locus-tag	class	description
VagYM19_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VagYM19_00020	COG0592	DNA-directed DNA polymerase activity
VagYM19_00040	COG0187	DNA topoisomerase II activity
VagYM19_00070	COG0071	Belongs to the small heat shock protein (HSP20) family
VagYM19_00080	COG3977	Valine--pyruvate aminotransferase
VagYM19_00090	COG0366	Alpha amylase catalytic
VagYM19_00100	COG0751	glycine-tRNA ligase activity
VagYM19_00120	COG2119	membrane
VagYM19_00140	COG0425	Belongs to the sulfur carrier protein TusA family
VagYM19_00170	COG0604	alcohol dehydrogenase
VagYM19_00180	COG0183	Belongs to the thiolase family
VagYM19_00200	COG1739	Uncharacterized protein family UPF0029
VagYM19_00210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VagYM19_00230	COG0583	DNA-binding transcription factor activity
VagYM19_00240	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VagYM19_00250	COG2960	long-chain fatty acid transporting porin activity
VagYM19_00260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VagYM19_00270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VagYM19_00330	COG4166	transmembrane transport
VagYM19_00350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VagYM19_00420	COG1609	Transcriptional regulator
VagYM19_00430	COG0583	DNA-binding transcription factor activity
VagYM19_00460	COG0129	dihydroxy-acid dehydratase activity
VagYM19_00470	COG3265	gluconokinase activity
VagYM19_00480	COG2610	gluconate transmembrane transporter activity
VagYM19_00490	COG0800	Aldolase
VagYM19_00500	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
VagYM19_00510	COG0583	DNA-binding transcription factor activity
VagYM19_00520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VagYM19_00530	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VagYM19_00550	COG1522	sequence-specific DNA binding
VagYM19_00560	COG5002	protein histidine kinase activity
VagYM19_00560	COG5001	Diguanylate cyclase
VagYM19_00570	COG0742	ribosomal rna small subunit methyltransferase
VagYM19_00600	COG0589	response to stress
VagYM19_00610	COG1528	Iron-storage protein
VagYM19_00630	COG2081	HI0933 family
VagYM19_00640	COG2204	response regulator
VagYM19_00690	COG1597	lipid kinase activity
VagYM19_00750	COG0628	permease
VagYM19_00780	COG1322	Protein conserved in bacteria
VagYM19_00790	COG2226	methyltransferase
VagYM19_00800	COG3165	ubiquinone biosynthetic process from chorismate
VagYM19_00810	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VagYM19_00830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VagYM19_00840	COG0805	protein transport
VagYM19_00850	COG0084	hydrolase, TatD family'
VagYM19_00870	COG0456	acetyltransferase
VagYM19_00880	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VagYM19_00880	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VagYM19_00890	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VagYM19_00950	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VagYM19_00970	COG2204	response regulator
VagYM19_00980	COG3852	Histidine kinase
VagYM19_01000	COG0174	glutamine synthetase
VagYM19_01040	COG1295	ribonuclease BN
VagYM19_01050	COG1490	D-aminoacyl-tRNA deacylase activity
VagYM19_01060	COG0456	acetyltransferase
VagYM19_01080	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VagYM19_01090	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VagYM19_01100	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VagYM19_01110	COG3031	protein transport across the cell outer membrane
VagYM19_01130	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VagYM19_01140	COG1459	type II secretion system
VagYM19_01150	COG2165	general secretion pathway protein
VagYM19_01160	COG2165	general secretion pathway protein
VagYM19_01170	COG2165	general secretion pathway protein
VagYM19_01180	COG4795	General secretion pathway protein
VagYM19_01190	COG3156	type II secretion system protein K
VagYM19_01200	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VagYM19_01210	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VagYM19_01230	COG1218	3'(2'),5'-bisphosphate nucleotidase
VagYM19_01240	COG0494	nUDIX hydrolase
VagYM19_01250	COG0316	Belongs to the HesB IscA family
VagYM19_01250	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VagYM19_01260	COG1040	competence protein
VagYM19_01270	COG0596	Alpha beta hydrolase
VagYM19_01290	COG2183	response to ionizing radiation
VagYM19_01310	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VagYM19_01330	COG0745	RESPONSE REGULATOR receiver
VagYM19_01340	COG2205	protein histidine kinase activity
VagYM19_01350	COG2233	PERMEase
VagYM19_01360	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VagYM19_01370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VagYM19_01380	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VagYM19_01390	COG1758	RNA polymerase activity
VagYM19_01400	COG0194	GDP metabolic process
VagYM19_01430	COG0848	biopolymer transport protein
VagYM19_01440	COG0811	peptide transport
VagYM19_01480	COG4174	ABC transporter (Permease)
VagYM19_01490	COG4239	(ABC) transporter, permease
VagYM19_01500	COG0747	negative chemotaxis
VagYM19_01510	COG0444	Belongs to the ABC transporter superfamily
VagYM19_01520	COG4608	Belongs to the ABC transporter superfamily
VagYM19_01540	COG1561	YicC-like family, N-terminal region
VagYM19_01550	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VagYM19_01570	COG1560	Kdo2-lipid A biosynthetic process
VagYM19_01580	COG1309	transcriptional regulator
VagYM19_01590	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VagYM19_01610	COG2003	Belongs to the UPF0758 family
VagYM19_01700	COG0463	Glycosyl transferase, family 2
VagYM19_01710	COG0859	PFAM glycosyl transferase family 9
VagYM19_01720	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VagYM19_01730	COG3642	lipopolysaccharide core region biosynthetic process
VagYM19_01770	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VagYM19_01790	COG1086	Polysaccharide biosynthesis protein
VagYM19_01800	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VagYM19_01810	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VagYM19_01820	COG2089	acid synthase
VagYM19_01840	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
VagYM19_01850	COG1083	cytidylyl-transferase
VagYM19_01870	COG1519	Transferase
VagYM19_01880	COG0859	PFAM glycosyl transferase family 9
VagYM19_01890	COG1560	Kdo2-lipid A biosynthetic process
VagYM19_01910	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VagYM19_02070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VagYM19_02080	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VagYM19_02090	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VagYM19_02140	COG1045	serine acetyltransferase
VagYM19_02170	COG0438	transferase activity, transferring glycosyl groups
VagYM19_02180	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VagYM19_02200	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VagYM19_02240	COG0149	triose-phosphate isomerase activity
VagYM19_02290	COG1494	fructose-1,6-bisphosphatase
VagYM19_02310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VagYM19_02320	COG1575	Belongs to the MenA family. Type 1 subfamily
VagYM19_02330	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VagYM19_02340	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VagYM19_02370	COG1609	Transcriptional regulator
VagYM19_02380	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VagYM19_02390	COG0254	rRNA binding
VagYM19_02410	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VagYM19_02420	COG0088	Forms part of the polypeptide exit tunnel
VagYM19_02440	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VagYM19_02450	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VagYM19_02460	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VagYM19_02470	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VagYM19_02490	COG0255	Belongs to the universal ribosomal protein uL29 family
VagYM19_02500	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VagYM19_02520	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VagYM19_02530	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VagYM19_02540	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VagYM19_02550	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VagYM19_02560	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VagYM19_02590	COG1841	ribosomal large subunit assembly
VagYM19_02610	COG0201	protein transport
VagYM19_02620	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VagYM19_02630	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VagYM19_02640	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VagYM19_02660	COG0202	RNA polymerase activity
VagYM19_02670	COG0203	ribosomal protein L17
VagYM19_02690	COG0545	Peptidyl-prolyl cis-trans isomerase
VagYM19_02710	COG2153	protein acetylation
VagYM19_02720	COG0513	Belongs to the DEAD box helicase family
VagYM19_02740	COG0737	Belongs to the 5'-nucleotidase family
VagYM19_02750	COG1648	precorrin-2 dehydrogenase activity
VagYM19_02750	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VagYM19_02760	COG0175	sulfate reduction
VagYM19_02770	COG2895	sulfate adenylyltransferase (ATP) activity
VagYM19_02780	COG0471	metal ion transport
VagYM19_02780	COG3273	potassium ion transport
VagYM19_02790	COG0529	Catalyzes the synthesis of activated sulfate
VagYM19_02840	COG4181	ATPase activity
VagYM19_02870	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VagYM19_02890	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VagYM19_02900	COG0729	surface antigen
VagYM19_02910	COG2911	Protein conserved in bacteria
VagYM19_02920	COG2105	PFAM AIG2 family protein
VagYM19_02940	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VagYM19_02950	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VagYM19_02960	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VagYM19_02970	COG0163	prenyltransferase activity
VagYM19_02980	COG4143	(ABC) transporter
VagYM19_02990	COG1178	ABC-type Fe3 transport system permease component
VagYM19_03000	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VagYM19_03010	COG0583	DNA-binding transcription factor activity
VagYM19_03020	COG1902	pentaerythritol trinitrate reductase activity
VagYM19_03050	COG2358	TRAP transporter, solute receptor (TAXI family
VagYM19_03090	COG0142	geranyltranstransferase activity
VagYM19_03100	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VagYM19_03120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VagYM19_03130	COG2966	Psort location CytoplasmicMembrane, score
VagYM19_03160	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VagYM19_03170	COG2967	ApaG domain
VagYM19_03180	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VagYM19_03190	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VagYM19_03200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VagYM19_03210	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VagYM19_03220	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VagYM19_03260	COG0473	3-isopropylmalate dehydrogenase activity
VagYM19_03270	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VagYM19_03310	COG0583	DNA-binding transcription factor activity
VagYM19_03320	COG1022	Amp-dependent synthetase and ligase
VagYM19_03330	COG0028	Belongs to the TPP enzyme family
VagYM19_03350	COG3706	GGDEF domain
VagYM19_03370	COG0469	pyruvate kinase activity
VagYM19_03380	COG1349	DNA-binding transcription factor activity
VagYM19_03390	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VagYM19_03420	COG5002	protein histidine kinase activity
VagYM19_03440	COG2376	Dihydroxyacetone kinase
VagYM19_03450	COG1461	Dihydroxyacetone kinase
VagYM19_03480	COG3722	fumarate hydratase activity
VagYM19_03490	COG0246	Mannitol dehydrogenase
VagYM19_03500	COG2213	PTS system mannitol-specific
VagYM19_03500	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VagYM19_03560	COG1464	Belongs to the NlpA lipoprotein family
VagYM19_03580	COG0358	DNA primase activity
VagYM19_03590	COG1610	YqeY-like protein
VagYM19_03600	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VagYM19_03610	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VagYM19_03620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
VagYM19_03630	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VagYM19_03640	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VagYM19_03650	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VagYM19_03660	COG1968	undecaprenyl-diphosphatase activity
VagYM19_03670	COG0617	tRNA 3'-terminal CCA addition
VagYM19_03680	COG3267	Type II secretory pathway component ExeA
VagYM19_03680	COG3409	Peptidoglycan-binding domain 1 protein
VagYM19_03700	COG0405	Gamma-glutamyltransferase
VagYM19_03710	COG4991	sh3 domain protein
VagYM19_03720	COG0306	phosphate transporter
VagYM19_03730	COG1392	Phosphate transport regulator
VagYM19_03740	COG3025	triphosphatase activity
VagYM19_03770	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VagYM19_03780	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VagYM19_03780	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VagYM19_03790	COG1538	Outer membrane efflux protein
VagYM19_03800	COG0494	nUDIX hydrolase
VagYM19_03810	COG3151	Protein conserved in bacteria
VagYM19_03830	COG3150	esterase
VagYM19_03850	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VagYM19_03860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VagYM19_03880	COG3105	Protein conserved in bacteria
VagYM19_03890	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VagYM19_03900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VagYM19_03910	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VagYM19_03920	COG0723	plastoquinol--plastocyanin reductase activity
VagYM19_03930	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VagYM19_03940	COG2857	Cytochrome c1
VagYM19_03950	COG0625	glutathione transferase activity
VagYM19_03960	COG2969	positive regulation of protein catabolic process
VagYM19_03970	COG2823	Periplasmic or secreted lipoprotein
VagYM19_03980	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VagYM19_04010	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VagYM19_04030	COG3116	cell division
VagYM19_04040	COG0768	penicillin binding
VagYM19_04050	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VagYM19_04060	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VagYM19_04070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VagYM19_04080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VagYM19_04090	COG0772	Belongs to the SEDS family
VagYM19_04110	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VagYM19_04120	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VagYM19_04130	COG0849	cell division
VagYM19_04140	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VagYM19_04150	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VagYM19_04170	COG0653	protein targeting
VagYM19_04180	COG0494	nUDIX hydrolase
VagYM19_04210	COG0505	Belongs to the CarA family
VagYM19_04220	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VagYM19_04250	COG0730	response to heat
VagYM19_04260	COG0583	DNA-binding transcription factor activity
VagYM19_04270	COG2860	membrane
VagYM19_04320	COG0493	'glutamate synthase
VagYM19_04330	COG0067	glutamate synthase
VagYM19_04330	COG0070	glutamate synthase
VagYM19_04330	COG0069	glutamate synthase activity
VagYM19_04350	COG0067	glutamate synthase
VagYM19_04350	COG0070	glutamate synthase
VagYM19_04350	COG0069	glutamate synthase activity
VagYM19_04360	COG1242	4 iron, 4 sulfur cluster binding
VagYM19_04370	COG5001	Diguanylate cyclase
VagYM19_04370	COG2203	Gaf domain
VagYM19_04370	COG4251	negative regulation of phosphorylation
VagYM19_04370	COG3706	GGDEF domain
VagYM19_04380	COG2198	Histidine kinase
VagYM19_04380	COG5002	protein histidine kinase activity
VagYM19_04380	COG0784	Response regulator, receiver
VagYM19_04400	COG0745	RESPONSE REGULATOR receiver
VagYM19_04420	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VagYM19_04450	COG0083	homoserine kinase activity
VagYM19_04460	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VagYM19_04480	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VagYM19_04490	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VagYM19_04500	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VagYM19_04530	COG1115	amino acid carrier protein
VagYM19_04540	COG3022	response to hydroperoxide
VagYM19_04550	COG0513	Belongs to the DEAD box helicase family
VagYM19_04560	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VagYM19_04580	COG0716	FMN binding
VagYM19_04590	COG4974	Belongs to the 'phage' integrase family
VagYM19_04600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VagYM19_04610	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VagYM19_04620	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VagYM19_04630	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VagYM19_04640	COG2204	response regulator
VagYM19_04670	COG0667	Aldo Keto reductase
VagYM19_04720	COG0730	response to heat
VagYM19_04740	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VagYM19_04760	COG1283	sodium-dependent phosphate transmembrane transporter activity
VagYM19_04770	COG0583	DNA-binding transcription factor activity
VagYM19_04780	COG0640	Transcriptional regulator
VagYM19_04790	COG0268	Binds directly to 16S ribosomal RNA
VagYM19_04800	COG0728	peptidoglycan biosynthetic process
VagYM19_04810	COG0196	riboflavin kinase activity
VagYM19_04830	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VagYM19_04840	COG1047	Peptidyl-prolyl cis-trans
VagYM19_04850	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VagYM19_04890	COG3279	Response regulator of the LytR AlgR family
VagYM19_04900	COG3275	phosphorelay sensor kinase activity
VagYM19_04910	COG1966	Carbon starvation protein
VagYM19_04950	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VagYM19_04960	COG1472	Belongs to the glycosyl hydrolase 3 family
VagYM19_04970	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VagYM19_04980	COG1605	Chorismate mutase
VagYM19_04980	COG0287	Prephenate dehydrogenase
VagYM19_04990	COG0739	heme binding
VagYM19_04990	COG1196	nuclear chromosome segregation
VagYM19_04990	COG0741	lytic transglycosylase activity
VagYM19_05010	COG0488	(ABC) transporter
VagYM19_05030	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VagYM19_05040	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VagYM19_05050	COG1605	Chorismate mutase
VagYM19_05050	COG0077	Prephenate dehydratase
VagYM19_05060	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VagYM19_05070	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VagYM19_05080	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VagYM19_05090	COG0564	pseudouridine synthase activity
VagYM19_05110	COG0542	response to heat
VagYM19_05150	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VagYM19_05170	COG2974	May be involved in recombination
VagYM19_05180	COG0745	RESPONSE REGULATOR receiver
VagYM19_05190	COG5002	protein histidine kinase activity
VagYM19_05210	COG0248	Ppx GppA phosphatase
VagYM19_05220	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VagYM19_05230	COG0573	inorganic phosphate transmembrane transporter activity
VagYM19_05240	COG0581	inorganic phosphate transmembrane transporter activity
VagYM19_05250	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VagYM19_05260	COG0704	Plays a role in the regulation of phosphate uptake
VagYM19_05280	COG3142	Participates in the control of copper homeostasis
VagYM19_05290	COG0450	alkyl hydroperoxide reductase
VagYM19_05300	COG0583	DNA-binding transcription factor activity
VagYM19_05310	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VagYM19_05330	COG0517	IMP dehydrogenase activity
VagYM19_05350	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VagYM19_05370	COG1862	Preprotein translocase
VagYM19_05380	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VagYM19_05390	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VagYM19_05400	COG0483	inositol monophosphate 1-phosphatase activity
VagYM19_05410	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
VagYM19_05430	COG1104	cysteine desulfurase activity
VagYM19_05440	COG0822	iron-sulfur transferase activity
VagYM19_05470	COG0443	Heat shock 70 kDa protein
VagYM19_05480	COG0633	Ferredoxin
VagYM19_05490	COG2975	iron-sulfur cluster assembly
VagYM19_05510	COG0105	UTP biosynthetic process
VagYM19_05540	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VagYM19_05550	COG0124	histidyl-tRNA synthetase
VagYM19_05560	COG2976	Protein conserved in bacteria
VagYM19_05570	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VagYM19_05580	COG1160	GTP binding
VagYM19_05620	COG0516	GMP reductase activity
VagYM19_05620	COG0517	IMP dehydrogenase activity
VagYM19_05630	COG0519	Catalyzes the synthesis of GMP from XMP
VagYM19_05630	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VagYM19_05640	COG0582	viral genome integration into host DNA
VagYM19_05810	COG1757	Na H antiporter
VagYM19_05830	COG1584	GPR1 FUN34 yaaH family protein
VagYM19_05840	COG1115	amino acid carrier protein
VagYM19_05880	COG2873	o-acetylhomoserine
VagYM19_05890	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VagYM19_05930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VagYM19_05930	COG3153	acetyltransferase
VagYM19_05940	COG0583	DNA-binding transcription factor activity
VagYM19_05960	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VagYM19_05970	COG2867	negative regulation of translational initiation
VagYM19_05980	COG2914	Belongs to the UPF0125 (RnfH) family
VagYM19_05990	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VagYM19_06000	COG0497	DNA recombination
VagYM19_06020	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VagYM19_06030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VagYM19_06040	COG1301	dicarboxylic acid transport
VagYM19_06060	COG0484	heat shock protein binding
VagYM19_06120	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VagYM19_06140	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VagYM19_06150	COG0047	phosphoribosylformylglycinamidine synthase activity
VagYM19_06150	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VagYM19_06180	COG1629	transport
VagYM19_06210	COG2195	Cleaves the N-terminal amino acid of tripeptides
VagYM19_06220	COG2252	PERMEase
VagYM19_06230	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VagYM19_06270	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VagYM19_06280	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VagYM19_06290	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VagYM19_06300	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VagYM19_06300	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VagYM19_06330	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VagYM19_06350	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VagYM19_06360	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VagYM19_06370	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VagYM19_06380	COG0142	geranyltranstransferase activity
VagYM19_06390	COG1722	exodeoxyribonuclease VII activity
VagYM19_06400	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VagYM19_06420	COG0301	tRNA thio-modification
VagYM19_06420	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VagYM19_06440	COG0583	DNA-binding transcription factor activity
VagYM19_06460	COG2363	Small membrane protein
VagYM19_06480	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VagYM19_06490	COG1611	Belongs to the LOG family
VagYM19_06520	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VagYM19_06520	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VagYM19_06540	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VagYM19_06550	COG1464	Belongs to the NlpA lipoprotein family
VagYM19_06560	COG2011	ABC-type metal ion transport system permease component
VagYM19_06570	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VagYM19_06580	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VagYM19_06600	COG1263	PTS System
VagYM19_06600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VagYM19_06610	COG0366	Alpha amylase catalytic
VagYM19_06650	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VagYM19_06660	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VagYM19_06670	COG0321	lipoyl(octanoyl) transferase activity
VagYM19_06690	COG1686	Belongs to the peptidase S11 family
VagYM19_06700	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VagYM19_06710	COG0772	Belongs to the SEDS family
VagYM19_06720	COG0768	penicillin binding
VagYM19_06730	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VagYM19_06740	COG0799	negative regulation of ribosome biogenesis
VagYM19_06750	COG1466	dna polymerase III delta subunit
VagYM19_06760	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VagYM19_06770	COG0495	leucyl-tRNA aminoacylation
VagYM19_06780	COG2888	peptidyl-tyrosine sulfation
VagYM19_06790	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VagYM19_06800	COG4535	Mg2 and Co2 transporter CorC
VagYM19_06810	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VagYM19_06820	COG1702	phosphate starvation-inducible protein PhoH
VagYM19_06830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VagYM19_06840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VagYM19_06850	COG0012	GTP binding
VagYM19_06860	COG0193	aminoacyl-tRNA hydrolase activity
VagYM19_06870	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VagYM19_06880	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VagYM19_06890	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
VagYM19_06900	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VagYM19_06920	COG2890	protein-(glutamine-N5) methyltransferase activity
VagYM19_06930	COG3094	Invasion gene expression up-regulator, SirB
VagYM19_06940	COG2912	Transglutaminase-like superfamily
VagYM19_06950	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VagYM19_06960	COG0737	Belongs to the 5'-nucleotidase family
VagYM19_06980	COG1187	pseudouridine synthase activity
VagYM19_06990	COG2840	Smr protein MutS2
VagYM19_07060	COG2608	mercury ion transmembrane transporter activity
VagYM19_07060	COG2217	Heavy metal translocating P-type atpase
VagYM19_07080	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VagYM19_07180	COG0835	chemotaxis
VagYM19_07180	COG0784	Response regulator, receiver
VagYM19_07190	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VagYM19_07200	COG1815	bacterial-type flagellum-dependent cell motility
VagYM19_07210	COG1558	bacterial-type flagellum-dependent cell motility
VagYM19_07230	COG1749	Flagellar hook protein flgE
VagYM19_07240	COG4787	bacterial-type flagellum-dependent cell motility
VagYM19_07260	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VagYM19_07270	COG1706	bacterial-type flagellum-dependent cell motility
VagYM19_07280	COG3951	Flagellar rod assembly protein muramidase FlgJ
VagYM19_07280	COG1705	Flagellar rod assembly protein muramidase FlgJ
VagYM19_07300	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VagYM19_07320	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VagYM19_07330	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VagYM19_07340	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VagYM19_07350	COG2190	(PTS) system
VagYM19_07360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VagYM19_07380	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VagYM19_07390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VagYM19_07400	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VagYM19_07410	COG3115	cell septum assembly
VagYM19_07420	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VagYM19_07470	COG0330	HflC and HflK could
VagYM19_07480	COG3118	belongs to the thioredoxin family
VagYM19_07490	COG0300	oxidoreductase activity
VagYM19_07500	COG1090	epimerase
VagYM19_07560	COG0622	Phosphoesterase
VagYM19_07600	COG3710	Transcriptional regulator
VagYM19_07610	COG0326	Molecular chaperone. Has ATPase activity
VagYM19_07630	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VagYM19_07650	COG3104	oligopeptide transport
VagYM19_07660	COG0250	Participates in transcription elongation, termination and antitermination
VagYM19_07670	COG0367	asparagine synthase
VagYM19_07680	COG4651	solute:proton antiporter activity
VagYM19_07680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VagYM19_07690	COG1940	carbohydrate kinase activity
VagYM19_07690	COG1846	Transcriptional regulator
VagYM19_07700	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VagYM19_07710	COG2190	(PTS) system
VagYM19_07710	COG1263	PTS System
VagYM19_07710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VagYM19_07720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VagYM19_07730	COG0735	belongs to the Fur family
VagYM19_07750	COG0716	FMN binding
VagYM19_07770	COG0596	Alpha beta hydrolase
VagYM19_07780	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VagYM19_07790	COG0033	Phosphoglucomutase
VagYM19_07810	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VagYM19_07840	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VagYM19_07850	COG1053	succinate dehydrogenase
VagYM19_07860	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VagYM19_07870	COG0567	Dehydrogenase, E1 component
VagYM19_07880	COG0508	dehydrogenase complex catalyzes the overall conversion of
VagYM19_07910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VagYM19_07920	COG1121	(ABC) transporter
VagYM19_07930	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VagYM19_07940	COG4977	sequence-specific DNA binding
VagYM19_07950	COG1918	ferrous iron import across plasma membrane
VagYM19_07990	COG0018	arginyl-trna synthetase
VagYM19_08000	COG3102	Protein conserved in bacteria
VagYM19_08030	COG0788	formyltetrahydrofolate deformylase activity
VagYM19_08040	COG1199	ATP-dependent helicase activity
VagYM19_08050	COG1214	PFAM Peptidase M22, glycoprotease
VagYM19_08070	COG3065	identical protein binding
VagYM19_08080	COG2267	carboxylic ester hydrolase activity
VagYM19_08090	COG0318	PFAM AMP-dependent synthetase and ligase
VagYM19_08100	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VagYM19_08110	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VagYM19_08120	COG2894	cell division
VagYM19_08130	COG0850	regulation of cytokinetic process
VagYM19_08140	COG3100	YcgL domain-containing protein
VagYM19_08150	COG2951	lytic endotransglycosylase activity
VagYM19_08170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VagYM19_08180	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VagYM19_08190	COG2226	methyltransferase
VagYM19_08200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VagYM19_08210	COG1028	Short-chain dehydrogenase reductase Sdr
VagYM19_08230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VagYM19_08280	COG2986	histidine ammonia-lyase
VagYM19_08290	COG1216	Glycosyl transferase, family 2
VagYM19_08300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VagYM19_08330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VagYM19_08340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VagYM19_08410	COG1253	flavin adenine dinucleotide binding
VagYM19_08420	COG0513	Belongs to the DEAD box helicase family
VagYM19_08430	COG0569	domain protein
VagYM19_08440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VagYM19_08470	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VagYM19_08480	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VagYM19_08490	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VagYM19_08500	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VagYM19_08530	COG0544	peptidyl-prolyl cis-trans isomerase activity
VagYM19_08550	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VagYM19_08560	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VagYM19_08570	COG0776	regulation of translation
VagYM19_08580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VagYM19_08590	COG1555	photosystem II stabilization
VagYM19_08620	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VagYM19_08630	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VagYM19_08640	COG0436	Aminotransferase
VagYM19_08650	COG1169	isochorismate synthase
VagYM19_08660	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VagYM19_08670	COG0596	Alpha beta hydrolase
VagYM19_08680	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VagYM19_08720	COG2855	membrane
VagYM19_08730	COG0477	Major facilitator Superfamily
VagYM19_08760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VagYM19_08770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VagYM19_08810	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VagYM19_08820	COG1522	sequence-specific DNA binding
VagYM19_08840	COG1946	Acyl-CoA thioesterase
VagYM19_08850	COG3126	Type III secretion system lipoprotein chaperone (YscW)
VagYM19_08990	COG0583	DNA-binding transcription factor activity
VagYM19_09000	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
VagYM19_09010	COG2207	Transcriptional regulator
VagYM19_09020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VagYM19_09030	COG0517	IMP dehydrogenase activity
VagYM19_09030	COG0516	GMP reductase activity
VagYM19_09080	COG0537	adenosine 5'-monophosphoramidase activity
VagYM19_09130	COG3150	esterase
VagYM19_09140	COG1252	NADH dehydrogenase
VagYM19_09170	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VagYM19_09190	COG4591	ABC-type transport system involved in lipoprotein release permease component
VagYM19_09200	COG1136	(ABC) transporter
VagYM19_09210	COG4591	ABC-type transport system involved in lipoprotein release permease component
VagYM19_09230	COG2333	competence protein COMEC
VagYM19_09230	COG0658	competence protein
VagYM19_09240	COG1132	(ABC) transporter
VagYM19_09250	COG1663	tetraacyldisaccharide 4'-kinase activity
VagYM19_09280	COG2719	SpoVR family
VagYM19_09290	COG2718	Belongs to the UPF0229 family
VagYM19_09300	COG2766	serine protein kinase
VagYM19_09310	COG3013	Belongs to the UPF0304 family
VagYM19_09330	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VagYM19_09350	COG1882	Formate acetyltransferase
VagYM19_09430	COG0708	Exodeoxyribonuclease III
VagYM19_09450	COG3923	Primosomal replication protein n
VagYM19_09460	COG0730	response to heat
VagYM19_09470	COG1199	ATP-dependent helicase activity
VagYM19_09480	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VagYM19_09490	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VagYM19_09500	COG1187	pseudouridine synthase activity
VagYM19_09520	COG1278	Cold shock
VagYM19_09530	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VagYM19_09540	COG0542	response to heat
VagYM19_09550	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VagYM19_09560	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VagYM19_09570	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VagYM19_09610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VagYM19_09620	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VagYM19_09630	COG0297	glycogen (starch) synthase activity
VagYM19_09670	COG3070	regulator of competence-specific genes
VagYM19_09680	COG1609	Transcriptional regulator
VagYM19_09690	COG3381	protein complex oligomerization
VagYM19_09700	COG0745	RESPONSE REGULATOR receiver
VagYM19_09710	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VagYM19_09720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VagYM19_09740	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VagYM19_09750	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VagYM19_09790	COG4067	protein conserved in archaea
VagYM19_09790	COG0189	ligase activity
VagYM19_09800	COG0500	methyltransferase
VagYM19_09820	COG1801	Protein of unknown function DUF72
VagYM19_09840	COG0217	transcriptional regulatory protein
VagYM19_09850	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VagYM19_09860	COG0632	four-way junction helicase activity
VagYM19_09870	COG2255	four-way junction helicase activity
VagYM19_09880	COG1271	oxidase subunit
VagYM19_09890	COG1294	oxidase, subunit
VagYM19_09900	COG4890	Cyd operon protein YbgT
VagYM19_09920	COG0824	Thioesterase
VagYM19_09930	COG0811	peptide transport
VagYM19_09960	COG0823	Involved in the tonB-independent uptake of proteins
VagYM19_09970	COG2885	chlorophyll binding
VagYM19_09980	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VagYM19_09990	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VagYM19_10010	COG3766	membrane
VagYM19_10030	COG0754	glutathionylspermidine amidase activity
VagYM19_10050	COG5002	protein histidine kinase activity
VagYM19_10050	COG0784	Response regulator, receiver
VagYM19_10070	COG0840	transmembrane signaling receptor activity
VagYM19_10080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VagYM19_10090	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VagYM19_10140	COG3568	Endonuclease Exonuclease Phosphatase
VagYM19_10160	COG0840	transmembrane signaling receptor activity
VagYM19_10190	COG0583	DNA-binding transcription factor activity
VagYM19_10210	COG0686	Belongs to the AlaDH PNT family
VagYM19_10230	COG1674	ftsk spoiiie
VagYM19_10240	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VagYM19_10250	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VagYM19_10260	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VagYM19_10320	COG1073	alpha beta
VagYM19_10320	COG2226	methyltransferase
VagYM19_10330	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VagYM19_10380	COG0300	oxidoreductase activity
VagYM19_10410	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VagYM19_10430	COG2268	Band 7 protein
VagYM19_10450	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VagYM19_10460	COG2915	High frequency lysogenization protein hflD homolog
VagYM19_10470	COG0482	sulfurtransferase activity
VagYM19_10490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VagYM19_10510	COG1757	Na H antiporter
VagYM19_10530	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VagYM19_10540	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VagYM19_10550	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VagYM19_10560	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VagYM19_10560	COG0131	Imidazoleglycerol-phosphate dehydratase
VagYM19_10570	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VagYM19_10580	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VagYM19_10600	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VagYM19_10600	COG0140	phosphoribosyl-ATP diphosphatase activity
VagYM19_10680	COG3850	Histidine kinase
VagYM19_10680	COG5002	protein histidine kinase activity
VagYM19_10690	COG0745	RESPONSE REGULATOR receiver
VagYM19_10700	COG0840	transmembrane signaling receptor activity
VagYM19_10730	COG1032	radical SAM domain protein
VagYM19_10740	COG5001	Diguanylate cyclase
VagYM19_10770	COG0583	DNA-binding transcription factor activity
VagYM19_10780	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VagYM19_10800	COG2350	Protein conserved in bacteria
VagYM19_10820	COG2917	probably involved in intracellular septation
VagYM19_10860	COG1301	dicarboxylic acid transport
VagYM19_10870	COG0318	PFAM AMP-dependent synthetase and ligase
VagYM19_10880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VagYM19_10890	COG0159	tryptophan synthase activity
VagYM19_10910	COG0134	indole-3-glycerol-phosphate synthase activity
VagYM19_10910	COG0135	phosphoribosylanthranilate isomerase activity
VagYM19_10930	COG0512	Glutamine amidotransferase of anthranilate synthase
VagYM19_10940	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VagYM19_10960	COG0613	PHP domain protein
VagYM19_10970	COG0009	L-threonylcarbamoyladenylate synthase
VagYM19_11000	COG1187	pseudouridine synthase activity
VagYM19_11040	COG0417	DNA replication proofreading
VagYM19_11050	COG2197	response regulator
VagYM19_11060	COG0322	excinuclease ABC activity
VagYM19_11100	COG0019	diaminopimelate decarboxylase activity
VagYM19_11160	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VagYM19_11170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VagYM19_11220	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VagYM19_11240	COG0437	4 iron, 4 sulfur cluster binding
VagYM19_11250	COG3301	Polysulphide reductase, NrfD
VagYM19_11260	COG1138	Cytochrome C-type biogenesis protein
VagYM19_11280	COG3088	subunit of a heme lyase
VagYM19_11280	COG4235	cytochrome complex assembly
VagYM19_11300	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VagYM19_11350	COG2989	Protein conserved in bacteria
VagYM19_11360	COG3108	Peptidase M15
VagYM19_11370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VagYM19_11400	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VagYM19_11460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VagYM19_11470	COG0840	transmembrane signaling receptor activity
VagYM19_11510	COG1448	Aminotransferase
VagYM19_11540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VagYM19_11560	COG0017	Asparaginyl-tRNA synthetase
VagYM19_11570	COG0840	transmembrane signaling receptor activity
VagYM19_11590	COG0720	synthase
VagYM19_11610	COG2200	EAL domain
VagYM19_11620	COG1760	l-serine dehydratase
VagYM19_11630	COG0814	amino acid
VagYM19_11640	COG0494	nUDIX hydrolase
VagYM19_11660	COG0784	Response regulator, receiver
VagYM19_11660	COG2205	protein histidine kinase activity
VagYM19_11670	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VagYM19_11700	COG3106	COG3106 Predicted ATPase
VagYM19_11710	COG3768	UPF0283 membrane protein
VagYM19_11730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VagYM19_12180	COG0729	surface antigen
VagYM19_12190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VagYM19_12200	COG2272	Belongs to the type-B carboxylesterase lipase family
VagYM19_12270	COG2985	domain, Protein
VagYM19_12290	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
VagYM19_12320	COG0583	DNA-binding transcription factor activity
VagYM19_12380	COG0210	DNA helicase
VagYM19_12410	COG4735	regulation of single-species biofilm formation
VagYM19_12480	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
VagYM19_12490	COG2944	sequence-specific DNA binding
VagYM19_12560	COG1566	PFAM secretion protein HlyD family protein
VagYM19_12590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VagYM19_12620	COG3290	protein histidine kinase activity
VagYM19_12630	COG4565	transcriptional regulatory protein
VagYM19_12640	COG4774	siderophore transport
VagYM19_12660	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VagYM19_12670	COG0363	glucosamine-6-phosphate deaminase activity
VagYM19_12680	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VagYM19_12710	COG3284	Transcriptional regulator
VagYM19_12720	COG1012	belongs to the aldehyde dehydrogenase family
VagYM19_12860	COG4669	(LipO)protein
VagYM19_12900	COG3177	Filamentation induced by cAMP protein fic
VagYM19_12960	COG1028	Short-chain dehydrogenase reductase Sdr
VagYM19_13010	COG4792	protein secretion
VagYM19_13020	COG4791	protein targeting
VagYM19_13030	COG4794	Type iii secretion
VagYM19_13040	COG4790	Type iii secretion
VagYM19_13180	COG0457	Tetratricopeptide repeat
VagYM19_13220	COG2358	TRAP transporter, solute receptor (TAXI family
VagYM19_13230	COG0730	response to heat
VagYM19_13300	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VagYM19_13310	COG0372	Belongs to the citrate synthase family
VagYM19_13330	COG2828	Protein conserved in bacteria
VagYM19_13380	COG0561	phosphatase activity
VagYM19_13390	COG0602	queuosine metabolic process
VagYM19_13400	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VagYM19_13410	COG3706	GGDEF domain
VagYM19_13510	COG1254	Belongs to the acylphosphatase family
VagYM19_13520	COG2920	part of a sulfur-relay system
VagYM19_13540	COG0670	Belongs to the BI1 family
VagYM19_13550	COG1126	abc transporter atp-binding protein
VagYM19_13560	COG0765	amino acid transport
VagYM19_13570	COG4597	amino acid ABC transporter
VagYM19_13580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VagYM19_13600	COG1666	GTP binding
VagYM19_13610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VagYM19_13660	COG3008	intermembrane lipid transfer
VagYM19_13670	COG2995	paraquat-inducible protein a
VagYM19_13680	COG1132	(ABC) transporter
VagYM19_13690	COG1956	GAF domain-containing protein
VagYM19_13700	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VagYM19_13730	COG0308	aminopeptidase N
VagYM19_13750	COG2902	Dehydrogenase
VagYM19_13760	COG0167	dihydroorotate dehydrogenase activity
VagYM19_13780	COG0116	Belongs to the methyltransferase superfamily
VagYM19_13780	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VagYM19_13830	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VagYM19_13840	COG1067	ATP-dependent peptidase activity
VagYM19_13850	COG3120	sequence-specific DNA binding
VagYM19_14120	COG0784	Response regulator, receiver
VagYM19_14120	COG2205	protein histidine kinase activity
VagYM19_14150	COG3278	Belongs to the heme-copper respiratory oxidase family
VagYM19_14180	COG2010	Cytochrome c
VagYM19_14200	COG2217	Heavy metal translocating P-type atpase
VagYM19_14230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VagYM19_14240	COG0589	response to stress
VagYM19_14290	COG3842	ATPase activity
VagYM19_14310	COG1177	transmembrane transport
VagYM19_14330	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VagYM19_14340	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VagYM19_14360	COG0004	ammonium transporteR
VagYM19_14410	COG0437	4 iron, 4 sulfur cluster binding
VagYM19_14420	COG0243	molybdopterin cofactor binding
VagYM19_14420	COG3383	formate dehydrogenase (NAD+) activity
VagYM19_14440	COG3381	protein complex oligomerization
VagYM19_14480	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VagYM19_14500	COG0488	(ABC) transporter
VagYM19_14510	COG4191	Histidine kinase
VagYM19_14520	COG2204	response regulator
VagYM19_14550	COG3842	ATPase activity
VagYM19_14560	COG0746	molybdenum cofactor guanylyltransferase activity
VagYM19_14590	COG1940	carbohydrate kinase activity
VagYM19_14660	COG0791	NLP P60 protein
VagYM19_14680	COG3706	GGDEF domain
VagYM19_14700	COG3001	Fructosamine kinase
VagYM19_14720	COG0307	riboflavin synthase, alpha
VagYM19_14730	COG0534	Mate efflux family protein
VagYM19_14750	COG1793	dna ligase
VagYM19_14810	COG2204	response regulator
VagYM19_14830	COG0438	transferase activity, transferring glycosyl groups
VagYM19_14890	COG0438	transferase activity, transferring glycosyl groups
VagYM19_14900	COG1215	transferase activity, transferring glycosyl groups
VagYM19_14910	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VagYM19_14930	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VagYM19_14960	COG1643	Atp-dependent helicase
VagYM19_14970	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VagYM19_15060	COG0443	Heat shock 70 kDa protein
VagYM19_15070	COG0443	Heat shock 70 kDa protein
VagYM19_15110	COG4968	Prepilin-type N-terminal cleavage methylation domain
VagYM19_15120	COG1132	(ABC) transporter
VagYM19_15130	COG1132	(ABC) transporter
VagYM19_15150	COG4774	siderophore transport
VagYM19_15160	COG4774	siderophore transport
VagYM19_15180	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VagYM19_15190	COG1120	ATPase activity
VagYM19_15220	COG0814	amino acid
VagYM19_15240	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VagYM19_15260	COG0861	Integral membrane protein TerC family
VagYM19_15280	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VagYM19_15290	COG1328	CTP reductase activity
VagYM19_15320	COG5001	Diguanylate cyclase
VagYM19_15320	COG3300	MHYT domain
VagYM19_15340	COG4191	Histidine kinase
VagYM19_15350	COG0471	metal ion transport
VagYM19_15400	COG4702	Belongs to the UPF0303 family
VagYM19_15410	COG0673	inositol 2-dehydrogenase activity
VagYM19_15450	COG0641	radical SAM
VagYM19_15490	COG3119	arylsulfatase activity
VagYM19_15500	COG0527	aspartate kinase activity
VagYM19_15510	COG0662	Cupin 2, conserved barrel domain protein
VagYM19_15520	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VagYM19_15530	COG0456	acetyltransferase
VagYM19_15540	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VagYM19_15580	COG4176	ABC-type proline glycine betaine transport system permease component
VagYM19_15590	COG2113	Glycine betaine
VagYM19_15630	COG1028	Short-chain dehydrogenase reductase Sdr
VagYM19_15650	COG0745	RESPONSE REGULATOR receiver
VagYM19_15660	COG0642	Histidine kinase
VagYM19_15670	COG1368	sulfuric ester hydrolase activity
VagYM19_15750	COG1115	amino acid carrier protein
VagYM19_15770	COG1280	lysine exporter protein (LysE YggA)
VagYM19_15780	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VagYM19_15850	COG1162	GTPase activity
VagYM19_15880	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VagYM19_15890	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VagYM19_15900	COG1160	GTP binding
VagYM19_15910	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
VagYM19_15930	COG1160	GTP binding
VagYM19_16000	COG1570	exodeoxyribonuclease VII activity
VagYM19_16100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VagYM19_16120	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VagYM19_16190	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
VagYM19_16200	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VagYM19_16210	COG1560	Kdo2-lipid A biosynthetic process
VagYM19_16230	COG0531	amino acid
VagYM19_16260	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
VagYM19_16270	COG3063	Type IV pilus biogenesis stability protein PilW
VagYM19_16330	COG0110	maltose O-acetyltransferase activity
VagYM19_16360	COG2315	Protein conserved in bacteria
VagYM19_16370	COG1846	Transcriptional regulator
VagYM19_16390	COG2200	EAL domain
VagYM19_16440	COG0625	glutathione transferase activity
VagYM19_16460	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VagYM19_16480	COG2195	Cleaves the N-terminal amino acid of tripeptides
VagYM19_16500	COG0601	transmembrane transport
VagYM19_16510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VagYM19_16550	COG3291	Pkd domain containing protein
VagYM19_16580	COG1177	transmembrane transport
VagYM19_16590	COG1176	ABC-type spermidine putrescine transport system, permease component I
VagYM19_16600	COG3842	ATPase activity
VagYM19_16610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VagYM19_16620	COG2423	ornithine cyclodeaminase activity
VagYM19_16650	COG3938	Belongs to the proline racemase family
VagYM19_16710	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
VagYM19_16720	COG1451	nucleotide metabolic process
VagYM19_16740	COG0583	DNA-binding transcription factor activity
VagYM19_16780	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
VagYM19_16790	COG4139	cobalamin transport
VagYM19_16800	COG2988	succinylglutamate desuccinylase activity
VagYM19_16840	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VagYM19_16850	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VagYM19_16860	COG0702	epimerase
VagYM19_16880	COG2925	Exonuclease
VagYM19_16890	COG1380	Effector of murein hydrolase LrgA
VagYM19_16900	COG1346	cytolysis
VagYM19_16910	COG0295	cytidine deaminase activity
VagYM19_16920	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VagYM19_16930	COG0500	methyltransferase
VagYM19_16950	COG0776	regulation of translation
VagYM19_16970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VagYM19_16970	COG0072	phenylalanine-tRNA ligase activity
VagYM19_16980	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VagYM19_17040	COG0393	Putative heavy-metal-binding
VagYM19_17060	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VagYM19_17080	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VagYM19_17110	COG2188	Transcriptional regulator
VagYM19_17120	COG1228	amidohydrolase
VagYM19_17130	COG0010	Belongs to the arginase family
VagYM19_17140	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VagYM19_17150	COG2986	histidine ammonia-lyase
VagYM19_17180	COG0277	FAD linked oxidase domain protein
VagYM19_17180	COG0247	lactate metabolic process
VagYM19_17250	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VagYM19_17280	COG1643	Atp-dependent helicase
VagYM19_17290	COG0281	malic enzyme
VagYM19_17300	COG2949	membrane
VagYM19_17310	COG0471	metal ion transport
VagYM19_17320	COG0471	metal ion transport
VagYM19_17380	COG0492	ferredoxin-NADP+ reductase activity
VagYM19_17390	COG4988	ABC transporter
VagYM19_17400	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VagYM19_17420	COG2885	chlorophyll binding
VagYM19_17460	COG3121	Chaperone
VagYM19_17480	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VagYM19_17500	COG4191	Histidine kinase
VagYM19_17500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VagYM19_17540	COG3070	regulator of competence-specific genes
VagYM19_17560	COG2431	L-lysine efflux transmembrane transporter activity
VagYM19_17580	COG0076	glutamate decarboxylase activity
VagYM19_17590	COG1737	Transcriptional regulator
VagYM19_17610	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VagYM19_17620	COG3273	potassium ion transport
VagYM19_17620	COG2985	domain, Protein
VagYM19_17630	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VagYM19_17640	COG1960	acyl-CoA dehydrogenase activity
VagYM19_17660	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VagYM19_17700	COG0534	Mate efflux family protein
VagYM19_17710	COG0702	epimerase
VagYM19_17720	COG3005	denitrification pathway
VagYM19_17780	COG2814	Major facilitator Superfamily
VagYM19_17790	COG1187	pseudouridine synthase activity
VagYM19_17800	COG1061	Type III restriction enzyme res subunit
VagYM19_17820	COG0745	RESPONSE REGULATOR receiver
VagYM19_17830	COG2205	protein histidine kinase activity
VagYM19_17840	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VagYM19_17890	COG4134	Bacterial extracellular solute-binding protein
VagYM19_17900	COG4135	transport system, permease component
VagYM19_17910	COG4136	ATPase activity
VagYM19_17920	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VagYM19_17940	COG3604	Transcriptional regulator
VagYM19_17950	COG1151	hydroxylamine reductase activity
VagYM19_17960	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VagYM19_17980	COG0564	pseudouridine synthase activity
VagYM19_17990	COG0733	neurotransmitter:sodium symporter activity
VagYM19_18000	COG0733	neurotransmitter:sodium symporter activity
VagYM19_18020	COG0626	cystathionine gamma-synthase activity
VagYM19_18030	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
VagYM19_18040	COG5380	lipid catabolic process
VagYM19_18050	COG2818	Glycosylase
VagYM19_18090	COG1983	PspC domain protein
VagYM19_18110	COG1842	Phage shock protein A
VagYM19_18120	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VagYM19_18150	COG4171	peptide transport system, permease
VagYM19_18170	COG4172	Belongs to the ABC transporter superfamily
VagYM19_18190	COG1227	inorganic diphosphatase activity
VagYM19_18220	COG0243	molybdopterin cofactor binding
VagYM19_18230	COG3005	denitrification pathway
VagYM19_18240	COG4459	periplasmic nitrate reductase
VagYM19_18250	COG0390	transport system, permease component
VagYM19_18270	COG2116	formate transmembrane transporter activity
VagYM19_18320	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VagYM19_18330	COG1435	thymidine kinase activity
VagYM19_18340	COG0215	cysteine-tRNA ligase activity
VagYM19_18350	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VagYM19_18360	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VagYM19_18370	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VagYM19_18380	COG3012	SEC-C Motif Domain Protein
VagYM19_18440	COG0577	efflux transmembrane transporter activity
VagYM19_18440	COG1136	(ABC) transporter
VagYM19_18460	COG1136	(ABC) transporter
VagYM19_18460	COG0577	efflux transmembrane transporter activity
VagYM19_18480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VagYM19_18530	COG3118	belongs to the thioredoxin family
VagYM19_18540	COG4232	protein-disulfide reductase activity
VagYM19_18610	COG2863	cytochrome
VagYM19_18620	COG3258	Cytochrome c
VagYM19_18630	COG2995	paraquat-inducible protein a
VagYM19_18640	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VagYM19_18640	COG3008	intermembrane lipid transfer
VagYM19_18670	COG4166	transmembrane transport
VagYM19_18690	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VagYM19_18700	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VagYM19_18720	COG0539	negative regulation of cytoplasmic translation
VagYM19_18730	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VagYM19_18740	COG0616	signal peptide processing
VagYM19_18750	COG1028	Short-chain dehydrogenase reductase Sdr
VagYM19_18780	COG0587	DNA-directed DNA polymerase activity
VagYM19_18790	COG0835	chemotaxis
VagYM19_18790	COG0784	Response regulator, receiver
VagYM19_18800	COG1940	carbohydrate kinase activity
VagYM19_18810	COG0469	pyruvate kinase activity
VagYM19_18820	COG4667	esterase of the alpha-beta hydrolase superfamily
VagYM19_18850	COG0733	neurotransmitter:sodium symporter activity
VagYM19_18880	COG1263	PTS System
VagYM19_18880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VagYM19_18890	COG0084	hydrolase, TatD family'
VagYM19_18900	COG0470	DNA polymerase III
VagYM19_18910	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VagYM19_18920	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VagYM19_18980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VagYM19_18990	COG0416	fatty acid biosynthetic process
VagYM19_19010	COG1399	metal-binding, possibly nucleic acid-binding protein
VagYM19_19020	COG0424	maF-like protein
VagYM19_19030	COG0564	pseudouridine synthase activity
VagYM19_19040	COG1530	ribonuclease E activity
VagYM19_19050	COG0659	secondary active sulfate transmembrane transporter activity
VagYM19_19060	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VagYM19_19070	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VagYM19_19090	COG0572	uridine kinase
VagYM19_19140	COG2186	Transcriptional regulator
VagYM19_19150	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VagYM19_19160	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VagYM19_19170	COG0653	protein targeting
VagYM19_19180	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VagYM19_19190	COG3706	GGDEF domain
VagYM19_19200	COG0366	Alpha amylase catalytic
VagYM19_19210	COG1122	ATPase activity
VagYM19_19220	COG4120	Belongs to the binding-protein-dependent transport system permease family
VagYM19_19240	COG3092	negative regulation of chromosome organization
VagYM19_19250	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VagYM19_19260	COG0857	belongs to the CobB CobQ family
VagYM19_19260	COG0280	phosphate acetyltransferase
VagYM19_19270	COG3174	membrane
VagYM19_19290	COG0435	Glutathione S-transferase
VagYM19_19310	COG0444	Belongs to the ABC transporter superfamily
VagYM19_19320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VagYM19_19330	COG0601	transmembrane transport
VagYM19_19350	COG0314	molybdopterin synthase activity
VagYM19_19360	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VagYM19_19370	COG0315	cyclic pyranopterin monophosphate synthase activity
VagYM19_19380	COG0521	Mo-molybdopterin cofactor biosynthetic process
VagYM19_19390	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VagYM19_19400	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VagYM19_19410	COG2198	Histidine kinase
VagYM19_19420	COG2204	response regulator
VagYM19_19430	COG0556	nucleotide-excision repair
VagYM19_19440	COG4657	Part of a membrane complex involved in electron transport
VagYM19_19450	COG2878	Part of a membrane complex involved in electron transport
VagYM19_19460	COG4656	Part of a membrane complex involved in electron transport
VagYM19_19470	COG4658	electron transport chain
VagYM19_19480	COG4659	FMN binding
VagYM19_19490	COG4660	Part of a membrane complex involved in electron transport
VagYM19_19500	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VagYM19_19510	COG0346	lactoylglutathione lyase activity
VagYM19_19530	COG2885	chlorophyll binding
VagYM19_19550	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VagYM19_19560	COG2056	Na+-H+ antiporter family
VagYM19_19580	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VagYM19_19620	COG1012	belongs to the aldehyde dehydrogenase family
VagYM19_19620	COG1454	alcohol dehydrogenase
VagYM19_19630	COG2095	MarC family integral membrane protein
VagYM19_19640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VagYM19_19650	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VagYM19_19660	COG1757	Na H antiporter
VagYM19_19690	COG3081	Nucleoid-associated protein
VagYM19_19700	COG3082	Protein of unknown function (DUF1414)
VagYM19_19720	COG0123	including yeast histone deacetylase and acetoin utilization protein
VagYM19_19750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VagYM19_19760	COG0778	Nitroreductase
VagYM19_19780	COG0446	pyridine nucleotide-disulphide oxidoreductase
VagYM19_19780	COG1902	pentaerythritol trinitrate reductase activity
VagYM19_19790	COG0616	signal peptide processing
VagYM19_19800	COG0252	asparaginase activity
VagYM19_19810	COG3139	Protein of unknown function (DUF1315)
VagYM19_19830	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VagYM19_19840	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VagYM19_19870	COG2226	methyltransferase
VagYM19_19900	COG1785	Belongs to the alkaline phosphatase family
VagYM19_19920	COG0346	lactoylglutathione lyase activity
VagYM19_19930	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
VagYM19_19940	COG0668	transmembrane transport
VagYM19_19950	COG2983	Belongs to the UPF0260 family
VagYM19_19960	COG2261	transglycosylase associated protein
VagYM19_19990	COG3681	Belongs to the UPF0597 family
VagYM19_20000	COG0251	oxidation-reduction process
VagYM19_20010	COG0814	amino acid
VagYM19_20020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VagYM19_20030	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VagYM19_20060	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VagYM19_20070	COG2832	Protein of unknown function (DUF454)
VagYM19_20090	COG0745	RESPONSE REGULATOR receiver
VagYM19_20100	COG0583	DNA-binding transcription factor activity
VagYM19_20110	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VagYM19_20120	COG1286	toxin biosynthetic process
VagYM19_20130	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VagYM19_20140	COG0285	dihydrofolate synthase activity
VagYM19_20150	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VagYM19_20160	COG0101	tRNA pseudouridine synthase activity
VagYM19_20180	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VagYM19_20190	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VagYM19_20200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VagYM19_20210	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VagYM19_20210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VagYM19_20220	COG0431	NADPH-dependent FMN reductase
VagYM19_20240	COG3101	peptidyl-lysine hydroxylation
VagYM19_20250	COG2860	membrane
VagYM19_20260	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VagYM19_20270	COG2890	protein-(glutamine-N5) methyltransferase activity
VagYM19_20280	COG2840	Smr protein MutS2
VagYM19_20290	COG2062	phosphohistidine phosphatase, SixA
VagYM19_20320	COG1024	Enoyl-CoA hydratase
VagYM19_20320	COG1250	3-hydroxyacyl-CoA dehydrogenase
VagYM19_20330	COG0183	Belongs to the thiolase family
VagYM19_20370	COG2067	long-chain fatty acid transport protein
VagYM19_20390	COG3088	subunit of a heme lyase
VagYM19_20390	COG4235	cytochrome complex assembly
VagYM19_20410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VagYM19_20420	COG1138	Cytochrome C-type biogenesis protein
VagYM19_20430	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VagYM19_20440	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VagYM19_20450	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VagYM19_20460	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VagYM19_20470	COG4133	protoheme IX ABC transporter activity
VagYM19_20490	COG0835	chemotaxis
VagYM19_20510	COG1192	Involved in chromosome partitioning
VagYM19_20520	COG2201	protein-glutamate methylesterase activity
VagYM19_20530	COG0784	Response regulator, receiver
VagYM19_20530	COG2198	Histidine kinase
VagYM19_20530	COG0643	Histidine kinase
VagYM19_20540	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VagYM19_20630	COG1987	bacterial-type flagellum assembly
VagYM19_20730	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VagYM19_20750	COG1677	Flagellar hook-basal body complex protein FliE
VagYM19_20770	COG4191	Histidine kinase
VagYM19_20790	COG1516	flagellar protein fliS
VagYM19_20810	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VagYM19_20820	COG1334	flagellar protein FlaG
VagYM19_20830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VagYM19_20840	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VagYM19_20850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VagYM19_20860	COG2837	iron assimilation
VagYM19_20910	COG1393	Belongs to the ArsC family
VagYM19_20920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VagYM19_20960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VagYM19_20980	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VagYM19_21010	COG4783	chaperone-mediated protein folding
VagYM19_21020	COG1393	Belongs to the ArsC family
VagYM19_21060	COG2233	PERMEase
VagYM19_21070	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VagYM19_21080	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VagYM19_21090	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VagYM19_21100	COG0121	glutamine amidotransferase
VagYM19_21110	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VagYM19_21120	COG1960	acyl-CoA dehydrogenase activity
VagYM19_21190	COG0328	RNA-DNA hybrid ribonuclease activity
VagYM19_21200	COG2226	methyltransferase
VagYM19_21210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VagYM19_21220	COG1388	LysM domain
VagYM19_21220	COG0741	lytic transglycosylase activity
VagYM19_21240	COG3021	interspecies interaction between organisms
VagYM19_21250	COG0347	Belongs to the P(II) protein family
VagYM19_21280	COG0825	malonyl-CoA metabolic process
VagYM19_21290	COG0587	DNA-directed DNA polymerase activity
VagYM19_21310	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VagYM19_21320	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VagYM19_21340	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VagYM19_21350	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VagYM19_21370	COG0750	zinc metalloprotease
VagYM19_21380	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VagYM19_21390	COG0575	Belongs to the CDS family
VagYM19_21400	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VagYM19_21410	COG0233	cytoplasmic translational termination
VagYM19_21420	COG0528	UMP kinase activity
VagYM19_21430	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VagYM19_21440	COG0052	Belongs to the universal ribosomal protein uS2 family
VagYM19_21450	COG0024	Methionine aminopeptidase
VagYM19_21460	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VagYM19_21480	COG0564	pseudouridine synthase activity
VagYM19_21550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VagYM19_21560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VagYM19_21610	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VagYM19_21620	COG0254	rRNA binding
VagYM19_21630	COG1720	tRNA m6t6A37 methyltransferase activity
VagYM19_21640	COG0442	prolyl-tRNA aminoacylation
VagYM19_21680	COG0733	neurotransmitter:sodium symporter activity
VagYM19_21710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VagYM19_21720	COG0514	ATP-dependent DNA helicase (RecQ)
VagYM19_21730	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VagYM19_21760	COG1477	protein flavinylation
VagYM19_21770	COG2871	sodium ion transport
VagYM19_21780	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VagYM19_21790	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VagYM19_21800	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VagYM19_21810	COG1805	sodium ion transport
VagYM19_21820	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VagYM19_21830	COG0271	Belongs to the BolA IbaG family
VagYM19_21840	COG2813	Specifically methylates the guanine in position
VagYM19_21850	COG3056	Lipoprotein
VagYM19_21890	COG1595	DNA-templated transcription, initiation
VagYM19_21930	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VagYM19_21940	COG0693	protein deglycase activity
VagYM19_21950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VagYM19_21960	COG3706	GGDEF domain
VagYM19_21980	COG2166	iron-sulfur cluster assembly
VagYM19_21990	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VagYM19_22000	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VagYM19_22020	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VagYM19_22020	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VagYM19_22060	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VagYM19_22070	COG1074	ATP-dependent DNA helicase activity
VagYM19_22080	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VagYM19_22120	COG3141	response to X-ray
VagYM19_22130	COG2171	N-acyltransferase activity
VagYM19_22140	COG0584	glycerophosphoryl diester phosphodiesterase
VagYM19_22150	COG2271	Major facilitator Superfamily
VagYM19_22160	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VagYM19_22170	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VagYM19_22180	COG1349	DNA-binding transcription factor activity
VagYM19_22190	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VagYM19_22230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VagYM19_22240	COG1609	Transcriptional regulator
VagYM19_22250	COG2211	Major facilitator Superfamily
VagYM19_22280	COG2017	converts alpha-aldose to the beta-anomer
VagYM19_22290	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VagYM19_22310	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VagYM19_22320	COG1609	Transcriptional regulator
VagYM19_22330	COG3250	beta-galactosidase activity
VagYM19_22340	COG2731	YhcH YjgK YiaL family protein
VagYM19_22350	COG0531	amino acid
VagYM19_22360	COG0583	DNA-binding transcription factor activity
VagYM19_22480	COG4964	Belongs to the GSP D family
VagYM19_22530	COG2169	Transcriptional regulator
VagYM19_22540	COG1022	Amp-dependent synthetase and ligase
VagYM19_22560	COG0583	DNA-binding transcription factor activity
VagYM19_22570	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VagYM19_22580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VagYM19_22600	COG0560	Phosphoserine phosphatase
VagYM19_22620	COG0813	purine-nucleoside phosphorylase activity
VagYM19_22630	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VagYM19_22640	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VagYM19_22660	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VagYM19_22670	COG0084	hydrolase, TatD family'
VagYM19_22690	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VagYM19_22840	COG0191	fructose-bisphosphate aldolase activity
VagYM19_22890	COG0501	Belongs to the peptidase M48B family
VagYM19_22920	COG0542	response to heat
VagYM19_22950	COG0443	Heat shock 70 kDa protein
VagYM19_22960	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VagYM19_22990	COG0071	Belongs to the small heat shock protein (HSP20) family
VagYM19_23000	COG0071	Belongs to the small heat shock protein (HSP20) family
VagYM19_23120	COG2003	Belongs to the UPF0758 family
VagYM19_23170	COG0714	Associated with various cellular activities
VagYM19_23210	COG0629	single-stranded DNA binding
VagYM19_23250	COG3385	transposase activity
VagYM19_23270	COG3344	reverse transcriptase
VagYM19_23300	COG0668	transmembrane transport
VagYM19_23310	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VagYM19_23400	COG0681	Belongs to the peptidase S26 family
VagYM19_23430	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VagYM19_23670	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VagYM19_23790	COG3153	acetyltransferase
VagYM19_23800	COG3154	lipid carrier protein
VagYM19_23820	COG0826	peptidase U32
VagYM19_23830	COG0826	peptidase U32
VagYM19_23840	COG0534	Mate efflux family protein
VagYM19_23870	COG1185	polyribonucleotide nucleotidyltransferase activity
VagYM19_23880	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VagYM19_23890	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VagYM19_23900	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VagYM19_23910	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VagYM19_23920	COG0195	Participates in both transcription termination and antitermination
VagYM19_23930	COG0779	Required for maturation of 30S ribosomal subunits
VagYM19_23940	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VagYM19_23950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VagYM19_23960	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VagYM19_23970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VagYM19_23980	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VagYM19_23990	COG1534	Rna-binding protein
VagYM19_24000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VagYM19_24010	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VagYM19_24020	COG2027	D-alanyl-D-alanine carboxypeptidase
VagYM19_24040	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VagYM19_24050	COG0739	heme binding
VagYM19_24090	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VagYM19_24100	COG0628	permease
VagYM19_24120	COG0784	Response regulator, receiver
VagYM19_24120	COG2205	protein histidine kinase activity
VagYM19_24130	COG0747	negative chemotaxis
VagYM19_24160	COG0444	Belongs to the ABC transporter superfamily
VagYM19_24170	COG4608	Belongs to the ABC transporter superfamily
VagYM19_24190	COG2971	BadF BadG BcrA BcrD
VagYM19_24220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VagYM19_24230	COG3842	ATPase activity
VagYM19_24250	COG1840	ABC-type Fe3 transport system, periplasmic component
VagYM19_24260	COG0004	ammonium transporteR
VagYM19_24270	COG0347	Belongs to the P(II) protein family
VagYM19_24280	COG3112	Uncharacterised protein family (UPF0231)
VagYM19_24290	COG1049	propionate catabolic process, 2-methylcitrate cycle
VagYM19_24300	COG1752	Esterase of the alpha-beta hydrolase superfamily
VagYM19_24310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VagYM19_24320	COG1643	Atp-dependent helicase
VagYM19_24330	COG1489	DNA binding
VagYM19_24350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VagYM19_24370	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VagYM19_24380	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VagYM19_24390	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VagYM19_24400	COG1560	Kdo2-lipid A biosynthetic process
VagYM19_24410	COG0842	Transport permease protein
VagYM19_24420	COG1131	(ABC) transporter
VagYM19_24430	COG0659	secondary active sulfate transmembrane transporter activity
VagYM19_24440	COG0288	reversible hydration of carbon dioxide
VagYM19_24470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VagYM19_24480	COG0508	dehydrogenase complex catalyzes the overall conversion of
VagYM19_24490	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VagYM19_24500	COG2186	Transcriptional regulator
VagYM19_24520	COG0157	Belongs to the NadC ModD family
VagYM19_24540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VagYM19_24550	COG1459	type II secretion system
VagYM19_24570	COG0237	dephospho-CoA kinase activity
VagYM19_24580	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VagYM19_24590	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VagYM19_24620	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VagYM19_24630	COG0228	four-way junction DNA binding
VagYM19_24640	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VagYM19_24650	COG4137	Cytochrome C assembly protein
VagYM19_24660	COG4536	flavin adenine dinucleotide binding
VagYM19_24670	COG1854	S-ribosylhomocysteine lyase activity
VagYM19_24700	COG0612	Peptidase, M16
VagYM19_24710	COG1238	metal cluster binding
VagYM19_24730	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VagYM19_24740	COG0511	ligase activity, forming carbon-carbon bonds
VagYM19_24740	COG5016	pyruvate
VagYM19_24750	COG3630	sodium ion export across plasma membrane
VagYM19_24770	COG0527	aspartate kinase activity
VagYM19_24780	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VagYM19_24790	COG2137	regulation of response to DNA damage stimulus
VagYM19_24800	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VagYM19_24810	COG1546	Belongs to the CinA family
VagYM19_24820	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VagYM19_24830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VagYM19_24850	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VagYM19_24860	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VagYM19_24880	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VagYM19_24890	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VagYM19_24900	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VagYM19_24910	COG0148	phosphopyruvate hydratase activity
VagYM19_24920	COG0504	CTP synthase activity
VagYM19_24930	COG3956	TIGRFAM MazG family protein
VagYM19_24940	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VagYM19_24950	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VagYM19_24970	COG0736	holo-[acyl-carrier-protein] synthase activity
VagYM19_24980	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VagYM19_24990	COG1381	Involved in DNA repair and RecF pathway recombination
VagYM19_25000	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VagYM19_25020	COG0681	Belongs to the peptidase S26 family
VagYM19_25030	COG0481	GTPase activity
VagYM19_25040	COG3086	response to oxidative stress
VagYM19_25070	COG1595	DNA-templated transcription, initiation
VagYM19_25080	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VagYM19_25100	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VagYM19_25110	COG0354	folic acid binding
VagYM19_25140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VagYM19_25150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VagYM19_25160	COG3079	Belongs to the UPF0149 family
VagYM19_25170	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VagYM19_25180	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VagYM19_25190	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VagYM19_25200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VagYM19_25220	COG0583	DNA-binding transcription factor activity
VagYM19_25250	COG0668	transmembrane transport
VagYM19_25260	COG0191	fructose-bisphosphate aldolase activity
VagYM19_25270	COG0126	phosphoglycerate kinase activity
VagYM19_25280	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VagYM19_25290	COG4771	TonB-dependent receptor
VagYM19_25300	COG0583	DNA-binding transcription factor activity
VagYM19_25310	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VagYM19_25320	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VagYM19_25350	COG2356	endonuclease I
VagYM19_25360	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VagYM19_25370	COG0189	ligase activity
VagYM19_25380	COG1678	Uncharacterized ACR, COG1678
VagYM19_25390	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VagYM19_25420	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VagYM19_25430	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VagYM19_25440	COG0762	integral membrane protein
VagYM19_25450	COG1872	DUF167
VagYM19_25470	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VagYM19_25480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VagYM19_25490	COG2066	Belongs to the glutaminase family
VagYM19_25510	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VagYM19_25530	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VagYM19_25570	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VagYM19_25590	COG3394	polysaccharide catabolic process
VagYM19_25600	COG1486	melibiose metabolic process
VagYM19_25610	COG1447	Phosphotransferase system cellobiose-specific component IIA
VagYM19_25620	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VagYM19_25630	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VagYM19_25640	COG0726	polysaccharide deacetylase
VagYM19_25650	COG3706	GGDEF domain
VagYM19_25660	COG3547	Transposase (IS116 IS110 IS902 family)
VagYM19_25670	COG3547	Transposase (IS116 IS110 IS902 family)
VagYM19_25950	COG1028	Short-chain dehydrogenase reductase Sdr
VagYM19_25980	COG0795	lipopolysaccharide-transporting ATPase activity
VagYM19_25990	COG0795	lipopolysaccharide-transporting ATPase activity
VagYM19_26010	COG2927	DNA polymerase III (CHI subunit)
VagYM19_26020	COG0525	valine-tRNA ligase activity
VagYM19_26100	COG0540	Belongs to the ATCase OTCase family
VagYM19_26110	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VagYM19_26120	COG0251	oxidation-reduction process
VagYM19_26130	COG0204	Acyl-transferase
VagYM19_26150	COG5007	Belongs to the BolA IbaG family
VagYM19_26170	COG2854	intermembrane phospholipid transfer
VagYM19_26180	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VagYM19_26190	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VagYM19_26200	COG1127	ABC transporter
VagYM19_26220	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VagYM19_26220	COG0517	IMP dehydrogenase activity
VagYM19_26240	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VagYM19_26250	COG1137	ATPase activity
VagYM19_26270	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VagYM19_26280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VagYM19_26290	COG1660	Displays ATPase and GTPase activities
VagYM19_26300	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VagYM19_26310	COG2239	Acts as a magnesium transporter
VagYM19_26320	COG0312	modulator of DNA gyrase
VagYM19_26330	COG3028	Belongs to the UPF0307 family
VagYM19_26340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VagYM19_26350	COG0564	pseudouridine synthase activity
VagYM19_26370	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VagYM19_26380	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VagYM19_26390	COG0312	modulator of DNA gyrase
VagYM19_26400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VagYM19_26410	COG3164	Protein of unknown function
VagYM19_26420	COG1530	ribonuclease E activity
VagYM19_26430	COG0424	maF-like protein
VagYM19_26440	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VagYM19_26450	COG1792	Involved in formation and maintenance of cell shape
VagYM19_26460	COG1077	Cell shape determining protein MreB Mrl
VagYM19_26550	COG1459	type II secretion system
VagYM19_26560	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VagYM19_26580	COG3409	Peptidoglycan-binding domain 1 protein
VagYM19_26580	COG3267	Type II secretory pathway component ExeA
VagYM19_26590	COG1450	Type ii and iii secretion system protein
VagYM19_26630	COG2199	diguanylate cyclase activity
VagYM19_26630	COG2200	EAL domain
VagYM19_26650	COG0629	single-stranded DNA binding
VagYM19_26680	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VagYM19_26700	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VagYM19_26710	COG0527	aspartate kinase activity
VagYM19_26720	COG1410	methionine synthase
VagYM19_26720	COG0646	methionine synthase
VagYM19_26760	COG0175	sulfate reduction
VagYM19_26770	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VagYM19_26780	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VagYM19_26820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VagYM19_26870	COG0247	lactate metabolic process
VagYM19_26880	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
VagYM19_26890	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VagYM19_27030	COG0735	belongs to the Fur family
VagYM19_27050	COG0166	Belongs to the GPI family
VagYM19_27070	COG0432	Pfam Uncharacterised protein family UPF0047
VagYM19_27080	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VagYM19_27130	COG2965	DNA replication, synthesis of RNA primer
VagYM19_27140	COG0360	Binds together with S18 to 16S ribosomal RNA
VagYM19_27150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VagYM19_27160	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VagYM19_27180	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VagYM19_27190	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VagYM19_27250	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VagYM19_27270	COG0678	peroxiredoxin activity
VagYM19_27270	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VagYM19_27280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VagYM19_27310	COG0165	Argininosuccinate lyase
VagYM19_27310	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VagYM19_27320	COG0137	argininosuccinate synthase activity
VagYM19_27340	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VagYM19_27360	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VagYM19_27380	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VagYM19_27390	COG0460	homoserine dehydrogenase
VagYM19_27390	COG0527	aspartate kinase activity
VagYM19_27400	COG0626	cystathionine gamma-synthase activity
VagYM19_27420	COG0281	malic enzyme
VagYM19_27440	COG2906	2 iron, 2 sulfur cluster binding
VagYM19_27450	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VagYM19_27460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VagYM19_27500	COG2923	Belongs to the DsrF TusC family
VagYM19_27510	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VagYM19_27520	COG2964	Protein conserved in bacteria
VagYM19_27530	COG0545	Peptidyl-prolyl cis-trans isomerase
VagYM19_27560	COG1446	asparaginase
VagYM19_27570	COG1047	Peptidyl-prolyl cis-trans
VagYM19_27600	COG2249	NAD(P)H dehydrogenase (quinone) activity
VagYM19_27610	COG0488	(ABC) transporter
VagYM19_27630	COG0429	hydrolase of the alpha beta-hydrolase fold
VagYM19_27640	COG3089	Belongs to the UPF0270 family
VagYM19_27650	COG3954	Phosphoribulokinase
VagYM19_27660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VagYM19_27700	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VagYM19_27710	COG0512	Glutamine amidotransferase of anthranilate synthase
VagYM19_27740	COG0180	Tryptophanyl-tRNA synthetase
VagYM19_27750	COG0546	phosphoglycolate phosphatase activity
VagYM19_27760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VagYM19_27770	COG0557	exoribonuclease II activity
VagYM19_27780	COG1959	2 iron, 2 sulfur cluster binding
VagYM19_27790	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VagYM19_27790	COG1017	nitric oxide dioxygenase activity
VagYM19_27800	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VagYM19_27810	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VagYM19_27820	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VagYM19_27830	COG0330	HflC and HflK could
VagYM19_27840	COG0330	HflC and HflK could
VagYM19_27850	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VagYM19_27870	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VagYM19_27880	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VagYM19_27900	COG0802	atpase or kinase
VagYM19_27910	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VagYM19_27920	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VagYM19_27930	COG1162	GTPase activity
VagYM19_27940	COG0688	phosphatidylethanolamine metabolic process
VagYM19_27950	COG3273	potassium ion transport
VagYM19_27950	COG0471	metal ion transport
VagYM19_27970	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VagYM19_27980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VagYM19_27990	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VagYM19_28000	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VagYM19_28010	COG1045	serine acetyltransferase
VagYM19_28020	COG4942	peptidase
VagYM19_28060	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VagYM19_28070	COG1053	succinate dehydrogenase
VagYM19_28080	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VagYM19_28090	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VagYM19_28130	COG1509	lysine 2,3-aminomutase activity
VagYM19_28140	COG1285	pathogenesis
VagYM19_28160	COG0459	protein refolding
VagYM19_28180	COG0534	Mate efflux family protein
VagYM19_28190	COG0205	6-phosphofructokinase activity
VagYM19_28200	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VagYM19_28220	COG0745	RESPONSE REGULATOR receiver
VagYM19_28230	COG2205	protein histidine kinase activity
VagYM19_28250	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VagYM19_28260	COG3030	protein affecting phage T7 exclusion by the F plasmid
VagYM19_28270	COG1027	Aspartate ammonia-lyase
VagYM19_28280	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VagYM19_28290	COG4232	protein-disulfide reductase activity
VagYM19_28310	COG3263	regulation of cellular component size
VagYM19_28330	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VagYM19_28380	COG2814	Major facilitator Superfamily
VagYM19_28410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VagYM19_28420	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VagYM19_28430	COG0511	ligase activity, forming carbon-carbon bonds
VagYM19_28440	COG0439	Biotin carboxylase
VagYM19_28450	COG2264	protein methyltransferase activity
VagYM19_28460	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VagYM19_28470	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VagYM19_28490	COG0488	(ABC) transporter
VagYM19_28500	COG1982	Orn Lys Arg decarboxylase major
VagYM19_28510	COG0531	amino acid
VagYM19_28530	COG3710	Transcriptional regulator
VagYM19_28540	COG0789	Transcriptional regulator
VagYM19_28550	COG0138	bifunctional purine biosynthesis protein purh
VagYM19_28560	COG0151	Belongs to the GarS family
VagYM19_28590	COG1253	flavin adenine dinucleotide binding
VagYM19_28600	COG3068	Protein conserved in bacteria
VagYM19_28620	COG1573	uracil-dna glycosylase
VagYM19_28630	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VagYM19_28640	COG2816	NAD+ diphosphatase activity
VagYM19_28650	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VagYM19_28660	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VagYM19_28670	COG0085	RNA polymerase activity
VagYM19_28680	COG0222	ribosome binding
VagYM19_28690	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VagYM19_28720	COG0250	Participates in transcription elongation, termination and antitermination
VagYM19_28730	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VagYM19_28740	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VagYM19_28760	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
VagYM19_28760	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
VagYM19_28770	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VagYM19_28790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VagYM19_28830	COG4206	TonB-dependent receptor
VagYM19_28870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VagYM19_28880	COG0534	Mate efflux family protein
VagYM19_28890	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
VagYM19_28900	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VagYM19_28910	COG2937	Belongs to the GPAT DAPAT family
VagYM19_28920	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VagYM19_28930	COG3161	chorismate lyase activity
VagYM19_28940	COG1580	Controls the rotational direction of flagella during chemotaxis
VagYM19_28950	COG0705	Rhomboid family
VagYM19_28960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VagYM19_28980	COG2177	Part of the ABC transporter FtsEX involved in
VagYM19_28990	COG2884	Cell division ATP-binding protein ftsE
VagYM19_29000	COG0552	protein localization to endoplasmic reticulum
VagYM19_29010	COG0742	ribosomal rna small subunit methyltransferase
VagYM19_29030	COG2095	MarC family integral membrane protein
VagYM19_29120	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VagYM19_29130	COG0640	Transcriptional regulator
VagYM19_29140	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VagYM19_29150	COG1280	lysine exporter protein (LysE YggA)
VagYM19_29160	COG2267	carboxylic ester hydrolase activity
VagYM19_29170	COG0561	phosphatase activity
VagYM19_29210	COG2200	EAL domain
VagYM19_29210	COG3287	FIST C domain
VagYM19_29210	COG2199	diguanylate cyclase activity
VagYM19_29220	COG1011	Hydrolase
VagYM19_29230	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VagYM19_29250	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VagYM19_29260	COG0019	diaminopimelate decarboxylase activity
VagYM19_29270	COG1965	Belongs to the frataxin family
VagYM19_29290	COG3072	Adenylate cyclase
VagYM19_29300	COG0181	hydroxymethylbilane synthase activity
VagYM19_29310	COG1587	Uroporphyrinogen-III synthase
VagYM19_29320	COG2959	enzyme of heme biosynthesis
VagYM19_29330	COG3071	HemY protein
VagYM19_29350	COG0633	Ferredoxin
VagYM19_29360	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VagYM19_29390	COG3118	belongs to the thioredoxin family
VagYM19_29400	COG0513	Belongs to the DEAD box helicase family
VagYM19_29410	COG0248	Ppx GppA phosphatase
VagYM19_29420	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VagYM19_29440	COG0514	ATP-dependent DNA helicase (RecQ)
VagYM19_29450	COG2962	Rard protein
VagYM19_29470	COG1280	lysine exporter protein (LysE YggA)
VagYM19_29480	COG0405	Gamma-glutamyltransferase
VagYM19_29500	COG0210	DNA helicase
VagYM19_29520	COG3220	belongs to the UPF0276 family
VagYM19_29580	COG0006	proline dipeptidase activity
VagYM19_29580	COG0006	proline dipeptidase activity
VagYM19_29620	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VagYM19_29650	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VagYM19_29660	COG2132	Multicopper oxidase
VagYM19_29670	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VagYM19_29690	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VagYM19_29700	COG0408	coproporphyrinogen oxidase activity
VagYM19_29710	COG0009	L-threonylcarbamoyladenylate synthase
VagYM19_29720	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VagYM19_29730	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VagYM19_29740	COG0551	DNA topoisomerase type I activity
VagYM19_29750	COG2922	Belongs to the Smg family
VagYM19_29760	COG0758	DNA mediated transformation
VagYM19_29780	COG0242	peptide deformylase activity
VagYM19_29790	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VagYM19_29800	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VagYM19_29800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VagYM19_29810	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VagYM19_29810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VagYM19_29820	COG0569	domain protein
VagYM19_29830	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VagYM19_29850	COG1272	protein, Hemolysin III
VagYM19_29860	COG4326	sporulation control protein
VagYM19_29880	COG3084	Protein conserved in bacteria
VagYM19_29900	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VagYM19_29910	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VagYM19_29920	COG0204	Acyl-transferase
VagYM19_29940	COG0606	chelatase, subunit chli
VagYM19_29960	COG3978	acetolactate synthase activity
VagYM19_29970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VagYM19_29980	COG0129	dihydroxy-acid dehydratase activity
VagYM19_30000	COG0583	DNA-binding transcription factor activity
VagYM19_30010	COG2814	Major facilitator Superfamily
VagYM19_30030	COG0765	amino acid transport
VagYM19_30050	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VagYM19_30060	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VagYM19_30070	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VagYM19_30080	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VagYM19_30090	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VagYM19_30100	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VagYM19_30120	COG0356	it plays a direct role in the translocation of protons across the membrane
VagYM19_30130	COG3312	ion transport
VagYM19_30140	COG1475	DNA binding
VagYM19_30150	COG1192	Involved in chromosome partitioning
VagYM19_30160	COG0357	Ribosomal RNA small subunit methyltransferase G
VagYM19_30170	COG0445	tRNA wobble uridine modification
VagYM19_30180	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VagYM19_30200	COG3706	GGDEF domain
VagYM19_30230	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VagYM19_30240	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VagYM19_30260	COG1609	Transcriptional regulator
VagYM19_30470	COG4974	Belongs to the 'phage' integrase family
VagYM19_30490	COG0706	membrane insertase activity
VagYM19_30500	COG0594	ribonuclease P activity
VagYM19_30520	COG1126	abc transporter atp-binding protein
VagYM19_30570	COG4608	Belongs to the ABC transporter superfamily
VagYM19_30580	COG0444	Belongs to the ABC transporter superfamily
VagYM19_30600	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VagYM19_30600	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
VagYM19_30650	COG0772	Belongs to the SEDS family
VagYM19_30670	COG1136	(ABC) transporter
VagYM19_30710	COG3275	phosphorelay sensor kinase activity
VagYM19_30720	COG3279	Response regulator of the LytR AlgR family
VagYM19_30740	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VagYM19_30780	COG0786	glutamate:sodium symporter activity
VagYM19_30800	COG1131	(ABC) transporter
VagYM19_30810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VagYM19_30820	COG0786	glutamate:sodium symporter activity
VagYM19_30840	COG0363	glucosamine-6-phosphate deaminase activity
VagYM19_30880	COG1741	Belongs to the pirin family
VagYM19_30890	COG2259	Doxx family
VagYM19_30910	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
VagYM19_30920	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VagYM19_30940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VagYM19_31000	COG0596	Alpha beta hydrolase
VagYM19_31030	COG3123	guanosine phosphorylase activity
VagYM19_31060	COG0534	Mate efflux family protein
VagYM19_31070	COG0564	pseudouridine synthase activity
VagYM19_31100	COG0583	DNA-binding transcription factor activity
VagYM19_31110	COG0561	phosphatase activity
VagYM19_31130	COG2199	diguanylate cyclase activity
VagYM19_31160	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
VagYM19_31170	COG2162	N-hydroxyarylamine O-acetyltransferase activity
VagYM19_31180	COG0583	DNA-binding transcription factor activity
VagYM19_31260	COG1357	PFAM Pentapeptide repeats (8 copies)
VagYM19_31270	COG3047	cAMP biosynthetic process
VagYM19_31330	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
VagYM19_31330	COG3408	Glycogen debranching enzyme
VagYM19_31340	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
VagYM19_31380	COG0583	DNA-binding transcription factor activity
VagYM19_31410	COG0546	phosphoglycolate phosphatase activity
VagYM19_31460	COG3835	regulator
VagYM19_31470	COG2610	gluconate transmembrane transporter activity
VagYM19_31480	COG1929	Belongs to the glycerate kinase type-1 family
VagYM19_31490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VagYM19_31530	COG0456	acetyltransferase
VagYM19_31560	COG1028	Short-chain dehydrogenase reductase Sdr
VagYM19_31570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VagYM19_31580	COG3005	denitrification pathway
VagYM19_31590	COG0243	molybdopterin cofactor binding
VagYM19_31610	COG0352	thiamine-phosphate diphosphorylase activity
VagYM19_31620	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
VagYM19_31630	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
VagYM19_31640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VagYM19_31650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VagYM19_31660	COG1116	anion transmembrane transporter activity
VagYM19_31670	COG0351	phosphomethylpyrimidine kinase
VagYM19_31680	COG0312	modulator of DNA gyrase
VagYM19_31690	COG0312	modulator of DNA gyrase
VagYM19_31700	COG1901	pseudouridine methyltransferase
VagYM19_31750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VagYM19_31770	COG0584	glycerophosphoryl diester phosphodiesterase
VagYM19_31780	COG0039	L-malate dehydrogenase activity
VagYM19_31790	COG0745	RESPONSE REGULATOR receiver
VagYM19_31830	COG0811	peptide transport
VagYM19_31840	COG0811	peptide transport
VagYM19_31850	COG0848	biopolymer transport protein
VagYM19_31940	COG0803	Belongs to the bacterial solute-binding protein 9 family
VagYM19_31950	COG1121	(ABC) transporter
VagYM19_31960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VagYM19_31990	COG1770	oligopeptidase
VagYM19_32000	COG2814	Major facilitator Superfamily
VagYM19_32010	COG0010	Belongs to the arginase family
VagYM19_32020	COG1166	arginine decarboxylase activity
VagYM19_32040	COG4067	protein conserved in archaea
VagYM19_32040	COG0189	ligase activity
VagYM19_32050	COG0189	ligase activity
VagYM19_32060	COG0583	DNA-binding transcription factor activity
VagYM19_32130	COG4191	Histidine kinase
VagYM19_32140	COG2204	response regulator
VagYM19_32150	COG3706	GGDEF domain
VagYM19_32190	COG0579	oxidoreductase
VagYM19_32210	COG1294	oxidase, subunit
VagYM19_32220	COG1271	oxidase subunit
VagYM19_32240	COG3033	Beta-eliminating lyase
VagYM19_32260	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VagYM19_32290	COG3706	GGDEF domain
VagYM19_32320	COG3706	GGDEF domain
VagYM19_32330	COG0415	Belongs to the DNA photolyase family
VagYM19_32340	COG3046	protein related to deoxyribodipyrimidine photolyase
VagYM19_32360	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VagYM19_32360	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VagYM19_32370	COG1765	OsmC-like protein
VagYM19_32380	COG0110	maltose O-acetyltransferase activity
VagYM19_32460	COG1011	Hydrolase
VagYM19_32490	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VagYM19_32500	COG3338	carbonate dehydratase activity
VagYM19_32510	COG2067	long-chain fatty acid transport protein
VagYM19_32520	COG3240	lipase activity
VagYM19_32580	COG1609	Transcriptional regulator
VagYM19_32590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VagYM19_32620	COG1840	ABC-type Fe3 transport system, periplasmic component
VagYM19_32630	COG3842	ATPase activity
VagYM19_32680	COG2990	Protein conserved in bacteria
VagYM19_32700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VagYM19_32710	COG2866	Carboxypeptidase
VagYM19_32730	COG0583	DNA-binding transcription factor activity
VagYM19_32770	COG3104	oligopeptide transport
VagYM19_32780	COG1760	l-serine dehydratase
VagYM19_32820	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VagYM19_32830	COG0741	lytic transglycosylase activity
VagYM19_32870	COG1815	bacterial-type flagellum-dependent cell motility
VagYM19_32880	COG1558	bacterial-type flagellum-dependent cell motility
VagYM19_32890	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
VagYM19_32900	COG1749	Flagellar hook protein flgE
VagYM19_32910	COG4787	bacterial-type flagellum-dependent cell motility
VagYM19_32920	COG4786	Flagellar basal body rod
VagYM19_32930	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VagYM19_32940	COG1706	bacterial-type flagellum-dependent cell motility
VagYM19_32960	COG4786	Flagellar basal body rod
VagYM19_32960	COG1256	bacterial-type flagellum assembly
VagYM19_32970	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VagYM19_33010	COG1304	FMN binding
VagYM19_33040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VagYM19_33050	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VagYM19_33060	COG0459	protein refolding
VagYM19_33090	COG1280	lysine exporter protein (LysE YggA)
VagYM19_33130	COG1309	transcriptional regulator
VagYM19_33150	COG4303	Ethanolamine ammonia lyase large subunit
VagYM19_33160	COG4302	ethanolamine ammonia-lyase activity
VagYM19_33170	COG0531	amino acid
VagYM19_33180	COG2070	2-Nitropropane dioxygenase
VagYM19_33190	COG3537	Alpha-1,2-mannosidase
VagYM19_33200	COG3537	Alpha-1,2-mannosidase
VagYM19_33220	COG3537	Alpha-1,2-mannosidase
VagYM19_33230	COG3537	Alpha-1,2-mannosidase
VagYM19_33240	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VagYM19_33260	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VagYM19_33260	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VagYM19_33270	COG0346	lactoylglutathione lyase activity
VagYM19_33280	COG1349	DNA-binding transcription factor activity
VagYM19_33300	COG1335	isochorismatase
VagYM19_33320	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
VagYM19_33370	COG0583	DNA-binding transcription factor activity
VagYM19_33400	COG3713	MltA-interacting MipA family protein
VagYM19_33410	COG3015	lipoprotein NlpE involved in copper resistance
VagYM19_33420	COG3448	diguanylate cyclase activity
VagYM19_33420	COG4175	Glycine betaine
VagYM19_33430	COG4176	ABC-type proline glycine betaine transport system permease component
VagYM19_33440	COG1342	Belongs to the UPF0251 family
VagYM19_33500	COG4948	Mandelate Racemase Muconate Lactonizing
VagYM19_33520	COG0583	DNA-binding transcription factor activity
VagYM19_33590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VagYM19_33660	COG3842	ATPase activity
VagYM19_33720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VagYM19_33780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VagYM19_33810	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VagYM19_33820	COG2197	response regulator
VagYM19_33850	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
VagYM19_33860	COG0252	asparaginase activity
VagYM19_33880	COG0583	DNA-binding transcription factor activity
VagYM19_33900	COG1280	lysine exporter protein (LysE YggA)
VagYM19_33910	COG3122	Protein conserved in bacteria
VagYM19_33930	COG2423	ornithine cyclodeaminase activity
VagYM19_33940	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
VagYM19_33950	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VagYM19_33960	COG1012	belongs to the aldehyde dehydrogenase family
VagYM19_33970	COG1522	sequence-specific DNA binding
VagYM19_33980	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VagYM19_33990	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VagYM19_34000	COG3608	succinylglutamate desuccinylase aspartoacylase
VagYM19_34010	COG0006	proline dipeptidase activity
VagYM19_34020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VagYM19_34030	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VagYM19_34040	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VagYM19_34050	COG2207	Transcriptional regulator
VagYM19_34060	COG1028	Short-chain dehydrogenase reductase Sdr
VagYM19_34080	COG1063	alcohol dehydrogenase
VagYM19_34090	COG1902	pentaerythritol trinitrate reductase activity
VagYM19_34120	COG0583	DNA-binding transcription factor activity
VagYM19_34140	COG0513	Belongs to the DEAD box helicase family
VagYM19_34180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VagYM19_34190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VagYM19_34190	COG2207	Transcriptional regulator
VagYM19_34240	COG3746	phosphate-selective porin O and P
VagYM19_34270	COG1028	Short-chain dehydrogenase reductase Sdr
VagYM19_34330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VagYM19_34330	COG1263	PTS System
VagYM19_34340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VagYM19_34350	COG1621	beta-fructofuranosidase activity
VagYM19_34360	COG0625	glutathione transferase activity
VagYM19_34380	COG1686	Belongs to the peptidase S11 family
VagYM19_34410	COG0678	peroxiredoxin activity
VagYM19_34410	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VagYM19_34420	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VagYM19_34430	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VagYM19_34460	COG1278	Cold shock
VagYM19_34470	COG1741	Belongs to the pirin family
VagYM19_34480	COG4667	esterase of the alpha-beta hydrolase superfamily
VagYM19_34530	COG2194	sulfuric ester hydrolase activity
VagYM19_34540	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VagYM19_34560	COG2205	protein histidine kinase activity
VagYM19_34570	COG0745	RESPONSE REGULATOR receiver
VagYM19_34600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VagYM19_34640	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VagYM19_34660	COG2814	Major facilitator Superfamily
VagYM19_34680	COG1418	mRNA catabolic process
VagYM19_34690	COG0402	S-adenosylhomocysteine deaminase activity
VagYM19_34700	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
VagYM19_34710	COG2239	Acts as a magnesium transporter
VagYM19_34720	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VagYM19_34730	COG1566	PFAM secretion protein HlyD family protein
VagYM19_34780	COG0745	RESPONSE REGULATOR receiver
VagYM19_34790	COG2205	protein histidine kinase activity
VagYM19_34820	COG0531	amino acid
VagYM19_34840	COG0583	DNA-binding transcription factor activity
VagYM19_34890	COG5002	protein histidine kinase activity
VagYM19_34890	COG0784	Response regulator, receiver
VagYM19_34890	COG2205	protein histidine kinase activity
VagYM19_34900	COG0534	Mate efflux family protein
VagYM19_34930	COG3132	Protein of unknown function, DUF480
VagYM19_34940	COG2827	Endonuclease containing a URI domain
VagYM19_34950	COG1879	ABC-type sugar transport system periplasmic component
VagYM19_34960	COG0784	Response regulator, receiver
VagYM19_34960	COG2205	protein histidine kinase activity
VagYM19_35070	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VagYM19_35080	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VagYM19_35100	COG1280	lysine exporter protein (LysE YggA)
VagYM19_35120	COG0183	Belongs to the thiolase family
VagYM19_35140	COG3243	poly(R)-hydroxyalkanoic acid synthase
VagYM19_35160	COG3005	denitrification pathway
VagYM19_35180	COG0243	molybdopterin cofactor binding
VagYM19_35200	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VagYM19_35210	COG3850	Histidine kinase
VagYM19_35220	COG2197	response regulator
VagYM19_35250	COG2195	Cleaves the N-terminal amino acid of tripeptides
VagYM19_35290	COG0840	transmembrane signaling receptor activity
VagYM19_35310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VagYM19_35330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VagYM19_35340	COG2814	Major facilitator Superfamily
VagYM19_35350	COG0840	transmembrane signaling receptor activity
VagYM19_35360	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VagYM19_35370	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VagYM19_35410	COG2897	thiosulfate sulfurtransferase activity
VagYM19_35450	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VagYM19_35480	COG1914	H( )-stimulated, divalent metal cation uptake system
VagYM19_35500	COG0038	chloride channel
VagYM19_35530	COG4989	oxidoreductase activity
VagYM19_35560	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
VagYM19_35560	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
VagYM19_35580	COG1013	pyruvate-flavodoxin oxidoreductase activity
VagYM19_35590	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
VagYM19_35590	COG0674	pyruvate-flavodoxin oxidoreductase activity
VagYM19_35610	COG0739	heme binding
VagYM19_35700	COG3501	Rhs element vgr protein
VagYM19_35750	COG0515	serine threonine protein kinase
VagYM19_35820	COG1522	sequence-specific DNA binding
VagYM19_35960	COG2814	Major facilitator Superfamily
VagYM19_35980	COG0583	DNA-binding transcription factor activity
VagYM19_35990	COG4221	oxidoreductase activity
VagYM19_36000	COG0589	response to stress
VagYM19_36020	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VagYM19_36020	COG2111	Na H antiporter
VagYM19_36060	COG2212	antiporter activity
VagYM19_36070	COG1320	monovalent cation:proton antiporter activity
VagYM19_36080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VagYM19_36210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VagYM19_36240	COG3527	Alpha-acetolactate decarboxylase
VagYM19_36300	COG0384	phenazine biosynthesis protein PhzF
VagYM19_36320	COG1294	oxidase, subunit
VagYM19_36330	COG1271	oxidase subunit
VagYM19_36340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VagYM19_36380	COG4999	Histidine kinase
VagYM19_36380	COG3850	Histidine kinase
VagYM19_36380	COG2205	protein histidine kinase activity
VagYM19_36380	COG3437	response regulator, receiver
VagYM19_36400	COG4770	biotin carboxylase activity
VagYM19_36420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VagYM19_36430	COG1960	acyl-CoA dehydrogenase activity
VagYM19_36450	COG0183	Belongs to the thiolase family
VagYM19_36470	COG1960	acyl-CoA dehydrogenase activity
VagYM19_36480	COG1024	Enoyl-CoA hydratase
VagYM19_36510	COG1028	Short-chain dehydrogenase reductase Sdr
VagYM19_36530	COG1309	transcriptional regulator
VagYM19_36540	COG1012	belongs to the aldehyde dehydrogenase family
VagYM19_36570	COG4176	ABC-type proline glycine betaine transport system permease component
VagYM19_36580	COG4175	Glycine betaine
VagYM19_36580	COG0517	IMP dehydrogenase activity
VagYM19_36610	COG0330	HflC and HflK could
VagYM19_36640	COG3300	MHYT domain
VagYM19_36640	COG5001	Diguanylate cyclase
VagYM19_36670	COG0784	Response regulator, receiver
VagYM19_36670	COG2205	protein histidine kinase activity
VagYM19_36690	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
VagYM19_36780	COG5001	Diguanylate cyclase
VagYM19_36790	COG1869	D-ribose catabolic process
VagYM19_36800	COG1129	ABC transporter
VagYM19_36810	COG1172	Belongs to the binding-protein-dependent transport system permease family
VagYM19_36820	COG1879	ABC-type sugar transport system periplasmic component
VagYM19_36830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VagYM19_36840	COG1609	Transcriptional regulator
VagYM19_36870	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VagYM19_36890	COG4607	ABC-type enterochelin transport system periplasmic component
VagYM19_36900	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VagYM19_36910	COG4605	iron ion homeostasis
VagYM19_36920	COG4604	ABC transporter, ATP-binding protein
VagYM19_36930	COG0789	Transcriptional regulator
VagYM19_36940	COG2207	Transcriptional regulator
VagYM19_36950	COG4771	TonB-dependent receptor
VagYM19_36950	COG1629	transport
VagYM19_37010	COG1289	transmembrane transporter activity
VagYM19_37020	COG0210	DNA helicase
VagYM19_37030	COG1803	Methylglyoxal synthase
VagYM19_37040	COG1879	ABC-type sugar transport system periplasmic component
VagYM19_37050	COG2198	Histidine kinase
VagYM19_37050	COG0784	Response regulator, receiver
VagYM19_37050	COG2205	protein histidine kinase activity
VagYM19_37090	COG3119	arylsulfatase activity
VagYM19_37110	COG3119	arylsulfatase activity
VagYM19_37120	COG0641	radical SAM
VagYM19_37130	COG0714	Associated with various cellular activities
VagYM19_37190	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VagYM19_37190	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VagYM19_37200	COG0583	DNA-binding transcription factor activity
VagYM19_37210	COG1597	lipid kinase activity
VagYM19_37220	COG3111	PFAM Bacterial OB fold (BOF) protein
VagYM19_37280	COG0501	Belongs to the peptidase M48B family
VagYM19_37290	COG1704	LemA family
VagYM19_37300	COG3069	C4-dicarboxylate transmembrane transporter activity
VagYM19_37320	COG0456	acetyltransferase
VagYM19_37320	COG1214	PFAM Peptidase M22, glycoprotease
VagYM19_37360	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
VagYM19_37380	COG3706	GGDEF domain
VagYM19_37400	COG2197	response regulator
VagYM19_37410	COG0835	chemotaxis
VagYM19_37410	COG0784	Response regulator, receiver
VagYM19_37440	COG2962	Rard protein
VagYM19_37540	COG0471	metal ion transport
VagYM19_37550	COG3290	protein histidine kinase activity
VagYM19_37560	COG4565	transcriptional regulatory protein
VagYM19_37590	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
VagYM19_37600	COG5642	Protein of unknown function (DUF2384)
VagYM19_37620	COG2755	lipolytic protein G-D-S-L family
VagYM19_37620	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
VagYM19_37640	COG1902	pentaerythritol trinitrate reductase activity
VagYM19_37650	COG0346	lactoylglutathione lyase activity
VagYM19_37690	COG2239	Acts as a magnesium transporter
VagYM19_37730	COG0242	peptide deformylase activity
VagYM19_37810	COG2176	DNA-directed DNA polymerase activity
VagYM19_37870	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VagYM19_37880	COG0346	lactoylglutathione lyase activity
VagYM19_37950	COG1979	alcohol dehydrogenase
VagYM19_37960	COG2207	Transcriptional regulator
VagYM19_37980	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VagYM19_37990	COG2759	Belongs to the formate--tetrahydrofolate ligase family
VagYM19_38000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VagYM19_38040	COG0546	phosphoglycolate phosphatase activity
VagYM19_38050	COG0840	transmembrane signaling receptor activity
VagYM19_38080	COG0513	Belongs to the DEAD box helicase family
VagYM19_38090	COG4943	cyclic-guanylate-specific phosphodiesterase activity
VagYM19_38120	COG3038	cytochrome b561
VagYM19_38130	COG2353	YceI-like domain
VagYM19_38140	COG2116	formate transmembrane transporter activity
VagYM19_38150	COG0583	DNA-binding transcription factor activity
VagYM19_38170	COG3593	DNA synthesis involved in DNA repair
VagYM19_38180	COG0737	Belongs to the 5'-nucleotidase family
VagYM19_38240	COG2267	carboxylic ester hydrolase activity
VagYM19_38250	COG2067	long-chain fatty acid transport protein
VagYM19_38280	COG2050	protein possibly involved in aromatic compounds catabolism
VagYM19_38300	COG4533	DNA binding
VagYM19_38370	COG5001	Diguanylate cyclase
VagYM19_38370	COG1716	ATPase activity
VagYM19_38380	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VagYM19_38400	COG4181	ATPase activity
VagYM19_38410	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
VagYM19_38430	COG1984	allophanate hydrolase subunit 2
VagYM19_38440	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
VagYM19_38450	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VagYM19_38460	COG3447	MASE1 domain protein
VagYM19_38460	COG5002	protein histidine kinase activity
VagYM19_38460	COG5001	Diguanylate cyclase
VagYM19_38470	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VagYM19_38490	COG0583	DNA-binding transcription factor activity
VagYM19_38500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VagYM19_38500	COG0045	succinate-CoA ligase (ADP-forming) activity
VagYM19_38500	COG1042	CoA-binding domain protein
VagYM19_38520	COG1181	Belongs to the D-alanine--D-alanine ligase family
VagYM19_38540	COG0023	Translation Initiation Factor
VagYM19_38560	COG4128	Pfam Zonular occludens toxin
VagYM19_38660	COG4128	Pfam Zonular occludens toxin
VagYM19_38780	COG0583	DNA-binding transcription factor activity
VagYM19_38800	COG0589	response to stress
VagYM19_38810	COG3140	Belongs to the UPF0181 family
VagYM19_38860	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VagYM19_38870	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VagYM19_38920	COG5001	Diguanylate cyclase
VagYM19_38920	COG2203	Gaf domain
VagYM19_38920	COG4251	negative regulation of phosphorylation
VagYM19_38920	COG3706	GGDEF domain
VagYM19_38940	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
VagYM19_38950	COG4149	molybdate abc transporter
VagYM19_38960	COG0725	ABC transporter, periplasmic molybdate-binding protein
VagYM19_39000	COG4067	protein conserved in archaea
VagYM19_39000	COG0189	ligase activity
VagYM19_39020	COG2207	Transcriptional regulator
VagYM19_39030	COG0534	Mate efflux family protein
VagYM19_39040	COG0602	queuosine metabolic process
VagYM19_39050	COG1328	CTP reductase activity
VagYM19_39080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VagYM19_39140	COG1794	racemase activity, acting on amino acids and derivatives
VagYM19_39150	COG0384	phenazine biosynthesis protein PhzF
VagYM19_39170	COG0243	molybdopterin cofactor binding
VagYM19_39180	COG0583	DNA-binding transcription factor activity
VagYM19_39190	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VagYM19_39210	COG2197	response regulator
VagYM19_39220	COG3851	Histidine kinase
VagYM19_39230	COG2271	Major facilitator Superfamily
VagYM19_39280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VagYM19_39290	COG3118	belongs to the thioredoxin family
VagYM19_39360	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VagYM19_39400	COG2116	formate transmembrane transporter activity
VagYM19_39420	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VagYM19_39430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VagYM19_39440	COG5001	Diguanylate cyclase
VagYM19_39540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VagYM19_39610	COG0277	FAD linked oxidase domain protein
VagYM19_39620	COG0583	DNA-binding transcription factor activity
VagYM19_39630	COG2425	protein containing a von Willebrand factor type A (vWA) domain
VagYM19_39660	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
VagYM19_39680	COG1288	antiporter activity
VagYM19_39700	COG3040	lipid binding
VagYM19_39720	COG0419	ATPase involved in DNA repair
VagYM19_39730	COG0420	3'-5' exonuclease activity
VagYM19_39760	COG3501	Rhs element vgr protein
VagYM19_39870	COG0631	protein serine/threonine phosphatase activity
VagYM19_39940	COG2815	serine threonine protein kinase
VagYM19_39940	COG0515	serine threonine protein kinase
VagYM19_39980	COG0745	RESPONSE REGULATOR receiver
VagYM19_40040	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VagYM19_40040	COG2146	nitrite reductase [NAD(P)H] activity
VagYM19_40050	COG1116	anion transmembrane transporter activity
VagYM19_40060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VagYM19_40070	COG1116	anion transmembrane transporter activity
VagYM19_40070	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VagYM19_40120	COG0243	molybdopterin cofactor binding
VagYM19_40140	COG0814	amino acid
VagYM19_40160	COG3706	GGDEF domain
VagYM19_40260	COG2847	Copper chaperone PCu(A)C
VagYM19_40270	COG0443	Heat shock 70 kDa protein
VagYM19_40400	COG4160	amino acid transport
VagYM19_40410	COG4215	(ABC) transporter
VagYM19_40420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VagYM19_40430	COG1126	abc transporter atp-binding protein
VagYM19_40490	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VagYM19_40510	COG1012	belongs to the aldehyde dehydrogenase family
VagYM19_40550	COG0446	pyridine nucleotide-disulphide oxidoreductase
VagYM19_40550	COG1902	pentaerythritol trinitrate reductase activity
VagYM19_40570	COG0109	protoheme IX farnesyltransferase activity
VagYM19_40580	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
VagYM19_40590	COG1845	cytochrome c oxidase, subunit III
VagYM19_40600	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VagYM19_40610	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VagYM19_40620	COG1028	Short-chain dehydrogenase reductase Sdr
VagYM19_40640	COG1024	Enoyl-CoA hydratase
VagYM19_40650	COG1024	Enoyl-CoA hydratase
VagYM19_40680	COG0183	Belongs to the thiolase family
VagYM19_40700	COG1960	acyl-CoA dehydrogenase activity
VagYM19_40710	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VagYM19_40720	COG1024	Enoyl-CoA hydratase
VagYM19_40740	COG5413	integral membrane protein
VagYM19_40760	COG0277	FAD linked oxidase domain protein
VagYM19_40760	COG0247	lactate metabolic process
VagYM19_40870	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VagYM19_40890	COG0513	Belongs to the DEAD box helicase family
VagYM19_40900	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
VagYM19_40950	COG0840	transmembrane signaling receptor activity
VagYM19_40960	COG1119	ATPase activity
VagYM19_40970	COG2200	EAL domain
VagYM19_41020	COG0513	Belongs to the DEAD box helicase family
VagYM19_41030	COG0523	cobalamin synthesis protein
VagYM19_41050	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
VagYM19_41070	COG1278	Cold shock
VagYM19_41080	COG0557	exoribonuclease II activity
VagYM19_41090	COG0133	tryptophan synthase activity
VagYM19_41110	COG4628	conserved protein (DUF2132)
VagYM19_41120	COG0513	Belongs to the DEAD box helicase family
VagYM19_41140	COG0730	response to heat
VagYM19_41170	COG0697	spore germination
VagYM19_41180	COG1982	Orn Lys Arg decarboxylase major
VagYM19_41190	COG1335	isochorismatase
VagYM19_41210	COG1404	Belongs to the peptidase S8 family
VagYM19_41240	COG3530	Putative quorum-sensing-regulated virulence factor
VagYM19_41290	COG3186	Phenylalanine-4-hydroxylase
VagYM19_41300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VagYM19_41310	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VagYM19_41360	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
VagYM19_41370	COG1454	alcohol dehydrogenase
VagYM19_41380	COG2133	pyrroloquinoline quinone binding
VagYM19_41400	COG0783	Belongs to the Dps family
VagYM19_41410	COG0840	transmembrane signaling receptor activity
VagYM19_41430	COG0577	efflux transmembrane transporter activity
VagYM19_41430	COG1136	(ABC) transporter
VagYM19_41470	COG2199	diguanylate cyclase activity
VagYM19_41480	COG3036	rescue of stalled ribosome
VagYM19_41490	COG1278	Cold shock
VagYM19_41530	COG2885	chlorophyll binding
VagYM19_41550	COG0545	Peptidyl-prolyl cis-trans isomerase
VagYM19_41560	COG0109	protoheme IX farnesyltransferase activity
VagYM19_41570	COG1612	heme a metabolic process
VagYM19_41610	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
VagYM19_41620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VagYM19_41630	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VagYM19_41640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VagYM19_41660	COG1280	lysine exporter protein (LysE YggA)
VagYM19_41670	COG2207	Transcriptional regulator
VagYM19_41700	COG0179	Fumarylacetoacetate (FAA) hydrolase
VagYM19_41740	COG0697	spore germination
VagYM19_41780	COG2814	Major facilitator Superfamily
VagYM19_41790	COG0583	DNA-binding transcription factor activity
VagYM19_41800	COG5001	Diguanylate cyclase
VagYM19_41810	COG0739	heme binding
VagYM19_41870	COG0840	transmembrane signaling receptor activity
VagYM19_41890	COG0814	amino acid
VagYM19_41920	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
VagYM19_41930	COG1072	(Pantothenic acid kinase))
VagYM19_41950	COG1063	alcohol dehydrogenase
VagYM19_41960	COG2213	PTS system mannitol-specific
VagYM19_41970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VagYM19_42000	COG0798	PFAM Bile acid sodium symporter
VagYM19_42020	COG1881	PFAM PEBP family protein
VagYM19_42040	COG2706	6-phosphogluconolactonase activity
VagYM19_42060	COG1131	(ABC) transporter
VagYM19_42070	COG0842	Transport permease protein
VagYM19_42100	COG3383	formate dehydrogenase (NAD+) activity
VagYM19_42140	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VagYM19_42200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VagYM19_42220	COG2067	long-chain fatty acid transport protein
VagYM19_42240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VagYM19_42270	COG1505	serine-type exopeptidase activity
VagYM19_42280	COG0488	(ABC) transporter
VagYM19_42290	COG0589	response to stress
VagYM19_42300	COG2249	NAD(P)H dehydrogenase (quinone) activity
VagYM19_42340	COG0366	Alpha amylase catalytic
VagYM19_42350	COG0789	Transcriptional regulator
VagYM19_42380	COG4934	collagen metabolic process
VagYM19_42400	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VagYM19_42410	COG0583	DNA-binding transcription factor activity
VagYM19_42480	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VagYM19_42490	COG0835	chemotaxis
VagYM19_42490	COG0784	Response regulator, receiver
VagYM19_42510	COG0748	coenzyme F420 binding
VagYM19_42520	COG3721	Heme iron utilization protein
VagYM19_42540	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VagYM19_42550	COG0811	peptide transport
VagYM19_42560	COG0848	biopolymer transport protein
VagYM19_42580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VagYM19_42590	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VagYM19_42680	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VagYM19_42690	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VagYM19_42700	COG0633	Ferredoxin
VagYM19_42700	COG0633	Ferredoxin
VagYM19_42700	COG3217	Mosc domain protein beta barrel domain protein
VagYM19_42700	COG3217	Mosc domain protein beta barrel domain protein
VagYM19_42710	COG0401	homolog of Blt101
VagYM19_42720	COG0418	dihydroorotase activity
VagYM19_42730	COG2354	Protein conserved in bacteria
VagYM19_42790	COG3833	ABC-type maltose transport systems, permease component
VagYM19_42800	COG1175	transmembrane transport
VagYM19_42820	COG3842	ATPase activity
VagYM19_42830	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VagYM19_42950	COG1309	transcriptional regulator
VagYM19_42960	COG2130	NADP-dependent
VagYM19_42980	COG0753	catalase activity
VagYM19_42990	COG2084	Dehydrogenase
VagYM19_43000	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VagYM19_43010	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VagYM19_43030	COG2207	Transcriptional regulator
VagYM19_43040	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VagYM19_43040	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VagYM19_43040	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VagYM19_43070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VagYM19_43080	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
VagYM19_43090	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VagYM19_43110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VagYM19_43120	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VagYM19_43130	COG1012	belongs to the aldehyde dehydrogenase family
VagYM19_43160	COG0583	DNA-binding transcription factor activity
VagYM19_43170	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VagYM19_43180	COG0569	domain protein
VagYM19_43200	COG2205	protein histidine kinase activity
VagYM19_43200	COG2205	protein histidine kinase activity
VagYM19_43210	COG1132	(ABC) transporter
VagYM19_43220	COG4774	siderophore transport
VagYM19_43230	COG1120	ATPase activity
VagYM19_43240	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
VagYM19_43310	COG2197	response regulator
VagYM19_43330	COG0840	transmembrane signaling receptor activity
VagYM19_43340	COG0714	Associated with various cellular activities
VagYM19_43370	COG2304	oxidoreductase activity
VagYM19_43380	COG2304	oxidoreductase activity
VagYM19_43410	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VagYM19_43420	COG0581	inorganic phosphate transmembrane transporter activity
VagYM19_43430	COG0573	inorganic phosphate transmembrane transporter activity
VagYM19_43490	COG4771	TonB-dependent receptor
VagYM19_43500	COG1770	oligopeptidase
VagYM19_43510	COG0513	Belongs to the DEAD box helicase family
VagYM19_43530	COG1388	LysM domain
VagYM19_43530	COG1376	ErfK ybiS ycfS ynhG family protein
VagYM19_43540	COG0415	Belongs to the DNA photolyase family
VagYM19_43550	COG0789	Transcriptional regulator
VagYM19_43560	COG3272	Protein of unknown function (DUF1722)
VagYM19_43570	COG0813	purine-nucleoside phosphorylase activity
VagYM19_43600	COG3706	GGDEF domain
VagYM19_43620	COG1566	PFAM secretion protein HlyD family protein
VagYM19_43630	COG4720	Psort location CytoplasmicMembrane, score
VagYM19_43640	COG1122	ATPase activity
VagYM19_43680	COG0348	domain, Protein
VagYM19_43690	COG0437	4 iron, 4 sulfur cluster binding
VagYM19_43700	COG1247	-acetyltransferase
VagYM19_43740	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VagYM19_43750	COG0840	transmembrane signaling receptor activity
VagYM19_43760	COG1067	ATP-dependent peptidase activity
VagYM19_43780	COG4172	Belongs to the ABC transporter superfamily
VagYM19_43790	COG1505	serine-type exopeptidase activity
VagYM19_43800	COG0583	DNA-binding transcription factor activity
VagYM19_43810	COG1620	l-lactate permease
VagYM19_43820	COG1304	FMN binding
VagYM19_43840	COG0668	transmembrane transport
VagYM19_43860	COG1063	alcohol dehydrogenase
VagYM19_43870	COG0156	8-amino-7-oxononanoate synthase activity
VagYM19_43880	COG3300	MHYT domain
VagYM19_43880	COG5001	Diguanylate cyclase
VagYM19_43890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VagYM19_43930	COG0745	RESPONSE REGULATOR receiver
VagYM19_43980	COG0346	lactoylglutathione lyase activity
VagYM19_44090	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VagYM19_44170	COG1987	bacterial-type flagellum assembly
VagYM19_44190	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
VagYM19_44220	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VagYM19_44260	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VagYM19_44270	COG1516	flagellar protein fliS
VagYM19_44300	COG1580	Controls the rotational direction of flagella during chemotaxis
VagYM19_44310	COG1191	sigma factor activity
VagYM19_44320	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VagYM19_44330	COG1360	Flagellar Motor Protein
VagYM19_44430	COG1882	Formate acetyltransferase
VagYM19_44440	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VagYM19_44450	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VagYM19_44470	COG0454	-acetyltransferase
VagYM19_44490	COG2814	Major facilitator Superfamily
VagYM19_44570	COG0628	permease
VagYM19_44580	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VagYM19_44590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VagYM19_44610	COG4628	conserved protein (DUF2132)
VagYM19_44620	COG0583	DNA-binding transcription factor activity
VagYM19_44670	COG1686	Belongs to the peptidase S11 family
VagYM19_44720	COG0415	Belongs to the DNA photolyase family
VagYM19_44730	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
VagYM19_44740	COG3397	chitin binding
VagYM19_44750	COG4667	esterase of the alpha-beta hydrolase superfamily
VagYM19_44760	COG2095	MarC family integral membrane protein
VagYM19_44790	COG1596	polysaccharide export
VagYM19_44830	COG1301	dicarboxylic acid transport
VagYM19_44840	COG3339	Conserved Protein
VagYM19_44860	COG0700	Nucleoside recognition
VagYM19_44870	COG3366	ferrous iron transmembrane transporter activity
VagYM19_44890	COG0366	Alpha amylase catalytic
VagYM19_44900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VagYM19_44910	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VagYM19_44920	COG1640	4-alpha-glucanotransferase
VagYM19_44930	COG0058	SHG alpha-glucan phosphorylase activity
VagYM19_44940	COG2909	trisaccharide binding
VagYM19_44970	COG1999	signal sequence binding
VagYM19_44980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VagYM19_44980	COG1263	PTS System
VagYM19_44990	COG1162	GTPase activity
VagYM19_45000	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
VagYM19_45010	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
VagYM19_45030	COG0531	amino acid
VagYM19_45040	COG1982	Orn Lys Arg decarboxylase major
VagYM19_45080	COG2356	endonuclease I
VagYM19_45120	COG4580	involved in the transport of maltose and maltodextrins
VagYM19_45200	COG0739	heme binding
VagYM19_45210	COG0612	Peptidase, M16
VagYM19_45220	COG0840	transmembrane signaling receptor activity
VagYM19_45230	COG1120	ATPase activity
VagYM19_45240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VagYM19_45250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VagYM19_45260	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
VagYM19_45270	COG4772	TonB-dependent receptor
VagYM19_45320	COG4264	IucA IucC family
VagYM19_45330	COG0019	diaminopimelate decarboxylase activity
VagYM19_45340	COG1653	transport
VagYM19_45360	COG0745	RESPONSE REGULATOR receiver
VagYM19_45430	COG0463	Glycosyl transferase, family 2
VagYM19_45460	COG1136	(ABC) transporter
VagYM19_45500	COG1764	response to oxidative stress
VagYM19_45510	COG1846	Transcriptional regulator
VagYM19_45530	COG3634	alkyl hydroperoxide reductase activity
VagYM19_45580	COG1595	DNA-templated transcription, initiation
VagYM19_45620	COG2258	MOSC domain
VagYM19_45670	COG2207	Transcriptional regulator
VagYM19_45690	COG1132	(ABC) transporter
VagYM19_45780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VagYM19_45830	COG0259	pyridoxamine-phosphate oxidase activity
VagYM19_45930	COG4166	transmembrane transport
VagYM19_45960	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VagYM19_45970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VagYM19_45970	COG1263	PTS System
VagYM19_45980	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VagYM19_46020	COG1444	tRNA N-acetyltransferase activity