locus-tag	class	description
N646_0001	COG1169	isochorismate synthase
N646_0005	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
N646_0006	COG1441	menaquinone biosynthetic process
N646_0009	COG2855	membrane
N646_0010	COG0477	Major facilitator Superfamily
N646_0014	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N646_0015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N646_0018	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N646_0019	COG1522	sequence-specific DNA binding
N646_0021	COG1946	Acyl-CoA thioesterase
N646_0022	COG3126	Type III secretion system lipoprotein chaperone (YscW)
N646_0025	COG3706	GGDEF domain
N646_0026	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N646_0027	COG0517	IMP dehydrogenase activity
N646_0027	COG0516	GMP reductase activity
N646_0032	COG0537	adenosine 5'-monophosphoramidase activity
N646_0037	COG3150	esterase
N646_0038	COG1252	NADH dehydrogenase
N646_0041	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N646_0043	COG4591	ABC-type transport system involved in lipoprotein release permease component
N646_0044	COG1136	(ABC) transporter
N646_0045	COG4591	ABC-type transport system involved in lipoprotein release permease component
N646_0047	COG2333	competence protein COMEC
N646_0047	COG0658	competence protein
N646_0048	COG1132	(ABC) transporter
N646_0052	COG2719	SpoVR family
N646_0053	COG2718	Belongs to the UPF0229 family
N646_0054	COG2766	serine protein kinase
N646_0055	COG3013	Belongs to the UPF0304 family
N646_0057	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
N646_0059	COG1882	Formate acetyltransferase
N646_0065	COG4215	(ABC) transporter
N646_0068	COG0708	Exodeoxyribonuclease III
N646_0070	COG3923	Primosomal replication protein n
N646_0071	COG0730	response to heat
N646_0072	COG1199	ATP-dependent helicase activity
N646_0073	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
N646_0074	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
N646_0075	COG1187	pseudouridine synthase activity
N646_0077	COG1278	Cold shock
N646_0078	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
N646_0079	COG0542	response to heat
N646_0080	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N646_0081	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
N646_0082	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
N646_0087	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N646_0088	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
N646_0089	COG0297	glycogen (starch) synthase activity
N646_0093	COG3070	regulator of competence-specific genes
N646_0094	COG1609	Transcriptional regulator
N646_0095	COG3381	protein complex oligomerization
N646_0096	COG0745	RESPONSE REGULATOR receiver
N646_0097	COG1434	Gram-negative-bacterium-type cell wall biogenesis
N646_0098	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N646_0100	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
N646_0101	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
N646_0105	COG4067	protein conserved in archaea
N646_0105	COG0189	ligase activity
N646_0106	COG0500	methyltransferase
N646_0108	COG1801	Protein of unknown function DUF72
N646_0110	COG0217	transcriptional regulatory protein
N646_0111	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
N646_0112	COG0632	four-way junction helicase activity
N646_0113	COG2255	four-way junction helicase activity
N646_0114	COG1271	oxidase subunit
N646_0115	COG1294	oxidase, subunit
N646_0117	COG0824	Thioesterase
N646_0118	COG0811	peptide transport
N646_0121	COG0823	Involved in the tonB-independent uptake of proteins
N646_0122	COG2885	chlorophyll binding
N646_0123	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
N646_0124	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
N646_0126	COG3766	membrane
N646_0128	COG0754	glutathionylspermidine amidase activity
N646_0130	COG5002	protein histidine kinase activity
N646_0130	COG0784	Response regulator, receiver
N646_0136	COG1294	oxidase, subunit
N646_0137	COG1271	oxidase subunit
N646_0140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N646_0141	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N646_0147	COG3568	Endonuclease Exonuclease Phosphatase
N646_0154	COG0583	DNA-binding transcription factor activity
N646_0156	COG0686	Belongs to the AlaDH PNT family
N646_0158	COG1674	ftsk spoiiie
N646_0160	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N646_0162	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
N646_0167	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
N646_0171	COG0300	oxidoreductase activity
N646_0174	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
N646_0176	COG2268	Band 7 protein
N646_0178	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N646_0179	COG2915	High frequency lysogenization protein hflD homolog
N646_0182	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N646_0184	COG1757	Na H antiporter
N646_0187	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N646_0189	COG0131	Imidazoleglycerol-phosphate dehydratase
N646_0189	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
N646_0190	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
N646_0191	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
N646_0192	COG0107	imidazoleglycerol-phosphate synthase activity
N646_0193	COG0140	phosphoribosyl-ATP diphosphatase activity
N646_0193	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
N646_0194	COG3012	SEC-C Motif Domain Protein
N646_0195	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
N646_0196	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N646_0197	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
N646_0198	COG0215	cysteine-tRNA ligase activity
N646_0199	COG1435	thymidine kinase activity
N646_0205	COG2116	formate transmembrane transporter activity
N646_0207	COG0390	transport system, permease component
N646_0208	COG4459	periplasmic nitrate reductase
N646_0209	COG3005	denitrification pathway
N646_0210	COG0243	molybdopterin cofactor binding
N646_0213	COG1227	inorganic diphosphatase activity
N646_0215	COG4172	Belongs to the ABC transporter superfamily
N646_0217	COG4171	peptide transport system, permease
N646_0218	COG4168	peptide transport system, permease
N646_0220	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
N646_0221	COG1842	Phage shock protein A
N646_0223	COG1983	PspC domain protein
N646_0227	COG2818	Glycosylase
N646_0228	COG5380	lipid catabolic process
N646_0229	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
N646_0230	COG0626	cystathionine gamma-synthase activity
N646_0232	COG0733	neurotransmitter:sodium symporter activity
N646_0233	COG0564	pseudouridine synthase activity
N646_0234	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
N646_0234	COG0116	Belongs to the methyltransferase superfamily
N646_0235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N646_0236	COG1151	hydroxylamine reductase activity
N646_0237	COG3604	Transcriptional regulator
N646_0239	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N646_0240	COG4136	ATPase activity
N646_0241	COG4135	transport system, permease component
N646_0242	COG4134	Bacterial extracellular solute-binding protein
N646_0249	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
N646_0250	COG2205	protein histidine kinase activity
N646_0251	COG0745	RESPONSE REGULATOR receiver
N646_0253	COG1061	Type III restriction enzyme res subunit
N646_0254	COG1187	pseudouridine synthase activity
N646_0256	COG2814	Major facilitator Superfamily
N646_0258	COG0702	epimerase
N646_0259	COG0534	Mate efflux family protein
N646_0263	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N646_0266	COG1960	acyl-CoA dehydrogenase activity
N646_0267	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
N646_0268	COG2985	domain, Protein
N646_0268	COG3273	potassium ion transport
N646_0269	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N646_0271	COG1737	Transcriptional regulator
N646_0272	COG0076	glutamate decarboxylase activity
N646_0275	COG2431	L-lysine efflux transmembrane transporter activity
N646_0278	COG3070	regulator of competence-specific genes
N646_0282	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N646_0282	COG4191	Histidine kinase
N646_0284	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
N646_0286	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
N646_0287	COG4988	ABC transporter
N646_0288	COG0492	ferredoxin-NADP+ reductase activity
N646_0292	COG0745	RESPONSE REGULATOR receiver
N646_0292	COG3706	GGDEF domain
N646_0294	COG0471	metal ion transport
N646_0295	COG2949	membrane
N646_0296	COG0281	malic enzyme
N646_0297	COG1643	Atp-dependent helicase
N646_0300	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
N646_0307	COG0277	FAD linked oxidase domain protein
N646_0307	COG0247	lactate metabolic process
N646_0310	COG2986	histidine ammonia-lyase
N646_0311	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
N646_0312	COG0010	Belongs to the arginase family
N646_0313	COG1228	amidohydrolase
N646_0317	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
N646_0319	COG0291	Belongs to the bacterial ribosomal protein bL35 family
N646_0321	COG0393	Putative heavy-metal-binding
N646_0328	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
N646_0329	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N646_0329	COG0072	phenylalanine-tRNA ligase activity
N646_0331	COG0776	regulation of translation
N646_0333	COG0500	methyltransferase
N646_0334	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
N646_0335	COG0295	cytidine deaminase activity
N646_0336	COG1346	cytolysis
N646_0337	COG1380	Effector of murein hydrolase LrgA
N646_0338	COG2925	Exonuclease
N646_0341	COG0702	epimerase
N646_0342	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
N646_0343	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
N646_0344	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
N646_0348	COG2988	succinylglutamate desuccinylase activity
N646_0349	COG4139	cobalamin transport
N646_0350	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
N646_0354	COG0583	DNA-binding transcription factor activity
N646_0356	COG1451	nucleotide metabolic process
N646_0357	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
N646_0364	COG3938	Belongs to the proline racemase family
N646_0368	COG2423	ornithine cyclodeaminase activity
N646_0369	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N646_0370	COG3842	ATPase activity
N646_0371	COG1176	ABC-type spermidine putrescine transport system, permease component I
N646_0372	COG1177	transmembrane transport
N646_0375	COG3291	Pkd domain containing protein
N646_0378	COG0444	Belongs to the ABC transporter superfamily
N646_0379	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N646_0380	COG0601	transmembrane transport
N646_0382	COG2195	Cleaves the N-terminal amino acid of tripeptides
N646_0384	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
N646_0386	COG0625	glutathione transferase activity
N646_0394	COG3755	Protein conserved in bacteria
N646_0401	COG1757	Na H antiporter
N646_0402	COG0174	glutamine synthetase
N646_0403	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
N646_0404	COG1396	sequence-specific DNA binding
N646_0404	COG1917	Cupin 2, conserved barrel domain protein
N646_0405	COG1012	belongs to the aldehyde dehydrogenase family
N646_0406	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N646_0408	COG2957	Belongs to the agmatine deiminase family
N646_0409	COG1012	belongs to the aldehyde dehydrogenase family
N646_0410	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N646_0411	COG2200	EAL domain
N646_0413	COG1846	Transcriptional regulator
N646_0414	COG2315	Protein conserved in bacteria
N646_0422	COG3063	Type IV pilus biogenesis stability protein PilW
N646_0423	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
N646_0426	COG1560	Kdo2-lipid A biosynthetic process
N646_0427	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
N646_0428	COG1280	lysine exporter protein (LysE YggA)
N646_0430	COG1115	amino acid carrier protein
N646_0435	COG1368	sulfuric ester hydrolase activity
N646_0436	COG2113	Glycine betaine
N646_0437	COG4176	ABC-type proline glycine betaine transport system permease component
N646_0438	COG4175	Glycine betaine
N646_0441	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N646_0442	COG0456	acetyltransferase
N646_0443	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N646_0444	COG0662	Cupin 2, conserved barrel domain protein
N646_0445	COG0527	aspartate kinase activity
N646_0446	COG1943	Transposase
N646_0447	COG3119	arylsulfatase activity
N646_0450	COG0641	radical SAM
N646_0453	COG3119	arylsulfatase activity
N646_0461	COG1538	Outer membrane efflux protein
N646_0464	COG1349	DNA-binding transcription factor activity
N646_0465	COG0673	inositol 2-dehydrogenase activity
N646_0466	COG4702	Belongs to the UPF0303 family
N646_0467	COG0745	RESPONSE REGULATOR receiver
N646_0467	COG3706	GGDEF domain
N646_0470	COG0471	metal ion transport
N646_0473	COG5001	Diguanylate cyclase
N646_0473	COG3300	MHYT domain
N646_0476	COG1328	CTP reductase activity
N646_0477	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
N646_0479	COG0861	Integral membrane protein TerC family
N646_0481	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
N646_0483	COG0814	amino acid
N646_0486	COG1120	ATPase activity
N646_0487	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
N646_0489	COG4774	siderophore transport
N646_0491	COG1132	(ABC) transporter
N646_0492	COG1132	(ABC) transporter
N646_0495	COG0583	DNA-binding transcription factor activity
N646_0500	COG0443	Heat shock 70 kDa protein
N646_0501	COG0443	Heat shock 70 kDa protein
N646_0512	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
N646_0513	COG1643	Atp-dependent helicase
N646_0516	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N646_0518	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N646_0519	COG1215	transferase activity, transferring glycosyl groups
N646_0520	COG0438	transferase activity, transferring glycosyl groups
N646_0526	COG0438	transferase activity, transferring glycosyl groups
N646_0527	COG0297	glycogen (starch) synthase activity
N646_0528	COG2204	response regulator
N646_0534	COG1793	dna ligase
N646_0536	COG0534	Mate efflux family protein
N646_0537	COG0307	riboflavin synthase, alpha
N646_0541	COG3706	GGDEF domain
N646_0543	COG0791	NLP P60 protein
N646_0551	COG1940	carbohydrate kinase activity
N646_0553	COG0303	'Molybdopterin
N646_0554	COG0746	molybdenum cofactor guanylyltransferase activity
N646_0555	COG3842	ATPase activity
N646_0558	COG2204	response regulator
N646_0559	COG3852	Histidine kinase
N646_0560	COG0488	(ABC) transporter
N646_0561	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
N646_0565	COG3381	protein complex oligomerization
N646_0567	COG0243	molybdopterin cofactor binding
N646_0567	COG3383	formate dehydrogenase (NAD+) activity
N646_0568	COG0437	4 iron, 4 sulfur cluster binding
N646_0573	COG0004	ammonium transporteR
N646_0574	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
N646_0575	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
N646_0576	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
N646_0577	COG1177	transmembrane transport
N646_0578	COG1176	ABC-type spermidine putrescine transport system, permease component I
N646_0579	COG3842	ATPase activity
N646_0584	COG1943	Transposase
N646_0585	COG0589	response to stress
N646_0586	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N646_0589	COG2217	Heavy metal translocating P-type atpase
N646_0591	COG2010	Cytochrome c
N646_0594	COG3278	Belongs to the heme-copper respiratory oxidase family
N646_0597	COG2205	protein histidine kinase activity
N646_0597	COG0784	Response regulator, receiver
N646_0607	COG4128	Pfam Zonular occludens toxin
N646_0616	COG3120	sequence-specific DNA binding
N646_0618	COG1067	ATP-dependent peptidase activity
N646_0619	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N646_0624	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
N646_0624	COG0116	Belongs to the methyltransferase superfamily
N646_0627	COG0167	dihydroorotate dehydrogenase activity
N646_0629	COG2902	Dehydrogenase
N646_0630	COG0308	aminopeptidase N
N646_0633	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
N646_0634	COG1956	GAF domain-containing protein
N646_0635	COG1132	(ABC) transporter
N646_0636	COG2995	paraquat-inducible protein a
N646_0637	COG3008	intermembrane lipid transfer
N646_0642	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N646_0643	COG1666	GTP binding
N646_0645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N646_0647	COG4597	amino acid ABC transporter
N646_0648	COG0765	amino acid transport
N646_0649	COG1126	abc transporter atp-binding protein
N646_0650	COG0670	Belongs to the BI1 family
N646_0652	COG2920	part of a sulfur-relay system
N646_0653	COG1254	Belongs to the acylphosphatase family
N646_0654	COG0840	transmembrane signaling receptor activity
N646_0667	COG2885	chlorophyll binding
N646_0672	COG2203	Gaf domain
N646_0672	COG2199	diguanylate cyclase activity
N646_0674	COG1414	Transcriptional regulator
N646_0676	COG0656	L-ascorbic acid biosynthetic process
N646_0677	COG0583	DNA-binding transcription factor activity
N646_0679	COG0583	DNA-binding transcription factor activity
N646_0680	COG2814	Major facilitator Superfamily
N646_0684	COG1335	isochorismatase
N646_0685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N646_0688	COG1410	methionine synthase
N646_0688	COG0646	methionine synthase
N646_0690	COG1126	abc transporter atp-binding protein
N646_0691	COG0765	amino acid transport
N646_0692	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N646_0695	COG0583	DNA-binding transcription factor activity
N646_0698	COG0583	DNA-binding transcription factor activity
N646_0700	COG0583	DNA-binding transcription factor activity
N646_0703	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
N646_0704	COG0602	queuosine metabolic process
N646_0705	COG0561	phosphatase activity
N646_0710	COG2828	Protein conserved in bacteria
N646_0712	COG0372	Belongs to the citrate synthase family
N646_0713	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
N646_0720	COG0730	response to heat
N646_0723	COG1943	Transposase
N646_0726	COG0457	Tetratricopeptide repeat
N646_0739	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N646_0740	COG4790	Type iii secretion
N646_0741	COG4794	Type iii secretion
N646_0742	COG4791	protein targeting
N646_0743	COG4792	protein secretion
N646_0744	COG2207	Transcriptional regulator
N646_0751	COG3177	Filamentation induced by cAMP protein fic
N646_0755	COG4669	(LipO)protein
N646_0769	COG1012	belongs to the aldehyde dehydrogenase family
N646_0770	COG3284	Transcriptional regulator
N646_0773	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
N646_0774	COG0363	glucosamine-6-phosphate deaminase activity
N646_0775	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
N646_0776	COG2207	Transcriptional regulator
N646_0778	COG4565	transcriptional regulatory protein
N646_0779	COG3290	protein histidine kinase activity
N646_0781	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N646_0787	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
N646_0789	COG2985	domain, Protein
N646_0795	COG2272	Belongs to the type-B carboxylesterase lipase family
N646_0796	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N646_0797	COG0729	surface antigen
N646_0799	COG1280	lysine exporter protein (LysE YggA)
N646_0800	COG1280	lysine exporter protein (LysE YggA)
N646_0801	COG5507	3-demethylubiquinone-9 3-methyltransferase
N646_0804	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N646_0805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N646_0806	COG0110	maltose O-acetyltransferase activity
N646_0820	COG2211	Major facilitator Superfamily
N646_0821	COG2977	Belongs to the P-Pant transferase superfamily
N646_0823	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N646_0824	COG1028	Short-chain dehydrogenase reductase Sdr
N646_0825	COG1169	isochorismate synthase
N646_0826	COG1021	2,3-dihydroxybenzoate-AMP ligase
N646_0827	COG3433	isochorismatase activity
N646_0827	COG1535	isochorismatase
N646_0828	COG4592	Periplasmic binding protein
N646_0831	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N646_0832	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N646_0833	COG1120	ATPase activity
N646_0836	COG2382	esterase
N646_0837	COG1629	transport
N646_0837	COG4774	siderophore transport
N646_0841	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N646_0856	COG0456	acetyltransferase
N646_0859	COG0456	acetyltransferase
N646_0893	COG2026	Addiction module toxin, RelE StbE family
N646_0894	COG2801	Transposase and inactivated derivatives
N646_0898	COG2801	Transposase and inactivated derivatives
N646_0900	COG1357	PFAM Pentapeptide repeats (8 copies)
N646_0901	COG2801	Transposase and inactivated derivatives
N646_0930	COG0625	glutathione transferase activity
N646_0933	COG2026	Addiction module toxin, RelE StbE family
N646_0937	COG1335	isochorismatase
N646_0947	COG2026	Addiction module toxin, RelE StbE family
N646_0948	COG2801	Transposase and inactivated derivatives
N646_0956	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N646_0958	COG3768	UPF0283 membrane protein
N646_0959	COG3106	COG3106 Predicted ATPase
N646_0962	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N646_0963	COG0784	Response regulator, receiver
N646_0963	COG2205	protein histidine kinase activity
N646_0965	COG0494	nUDIX hydrolase
N646_0966	COG0814	amino acid
N646_0967	COG1760	l-serine dehydratase
N646_0968	COG2200	EAL domain
N646_0970	COG0720	synthase
N646_0972	COG2205	protein histidine kinase activity
N646_0972	COG0784	Response regulator, receiver
N646_0972	COG5002	protein histidine kinase activity
N646_0973	COG5001	Diguanylate cyclase
N646_0973	COG3300	MHYT domain
N646_0974	COG0840	transmembrane signaling receptor activity
N646_0975	COG0017	Asparaginyl-tRNA synthetase
N646_0977	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N646_0981	COG1448	Aminotransferase
N646_0985	COG0840	transmembrane signaling receptor activity
N646_0986	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N646_0992	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
N646_0995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N646_0996	COG3108	Peptidase M15
N646_0997	COG2989	Protein conserved in bacteria
N646_1002	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N646_1004	COG3088	subunit of a heme lyase
N646_1004	COG4235	cytochrome complex assembly
N646_1006	COG1138	Cytochrome C-type biogenesis protein
N646_1007	COG3301	Polysulphide reductase, NrfD
N646_1008	COG0437	4 iron, 4 sulfur cluster binding
N646_1010	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
N646_1014	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N646_1016	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N646_1017	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N646_1022	COG0019	diaminopimelate decarboxylase activity
N646_1027	COG0322	excinuclease ABC activity
N646_1028	COG2197	response regulator
N646_1029	COG0417	DNA replication proofreading
N646_1033	COG1187	pseudouridine synthase activity
N646_1035	COG0009	L-threonylcarbamoyladenylate synthase
N646_1036	COG0613	PHP domain protein
N646_1038	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N646_1039	COG0512	Glutamine amidotransferase of anthranilate synthase
N646_1041	COG0134	indole-3-glycerol-phosphate synthase activity
N646_1041	COG0135	phosphoribosylanthranilate isomerase activity
N646_1043	COG0159	tryptophan synthase activity
N646_1044	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N646_1045	COG0318	PFAM AMP-dependent synthetase and ligase
N646_1047	COG1301	dicarboxylic acid transport
N646_1051	COG2917	probably involved in intracellular septation
N646_1052	COG1607	acyl-coa hydrolase
N646_1053	COG2350	Protein conserved in bacteria
N646_1055	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
N646_1056	COG0583	DNA-binding transcription factor activity
N646_1059	COG5001	Diguanylate cyclase
N646_1060	COG1032	radical SAM domain protein
N646_1064	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
N646_1065	COG0463	Glycosyl transferase, family 2
N646_1066	COG0745	RESPONSE REGULATOR receiver
N646_1067	COG3850	Histidine kinase
N646_1067	COG5002	protein histidine kinase activity
N646_1073	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
N646_1077	COG1136	(ABC) transporter
N646_1077	COG0577	efflux transmembrane transporter activity
N646_1078	COG1136	(ABC) transporter
N646_1078	COG0577	efflux transmembrane transporter activity
N646_1079	COG0577	efflux transmembrane transporter activity
N646_1079	COG1136	(ABC) transporter
N646_1081	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N646_1085	COG3118	belongs to the thioredoxin family
N646_1086	COG4232	protein-disulfide reductase activity
N646_1093	COG2863	cytochrome
N646_1094	COG3258	Cytochrome c
N646_1095	COG2995	paraquat-inducible protein a
N646_1096	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
N646_1096	COG3008	intermembrane lipid transfer
N646_1100	COG4166	transmembrane transport
N646_1102	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
N646_1103	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
N646_1105	COG0539	negative regulation of cytoplasmic translation
N646_1106	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
N646_1108	COG0616	signal peptide processing
N646_1109	COG1028	Short-chain dehydrogenase reductase Sdr
N646_1112	COG0587	DNA-directed DNA polymerase activity
N646_1113	COG0784	Response regulator, receiver
N646_1113	COG0835	chemotaxis
N646_1115	COG1940	carbohydrate kinase activity
N646_1116	COG0469	pyruvate kinase activity
N646_1117	COG4667	esterase of the alpha-beta hydrolase superfamily
N646_1120	COG0733	neurotransmitter:sodium symporter activity
N646_1122	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N646_1122	COG1263	PTS System
N646_1123	COG0084	hydrolase, TatD family'
N646_1124	COG0470	DNA polymerase III
N646_1125	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
N646_1126	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
N646_1132	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N646_1133	COG0416	fatty acid biosynthetic process
N646_1135	COG1399	metal-binding, possibly nucleic acid-binding protein
N646_1136	COG0424	maF-like protein
N646_1137	COG0564	pseudouridine synthase activity
N646_1138	COG1530	ribonuclease E activity
N646_1139	COG0659	secondary active sulfate transmembrane transporter activity
N646_1140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N646_1141	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
N646_1143	COG0572	uridine kinase
N646_1147	COG2186	Transcriptional regulator
N646_1148	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N646_1149	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
N646_1150	COG0653	protein targeting
N646_1151	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N646_1152	COG3706	GGDEF domain
N646_1153	COG0366	Alpha amylase catalytic
N646_1154	COG1122	ATPase activity
N646_1155	COG4120	Belongs to the binding-protein-dependent transport system permease family
N646_1157	COG3092	negative regulation of chromosome organization
N646_1158	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N646_1159	COG0857	belongs to the CobB CobQ family
N646_1159	COG0280	phosphate acetyltransferase
N646_1161	COG0435	Glutathione S-transferase
N646_1163	COG0444	Belongs to the ABC transporter superfamily
N646_1164	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N646_1165	COG0601	transmembrane transport
N646_1167	COG0314	molybdopterin synthase activity
N646_1168	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
N646_1169	COG0315	cyclic pyranopterin monophosphate synthase activity
N646_1170	COG0521	Mo-molybdopterin cofactor biosynthetic process
N646_1171	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N646_1172	COG0391	Required for morphogenesis under gluconeogenic growth conditions
N646_1173	COG2198	Histidine kinase
N646_1174	COG2204	response regulator
N646_1175	COG0556	nucleotide-excision repair
N646_1176	COG1882	Formate acetyltransferase
N646_1177	COG4657	Part of a membrane complex involved in electron transport
N646_1178	COG2878	Part of a membrane complex involved in electron transport
N646_1179	COG4656	Part of a membrane complex involved in electron transport
N646_1180	COG4658	electron transport chain
N646_1181	COG4659	FMN binding
N646_1182	COG4660	Part of a membrane complex involved in electron transport
N646_1183	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N646_1184	COG0346	lactoylglutathione lyase activity
N646_1186	COG2885	chlorophyll binding
N646_1188	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N646_1189	COG2056	Na+-H+ antiporter family
N646_1216	COG4695	Portal protein
N646_1233	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
N646_1236	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
N646_1240	COG1012	belongs to the aldehyde dehydrogenase family
N646_1240	COG1454	alcohol dehydrogenase
N646_1241	COG2095	MarC family integral membrane protein
N646_1242	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N646_1243	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N646_1244	COG1757	Na H antiporter
N646_1247	COG3081	Nucleoid-associated protein
N646_1248	COG3082	Protein of unknown function (DUF1414)
N646_1249	COG3083	sulfuric ester hydrolase activity
N646_1250	COG0123	including yeast histone deacetylase and acetoin utilization protein
N646_1255	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N646_1256	COG0778	Nitroreductase
N646_1258	COG1902	pentaerythritol trinitrate reductase activity
N646_1258	COG0446	pyridine nucleotide-disulphide oxidoreductase
N646_1259	COG0616	signal peptide processing
N646_1260	COG0252	asparaginase activity
N646_1261	COG3139	Protein of unknown function (DUF1315)
N646_1263	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N646_1264	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N646_1267	COG2226	methyltransferase
N646_1271	COG1785	Belongs to the alkaline phosphatase family
N646_1273	COG0346	lactoylglutathione lyase activity
N646_1274	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
N646_1275	COG0668	transmembrane transport
N646_1276	COG2983	Belongs to the UPF0260 family
N646_1277	COG2261	transglycosylase associated protein
N646_1279	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N646_1281	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
N646_1283	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N646_1286	COG0745	RESPONSE REGULATOR receiver
N646_1287	COG0583	DNA-binding transcription factor activity
N646_1288	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
N646_1289	COG1286	toxin biosynthetic process
N646_1290	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
N646_1291	COG0285	dihydrofolate synthase activity
N646_1292	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
N646_1293	COG0101	tRNA pseudouridine synthase activity
N646_1295	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N646_1296	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N646_1297	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N646_1298	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
N646_1298	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N646_1299	COG0431	NADPH-dependent FMN reductase
N646_1302	COG3101	peptidyl-lysine hydroxylation
N646_1303	COG2860	membrane
N646_1304	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
N646_1305	COG2890	protein-(glutamine-N5) methyltransferase activity
N646_1306	COG2840	Smr protein MutS2
N646_1307	COG2062	phosphohistidine phosphatase, SixA
N646_1310	COG1250	3-hydroxyacyl-CoA dehydrogenase
N646_1310	COG1024	Enoyl-CoA hydratase
N646_1311	COG0183	Belongs to the thiolase family
N646_1316	COG2067	long-chain fatty acid transport protein
N646_1318	COG3088	subunit of a heme lyase
N646_1318	COG4235	cytochrome complex assembly
N646_1320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N646_1321	COG1138	Cytochrome C-type biogenesis protein
N646_1322	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
N646_1323	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N646_1324	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N646_1325	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N646_1326	COG4133	protoheme IX ABC transporter activity
N646_1329	COG0835	chemotaxis
N646_1331	COG1192	Involved in chromosome partitioning
N646_1332	COG2201	protein-glutamate methylesterase activity
N646_1333	COG2198	Histidine kinase
N646_1333	COG0643	Histidine kinase
N646_1334	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
N646_1337	COG0455	bacterial-type flagellum organization
N646_1341	COG1684	flagellar biosynthetic protein fliR
N646_1342	COG1987	bacterial-type flagellum assembly
N646_1355	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N646_1357	COG1677	Flagellar hook-basal body complex protein FliE
N646_1358	COG2204	response regulator
N646_1359	COG4191	Histidine kinase
N646_1360	COG2204	response regulator
N646_1361	COG1516	flagellar protein fliS
N646_1363	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
N646_1364	COG1334	flagellar protein FlaG
N646_1365	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N646_1366	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N646_1367	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N646_1368	COG2837	iron assimilation
N646_1373	COG1393	Belongs to the ArsC family
N646_1374	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N646_1378	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N646_1380	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
N646_1383	COG4783	chaperone-mediated protein folding
N646_1384	COG1393	Belongs to the ArsC family
N646_1388	COG2233	PERMEase
N646_1389	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
N646_1390	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
N646_1391	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
N646_1393	COG0121	glutamine amidotransferase
N646_1394	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
N646_1395	COG1960	acyl-CoA dehydrogenase activity
N646_1401	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N646_1402	COG0328	RNA-DNA hybrid ribonuclease activity
N646_1403	COG2226	methyltransferase
N646_1404	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N646_1405	COG1388	LysM domain
N646_1405	COG0741	lytic transglycosylase activity
N646_1407	COG3021	interspecies interaction between organisms
N646_1408	COG0347	Belongs to the P(II) protein family
N646_1411	COG0825	malonyl-CoA metabolic process
N646_1412	COG0587	DNA-directed DNA polymerase activity
N646_1414	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N646_1415	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N646_1418	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N646_1419	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
N646_1421	COG0750	zinc metalloprotease
N646_1422	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
N646_1423	COG0575	Belongs to the CDS family
N646_1424	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N646_1425	COG0233	cytoplasmic translational termination
N646_1426	COG0528	UMP kinase activity
N646_1427	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
N646_1428	COG0052	Belongs to the universal ribosomal protein uS2 family
N646_1429	COG0024	Methionine aminopeptidase
N646_1430	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
N646_1432	COG0564	pseudouridine synthase activity
N646_1439	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N646_1440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N646_1445	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
N646_1446	COG0254	rRNA binding
N646_1447	COG1720	tRNA m6t6A37 methyltransferase activity
N646_1448	COG0442	prolyl-tRNA aminoacylation
N646_1452	COG0733	neurotransmitter:sodium symporter activity
N646_1456	COG0514	ATP-dependent DNA helicase (RecQ)
N646_1457	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N646_1459	COG3706	GGDEF domain
N646_1459	COG0745	RESPONSE REGULATOR receiver
N646_1461	COG1477	protein flavinylation
N646_1462	COG1477	protein flavinylation
N646_1463	COG2871	sodium ion transport
N646_1464	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
N646_1465	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
N646_1466	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
N646_1467	COG1805	sodium ion transport
N646_1468	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
N646_1469	COG0271	Belongs to the BolA IbaG family
N646_1470	COG2813	Specifically methylates the guanine in position
N646_1471	COG3056	Lipoprotein
N646_1475	COG1595	DNA-templated transcription, initiation
N646_1478	COG3248	Nucleoside-binding outer membrane protein
N646_1479	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
N646_1480	COG0693	protein deglycase activity
N646_1481	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N646_1482	COG3706	GGDEF domain
N646_1483	COG2166	iron-sulfur cluster assembly
N646_1484	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
N646_1485	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
N646_1487	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
N646_1487	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N646_1490	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N646_1491	COG1074	ATP-dependent DNA helicase activity
N646_1492	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
N646_1496	COG3141	response to X-ray
N646_1499	COG2171	N-acyltransferase activity
N646_1500	COG0584	glycerophosphoryl diester phosphodiesterase
N646_1501	COG2271	Major facilitator Superfamily
N646_1502	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N646_1503	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N646_1504	COG1349	DNA-binding transcription factor activity
N646_1505	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
N646_1506	COG0598	Magnesium transport protein CorA
N646_1507	COG1943	Transposase
N646_1511	COG1609	Transcriptional regulator
N646_1512	COG0583	DNA-binding transcription factor activity
N646_1520	COG1022	Amp-dependent synthetase and ligase
N646_1521	COG0583	DNA-binding transcription factor activity
N646_1522	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N646_1523	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
N646_1525	COG0560	Phosphoserine phosphatase
N646_1527	COG0813	purine-nucleoside phosphorylase activity
N646_1528	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
N646_1529	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
N646_1530	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
N646_1532	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
N646_1533	COG0084	hydrolase, TatD family'
N646_1539	COG3153	acetyltransferase
N646_1545	COG0534	Mate efflux family protein
N646_1548	COG1185	polyribonucleotide nucleotidyltransferase activity
N646_1549	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
N646_1550	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
N646_1551	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
N646_1552	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
N646_1553	COG0195	Participates in both transcription termination and antitermination
N646_1554	COG0779	Required for maturation of 30S ribosomal subunits
N646_1555	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N646_1556	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N646_1557	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N646_1558	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N646_1559	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
N646_1560	COG1534	Rna-binding protein
N646_1561	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N646_1562	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
N646_1563	COG2027	D-alanyl-D-alanine carboxypeptidase
N646_1566	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N646_1567	COG0739	heme binding
N646_1573	COG0628	permease
N646_1576	COG0747	negative chemotaxis
N646_1578	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N646_1579	COG0444	Belongs to the ABC transporter superfamily
N646_1580	COG4608	Belongs to the ABC transporter superfamily
N646_1582	COG2971	BadF BadG BcrA BcrD
N646_1585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N646_1586	COG3842	ATPase activity
N646_1588	COG1840	ABC-type Fe3 transport system, periplasmic component
N646_1589	COG0004	ammonium transporteR
N646_1591	COG3112	Uncharacterised protein family (UPF0231)
N646_1592	COG1049	propionate catabolic process, 2-methylcitrate cycle
N646_1593	COG1752	Esterase of the alpha-beta hydrolase superfamily
N646_1594	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N646_1595	COG1643	Atp-dependent helicase
N646_1596	COG1489	DNA binding
N646_1597	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
N646_1598	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N646_1600	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N646_1601	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
N646_1602	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
N646_1603	COG1560	Kdo2-lipid A biosynthetic process
N646_1604	COG0842	Transport permease protein
N646_1605	COG1131	(ABC) transporter
N646_1606	COG0659	secondary active sulfate transmembrane transporter activity
N646_1607	COG0288	reversible hydration of carbon dioxide
N646_1610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N646_1611	COG0508	dehydrogenase complex catalyzes the overall conversion of
N646_1612	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
N646_1613	COG2186	Transcriptional regulator
N646_1615	COG0157	Belongs to the NadC ModD family
N646_1617	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N646_1618	COG1459	type II secretion system
N646_1620	COG0237	dephospho-CoA kinase activity
N646_1621	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
N646_1622	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
N646_1625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
N646_1626	COG0228	four-way junction DNA binding
N646_1627	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N646_1628	COG4137	Cytochrome C assembly protein
N646_1629	COG4536	flavin adenine dinucleotide binding
N646_1630	COG1854	S-ribosylhomocysteine lyase activity
N646_1633	COG0612	Peptidase, M16
N646_1634	COG1238	metal cluster binding
N646_1636	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
N646_1637	COG0511	ligase activity, forming carbon-carbon bonds
N646_1637	COG5016	pyruvate
N646_1641	COG0527	aspartate kinase activity
N646_1642	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N646_1643	COG2137	regulation of response to DNA damage stimulus
N646_1644	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
N646_1645	COG1546	Belongs to the CinA family
N646_1646	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
N646_1647	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N646_1649	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
N646_1650	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
N646_1652	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
N646_1653	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
N646_1654	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
N646_1655	COG0148	phosphopyruvate hydratase activity
N646_1656	COG0504	CTP synthase activity
N646_1657	COG3956	TIGRFAM MazG family protein
N646_1658	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N646_1659	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N646_1661	COG0736	holo-[acyl-carrier-protein] synthase activity
N646_1662	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
N646_1663	COG1381	Involved in DNA repair and RecF pathway recombination
N646_1664	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N646_1666	COG0681	Belongs to the peptidase S26 family
N646_1667	COG0481	GTPase activity
N646_1668	COG3086	response to oxidative stress
N646_1671	COG1595	DNA-templated transcription, initiation
N646_1672	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
N646_1674	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
N646_1677	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N646_1678	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N646_1679	COG3079	Belongs to the UPF0149 family
N646_1680	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
N646_1681	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N646_1682	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
N646_1683	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N646_1685	COG0583	DNA-binding transcription factor activity
N646_1688	COG0668	transmembrane transport
N646_1689	COG0191	fructose-bisphosphate aldolase activity
N646_1692	COG4771	TonB-dependent receptor
N646_1693	COG0583	DNA-binding transcription factor activity
N646_1694	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
N646_1695	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
N646_1699	COG2356	endonuclease I
N646_1700	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N646_1701	COG0189	ligase activity
N646_1702	COG1678	Uncharacterized ACR, COG1678
N646_1703	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
N646_1706	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
N646_1707	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
N646_1708	COG0762	integral membrane protein
N646_1709	COG1872	DUF167
N646_1711	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N646_1712	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N646_1713	COG2066	Belongs to the glutaminase family
N646_1715	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N646_1717	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
N646_1719	COG0840	transmembrane signaling receptor activity
N646_1724	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
N646_1726	COG3394	polysaccharide catabolic process
N646_1727	COG1486	melibiose metabolic process
N646_1728	COG1447	Phosphotransferase system cellobiose-specific component IIA
N646_1729	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N646_1731	COG0726	polysaccharide deacetylase
N646_1732	COG1028	Short-chain dehydrogenase reductase Sdr
N646_1733	COG4325	translation initiation factor activity
N646_1735	COG0795	lipopolysaccharide-transporting ATPase activity
N646_1736	COG0795	lipopolysaccharide-transporting ATPase activity
N646_1737	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N646_1738	COG2927	DNA polymerase III (CHI subunit)
N646_1739	COG0525	valine-tRNA ligase activity
N646_1741	COG0456	acetyltransferase
N646_1746	COG0540	Belongs to the ATCase OTCase family
N646_1747	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
N646_1748	COG0251	oxidation-reduction process
N646_1749	COG0204	Acyl-transferase
N646_1750	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N646_1751	COG5007	Belongs to the BolA IbaG family
N646_1753	COG2854	intermembrane phospholipid transfer
N646_1754	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
N646_1755	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
N646_1756	COG1127	ABC transporter
N646_1758	COG0517	IMP dehydrogenase activity
N646_1758	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
N646_1760	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
N646_1761	COG1137	ATPase activity
N646_1763	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
N646_1764	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N646_1765	COG1660	Displays ATPase and GTPase activities
N646_1766	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N646_1767	COG2239	Acts as a magnesium transporter
N646_1768	COG0312	modulator of DNA gyrase
N646_1769	COG3028	Belongs to the UPF0307 family
N646_1770	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N646_1771	COG0564	pseudouridine synthase activity
N646_1773	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N646_1774	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
N646_1775	COG0312	modulator of DNA gyrase
N646_1776	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N646_1777	COG3164	Protein of unknown function
N646_1778	COG1530	ribonuclease E activity
N646_1779	COG0424	maF-like protein
N646_1780	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
N646_1781	COG1792	Involved in formation and maintenance of cell shape
N646_1782	COG1077	Cell shape determining protein MreB Mrl
N646_1791	COG1459	type II secretion system
N646_1792	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N646_1794	COG3267	Type II secretory pathway component ExeA
N646_1794	COG3409	Peptidoglycan-binding domain 1 protein
N646_1795	COG1450	Type ii and iii secretion system protein
N646_1799	COG2199	diguanylate cyclase activity
N646_1799	COG2200	EAL domain
N646_1800	COG0629	single-stranded DNA binding
N646_1803	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N646_1805	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
N646_1807	COG0527	aspartate kinase activity
N646_1808	COG0646	methionine synthase
N646_1808	COG1410	methionine synthase
N646_1816	COG0175	sulfate reduction
N646_1817	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N646_1818	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
N646_1822	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N646_1824	COG0735	belongs to the Fur family
N646_1826	COG0166	Belongs to the GPI family
N646_1827	COG0432	Pfam Uncharacterised protein family UPF0047
N646_1828	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N646_1829	COG0305	Participates in initiation and elongation during chromosome replication
N646_1834	COG0360	Binds together with S18 to 16S ribosomal RNA
N646_1835	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N646_1836	COG0338	D12 class N6 adenine-specific DNA methyltransferase
N646_1838	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
N646_1839	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
N646_1845	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
N646_1847	COG0678	peroxiredoxin activity
N646_1847	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N646_1848	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N646_1851	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
N646_1851	COG0165	Argininosuccinate lyase
N646_1852	COG0137	argininosuccinate synthase activity
N646_1854	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
N646_1856	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
N646_1858	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
N646_1859	COG0460	homoserine dehydrogenase
N646_1859	COG0527	aspartate kinase activity
N646_1860	COG0626	cystathionine gamma-synthase activity
N646_1862	COG0281	malic enzyme
N646_1864	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N646_1865	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N646_1869	COG2923	Belongs to the DsrF TusC family
N646_1870	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
N646_1871	COG2964	Protein conserved in bacteria
N646_1872	COG0545	Peptidyl-prolyl cis-trans isomerase
N646_1875	COG1446	asparaginase
N646_1876	COG1047	Peptidyl-prolyl cis-trans
N646_1879	COG2249	NAD(P)H dehydrogenase (quinone) activity
N646_1880	COG0488	(ABC) transporter
N646_1882	COG0429	hydrolase of the alpha beta-hydrolase fold
N646_1884	COG3954	Phosphoribulokinase
N646_1885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N646_1889	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N646_1890	COG0512	Glutamine amidotransferase of anthranilate synthase
N646_1894	COG0180	Tryptophanyl-tRNA synthetase
N646_1895	COG0546	phosphoglycolate phosphatase activity
N646_1896	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N646_1897	COG0557	exoribonuclease II activity
N646_1898	COG1959	2 iron, 2 sulfur cluster binding
N646_1899	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N646_1899	COG1017	nitric oxide dioxygenase activity
N646_1900	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
N646_1901	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N646_1902	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
N646_1903	COG0330	HflC and HflK could
N646_1904	COG0330	HflC and HflK could
N646_1905	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N646_1907	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
N646_1908	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
N646_1911	COG0802	atpase or kinase
N646_1913	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
N646_1914	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
N646_1915	COG1162	GTPase activity
N646_1916	COG0688	phosphatidylethanolamine metabolic process
N646_1917	COG0471	metal ion transport
N646_1917	COG3273	potassium ion transport
N646_1919	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
N646_1920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N646_1921	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
N646_1922	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
N646_1923	COG1045	serine acetyltransferase
N646_1924	COG4942	peptidase
N646_1928	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
N646_1929	COG1053	succinate dehydrogenase
N646_1930	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N646_1931	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
N646_1932	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
N646_1935	COG1509	lysine 2,3-aminomutase activity
N646_1936	COG1285	pathogenesis
N646_1939	COG0459	protein refolding
N646_1940	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
N646_1941	COG0534	Mate efflux family protein
N646_1942	COG1943	Transposase
N646_1943	COG0205	6-phosphofructokinase activity
N646_1944	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
N646_1945	COG3678	ATP-independent chaperone mediated protein folding
N646_1946	COG0745	RESPONSE REGULATOR receiver
N646_1947	COG2205	protein histidine kinase activity
N646_1949	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
N646_1950	COG3030	protein affecting phage T7 exclusion by the F plasmid
N646_1951	COG1027	Aspartate ammonia-lyase
N646_1952	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
N646_1953	COG4232	protein-disulfide reductase activity
N646_1955	COG3263	regulation of cellular component size
N646_1957	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N646_1962	COG2814	Major facilitator Superfamily
N646_1965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N646_1966	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
N646_1967	COG0511	ligase activity, forming carbon-carbon bonds
N646_1968	COG0439	Biotin carboxylase
N646_1969	COG2264	protein methyltransferase activity
N646_1970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N646_1971	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
N646_1973	COG0488	(ABC) transporter
N646_1979	COG1982	Orn Lys Arg decarboxylase major
N646_1980	COG0531	amino acid
N646_1981	COG3710	Transcriptional regulator
N646_1982	COG0789	Transcriptional regulator
N646_1985	COG0151	Belongs to the GarS family
N646_1988	COG1253	flavin adenine dinucleotide binding
N646_1989	COG3068	Protein conserved in bacteria
N646_1991	COG1573	uracil-dna glycosylase
N646_1992	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
N646_1993	COG2816	NAD+ diphosphatase activity
N646_1994	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
N646_1995	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N646_1996	COG0085	RNA polymerase activity
N646_1997	COG0222	ribosome binding
N646_1998	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
N646_2001	COG0250	Participates in transcription elongation, termination and antitermination
N646_2002	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N646_2003	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N646_2005	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
N646_2005	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
N646_2006	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N646_2008	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N646_2015	COG4206	TonB-dependent receptor
N646_2024	COG3339	Conserved Protein
N646_2028	COG2003	Belongs to the UPF0758 family
N646_2039	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N646_2040	COG0534	Mate efflux family protein
N646_2041	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
N646_2042	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
N646_2043	COG2937	Belongs to the GPAT DAPAT family
N646_2044	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
N646_2045	COG3161	chorismate lyase activity
N646_2046	COG1580	Controls the rotational direction of flagella during chemotaxis
N646_2047	COG0705	Rhomboid family
N646_2048	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N646_2050	COG2177	Part of the ABC transporter FtsEX involved in
N646_2051	COG2884	Cell division ATP-binding protein ftsE
N646_2052	COG0552	protein localization to endoplasmic reticulum
N646_2053	COG0742	ribosomal rna small subunit methyltransferase
N646_2055	COG2095	MarC family integral membrane protein
N646_2065	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N646_2066	COG0640	Transcriptional regulator
N646_2067	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
N646_2068	COG1280	lysine exporter protein (LysE YggA)
N646_2069	COG2267	carboxylic ester hydrolase activity
N646_2070	COG0561	phosphatase activity
N646_2075	COG2200	EAL domain
N646_2075	COG3287	FIST C domain
N646_2075	COG2199	diguanylate cyclase activity
N646_2076	COG1011	Hydrolase
N646_2077	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
N646_2080	COG0019	diaminopimelate decarboxylase activity
N646_2082	COG1965	Belongs to the frataxin family
N646_2083	COG3072	Adenylate cyclase
N646_2084	COG0181	hydroxymethylbilane synthase activity
N646_2085	COG1587	Uroporphyrinogen-III synthase
N646_2086	COG2959	enzyme of heme biosynthesis
N646_2087	COG3071	HemY protein
N646_2092	COG0633	Ferredoxin
N646_2093	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
N646_2095	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
N646_2096	COG3118	belongs to the thioredoxin family
N646_2097	COG0513	Belongs to the DEAD box helicase family
N646_2098	COG0248	Ppx GppA phosphatase
N646_2100	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
N646_2102	COG0514	ATP-dependent DNA helicase (RecQ)
N646_2103	COG2962	Rard protein
N646_2105	COG1280	lysine exporter protein (LysE YggA)
N646_2106	COG0405	Gamma-glutamyltransferase
N646_2108	COG0210	DNA helicase
N646_2110	COG3220	belongs to the UPF0276 family
N646_2116	COG0006	proline dipeptidase activity
N646_2116	COG0006	proline dipeptidase activity
N646_2119	COG2104	thiamine diphosphate biosynthetic process
N646_2120	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
N646_2124	COG2132	Multicopper oxidase
N646_2129	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
N646_2133	COG0009	L-threonylcarbamoyladenylate synthase
N646_2134	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
N646_2135	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
N646_2136	COG0551	DNA topoisomerase type I activity
N646_2137	COG2922	Belongs to the Smg family
N646_2138	COG0758	DNA mediated transformation
N646_2140	COG0242	peptide deformylase activity
N646_2141	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
N646_2142	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N646_2142	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N646_2143	COG0569	domain protein
N646_2144	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N646_2146	COG1272	protein, Hemolysin III
N646_2147	COG4326	sporulation control protein
N646_2150	COG3084	Protein conserved in bacteria
N646_2152	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
N646_2153	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N646_2155	COG0204	Acyl-transferase
N646_2157	COG0606	chelatase, subunit chli
N646_2159	COG3978	acetolactate synthase activity
N646_2160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N646_2161	COG0129	dihydroxy-acid dehydratase activity
N646_2163	COG0583	DNA-binding transcription factor activity
N646_2164	COG2814	Major facilitator Superfamily
N646_2165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N646_2166	COG0765	amino acid transport
N646_2168	COG0355	proton-transporting ATP synthase activity, rotational mechanism
N646_2169	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
N646_2170	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
N646_2171	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
N646_2172	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N646_2173	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
N646_2175	COG0356	it plays a direct role in the translocation of protons across the membrane
N646_2176	COG3312	ion transport
N646_2177	COG1475	DNA binding
N646_2178	COG1192	Involved in chromosome partitioning
N646_2179	COG0357	Ribosomal RNA small subunit methyltransferase G
N646_2180	COG0445	tRNA wobble uridine modification
N646_2181	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
N646_2183	COG0706	membrane insertase activity
N646_2184	COG0594	ribonuclease P activity
N646_2186	COG1126	abc transporter atp-binding protein
N646_2189	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N646_2190	COG0592	DNA-directed DNA polymerase activity
N646_2192	COG0187	DNA topoisomerase II activity
N646_2193	COG1943	Transposase
N646_2196	COG0071	Belongs to the small heat shock protein (HSP20) family
N646_2197	COG3977	Valine--pyruvate aminotransferase
N646_2198	COG0366	Alpha amylase catalytic
N646_2202	COG2119	membrane
N646_2204	COG0425	Belongs to the sulfur carrier protein TusA family
N646_2207	COG0604	alcohol dehydrogenase
N646_2209	COG0183	Belongs to the thiolase family
N646_2211	COG1739	Uncharacterized protein family UPF0029
N646_2212	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N646_2218	COG0583	DNA-binding transcription factor activity
N646_2219	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
N646_2220	COG2960	long-chain fatty acid transporting porin activity
N646_2221	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N646_2222	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N646_2227	COG4172	Belongs to the ABC transporter superfamily
N646_2228	COG4166	transmembrane transport
N646_2230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N646_2239	COG1609	Transcriptional regulator
N646_2240	COG0583	DNA-binding transcription factor activity
N646_2242	COG2076	Multidrug Resistance protein
N646_2243	COG0129	dihydroxy-acid dehydratase activity
N646_2244	COG3265	gluconokinase activity
N646_2245	COG2610	gluconate transmembrane transporter activity
N646_2246	COG0800	Aldolase
N646_2247	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
N646_2248	COG0583	DNA-binding transcription factor activity
N646_2256	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N646_2257	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
N646_2259	COG1522	sequence-specific DNA binding
N646_2260	COG5002	protein histidine kinase activity
N646_2260	COG5001	Diguanylate cyclase
N646_2261	COG0742	ribosomal rna small subunit methyltransferase
N646_2263	COG0697	spore germination
N646_2264	COG0589	response to stress
N646_2265	COG1528	Iron-storage protein
N646_2267	COG2081	HI0933 family
N646_2273	COG1597	lipid kinase activity
N646_2280	COG0628	permease
N646_2283	COG1322	Protein conserved in bacteria
N646_2284	COG2226	methyltransferase
N646_2285	COG3165	ubiquinone biosynthetic process from chorismate
N646_2286	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N646_2289	COG0805	protein transport
N646_2293	COG0084	hydrolase, TatD family'
N646_2295	COG0456	acetyltransferase
N646_2296	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N646_2296	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N646_2297	COG0218	Necessary for normal cell division and for the maintenance of normal septation
N646_2302	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N646_2303	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N646_2305	COG2204	response regulator
N646_2306	COG3852	Histidine kinase
N646_2308	COG0174	glutamine synthetase
N646_2312	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N646_2314	COG1295	ribonuclease BN
N646_2315	COG1490	D-aminoacyl-tRNA deacylase activity
N646_2316	COG0456	acetyltransferase
N646_2318	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
N646_2319	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
N646_2320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
N646_2321	COG3031	protein transport across the cell outer membrane
N646_2323	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N646_2324	COG1459	type II secretion system
N646_2325	COG2165	general secretion pathway protein
N646_2326	COG2165	general secretion pathway protein
N646_2327	COG2165	general secretion pathway protein
N646_2328	COG4795	General secretion pathway protein
N646_2329	COG3156	type II secretion system protein K
N646_2330	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
N646_2331	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
N646_2333	COG1218	3'(2'),5'-bisphosphate nucleotidase
N646_2334	COG0494	nUDIX hydrolase
N646_2337	COG1040	competence protein
N646_2340	COG2183	response to ionizing radiation
N646_2342	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N646_2344	COG0745	RESPONSE REGULATOR receiver
N646_2345	COG2205	protein histidine kinase activity
N646_2346	COG2233	PERMEase
N646_2347	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N646_2348	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N646_2349	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N646_2351	COG1758	RNA polymerase activity
N646_2352	COG0194	GDP metabolic process
N646_2355	COG0848	biopolymer transport protein
N646_2356	COG0811	peptide transport
N646_2360	COG4174	ABC transporter (Permease)
N646_2361	COG4239	(ABC) transporter, permease
N646_2362	COG0747	negative chemotaxis
N646_2363	COG0444	Belongs to the ABC transporter superfamily
N646_2364	COG4608	Belongs to the ABC transporter superfamily
N646_2366	COG1561	YicC-like family, N-terminal region
N646_2367	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
N646_2369	COG1560	Kdo2-lipid A biosynthetic process
N646_2370	COG1309	transcriptional regulator
N646_2371	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N646_2373	COG2003	Belongs to the UPF0758 family
N646_2378	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
N646_2381	COG0463	Glycosyl transferase, family 2
N646_2382	COG0859	PFAM glycosyl transferase family 9
N646_2383	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
N646_2384	COG3642	lipopolysaccharide core region biosynthetic process
N646_2386	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
N646_2394	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N646_2395	COG1519	Transferase
N646_2396	COG0859	PFAM glycosyl transferase family 9
N646_2398	COG1560	Kdo2-lipid A biosynthetic process
N646_2400	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N646_2407	COG2244	polysaccharide biosynthetic process
N646_2410	COG0438	transferase activity, transferring glycosyl groups
N646_2415	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N646_2417	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N646_2419	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N646_2422	COG0438	transferase activity, transferring glycosyl groups
N646_2429	COG0149	triose-phosphate isomerase activity
N646_2431	COG3152	Membrane
N646_2436	COG1494	fructose-1,6-bisphosphatase
N646_2439	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N646_2440	COG1575	Belongs to the MenA family. Type 1 subfamily
N646_2441	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
N646_2442	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
N646_2444	COG1609	Transcriptional regulator
N646_2445	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
N646_2446	COG0254	rRNA binding
N646_2448	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
N646_2449	COG0088	Forms part of the polypeptide exit tunnel
N646_2451	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
N646_2452	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N646_2453	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
N646_2454	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
N646_2456	COG0255	Belongs to the universal ribosomal protein uL29 family
N646_2457	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
N646_2459	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
N646_2460	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
N646_2462	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
N646_2463	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
N646_2466	COG1841	ribosomal large subunit assembly
N646_2468	COG0201	protein transport
N646_2470	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N646_2471	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
N646_2473	COG0202	RNA polymerase activity
N646_2474	COG0203	ribosomal protein L17
N646_2476	COG0545	Peptidyl-prolyl cis-trans isomerase
N646_2478	COG2153	protein acetylation
N646_2479	COG0513	Belongs to the DEAD box helicase family
N646_2482	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
N646_2482	COG1648	precorrin-2 dehydrogenase activity
N646_2483	COG0175	sulfate reduction
N646_2484	COG2895	sulfate adenylyltransferase (ATP) activity
N646_2485	COG0471	metal ion transport
N646_2485	COG3273	potassium ion transport
N646_2486	COG0529	Catalyzes the synthesis of activated sulfate
N646_2490	COG4181	ATPase activity
N646_2493	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
N646_2495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N646_2496	COG0729	surface antigen
N646_2497	COG2911	Protein conserved in bacteria
N646_2498	COG2105	PFAM AIG2 family protein
N646_2500	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
N646_2501	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
N646_2503	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N646_2504	COG0163	prenyltransferase activity
N646_2505	COG4143	(ABC) transporter
N646_2506	COG1178	ABC-type Fe3 transport system permease component
N646_2507	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
N646_2508	COG0583	DNA-binding transcription factor activity
N646_2509	COG1902	pentaerythritol trinitrate reductase activity
N646_2516	COG0142	geranyltranstransferase activity
N646_2517	COG0261	This protein binds to 23S rRNA in the presence of protein L20
N646_2519	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N646_2520	COG2966	Psort location CytoplasmicMembrane, score
N646_2522	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
N646_2523	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
N646_2524	COG2967	ApaG domain
N646_2525	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N646_2526	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
N646_2527	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N646_2528	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
N646_2529	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
N646_2533	COG0473	3-isopropylmalate dehydrogenase activity
N646_2534	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N646_2539	COG0583	DNA-binding transcription factor activity
N646_2540	COG1022	Amp-dependent synthetase and ligase
N646_2541	COG0028	Belongs to the TPP enzyme family
N646_2542	COG0440	acetolactate synthase activity
N646_2543	COG3706	GGDEF domain
N646_2545	COG0469	pyruvate kinase activity
N646_2546	COG1349	DNA-binding transcription factor activity
N646_2547	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N646_2549	COG2376	Dihydroxyacetone kinase
N646_2550	COG1461	Dihydroxyacetone kinase
N646_2553	COG3722	fumarate hydratase activity
N646_2555	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
N646_2555	COG2213	PTS system mannitol-specific
N646_2559	COG1464	Belongs to the NlpA lipoprotein family
N646_2560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N646_2561	COG0358	DNA primase activity
N646_2562	COG1610	YqeY-like protein
N646_2563	COG0828	Belongs to the bacterial ribosomal protein bS21 family
N646_2564	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
N646_2565	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N646_2566	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
N646_2567	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
N646_2568	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N646_2569	COG1968	undecaprenyl-diphosphatase activity
N646_2571	COG3409	Peptidoglycan-binding domain 1 protein
N646_2571	COG3267	Type II secretory pathway component ExeA
N646_2574	COG0405	Gamma-glutamyltransferase
N646_2576	COG4991	sh3 domain protein
N646_2577	COG0306	phosphate transporter
N646_2578	COG1392	Phosphate transport regulator
N646_2579	COG3025	triphosphatase activity
N646_2582	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
N646_2583	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
N646_2583	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
N646_2584	COG1538	Outer membrane efflux protein
N646_2585	COG0494	nUDIX hydrolase
N646_2586	COG3151	Protein conserved in bacteria
N646_2588	COG3150	esterase
N646_2589	COG0187	DNA topoisomerase II activity
N646_2590	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N646_2591	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N646_2593	COG3105	Protein conserved in bacteria
N646_2594	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
N646_2596	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N646_2597	COG0723	plastoquinol--plastocyanin reductase activity
N646_2598	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
N646_2599	COG2857	Cytochrome c1
N646_2600	COG0625	glutathione transferase activity
N646_2601	COG2969	positive regulation of protein catabolic process
N646_2602	COG2823	Periplasmic or secreted lipoprotein
N646_2603	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
N646_2606	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
N646_2608	COG3116	cell division
N646_2609	COG0768	penicillin binding
N646_2610	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N646_2611	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N646_2612	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N646_2613	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
N646_2614	COG0772	Belongs to the SEDS family
N646_2617	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
N646_2618	COG0849	cell division
N646_2619	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N646_2620	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
N646_2622	COG0653	protein targeting
N646_2623	COG0494	nUDIX hydrolase
N646_2625	COG0505	Belongs to the CarA family
N646_2626	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N646_2629	COG0730	response to heat
N646_2630	COG2860	membrane
N646_2633	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
N646_2635	COG0493	'glutamate synthase
N646_2636	COG0070	glutamate synthase
N646_2636	COG0069	glutamate synthase activity
N646_2636	COG0067	glutamate synthase
N646_2638	COG0069	glutamate synthase activity
N646_2638	COG0067	glutamate synthase
N646_2638	COG0070	glutamate synthase
N646_2639	COG1242	4 iron, 4 sulfur cluster binding
N646_2640	COG5001	Diguanylate cyclase
N646_2640	COG3706	GGDEF domain
N646_2640	COG4251	negative regulation of phosphorylation
N646_2640	COG2203	Gaf domain
N646_2641	COG2198	Histidine kinase
N646_2641	COG0784	Response regulator, receiver
N646_2641	COG5002	protein histidine kinase activity
N646_2643	COG0745	RESPONSE REGULATOR receiver
N646_2645	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N646_2648	COG0083	homoserine kinase activity
N646_2649	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
N646_2651	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
N646_2652	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
N646_2653	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
N646_2656	COG1115	amino acid carrier protein
N646_2657	COG3022	response to hydroperoxide
N646_2658	COG0513	Belongs to the DEAD box helicase family
N646_2659	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
N646_2661	COG0716	FMN binding
N646_2663	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N646_2664	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
N646_2665	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
N646_2667	COG2204	response regulator
N646_2669	COG0667	Aldo Keto reductase
N646_2675	COG0730	response to heat
N646_2677	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
N646_2679	COG1283	sodium-dependent phosphate transmembrane transporter activity
N646_2680	COG0583	DNA-binding transcription factor activity
N646_2681	COG0640	Transcriptional regulator
N646_2682	COG0268	Binds directly to 16S ribosomal RNA
N646_2683	COG0728	peptidoglycan biosynthetic process
N646_2684	COG0196	riboflavin kinase activity
N646_2688	COG1047	Peptidyl-prolyl cis-trans
N646_2689	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
N646_2691	COG3279	Response regulator of the LytR AlgR family
N646_2692	COG3275	phosphorelay sensor kinase activity
N646_2693	COG1966	Carbon starvation protein
N646_2697	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
N646_2698	COG1472	Belongs to the glycosyl hydrolase 3 family
N646_2699	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N646_2700	COG1605	Chorismate mutase
N646_2700	COG0287	Prephenate dehydrogenase
N646_2701	COG0739	heme binding
N646_2703	COG0488	(ABC) transporter
N646_2705	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
N646_2706	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
N646_2707	COG1605	Chorismate mutase
N646_2707	COG0077	Prephenate dehydratase
N646_2710	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
N646_2711	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
N646_2712	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N646_2713	COG0564	pseudouridine synthase activity
N646_2715	COG0542	response to heat
N646_2721	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
N646_2723	COG2974	May be involved in recombination
N646_2724	COG0745	RESPONSE REGULATOR receiver
N646_2725	COG5002	protein histidine kinase activity
N646_2727	COG1943	Transposase
N646_2728	COG0248	Ppx GppA phosphatase
N646_2729	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
N646_2730	COG0573	inorganic phosphate transmembrane transporter activity
N646_2731	COG0581	inorganic phosphate transmembrane transporter activity
N646_2732	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N646_2733	COG0704	Plays a role in the regulation of phosphate uptake
N646_2735	COG3142	Participates in the control of copper homeostasis
N646_2737	COG0450	alkyl hydroperoxide reductase
N646_2738	COG0583	DNA-binding transcription factor activity
N646_2740	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
N646_2742	COG0517	IMP dehydrogenase activity
N646_2744	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
N646_2746	COG1862	Preprotein translocase
N646_2747	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N646_2748	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N646_2751	COG0483	inositol monophosphate 1-phosphatase activity
N646_2752	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
N646_2755	COG0822	iron-sulfur transferase activity
N646_2758	COG0443	Heat shock 70 kDa protein
N646_2759	COG0633	Ferredoxin
N646_2760	COG2975	iron-sulfur cluster assembly
N646_2762	COG0105	UTP biosynthetic process
N646_2765	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
N646_2766	COG0124	histidyl-tRNA synthetase
N646_2767	COG2976	Protein conserved in bacteria
N646_2768	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N646_2769	COG1160	GTP binding
N646_2772	COG0516	GMP reductase activity
N646_2772	COG0517	IMP dehydrogenase activity
N646_2773	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N646_2773	COG0519	Catalyzes the synthesis of GMP from XMP
N646_2774	COG1757	Na H antiporter
N646_2776	COG1584	GPR1 FUN34 yaaH family protein
N646_2777	COG1115	amino acid carrier protein
N646_2780	COG2873	o-acetylhomoserine
N646_2781	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
N646_2785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N646_2785	COG3153	acetyltransferase
N646_2786	COG0583	DNA-binding transcription factor activity
N646_2794	COG0328	RNA-DNA hybrid ribonuclease activity
N646_2796	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
N646_2797	COG2867	negative regulation of translational initiation
N646_2798	COG2914	Belongs to the UPF0125 (RnfH) family
N646_2799	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N646_2801	COG0497	DNA recombination
N646_2803	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N646_2804	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
N646_2805	COG1301	dicarboxylic acid transport
N646_2807	COG0484	heat shock protein binding
N646_2813	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
N646_2814	COG0590	tRNA wobble adenosine to inosine editing
N646_2816	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
N646_2817	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N646_2817	COG0047	phosphoribosylformylglycinamidine synthase activity
N646_2824	COG2195	Cleaves the N-terminal amino acid of tripeptides
N646_2825	COG2252	PERMEase
N646_2826	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
N646_2829	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
N646_2830	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
N646_2831	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N646_2832	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N646_2832	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N646_2837	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
N646_2838	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
N646_2839	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N646_2840	COG0142	geranyltranstransferase activity
N646_2841	COG1722	exodeoxyribonuclease VII activity
N646_2842	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
N646_2844	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N646_2844	COG0301	tRNA thio-modification
N646_2845	COG0583	DNA-binding transcription factor activity
N646_2847	COG2363	Small membrane protein
N646_2851	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N646_2852	COG1611	Belongs to the LOG family
N646_2855	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
N646_2855	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
N646_2858	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
N646_2859	COG1464	Belongs to the NlpA lipoprotein family
N646_2860	COG2011	ABC-type metal ion transport system permease component
N646_2861	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N646_2862	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
N646_2864	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N646_2864	COG1263	PTS System
N646_2865	COG0366	Alpha amylase catalytic
N646_2868	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
N646_2869	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N646_2870	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
N646_2871	COG0321	lipoyl(octanoyl) transferase activity
N646_2873	COG1686	Belongs to the peptidase S11 family
N646_2874	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
N646_2875	COG0772	Belongs to the SEDS family
N646_2876	COG0768	penicillin binding
N646_2877	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
N646_2878	COG0799	negative regulation of ribosome biogenesis
N646_2879	COG1466	dna polymerase III delta subunit
N646_2880	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
N646_2881	COG0495	leucyl-tRNA aminoacylation
N646_2882	COG2888	peptidyl-tyrosine sulfation
N646_2883	COG0815	Transfers the fatty acyl group on membrane lipoproteins
N646_2884	COG4535	Mg2 and Co2 transporter CorC
N646_2885	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
N646_2886	COG1702	phosphate starvation-inducible protein PhoH
N646_2887	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N646_2888	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N646_2889	COG0012	GTP binding
N646_2890	COG0193	aminoacyl-tRNA hydrolase activity
N646_2891	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N646_2892	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
N646_2893	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
N646_2894	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
N646_2896	COG2890	protein-(glutamine-N5) methyltransferase activity
N646_2897	COG3094	Invasion gene expression up-regulator, SirB
N646_2898	COG2912	Transglutaminase-like superfamily
N646_2899	COG2877	3-deoxy-8-phosphooctulonate synthase activity
N646_2900	COG0737	Belongs to the 5'-nucleotidase family
N646_2901	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
N646_2902	COG1187	pseudouridine synthase activity
N646_2903	COG2840	Smr protein MutS2
N646_2909	COG2608	mercury ion transmembrane transporter activity
N646_2909	COG2217	Heavy metal translocating P-type atpase
N646_2911	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
N646_2922	COG0835	chemotaxis
N646_2922	COG0784	Response regulator, receiver
N646_2923	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
N646_2924	COG1815	bacterial-type flagellum-dependent cell motility
N646_2925	COG1558	bacterial-type flagellum-dependent cell motility
N646_2926	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
N646_2927	COG1749	Flagellar hook protein flgE
N646_2929	COG4787	bacterial-type flagellum-dependent cell motility
N646_2930	COG4786	Flagellar basal body rod
N646_2931	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
N646_2932	COG1706	bacterial-type flagellum-dependent cell motility
N646_2933	COG1705	Flagellar rod assembly protein muramidase FlgJ
N646_2933	COG3951	Flagellar rod assembly protein muramidase FlgJ
N646_2935	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N646_2936	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N646_2937	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N646_2938	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N646_2939	COG2190	(PTS) system
N646_2940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N646_2941	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N646_2942	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N646_2943	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
N646_2944	COG3115	cell septum assembly
N646_2945	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N646_2949	COG0330	HflC and HflK could
N646_2950	COG2194	sulfuric ester hydrolase activity
N646_2954	COG1192	Involved in chromosome partitioning
N646_2956	COG1215	transferase activity, transferring glycosyl groups
N646_2957	COG1215	transferase activity, transferring glycosyl groups
N646_2958	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
N646_2960	COG3118	belongs to the thioredoxin family
N646_2961	COG0300	oxidoreductase activity
N646_2962	COG1090	epimerase
N646_2967	COG0622	Phosphoesterase
N646_2971	COG3710	Transcriptional regulator
N646_2972	COG0326	Molecular chaperone. Has ATPase activity
N646_2975	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
N646_2976	COG3104	oligopeptide transport
N646_2977	COG0250	Participates in transcription elongation, termination and antitermination
N646_2978	COG0367	asparagine synthase
N646_2980	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N646_2980	COG4651	solute:proton antiporter activity
N646_2981	COG1940	carbohydrate kinase activity
N646_2981	COG1846	Transcriptional regulator
N646_2982	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
N646_2983	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N646_2983	COG2190	(PTS) system
N646_2983	COG1263	PTS System
N646_2984	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N646_2985	COG0735	belongs to the Fur family
N646_2987	COG0716	FMN binding
N646_2989	COG0596	Alpha beta hydrolase
N646_2990	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
N646_2991	COG0033	Phosphoglucomutase
N646_2993	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N646_2995	COG2009	succinate dehydrogenase
N646_2996	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
N646_2997	COG1053	succinate dehydrogenase
N646_2998	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N646_2999	COG0567	Dehydrogenase, E1 component
N646_3000	COG0508	dehydrogenase complex catalyzes the overall conversion of
N646_3001	COG0045	succinate-CoA ligase (ADP-forming) activity
N646_3003	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N646_3004	COG1121	(ABC) transporter
N646_3005	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
N646_3006	COG4977	sequence-specific DNA binding
N646_3007	COG1918	ferrous iron import across plasma membrane
N646_3012	COG0018	arginyl-trna synthetase
N646_3013	COG3102	Protein conserved in bacteria
N646_3016	COG0788	formyltetrahydrofolate deformylase activity
N646_3018	COG1199	ATP-dependent helicase activity
N646_3019	COG1214	PFAM Peptidase M22, glycoprotease
N646_3021	COG3065	identical protein binding
N646_3022	COG2267	carboxylic ester hydrolase activity
N646_3023	COG0318	PFAM AMP-dependent synthetase and ligase
N646_3024	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
N646_3026	COG2894	cell division
N646_3027	COG0850	regulation of cytokinetic process
N646_3028	COG3100	YcgL domain-containing protein
N646_3029	COG2951	lytic endotransglycosylase activity
N646_3031	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
N646_3032	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
N646_3034	COG1028	Short-chain dehydrogenase reductase Sdr
N646_3035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N646_3036	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N646_3041	COG2986	histidine ammonia-lyase
N646_3042	COG1216	Glycosyl transferase, family 2
N646_3043	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N646_3046	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N646_3047	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N646_3054	COG0513	Belongs to the DEAD box helicase family
N646_3055	COG0569	domain protein
N646_3056	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N646_3059	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
N646_3060	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
N646_3061	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
N646_3062	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
N646_3066	COG0544	peptidyl-prolyl cis-trans isomerase activity
N646_3068	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
N646_3069	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
N646_3070	COG0776	regulation of translation
N646_3071	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N646_3072	COG1555	photosystem II stabilization
N646_3075	COG0232	Belongs to the dGTPase family. Type 2 subfamily
N646_3076	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
N646_3077	COG0436	Aminotransferase
N646_3078	COG0784	Response regulator, receiver
N646_3078	COG0835	chemotaxis
N646_3080	COG0748	coenzyme F420 binding
N646_3081	COG3721	Heme iron utilization protein
N646_3083	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
N646_3084	COG0811	peptide transport
N646_3085	COG0848	biopolymer transport protein
N646_3087	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N646_3088	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
N646_3096	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
N646_3098	COG0633	Ferredoxin
N646_3098	COG3217	Mosc domain protein beta barrel domain protein
N646_3098	COG0633	Ferredoxin
N646_3098	COG3217	Mosc domain protein beta barrel domain protein
N646_3099	COG0401	homolog of Blt101
N646_3100	COG0418	dihydroorotase activity
N646_3101	COG2354	Protein conserved in bacteria
N646_3104	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N646_3105	COG4605	iron ion homeostasis
N646_3106	COG4607	ABC-type enterochelin transport system periplasmic component
N646_3107	COG4774	siderophore transport
N646_3108	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
N646_3114	COG3833	ABC-type maltose transport systems, permease component
N646_3115	COG1175	transmembrane transport
N646_3117	COG3842	ATPase activity
N646_3118	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N646_3121	COG3206	protein involved in exopolysaccharide biosynthesis
N646_3121	COG0489	protein tyrosine kinase activity
N646_3131	COG1309	transcriptional regulator
N646_3132	COG2130	NADP-dependent
N646_3134	COG0753	catalase activity
N646_3135	COG2084	Dehydrogenase
N646_3141	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N646_3142	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
N646_3144	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N646_3145	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N646_3151	COG0583	DNA-binding transcription factor activity
N646_3152	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N646_3153	COG0569	domain protein
N646_3156	COG1132	(ABC) transporter
N646_3157	COG4774	siderophore transport
N646_3158	COG1120	ATPase activity
N646_3159	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
N646_3166	COG2197	response regulator
N646_3169	COG0714	Associated with various cellular activities
N646_3173	COG2304	oxidoreductase activity
N646_3177	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N646_3178	COG0581	inorganic phosphate transmembrane transporter activity
N646_3179	COG0573	inorganic phosphate transmembrane transporter activity
N646_3180	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N646_3185	COG4771	TonB-dependent receptor
N646_3186	COG1770	oligopeptidase
N646_3187	COG0513	Belongs to the DEAD box helicase family
N646_3189	COG1388	LysM domain
N646_3189	COG1376	ErfK ybiS ycfS ynhG family protein
N646_3190	COG0415	Belongs to the DNA photolyase family
N646_3191	COG0789	Transcriptional regulator
N646_3192	COG3272	Protein of unknown function (DUF1722)
N646_3193	COG0813	purine-nucleoside phosphorylase activity
N646_3196	COG3706	GGDEF domain
N646_3198	COG1566	PFAM secretion protein HlyD family protein
N646_3199	COG4720	Psort location CytoplasmicMembrane, score
N646_3200	COG1122	ATPase activity
N646_3201	COG1122	ATPase activity
N646_3205	COG0348	domain, Protein
N646_3206	COG0437	4 iron, 4 sulfur cluster binding
N646_3207	COG1247	-acetyltransferase
N646_3211	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
N646_3213	COG1067	ATP-dependent peptidase activity
N646_3215	COG4172	Belongs to the ABC transporter superfamily
N646_3216	COG1505	serine-type exopeptidase activity
N646_3217	COG0583	DNA-binding transcription factor activity
N646_3218	COG1620	l-lactate permease
N646_3219	COG1304	FMN binding
N646_3221	COG0668	transmembrane transport
N646_3228	COG1063	alcohol dehydrogenase
N646_3229	COG0156	8-amino-7-oxononanoate synthase activity
N646_3230	COG5001	Diguanylate cyclase
N646_3230	COG3300	MHYT domain
N646_3235	COG0745	RESPONSE REGULATOR receiver
N646_3240	COG0346	lactoylglutathione lyase activity
N646_3253	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N646_3256	COG2204	response regulator
N646_3261	COG1987	bacterial-type flagellum assembly
N646_3263	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
N646_3266	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N646_3267	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
N646_3268	COG1516	flagellar protein fliS
N646_3271	COG1580	Controls the rotational direction of flagella during chemotaxis
N646_3272	COG1191	sigma factor activity
N646_3273	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
N646_3274	COG1360	Flagellar Motor Protein
N646_3281	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
N646_3282	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
N646_3286	COG2205	protein histidine kinase activity
N646_3287	COG0745	RESPONSE REGULATOR receiver
N646_3289	COG0454	-acetyltransferase
N646_3291	COG2814	Major facilitator Superfamily
N646_3300	COG0628	permease
N646_3301	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
N646_3305	COG4628	conserved protein (DUF2132)
N646_3306	COG0583	DNA-binding transcription factor activity
N646_3312	COG1686	Belongs to the peptidase S11 family
N646_3316	COG0415	Belongs to the DNA photolyase family
N646_3317	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
N646_3318	COG3397	chitin binding
N646_3319	COG4667	esterase of the alpha-beta hydrolase superfamily
N646_3320	COG2095	MarC family integral membrane protein
N646_3329	COG0583	DNA-binding transcription factor activity
N646_3331	COG1301	dicarboxylic acid transport
N646_3332	COG3339	Conserved Protein
N646_3334	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N646_3335	COG0700	Nucleoside recognition
N646_3336	COG3366	ferrous iron transmembrane transporter activity
N646_3339	COG0366	Alpha amylase catalytic
N646_3340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N646_3341	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
N646_3342	COG1640	4-alpha-glucanotransferase
N646_3343	COG0058	SHG alpha-glucan phosphorylase activity
N646_3344	COG2909	trisaccharide binding
N646_3347	COG1999	signal sequence binding
N646_3348	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N646_3348	COG1263	PTS System
N646_3349	COG1162	GTPase activity
N646_3350	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
N646_3351	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
N646_3355	COG2356	endonuclease I
N646_3359	COG4580	involved in the transport of maltose and maltodextrins
N646_3361	COG1760	l-serine dehydratase
N646_3371	COG1609	Transcriptional regulator
N646_3372	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
N646_3377	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N646_3378	COG1609	Transcriptional regulator
N646_3380	COG2814	Major facilitator Superfamily
N646_3383	COG0739	heme binding
N646_3385	COG0612	Peptidase, M16
N646_3386	COG0840	transmembrane signaling receptor activity
N646_3387	COG1120	ATPase activity
N646_3388	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N646_3389	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N646_3390	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
N646_3391	COG4772	TonB-dependent receptor
N646_3396	COG4264	IucA IucC family
N646_3397	COG0019	diaminopimelate decarboxylase activity
N646_3401	COG1136	(ABC) transporter
N646_3409	COG1764	response to oxidative stress
N646_3410	COG1846	Transcriptional regulator
N646_3412	COG0450	alkyl hydroperoxide reductase
N646_3413	COG3634	alkyl hydroperoxide reductase activity
N646_3422	COG2258	MOSC domain
N646_3423	COG0513	Belongs to the DEAD box helicase family
N646_3426	COG1132	(ABC) transporter
N646_3435	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N646_3440	COG0259	pyridoxamine-phosphate oxidase activity
N646_3452	COG4166	transmembrane transport
N646_3455	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
N646_3456	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N646_3456	COG1263	PTS System
N646_3457	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
N646_3458	COG3340	Belongs to the peptidase S51 family
N646_3462	COG1444	tRNA N-acetyltransferase activity
N646_3467	COG4608	Belongs to the ABC transporter superfamily
N646_3468	COG0444	Belongs to the ABC transporter superfamily
N646_3470	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
N646_3470	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N646_3475	COG0772	Belongs to the SEDS family
N646_3481	COG3275	phosphorelay sensor kinase activity
N646_3482	COG3279	Response regulator of the LytR AlgR family
N646_3483	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
N646_3487	COG0786	glutamate:sodium symporter activity
N646_3489	COG1131	(ABC) transporter
N646_3491	COG0786	glutamate:sodium symporter activity
N646_3493	COG0363	glucosamine-6-phosphate deaminase activity
N646_3497	COG1741	Belongs to the pirin family
N646_3498	COG2259	Doxx family
N646_3500	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N646_3500	COG2169	Transcriptional regulator
N646_3501	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N646_3503	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
N646_3509	COG0596	Alpha beta hydrolase
N646_3512	COG3123	guanosine phosphorylase activity
N646_3514	COG5001	Diguanylate cyclase
N646_3515	COG0534	Mate efflux family protein
N646_3516	COG0564	pseudouridine synthase activity
N646_3519	COG0583	DNA-binding transcription factor activity
N646_3520	COG0561	phosphatase activity
N646_3522	COG2199	diguanylate cyclase activity
N646_3525	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
N646_3526	COG2162	N-hydroxyarylamine O-acetyltransferase activity
N646_3527	COG0583	DNA-binding transcription factor activity
N646_3528	COG2375	cellular response to nickel ion
N646_3534	COG1357	PFAM Pentapeptide repeats (8 copies)
N646_3536	COG3047	cAMP biosynthetic process
N646_3548	COG3835	regulator
N646_3549	COG2610	gluconate transmembrane transporter activity
N646_3550	COG1929	Belongs to the glycerate kinase type-1 family
N646_3551	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N646_3555	COG0456	acetyltransferase
N646_3558	COG1028	Short-chain dehydrogenase reductase Sdr
N646_3559	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N646_3560	COG3005	denitrification pathway
N646_3561	COG0243	molybdopterin cofactor binding
N646_3563	COG0352	thiamine-phosphate diphosphorylase activity
N646_3564	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
N646_3565	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
N646_3566	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N646_3567	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N646_3568	COG1116	anion transmembrane transporter activity
N646_3569	COG0351	phosphomethylpyrimidine kinase
N646_3570	COG0312	modulator of DNA gyrase
N646_3571	COG0312	modulator of DNA gyrase
N646_3572	COG1901	pseudouridine methyltransferase
N646_3579	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N646_3581	COG0584	glycerophosphoryl diester phosphodiesterase
N646_3582	COG0745	RESPONSE REGULATOR receiver
N646_3586	COG0811	peptide transport
N646_3587	COG0811	peptide transport
N646_3588	COG0848	biopolymer transport protein
N646_3596	COG0803	Belongs to the bacterial solute-binding protein 9 family
N646_3597	COG1121	(ABC) transporter
N646_3598	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N646_3601	COG1770	oligopeptidase
N646_3602	COG2814	Major facilitator Superfamily
N646_3603	COG0010	Belongs to the arginase family
N646_3604	COG1166	arginine decarboxylase activity
N646_3606	COG0189	ligase activity
N646_3606	COG4067	protein conserved in archaea
N646_3607	COG0189	ligase activity
N646_3611	COG0583	DNA-binding transcription factor activity
N646_3615	COG4191	Histidine kinase
N646_3618	COG3706	GGDEF domain
N646_3623	COG0579	oxidoreductase
N646_3626	COG1294	oxidase, subunit
N646_3627	COG1271	oxidase subunit
N646_3629	COG3033	Beta-eliminating lyase
N646_3632	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
N646_3635	COG3706	GGDEF domain
N646_3638	COG3706	GGDEF domain
N646_3639	COG0415	Belongs to the DNA photolyase family
N646_3640	COG3046	protein related to deoxyribodipyrimidine photolyase
N646_3642	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N646_3642	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N646_3643	COG1765	OsmC-like protein
N646_3644	COG0110	maltose O-acetyltransferase activity
N646_3652	COG1011	Hydrolase
N646_3655	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
N646_3657	COG2067	long-chain fatty acid transport protein
N646_3659	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N646_3660	COG1136	(ABC) transporter
N646_3660	COG0577	efflux transmembrane transporter activity
N646_3663	COG1309	transcriptional regulator
N646_3664	COG3240	lipase activity
N646_3670	COG1840	ABC-type Fe3 transport system, periplasmic component
N646_3671	COG3842	ATPase activity
N646_3676	COG2990	Protein conserved in bacteria
N646_3679	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N646_3680	COG2866	Carboxypeptidase
N646_3683	COG0583	DNA-binding transcription factor activity
N646_3686	COG1760	l-serine dehydratase
N646_3690	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
N646_3691	COG0741	lytic transglycosylase activity
N646_3691	COG1388	LysM domain
N646_3695	COG1815	bacterial-type flagellum-dependent cell motility
N646_3696	COG1558	bacterial-type flagellum-dependent cell motility
N646_3697	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
N646_3698	COG1749	Flagellar hook protein flgE
N646_3699	COG4787	bacterial-type flagellum-dependent cell motility
N646_3700	COG4786	Flagellar basal body rod
N646_3701	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
N646_3702	COG1706	bacterial-type flagellum-dependent cell motility
N646_3704	COG4786	Flagellar basal body rod
N646_3704	COG1256	bacterial-type flagellum assembly
N646_3709	COG1304	FMN binding
N646_3713	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N646_3714	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
N646_3715	COG0459	protein refolding
N646_3717	COG1280	lysine exporter protein (LysE YggA)
N646_3721	COG1309	transcriptional regulator
N646_3725	COG4302	ethanolamine ammonia-lyase activity
N646_3726	COG0531	amino acid
N646_3727	COG2070	2-Nitropropane dioxygenase
N646_3729	COG1349	DNA-binding transcription factor activity
N646_3732	COG1335	isochorismatase
N646_3735	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
N646_3740	COG0583	DNA-binding transcription factor activity
N646_3744	COG3713	MltA-interacting MipA family protein
N646_3745	COG3015	lipoprotein NlpE involved in copper resistance
N646_3746	COG3448	diguanylate cyclase activity
N646_3746	COG4175	Glycine betaine
N646_3747	COG4176	ABC-type proline glycine betaine transport system permease component
N646_3749	COG1342	Belongs to the UPF0251 family
N646_3754	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N646_3755	COG4948	Mandelate Racemase Muconate Lactonizing
N646_3757	COG0583	DNA-binding transcription factor activity
N646_3763	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N646_3764	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N646_3766	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N646_3770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N646_3774	COG3842	ATPase activity
N646_3780	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N646_3784	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
N646_3785	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N646_3786	COG2197	response regulator
N646_3789	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
N646_3790	COG0252	asparaginase activity
N646_3792	COG0583	DNA-binding transcription factor activity
N646_3795	COG3122	Protein conserved in bacteria
N646_3797	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
N646_3798	COG1012	belongs to the aldehyde dehydrogenase family
N646_3799	COG1522	sequence-specific DNA binding
N646_3800	COG3608	succinylglutamate desuccinylase aspartoacylase
N646_3801	COG0006	proline dipeptidase activity
N646_3802	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N646_3804	COG1028	Short-chain dehydrogenase reductase Sdr
N646_3807	COG1902	pentaerythritol trinitrate reductase activity
N646_3810	COG0583	DNA-binding transcription factor activity
N646_3812	COG0513	Belongs to the DEAD box helicase family
N646_3817	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N646_3818	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
N646_3818	COG2207	Transcriptional regulator
N646_3819	COG0583	DNA-binding transcription factor activity
N646_3820	COG0300	oxidoreductase activity
N646_3823	COG3746	phosphate-selective porin O and P
N646_3826	COG1028	Short-chain dehydrogenase reductase Sdr
N646_3827	COG1404	Belongs to the peptidase S8 family
N646_3828	COG0583	DNA-binding transcription factor activity
N646_3829	COG4771	TonB-dependent receptor
N646_3833	COG1263	PTS System
N646_3833	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N646_3834	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N646_3835	COG1621	beta-fructofuranosidase activity
N646_3836	COG0625	glutathione transferase activity
N646_3837	COG1686	Belongs to the peptidase S11 family
N646_3839	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N646_3839	COG0678	peroxiredoxin activity
N646_3840	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N646_3843	COG1278	Cold shock
N646_3844	COG1741	Belongs to the pirin family
N646_3845	COG4667	esterase of the alpha-beta hydrolase superfamily
N646_3848	COG2194	sulfuric ester hydrolase activity
N646_3849	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
N646_3851	COG2205	protein histidine kinase activity
N646_3852	COG0745	RESPONSE REGULATOR receiver
N646_3855	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N646_3859	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N646_3861	COG2814	Major facilitator Superfamily
N646_3863	COG1418	mRNA catabolic process
N646_3864	COG0402	S-adenosylhomocysteine deaminase activity
N646_3865	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
N646_3867	COG2239	Acts as a magnesium transporter
N646_3868	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N646_3869	COG1566	PFAM secretion protein HlyD family protein
N646_3875	COG0745	RESPONSE REGULATOR receiver
N646_3876	COG2205	protein histidine kinase activity
N646_3879	COG0531	amino acid
N646_3881	COG0583	DNA-binding transcription factor activity
N646_3886	COG5002	protein histidine kinase activity
N646_3886	COG0784	Response regulator, receiver
N646_3886	COG2205	protein histidine kinase activity
N646_3887	COG0534	Mate efflux family protein
N646_3890	COG3132	Protein of unknown function, DUF480
N646_3891	COG2827	Endonuclease containing a URI domain
N646_3892	COG1879	ABC-type sugar transport system periplasmic component
N646_3893	COG2205	protein histidine kinase activity
N646_3893	COG0784	Response regulator, receiver
N646_3894	COG1846	Transcriptional regulator
N646_3904	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N646_3905	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N646_3907	COG1280	lysine exporter protein (LysE YggA)
N646_3909	COG0183	Belongs to the thiolase family
N646_3911	COG3243	poly(R)-hydroxyalkanoic acid synthase
N646_3913	COG3005	denitrification pathway
N646_3915	COG0243	molybdopterin cofactor binding
N646_3917	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
N646_3918	COG3850	Histidine kinase
N646_3919	COG2197	response regulator
N646_3922	COG2195	Cleaves the N-terminal amino acid of tripeptides
N646_3926	COG0840	transmembrane signaling receptor activity
N646_3928	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N646_3930	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N646_3931	COG2814	Major facilitator Superfamily
N646_3933	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
N646_3934	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
N646_3938	COG2897	thiosulfate sulfurtransferase activity
N646_3941	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
N646_3945	COG0038	chloride channel
N646_3950	COG4989	oxidoreductase activity
N646_3953	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
N646_3953	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
N646_3955	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
N646_3967	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N646_3970	COG0739	heme binding
N646_3979	COG3501	Rhs element vgr protein
N646_3984	COG0515	serine threonine protein kinase
N646_3991	COG1522	sequence-specific DNA binding
N646_4004	COG2814	Major facilitator Superfamily
N646_4006	COG0583	DNA-binding transcription factor activity
N646_4007	COG4221	oxidoreductase activity
N646_4008	COG0589	response to stress
N646_4010	COG2111	Na H antiporter
N646_4010	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N646_4014	COG2212	antiporter activity
N646_4015	COG1320	monovalent cation:proton antiporter activity
N646_4016	COG2188	Transcriptional regulator
N646_4017	COG1486	melibiose metabolic process
N646_4018	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N646_4018	COG1263	PTS System
N646_4019	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N646_4025	COG1022	Amp-dependent synthetase and ligase
N646_4031	COG0500	methyltransferase
N646_4034	COG3527	Alpha-acetolactate decarboxylase
N646_4036	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N646_4039	COG1294	oxidase, subunit
N646_4040	COG1271	oxidase subunit
N646_4041	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N646_4042	COG0110	maltose O-acetyltransferase activity
N646_4044	COG3264	Mechanosensitive ion channel
N646_4044	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
N646_4047	COG0439	Biotin carboxylase
N646_4049	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N646_4050	COG1960	acyl-CoA dehydrogenase activity
N646_4052	COG0183	Belongs to the thiolase family
N646_4054	COG1960	acyl-CoA dehydrogenase activity
N646_4055	COG1024	Enoyl-CoA hydratase
N646_4058	COG1028	Short-chain dehydrogenase reductase Sdr
N646_4059	COG3706	GGDEF domain
N646_4059	COG0745	RESPONSE REGULATOR receiver
N646_4060	COG1309	transcriptional regulator
N646_4061	COG1012	belongs to the aldehyde dehydrogenase family
N646_4064	COG4176	ABC-type proline glycine betaine transport system permease component
N646_4065	COG0517	IMP dehydrogenase activity
N646_4065	COG4175	Glycine betaine
N646_4070	COG0330	HflC and HflK could
N646_4074	COG2205	protein histidine kinase activity
N646_4074	COG0784	Response regulator, receiver
N646_4076	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N646_4087	COG5001	Diguanylate cyclase
N646_4088	COG1869	D-ribose catabolic process
N646_4089	COG1129	ABC transporter
N646_4090	COG1172	Belongs to the binding-protein-dependent transport system permease family
N646_4091	COG1879	ABC-type sugar transport system periplasmic component
N646_4092	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N646_4093	COG1609	Transcriptional regulator
N646_4096	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
N646_4098	COG4607	ABC-type enterochelin transport system periplasmic component
N646_4099	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N646_4100	COG4605	iron ion homeostasis
N646_4101	COG4604	ABC transporter, ATP-binding protein
N646_4102	COG0789	Transcriptional regulator
N646_4104	COG4771	TonB-dependent receptor
N646_4104	COG1629	transport
N646_4110	COG1289	transmembrane transporter activity
N646_4111	COG0210	DNA helicase
N646_4112	COG1803	Methylglyoxal synthase
N646_4113	COG1879	ABC-type sugar transport system periplasmic component
N646_4114	COG0784	Response regulator, receiver
N646_4114	COG2205	protein histidine kinase activity
N646_4114	COG2198	Histidine kinase
N646_4118	COG0745	RESPONSE REGULATOR receiver
N646_4119	COG3119	arylsulfatase activity
N646_4121	COG3119	arylsulfatase activity
N646_4122	COG0641	radical SAM
N646_4123	COG0714	Associated with various cellular activities
N646_4129	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N646_4130	COG0583	DNA-binding transcription factor activity
N646_4131	COG1597	lipid kinase activity
N646_4132	COG3111	PFAM Bacterial OB fold (BOF) protein
N646_4137	COG3069	C4-dicarboxylate transmembrane transporter activity
N646_4139	COG1214	PFAM Peptidase M22, glycoprotease
N646_4139	COG0456	acetyltransferase
N646_4143	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
N646_4144	COG0784	Response regulator, receiver
N646_4144	COG2205	protein histidine kinase activity
N646_4145	COG5001	Diguanylate cyclase
N646_4145	COG3300	MHYT domain
N646_4146	COG2197	response regulator
N646_4147	COG3706	GGDEF domain
N646_4149	COG2197	response regulator
N646_4150	COG0835	chemotaxis
N646_4150	COG0784	Response regulator, receiver
N646_4153	COG2962	Rard protein
N646_4157	COG2076	Multidrug Resistance protein
N646_4163	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
N646_4163	COG0069	glutamate synthase activity
N646_4164	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
N646_4169	COG1902	pentaerythritol trinitrate reductase activity
N646_4170	COG0346	lactoylglutathione lyase activity
N646_4174	COG2239	Acts as a magnesium transporter
N646_4180	COG0242	peptide deformylase activity
N646_4188	COG2176	DNA-directed DNA polymerase activity
N646_4195	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N646_4196	COG0697	spore germination
N646_4197	COG0583	DNA-binding transcription factor activity
N646_4198	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N646_4199	COG0346	lactoylglutathione lyase activity
N646_4201	COG0509	glycine decarboxylation via glycine cleavage system
N646_4202	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N646_4204	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N646_4210	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
N646_4210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N646_4210	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N646_4211	COG1105	Belongs to the carbohydrate kinase PfkB family
N646_4212	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
N646_4212	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N646_4214	COG1609	Transcriptional regulator
N646_4217	COG2200	EAL domain
N646_4217	COG2199	diguanylate cyclase activity
N646_4217	COG2203	Gaf domain
N646_4218	COG0765	amino acid transport
N646_4219	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N646_4220	COG0765	amino acid transport
N646_4221	COG1126	abc transporter atp-binding protein
N646_4223	COG1979	alcohol dehydrogenase
N646_4224	COG2207	Transcriptional regulator
N646_4226	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
N646_4227	COG2759	Belongs to the formate--tetrahydrofolate ligase family
N646_4228	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N646_4231	COG0546	phosphoglycolate phosphatase activity
N646_4232	COG0840	transmembrane signaling receptor activity
N646_4234	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
N646_4236	COG0513	Belongs to the DEAD box helicase family
N646_4241	COG3038	cytochrome b561
N646_4242	COG2353	YceI-like domain
N646_4243	COG2116	formate transmembrane transporter activity
N646_4244	COG0583	DNA-binding transcription factor activity
N646_4246	COG3593	DNA synthesis involved in DNA repair
N646_4247	COG0737	Belongs to the 5'-nucleotidase family
N646_4252	COG2267	carboxylic ester hydrolase activity
N646_4253	COG2067	long-chain fatty acid transport protein
N646_4256	COG2050	protein possibly involved in aromatic compounds catabolism
N646_4258	COG4533	DNA binding
N646_4266	COG3300	MHYT domain
N646_4266	COG5001	Diguanylate cyclase
N646_4267	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
N646_4269	COG4181	ATPase activity
N646_4270	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
N646_4272	COG1984	allophanate hydrolase subunit 2
N646_4273	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
N646_4274	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
N646_4275	COG3447	MASE1 domain protein
N646_4275	COG5001	Diguanylate cyclase
N646_4275	COG5002	protein histidine kinase activity
N646_4280	COG0583	DNA-binding transcription factor activity
N646_4281	COG1042	CoA-binding domain protein
N646_4281	COG0045	succinate-CoA ligase (ADP-forming) activity
N646_4281	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N646_4283	COG1181	Belongs to the D-alanine--D-alanine ligase family
N646_4285	COG0023	Translation Initiation Factor
N646_4295	COG4128	Pfam Zonular occludens toxin
N646_4299	COG0583	DNA-binding transcription factor activity
N646_4302	COG3140	Belongs to the UPF0181 family
N646_4307	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
N646_4308	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
N646_4311	COG3706	GGDEF domain
N646_4311	COG0745	RESPONSE REGULATOR receiver
N646_4312	COG3706	GGDEF domain
N646_4312	COG5001	Diguanylate cyclase
N646_4312	COG4251	negative regulation of phosphorylation
N646_4312	COG2203	Gaf domain
N646_4314	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
N646_4315	COG4149	molybdate abc transporter
N646_4316	COG0725	ABC transporter, periplasmic molybdate-binding protein
N646_4318	COG3111	PFAM Bacterial OB fold (BOF) protein
N646_4321	COG0189	ligase activity
N646_4321	COG4067	protein conserved in archaea
N646_4324	COG2207	Transcriptional regulator
N646_4325	COG0534	Mate efflux family protein
N646_4326	COG0602	queuosine metabolic process
N646_4327	COG1328	CTP reductase activity
N646_4334	COG1794	racemase activity, acting on amino acids and derivatives
N646_4335	COG0384	phenazine biosynthesis protein PhzF
N646_4338	COG0243	molybdopterin cofactor binding
N646_4339	COG0583	DNA-binding transcription factor activity
N646_4340	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
N646_4342	COG2197	response regulator
N646_4343	COG3851	Histidine kinase
N646_4345	COG2271	Major facilitator Superfamily
N646_4350	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N646_4351	COG3118	belongs to the thioredoxin family
N646_4352	COG2814	Major facilitator Superfamily
N646_4359	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
N646_4363	COG2116	formate transmembrane transporter activity
N646_4364	COG2146	nitrite reductase [NAD(P)H] activity
N646_4365	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N646_4366	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N646_4370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N646_4376	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N646_4379	COG0277	FAD linked oxidase domain protein
N646_4380	COG0583	DNA-binding transcription factor activity
N646_4382	COG2425	protein containing a von Willebrand factor type A (vWA) domain
N646_4385	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
N646_4387	COG1288	antiporter activity
N646_4389	COG3040	lipid binding
N646_4392	COG0419	ATPase involved in DNA repair
N646_4393	COG0420	3'-5' exonuclease activity
N646_4397	COG3501	Rhs element vgr protein
N646_4408	COG0631	protein serine/threonine phosphatase activity
N646_4415	COG2815	serine threonine protein kinase
N646_4415	COG0515	serine threonine protein kinase
N646_4426	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N646_4426	COG2146	nitrite reductase [NAD(P)H] activity
N646_4427	COG1116	anion transmembrane transporter activity
N646_4428	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N646_4429	COG1116	anion transmembrane transporter activity
N646_4429	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N646_4431	COG3707	response regulator
N646_4435	COG0243	molybdopterin cofactor binding
N646_4437	COG0814	amino acid
N646_4438	COG3706	GGDEF domain
N646_4451	COG2847	Copper chaperone PCu(A)C
N646_4452	COG1028	Short-chain dehydrogenase reductase Sdr
N646_4453	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
N646_4456	COG0800	Aldolase
N646_4457	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N646_4458	COG1917	Cupin 2, conserved barrel domain protein
N646_4467	COG2186	Transcriptional regulator
N646_4468	COG2186	Transcriptional regulator
N646_4469	COG0517	IMP dehydrogenase activity
N646_4470	COG2176	DNA-directed DNA polymerase activity
N646_4471	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N646_4485	COG4160	amino acid transport
N646_4486	COG4215	(ABC) transporter
N646_4487	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N646_4488	COG1126	abc transporter atp-binding protein
N646_4494	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N646_4496	COG1012	belongs to the aldehyde dehydrogenase family
N646_4499	COG0446	pyridine nucleotide-disulphide oxidoreductase
N646_4499	COG1902	pentaerythritol trinitrate reductase activity
N646_4500	COG0109	protoheme IX farnesyltransferase activity
N646_4501	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
N646_4502	COG1845	cytochrome c oxidase, subunit III
N646_4503	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N646_4504	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
N646_4505	COG1028	Short-chain dehydrogenase reductase Sdr
N646_4507	COG1024	Enoyl-CoA hydratase
N646_4508	COG1024	Enoyl-CoA hydratase
N646_4511	COG0183	Belongs to the thiolase family
N646_4513	COG1960	acyl-CoA dehydrogenase activity
N646_4514	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N646_4515	COG1024	Enoyl-CoA hydratase
N646_4518	COG0247	lactate metabolic process
N646_4518	COG0277	FAD linked oxidase domain protein
N646_4531	COG2095	MarC family integral membrane protein
N646_4532	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
N646_4534	COG0523	cobalamin synthesis protein
N646_4535	COG0739	heme binding
N646_4536	COG2988	succinylglutamate desuccinylase activity
N646_4537	COG0523	cobalamin synthesis protein
N646_4539	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N646_4540	COG0735	belongs to the Fur family
N646_4543	COG0730	response to heat
N646_4547	COG1073	alpha beta
N646_4548	COG1073	alpha beta
N646_4550	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N646_4553	COG0513	Belongs to the DEAD box helicase family
N646_4554	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
N646_4557	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N646_4560	COG1119	ATPase activity
N646_4561	COG2200	EAL domain
N646_4566	COG0513	Belongs to the DEAD box helicase family
N646_4567	COG0523	cobalamin synthesis protein
N646_4569	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
N646_4571	COG1278	Cold shock
N646_4573	COG0133	tryptophan synthase activity
N646_4575	COG4628	conserved protein (DUF2132)
N646_4576	COG0513	Belongs to the DEAD box helicase family
N646_4579	COG3530	Putative quorum-sensing-regulated virulence factor
N646_4584	COG3186	Phenylalanine-4-hydroxylase
N646_4585	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N646_4586	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N646_4591	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
N646_4592	COG1454	alcohol dehydrogenase
N646_4593	COG2133	pyrroloquinoline quinone binding
N646_4595	COG1943	Transposase
N646_4596	COG0783	Belongs to the Dps family
N646_4597	COG0840	transmembrane signaling receptor activity
N646_4605	COG2205	protein histidine kinase activity
N646_4605	COG0784	Response regulator, receiver
N646_4606	COG1538	Outer membrane efflux protein
N646_4612	COG2199	diguanylate cyclase activity
N646_4614	COG1278	Cold shock
N646_4620	COG0545	Peptidyl-prolyl cis-trans isomerase
N646_4621	COG0109	protoheme IX farnesyltransferase activity
N646_4622	COG1612	heme a metabolic process
N646_4626	COG1845	cytochrome c oxidase, subunit III
N646_4627	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
N646_4629	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
N646_4630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N646_4632	COG1280	lysine exporter protein (LysE YggA)
N646_4636	COG0179	Fumarylacetoacetate (FAA) hydrolase
N646_4639	COG0697	spore germination
N646_4643	COG2814	Major facilitator Superfamily
N646_4644	COG0583	DNA-binding transcription factor activity
N646_4645	COG5001	Diguanylate cyclase
N646_4646	COG0739	heme binding
N646_4653	COG0814	amino acid
N646_4658	COG4989	oxidoreductase activity
N646_4664	COG1733	regulation of RNA biosynthetic process
N646_4665	COG1943	Transposase
N646_4668	COG0798	PFAM Bile acid sodium symporter
N646_4670	COG1881	PFAM PEBP family protein
N646_4673	COG1131	(ABC) transporter
N646_4674	COG0842	Transport permease protein
N646_4676	COG3383	formate dehydrogenase (NAD+) activity
N646_4680	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N646_4685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N646_4687	COG2067	long-chain fatty acid transport protein
N646_4689	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N646_4691	COG1505	serine-type exopeptidase activity
N646_4692	COG0488	(ABC) transporter
N646_4693	COG0589	response to stress
N646_4694	COG2249	NAD(P)H dehydrogenase (quinone) activity
N646_4698	COG0366	Alpha amylase catalytic
N646_4699	COG0789	Transcriptional regulator
N646_4700	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N646_4702	COG4934	collagen metabolic process
N646_4704	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
N646_4705	COG0583	DNA-binding transcription factor activity
N646_4710	COG2610	gluconate transmembrane transporter activity
N646_4711	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N646_4712	COG3622	Belongs to the hyi family
N646_4713	COG0235	Class ii aldolase
N646_4714	COG3395	kinase activity
N646_4715	COG2084	Dehydrogenase
N646_4716	COG1349	DNA-binding transcription factor activity
N646_4718	COG0747	negative chemotaxis
N646_4719	COG4608	Belongs to the ABC transporter superfamily
N646_4720	COG0444	Belongs to the ABC transporter superfamily
N646_4721	COG0534	Mate efflux family protein
N646_4722	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation