locus-tag	class	description
VA208B3_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VA208B3_00020	COG0592	DNA-directed DNA polymerase activity
VA208B3_00030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VA208B3_00040	COG0187	DNA topoisomerase II activity
VA208B3_00060	COG0071	Belongs to the small heat shock protein (HSP20) family
VA208B3_00070	COG3977	Valine--pyruvate aminotransferase
VA208B3_00080	COG0366	Alpha amylase catalytic
VA208B3_00090	COG0751	glycine-tRNA ligase activity
VA208B3_00100	COG0752	glycyl-tRNA synthetase alpha subunit
VA208B3_00110	COG2119	membrane
VA208B3_00130	COG0425	Belongs to the sulfur carrier protein TusA family
VA208B3_00160	COG0604	alcohol dehydrogenase
VA208B3_00170	COG0183	Belongs to the thiolase family
VA208B3_00180	COG1024	Enoyl-CoA hydratase
VA208B3_00180	COG1250	3-hydroxyacyl-CoA dehydrogenase
VA208B3_00190	COG1739	Uncharacterized protein family UPF0029
VA208B3_00200	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VA208B3_00220	COG0583	DNA-binding transcription factor activity
VA208B3_00230	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VA208B3_00240	COG2960	long-chain fatty acid transporting porin activity
VA208B3_00250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VA208B3_00260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VA208B3_00310	COG4172	Belongs to the ABC transporter superfamily
VA208B3_00320	COG0747	negative chemotaxis
VA208B3_00330	COG0601	transmembrane transport
VA208B3_00340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VA208B3_00410	COG1609	Transcriptional regulator
VA208B3_00420	COG0583	DNA-binding transcription factor activity
VA208B3_00450	COG0129	dihydroxy-acid dehydratase activity
VA208B3_00460	COG3265	gluconokinase activity
VA208B3_00470	COG2610	gluconate transmembrane transporter activity
VA208B3_00480	COG0800	Aldolase
VA208B3_00490	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
VA208B3_00500	COG0583	DNA-binding transcription factor activity
VA208B3_00510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VA208B3_00520	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VA208B3_00530	COG0339	signal peptide processing
VA208B3_00540	COG1522	sequence-specific DNA binding
VA208B3_00550	COG5001	Diguanylate cyclase
VA208B3_00550	COG5002	protein histidine kinase activity
VA208B3_00560	COG0742	ribosomal rna small subunit methyltransferase
VA208B3_00590	COG0589	response to stress
VA208B3_00600	COG1528	Iron-storage protein
VA208B3_00620	COG2081	HI0933 family
VA208B3_00640	COG2823	Periplasmic or secreted lipoprotein
VA208B3_00740	COG0628	permease
VA208B3_00770	COG1322	Protein conserved in bacteria
VA208B3_00780	COG2226	methyltransferase
VA208B3_00790	COG3165	ubiquinone biosynthetic process from chorismate
VA208B3_00800	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VA208B3_00810	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VA208B3_00820	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VA208B3_00830	COG0805	protein transport
VA208B3_00840	COG0084	hydrolase, TatD family'
VA208B3_00870	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VA208B3_00870	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VA208B3_00880	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VA208B3_00940	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VA208B3_00960	COG2204	response regulator
VA208B3_00970	COG3852	Histidine kinase
VA208B3_00990	COG0174	glutamine synthetase
VA208B3_01000	COG1217	gtp-binding protein TYPA
VA208B3_01030	COG1295	ribonuclease BN
VA208B3_01040	COG1490	D-aminoacyl-tRNA deacylase activity
VA208B3_01050	COG0456	acetyltransferase
VA208B3_01070	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VA208B3_01080	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VA208B3_01090	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VA208B3_01100	COG3031	protein transport across the cell outer membrane
VA208B3_01120	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VA208B3_01130	COG1459	type II secretion system
VA208B3_01140	COG2165	general secretion pathway protein
VA208B3_01150	COG2165	general secretion pathway protein
VA208B3_01160	COG2165	general secretion pathway protein
VA208B3_01170	COG4795	General secretion pathway protein
VA208B3_01180	COG3156	type II secretion system protein K
VA208B3_01190	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VA208B3_01200	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VA208B3_01220	COG1218	3'(2'),5'-bisphosphate nucleotidase
VA208B3_01230	COG0494	nUDIX hydrolase
VA208B3_01240	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VA208B3_01240	COG0316	Belongs to the HesB IscA family
VA208B3_01250	COG0596	Alpha beta hydrolase
VA208B3_01270	COG2183	response to ionizing radiation
VA208B3_01290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VA208B3_01330	COG2233	PERMEase
VA208B3_01350	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VA208B3_01360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VA208B3_01370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VA208B3_01380	COG1758	RNA polymerase activity
VA208B3_01390	COG0194	GDP metabolic process
VA208B3_01420	COG0848	biopolymer transport protein
VA208B3_01430	COG0811	peptide transport
VA208B3_01470	COG4174	ABC transporter (Permease)
VA208B3_01480	COG4239	(ABC) transporter, permease
VA208B3_01490	COG0747	negative chemotaxis
VA208B3_01500	COG0444	Belongs to the ABC transporter superfamily
VA208B3_01510	COG4608	Belongs to the ABC transporter superfamily
VA208B3_01590	COG1061	Type III restriction enzyme res subunit
VA208B3_01680	COG1561	YicC-like family, N-terminal region
VA208B3_01690	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VA208B3_01700	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VA208B3_01710	COG1560	Kdo2-lipid A biosynthetic process
VA208B3_01720	COG1309	transcriptional regulator
VA208B3_01730	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VA208B3_01750	COG2003	Belongs to the UPF0758 family
VA208B3_01760	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VA208B3_01790	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VA208B3_01820	COG0438	transferase activity, transferring glycosyl groups
VA208B3_01830	COG0463	Glycosyl transferase, family 2
VA208B3_01840	COG0859	PFAM glycosyl transferase family 9
VA208B3_01850	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VA208B3_01860	COG3642	lipopolysaccharide core region biosynthetic process
VA208B3_01900	COG0110	maltose O-acetyltransferase activity
VA208B3_01910	COG2030	dehydratase
VA208B3_01950	COG0438	transferase activity, transferring glycosyl groups
VA208B3_01950	COG0297	glycogen (starch) synthase activity
VA208B3_01970	COG1519	Transferase
VA208B3_01980	COG0859	PFAM glycosyl transferase family 9
VA208B3_01990	COG1560	Kdo2-lipid A biosynthetic process
VA208B3_02010	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VA208B3_02080	COG1086	Polysaccharide biosynthesis protein
VA208B3_02090	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VA208B3_02100	COG1083	cytidylyl-transferase
VA208B3_02140	COG2089	acid synthase
VA208B3_02150	COG1216	Glycosyl transferase, family 2
VA208B3_02150	COG0463	Glycosyl transferase, family 2
VA208B3_02200	COG1216	Glycosyl transferase, family 2
VA208B3_02210	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VA208B3_02250	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VA208B3_02260	COG0149	triose-phosphate isomerase activity
VA208B3_02310	COG1494	fructose-1,6-bisphosphatase
VA208B3_02320	COG3074	FtsZ-dependent cytokinesis
VA208B3_02330	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VA208B3_02340	COG1575	Belongs to the MenA family. Type 1 subfamily
VA208B3_02400	COG2003	Belongs to the UPF0758 family
VA208B3_02430	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VA208B3_02440	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VA208B3_02460	COG1609	Transcriptional regulator
VA208B3_02470	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VA208B3_02480	COG0254	rRNA binding
VA208B3_02500	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VA208B3_02510	COG0088	Forms part of the polypeptide exit tunnel
VA208B3_02530	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VA208B3_02540	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VA208B3_02550	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VA208B3_02560	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VA208B3_02580	COG0255	Belongs to the universal ribosomal protein uL29 family
VA208B3_02590	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VA208B3_02600	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VA208B3_02610	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VA208B3_02620	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VA208B3_02630	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VA208B3_02640	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VA208B3_02650	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VA208B3_02680	COG1841	ribosomal large subunit assembly
VA208B3_02690	COG0200	Binds to the 23S rRNA
VA208B3_02700	COG0201	protein transport
VA208B3_02710	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VA208B3_02720	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VA208B3_02740	COG0202	RNA polymerase activity
VA208B3_02750	COG0203	ribosomal protein L17
VA208B3_02770	COG0545	Peptidyl-prolyl cis-trans isomerase
VA208B3_02790	COG2153	protein acetylation
VA208B3_02800	COG0513	Belongs to the DEAD box helicase family
VA208B3_02820	COG0737	Belongs to the 5'-nucleotidase family
VA208B3_02830	COG1648	precorrin-2 dehydrogenase activity
VA208B3_02830	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VA208B3_02840	COG0175	sulfate reduction
VA208B3_02850	COG2895	sulfate adenylyltransferase (ATP) activity
VA208B3_02860	COG3273	potassium ion transport
VA208B3_02860	COG0471	metal ion transport
VA208B3_02870	COG0529	Catalyzes the synthesis of activated sulfate
VA208B3_02910	COG4181	ATPase activity
VA208B3_02930	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VA208B3_02950	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VA208B3_02960	COG0729	surface antigen
VA208B3_02980	COG2105	PFAM AIG2 family protein
VA208B3_03000	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VA208B3_03010	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VA208B3_03020	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VA208B3_03030	COG0163	prenyltransferase activity
VA208B3_03040	COG4143	(ABC) transporter
VA208B3_03050	COG1178	ABC-type Fe3 transport system permease component
VA208B3_03060	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VA208B3_03090	COG2358	TRAP transporter, solute receptor (TAXI family
VA208B3_03110	COG0039	L-malate dehydrogenase activity
VA208B3_03130	COG0142	geranyltranstransferase activity
VA208B3_03140	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VA208B3_03160	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VA208B3_03170	COG2966	Psort location CytoplasmicMembrane, score
VA208B3_03200	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VA208B3_03210	COG2967	ApaG domain
VA208B3_03220	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VA208B3_03230	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VA208B3_03240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VA208B3_03250	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VA208B3_03260	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VA208B3_03280	COG0066	3-isopropylmalate dehydratase activity
VA208B3_03290	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VA208B3_03300	COG0473	3-isopropylmalate dehydrogenase activity
VA208B3_03310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VA208B3_03350	COG0583	DNA-binding transcription factor activity
VA208B3_03360	COG1022	Amp-dependent synthetase and ligase
VA208B3_03370	COG0028	Belongs to the TPP enzyme family
VA208B3_03380	COG0440	acetolactate synthase activity
VA208B3_03410	COG0469	pyruvate kinase activity
VA208B3_03420	COG1349	DNA-binding transcription factor activity
VA208B3_03430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VA208B3_03460	COG5002	protein histidine kinase activity
VA208B3_03470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VA208B3_03480	COG3722	fumarate hydratase activity
VA208B3_03490	COG0246	Mannitol dehydrogenase
VA208B3_03500	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VA208B3_03500	COG2213	PTS system mannitol-specific
VA208B3_03560	COG1464	Belongs to the NlpA lipoprotein family
VA208B3_03710	COG0786	glutamate:sodium symporter activity
VA208B3_03740	COG0640	Transcriptional regulator
VA208B3_03830	COG0358	DNA primase activity
VA208B3_03840	COG1610	YqeY-like protein
VA208B3_03850	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VA208B3_03860	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VA208B3_03870	COG0596	Alpha beta hydrolase
VA208B3_03880	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VA208B3_03890	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VA208B3_03900	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VA208B3_03910	COG1968	undecaprenyl-diphosphatase activity
VA208B3_03920	COG0617	tRNA 3'-terminal CCA addition
VA208B3_03930	COG3267	Type II secretory pathway component ExeA
VA208B3_03930	COG3409	Peptidoglycan-binding domain 1 protein
VA208B3_03950	COG4991	sh3 domain protein
VA208B3_03960	COG0306	phosphate transporter
VA208B3_03970	COG1392	Phosphate transport regulator
VA208B3_03980	COG3025	triphosphatase activity
VA208B3_04010	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VA208B3_04020	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VA208B3_04020	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VA208B3_04030	COG1538	Outer membrane efflux protein
VA208B3_04040	COG0494	nUDIX hydrolase
VA208B3_04050	COG3151	Protein conserved in bacteria
VA208B3_04070	COG3150	esterase
VA208B3_04090	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VA208B3_04100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VA208B3_04120	COG3105	Protein conserved in bacteria
VA208B3_04130	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VA208B3_04140	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VA208B3_04150	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VA208B3_04160	COG0723	plastoquinol--plastocyanin reductase activity
VA208B3_04170	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VA208B3_04180	COG2857	Cytochrome c1
VA208B3_04190	COG0625	glutathione transferase activity
VA208B3_04200	COG2969	positive regulation of protein catabolic process
VA208B3_04210	COG2823	Periplasmic or secreted lipoprotein
VA208B3_04220	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VA208B3_04230	COG0792	nuclease activity
VA208B3_04250	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VA208B3_04260	COG0275	rRNA processing
VA208B3_04270	COG3116	cell division
VA208B3_04280	COG0768	penicillin binding
VA208B3_04290	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VA208B3_04300	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VA208B3_04310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VA208B3_04320	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VA208B3_04330	COG0772	Belongs to the SEDS family
VA208B3_04340	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VA208B3_04350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VA208B3_04360	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VA208B3_04370	COG0849	cell division
VA208B3_04380	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VA208B3_04390	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VA208B3_04410	COG0653	protein targeting
VA208B3_04420	COG0494	nUDIX hydrolase
VA208B3_04430	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VA208B3_04440	COG0505	Belongs to the CarA family
VA208B3_04450	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VA208B3_04480	COG0730	response to heat
VA208B3_04490	COG0583	DNA-binding transcription factor activity
VA208B3_04500	COG2860	membrane
VA208B3_04510	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VA208B3_04530	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VA208B3_04550	COG0493	'glutamate synthase
VA208B3_04560	COG0067	glutamate synthase
VA208B3_04560	COG0069	glutamate synthase activity
VA208B3_04560	COG0070	glutamate synthase
VA208B3_04580	COG0067	glutamate synthase
VA208B3_04580	COG0069	glutamate synthase activity
VA208B3_04580	COG0070	glutamate synthase
VA208B3_04590	COG1242	4 iron, 4 sulfur cluster binding
VA208B3_04600	COG5001	Diguanylate cyclase
VA208B3_04600	COG4251	negative regulation of phosphorylation
VA208B3_04600	COG3706	GGDEF domain
VA208B3_04600	COG2203	Gaf domain
VA208B3_04610	COG5002	protein histidine kinase activity
VA208B3_04610	COG0784	Response regulator, receiver
VA208B3_04610	COG2198	Histidine kinase
VA208B3_04630	COG0745	RESPONSE REGULATOR receiver
VA208B3_04650	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VA208B3_04680	COG0083	homoserine kinase activity
VA208B3_04690	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VA208B3_04700	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VA208B3_04710	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VA208B3_04720	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VA208B3_04750	COG1115	amino acid carrier protein
VA208B3_04760	COG3022	response to hydroperoxide
VA208B3_04770	COG0513	Belongs to the DEAD box helicase family
VA208B3_04780	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VA208B3_04800	COG0716	FMN binding
VA208B3_04810	COG4974	Belongs to the 'phage' integrase family
VA208B3_04820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VA208B3_04830	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VA208B3_04840	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VA208B3_04850	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VA208B3_04880	COG0667	Aldo Keto reductase
VA208B3_04900	COG3066	DNA modification
VA208B3_04910	COG0494	nUDIX hydrolase
VA208B3_04930	COG0730	response to heat
VA208B3_04940	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VA208B3_04950	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VA208B3_04970	COG1283	sodium-dependent phosphate transmembrane transporter activity
VA208B3_04980	COG0583	DNA-binding transcription factor activity
VA208B3_04990	COG0640	Transcriptional regulator
VA208B3_05000	COG0268	Binds directly to 16S ribosomal RNA
VA208B3_05010	COG0728	peptidoglycan biosynthetic process
VA208B3_05020	COG0196	riboflavin kinase activity
VA208B3_05030	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VA208B3_05040	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VA208B3_05050	COG1047	Peptidyl-prolyl cis-trans
VA208B3_05060	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VA208B3_05070	COG3279	Response regulator of the LytR AlgR family
VA208B3_05080	COG3275	phosphorelay sensor kinase activity
VA208B3_05090	COG1966	Carbon starvation protein
VA208B3_05120	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VA208B3_05130	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VA208B3_05140	COG1472	Belongs to the glycosyl hydrolase 3 family
VA208B3_05150	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VA208B3_05160	COG0287	Prephenate dehydrogenase
VA208B3_05160	COG1605	Chorismate mutase
VA208B3_05170	COG0739	heme binding
VA208B3_05200	COG0488	(ABC) transporter
VA208B3_05220	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VA208B3_05230	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VA208B3_05240	COG1605	Chorismate mutase
VA208B3_05240	COG0077	Prephenate dehydratase
VA208B3_05250	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VA208B3_05260	COG0741	lytic transglycosylase activity
VA208B3_05270	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VA208B3_05280	COG0564	pseudouridine synthase activity
VA208B3_05300	COG0542	response to heat
VA208B3_05340	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VA208B3_05350	COG0826	peptidase U32
VA208B3_05360	COG2974	May be involved in recombination
VA208B3_05370	COG0745	RESPONSE REGULATOR receiver
VA208B3_05380	COG5002	protein histidine kinase activity
VA208B3_05400	COG0248	Ppx GppA phosphatase
VA208B3_05410	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VA208B3_05430	COG0581	inorganic phosphate transmembrane transporter activity
VA208B3_05440	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VA208B3_05450	COG0704	Plays a role in the regulation of phosphate uptake
VA208B3_05470	COG3142	Participates in the control of copper homeostasis
VA208B3_05480	COG0450	alkyl hydroperoxide reductase
VA208B3_05490	COG0583	DNA-binding transcription factor activity
VA208B3_05500	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VA208B3_05520	COG0517	IMP dehydrogenase activity
VA208B3_05540	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VA208B3_05550	COG0343	queuine tRNA-ribosyltransferase activity
VA208B3_05560	COG1862	Preprotein translocase
VA208B3_05570	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VA208B3_05580	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VA208B3_05590	COG0483	inositol monophosphate 1-phosphatase activity
VA208B3_05620	COG1104	cysteine desulfurase activity
VA208B3_05630	COG0822	iron-sulfur transferase activity
VA208B3_05650	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VA208B3_05660	COG0443	Heat shock 70 kDa protein
VA208B3_05670	COG0633	Ferredoxin
VA208B3_05680	COG2975	iron-sulfur cluster assembly
VA208B3_05690	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VA208B3_05700	COG0105	UTP biosynthetic process
VA208B3_05710	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VA208B3_05730	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VA208B3_05740	COG0124	histidyl-tRNA synthetase
VA208B3_05750	COG2976	Protein conserved in bacteria
VA208B3_05760	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VA208B3_05770	COG1160	GTP binding
VA208B3_05800	COG1570	exodeoxyribonuclease VII activity
VA208B3_05810	COG0517	IMP dehydrogenase activity
VA208B3_05810	COG0516	GMP reductase activity
VA208B3_05820	COG0519	Catalyzes the synthesis of GMP from XMP
VA208B3_05820	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VA208B3_05830	COG0582	viral genome integration into host DNA
VA208B3_06020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VA208B3_06040	COG1757	Na H antiporter
VA208B3_06060	COG1584	GPR1 FUN34 yaaH family protein
VA208B3_06080	COG1115	amino acid carrier protein
VA208B3_06140	COG2873	o-acetylhomoserine
VA208B3_06150	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VA208B3_06190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VA208B3_06190	COG3153	acetyltransferase
VA208B3_06200	COG0583	DNA-binding transcription factor activity
VA208B3_06240	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VA208B3_06300	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VA208B3_06310	COG2867	negative regulation of translational initiation
VA208B3_06320	COG2914	Belongs to the UPF0125 (RnfH) family
VA208B3_06330	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VA208B3_06340	COG0497	DNA recombination
VA208B3_06360	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VA208B3_06370	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VA208B3_06390	COG0443	Heat shock 70 kDa protein
VA208B3_06400	COG0484	heat shock protein binding
VA208B3_06420	COG4969	Belongs to the N-Me-Phe pilin family
VA208B3_06470	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VA208B3_06490	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VA208B3_06500	COG0047	phosphoribosylformylglycinamidine synthase activity
VA208B3_06500	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VA208B3_06550	COG2195	Cleaves the N-terminal amino acid of tripeptides
VA208B3_06560	COG2252	PERMEase
VA208B3_06570	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VA208B3_06580	COG1073	alpha beta
VA208B3_06600	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VA208B3_06610	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VA208B3_06620	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VA208B3_06630	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VA208B3_06630	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VA208B3_06670	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VA208B3_06680	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VA208B3_06690	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VA208B3_06700	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VA208B3_06710	COG0142	geranyltranstransferase activity
VA208B3_06720	COG1722	exodeoxyribonuclease VII activity
VA208B3_06730	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VA208B3_06740	COG2885	chlorophyll binding
VA208B3_06750	COG0301	tRNA thio-modification
VA208B3_06750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VA208B3_06760	COG0583	DNA-binding transcription factor activity
VA208B3_06780	COG2363	Small membrane protein
VA208B3_06790	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
VA208B3_06810	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VA208B3_06820	COG1611	Belongs to the LOG family
VA208B3_06850	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VA208B3_06850	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VA208B3_06870	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VA208B3_06880	COG1464	Belongs to the NlpA lipoprotein family
VA208B3_06890	COG2011	ABC-type metal ion transport system permease component
VA208B3_06900	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VA208B3_06910	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VA208B3_06930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VA208B3_06930	COG1263	PTS System
VA208B3_06940	COG0366	Alpha amylase catalytic
VA208B3_06970	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VA208B3_06980	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VA208B3_06990	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VA208B3_07000	COG0321	lipoyl(octanoyl) transferase activity
VA208B3_07010	COG2921	Belongs to the UPF0250 family
VA208B3_07020	COG1686	Belongs to the peptidase S11 family
VA208B3_07030	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VA208B3_07040	COG0772	Belongs to the SEDS family
VA208B3_07050	COG0768	penicillin binding
VA208B3_07060	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VA208B3_07070	COG0799	negative regulation of ribosome biogenesis
VA208B3_07080	COG1466	dna polymerase III delta subunit
VA208B3_07090	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VA208B3_07100	COG0495	leucyl-tRNA aminoacylation
VA208B3_07110	COG2888	peptidyl-tyrosine sulfation
VA208B3_07120	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VA208B3_07130	COG4535	Mg2 and Co2 transporter CorC
VA208B3_07140	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VA208B3_07150	COG1702	phosphate starvation-inducible protein PhoH
VA208B3_07160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VA208B3_07170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VA208B3_07180	COG0012	GTP binding
VA208B3_07190	COG0193	aminoacyl-tRNA hydrolase activity
VA208B3_07200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VA208B3_07210	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VA208B3_07220	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
VA208B3_07230	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VA208B3_07240	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VA208B3_07250	COG2890	protein-(glutamine-N5) methyltransferase activity
VA208B3_07260	COG3094	Invasion gene expression up-regulator, SirB
VA208B3_07270	COG2912	Transglutaminase-like superfamily
VA208B3_07280	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VA208B3_07290	COG0737	Belongs to the 5'-nucleotidase family
VA208B3_07310	COG1187	pseudouridine synthase activity
VA208B3_07320	COG2840	Smr protein MutS2
VA208B3_07380	COG2608	mercury ion transmembrane transporter activity
VA208B3_07380	COG2217	Heavy metal translocating P-type atpase
VA208B3_07400	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VA208B3_07410	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VA208B3_07500	COG0835	chemotaxis
VA208B3_07500	COG0784	Response regulator, receiver
VA208B3_07510	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VA208B3_07520	COG1815	bacterial-type flagellum-dependent cell motility
VA208B3_07530	COG1558	bacterial-type flagellum-dependent cell motility
VA208B3_07550	COG1749	Flagellar hook protein flgE
VA208B3_07560	COG4787	bacterial-type flagellum-dependent cell motility
VA208B3_07580	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VA208B3_07590	COG1706	bacterial-type flagellum-dependent cell motility
VA208B3_07600	COG3951	Flagellar rod assembly protein muramidase FlgJ
VA208B3_07600	COG1705	Flagellar rod assembly protein muramidase FlgJ
VA208B3_07620	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VA208B3_07630	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VA208B3_07640	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VA208B3_07650	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VA208B3_07660	COG2190	(PTS) system
VA208B3_07670	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VA208B3_07680	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VA208B3_07690	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VA208B3_07700	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VA208B3_07710	COG3115	cell septum assembly
VA208B3_07720	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VA208B3_07770	COG0330	HflC and HflK could
VA208B3_07780	COG2194	sulfuric ester hydrolase activity
VA208B3_07820	COG3335	DDE superfamily endonuclease
VA208B3_07850	COG1215	transferase activity, transferring glycosyl groups
VA208B3_07860	COG1215	transferase activity, transferring glycosyl groups
VA208B3_07870	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
VA208B3_07880	COG3118	belongs to the thioredoxin family
VA208B3_07880	COG0457	Tetratricopeptide repeat
VA208B3_07890	COG3118	belongs to the thioredoxin family
VA208B3_07900	COG0300	oxidoreductase activity
VA208B3_07910	COG1090	epimerase
VA208B3_07970	COG0622	Phosphoesterase
VA208B3_08010	COG3710	Transcriptional regulator
VA208B3_08020	COG0326	Molecular chaperone. Has ATPase activity
VA208B3_08030	COG0563	adenylate kinase activity
VA208B3_08040	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VA208B3_08050	COG3104	oligopeptide transport
VA208B3_08060	COG0250	Participates in transcription elongation, termination and antitermination
VA208B3_08070	COG0367	asparagine synthase
VA208B3_08080	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VA208B3_08080	COG4651	solute:proton antiporter activity
VA208B3_08090	COG1940	carbohydrate kinase activity
VA208B3_08090	COG1846	Transcriptional regulator
VA208B3_08100	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VA208B3_08110	COG1263	PTS System
VA208B3_08110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VA208B3_08120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VA208B3_08130	COG0735	belongs to the Fur family
VA208B3_08150	COG0716	FMN binding
VA208B3_08170	COG0596	Alpha beta hydrolase
VA208B3_08180	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VA208B3_08190	COG0033	Phosphoglucomutase
VA208B3_08210	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VA208B3_08240	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VA208B3_08250	COG1053	succinate dehydrogenase
VA208B3_08260	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VA208B3_08270	COG0567	Dehydrogenase, E1 component
VA208B3_08280	COG0508	dehydrogenase complex catalyzes the overall conversion of
VA208B3_08290	COG0045	succinate-CoA ligase (ADP-forming) activity
VA208B3_08310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VA208B3_08320	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VA208B3_08340	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VA208B3_08350	COG2233	PERMEase
VA208B3_08390	COG1393	Belongs to the ArsC family
VA208B3_08400	COG4783	chaperone-mediated protein folding
VA208B3_08430	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VA208B3_08440	COG2716	regulation of RNA biosynthetic process
VA208B3_08450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VA208B3_08460	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VA208B3_08490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VA208B3_08500	COG1393	Belongs to the ArsC family
VA208B3_08550	COG2837	iron assimilation
VA208B3_08560	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VA208B3_08570	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VA208B3_08580	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VA208B3_08590	COG1334	flagellar protein FlaG
VA208B3_08600	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VA208B3_08620	COG1516	flagellar protein fliS
VA208B3_08660	COG1677	Flagellar hook-basal body complex protein FliE
VA208B3_08680	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VA208B3_08780	COG1987	bacterial-type flagellum assembly
VA208B3_08790	COG1684	flagellar biosynthetic protein fliR
VA208B3_08860	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VA208B3_08870	COG0643	Histidine kinase
VA208B3_08870	COG0784	Response regulator, receiver
VA208B3_08870	COG2198	Histidine kinase
VA208B3_08880	COG2201	protein-glutamate methylesterase activity
VA208B3_08890	COG1192	Involved in chromosome partitioning
VA208B3_08910	COG0835	chemotaxis
VA208B3_08930	COG4133	protoheme IX ABC transporter activity
VA208B3_08940	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VA208B3_08950	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VA208B3_08960	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VA208B3_08970	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VA208B3_08980	COG1138	Cytochrome C-type biogenesis protein
VA208B3_08990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VA208B3_09020	COG2853	Lipoprotein
VA208B3_09040	COG2067	long-chain fatty acid transport protein
VA208B3_09070	COG0183	Belongs to the thiolase family
VA208B3_09080	COG1250	3-hydroxyacyl-CoA dehydrogenase
VA208B3_09080	COG1024	Enoyl-CoA hydratase
VA208B3_09110	COG2062	phosphohistidine phosphatase, SixA
VA208B3_09120	COG2840	Smr protein MutS2
VA208B3_09130	COG2890	protein-(glutamine-N5) methyltransferase activity
VA208B3_09140	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VA208B3_09150	COG2860	membrane
VA208B3_09160	COG3101	peptidyl-lysine hydroxylation
VA208B3_09180	COG0431	NADPH-dependent FMN reductase
VA208B3_09190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VA208B3_09190	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VA208B3_09200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VA208B3_09210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VA208B3_09220	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VA208B3_09240	COG0101	tRNA pseudouridine synthase activity
VA208B3_09250	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VA208B3_09260	COG0285	dihydrofolate synthase activity
VA208B3_09270	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VA208B3_09280	COG1286	toxin biosynthetic process
VA208B3_09290	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VA208B3_09300	COG0583	DNA-binding transcription factor activity
VA208B3_09310	COG0745	RESPONSE REGULATOR receiver
VA208B3_09330	COG2832	Protein of unknown function (DUF454)
VA208B3_09340	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VA208B3_09360	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VA208B3_09370	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VA208B3_09380	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VA208B3_09390	COG0814	amino acid
VA208B3_09400	COG0251	oxidation-reduction process
VA208B3_09410	COG3681	Belongs to the UPF0597 family
VA208B3_09440	COG2261	transglycosylase associated protein
VA208B3_09450	COG2983	Belongs to the UPF0260 family
VA208B3_09460	COG0668	transmembrane transport
VA208B3_09470	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
VA208B3_09480	COG0346	lactoylglutathione lyase activity
VA208B3_09500	COG1785	Belongs to the alkaline phosphatase family
VA208B3_09540	COG2226	methyltransferase
VA208B3_09570	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VA208B3_09590	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VA208B3_09610	COG3139	Protein of unknown function (DUF1315)
VA208B3_09620	COG0252	asparaginase activity
VA208B3_09630	COG0616	signal peptide processing
VA208B3_09640	COG1902	pentaerythritol trinitrate reductase activity
VA208B3_09640	COG0446	pyridine nucleotide-disulphide oxidoreductase
VA208B3_09650	COG0778	Nitroreductase
VA208B3_09660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VA208B3_09690	COG0123	including yeast histone deacetylase and acetoin utilization protein
VA208B3_09700	COG3083	sulfuric ester hydrolase activity
VA208B3_09710	COG3082	Protein of unknown function (DUF1414)
VA208B3_09720	COG3081	Nucleoid-associated protein
VA208B3_09750	COG1757	Na H antiporter
VA208B3_09760	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VA208B3_09770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VA208B3_09780	COG2095	MarC family integral membrane protein
VA208B3_09790	COG1012	belongs to the aldehyde dehydrogenase family
VA208B3_09790	COG1454	alcohol dehydrogenase
VA208B3_09830	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VA208B3_09850	COG2056	Na+-H+ antiporter family
VA208B3_09860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VA208B3_09870	COG2885	chlorophyll binding
VA208B3_09890	COG0346	lactoylglutathione lyase activity
VA208B3_09900	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VA208B3_09910	COG4660	Part of a membrane complex involved in electron transport
VA208B3_09920	COG4659	FMN binding
VA208B3_09930	COG4658	electron transport chain
VA208B3_09940	COG4656	Part of a membrane complex involved in electron transport
VA208B3_09950	COG2878	Part of a membrane complex involved in electron transport
VA208B3_09960	COG4657	Part of a membrane complex involved in electron transport
VA208B3_09970	COG0556	nucleotide-excision repair
VA208B3_09980	COG2204	response regulator
VA208B3_09990	COG2198	Histidine kinase
VA208B3_10000	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VA208B3_10010	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VA208B3_10020	COG0521	Mo-molybdopterin cofactor biosynthetic process
VA208B3_10030	COG0315	cyclic pyranopterin monophosphate synthase activity
VA208B3_10040	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VA208B3_10050	COG0314	molybdopterin synthase activity
VA208B3_10070	COG0601	transmembrane transport
VA208B3_10080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VA208B3_10090	COG0444	Belongs to the ABC transporter superfamily
VA208B3_10110	COG0435	Glutathione S-transferase
VA208B3_10130	COG3174	membrane
VA208B3_10140	COG0280	phosphate acetyltransferase
VA208B3_10140	COG0857	belongs to the CobB CobQ family
VA208B3_10150	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VA208B3_10160	COG3092	negative regulation of chromosome organization
VA208B3_10180	COG4120	Belongs to the binding-protein-dependent transport system permease family
VA208B3_10190	COG1122	ATPase activity
VA208B3_10200	COG0366	Alpha amylase catalytic
VA208B3_10220	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VA208B3_10230	COG0653	protein targeting
VA208B3_10240	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VA208B3_10250	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VA208B3_10260	COG2186	Transcriptional regulator
VA208B3_10280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VA208B3_10280	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VA208B3_10290	COG0489	protein tyrosine kinase activity
VA208B3_10300	COG0572	uridine kinase
VA208B3_10320	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VA208B3_10330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VA208B3_10340	COG0659	secondary active sulfate transmembrane transporter activity
VA208B3_10350	COG1530	ribonuclease E activity
VA208B3_10360	COG0564	pseudouridine synthase activity
VA208B3_10370	COG0424	maF-like protein
VA208B3_10380	COG1399	metal-binding, possibly nucleic acid-binding protein
VA208B3_10400	COG0416	fatty acid biosynthetic process
VA208B3_10410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VA208B3_10470	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VA208B3_10480	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VA208B3_10500	COG0084	hydrolase, TatD family'
VA208B3_10510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VA208B3_10510	COG1263	PTS System
VA208B3_10530	COG0733	neurotransmitter:sodium symporter activity
VA208B3_10550	COG4667	esterase of the alpha-beta hydrolase superfamily
VA208B3_10560	COG0469	pyruvate kinase activity
VA208B3_10570	COG1940	carbohydrate kinase activity
VA208B3_10580	COG0784	Response regulator, receiver
VA208B3_10580	COG0835	chemotaxis
VA208B3_10590	COG0587	DNA-directed DNA polymerase activity
VA208B3_10620	COG1028	Short-chain dehydrogenase reductase Sdr
VA208B3_10630	COG0616	signal peptide processing
VA208B3_10640	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VA208B3_10650	COG0539	negative regulation of cytoplasmic translation
VA208B3_10670	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VA208B3_10680	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VA208B3_10690	COG0284	orotidine-5'-phosphate decarboxylase activity
VA208B3_10700	COG4166	transmembrane transport
VA208B3_10750	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
VA208B3_10770	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VA208B3_10770	COG3008	intermembrane lipid transfer
VA208B3_10780	COG2995	paraquat-inducible protein a
VA208B3_10790	COG3258	Cytochrome c
VA208B3_10800	COG2863	cytochrome
VA208B3_10860	COG0583	DNA-binding transcription factor activity
VA208B3_10880	COG4232	protein-disulfide reductase activity
VA208B3_10890	COG3118	belongs to the thioredoxin family
VA208B3_10950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VA208B3_10970	COG0577	efflux transmembrane transporter activity
VA208B3_10970	COG1136	(ABC) transporter
VA208B3_10990	COG0577	efflux transmembrane transporter activity
VA208B3_10990	COG1136	(ABC) transporter
VA208B3_11000	COG1335	isochorismatase
VA208B3_11110	COG3850	Histidine kinase
VA208B3_11110	COG5002	protein histidine kinase activity
VA208B3_11120	COG0745	RESPONSE REGULATOR receiver
VA208B3_11130	COG0840	transmembrane signaling receptor activity
VA208B3_11140	COG1032	radical SAM domain protein
VA208B3_11150	COG2203	Gaf domain
VA208B3_11150	COG4251	negative regulation of phosphorylation
VA208B3_11150	COG3706	GGDEF domain
VA208B3_11150	COG5001	Diguanylate cyclase
VA208B3_11180	COG0583	DNA-binding transcription factor activity
VA208B3_11190	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VA208B3_11210	COG2350	Protein conserved in bacteria
VA208B3_11230	COG2917	probably involved in intracellular septation
VA208B3_11270	COG1301	dicarboxylic acid transport
VA208B3_11280	COG0318	PFAM AMP-dependent synthetase and ligase
VA208B3_11290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VA208B3_11300	COG0159	tryptophan synthase activity
VA208B3_11310	COG0133	tryptophan synthase activity
VA208B3_11320	COG0134	indole-3-glycerol-phosphate synthase activity
VA208B3_11320	COG0135	phosphoribosylanthranilate isomerase activity
VA208B3_11330	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VA208B3_11340	COG0512	Glutamine amidotransferase of anthranilate synthase
VA208B3_11350	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VA208B3_11360	COG0613	PHP domain protein
VA208B3_11370	COG0009	L-threonylcarbamoyladenylate synthase
VA208B3_11580	COG1187	pseudouridine synthase activity
VA208B3_11590	COG3099	Belongs to the UPF0263 family
VA208B3_11600	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VA208B3_11620	COG0417	DNA replication proofreading
VA208B3_11630	COG2197	response regulator
VA208B3_11640	COG0322	excinuclease ABC activity
VA208B3_11680	COG0019	diaminopimelate decarboxylase activity
VA208B3_11730	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VA208B3_11740	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VA208B3_11750	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VA208B3_11790	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VA208B3_11810	COG0437	4 iron, 4 sulfur cluster binding
VA208B3_11820	COG3301	Polysulphide reductase, NrfD
VA208B3_11830	COG1138	Cytochrome C-type biogenesis protein
VA208B3_11850	COG3088	subunit of a heme lyase
VA208B3_11850	COG4235	cytochrome complex assembly
VA208B3_11870	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VA208B3_11920	COG2989	Protein conserved in bacteria
VA208B3_11930	COG3108	Peptidase M15
VA208B3_11940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VA208B3_11970	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VA208B3_12020	COG1846	Transcriptional regulator
VA208B3_12030	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VA208B3_12040	COG0840	transmembrane signaling receptor activity
VA208B3_12080	COG1448	Aminotransferase
VA208B3_12110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VA208B3_12130	COG0017	Asparaginyl-tRNA synthetase
VA208B3_12140	COG0840	transmembrane signaling receptor activity
VA208B3_12150	COG0720	synthase
VA208B3_12170	COG2200	EAL domain
VA208B3_12180	COG1760	l-serine dehydratase
VA208B3_12190	COG0814	amino acid
VA208B3_12220	COG0784	Response regulator, receiver
VA208B3_12220	COG2205	protein histidine kinase activity
VA208B3_12230	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VA208B3_12260	COG3106	COG3106 Predicted ATPase
VA208B3_12270	COG3768	UPF0283 membrane protein
VA208B3_12290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VA208B3_12580	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VA208B3_12590	COG0456	acetyltransferase
VA208B3_12600	COG0346	lactoylglutathione lyase activity
VA208B3_12810	COG1335	isochorismatase
VA208B3_12850	COG1683	Conserved Protein
VA208B3_12910	COG2226	methyltransferase
VA208B3_13070	COG1609	Transcriptional regulator
VA208B3_13090	COG1175	transmembrane transport
VA208B3_13100	COG0395	ABC-type sugar transport system, permease component
VA208B3_13110	COG2723	6-phospho-beta-galactosidase activity
VA208B3_13120	COG3842	ATPase activity
VA208B3_13130	COG3459	Glycosyltransferase 36 associated
VA208B3_13140	COG2017	converts alpha-aldose to the beta-anomer
VA208B3_13160	COG1609	Transcriptional regulator
VA208B3_13180	COG2273	Hydrolase Family 16
VA208B3_13190	COG0673	inositol 2-dehydrogenase activity
VA208B3_13210	COG2273	Hydrolase Family 16
VA208B3_13210	COG5297	Belongs to the glycosyl hydrolase family 6
VA208B3_13240	COG2755	lipolytic protein G-D-S-L family
VA208B3_13240	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
VA208B3_13330	COG2801	Transposase and inactivated derivatives
VA208B3_13340	COG2801	Transposase and inactivated derivatives
VA208B3_13490	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VA208B3_13520	COG2017	converts alpha-aldose to the beta-anomer
VA208B3_13530	COG1609	Transcriptional regulator
VA208B3_13550	COG1609	Transcriptional regulator
VA208B3_13570	COG2182	Extracellular solute-binding protein
VA208B3_13580	COG1175	transmembrane transport
VA208B3_13590	COG3833	ABC-type maltose transport systems, permease component
VA208B3_13610	COG1874	Beta-galactosidase
VA208B3_13620	COG4580	involved in the transport of maltose and maltodextrins
VA208B3_13630	COG0840	transmembrane signaling receptor activity
VA208B3_13640	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VA208B3_13650	COG1085	galactose-1-phosphate uridylyltransferase
VA208B3_13730	COG1683	Conserved Protein
VA208B3_13900	COG0456	acetyltransferase
VA208B3_14110	COG0456	acetyltransferase
VA208B3_14450	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
VA208B3_14460	COG0583	DNA-binding transcription factor activity
VA208B3_14530	COG0471	metal ion transport
VA208B3_14540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VA208B3_14540	COG4191	Histidine kinase
VA208B3_14560	COG3300	MHYT domain
VA208B3_14560	COG5001	Diguanylate cyclase
VA208B3_14580	COG1280	lysine exporter protein (LysE YggA)
VA208B3_14590	COG1328	CTP reductase activity
VA208B3_14600	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VA208B3_14620	COG0861	Integral membrane protein TerC family
VA208B3_14640	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VA208B3_14660	COG0814	amino acid
VA208B3_14700	COG1132	(ABC) transporter
VA208B3_14710	COG1132	(ABC) transporter
VA208B3_14760	COG0443	Heat shock 70 kDa protein
VA208B3_14770	COG0443	Heat shock 70 kDa protein
VA208B3_14850	COG0243	molybdopterin cofactor binding
VA208B3_14860	COG0437	4 iron, 4 sulfur cluster binding
VA208B3_14870	COG3302	dmso reductase anchor subunit
VA208B3_14900	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VA208B3_14910	COG1643	Atp-dependent helicase
VA208B3_14940	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VA208B3_14960	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VA208B3_14970	COG1215	transferase activity, transferring glycosyl groups
VA208B3_14980	COG0438	transferase activity, transferring glycosyl groups
VA208B3_15060	COG2204	response regulator
VA208B3_15120	COG1793	dna ligase
VA208B3_15140	COG0534	Mate efflux family protein
VA208B3_15150	COG0307	riboflavin synthase, alpha
VA208B3_15170	COG3001	Fructosamine kinase
VA208B3_15180	COG2201	protein-glutamate methylesterase activity
VA208B3_15190	COG3706	GGDEF domain
VA208B3_15210	COG0791	NLP P60 protein
VA208B3_15220	COG3290	protein histidine kinase activity
VA208B3_15220	COG0840	transmembrane signaling receptor activity
VA208B3_15250	COG3706	GGDEF domain
VA208B3_15330	COG3148	PFAM DTW domain containing protein
VA208B3_15340	COG1940	carbohydrate kinase activity
VA208B3_15360	COG0303	'Molybdopterin
VA208B3_15370	COG0746	molybdenum cofactor guanylyltransferase activity
VA208B3_15380	COG3842	ATPase activity
VA208B3_15410	COG2204	response regulator
VA208B3_15420	COG4191	Histidine kinase
VA208B3_15430	COG0488	(ABC) transporter
VA208B3_15440	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VA208B3_15480	COG3381	protein complex oligomerization
VA208B3_15500	COG0243	molybdopterin cofactor binding
VA208B3_15500	COG3383	formate dehydrogenase (NAD+) activity
VA208B3_15510	COG0437	4 iron, 4 sulfur cluster binding
VA208B3_15550	COG4282	regulation of fungal-type cell wall biogenesis
VA208B3_15560	COG0004	ammonium transporteR
VA208B3_15580	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VA208B3_15590	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VA208B3_15610	COG1177	transmembrane transport
VA208B3_15630	COG3842	ATPase activity
VA208B3_15670	COG0037	tRNA processing
VA208B3_15680	COG0589	response to stress
VA208B3_15690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VA208B3_15720	COG2217	Heavy metal translocating P-type atpase
VA208B3_15740	COG2010	Cytochrome c
VA208B3_15770	COG3278	Belongs to the heme-copper respiratory oxidase family
VA208B3_15800	COG2205	protein histidine kinase activity
VA208B3_15800	COG0784	Response regulator, receiver
VA208B3_15940	COG3120	sequence-specific DNA binding
VA208B3_15950	COG1067	ATP-dependent peptidase activity
VA208B3_15960	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VA208B3_15990	COG0488	(ABC) transporter
VA208B3_16010	COG0116	Belongs to the methyltransferase superfamily
VA208B3_16010	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VA208B3_16030	COG0167	dihydroorotate dehydrogenase activity
VA208B3_16040	COG2902	Dehydrogenase
VA208B3_16050	COG0308	aminopeptidase N
VA208B3_16080	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VA208B3_16090	COG1956	GAF domain-containing protein
VA208B3_16100	COG1132	(ABC) transporter
VA208B3_16110	COG2995	paraquat-inducible protein a
VA208B3_16120	COG3008	intermembrane lipid transfer
VA208B3_16130	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VA208B3_16130	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
VA208B3_16170	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VA208B3_16180	COG1666	GTP binding
VA208B3_16200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VA208B3_16210	COG4597	amino acid ABC transporter
VA208B3_16220	COG0765	amino acid transport
VA208B3_16230	COG1126	abc transporter atp-binding protein
VA208B3_16240	COG0670	Belongs to the BI1 family
VA208B3_16260	COG2920	part of a sulfur-relay system
VA208B3_16270	COG1254	Belongs to the acylphosphatase family
VA208B3_16280	COG0840	transmembrane signaling receptor activity
VA208B3_16290	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VA208B3_16330	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VA208B3_16340	COG0602	queuosine metabolic process
VA208B3_16350	COG0561	phosphatase activity
VA208B3_16400	COG2828	Protein conserved in bacteria
VA208B3_16420	COG0372	Belongs to the citrate synthase family
VA208B3_16430	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VA208B3_16490	COG0730	response to heat
VA208B3_16530	COG0457	Tetratricopeptide repeat
VA208B3_16670	COG4790	Type iii secretion
VA208B3_16680	COG4794	Type iii secretion
VA208B3_16690	COG4791	protein targeting
VA208B3_16700	COG4792	protein secretion
VA208B3_16720	COG1073	alpha beta
VA208B3_16730	COG1073	alpha beta
VA208B3_16790	COG3177	Filamentation induced by cAMP protein fic
VA208B3_16830	COG4669	(LipO)protein
VA208B3_16970	COG1012	belongs to the aldehyde dehydrogenase family
VA208B3_16980	COG3284	Transcriptional regulator
VA208B3_17010	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VA208B3_17020	COG0363	glucosamine-6-phosphate deaminase activity
VA208B3_17030	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VA208B3_17040	COG4565	transcriptional regulatory protein
VA208B3_17050	COG3290	protein histidine kinase activity
VA208B3_17080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VA208B3_17110	COG1858	cytochrome C peroxidase
VA208B3_17120	COG0527	aspartate kinase activity
VA208B3_17130	COG0662	Cupin 2, conserved barrel domain protein
VA208B3_17140	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VA208B3_17150	COG0456	acetyltransferase
VA208B3_17160	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VA208B3_17200	COG4176	ABC-type proline glycine betaine transport system permease component
VA208B3_17210	COG2113	Glycine betaine
VA208B3_17250	COG1028	Short-chain dehydrogenase reductase Sdr
VA208B3_17270	COG0745	RESPONSE REGULATOR receiver
VA208B3_17280	COG0642	Histidine kinase
VA208B3_17290	COG1368	sulfuric ester hydrolase activity
VA208B3_17340	COG1115	amino acid carrier protein
VA208B3_17360	COG1280	lysine exporter protein (LysE YggA)
VA208B3_17370	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VA208B3_17380	COG1560	Kdo2-lipid A biosynthetic process
VA208B3_17390	COG0531	amino acid
VA208B3_17410	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
VA208B3_17420	COG3063	Type IV pilus biogenesis stability protein PilW
VA208B3_17480	COG0110	maltose O-acetyltransferase activity
VA208B3_17520	COG2315	Protein conserved in bacteria
VA208B3_17530	COG1846	Transcriptional regulator
VA208B3_17560	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VA208B3_17590	COG2200	EAL domain
VA208B3_17590	COG2771	luxR family
VA208B3_17600	COG1227	inorganic diphosphatase activity
VA208B3_17610	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VA208B3_17620	COG1012	belongs to the aldehyde dehydrogenase family
VA208B3_17630	COG2957	Belongs to the agmatine deiminase family
VA208B3_17650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VA208B3_17660	COG1012	belongs to the aldehyde dehydrogenase family
VA208B3_17670	COG1396	sequence-specific DNA binding
VA208B3_17670	COG1917	Cupin 2, conserved barrel domain protein
VA208B3_17680	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
VA208B3_17690	COG0174	glutamine synthetase
VA208B3_17700	COG1757	Na H antiporter
VA208B3_17740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VA208B3_17750	COG1280	lysine exporter protein (LysE YggA)
VA208B3_17810	COG0625	glutathione transferase activity
VA208B3_17830	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VA208B3_17860	COG2195	Cleaves the N-terminal amino acid of tripeptides
VA208B3_17880	COG0601	transmembrane transport
VA208B3_17890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VA208B3_17900	COG0444	Belongs to the ABC transporter superfamily
VA208B3_17930	COG3291	Pkd domain containing protein
VA208B3_17950	COG1177	transmembrane transport
VA208B3_17960	COG1176	ABC-type spermidine putrescine transport system, permease component I
VA208B3_17970	COG3842	ATPase activity
VA208B3_17980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VA208B3_17990	COG2423	ornithine cyclodeaminase activity
VA208B3_18020	COG3938	Belongs to the proline racemase family
VA208B3_18080	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
VA208B3_18090	COG1451	nucleotide metabolic process
VA208B3_18100	COG3475	LICD family
VA208B3_18110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VA208B3_18120	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VA208B3_18160	COG0583	DNA-binding transcription factor activity
VA208B3_18200	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
VA208B3_18210	COG4139	cobalamin transport
VA208B3_18220	COG2988	succinylglutamate desuccinylase activity
VA208B3_18240	COG2062	phosphohistidine phosphatase, SixA
VA208B3_18260	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VA208B3_18270	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VA208B3_18290	COG1823	symporter activity
VA208B3_18300	COG2925	Exonuclease
VA208B3_18310	COG1380	Effector of murein hydrolase LrgA
VA208B3_18320	COG1346	cytolysis
VA208B3_18330	COG0295	cytidine deaminase activity
VA208B3_18340	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VA208B3_18350	COG0500	methyltransferase
VA208B3_18370	COG0776	regulation of translation
VA208B3_18390	COG0072	phenylalanine-tRNA ligase activity
VA208B3_18390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VA208B3_18400	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VA208B3_18410	COG3706	GGDEF domain
VA208B3_18470	COG0393	Putative heavy-metal-binding
VA208B3_18490	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VA208B3_18510	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VA208B3_18540	COG2188	Transcriptional regulator
VA208B3_18550	COG1228	amidohydrolase
VA208B3_18560	COG0010	Belongs to the arginase family
VA208B3_18570	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VA208B3_18580	COG2986	histidine ammonia-lyase
VA208B3_18610	COG0277	FAD linked oxidase domain protein
VA208B3_18610	COG0247	lactate metabolic process
VA208B3_18680	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VA208B3_18710	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
VA208B3_18720	COG1643	Atp-dependent helicase
VA208B3_18730	COG0281	malic enzyme
VA208B3_18740	COG2949	membrane
VA208B3_18750	COG0471	metal ion transport
VA208B3_18800	COG0492	ferredoxin-NADP+ reductase activity
VA208B3_18810	COG4988	ABC transporter
VA208B3_18820	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VA208B3_18830	COG3048	D-serine ammonia-lyase activity
VA208B3_18840	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VA208B3_18860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VA208B3_18860	COG4191	Histidine kinase
VA208B3_18890	COG3070	regulator of competence-specific genes
VA208B3_18920	COG2431	L-lysine efflux transmembrane transporter activity
VA208B3_18940	COG0076	glutamate decarboxylase activity
VA208B3_18950	COG1737	Transcriptional regulator
VA208B3_18970	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VA208B3_18980	COG2985	domain, Protein
VA208B3_18980	COG3273	potassium ion transport
VA208B3_18990	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VA208B3_19020	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VA208B3_19050	COG4181	ATPase activity
VA208B3_19060	COG0534	Mate efflux family protein
VA208B3_19070	COG0702	epimerase
VA208B3_19080	COG3005	denitrification pathway
VA208B3_19140	COG2814	Major facilitator Superfamily
VA208B3_19150	COG1187	pseudouridine synthase activity
VA208B3_19160	COG1061	Type III restriction enzyme res subunit
VA208B3_19200	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VA208B3_19290	COG0493	'glutamate synthase
VA208B3_19310	COG0398	Pfam SNARE associated Golgi protein
VA208B3_19320	COG4134	Bacterial extracellular solute-binding protein
VA208B3_19330	COG4135	transport system, permease component
VA208B3_19340	COG4136	ATPase activity
VA208B3_19350	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VA208B3_19370	COG3604	Transcriptional regulator
VA208B3_19380	COG1151	hydroxylamine reductase activity
VA208B3_19390	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VA208B3_19410	COG0564	pseudouridine synthase activity
VA208B3_19430	COG0733	neurotransmitter:sodium symporter activity
VA208B3_19450	COG0626	cystathionine gamma-synthase activity
VA208B3_19460	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
VA208B3_19470	COG5380	lipid catabolic process
VA208B3_19480	COG2818	Glycosylase
VA208B3_19510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VA208B3_19520	COG1983	PspC domain protein
VA208B3_19540	COG1842	Phage shock protein A
VA208B3_19550	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VA208B3_19580	COG4171	peptide transport system, permease
VA208B3_19600	COG4172	Belongs to the ABC transporter superfamily
VA208B3_19620	COG1227	inorganic diphosphatase activity
VA208B3_19650	COG0243	molybdopterin cofactor binding
VA208B3_19660	COG3005	denitrification pathway
VA208B3_19670	COG4459	periplasmic nitrate reductase
VA208B3_19680	COG0390	transport system, permease component
VA208B3_19700	COG2116	formate transmembrane transporter activity
VA208B3_19750	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VA208B3_19760	COG1435	thymidine kinase activity
VA208B3_19770	COG0215	cysteine-tRNA ligase activity
VA208B3_19780	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VA208B3_19790	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VA208B3_19800	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VA208B3_19810	COG3012	SEC-C Motif Domain Protein
VA208B3_19820	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VA208B3_19820	COG0140	phosphoribosyl-ATP diphosphatase activity
VA208B3_19830	COG0107	imidazoleglycerol-phosphate synthase activity
VA208B3_19840	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VA208B3_19850	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VA208B3_19860	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VA208B3_19860	COG0131	Imidazoleglycerol-phosphate dehydratase
VA208B3_19870	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VA208B3_19880	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VA208B3_19890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VA208B3_19930	COG1757	Na H antiporter
VA208B3_19950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VA208B3_19970	COG0482	sulfurtransferase activity
VA208B3_19980	COG2915	High frequency lysogenization protein hflD homolog
VA208B3_19990	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VA208B3_20030	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VA208B3_20060	COG0300	oxidoreductase activity
VA208B3_20080	COG0501	Belongs to the peptidase M48B family
VA208B3_20100	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VA208B3_20120	COG0156	8-amino-7-oxononanoate synthase activity
VA208B3_20130	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VA208B3_20140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VA208B3_20150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VA208B3_20180	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VA208B3_20190	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VA208B3_20200	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VA208B3_20210	COG1674	ftsk spoiiie
VA208B3_20230	COG0686	Belongs to the AlaDH PNT family
VA208B3_20250	COG0583	DNA-binding transcription factor activity
VA208B3_20280	COG3568	Endonuclease Exonuclease Phosphatase
VA208B3_20330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VA208B3_20340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VA208B3_20350	COG0840	transmembrane signaling receptor activity
VA208B3_20370	COG5002	protein histidine kinase activity
VA208B3_20370	COG0784	Response regulator, receiver
VA208B3_20390	COG0754	glutathionylspermidine amidase activity
VA208B3_20410	COG3766	membrane
VA208B3_20430	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VA208B3_20440	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VA208B3_20450	COG2885	chlorophyll binding
VA208B3_20460	COG0823	Involved in the tonB-independent uptake of proteins
VA208B3_20490	COG0811	peptide transport
VA208B3_20500	COG0824	Thioesterase
VA208B3_20520	COG1294	oxidase, subunit
VA208B3_20530	COG1271	oxidase subunit
VA208B3_20540	COG2255	four-way junction helicase activity
VA208B3_20550	COG0632	four-way junction helicase activity
VA208B3_20560	COG0840	transmembrane signaling receptor activity
VA208B3_20580	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VA208B3_20590	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VA208B3_20600	COG1801	Protein of unknown function DUF72
VA208B3_20610	COG4106	trans-aconitate 2-methyltransferase activity
VA208B3_20620	COG0500	methyltransferase
VA208B3_20630	COG4067	protein conserved in archaea
VA208B3_20630	COG0189	ligase activity
VA208B3_20670	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VA208B3_20680	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VA208B3_20690	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
VA208B3_20700	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VA208B3_20710	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VA208B3_20720	COG0745	RESPONSE REGULATOR receiver
VA208B3_20730	COG3381	protein complex oligomerization
VA208B3_20740	COG1609	Transcriptional regulator
VA208B3_20760	COG3070	regulator of competence-specific genes
VA208B3_20800	COG0297	glycogen (starch) synthase activity
VA208B3_20810	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VA208B3_20820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VA208B3_20840	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VA208B3_20860	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VA208B3_20870	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VA208B3_20880	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VA208B3_20900	COG0542	response to heat
VA208B3_20910	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VA208B3_20920	COG1278	Cold shock
VA208B3_20940	COG1187	pseudouridine synthase activity
VA208B3_20950	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VA208B3_20960	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VA208B3_20970	COG1199	ATP-dependent helicase activity
VA208B3_20980	COG0730	response to heat
VA208B3_20990	COG3923	Primosomal replication protein n
VA208B3_21010	COG0708	Exodeoxyribonuclease III
VA208B3_21090	COG1882	Formate acetyltransferase
VA208B3_21110	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VA208B3_21130	COG3013	Belongs to the UPF0304 family
VA208B3_21140	COG2766	serine protein kinase
VA208B3_21150	COG2718	Belongs to the UPF0229 family
VA208B3_21160	COG2719	SpoVR family
VA208B3_21170	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VA208B3_21190	COG1663	tetraacyldisaccharide 4'-kinase activity
VA208B3_21200	COG1132	(ABC) transporter
VA208B3_21210	COG2333	competence protein COMEC
VA208B3_21210	COG0658	competence protein
VA208B3_21230	COG4591	ABC-type transport system involved in lipoprotein release permease component
VA208B3_21240	COG1136	(ABC) transporter
VA208B3_21250	COG4591	ABC-type transport system involved in lipoprotein release permease component
VA208B3_21270	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VA208B3_21300	COG1252	NADH dehydrogenase
VA208B3_21310	COG3150	esterase
VA208B3_21360	COG0537	adenosine 5'-monophosphoramidase activity
VA208B3_21410	COG0516	GMP reductase activity
VA208B3_21410	COG0517	IMP dehydrogenase activity
VA208B3_21420	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VA208B3_21430	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VA208B3_21440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VA208B3_21450	COG2199	diguanylate cyclase activity
VA208B3_21480	COG3126	Type III secretion system lipoprotein chaperone (YscW)
VA208B3_21490	COG1946	Acyl-CoA thioesterase
VA208B3_21510	COG1522	sequence-specific DNA binding
VA208B3_21560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VA208B3_21570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VA208B3_21610	COG0477	Major facilitator Superfamily
VA208B3_21630	COG2855	membrane
VA208B3_21670	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VA208B3_21680	COG0596	Alpha beta hydrolase
VA208B3_21690	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VA208B3_21700	COG1169	isochorismate synthase
VA208B3_21710	COG0436	Aminotransferase
VA208B3_21720	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VA208B3_21730	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VA208B3_21760	COG1555	photosystem II stabilization
VA208B3_21770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VA208B3_21780	COG0776	regulation of translation
VA208B3_21790	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VA208B3_21800	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VA208B3_21820	COG0544	peptidyl-prolyl cis-trans isomerase activity
VA208B3_21850	COG2204	response regulator
VA208B3_21870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VA208B3_21880	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VA208B3_21890	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VA208B3_21900	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VA208B3_21930	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VA208B3_21940	COG0569	domain protein
VA208B3_21950	COG0513	Belongs to the DEAD box helicase family
VA208B3_21960	COG1253	flavin adenine dinucleotide binding
VA208B3_22030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VA208B3_22040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VA208B3_22060	COG0318	PFAM AMP-dependent synthetase and ligase
VA208B3_22070	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VA208B3_22080	COG1216	Glycosyl transferase, family 2
VA208B3_22090	COG2986	histidine ammonia-lyase
VA208B3_22140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VA208B3_22160	COG1028	Short-chain dehydrogenase reductase Sdr
VA208B3_22200	COG3550	peptidyl-serine autophosphorylation
VA208B3_22210	COG1396	sequence-specific DNA binding
VA208B3_22220	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VA208B3_22430	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VA208B3_22440	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VA208B3_22450	COG0583	DNA-binding transcription factor activity
VA208B3_22460	COG2951	lytic endotransglycosylase activity
VA208B3_22470	COG3100	YcgL domain-containing protein
VA208B3_22480	COG0850	regulation of cytokinetic process
VA208B3_22490	COG2894	cell division
VA208B3_22500	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VA208B3_22510	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VA208B3_22520	COG0318	PFAM AMP-dependent synthetase and ligase
VA208B3_22530	COG2267	carboxylic ester hydrolase activity
VA208B3_22560	COG1214	PFAM Peptidase M22, glycoprotease
VA208B3_22570	COG1199	ATP-dependent helicase activity
VA208B3_22580	COG0788	formyltetrahydrofolate deformylase activity
VA208B3_22590	COG3102	Protein conserved in bacteria
VA208B3_22600	COG0018	arginyl-trna synthetase
VA208B3_22640	COG1918	ferrous iron import across plasma membrane
VA208B3_22660	COG4977	sequence-specific DNA binding
VA208B3_22670	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VA208B3_22680	COG1121	(ABC) transporter
VA208B3_22690	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VA208B3_22700	COG0121	glutamine amidotransferase
VA208B3_22710	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VA208B3_22720	COG1960	acyl-CoA dehydrogenase activity
VA208B3_22740	COG0456	acetyltransferase
VA208B3_22780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VA208B3_22790	COG0328	RNA-DNA hybrid ribonuclease activity
VA208B3_22800	COG2226	methyltransferase
VA208B3_22810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VA208B3_22820	COG1388	LysM domain
VA208B3_22820	COG0741	lytic transglycosylase activity
VA208B3_22840	COG3021	interspecies interaction between organisms
VA208B3_22850	COG0347	Belongs to the P(II) protein family
VA208B3_22870	COG0037	tRNA processing
VA208B3_22880	COG0825	malonyl-CoA metabolic process
VA208B3_22890	COG0587	DNA-directed DNA polymerase activity
VA208B3_22900	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VA208B3_22910	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VA208B3_22920	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VA208B3_22930	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VA208B3_22940	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VA208B3_22950	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VA208B3_22970	COG0750	zinc metalloprotease
VA208B3_22980	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VA208B3_22990	COG0575	Belongs to the CDS family
VA208B3_23000	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VA208B3_23010	COG0233	cytoplasmic translational termination
VA208B3_23020	COG0528	UMP kinase activity
VA208B3_23030	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VA208B3_23040	COG0052	Belongs to the universal ribosomal protein uS2 family
VA208B3_23050	COG0024	Methionine aminopeptidase
VA208B3_23060	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VA208B3_23080	COG0564	pseudouridine synthase activity
VA208B3_23090	COG3098	single-species biofilm formation
VA208B3_23130	COG1671	Belongs to the UPF0178 family
VA208B3_23140	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VA208B3_23160	COG0254	rRNA binding
VA208B3_23170	COG1720	tRNA m6t6A37 methyltransferase activity
VA208B3_23180	COG0442	prolyl-tRNA aminoacylation
VA208B3_23220	COG0733	neurotransmitter:sodium symporter activity
VA208B3_23260	COG0514	ATP-dependent DNA helicase (RecQ)
VA208B3_23270	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VA208B3_23300	COG1477	protein flavinylation
VA208B3_23310	COG2871	sodium ion transport
VA208B3_23320	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VA208B3_23330	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VA208B3_23340	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VA208B3_23350	COG1805	sodium ion transport
VA208B3_23360	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VA208B3_23380	COG0271	Belongs to the BolA IbaG family
VA208B3_23390	COG2813	Specifically methylates the guanine in position
VA208B3_23400	COG3056	Lipoprotein
VA208B3_23440	COG1595	DNA-templated transcription, initiation
VA208B3_23490	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VA208B3_23500	COG0693	protein deglycase activity
VA208B3_23510	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VA208B3_23520	COG3706	GGDEF domain
VA208B3_23530	COG2166	iron-sulfur cluster assembly
VA208B3_23540	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VA208B3_23550	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VA208B3_23570	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VA208B3_23570	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VA208B3_23590	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VA208B3_23600	COG1074	ATP-dependent DNA helicase activity
VA208B3_23610	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VA208B3_23650	COG3141	response to X-ray
VA208B3_23660	COG2171	N-acyltransferase activity
VA208B3_23670	COG0584	glycerophosphoryl diester phosphodiesterase
VA208B3_23680	COG2271	Major facilitator Superfamily
VA208B3_23690	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VA208B3_23700	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VA208B3_23710	COG1349	DNA-binding transcription factor activity
VA208B3_23720	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VA208B3_23730	COG0598	Magnesium transport protein CorA
VA208B3_23770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VA208B3_23780	COG1609	Transcriptional regulator
VA208B3_23790	COG2211	Major facilitator Superfamily
VA208B3_23820	COG2017	converts alpha-aldose to the beta-anomer
VA208B3_23830	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VA208B3_23850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VA208B3_23860	COG1609	Transcriptional regulator
VA208B3_23870	COG3250	beta-galactosidase activity
VA208B3_23880	COG2731	YhcH YjgK YiaL family protein
VA208B3_23890	COG0531	amino acid
VA208B3_24040	COG4964	Belongs to the GSP D family
VA208B3_24070	COG0583	DNA-binding transcription factor activity
VA208B3_24150	COG1022	Amp-dependent synthetase and ligase
VA208B3_24170	COG0583	DNA-binding transcription factor activity
VA208B3_24180	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VA208B3_24190	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VA208B3_24210	COG0560	Phosphoserine phosphatase
VA208B3_24230	COG0813	purine-nucleoside phosphorylase activity
VA208B3_24240	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VA208B3_24250	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VA208B3_24260	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VA208B3_24270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VA208B3_24280	COG0084	hydrolase, TatD family'
VA208B3_24300	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VA208B3_24340	COG3153	acetyltransferase
VA208B3_24350	COG3154	lipid carrier protein
VA208B3_24370	COG0826	peptidase U32
VA208B3_24380	COG0826	peptidase U32
VA208B3_24390	COG0534	Mate efflux family protein
VA208B3_24420	COG1185	polyribonucleotide nucleotidyltransferase activity
VA208B3_24430	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VA208B3_24440	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VA208B3_24450	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VA208B3_24460	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VA208B3_24470	COG0195	Participates in both transcription termination and antitermination
VA208B3_24480	COG0779	Required for maturation of 30S ribosomal subunits
VA208B3_24490	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VA208B3_24500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VA208B3_24510	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VA208B3_24520	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VA208B3_24530	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VA208B3_24540	COG1534	Rna-binding protein
VA208B3_24550	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VA208B3_24560	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VA208B3_24570	COG2027	D-alanyl-D-alanine carboxypeptidase
VA208B3_24590	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VA208B3_24600	COG0739	heme binding
VA208B3_24610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VA208B3_24630	COG0316	Belongs to the HesB IscA family
VA208B3_24640	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VA208B3_24650	COG0628	permease
VA208B3_24660	COG2813	Specifically methylates the guanine in position
VA208B3_24670	COG0784	Response regulator, receiver
VA208B3_24670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VA208B3_24670	COG2205	protein histidine kinase activity
VA208B3_24670	COG2198	Histidine kinase
VA208B3_24680	COG0747	negative chemotaxis
VA208B3_24700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VA208B3_24710	COG0444	Belongs to the ABC transporter superfamily
VA208B3_24720	COG4608	Belongs to the ABC transporter superfamily
VA208B3_24740	COG2971	BadF BadG BcrA BcrD
VA208B3_24770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VA208B3_24780	COG3842	ATPase activity
VA208B3_24800	COG1840	ABC-type Fe3 transport system, periplasmic component
VA208B3_24810	COG0004	ammonium transporteR
VA208B3_24830	COG3112	Uncharacterised protein family (UPF0231)
VA208B3_24840	COG1049	propionate catabolic process, 2-methylcitrate cycle
VA208B3_24850	COG1752	Esterase of the alpha-beta hydrolase superfamily
VA208B3_24860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VA208B3_24870	COG1643	Atp-dependent helicase
VA208B3_24880	COG1489	DNA binding
VA208B3_24900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VA208B3_24920	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VA208B3_24930	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VA208B3_24940	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VA208B3_24950	COG1560	Kdo2-lipid A biosynthetic process
VA208B3_24960	COG0842	Transport permease protein
VA208B3_24970	COG1131	(ABC) transporter
VA208B3_24980	COG0659	secondary active sulfate transmembrane transporter activity
VA208B3_24990	COG0288	reversible hydration of carbon dioxide
VA208B3_25020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VA208B3_25030	COG0508	dehydrogenase complex catalyzes the overall conversion of
VA208B3_25040	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VA208B3_25050	COG2186	Transcriptional regulator
VA208B3_25070	COG0157	Belongs to the NadC ModD family
VA208B3_25090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VA208B3_25100	COG1459	type II secretion system
VA208B3_25120	COG0237	dephospho-CoA kinase activity
VA208B3_25130	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VA208B3_25140	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VA208B3_25150	COG0335	large ribosomal subunit rRNA binding
VA208B3_25160	COG0336	Belongs to the RNA methyltransferase TrmD family
VA208B3_25170	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VA208B3_25180	COG0228	four-way junction DNA binding
VA208B3_25190	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VA208B3_25200	COG4137	Cytochrome C assembly protein
VA208B3_25210	COG4536	flavin adenine dinucleotide binding
VA208B3_25220	COG1854	S-ribosylhomocysteine lyase activity
VA208B3_25240	COG2918	glutathione biosynthetic process
VA208B3_25250	COG0612	Peptidase, M16
VA208B3_25260	COG1238	metal cluster binding
VA208B3_25280	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VA208B3_25290	COG0511	ligase activity, forming carbon-carbon bonds
VA208B3_25290	COG5016	pyruvate
VA208B3_25300	COG3630	sodium ion export across plasma membrane
VA208B3_25320	COG0527	aspartate kinase activity
VA208B3_25330	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VA208B3_25340	COG2137	regulation of response to DNA damage stimulus
VA208B3_25350	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VA208B3_25360	COG1546	Belongs to the CinA family
VA208B3_25370	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VA208B3_25380	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VA208B3_25400	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VA208B3_25410	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VA208B3_25420	COG0585	pseudouridine synthase activity
VA208B3_25430	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VA208B3_25440	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VA208B3_25450	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VA208B3_25460	COG0148	phosphopyruvate hydratase activity
VA208B3_25470	COG0504	CTP synthase activity
VA208B3_25480	COG3956	TIGRFAM MazG family protein
VA208B3_25490	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VA208B3_25500	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VA208B3_25520	COG0736	holo-[acyl-carrier-protein] synthase activity
VA208B3_25530	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VA208B3_25540	COG1381	Involved in DNA repair and RecF pathway recombination
VA208B3_25550	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VA208B3_25560	COG0571	ribonuclease III activity
VA208B3_25580	COG0481	GTPase activity
VA208B3_25590	COG3086	response to oxidative stress
VA208B3_25610	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
VA208B3_25620	COG1595	DNA-templated transcription, initiation
VA208B3_25630	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VA208B3_25650	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VA208B3_25660	COG0354	folic acid binding
VA208B3_25690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VA208B3_25700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VA208B3_25710	COG3079	Belongs to the UPF0149 family
VA208B3_25720	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VA208B3_25730	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VA208B3_25740	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VA208B3_25750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VA208B3_25770	COG0583	DNA-binding transcription factor activity
VA208B3_25790	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VA208B3_25800	COG0668	transmembrane transport
VA208B3_25810	COG0191	fructose-bisphosphate aldolase activity
VA208B3_25820	COG0126	phosphoglycerate kinase activity
VA208B3_25830	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VA208B3_25840	COG4771	TonB-dependent receptor
VA208B3_25850	COG0583	DNA-binding transcription factor activity
VA208B3_25860	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VA208B3_25880	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VA208B3_25900	COG3091	SprT-like family
VA208B3_25910	COG2356	endonuclease I
VA208B3_25920	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VA208B3_25930	COG0189	ligase activity
VA208B3_25940	COG1678	Uncharacterized ACR, COG1678
VA208B3_25950	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VA208B3_25980	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VA208B3_25990	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VA208B3_26000	COG0762	integral membrane protein
VA208B3_26010	COG1872	DUF167
VA208B3_26030	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VA208B3_26040	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VA208B3_26050	COG2066	Belongs to the glutaminase family
VA208B3_26070	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VA208B3_26090	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VA208B3_26100	COG0741	lytic transglycosylase activity
VA208B3_26120	COG1012	belongs to the aldehyde dehydrogenase family
VA208B3_26130	COG3437	response regulator, receiver
VA208B3_26150	COG3394	polysaccharide catabolic process
VA208B3_26160	COG1486	melibiose metabolic process
VA208B3_26170	COG1447	Phosphotransferase system cellobiose-specific component IIA
VA208B3_26180	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VA208B3_26200	COG0726	polysaccharide deacetylase
VA208B3_26210	COG1028	Short-chain dehydrogenase reductase Sdr
VA208B3_26240	COG0795	lipopolysaccharide-transporting ATPase activity
VA208B3_26250	COG0795	lipopolysaccharide-transporting ATPase activity
VA208B3_26260	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VA208B3_26270	COG2927	DNA polymerase III (CHI subunit)
VA208B3_26280	COG0525	valine-tRNA ligase activity
VA208B3_26300	COG0456	acetyltransferase
VA208B3_26330	COG2235	arginine
VA208B3_26340	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VA208B3_26350	COG0540	Belongs to the ATCase OTCase family
VA208B3_26360	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VA208B3_26370	COG0251	oxidation-reduction process
VA208B3_26380	COG0204	Acyl-transferase
VA208B3_26390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VA208B3_26400	COG5007	Belongs to the BolA IbaG family
VA208B3_26420	COG2854	intermembrane phospholipid transfer
VA208B3_26430	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VA208B3_26440	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VA208B3_26450	COG1127	ABC transporter
VA208B3_26470	COG0517	IMP dehydrogenase activity
VA208B3_26470	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VA208B3_26490	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VA208B3_26500	COG1137	ATPase activity
VA208B3_26520	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VA208B3_26530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VA208B3_26540	COG1660	Displays ATPase and GTPase activities
VA208B3_26550	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VA208B3_26560	COG2239	Acts as a magnesium transporter
VA208B3_26570	COG0312	modulator of DNA gyrase
VA208B3_26580	COG3028	Belongs to the UPF0307 family
VA208B3_26590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VA208B3_26600	COG0564	pseudouridine synthase activity
VA208B3_26620	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VA208B3_26630	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VA208B3_26640	COG0312	modulator of DNA gyrase
VA208B3_26650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VA208B3_26660	COG3164	Protein of unknown function
VA208B3_26680	COG0424	maF-like protein
VA208B3_26690	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VA208B3_26700	COG1792	Involved in formation and maintenance of cell shape
VA208B3_26710	COG1077	Cell shape determining protein MreB Mrl
VA208B3_26780	COG2165	general secretion pathway protein
VA208B3_26800	COG1459	type II secretion system
VA208B3_26810	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VA208B3_26830	COG3267	Type II secretory pathway component ExeA
VA208B3_26830	COG3409	Peptidoglycan-binding domain 1 protein
VA208B3_26890	COG2199	diguanylate cyclase activity
VA208B3_26890	COG2200	EAL domain
VA208B3_26900	COG0629	single-stranded DNA binding
VA208B3_26930	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VA208B3_26950	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VA208B3_26960	COG0527	aspartate kinase activity
VA208B3_26970	COG0646	methionine synthase
VA208B3_26970	COG1410	methionine synthase
VA208B3_26990	COG0175	sulfate reduction
VA208B3_27000	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VA208B3_27010	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VA208B3_27050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VA208B3_27350	COG0735	belongs to the Fur family
VA208B3_27370	COG0166	Belongs to the GPI family
VA208B3_27380	COG0432	Pfam Uncharacterised protein family UPF0047
VA208B3_27400	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VA208B3_27430	COG0359	binds to the 23S rRNA
VA208B3_27450	COG2965	DNA replication, synthesis of RNA primer
VA208B3_27460	COG0360	Binds together with S18 to 16S ribosomal RNA
VA208B3_27470	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VA208B3_27480	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VA208B3_27500	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VA208B3_27510	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VA208B3_27570	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VA208B3_27590	COG0678	peroxiredoxin activity
VA208B3_27590	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VA208B3_27600	COG0165	Argininosuccinate lyase
VA208B3_27600	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VA208B3_27610	COG0137	argininosuccinate synthase activity
VA208B3_27620	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VA208B3_27630	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VA208B3_27640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VA208B3_27650	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VA208B3_27670	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VA208B3_27680	COG0460	homoserine dehydrogenase
VA208B3_27680	COG0527	aspartate kinase activity
VA208B3_27690	COG0626	cystathionine gamma-synthase activity
VA208B3_27710	COG0281	malic enzyme
VA208B3_27730	COG2906	2 iron, 2 sulfur cluster binding
VA208B3_27740	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VA208B3_27750	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VA208B3_27760	COG0049	tRNA binding
VA208B3_27780	COG2168	tRNA wobble position uridine thiolation
VA208B3_27790	COG2923	Belongs to the DsrF TusC family
VA208B3_27800	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VA208B3_27810	COG2964	Protein conserved in bacteria
VA208B3_27820	COG0545	Peptidyl-prolyl cis-trans isomerase
VA208B3_27840	COG2900	Belongs to the SlyX family
VA208B3_27850	COG1446	asparaginase
VA208B3_27860	COG1047	Peptidyl-prolyl cis-trans
VA208B3_27890	COG2249	NAD(P)H dehydrogenase (quinone) activity
VA208B3_27900	COG0488	(ABC) transporter
VA208B3_27920	COG0429	hydrolase of the alpha beta-hydrolase fold
VA208B3_27930	COG3089	Belongs to the UPF0270 family
VA208B3_27940	COG3954	Phosphoribulokinase
VA208B3_27950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VA208B3_27970	COG1012	belongs to the aldehyde dehydrogenase family
VA208B3_27990	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VA208B3_28000	COG0512	Glutamine amidotransferase of anthranilate synthase
VA208B3_28030	COG0180	Tryptophanyl-tRNA synthetase
VA208B3_28040	COG0546	phosphoglycolate phosphatase activity
VA208B3_28050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VA208B3_28060	COG0557	exoribonuclease II activity
VA208B3_28070	COG1959	2 iron, 2 sulfur cluster binding
VA208B3_28080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VA208B3_28080	COG1017	nitric oxide dioxygenase activity
VA208B3_28090	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VA208B3_28100	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VA208B3_28110	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VA208B3_28120	COG0330	HflC and HflK could
VA208B3_28130	COG0330	HflC and HflK could
VA208B3_28140	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VA208B3_28160	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VA208B3_28170	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VA208B3_28190	COG0802	atpase or kinase
VA208B3_28200	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VA208B3_28210	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VA208B3_28220	COG1162	GTPase activity
VA208B3_28230	COG0688	phosphatidylethanolamine metabolic process
VA208B3_28240	COG0471	metal ion transport
VA208B3_28270	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VA208B3_28280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VA208B3_28290	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VA208B3_28300	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VA208B3_28310	COG1045	serine acetyltransferase
VA208B3_28320	COG4942	peptidase
VA208B3_28360	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VA208B3_28370	COG1053	succinate dehydrogenase
VA208B3_28380	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VA208B3_28390	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VA208B3_28400	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VA208B3_28420	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VA208B3_28430	COG1509	lysine 2,3-aminomutase activity
VA208B3_28440	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VA208B3_28470	COG0459	protein refolding
VA208B3_28490	COG0534	Mate efflux family protein
VA208B3_28500	COG0205	6-phosphofructokinase activity
VA208B3_28520	COG3678	ATP-independent chaperone mediated protein folding
VA208B3_28530	COG0745	RESPONSE REGULATOR receiver
VA208B3_28540	COG2205	protein histidine kinase activity
VA208B3_28560	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VA208B3_28570	COG3030	protein affecting phage T7 exclusion by the F plasmid
VA208B3_28580	COG1027	Aspartate ammonia-lyase
VA208B3_28590	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VA208B3_28600	COG4232	protein-disulfide reductase activity
VA208B3_28620	COG3263	regulation of cellular component size
VA208B3_28640	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VA208B3_28680	COG0784	Response regulator, receiver
VA208B3_28680	COG2205	protein histidine kinase activity
VA208B3_28680	COG2198	Histidine kinase
VA208B3_28690	COG2814	Major facilitator Superfamily
VA208B3_28720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VA208B3_28730	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VA208B3_28740	COG0511	ligase activity, forming carbon-carbon bonds
VA208B3_28750	COG0439	Biotin carboxylase
VA208B3_28760	COG2264	protein methyltransferase activity
VA208B3_28770	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VA208B3_28780	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VA208B3_28790	COG2814	Major facilitator Superfamily
VA208B3_28800	COG0488	(ABC) transporter
VA208B3_28810	COG3706	GGDEF domain
VA208B3_28820	COG1982	Orn Lys Arg decarboxylase major
VA208B3_28830	COG0531	amino acid
VA208B3_28840	COG3710	Transcriptional regulator
VA208B3_28860	COG0789	Transcriptional regulator
VA208B3_28870	COG0138	bifunctional purine biosynthesis protein purh
VA208B3_28880	COG0151	Belongs to the GarS family
VA208B3_28910	COG1253	flavin adenine dinucleotide binding
VA208B3_28930	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VA208B3_28940	COG1573	uracil-dna glycosylase
VA208B3_28950	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VA208B3_28980	COG2816	NAD+ diphosphatase activity
VA208B3_28990	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VA208B3_29000	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VA208B3_29010	COG0085	RNA polymerase activity
VA208B3_29020	COG0222	ribosome binding
VA208B3_29030	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VA208B3_29040	COG0081	regulation of translation
VA208B3_29050	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VA208B3_29060	COG0250	Participates in transcription elongation, termination and antitermination
VA208B3_29070	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VA208B3_29080	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VA208B3_29110	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VA208B3_29130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VA208B3_29150	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VA208B3_29170	COG4206	TonB-dependent receptor
VA208B3_29180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VA208B3_29210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VA208B3_29220	COG0534	Mate efflux family protein
VA208B3_29230	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
VA208B3_29240	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VA208B3_29250	COG2937	Belongs to the GPAT DAPAT family
VA208B3_29260	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VA208B3_29270	COG3161	chorismate lyase activity
VA208B3_29280	COG1580	Controls the rotational direction of flagella during chemotaxis
VA208B3_29290	COG0705	Rhomboid family
VA208B3_29300	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VA208B3_29320	COG2177	Part of the ABC transporter FtsEX involved in
VA208B3_29330	COG2884	Cell division ATP-binding protein ftsE
VA208B3_29340	COG0552	protein localization to endoplasmic reticulum
VA208B3_29350	COG0742	ribosomal rna small subunit methyltransferase
VA208B3_29370	COG2095	MarC family integral membrane protein
VA208B3_29480	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VA208B3_29490	COG0640	Transcriptional regulator
VA208B3_29500	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VA208B3_29510	COG1280	lysine exporter protein (LysE YggA)
VA208B3_29520	COG2267	carboxylic ester hydrolase activity
VA208B3_29530	COG0561	phosphatase activity
VA208B3_29560	COG3148	PFAM DTW domain containing protein
VA208B3_29570	COG2200	EAL domain
VA208B3_29570	COG3287	FIST C domain
VA208B3_29570	COG2199	diguanylate cyclase activity
VA208B3_29580	COG1011	Hydrolase
VA208B3_29590	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VA208B3_29610	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VA208B3_29620	COG0019	diaminopimelate decarboxylase activity
VA208B3_29630	COG1965	Belongs to the frataxin family
VA208B3_29640	COG3072	Adenylate cyclase
VA208B3_29650	COG0181	hydroxymethylbilane synthase activity
VA208B3_29660	COG1587	Uroporphyrinogen-III synthase
VA208B3_29670	COG2959	enzyme of heme biosynthesis
VA208B3_29680	COG3071	HemY protein
VA208B3_29700	COG0633	Ferredoxin
VA208B3_29710	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VA208B3_29740	COG3118	belongs to the thioredoxin family
VA208B3_29750	COG0513	Belongs to the DEAD box helicase family
VA208B3_29760	COG0248	Ppx GppA phosphatase
VA208B3_29770	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VA208B3_29790	COG0514	ATP-dependent DNA helicase (RecQ)
VA208B3_29800	COG2962	Rard protein
VA208B3_29820	COG1280	lysine exporter protein (LysE YggA)
VA208B3_29830	COG0405	Gamma-glutamyltransferase
VA208B3_29840	COG0210	DNA helicase
VA208B3_29860	COG3220	belongs to the UPF0276 family
VA208B3_29920	COG0006	proline dipeptidase activity
VA208B3_29920	COG0006	proline dipeptidase activity
VA208B3_29940	COG2022	thiamine diphosphate biosynthetic process
VA208B3_29950	COG2104	thiamine diphosphate biosynthetic process
VA208B3_29960	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VA208B3_29970	COG0352	thiamine-phosphate diphosphorylase activity
VA208B3_29980	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VA208B3_29990	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VA208B3_30000	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VA208B3_30020	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VA208B3_30030	COG0408	coproporphyrinogen oxidase activity
VA208B3_30040	COG0009	L-threonylcarbamoyladenylate synthase
VA208B3_30050	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VA208B3_30060	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VA208B3_30070	COG0551	DNA topoisomerase type I activity
VA208B3_30080	COG2922	Belongs to the Smg family
VA208B3_30090	COG0758	DNA mediated transformation
VA208B3_30110	COG0242	peptide deformylase activity
VA208B3_30120	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VA208B3_30130	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VA208B3_30130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VA208B3_30140	COG0569	domain protein
VA208B3_30150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VA208B3_30170	COG1272	protein, Hemolysin III
VA208B3_30180	COG4326	sporulation control protein
VA208B3_30200	COG3084	Protein conserved in bacteria
VA208B3_30220	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VA208B3_30230	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VA208B3_30240	COG0204	Acyl-transferase
VA208B3_30260	COG0606	chelatase, subunit chli
VA208B3_30280	COG3978	acetolactate synthase activity
VA208B3_30290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VA208B3_30300	COG0129	dihydroxy-acid dehydratase activity
VA208B3_30320	COG0583	DNA-binding transcription factor activity
VA208B3_30330	COG2814	Major facilitator Superfamily
VA208B3_30340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VA208B3_30350	COG0765	amino acid transport
VA208B3_30360	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VA208B3_30370	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VA208B3_30380	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VA208B3_30390	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VA208B3_30400	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VA208B3_30410	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VA208B3_30440	COG0356	it plays a direct role in the translocation of protons across the membrane
VA208B3_30450	COG3312	ion transport
VA208B3_30460	COG1475	DNA binding
VA208B3_30470	COG1192	Involved in chromosome partitioning
VA208B3_30480	COG0357	Ribosomal RNA small subunit methyltransferase G
VA208B3_30490	COG0445	tRNA wobble uridine modification
VA208B3_30500	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VA208B3_30510	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VA208B3_30520	COG0706	membrane insertase activity
VA208B3_30530	COG0594	ribonuclease P activity
VA208B3_30550	COG1126	abc transporter atp-binding protein
VA208B3_30600	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VA208B3_30610	COG0581	inorganic phosphate transmembrane transporter activity
VA208B3_30620	COG0573	inorganic phosphate transmembrane transporter activity
VA208B3_30690	COG1770	oligopeptidase
VA208B3_30700	COG0513	Belongs to the DEAD box helicase family
VA208B3_30720	COG1376	ErfK ybiS ycfS ynhG family protein
VA208B3_30720	COG1388	LysM domain
VA208B3_30730	COG0415	Belongs to the DNA photolyase family
VA208B3_30740	COG0789	Transcriptional regulator
VA208B3_30750	COG3272	Protein of unknown function (DUF1722)
VA208B3_30760	COG0813	purine-nucleoside phosphorylase activity
VA208B3_30790	COG3706	GGDEF domain
VA208B3_30810	COG1566	PFAM secretion protein HlyD family protein
VA208B3_30820	COG4720	Psort location CytoplasmicMembrane, score
VA208B3_30830	COG1122	ATPase activity
VA208B3_30860	COG0348	domain, Protein
VA208B3_30870	COG0437	4 iron, 4 sulfur cluster binding
VA208B3_30880	COG1247	-acetyltransferase
VA208B3_30930	COG1067	ATP-dependent peptidase activity
VA208B3_30950	COG4172	Belongs to the ABC transporter superfamily
VA208B3_30960	COG1505	serine-type exopeptidase activity
VA208B3_30970	COG0583	DNA-binding transcription factor activity
VA208B3_30980	COG1620	l-lactate permease
VA208B3_30990	COG1304	FMN binding
VA208B3_31010	COG0668	transmembrane transport
VA208B3_31080	COG1063	alcohol dehydrogenase
VA208B3_31090	COG0156	8-amino-7-oxononanoate synthase activity
VA208B3_31110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VA208B3_31140	COG2205	protein histidine kinase activity
VA208B3_31160	COG0745	RESPONSE REGULATOR receiver
VA208B3_31210	COG0346	lactoylglutathione lyase activity
VA208B3_31240	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
VA208B3_31400	COG1987	bacterial-type flagellum assembly
VA208B3_31420	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
VA208B3_31450	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VA208B3_31470	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VA208B3_31480	COG1516	flagellar protein fliS
VA208B3_31510	COG1580	Controls the rotational direction of flagella during chemotaxis
VA208B3_31520	COG1191	sigma factor activity
VA208B3_31530	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VA208B3_31540	COG1360	Flagellar Motor Protein
VA208B3_31590	COG1882	Formate acetyltransferase
VA208B3_31600	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VA208B3_31610	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VA208B3_31630	COG0454	-acetyltransferase
VA208B3_31650	COG2814	Major facilitator Superfamily
VA208B3_31740	COG0628	permease
VA208B3_31750	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VA208B3_31770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VA208B3_31790	COG4628	conserved protein (DUF2132)
VA208B3_31800	COG0583	DNA-binding transcription factor activity
VA208B3_31850	COG1686	Belongs to the peptidase S11 family
VA208B3_31880	COG1054	Belongs to the UPF0176 family
VA208B3_31890	COG3397	chitin binding
VA208B3_31900	COG4667	esterase of the alpha-beta hydrolase superfamily
VA208B3_31910	COG2095	MarC family integral membrane protein
VA208B3_31950	COG3206	protein involved in exopolysaccharide biosynthesis
VA208B3_31950	COG0489	protein tyrosine kinase activity
VA208B3_31980	COG0583	DNA-binding transcription factor activity
VA208B3_32000	COG1301	dicarboxylic acid transport
VA208B3_32010	COG3339	Conserved Protein
VA208B3_32020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VA208B3_32030	COG0700	Nucleoside recognition
VA208B3_32040	COG3366	ferrous iron transmembrane transporter activity
VA208B3_32060	COG0366	Alpha amylase catalytic
VA208B3_32070	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VA208B3_32080	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VA208B3_32090	COG1640	4-alpha-glucanotransferase
VA208B3_32100	COG0058	SHG alpha-glucan phosphorylase activity
VA208B3_32120	COG2909	trisaccharide binding
VA208B3_32150	COG1999	signal sequence binding
VA208B3_32170	COG1263	PTS System
VA208B3_32170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VA208B3_32180	COG1162	GTPase activity
VA208B3_32190	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
VA208B3_32210	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
VA208B3_32230	COG0531	amino acid
VA208B3_32240	COG1982	Orn Lys Arg decarboxylase major
VA208B3_32280	COG2356	endonuclease I
VA208B3_32320	COG4580	involved in the transport of maltose and maltodextrins
VA208B3_32370	COG0739	heme binding
VA208B3_32390	COG0612	Peptidase, M16
VA208B3_32400	COG0840	transmembrane signaling receptor activity
VA208B3_32410	COG1120	ATPase activity
VA208B3_32420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VA208B3_32430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VA208B3_32440	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
VA208B3_32450	COG4772	TonB-dependent receptor
VA208B3_32500	COG4264	IucA IucC family
VA208B3_32510	COG0019	diaminopimelate decarboxylase activity
VA208B3_32520	COG1653	transport
VA208B3_32570	COG0826	peptidase U32
VA208B3_32580	COG1172	Belongs to the binding-protein-dependent transport system permease family
VA208B3_32590	COG1129	ABC transporter
VA208B3_32600	COG1879	ABC-type sugar transport system periplasmic component
VA208B3_32610	COG1069	ribulokinase activity
VA208B3_32630	COG2160	L-arabinose isomerase activity
VA208B3_32680	COG1764	response to oxidative stress
VA208B3_32690	COG1846	Transcriptional regulator
VA208B3_32710	COG3634	alkyl hydroperoxide reductase activity
VA208B3_32760	COG1595	DNA-templated transcription, initiation
VA208B3_32790	COG0583	DNA-binding transcription factor activity
VA208B3_32800	COG1486	melibiose metabolic process
VA208B3_32830	COG2258	MOSC domain
VA208B3_32840	COG0513	Belongs to the DEAD box helicase family
VA208B3_32880	COG2207	Transcriptional regulator
VA208B3_32900	COG1132	(ABC) transporter
VA208B3_32990	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VA208B3_33040	COG0259	pyridoxamine-phosphate oxidase activity
VA208B3_33140	COG4166	transmembrane transport
VA208B3_33170	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VA208B3_33180	COG1263	PTS System
VA208B3_33180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VA208B3_33190	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VA208B3_33200	COG3340	Belongs to the peptidase S51 family
VA208B3_33240	COG1444	tRNA N-acetyltransferase activity
VA208B3_33300	COG4608	Belongs to the ABC transporter superfamily
VA208B3_33310	COG0444	Belongs to the ABC transporter superfamily
VA208B3_33330	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VA208B3_33330	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
VA208B3_33370	COG0217	transcriptional regulatory protein
VA208B3_33380	COG0772	Belongs to the SEDS family
VA208B3_33400	COG1136	(ABC) transporter
VA208B3_33440	COG3275	phosphorelay sensor kinase activity
VA208B3_33450	COG3279	Response regulator of the LytR AlgR family
VA208B3_33470	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VA208B3_33510	COG0786	glutamate:sodium symporter activity
VA208B3_33530	COG1131	(ABC) transporter
VA208B3_33540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VA208B3_33550	COG0786	glutamate:sodium symporter activity
VA208B3_33570	COG0363	glucosamine-6-phosphate deaminase activity
VA208B3_33610	COG1741	Belongs to the pirin family
VA208B3_33620	COG1741	Belongs to the pirin family
VA208B3_33630	COG2259	Doxx family
VA208B3_33650	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
VA208B3_33660	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VA208B3_33680	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VA208B3_33760	COG3123	guanosine phosphorylase activity
VA208B3_33780	COG5001	Diguanylate cyclase
VA208B3_33790	COG0534	Mate efflux family protein
VA208B3_33800	COG0564	pseudouridine synthase activity
VA208B3_33830	COG0583	DNA-binding transcription factor activity
VA208B3_33840	COG0561	phosphatase activity
VA208B3_33860	COG2199	diguanylate cyclase activity
VA208B3_33890	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
VA208B3_33900	COG2162	N-hydroxyarylamine O-acetyltransferase activity
VA208B3_33910	COG0583	DNA-binding transcription factor activity
VA208B3_33940	COG1414	Transcriptional regulator
VA208B3_33950	COG1028	Short-chain dehydrogenase reductase Sdr
VA208B3_33970	COG1917	Cupin 2, conserved barrel domain protein
VA208B3_34000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VA208B3_34010	COG0800	Aldolase
VA208B3_34050	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VA208B3_34060	COG0823	Involved in the tonB-independent uptake of proteins
VA208B3_34070	COG2375	cellular response to nickel ion
VA208B3_34090	COG1522	sequence-specific DNA binding
VA208B3_34130	COG1357	PFAM Pentapeptide repeats (8 copies)
VA208B3_34140	COG3047	cAMP biosynthetic process
VA208B3_34200	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
VA208B3_34200	COG3408	Glycogen debranching enzyme
VA208B3_34210	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
VA208B3_34230	COG0583	DNA-binding transcription factor activity
VA208B3_34250	COG0583	DNA-binding transcription factor activity
VA208B3_34280	COG0546	phosphoglycolate phosphatase activity
VA208B3_34330	COG3835	regulator
VA208B3_34340	COG2610	gluconate transmembrane transporter activity
VA208B3_34350	COG1929	Belongs to the glycerate kinase type-1 family
VA208B3_34360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VA208B3_34400	COG0456	acetyltransferase
VA208B3_34430	COG1028	Short-chain dehydrogenase reductase Sdr
VA208B3_34450	COG3005	denitrification pathway
VA208B3_34460	COG0243	molybdopterin cofactor binding
VA208B3_34480	COG0352	thiamine-phosphate diphosphorylase activity
VA208B3_34490	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
VA208B3_34500	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
VA208B3_34510	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VA208B3_34520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VA208B3_34530	COG1116	anion transmembrane transporter activity
VA208B3_34540	COG0351	phosphomethylpyrimidine kinase
VA208B3_34550	COG0312	modulator of DNA gyrase
VA208B3_34560	COG0312	modulator of DNA gyrase
VA208B3_34570	COG1901	pseudouridine methyltransferase
VA208B3_34600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VA208B3_34620	COG0584	glycerophosphoryl diester phosphodiesterase
VA208B3_34630	COG0039	L-malate dehydrogenase activity
VA208B3_34640	COG0745	RESPONSE REGULATOR receiver
VA208B3_34680	COG0811	peptide transport
VA208B3_34690	COG0811	peptide transport
VA208B3_34700	COG0848	biopolymer transport protein
VA208B3_34780	COG0803	Belongs to the bacterial solute-binding protein 9 family
VA208B3_34790	COG1121	(ABC) transporter
VA208B3_34800	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VA208B3_34830	COG1770	oligopeptidase
VA208B3_34840	COG2814	Major facilitator Superfamily
VA208B3_34850	COG0010	Belongs to the arginase family
VA208B3_34860	COG1166	arginine decarboxylase activity
VA208B3_34880	COG4067	protein conserved in archaea
VA208B3_34880	COG0189	ligase activity
VA208B3_34890	COG0189	ligase activity
VA208B3_34910	COG0583	DNA-binding transcription factor activity
VA208B3_35000	COG2199	diguanylate cyclase activity
VA208B3_35040	COG0579	oxidoreductase
VA208B3_35060	COG3033	Beta-eliminating lyase
VA208B3_35080	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VA208B3_35110	COG3706	GGDEF domain
VA208B3_35120	COG0840	transmembrane signaling receptor activity
VA208B3_35150	COG3706	GGDEF domain
VA208B3_35160	COG0415	Belongs to the DNA photolyase family
VA208B3_35170	COG0415	Belongs to the DNA photolyase family
VA208B3_35180	COG3046	protein related to deoxyribodipyrimidine photolyase
VA208B3_35200	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VA208B3_35200	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VA208B3_35210	COG1765	OsmC-like protein
VA208B3_35230	COG1765	OsmC-like protein
VA208B3_35240	COG0110	maltose O-acetyltransferase activity
VA208B3_35320	COG1011	Hydrolase
VA208B3_35350	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VA208B3_35360	COG3338	carbonate dehydratase activity
VA208B3_35370	COG2067	long-chain fatty acid transport protein
VA208B3_35380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VA208B3_35390	COG0577	efflux transmembrane transporter activity
VA208B3_35390	COG1136	(ABC) transporter
VA208B3_35410	COG3240	lipase activity
VA208B3_35470	COG1609	Transcriptional regulator
VA208B3_35480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VA208B3_35490	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VA208B3_35500	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VA208B3_35510	COG1840	ABC-type Fe3 transport system, periplasmic component
VA208B3_35530	COG3842	ATPase activity
VA208B3_35580	COG2990	Protein conserved in bacteria
VA208B3_35600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VA208B3_35610	COG2866	Carboxypeptidase
VA208B3_35630	COG0583	DNA-binding transcription factor activity
VA208B3_35670	COG3104	oligopeptide transport
VA208B3_35680	COG1760	l-serine dehydratase
VA208B3_35720	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VA208B3_35730	COG0741	lytic transglycosylase activity
VA208B3_35770	COG1815	bacterial-type flagellum-dependent cell motility
VA208B3_35780	COG1558	bacterial-type flagellum-dependent cell motility
VA208B3_35790	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
VA208B3_35800	COG1749	Flagellar hook protein flgE
VA208B3_35810	COG4787	bacterial-type flagellum-dependent cell motility
VA208B3_35820	COG4786	Flagellar basal body rod
VA208B3_35830	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VA208B3_35840	COG1706	bacterial-type flagellum-dependent cell motility
VA208B3_35860	COG4786	Flagellar basal body rod
VA208B3_35860	COG1256	bacterial-type flagellum assembly
VA208B3_35870	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VA208B3_35910	COG1304	FMN binding
VA208B3_35960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VA208B3_35970	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VA208B3_35980	COG0459	protein refolding
VA208B3_36010	COG1280	lysine exporter protein (LysE YggA)
VA208B3_36050	COG1309	transcriptional regulator
VA208B3_36070	COG0737	Belongs to the 5'-nucleotidase family
VA208B3_36080	COG2070	2-Nitropropane dioxygenase
VA208B3_36090	COG3537	Alpha-1,2-mannosidase
VA208B3_36100	COG3537	Alpha-1,2-mannosidase
VA208B3_36120	COG3537	Alpha-1,2-mannosidase
VA208B3_36130	COG3537	Alpha-1,2-mannosidase
VA208B3_36140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VA208B3_36160	COG0583	DNA-binding transcription factor activity
VA208B3_36190	COG0346	lactoylglutathione lyase activity
VA208B3_36200	COG1349	DNA-binding transcription factor activity
VA208B3_36220	COG0753	catalase activity
VA208B3_36240	COG1335	isochorismatase
VA208B3_36260	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
VA208B3_36310	COG0583	DNA-binding transcription factor activity
VA208B3_36340	COG3713	MltA-interacting MipA family protein
VA208B3_36350	COG3015	lipoprotein NlpE involved in copper resistance
VA208B3_36360	COG1342	Belongs to the UPF0251 family
VA208B3_36420	COG4948	Mandelate Racemase Muconate Lactonizing
VA208B3_36440	COG0583	DNA-binding transcription factor activity
VA208B3_36510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VA208B3_36590	COG3842	ATPase activity
VA208B3_36650	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VA208B3_36690	COG3706	GGDEF domain
VA208B3_36740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VA208B3_36780	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VA208B3_36810	COG0574	Belongs to the PEP-utilizing enzyme family
VA208B3_36810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VA208B3_36820	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
VA208B3_36830	COG0252	asparaginase activity
VA208B3_36840	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VA208B3_36850	COG0583	DNA-binding transcription factor activity
VA208B3_36880	COG3122	Protein conserved in bacteria
VA208B3_36900	COG1028	Short-chain dehydrogenase reductase Sdr
VA208B3_36920	COG1063	alcohol dehydrogenase
VA208B3_36930	COG1902	pentaerythritol trinitrate reductase activity
VA208B3_36960	COG0583	DNA-binding transcription factor activity
VA208B3_36980	COG0513	Belongs to the DEAD box helicase family
VA208B3_37030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VA208B3_37040	COG2207	Transcriptional regulator
VA208B3_37040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VA208B3_37080	COG3746	phosphate-selective porin O and P
VA208B3_37110	COG1028	Short-chain dehydrogenase reductase Sdr
VA208B3_37180	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
VA208B3_37200	COG0625	glutathione transferase activity
VA208B3_37210	COG1686	Belongs to the peptidase S11 family
VA208B3_37270	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VA208B3_37300	COG1278	Cold shock
VA208B3_37310	COG1741	Belongs to the pirin family
VA208B3_37320	COG4667	esterase of the alpha-beta hydrolase superfamily
VA208B3_37370	COG2814	Major facilitator Superfamily
VA208B3_37380	COG0673	inositol 2-dehydrogenase activity
VA208B3_37390	COG2194	sulfuric ester hydrolase activity
VA208B3_37400	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VA208B3_37430	COG2205	protein histidine kinase activity
VA208B3_37440	COG0745	RESPONSE REGULATOR receiver
VA208B3_37450	COG4221	oxidoreductase activity
VA208B3_37480	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VA208B3_37520	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VA208B3_37540	COG2814	Major facilitator Superfamily
VA208B3_37560	COG1418	mRNA catabolic process
VA208B3_37580	COG0402	S-adenosylhomocysteine deaminase activity
VA208B3_37590	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
VA208B3_37600	COG2239	Acts as a magnesium transporter
VA208B3_37610	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VA208B3_37640	COG0531	amino acid
VA208B3_37650	COG1522	sequence-specific DNA binding
VA208B3_37660	COG0583	DNA-binding transcription factor activity
VA208B3_37710	COG0784	Response regulator, receiver
VA208B3_37710	COG2205	protein histidine kinase activity
VA208B3_37710	COG5002	protein histidine kinase activity
VA208B3_37720	COG0673	inositol 2-dehydrogenase activity
VA208B3_37730	COG0534	Mate efflux family protein
VA208B3_37740	COG2926	Belongs to the UPF0265 family
VA208B3_37760	COG3132	Protein of unknown function, DUF480
VA208B3_37770	COG2827	Endonuclease containing a URI domain
VA208B3_37780	COG1879	ABC-type sugar transport system periplasmic component
VA208B3_37790	COG2205	protein histidine kinase activity
VA208B3_37790	COG0784	Response regulator, receiver
VA208B3_37810	COG1566	PFAM secretion protein HlyD family protein
VA208B3_37850	COG1522	sequence-specific DNA binding
VA208B3_37910	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VA208B3_37920	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VA208B3_37940	COG1280	lysine exporter protein (LysE YggA)
VA208B3_37960	COG0183	Belongs to the thiolase family
VA208B3_38000	COG3005	denitrification pathway
VA208B3_38020	COG0243	molybdopterin cofactor binding
VA208B3_38040	COG3850	Histidine kinase
VA208B3_38050	COG2197	response regulator
VA208B3_38080	COG2195	Cleaves the N-terminal amino acid of tripeptides
VA208B3_38120	COG0840	transmembrane signaling receptor activity
VA208B3_38140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VA208B3_38160	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VA208B3_38170	COG2814	Major facilitator Superfamily
VA208B3_38180	COG0840	transmembrane signaling receptor activity
VA208B3_38190	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VA208B3_38200	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VA208B3_38240	COG2897	thiosulfate sulfurtransferase activity
VA208B3_38270	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VA208B3_38290	COG0302	gtp cyclohydrolase
VA208B3_38300	COG1914	H( )-stimulated, divalent metal cation uptake system
VA208B3_38320	COG0038	chloride channel
VA208B3_38350	COG4989	oxidoreductase activity
VA208B3_38380	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
VA208B3_38380	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
VA208B3_38390	COG0516	GMP reductase activity
VA208B3_38400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VA208B3_38530	COG3474	cytochrome
VA208B3_38550	COG0789	Transcriptional regulator
VA208B3_38560	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VA208B3_38570	COG0384	phenazine biosynthesis protein PhzF
VA208B3_38580	COG1294	oxidase, subunit
VA208B3_38590	COG1271	oxidase subunit
VA208B3_38600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VA208B3_38610	COG0110	maltose O-acetyltransferase activity
VA208B3_38620	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VA208B3_38620	COG3264	Mechanosensitive ion channel
VA208B3_38650	COG4999	Histidine kinase
VA208B3_38650	COG2205	protein histidine kinase activity
VA208B3_38650	COG3850	Histidine kinase
VA208B3_38650	COG3437	response regulator, receiver
VA208B3_38670	COG4770	biotin carboxylase activity
VA208B3_38690	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VA208B3_38700	COG1960	acyl-CoA dehydrogenase activity
VA208B3_38720	COG0183	Belongs to the thiolase family
VA208B3_38740	COG1960	acyl-CoA dehydrogenase activity
VA208B3_38750	COG1024	Enoyl-CoA hydratase
VA208B3_38780	COG1028	Short-chain dehydrogenase reductase Sdr
VA208B3_38790	COG3706	GGDEF domain
VA208B3_38800	COG1309	transcriptional regulator
VA208B3_38810	COG1012	belongs to the aldehyde dehydrogenase family
VA208B3_38840	COG4176	ABC-type proline glycine betaine transport system permease component
VA208B3_38850	COG0517	IMP dehydrogenase activity
VA208B3_38850	COG4175	Glycine betaine
VA208B3_38880	COG0330	HflC and HflK could
VA208B3_38900	COG3300	MHYT domain
VA208B3_38900	COG5001	Diguanylate cyclase
VA208B3_38920	COG2205	protein histidine kinase activity
VA208B3_38920	COG0784	Response regulator, receiver
VA208B3_39020	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VA208B3_39030	COG5001	Diguanylate cyclase
VA208B3_39040	COG1869	D-ribose catabolic process
VA208B3_39050	COG1129	ABC transporter
VA208B3_39060	COG1172	Belongs to the binding-protein-dependent transport system permease family
VA208B3_39070	COG1879	ABC-type sugar transport system periplasmic component
VA208B3_39080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VA208B3_39090	COG1609	Transcriptional regulator
VA208B3_39120	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VA208B3_39150	COG4607	ABC-type enterochelin transport system periplasmic component
VA208B3_39160	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VA208B3_39170	COG4605	iron ion homeostasis
VA208B3_39180	COG4604	ABC transporter, ATP-binding protein
VA208B3_39190	COG0789	Transcriptional regulator
VA208B3_39210	COG4771	TonB-dependent receptor
VA208B3_39210	COG1629	transport
VA208B3_39270	COG1289	transmembrane transporter activity
VA208B3_39280	COG0210	DNA helicase
VA208B3_39290	COG1803	Methylglyoxal synthase
VA208B3_39300	COG1879	ABC-type sugar transport system periplasmic component
VA208B3_39310	COG2205	protein histidine kinase activity
VA208B3_39310	COG2198	Histidine kinase
VA208B3_39310	COG0784	Response regulator, receiver
VA208B3_39340	COG0745	RESPONSE REGULATOR receiver
VA208B3_39350	COG3119	arylsulfatase activity
VA208B3_39360	COG3119	arylsulfatase activity
VA208B3_39390	COG3119	arylsulfatase activity
VA208B3_39400	COG0641	radical SAM
VA208B3_39410	COG0714	Associated with various cellular activities
VA208B3_39470	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VA208B3_39480	COG0583	DNA-binding transcription factor activity
VA208B3_39490	COG1597	lipid kinase activity
VA208B3_39500	COG3111	PFAM Bacterial OB fold (BOF) protein
VA208B3_39530	COG0641	radical SAM
VA208B3_39580	COG0501	Belongs to the peptidase M48B family
VA208B3_39590	COG1704	LemA family
VA208B3_39600	COG3069	C4-dicarboxylate transmembrane transporter activity
VA208B3_39660	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
VA208B3_39700	COG2207	Transcriptional regulator
VA208B3_39750	COG4964	Belongs to the GSP D family
VA208B3_39870	COG0583	DNA-binding transcription factor activity
VA208B3_39880	COG0583	DNA-binding transcription factor activity
VA208B3_39910	COG3300	MHYT domain
VA208B3_39910	COG5001	Diguanylate cyclase
VA208B3_39920	COG2197	response regulator
VA208B3_39930	COG3706	GGDEF domain
VA208B3_39950	COG2197	response regulator
VA208B3_39990	COG0784	Response regulator, receiver
VA208B3_39990	COG0835	chemotaxis
VA208B3_40040	COG0671	phosphoesterase, PA-phosphatase related
VA208B3_40070	COG2076	Multidrug Resistance protein
VA208B3_40130	COG0471	metal ion transport
VA208B3_40140	COG3290	protein histidine kinase activity
VA208B3_40150	COG4565	transcriptional regulatory protein
VA208B3_40180	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
VA208B3_40190	COG5642	Protein of unknown function (DUF2384)
VA208B3_40230	COG1902	pentaerythritol trinitrate reductase activity
VA208B3_40240	COG0346	lactoylglutathione lyase activity
VA208B3_40280	COG2239	Acts as a magnesium transporter
VA208B3_40320	COG0242	peptide deformylase activity
VA208B3_40400	COG2176	DNA-directed DNA polymerase activity
VA208B3_40410	COG0583	DNA-binding transcription factor activity
VA208B3_40420	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VA208B3_40430	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
VA208B3_40470	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VA208B3_40470	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VA208B3_40480	COG0509	glycine decarboxylation via glycine cleavage system
VA208B3_40490	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VA208B3_40570	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VA208B3_40570	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VA208B3_40570	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
VA208B3_40580	COG1105	Belongs to the carbohydrate kinase PfkB family
VA208B3_40590	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VA208B3_40590	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VA208B3_40600	COG1609	Transcriptional regulator
VA208B3_40630	COG2199	diguanylate cyclase activity
VA208B3_40630	COG2203	Gaf domain
VA208B3_40630	COG2200	EAL domain
VA208B3_40640	COG0765	amino acid transport
VA208B3_40650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VA208B3_40660	COG0765	amino acid transport
VA208B3_40670	COG1126	abc transporter atp-binding protein
VA208B3_40680	COG0469	pyruvate kinase activity
VA208B3_40690	COG2271	Major facilitator Superfamily
VA208B3_40740	COG1979	alcohol dehydrogenase
VA208B3_40750	COG2207	Transcriptional regulator
VA208B3_40770	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VA208B3_40780	COG2759	Belongs to the formate--tetrahydrofolate ligase family
VA208B3_40790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VA208B3_40820	COG3437	response regulator, receiver
VA208B3_40820	COG0784	Response regulator, receiver
VA208B3_40830	COG0546	phosphoglycolate phosphatase activity
VA208B3_40840	COG0840	transmembrane signaling receptor activity
VA208B3_40860	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
VA208B3_40870	COG0513	Belongs to the DEAD box helicase family
VA208B3_40880	COG4943	cyclic-guanylate-specific phosphodiesterase activity
VA208B3_40910	COG3038	cytochrome b561
VA208B3_40920	COG2353	YceI-like domain
VA208B3_40930	COG2116	formate transmembrane transporter activity
VA208B3_40940	COG0583	DNA-binding transcription factor activity
VA208B3_40960	COG3593	DNA synthesis involved in DNA repair
VA208B3_40970	COG0737	Belongs to the 5'-nucleotidase family
VA208B3_40980	COG0861	Integral membrane protein TerC family
VA208B3_41010	COG2267	carboxylic ester hydrolase activity
VA208B3_41020	COG2067	long-chain fatty acid transport protein
VA208B3_41050	COG2050	protein possibly involved in aromatic compounds catabolism
VA208B3_41070	COG4533	DNA binding
VA208B3_41130	COG0484	heat shock protein binding
VA208B3_41150	COG5001	Diguanylate cyclase
VA208B3_41150	COG3300	MHYT domain
VA208B3_41160	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VA208B3_41180	COG4181	ATPase activity
VA208B3_41190	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
VA208B3_41210	COG1984	allophanate hydrolase subunit 2
VA208B3_41220	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
VA208B3_41230	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VA208B3_41240	COG5002	protein histidine kinase activity
VA208B3_41240	COG5001	Diguanylate cyclase
VA208B3_41240	COG3447	MASE1 domain protein
VA208B3_41250	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VA208B3_41260	COG1629	transport
VA208B3_41260	COG4771	TonB-dependent receptor
VA208B3_41270	COG0583	DNA-binding transcription factor activity
VA208B3_41280	COG0045	succinate-CoA ligase (ADP-forming) activity
VA208B3_41280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VA208B3_41280	COG1042	CoA-binding domain protein
VA208B3_41300	COG1181	Belongs to the D-alanine--D-alanine ligase family
VA208B3_41320	COG0023	Translation Initiation Factor
VA208B3_41530	COG4128	Pfam Zonular occludens toxin
VA208B3_41640	COG0583	DNA-binding transcription factor activity
VA208B3_41660	COG0589	response to stress
VA208B3_41670	COG3140	Belongs to the UPF0181 family
VA208B3_41720	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VA208B3_41730	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VA208B3_41780	COG5001	Diguanylate cyclase
VA208B3_41780	COG4251	negative regulation of phosphorylation
VA208B3_41780	COG3706	GGDEF domain
VA208B3_41780	COG2203	Gaf domain
VA208B3_41800	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
VA208B3_41810	COG4149	molybdate abc transporter
VA208B3_41820	COG0725	ABC transporter, periplasmic molybdate-binding protein
VA208B3_41830	COG1492	cobalamin metabolic process
VA208B3_41840	COG3111	PFAM Bacterial OB fold (BOF) protein
VA208B3_41860	COG4067	protein conserved in archaea
VA208B3_41860	COG0189	ligase activity
VA208B3_41890	COG0534	Mate efflux family protein
VA208B3_41900	COG0602	queuosine metabolic process
VA208B3_41910	COG1328	CTP reductase activity
VA208B3_41940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VA208B3_42000	COG0243	molybdopterin cofactor binding
VA208B3_42010	COG0583	DNA-binding transcription factor activity
VA208B3_42020	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VA208B3_42040	COG2197	response regulator
VA208B3_42050	COG3851	Histidine kinase
VA208B3_42060	COG2271	Major facilitator Superfamily
VA208B3_42110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VA208B3_42120	COG3118	belongs to the thioredoxin family
VA208B3_42140	COG0745	RESPONSE REGULATOR receiver
VA208B3_42140	COG2205	protein histidine kinase activity
VA208B3_42140	COG3292	Two component regulator propeller
VA208B3_42150	COG0534	Mate efflux family protein
VA208B3_42210	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VA208B3_42250	COG2116	formate transmembrane transporter activity
VA208B3_42270	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VA208B3_42280	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VA208B3_42340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VA208B3_42340	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VA208B3_42400	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VA208B3_42430	COG0277	FAD linked oxidase domain protein
VA208B3_42440	COG0583	DNA-binding transcription factor activity
VA208B3_42450	COG2425	protein containing a von Willebrand factor type A (vWA) domain
VA208B3_42480	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
VA208B3_42500	COG1288	antiporter activity
VA208B3_42520	COG2814	Major facilitator Superfamily
VA208B3_42540	COG3040	lipid binding
VA208B3_42580	COG0419	ATPase involved in DNA repair
VA208B3_42590	COG0420	3'-5' exonuclease activity
VA208B3_42730	COG0631	protein serine/threonine phosphatase activity
VA208B3_42800	COG2815	serine threonine protein kinase
VA208B3_42800	COG0515	serine threonine protein kinase
VA208B3_42900	COG2146	nitrite reductase [NAD(P)H] activity
VA208B3_42900	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VA208B3_42910	COG1116	anion transmembrane transporter activity
VA208B3_42920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VA208B3_42930	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VA208B3_42940	COG3707	response regulator
VA208B3_42970	COG1648	precorrin-2 dehydrogenase activity
VA208B3_42970	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VA208B3_42980	COG0243	molybdopterin cofactor binding
VA208B3_43000	COG0814	amino acid
VA208B3_43050	COG1785	Belongs to the alkaline phosphatase family
VA208B3_43080	COG0745	RESPONSE REGULATOR receiver
VA208B3_43130	COG2847	Copper chaperone PCu(A)C
VA208B3_43140	COG0443	Heat shock 70 kDa protein
VA208B3_43210	COG0625	glutathione transferase activity
VA208B3_43240	COG4160	amino acid transport
VA208B3_43250	COG4215	(ABC) transporter
VA208B3_43260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VA208B3_43270	COG1126	abc transporter atp-binding protein
VA208B3_43330	COG1902	pentaerythritol trinitrate reductase activity
VA208B3_43340	COG0109	protoheme IX farnesyltransferase activity
VA208B3_43350	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
VA208B3_43360	COG1845	cytochrome c oxidase, subunit III
VA208B3_43370	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VA208B3_43380	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VA208B3_43390	COG1028	Short-chain dehydrogenase reductase Sdr
VA208B3_43410	COG1024	Enoyl-CoA hydratase
VA208B3_43420	COG1024	Enoyl-CoA hydratase
VA208B3_43450	COG0183	Belongs to the thiolase family
VA208B3_43470	COG1960	acyl-CoA dehydrogenase activity
VA208B3_43480	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VA208B3_43490	COG1024	Enoyl-CoA hydratase
VA208B3_43510	COG5413	integral membrane protein
VA208B3_43540	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VA208B3_43550	COG5001	Diguanylate cyclase
VA208B3_43560	COG0513	Belongs to the DEAD box helicase family
VA208B3_43570	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
VA208B3_43600	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VA208B3_43630	COG0641	radical SAM
VA208B3_43670	COG0840	transmembrane signaling receptor activity
VA208B3_43680	COG1119	ATPase activity
VA208B3_43690	COG2200	EAL domain
VA208B3_43730	COG0513	Belongs to the DEAD box helicase family
VA208B3_43740	COG0523	cobalamin synthesis protein
VA208B3_43760	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
VA208B3_43780	COG0133	tryptophan synthase activity
VA208B3_43790	COG4628	conserved protein (DUF2132)
VA208B3_43800	COG0513	Belongs to the DEAD box helicase family
VA208B3_43810	COG3530	Putative quorum-sensing-regulated virulence factor
VA208B3_43850	COG2154	pterin-4-alpha-carbinolamine dehydratase
VA208B3_43860	COG3186	Phenylalanine-4-hydroxylase
VA208B3_43870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VA208B3_43880	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VA208B3_43960	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
VA208B3_43970	COG1454	alcohol dehydrogenase
VA208B3_43980	COG2133	pyrroloquinoline quinone binding
VA208B3_44000	COG0783	Belongs to the Dps family
VA208B3_44010	COG0840	transmembrane signaling receptor activity
VA208B3_44040	COG0577	efflux transmembrane transporter activity
VA208B3_44040	COG1136	(ABC) transporter
VA208B3_44080	COG2199	diguanylate cyclase activity
VA208B3_44100	COG3036	rescue of stalled ribosome
VA208B3_44120	COG1278	Cold shock
VA208B3_44180	COG0545	Peptidyl-prolyl cis-trans isomerase
VA208B3_44190	COG0109	protoheme IX farnesyltransferase activity
VA208B3_44200	COG1612	heme a metabolic process
VA208B3_44250	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
VA208B3_44290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VA208B3_44310	COG1280	lysine exporter protein (LysE YggA)
VA208B3_44320	COG2207	Transcriptional regulator
VA208B3_44370	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VA208B3_44380	COG0697	spore germination
VA208B3_44420	COG2814	Major facilitator Superfamily
VA208B3_44430	COG0583	DNA-binding transcription factor activity
VA208B3_44440	COG5001	Diguanylate cyclase
VA208B3_44450	COG0739	heme binding
VA208B3_44500	COG3314	Sporulation integral membrane protein YlbJ
VA208B3_44530	COG0814	amino acid
VA208B3_44560	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
VA208B3_44570	COG1072	(Pantothenic acid kinase))
VA208B3_44590	COG1063	alcohol dehydrogenase
VA208B3_44600	COG2213	PTS system mannitol-specific
VA208B3_44610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VA208B3_44640	COG0798	PFAM Bile acid sodium symporter
VA208B3_44660	COG1881	PFAM PEBP family protein
VA208B3_44680	COG2706	6-phosphogluconolactonase activity
VA208B3_44710	COG1131	(ABC) transporter
VA208B3_44720	COG0842	Transport permease protein
VA208B3_44750	COG3383	formate dehydrogenase (NAD+) activity
VA208B3_44780	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VA208B3_44840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VA208B3_44860	COG2067	long-chain fatty acid transport protein
VA208B3_44880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VA208B3_44900	COG1505	serine-type exopeptidase activity
VA208B3_44910	COG0488	(ABC) transporter
VA208B3_44920	COG0589	response to stress
VA208B3_44930	COG2249	NAD(P)H dehydrogenase (quinone) activity
VA208B3_44970	COG0366	Alpha amylase catalytic
VA208B3_44990	COG4934	collagen metabolic process
VA208B3_45020	COG0583	DNA-binding transcription factor activity
VA208B3_45030	COG0783	Belongs to the Dps family
VA208B3_45040	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
VA208B3_45090	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
VA208B3_45090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VA208B3_45110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VA208B3_45120	COG0784	Response regulator, receiver
VA208B3_45120	COG0835	chemotaxis
VA208B3_45140	COG0748	coenzyme F420 binding
VA208B3_45150	COG3721	Heme iron utilization protein
VA208B3_45170	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VA208B3_45180	COG0811	peptide transport
VA208B3_45190	COG0848	biopolymer transport protein
VA208B3_45210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VA208B3_45220	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VA208B3_45300	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VA208B3_45310	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VA208B3_45320	COG0633	Ferredoxin
VA208B3_45320	COG3217	Mosc domain protein beta barrel domain protein
VA208B3_45320	COG3217	Mosc domain protein beta barrel domain protein
VA208B3_45320	COG0633	Ferredoxin
VA208B3_45330	COG0401	homolog of Blt101
VA208B3_45340	COG0418	dihydroorotase activity
VA208B3_45350	COG2354	Protein conserved in bacteria
VA208B3_45410	COG3833	ABC-type maltose transport systems, permease component
VA208B3_45420	COG1175	transmembrane transport
VA208B3_45440	COG3842	ATPase activity
VA208B3_45500	COG0438	transferase activity, transferring glycosyl groups
VA208B3_45560	COG3097	Belongs to the UPF0267 family
VA208B3_45570	COG1309	transcriptional regulator
VA208B3_45580	COG2130	NADP-dependent
VA208B3_45600	COG0753	catalase activity
VA208B3_45610	COG2084	Dehydrogenase
VA208B3_45620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VA208B3_45630	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VA208B3_45650	COG2207	Transcriptional regulator
VA208B3_45660	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VA208B3_45660	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VA208B3_45660	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VA208B3_45690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VA208B3_45700	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
VA208B3_45710	COG5001	Diguanylate cyclase
VA208B3_45710	COG3300	MHYT domain
VA208B3_45720	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VA208B3_45730	COG0569	domain protein
VA208B3_45750	COG2205	protein histidine kinase activity
VA208B3_45750	COG2205	protein histidine kinase activity
VA208B3_45760	COG1132	(ABC) transporter
VA208B3_45770	COG4774	siderophore transport
VA208B3_45780	COG1120	ATPase activity
VA208B3_45790	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
VA208B3_45890	COG2197	response regulator
VA208B3_45910	COG0840	transmembrane signaling receptor activity
VA208B3_45920	COG0714	Associated with various cellular activities
VA208B3_46050	COG2203	Gaf domain
VA208B3_46050	COG3706	GGDEF domain
VA208B3_46050	COG4251	negative regulation of phosphorylation
VA208B3_46050	COG5001	Diguanylate cyclase
VA208B3_46090	COG2801	Transposase and inactivated derivatives
VA208B3_46530	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VA208B3_46880	COG1199	ATP-dependent helicase activity
VA208B3_46990	COG0210	DNA helicase
VA208B3_47100	COG4206	TonB-dependent receptor
VA208B3_47220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VA208B3_47370	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VA208B3_47400	COG0681	Belongs to the peptidase S26 family
VA208B3_47560	COG1475	DNA binding
VA208B3_47850	COG3177	Filamentation induced by cAMP protein fic
VA208B3_48360	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VA208B3_48370	COG0653	protein targeting
VA208B3_48390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VA208B3_48440	COG0776	regulation of translation
VA208B3_48520	COG3385	transposase activity
VA208B3_48620	COG2353	YceI-like domain
VA208B3_48630	COG3038	cytochrome b561
VA208B3_48660	COG4644	lycopene metabolic process
VA208B3_48670	COG4644	lycopene metabolic process
VA208B3_48690	COG0840	transmembrane signaling receptor activity
VA208B3_48710	COG0697	spore germination
VA208B3_48720	COG0583	DNA-binding transcription factor activity
VA208B3_48760	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
VA208B3_48770	COG0110	maltose O-acetyltransferase activity
VA208B3_48780	COG0561	phosphatase activity
VA208B3_48790	COG1349	DNA-binding transcription factor activity
VA208B3_48820	COG3300	MHYT domain
VA208B3_48820	COG5001	Diguanylate cyclase
VA208B3_48830	COG5001	Diguanylate cyclase
VA208B3_48830	COG4251	negative regulation of phosphorylation
VA208B3_48830	COG3706	GGDEF domain
VA208B3_48830	COG2203	Gaf domain
VA208B3_48850	COG2205	protein histidine kinase activity
VA208B3_48870	COG2801	Transposase and inactivated derivatives
VA208B3_49050	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VA208B3_49070	COG0754	glutathionylspermidine amidase activity
VA208B3_49150	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VA208B3_49320	COG4943	cyclic-guanylate-specific phosphodiesterase activity
VA208B3_49370	COG2801	Transposase and inactivated derivatives
VA208B3_49430	COG2916	Histone family protein nucleoid-structuring protein H-NS