ENOG4105BZU Histidine kinase N646_4118 ENOG4105E3W Two component transcriptional regulator (Winged helix family N646_4119 ENOG4105ENH Sulfatase N646_4121 ENOG41061MV Arylsulfatase N646_4122 ENOG4105C4X radical SAM domain protein N646_4123 ENOG4105C7R Atpase associated with various cellular activities aaa_3 N646_4129 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) N646_4130 ENOG41064T2 transcriptional regulator, lysR family N646_4131 ENOG4107TE5 Lipid kinase N646_4132 ENOG4108YDI single-species biofilm formation on inanimate substrate N646_4134 ENOG4105F2V VRR-NUC domain-containing protein N646_4137 ENOG4105CEE C4-dicarboxylate transporter N646_4141 ENOG4108MGY Histidine kinase N646_4142 ENOG4107KBT 8-Amino-7-oxononanoate synthase N646_4143 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) N646_4144 ENOG4105BZU Histidine kinase N646_4145 ENOG4105BZU Histidine kinase N646_4146 ENOG4105WH1 Two component transcriptional regulator luxr family N646_4147 ENOG4105BZU Histidine kinase N646_4149 ENOG4108WQH regulatoR N646_4150 ENOG4107R88 Chemotaxis protein (CheV) N646_4151 ENOG4108VAU general secretion pathway protein G N646_4153 ENOG4105FR1 rard protein N646_4158 ENOG4108I0N Transporter, RarD family, DMT superfamily protein N646_4161 ENOG4107RGH Aldehyde dehydrogenase N646_4163 ENOG4105CBC glutamate synthase N646_4164 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) N646_4169 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase N646_4170 ENOG4108UYE Lactoylglutathione lyase N646_4174 ENOG4105CJW magnesium transporter N646_4180 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) N646_4188 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) N646_4195 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) N646_4196 ENOG4108IPJ Membrane N646_4197 ENOG4105EJC lysr family transcriptional regulator N646_4198 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) N646_4199 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase N646_4200 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor N646_4201 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) N646_4202 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) N646_4204 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) N646_4210 ENOG4105DM4 PTS System N646_4211 ENOG4105DE4 1-phosphofructokinase N646_4212 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein N646_4214 ENOG4107B7Y DNA-binding transcriptional regulator FruR N646_4217 ENOG4108NJZ Sensory box GGDEF EAL domain protein N646_4218 ENOG4105DRP amino acid AbC transporter N646_4219 ENOG4106TNF Periplasmic binding protein N646_4220 ENOG4105E5Q amino acid AbC transporter N646_4221 ENOG4105CDA abc transporter atp-binding protein N646_4223 ENOG4108I6A alcohol dehydrogenase N646_4224 ENOG4105CF7 AraC family transcriptional regulator N646_4226 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) N646_4227 ENOG4105CKU formyltetrahydrofolate synthetase N646_4228 ENOG4107RE1 Inosine-guanosine kinase N646_4231 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) N646_4232 ENOG4108N3W hemolysin secretion protein N646_4234 ENOG4108ZYK Acyl carrier protein phosphodiesterase N646_4236 ENOG4105C1J atp-dependent rna helicase N646_4241 ENOG4105DS1 cytochrome b561 N646_4242 ENOG4108YYC ycei family N646_4243 ENOG4105TMB Formate nitrite transporter N646_4244 ENOG4105DUM transcriptional regulator, lysR family N646_4245 ENOG4108UQ5 membrane protein YcdZ N646_4246 ENOG4105CPB ATP-dependent endonuclease of the OLD family N646_4247 ENOG4105CGH 5'-nucleotidase N646_4248 ENOG4105DU1 integral membrane protein, terc N646_4252 ENOG4108M0H Extracellular lipase N646_4253 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation N646_4256 ENOG4105KA0 thioesterase Superfamily protein N646_4258 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) N646_4266 ENOG4105BZU Histidine kinase N646_4267 ENOG4105RKW reductase (By N646_4269 ENOG4108I0Y (ABC) transporter N646_4270 ENOG4105CV6 ABC transporter, permease N646_4272 ENOG4107R7A Allophanate hydrolase subunit 2 N646_4273 ENOG4105P4J Allophanate hydrolase, subunit 1 N646_4274 ENOG4105E7W lamb ycsf family protein N646_4275 ENOG4105BZU Histidine kinase N646_4276 ENOG4105CMR udp-glucose 4-epimerase N646_4280 ENOG4105CWB LysR family transcriptional Regulator N646_4281 ENOG4105CD5 CoA-binding domain protein N646_4283 ENOG4105CPF Cell wall formation (By similarity) N646_4285 ENOG4108ZJT translation initiation factor, Sui1 N646_4295 ENOG4105MQ5 zona occludens toxin N646_4299 ENOG4105EJC lysr family transcriptional regulator N646_4307 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) N646_4308 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) N646_4311 ENOG4105BZU Histidine kinase N646_4314 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) N646_4315 ENOG4105E0C molybdate abc transporter N646_4316 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein N646_4317 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) N646_4318 ENOG4105WXI Bacterial OB fold (BOF) protein N646_4321 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) N646_4322 ENOG4105CGF Aromatic amino acid aminotransferase N646_4324 ENOG4108K01 transcriptional regulator N646_4325 ENOG4105UQX Mate efflux family protein N646_4326 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) N646_4327 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase N646_4335 ENOG4107TIF Phenazine biosynthesis protein, PhzF family N646_4338 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit N646_4339 ENOG4105C5Q Transcriptional regulator N646_4340 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) N646_4341 ENOG4105CXY transporter N646_4342 ENOG4108KX4 response regulator N646_4343 ENOG4105BZU Histidine kinase N646_4344 ENOG4105BZU Histidine kinase N646_4345 ENOG4105CXY transporter N646_4346 ENOG4105EIP mannose-6-phosphate isomerase N646_4350 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) N646_4351 ENOG4105K63 Thioredoxin N646_4352 ENOG4108ISG Major Facilitator N646_4353 ENOG4105VXR cytoplasmic protein N646_4354 ENOG4105KNA -acetyltransferase N646_4359 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter N646_4362 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) N646_4363 ENOG4105TMB Formate nitrite transporter N646_4364 ENOG4105WZK nitrite reductase NADPH small subunit N646_4365 ENOG4107QZF nitrite reductase NADPH large subunit N646_4366 ENOG4105NXH GreA GreB family elongation factor N646_4367 ENOG4105BZU Histidine kinase N646_4369 ENOG4105BZU Histidine kinase N646_4370 ENOG4105DEN Luciferase family N646_4375 ENOG4108NVR Methyl-accepting chemotaxis N646_4376 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) N646_4379 ENOG4105CXG d-lactate dehydrogenase N646_4380 ENOG4105CC0 LysR family Transcriptional regulator N646_4382 ENOG4105EV2 VWA domain protein interacting with AAA ATPase N646_4383 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) N646_4385 ENOG4105C5W Aldolase N646_4387 ENOG4105CSX c4-dicarboxylate anaerobic carrier N646_4389 ENOG4105QNF Outer membrane lipoprotein N646_4392 ENOG4105EYH Exonuclease N646_4393 ENOG4107RFY SbcCD D subunit N646_4399 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit N646_4408 ENOG4108ZF3 Phosphatase N646_4411 ENOG4106VK6 Flagellar motor protein N646_4415 ENOG4105D9P serine threonine protein kinase N646_4419 ENOG4105F8J Adenylate Guanylate cyclase N646_4426 ENOG4107QZF nitrite reductase NADPH large subunit N646_4427 ENOG4105D7T ABC transporter N646_4428 ENOG4105DG7 nitrate ABC transporter N646_4437 ENOG4105C44 Serine transporter N646_4438 ENOG4105BZU Histidine kinase N646_4444 ENOG4105ETX regulatoR N646_4451 ENOG4106E5D Protein of unknown function (DUF461) N646_4452 ENOG4105CHR reductase N646_4453 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) N646_4456 ENOG4108UHU Aldolase N646_4457 ENOG4107SS6 2-dehydro-3-deoxygluconokinase N646_4458 ENOG4105M5J Cupin 2, conserved barrel domain protein N646_4459 ENOG4105EY3 heparinase II III family protein N646_4460 ENOG4105EY3 heparinase II III family protein N646_4467 ENOG4107EJG GntR family transcriptional regulator N646_4468 ENOG4107EJG GntR family transcriptional regulator N646_4469 ENOG41080XP Cbs domain N646_4470 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) N646_4471 ENOG4107RJ1 sodium solute N646_4475 ENOG4107RUY (E1 component), alpha subunit N646_4477 ENOG4107QSN dihydrolipoamide acetyltransferase N646_4478 ENOG4105C10 Electron transfer flavoprotein N646_4479 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase N646_4480 ENOG4105EXG Transcriptional regulator N646_4483 ENOG4105DUM transcriptional regulator, lysR family N646_4485 ENOG4105DMR ABC, transporter N646_4486 ENOG4105GBT ABC transporter N646_4487 ENOG4106PMH Extracellular solute-binding protein family 3 N646_4488 ENOG4105E5Z arginine transporter ATP-binding subunit N646_4496 ENOG4105C26 Dehydrogenase N646_4499 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase N646_4500 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) N646_4502 ENOG4105CCU oxidase (Subunit III) N646_4503 ENOG4105BZ9 Cytochrome C oxidase, subunit I N646_4504 ENOG4105E2S oxidase) subunit II N646_4505 ENOG4105CHR reductase N646_4506 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase N646_4507 ENOG4105E39 Enoyl-CoA hydratase N646_4508 ENOG4105E39 Enoyl-CoA hydratase N646_4510 ENOG4105C26 Dehydrogenase N646_4511 ENOG4105CHU acetyl-coa acetyltransferase N646_4513 ENOG4105C1G acyl-Coa dehydrogenase N646_4514 ENOG4107QX3 carboxylase N646_4515 ENOG4105E39 Enoyl-CoA hydratase N646_4516 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase N646_4518 ENOG4105CQB FAD linked oxidase domain protein N646_4520 ENOG4107U2T alpha beta N646_4521 ENOG4105ECQ AraC Family Transcriptional Regulator N646_4524 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system N646_4525 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component N646_4526 ENOG4108IJ8 ABC transporter N646_4527 ENOG4105E90 ABC transporter N646_4528 ENOG4107SDU Methyl-accepting chemotaxis N646_4531 ENOG41076UM multiple antibiotic resistance (MarC)-related protein N646_4532 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters N646_4534 ENOG4105CKI cobalamin synthesis protein N646_4535 ENOG4105DR5 peptidase N646_4537 ENOG4105CKI cobalamin synthesis protein N646_4540 ENOG4105MYN Zinc uptake regulation protein N646_4543 ENOG4105HF0 Membrane N646_4547 ENOG4105ENX hydrolase N646_4548 ENOG4105ENX hydrolase N646_4549 ENOG4105EQ2 LysR family Transcriptional regulator N646_4550 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) N646_4553 ENOG4105C1J atp-dependent rna helicase N646_4554 ENOG4108ENQ Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) N646_4557 ENOG4105CVA phosphate N646_4560 ENOG4105DKW ABC transporter N646_4561 ENOG4105CXC rtn protein N646_4566 ENOG4105C1J atp-dependent rna helicase N646_4567 ENOG4105CKI cobalamin synthesis protein N646_4569 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) N646_4571 ENOG4105VEQ Cold shock protein N646_4573 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) N646_4575 ENOG4105VYA Uncharacterized conserved protein (DUF2132) N646_4576 ENOG4105C1J atp-dependent rna helicase N646_4579 ENOG4105VRT cytoplasmic protein N646_4583 ENOG41090A4 Pterin carbinolamine dehydratase N646_4584 ENOG4105MIR Phenylalanine 4-monooxygenase N646_4585 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) N646_4586 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) N646_4591 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain N646_4592 ENOG4105C0A alcohol dehydrogenase N646_4595 ENOG4108RS6 transposase N646_4596 ENOG4108RMU ferritin dps family protein N646_4597 ENOG4105C8Q Methyl-accepting chemotaxis N646_4605 ENOG4108MGY Histidine kinase N646_4606 ENOG4105DFG type I secretion outer membrane protein N646_4610 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) N646_4612 ENOG4105BZU Histidine kinase N646_4614 ENOG4105VEQ Cold shock protein N646_4618 ENOG4105CDV Ompa motb domain protein N646_4620 ENOG4108V1T peptidylprolyl cis-trans isomerase N646_4621 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) N646_4622 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) N646_4627 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) N646_4636 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase N646_4639 ENOG4108SXK Transporter Drug Metabolite Exporter family N646_4640 ENOG4105VW4 glutaredoxin 3 N646_4643 ENOG4105E5M Multidrug resistance protein D N646_4644 ENOG4105CR8 Transcriptional regulator N646_4646 ENOG4105DR5 peptidase N646_4650 ENOG4105DWD nucleoside recognition domain protein N646_4651 ENOG4105C8Q Methyl-accepting chemotaxis N646_4653 ENOG4105E0U tyrosine-specific transport protein N646_4658 ENOG4107RGM aldo keto reductase N646_4660 ENOG4105JQN Transcriptional regulator N646_4664 ENOG4105KVH Transcriptional regulator N646_4665 ENOG4108RS6 transposase N646_4668 ENOG4105D6J arsenicaL-resistance protein N646_4670 ENOG4108V1U phospholipid-binding protein N646_4671 ENOG4105JAB phenazine biosynthesis protein, phzf family N646_4673 ENOG4105CJ1 ABC, transporter N646_4674 ENOG4107QWP ABC-2 type transporter N646_4676 ENOG4108IEG Formate dehydrogenase Alpha subunit N646_4680 ENOG4108IJF Heavy metal efflux pump, CzcA N646_4685 ENOG4108HK0 -acetyltransferase N646_4687 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation N646_4689 ENOG4105ENT Efflux transporter rnd family, mfp subunit N646_4692 ENOG4105C5H ABC transporter N646_4693 ENOG4108M6U Universal stress protein A N646_4694 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein N646_4695 ENOG4105CKD glutathione-regulated potassium-efflux system protein N646_4699 ENOG4105VUF Transcriptional regulator N646_4700 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase N646_4702 ENOG4105KXC Collagenase N646_4705 ENOG4105CR8 Transcriptional regulator N646_4706 ENOG4105C8Q Methyl-accepting chemotaxis N646_4708 ENOG41061MD high-affinity nickel-transporter N646_4709 ENOG41090EM Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter N646_4710 ENOG4105C6Z Gluconate N646_4711 ENOG4105EXW epimerase dehydratase N646_4712 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) N646_4713 ENOG4105FB2 class II Aldolase N646_4714 ENOG4105G63 Type III effector Hrp-dependent N646_4715 ENOG4105ZXK Dehydrogenase N646_4716 ENOG4105MVE transcriptional regulator N646_4718 ENOG4105DEF Extracellular solute-binding protein, family 5 N646_4719 ENOG4108JQ7 (ABC) transporter N646_4720 ENOG4105C3U ABC transporter N646_4721 ENOG4107R73 Mate efflux family protein N646_4722 ENOG4105KQ5 peptidylprolyl cis-trans isomerase