locus-tag	class	description
K6754_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K6754_00010	COG0592	DNA-directed DNA polymerase activity
K6754_00020	COG0187	DNA topoisomerase II activity
K6754_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
K6754_00035	COG3977	Valine--pyruvate aminotransferase
K6754_00040	COG0366	Alpha amylase catalytic
K6754_00055	COG2119	membrane
K6754_00065	COG0425	Belongs to the sulfur carrier protein TusA family
K6754_00080	COG0604	alcohol dehydrogenase
K6754_00085	COG0183	Belongs to the thiolase family
K6754_00095	COG1739	Uncharacterized protein family UPF0029
K6754_00100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6754_00220	COG2132	Multicopper oxidase
K6754_00240	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K6754_00245	COG2104	thiamine diphosphate biosynthetic process
K6754_00260	COG0006	proline dipeptidase activity
K6754_00260	COG0006	proline dipeptidase activity
K6754_00290	COG3220	belongs to the UPF0276 family
K6754_00300	COG0210	DNA helicase
K6754_00305	COG0405	Gamma-glutamyltransferase
K6754_00310	COG1280	lysine exporter protein (LysE YggA)
K6754_00320	COG2962	Rard protein
K6754_00325	COG0514	ATP-dependent DNA helicase (RecQ)
K6754_00335	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K6754_00345	COG0248	Ppx GppA phosphatase
K6754_00350	COG0513	Belongs to the DEAD box helicase family
K6754_00355	COG3118	belongs to the thioredoxin family
K6754_00370	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K6754_00375	COG0633	Ferredoxin
K6754_00415	COG3071	HemY protein
K6754_00420	COG2959	enzyme of heme biosynthesis
K6754_00425	COG1587	Uroporphyrinogen-III synthase
K6754_00430	COG0181	hydroxymethylbilane synthase activity
K6754_00435	COG3072	Adenylate cyclase
K6754_00440	COG1965	Belongs to the frataxin family
K6754_00450	COG0019	diaminopimelate decarboxylase activity
K6754_00465	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K6754_00470	COG1011	Hydrolase
K6754_00475	COG2199	diguanylate cyclase activity
K6754_00475	COG2200	EAL domain
K6754_00475	COG3287	FIST C domain
K6754_00480	COG3148	PFAM DTW domain containing protein
K6754_00495	COG0561	phosphatase activity
K6754_00500	COG2267	carboxylic ester hydrolase activity
K6754_00505	COG1280	lysine exporter protein (LysE YggA)
K6754_00510	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K6754_00515	COG0640	Transcriptional regulator
K6754_00520	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K6754_00560	COG2095	MarC family integral membrane protein
K6754_00570	COG0742	ribosomal rna small subunit methyltransferase
K6754_00575	COG0552	protein localization to endoplasmic reticulum
K6754_00580	COG2884	Cell division ATP-binding protein ftsE
K6754_00585	COG2177	Part of the ABC transporter FtsEX involved in
K6754_00595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6754_00600	COG0705	Rhomboid family
K6754_00605	COG1580	Controls the rotational direction of flagella during chemotaxis
K6754_00610	COG3161	chorismate lyase activity
K6754_00615	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K6754_00620	COG2937	Belongs to the GPAT DAPAT family
K6754_00625	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K6754_00630	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K6754_00635	COG0534	Mate efflux family protein
K6754_00640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6754_00660	COG4206	TonB-dependent receptor
K6754_00725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6754_00735	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K6754_00740	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K6754_00740	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K6754_00770	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K6754_00775	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K6754_00780	COG0250	Participates in transcription elongation, termination and antitermination
K6754_00795	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K6754_00800	COG0222	ribosome binding
K6754_00805	COG0085	RNA polymerase activity
K6754_00810	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K6754_00815	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
K6754_00820	COG2816	NAD+ diphosphatase activity
K6754_00825	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K6754_00830	COG1573	uracil-dna glycosylase
K6754_00840	COG3068	Protein conserved in bacteria
K6754_00845	COG1253	flavin adenine dinucleotide binding
K6754_00860	COG0151	Belongs to the GarS family
K6754_00870	COG0789	Transcriptional regulator
K6754_00875	COG3710	Transcriptional regulator
K6754_00880	COG0531	amino acid
K6754_00885	COG1982	Orn Lys Arg decarboxylase major
K6754_00945	COG0488	(ABC) transporter
K6754_00955	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K6754_00960	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6754_00965	COG2264	protein methyltransferase activity
K6754_00970	COG0439	Biotin carboxylase
K6754_00975	COG0511	ligase activity, forming carbon-carbon bonds
K6754_00980	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K6754_00985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6754_01000	COG2814	Major facilitator Superfamily
K6754_01025	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6754_01035	COG3263	regulation of cellular component size
K6754_01045	COG4232	protein-disulfide reductase activity
K6754_01050	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K6754_01055	COG1027	Aspartate ammonia-lyase
K6754_01060	COG3030	protein affecting phage T7 exclusion by the F plasmid
K6754_01065	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K6754_01075	COG2205	protein histidine kinase activity
K6754_01080	COG0745	RESPONSE REGULATOR receiver
K6754_01085	COG3678	ATP-independent chaperone mediated protein folding
K6754_01095	COG0205	6-phosphofructokinase activity
K6754_01100	COG0534	Mate efflux family protein
K6754_01110	COG0459	protein refolding
K6754_01120	COG1285	pathogenesis
K6754_01125	COG1509	lysine 2,3-aminomutase activity
K6754_01140	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K6754_01145	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K6754_01150	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K6754_01155	COG1053	succinate dehydrogenase
K6754_01160	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K6754_01180	COG4942	peptidase
K6754_01185	COG1045	serine acetyltransferase
K6754_01190	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K6754_01195	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K6754_01200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6754_01205	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K6754_01215	COG0471	metal ion transport
K6754_01220	COG0688	phosphatidylethanolamine metabolic process
K6754_01225	COG1162	GTPase activity
K6754_01230	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K6754_01295	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K6754_01300	COG0802	atpase or kinase
K6754_01310	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K6754_01315	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K6754_01325	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K6754_01330	COG0330	HflC and HflK could
K6754_01335	COG0330	HflC and HflK could
K6754_01340	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
K6754_01345	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K6754_01350	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
K6754_01355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K6754_01355	COG1017	nitric oxide dioxygenase activity
K6754_01360	COG1959	2 iron, 2 sulfur cluster binding
K6754_01365	COG0557	exoribonuclease II activity
K6754_01370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6754_01375	COG0546	phosphoglycolate phosphatase activity
K6754_01380	COG0180	Tryptophanyl-tRNA synthetase
K6754_01395	COG0512	Glutamine amidotransferase of anthranilate synthase
K6754_01400	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K6754_01420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6754_01425	COG3954	Phosphoribulokinase
K6754_01435	COG0429	hydrolase of the alpha beta-hydrolase fold
K6754_01445	COG0488	(ABC) transporter
K6754_01450	COG2249	NAD(P)H dehydrogenase (quinone) activity
K6754_01465	COG1047	Peptidyl-prolyl cis-trans
K6754_01470	COG1446	asparaginase
K6754_01485	COG0545	Peptidyl-prolyl cis-trans isomerase
K6754_01490	COG2964	Protein conserved in bacteria
K6754_01495	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
K6754_01500	COG2923	Belongs to the DsrF TusC family
K6754_01520	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K6754_01525	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K6754_01540	COG0281	malic enzyme
K6754_01545	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
K6754_01550	COG0626	cystathionine gamma-synthase activity
K6754_01555	COG0527	aspartate kinase activity
K6754_01555	COG0460	homoserine dehydrogenase
K6754_01560	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K6754_01570	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K6754_01580	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K6754_01590	COG0137	argininosuccinate synthase activity
K6754_01595	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K6754_01595	COG0165	Argininosuccinate lyase
K6754_01610	COG0678	peroxiredoxin activity
K6754_01610	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K6754_01620	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K6754_01650	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K6754_01655	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K6754_01665	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K6754_01670	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K6754_01675	COG0360	Binds together with S18 to 16S ribosomal RNA
K6754_01680	COG2965	DNA replication, synthesis of RNA primer
K6754_01705	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K6754_01710	COG0432	Pfam Uncharacterised protein family UPF0047
K6754_01715	COG0166	Belongs to the GPI family
K6754_01725	COG0735	belongs to the Fur family
K6754_01730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6754_01750	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K6754_01755	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6754_01760	COG0175	sulfate reduction
K6754_01820	COG1410	methionine synthase
K6754_01820	COG0646	methionine synthase
K6754_01825	COG0527	aspartate kinase activity
K6754_01830	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K6754_01840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K6754_01855	COG0629	single-stranded DNA binding
K6754_01860	COG2200	EAL domain
K6754_01860	COG2199	diguanylate cyclase activity
K6754_01880	COG1450	Type ii and iii secretion system protein
K6754_01885	COG3267	Type II secretory pathway component ExeA
K6754_01885	COG3409	Peptidoglycan-binding domain 1 protein
K6754_01895	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K6754_01900	COG1459	type II secretion system
K6754_01910	COG2165	general secretion pathway protein
K6754_01945	COG1077	Cell shape determining protein MreB Mrl
K6754_01950	COG1792	Involved in formation and maintenance of cell shape
K6754_01955	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K6754_01960	COG0424	maF-like protein
K6754_01970	COG3164	Protein of unknown function
K6754_01975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6754_01980	COG0312	modulator of DNA gyrase
K6754_01985	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K6754_01990	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K6754_02000	COG0564	pseudouridine synthase activity
K6754_02005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6754_02010	COG3028	Belongs to the UPF0307 family
K6754_02015	COG0312	modulator of DNA gyrase
K6754_02020	COG2239	Acts as a magnesium transporter
K6754_02025	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6754_02030	COG1660	Displays ATPase and GTPase activities
K6754_02035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6754_02040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K6754_02050	COG1137	ATPase activity
K6754_02055	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K6754_02065	COG0517	IMP dehydrogenase activity
K6754_02065	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K6754_02075	COG1127	ABC transporter
K6754_02080	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K6754_02085	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K6754_02090	COG2854	intermembrane phospholipid transfer
K6754_02100	COG5007	Belongs to the BolA IbaG family
K6754_02105	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K6754_02110	COG0204	Acyl-transferase
K6754_02115	COG0251	oxidation-reduction process
K6754_02120	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K6754_02125	COG0540	Belongs to the ATCase OTCase family
K6754_02155	COG0456	acetyltransferase
K6754_02165	COG0525	valine-tRNA ligase activity
K6754_02170	COG2927	DNA polymerase III (CHI subunit)
K6754_02175	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K6754_02180	COG0795	lipopolysaccharide-transporting ATPase activity
K6754_02185	COG0795	lipopolysaccharide-transporting ATPase activity
K6754_02200	COG1028	Short-chain dehydrogenase reductase Sdr
K6754_02210	COG0726	polysaccharide deacetylase
K6754_02215	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K6754_02220	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K6754_02225	COG1447	Phosphotransferase system cellobiose-specific component IIA
K6754_02230	COG1486	melibiose metabolic process
K6754_02235	COG3394	polysaccharide catabolic process
K6754_02245	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K6754_02320	COG0840	transmembrane signaling receptor activity
K6754_02365	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
K6754_02375	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K6754_02385	COG2066	Belongs to the glutaminase family
K6754_02390	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K6754_02395	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K6754_02405	COG1872	DUF167
K6754_02410	COG0762	integral membrane protein
K6754_02415	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K6754_02420	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K6754_02435	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K6754_02440	COG1678	Uncharacterized ACR, COG1678
K6754_02445	COG0189	ligase activity
K6754_02450	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K6754_02455	COG2356	endonuclease I
K6754_02470	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K6754_02475	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K6754_02480	COG0583	DNA-binding transcription factor activity
K6754_02485	COG4771	TonB-dependent receptor
K6754_02500	COG0191	fructose-bisphosphate aldolase activity
K6754_02505	COG0668	transmembrane transport
K6754_02520	COG0583	DNA-binding transcription factor activity
K6754_02530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6754_02535	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K6754_02540	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K6754_02550	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K6754_02555	COG3079	Belongs to the UPF0149 family
K6754_02560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6754_02565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6754_02580	COG0354	folic acid binding
K6754_02585	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K6754_02590	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K6754_02595	COG1595	DNA-templated transcription, initiation
K6754_02610	COG3086	response to oxidative stress
K6754_02615	COG0481	GTPase activity
K6754_02620	COG0681	Belongs to the peptidase S26 family
K6754_02630	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K6754_02635	COG1381	Involved in DNA repair and RecF pathway recombination
K6754_02640	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K6754_02655	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K6754_02660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K6754_02665	COG3956	TIGRFAM MazG family protein
K6754_02670	COG0504	CTP synthase activity
K6754_02675	COG0148	phosphopyruvate hydratase activity
K6754_02680	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K6754_02685	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K6754_02690	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K6754_02700	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K6754_02705	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K6754_02715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K6754_02720	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K6754_02725	COG1546	Belongs to the CinA family
K6754_02730	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K6754_02735	COG2137	regulation of response to DNA damage stimulus
K6754_02740	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K6754_02745	COG0527	aspartate kinase activity
K6754_02805	COG3630	sodium ion export across plasma membrane
K6754_02810	COG0511	ligase activity, forming carbon-carbon bonds
K6754_02810	COG5016	pyruvate
K6754_02815	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K6754_02825	COG1238	metal cluster binding
K6754_02830	COG0612	Peptidase, M16
K6754_02845	COG1854	S-ribosylhomocysteine lyase activity
K6754_02850	COG4536	flavin adenine dinucleotide binding
K6754_02855	COG4137	Cytochrome C assembly protein
K6754_02860	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K6754_02865	COG0228	four-way junction DNA binding
K6754_02870	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K6754_02885	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K6754_02890	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
K6754_02895	COG0237	dephospho-CoA kinase activity
K6754_02905	COG1459	type II secretion system
K6754_02910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K6754_02920	COG0157	Belongs to the NadC ModD family
K6754_02930	COG2186	Transcriptional regulator
K6754_02935	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K6754_02940	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6754_02945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6754_02960	COG0288	reversible hydration of carbon dioxide
K6754_02965	COG0659	secondary active sulfate transmembrane transporter activity
K6754_02970	COG1131	(ABC) transporter
K6754_02975	COG0842	Transport permease protein
K6754_02980	COG1560	Kdo2-lipid A biosynthetic process
K6754_02985	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K6754_02990	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K6754_02995	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K6754_03005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K6754_03015	COG1489	DNA binding
K6754_03020	COG1643	Atp-dependent helicase
K6754_03025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6754_03030	COG1752	Esterase of the alpha-beta hydrolase superfamily
K6754_03035	COG1049	propionate catabolic process, 2-methylcitrate cycle
K6754_03040	COG3112	Uncharacterised protein family (UPF0231)
K6754_03050	COG0004	ammonium transporteR
K6754_03055	COG1840	ABC-type Fe3 transport system, periplasmic component
K6754_03065	COG3842	ATPase activity
K6754_03070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6754_03085	COG2971	BadF BadG BcrA BcrD
K6754_03095	COG4608	Belongs to the ABC transporter superfamily
K6754_03100	COG0444	Belongs to the ABC transporter superfamily
K6754_03105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6754_03115	COG0747	negative chemotaxis
K6754_03120	COG2205	protein histidine kinase activity
K6754_03120	COG0784	Response regulator, receiver
K6754_03130	COG0628	permease
K6754_03155	COG0739	heme binding
K6754_03160	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K6754_03170	COG2027	D-alanyl-D-alanine carboxypeptidase
K6754_03175	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6754_03180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6754_03185	COG1534	Rna-binding protein
K6754_03190	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K6754_03195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K6754_03200	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K6754_03205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6754_03210	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K6754_03225	COG0779	Required for maturation of 30S ribosomal subunits
K6754_03230	COG0195	Participates in both transcription termination and antitermination
K6754_03235	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K6754_03240	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K6754_03245	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K6754_03250	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K6754_03255	COG1185	polyribonucleotide nucleotidyltransferase activity
K6754_03270	COG0534	Mate efflux family protein
K6754_03275	COG0826	peptidase U32
K6754_03280	COG0826	peptidase U32
K6754_03290	COG3154	lipid carrier protein
K6754_03295	COG3153	acetyltransferase
K6754_03325	COG0084	hydrolase, TatD family'
K6754_03330	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6754_03335	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K6754_03340	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K6754_03345	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K6754_03350	COG0813	purine-nucleoside phosphorylase activity
K6754_03360	COG0560	Phosphoserine phosphatase
K6754_03370	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K6754_03375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K6754_03380	COG0583	DNA-binding transcription factor activity
K6754_03390	COG1022	Amp-dependent synthetase and ligase
K6754_03430	COG0583	DNA-binding transcription factor activity
K6754_03435	COG1609	Transcriptional regulator
K6754_03455	COG0598	Magnesium transport protein CorA
K6754_03460	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K6754_03465	COG1349	DNA-binding transcription factor activity
K6754_03470	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K6754_03475	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K6754_03480	COG2271	Major facilitator Superfamily
K6754_03485	COG0584	glycerophosphoryl diester phosphodiesterase
K6754_03490	COG2171	N-acyltransferase activity
K6754_03505	COG3141	response to X-ray
K6754_03525	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K6754_03530	COG1074	ATP-dependent DNA helicase activity
K6754_03535	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K6754_03545	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K6754_03545	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K6754_03555	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
K6754_03560	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K6754_03565	COG2166	iron-sulfur cluster assembly
K6754_03570	COG3706	GGDEF domain
K6754_03575	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K6754_03580	COG0693	protein deglycase activity
K6754_03585	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K6754_03605	COG1595	DNA-templated transcription, initiation
K6754_03625	COG3056	Lipoprotein
K6754_03630	COG2813	Specifically methylates the guanine in position
K6754_03635	COG0271	Belongs to the BolA IbaG family
K6754_03640	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6754_03645	COG1805	sodium ion transport
K6754_03650	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6754_03655	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6754_03660	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6754_03665	COG2871	sodium ion transport
K6754_03670	COG1477	protein flavinylation
K6754_03690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K6754_03695	COG0514	ATP-dependent DNA helicase (RecQ)
K6754_03715	COG0733	neurotransmitter:sodium symporter activity
K6754_03735	COG0442	prolyl-tRNA aminoacylation
K6754_03740	COG1720	tRNA m6t6A37 methyltransferase activity
K6754_03745	COG0254	rRNA binding
K6754_03755	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K6754_03780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6754_03820	COG0564	pseudouridine synthase activity
K6754_03830	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K6754_03835	COG0024	Methionine aminopeptidase
K6754_03840	COG0052	Belongs to the universal ribosomal protein uS2 family
K6754_03845	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K6754_03850	COG0528	UMP kinase activity
K6754_03855	COG0233	cytoplasmic translational termination
K6754_03860	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K6754_03865	COG0575	Belongs to the CDS family
K6754_03870	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K6754_03875	COG0750	zinc metalloprotease
K6754_03885	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
K6754_03890	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6754_03900	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6754_03905	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6754_03915	COG0587	DNA-directed DNA polymerase activity
K6754_03920	COG0825	malonyl-CoA metabolic process
K6754_03935	COG0347	Belongs to the P(II) protein family
K6754_03940	COG3021	interspecies interaction between organisms
K6754_03950	COG1388	LysM domain
K6754_03950	COG0741	lytic transglycosylase activity
K6754_03955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6754_03960	COG2226	methyltransferase
K6754_04000	COG1960	acyl-CoA dehydrogenase activity
K6754_04005	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K6754_04010	COG0121	glutamine amidotransferase
K6754_04015	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K6754_04020	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K6754_04025	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K6754_04030	COG2233	PERMEase
K6754_04050	COG1393	Belongs to the ArsC family
K6754_04055	COG4783	chaperone-mediated protein folding
K6754_04070	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K6754_04080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6754_04085	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
K6754_04100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6754_04105	COG1393	Belongs to the ArsC family
K6754_04130	COG2837	iron assimilation
K6754_04135	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6754_04140	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6754_04145	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6754_04150	COG1334	flagellar protein FlaG
K6754_04155	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K6754_04165	COG1516	flagellar protein fliS
K6754_04185	COG1677	Flagellar hook-basal body complex protein FliE
K6754_04195	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K6754_04250	COG1987	bacterial-type flagellum assembly
K6754_04255	COG1684	flagellar biosynthetic protein fliR
K6754_04290	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
K6754_04295	COG2198	Histidine kinase
K6754_04295	COG0643	Histidine kinase
K6754_04295	COG0784	Response regulator, receiver
K6754_04300	COG2201	protein-glutamate methylesterase activity
K6754_04305	COG1192	Involved in chromosome partitioning
K6754_04315	COG0835	chemotaxis
K6754_04325	COG4133	protoheme IX ABC transporter activity
K6754_04330	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6754_04335	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6754_04340	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6754_04345	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K6754_04350	COG1138	Cytochrome C-type biogenesis protein
K6754_04355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6754_04365	COG3088	subunit of a heme lyase
K6754_04365	COG4235	cytochrome complex assembly
K6754_04375	COG2067	long-chain fatty acid transport protein
K6754_04395	COG0183	Belongs to the thiolase family
K6754_04400	COG1024	Enoyl-CoA hydratase
K6754_04400	COG1250	3-hydroxyacyl-CoA dehydrogenase
K6754_04415	COG2062	phosphohistidine phosphatase, SixA
K6754_04420	COG2840	Smr protein MutS2
K6754_04425	COG2890	protein-(glutamine-N5) methyltransferase activity
K6754_04430	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K6754_04435	COG2860	membrane
K6754_04440	COG3101	peptidyl-lysine hydroxylation
K6754_04455	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K6754_04455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6754_04460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K6754_04465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6754_04470	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K6754_04480	COG0101	tRNA pseudouridine synthase activity
K6754_04485	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K6754_04490	COG0285	dihydrofolate synthase activity
K6754_04495	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
K6754_04500	COG1286	toxin biosynthetic process
K6754_04505	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K6754_04510	COG0583	DNA-binding transcription factor activity
K6754_04515	COG0745	RESPONSE REGULATOR receiver
K6754_04520	COG2832	Protein of unknown function (DUF454)
K6754_04525	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K6754_04540	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K6754_04545	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K6754_04555	COG2261	transglycosylase associated protein
K6754_04560	COG2983	Belongs to the UPF0260 family
K6754_04565	COG0668	transmembrane transport
K6754_04570	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
K6754_04575	COG0346	lactoylglutathione lyase activity
K6754_04585	COG1785	Belongs to the alkaline phosphatase family
K6754_04600	COG2226	methyltransferase
K6754_04615	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K6754_04620	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6754_04630	COG3139	Protein of unknown function (DUF1315)
K6754_04635	COG0252	asparaginase activity
K6754_04640	COG0616	signal peptide processing
K6754_04645	COG1902	pentaerythritol trinitrate reductase activity
K6754_04645	COG0446	pyridine nucleotide-disulphide oxidoreductase
K6754_04655	COG0778	Nitroreductase
K6754_04660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K6754_04690	COG3082	Protein of unknown function (DUF1414)
K6754_04695	COG3081	Nucleoid-associated protein
K6754_04710	COG1757	Na H antiporter
K6754_04715	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K6754_04720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6754_04725	COG2095	MarC family integral membrane protein
K6754_04730	COG1012	belongs to the aldehyde dehydrogenase family
K6754_04730	COG1454	alcohol dehydrogenase
K6754_04750	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K6754_04755	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K6754_04840	COG4695	Portal protein
K6754_04980	COG2056	Na+-H+ antiporter family
K6754_04985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K6754_04990	COG2885	chlorophyll binding
K6754_05000	COG0346	lactoylglutathione lyase activity
K6754_05005	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K6754_05010	COG4660	Part of a membrane complex involved in electron transport
K6754_05015	COG4659	FMN binding
K6754_05020	COG4658	electron transport chain
K6754_05025	COG4656	Part of a membrane complex involved in electron transport
K6754_05030	COG2878	Part of a membrane complex involved in electron transport
K6754_05035	COG4657	Part of a membrane complex involved in electron transport
K6754_05040	COG1882	Formate acetyltransferase
K6754_05050	COG0556	nucleotide-excision repair
K6754_05055	COG2204	response regulator
K6754_05060	COG2198	Histidine kinase
K6754_05065	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K6754_05070	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K6754_05075	COG0521	Mo-molybdopterin cofactor biosynthetic process
K6754_05080	COG0315	cyclic pyranopterin monophosphate synthase activity
K6754_05085	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K6754_05090	COG0314	molybdopterin synthase activity
K6754_05100	COG0601	transmembrane transport
K6754_05105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6754_05110	COG0444	Belongs to the ABC transporter superfamily
K6754_05120	COG0435	Glutathione S-transferase
K6754_05130	COG0857	belongs to the CobB CobQ family
K6754_05130	COG0280	phosphate acetyltransferase
K6754_05135	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K6754_05140	COG3092	negative regulation of chromosome organization
K6754_05150	COG4120	Belongs to the binding-protein-dependent transport system permease family
K6754_05155	COG1122	ATPase activity
K6754_05160	COG0366	Alpha amylase catalytic
K6754_05165	COG3706	GGDEF domain
K6754_05170	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6754_05175	COG0653	protein targeting
K6754_05180	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K6754_05185	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K6754_05190	COG2186	Transcriptional regulator
K6754_05210	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6754_05210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6754_05220	COG0572	uridine kinase
K6754_05230	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
K6754_05235	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K6754_05240	COG0659	secondary active sulfate transmembrane transporter activity
K6754_05245	COG1530	ribonuclease E activity
K6754_05250	COG0564	pseudouridine synthase activity
K6754_05255	COG0424	maF-like protein
K6754_05260	COG1399	metal-binding, possibly nucleic acid-binding protein
K6754_05270	COG0416	fatty acid biosynthetic process
K6754_05275	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6754_05305	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K6754_05310	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K6754_05315	COG0470	DNA polymerase III
K6754_05320	COG0084	hydrolase, TatD family'
K6754_05325	COG1263	PTS System
K6754_05325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6754_05340	COG0733	neurotransmitter:sodium symporter activity
K6754_05355	COG4667	esterase of the alpha-beta hydrolase superfamily
K6754_05360	COG0469	pyruvate kinase activity
K6754_05365	COG1940	carbohydrate kinase activity
K6754_05370	COG0835	chemotaxis
K6754_05370	COG0784	Response regulator, receiver
K6754_05375	COG0587	DNA-directed DNA polymerase activity
K6754_05390	COG1028	Short-chain dehydrogenase reductase Sdr
K6754_05395	COG0616	signal peptide processing
K6754_05400	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K6754_05405	COG0539	negative regulation of cytoplasmic translation
K6754_05415	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
K6754_05420	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K6754_05430	COG4166	transmembrane transport
K6754_05450	COG3008	intermembrane lipid transfer
K6754_05450	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K6754_05455	COG2995	paraquat-inducible protein a
K6754_05460	COG3258	Cytochrome c
K6754_05465	COG2863	cytochrome
K6754_05500	COG4232	protein-disulfide reductase activity
K6754_05505	COG3118	belongs to the thioredoxin family
K6754_05525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6754_05535	COG0577	efflux transmembrane transporter activity
K6754_05535	COG1136	(ABC) transporter
K6754_05540	COG0577	efflux transmembrane transporter activity
K6754_05540	COG1136	(ABC) transporter
K6754_05545	COG1136	(ABC) transporter
K6754_05545	COG0577	efflux transmembrane transporter activity
K6754_05595	COG3850	Histidine kinase
K6754_05595	COG5002	protein histidine kinase activity
K6754_05600	COG0745	RESPONSE REGULATOR receiver
K6754_05605	COG0463	Glycosyl transferase, family 2
K6754_05610	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K6754_05630	COG1032	radical SAM domain protein
K6754_05635	COG5001	Diguanylate cyclase
K6754_05650	COG0583	DNA-binding transcription factor activity
K6754_05655	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K6754_05665	COG2350	Protein conserved in bacteria
K6754_05675	COG2917	probably involved in intracellular septation
K6754_05695	COG1301	dicarboxylic acid transport
K6754_05700	COG0318	PFAM AMP-dependent synthetase and ligase
K6754_05705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6754_05710	COG0159	tryptophan synthase activity
K6754_05720	COG0134	indole-3-glycerol-phosphate synthase activity
K6754_05720	COG0135	phosphoribosylanthranilate isomerase activity
K6754_05730	COG0512	Glutamine amidotransferase of anthranilate synthase
K6754_05735	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K6754_05745	COG0613	PHP domain protein
K6754_05750	COG0009	L-threonylcarbamoyladenylate synthase
K6754_05760	COG1187	pseudouridine synthase activity
K6754_05780	COG0417	DNA replication proofreading
K6754_05785	COG2197	response regulator
K6754_05790	COG0322	excinuclease ABC activity
K6754_05830	COG0019	diaminopimelate decarboxylase activity
K6754_05860	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K6754_05865	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K6754_05885	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
K6754_05895	COG0437	4 iron, 4 sulfur cluster binding
K6754_05900	COG3301	Polysulphide reductase, NrfD
K6754_05905	COG1138	Cytochrome C-type biogenesis protein
K6754_05915	COG3088	subunit of a heme lyase
K6754_05915	COG4235	cytochrome complex assembly
K6754_05925	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6754_05950	COG2989	Protein conserved in bacteria
K6754_05955	COG3108	Peptidase M15
K6754_05960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6754_05975	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K6754_06005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6754_06010	COG0840	transmembrane signaling receptor activity
K6754_06030	COG1448	Aminotransferase
K6754_06045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6754_06055	COG0017	Asparaginyl-tRNA synthetase
K6754_06060	COG0840	transmembrane signaling receptor activity
K6754_06065	COG0720	synthase
K6754_06075	COG2200	EAL domain
K6754_06080	COG1760	l-serine dehydratase
K6754_06085	COG0814	amino acid
K6754_06090	COG0494	nUDIX hydrolase
K6754_06100	COG0784	Response regulator, receiver
K6754_06100	COG2205	protein histidine kinase activity
K6754_06105	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K6754_06120	COG3106	COG3106 Predicted ATPase
K6754_06125	COG3768	UPF0283 membrane protein
K6754_06135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6754_06155	COG0791	NLP P60 protein
K6754_06295	COG2801	Transposase and inactivated derivatives
K6754_06310	COG1683	Conserved Protein
K6754_06430	COG2801	Transposase and inactivated derivatives
K6754_06620	COG2801	Transposase and inactivated derivatives
K6754_06735	COG2801	Transposase and inactivated derivatives
K6754_06770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6754_06790	COG1629	transport
K6754_06790	COG4774	siderophore transport
K6754_06795	COG2382	esterase
K6754_06810	COG1120	ATPase activity
K6754_06815	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6754_06820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6754_06830	COG4592	Periplasmic binding protein
K6754_06835	COG1535	isochorismatase
K6754_06835	COG3433	isochorismatase activity
K6754_06840	COG1021	2,3-dihydroxybenzoate-AMP ligase
K6754_06845	COG1169	isochorismate synthase
K6754_06850	COG1028	Short-chain dehydrogenase reductase Sdr
K6754_06855	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K6754_06930	COG0110	maltose O-acetyltransferase activity
K6754_06940	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K6754_06960	COG5507	3-demethylubiquinone-9 3-methyltransferase
K6754_06965	COG1280	lysine exporter protein (LysE YggA)
K6754_06970	COG1280	lysine exporter protein (LysE YggA)
K6754_06980	COG0729	surface antigen
K6754_06985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6754_06990	COG2272	Belongs to the type-B carboxylesterase lipase family
K6754_07015	COG2985	domain, Protein
K6754_07025	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K6754_07055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6754_07070	COG3290	protein histidine kinase activity
K6754_07075	COG4565	transcriptional regulatory protein
K6754_07085	COG2207	Transcriptional regulator
K6754_07090	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K6754_07095	COG0363	glucosamine-6-phosphate deaminase activity
K6754_07100	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K6754_07115	COG3284	Transcriptional regulator
K6754_07120	COG1012	belongs to the aldehyde dehydrogenase family
K6754_07190	COG4669	(LipO)protein
K6754_07210	COG3177	Filamentation induced by cAMP protein fic
K6754_07240	COG2207	Transcriptional regulator
K6754_07245	COG4792	protein secretion
K6754_07250	COG4791	protein targeting
K6754_07255	COG4794	Type iii secretion
K6754_07260	COG4790	Type iii secretion
K6754_07330	COG0457	Tetratricopeptide repeat
K6754_07345	COG2358	TRAP transporter, solute receptor (TAXI family
K6754_07350	COG0730	response to heat
K6754_07385	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K6754_07390	COG0372	Belongs to the citrate synthase family
K6754_07400	COG2828	Protein conserved in bacteria
K6754_07425	COG0561	phosphatase activity
K6754_07430	COG0602	queuosine metabolic process
K6754_07435	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K6754_07450	COG0583	DNA-binding transcription factor activity
K6754_07455	COG0583	DNA-binding transcription factor activity
K6754_07470	COG0583	DNA-binding transcription factor activity
K6754_07485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6754_07490	COG0765	amino acid transport
K6754_07495	COG1126	abc transporter atp-binding protein
K6754_07500	COG0646	methionine synthase
K6754_07500	COG1410	methionine synthase
K6754_07520	COG1335	isochorismatase
K6754_07530	COG0604	alcohol dehydrogenase
K6754_07540	COG2814	Major facilitator Superfamily
K6754_07545	COG0583	DNA-binding transcription factor activity
K6754_07555	COG0583	DNA-binding transcription factor activity
K6754_07560	COG0656	L-ascorbic acid biosynthetic process
K6754_07575	COG3423	Transcriptional regulator
K6754_07580	COG2801	Transposase and inactivated derivatives
K6754_07585	COG2842	Transposition protein
K6754_07700	COG0640	Transcriptional regulator
K6754_07715	COG4373	Mu-like prophage FluMu protein gp28
K6754_07720	COG4383	Mu-like prophage protein gp29
K6754_07735	COG4397	Mu-like prophage major head subunit gpT
K6754_07755	COG4387	Mu-like prophage protein GP36
K6754_07775	COG4386	tail sheath protein
K6754_07785	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
K6754_07815	COG3299	homolog of phage Mu protein gp47
K6754_07820	COG3778	Protein conserved in bacteria
K6754_07835	COG1414	Transcriptional regulator
K6754_07840	COG2199	diguanylate cyclase activity
K6754_07840	COG2203	Gaf domain
K6754_07865	COG2885	chlorophyll binding
K6754_07890	COG1254	Belongs to the acylphosphatase family
K6754_07895	COG2920	part of a sulfur-relay system
K6754_07905	COG0670	Belongs to the BI1 family
K6754_07910	COG1126	abc transporter atp-binding protein
K6754_07915	COG0765	amino acid transport
K6754_07920	COG4597	amino acid ABC transporter
K6754_07925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6754_07935	COG1666	GTP binding
K6754_07940	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K6754_07965	COG3008	intermembrane lipid transfer
K6754_07970	COG2995	paraquat-inducible protein a
K6754_07975	COG1132	(ABC) transporter
K6754_07980	COG1956	GAF domain-containing protein
K6754_07985	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
K6754_08000	COG0308	aminopeptidase N
K6754_08010	COG2902	Dehydrogenase
K6754_08015	COG0167	dihydroorotate dehydrogenase activity
K6754_08025	COG0116	Belongs to the methyltransferase superfamily
K6754_08025	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K6754_08035	COG0488	(ABC) transporter
K6754_08050	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K6754_08055	COG1067	ATP-dependent peptidase activity
K6754_08060	COG3120	sequence-specific DNA binding
K6754_08190	COG0784	Response regulator, receiver
K6754_08190	COG2205	protein histidine kinase activity
K6754_08205	COG3278	Belongs to the heme-copper respiratory oxidase family
K6754_08220	COG2010	Cytochrome c
K6754_08230	COG2217	Heavy metal translocating P-type atpase
K6754_08245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6754_08250	COG0589	response to stress
K6754_08275	COG3842	ATPase activity
K6754_08285	COG1177	transmembrane transport
K6754_08295	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K6754_08300	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K6754_08310	COG0004	ammonium transporteR
K6754_08335	COG0437	4 iron, 4 sulfur cluster binding
K6754_08340	COG0243	molybdopterin cofactor binding
K6754_08340	COG3383	formate dehydrogenase (NAD+) activity
K6754_08350	COG3381	protein complex oligomerization
K6754_08370	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K6754_08375	COG0488	(ABC) transporter
K6754_08380	COG4191	Histidine kinase
K6754_08385	COG2204	response regulator
K6754_08400	COG3842	ATPase activity
K6754_08405	COG0746	molybdenum cofactor guanylyltransferase activity
K6754_08410	COG0303	'Molybdopterin
K6754_08420	COG1940	carbohydrate kinase activity
K6754_08425	COG3148	PFAM DTW domain containing protein
K6754_08460	COG0791	NLP P60 protein
K6754_08470	COG3706	GGDEF domain
K6754_08480	COG3001	Fructosamine kinase
K6754_08490	COG0307	riboflavin synthase, alpha
K6754_08495	COG0534	Mate efflux family protein
K6754_08505	COG1793	dna ligase
K6754_08535	COG2204	response regulator
K6754_08540	COG0297	glycogen (starch) synthase activity
K6754_08545	COG0438	transferase activity, transferring glycosyl groups
K6754_08575	COG0438	transferase activity, transferring glycosyl groups
K6754_08580	COG1215	transferase activity, transferring glycosyl groups
K6754_08585	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6754_08595	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6754_08610	COG1643	Atp-dependent helicase
K6754_08615	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K6754_08660	COG0443	Heat shock 70 kDa protein
K6754_08665	COG0443	Heat shock 70 kDa protein
K6754_08690	COG0583	DNA-binding transcription factor activity
K6754_08710	COG1132	(ABC) transporter
K6754_08715	COG1132	(ABC) transporter
K6754_08725	COG4774	siderophore transport
K6754_08735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6754_08740	COG1120	ATPase activity
K6754_08755	COG0814	amino acid
K6754_08765	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K6754_08775	COG0861	Integral membrane protein TerC family
K6754_08785	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K6754_08790	COG1328	CTP reductase activity
K6754_08805	COG5001	Diguanylate cyclase
K6754_08805	COG3300	MHYT domain
K6754_08820	COG0471	metal ion transport
K6754_08845	COG4702	Belongs to the UPF0303 family
K6754_08850	COG0673	inositol 2-dehydrogenase activity
K6754_08855	COG1349	DNA-binding transcription factor activity
K6754_08870	COG1538	Outer membrane efflux protein
K6754_08895	COG3119	arylsulfatase activity
K6754_08910	COG0641	radical SAM
K6754_08925	COG3119	arylsulfatase activity
K6754_08930	COG0527	aspartate kinase activity
K6754_08935	COG0662	Cupin 2, conserved barrel domain protein
K6754_08940	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K6754_08945	COG0456	acetyltransferase
K6754_08950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6754_08970	COG4176	ABC-type proline glycine betaine transport system permease component
K6754_08975	COG2113	Glycine betaine
K6754_08980	COG1368	sulfuric ester hydrolase activity
K6754_09005	COG1115	amino acid carrier protein
K6754_09015	COG1280	lysine exporter protein (LysE YggA)
K6754_09020	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K6754_09025	COG1560	Kdo2-lipid A biosynthetic process
K6754_09040	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K6754_09045	COG3063	Type IV pilus biogenesis stability protein PilW
K6754_09085	COG2315	Protein conserved in bacteria
K6754_09090	COG1846	Transcriptional regulator
K6754_09100	COG2200	EAL domain
K6754_09105	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K6754_09110	COG1012	belongs to the aldehyde dehydrogenase family
K6754_09115	COG2957	Belongs to the agmatine deiminase family
K6754_09125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6754_09130	COG1012	belongs to the aldehyde dehydrogenase family
K6754_09135	COG1396	sequence-specific DNA binding
K6754_09135	COG1917	Cupin 2, conserved barrel domain protein
K6754_09140	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K6754_09145	COG0174	glutamine synthetase
K6754_09150	COG1757	Na H antiporter
K6754_09165	COG1742	UPF0060 membrane protein
K6754_09190	COG3755	Protein conserved in bacteria
K6754_09235	COG0625	glutathione transferase activity
K6754_09245	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K6754_09255	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6754_09265	COG0601	transmembrane transport
K6754_09270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6754_09290	COG3291	Pkd domain containing protein
K6754_09300	COG1177	transmembrane transport
K6754_09305	COG1176	ABC-type spermidine putrescine transport system, permease component I
K6754_09310	COG3842	ATPase activity
K6754_09315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6754_09320	COG2423	ornithine cyclodeaminase activity
K6754_09335	COG3938	Belongs to the proline racemase family
K6754_09365	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
K6754_09370	COG1451	nucleotide metabolic process
K6754_09380	COG0583	DNA-binding transcription factor activity
K6754_09400	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
K6754_09405	COG4139	cobalamin transport
K6754_09410	COG2988	succinylglutamate desuccinylase activity
K6754_09430	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K6754_09435	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K6754_09440	COG0702	epimerase
K6754_09445	COG1823	symporter activity
K6754_09450	COG2925	Exonuclease
K6754_09455	COG1380	Effector of murein hydrolase LrgA
K6754_09460	COG1346	cytolysis
K6754_09465	COG0295	cytidine deaminase activity
K6754_09470	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K6754_09475	COG0500	methyltransferase
K6754_09485	COG0776	regulation of translation
K6754_09495	COG0072	phenylalanine-tRNA ligase activity
K6754_09495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6754_09500	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K6754_09530	COG0393	Putative heavy-metal-binding
K6754_09540	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K6754_09550	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K6754_09565	COG2188	Transcriptional regulator
K6754_09570	COG1228	amidohydrolase
K6754_09575	COG0010	Belongs to the arginase family
K6754_09580	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K6754_09585	COG2986	histidine ammonia-lyase
K6754_09600	COG0277	FAD linked oxidase domain protein
K6754_09600	COG0247	lactate metabolic process
K6754_09635	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K6754_09650	COG1643	Atp-dependent helicase
K6754_09655	COG0281	malic enzyme
K6754_09660	COG2949	membrane
K6754_09665	COG0471	metal ion transport
K6754_09690	COG0492	ferredoxin-NADP+ reductase activity
K6754_09695	COG4988	ABC transporter
K6754_09700	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K6754_09710	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K6754_09720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6754_09720	COG4191	Histidine kinase
K6754_09735	COG3070	regulator of competence-specific genes
K6754_09745	COG2431	L-lysine efflux transmembrane transporter activity
K6754_09755	COG0076	glutamate decarboxylase activity
K6754_09760	COG1737	Transcriptional regulator
K6754_09770	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K6754_09775	COG2985	domain, Protein
K6754_09775	COG3273	potassium ion transport
K6754_09780	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K6754_09785	COG1960	acyl-CoA dehydrogenase activity
K6754_09795	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K6754_09815	COG0534	Mate efflux family protein
K6754_09820	COG0702	epimerase
K6754_09830	COG2814	Major facilitator Superfamily
K6754_09835	COG1187	pseudouridine synthase activity
K6754_09840	COG1061	Type III restriction enzyme res subunit
K6754_09860	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K6754_09880	COG3313	Fe-S protein
K6754_09890	COG4134	Bacterial extracellular solute-binding protein
K6754_09895	COG4135	transport system, permease component
K6754_09900	COG4136	ATPase activity
K6754_09905	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K6754_09915	COG3604	Transcriptional regulator
K6754_09920	COG1151	hydroxylamine reductase activity
K6754_09925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K6754_09935	COG0564	pseudouridine synthase activity
K6754_09940	COG0733	neurotransmitter:sodium symporter activity
K6754_09950	COG0626	cystathionine gamma-synthase activity
K6754_09955	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
K6754_09960	COG5380	lipid catabolic process
K6754_09965	COG2818	Glycosylase
K6754_09985	COG1983	PspC domain protein
K6754_09995	COG1842	Phage shock protein A
K6754_10000	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K6754_10015	COG4171	peptide transport system, permease
K6754_10025	COG4172	Belongs to the ABC transporter superfamily
K6754_10035	COG1227	inorganic diphosphatase activity
K6754_10050	COG0243	molybdopterin cofactor binding
K6754_10055	COG3005	denitrification pathway
K6754_10060	COG4459	periplasmic nitrate reductase
K6754_10065	COG0390	transport system, permease component
K6754_10075	COG2116	formate transmembrane transporter activity
K6754_10105	COG1435	thymidine kinase activity
K6754_10110	COG0215	cysteine-tRNA ligase activity
K6754_10115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K6754_10120	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6754_10125	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K6754_10130	COG3012	SEC-C Motif Domain Protein
K6754_10135	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K6754_10135	COG0140	phosphoribosyl-ATP diphosphatase activity
K6754_10145	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K6754_10150	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K6754_10155	COG0131	Imidazoleglycerol-phosphate dehydratase
K6754_10155	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K6754_10165	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K6754_10175	COG1757	Na H antiporter
K6754_10185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6754_10200	COG2915	High frequency lysogenization protein hflD homolog
K6754_10205	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K6754_10215	COG2268	Band 7 protein
K6754_10225	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K6754_10240	COG0300	oxidoreductase activity
K6754_10260	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K6754_10285	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K6754_10305	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K6754_10315	COG1674	ftsk spoiiie
K6754_10325	COG0686	Belongs to the AlaDH PNT family
K6754_10335	COG0583	DNA-binding transcription factor activity
K6754_10360	COG3568	Endonuclease Exonuclease Phosphatase
K6754_10385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6754_10390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6754_10410	COG1271	oxidase subunit
K6754_10415	COG1294	oxidase, subunit
K6754_10430	COG5002	protein histidine kinase activity
K6754_10430	COG0784	Response regulator, receiver
K6754_10440	COG0754	glutathionylspermidine amidase activity
K6754_10450	COG3766	membrane
K6754_10460	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K6754_10465	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
K6754_10470	COG2885	chlorophyll binding
K6754_10475	COG0823	Involved in the tonB-independent uptake of proteins
K6754_10490	COG0811	peptide transport
K6754_10495	COG0824	Thioesterase
K6754_10505	COG4890	Cyd operon protein YbgT
K6754_10510	COG1294	oxidase, subunit
K6754_10515	COG1271	oxidase subunit
K6754_10520	COG2255	four-way junction helicase activity
K6754_10525	COG0632	four-way junction helicase activity
K6754_10530	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K6754_10535	COG0217	transcriptional regulatory protein
K6754_10545	COG1801	Protein of unknown function DUF72
K6754_10555	COG0500	methyltransferase
K6754_10560	COG4067	protein conserved in archaea
K6754_10560	COG0189	ligase activity
K6754_10580	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K6754_10585	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
K6754_10590	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
K6754_10595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K6754_10600	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K6754_10605	COG0745	RESPONSE REGULATOR receiver
K6754_10610	COG3381	protein complex oligomerization
K6754_10615	COG1609	Transcriptional regulator
K6754_10620	COG3070	regulator of competence-specific genes
K6754_10640	COG0297	glycogen (starch) synthase activity
K6754_10645	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K6754_10650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K6754_10670	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K6754_10675	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K6754_10680	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K6754_10685	COG0542	response to heat
K6754_10690	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K6754_10695	COG1278	Cold shock
K6754_10705	COG1187	pseudouridine synthase activity
K6754_10710	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K6754_10715	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6754_10720	COG1199	ATP-dependent helicase activity
K6754_10725	COG0730	response to heat
K6754_10730	COG3923	Primosomal replication protein n
K6754_10740	COG0708	Exodeoxyribonuclease III
K6754_10780	COG1882	Formate acetyltransferase
K6754_10790	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K6754_10800	COG3013	Belongs to the UPF0304 family
K6754_10805	COG2766	serine protein kinase
K6754_10810	COG2718	Belongs to the UPF0229 family
K6754_10815	COG2719	SpoVR family
K6754_10835	COG1132	(ABC) transporter
K6754_10840	COG0658	competence protein
K6754_10840	COG2333	competence protein COMEC
K6754_10850	COG4591	ABC-type transport system involved in lipoprotein release permease component
K6754_10855	COG1136	(ABC) transporter
K6754_10860	COG4591	ABC-type transport system involved in lipoprotein release permease component
K6754_10870	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K6754_10885	COG1252	NADH dehydrogenase
K6754_10890	COG3150	esterase
K6754_10915	COG0537	adenosine 5'-monophosphoramidase activity
K6754_10940	COG0517	IMP dehydrogenase activity
K6754_10940	COG0516	GMP reductase activity
K6754_10945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6754_10970	COG3126	Type III secretion system lipoprotein chaperone (YscW)
K6754_10975	COG1946	Acyl-CoA thioesterase
K6754_10985	COG1522	sequence-specific DNA binding
K6754_10990	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6754_11005	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6754_11010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6754_11055	COG0477	Major facilitator Superfamily
K6754_11060	COG2855	membrane
K6754_11080	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K6754_11095	COG1169	isochorismate synthase
K6754_11100	COG0436	Aminotransferase
K6754_11105	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K6754_11110	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K6754_11125	COG1555	photosystem II stabilization
K6754_11130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6754_11135	COG0776	regulation of translation
K6754_11140	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K6754_11145	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K6754_11155	COG0544	peptidyl-prolyl cis-trans isomerase activity
K6754_11170	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K6754_11175	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K6754_11180	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K6754_11185	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K6754_11200	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6754_11205	COG0569	domain protein
K6754_11210	COG0513	Belongs to the DEAD box helicase family
K6754_11245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6754_11250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6754_11265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K6754_11270	COG1216	Glycosyl transferase, family 2
K6754_11275	COG2986	histidine ammonia-lyase
K6754_11300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K6754_11310	COG1028	Short-chain dehydrogenase reductase Sdr
K6754_11325	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K6754_11330	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6754_11340	COG2951	lytic endotransglycosylase activity
K6754_11345	COG3100	YcgL domain-containing protein
K6754_11350	COG0850	regulation of cytokinetic process
K6754_11355	COG2894	cell division
K6754_11360	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K6754_11365	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K6754_11370	COG0318	PFAM AMP-dependent synthetase and ligase
K6754_11375	COG2267	carboxylic ester hydrolase activity
K6754_11380	COG3065	identical protein binding
K6754_11390	COG1214	PFAM Peptidase M22, glycoprotease
K6754_11395	COG1199	ATP-dependent helicase activity
K6754_11400	COG0788	formyltetrahydrofolate deformylase activity
K6754_11415	COG3102	Protein conserved in bacteria
K6754_11420	COG0018	arginyl-trna synthetase
K6754_11445	COG1918	ferrous iron import across plasma membrane
K6754_11450	COG4977	sequence-specific DNA binding
K6754_11455	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
K6754_11460	COG1121	(ABC) transporter
K6754_11465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K6754_11475	COG0045	succinate-CoA ligase (ADP-forming) activity
K6754_11480	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6754_11485	COG0567	Dehydrogenase, E1 component
K6754_11490	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K6754_11495	COG1053	succinate dehydrogenase
K6754_11500	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K6754_11515	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K6754_11525	COG0033	Phosphoglucomutase
K6754_11530	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
K6754_11535	COG0596	Alpha beta hydrolase
K6754_11545	COG0716	FMN binding
K6754_11555	COG0735	belongs to the Fur family
K6754_11560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K6754_11565	COG1263	PTS System
K6754_11565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6754_11565	COG2190	(PTS) system
K6754_11570	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K6754_11575	COG1846	Transcriptional regulator
K6754_11575	COG1940	carbohydrate kinase activity
K6754_11580	COG4651	solute:proton antiporter activity
K6754_11580	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K6754_11585	COG0367	asparagine synthase
K6754_11590	COG0250	Participates in transcription elongation, termination and antitermination
K6754_11595	COG3104	oligopeptide transport
K6754_11600	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K6754_11610	COG0326	Molecular chaperone. Has ATPase activity
K6754_11615	COG3710	Transcriptional regulator
K6754_11635	COG0622	Phosphoesterase
K6754_11665	COG1090	epimerase
K6754_11670	COG0300	oxidoreductase activity
K6754_11675	COG3118	belongs to the thioredoxin family
K6754_11685	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
K6754_11695	COG1215	transferase activity, transferring glycosyl groups
K6754_11700	COG1192	Involved in chromosome partitioning
K6754_11720	COG2194	sulfuric ester hydrolase activity
K6754_11725	COG0330	HflC and HflK could
K6754_11745	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K6754_11750	COG3115	cell septum assembly
K6754_11755	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
K6754_11760	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6754_11765	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6754_11770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K6754_11775	COG2190	(PTS) system
K6754_11780	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6754_11785	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6754_11790	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6754_11795	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6754_11805	COG1705	Flagellar rod assembly protein muramidase FlgJ
K6754_11805	COG3951	Flagellar rod assembly protein muramidase FlgJ
K6754_11810	COG1706	bacterial-type flagellum-dependent cell motility
K6754_11815	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K6754_11825	COG4787	bacterial-type flagellum-dependent cell motility
K6754_11830	COG1749	Flagellar hook protein flgE
K6754_11840	COG1558	bacterial-type flagellum-dependent cell motility
K6754_11845	COG1815	bacterial-type flagellum-dependent cell motility
K6754_11850	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K6754_11855	COG0784	Response regulator, receiver
K6754_11855	COG0835	chemotaxis
K6754_11910	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K6754_11920	COG2217	Heavy metal translocating P-type atpase
K6754_11920	COG2608	mercury ion transmembrane transporter activity
K6754_11960	COG2840	Smr protein MutS2
K6754_11965	COG1187	pseudouridine synthase activity
K6754_11970	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K6754_11975	COG0737	Belongs to the 5'-nucleotidase family
K6754_11980	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K6754_11985	COG2912	Transglutaminase-like superfamily
K6754_11990	COG3094	Invasion gene expression up-regulator, SirB
K6754_11995	COG2890	protein-(glutamine-N5) methyltransferase activity
K6754_12005	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K6754_12010	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K6754_12015	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K6754_12020	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K6754_12025	COG0193	aminoacyl-tRNA hydrolase activity
K6754_12030	COG0012	GTP binding
K6754_12135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6754_12140	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K6754_12145	COG1702	phosphate starvation-inducible protein PhoH
K6754_12150	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K6754_12155	COG4535	Mg2 and Co2 transporter CorC
K6754_12160	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K6754_12165	COG2888	peptidyl-tyrosine sulfation
K6754_12170	COG0495	leucyl-tRNA aminoacylation
K6754_12175	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
K6754_12180	COG1466	dna polymerase III delta subunit
K6754_12185	COG0799	negative regulation of ribosome biogenesis
K6754_12190	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K6754_12195	COG0768	penicillin binding
K6754_12200	COG0772	Belongs to the SEDS family
K6754_12205	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K6754_12210	COG1686	Belongs to the peptidase S11 family
K6754_12220	COG0321	lipoyl(octanoyl) transferase activity
K6754_12225	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K6754_12230	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K6754_12235	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6754_12250	COG0366	Alpha amylase catalytic
K6754_12255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6754_12255	COG1263	PTS System
K6754_12265	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K6754_12270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K6754_12275	COG2011	ABC-type metal ion transport system permease component
K6754_12280	COG1464	Belongs to the NlpA lipoprotein family
K6754_12285	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
K6754_12295	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K6754_12295	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K6754_12310	COG1611	Belongs to the LOG family
K6754_12315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6754_12325	COG2363	Small membrane protein
K6754_12335	COG0583	DNA-binding transcription factor activity
K6754_12340	COG0301	tRNA thio-modification
K6754_12340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6754_12350	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K6754_12355	COG1722	exodeoxyribonuclease VII activity
K6754_12360	COG0142	geranyltranstransferase activity
K6754_12365	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K6754_12370	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K6754_12375	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K6754_12385	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K6754_12400	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6754_12400	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6754_12405	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K6754_12410	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K6754_12415	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K6754_12425	COG1073	alpha beta
K6754_12430	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K6754_12435	COG2252	PERMEase
K6754_12440	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6754_12470	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K6754_12470	COG0047	phosphoribosylformylglycinamidine synthase activity
K6754_12475	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K6754_12485	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K6754_12515	COG0484	heat shock protein binding
K6754_12525	COG1301	dicarboxylic acid transport
K6754_12530	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K6754_12535	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K6754_12545	COG0497	DNA recombination
K6754_12555	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6754_12560	COG2914	Belongs to the UPF0125 (RnfH) family
K6754_12565	COG2867	negative regulation of translational initiation
K6754_12570	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K6754_12590	COG0583	DNA-binding transcription factor activity
K6754_12595	COG3153	acetyltransferase
K6754_12595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6754_12615	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K6754_12620	COG2873	o-acetylhomoserine
K6754_12635	COG1115	amino acid carrier protein
K6754_12640	COG1584	GPR1 FUN34 yaaH family protein
K6754_12655	COG0519	Catalyzes the synthesis of GMP from XMP
K6754_12655	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K6754_12660	COG0517	IMP dehydrogenase activity
K6754_12660	COG0516	GMP reductase activity
K6754_12680	COG1160	GTP binding
K6754_12685	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6754_12690	COG2976	Protein conserved in bacteria
K6754_12695	COG0124	histidyl-tRNA synthetase
K6754_12700	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K6754_12715	COG0105	UTP biosynthetic process
K6754_12725	COG2975	iron-sulfur cluster assembly
K6754_12730	COG0633	Ferredoxin
K6754_12735	COG0443	Heat shock 70 kDa protein
K6754_12750	COG0822	iron-sulfur transferase activity
K6754_12755	COG1104	cysteine desulfurase activity
K6754_12765	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
K6754_12770	COG0483	inositol monophosphate 1-phosphatase activity
K6754_12775	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6754_12780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6754_12785	COG1862	Preprotein translocase
K6754_12795	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K6754_12805	COG0517	IMP dehydrogenase activity
K6754_12815	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K6754_12820	COG0583	DNA-binding transcription factor activity
K6754_12825	COG0450	alkyl hydroperoxide reductase
K6754_12830	COG3142	Participates in the control of copper homeostasis
K6754_12840	COG0704	Plays a role in the regulation of phosphate uptake
K6754_12845	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K6754_12850	COG0581	inorganic phosphate transmembrane transporter activity
K6754_12855	COG0573	inorganic phosphate transmembrane transporter activity
K6754_12860	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K6754_12865	COG0248	Ppx GppA phosphatase
K6754_12875	COG5002	protein histidine kinase activity
K6754_12880	COG0745	RESPONSE REGULATOR receiver
K6754_12885	COG2974	May be involved in recombination
K6754_12890	COG0826	peptidase U32
K6754_12895	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K6754_12950	COG0542	response to heat
K6754_12960	COG0564	pseudouridine synthase activity
K6754_12965	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6754_12975	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K6754_12980	COG0077	Prephenate dehydratase
K6754_12980	COG1605	Chorismate mutase
K6754_12985	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
K6754_12990	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
K6754_13000	COG0488	(ABC) transporter
K6754_13010	COG0739	heme binding
K6754_13015	COG1605	Chorismate mutase
K6754_13015	COG0287	Prephenate dehydrogenase
K6754_13020	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K6754_13025	COG1472	Belongs to the glycosyl hydrolase 3 family
K6754_13030	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K6754_13050	COG1966	Carbon starvation protein
K6754_13055	COG3275	phosphorelay sensor kinase activity
K6754_13060	COG3279	Response regulator of the LytR AlgR family
K6754_13070	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K6754_13075	COG1047	Peptidyl-prolyl cis-trans
K6754_13090	COG0196	riboflavin kinase activity
K6754_13095	COG0728	peptidoglycan biosynthetic process
K6754_13100	COG0268	Binds directly to 16S ribosomal RNA
K6754_13105	COG0640	Transcriptional regulator
K6754_13110	COG0583	DNA-binding transcription factor activity
K6754_13115	COG1283	sodium-dependent phosphate transmembrane transporter activity
K6754_13125	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K6754_13130	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K6754_13135	COG0730	response to heat
K6754_13160	COG0667	Aldo Keto reductase
K6754_13170	COG2204	response regulator
K6754_13185	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K6754_13190	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K6754_13195	COG4974	Belongs to the 'phage' integrase family
K6754_13200	COG0716	FMN binding
K6754_13210	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K6754_13215	COG0513	Belongs to the DEAD box helicase family
K6754_13220	COG3022	response to hydroperoxide
K6754_13225	COG1115	amino acid carrier protein
K6754_13240	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K6754_13245	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K6754_13250	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
K6754_13260	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K6754_13265	COG0083	homoserine kinase activity
K6754_13285	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K6754_13295	COG0745	RESPONSE REGULATOR receiver
K6754_13305	COG2198	Histidine kinase
K6754_13305	COG5002	protein histidine kinase activity
K6754_13305	COG0784	Response regulator, receiver
K6754_13310	COG2203	Gaf domain
K6754_13310	COG3706	GGDEF domain
K6754_13310	COG4251	negative regulation of phosphorylation
K6754_13310	COG5001	Diguanylate cyclase
K6754_13315	COG1242	4 iron, 4 sulfur cluster binding
K6754_13320	COG0069	glutamate synthase activity
K6754_13320	COG0070	glutamate synthase
K6754_13320	COG0067	glutamate synthase
K6754_13330	COG0070	glutamate synthase
K6754_13330	COG0067	glutamate synthase
K6754_13330	COG0069	glutamate synthase activity
K6754_13335	COG0493	'glutamate synthase
K6754_13345	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K6754_13360	COG2860	membrane
K6754_13365	COG0583	DNA-binding transcription factor activity
K6754_13370	COG0730	response to heat
K6754_13385	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K6754_13390	COG0505	Belongs to the CarA family
K6754_13400	COG0494	nUDIX hydrolase
K6754_13405	COG0653	protein targeting
K6754_13415	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K6754_13420	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K6754_13425	COG0849	cell division
K6754_13430	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K6754_13445	COG0772	Belongs to the SEDS family
K6754_13450	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K6754_13455	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6754_13460	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K6754_13465	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K6754_13470	COG0768	penicillin binding
K6754_13475	COG3116	cell division
K6754_13490	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K6754_13505	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K6754_13510	COG2823	Periplasmic or secreted lipoprotein
K6754_13515	COG2969	positive regulation of protein catabolic process
K6754_13520	COG0625	glutathione transferase activity
K6754_13525	COG2857	Cytochrome c1
K6754_13530	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K6754_13535	COG0723	plastoquinol--plastocyanin reductase activity
K6754_13540	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K6754_13550	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K6754_13555	COG3105	Protein conserved in bacteria
K6754_13565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6754_13570	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K6754_13580	COG3150	esterase
K6754_13590	COG3151	Protein conserved in bacteria
K6754_13595	COG0494	nUDIX hydrolase
K6754_13600	COG1538	Outer membrane efflux protein
K6754_13605	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K6754_13605	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K6754_13610	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K6754_13625	COG3025	triphosphatase activity
K6754_13630	COG1392	Phosphate transport regulator
K6754_13635	COG0306	phosphate transporter
K6754_13640	COG4991	sh3 domain protein
K6754_13645	COG0405	Gamma-glutamyltransferase
K6754_13655	COG3267	Type II secretory pathway component ExeA
K6754_13655	COG3409	Peptidoglycan-binding domain 1 protein
K6754_13665	COG1968	undecaprenyl-diphosphatase activity
K6754_13670	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K6754_13675	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K6754_13680	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K6754_13685	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K6754_13690	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K6754_13695	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K6754_13700	COG1610	YqeY-like protein
K6754_13705	COG0358	DNA primase activity
K6754_13830	COG2213	PTS system mannitol-specific
K6754_13830	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6754_13840	COG3722	fumarate hydratase activity
K6754_13855	COG1461	Dihydroxyacetone kinase
K6754_13860	COG2376	Dihydroxyacetone kinase
K6754_13870	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K6754_13875	COG1349	DNA-binding transcription factor activity
K6754_13880	COG0469	pyruvate kinase activity
K6754_13895	COG0440	acetolactate synthase activity
K6754_13900	COG0028	Belongs to the TPP enzyme family
K6754_13905	COG1022	Amp-dependent synthetase and ligase
K6754_13910	COG0583	DNA-binding transcription factor activity
K6754_13930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K6754_13935	COG0473	3-isopropylmalate dehydrogenase activity
K6754_13955	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K6754_13960	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K6754_13965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6754_13970	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K6754_13975	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K6754_13980	COG2967	ApaG domain
K6754_13985	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K6754_14000	COG2966	Psort location CytoplasmicMembrane, score
K6754_14005	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K6754_14015	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K6754_14020	COG0142	geranyltranstransferase activity
K6754_14040	COG2358	TRAP transporter, solute receptor (TAXI family
K6754_14055	COG1902	pentaerythritol trinitrate reductase activity
K6754_14060	COG0583	DNA-binding transcription factor activity
K6754_14065	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K6754_14070	COG1178	ABC-type Fe3 transport system permease component
K6754_14075	COG4143	(ABC) transporter
K6754_14080	COG0163	prenyltransferase activity
K6754_14085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K6754_14090	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K6754_14095	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K6754_14105	COG2105	PFAM AIG2 family protein
K6754_14110	COG2911	Protein conserved in bacteria
K6754_14115	COG0729	surface antigen
K6754_14120	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6754_14130	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K6754_14145	COG4181	ATPase activity
K6754_14165	COG0529	Catalyzes the synthesis of activated sulfate
K6754_14170	COG3273	potassium ion transport
K6754_14170	COG0471	metal ion transport
K6754_14175	COG2895	sulfate adenylyltransferase (ATP) activity
K6754_14180	COG0175	sulfate reduction
K6754_14185	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K6754_14185	COG1648	precorrin-2 dehydrogenase activity
K6754_14200	COG0513	Belongs to the DEAD box helicase family
K6754_14205	COG2153	protein acetylation
K6754_14215	COG0545	Peptidyl-prolyl cis-trans isomerase
K6754_14225	COG0203	ribosomal protein L17
K6754_14230	COG0202	RNA polymerase activity
K6754_14240	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K6754_14245	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K6754_14250	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K6754_14255	COG0201	protein transport
K6754_14260	COG0200	Binds to the 23S rRNA
K6754_14265	COG1841	ribosomal large subunit assembly
K6754_14280	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K6754_14285	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K6754_14295	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K6754_14300	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K6754_14310	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K6754_14315	COG0255	Belongs to the universal ribosomal protein uL29 family
K6754_14325	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K6754_14330	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K6754_14335	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K6754_14340	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K6754_14350	COG0088	Forms part of the polypeptide exit tunnel
K6754_14355	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K6754_14365	COG0254	rRNA binding
K6754_14370	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K6754_14375	COG1609	Transcriptional regulator
K6754_14385	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K6754_14390	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K6754_14395	COG1575	Belongs to the MenA family. Type 1 subfamily
K6754_14400	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K6754_14410	COG1494	fructose-1,6-bisphosphatase
K6754_14440	COG0149	triose-phosphate isomerase activity
K6754_14480	COG0438	transferase activity, transferring glycosyl groups
K6754_14485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6754_14490	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K6754_14495	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6754_14520	COG2244	polysaccharide biosynthetic process
K6754_14535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K6754_14560	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K6754_14600	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6754_14610	COG1560	Kdo2-lipid A biosynthetic process
K6754_14620	COG0859	PFAM glycosyl transferase family 9
K6754_14625	COG1519	Transferase
K6754_14630	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K6754_14670	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K6754_14680	COG3642	lipopolysaccharide core region biosynthetic process
K6754_14685	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K6754_14690	COG0859	PFAM glycosyl transferase family 9
K6754_14695	COG0463	Glycosyl transferase, family 2
K6754_14710	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K6754_14735	COG2003	Belongs to the UPF0758 family
K6754_14745	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K6754_14750	COG1309	transcriptional regulator
K6754_14755	COG1560	Kdo2-lipid A biosynthetic process
K6754_14760	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K6754_14765	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K6754_14770	COG1561	YicC-like family, N-terminal region
K6754_14895	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K6754_14905	COG4608	Belongs to the ABC transporter superfamily
K6754_14910	COG0444	Belongs to the ABC transporter superfamily
K6754_14915	COG0747	negative chemotaxis
K6754_14920	COG4239	(ABC) transporter, permease
K6754_14925	COG4174	ABC transporter (Permease)
K6754_14945	COG0811	peptide transport
K6754_14950	COG0848	biopolymer transport protein
K6754_14965	COG0194	GDP metabolic process
K6754_14970	COG1758	RNA polymerase activity
K6754_14975	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K6754_14980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6754_14985	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K6754_14990	COG2233	PERMEase
K6754_15010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6754_15020	COG2183	response to ionizing radiation
K6754_15035	COG1040	competence protein
K6754_15045	COG0494	nUDIX hydrolase
K6754_15050	COG1218	3'(2'),5'-bisphosphate nucleotidase
K6754_15060	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K6754_15065	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K6754_15070	COG3156	type II secretion system protein K
K6754_15075	COG4795	General secretion pathway protein
K6754_15080	COG2165	general secretion pathway protein
K6754_15085	COG2165	general secretion pathway protein
K6754_15090	COG2165	general secretion pathway protein
K6754_15095	COG1459	type II secretion system
K6754_15100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K6754_15110	COG3031	protein transport across the cell outer membrane
K6754_15115	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K6754_15120	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K6754_15125	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K6754_15135	COG0456	acetyltransferase
K6754_15140	COG1490	D-aminoacyl-tRNA deacylase activity
K6754_15145	COG1295	ribonuclease BN
K6754_15155	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K6754_15160	COG1217	gtp-binding protein TYPA
K6754_15165	COG0174	glutamine synthetase
K6754_15175	COG3852	Histidine kinase
K6754_15180	COG2204	response regulator
K6754_15190	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K6754_15220	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K6754_15225	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6754_15225	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6754_15230	COG0456	acetyltransferase
K6754_15240	COG0084	hydrolase, TatD family'
K6754_15245	COG0805	protein transport
K6754_15250	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K6754_15260	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K6754_15265	COG3165	ubiquinone biosynthetic process from chorismate
K6754_15270	COG2226	methyltransferase
K6754_15275	COG1322	Protein conserved in bacteria
K6754_15290	COG0628	permease
K6754_15320	COG1597	lipid kinase activity
K6754_15350	COG2081	HI0933 family
K6754_15360	COG1528	Iron-storage protein
K6754_15365	COG0589	response to stress
K6754_15380	COG0742	ribosomal rna small subunit methyltransferase
K6754_15385	COG5001	Diguanylate cyclase
K6754_15385	COG5002	protein histidine kinase activity
K6754_15390	COG1522	sequence-specific DNA binding
K6754_15400	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K6754_15405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6754_15410	COG0583	DNA-binding transcription factor activity
K6754_15415	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K6754_15420	COG0800	Aldolase
K6754_15425	COG2610	gluconate transmembrane transporter activity
K6754_15430	COG3265	gluconokinase activity
K6754_15435	COG0129	dihydroxy-acid dehydratase activity
K6754_15450	COG0583	DNA-binding transcription factor activity
K6754_15455	COG1609	Transcriptional regulator
K6754_15495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6754_15500	COG0601	transmembrane transport
K6754_15505	COG4166	transmembrane transport
K6754_15560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6754_15565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6754_15570	COG2960	long-chain fatty acid transporting porin activity
K6754_15575	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K6754_15580	COG0583	DNA-binding transcription factor activity
K6754_15615	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K6754_15635	COG0009	L-threonylcarbamoyladenylate synthase
K6754_15640	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K6754_15645	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K6754_15650	COG0551	DNA topoisomerase type I activity
K6754_15655	COG2922	Belongs to the Smg family
K6754_15660	COG0758	DNA mediated transformation
K6754_15670	COG0242	peptide deformylase activity
K6754_15675	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K6754_15680	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K6754_15680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K6754_15685	COG0569	domain protein
K6754_15690	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6754_15700	COG1272	protein, Hemolysin III
K6754_15705	COG4326	sporulation control protein
K6754_15715	COG3084	Protein conserved in bacteria
K6754_15725	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K6754_15730	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K6754_15735	COG0204	Acyl-transferase
K6754_15745	COG0606	chelatase, subunit chli
K6754_15755	COG3978	acetolactate synthase activity
K6754_15760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6754_15765	COG0129	dihydroxy-acid dehydratase activity
K6754_15775	COG0583	DNA-binding transcription factor activity
K6754_15780	COG2814	Major facilitator Superfamily
K6754_15790	COG0765	amino acid transport
K6754_15800	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K6754_15805	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K6754_15810	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K6754_15815	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K6754_15820	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K6754_15825	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K6754_15835	COG0356	it plays a direct role in the translocation of protons across the membrane
K6754_15840	COG3312	ion transport
K6754_15845	COG1475	DNA binding
K6754_15850	COG1192	Involved in chromosome partitioning
K6754_15855	COG0357	Ribosomal RNA small subunit methyltransferase G
K6754_15860	COG0445	tRNA wobble uridine modification
K6754_15865	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K6754_15880	COG1395	domain, Protein
K6754_15925	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
K6754_15960	COG4974	Belongs to the 'phage' integrase family
K6754_15970	COG0706	membrane insertase activity
K6754_15980	COG0594	ribonuclease P activity
K6754_15990	COG1126	abc transporter atp-binding protein
K6754_16055	COG3097	Belongs to the UPF0267 family
K6754_16060	COG1309	transcriptional regulator
K6754_16065	COG2130	NADP-dependent
K6754_16075	COG0753	catalase activity
K6754_16080	COG2084	Dehydrogenase
K6754_16110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6754_16115	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
K6754_16125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6754_16130	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6754_16135	COG1012	belongs to the aldehyde dehydrogenase family
K6754_16145	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6754_16150	COG0583	DNA-binding transcription factor activity
K6754_16155	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6754_16160	COG0569	domain protein
K6754_16170	COG2205	protein histidine kinase activity
K6754_16170	COG2205	protein histidine kinase activity
K6754_16175	COG1132	(ABC) transporter
K6754_16180	COG4774	siderophore transport
K6754_16185	COG1120	ATPase activity
K6754_16190	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K6754_16225	COG2197	response regulator
K6754_16240	COG0714	Associated with various cellular activities
K6754_16260	COG2304	oxidoreductase activity
K6754_16275	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K6754_16280	COG0581	inorganic phosphate transmembrane transporter activity
K6754_16285	COG0573	inorganic phosphate transmembrane transporter activity
K6754_16315	COG4771	TonB-dependent receptor
K6754_16320	COG1770	oligopeptidase
K6754_16325	COG0513	Belongs to the DEAD box helicase family
K6754_16335	COG1376	ErfK ybiS ycfS ynhG family protein
K6754_16335	COG1388	LysM domain
K6754_16340	COG0415	Belongs to the DNA photolyase family
K6754_16345	COG0789	Transcriptional regulator
K6754_16350	COG3272	Protein of unknown function (DUF1722)
K6754_16355	COG0813	purine-nucleoside phosphorylase activity
K6754_16380	COG1566	PFAM secretion protein HlyD family protein
K6754_16385	COG4720	Psort location CytoplasmicMembrane, score
K6754_16390	COG1122	ATPase activity
K6754_16410	COG0348	domain, Protein
K6754_16415	COG0437	4 iron, 4 sulfur cluster binding
K6754_16420	COG1247	-acetyltransferase
K6754_16440	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6754_16450	COG1067	ATP-dependent peptidase activity
K6754_16460	COG4172	Belongs to the ABC transporter superfamily
K6754_16465	COG1505	serine-type exopeptidase activity
K6754_16470	COG0583	DNA-binding transcription factor activity
K6754_16475	COG1620	l-lactate permease
K6754_16480	COG1304	FMN binding
K6754_16490	COG0668	transmembrane transport
K6754_16525	COG1063	alcohol dehydrogenase
K6754_16530	COG0156	8-amino-7-oxononanoate synthase activity
K6754_16535	COG3300	MHYT domain
K6754_16535	COG5001	Diguanylate cyclase
K6754_16560	COG0745	RESPONSE REGULATOR receiver
K6754_16585	COG0346	lactoylglutathione lyase activity
K6754_16645	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K6754_16685	COG1987	bacterial-type flagellum assembly
K6754_16695	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K6754_16710	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6754_16720	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K6754_16725	COG1516	flagellar protein fliS
K6754_16740	COG1580	Controls the rotational direction of flagella during chemotaxis
K6754_16745	COG1191	sigma factor activity
K6754_16750	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K6754_16755	COG1360	Flagellar Motor Protein
K6754_16785	COG1882	Formate acetyltransferase
K6754_16790	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K6754_16795	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K6754_16805	COG4452	Inner membrane protein CreD
K6754_16810	COG2205	protein histidine kinase activity
K6754_16815	COG0745	RESPONSE REGULATOR receiver
K6754_16825	COG0454	-acetyltransferase
K6754_16835	COG2814	Major facilitator Superfamily
K6754_16875	COG0628	permease
K6754_16880	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K6754_16900	COG4628	conserved protein (DUF2132)
K6754_16905	COG0583	DNA-binding transcription factor activity
K6754_16930	COG1686	Belongs to the peptidase S11 family
K6754_16940	COG1054	Belongs to the UPF0176 family
K6754_16950	COG0415	Belongs to the DNA photolyase family
K6754_16955	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K6754_16960	COG3397	chitin binding
K6754_16965	COG4667	esterase of the alpha-beta hydrolase superfamily
K6754_16970	COG2095	MarC family integral membrane protein
K6754_16985	COG1596	polysaccharide export
K6754_16990	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K6754_17010	COG0583	DNA-binding transcription factor activity
K6754_17020	COG1301	dicarboxylic acid transport
K6754_17025	COG3339	Conserved Protein
K6754_17030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6754_17035	COG0700	Nucleoside recognition
K6754_17040	COG3366	ferrous iron transmembrane transporter activity
K6754_17055	COG0366	Alpha amylase catalytic
K6754_17060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6754_17065	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K6754_17070	COG1640	4-alpha-glucanotransferase
K6754_17075	COG0058	SHG alpha-glucan phosphorylase activity
K6754_17080	COG2909	trisaccharide binding
K6754_17095	COG1999	signal sequence binding
K6754_17100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6754_17100	COG1263	PTS System
K6754_17105	COG1162	GTPase activity
K6754_17110	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
K6754_17115	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K6754_17125	COG0531	amino acid
K6754_17130	COG1982	Orn Lys Arg decarboxylase major
K6754_17150	COG2356	endonuclease I
K6754_17170	COG4580	involved in the transport of maltose and maltodextrins
K6754_17180	COG1760	l-serine dehydratase
K6754_17220	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K6754_17230	COG1609	Transcriptional regulator
K6754_17235	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K6754_17245	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K6754_17245	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K6754_17260	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6754_17265	COG1609	Transcriptional regulator
K6754_17275	COG2814	Major facilitator Superfamily
K6754_17290	COG0739	heme binding
K6754_17300	COG0612	Peptidase, M16
K6754_17305	COG0840	transmembrane signaling receptor activity
K6754_17310	COG1120	ATPase activity
K6754_17315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6754_17320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6754_17325	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K6754_17330	COG4772	TonB-dependent receptor
K6754_17355	COG4264	IucA IucC family
K6754_17360	COG0019	diaminopimelate decarboxylase activity
K6754_17365	COG1653	transport
K6754_17390	COG0826	peptidase U32
K6754_17400	COG1136	(ABC) transporter
K6754_17405	COG0577	efflux transmembrane transporter activity
K6754_17450	COG1764	response to oxidative stress
K6754_17455	COG1846	Transcriptional regulator
K6754_17465	COG3634	alkyl hydroperoxide reductase activity
K6754_17510	COG2258	MOSC domain
K6754_17515	COG0513	Belongs to the DEAD box helicase family
K6754_17525	COG1132	(ABC) transporter
K6754_17560	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6754_17585	COG0259	pyridoxamine-phosphate oxidase activity
K6754_17630	COG0655	NAD(P)H dehydrogenase (quinone) activity
K6754_17635	COG4166	transmembrane transport
K6754_17650	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K6754_17655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6754_17655	COG1263	PTS System
K6754_17660	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6754_17665	COG3340	Belongs to the peptidase S51 family
K6754_17685	COG1444	tRNA N-acetyltransferase activity
K6754_17710	COG4608	Belongs to the ABC transporter superfamily
K6754_17715	COG0444	Belongs to the ABC transporter superfamily
K6754_17725	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
K6754_17725	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6754_17750	COG0772	Belongs to the SEDS family
K6754_17760	COG1136	(ABC) transporter
K6754_17780	COG3275	phosphorelay sensor kinase activity
K6754_17785	COG3279	Response regulator of the LytR AlgR family
K6754_17795	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K6754_17815	COG0786	glutamate:sodium symporter activity
K6754_17825	COG1131	(ABC) transporter
K6754_17830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6754_17835	COG0786	glutamate:sodium symporter activity
K6754_17845	COG0363	glucosamine-6-phosphate deaminase activity
K6754_17865	COG1741	Belongs to the pirin family
K6754_17870	COG2259	Doxx family
K6754_17880	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K6754_17880	COG2169	Transcriptional regulator
K6754_17885	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K6754_17895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6754_17920	COG0596	Alpha beta hydrolase
K6754_17935	COG3123	guanosine phosphorylase activity
K6754_17950	COG0534	Mate efflux family protein
K6754_17955	COG0564	pseudouridine synthase activity
K6754_17970	COG0583	DNA-binding transcription factor activity
K6754_17975	COG0561	phosphatase activity
K6754_17985	COG2199	diguanylate cyclase activity
K6754_18000	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K6754_18005	COG2162	N-hydroxyarylamine O-acetyltransferase activity
K6754_18010	COG0583	DNA-binding transcription factor activity
K6754_18015	COG2375	cellular response to nickel ion
K6754_18045	COG1357	PFAM Pentapeptide repeats (8 copies)
K6754_18050	COG3047	cAMP biosynthetic process
K6754_18110	COG3835	regulator
K6754_18115	COG2610	gluconate transmembrane transporter activity
K6754_18120	COG1929	Belongs to the glycerate kinase type-1 family
K6754_18125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6754_18145	COG0456	acetyltransferase
K6754_18160	COG1028	Short-chain dehydrogenase reductase Sdr
K6754_18165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6754_18170	COG3005	denitrification pathway
K6754_18175	COG0243	molybdopterin cofactor binding
K6754_18195	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K6754_18200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K6754_18205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6754_18210	COG1116	anion transmembrane transporter activity
K6754_18215	COG0351	phosphomethylpyrimidine kinase
K6754_18220	COG0312	modulator of DNA gyrase
K6754_18225	COG0312	modulator of DNA gyrase
K6754_18230	COG1901	pseudouridine methyltransferase
K6754_18290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6754_18300	COG0584	glycerophosphoryl diester phosphodiesterase
K6754_18305	COG0745	RESPONSE REGULATOR receiver
K6754_18325	COG0811	peptide transport
K6754_18330	COG0811	peptide transport
K6754_18335	COG0848	biopolymer transport protein
K6754_18375	COG0803	Belongs to the bacterial solute-binding protein 9 family
K6754_18380	COG1121	(ABC) transporter
K6754_18385	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K6754_18400	COG1770	oligopeptidase
K6754_18405	COG2814	Major facilitator Superfamily
K6754_18410	COG0010	Belongs to the arginase family
K6754_18415	COG1166	arginine decarboxylase activity
K6754_18425	COG0189	ligase activity
K6754_18425	COG4067	protein conserved in archaea
K6754_18430	COG0189	ligase activity
K6754_18450	COG0583	DNA-binding transcription factor activity
K6754_18480	COG3706	GGDEF domain
K6754_18500	COG0579	oxidoreductase
K6754_18520	COG1294	oxidase, subunit
K6754_18525	COG1271	oxidase subunit
K6754_18535	COG3033	Beta-eliminating lyase
K6754_18555	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6754_18570	COG3706	GGDEF domain
K6754_18585	COG3706	GGDEF domain
K6754_18590	COG0415	Belongs to the DNA photolyase family
K6754_18595	COG3046	protein related to deoxyribodipyrimidine photolyase
K6754_18610	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6754_18610	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6754_18615	COG1765	OsmC-like protein
K6754_18620	COG0110	maltose O-acetyltransferase activity
K6754_18660	COG1011	Hydrolase
K6754_18675	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K6754_18685	COG2067	long-chain fatty acid transport protein
K6754_18690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6754_18695	COG1136	(ABC) transporter
K6754_18695	COG0577	efflux transmembrane transporter activity
K6754_18710	COG1309	transcriptional regulator
K6754_18715	COG3240	lipase activity
K6754_18735	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K6754_18745	COG1840	ABC-type Fe3 transport system, periplasmic component
K6754_18750	COG3842	ATPase activity
K6754_18775	COG2990	Protein conserved in bacteria
K6754_18785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6754_18790	COG2866	Carboxypeptidase
K6754_18800	COG0583	DNA-binding transcription factor activity
K6754_18815	COG1760	l-serine dehydratase
K6754_18835	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K6754_18840	COG0741	lytic transglycosylase activity
K6754_18860	COG1815	bacterial-type flagellum-dependent cell motility
K6754_18865	COG1558	bacterial-type flagellum-dependent cell motility
K6754_18880	COG4787	bacterial-type flagellum-dependent cell motility
K6754_18885	COG4786	Flagellar basal body rod
K6754_18890	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K6754_18895	COG1706	bacterial-type flagellum-dependent cell motility
K6754_18905	COG1256	bacterial-type flagellum assembly
K6754_18905	COG4786	Flagellar basal body rod
K6754_18930	COG1304	FMN binding
K6754_18945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6754_18950	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K6754_18955	COG0459	protein refolding
K6754_18965	COG1280	lysine exporter protein (LysE YggA)
K6754_18985	COG1309	transcriptional regulator
K6754_18995	COG4303	Ethanolamine ammonia lyase large subunit
K6754_19000	COG4302	ethanolamine ammonia-lyase activity
K6754_19005	COG0531	amino acid
K6754_19010	COG2070	2-Nitropropane dioxygenase
K6754_19020	COG1349	DNA-binding transcription factor activity
K6754_19035	COG1335	isochorismatase
K6754_19045	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K6754_19070	COG0583	DNA-binding transcription factor activity
K6754_19085	COG3713	MltA-interacting MipA family protein
K6754_19090	COG3015	lipoprotein NlpE involved in copper resistance
K6754_19095	COG4175	Glycine betaine
K6754_19095	COG3448	diguanylate cyclase activity
K6754_19100	COG4176	ABC-type proline glycine betaine transport system permease component
K6754_19105	COG1342	Belongs to the UPF0251 family
K6754_19135	COG4948	Mandelate Racemase Muconate Lactonizing
K6754_19145	COG0583	DNA-binding transcription factor activity
K6754_19175	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K6754_19180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6754_19205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6754_19225	COG3842	ATPase activity
K6754_19255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6754_19280	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K6754_19285	COG2197	response regulator
K6754_19300	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K6754_19305	COG0252	asparaginase activity
K6754_19310	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K6754_19315	COG0583	DNA-binding transcription factor activity
K6754_19330	COG3122	Protein conserved in bacteria
K6754_19335	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K6754_19340	COG1012	belongs to the aldehyde dehydrogenase family
K6754_19345	COG1522	sequence-specific DNA binding
K6754_19350	COG3608	succinylglutamate desuccinylase aspartoacylase
K6754_19355	COG0006	proline dipeptidase activity
K6754_19360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6754_19370	COG1028	Short-chain dehydrogenase reductase Sdr
K6754_19380	COG1063	alcohol dehydrogenase
K6754_19385	COG1902	pentaerythritol trinitrate reductase activity
K6754_19400	COG0583	DNA-binding transcription factor activity
K6754_19410	COG0513	Belongs to the DEAD box helicase family
K6754_19430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6754_19435	COG2207	Transcriptional regulator
K6754_19435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6754_19440	COG0583	DNA-binding transcription factor activity
K6754_19445	COG0300	oxidoreductase activity
K6754_19460	COG3746	phosphate-selective porin O and P
K6754_19475	COG1028	Short-chain dehydrogenase reductase Sdr
K6754_19480	COG1404	Belongs to the peptidase S8 family
K6754_19490	COG0583	DNA-binding transcription factor activity
K6754_19495	COG4771	TonB-dependent receptor
K6754_19515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6754_19515	COG1263	PTS System
K6754_19520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6754_19525	COG1621	beta-fructofuranosidase activity
K6754_19530	COG0625	glutathione transferase activity
K6754_19535	COG1686	Belongs to the peptidase S11 family
K6754_19545	COG0678	peroxiredoxin activity
K6754_19545	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K6754_19550	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K6754_19565	COG1278	Cold shock
K6754_19570	COG1741	Belongs to the pirin family
K6754_19575	COG4667	esterase of the alpha-beta hydrolase superfamily
K6754_19595	COG2194	sulfuric ester hydrolase activity
K6754_19600	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K6754_19610	COG2205	protein histidine kinase activity
K6754_19615	COG0745	RESPONSE REGULATOR receiver
K6754_19630	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K6754_19650	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6754_19660	COG2814	Major facilitator Superfamily
K6754_19670	COG1418	mRNA catabolic process
K6754_19675	COG0402	S-adenosylhomocysteine deaminase activity
K6754_19680	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K6754_19685	COG2239	Acts as a magnesium transporter
K6754_19690	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K6754_19695	COG1566	PFAM secretion protein HlyD family protein
K6754_19720	COG0745	RESPONSE REGULATOR receiver
K6754_19725	COG2205	protein histidine kinase activity
K6754_19740	COG0531	amino acid
K6754_19750	COG0583	DNA-binding transcription factor activity
K6754_19775	COG5002	protein histidine kinase activity
K6754_19775	COG0784	Response regulator, receiver
K6754_19775	COG2205	protein histidine kinase activity
K6754_19795	COG3132	Protein of unknown function, DUF480
K6754_19800	COG2827	Endonuclease containing a URI domain
K6754_19805	COG1879	ABC-type sugar transport system periplasmic component
K6754_19810	COG0784	Response regulator, receiver
K6754_19810	COG2205	protein histidine kinase activity
K6754_19815	COG1846	Transcriptional regulator
K6754_19865	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6754_19870	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6754_19880	COG1280	lysine exporter protein (LysE YggA)
K6754_19890	COG0183	Belongs to the thiolase family
K6754_19900	COG3243	poly(R)-hydroxyalkanoic acid synthase
K6754_19910	COG3005	denitrification pathway
K6754_19920	COG0243	molybdopterin cofactor binding
K6754_19930	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K6754_19935	COG3850	Histidine kinase
K6754_19940	COG2197	response regulator
K6754_19955	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6754_19975	COG0840	transmembrane signaling receptor activity
K6754_19985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6754_19995	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K6754_20000	COG2814	Major facilitator Superfamily
K6754_20010	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K6754_20015	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K6754_20025	COG2897	thiosulfate sulfurtransferase activity
K6754_20060	COG0038	chloride channel
K6754_20075	COG4989	oxidoreductase activity
K6754_20090	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K6754_20090	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K6754_20100	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K6754_20145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6754_20160	COG0739	heme binding
K6754_20200	COG3501	Rhs element vgr protein
K6754_20225	COG0515	serine threonine protein kinase
K6754_20260	COG1522	sequence-specific DNA binding
K6754_20320	COG2814	Major facilitator Superfamily
K6754_20330	COG0583	DNA-binding transcription factor activity
K6754_20335	COG4221	oxidoreductase activity
K6754_20340	COG0589	response to stress
K6754_20350	COG2111	Na H antiporter
K6754_20350	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K6754_20355	COG1006	Multisubunit Na H antiporter MnhC subunit
K6754_20360	COG0651	ATP synthesis coupled electron transport
K6754_20365	COG1863	multisubunit Na H antiporter MnhE subunit
K6754_20370	COG2212	antiporter activity
K6754_20375	COG1320	monovalent cation:proton antiporter activity
K6754_20380	COG2188	Transcriptional regulator
K6754_20385	COG1486	melibiose metabolic process
K6754_20390	COG1263	PTS System
K6754_20390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6754_20395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6754_20420	COG1022	Amp-dependent synthetase and ligase
K6754_20450	COG0500	methyltransferase
K6754_20465	COG3527	Alpha-acetolactate decarboxylase
K6754_20475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6754_20490	COG1294	oxidase, subunit
K6754_20495	COG1271	oxidase subunit
K6754_20500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6754_20505	COG0110	maltose O-acetyltransferase activity
K6754_20510	COG3264	Mechanosensitive ion channel
K6754_20510	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K6754_20525	COG4770	biotin carboxylase activity
K6754_20535	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K6754_20540	COG1960	acyl-CoA dehydrogenase activity
K6754_20550	COG0183	Belongs to the thiolase family
K6754_20560	COG1960	acyl-CoA dehydrogenase activity
K6754_20565	COG1024	Enoyl-CoA hydratase
K6754_20580	COG1028	Short-chain dehydrogenase reductase Sdr
K6754_20590	COG1309	transcriptional regulator
K6754_20595	COG1012	belongs to the aldehyde dehydrogenase family
K6754_20610	COG4176	ABC-type proline glycine betaine transport system permease component
K6754_20615	COG0517	IMP dehydrogenase activity
K6754_20615	COG4175	Glycine betaine
K6754_20630	COG0330	HflC and HflK could
K6754_20645	COG2205	protein histidine kinase activity
K6754_20645	COG0784	Response regulator, receiver
K6754_20655	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K6754_20710	COG5001	Diguanylate cyclase
K6754_20715	COG1869	D-ribose catabolic process
K6754_20720	COG1129	ABC transporter
K6754_20725	COG1172	Belongs to the binding-protein-dependent transport system permease family
K6754_20730	COG1879	ABC-type sugar transport system periplasmic component
K6754_20735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6754_20740	COG1609	Transcriptional regulator
K6754_20750	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
K6754_20760	COG4607	ABC-type enterochelin transport system periplasmic component
K6754_20765	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6754_20770	COG4605	iron ion homeostasis
K6754_20775	COG4604	ABC transporter, ATP-binding protein
K6754_20780	COG0789	Transcriptional regulator
K6754_20790	COG1629	transport
K6754_20790	COG4771	TonB-dependent receptor
K6754_20820	COG1289	transmembrane transporter activity
K6754_20825	COG0210	DNA helicase
K6754_20830	COG1803	Methylglyoxal synthase
K6754_20835	COG1879	ABC-type sugar transport system periplasmic component
K6754_20840	COG2198	Histidine kinase
K6754_20840	COG2205	protein histidine kinase activity
K6754_20840	COG0784	Response regulator, receiver
K6754_20855	COG0745	RESPONSE REGULATOR receiver
K6754_20860	COG3119	arylsulfatase activity
K6754_20870	COG3119	arylsulfatase activity
K6754_20875	COG0641	radical SAM
K6754_20880	COG0714	Associated with various cellular activities
K6754_20910	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6754_20915	COG0583	DNA-binding transcription factor activity
K6754_20920	COG1597	lipid kinase activity
K6754_20925	COG3111	PFAM Bacterial OB fold (BOF) protein
K6754_20950	COG3069	C4-dicarboxylate transmembrane transporter activity
K6754_20960	COG0456	acetyltransferase
K6754_20960	COG1214	PFAM Peptidase M22, glycoprotease
K6754_20980	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K6754_20990	COG3300	MHYT domain
K6754_20990	COG5001	Diguanylate cyclase
K6754_20995	COG2197	response regulator
K6754_21000	COG3706	GGDEF domain
K6754_21010	COG2197	response regulator
K6754_21015	COG0784	Response regulator, receiver
K6754_21015	COG0835	chemotaxis
K6754_21030	COG2962	Rard protein
K6754_21050	COG2076	Multidrug Resistance protein
K6754_21085	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K6754_21090	COG5642	Protein of unknown function (DUF2384)
K6754_21110	COG1902	pentaerythritol trinitrate reductase activity
K6754_21115	COG0346	lactoylglutathione lyase activity
K6754_21135	COG2239	Acts as a magnesium transporter
K6754_21160	COG0242	peptide deformylase activity
K6754_21200	COG2176	DNA-directed DNA polymerase activity
K6754_21230	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K6754_21235	COG0697	spore germination
K6754_21240	COG0583	DNA-binding transcription factor activity
K6754_21245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6754_21250	COG0346	lactoylglutathione lyase activity
K6754_21260	COG0509	glycine decarboxylation via glycine cleavage system
K6754_21265	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K6754_21275	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K6754_21305	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
K6754_21305	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K6754_21305	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K6754_21310	COG1105	Belongs to the carbohydrate kinase PfkB family
K6754_21315	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6754_21315	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6754_21320	COG1609	Transcriptional regulator
K6754_21335	COG2203	Gaf domain
K6754_21335	COG2200	EAL domain
K6754_21335	COG2199	diguanylate cyclase activity
K6754_21340	COG0765	amino acid transport
K6754_21345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6754_21350	COG0765	amino acid transport
K6754_21355	COG1126	abc transporter atp-binding protein
K6754_21365	COG1979	alcohol dehydrogenase
K6754_21370	COG2207	Transcriptional regulator
K6754_21380	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K6754_21385	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K6754_21390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6754_21405	COG0546	phosphoglycolate phosphatase activity
K6754_21410	COG0840	transmembrane signaling receptor activity
K6754_21420	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
K6754_21425	COG0513	Belongs to the DEAD box helicase family
K6754_21445	COG3038	cytochrome b561
K6754_21450	COG2353	YceI-like domain
K6754_21455	COG2116	formate transmembrane transporter activity
K6754_21460	COG0583	DNA-binding transcription factor activity
K6754_21470	COG3593	DNA synthesis involved in DNA repair
K6754_21475	COG0737	Belongs to the 5'-nucleotidase family
K6754_21500	COG2267	carboxylic ester hydrolase activity
K6754_21505	COG2067	long-chain fatty acid transport protein
K6754_21520	COG2050	protein possibly involved in aromatic compounds catabolism
K6754_21530	COG4533	DNA binding
K6754_21565	COG5001	Diguanylate cyclase
K6754_21565	COG3300	MHYT domain
K6754_21570	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K6754_21580	COG4181	ATPase activity
K6754_21585	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K6754_21595	COG1984	allophanate hydrolase subunit 2
K6754_21600	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K6754_21605	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K6754_21610	COG5002	protein histidine kinase activity
K6754_21610	COG5001	Diguanylate cyclase
K6754_21610	COG3447	MASE1 domain protein
K6754_21625	COG0583	DNA-binding transcription factor activity
K6754_21630	COG0045	succinate-CoA ligase (ADP-forming) activity
K6754_21630	COG1042	CoA-binding domain protein
K6754_21630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6754_21640	COG1181	Belongs to the D-alanine--D-alanine ligase family
K6754_21650	COG0023	Translation Initiation Factor
K6754_21785	COG0583	DNA-binding transcription factor activity
K6754_21800	COG3140	Belongs to the UPF0181 family
K6754_21825	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K6754_21830	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K6754_21850	COG4251	negative regulation of phosphorylation
K6754_21850	COG2203	Gaf domain
K6754_21850	COG5001	Diguanylate cyclase
K6754_21850	COG3706	GGDEF domain
K6754_21860	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K6754_21865	COG4149	molybdate abc transporter
K6754_21870	COG0725	ABC transporter, periplasmic molybdate-binding protein
K6754_21880	COG3111	PFAM Bacterial OB fold (BOF) protein
K6754_21890	COG4067	protein conserved in archaea
K6754_21890	COG0189	ligase activity
K6754_21900	COG2207	Transcriptional regulator
K6754_21905	COG0534	Mate efflux family protein
K6754_21910	COG0602	queuosine metabolic process
K6754_21915	COG1328	CTP reductase activity
K6754_21945	COG1794	racemase activity, acting on amino acids and derivatives
K6754_21950	COG0384	phenazine biosynthesis protein PhzF
K6754_21965	COG0243	molybdopterin cofactor binding
K6754_21970	COG0583	DNA-binding transcription factor activity
K6754_21975	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K6754_21985	COG2197	response regulator
K6754_21990	COG3851	Histidine kinase
K6754_21995	COG2271	Major facilitator Superfamily
K6754_22020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6754_22025	COG3118	belongs to the thioredoxin family
K6754_22060	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K6754_22080	COG2116	formate transmembrane transporter activity
K6754_22090	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6754_22095	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6754_22115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K6754_22165	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K6754_22180	COG0277	FAD linked oxidase domain protein
K6754_22185	COG0583	DNA-binding transcription factor activity
K6754_22200	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K6754_22215	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
K6754_22225	COG1288	antiporter activity
K6754_22235	COG3040	lipid binding
K6754_22245	COG0419	ATPase involved in DNA repair
K6754_22250	COG0420	3'-5' exonuclease activity
K6754_22320	COG0631	protein serine/threonine phosphatase activity
K6754_22355	COG0515	serine threonine protein kinase
K6754_22355	COG2815	serine threonine protein kinase
K6754_22400	COG2146	nitrite reductase [NAD(P)H] activity
K6754_22400	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6754_22405	COG1116	anion transmembrane transporter activity
K6754_22410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6754_22415	COG1116	anion transmembrane transporter activity
K6754_22415	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K6754_22440	COG0243	molybdopterin cofactor binding
K6754_22450	COG0814	amino acid
K6754_22510	COG2847	Copper chaperone PCu(A)C
K6754_22515	COG1028	Short-chain dehydrogenase reductase Sdr
K6754_22520	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K6754_22530	COG0800	Aldolase
K6754_22535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6754_22540	COG1917	Cupin 2, conserved barrel domain protein
K6754_22585	COG2186	Transcriptional regulator
K6754_22590	COG2186	Transcriptional regulator
K6754_22595	COG0517	IMP dehydrogenase activity
K6754_22600	COG2176	DNA-directed DNA polymerase activity
K6754_22605	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6754_22675	COG4160	amino acid transport
K6754_22680	COG4215	(ABC) transporter
K6754_22685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6754_22690	COG1126	abc transporter atp-binding protein
K6754_22720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6754_22730	COG1012	belongs to the aldehyde dehydrogenase family
K6754_22745	COG0446	pyridine nucleotide-disulphide oxidoreductase
K6754_22745	COG1902	pentaerythritol trinitrate reductase activity
K6754_22750	COG0109	protoheme IX farnesyltransferase activity
K6754_22755	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K6754_22760	COG1845	cytochrome c oxidase, subunit III
K6754_22765	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K6754_22770	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K6754_22775	COG1028	Short-chain dehydrogenase reductase Sdr
K6754_22785	COG1024	Enoyl-CoA hydratase
K6754_22790	COG1024	Enoyl-CoA hydratase
K6754_22805	COG0183	Belongs to the thiolase family
K6754_22815	COG1960	acyl-CoA dehydrogenase activity
K6754_22820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K6754_22825	COG1024	Enoyl-CoA hydratase
K6754_22840	COG0277	FAD linked oxidase domain protein
K6754_22840	COG0247	lactate metabolic process
K6754_22900	COG2095	MarC family integral membrane protein
K6754_22915	COG0523	cobalamin synthesis protein
K6754_22920	COG0739	heme binding
K6754_22925	COG2988	succinylglutamate desuccinylase activity
K6754_22930	COG0523	cobalamin synthesis protein
K6754_22940	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K6754_22945	COG0735	belongs to the Fur family
K6754_22960	COG0730	response to heat
K6754_22975	COG1073	alpha beta
K6754_22980	COG1073	alpha beta
K6754_22990	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K6754_23000	COG0513	Belongs to the DEAD box helicase family
K6754_23005	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
K6754_23040	COG1119	ATPase activity
K6754_23045	COG2200	EAL domain
K6754_23065	COG0513	Belongs to the DEAD box helicase family
K6754_23070	COG0523	cobalamin synthesis protein
K6754_23080	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
K6754_23090	COG1278	Cold shock
K6754_23095	COG0133	tryptophan synthase activity
K6754_23105	COG4628	conserved protein (DUF2132)
K6754_23110	COG0513	Belongs to the DEAD box helicase family
K6754_23115	COG2814	Major facilitator Superfamily
K6754_23130	COG3530	Putative quorum-sensing-regulated virulence factor
K6754_23155	COG3186	Phenylalanine-4-hydroxylase
K6754_23160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6754_23165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K6754_23190	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
K6754_23195	COG1454	alcohol dehydrogenase
K6754_23200	COG2133	pyrroloquinoline quinone binding
K6754_23210	COG0783	Belongs to the Dps family
K6754_23215	COG0840	transmembrane signaling receptor activity
K6754_23240	COG0784	Response regulator, receiver
K6754_23240	COG2205	protein histidine kinase activity
K6754_23245	COG1538	Outer membrane efflux protein
K6754_23255	COG1132	(ABC) transporter
K6754_23270	COG2199	diguanylate cyclase activity
K6754_23275	COG3036	rescue of stalled ribosome
K6754_23280	COG1278	Cold shock
K6754_23310	COG0545	Peptidyl-prolyl cis-trans isomerase
K6754_23315	COG0109	protoheme IX farnesyltransferase activity
K6754_23320	COG1612	heme a metabolic process
K6754_23340	COG1845	cytochrome c oxidase, subunit III
K6754_23345	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K6754_23350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K6754_23355	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K6754_23360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6754_23370	COG1280	lysine exporter protein (LysE YggA)
K6754_23390	COG0179	Fumarylacetoacetate (FAA) hydrolase
K6754_23400	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6754_23405	COG0697	spore germination
K6754_23420	COG2814	Major facilitator Superfamily
K6754_23425	COG0583	DNA-binding transcription factor activity
K6754_23430	COG5001	Diguanylate cyclase
K6754_23435	COG0739	heme binding
K6754_23455	COG3314	Sporulation integral membrane protein YlbJ
K6754_23470	COG0814	amino acid
K6754_23495	COG4989	oxidoreductase activity
K6754_23520	COG1733	regulation of RNA biosynthetic process
K6754_23535	COG0798	PFAM Bile acid sodium symporter
K6754_23545	COG1881	PFAM PEBP family protein
K6754_23560	COG1131	(ABC) transporter
K6754_23565	COG0842	Transport permease protein
K6754_23575	COG3383	formate dehydrogenase (NAD+) activity
K6754_23595	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6754_23620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6754_23630	COG2067	long-chain fatty acid transport protein
K6754_23640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6754_23650	COG1505	serine-type exopeptidase activity
K6754_23655	COG0488	(ABC) transporter
K6754_23660	COG0589	response to stress
K6754_23665	COG2249	NAD(P)H dehydrogenase (quinone) activity
K6754_23685	COG0366	Alpha amylase catalytic
K6754_23690	COG0789	Transcriptional regulator
K6754_23695	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K6754_23705	COG4934	collagen metabolic process
K6754_23715	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K6754_23720	COG0583	DNA-binding transcription factor activity
K6754_23740	COG2610	gluconate transmembrane transporter activity
K6754_23745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6754_23750	COG3622	Belongs to the hyi family
K6754_23755	COG0235	Class ii aldolase
K6754_23760	COG3395	kinase activity
K6754_23765	COG2084	Dehydrogenase
K6754_23770	COG1349	DNA-binding transcription factor activity
K6754_23780	COG0747	negative chemotaxis
K6754_23785	COG4608	Belongs to the ABC transporter superfamily
K6754_23790	COG0444	Belongs to the ABC transporter superfamily
K6754_23795	COG0534	Mate efflux family protein
K6754_23880	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K6754_23885	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6754_23890	COG0784	Response regulator, receiver
K6754_23890	COG0835	chemotaxis
K6754_23900	COG0748	coenzyme F420 binding
K6754_23905	COG3721	Heme iron utilization protein
K6754_23915	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K6754_23920	COG0811	peptide transport
K6754_23925	COG0848	biopolymer transport protein
K6754_23935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6754_23940	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K6754_23980	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K6754_23990	COG3217	Mosc domain protein beta barrel domain protein
K6754_23990	COG0633	Ferredoxin
K6754_23990	COG0633	Ferredoxin
K6754_23990	COG3217	Mosc domain protein beta barrel domain protein
K6754_23995	COG0401	homolog of Blt101
K6754_24000	COG0418	dihydroorotase activity
K6754_24005	COG2354	Protein conserved in bacteria
K6754_24015	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6754_24020	COG4605	iron ion homeostasis
K6754_24025	COG4607	ABC-type enterochelin transport system periplasmic component
K6754_24030	COG4774	siderophore transport
K6754_24035	COG1132	(ABC) transporter
K6754_24035	COG2375	cellular response to nickel ion
K6754_24065	COG3833	ABC-type maltose transport systems, permease component
K6754_24070	COG1175	transmembrane transport
K6754_24080	COG3842	ATPase activity
K6754_24085	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity