locus-tag	class	description
VagVIO5_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VagVIO5_00020	COG0592	DNA-directed DNA polymerase activity
VagVIO5_00040	COG0187	DNA topoisomerase II activity
VagVIO5_00070	COG0071	Belongs to the small heat shock protein (HSP20) family
VagVIO5_00080	COG3977	Valine--pyruvate aminotransferase
VagVIO5_00090	COG0366	Alpha amylase catalytic
VagVIO5_00100	COG0751	glycine-tRNA ligase activity
VagVIO5_00120	COG2119	membrane
VagVIO5_00140	COG0425	Belongs to the sulfur carrier protein TusA family
VagVIO5_00170	COG0604	alcohol dehydrogenase
VagVIO5_00180	COG0183	Belongs to the thiolase family
VagVIO5_00200	COG1739	Uncharacterized protein family UPF0029
VagVIO5_00210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VagVIO5_00230	COG0583	DNA-binding transcription factor activity
VagVIO5_00240	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VagVIO5_00250	COG2960	long-chain fatty acid transporting porin activity
VagVIO5_00260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VagVIO5_00270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VagVIO5_00330	COG4166	transmembrane transport
VagVIO5_00350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VagVIO5_00420	COG1609	Transcriptional regulator
VagVIO5_00430	COG0583	DNA-binding transcription factor activity
VagVIO5_00460	COG0129	dihydroxy-acid dehydratase activity
VagVIO5_00470	COG3265	gluconokinase activity
VagVIO5_00480	COG2610	gluconate transmembrane transporter activity
VagVIO5_00490	COG0800	Aldolase
VagVIO5_00500	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
VagVIO5_00510	COG0583	DNA-binding transcription factor activity
VagVIO5_00520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VagVIO5_00530	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VagVIO5_00550	COG1522	sequence-specific DNA binding
VagVIO5_00560	COG5002	protein histidine kinase activity
VagVIO5_00560	COG5001	Diguanylate cyclase
VagVIO5_00570	COG0742	ribosomal rna small subunit methyltransferase
VagVIO5_00600	COG0589	response to stress
VagVIO5_00610	COG1528	Iron-storage protein
VagVIO5_00630	COG2081	HI0933 family
VagVIO5_00640	COG2204	response regulator
VagVIO5_00690	COG1597	lipid kinase activity
VagVIO5_00750	COG0628	permease
VagVIO5_00780	COG1322	Protein conserved in bacteria
VagVIO5_00790	COG2226	methyltransferase
VagVIO5_00800	COG3165	ubiquinone biosynthetic process from chorismate
VagVIO5_00810	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VagVIO5_00830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VagVIO5_00840	COG0805	protein transport
VagVIO5_00850	COG0084	hydrolase, TatD family'
VagVIO5_00870	COG0456	acetyltransferase
VagVIO5_00880	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VagVIO5_00880	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VagVIO5_00890	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VagVIO5_00950	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VagVIO5_00970	COG2204	response regulator
VagVIO5_00980	COG3852	Histidine kinase
VagVIO5_01000	COG0174	glutamine synthetase
VagVIO5_01040	COG1295	ribonuclease BN
VagVIO5_01050	COG1490	D-aminoacyl-tRNA deacylase activity
VagVIO5_01060	COG0456	acetyltransferase
VagVIO5_01080	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VagVIO5_01090	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VagVIO5_01100	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VagVIO5_01110	COG3031	protein transport across the cell outer membrane
VagVIO5_01130	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VagVIO5_01140	COG1459	type II secretion system
VagVIO5_01150	COG2165	general secretion pathway protein
VagVIO5_01160	COG2165	general secretion pathway protein
VagVIO5_01170	COG2165	general secretion pathway protein
VagVIO5_01180	COG4795	General secretion pathway protein
VagVIO5_01190	COG3156	type II secretion system protein K
VagVIO5_01200	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VagVIO5_01210	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VagVIO5_01230	COG1218	3'(2'),5'-bisphosphate nucleotidase
VagVIO5_01240	COG0494	nUDIX hydrolase
VagVIO5_01250	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VagVIO5_01250	COG0316	Belongs to the HesB IscA family
VagVIO5_01260	COG1040	competence protein
VagVIO5_01270	COG0596	Alpha beta hydrolase
VagVIO5_01290	COG2183	response to ionizing radiation
VagVIO5_01310	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VagVIO5_01330	COG0745	RESPONSE REGULATOR receiver
VagVIO5_01340	COG2205	protein histidine kinase activity
VagVIO5_01350	COG2233	PERMEase
VagVIO5_01360	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VagVIO5_01370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VagVIO5_01380	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VagVIO5_01390	COG1758	RNA polymerase activity
VagVIO5_01400	COG0194	GDP metabolic process
VagVIO5_01430	COG0848	biopolymer transport protein
VagVIO5_01440	COG0811	peptide transport
VagVIO5_01480	COG4174	ABC transporter (Permease)
VagVIO5_01490	COG4239	(ABC) transporter, permease
VagVIO5_01500	COG0747	negative chemotaxis
VagVIO5_01510	COG0444	Belongs to the ABC transporter superfamily
VagVIO5_01520	COG4608	Belongs to the ABC transporter superfamily
VagVIO5_01540	COG1561	YicC-like family, N-terminal region
VagVIO5_01550	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VagVIO5_01570	COG1560	Kdo2-lipid A biosynthetic process
VagVIO5_01580	COG1309	transcriptional regulator
VagVIO5_01590	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VagVIO5_01610	COG2003	Belongs to the UPF0758 family
VagVIO5_01700	COG0463	Glycosyl transferase, family 2
VagVIO5_01710	COG0859	PFAM glycosyl transferase family 9
VagVIO5_01720	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VagVIO5_01730	COG3642	lipopolysaccharide core region biosynthetic process
VagVIO5_01770	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VagVIO5_01790	COG1086	Polysaccharide biosynthesis protein
VagVIO5_01800	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VagVIO5_01810	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VagVIO5_01820	COG2089	acid synthase
VagVIO5_01840	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
VagVIO5_01850	COG1083	cytidylyl-transferase
VagVIO5_01870	COG1519	Transferase
VagVIO5_01880	COG0859	PFAM glycosyl transferase family 9
VagVIO5_01890	COG1560	Kdo2-lipid A biosynthetic process
VagVIO5_01910	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VagVIO5_02070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VagVIO5_02080	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VagVIO5_02090	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VagVIO5_02140	COG1045	serine acetyltransferase
VagVIO5_02170	COG0438	transferase activity, transferring glycosyl groups
VagVIO5_02180	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VagVIO5_02200	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VagVIO5_02240	COG0149	triose-phosphate isomerase activity
VagVIO5_02290	COG1494	fructose-1,6-bisphosphatase
VagVIO5_02310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VagVIO5_02320	COG1575	Belongs to the MenA family. Type 1 subfamily
VagVIO5_02330	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VagVIO5_02340	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VagVIO5_02370	COG1609	Transcriptional regulator
VagVIO5_02380	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VagVIO5_02390	COG0254	rRNA binding
VagVIO5_02410	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VagVIO5_02420	COG0088	Forms part of the polypeptide exit tunnel
VagVIO5_02440	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VagVIO5_02450	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VagVIO5_02460	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VagVIO5_02470	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VagVIO5_02490	COG0255	Belongs to the universal ribosomal protein uL29 family
VagVIO5_02500	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VagVIO5_02520	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VagVIO5_02530	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VagVIO5_02540	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VagVIO5_02550	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VagVIO5_02560	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VagVIO5_02590	COG1841	ribosomal large subunit assembly
VagVIO5_02610	COG0201	protein transport
VagVIO5_02620	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VagVIO5_02630	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VagVIO5_02640	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VagVIO5_02660	COG0202	RNA polymerase activity
VagVIO5_02670	COG0203	ribosomal protein L17
VagVIO5_02690	COG0545	Peptidyl-prolyl cis-trans isomerase
VagVIO5_02710	COG2153	protein acetylation
VagVIO5_02720	COG0513	Belongs to the DEAD box helicase family
VagVIO5_02740	COG0737	Belongs to the 5'-nucleotidase family
VagVIO5_02750	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VagVIO5_02750	COG1648	precorrin-2 dehydrogenase activity
VagVIO5_02760	COG0175	sulfate reduction
VagVIO5_02770	COG2895	sulfate adenylyltransferase (ATP) activity
VagVIO5_02780	COG3273	potassium ion transport
VagVIO5_02780	COG0471	metal ion transport
VagVIO5_02790	COG0529	Catalyzes the synthesis of activated sulfate
VagVIO5_02840	COG4181	ATPase activity
VagVIO5_02870	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VagVIO5_02890	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VagVIO5_02900	COG0729	surface antigen
VagVIO5_02910	COG2911	Protein conserved in bacteria
VagVIO5_02920	COG2105	PFAM AIG2 family protein
VagVIO5_02940	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VagVIO5_02950	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VagVIO5_02960	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VagVIO5_02970	COG0163	prenyltransferase activity
VagVIO5_02980	COG4143	(ABC) transporter
VagVIO5_02990	COG1178	ABC-type Fe3 transport system permease component
VagVIO5_03000	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VagVIO5_03010	COG0583	DNA-binding transcription factor activity
VagVIO5_03020	COG1902	pentaerythritol trinitrate reductase activity
VagVIO5_03050	COG2358	TRAP transporter, solute receptor (TAXI family
VagVIO5_03090	COG0142	geranyltranstransferase activity
VagVIO5_03100	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VagVIO5_03120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VagVIO5_03130	COG2966	Psort location CytoplasmicMembrane, score
VagVIO5_03160	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VagVIO5_03170	COG2967	ApaG domain
VagVIO5_03180	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VagVIO5_03190	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VagVIO5_03200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VagVIO5_03210	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VagVIO5_03220	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VagVIO5_03260	COG0473	3-isopropylmalate dehydrogenase activity
VagVIO5_03270	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VagVIO5_03310	COG0583	DNA-binding transcription factor activity
VagVIO5_03320	COG1022	Amp-dependent synthetase and ligase
VagVIO5_03330	COG0028	Belongs to the TPP enzyme family
VagVIO5_03350	COG3706	GGDEF domain
VagVIO5_03370	COG0469	pyruvate kinase activity
VagVIO5_03380	COG1349	DNA-binding transcription factor activity
VagVIO5_03390	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VagVIO5_03420	COG5002	protein histidine kinase activity
VagVIO5_03440	COG2376	Dihydroxyacetone kinase
VagVIO5_03450	COG1461	Dihydroxyacetone kinase
VagVIO5_03480	COG3722	fumarate hydratase activity
VagVIO5_03490	COG0246	Mannitol dehydrogenase
VagVIO5_03500	COG2213	PTS system mannitol-specific
VagVIO5_03500	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VagVIO5_03560	COG1464	Belongs to the NlpA lipoprotein family
VagVIO5_03580	COG0358	DNA primase activity
VagVIO5_03590	COG1610	YqeY-like protein
VagVIO5_03600	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VagVIO5_03610	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VagVIO5_03620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
VagVIO5_03630	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VagVIO5_03640	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VagVIO5_03650	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VagVIO5_03660	COG1968	undecaprenyl-diphosphatase activity
VagVIO5_03670	COG0617	tRNA 3'-terminal CCA addition
VagVIO5_03680	COG3409	Peptidoglycan-binding domain 1 protein
VagVIO5_03680	COG3267	Type II secretory pathway component ExeA
VagVIO5_03700	COG0405	Gamma-glutamyltransferase
VagVIO5_03710	COG4991	sh3 domain protein
VagVIO5_03720	COG0306	phosphate transporter
VagVIO5_03730	COG1392	Phosphate transport regulator
VagVIO5_03740	COG3025	triphosphatase activity
VagVIO5_03770	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VagVIO5_03780	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VagVIO5_03780	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VagVIO5_03790	COG1538	Outer membrane efflux protein
VagVIO5_03800	COG0494	nUDIX hydrolase
VagVIO5_03810	COG3151	Protein conserved in bacteria
VagVIO5_03830	COG3150	esterase
VagVIO5_03850	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VagVIO5_03860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VagVIO5_03880	COG3105	Protein conserved in bacteria
VagVIO5_03890	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VagVIO5_03900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VagVIO5_03910	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VagVIO5_03920	COG0723	plastoquinol--plastocyanin reductase activity
VagVIO5_03930	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VagVIO5_03940	COG2857	Cytochrome c1
VagVIO5_03950	COG0625	glutathione transferase activity
VagVIO5_03960	COG2969	positive regulation of protein catabolic process
VagVIO5_03970	COG2823	Periplasmic or secreted lipoprotein
VagVIO5_03980	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VagVIO5_04010	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VagVIO5_04030	COG3116	cell division
VagVIO5_04040	COG0768	penicillin binding
VagVIO5_04050	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VagVIO5_04060	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VagVIO5_04070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VagVIO5_04080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VagVIO5_04090	COG0772	Belongs to the SEDS family
VagVIO5_04110	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VagVIO5_04120	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VagVIO5_04130	COG0849	cell division
VagVIO5_04140	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VagVIO5_04150	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VagVIO5_04170	COG0653	protein targeting
VagVIO5_04180	COG0494	nUDIX hydrolase
VagVIO5_04210	COG0505	Belongs to the CarA family
VagVIO5_04220	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VagVIO5_04250	COG0730	response to heat
VagVIO5_04260	COG0583	DNA-binding transcription factor activity
VagVIO5_04270	COG2860	membrane
VagVIO5_04320	COG0493	'glutamate synthase
VagVIO5_04330	COG0069	glutamate synthase activity
VagVIO5_04330	COG0070	glutamate synthase
VagVIO5_04330	COG0067	glutamate synthase
VagVIO5_04350	COG0069	glutamate synthase activity
VagVIO5_04350	COG0067	glutamate synthase
VagVIO5_04350	COG0070	glutamate synthase
VagVIO5_04360	COG1242	4 iron, 4 sulfur cluster binding
VagVIO5_04370	COG5001	Diguanylate cyclase
VagVIO5_04370	COG3706	GGDEF domain
VagVIO5_04370	COG4251	negative regulation of phosphorylation
VagVIO5_04370	COG2203	Gaf domain
VagVIO5_04380	COG5002	protein histidine kinase activity
VagVIO5_04380	COG2198	Histidine kinase
VagVIO5_04380	COG0784	Response regulator, receiver
VagVIO5_04400	COG0745	RESPONSE REGULATOR receiver
VagVIO5_04420	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VagVIO5_04450	COG0083	homoserine kinase activity
VagVIO5_04460	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VagVIO5_04480	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VagVIO5_04490	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VagVIO5_04500	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VagVIO5_04530	COG1115	amino acid carrier protein
VagVIO5_04540	COG3022	response to hydroperoxide
VagVIO5_04550	COG0513	Belongs to the DEAD box helicase family
VagVIO5_04560	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VagVIO5_04580	COG0716	FMN binding
VagVIO5_04590	COG4974	Belongs to the 'phage' integrase family
VagVIO5_04600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VagVIO5_04610	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VagVIO5_04620	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VagVIO5_04630	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VagVIO5_04640	COG2204	response regulator
VagVIO5_04670	COG0667	Aldo Keto reductase
VagVIO5_04720	COG0730	response to heat
VagVIO5_04740	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VagVIO5_04760	COG1283	sodium-dependent phosphate transmembrane transporter activity
VagVIO5_04770	COG0583	DNA-binding transcription factor activity
VagVIO5_04780	COG0640	Transcriptional regulator
VagVIO5_04790	COG0268	Binds directly to 16S ribosomal RNA
VagVIO5_04800	COG0728	peptidoglycan biosynthetic process
VagVIO5_04810	COG0196	riboflavin kinase activity
VagVIO5_04830	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VagVIO5_04840	COG1047	Peptidyl-prolyl cis-trans
VagVIO5_04850	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VagVIO5_04890	COG3279	Response regulator of the LytR AlgR family
VagVIO5_04900	COG3275	phosphorelay sensor kinase activity
VagVIO5_04910	COG1966	Carbon starvation protein
VagVIO5_04950	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VagVIO5_04960	COG1472	Belongs to the glycosyl hydrolase 3 family
VagVIO5_04970	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VagVIO5_04980	COG0287	Prephenate dehydrogenase
VagVIO5_04980	COG1605	Chorismate mutase
VagVIO5_04990	COG0739	heme binding
VagVIO5_04990	COG0741	lytic transglycosylase activity
VagVIO5_04990	COG1196	nuclear chromosome segregation
VagVIO5_05010	COG0488	(ABC) transporter
VagVIO5_05030	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VagVIO5_05040	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VagVIO5_05050	COG1605	Chorismate mutase
VagVIO5_05050	COG0077	Prephenate dehydratase
VagVIO5_05060	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VagVIO5_05070	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VagVIO5_05080	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VagVIO5_05090	COG0564	pseudouridine synthase activity
VagVIO5_05110	COG0542	response to heat
VagVIO5_05150	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VagVIO5_05170	COG2974	May be involved in recombination
VagVIO5_05180	COG0745	RESPONSE REGULATOR receiver
VagVIO5_05190	COG5002	protein histidine kinase activity
VagVIO5_05210	COG0248	Ppx GppA phosphatase
VagVIO5_05220	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VagVIO5_05230	COG0573	inorganic phosphate transmembrane transporter activity
VagVIO5_05240	COG0581	inorganic phosphate transmembrane transporter activity
VagVIO5_05250	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VagVIO5_05260	COG0704	Plays a role in the regulation of phosphate uptake
VagVIO5_05280	COG3142	Participates in the control of copper homeostasis
VagVIO5_05290	COG0450	alkyl hydroperoxide reductase
VagVIO5_05300	COG0583	DNA-binding transcription factor activity
VagVIO5_05310	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VagVIO5_05330	COG0517	IMP dehydrogenase activity
VagVIO5_05350	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VagVIO5_05370	COG1862	Preprotein translocase
VagVIO5_05380	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VagVIO5_05390	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VagVIO5_05400	COG0483	inositol monophosphate 1-phosphatase activity
VagVIO5_05410	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
VagVIO5_05430	COG1104	cysteine desulfurase activity
VagVIO5_05440	COG0822	iron-sulfur transferase activity
VagVIO5_05470	COG0443	Heat shock 70 kDa protein
VagVIO5_05480	COG0633	Ferredoxin
VagVIO5_05490	COG2975	iron-sulfur cluster assembly
VagVIO5_05510	COG0105	UTP biosynthetic process
VagVIO5_05540	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VagVIO5_05550	COG0124	histidyl-tRNA synthetase
VagVIO5_05560	COG2976	Protein conserved in bacteria
VagVIO5_05570	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VagVIO5_05580	COG1160	GTP binding
VagVIO5_05620	COG0516	GMP reductase activity
VagVIO5_05620	COG0517	IMP dehydrogenase activity
VagVIO5_05630	COG0519	Catalyzes the synthesis of GMP from XMP
VagVIO5_05630	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VagVIO5_05640	COG0582	viral genome integration into host DNA
VagVIO5_05800	COG1757	Na H antiporter
VagVIO5_05820	COG1584	GPR1 FUN34 yaaH family protein
VagVIO5_05830	COG1115	amino acid carrier protein
VagVIO5_05870	COG2873	o-acetylhomoserine
VagVIO5_05880	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VagVIO5_05920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VagVIO5_05920	COG3153	acetyltransferase
VagVIO5_05930	COG0583	DNA-binding transcription factor activity
VagVIO5_05950	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VagVIO5_05960	COG2867	negative regulation of translational initiation
VagVIO5_05970	COG2914	Belongs to the UPF0125 (RnfH) family
VagVIO5_05980	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VagVIO5_05990	COG0497	DNA recombination
VagVIO5_06010	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VagVIO5_06020	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VagVIO5_06030	COG1301	dicarboxylic acid transport
VagVIO5_06050	COG0484	heat shock protein binding
VagVIO5_06110	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VagVIO5_06130	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VagVIO5_06140	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VagVIO5_06140	COG0047	phosphoribosylformylglycinamidine synthase activity
VagVIO5_06170	COG1629	transport
VagVIO5_06200	COG2195	Cleaves the N-terminal amino acid of tripeptides
VagVIO5_06210	COG2252	PERMEase
VagVIO5_06220	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VagVIO5_06260	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VagVIO5_06270	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VagVIO5_06280	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VagVIO5_06290	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VagVIO5_06290	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VagVIO5_06320	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VagVIO5_06340	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VagVIO5_06350	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VagVIO5_06360	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VagVIO5_06370	COG0142	geranyltranstransferase activity
VagVIO5_06380	COG1722	exodeoxyribonuclease VII activity
VagVIO5_06390	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VagVIO5_06410	COG0301	tRNA thio-modification
VagVIO5_06410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VagVIO5_06430	COG0583	DNA-binding transcription factor activity
VagVIO5_06450	COG2363	Small membrane protein
VagVIO5_06470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VagVIO5_06480	COG1611	Belongs to the LOG family
VagVIO5_06510	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VagVIO5_06510	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VagVIO5_06530	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VagVIO5_06540	COG1464	Belongs to the NlpA lipoprotein family
VagVIO5_06550	COG2011	ABC-type metal ion transport system permease component
VagVIO5_06560	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VagVIO5_06570	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VagVIO5_06590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VagVIO5_06590	COG1263	PTS System
VagVIO5_06600	COG0366	Alpha amylase catalytic
VagVIO5_06640	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VagVIO5_06650	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VagVIO5_06660	COG0321	lipoyl(octanoyl) transferase activity
VagVIO5_06680	COG1686	Belongs to the peptidase S11 family
VagVIO5_06690	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VagVIO5_06700	COG0772	Belongs to the SEDS family
VagVIO5_06710	COG0768	penicillin binding
VagVIO5_06720	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VagVIO5_06730	COG0799	negative regulation of ribosome biogenesis
VagVIO5_06740	COG1466	dna polymerase III delta subunit
VagVIO5_06750	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VagVIO5_06760	COG0495	leucyl-tRNA aminoacylation
VagVIO5_06770	COG2888	peptidyl-tyrosine sulfation
VagVIO5_06780	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VagVIO5_06790	COG4535	Mg2 and Co2 transporter CorC
VagVIO5_06800	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VagVIO5_06810	COG1702	phosphate starvation-inducible protein PhoH
VagVIO5_06820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VagVIO5_06830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VagVIO5_06840	COG0012	GTP binding
VagVIO5_06850	COG0193	aminoacyl-tRNA hydrolase activity
VagVIO5_06860	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VagVIO5_06870	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VagVIO5_06880	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
VagVIO5_06890	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VagVIO5_06910	COG2890	protein-(glutamine-N5) methyltransferase activity
VagVIO5_06920	COG3094	Invasion gene expression up-regulator, SirB
VagVIO5_06930	COG2912	Transglutaminase-like superfamily
VagVIO5_06940	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VagVIO5_06950	COG0737	Belongs to the 5'-nucleotidase family
VagVIO5_06970	COG1187	pseudouridine synthase activity
VagVIO5_06980	COG2840	Smr protein MutS2
VagVIO5_07050	COG2608	mercury ion transmembrane transporter activity
VagVIO5_07050	COG2217	Heavy metal translocating P-type atpase
VagVIO5_07070	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VagVIO5_07170	COG0835	chemotaxis
VagVIO5_07170	COG0784	Response regulator, receiver
VagVIO5_07180	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VagVIO5_07190	COG1815	bacterial-type flagellum-dependent cell motility
VagVIO5_07200	COG1558	bacterial-type flagellum-dependent cell motility
VagVIO5_07220	COG1749	Flagellar hook protein flgE
VagVIO5_07230	COG4787	bacterial-type flagellum-dependent cell motility
VagVIO5_07250	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VagVIO5_07260	COG1706	bacterial-type flagellum-dependent cell motility
VagVIO5_07270	COG3951	Flagellar rod assembly protein muramidase FlgJ
VagVIO5_07270	COG1705	Flagellar rod assembly protein muramidase FlgJ
VagVIO5_07290	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VagVIO5_07310	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VagVIO5_07320	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VagVIO5_07330	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VagVIO5_07340	COG2190	(PTS) system
VagVIO5_07350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VagVIO5_07370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VagVIO5_07380	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VagVIO5_07390	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VagVIO5_07400	COG3115	cell septum assembly
VagVIO5_07410	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VagVIO5_07460	COG0330	HflC and HflK could
VagVIO5_07470	COG3118	belongs to the thioredoxin family
VagVIO5_07480	COG0300	oxidoreductase activity
VagVIO5_07490	COG1090	epimerase
VagVIO5_07550	COG0622	Phosphoesterase
VagVIO5_07590	COG3710	Transcriptional regulator
VagVIO5_07600	COG0326	Molecular chaperone. Has ATPase activity
VagVIO5_07620	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VagVIO5_07640	COG3104	oligopeptide transport
VagVIO5_07650	COG0250	Participates in transcription elongation, termination and antitermination
VagVIO5_07660	COG0367	asparagine synthase
VagVIO5_07670	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VagVIO5_07670	COG4651	solute:proton antiporter activity
VagVIO5_07680	COG1940	carbohydrate kinase activity
VagVIO5_07680	COG1846	Transcriptional regulator
VagVIO5_07690	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VagVIO5_07700	COG1263	PTS System
VagVIO5_07700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VagVIO5_07700	COG2190	(PTS) system
VagVIO5_07710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VagVIO5_07720	COG0735	belongs to the Fur family
VagVIO5_07740	COG0716	FMN binding
VagVIO5_07760	COG0596	Alpha beta hydrolase
VagVIO5_07770	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VagVIO5_07780	COG0033	Phosphoglucomutase
VagVIO5_07800	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VagVIO5_07830	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VagVIO5_07840	COG1053	succinate dehydrogenase
VagVIO5_07850	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VagVIO5_07860	COG0567	Dehydrogenase, E1 component
VagVIO5_07870	COG0508	dehydrogenase complex catalyzes the overall conversion of
VagVIO5_07900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VagVIO5_07910	COG1121	(ABC) transporter
VagVIO5_07920	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VagVIO5_07930	COG4977	sequence-specific DNA binding
VagVIO5_07940	COG1918	ferrous iron import across plasma membrane
VagVIO5_07980	COG0018	arginyl-trna synthetase
VagVIO5_07990	COG3102	Protein conserved in bacteria
VagVIO5_08020	COG0788	formyltetrahydrofolate deformylase activity
VagVIO5_08030	COG1199	ATP-dependent helicase activity
VagVIO5_08040	COG1214	PFAM Peptidase M22, glycoprotease
VagVIO5_08060	COG3065	identical protein binding
VagVIO5_08070	COG2267	carboxylic ester hydrolase activity
VagVIO5_08080	COG0318	PFAM AMP-dependent synthetase and ligase
VagVIO5_08090	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VagVIO5_08100	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VagVIO5_08110	COG2894	cell division
VagVIO5_08120	COG0850	regulation of cytokinetic process
VagVIO5_08130	COG3100	YcgL domain-containing protein
VagVIO5_08140	COG2951	lytic endotransglycosylase activity
VagVIO5_08160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VagVIO5_08170	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VagVIO5_08180	COG2226	methyltransferase
VagVIO5_08190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VagVIO5_08200	COG1028	Short-chain dehydrogenase reductase Sdr
VagVIO5_08220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VagVIO5_08270	COG2986	histidine ammonia-lyase
VagVIO5_08280	COG1216	Glycosyl transferase, family 2
VagVIO5_08290	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VagVIO5_08320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VagVIO5_08330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VagVIO5_08400	COG1253	flavin adenine dinucleotide binding
VagVIO5_08410	COG0513	Belongs to the DEAD box helicase family
VagVIO5_08420	COG0569	domain protein
VagVIO5_08430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VagVIO5_08460	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VagVIO5_08470	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VagVIO5_08480	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VagVIO5_08490	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VagVIO5_08520	COG0544	peptidyl-prolyl cis-trans isomerase activity
VagVIO5_08540	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VagVIO5_08550	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VagVIO5_08560	COG0776	regulation of translation
VagVIO5_08570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VagVIO5_08580	COG1555	photosystem II stabilization
VagVIO5_08610	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VagVIO5_08620	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VagVIO5_08630	COG0436	Aminotransferase
VagVIO5_08640	COG1169	isochorismate synthase
VagVIO5_08650	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VagVIO5_08660	COG0596	Alpha beta hydrolase
VagVIO5_08670	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VagVIO5_08710	COG2855	membrane
VagVIO5_08720	COG0477	Major facilitator Superfamily
VagVIO5_08750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VagVIO5_08760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VagVIO5_08800	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VagVIO5_08810	COG1522	sequence-specific DNA binding
VagVIO5_08830	COG1946	Acyl-CoA thioesterase
VagVIO5_08840	COG3126	Type III secretion system lipoprotein chaperone (YscW)
VagVIO5_08980	COG0583	DNA-binding transcription factor activity
VagVIO5_08990	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
VagVIO5_09000	COG2207	Transcriptional regulator
VagVIO5_09010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VagVIO5_09020	COG0517	IMP dehydrogenase activity
VagVIO5_09020	COG0516	GMP reductase activity
VagVIO5_09070	COG0537	adenosine 5'-monophosphoramidase activity
VagVIO5_09120	COG3150	esterase
VagVIO5_09130	COG1252	NADH dehydrogenase
VagVIO5_09160	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VagVIO5_09180	COG4591	ABC-type transport system involved in lipoprotein release permease component
VagVIO5_09190	COG1136	(ABC) transporter
VagVIO5_09200	COG4591	ABC-type transport system involved in lipoprotein release permease component
VagVIO5_09220	COG0658	competence protein
VagVIO5_09220	COG2333	competence protein COMEC
VagVIO5_09230	COG1132	(ABC) transporter
VagVIO5_09240	COG1663	tetraacyldisaccharide 4'-kinase activity
VagVIO5_09270	COG2719	SpoVR family
VagVIO5_09280	COG2718	Belongs to the UPF0229 family
VagVIO5_09290	COG2766	serine protein kinase
VagVIO5_09300	COG3013	Belongs to the UPF0304 family
VagVIO5_09320	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VagVIO5_09340	COG1882	Formate acetyltransferase
VagVIO5_09420	COG0708	Exodeoxyribonuclease III
VagVIO5_09440	COG3923	Primosomal replication protein n
VagVIO5_09450	COG0730	response to heat
VagVIO5_09460	COG1199	ATP-dependent helicase activity
VagVIO5_09470	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VagVIO5_09480	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VagVIO5_09490	COG1187	pseudouridine synthase activity
VagVIO5_09510	COG1278	Cold shock
VagVIO5_09520	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VagVIO5_09530	COG0542	response to heat
VagVIO5_09540	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VagVIO5_09550	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VagVIO5_09560	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VagVIO5_09600	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VagVIO5_09610	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VagVIO5_09620	COG0297	glycogen (starch) synthase activity
VagVIO5_09660	COG3070	regulator of competence-specific genes
VagVIO5_09670	COG1609	Transcriptional regulator
VagVIO5_09680	COG3381	protein complex oligomerization
VagVIO5_09690	COG0745	RESPONSE REGULATOR receiver
VagVIO5_09700	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VagVIO5_09710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VagVIO5_09730	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VagVIO5_09740	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VagVIO5_09780	COG4067	protein conserved in archaea
VagVIO5_09780	COG0189	ligase activity
VagVIO5_09790	COG0500	methyltransferase
VagVIO5_09810	COG1801	Protein of unknown function DUF72
VagVIO5_09830	COG0217	transcriptional regulatory protein
VagVIO5_09840	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VagVIO5_09850	COG0632	four-way junction helicase activity
VagVIO5_09860	COG2255	four-way junction helicase activity
VagVIO5_09870	COG1271	oxidase subunit
VagVIO5_09880	COG1294	oxidase, subunit
VagVIO5_09890	COG4890	Cyd operon protein YbgT
VagVIO5_09910	COG0824	Thioesterase
VagVIO5_09920	COG0811	peptide transport
VagVIO5_09950	COG0823	Involved in the tonB-independent uptake of proteins
VagVIO5_09960	COG2885	chlorophyll binding
VagVIO5_09970	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VagVIO5_09980	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VagVIO5_10000	COG3766	membrane
VagVIO5_10020	COG0754	glutathionylspermidine amidase activity
VagVIO5_10040	COG0784	Response regulator, receiver
VagVIO5_10040	COG5002	protein histidine kinase activity
VagVIO5_10060	COG0840	transmembrane signaling receptor activity
VagVIO5_10070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VagVIO5_10080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VagVIO5_10130	COG3568	Endonuclease Exonuclease Phosphatase
VagVIO5_10150	COG0840	transmembrane signaling receptor activity
VagVIO5_10180	COG0583	DNA-binding transcription factor activity
VagVIO5_10200	COG0686	Belongs to the AlaDH PNT family
VagVIO5_10220	COG1674	ftsk spoiiie
VagVIO5_10230	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VagVIO5_10240	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VagVIO5_10250	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VagVIO5_10310	COG2226	methyltransferase
VagVIO5_10310	COG1073	alpha beta
VagVIO5_10320	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VagVIO5_10370	COG0300	oxidoreductase activity
VagVIO5_10400	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VagVIO5_10420	COG2268	Band 7 protein
VagVIO5_10440	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VagVIO5_10450	COG2915	High frequency lysogenization protein hflD homolog
VagVIO5_10460	COG0482	sulfurtransferase activity
VagVIO5_10480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VagVIO5_10500	COG1757	Na H antiporter
VagVIO5_10520	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VagVIO5_10530	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VagVIO5_10540	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VagVIO5_10550	COG0131	Imidazoleglycerol-phosphate dehydratase
VagVIO5_10550	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VagVIO5_10560	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VagVIO5_10570	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VagVIO5_10590	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VagVIO5_10590	COG0140	phosphoribosyl-ATP diphosphatase activity
VagVIO5_10670	COG3850	Histidine kinase
VagVIO5_10670	COG5002	protein histidine kinase activity
VagVIO5_10680	COG0745	RESPONSE REGULATOR receiver
VagVIO5_10690	COG0840	transmembrane signaling receptor activity
VagVIO5_10720	COG1032	radical SAM domain protein
VagVIO5_10730	COG5001	Diguanylate cyclase
VagVIO5_10760	COG0583	DNA-binding transcription factor activity
VagVIO5_10770	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VagVIO5_10790	COG2350	Protein conserved in bacteria
VagVIO5_10810	COG2917	probably involved in intracellular septation
VagVIO5_10850	COG1301	dicarboxylic acid transport
VagVIO5_10860	COG0318	PFAM AMP-dependent synthetase and ligase
VagVIO5_10870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VagVIO5_10880	COG0159	tryptophan synthase activity
VagVIO5_10900	COG0134	indole-3-glycerol-phosphate synthase activity
VagVIO5_10900	COG0135	phosphoribosylanthranilate isomerase activity
VagVIO5_10920	COG0512	Glutamine amidotransferase of anthranilate synthase
VagVIO5_10930	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VagVIO5_10950	COG0613	PHP domain protein
VagVIO5_10960	COG0009	L-threonylcarbamoyladenylate synthase
VagVIO5_10990	COG1187	pseudouridine synthase activity
VagVIO5_11030	COG0417	DNA replication proofreading
VagVIO5_11040	COG2197	response regulator
VagVIO5_11050	COG0322	excinuclease ABC activity
VagVIO5_11090	COG0019	diaminopimelate decarboxylase activity
VagVIO5_11150	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VagVIO5_11160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VagVIO5_11210	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VagVIO5_11230	COG0437	4 iron, 4 sulfur cluster binding
VagVIO5_11240	COG3301	Polysulphide reductase, NrfD
VagVIO5_11250	COG1138	Cytochrome C-type biogenesis protein
VagVIO5_11270	COG3088	subunit of a heme lyase
VagVIO5_11270	COG4235	cytochrome complex assembly
VagVIO5_11290	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VagVIO5_11340	COG2989	Protein conserved in bacteria
VagVIO5_11350	COG3108	Peptidase M15
VagVIO5_11360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VagVIO5_11390	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VagVIO5_11450	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VagVIO5_11460	COG0840	transmembrane signaling receptor activity
VagVIO5_11500	COG1448	Aminotransferase
VagVIO5_11530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VagVIO5_11550	COG0017	Asparaginyl-tRNA synthetase
VagVIO5_11560	COG0840	transmembrane signaling receptor activity
VagVIO5_11580	COG0720	synthase
VagVIO5_11600	COG2200	EAL domain
VagVIO5_11610	COG1760	l-serine dehydratase
VagVIO5_11620	COG0814	amino acid
VagVIO5_11630	COG0494	nUDIX hydrolase
VagVIO5_11650	COG0784	Response regulator, receiver
VagVIO5_11650	COG2205	protein histidine kinase activity
VagVIO5_11660	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VagVIO5_11690	COG3106	COG3106 Predicted ATPase
VagVIO5_11700	COG3768	UPF0283 membrane protein
VagVIO5_11720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VagVIO5_12170	COG0729	surface antigen
VagVIO5_12180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VagVIO5_12190	COG2272	Belongs to the type-B carboxylesterase lipase family
VagVIO5_12260	COG2985	domain, Protein
VagVIO5_12280	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
VagVIO5_12310	COG0583	DNA-binding transcription factor activity
VagVIO5_12370	COG0210	DNA helicase
VagVIO5_12400	COG4735	regulation of single-species biofilm formation
VagVIO5_12470	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
VagVIO5_12480	COG2944	sequence-specific DNA binding
VagVIO5_12550	COG1566	PFAM secretion protein HlyD family protein
VagVIO5_12580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VagVIO5_12610	COG3290	protein histidine kinase activity
VagVIO5_12620	COG4565	transcriptional regulatory protein
VagVIO5_12630	COG4774	siderophore transport
VagVIO5_12650	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VagVIO5_12660	COG0363	glucosamine-6-phosphate deaminase activity
VagVIO5_12670	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VagVIO5_12700	COG3284	Transcriptional regulator
VagVIO5_12710	COG1012	belongs to the aldehyde dehydrogenase family
VagVIO5_12850	COG4669	(LipO)protein
VagVIO5_12890	COG3177	Filamentation induced by cAMP protein fic
VagVIO5_12950	COG1028	Short-chain dehydrogenase reductase Sdr
VagVIO5_13000	COG4792	protein secretion
VagVIO5_13010	COG4791	protein targeting
VagVIO5_13020	COG4794	Type iii secretion
VagVIO5_13030	COG4790	Type iii secretion
VagVIO5_13170	COG0457	Tetratricopeptide repeat
VagVIO5_13210	COG2358	TRAP transporter, solute receptor (TAXI family
VagVIO5_13220	COG0730	response to heat
VagVIO5_13290	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VagVIO5_13300	COG0372	Belongs to the citrate synthase family
VagVIO5_13320	COG2828	Protein conserved in bacteria
VagVIO5_13370	COG0561	phosphatase activity
VagVIO5_13380	COG0602	queuosine metabolic process
VagVIO5_13390	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VagVIO5_13400	COG3706	GGDEF domain
VagVIO5_13500	COG1254	Belongs to the acylphosphatase family
VagVIO5_13510	COG2920	part of a sulfur-relay system
VagVIO5_13530	COG0670	Belongs to the BI1 family
VagVIO5_13540	COG1126	abc transporter atp-binding protein
VagVIO5_13550	COG0765	amino acid transport
VagVIO5_13560	COG4597	amino acid ABC transporter
VagVIO5_13570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VagVIO5_13590	COG1666	GTP binding
VagVIO5_13600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VagVIO5_13650	COG3008	intermembrane lipid transfer
VagVIO5_13660	COG2995	paraquat-inducible protein a
VagVIO5_13670	COG1132	(ABC) transporter
VagVIO5_13680	COG1956	GAF domain-containing protein
VagVIO5_13690	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VagVIO5_13720	COG0308	aminopeptidase N
VagVIO5_13740	COG2902	Dehydrogenase
VagVIO5_13750	COG0167	dihydroorotate dehydrogenase activity
VagVIO5_13770	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VagVIO5_13770	COG0116	Belongs to the methyltransferase superfamily
VagVIO5_13820	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VagVIO5_13830	COG1067	ATP-dependent peptidase activity
VagVIO5_13840	COG3120	sequence-specific DNA binding
VagVIO5_14110	COG0784	Response regulator, receiver
VagVIO5_14110	COG2205	protein histidine kinase activity
VagVIO5_14140	COG3278	Belongs to the heme-copper respiratory oxidase family
VagVIO5_14170	COG2010	Cytochrome c
VagVIO5_14190	COG2217	Heavy metal translocating P-type atpase
VagVIO5_14220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VagVIO5_14230	COG0589	response to stress
VagVIO5_14280	COG3842	ATPase activity
VagVIO5_14300	COG1177	transmembrane transport
VagVIO5_14320	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VagVIO5_14330	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VagVIO5_14350	COG0004	ammonium transporteR
VagVIO5_14400	COG0437	4 iron, 4 sulfur cluster binding
VagVIO5_14410	COG3383	formate dehydrogenase (NAD+) activity
VagVIO5_14410	COG0243	molybdopterin cofactor binding
VagVIO5_14430	COG3381	protein complex oligomerization
VagVIO5_14470	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VagVIO5_14490	COG0488	(ABC) transporter
VagVIO5_14500	COG4191	Histidine kinase
VagVIO5_14510	COG2204	response regulator
VagVIO5_14540	COG3842	ATPase activity
VagVIO5_14550	COG0746	molybdenum cofactor guanylyltransferase activity
VagVIO5_14580	COG1940	carbohydrate kinase activity
VagVIO5_14650	COG0791	NLP P60 protein
VagVIO5_14670	COG3706	GGDEF domain
VagVIO5_14690	COG3001	Fructosamine kinase
VagVIO5_14710	COG0307	riboflavin synthase, alpha
VagVIO5_14720	COG0534	Mate efflux family protein
VagVIO5_14740	COG1793	dna ligase
VagVIO5_14800	COG2204	response regulator
VagVIO5_14820	COG0438	transferase activity, transferring glycosyl groups
VagVIO5_14880	COG0438	transferase activity, transferring glycosyl groups
VagVIO5_14890	COG1215	transferase activity, transferring glycosyl groups
VagVIO5_14900	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VagVIO5_14920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VagVIO5_14950	COG1643	Atp-dependent helicase
VagVIO5_14960	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VagVIO5_15050	COG0443	Heat shock 70 kDa protein
VagVIO5_15060	COG0443	Heat shock 70 kDa protein
VagVIO5_15100	COG4968	Prepilin-type N-terminal cleavage methylation domain
VagVIO5_15110	COG1132	(ABC) transporter
VagVIO5_15120	COG1132	(ABC) transporter
VagVIO5_15140	COG4774	siderophore transport
VagVIO5_15150	COG4774	siderophore transport
VagVIO5_15170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VagVIO5_15180	COG1120	ATPase activity
VagVIO5_15210	COG0814	amino acid
VagVIO5_15230	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VagVIO5_15250	COG0861	Integral membrane protein TerC family
VagVIO5_15270	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VagVIO5_15280	COG1328	CTP reductase activity
VagVIO5_15310	COG3300	MHYT domain
VagVIO5_15310	COG5001	Diguanylate cyclase
VagVIO5_15330	COG4191	Histidine kinase
VagVIO5_15340	COG0471	metal ion transport
VagVIO5_15390	COG4702	Belongs to the UPF0303 family
VagVIO5_15400	COG0673	inositol 2-dehydrogenase activity
VagVIO5_15440	COG0641	radical SAM
VagVIO5_15480	COG3119	arylsulfatase activity
VagVIO5_15490	COG0527	aspartate kinase activity
VagVIO5_15500	COG0662	Cupin 2, conserved barrel domain protein
VagVIO5_15510	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VagVIO5_15520	COG0456	acetyltransferase
VagVIO5_15530	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VagVIO5_15570	COG4176	ABC-type proline glycine betaine transport system permease component
VagVIO5_15580	COG2113	Glycine betaine
VagVIO5_15620	COG1028	Short-chain dehydrogenase reductase Sdr
VagVIO5_15640	COG0745	RESPONSE REGULATOR receiver
VagVIO5_15650	COG0642	Histidine kinase
VagVIO5_15660	COG1368	sulfuric ester hydrolase activity
VagVIO5_15740	COG1115	amino acid carrier protein
VagVIO5_15760	COG1280	lysine exporter protein (LysE YggA)
VagVIO5_15770	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VagVIO5_15840	COG1162	GTPase activity
VagVIO5_15870	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VagVIO5_15880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VagVIO5_15890	COG1160	GTP binding
VagVIO5_15900	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
VagVIO5_15920	COG1160	GTP binding
VagVIO5_15990	COG1570	exodeoxyribonuclease VII activity
VagVIO5_16080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VagVIO5_16100	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VagVIO5_16170	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
VagVIO5_16180	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VagVIO5_16190	COG1560	Kdo2-lipid A biosynthetic process
VagVIO5_16210	COG0531	amino acid
VagVIO5_16240	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
VagVIO5_16250	COG3063	Type IV pilus biogenesis stability protein PilW
VagVIO5_16310	COG0110	maltose O-acetyltransferase activity
VagVIO5_16340	COG2315	Protein conserved in bacteria
VagVIO5_16350	COG1846	Transcriptional regulator
VagVIO5_16370	COG2200	EAL domain
VagVIO5_16420	COG0625	glutathione transferase activity
VagVIO5_16440	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VagVIO5_16460	COG2195	Cleaves the N-terminal amino acid of tripeptides
VagVIO5_16480	COG0601	transmembrane transport
VagVIO5_16490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VagVIO5_16530	COG3291	Pkd domain containing protein
VagVIO5_16560	COG1177	transmembrane transport
VagVIO5_16570	COG1176	ABC-type spermidine putrescine transport system, permease component I
VagVIO5_16580	COG3842	ATPase activity
VagVIO5_16590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VagVIO5_16600	COG2423	ornithine cyclodeaminase activity
VagVIO5_16630	COG3938	Belongs to the proline racemase family
VagVIO5_16690	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
VagVIO5_16700	COG1451	nucleotide metabolic process
VagVIO5_16720	COG0583	DNA-binding transcription factor activity
VagVIO5_16760	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
VagVIO5_16770	COG4139	cobalamin transport
VagVIO5_16780	COG2988	succinylglutamate desuccinylase activity
VagVIO5_16820	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VagVIO5_16830	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VagVIO5_16840	COG0702	epimerase
VagVIO5_16860	COG2925	Exonuclease
VagVIO5_16870	COG1380	Effector of murein hydrolase LrgA
VagVIO5_16880	COG1346	cytolysis
VagVIO5_16890	COG0295	cytidine deaminase activity
VagVIO5_16900	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VagVIO5_16910	COG0500	methyltransferase
VagVIO5_16930	COG0776	regulation of translation
VagVIO5_16950	COG0072	phenylalanine-tRNA ligase activity
VagVIO5_16950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VagVIO5_16960	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VagVIO5_17020	COG0393	Putative heavy-metal-binding
VagVIO5_17040	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VagVIO5_17060	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VagVIO5_17090	COG2188	Transcriptional regulator
VagVIO5_17100	COG1228	amidohydrolase
VagVIO5_17110	COG0010	Belongs to the arginase family
VagVIO5_17120	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VagVIO5_17130	COG2986	histidine ammonia-lyase
VagVIO5_17160	COG0247	lactate metabolic process
VagVIO5_17160	COG0277	FAD linked oxidase domain protein
VagVIO5_17230	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VagVIO5_17260	COG1643	Atp-dependent helicase
VagVIO5_17270	COG0281	malic enzyme
VagVIO5_17280	COG2949	membrane
VagVIO5_17290	COG0471	metal ion transport
VagVIO5_17300	COG0471	metal ion transport
VagVIO5_17360	COG0492	ferredoxin-NADP+ reductase activity
VagVIO5_17370	COG4988	ABC transporter
VagVIO5_17380	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VagVIO5_17400	COG2885	chlorophyll binding
VagVIO5_17440	COG3121	Chaperone
VagVIO5_17460	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VagVIO5_17480	COG4191	Histidine kinase
VagVIO5_17480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VagVIO5_17520	COG3070	regulator of competence-specific genes
VagVIO5_17540	COG2431	L-lysine efflux transmembrane transporter activity
VagVIO5_17560	COG0076	glutamate decarboxylase activity
VagVIO5_17570	COG1737	Transcriptional regulator
VagVIO5_17590	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VagVIO5_17600	COG2985	domain, Protein
VagVIO5_17600	COG3273	potassium ion transport
VagVIO5_17610	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VagVIO5_17620	COG1960	acyl-CoA dehydrogenase activity
VagVIO5_17640	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VagVIO5_17680	COG0534	Mate efflux family protein
VagVIO5_17690	COG0702	epimerase
VagVIO5_17700	COG3005	denitrification pathway
VagVIO5_17760	COG2814	Major facilitator Superfamily
VagVIO5_17770	COG1187	pseudouridine synthase activity
VagVIO5_17780	COG1061	Type III restriction enzyme res subunit
VagVIO5_17800	COG0745	RESPONSE REGULATOR receiver
VagVIO5_17810	COG2205	protein histidine kinase activity
VagVIO5_17820	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VagVIO5_17870	COG4134	Bacterial extracellular solute-binding protein
VagVIO5_17880	COG4135	transport system, permease component
VagVIO5_17890	COG4136	ATPase activity
VagVIO5_17900	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VagVIO5_17920	COG3604	Transcriptional regulator
VagVIO5_17930	COG1151	hydroxylamine reductase activity
VagVIO5_17940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VagVIO5_17960	COG0564	pseudouridine synthase activity
VagVIO5_17970	COG0733	neurotransmitter:sodium symporter activity
VagVIO5_17980	COG0733	neurotransmitter:sodium symporter activity
VagVIO5_18000	COG0626	cystathionine gamma-synthase activity
VagVIO5_18010	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
VagVIO5_18020	COG5380	lipid catabolic process
VagVIO5_18030	COG2818	Glycosylase
VagVIO5_18070	COG1983	PspC domain protein
VagVIO5_18090	COG1842	Phage shock protein A
VagVIO5_18100	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VagVIO5_18130	COG4171	peptide transport system, permease
VagVIO5_18150	COG4172	Belongs to the ABC transporter superfamily
VagVIO5_18170	COG1227	inorganic diphosphatase activity
VagVIO5_18200	COG0243	molybdopterin cofactor binding
VagVIO5_18210	COG3005	denitrification pathway
VagVIO5_18220	COG4459	periplasmic nitrate reductase
VagVIO5_18230	COG0390	transport system, permease component
VagVIO5_18250	COG2116	formate transmembrane transporter activity
VagVIO5_18300	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VagVIO5_18310	COG1435	thymidine kinase activity
VagVIO5_18320	COG0215	cysteine-tRNA ligase activity
VagVIO5_18330	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VagVIO5_18340	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VagVIO5_18350	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VagVIO5_18360	COG3012	SEC-C Motif Domain Protein
VagVIO5_18420	COG0577	efflux transmembrane transporter activity
VagVIO5_18420	COG1136	(ABC) transporter
VagVIO5_18440	COG0577	efflux transmembrane transporter activity
VagVIO5_18440	COG1136	(ABC) transporter
VagVIO5_18460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VagVIO5_18510	COG3118	belongs to the thioredoxin family
VagVIO5_18520	COG4232	protein-disulfide reductase activity
VagVIO5_18590	COG2863	cytochrome
VagVIO5_18600	COG3258	Cytochrome c
VagVIO5_18610	COG2995	paraquat-inducible protein a
VagVIO5_18620	COG3008	intermembrane lipid transfer
VagVIO5_18620	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VagVIO5_18650	COG4166	transmembrane transport
VagVIO5_18670	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VagVIO5_18680	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VagVIO5_18700	COG0539	negative regulation of cytoplasmic translation
VagVIO5_18710	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VagVIO5_18720	COG0616	signal peptide processing
VagVIO5_18730	COG1028	Short-chain dehydrogenase reductase Sdr
VagVIO5_18760	COG0587	DNA-directed DNA polymerase activity
VagVIO5_18770	COG0835	chemotaxis
VagVIO5_18770	COG0784	Response regulator, receiver
VagVIO5_18780	COG1940	carbohydrate kinase activity
VagVIO5_18790	COG0469	pyruvate kinase activity
VagVIO5_18800	COG4667	esterase of the alpha-beta hydrolase superfamily
VagVIO5_18830	COG0733	neurotransmitter:sodium symporter activity
VagVIO5_18860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VagVIO5_18860	COG1263	PTS System
VagVIO5_18870	COG0084	hydrolase, TatD family'
VagVIO5_18880	COG0470	DNA polymerase III
VagVIO5_18890	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VagVIO5_18900	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VagVIO5_18960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VagVIO5_18970	COG0416	fatty acid biosynthetic process
VagVIO5_18990	COG1399	metal-binding, possibly nucleic acid-binding protein
VagVIO5_19000	COG0424	maF-like protein
VagVIO5_19010	COG0564	pseudouridine synthase activity
VagVIO5_19020	COG1530	ribonuclease E activity
VagVIO5_19030	COG0659	secondary active sulfate transmembrane transporter activity
VagVIO5_19040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VagVIO5_19050	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VagVIO5_19070	COG0572	uridine kinase
VagVIO5_19120	COG2186	Transcriptional regulator
VagVIO5_19130	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VagVIO5_19140	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VagVIO5_19150	COG0653	protein targeting
VagVIO5_19160	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VagVIO5_19170	COG3706	GGDEF domain
VagVIO5_19180	COG0366	Alpha amylase catalytic
VagVIO5_19190	COG1122	ATPase activity
VagVIO5_19200	COG4120	Belongs to the binding-protein-dependent transport system permease family
VagVIO5_19220	COG3092	negative regulation of chromosome organization
VagVIO5_19230	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VagVIO5_19240	COG0857	belongs to the CobB CobQ family
VagVIO5_19240	COG0280	phosphate acetyltransferase
VagVIO5_19250	COG3174	membrane
VagVIO5_19270	COG0435	Glutathione S-transferase
VagVIO5_19290	COG0444	Belongs to the ABC transporter superfamily
VagVIO5_19300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VagVIO5_19310	COG0601	transmembrane transport
VagVIO5_19330	COG0314	molybdopterin synthase activity
VagVIO5_19340	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VagVIO5_19350	COG0315	cyclic pyranopterin monophosphate synthase activity
VagVIO5_19360	COG0521	Mo-molybdopterin cofactor biosynthetic process
VagVIO5_19370	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VagVIO5_19380	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VagVIO5_19390	COG2198	Histidine kinase
VagVIO5_19400	COG2204	response regulator
VagVIO5_19410	COG0556	nucleotide-excision repair
VagVIO5_19420	COG4657	Part of a membrane complex involved in electron transport
VagVIO5_19430	COG2878	Part of a membrane complex involved in electron transport
VagVIO5_19440	COG4656	Part of a membrane complex involved in electron transport
VagVIO5_19450	COG4658	electron transport chain
VagVIO5_19460	COG4659	FMN binding
VagVIO5_19470	COG4660	Part of a membrane complex involved in electron transport
VagVIO5_19480	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VagVIO5_19490	COG0346	lactoylglutathione lyase activity
VagVIO5_19510	COG2885	chlorophyll binding
VagVIO5_19530	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VagVIO5_19540	COG2056	Na+-H+ antiporter family
VagVIO5_19560	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VagVIO5_19600	COG1454	alcohol dehydrogenase
VagVIO5_19600	COG1012	belongs to the aldehyde dehydrogenase family
VagVIO5_19610	COG2095	MarC family integral membrane protein
VagVIO5_19620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VagVIO5_19630	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VagVIO5_19640	COG1757	Na H antiporter
VagVIO5_19670	COG3081	Nucleoid-associated protein
VagVIO5_19680	COG3082	Protein of unknown function (DUF1414)
VagVIO5_19700	COG0123	including yeast histone deacetylase and acetoin utilization protein
VagVIO5_19730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VagVIO5_19740	COG0778	Nitroreductase
VagVIO5_19760	COG1902	pentaerythritol trinitrate reductase activity
VagVIO5_19760	COG0446	pyridine nucleotide-disulphide oxidoreductase
VagVIO5_19770	COG0616	signal peptide processing
VagVIO5_19780	COG0252	asparaginase activity
VagVIO5_19790	COG3139	Protein of unknown function (DUF1315)
VagVIO5_19810	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VagVIO5_19820	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VagVIO5_19850	COG2226	methyltransferase
VagVIO5_19880	COG1785	Belongs to the alkaline phosphatase family
VagVIO5_19900	COG0346	lactoylglutathione lyase activity
VagVIO5_19910	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
VagVIO5_19920	COG0668	transmembrane transport
VagVIO5_19930	COG2983	Belongs to the UPF0260 family
VagVIO5_19940	COG2261	transglycosylase associated protein
VagVIO5_19970	COG3681	Belongs to the UPF0597 family
VagVIO5_19980	COG0251	oxidation-reduction process
VagVIO5_19990	COG0814	amino acid
VagVIO5_20000	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VagVIO5_20010	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VagVIO5_20040	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VagVIO5_20050	COG2832	Protein of unknown function (DUF454)
VagVIO5_20070	COG0745	RESPONSE REGULATOR receiver
VagVIO5_20080	COG0583	DNA-binding transcription factor activity
VagVIO5_20090	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VagVIO5_20100	COG1286	toxin biosynthetic process
VagVIO5_20110	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VagVIO5_20120	COG0285	dihydrofolate synthase activity
VagVIO5_20130	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VagVIO5_20140	COG0101	tRNA pseudouridine synthase activity
VagVIO5_20160	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VagVIO5_20170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VagVIO5_20180	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VagVIO5_20190	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VagVIO5_20190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VagVIO5_20200	COG0431	NADPH-dependent FMN reductase
VagVIO5_20220	COG3101	peptidyl-lysine hydroxylation
VagVIO5_20230	COG2860	membrane
VagVIO5_20240	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VagVIO5_20250	COG2890	protein-(glutamine-N5) methyltransferase activity
VagVIO5_20260	COG2840	Smr protein MutS2
VagVIO5_20270	COG2062	phosphohistidine phosphatase, SixA
VagVIO5_20300	COG1250	3-hydroxyacyl-CoA dehydrogenase
VagVIO5_20300	COG1024	Enoyl-CoA hydratase
VagVIO5_20310	COG0183	Belongs to the thiolase family
VagVIO5_20350	COG2067	long-chain fatty acid transport protein
VagVIO5_20370	COG3088	subunit of a heme lyase
VagVIO5_20370	COG4235	cytochrome complex assembly
VagVIO5_20390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VagVIO5_20400	COG1138	Cytochrome C-type biogenesis protein
VagVIO5_20410	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VagVIO5_20420	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VagVIO5_20430	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VagVIO5_20440	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VagVIO5_20450	COG4133	protoheme IX ABC transporter activity
VagVIO5_20470	COG0835	chemotaxis
VagVIO5_20490	COG1192	Involved in chromosome partitioning
VagVIO5_20500	COG2201	protein-glutamate methylesterase activity
VagVIO5_20510	COG2198	Histidine kinase
VagVIO5_20510	COG0784	Response regulator, receiver
VagVIO5_20510	COG0643	Histidine kinase
VagVIO5_20520	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VagVIO5_20600	COG1987	bacterial-type flagellum assembly
VagVIO5_20700	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VagVIO5_20720	COG1677	Flagellar hook-basal body complex protein FliE
VagVIO5_20740	COG4191	Histidine kinase
VagVIO5_20760	COG1516	flagellar protein fliS
VagVIO5_20780	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VagVIO5_20790	COG1334	flagellar protein FlaG
VagVIO5_20800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VagVIO5_20810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VagVIO5_20820	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VagVIO5_20830	COG2837	iron assimilation
VagVIO5_20880	COG1393	Belongs to the ArsC family
VagVIO5_20890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VagVIO5_20930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VagVIO5_20950	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VagVIO5_20980	COG4783	chaperone-mediated protein folding
VagVIO5_20990	COG1393	Belongs to the ArsC family
VagVIO5_21030	COG2233	PERMEase
VagVIO5_21040	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VagVIO5_21050	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VagVIO5_21060	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VagVIO5_21070	COG0121	glutamine amidotransferase
VagVIO5_21080	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VagVIO5_21090	COG1960	acyl-CoA dehydrogenase activity
VagVIO5_21160	COG0328	RNA-DNA hybrid ribonuclease activity
VagVIO5_21170	COG2226	methyltransferase
VagVIO5_21180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VagVIO5_21190	COG1388	LysM domain
VagVIO5_21190	COG0741	lytic transglycosylase activity
VagVIO5_21210	COG3021	interspecies interaction between organisms
VagVIO5_21220	COG0347	Belongs to the P(II) protein family
VagVIO5_21250	COG0825	malonyl-CoA metabolic process
VagVIO5_21260	COG0587	DNA-directed DNA polymerase activity
VagVIO5_21280	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VagVIO5_21290	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VagVIO5_21310	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VagVIO5_21320	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VagVIO5_21340	COG0750	zinc metalloprotease
VagVIO5_21350	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VagVIO5_21360	COG0575	Belongs to the CDS family
VagVIO5_21370	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VagVIO5_21380	COG0233	cytoplasmic translational termination
VagVIO5_21390	COG0528	UMP kinase activity
VagVIO5_21400	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VagVIO5_21410	COG0052	Belongs to the universal ribosomal protein uS2 family
VagVIO5_21420	COG0024	Methionine aminopeptidase
VagVIO5_21430	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VagVIO5_21450	COG0564	pseudouridine synthase activity
VagVIO5_21520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VagVIO5_21530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VagVIO5_21580	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VagVIO5_21590	COG0254	rRNA binding
VagVIO5_21600	COG1720	tRNA m6t6A37 methyltransferase activity
VagVIO5_21610	COG0442	prolyl-tRNA aminoacylation
VagVIO5_21650	COG0733	neurotransmitter:sodium symporter activity
VagVIO5_21680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VagVIO5_21690	COG0514	ATP-dependent DNA helicase (RecQ)
VagVIO5_21700	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VagVIO5_21730	COG1477	protein flavinylation
VagVIO5_21740	COG2871	sodium ion transport
VagVIO5_21750	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VagVIO5_21760	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VagVIO5_21770	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VagVIO5_21780	COG1805	sodium ion transport
VagVIO5_21790	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VagVIO5_21800	COG0271	Belongs to the BolA IbaG family
VagVIO5_21810	COG2813	Specifically methylates the guanine in position
VagVIO5_21820	COG3056	Lipoprotein
VagVIO5_21860	COG1595	DNA-templated transcription, initiation
VagVIO5_21900	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VagVIO5_21910	COG0693	protein deglycase activity
VagVIO5_21920	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VagVIO5_21930	COG3706	GGDEF domain
VagVIO5_21950	COG2166	iron-sulfur cluster assembly
VagVIO5_21960	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VagVIO5_21970	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VagVIO5_21990	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VagVIO5_21990	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VagVIO5_22030	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VagVIO5_22040	COG1074	ATP-dependent DNA helicase activity
VagVIO5_22050	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VagVIO5_22090	COG3141	response to X-ray
VagVIO5_22100	COG2171	N-acyltransferase activity
VagVIO5_22110	COG0584	glycerophosphoryl diester phosphodiesterase
VagVIO5_22120	COG2271	Major facilitator Superfamily
VagVIO5_22130	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VagVIO5_22140	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VagVIO5_22150	COG1349	DNA-binding transcription factor activity
VagVIO5_22160	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VagVIO5_22200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VagVIO5_22210	COG1609	Transcriptional regulator
VagVIO5_22220	COG2211	Major facilitator Superfamily
VagVIO5_22250	COG2017	converts alpha-aldose to the beta-anomer
VagVIO5_22260	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VagVIO5_22280	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VagVIO5_22290	COG1609	Transcriptional regulator
VagVIO5_22300	COG3250	beta-galactosidase activity
VagVIO5_22310	COG2731	YhcH YjgK YiaL family protein
VagVIO5_22320	COG0531	amino acid
VagVIO5_22330	COG0583	DNA-binding transcription factor activity
VagVIO5_22450	COG4964	Belongs to the GSP D family
VagVIO5_22500	COG2169	Transcriptional regulator
VagVIO5_22510	COG1022	Amp-dependent synthetase and ligase
VagVIO5_22530	COG0583	DNA-binding transcription factor activity
VagVIO5_22540	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VagVIO5_22550	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VagVIO5_22570	COG0560	Phosphoserine phosphatase
VagVIO5_22590	COG0813	purine-nucleoside phosphorylase activity
VagVIO5_22600	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VagVIO5_22610	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VagVIO5_22630	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VagVIO5_22640	COG0084	hydrolase, TatD family'
VagVIO5_22660	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VagVIO5_22810	COG0191	fructose-bisphosphate aldolase activity
VagVIO5_22860	COG0501	Belongs to the peptidase M48B family
VagVIO5_22890	COG0542	response to heat
VagVIO5_22920	COG0443	Heat shock 70 kDa protein
VagVIO5_22930	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VagVIO5_22960	COG0071	Belongs to the small heat shock protein (HSP20) family
VagVIO5_22970	COG0071	Belongs to the small heat shock protein (HSP20) family
VagVIO5_23090	COG2003	Belongs to the UPF0758 family
VagVIO5_23140	COG0714	Associated with various cellular activities
VagVIO5_23180	COG0629	single-stranded DNA binding
VagVIO5_23220	COG3385	transposase activity
VagVIO5_23240	COG3344	reverse transcriptase
VagVIO5_23270	COG0668	transmembrane transport
VagVIO5_23280	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VagVIO5_23370	COG0681	Belongs to the peptidase S26 family
VagVIO5_23400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VagVIO5_23640	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VagVIO5_23760	COG3153	acetyltransferase
VagVIO5_23770	COG3154	lipid carrier protein
VagVIO5_23790	COG0826	peptidase U32
VagVIO5_23800	COG0826	peptidase U32
VagVIO5_23810	COG0534	Mate efflux family protein
VagVIO5_23840	COG1185	polyribonucleotide nucleotidyltransferase activity
VagVIO5_23850	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VagVIO5_23860	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VagVIO5_23870	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VagVIO5_23880	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VagVIO5_23890	COG0195	Participates in both transcription termination and antitermination
VagVIO5_23900	COG0779	Required for maturation of 30S ribosomal subunits
VagVIO5_23910	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VagVIO5_23920	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VagVIO5_23930	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VagVIO5_23940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VagVIO5_23950	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VagVIO5_23960	COG1534	Rna-binding protein
VagVIO5_23970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VagVIO5_23980	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VagVIO5_23990	COG2027	D-alanyl-D-alanine carboxypeptidase
VagVIO5_24010	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VagVIO5_24020	COG0739	heme binding
VagVIO5_24060	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VagVIO5_24070	COG0628	permease
VagVIO5_24090	COG0784	Response regulator, receiver
VagVIO5_24090	COG2205	protein histidine kinase activity
VagVIO5_24100	COG0747	negative chemotaxis
VagVIO5_24130	COG0444	Belongs to the ABC transporter superfamily
VagVIO5_24140	COG4608	Belongs to the ABC transporter superfamily
VagVIO5_24160	COG2971	BadF BadG BcrA BcrD
VagVIO5_24190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VagVIO5_24200	COG3842	ATPase activity
VagVIO5_24220	COG1840	ABC-type Fe3 transport system, periplasmic component
VagVIO5_24230	COG0004	ammonium transporteR
VagVIO5_24240	COG0347	Belongs to the P(II) protein family
VagVIO5_24250	COG3112	Uncharacterised protein family (UPF0231)
VagVIO5_24260	COG1049	propionate catabolic process, 2-methylcitrate cycle
VagVIO5_24270	COG1752	Esterase of the alpha-beta hydrolase superfamily
VagVIO5_24280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VagVIO5_24290	COG1643	Atp-dependent helicase
VagVIO5_24300	COG1489	DNA binding
VagVIO5_24320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VagVIO5_24340	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VagVIO5_24350	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VagVIO5_24360	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VagVIO5_24370	COG1560	Kdo2-lipid A biosynthetic process
VagVIO5_24380	COG0842	Transport permease protein
VagVIO5_24390	COG1131	(ABC) transporter
VagVIO5_24400	COG0659	secondary active sulfate transmembrane transporter activity
VagVIO5_24410	COG0288	reversible hydration of carbon dioxide
VagVIO5_24440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VagVIO5_24450	COG0508	dehydrogenase complex catalyzes the overall conversion of
VagVIO5_24460	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VagVIO5_24470	COG2186	Transcriptional regulator
VagVIO5_24490	COG0157	Belongs to the NadC ModD family
VagVIO5_24510	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VagVIO5_24520	COG1459	type II secretion system
VagVIO5_24540	COG0237	dephospho-CoA kinase activity
VagVIO5_24550	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VagVIO5_24560	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VagVIO5_24590	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VagVIO5_24600	COG0228	four-way junction DNA binding
VagVIO5_24610	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VagVIO5_24620	COG4137	Cytochrome C assembly protein
VagVIO5_24630	COG4536	flavin adenine dinucleotide binding
VagVIO5_24640	COG1854	S-ribosylhomocysteine lyase activity
VagVIO5_24670	COG0612	Peptidase, M16
VagVIO5_24680	COG1238	metal cluster binding
VagVIO5_24700	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VagVIO5_24710	COG5016	pyruvate
VagVIO5_24710	COG0511	ligase activity, forming carbon-carbon bonds
VagVIO5_24720	COG3630	sodium ion export across plasma membrane
VagVIO5_24740	COG0527	aspartate kinase activity
VagVIO5_24750	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VagVIO5_24760	COG2137	regulation of response to DNA damage stimulus
VagVIO5_24770	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VagVIO5_24780	COG1546	Belongs to the CinA family
VagVIO5_24790	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VagVIO5_24800	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VagVIO5_24820	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VagVIO5_24830	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VagVIO5_24850	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VagVIO5_24860	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VagVIO5_24870	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VagVIO5_24880	COG0148	phosphopyruvate hydratase activity
VagVIO5_24890	COG0504	CTP synthase activity
VagVIO5_24900	COG3956	TIGRFAM MazG family protein
VagVIO5_24910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VagVIO5_24920	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VagVIO5_24940	COG0736	holo-[acyl-carrier-protein] synthase activity
VagVIO5_24950	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VagVIO5_24960	COG1381	Involved in DNA repair and RecF pathway recombination
VagVIO5_24970	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VagVIO5_24990	COG0681	Belongs to the peptidase S26 family
VagVIO5_25000	COG0481	GTPase activity
VagVIO5_25010	COG3086	response to oxidative stress
VagVIO5_25040	COG1595	DNA-templated transcription, initiation
VagVIO5_25050	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VagVIO5_25070	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VagVIO5_25080	COG0354	folic acid binding
VagVIO5_25110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VagVIO5_25120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VagVIO5_25130	COG3079	Belongs to the UPF0149 family
VagVIO5_25140	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VagVIO5_25150	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VagVIO5_25160	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VagVIO5_25170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VagVIO5_25190	COG0583	DNA-binding transcription factor activity
VagVIO5_25220	COG0668	transmembrane transport
VagVIO5_25230	COG0191	fructose-bisphosphate aldolase activity
VagVIO5_25240	COG0126	phosphoglycerate kinase activity
VagVIO5_25250	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VagVIO5_25260	COG4771	TonB-dependent receptor
VagVIO5_25270	COG0583	DNA-binding transcription factor activity
VagVIO5_25280	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VagVIO5_25290	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VagVIO5_25320	COG2356	endonuclease I
VagVIO5_25330	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VagVIO5_25340	COG0189	ligase activity
VagVIO5_25350	COG1678	Uncharacterized ACR, COG1678
VagVIO5_25360	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VagVIO5_25390	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VagVIO5_25400	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VagVIO5_25410	COG0762	integral membrane protein
VagVIO5_25420	COG1872	DUF167
VagVIO5_25440	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VagVIO5_25450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VagVIO5_25460	COG2066	Belongs to the glutaminase family
VagVIO5_25480	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VagVIO5_25500	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VagVIO5_25540	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VagVIO5_25560	COG3394	polysaccharide catabolic process
VagVIO5_25570	COG1486	melibiose metabolic process
VagVIO5_25580	COG1447	Phosphotransferase system cellobiose-specific component IIA
VagVIO5_25590	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VagVIO5_25600	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VagVIO5_25610	COG0726	polysaccharide deacetylase
VagVIO5_25620	COG3706	GGDEF domain
VagVIO5_25630	COG3547	Transposase (IS116 IS110 IS902 family)
VagVIO5_25640	COG3547	Transposase (IS116 IS110 IS902 family)
VagVIO5_25920	COG1028	Short-chain dehydrogenase reductase Sdr
VagVIO5_25950	COG0795	lipopolysaccharide-transporting ATPase activity
VagVIO5_25960	COG0795	lipopolysaccharide-transporting ATPase activity
VagVIO5_25980	COG2927	DNA polymerase III (CHI subunit)
VagVIO5_25990	COG0525	valine-tRNA ligase activity
VagVIO5_26070	COG0540	Belongs to the ATCase OTCase family
VagVIO5_26080	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VagVIO5_26090	COG0251	oxidation-reduction process
VagVIO5_26100	COG0204	Acyl-transferase
VagVIO5_26120	COG5007	Belongs to the BolA IbaG family
VagVIO5_26140	COG2854	intermembrane phospholipid transfer
VagVIO5_26150	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VagVIO5_26160	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VagVIO5_26170	COG1127	ABC transporter
VagVIO5_26190	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VagVIO5_26190	COG0517	IMP dehydrogenase activity
VagVIO5_26210	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VagVIO5_26220	COG1137	ATPase activity
VagVIO5_26240	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VagVIO5_26250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VagVIO5_26260	COG1660	Displays ATPase and GTPase activities
VagVIO5_26270	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VagVIO5_26280	COG2239	Acts as a magnesium transporter
VagVIO5_26290	COG0312	modulator of DNA gyrase
VagVIO5_26300	COG3028	Belongs to the UPF0307 family
VagVIO5_26310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VagVIO5_26320	COG0564	pseudouridine synthase activity
VagVIO5_26340	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VagVIO5_26350	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VagVIO5_26360	COG0312	modulator of DNA gyrase
VagVIO5_26370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VagVIO5_26380	COG3164	Protein of unknown function
VagVIO5_26390	COG1530	ribonuclease E activity
VagVIO5_26400	COG0424	maF-like protein
VagVIO5_26410	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VagVIO5_26420	COG1792	Involved in formation and maintenance of cell shape
VagVIO5_26430	COG1077	Cell shape determining protein MreB Mrl
VagVIO5_26520	COG1459	type II secretion system
VagVIO5_26530	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VagVIO5_26550	COG3267	Type II secretory pathway component ExeA
VagVIO5_26550	COG3409	Peptidoglycan-binding domain 1 protein
VagVIO5_26560	COG1450	Type ii and iii secretion system protein
VagVIO5_26600	COG2200	EAL domain
VagVIO5_26600	COG2199	diguanylate cyclase activity
VagVIO5_26620	COG0629	single-stranded DNA binding
VagVIO5_26650	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VagVIO5_26670	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VagVIO5_26680	COG0527	aspartate kinase activity
VagVIO5_26690	COG0646	methionine synthase
VagVIO5_26690	COG1410	methionine synthase
VagVIO5_26730	COG0175	sulfate reduction
VagVIO5_26740	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VagVIO5_26750	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VagVIO5_26790	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VagVIO5_26840	COG0247	lactate metabolic process
VagVIO5_26850	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
VagVIO5_26860	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VagVIO5_27000	COG0735	belongs to the Fur family
VagVIO5_27020	COG0166	Belongs to the GPI family
VagVIO5_27040	COG0432	Pfam Uncharacterised protein family UPF0047
VagVIO5_27050	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VagVIO5_27100	COG2965	DNA replication, synthesis of RNA primer
VagVIO5_27110	COG0360	Binds together with S18 to 16S ribosomal RNA
VagVIO5_27120	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VagVIO5_27130	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VagVIO5_27150	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VagVIO5_27160	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VagVIO5_27220	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VagVIO5_27240	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VagVIO5_27240	COG0678	peroxiredoxin activity
VagVIO5_27250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VagVIO5_27280	COG0165	Argininosuccinate lyase
VagVIO5_27280	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VagVIO5_27290	COG0137	argininosuccinate synthase activity
VagVIO5_27310	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VagVIO5_27330	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VagVIO5_27350	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VagVIO5_27360	COG0460	homoserine dehydrogenase
VagVIO5_27360	COG0527	aspartate kinase activity
VagVIO5_27370	COG0626	cystathionine gamma-synthase activity
VagVIO5_27390	COG0281	malic enzyme
VagVIO5_27410	COG2906	2 iron, 2 sulfur cluster binding
VagVIO5_27420	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VagVIO5_27430	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VagVIO5_27470	COG2923	Belongs to the DsrF TusC family
VagVIO5_27480	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VagVIO5_27490	COG2964	Protein conserved in bacteria
VagVIO5_27500	COG0545	Peptidyl-prolyl cis-trans isomerase
VagVIO5_27530	COG1446	asparaginase
VagVIO5_27540	COG1047	Peptidyl-prolyl cis-trans
VagVIO5_27570	COG2249	NAD(P)H dehydrogenase (quinone) activity
VagVIO5_27580	COG0488	(ABC) transporter
VagVIO5_27600	COG0429	hydrolase of the alpha beta-hydrolase fold
VagVIO5_27610	COG3089	Belongs to the UPF0270 family
VagVIO5_27620	COG3954	Phosphoribulokinase
VagVIO5_27630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VagVIO5_27670	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VagVIO5_27680	COG0512	Glutamine amidotransferase of anthranilate synthase
VagVIO5_27710	COG0180	Tryptophanyl-tRNA synthetase
VagVIO5_27720	COG0546	phosphoglycolate phosphatase activity
VagVIO5_27730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VagVIO5_27740	COG0557	exoribonuclease II activity
VagVIO5_27750	COG1959	2 iron, 2 sulfur cluster binding
VagVIO5_27760	COG1017	nitric oxide dioxygenase activity
VagVIO5_27760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VagVIO5_27770	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VagVIO5_27780	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VagVIO5_27790	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VagVIO5_27800	COG0330	HflC and HflK could
VagVIO5_27810	COG0330	HflC and HflK could
VagVIO5_27820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VagVIO5_27840	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VagVIO5_27850	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VagVIO5_27870	COG0802	atpase or kinase
VagVIO5_27880	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VagVIO5_27890	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VagVIO5_27900	COG1162	GTPase activity
VagVIO5_27910	COG0688	phosphatidylethanolamine metabolic process
VagVIO5_27920	COG0471	metal ion transport
VagVIO5_27920	COG3273	potassium ion transport
VagVIO5_27940	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VagVIO5_27950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VagVIO5_27960	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VagVIO5_27970	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VagVIO5_27980	COG1045	serine acetyltransferase
VagVIO5_27990	COG4942	peptidase
VagVIO5_28030	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VagVIO5_28040	COG1053	succinate dehydrogenase
VagVIO5_28050	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VagVIO5_28060	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VagVIO5_28100	COG1509	lysine 2,3-aminomutase activity
VagVIO5_28110	COG1285	pathogenesis
VagVIO5_28130	COG0459	protein refolding
VagVIO5_28150	COG0534	Mate efflux family protein
VagVIO5_28160	COG0205	6-phosphofructokinase activity
VagVIO5_28170	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VagVIO5_28190	COG0745	RESPONSE REGULATOR receiver
VagVIO5_28200	COG2205	protein histidine kinase activity
VagVIO5_28220	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VagVIO5_28230	COG3030	protein affecting phage T7 exclusion by the F plasmid
VagVIO5_28240	COG1027	Aspartate ammonia-lyase
VagVIO5_28250	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VagVIO5_28260	COG4232	protein-disulfide reductase activity
VagVIO5_28280	COG3263	regulation of cellular component size
VagVIO5_28300	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VagVIO5_28350	COG2814	Major facilitator Superfamily
VagVIO5_28380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VagVIO5_28390	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VagVIO5_28400	COG0511	ligase activity, forming carbon-carbon bonds
VagVIO5_28410	COG0439	Biotin carboxylase
VagVIO5_28420	COG2264	protein methyltransferase activity
VagVIO5_28430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VagVIO5_28440	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VagVIO5_28460	COG0488	(ABC) transporter
VagVIO5_28470	COG1982	Orn Lys Arg decarboxylase major
VagVIO5_28480	COG0531	amino acid
VagVIO5_28500	COG3710	Transcriptional regulator
VagVIO5_28510	COG0789	Transcriptional regulator
VagVIO5_28520	COG0138	bifunctional purine biosynthesis protein purh
VagVIO5_28530	COG0151	Belongs to the GarS family
VagVIO5_28560	COG1253	flavin adenine dinucleotide binding
VagVIO5_28570	COG3068	Protein conserved in bacteria
VagVIO5_28590	COG1573	uracil-dna glycosylase
VagVIO5_28600	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VagVIO5_28610	COG2816	NAD+ diphosphatase activity
VagVIO5_28620	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VagVIO5_28630	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VagVIO5_28640	COG0085	RNA polymerase activity
VagVIO5_28650	COG0222	ribosome binding
VagVIO5_28660	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VagVIO5_28690	COG0250	Participates in transcription elongation, termination and antitermination
VagVIO5_28700	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VagVIO5_28710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VagVIO5_28730	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
VagVIO5_28730	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
VagVIO5_28740	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VagVIO5_28760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VagVIO5_28800	COG4206	TonB-dependent receptor
VagVIO5_28840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VagVIO5_28850	COG0534	Mate efflux family protein
VagVIO5_28860	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
VagVIO5_28870	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VagVIO5_28880	COG2937	Belongs to the GPAT DAPAT family
VagVIO5_28890	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VagVIO5_28900	COG3161	chorismate lyase activity
VagVIO5_28910	COG1580	Controls the rotational direction of flagella during chemotaxis
VagVIO5_28920	COG0705	Rhomboid family
VagVIO5_28930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VagVIO5_28950	COG2177	Part of the ABC transporter FtsEX involved in
VagVIO5_28960	COG2884	Cell division ATP-binding protein ftsE
VagVIO5_28970	COG0552	protein localization to endoplasmic reticulum
VagVIO5_28980	COG0742	ribosomal rna small subunit methyltransferase
VagVIO5_29000	COG2095	MarC family integral membrane protein
VagVIO5_29090	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VagVIO5_29100	COG0640	Transcriptional regulator
VagVIO5_29110	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VagVIO5_29120	COG1280	lysine exporter protein (LysE YggA)
VagVIO5_29130	COG2267	carboxylic ester hydrolase activity
VagVIO5_29140	COG0561	phosphatase activity
VagVIO5_29180	COG2199	diguanylate cyclase activity
VagVIO5_29180	COG3287	FIST C domain
VagVIO5_29180	COG2200	EAL domain
VagVIO5_29190	COG1011	Hydrolase
VagVIO5_29200	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VagVIO5_29220	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VagVIO5_29230	COG0019	diaminopimelate decarboxylase activity
VagVIO5_29240	COG1965	Belongs to the frataxin family
VagVIO5_29260	COG3072	Adenylate cyclase
VagVIO5_29270	COG0181	hydroxymethylbilane synthase activity
VagVIO5_29280	COG1587	Uroporphyrinogen-III synthase
VagVIO5_29290	COG2959	enzyme of heme biosynthesis
VagVIO5_29300	COG3071	HemY protein
VagVIO5_29320	COG0633	Ferredoxin
VagVIO5_29330	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VagVIO5_29360	COG3118	belongs to the thioredoxin family
VagVIO5_29370	COG0513	Belongs to the DEAD box helicase family
VagVIO5_29380	COG0248	Ppx GppA phosphatase
VagVIO5_29390	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VagVIO5_29410	COG0514	ATP-dependent DNA helicase (RecQ)
VagVIO5_29420	COG2962	Rard protein
VagVIO5_29440	COG1280	lysine exporter protein (LysE YggA)
VagVIO5_29450	COG0405	Gamma-glutamyltransferase
VagVIO5_29470	COG0210	DNA helicase
VagVIO5_29490	COG3220	belongs to the UPF0276 family
VagVIO5_29550	COG0006	proline dipeptidase activity
VagVIO5_29550	COG0006	proline dipeptidase activity
VagVIO5_29590	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VagVIO5_29620	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VagVIO5_29630	COG2132	Multicopper oxidase
VagVIO5_29640	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VagVIO5_29660	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VagVIO5_29670	COG0408	coproporphyrinogen oxidase activity
VagVIO5_29680	COG0009	L-threonylcarbamoyladenylate synthase
VagVIO5_29690	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VagVIO5_29700	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VagVIO5_29710	COG0551	DNA topoisomerase type I activity
VagVIO5_29720	COG2922	Belongs to the Smg family
VagVIO5_29730	COG0758	DNA mediated transformation
VagVIO5_29750	COG0242	peptide deformylase activity
VagVIO5_29760	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VagVIO5_29770	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VagVIO5_29770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VagVIO5_29780	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VagVIO5_29780	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VagVIO5_29790	COG0569	domain protein
VagVIO5_29800	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VagVIO5_29820	COG1272	protein, Hemolysin III
VagVIO5_29830	COG4326	sporulation control protein
VagVIO5_29850	COG3084	Protein conserved in bacteria
VagVIO5_29870	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VagVIO5_29880	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VagVIO5_29890	COG0204	Acyl-transferase
VagVIO5_29910	COG0606	chelatase, subunit chli
VagVIO5_29930	COG3978	acetolactate synthase activity
VagVIO5_29940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VagVIO5_29950	COG0129	dihydroxy-acid dehydratase activity
VagVIO5_29970	COG0583	DNA-binding transcription factor activity
VagVIO5_29980	COG2814	Major facilitator Superfamily
VagVIO5_30000	COG0765	amino acid transport
VagVIO5_30020	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VagVIO5_30030	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VagVIO5_30040	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VagVIO5_30050	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VagVIO5_30060	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VagVIO5_30070	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VagVIO5_30090	COG0356	it plays a direct role in the translocation of protons across the membrane
VagVIO5_30100	COG3312	ion transport
VagVIO5_30110	COG1475	DNA binding
VagVIO5_30120	COG1192	Involved in chromosome partitioning
VagVIO5_30130	COG0357	Ribosomal RNA small subunit methyltransferase G
VagVIO5_30140	COG0445	tRNA wobble uridine modification
VagVIO5_30150	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VagVIO5_30170	COG3706	GGDEF domain
VagVIO5_30200	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VagVIO5_30210	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VagVIO5_30230	COG1609	Transcriptional regulator
VagVIO5_30440	COG4974	Belongs to the 'phage' integrase family
VagVIO5_30460	COG0706	membrane insertase activity
VagVIO5_30470	COG0594	ribonuclease P activity
VagVIO5_30490	COG1126	abc transporter atp-binding protein
VagVIO5_30540	COG4608	Belongs to the ABC transporter superfamily
VagVIO5_30550	COG0444	Belongs to the ABC transporter superfamily
VagVIO5_30570	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
VagVIO5_30570	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VagVIO5_30620	COG0772	Belongs to the SEDS family
VagVIO5_30640	COG1136	(ABC) transporter
VagVIO5_30680	COG3275	phosphorelay sensor kinase activity
VagVIO5_30690	COG3279	Response regulator of the LytR AlgR family
VagVIO5_30710	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VagVIO5_30750	COG0786	glutamate:sodium symporter activity
VagVIO5_30770	COG1131	(ABC) transporter
VagVIO5_30780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VagVIO5_30790	COG0786	glutamate:sodium symporter activity
VagVIO5_30810	COG0363	glucosamine-6-phosphate deaminase activity
VagVIO5_30850	COG1741	Belongs to the pirin family
VagVIO5_30860	COG2259	Doxx family
VagVIO5_30880	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
VagVIO5_30890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VagVIO5_30910	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VagVIO5_30970	COG0596	Alpha beta hydrolase
VagVIO5_31000	COG3123	guanosine phosphorylase activity
VagVIO5_31030	COG0534	Mate efflux family protein
VagVIO5_31040	COG0564	pseudouridine synthase activity
VagVIO5_31070	COG0583	DNA-binding transcription factor activity
VagVIO5_31080	COG0561	phosphatase activity
VagVIO5_31100	COG2199	diguanylate cyclase activity
VagVIO5_31130	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
VagVIO5_31140	COG2162	N-hydroxyarylamine O-acetyltransferase activity
VagVIO5_31150	COG0583	DNA-binding transcription factor activity
VagVIO5_31230	COG1357	PFAM Pentapeptide repeats (8 copies)
VagVIO5_31240	COG3047	cAMP biosynthetic process
VagVIO5_31300	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
VagVIO5_31300	COG3408	Glycogen debranching enzyme
VagVIO5_31310	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
VagVIO5_31350	COG0583	DNA-binding transcription factor activity
VagVIO5_31380	COG0546	phosphoglycolate phosphatase activity
VagVIO5_31430	COG3835	regulator
VagVIO5_31440	COG2610	gluconate transmembrane transporter activity
VagVIO5_31450	COG1929	Belongs to the glycerate kinase type-1 family
VagVIO5_31460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VagVIO5_31500	COG0456	acetyltransferase
VagVIO5_31530	COG1028	Short-chain dehydrogenase reductase Sdr
VagVIO5_31540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VagVIO5_31550	COG3005	denitrification pathway
VagVIO5_31560	COG0243	molybdopterin cofactor binding
VagVIO5_31580	COG0352	thiamine-phosphate diphosphorylase activity
VagVIO5_31590	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
VagVIO5_31600	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
VagVIO5_31610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VagVIO5_31620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VagVIO5_31630	COG1116	anion transmembrane transporter activity
VagVIO5_31640	COG0351	phosphomethylpyrimidine kinase
VagVIO5_31650	COG0312	modulator of DNA gyrase
VagVIO5_31660	COG0312	modulator of DNA gyrase
VagVIO5_31670	COG1901	pseudouridine methyltransferase
VagVIO5_31720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VagVIO5_31740	COG0584	glycerophosphoryl diester phosphodiesterase
VagVIO5_31750	COG0039	L-malate dehydrogenase activity
VagVIO5_31760	COG0745	RESPONSE REGULATOR receiver
VagVIO5_31800	COG0811	peptide transport
VagVIO5_31810	COG0811	peptide transport
VagVIO5_31820	COG0848	biopolymer transport protein
VagVIO5_31910	COG0803	Belongs to the bacterial solute-binding protein 9 family
VagVIO5_31920	COG1121	(ABC) transporter
VagVIO5_31930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VagVIO5_31960	COG1770	oligopeptidase
VagVIO5_31970	COG2814	Major facilitator Superfamily
VagVIO5_31980	COG0010	Belongs to the arginase family
VagVIO5_31990	COG1166	arginine decarboxylase activity
VagVIO5_32010	COG0189	ligase activity
VagVIO5_32010	COG4067	protein conserved in archaea
VagVIO5_32020	COG0189	ligase activity
VagVIO5_32030	COG0583	DNA-binding transcription factor activity
VagVIO5_32100	COG4191	Histidine kinase
VagVIO5_32110	COG2204	response regulator
VagVIO5_32120	COG3706	GGDEF domain
VagVIO5_32160	COG0579	oxidoreductase
VagVIO5_32180	COG1294	oxidase, subunit
VagVIO5_32190	COG1271	oxidase subunit
VagVIO5_32210	COG3033	Beta-eliminating lyase
VagVIO5_32230	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VagVIO5_32260	COG3706	GGDEF domain
VagVIO5_32290	COG3706	GGDEF domain
VagVIO5_32300	COG0415	Belongs to the DNA photolyase family
VagVIO5_32310	COG3046	protein related to deoxyribodipyrimidine photolyase
VagVIO5_32330	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VagVIO5_32330	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VagVIO5_32340	COG1765	OsmC-like protein
VagVIO5_32350	COG0110	maltose O-acetyltransferase activity
VagVIO5_32430	COG1011	Hydrolase
VagVIO5_32460	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VagVIO5_32470	COG3338	carbonate dehydratase activity
VagVIO5_32480	COG2067	long-chain fatty acid transport protein
VagVIO5_32490	COG3240	lipase activity
VagVIO5_32550	COG1609	Transcriptional regulator
VagVIO5_32560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VagVIO5_32590	COG1840	ABC-type Fe3 transport system, periplasmic component
VagVIO5_32600	COG3842	ATPase activity
VagVIO5_32650	COG2990	Protein conserved in bacteria
VagVIO5_32670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VagVIO5_32680	COG2866	Carboxypeptidase
VagVIO5_32700	COG0583	DNA-binding transcription factor activity
VagVIO5_32740	COG3104	oligopeptide transport
VagVIO5_32750	COG1760	l-serine dehydratase
VagVIO5_32790	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VagVIO5_32800	COG0741	lytic transglycosylase activity
VagVIO5_32840	COG1815	bacterial-type flagellum-dependent cell motility
VagVIO5_32850	COG1558	bacterial-type flagellum-dependent cell motility
VagVIO5_32860	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
VagVIO5_32870	COG1749	Flagellar hook protein flgE
VagVIO5_32880	COG4787	bacterial-type flagellum-dependent cell motility
VagVIO5_32890	COG4786	Flagellar basal body rod
VagVIO5_32900	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VagVIO5_32910	COG1706	bacterial-type flagellum-dependent cell motility
VagVIO5_32930	COG1256	bacterial-type flagellum assembly
VagVIO5_32930	COG4786	Flagellar basal body rod
VagVIO5_32940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VagVIO5_32980	COG1304	FMN binding
VagVIO5_33010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VagVIO5_33020	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VagVIO5_33030	COG0459	protein refolding
VagVIO5_33060	COG1280	lysine exporter protein (LysE YggA)
VagVIO5_33100	COG1309	transcriptional regulator
VagVIO5_33120	COG4303	Ethanolamine ammonia lyase large subunit
VagVIO5_33130	COG4302	ethanolamine ammonia-lyase activity
VagVIO5_33140	COG0531	amino acid
VagVIO5_33150	COG2070	2-Nitropropane dioxygenase
VagVIO5_33160	COG3537	Alpha-1,2-mannosidase
VagVIO5_33170	COG3537	Alpha-1,2-mannosidase
VagVIO5_33190	COG3537	Alpha-1,2-mannosidase
VagVIO5_33200	COG3537	Alpha-1,2-mannosidase
VagVIO5_33210	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VagVIO5_33230	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VagVIO5_33230	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VagVIO5_33240	COG0346	lactoylglutathione lyase activity
VagVIO5_33250	COG1349	DNA-binding transcription factor activity
VagVIO5_33270	COG1335	isochorismatase
VagVIO5_33290	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
VagVIO5_33340	COG0583	DNA-binding transcription factor activity
VagVIO5_33370	COG3713	MltA-interacting MipA family protein
VagVIO5_33380	COG3015	lipoprotein NlpE involved in copper resistance
VagVIO5_33390	COG3448	diguanylate cyclase activity
VagVIO5_33390	COG4175	Glycine betaine
VagVIO5_33400	COG4176	ABC-type proline glycine betaine transport system permease component
VagVIO5_33410	COG1342	Belongs to the UPF0251 family
VagVIO5_33470	COG4948	Mandelate Racemase Muconate Lactonizing
VagVIO5_33490	COG0583	DNA-binding transcription factor activity
VagVIO5_33560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VagVIO5_33630	COG3842	ATPase activity
VagVIO5_33690	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VagVIO5_33750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VagVIO5_33780	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VagVIO5_33790	COG2197	response regulator
VagVIO5_33820	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
VagVIO5_33830	COG0252	asparaginase activity
VagVIO5_33850	COG0583	DNA-binding transcription factor activity
VagVIO5_33870	COG1280	lysine exporter protein (LysE YggA)
VagVIO5_33880	COG3122	Protein conserved in bacteria
VagVIO5_33900	COG2423	ornithine cyclodeaminase activity
VagVIO5_33910	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
VagVIO5_33920	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VagVIO5_33930	COG1012	belongs to the aldehyde dehydrogenase family
VagVIO5_33940	COG1522	sequence-specific DNA binding
VagVIO5_33950	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VagVIO5_33960	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VagVIO5_33970	COG3608	succinylglutamate desuccinylase aspartoacylase
VagVIO5_33980	COG0006	proline dipeptidase activity
VagVIO5_33990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VagVIO5_34000	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VagVIO5_34010	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VagVIO5_34020	COG2207	Transcriptional regulator
VagVIO5_34030	COG1028	Short-chain dehydrogenase reductase Sdr
VagVIO5_34050	COG1063	alcohol dehydrogenase
VagVIO5_34060	COG1902	pentaerythritol trinitrate reductase activity
VagVIO5_34090	COG0583	DNA-binding transcription factor activity
VagVIO5_34110	COG0513	Belongs to the DEAD box helicase family
VagVIO5_34150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VagVIO5_34160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VagVIO5_34160	COG2207	Transcriptional regulator
VagVIO5_34210	COG3746	phosphate-selective porin O and P
VagVIO5_34240	COG1028	Short-chain dehydrogenase reductase Sdr
VagVIO5_34300	COG1263	PTS System
VagVIO5_34300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VagVIO5_34310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VagVIO5_34320	COG1621	beta-fructofuranosidase activity
VagVIO5_34330	COG0625	glutathione transferase activity
VagVIO5_34350	COG1686	Belongs to the peptidase S11 family
VagVIO5_34380	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VagVIO5_34380	COG0678	peroxiredoxin activity
VagVIO5_34390	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VagVIO5_34400	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VagVIO5_34430	COG1278	Cold shock
VagVIO5_34440	COG1741	Belongs to the pirin family
VagVIO5_34450	COG4667	esterase of the alpha-beta hydrolase superfamily
VagVIO5_34500	COG2194	sulfuric ester hydrolase activity
VagVIO5_34510	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VagVIO5_34530	COG2205	protein histidine kinase activity
VagVIO5_34540	COG0745	RESPONSE REGULATOR receiver
VagVIO5_34570	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VagVIO5_34610	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VagVIO5_34630	COG2814	Major facilitator Superfamily
VagVIO5_34650	COG1418	mRNA catabolic process
VagVIO5_34660	COG0402	S-adenosylhomocysteine deaminase activity
VagVIO5_34670	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
VagVIO5_34680	COG2239	Acts as a magnesium transporter
VagVIO5_34690	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VagVIO5_34700	COG1566	PFAM secretion protein HlyD family protein
VagVIO5_34750	COG0745	RESPONSE REGULATOR receiver
VagVIO5_34760	COG2205	protein histidine kinase activity
VagVIO5_34790	COG0531	amino acid
VagVIO5_34810	COG0583	DNA-binding transcription factor activity
VagVIO5_34860	COG0784	Response regulator, receiver
VagVIO5_34860	COG2205	protein histidine kinase activity
VagVIO5_34860	COG5002	protein histidine kinase activity
VagVIO5_34870	COG0534	Mate efflux family protein
VagVIO5_34900	COG3132	Protein of unknown function, DUF480
VagVIO5_34910	COG2827	Endonuclease containing a URI domain
VagVIO5_34920	COG1879	ABC-type sugar transport system periplasmic component
VagVIO5_34930	COG2205	protein histidine kinase activity
VagVIO5_34930	COG0784	Response regulator, receiver
VagVIO5_35040	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VagVIO5_35050	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VagVIO5_35070	COG1280	lysine exporter protein (LysE YggA)
VagVIO5_35090	COG0183	Belongs to the thiolase family
VagVIO5_35110	COG3243	poly(R)-hydroxyalkanoic acid synthase
VagVIO5_35130	COG3005	denitrification pathway
VagVIO5_35150	COG0243	molybdopterin cofactor binding
VagVIO5_35170	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VagVIO5_35180	COG3850	Histidine kinase
VagVIO5_35190	COG2197	response regulator
VagVIO5_35220	COG2195	Cleaves the N-terminal amino acid of tripeptides
VagVIO5_35260	COG0840	transmembrane signaling receptor activity
VagVIO5_35280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VagVIO5_35300	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VagVIO5_35310	COG2814	Major facilitator Superfamily
VagVIO5_35320	COG0840	transmembrane signaling receptor activity
VagVIO5_35330	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VagVIO5_35340	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VagVIO5_35380	COG2897	thiosulfate sulfurtransferase activity
VagVIO5_35420	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VagVIO5_35450	COG1914	H( )-stimulated, divalent metal cation uptake system
VagVIO5_35470	COG0038	chloride channel
VagVIO5_35500	COG4989	oxidoreductase activity
VagVIO5_35530	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
VagVIO5_35530	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
VagVIO5_35550	COG1013	pyruvate-flavodoxin oxidoreductase activity
VagVIO5_35560	COG0674	pyruvate-flavodoxin oxidoreductase activity
VagVIO5_35560	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
VagVIO5_35580	COG0739	heme binding
VagVIO5_35670	COG3501	Rhs element vgr protein
VagVIO5_35720	COG0515	serine threonine protein kinase
VagVIO5_35790	COG1522	sequence-specific DNA binding
VagVIO5_35930	COG2814	Major facilitator Superfamily
VagVIO5_35950	COG0583	DNA-binding transcription factor activity
VagVIO5_35960	COG4221	oxidoreductase activity
VagVIO5_35970	COG0589	response to stress
VagVIO5_35990	COG2111	Na H antiporter
VagVIO5_35990	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VagVIO5_36030	COG2212	antiporter activity
VagVIO5_36040	COG1320	monovalent cation:proton antiporter activity
VagVIO5_36050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VagVIO5_36180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VagVIO5_36210	COG3527	Alpha-acetolactate decarboxylase
VagVIO5_36270	COG0384	phenazine biosynthesis protein PhzF
VagVIO5_36290	COG1294	oxidase, subunit
VagVIO5_36300	COG1271	oxidase subunit
VagVIO5_36310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VagVIO5_36350	COG3437	response regulator, receiver
VagVIO5_36350	COG4999	Histidine kinase
VagVIO5_36350	COG2205	protein histidine kinase activity
VagVIO5_36350	COG3850	Histidine kinase
VagVIO5_36370	COG4770	biotin carboxylase activity
VagVIO5_36390	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VagVIO5_36400	COG1960	acyl-CoA dehydrogenase activity
VagVIO5_36420	COG0183	Belongs to the thiolase family
VagVIO5_36440	COG1960	acyl-CoA dehydrogenase activity
VagVIO5_36450	COG1024	Enoyl-CoA hydratase
VagVIO5_36480	COG1028	Short-chain dehydrogenase reductase Sdr
VagVIO5_36500	COG1309	transcriptional regulator
VagVIO5_36510	COG1012	belongs to the aldehyde dehydrogenase family
VagVIO5_36540	COG4176	ABC-type proline glycine betaine transport system permease component
VagVIO5_36550	COG4175	Glycine betaine
VagVIO5_36550	COG0517	IMP dehydrogenase activity
VagVIO5_36580	COG0330	HflC and HflK could
VagVIO5_36610	COG5001	Diguanylate cyclase
VagVIO5_36610	COG3300	MHYT domain
VagVIO5_36640	COG0784	Response regulator, receiver
VagVIO5_36640	COG2205	protein histidine kinase activity
VagVIO5_36660	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
VagVIO5_36750	COG5001	Diguanylate cyclase
VagVIO5_36760	COG1869	D-ribose catabolic process
VagVIO5_36770	COG1129	ABC transporter
VagVIO5_36780	COG1172	Belongs to the binding-protein-dependent transport system permease family
VagVIO5_36790	COG1879	ABC-type sugar transport system periplasmic component
VagVIO5_36800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VagVIO5_36810	COG1609	Transcriptional regulator
VagVIO5_36840	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VagVIO5_36860	COG4607	ABC-type enterochelin transport system periplasmic component
VagVIO5_36870	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VagVIO5_36880	COG4605	iron ion homeostasis
VagVIO5_36890	COG4604	ABC transporter, ATP-binding protein
VagVIO5_36900	COG0789	Transcriptional regulator
VagVIO5_36910	COG2207	Transcriptional regulator
VagVIO5_36920	COG4771	TonB-dependent receptor
VagVIO5_36920	COG1629	transport
VagVIO5_36980	COG1289	transmembrane transporter activity
VagVIO5_36990	COG0210	DNA helicase
VagVIO5_37000	COG1803	Methylglyoxal synthase
VagVIO5_37010	COG1879	ABC-type sugar transport system periplasmic component
VagVIO5_37020	COG2198	Histidine kinase
VagVIO5_37020	COG0784	Response regulator, receiver
VagVIO5_37020	COG2205	protein histidine kinase activity
VagVIO5_37060	COG3119	arylsulfatase activity
VagVIO5_37080	COG3119	arylsulfatase activity
VagVIO5_37090	COG0641	radical SAM
VagVIO5_37100	COG0714	Associated with various cellular activities
VagVIO5_37160	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VagVIO5_37160	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VagVIO5_37170	COG0583	DNA-binding transcription factor activity
VagVIO5_37180	COG1597	lipid kinase activity
VagVIO5_37190	COG3111	PFAM Bacterial OB fold (BOF) protein
VagVIO5_37250	COG0501	Belongs to the peptidase M48B family
VagVIO5_37260	COG1704	LemA family
VagVIO5_37270	COG3069	C4-dicarboxylate transmembrane transporter activity
VagVIO5_37290	COG1214	PFAM Peptidase M22, glycoprotease
VagVIO5_37290	COG0456	acetyltransferase
VagVIO5_37330	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
VagVIO5_37350	COG3706	GGDEF domain
VagVIO5_37370	COG2197	response regulator
VagVIO5_37380	COG0784	Response regulator, receiver
VagVIO5_37380	COG0835	chemotaxis
VagVIO5_37410	COG2962	Rard protein
VagVIO5_37510	COG0471	metal ion transport
VagVIO5_37520	COG3290	protein histidine kinase activity
VagVIO5_37530	COG4565	transcriptional regulatory protein
VagVIO5_37560	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
VagVIO5_37570	COG5642	Protein of unknown function (DUF2384)
VagVIO5_37590	COG2755	lipolytic protein G-D-S-L family
VagVIO5_37590	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
VagVIO5_37610	COG1902	pentaerythritol trinitrate reductase activity
VagVIO5_37620	COG0346	lactoylglutathione lyase activity
VagVIO5_37660	COG2239	Acts as a magnesium transporter
VagVIO5_37700	COG0242	peptide deformylase activity
VagVIO5_37780	COG2176	DNA-directed DNA polymerase activity
VagVIO5_37840	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VagVIO5_37850	COG0346	lactoylglutathione lyase activity
VagVIO5_37920	COG1979	alcohol dehydrogenase
VagVIO5_37930	COG2207	Transcriptional regulator
VagVIO5_37950	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VagVIO5_37960	COG2759	Belongs to the formate--tetrahydrofolate ligase family
VagVIO5_37970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VagVIO5_38010	COG0546	phosphoglycolate phosphatase activity
VagVIO5_38020	COG0840	transmembrane signaling receptor activity
VagVIO5_38050	COG0513	Belongs to the DEAD box helicase family
VagVIO5_38060	COG4943	cyclic-guanylate-specific phosphodiesterase activity
VagVIO5_38090	COG3038	cytochrome b561
VagVIO5_38100	COG2353	YceI-like domain
VagVIO5_38110	COG2116	formate transmembrane transporter activity
VagVIO5_38120	COG0583	DNA-binding transcription factor activity
VagVIO5_38140	COG3593	DNA synthesis involved in DNA repair
VagVIO5_38150	COG0737	Belongs to the 5'-nucleotidase family
VagVIO5_38210	COG2267	carboxylic ester hydrolase activity
VagVIO5_38220	COG2067	long-chain fatty acid transport protein
VagVIO5_38250	COG2050	protein possibly involved in aromatic compounds catabolism
VagVIO5_38270	COG4533	DNA binding
VagVIO5_38340	COG5001	Diguanylate cyclase
VagVIO5_38340	COG1716	ATPase activity
VagVIO5_38350	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VagVIO5_38370	COG4181	ATPase activity
VagVIO5_38380	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
VagVIO5_38400	COG1984	allophanate hydrolase subunit 2
VagVIO5_38410	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
VagVIO5_38420	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VagVIO5_38430	COG5002	protein histidine kinase activity
VagVIO5_38430	COG5001	Diguanylate cyclase
VagVIO5_38430	COG3447	MASE1 domain protein
VagVIO5_38440	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VagVIO5_38460	COG0583	DNA-binding transcription factor activity
VagVIO5_38470	COG1042	CoA-binding domain protein
VagVIO5_38470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VagVIO5_38470	COG0045	succinate-CoA ligase (ADP-forming) activity
VagVIO5_38490	COG1181	Belongs to the D-alanine--D-alanine ligase family
VagVIO5_38510	COG0023	Translation Initiation Factor
VagVIO5_38530	COG4128	Pfam Zonular occludens toxin
VagVIO5_38630	COG4128	Pfam Zonular occludens toxin
VagVIO5_38750	COG0583	DNA-binding transcription factor activity
VagVIO5_38770	COG0589	response to stress
VagVIO5_38780	COG3140	Belongs to the UPF0181 family
VagVIO5_38830	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VagVIO5_38840	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VagVIO5_38890	COG5001	Diguanylate cyclase
VagVIO5_38890	COG2203	Gaf domain
VagVIO5_38890	COG3706	GGDEF domain
VagVIO5_38890	COG4251	negative regulation of phosphorylation
VagVIO5_38910	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
VagVIO5_38920	COG4149	molybdate abc transporter
VagVIO5_38930	COG0725	ABC transporter, periplasmic molybdate-binding protein
VagVIO5_38970	COG4067	protein conserved in archaea
VagVIO5_38970	COG0189	ligase activity
VagVIO5_38990	COG2207	Transcriptional regulator
VagVIO5_39000	COG0534	Mate efflux family protein
VagVIO5_39010	COG0602	queuosine metabolic process
VagVIO5_39020	COG1328	CTP reductase activity
VagVIO5_39050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VagVIO5_39110	COG1794	racemase activity, acting on amino acids and derivatives
VagVIO5_39120	COG0384	phenazine biosynthesis protein PhzF
VagVIO5_39140	COG0243	molybdopterin cofactor binding
VagVIO5_39150	COG0583	DNA-binding transcription factor activity
VagVIO5_39160	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VagVIO5_39180	COG2197	response regulator
VagVIO5_39190	COG3851	Histidine kinase
VagVIO5_39200	COG2271	Major facilitator Superfamily
VagVIO5_39250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VagVIO5_39260	COG3118	belongs to the thioredoxin family
VagVIO5_39330	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VagVIO5_39370	COG2116	formate transmembrane transporter activity
VagVIO5_39390	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VagVIO5_39400	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VagVIO5_39410	COG5001	Diguanylate cyclase
VagVIO5_39510	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VagVIO5_39580	COG0277	FAD linked oxidase domain protein
VagVIO5_39590	COG0583	DNA-binding transcription factor activity
VagVIO5_39600	COG2425	protein containing a von Willebrand factor type A (vWA) domain
VagVIO5_39630	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
VagVIO5_39650	COG1288	antiporter activity
VagVIO5_39670	COG3040	lipid binding
VagVIO5_39690	COG0419	ATPase involved in DNA repair
VagVIO5_39700	COG0420	3'-5' exonuclease activity
VagVIO5_39730	COG3501	Rhs element vgr protein
VagVIO5_39840	COG0631	protein serine/threonine phosphatase activity
VagVIO5_39910	COG0515	serine threonine protein kinase
VagVIO5_39910	COG2815	serine threonine protein kinase
VagVIO5_39950	COG0745	RESPONSE REGULATOR receiver
VagVIO5_39970	COG0625	glutathione transferase activity
VagVIO5_40010	COG2146	nitrite reductase [NAD(P)H] activity
VagVIO5_40010	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VagVIO5_40020	COG1116	anion transmembrane transporter activity
VagVIO5_40030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VagVIO5_40040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VagVIO5_40040	COG1116	anion transmembrane transporter activity
VagVIO5_40090	COG0243	molybdopterin cofactor binding
VagVIO5_40110	COG0814	amino acid
VagVIO5_40130	COG3706	GGDEF domain
VagVIO5_40230	COG2847	Copper chaperone PCu(A)C
VagVIO5_40240	COG0443	Heat shock 70 kDa protein
VagVIO5_40370	COG4160	amino acid transport
VagVIO5_40380	COG4215	(ABC) transporter
VagVIO5_40390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VagVIO5_40400	COG1126	abc transporter atp-binding protein
VagVIO5_40460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VagVIO5_40480	COG1012	belongs to the aldehyde dehydrogenase family
VagVIO5_40520	COG1902	pentaerythritol trinitrate reductase activity
VagVIO5_40520	COG0446	pyridine nucleotide-disulphide oxidoreductase
VagVIO5_40540	COG0109	protoheme IX farnesyltransferase activity
VagVIO5_40550	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
VagVIO5_40560	COG1845	cytochrome c oxidase, subunit III
VagVIO5_40570	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VagVIO5_40580	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VagVIO5_40590	COG1028	Short-chain dehydrogenase reductase Sdr
VagVIO5_40610	COG1024	Enoyl-CoA hydratase
VagVIO5_40620	COG1024	Enoyl-CoA hydratase
VagVIO5_40650	COG0183	Belongs to the thiolase family
VagVIO5_40670	COG1960	acyl-CoA dehydrogenase activity
VagVIO5_40680	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VagVIO5_40690	COG1024	Enoyl-CoA hydratase
VagVIO5_40710	COG5413	integral membrane protein
VagVIO5_40730	COG0247	lactate metabolic process
VagVIO5_40730	COG0277	FAD linked oxidase domain protein
VagVIO5_40840	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VagVIO5_40860	COG0513	Belongs to the DEAD box helicase family
VagVIO5_40870	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
VagVIO5_40920	COG0840	transmembrane signaling receptor activity
VagVIO5_40930	COG1119	ATPase activity
VagVIO5_40940	COG2200	EAL domain
VagVIO5_40990	COG0513	Belongs to the DEAD box helicase family
VagVIO5_41000	COG0523	cobalamin synthesis protein
VagVIO5_41020	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
VagVIO5_41040	COG1278	Cold shock
VagVIO5_41050	COG0557	exoribonuclease II activity
VagVIO5_41060	COG0133	tryptophan synthase activity
VagVIO5_41080	COG4628	conserved protein (DUF2132)
VagVIO5_41090	COG0513	Belongs to the DEAD box helicase family
VagVIO5_41110	COG0730	response to heat
VagVIO5_41140	COG0697	spore germination
VagVIO5_41150	COG1982	Orn Lys Arg decarboxylase major
VagVIO5_41160	COG1335	isochorismatase
VagVIO5_41180	COG1404	Belongs to the peptidase S8 family
VagVIO5_41210	COG3530	Putative quorum-sensing-regulated virulence factor
VagVIO5_41260	COG3186	Phenylalanine-4-hydroxylase
VagVIO5_41270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VagVIO5_41280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VagVIO5_41330	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
VagVIO5_41340	COG1454	alcohol dehydrogenase
VagVIO5_41350	COG2133	pyrroloquinoline quinone binding
VagVIO5_41370	COG0783	Belongs to the Dps family
VagVIO5_41380	COG0840	transmembrane signaling receptor activity
VagVIO5_41400	COG0577	efflux transmembrane transporter activity
VagVIO5_41400	COG1136	(ABC) transporter
VagVIO5_41440	COG2199	diguanylate cyclase activity
VagVIO5_41450	COG3036	rescue of stalled ribosome
VagVIO5_41460	COG1278	Cold shock
VagVIO5_41500	COG2885	chlorophyll binding
VagVIO5_41520	COG0545	Peptidyl-prolyl cis-trans isomerase
VagVIO5_41530	COG0109	protoheme IX farnesyltransferase activity
VagVIO5_41540	COG1612	heme a metabolic process
VagVIO5_41580	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
VagVIO5_41590	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VagVIO5_41600	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VagVIO5_41610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VagVIO5_41630	COG1280	lysine exporter protein (LysE YggA)
VagVIO5_41640	COG2207	Transcriptional regulator
VagVIO5_41670	COG0179	Fumarylacetoacetate (FAA) hydrolase
VagVIO5_41710	COG0697	spore germination
VagVIO5_41750	COG2814	Major facilitator Superfamily
VagVIO5_41760	COG0583	DNA-binding transcription factor activity
VagVIO5_41770	COG5001	Diguanylate cyclase
VagVIO5_41780	COG0739	heme binding
VagVIO5_41840	COG0840	transmembrane signaling receptor activity
VagVIO5_41860	COG0814	amino acid
VagVIO5_41890	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
VagVIO5_41900	COG1072	(Pantothenic acid kinase))
VagVIO5_41920	COG1063	alcohol dehydrogenase
VagVIO5_41930	COG2213	PTS system mannitol-specific
VagVIO5_41940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VagVIO5_41970	COG0798	PFAM Bile acid sodium symporter
VagVIO5_41990	COG1881	PFAM PEBP family protein
VagVIO5_42010	COG2706	6-phosphogluconolactonase activity
VagVIO5_42030	COG1131	(ABC) transporter
VagVIO5_42040	COG0842	Transport permease protein
VagVIO5_42070	COG3383	formate dehydrogenase (NAD+) activity
VagVIO5_42110	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VagVIO5_42170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VagVIO5_42190	COG2067	long-chain fatty acid transport protein
VagVIO5_42210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VagVIO5_42240	COG1505	serine-type exopeptidase activity
VagVIO5_42250	COG0488	(ABC) transporter
VagVIO5_42260	COG0589	response to stress
VagVIO5_42270	COG2249	NAD(P)H dehydrogenase (quinone) activity
VagVIO5_42310	COG0366	Alpha amylase catalytic
VagVIO5_42320	COG0789	Transcriptional regulator
VagVIO5_42350	COG4934	collagen metabolic process
VagVIO5_42370	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VagVIO5_42380	COG0583	DNA-binding transcription factor activity
VagVIO5_42450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VagVIO5_42460	COG0835	chemotaxis
VagVIO5_42460	COG0784	Response regulator, receiver
VagVIO5_42480	COG0748	coenzyme F420 binding
VagVIO5_42490	COG3721	Heme iron utilization protein
VagVIO5_42510	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VagVIO5_42520	COG0811	peptide transport
VagVIO5_42530	COG0848	biopolymer transport protein
VagVIO5_42550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VagVIO5_42560	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VagVIO5_42650	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VagVIO5_42660	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VagVIO5_42670	COG0633	Ferredoxin
VagVIO5_42670	COG3217	Mosc domain protein beta barrel domain protein
VagVIO5_42670	COG0633	Ferredoxin
VagVIO5_42670	COG3217	Mosc domain protein beta barrel domain protein
VagVIO5_42680	COG0401	homolog of Blt101
VagVIO5_42690	COG0418	dihydroorotase activity
VagVIO5_42700	COG2354	Protein conserved in bacteria
VagVIO5_42760	COG3833	ABC-type maltose transport systems, permease component
VagVIO5_42770	COG1175	transmembrane transport
VagVIO5_42790	COG3842	ATPase activity
VagVIO5_42800	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VagVIO5_42920	COG1309	transcriptional regulator
VagVIO5_42930	COG2130	NADP-dependent
VagVIO5_42950	COG0753	catalase activity
VagVIO5_42960	COG2084	Dehydrogenase
VagVIO5_42970	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VagVIO5_42980	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VagVIO5_43000	COG2207	Transcriptional regulator
VagVIO5_43010	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VagVIO5_43010	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VagVIO5_43010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VagVIO5_43040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VagVIO5_43050	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
VagVIO5_43060	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VagVIO5_43080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VagVIO5_43090	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VagVIO5_43100	COG1012	belongs to the aldehyde dehydrogenase family
VagVIO5_43130	COG0583	DNA-binding transcription factor activity
VagVIO5_43140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VagVIO5_43150	COG0569	domain protein
VagVIO5_43170	COG2205	protein histidine kinase activity
VagVIO5_43170	COG2205	protein histidine kinase activity
VagVIO5_43180	COG1132	(ABC) transporter
VagVIO5_43190	COG4774	siderophore transport
VagVIO5_43200	COG1120	ATPase activity
VagVIO5_43210	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
VagVIO5_43280	COG2197	response regulator
VagVIO5_43300	COG0840	transmembrane signaling receptor activity
VagVIO5_43310	COG0714	Associated with various cellular activities
VagVIO5_43340	COG2304	oxidoreductase activity
VagVIO5_43350	COG2304	oxidoreductase activity
VagVIO5_43380	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VagVIO5_43390	COG0581	inorganic phosphate transmembrane transporter activity
VagVIO5_43400	COG0573	inorganic phosphate transmembrane transporter activity
VagVIO5_43460	COG4771	TonB-dependent receptor
VagVIO5_43470	COG1770	oligopeptidase
VagVIO5_43480	COG0513	Belongs to the DEAD box helicase family
VagVIO5_43500	COG1388	LysM domain
VagVIO5_43500	COG1376	ErfK ybiS ycfS ynhG family protein
VagVIO5_43510	COG0415	Belongs to the DNA photolyase family
VagVIO5_43520	COG0789	Transcriptional regulator
VagVIO5_43530	COG3272	Protein of unknown function (DUF1722)
VagVIO5_43540	COG0813	purine-nucleoside phosphorylase activity
VagVIO5_43570	COG3706	GGDEF domain
VagVIO5_43590	COG1566	PFAM secretion protein HlyD family protein
VagVIO5_43600	COG4720	Psort location CytoplasmicMembrane, score
VagVIO5_43610	COG1122	ATPase activity
VagVIO5_43650	COG0348	domain, Protein
VagVIO5_43660	COG0437	4 iron, 4 sulfur cluster binding
VagVIO5_43670	COG1247	-acetyltransferase
VagVIO5_43710	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VagVIO5_43720	COG0840	transmembrane signaling receptor activity
VagVIO5_43730	COG1067	ATP-dependent peptidase activity
VagVIO5_43750	COG4172	Belongs to the ABC transporter superfamily
VagVIO5_43760	COG1505	serine-type exopeptidase activity
VagVIO5_43770	COG0583	DNA-binding transcription factor activity
VagVIO5_43780	COG1620	l-lactate permease
VagVIO5_43790	COG1304	FMN binding
VagVIO5_43810	COG0668	transmembrane transport
VagVIO5_43830	COG1063	alcohol dehydrogenase
VagVIO5_43840	COG0156	8-amino-7-oxononanoate synthase activity
VagVIO5_43850	COG5001	Diguanylate cyclase
VagVIO5_43850	COG3300	MHYT domain
VagVIO5_43860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VagVIO5_43900	COG0745	RESPONSE REGULATOR receiver
VagVIO5_43950	COG0346	lactoylglutathione lyase activity
VagVIO5_44060	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VagVIO5_44150	COG1987	bacterial-type flagellum assembly
VagVIO5_44170	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
VagVIO5_44200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VagVIO5_44240	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VagVIO5_44250	COG1516	flagellar protein fliS
VagVIO5_44280	COG1580	Controls the rotational direction of flagella during chemotaxis
VagVIO5_44290	COG1191	sigma factor activity
VagVIO5_44300	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VagVIO5_44310	COG1360	Flagellar Motor Protein
VagVIO5_44410	COG1882	Formate acetyltransferase
VagVIO5_44420	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VagVIO5_44430	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VagVIO5_44450	COG0454	-acetyltransferase
VagVIO5_44470	COG2814	Major facilitator Superfamily
VagVIO5_44550	COG0628	permease
VagVIO5_44560	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VagVIO5_44570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VagVIO5_44590	COG4628	conserved protein (DUF2132)
VagVIO5_44600	COG0583	DNA-binding transcription factor activity
VagVIO5_44650	COG1686	Belongs to the peptidase S11 family
VagVIO5_44700	COG0415	Belongs to the DNA photolyase family
VagVIO5_44710	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
VagVIO5_44720	COG3397	chitin binding
VagVIO5_44730	COG4667	esterase of the alpha-beta hydrolase superfamily
VagVIO5_44740	COG2095	MarC family integral membrane protein
VagVIO5_44770	COG1596	polysaccharide export
VagVIO5_44810	COG1301	dicarboxylic acid transport
VagVIO5_44820	COG3339	Conserved Protein
VagVIO5_44840	COG0700	Nucleoside recognition
VagVIO5_44850	COG3366	ferrous iron transmembrane transporter activity
VagVIO5_44870	COG0366	Alpha amylase catalytic
VagVIO5_44880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VagVIO5_44890	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VagVIO5_44900	COG1640	4-alpha-glucanotransferase
VagVIO5_44910	COG0058	SHG alpha-glucan phosphorylase activity
VagVIO5_44920	COG2909	trisaccharide binding
VagVIO5_44950	COG1999	signal sequence binding
VagVIO5_44960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VagVIO5_44960	COG1263	PTS System
VagVIO5_44970	COG1162	GTPase activity
VagVIO5_44980	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
VagVIO5_44990	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
VagVIO5_45010	COG0531	amino acid
VagVIO5_45020	COG1982	Orn Lys Arg decarboxylase major
VagVIO5_45060	COG2356	endonuclease I
VagVIO5_45100	COG4580	involved in the transport of maltose and maltodextrins
VagVIO5_45180	COG0739	heme binding
VagVIO5_45190	COG0612	Peptidase, M16
VagVIO5_45200	COG0840	transmembrane signaling receptor activity
VagVIO5_45210	COG1120	ATPase activity
VagVIO5_45220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VagVIO5_45230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VagVIO5_45240	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
VagVIO5_45250	COG4772	TonB-dependent receptor
VagVIO5_45300	COG4264	IucA IucC family
VagVIO5_45310	COG0019	diaminopimelate decarboxylase activity
VagVIO5_45320	COG1653	transport
VagVIO5_45340	COG0745	RESPONSE REGULATOR receiver
VagVIO5_45410	COG0463	Glycosyl transferase, family 2
VagVIO5_45440	COG1136	(ABC) transporter
VagVIO5_45480	COG1764	response to oxidative stress
VagVIO5_45490	COG1846	Transcriptional regulator
VagVIO5_45510	COG3634	alkyl hydroperoxide reductase activity
VagVIO5_45560	COG1595	DNA-templated transcription, initiation
VagVIO5_45600	COG2258	MOSC domain
VagVIO5_45650	COG2207	Transcriptional regulator
VagVIO5_45670	COG1132	(ABC) transporter
VagVIO5_45760	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VagVIO5_45810	COG0259	pyridoxamine-phosphate oxidase activity
VagVIO5_45910	COG4166	transmembrane transport
VagVIO5_45940	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VagVIO5_45950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VagVIO5_45950	COG1263	PTS System
VagVIO5_45960	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VagVIO5_46000	COG1444	tRNA N-acetyltransferase activity