locus-tag	class	description
H7696_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H7696_00010	COG0592	DNA-directed DNA polymerase activity
H7696_00020	COG0187	DNA topoisomerase II activity
H7696_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
H7696_00035	COG3977	Valine--pyruvate aminotransferase
H7696_00040	COG0366	Alpha amylase catalytic
H7696_00055	COG2119	membrane
H7696_00065	COG0425	Belongs to the sulfur carrier protein TusA family
H7696_00080	COG0604	alcohol dehydrogenase
H7696_00085	COG0183	Belongs to the thiolase family
H7696_00095	COG1739	Uncharacterized protein family UPF0029
H7696_00100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7696_00150	COG2132	Multicopper oxidase
H7696_00170	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7696_00175	COG2104	thiamine diphosphate biosynthetic process
H7696_00190	COG0006	proline dipeptidase activity
H7696_00190	COG0006	proline dipeptidase activity
H7696_00220	COG3220	belongs to the UPF0276 family
H7696_00230	COG0210	DNA helicase
H7696_00235	COG0405	Gamma-glutamyltransferase
H7696_00240	COG1280	lysine exporter protein (LysE YggA)
H7696_00250	COG2962	Rard protein
H7696_00255	COG0514	ATP-dependent DNA helicase (RecQ)
H7696_00265	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H7696_00275	COG0248	Ppx GppA phosphatase
H7696_00280	COG0513	Belongs to the DEAD box helicase family
H7696_00285	COG3118	belongs to the thioredoxin family
H7696_00300	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H7696_00305	COG0633	Ferredoxin
H7696_00345	COG3071	HemY protein
H7696_00350	COG2959	enzyme of heme biosynthesis
H7696_00355	COG1587	Uroporphyrinogen-III synthase
H7696_00360	COG0181	hydroxymethylbilane synthase activity
H7696_00365	COG3072	Adenylate cyclase
H7696_00370	COG1965	Belongs to the frataxin family
H7696_00380	COG0019	diaminopimelate decarboxylase activity
H7696_00395	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H7696_00400	COG1011	Hydrolase
H7696_00405	COG3287	FIST C domain
H7696_00405	COG2200	EAL domain
H7696_00405	COG2199	diguanylate cyclase activity
H7696_00410	COG3148	PFAM DTW domain containing protein
H7696_00425	COG0561	phosphatase activity
H7696_00430	COG2267	carboxylic ester hydrolase activity
H7696_00435	COG1280	lysine exporter protein (LysE YggA)
H7696_00440	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H7696_00445	COG0640	Transcriptional regulator
H7696_00450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7696_00490	COG2095	MarC family integral membrane protein
H7696_00500	COG0742	ribosomal rna small subunit methyltransferase
H7696_00505	COG0552	protein localization to endoplasmic reticulum
H7696_00510	COG2884	Cell division ATP-binding protein ftsE
H7696_00515	COG2177	Part of the ABC transporter FtsEX involved in
H7696_00525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7696_00530	COG0705	Rhomboid family
H7696_00535	COG1580	Controls the rotational direction of flagella during chemotaxis
H7696_00540	COG3161	chorismate lyase activity
H7696_00545	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H7696_00550	COG2937	Belongs to the GPAT DAPAT family
H7696_00555	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H7696_00560	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H7696_00565	COG0534	Mate efflux family protein
H7696_00570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7696_00590	COG4206	TonB-dependent receptor
H7696_00655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7696_00665	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H7696_00670	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H7696_00670	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H7696_00700	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7696_00705	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H7696_00710	COG0250	Participates in transcription elongation, termination and antitermination
H7696_00725	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H7696_00730	COG0222	ribosome binding
H7696_00735	COG0085	RNA polymerase activity
H7696_00740	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H7696_00745	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
H7696_00750	COG2816	NAD+ diphosphatase activity
H7696_00755	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H7696_00760	COG1573	uracil-dna glycosylase
H7696_00770	COG3068	Protein conserved in bacteria
H7696_00775	COG1253	flavin adenine dinucleotide binding
H7696_00790	COG0151	Belongs to the GarS family
H7696_00795	COG0138	bifunctional purine biosynthesis protein purh
H7696_00800	COG0789	Transcriptional regulator
H7696_00805	COG3710	Transcriptional regulator
H7696_00810	COG0531	amino acid
H7696_00815	COG1982	Orn Lys Arg decarboxylase major
H7696_00875	COG0488	(ABC) transporter
H7696_00885	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H7696_00890	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7696_00895	COG2264	protein methyltransferase activity
H7696_00900	COG0439	Biotin carboxylase
H7696_00905	COG0511	ligase activity, forming carbon-carbon bonds
H7696_00910	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H7696_00915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7696_00930	COG2814	Major facilitator Superfamily
H7696_00955	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7696_00965	COG3263	regulation of cellular component size
H7696_00975	COG4232	protein-disulfide reductase activity
H7696_00980	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H7696_00985	COG1027	Aspartate ammonia-lyase
H7696_00990	COG3030	protein affecting phage T7 exclusion by the F plasmid
H7696_00995	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H7696_01005	COG2205	protein histidine kinase activity
H7696_01010	COG0745	RESPONSE REGULATOR receiver
H7696_01015	COG3678	ATP-independent chaperone mediated protein folding
H7696_01025	COG0205	6-phosphofructokinase activity
H7696_01030	COG0534	Mate efflux family protein
H7696_01040	COG0459	protein refolding
H7696_01050	COG1285	pathogenesis
H7696_01055	COG1509	lysine 2,3-aminomutase activity
H7696_01070	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H7696_01075	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H7696_01080	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H7696_01085	COG1053	succinate dehydrogenase
H7696_01090	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H7696_01110	COG4942	peptidase
H7696_01115	COG1045	serine acetyltransferase
H7696_01120	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H7696_01125	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H7696_01130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7696_01135	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H7696_01145	COG0471	metal ion transport
H7696_01150	COG0688	phosphatidylethanolamine metabolic process
H7696_01155	COG1162	GTPase activity
H7696_01160	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H7696_01225	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H7696_01230	COG0802	atpase or kinase
H7696_01240	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H7696_01245	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H7696_01255	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H7696_01260	COG0330	HflC and HflK could
H7696_01265	COG0330	HflC and HflK could
H7696_01270	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
H7696_01275	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H7696_01280	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
H7696_01285	COG1017	nitric oxide dioxygenase activity
H7696_01285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7696_01290	COG1959	2 iron, 2 sulfur cluster binding
H7696_01295	COG0557	exoribonuclease II activity
H7696_01300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7696_01305	COG0546	phosphoglycolate phosphatase activity
H7696_01310	COG0180	Tryptophanyl-tRNA synthetase
H7696_01325	COG0512	Glutamine amidotransferase of anthranilate synthase
H7696_01330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7696_01350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7696_01355	COG3954	Phosphoribulokinase
H7696_01365	COG0429	hydrolase of the alpha beta-hydrolase fold
H7696_01375	COG0488	(ABC) transporter
H7696_01380	COG2249	NAD(P)H dehydrogenase (quinone) activity
H7696_01395	COG1047	Peptidyl-prolyl cis-trans
H7696_01400	COG1446	asparaginase
H7696_01415	COG0545	Peptidyl-prolyl cis-trans isomerase
H7696_01420	COG2964	Protein conserved in bacteria
H7696_01425	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H7696_01430	COG2923	Belongs to the DsrF TusC family
H7696_01450	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H7696_01455	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7696_01470	COG0281	malic enzyme
H7696_01475	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
H7696_01480	COG0626	cystathionine gamma-synthase activity
H7696_01485	COG0527	aspartate kinase activity
H7696_01485	COG0460	homoserine dehydrogenase
H7696_01490	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H7696_01500	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H7696_01510	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H7696_01520	COG0137	argininosuccinate synthase activity
H7696_01525	COG0165	Argininosuccinate lyase
H7696_01525	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H7696_01535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7696_01540	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H7696_01540	COG0678	peroxiredoxin activity
H7696_01550	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H7696_01580	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H7696_01585	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H7696_01595	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H7696_01600	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H7696_01605	COG0360	Binds together with S18 to 16S ribosomal RNA
H7696_01610	COG2965	DNA replication, synthesis of RNA primer
H7696_01635	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7696_01640	COG0432	Pfam Uncharacterised protein family UPF0047
H7696_01645	COG0166	Belongs to the GPI family
H7696_01655	COG0735	belongs to the Fur family
H7696_01660	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7696_01680	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7696_01685	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7696_01690	COG0175	sulfate reduction
H7696_01750	COG1410	methionine synthase
H7696_01750	COG0646	methionine synthase
H7696_01755	COG0527	aspartate kinase activity
H7696_01760	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H7696_01770	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H7696_01785	COG0629	single-stranded DNA binding
H7696_01790	COG2199	diguanylate cyclase activity
H7696_01790	COG2200	EAL domain
H7696_01810	COG1450	Type ii and iii secretion system protein
H7696_01815	COG3267	Type II secretory pathway component ExeA
H7696_01815	COG3409	Peptidoglycan-binding domain 1 protein
H7696_01825	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7696_01830	COG1459	type II secretion system
H7696_01840	COG2165	general secretion pathway protein
H7696_01875	COG1077	Cell shape determining protein MreB Mrl
H7696_01880	COG1792	Involved in formation and maintenance of cell shape
H7696_01885	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H7696_01890	COG0424	maF-like protein
H7696_01900	COG3164	Protein of unknown function
H7696_01905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7696_01910	COG0312	modulator of DNA gyrase
H7696_01915	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H7696_01920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H7696_01930	COG0564	pseudouridine synthase activity
H7696_01935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7696_01940	COG3028	Belongs to the UPF0307 family
H7696_01945	COG0312	modulator of DNA gyrase
H7696_01950	COG2239	Acts as a magnesium transporter
H7696_01955	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7696_01960	COG1660	Displays ATPase and GTPase activities
H7696_01965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7696_01970	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H7696_01980	COG1137	ATPase activity
H7696_01985	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H7696_01995	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H7696_01995	COG0517	IMP dehydrogenase activity
H7696_02005	COG1127	ABC transporter
H7696_02010	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H7696_02015	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H7696_02020	COG2854	intermembrane phospholipid transfer
H7696_02030	COG5007	Belongs to the BolA IbaG family
H7696_02035	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H7696_02040	COG0204	Acyl-transferase
H7696_02045	COG0251	oxidation-reduction process
H7696_02050	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
H7696_02055	COG0540	Belongs to the ATCase OTCase family
H7696_02085	COG0456	acetyltransferase
H7696_02095	COG0525	valine-tRNA ligase activity
H7696_02100	COG2927	DNA polymerase III (CHI subunit)
H7696_02105	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7696_02110	COG0795	lipopolysaccharide-transporting ATPase activity
H7696_02115	COG0795	lipopolysaccharide-transporting ATPase activity
H7696_02130	COG1028	Short-chain dehydrogenase reductase Sdr
H7696_02140	COG0726	polysaccharide deacetylase
H7696_02145	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7696_02150	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7696_02155	COG1447	Phosphotransferase system cellobiose-specific component IIA
H7696_02160	COG1486	melibiose metabolic process
H7696_02165	COG3394	polysaccharide catabolic process
H7696_02170	COG1609	Transcriptional regulator
H7696_02175	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H7696_02250	COG0840	transmembrane signaling receptor activity
H7696_02295	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H7696_02310	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H7696_02320	COG4974	Belongs to the 'phage' integrase family
H7696_02355	COG0784	Response regulator, receiver
H7696_02355	COG2205	protein histidine kinase activity
H7696_02370	COG2264	protein methyltransferase activity
H7696_02375	COG2200	EAL domain
H7696_02385	COG1278	Cold shock
H7696_02405	COG1278	Cold shock
H7696_02415	COG2015	COG2015, Alkyl sulfatase and related hydrolases
H7696_02445	COG1194	a g-specific adenine glycosylase
H7696_02450	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H7696_02460	COG2066	Belongs to the glutaminase family
H7696_02465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7696_02470	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H7696_02480	COG1872	DUF167
H7696_02485	COG0762	integral membrane protein
H7696_02490	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H7696_02495	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H7696_02510	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H7696_02515	COG1678	Uncharacterized ACR, COG1678
H7696_02520	COG0189	ligase activity
H7696_02525	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H7696_02530	COG2356	endonuclease I
H7696_02545	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H7696_02550	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H7696_02555	COG0583	DNA-binding transcription factor activity
H7696_02560	COG4771	TonB-dependent receptor
H7696_02575	COG0191	fructose-bisphosphate aldolase activity
H7696_02580	COG0668	transmembrane transport
H7696_02595	COG0583	DNA-binding transcription factor activity
H7696_02605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7696_02610	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H7696_02615	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H7696_02625	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
H7696_02630	COG3079	Belongs to the UPF0149 family
H7696_02635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7696_02640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7696_02660	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H7696_02670	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H7696_02675	COG1595	DNA-templated transcription, initiation
H7696_02690	COG3086	response to oxidative stress
H7696_02695	COG0481	GTPase activity
H7696_02700	COG0681	Belongs to the peptidase S26 family
H7696_02710	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H7696_02715	COG1381	Involved in DNA repair and RecF pathway recombination
H7696_02720	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H7696_02725	COG0736	holo-[acyl-carrier-protein] synthase activity
H7696_02735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7696_02740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7696_02745	COG3956	TIGRFAM MazG family protein
H7696_02750	COG0504	CTP synthase activity
H7696_02755	COG0148	phosphopyruvate hydratase activity
H7696_02760	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H7696_02765	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H7696_02770	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H7696_02780	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H7696_02785	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7696_02795	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7696_02800	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H7696_02805	COG1546	Belongs to the CinA family
H7696_02810	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H7696_02815	COG2137	regulation of response to DNA damage stimulus
H7696_02820	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H7696_02825	COG0527	aspartate kinase activity
H7696_02885	COG3630	sodium ion export across plasma membrane
H7696_02890	COG0511	ligase activity, forming carbon-carbon bonds
H7696_02890	COG5016	pyruvate
H7696_02895	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
H7696_02905	COG1238	metal cluster binding
H7696_02910	COG0612	Peptidase, M16
H7696_02925	COG1854	S-ribosylhomocysteine lyase activity
H7696_02930	COG4536	flavin adenine dinucleotide binding
H7696_02935	COG4137	Cytochrome C assembly protein
H7696_02940	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H7696_02945	COG0228	four-way junction DNA binding
H7696_02950	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H7696_02965	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H7696_02970	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
H7696_02975	COG0237	dephospho-CoA kinase activity
H7696_02985	COG1459	type II secretion system
H7696_02990	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7696_02995	COG4969	Belongs to the N-Me-Phe pilin family
H7696_03000	COG0157	Belongs to the NadC ModD family
H7696_03010	COG2186	Transcriptional regulator
H7696_03015	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H7696_03020	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7696_03025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7696_03040	COG0288	reversible hydration of carbon dioxide
H7696_03045	COG0659	secondary active sulfate transmembrane transporter activity
H7696_03050	COG1131	(ABC) transporter
H7696_03055	COG0842	Transport permease protein
H7696_03060	COG1560	Kdo2-lipid A biosynthetic process
H7696_03065	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H7696_03070	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H7696_03075	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H7696_03085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7696_03095	COG1489	DNA binding
H7696_03100	COG1643	Atp-dependent helicase
H7696_03105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7696_03110	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7696_03115	COG1049	propionate catabolic process, 2-methylcitrate cycle
H7696_03120	COG3112	Uncharacterised protein family (UPF0231)
H7696_03130	COG0004	ammonium transporteR
H7696_03135	COG1840	ABC-type Fe3 transport system, periplasmic component
H7696_03145	COG3842	ATPase activity
H7696_03150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7696_03165	COG2971	BadF BadG BcrA BcrD
H7696_03175	COG4608	Belongs to the ABC transporter superfamily
H7696_03180	COG0444	Belongs to the ABC transporter superfamily
H7696_03185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7696_03195	COG0747	negative chemotaxis
H7696_03200	COG2205	protein histidine kinase activity
H7696_03200	COG0784	Response regulator, receiver
H7696_03210	COG0628	permease
H7696_03235	COG0739	heme binding
H7696_03240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H7696_03250	COG2027	D-alanyl-D-alanine carboxypeptidase
H7696_03255	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H7696_03260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7696_03265	COG1534	Rna-binding protein
H7696_03270	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H7696_03275	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7696_03280	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H7696_03285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7696_03290	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H7696_03305	COG0779	Required for maturation of 30S ribosomal subunits
H7696_03310	COG0195	Participates in both transcription termination and antitermination
H7696_03315	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H7696_03320	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H7696_03325	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H7696_03330	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H7696_03335	COG1185	polyribonucleotide nucleotidyltransferase activity
H7696_03350	COG0534	Mate efflux family protein
H7696_03355	COG0826	peptidase U32
H7696_03360	COG0826	peptidase U32
H7696_03370	COG3154	lipid carrier protein
H7696_03375	COG3153	acetyltransferase
H7696_03535	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H7696_03570	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H7696_03665	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7696_03685	COG0681	Belongs to the peptidase S26 family
H7696_03720	COG0582	viral genome integration into host DNA
H7696_03730	COG1357	PFAM Pentapeptide repeats (8 copies)
H7696_03750	COG4584	PFAM Integrase catalytic
H7696_03755	COG1484	DNA-dependent DNA replication
H7696_03760	COG3344	reverse transcriptase
H7696_03810	COG0789	Transcriptional regulator
H7696_03825	COG0629	single-stranded DNA binding
H7696_03845	COG0714	Associated with various cellular activities
H7696_03870	COG2003	Belongs to the UPF0758 family
H7696_03970	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H7696_03980	COG0084	hydrolase, TatD family'
H7696_03985	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7696_03990	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H7696_03995	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H7696_04000	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H7696_04005	COG0813	purine-nucleoside phosphorylase activity
H7696_04015	COG0560	Phosphoserine phosphatase
H7696_04025	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H7696_04030	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H7696_04035	COG0583	DNA-binding transcription factor activity
H7696_04045	COG1022	Amp-dependent synthetase and ligase
H7696_04085	COG0583	DNA-binding transcription factor activity
H7696_04090	COG1609	Transcriptional regulator
H7696_04110	COG0598	Magnesium transport protein CorA
H7696_04115	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H7696_04120	COG1349	DNA-binding transcription factor activity
H7696_04125	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H7696_04130	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7696_04135	COG2271	Major facilitator Superfamily
H7696_04140	COG0584	glycerophosphoryl diester phosphodiesterase
H7696_04145	COG2171	N-acyltransferase activity
H7696_04160	COG3141	response to X-ray
H7696_04180	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H7696_04185	COG1074	ATP-dependent DNA helicase activity
H7696_04190	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7696_04200	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H7696_04200	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H7696_04210	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H7696_04215	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H7696_04220	COG2166	iron-sulfur cluster assembly
H7696_04225	COG3706	GGDEF domain
H7696_04230	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H7696_04235	COG0693	protein deglycase activity
H7696_04240	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H7696_04260	COG1595	DNA-templated transcription, initiation
H7696_04280	COG3056	Lipoprotein
H7696_04285	COG2813	Specifically methylates the guanine in position
H7696_04290	COG0271	Belongs to the BolA IbaG family
H7696_04295	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7696_04300	COG1805	sodium ion transport
H7696_04305	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7696_04310	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7696_04315	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7696_04320	COG2871	sodium ion transport
H7696_04325	COG1477	protein flavinylation
H7696_04345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7696_04350	COG0514	ATP-dependent DNA helicase (RecQ)
H7696_04355	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7696_04370	COG0733	neurotransmitter:sodium symporter activity
H7696_04390	COG0442	prolyl-tRNA aminoacylation
H7696_04395	COG1720	tRNA m6t6A37 methyltransferase activity
H7696_04400	COG0254	rRNA binding
H7696_04410	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H7696_04435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7696_04475	COG0564	pseudouridine synthase activity
H7696_04490	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H7696_04495	COG0024	Methionine aminopeptidase
H7696_04500	COG0052	Belongs to the universal ribosomal protein uS2 family
H7696_04505	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H7696_04510	COG0528	UMP kinase activity
H7696_04515	COG0233	cytoplasmic translational termination
H7696_04520	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H7696_04525	COG0575	Belongs to the CDS family
H7696_04530	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H7696_04535	COG0750	zinc metalloprotease
H7696_04545	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
H7696_04550	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7696_04560	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7696_04565	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7696_04575	COG0587	DNA-directed DNA polymerase activity
H7696_04580	COG0825	malonyl-CoA metabolic process
H7696_04595	COG0347	Belongs to the P(II) protein family
H7696_04600	COG3021	interspecies interaction between organisms
H7696_04610	COG1388	LysM domain
H7696_04610	COG0741	lytic transglycosylase activity
H7696_04615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7696_04620	COG2226	methyltransferase
H7696_04625	COG0328	RNA-DNA hybrid ribonuclease activity
H7696_04660	COG1960	acyl-CoA dehydrogenase activity
H7696_04665	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H7696_04670	COG0121	glutamine amidotransferase
H7696_04675	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H7696_04680	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H7696_04685	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H7696_04690	COG2233	PERMEase
H7696_04710	COG1393	Belongs to the ArsC family
H7696_04715	COG4783	chaperone-mediated protein folding
H7696_04730	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H7696_04740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7696_04745	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H7696_04760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7696_04765	COG1393	Belongs to the ArsC family
H7696_04790	COG2837	iron assimilation
H7696_04795	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7696_04800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7696_04805	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7696_04810	COG1334	flagellar protein FlaG
H7696_04815	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H7696_04825	COG1516	flagellar protein fliS
H7696_04845	COG1677	Flagellar hook-basal body complex protein FliE
H7696_04855	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7696_04910	COG1987	bacterial-type flagellum assembly
H7696_04915	COG1684	flagellar biosynthetic protein fliR
H7696_04950	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
H7696_04955	COG0784	Response regulator, receiver
H7696_04955	COG2198	Histidine kinase
H7696_04955	COG0643	Histidine kinase
H7696_04960	COG2201	protein-glutamate methylesterase activity
H7696_04965	COG1192	Involved in chromosome partitioning
H7696_04975	COG0835	chemotaxis
H7696_04985	COG4133	protoheme IX ABC transporter activity
H7696_04990	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7696_04995	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7696_05000	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7696_05005	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H7696_05010	COG1138	Cytochrome C-type biogenesis protein
H7696_05015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7696_05025	COG4235	cytochrome complex assembly
H7696_05025	COG3088	subunit of a heme lyase
H7696_05035	COG2067	long-chain fatty acid transport protein
H7696_05055	COG0183	Belongs to the thiolase family
H7696_05060	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7696_05060	COG1024	Enoyl-CoA hydratase
H7696_05075	COG2062	phosphohistidine phosphatase, SixA
H7696_05080	COG2840	Smr protein MutS2
H7696_05085	COG2890	protein-(glutamine-N5) methyltransferase activity
H7696_05090	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H7696_05095	COG2860	membrane
H7696_05100	COG3101	peptidyl-lysine hydroxylation
H7696_05115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7696_05115	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H7696_05120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7696_05125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7696_05130	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H7696_05140	COG0101	tRNA pseudouridine synthase activity
H7696_05145	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H7696_05150	COG0285	dihydrofolate synthase activity
H7696_05155	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
H7696_05160	COG1286	toxin biosynthetic process
H7696_05165	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H7696_05170	COG0583	DNA-binding transcription factor activity
H7696_05175	COG0745	RESPONSE REGULATOR receiver
H7696_05180	COG2832	Protein of unknown function (DUF454)
H7696_05185	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7696_05200	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H7696_05205	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7696_05215	COG2261	transglycosylase associated protein
H7696_05220	COG2983	Belongs to the UPF0260 family
H7696_05225	COG0668	transmembrane transport
H7696_05230	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H7696_05235	COG0346	lactoylglutathione lyase activity
H7696_05245	COG1785	Belongs to the alkaline phosphatase family
H7696_05260	COG2226	methyltransferase
H7696_05275	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7696_05280	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7696_05290	COG3139	Protein of unknown function (DUF1315)
H7696_05295	COG0252	asparaginase activity
H7696_05300	COG0616	signal peptide processing
H7696_05305	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7696_05305	COG1902	pentaerythritol trinitrate reductase activity
H7696_05315	COG0778	Nitroreductase
H7696_05320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H7696_05335	COG0123	including yeast histone deacetylase and acetoin utilization protein
H7696_05350	COG3082	Protein of unknown function (DUF1414)
H7696_05355	COG3081	Nucleoid-associated protein
H7696_05370	COG1757	Na H antiporter
H7696_05375	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H7696_05380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7696_05385	COG2095	MarC family integral membrane protein
H7696_05390	COG1012	belongs to the aldehyde dehydrogenase family
H7696_05390	COG1454	alcohol dehydrogenase
H7696_05410	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H7696_05415	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H7696_05520	COG4695	Portal protein
H7696_05570	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H7696_05655	COG2056	Na+-H+ antiporter family
H7696_05660	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7696_05665	COG2885	chlorophyll binding
H7696_05675	COG0346	lactoylglutathione lyase activity
H7696_05680	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H7696_05685	COG4660	Part of a membrane complex involved in electron transport
H7696_05690	COG4659	FMN binding
H7696_05695	COG4658	electron transport chain
H7696_05700	COG4656	Part of a membrane complex involved in electron transport
H7696_05705	COG2878	Part of a membrane complex involved in electron transport
H7696_05710	COG4657	Part of a membrane complex involved in electron transport
H7696_05715	COG1882	Formate acetyltransferase
H7696_05725	COG0556	nucleotide-excision repair
H7696_05730	COG2204	response regulator
H7696_05735	COG2198	Histidine kinase
H7696_05740	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H7696_05745	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H7696_05750	COG0521	Mo-molybdopterin cofactor biosynthetic process
H7696_05755	COG0315	cyclic pyranopterin monophosphate synthase activity
H7696_05760	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H7696_05765	COG0314	molybdopterin synthase activity
H7696_05775	COG0601	transmembrane transport
H7696_05780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7696_05785	COG0444	Belongs to the ABC transporter superfamily
H7696_05795	COG0435	Glutathione S-transferase
H7696_05805	COG0280	phosphate acetyltransferase
H7696_05805	COG0857	belongs to the CobB CobQ family
H7696_05810	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H7696_05815	COG3092	negative regulation of chromosome organization
H7696_05825	COG4120	Belongs to the binding-protein-dependent transport system permease family
H7696_05830	COG1122	ATPase activity
H7696_05835	COG0366	Alpha amylase catalytic
H7696_05840	COG3706	GGDEF domain
H7696_05845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7696_05850	COG3012	SEC-C Motif Domain Protein
H7696_05850	COG3318	Belongs to the UPF0149 family
H7696_05855	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H7696_05860	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7696_05865	COG2186	Transcriptional regulator
H7696_05875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7696_05875	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7696_05885	COG0572	uridine kinase
H7696_05895	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
H7696_05900	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H7696_05910	COG0659	secondary active sulfate transmembrane transporter activity
H7696_05915	COG1530	ribonuclease E activity
H7696_05920	COG0564	pseudouridine synthase activity
H7696_05925	COG0424	maF-like protein
H7696_05930	COG1399	metal-binding, possibly nucleic acid-binding protein
H7696_05940	COG0416	fatty acid biosynthetic process
H7696_05945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7696_05975	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H7696_05980	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H7696_05985	COG0470	DNA polymerase III
H7696_05990	COG0084	hydrolase, TatD family'
H7696_05995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7696_05995	COG1263	PTS System
H7696_06010	COG0733	neurotransmitter:sodium symporter activity
H7696_06025	COG4667	esterase of the alpha-beta hydrolase superfamily
H7696_06030	COG0469	pyruvate kinase activity
H7696_06035	COG1940	carbohydrate kinase activity
H7696_06040	COG0784	Response regulator, receiver
H7696_06040	COG0835	chemotaxis
H7696_06045	COG0587	DNA-directed DNA polymerase activity
H7696_06060	COG1028	Short-chain dehydrogenase reductase Sdr
H7696_06065	COG0616	signal peptide processing
H7696_06070	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H7696_06075	COG0539	negative regulation of cytoplasmic translation
H7696_06085	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
H7696_06090	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H7696_06100	COG4166	transmembrane transport
H7696_06120	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H7696_06120	COG3008	intermembrane lipid transfer
H7696_06125	COG2995	paraquat-inducible protein a
H7696_06130	COG3258	Cytochrome c
H7696_06135	COG2863	cytochrome
H7696_06170	COG4232	protein-disulfide reductase activity
H7696_06175	COG3118	belongs to the thioredoxin family
H7696_06200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7696_06210	COG1136	(ABC) transporter
H7696_06210	COG0577	efflux transmembrane transporter activity
H7696_06220	COG0577	efflux transmembrane transporter activity
H7696_06220	COG1136	(ABC) transporter
H7696_06270	COG5002	protein histidine kinase activity
H7696_06270	COG3850	Histidine kinase
H7696_06275	COG0745	RESPONSE REGULATOR receiver
H7696_06280	COG0463	Glycosyl transferase, family 2
H7696_06285	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H7696_06305	COG1032	radical SAM domain protein
H7696_06310	COG5001	Diguanylate cyclase
H7696_06325	COG0583	DNA-binding transcription factor activity
H7696_06330	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H7696_06340	COG2350	Protein conserved in bacteria
H7696_06350	COG2917	probably involved in intracellular septation
H7696_06370	COG1301	dicarboxylic acid transport
H7696_06375	COG0318	PFAM AMP-dependent synthetase and ligase
H7696_06380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7696_06385	COG0159	tryptophan synthase activity
H7696_06395	COG0134	indole-3-glycerol-phosphate synthase activity
H7696_06395	COG0135	phosphoribosylanthranilate isomerase activity
H7696_06405	COG0512	Glutamine amidotransferase of anthranilate synthase
H7696_06410	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H7696_06420	COG0613	PHP domain protein
H7696_06425	COG0009	L-threonylcarbamoyladenylate synthase
H7696_06435	COG1187	pseudouridine synthase activity
H7696_06455	COG0417	DNA replication proofreading
H7696_06460	COG2197	response regulator
H7696_06465	COG0322	excinuclease ABC activity
H7696_06505	COG0019	diaminopimelate decarboxylase activity
H7696_06535	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7696_06540	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7696_06560	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
H7696_06570	COG0437	4 iron, 4 sulfur cluster binding
H7696_06575	COG3301	Polysulphide reductase, NrfD
H7696_06580	COG1138	Cytochrome C-type biogenesis protein
H7696_06590	COG4235	cytochrome complex assembly
H7696_06590	COG3088	subunit of a heme lyase
H7696_06600	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7696_06625	COG2989	Protein conserved in bacteria
H7696_06630	COG3108	Peptidase M15
H7696_06635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7696_06650	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H7696_06680	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H7696_06685	COG0840	transmembrane signaling receptor activity
H7696_06705	COG1448	Aminotransferase
H7696_06720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7696_06730	COG0017	Asparaginyl-tRNA synthetase
H7696_06735	COG0840	transmembrane signaling receptor activity
H7696_06740	COG0720	synthase
H7696_06750	COG2200	EAL domain
H7696_06755	COG1760	l-serine dehydratase
H7696_06760	COG0814	amino acid
H7696_06765	COG0494	nUDIX hydrolase
H7696_06775	COG2205	protein histidine kinase activity
H7696_06775	COG0784	Response regulator, receiver
H7696_06780	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H7696_06795	COG3106	COG3106 Predicted ATPase
H7696_06800	COG3768	UPF0283 membrane protein
H7696_06810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7696_06840	COG0346	lactoylglutathione lyase activity
H7696_06905	COG3313	Fe-S protein
H7696_07015	COG0456	acetyltransferase
H7696_07175	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H7696_07235	COG1714	RDD family
H7696_07465	COG0456	acetyltransferase
H7696_07615	COG1280	lysine exporter protein (LysE YggA)
H7696_07780	COG0110	maltose O-acetyltransferase activity
H7696_07785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7696_07790	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H7696_07810	COG5507	3-demethylubiquinone-9 3-methyltransferase
H7696_07815	COG1280	lysine exporter protein (LysE YggA)
H7696_07820	COG1280	lysine exporter protein (LysE YggA)
H7696_07830	COG0729	surface antigen
H7696_07835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7696_07840	COG2272	Belongs to the type-B carboxylesterase lipase family
H7696_07865	COG2985	domain, Protein
H7696_07875	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H7696_07890	COG0583	DNA-binding transcription factor activity
H7696_07905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7696_07920	COG3290	protein histidine kinase activity
H7696_07925	COG4565	transcriptional regulatory protein
H7696_07935	COG2207	Transcriptional regulator
H7696_07940	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H7696_07945	COG0363	glucosamine-6-phosphate deaminase activity
H7696_07950	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H7696_07965	COG3284	Transcriptional regulator
H7696_07970	COG1012	belongs to the aldehyde dehydrogenase family
H7696_08040	COG4669	(LipO)protein
H7696_08060	COG3177	Filamentation induced by cAMP protein fic
H7696_08090	COG2207	Transcriptional regulator
H7696_08095	COG4792	protein secretion
H7696_08100	COG4791	protein targeting
H7696_08105	COG4794	Type iii secretion
H7696_08110	COG4790	Type iii secretion
H7696_08180	COG0457	Tetratricopeptide repeat
H7696_08205	COG2358	TRAP transporter, solute receptor (TAXI family
H7696_08210	COG0730	response to heat
H7696_08245	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H7696_08250	COG0372	Belongs to the citrate synthase family
H7696_08260	COG2828	Protein conserved in bacteria
H7696_08285	COG0561	phosphatase activity
H7696_08290	COG0602	queuosine metabolic process
H7696_08295	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H7696_08310	COG0583	DNA-binding transcription factor activity
H7696_08315	COG0583	DNA-binding transcription factor activity
H7696_08330	COG0583	DNA-binding transcription factor activity
H7696_08345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7696_08350	COG0765	amino acid transport
H7696_08355	COG1126	abc transporter atp-binding protein
H7696_08360	COG1410	methionine synthase
H7696_08360	COG0646	methionine synthase
H7696_08375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7696_08380	COG1335	isochorismatase
H7696_08400	COG2814	Major facilitator Superfamily
H7696_08405	COG0583	DNA-binding transcription factor activity
H7696_08410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7696_08415	COG0583	DNA-binding transcription factor activity
H7696_08420	COG0656	L-ascorbic acid biosynthetic process
H7696_08430	COG1414	Transcriptional regulator
H7696_08435	COG2203	Gaf domain
H7696_08435	COG2199	diguanylate cyclase activity
H7696_08460	COG2885	chlorophyll binding
H7696_08485	COG0840	transmembrane signaling receptor activity
H7696_08490	COG1254	Belongs to the acylphosphatase family
H7696_08495	COG2920	part of a sulfur-relay system
H7696_08505	COG0670	Belongs to the BI1 family
H7696_08510	COG1126	abc transporter atp-binding protein
H7696_08515	COG0765	amino acid transport
H7696_08520	COG4597	amino acid ABC transporter
H7696_08530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7696_08540	COG1666	GTP binding
H7696_08545	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7696_08570	COG3008	intermembrane lipid transfer
H7696_08575	COG2995	paraquat-inducible protein a
H7696_08580	COG1132	(ABC) transporter
H7696_08585	COG1956	GAF domain-containing protein
H7696_08590	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
H7696_08605	COG0308	aminopeptidase N
H7696_08615	COG2902	Dehydrogenase
H7696_08620	COG0167	dihydroorotate dehydrogenase activity
H7696_08630	COG0116	Belongs to the methyltransferase superfamily
H7696_08630	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H7696_08640	COG0488	(ABC) transporter
H7696_08655	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7696_08660	COG1067	ATP-dependent peptidase activity
H7696_08665	COG3120	sequence-specific DNA binding
H7696_08680	COG2205	protein histidine kinase activity
H7696_08680	COG0784	Response regulator, receiver
H7696_08695	COG3278	Belongs to the heme-copper respiratory oxidase family
H7696_08710	COG2010	Cytochrome c
H7696_08720	COG2217	Heavy metal translocating P-type atpase
H7696_08735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7696_08740	COG0589	response to stress
H7696_08765	COG3842	ATPase activity
H7696_08775	COG1177	transmembrane transport
H7696_08785	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H7696_08790	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H7696_08800	COG0004	ammonium transporteR
H7696_08825	COG0437	4 iron, 4 sulfur cluster binding
H7696_08830	COG0243	molybdopterin cofactor binding
H7696_08830	COG3383	formate dehydrogenase (NAD+) activity
H7696_08840	COG3381	protein complex oligomerization
H7696_08860	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H7696_08865	COG0488	(ABC) transporter
H7696_08870	COG3852	Histidine kinase
H7696_08875	COG2204	response regulator
H7696_08890	COG3842	ATPase activity
H7696_08895	COG0746	molybdenum cofactor guanylyltransferase activity
H7696_08900	COG0303	'Molybdopterin
H7696_08910	COG1940	carbohydrate kinase activity
H7696_08915	COG3148	PFAM DTW domain containing protein
H7696_08945	COG0791	NLP P60 protein
H7696_08955	COG3706	GGDEF domain
H7696_08965	COG3001	Fructosamine kinase
H7696_08975	COG0307	riboflavin synthase, alpha
H7696_08980	COG0534	Mate efflux family protein
H7696_08990	COG1793	dna ligase
H7696_09020	COG2204	response regulator
H7696_09025	COG0438	transferase activity, transferring glycosyl groups
H7696_09030	COG0438	transferase activity, transferring glycosyl groups
H7696_09060	COG0438	transferase activity, transferring glycosyl groups
H7696_09065	COG1215	transferase activity, transferring glycosyl groups
H7696_09070	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H7696_09080	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H7696_09095	COG1643	Atp-dependent helicase
H7696_09100	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7696_09145	COG0443	Heat shock 70 kDa protein
H7696_09150	COG0443	Heat shock 70 kDa protein
H7696_09170	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H7696_09175	COG0583	DNA-binding transcription factor activity
H7696_09190	COG1132	(ABC) transporter
H7696_09195	COG1132	(ABC) transporter
H7696_09205	COG4774	siderophore transport
H7696_09215	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7696_09220	COG1120	ATPase activity
H7696_09235	COG0814	amino acid
H7696_09245	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H7696_09255	COG0861	Integral membrane protein TerC family
H7696_09265	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7696_09270	COG1328	CTP reductase activity
H7696_09285	COG5001	Diguanylate cyclase
H7696_09285	COG3300	MHYT domain
H7696_09300	COG0471	metal ion transport
H7696_09325	COG4702	Belongs to the UPF0303 family
H7696_09330	COG0673	inositol 2-dehydrogenase activity
H7696_09335	COG1349	DNA-binding transcription factor activity
H7696_09350	COG1538	Outer membrane efflux protein
H7696_09375	COG3119	arylsulfatase activity
H7696_09390	COG0641	radical SAM
H7696_09405	COG3119	arylsulfatase activity
H7696_09410	COG0527	aspartate kinase activity
H7696_09415	COG0662	Cupin 2, conserved barrel domain protein
H7696_09420	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H7696_09425	COG0456	acetyltransferase
H7696_09430	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H7696_09450	COG4176	ABC-type proline glycine betaine transport system permease component
H7696_09455	COG2113	Glycine betaine
H7696_09460	COG1368	sulfuric ester hydrolase activity
H7696_09485	COG1115	amino acid carrier protein
H7696_09495	COG1280	lysine exporter protein (LysE YggA)
H7696_09500	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H7696_09505	COG1560	Kdo2-lipid A biosynthetic process
H7696_09520	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H7696_09525	COG3063	Type IV pilus biogenesis stability protein PilW
H7696_09565	COG2315	Protein conserved in bacteria
H7696_09570	COG1846	Transcriptional regulator
H7696_09580	COG2200	EAL domain
H7696_09585	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H7696_09590	COG1012	belongs to the aldehyde dehydrogenase family
H7696_09595	COG2957	Belongs to the agmatine deiminase family
H7696_09605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7696_09610	COG1012	belongs to the aldehyde dehydrogenase family
H7696_09615	COG1917	Cupin 2, conserved barrel domain protein
H7696_09615	COG1396	sequence-specific DNA binding
H7696_09620	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H7696_09625	COG0174	glutamine synthetase
H7696_09630	COG1757	Na H antiporter
H7696_09645	COG1742	UPF0060 membrane protein
H7696_09670	COG3755	Protein conserved in bacteria
H7696_09720	COG0625	glutathione transferase activity
H7696_09730	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H7696_09740	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7696_09750	COG0601	transmembrane transport
H7696_09755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7696_09775	COG3291	Pkd domain containing protein
H7696_09785	COG1177	transmembrane transport
H7696_09790	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7696_09795	COG3842	ATPase activity
H7696_09800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7696_09805	COG2423	ornithine cyclodeaminase activity
H7696_09820	COG3938	Belongs to the proline racemase family
H7696_09850	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
H7696_09855	COG1451	nucleotide metabolic process
H7696_09865	COG0583	DNA-binding transcription factor activity
H7696_09885	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
H7696_09890	COG4139	cobalamin transport
H7696_09895	COG2988	succinylglutamate desuccinylase activity
H7696_09915	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H7696_09920	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H7696_09925	COG0702	epimerase
H7696_09930	COG1823	symporter activity
H7696_09935	COG2925	Exonuclease
H7696_09940	COG1380	Effector of murein hydrolase LrgA
H7696_09945	COG1346	cytolysis
H7696_09950	COG0295	cytidine deaminase activity
H7696_09955	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H7696_09960	COG0500	methyltransferase
H7696_09970	COG0776	regulation of translation
H7696_09980	COG0072	phenylalanine-tRNA ligase activity
H7696_09980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7696_09985	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H7696_10020	COG0393	Putative heavy-metal-binding
H7696_10030	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H7696_10040	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H7696_10055	COG2188	Transcriptional regulator
H7696_10060	COG1228	amidohydrolase
H7696_10065	COG0010	Belongs to the arginase family
H7696_10070	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H7696_10075	COG2986	histidine ammonia-lyase
H7696_10090	COG0277	FAD linked oxidase domain protein
H7696_10090	COG0247	lactate metabolic process
H7696_10125	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H7696_10140	COG1643	Atp-dependent helicase
H7696_10145	COG0281	malic enzyme
H7696_10150	COG2949	membrane
H7696_10155	COG0471	metal ion transport
H7696_10180	COG0492	ferredoxin-NADP+ reductase activity
H7696_10185	COG4988	ABC transporter
H7696_10190	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H7696_10200	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H7696_10210	COG4191	Histidine kinase
H7696_10210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7696_10225	COG3070	regulator of competence-specific genes
H7696_10235	COG2431	L-lysine efflux transmembrane transporter activity
H7696_10245	COG0076	glutamate decarboxylase activity
H7696_10250	COG1737	Transcriptional regulator
H7696_10260	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H7696_10265	COG2985	domain, Protein
H7696_10265	COG3273	potassium ion transport
H7696_10270	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7696_10275	COG1960	acyl-CoA dehydrogenase activity
H7696_10285	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7696_10305	COG0534	Mate efflux family protein
H7696_10310	COG0702	epimerase
H7696_10320	COG2814	Major facilitator Superfamily
H7696_10325	COG1187	pseudouridine synthase activity
H7696_10330	COG1061	Type III restriction enzyme res subunit
H7696_10350	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H7696_10370	COG3313	Fe-S protein
H7696_10380	COG4134	Bacterial extracellular solute-binding protein
H7696_10385	COG4135	transport system, permease component
H7696_10390	COG4136	ATPase activity
H7696_10395	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H7696_10405	COG3604	Transcriptional regulator
H7696_10410	COG1151	hydroxylamine reductase activity
H7696_10415	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7696_10425	COG0564	pseudouridine synthase activity
H7696_10430	COG0733	neurotransmitter:sodium symporter activity
H7696_10440	COG0626	cystathionine gamma-synthase activity
H7696_10445	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H7696_10450	COG5380	lipid catabolic process
H7696_10455	COG2818	Glycosylase
H7696_10475	COG1983	PspC domain protein
H7696_10485	COG1842	Phage shock protein A
H7696_10490	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H7696_10505	COG4171	peptide transport system, permease
H7696_10515	COG4172	Belongs to the ABC transporter superfamily
H7696_10525	COG1227	inorganic diphosphatase activity
H7696_10540	COG0243	molybdopterin cofactor binding
H7696_10545	COG3005	denitrification pathway
H7696_10550	COG4459	periplasmic nitrate reductase
H7696_10555	COG0390	transport system, permease component
H7696_10565	COG2116	formate transmembrane transporter activity
H7696_10590	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H7696_10595	COG1435	thymidine kinase activity
H7696_10600	COG0215	cysteine-tRNA ligase activity
H7696_10605	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H7696_10610	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7696_10615	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H7696_10620	COG3012	SEC-C Motif Domain Protein
H7696_10625	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H7696_10625	COG0140	phosphoribosyl-ATP diphosphatase activity
H7696_10635	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H7696_10640	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H7696_10645	COG0131	Imidazoleglycerol-phosphate dehydratase
H7696_10645	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H7696_10655	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H7696_10665	COG1757	Na H antiporter
H7696_10675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7696_10690	COG2915	High frequency lysogenization protein hflD homolog
H7696_10695	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H7696_10705	COG2268	Band 7 protein
H7696_10715	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H7696_10730	COG0300	oxidoreductase activity
H7696_10750	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H7696_10755	COG2226	methyltransferase
H7696_10755	COG1073	alpha beta
H7696_10770	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7696_10775	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H7696_10795	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H7696_10805	COG1674	ftsk spoiiie
H7696_10815	COG0686	Belongs to the AlaDH PNT family
H7696_10825	COG0583	DNA-binding transcription factor activity
H7696_10850	COG3568	Endonuclease Exonuclease Phosphatase
H7696_10875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7696_10880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7696_10905	COG1294	oxidase, subunit
H7696_10915	COG1401	restriction endodeoxyribonuclease activity
H7696_10985	COG2003	Belongs to the UPF0758 family
H7696_11030	COG4983	Phage plasmid primase, P4 family domain protein
H7696_11035	COG3311	Transcriptional regulator
H7696_11055	COG0582	viral genome integration into host DNA
H7696_11070	COG5002	protein histidine kinase activity
H7696_11070	COG0784	Response regulator, receiver
H7696_11080	COG0754	glutathionylspermidine amidase activity
H7696_11090	COG3766	membrane
H7696_11100	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H7696_11105	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
H7696_11110	COG2885	chlorophyll binding
H7696_11115	COG0823	Involved in the tonB-independent uptake of proteins
H7696_11130	COG0811	peptide transport
H7696_11135	COG0824	Thioesterase
H7696_11145	COG4890	Cyd operon protein YbgT
H7696_11150	COG1294	oxidase, subunit
H7696_11155	COG1271	oxidase subunit
H7696_11160	COG2255	four-way junction helicase activity
H7696_11165	COG0632	four-way junction helicase activity
H7696_11170	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H7696_11175	COG0217	transcriptional regulatory protein
H7696_11185	COG1801	Protein of unknown function DUF72
H7696_11195	COG0500	methyltransferase
H7696_11200	COG0189	ligase activity
H7696_11200	COG4067	protein conserved in archaea
H7696_11220	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H7696_11225	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
H7696_11230	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
H7696_11235	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7696_11240	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H7696_11245	COG0745	RESPONSE REGULATOR receiver
H7696_11250	COG3381	protein complex oligomerization
H7696_11255	COG1609	Transcriptional regulator
H7696_11260	COG3070	regulator of competence-specific genes
H7696_11280	COG0297	glycogen (starch) synthase activity
H7696_11285	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H7696_11290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H7696_11310	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H7696_11315	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H7696_11320	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H7696_11325	COG0542	response to heat
H7696_11330	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H7696_11335	COG1278	Cold shock
H7696_11345	COG1187	pseudouridine synthase activity
H7696_11350	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H7696_11355	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H7696_11360	COG1199	ATP-dependent helicase activity
H7696_11365	COG0730	response to heat
H7696_11370	COG3923	Primosomal replication protein n
H7696_11380	COG0708	Exodeoxyribonuclease III
H7696_11420	COG1882	Formate acetyltransferase
H7696_11430	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7696_11440	COG3013	Belongs to the UPF0304 family
H7696_11445	COG2766	serine protein kinase
H7696_11450	COG2718	Belongs to the UPF0229 family
H7696_11455	COG2719	SpoVR family
H7696_11475	COG1132	(ABC) transporter
H7696_11480	COG0658	competence protein
H7696_11480	COG2333	competence protein COMEC
H7696_11490	COG4591	ABC-type transport system involved in lipoprotein release permease component
H7696_11495	COG1136	(ABC) transporter
H7696_11500	COG4591	ABC-type transport system involved in lipoprotein release permease component
H7696_11510	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H7696_11525	COG1252	NADH dehydrogenase
H7696_11530	COG3150	esterase
H7696_11555	COG0537	adenosine 5'-monophosphoramidase activity
H7696_11580	COG0517	IMP dehydrogenase activity
H7696_11580	COG0516	GMP reductase activity
H7696_11585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7696_11610	COG3126	Type III secretion system lipoprotein chaperone (YscW)
H7696_11615	COG1946	Acyl-CoA thioesterase
H7696_11625	COG1522	sequence-specific DNA binding
H7696_11630	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7696_11645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7696_11650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7696_11695	COG0477	Major facilitator Superfamily
H7696_11700	COG2855	membrane
H7696_11720	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H7696_11730	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H7696_11735	COG1169	isochorismate synthase
H7696_11740	COG0436	Aminotransferase
H7696_11745	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
H7696_11750	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H7696_11765	COG1555	photosystem II stabilization
H7696_11770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7696_11775	COG0776	regulation of translation
H7696_11780	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H7696_11785	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H7696_11795	COG0544	peptidyl-prolyl cis-trans isomerase activity
H7696_11810	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H7696_11815	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H7696_11820	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H7696_11825	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H7696_11840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7696_11845	COG0569	domain protein
H7696_11850	COG0513	Belongs to the DEAD box helicase family
H7696_11885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7696_11890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7696_11905	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7696_11910	COG1216	Glycosyl transferase, family 2
H7696_11915	COG2986	histidine ammonia-lyase
H7696_11940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7696_11950	COG1028	Short-chain dehydrogenase reductase Sdr
H7696_11960	COG2226	methyltransferase
H7696_11970	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H7696_11975	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7696_11985	COG2951	lytic endotransglycosylase activity
H7696_11990	COG3100	YcgL domain-containing protein
H7696_11995	COG0850	regulation of cytokinetic process
H7696_12000	COG2894	cell division
H7696_12005	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H7696_12010	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H7696_12015	COG0318	PFAM AMP-dependent synthetase and ligase
H7696_12020	COG2267	carboxylic ester hydrolase activity
H7696_12025	COG3065	identical protein binding
H7696_12035	COG1214	PFAM Peptidase M22, glycoprotease
H7696_12040	COG1199	ATP-dependent helicase activity
H7696_12045	COG0788	formyltetrahydrofolate deformylase activity
H7696_12060	COG3102	Protein conserved in bacteria
H7696_12065	COG0018	arginyl-trna synthetase
H7696_12090	COG1918	ferrous iron import across plasma membrane
H7696_12095	COG4977	sequence-specific DNA binding
H7696_12100	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
H7696_12105	COG1121	(ABC) transporter
H7696_12110	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H7696_12120	COG0045	succinate-CoA ligase (ADP-forming) activity
H7696_12125	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7696_12130	COG0567	Dehydrogenase, E1 component
H7696_12135	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H7696_12140	COG1053	succinate dehydrogenase
H7696_12145	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H7696_12160	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H7696_12170	COG0033	Phosphoglucomutase
H7696_12175	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
H7696_12180	COG0596	Alpha beta hydrolase
H7696_12190	COG0716	FMN binding
H7696_12200	COG0735	belongs to the Fur family
H7696_12205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7696_12210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7696_12210	COG1263	PTS System
H7696_12210	COG2190	(PTS) system
H7696_12215	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H7696_12220	COG1940	carbohydrate kinase activity
H7696_12220	COG1846	Transcriptional regulator
H7696_12225	COG4651	solute:proton antiporter activity
H7696_12225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H7696_12230	COG0367	asparagine synthase
H7696_12235	COG0250	Participates in transcription elongation, termination and antitermination
H7696_12240	COG3104	oligopeptide transport
H7696_12245	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H7696_12255	COG0326	Molecular chaperone. Has ATPase activity
H7696_12260	COG3710	Transcriptional regulator
H7696_12280	COG0622	Phosphoesterase
H7696_12305	COG1090	epimerase
H7696_12310	COG0300	oxidoreductase activity
H7696_12315	COG3118	belongs to the thioredoxin family
H7696_12325	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H7696_12335	COG1215	transferase activity, transferring glycosyl groups
H7696_12340	COG1192	Involved in chromosome partitioning
H7696_12360	COG2194	sulfuric ester hydrolase activity
H7696_12365	COG0330	HflC and HflK could
H7696_12385	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H7696_12390	COG3115	cell septum assembly
H7696_12395	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
H7696_12400	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7696_12405	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7696_12410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7696_12415	COG2190	(PTS) system
H7696_12420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7696_12425	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7696_12430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7696_12435	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7696_12445	COG1705	Flagellar rod assembly protein muramidase FlgJ
H7696_12445	COG3951	Flagellar rod assembly protein muramidase FlgJ
H7696_12450	COG1706	bacterial-type flagellum-dependent cell motility
H7696_12455	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H7696_12465	COG4787	bacterial-type flagellum-dependent cell motility
H7696_12470	COG1749	Flagellar hook protein flgE
H7696_12480	COG1558	bacterial-type flagellum-dependent cell motility
H7696_12485	COG1815	bacterial-type flagellum-dependent cell motility
H7696_12490	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H7696_12495	COG0784	Response regulator, receiver
H7696_12495	COG0835	chemotaxis
H7696_12550	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H7696_12560	COG2217	Heavy metal translocating P-type atpase
H7696_12560	COG2608	mercury ion transmembrane transporter activity
H7696_12600	COG2840	Smr protein MutS2
H7696_12605	COG1187	pseudouridine synthase activity
H7696_12610	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H7696_12615	COG0737	Belongs to the 5'-nucleotidase family
H7696_12620	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H7696_12625	COG2912	Transglutaminase-like superfamily
H7696_12630	COG3094	Invasion gene expression up-regulator, SirB
H7696_12635	COG2890	protein-(glutamine-N5) methyltransferase activity
H7696_12645	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H7696_12650	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H7696_12655	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H7696_12660	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H7696_12665	COG0193	aminoacyl-tRNA hydrolase activity
H7696_12670	COG0012	GTP binding
H7696_12775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7696_12780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7696_12785	COG1702	phosphate starvation-inducible protein PhoH
H7696_12790	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H7696_12795	COG4535	Mg2 and Co2 transporter CorC
H7696_12800	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H7696_12805	COG2888	peptidyl-tyrosine sulfation
H7696_12810	COG0495	leucyl-tRNA aminoacylation
H7696_12815	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
H7696_12820	COG1466	dna polymerase III delta subunit
H7696_12825	COG0799	negative regulation of ribosome biogenesis
H7696_12830	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H7696_12835	COG0768	penicillin binding
H7696_12840	COG0772	Belongs to the SEDS family
H7696_12845	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H7696_12850	COG1686	Belongs to the peptidase S11 family
H7696_12860	COG0321	lipoyl(octanoyl) transferase activity
H7696_12865	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H7696_12870	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H7696_12875	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H7696_12890	COG0366	Alpha amylase catalytic
H7696_12895	COG1263	PTS System
H7696_12895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7696_12905	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H7696_12910	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H7696_12915	COG2011	ABC-type metal ion transport system permease component
H7696_12920	COG1464	Belongs to the NlpA lipoprotein family
H7696_12925	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
H7696_12935	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H7696_12935	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H7696_12950	COG1611	Belongs to the LOG family
H7696_12955	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7696_12965	COG2363	Small membrane protein
H7696_12975	COG0583	DNA-binding transcription factor activity
H7696_12980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7696_12980	COG0301	tRNA thio-modification
H7696_12990	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7696_12995	COG1722	exodeoxyribonuclease VII activity
H7696_13000	COG0142	geranyltranstransferase activity
H7696_13005	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H7696_13010	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H7696_13015	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H7696_13025	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H7696_13040	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7696_13040	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7696_13045	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H7696_13050	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H7696_13055	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H7696_13065	COG1073	alpha beta
H7696_13070	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H7696_13075	COG2252	PERMEase
H7696_13080	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7696_13095	COG1629	transport
H7696_13110	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H7696_13110	COG0047	phosphoribosylformylglycinamidine synthase activity
H7696_13115	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H7696_13125	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H7696_13155	COG0484	heat shock protein binding
H7696_13165	COG1301	dicarboxylic acid transport
H7696_13170	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H7696_13175	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H7696_13185	COG0497	DNA recombination
H7696_13195	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7696_13200	COG2914	Belongs to the UPF0125 (RnfH) family
H7696_13205	COG2867	negative regulation of translational initiation
H7696_13210	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H7696_13230	COG0583	DNA-binding transcription factor activity
H7696_13235	COG3153	acetyltransferase
H7696_13235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7696_13255	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7696_13260	COG2873	o-acetylhomoserine
H7696_13275	COG1115	amino acid carrier protein
H7696_13280	COG1584	GPR1 FUN34 yaaH family protein
H7696_13290	COG1757	Na H antiporter
H7696_13295	COG0519	Catalyzes the synthesis of GMP from XMP
H7696_13295	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7696_13300	COG0517	IMP dehydrogenase activity
H7696_13300	COG0516	GMP reductase activity
H7696_13320	COG1160	GTP binding
H7696_13325	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7696_13330	COG2976	Protein conserved in bacteria
H7696_13335	COG0124	histidyl-tRNA synthetase
H7696_13340	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H7696_13355	COG0105	UTP biosynthetic process
H7696_13365	COG2975	iron-sulfur cluster assembly
H7696_13370	COG0633	Ferredoxin
H7696_13375	COG0443	Heat shock 70 kDa protein
H7696_13390	COG0822	iron-sulfur transferase activity
H7696_13395	COG1104	cysteine desulfurase activity
H7696_13405	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H7696_13410	COG0483	inositol monophosphate 1-phosphatase activity
H7696_13415	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7696_13420	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7696_13425	COG1862	Preprotein translocase
H7696_13435	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H7696_13445	COG0517	IMP dehydrogenase activity
H7696_13455	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H7696_13460	COG0583	DNA-binding transcription factor activity
H7696_13465	COG0450	alkyl hydroperoxide reductase
H7696_13470	COG3142	Participates in the control of copper homeostasis
H7696_13480	COG0704	Plays a role in the regulation of phosphate uptake
H7696_13485	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H7696_13490	COG0581	inorganic phosphate transmembrane transporter activity
H7696_13495	COG0573	inorganic phosphate transmembrane transporter activity
H7696_13500	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H7696_13505	COG0248	Ppx GppA phosphatase
H7696_13515	COG5002	protein histidine kinase activity
H7696_13520	COG0745	RESPONSE REGULATOR receiver
H7696_13525	COG2974	May be involved in recombination
H7696_13530	COG0826	peptidase U32
H7696_13535	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7696_13590	COG0542	response to heat
H7696_13600	COG0564	pseudouridine synthase activity
H7696_13605	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7696_13615	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H7696_13620	COG0077	Prephenate dehydratase
H7696_13620	COG1605	Chorismate mutase
H7696_13625	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
H7696_13630	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
H7696_13640	COG0488	(ABC) transporter
H7696_13650	COG0739	heme binding
H7696_13655	COG0287	Prephenate dehydrogenase
H7696_13655	COG1605	Chorismate mutase
H7696_13660	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7696_13665	COG1472	Belongs to the glycosyl hydrolase 3 family
H7696_13670	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H7696_13690	COG1966	Carbon starvation protein
H7696_13695	COG3275	phosphorelay sensor kinase activity
H7696_13700	COG3279	Response regulator of the LytR AlgR family
H7696_13710	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H7696_13715	COG1047	Peptidyl-prolyl cis-trans
H7696_13730	COG0196	riboflavin kinase activity
H7696_13735	COG0728	peptidoglycan biosynthetic process
H7696_13740	COG0268	Binds directly to 16S ribosomal RNA
H7696_13745	COG0640	Transcriptional regulator
H7696_13750	COG0583	DNA-binding transcription factor activity
H7696_13755	COG1283	sodium-dependent phosphate transmembrane transporter activity
H7696_13765	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H7696_13770	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H7696_13775	COG0730	response to heat
H7696_13800	COG0667	Aldo Keto reductase
H7696_13810	COG2204	response regulator
H7696_13825	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H7696_13830	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7696_13835	COG4974	Belongs to the 'phage' integrase family
H7696_13840	COG0716	FMN binding
H7696_13850	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H7696_13855	COG0513	Belongs to the DEAD box helicase family
H7696_13860	COG3022	response to hydroperoxide
H7696_13865	COG1115	amino acid carrier protein
H7696_13880	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H7696_13885	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H7696_13890	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
H7696_13895	COG0431	NADPH-dependent FMN reductase
H7696_13900	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7696_13905	COG0083	homoserine kinase activity
H7696_13925	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7696_13935	COG0745	RESPONSE REGULATOR receiver
H7696_13945	COG0784	Response regulator, receiver
H7696_13945	COG2198	Histidine kinase
H7696_13945	COG5002	protein histidine kinase activity
H7696_13950	COG3706	GGDEF domain
H7696_13950	COG4251	negative regulation of phosphorylation
H7696_13950	COG5001	Diguanylate cyclase
H7696_13950	COG2203	Gaf domain
H7696_13955	COG1242	4 iron, 4 sulfur cluster binding
H7696_13960	COG0069	glutamate synthase activity
H7696_13960	COG0067	glutamate synthase
H7696_13960	COG0070	glutamate synthase
H7696_13970	COG0069	glutamate synthase activity
H7696_13970	COG0070	glutamate synthase
H7696_13970	COG0067	glutamate synthase
H7696_13975	COG0493	'glutamate synthase
H7696_13985	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H7696_14000	COG2860	membrane
H7696_14005	COG0583	DNA-binding transcription factor activity
H7696_14010	COG0730	response to heat
H7696_14025	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H7696_14030	COG0505	Belongs to the CarA family
H7696_14040	COG0494	nUDIX hydrolase
H7696_14045	COG0653	protein targeting
H7696_14055	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H7696_14060	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H7696_14065	COG0849	cell division
H7696_14070	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H7696_14085	COG0772	Belongs to the SEDS family
H7696_14090	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H7696_14095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H7696_14100	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H7696_14105	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H7696_14110	COG0768	penicillin binding
H7696_14115	COG3116	cell division
H7696_14130	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H7696_14145	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H7696_14150	COG2823	Periplasmic or secreted lipoprotein
H7696_14155	COG2969	positive regulation of protein catabolic process
H7696_14160	COG0625	glutathione transferase activity
H7696_14165	COG2857	Cytochrome c1
H7696_14170	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H7696_14175	COG0723	plastoquinol--plastocyanin reductase activity
H7696_14180	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H7696_14190	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H7696_14195	COG3105	Protein conserved in bacteria
H7696_14205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7696_14210	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H7696_14220	COG3150	esterase
H7696_14230	COG3151	Protein conserved in bacteria
H7696_14235	COG0494	nUDIX hydrolase
H7696_14240	COG1538	Outer membrane efflux protein
H7696_14245	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H7696_14245	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H7696_14250	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H7696_14265	COG3025	triphosphatase activity
H7696_14270	COG1392	Phosphate transport regulator
H7696_14275	COG0306	phosphate transporter
H7696_14280	COG4991	sh3 domain protein
H7696_14285	COG0405	Gamma-glutamyltransferase
H7696_14295	COG3267	Type II secretory pathway component ExeA
H7696_14295	COG3409	Peptidoglycan-binding domain 1 protein
H7696_14305	COG1968	undecaprenyl-diphosphatase activity
H7696_14310	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H7696_14315	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H7696_14320	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H7696_14325	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7696_14330	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H7696_14335	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H7696_14340	COG1610	YqeY-like protein
H7696_14345	COG0358	DNA primase activity
H7696_14380	COG2213	PTS system mannitol-specific
H7696_14380	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7696_14390	COG3722	fumarate hydratase activity
H7696_14405	COG1461	Dihydroxyacetone kinase
H7696_14410	COG2376	Dihydroxyacetone kinase
H7696_14420	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H7696_14425	COG1349	DNA-binding transcription factor activity
H7696_14430	COG0469	pyruvate kinase activity
H7696_14445	COG0440	acetolactate synthase activity
H7696_14450	COG0028	Belongs to the TPP enzyme family
H7696_14455	COG1022	Amp-dependent synthetase and ligase
H7696_14460	COG0583	DNA-binding transcription factor activity
H7696_14480	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7696_14485	COG0473	3-isopropylmalate dehydrogenase activity
H7696_14505	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H7696_14510	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H7696_14515	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7696_14520	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H7696_14525	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H7696_14530	COG2967	ApaG domain
H7696_14535	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H7696_14550	COG2966	Psort location CytoplasmicMembrane, score
H7696_14555	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H7696_14565	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H7696_14570	COG0142	geranyltranstransferase activity
H7696_14590	COG2358	TRAP transporter, solute receptor (TAXI family
H7696_14605	COG1902	pentaerythritol trinitrate reductase activity
H7696_14610	COG0583	DNA-binding transcription factor activity
H7696_14615	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
H7696_14620	COG1178	ABC-type Fe3 transport system permease component
H7696_14630	COG0163	prenyltransferase activity
H7696_14635	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7696_14640	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H7696_14645	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H7696_14655	COG2105	PFAM AIG2 family protein
H7696_14660	COG2911	Protein conserved in bacteria
H7696_14665	COG0729	surface antigen
H7696_14670	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7696_14680	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H7696_14695	COG4181	ATPase activity
H7696_14715	COG0529	Catalyzes the synthesis of activated sulfate
H7696_14720	COG3273	potassium ion transport
H7696_14720	COG0471	metal ion transport
H7696_14725	COG2895	sulfate adenylyltransferase (ATP) activity
H7696_14730	COG0175	sulfate reduction
H7696_14735	COG1648	precorrin-2 dehydrogenase activity
H7696_14735	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7696_14740	COG0737	Belongs to the 5'-nucleotidase family
H7696_14750	COG0513	Belongs to the DEAD box helicase family
H7696_14755	COG2153	protein acetylation
H7696_14765	COG0545	Peptidyl-prolyl cis-trans isomerase
H7696_14775	COG0203	ribosomal protein L17
H7696_14780	COG0202	RNA polymerase activity
H7696_14790	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H7696_14795	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H7696_14800	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H7696_14805	COG0201	protein transport
H7696_14810	COG0200	Binds to the 23S rRNA
H7696_14815	COG1841	ribosomal large subunit assembly
H7696_14830	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H7696_14835	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H7696_14845	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H7696_14850	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H7696_14860	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H7696_14865	COG0255	Belongs to the universal ribosomal protein uL29 family
H7696_14875	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H7696_14880	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H7696_14885	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H7696_14890	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H7696_14900	COG0088	Forms part of the polypeptide exit tunnel
H7696_14905	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H7696_14915	COG0254	rRNA binding
H7696_14920	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H7696_14925	COG1609	Transcriptional regulator
H7696_14935	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H7696_14940	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H7696_14945	COG1575	Belongs to the MenA family. Type 1 subfamily
H7696_14950	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7696_14960	COG1494	fructose-1,6-bisphosphatase
H7696_14990	COG0149	triose-phosphate isomerase activity
H7696_15045	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H7696_15045	COG2755	lipolytic protein G-D-S-L family
H7696_15055	COG0463	Glycosyl transferase, family 2
H7696_15080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H7696_15090	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H7696_15100	COG1215	transferase activity, transferring glycosyl groups
H7696_15110	COG0438	transferase activity, transferring glycosyl groups
H7696_15160	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7696_15170	COG1560	Kdo2-lipid A biosynthetic process
H7696_15180	COG0859	PFAM glycosyl transferase family 9
H7696_15185	COG1519	Transferase
H7696_15195	COG2089	acid synthase
H7696_15205	COG1083	cytidylyl-transferase
H7696_15210	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7696_15215	COG1086	Polysaccharide biosynthesis protein
H7696_15220	COG3642	lipopolysaccharide core region biosynthetic process
H7696_15225	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H7696_15230	COG0859	PFAM glycosyl transferase family 9
H7696_15235	COG0463	Glycosyl transferase, family 2
H7696_15250	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H7696_15275	COG2003	Belongs to the UPF0758 family
H7696_15285	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H7696_15290	COG1309	transcriptional regulator
H7696_15295	COG1560	Kdo2-lipid A biosynthetic process
H7696_15300	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H7696_15305	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H7696_15310	COG1561	YicC-like family, N-terminal region
H7696_15320	COG4608	Belongs to the ABC transporter superfamily
H7696_15325	COG0444	Belongs to the ABC transporter superfamily
H7696_15330	COG0747	negative chemotaxis
H7696_15335	COG4239	(ABC) transporter, permease
H7696_15340	COG4174	ABC transporter (Permease)
H7696_15360	COG0811	peptide transport
H7696_15365	COG0848	biopolymer transport protein
H7696_15380	COG0194	GDP metabolic process
H7696_15385	COG1758	RNA polymerase activity
H7696_15390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7696_15395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7696_15400	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H7696_15405	COG2233	PERMEase
H7696_15425	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7696_15435	COG2183	response to ionizing radiation
H7696_15450	COG1040	competence protein
H7696_15460	COG0494	nUDIX hydrolase
H7696_15465	COG1218	3'(2'),5'-bisphosphate nucleotidase
H7696_15475	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
H7696_15480	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
H7696_15485	COG3156	type II secretion system protein K
H7696_15490	COG4795	General secretion pathway protein
H7696_15495	COG2165	general secretion pathway protein
H7696_15500	COG2165	general secretion pathway protein
H7696_15505	COG2165	general secretion pathway protein
H7696_15510	COG1459	type II secretion system
H7696_15515	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7696_15525	COG3031	protein transport across the cell outer membrane
H7696_15530	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H7696_15535	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H7696_15540	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H7696_15550	COG0456	acetyltransferase
H7696_15555	COG1490	D-aminoacyl-tRNA deacylase activity
H7696_15560	COG1295	ribonuclease BN
H7696_15570	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H7696_15575	COG1217	gtp-binding protein TYPA
H7696_15580	COG0174	glutamine synthetase
H7696_15590	COG3852	Histidine kinase
H7696_15595	COG2204	response regulator
H7696_15605	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H7696_15635	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H7696_15640	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7696_15640	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7696_15645	COG0456	acetyltransferase
H7696_15655	COG0084	hydrolase, TatD family'
H7696_15660	COG0805	protein transport
H7696_15665	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7696_15675	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H7696_15680	COG3165	ubiquinone biosynthetic process from chorismate
H7696_15685	COG2226	methyltransferase
H7696_15690	COG1322	Protein conserved in bacteria
H7696_15705	COG0628	permease
H7696_15735	COG1597	lipid kinase activity
H7696_15765	COG2081	HI0933 family
H7696_15775	COG1528	Iron-storage protein
H7696_15780	COG0589	response to stress
H7696_15800	COG5001	Diguanylate cyclase
H7696_15800	COG5002	protein histidine kinase activity
H7696_15805	COG1522	sequence-specific DNA binding
H7696_15815	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H7696_15820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7696_15850	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H7696_15855	COG0583	DNA-binding transcription factor activity
H7696_15860	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H7696_15865	COG0800	Aldolase
H7696_15870	COG2610	gluconate transmembrane transporter activity
H7696_15875	COG3265	gluconokinase activity
H7696_15880	COG0129	dihydroxy-acid dehydratase activity
H7696_15895	COG0583	DNA-binding transcription factor activity
H7696_15900	COG1609	Transcriptional regulator
H7696_15935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7696_15940	COG0601	transmembrane transport
H7696_15945	COG4166	transmembrane transport
H7696_16000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7696_16005	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7696_16010	COG2960	long-chain fatty acid transporting porin activity
H7696_16015	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H7696_16020	COG0583	DNA-binding transcription factor activity
H7696_16055	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H7696_16070	COG0408	coproporphyrinogen oxidase activity
H7696_16075	COG0009	L-threonylcarbamoyladenylate synthase
H7696_16080	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H7696_16085	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H7696_16090	COG0551	DNA topoisomerase type I activity
H7696_16095	COG2922	Belongs to the Smg family
H7696_16100	COG0758	DNA mediated transformation
H7696_16110	COG0242	peptide deformylase activity
H7696_16115	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H7696_16120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7696_16120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7696_16125	COG0569	domain protein
H7696_16130	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7696_16140	COG1272	protein, Hemolysin III
H7696_16145	COG4326	sporulation control protein
H7696_16155	COG3084	Protein conserved in bacteria
H7696_16165	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H7696_16170	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7696_16175	COG0204	Acyl-transferase
H7696_16185	COG0606	chelatase, subunit chli
H7696_16195	COG3978	acetolactate synthase activity
H7696_16200	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7696_16205	COG0129	dihydroxy-acid dehydratase activity
H7696_16215	COG0583	DNA-binding transcription factor activity
H7696_16220	COG2814	Major facilitator Superfamily
H7696_16230	COG0765	amino acid transport
H7696_16240	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H7696_16245	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H7696_16250	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H7696_16255	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H7696_16260	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H7696_16265	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H7696_16275	COG0356	it plays a direct role in the translocation of protons across the membrane
H7696_16280	COG3312	ion transport
H7696_16285	COG1475	DNA binding
H7696_16290	COG1192	Involved in chromosome partitioning
H7696_16295	COG0357	Ribosomal RNA small subunit methyltransferase G
H7696_16300	COG0445	tRNA wobble uridine modification
H7696_16305	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7696_16315	COG0706	membrane insertase activity
H7696_16325	COG0594	ribonuclease P activity
H7696_16335	COG1126	abc transporter atp-binding protein
H7696_16350	COG3069	C4-dicarboxylate transmembrane transporter activity
H7696_16375	COG3111	PFAM Bacterial OB fold (BOF) protein
H7696_16380	COG1597	lipid kinase activity
H7696_16385	COG0583	DNA-binding transcription factor activity
H7696_16390	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7696_16420	COG0714	Associated with various cellular activities
H7696_16425	COG0641	radical SAM
H7696_16430	COG3119	arylsulfatase activity
H7696_16440	COG3119	arylsulfatase activity
H7696_16445	COG0745	RESPONSE REGULATOR receiver
H7696_16460	COG0784	Response regulator, receiver
H7696_16460	COG2205	protein histidine kinase activity
H7696_16460	COG2198	Histidine kinase
H7696_16465	COG1879	ABC-type sugar transport system periplasmic component
H7696_16470	COG1803	Methylglyoxal synthase
H7696_16475	COG0210	DNA helicase
H7696_16480	COG1289	transmembrane transporter activity
H7696_16510	COG4771	TonB-dependent receptor
H7696_16510	COG1629	transport
H7696_16520	COG0789	Transcriptional regulator
H7696_16525	COG4604	ABC transporter, ATP-binding protein
H7696_16530	COG4605	iron ion homeostasis
H7696_16535	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7696_16540	COG4607	ABC-type enterochelin transport system periplasmic component
H7696_16550	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
H7696_16560	COG1609	Transcriptional regulator
H7696_16565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7696_16570	COG1879	ABC-type sugar transport system periplasmic component
H7696_16575	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7696_16580	COG1129	ABC transporter
H7696_16585	COG1869	D-ribose catabolic process
H7696_16590	COG5001	Diguanylate cyclase
H7696_16645	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H7696_16655	COG0784	Response regulator, receiver
H7696_16655	COG2205	protein histidine kinase activity
H7696_16670	COG0330	HflC and HflK could
H7696_16685	COG0517	IMP dehydrogenase activity
H7696_16685	COG4175	Glycine betaine
H7696_16690	COG4176	ABC-type proline glycine betaine transport system permease component
H7696_16705	COG1012	belongs to the aldehyde dehydrogenase family
H7696_16710	COG1309	transcriptional regulator
H7696_16720	COG1028	Short-chain dehydrogenase reductase Sdr
H7696_16735	COG1024	Enoyl-CoA hydratase
H7696_16740	COG1960	acyl-CoA dehydrogenase activity
H7696_16750	COG0183	Belongs to the thiolase family
H7696_16760	COG1960	acyl-CoA dehydrogenase activity
H7696_16765	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7696_16775	COG4770	biotin carboxylase activity
H7696_16790	COG3264	Mechanosensitive ion channel
H7696_16790	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H7696_16795	COG0110	maltose O-acetyltransferase activity
H7696_16800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7696_16805	COG1271	oxidase subunit
H7696_16810	COG1294	oxidase, subunit
H7696_16820	COG0384	phenazine biosynthesis protein PhzF
H7696_16830	COG3527	Alpha-acetolactate decarboxylase
H7696_16840	COG1028	Short-chain dehydrogenase reductase Sdr
H7696_16845	COG0500	methyltransferase
H7696_16875	COG1022	Amp-dependent synthetase and ligase
H7696_16900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7696_16905	COG1263	PTS System
H7696_16905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7696_16910	COG1486	melibiose metabolic process
H7696_16915	COG2188	Transcriptional regulator
H7696_16920	COG1320	monovalent cation:proton antiporter activity
H7696_16925	COG2212	antiporter activity
H7696_16930	COG1863	multisubunit Na H antiporter MnhE subunit
H7696_16935	COG0651	ATP synthesis coupled electron transport
H7696_16940	COG1006	Multisubunit Na H antiporter MnhC subunit
H7696_16945	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H7696_16945	COG2111	Na H antiporter
H7696_16955	COG0589	response to stress
H7696_16960	COG4221	oxidoreductase activity
H7696_16965	COG0583	DNA-binding transcription factor activity
H7696_16975	COG2814	Major facilitator Superfamily
H7696_16995	COG3501	Rhs element vgr protein
H7696_16995	COG3409	Peptidoglycan-binding domain 1 protein
H7696_17040	COG1522	sequence-specific DNA binding
H7696_17075	COG0515	serine threonine protein kinase
H7696_17100	COG3501	Rhs element vgr protein
H7696_17140	COG0739	heme binding
H7696_17150	COG1120	ATPase activity
H7696_17155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7696_17160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7696_17185	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H7696_17185	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H7696_17200	COG4989	oxidoreductase activity
H7696_17215	COG0038	chloride channel
H7696_17235	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7696_17250	COG2897	thiosulfate sulfurtransferase activity
H7696_17260	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7696_17265	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H7696_17270	COG0840	transmembrane signaling receptor activity
H7696_17275	COG2814	Major facilitator Superfamily
H7696_17280	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7696_17295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7696_17305	COG0840	transmembrane signaling receptor activity
H7696_17325	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7696_17340	COG2197	response regulator
H7696_17345	COG3850	Histidine kinase
H7696_17350	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7696_17360	COG0243	molybdopterin cofactor binding
H7696_17370	COG3005	denitrification pathway
H7696_17380	COG3243	poly(R)-hydroxyalkanoic acid synthase
H7696_17390	COG0183	Belongs to the thiolase family
H7696_17400	COG1280	lysine exporter protein (LysE YggA)
H7696_17410	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7696_17415	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7696_17465	COG1846	Transcriptional regulator
H7696_17470	COG0784	Response regulator, receiver
H7696_17470	COG2205	protein histidine kinase activity
H7696_17475	COG1879	ABC-type sugar transport system periplasmic component
H7696_17480	COG2827	Endonuclease containing a URI domain
H7696_17485	COG3132	Protein of unknown function, DUF480
H7696_17505	COG5002	protein histidine kinase activity
H7696_17505	COG2205	protein histidine kinase activity
H7696_17505	COG0784	Response regulator, receiver
H7696_17530	COG0583	DNA-binding transcription factor activity
H7696_17540	COG0531	amino acid
H7696_17555	COG2205	protein histidine kinase activity
H7696_17560	COG0745	RESPONSE REGULATOR receiver
H7696_17590	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H7696_17595	COG2239	Acts as a magnesium transporter
H7696_17600	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H7696_17605	COG0402	S-adenosylhomocysteine deaminase activity
H7696_17610	COG1418	mRNA catabolic process
H7696_17620	COG2814	Major facilitator Superfamily
H7696_17630	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7696_17650	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7696_17665	COG0745	RESPONSE REGULATOR receiver
H7696_17670	COG2205	protein histidine kinase activity
H7696_17680	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H7696_17685	COG2194	sulfuric ester hydrolase activity
H7696_17705	COG4667	esterase of the alpha-beta hydrolase superfamily
H7696_17710	COG1741	Belongs to the pirin family
H7696_17715	COG1278	Cold shock
H7696_17730	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H7696_17735	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H7696_17735	COG0678	peroxiredoxin activity
H7696_17745	COG1686	Belongs to the peptidase S11 family
H7696_17750	COG0625	glutathione transferase activity
H7696_17760	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H7696_17765	COG1621	beta-fructofuranosidase activity
H7696_17770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7696_17775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7696_17775	COG1263	PTS System
H7696_17795	COG4771	TonB-dependent receptor
H7696_17800	COG0583	DNA-binding transcription factor activity
H7696_17810	COG1404	Belongs to the peptidase S8 family
H7696_17815	COG1028	Short-chain dehydrogenase reductase Sdr
H7696_17830	COG3746	phosphate-selective porin O and P
H7696_17845	COG0300	oxidoreductase activity
H7696_17850	COG0583	DNA-binding transcription factor activity
H7696_17855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7696_17855	COG2207	Transcriptional regulator
H7696_17860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7696_17880	COG0513	Belongs to the DEAD box helicase family
H7696_17890	COG0583	DNA-binding transcription factor activity
H7696_17905	COG1902	pentaerythritol trinitrate reductase activity
H7696_17910	COG1063	alcohol dehydrogenase
H7696_17920	COG1028	Short-chain dehydrogenase reductase Sdr
H7696_17930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7696_17935	COG0006	proline dipeptidase activity
H7696_17940	COG3608	succinylglutamate desuccinylase aspartoacylase
H7696_17945	COG1522	sequence-specific DNA binding
H7696_17950	COG1012	belongs to the aldehyde dehydrogenase family
H7696_17955	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7696_17960	COG3122	Protein conserved in bacteria
H7696_17975	COG0583	DNA-binding transcription factor activity
H7696_17980	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H7696_17985	COG0252	asparaginase activity
H7696_17990	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H7696_18005	COG2197	response regulator
H7696_18010	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H7696_18035	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H7696_18065	COG3842	ATPase activity
H7696_18085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7696_18115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7696_18150	COG0583	DNA-binding transcription factor activity
H7696_18160	COG4948	Mandelate Racemase Muconate Lactonizing
H7696_18190	COG1342	Belongs to the UPF0251 family
H7696_18195	COG4176	ABC-type proline glycine betaine transport system permease component
H7696_18200	COG3448	diguanylate cyclase activity
H7696_18200	COG4175	Glycine betaine
H7696_18205	COG3015	lipoprotein NlpE involved in copper resistance
H7696_18210	COG3713	MltA-interacting MipA family protein
H7696_18225	COG0583	DNA-binding transcription factor activity
H7696_18250	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H7696_18260	COG1335	isochorismatase
H7696_18275	COG1349	DNA-binding transcription factor activity
H7696_18280	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7696_18280	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7696_18285	COG2070	2-Nitropropane dioxygenase
H7696_18290	COG0531	amino acid
H7696_18295	COG4302	ethanolamine ammonia-lyase activity
H7696_18300	COG4303	Ethanolamine ammonia lyase large subunit
H7696_18310	COG1309	transcriptional regulator
H7696_18330	COG1280	lysine exporter protein (LysE YggA)
H7696_18340	COG0459	protein refolding
H7696_18345	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H7696_18350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7696_18365	COG1304	FMN binding
H7696_18390	COG1256	bacterial-type flagellum assembly
H7696_18390	COG4786	Flagellar basal body rod
H7696_18400	COG1706	bacterial-type flagellum-dependent cell motility
H7696_18405	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H7696_18410	COG4786	Flagellar basal body rod
H7696_18415	COG4787	bacterial-type flagellum-dependent cell motility
H7696_18425	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H7696_18430	COG1558	bacterial-type flagellum-dependent cell motility
H7696_18435	COG1815	bacterial-type flagellum-dependent cell motility
H7696_18455	COG1388	LysM domain
H7696_18455	COG0741	lytic transglycosylase activity
H7696_18460	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H7696_18480	COG1760	l-serine dehydratase
H7696_18495	COG0583	DNA-binding transcription factor activity
H7696_18505	COG2866	Carboxypeptidase
H7696_18510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7696_18520	COG2990	Protein conserved in bacteria
H7696_18545	COG3842	ATPase activity
H7696_18550	COG1840	ABC-type Fe3 transport system, periplasmic component
H7696_18560	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H7696_18570	COG1609	Transcriptional regulator
H7696_18600	COG3240	lipase activity
H7696_18605	COG1309	transcriptional regulator
H7696_18620	COG1136	(ABC) transporter
H7696_18620	COG0577	efflux transmembrane transporter activity
H7696_18625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7696_18630	COG2067	long-chain fatty acid transport protein
H7696_18640	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H7696_18655	COG1011	Hydrolase
H7696_18695	COG0110	maltose O-acetyltransferase activity
H7696_18700	COG1765	OsmC-like protein
H7696_18705	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7696_18705	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7696_18720	COG3046	protein related to deoxyribodipyrimidine photolyase
H7696_18725	COG0415	Belongs to the DNA photolyase family
H7696_18730	COG3706	GGDEF domain
H7696_18745	COG3706	GGDEF domain
H7696_18760	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7696_18775	COG3033	Beta-eliminating lyase
H7696_18785	COG1271	oxidase subunit
H7696_18790	COG1294	oxidase, subunit
H7696_18800	COG0579	oxidoreductase
H7696_18820	COG3706	GGDEF domain
H7696_18830	COG4191	Histidine kinase
H7696_18850	COG0583	DNA-binding transcription factor activity
H7696_18870	COG0189	ligase activity
H7696_18875	COG0189	ligase activity
H7696_18875	COG4067	protein conserved in archaea
H7696_18885	COG1166	arginine decarboxylase activity
H7696_18895	COG2814	Major facilitator Superfamily
H7696_18900	COG1770	oligopeptidase
H7696_18915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H7696_18920	COG1121	(ABC) transporter
H7696_18925	COG0803	Belongs to the bacterial solute-binding protein 9 family
H7696_18965	COG0848	biopolymer transport protein
H7696_18970	COG0811	peptide transport
H7696_18975	COG0811	peptide transport
H7696_18995	COG0745	RESPONSE REGULATOR receiver
H7696_19010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7696_19070	COG1901	pseudouridine methyltransferase
H7696_19075	COG0312	modulator of DNA gyrase
H7696_19080	COG0312	modulator of DNA gyrase
H7696_19085	COG0351	phosphomethylpyrimidine kinase
H7696_19090	COG1116	anion transmembrane transporter activity
H7696_19095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7696_19100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7696_19105	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H7696_19110	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
H7696_19125	COG0243	molybdopterin cofactor binding
H7696_19130	COG3005	denitrification pathway
H7696_19135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7696_19140	COG1028	Short-chain dehydrogenase reductase Sdr
H7696_19155	COG0456	acetyltransferase
H7696_19175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7696_19180	COG1929	Belongs to the glycerate kinase type-1 family
H7696_19185	COG2610	gluconate transmembrane transporter activity
H7696_19190	COG3835	regulator
H7696_19250	COG3047	cAMP biosynthetic process
H7696_19255	COG1357	PFAM Pentapeptide repeats (8 copies)
H7696_19285	COG2375	cellular response to nickel ion
H7696_19290	COG0583	DNA-binding transcription factor activity
H7696_19295	COG2162	N-hydroxyarylamine O-acetyltransferase activity
H7696_19300	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H7696_19315	COG2199	diguanylate cyclase activity
H7696_19325	COG0561	phosphatase activity
H7696_19330	COG0583	DNA-binding transcription factor activity
H7696_19345	COG0564	pseudouridine synthase activity
H7696_19350	COG0534	Mate efflux family protein
H7696_19355	COG5001	Diguanylate cyclase
H7696_19365	COG3123	guanosine phosphorylase activity
H7696_19380	COG0596	Alpha beta hydrolase
H7696_19405	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H7696_19415	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H7696_19420	COG2169	Transcriptional regulator
H7696_19420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H7696_19430	COG2259	Doxx family
H7696_19435	COG1741	Belongs to the pirin family
H7696_19455	COG0363	glucosamine-6-phosphate deaminase activity
H7696_19465	COG0786	glutamate:sodium symporter activity
H7696_19470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7696_19475	COG1131	(ABC) transporter
H7696_19485	COG0786	glutamate:sodium symporter activity
H7696_19505	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H7696_19515	COG3279	Response regulator of the LytR AlgR family
H7696_19520	COG3275	phosphorelay sensor kinase activity
H7696_19550	COG0772	Belongs to the SEDS family
H7696_19575	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
H7696_19575	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7696_19585	COG0444	Belongs to the ABC transporter superfamily
H7696_19590	COG4608	Belongs to the ABC transporter superfamily
H7696_19615	COG1444	tRNA N-acetyltransferase activity
H7696_19635	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H7696_19640	COG1263	PTS System
H7696_19640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7696_19645	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H7696_19660	COG4166	transmembrane transport
H7696_19710	COG0259	pyridoxamine-phosphate oxidase activity
H7696_19735	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7696_19770	COG1132	(ABC) transporter
H7696_19780	COG0513	Belongs to the DEAD box helicase family
H7696_19785	COG2258	MOSC domain
H7696_19830	COG3634	alkyl hydroperoxide reductase activity
H7696_19840	COG1846	Transcriptional regulator
H7696_19845	COG1764	response to oxidative stress
H7696_19880	COG0577	efflux transmembrane transporter activity
H7696_19885	COG1136	(ABC) transporter
H7696_19895	COG0826	peptidase U32
H7696_19920	COG1653	transport
H7696_19925	COG0019	diaminopimelate decarboxylase activity
H7696_19930	COG4264	IucA IucC family
H7696_19955	COG4772	TonB-dependent receptor
H7696_19960	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H7696_19965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7696_19970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7696_19975	COG1120	ATPase activity
H7696_19980	COG0840	transmembrane signaling receptor activity
H7696_19985	COG0612	Peptidase, M16
H7696_19995	COG0739	heme binding
H7696_20010	COG2814	Major facilitator Superfamily
H7696_20020	COG1609	Transcriptional regulator
H7696_20025	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7696_20040	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H7696_20040	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H7696_20050	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H7696_20055	COG1609	Transcriptional regulator
H7696_20065	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H7696_20105	COG1760	l-serine dehydratase
H7696_20115	COG4580	involved in the transport of maltose and maltodextrins
H7696_20135	COG2356	endonuclease I
H7696_20155	COG1982	Orn Lys Arg decarboxylase major
H7696_20160	COG0531	amino acid
H7696_20170	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H7696_20175	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H7696_20180	COG1162	GTPase activity
H7696_20185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7696_20185	COG1263	PTS System
H7696_20190	COG1999	signal sequence binding
H7696_20205	COG2909	trisaccharide binding
H7696_20210	COG0058	SHG alpha-glucan phosphorylase activity
H7696_20215	COG1640	4-alpha-glucanotransferase
H7696_20220	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H7696_20225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7696_20230	COG0366	Alpha amylase catalytic
H7696_20245	COG3366	ferrous iron transmembrane transporter activity
H7696_20250	COG0700	Nucleoside recognition
H7696_20255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7696_20260	COG3339	Conserved Protein
H7696_20265	COG1301	dicarboxylic acid transport
H7696_20275	COG0583	DNA-binding transcription factor activity
H7696_20295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H7696_20300	COG1596	polysaccharide export
H7696_20315	COG2095	MarC family integral membrane protein
H7696_20320	COG4667	esterase of the alpha-beta hydrolase superfamily
H7696_20325	COG3397	chitin binding
H7696_20330	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H7696_20335	COG0415	Belongs to the DNA photolyase family
H7696_20345	COG1054	Belongs to the UPF0176 family
H7696_20355	COG1686	Belongs to the peptidase S11 family
H7696_20380	COG0583	DNA-binding transcription factor activity
H7696_20385	COG4628	conserved protein (DUF2132)
H7696_20405	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H7696_20410	COG0628	permease
H7696_20450	COG2814	Major facilitator Superfamily
H7696_20460	COG0454	-acetyltransferase
H7696_20470	COG0745	RESPONSE REGULATOR receiver
H7696_20475	COG2205	protein histidine kinase activity
H7696_20490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7696_20495	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7696_20500	COG1882	Formate acetyltransferase
H7696_20530	COG1360	Flagellar Motor Protein
H7696_20535	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7696_20540	COG1191	sigma factor activity
H7696_20545	COG1580	Controls the rotational direction of flagella during chemotaxis
H7696_20560	COG1516	flagellar protein fliS
H7696_20565	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H7696_20570	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7696_20585	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H7696_20595	COG1987	bacterial-type flagellum assembly
H7696_20635	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7696_20695	COG0346	lactoylglutathione lyase activity
H7696_20720	COG0745	RESPONSE REGULATOR receiver
H7696_20745	COG3300	MHYT domain
H7696_20745	COG5001	Diguanylate cyclase
H7696_20750	COG0156	8-amino-7-oxononanoate synthase activity
H7696_20755	COG1063	alcohol dehydrogenase
H7696_20790	COG0668	transmembrane transport
H7696_20800	COG1304	FMN binding
H7696_20805	COG1620	l-lactate permease
H7696_20810	COG0583	DNA-binding transcription factor activity
H7696_20815	COG1505	serine-type exopeptidase activity
H7696_20820	COG4172	Belongs to the ABC transporter superfamily
H7696_20830	COG1067	ATP-dependent peptidase activity
H7696_20840	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H7696_20860	COG1247	-acetyltransferase
H7696_20865	COG0437	4 iron, 4 sulfur cluster binding
H7696_20870	COG0348	domain, Protein
H7696_20890	COG1122	ATPase activity
H7696_20895	COG4720	Psort location CytoplasmicMembrane, score
H7696_20900	COG1566	PFAM secretion protein HlyD family protein
H7696_20925	COG0813	purine-nucleoside phosphorylase activity
H7696_20930	COG3272	Protein of unknown function (DUF1722)
H7696_20935	COG0789	Transcriptional regulator
H7696_20940	COG0415	Belongs to the DNA photolyase family
H7696_20945	COG1388	LysM domain
H7696_20945	COG1376	ErfK ybiS ycfS ynhG family protein
H7696_20955	COG0513	Belongs to the DEAD box helicase family
H7696_20960	COG1770	oligopeptidase
H7696_20965	COG4771	TonB-dependent receptor
H7696_20995	COG0573	inorganic phosphate transmembrane transporter activity
H7696_21000	COG0581	inorganic phosphate transmembrane transporter activity
H7696_21005	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H7696_21020	COG2304	oxidoreductase activity
H7696_21040	COG0714	Associated with various cellular activities
H7696_21045	COG0840	transmembrane signaling receptor activity
H7696_21055	COG2197	response regulator
H7696_21090	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H7696_21095	COG1120	ATPase activity
H7696_21100	COG4774	siderophore transport
H7696_21105	COG1132	(ABC) transporter
H7696_21110	COG2205	protein histidine kinase activity
H7696_21110	COG2205	protein histidine kinase activity
H7696_21115	COG0745	RESPONSE REGULATOR receiver
H7696_21120	COG0569	domain protein
H7696_21125	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7696_21130	COG0583	DNA-binding transcription factor activity
H7696_21145	COG1012	belongs to the aldehyde dehydrogenase family
H7696_21150	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7696_21155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7696_21165	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
H7696_21170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7696_21200	COG2084	Dehydrogenase
H7696_21205	COG0753	catalase activity
H7696_21215	COG2130	NADP-dependent
H7696_21220	COG1309	transcriptional regulator
H7696_21225	COG3097	Belongs to the UPF0267 family
H7696_21265	COG0489	protein tyrosine kinase activity
H7696_21265	COG3206	protein involved in exopolysaccharide biosynthesis
H7696_21280	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H7696_21285	COG3842	ATPase activity
H7696_21295	COG1175	transmembrane transport
H7696_21300	COG3833	ABC-type maltose transport systems, permease component
H7696_21330	COG1132	(ABC) transporter
H7696_21330	COG2375	cellular response to nickel ion
H7696_21335	COG4774	siderophore transport
H7696_21340	COG4607	ABC-type enterochelin transport system periplasmic component
H7696_21345	COG4605	iron ion homeostasis
H7696_21350	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7696_21360	COG2354	Protein conserved in bacteria
H7696_21365	COG0418	dihydroorotase activity
H7696_21370	COG0401	homolog of Blt101
H7696_21375	COG3217	Mosc domain protein beta barrel domain protein
H7696_21375	COG0633	Ferredoxin
H7696_21375	COG3217	Mosc domain protein beta barrel domain protein
H7696_21375	COG0633	Ferredoxin
H7696_21385	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H7696_21425	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H7696_21430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7696_21440	COG0848	biopolymer transport protein
H7696_21445	COG0811	peptide transport
H7696_21450	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
H7696_21460	COG3721	Heme iron utilization protein
H7696_21465	COG0748	coenzyme F420 binding
H7696_21475	COG0835	chemotaxis
H7696_21475	COG0784	Response regulator, receiver
H7696_21480	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7696_21485	COG0534	Mate efflux family protein
H7696_21490	COG0444	Belongs to the ABC transporter superfamily
H7696_21495	COG4608	Belongs to the ABC transporter superfamily
H7696_21500	COG0747	negative chemotaxis
H7696_21510	COG1349	DNA-binding transcription factor activity
H7696_21515	COG2084	Dehydrogenase
H7696_21520	COG3395	kinase activity
H7696_21525	COG0235	Class ii aldolase
H7696_21530	COG3622	Belongs to the hyi family
H7696_21535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7696_21540	COG2610	gluconate transmembrane transporter activity
H7696_21560	COG0583	DNA-binding transcription factor activity
H7696_21565	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H7696_21575	COG4934	collagen metabolic process
H7696_21585	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7696_21590	COG0789	Transcriptional regulator
H7696_21595	COG0366	Alpha amylase catalytic
H7696_21615	COG2249	NAD(P)H dehydrogenase (quinone) activity
H7696_21620	COG0589	response to stress
H7696_21625	COG0488	(ABC) transporter
H7696_21630	COG1505	serine-type exopeptidase activity
H7696_21640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7696_21650	COG2067	long-chain fatty acid transport protein
H7696_21660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7696_21685	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7696_21705	COG3383	formate dehydrogenase (NAD+) activity
H7696_21715	COG0842	Transport permease protein
H7696_21720	COG1131	(ABC) transporter
H7696_21735	COG1881	PFAM PEBP family protein
H7696_21745	COG0798	PFAM Bile acid sodium symporter
H7696_21760	COG1733	regulation of RNA biosynthetic process
H7696_21785	COG4989	oxidoreductase activity
H7696_21810	COG0814	amino acid
H7696_21825	COG3314	Sporulation integral membrane protein YlbJ
H7696_21845	COG0739	heme binding
H7696_21850	COG5001	Diguanylate cyclase
H7696_21855	COG0583	DNA-binding transcription factor activity
H7696_21860	COG2814	Major facilitator Superfamily
H7696_21875	COG0697	spore germination
H7696_21890	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7696_21910	COG1280	lysine exporter protein (LysE YggA)
H7696_21920	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7696_21925	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H7696_21930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7696_21935	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H7696_21940	COG1845	cytochrome c oxidase, subunit III
H7696_21960	COG1612	heme a metabolic process
H7696_21965	COG0109	protoheme IX farnesyltransferase activity
H7696_21970	COG0545	Peptidyl-prolyl cis-trans isomerase
H7696_22000	COG1278	Cold shock
H7696_22005	COG3036	rescue of stalled ribosome
H7696_22010	COG2199	diguanylate cyclase activity
H7696_22025	COG1132	(ABC) transporter
H7696_22035	COG1538	Outer membrane efflux protein
H7696_22040	COG2205	protein histidine kinase activity
H7696_22040	COG0784	Response regulator, receiver
H7696_22065	COG0840	transmembrane signaling receptor activity
H7696_22070	COG0783	Belongs to the Dps family
H7696_22080	COG2133	pyrroloquinoline quinone binding
H7696_22085	COG1454	alcohol dehydrogenase
H7696_22090	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
H7696_22115	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7696_22120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7696_22125	COG3186	Phenylalanine-4-hydroxylase
H7696_22150	COG3530	Putative quorum-sensing-regulated virulence factor
H7696_22170	COG0513	Belongs to the DEAD box helicase family
H7696_22175	COG4628	conserved protein (DUF2132)
H7696_22185	COG0133	tryptophan synthase activity
H7696_22190	COG1278	Cold shock
H7696_22210	COG0523	cobalamin synthesis protein
H7696_22215	COG0513	Belongs to the DEAD box helicase family
H7696_22235	COG2200	EAL domain
H7696_22240	COG1119	ATPase activity
H7696_22275	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
H7696_22280	COG0513	Belongs to the DEAD box helicase family
H7696_22290	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H7696_22300	COG1073	alpha beta
H7696_22305	COG1073	alpha beta
H7696_22320	COG0730	response to heat
H7696_22335	COG0735	belongs to the Fur family
H7696_22340	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H7696_22350	COG0523	cobalamin synthesis protein
H7696_22355	COG2988	succinylglutamate desuccinylase activity
H7696_22360	COG0739	heme binding
H7696_22365	COG0523	cobalamin synthesis protein
H7696_22385	COG2095	MarC family integral membrane protein
H7696_22445	COG0247	lactate metabolic process
H7696_22445	COG0277	FAD linked oxidase domain protein
H7696_22460	COG1024	Enoyl-CoA hydratase
H7696_22465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7696_22470	COG1960	acyl-CoA dehydrogenase activity
H7696_22480	COG0183	Belongs to the thiolase family
H7696_22495	COG1024	Enoyl-CoA hydratase
H7696_22500	COG1024	Enoyl-CoA hydratase
H7696_22510	COG1028	Short-chain dehydrogenase reductase Sdr
H7696_22515	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H7696_22520	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7696_22525	COG1845	cytochrome c oxidase, subunit III
H7696_22530	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H7696_22535	COG0109	protoheme IX farnesyltransferase activity
H7696_22540	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7696_22540	COG1902	pentaerythritol trinitrate reductase activity
H7696_22555	COG1012	belongs to the aldehyde dehydrogenase family
H7696_22565	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H7696_22595	COG1126	abc transporter atp-binding protein
H7696_22600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7696_22605	COG4215	(ABC) transporter
H7696_22610	COG4160	amino acid transport
H7696_22680	COG0443	Heat shock 70 kDa protein
H7696_22685	COG2847	Copper chaperone PCu(A)C
H7696_22745	COG0814	amino acid
H7696_22755	COG0243	molybdopterin cofactor binding
H7696_22780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7696_22780	COG1116	anion transmembrane transporter activity
H7696_22785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7696_22790	COG1116	anion transmembrane transporter activity
H7696_22795	COG2146	nitrite reductase [NAD(P)H] activity
H7696_22795	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7696_22825	COG0745	RESPONSE REGULATOR receiver
H7696_22845	COG2815	serine threonine protein kinase
H7696_22845	COG0515	serine threonine protein kinase
H7696_22880	COG0631	protein serine/threonine phosphatase activity
H7696_22950	COG0420	3'-5' exonuclease activity
H7696_22955	COG0419	ATPase involved in DNA repair
H7696_22965	COG3040	lipid binding
H7696_22975	COG1288	antiporter activity
H7696_22985	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
H7696_23000	COG2425	protein containing a von Willebrand factor type A (vWA) domain
H7696_23015	COG0583	DNA-binding transcription factor activity
H7696_23020	COG0277	FAD linked oxidase domain protein
H7696_23035	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7696_23085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7696_23105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7696_23110	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7696_23120	COG2116	formate transmembrane transporter activity
H7696_23140	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H7696_23175	COG3118	belongs to the thioredoxin family
H7696_23180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7696_23205	COG2271	Major facilitator Superfamily
H7696_23210	COG3851	Histidine kinase
H7696_23215	COG2197	response regulator
H7696_23225	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H7696_23230	COG0583	DNA-binding transcription factor activity
H7696_23235	COG0243	molybdopterin cofactor binding
H7696_23250	COG0384	phenazine biosynthesis protein PhzF
H7696_23255	COG1794	racemase activity, acting on amino acids and derivatives
H7696_23285	COG1328	CTP reductase activity
H7696_23290	COG0602	queuosine metabolic process
H7696_23295	COG0534	Mate efflux family protein
H7696_23300	COG2207	Transcriptional regulator
H7696_23310	COG4067	protein conserved in archaea
H7696_23310	COG0189	ligase activity
H7696_23320	COG3111	PFAM Bacterial OB fold (BOF) protein
H7696_23330	COG0725	ABC transporter, periplasmic molybdate-binding protein
H7696_23335	COG4149	molybdate abc transporter
H7696_23340	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H7696_23350	COG2203	Gaf domain
H7696_23350	COG4251	negative regulation of phosphorylation
H7696_23350	COG5001	Diguanylate cyclase
H7696_23350	COG3706	GGDEF domain
H7696_23370	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H7696_23375	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H7696_23400	COG3140	Belongs to the UPF0181 family
H7696_23415	COG0583	DNA-binding transcription factor activity
H7696_23595	COG0023	Translation Initiation Factor
H7696_23605	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7696_23615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7696_23615	COG1042	CoA-binding domain protein
H7696_23615	COG0045	succinate-CoA ligase (ADP-forming) activity
H7696_23620	COG0583	DNA-binding transcription factor activity
H7696_23635	COG5001	Diguanylate cyclase
H7696_23635	COG3447	MASE1 domain protein
H7696_23635	COG5002	protein histidine kinase activity
H7696_23640	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H7696_23645	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H7696_23650	COG1984	allophanate hydrolase subunit 2
H7696_23660	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H7696_23665	COG4181	ATPase activity
H7696_23675	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7696_23680	COG3300	MHYT domain
H7696_23680	COG5001	Diguanylate cyclase
H7696_23715	COG4533	DNA binding
H7696_23725	COG2050	protein possibly involved in aromatic compounds catabolism
H7696_23740	COG2067	long-chain fatty acid transport protein
H7696_23745	COG2267	carboxylic ester hydrolase activity
H7696_23765	COG0861	Integral membrane protein TerC family
H7696_23770	COG0737	Belongs to the 5'-nucleotidase family
H7696_23775	COG3593	DNA synthesis involved in DNA repair
H7696_23785	COG0583	DNA-binding transcription factor activity
H7696_23790	COG2116	formate transmembrane transporter activity
H7696_23795	COG2353	YceI-like domain
H7696_23800	COG3038	cytochrome b561
H7696_23820	COG0513	Belongs to the DEAD box helicase family
H7696_23825	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
H7696_23835	COG0840	transmembrane signaling receptor activity
H7696_23840	COG0546	phosphoglycolate phosphatase activity
H7696_23855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7696_23860	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H7696_23865	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H7696_23875	COG2207	Transcriptional regulator
H7696_23880	COG1979	alcohol dehydrogenase
H7696_23890	COG1126	abc transporter atp-binding protein
H7696_23895	COG0765	amino acid transport
H7696_23900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7696_23905	COG0765	amino acid transport
H7696_23910	COG2203	Gaf domain
H7696_23910	COG2199	diguanylate cyclase activity
H7696_23910	COG2200	EAL domain
H7696_23925	COG1609	Transcriptional regulator
H7696_23930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7696_23930	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7696_23935	COG1105	Belongs to the carbohydrate kinase PfkB family
H7696_23940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7696_23940	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H7696_23940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7696_23970	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H7696_23980	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H7696_23985	COG0509	glycine decarboxylation via glycine cleavage system
H7696_23995	COG0346	lactoylglutathione lyase activity
H7696_24000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7696_24005	COG0583	DNA-binding transcription factor activity
H7696_24010	COG0697	spore germination
H7696_24015	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7696_24045	COG2176	DNA-directed DNA polymerase activity
H7696_24085	COG0242	peptide deformylase activity
H7696_24105	COG2239	Acts as a magnesium transporter
H7696_24125	COG0346	lactoylglutathione lyase activity
H7696_24130	COG1902	pentaerythritol trinitrate reductase activity
H7696_24140	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H7696_24140	COG2755	lipolytic protein G-D-S-L family
H7696_24150	COG5642	Protein of unknown function (DUF2384)
H7696_24155	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H7696_24190	COG2076	Multidrug Resistance protein
H7696_24210	COG2962	Rard protein
H7696_24225	COG0835	chemotaxis
H7696_24225	COG0784	Response regulator, receiver
H7696_24230	COG2197	response regulator
H7696_24240	COG3706	GGDEF domain
H7696_24245	COG2197	response regulator
H7696_24250	COG3300	MHYT domain
H7696_24250	COG5001	Diguanylate cyclase
H7696_24255	COG2205	protein histidine kinase activity
H7696_24255	COG0784	Response regulator, receiver
H7696_24260	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H7696_24280	COG0456	acetyltransferase
H7696_24280	COG1214	PFAM Peptidase M22, glycoprotease