locus-tag	class	description
K6752_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K6752_00010	COG0592	DNA-directed DNA polymerase activity
K6752_00020	COG0187	DNA topoisomerase II activity
K6752_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
K6752_00035	COG3977	Valine--pyruvate aminotransferase
K6752_00040	COG0366	Alpha amylase catalytic
K6752_00055	COG2119	membrane
K6752_00065	COG0425	Belongs to the sulfur carrier protein TusA family
K6752_00080	COG0604	alcohol dehydrogenase
K6752_00085	COG0183	Belongs to the thiolase family
K6752_00095	COG1739	Uncharacterized protein family UPF0029
K6752_00100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6752_00150	COG2132	Multicopper oxidase
K6752_00170	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K6752_00175	COG2104	thiamine diphosphate biosynthetic process
K6752_00190	COG0006	proline dipeptidase activity
K6752_00190	COG0006	proline dipeptidase activity
K6752_00220	COG3220	belongs to the UPF0276 family
K6752_00230	COG0210	DNA helicase
K6752_00235	COG0405	Gamma-glutamyltransferase
K6752_00240	COG1280	lysine exporter protein (LysE YggA)
K6752_00250	COG2962	Rard protein
K6752_00255	COG0514	ATP-dependent DNA helicase (RecQ)
K6752_00265	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K6752_00275	COG0248	Ppx GppA phosphatase
K6752_00280	COG0513	Belongs to the DEAD box helicase family
K6752_00285	COG3118	belongs to the thioredoxin family
K6752_00300	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K6752_00305	COG0633	Ferredoxin
K6752_00345	COG3071	HemY protein
K6752_00350	COG2959	enzyme of heme biosynthesis
K6752_00355	COG1587	Uroporphyrinogen-III synthase
K6752_00360	COG0181	hydroxymethylbilane synthase activity
K6752_00365	COG3072	Adenylate cyclase
K6752_00370	COG1965	Belongs to the frataxin family
K6752_00380	COG0019	diaminopimelate decarboxylase activity
K6752_00395	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K6752_00400	COG1011	Hydrolase
K6752_00405	COG3287	FIST C domain
K6752_00405	COG2200	EAL domain
K6752_00405	COG2199	diguanylate cyclase activity
K6752_00410	COG3148	PFAM DTW domain containing protein
K6752_00425	COG0561	phosphatase activity
K6752_00430	COG2267	carboxylic ester hydrolase activity
K6752_00435	COG1280	lysine exporter protein (LysE YggA)
K6752_00440	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K6752_00445	COG0640	Transcriptional regulator
K6752_00450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K6752_00490	COG2095	MarC family integral membrane protein
K6752_00500	COG0742	ribosomal rna small subunit methyltransferase
K6752_00505	COG0552	protein localization to endoplasmic reticulum
K6752_00510	COG2884	Cell division ATP-binding protein ftsE
K6752_00515	COG2177	Part of the ABC transporter FtsEX involved in
K6752_00525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6752_00530	COG0705	Rhomboid family
K6752_00535	COG1580	Controls the rotational direction of flagella during chemotaxis
K6752_00540	COG3161	chorismate lyase activity
K6752_00545	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K6752_00550	COG2937	Belongs to the GPAT DAPAT family
K6752_00555	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K6752_00560	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K6752_00565	COG0534	Mate efflux family protein
K6752_00570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6752_00590	COG4206	TonB-dependent receptor
K6752_00655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6752_00665	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K6752_00670	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K6752_00670	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K6752_00705	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K6752_00710	COG0250	Participates in transcription elongation, termination and antitermination
K6752_00725	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K6752_00730	COG0222	ribosome binding
K6752_00735	COG0085	RNA polymerase activity
K6752_00740	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K6752_00745	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
K6752_00750	COG2816	NAD+ diphosphatase activity
K6752_00755	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K6752_00760	COG1573	uracil-dna glycosylase
K6752_00770	COG3068	Protein conserved in bacteria
K6752_00775	COG1253	flavin adenine dinucleotide binding
K6752_00790	COG0151	Belongs to the GarS family
K6752_00800	COG0789	Transcriptional regulator
K6752_00805	COG3710	Transcriptional regulator
K6752_00810	COG0531	amino acid
K6752_00815	COG1982	Orn Lys Arg decarboxylase major
K6752_00875	COG0488	(ABC) transporter
K6752_00885	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K6752_00890	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6752_00895	COG2264	protein methyltransferase activity
K6752_00900	COG0439	Biotin carboxylase
K6752_00905	COG0511	ligase activity, forming carbon-carbon bonds
K6752_00910	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K6752_00915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6752_00930	COG2814	Major facilitator Superfamily
K6752_00955	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6752_00965	COG3263	regulation of cellular component size
K6752_00975	COG4232	protein-disulfide reductase activity
K6752_00980	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K6752_00985	COG1027	Aspartate ammonia-lyase
K6752_00990	COG3030	protein affecting phage T7 exclusion by the F plasmid
K6752_00995	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K6752_01005	COG2205	protein histidine kinase activity
K6752_01010	COG0745	RESPONSE REGULATOR receiver
K6752_01015	COG3678	ATP-independent chaperone mediated protein folding
K6752_01025	COG0205	6-phosphofructokinase activity
K6752_01030	COG0534	Mate efflux family protein
K6752_01040	COG0459	protein refolding
K6752_01050	COG1285	pathogenesis
K6752_01055	COG1509	lysine 2,3-aminomutase activity
K6752_01070	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K6752_01075	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K6752_01080	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K6752_01085	COG1053	succinate dehydrogenase
K6752_01090	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K6752_01110	COG4942	peptidase
K6752_01115	COG1045	serine acetyltransferase
K6752_01120	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K6752_01125	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K6752_01130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6752_01135	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K6752_01145	COG3273	potassium ion transport
K6752_01145	COG0471	metal ion transport
K6752_01150	COG0688	phosphatidylethanolamine metabolic process
K6752_01155	COG1162	GTPase activity
K6752_01160	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K6752_01225	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K6752_01230	COG0802	atpase or kinase
K6752_01240	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K6752_01245	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K6752_01255	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K6752_01260	COG0330	HflC and HflK could
K6752_01265	COG0330	HflC and HflK could
K6752_01270	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
K6752_01275	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K6752_01280	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
K6752_01285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K6752_01285	COG1017	nitric oxide dioxygenase activity
K6752_01290	COG1959	2 iron, 2 sulfur cluster binding
K6752_01295	COG0557	exoribonuclease II activity
K6752_01300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6752_01305	COG0546	phosphoglycolate phosphatase activity
K6752_01310	COG0180	Tryptophanyl-tRNA synthetase
K6752_01325	COG0583	DNA-binding transcription factor activity
K6752_01330	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K6752_01335	COG1473	amidohydrolase
K6752_01345	COG0697	spore germination
K6752_01355	COG0512	Glutamine amidotransferase of anthranilate synthase
K6752_01360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K6752_01380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6752_01385	COG3954	Phosphoribulokinase
K6752_01395	COG0429	hydrolase of the alpha beta-hydrolase fold
K6752_01405	COG0488	(ABC) transporter
K6752_01410	COG2249	NAD(P)H dehydrogenase (quinone) activity
K6752_01425	COG1047	Peptidyl-prolyl cis-trans
K6752_01430	COG1446	asparaginase
K6752_01445	COG0545	Peptidyl-prolyl cis-trans isomerase
K6752_01450	COG2964	Protein conserved in bacteria
K6752_01455	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
K6752_01460	COG2923	Belongs to the DsrF TusC family
K6752_01480	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K6752_01485	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K6752_01500	COG0281	malic enzyme
K6752_01505	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
K6752_01510	COG0626	cystathionine gamma-synthase activity
K6752_01515	COG0527	aspartate kinase activity
K6752_01515	COG0460	homoserine dehydrogenase
K6752_01520	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K6752_01530	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K6752_01540	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K6752_01550	COG0137	argininosuccinate synthase activity
K6752_01555	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K6752_01555	COG0165	Argininosuccinate lyase
K6752_01570	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K6752_01570	COG0678	peroxiredoxin activity
K6752_01580	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K6752_01610	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K6752_01615	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K6752_01625	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K6752_01630	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K6752_01635	COG0360	Binds together with S18 to 16S ribosomal RNA
K6752_01640	COG2965	DNA replication, synthesis of RNA primer
K6752_01665	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K6752_01670	COG0432	Pfam Uncharacterised protein family UPF0047
K6752_01675	COG0166	Belongs to the GPI family
K6752_01685	COG0735	belongs to the Fur family
K6752_01690	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6752_01710	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K6752_01715	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6752_01720	COG0175	sulfate reduction
K6752_01780	COG0646	methionine synthase
K6752_01780	COG1410	methionine synthase
K6752_01785	COG0527	aspartate kinase activity
K6752_01790	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K6752_01800	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K6752_01815	COG0629	single-stranded DNA binding
K6752_01820	COG2200	EAL domain
K6752_01820	COG2199	diguanylate cyclase activity
K6752_01840	COG1450	Type ii and iii secretion system protein
K6752_01845	COG3267	Type II secretory pathway component ExeA
K6752_01845	COG3409	Peptidoglycan-binding domain 1 protein
K6752_01855	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K6752_01860	COG1459	type II secretion system
K6752_01870	COG2165	general secretion pathway protein
K6752_01905	COG1077	Cell shape determining protein MreB Mrl
K6752_01910	COG1792	Involved in formation and maintenance of cell shape
K6752_01915	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K6752_01920	COG0424	maF-like protein
K6752_01930	COG3164	Protein of unknown function
K6752_01935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6752_01940	COG0312	modulator of DNA gyrase
K6752_01945	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K6752_01950	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K6752_01960	COG0564	pseudouridine synthase activity
K6752_01965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6752_01970	COG3028	Belongs to the UPF0307 family
K6752_01975	COG0312	modulator of DNA gyrase
K6752_01980	COG2239	Acts as a magnesium transporter
K6752_01985	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6752_01990	COG1660	Displays ATPase and GTPase activities
K6752_01995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6752_02000	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K6752_02010	COG1137	ATPase activity
K6752_02015	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K6752_02025	COG0517	IMP dehydrogenase activity
K6752_02025	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K6752_02035	COG1127	ABC transporter
K6752_02040	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K6752_02045	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K6752_02050	COG2854	intermembrane phospholipid transfer
K6752_02060	COG5007	Belongs to the BolA IbaG family
K6752_02065	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K6752_02070	COG0204	Acyl-transferase
K6752_02075	COG0251	oxidation-reduction process
K6752_02080	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K6752_02085	COG0540	Belongs to the ATCase OTCase family
K6752_02115	COG0456	acetyltransferase
K6752_02125	COG0525	valine-tRNA ligase activity
K6752_02130	COG2927	DNA polymerase III (CHI subunit)
K6752_02135	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K6752_02140	COG0795	lipopolysaccharide-transporting ATPase activity
K6752_02145	COG0795	lipopolysaccharide-transporting ATPase activity
K6752_02160	COG1028	Short-chain dehydrogenase reductase Sdr
K6752_02260	COG0726	polysaccharide deacetylase
K6752_02265	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K6752_02270	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K6752_02275	COG1447	Phosphotransferase system cellobiose-specific component IIA
K6752_02280	COG1486	melibiose metabolic process
K6752_02285	COG3394	polysaccharide catabolic process
K6752_02290	COG1609	Transcriptional regulator
K6752_02295	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K6752_02370	COG0840	transmembrane signaling receptor activity
K6752_02415	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
K6752_02425	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K6752_02435	COG2066	Belongs to the glutaminase family
K6752_02440	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K6752_02445	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K6752_02455	COG1872	DUF167
K6752_02460	COG0762	integral membrane protein
K6752_02465	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K6752_02470	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K6752_02485	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K6752_02490	COG1678	Uncharacterized ACR, COG1678
K6752_02495	COG0189	ligase activity
K6752_02500	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K6752_02505	COG2356	endonuclease I
K6752_02520	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K6752_02525	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K6752_02530	COG0583	DNA-binding transcription factor activity
K6752_02535	COG4771	TonB-dependent receptor
K6752_02550	COG0191	fructose-bisphosphate aldolase activity
K6752_02555	COG0668	transmembrane transport
K6752_02570	COG0583	DNA-binding transcription factor activity
K6752_02580	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6752_02585	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K6752_02590	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K6752_02600	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K6752_02605	COG3079	Belongs to the UPF0149 family
K6752_02610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6752_02615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6752_02635	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K6752_02645	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K6752_02650	COG1595	DNA-templated transcription, initiation
K6752_02665	COG3086	response to oxidative stress
K6752_02670	COG0481	GTPase activity
K6752_02675	COG0681	Belongs to the peptidase S26 family
K6752_02685	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K6752_02690	COG1381	Involved in DNA repair and RecF pathway recombination
K6752_02695	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K6752_02700	COG0736	holo-[acyl-carrier-protein] synthase activity
K6752_02710	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K6752_02715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K6752_02720	COG3956	TIGRFAM MazG family protein
K6752_02725	COG0504	CTP synthase activity
K6752_02730	COG0148	phosphopyruvate hydratase activity
K6752_02735	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K6752_02740	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K6752_02745	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K6752_02755	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K6752_02760	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K6752_02770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K6752_02775	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K6752_02780	COG1546	Belongs to the CinA family
K6752_02785	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K6752_02790	COG2137	regulation of response to DNA damage stimulus
K6752_02795	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K6752_02800	COG0527	aspartate kinase activity
K6752_02860	COG3630	sodium ion export across plasma membrane
K6752_02865	COG5016	pyruvate
K6752_02865	COG0511	ligase activity, forming carbon-carbon bonds
K6752_02870	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K6752_02880	COG1238	metal cluster binding
K6752_02885	COG0612	Peptidase, M16
K6752_02900	COG1854	S-ribosylhomocysteine lyase activity
K6752_02905	COG4536	flavin adenine dinucleotide binding
K6752_02910	COG4137	Cytochrome C assembly protein
K6752_02915	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K6752_02920	COG0228	four-way junction DNA binding
K6752_02925	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K6752_02940	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K6752_02945	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
K6752_02950	COG0237	dephospho-CoA kinase activity
K6752_02960	COG1459	type II secretion system
K6752_02965	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K6752_02970	COG4969	Belongs to the N-Me-Phe pilin family
K6752_02975	COG0157	Belongs to the NadC ModD family
K6752_02985	COG2186	Transcriptional regulator
K6752_02990	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K6752_02995	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6752_03000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6752_03015	COG0288	reversible hydration of carbon dioxide
K6752_03020	COG0659	secondary active sulfate transmembrane transporter activity
K6752_03025	COG1131	(ABC) transporter
K6752_03030	COG0842	Transport permease protein
K6752_03035	COG1560	Kdo2-lipid A biosynthetic process
K6752_03040	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K6752_03045	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K6752_03050	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K6752_03060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K6752_03070	COG1489	DNA binding
K6752_03075	COG1643	Atp-dependent helicase
K6752_03080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6752_03085	COG1752	Esterase of the alpha-beta hydrolase superfamily
K6752_03090	COG1049	propionate catabolic process, 2-methylcitrate cycle
K6752_03095	COG3112	Uncharacterised protein family (UPF0231)
K6752_03105	COG0004	ammonium transporteR
K6752_03110	COG1840	ABC-type Fe3 transport system, periplasmic component
K6752_03120	COG3842	ATPase activity
K6752_03125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6752_03140	COG2971	BadF BadG BcrA BcrD
K6752_03150	COG4608	Belongs to the ABC transporter superfamily
K6752_03155	COG0444	Belongs to the ABC transporter superfamily
K6752_03160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6752_03170	COG0747	negative chemotaxis
K6752_03175	COG0784	Response regulator, receiver
K6752_03175	COG2205	protein histidine kinase activity
K6752_03185	COG0628	permease
K6752_03210	COG0739	heme binding
K6752_03215	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K6752_03225	COG2027	D-alanyl-D-alanine carboxypeptidase
K6752_03230	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6752_03235	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6752_03240	COG1534	Rna-binding protein
K6752_03245	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K6752_03250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K6752_03255	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K6752_03260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6752_03265	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K6752_03280	COG0779	Required for maturation of 30S ribosomal subunits
K6752_03285	COG0195	Participates in both transcription termination and antitermination
K6752_03290	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K6752_03295	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K6752_03300	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K6752_03305	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K6752_03310	COG1185	polyribonucleotide nucleotidyltransferase activity
K6752_03325	COG0534	Mate efflux family protein
K6752_03330	COG0826	peptidase U32
K6752_03335	COG0826	peptidase U32
K6752_03345	COG3154	lipid carrier protein
K6752_03350	COG3153	acetyltransferase
K6752_03380	COG0084	hydrolase, TatD family'
K6752_03385	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6752_03390	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K6752_03395	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K6752_03400	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K6752_03405	COG0813	purine-nucleoside phosphorylase activity
K6752_03415	COG0560	Phosphoserine phosphatase
K6752_03425	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K6752_03430	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K6752_03435	COG0583	DNA-binding transcription factor activity
K6752_03445	COG1022	Amp-dependent synthetase and ligase
K6752_03485	COG0583	DNA-binding transcription factor activity
K6752_03490	COG1609	Transcriptional regulator
K6752_03510	COG0598	Magnesium transport protein CorA
K6752_03515	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K6752_03520	COG1349	DNA-binding transcription factor activity
K6752_03525	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K6752_03530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K6752_03535	COG2271	Major facilitator Superfamily
K6752_03540	COG0584	glycerophosphoryl diester phosphodiesterase
K6752_03545	COG2171	N-acyltransferase activity
K6752_03560	COG3141	response to X-ray
K6752_03580	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K6752_03585	COG1074	ATP-dependent DNA helicase activity
K6752_03590	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K6752_03600	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K6752_03600	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K6752_03610	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
K6752_03615	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K6752_03620	COG2166	iron-sulfur cluster assembly
K6752_03625	COG3706	GGDEF domain
K6752_03630	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K6752_03635	COG0693	protein deglycase activity
K6752_03640	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K6752_03660	COG1595	DNA-templated transcription, initiation
K6752_03680	COG3056	Lipoprotein
K6752_03685	COG2813	Specifically methylates the guanine in position
K6752_03690	COG0271	Belongs to the BolA IbaG family
K6752_03695	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6752_03700	COG1805	sodium ion transport
K6752_03705	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6752_03710	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6752_03715	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6752_03720	COG2871	sodium ion transport
K6752_03725	COG1477	protein flavinylation
K6752_03745	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K6752_03750	COG0514	ATP-dependent DNA helicase (RecQ)
K6752_03755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6752_03770	COG0733	neurotransmitter:sodium symporter activity
K6752_03790	COG0442	prolyl-tRNA aminoacylation
K6752_03795	COG1720	tRNA m6t6A37 methyltransferase activity
K6752_03800	COG0254	rRNA binding
K6752_03810	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K6752_03835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6752_03840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6752_03875	COG0564	pseudouridine synthase activity
K6752_03885	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K6752_03890	COG0024	Methionine aminopeptidase
K6752_03895	COG0052	Belongs to the universal ribosomal protein uS2 family
K6752_03900	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K6752_03905	COG0528	UMP kinase activity
K6752_03910	COG0233	cytoplasmic translational termination
K6752_03915	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K6752_03920	COG0575	Belongs to the CDS family
K6752_03925	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K6752_03930	COG0750	zinc metalloprotease
K6752_03940	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
K6752_03945	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6752_03955	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6752_03960	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6752_03970	COG0587	DNA-directed DNA polymerase activity
K6752_03975	COG0825	malonyl-CoA metabolic process
K6752_03990	COG0347	Belongs to the P(II) protein family
K6752_03995	COG3021	interspecies interaction between organisms
K6752_04005	COG0741	lytic transglycosylase activity
K6752_04005	COG1388	LysM domain
K6752_04010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6752_04015	COG2226	methyltransferase
K6752_04020	COG0328	RNA-DNA hybrid ribonuclease activity
K6752_04055	COG1960	acyl-CoA dehydrogenase activity
K6752_04060	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K6752_04065	COG0121	glutamine amidotransferase
K6752_04070	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K6752_04075	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K6752_04080	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K6752_04090	COG2233	PERMEase
K6752_04110	COG1393	Belongs to the ArsC family
K6752_04115	COG4783	chaperone-mediated protein folding
K6752_04130	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K6752_04140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6752_04145	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
K6752_04160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6752_04165	COG1393	Belongs to the ArsC family
K6752_04190	COG2837	iron assimilation
K6752_04195	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6752_04200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6752_04205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6752_04210	COG1334	flagellar protein FlaG
K6752_04215	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K6752_04225	COG1516	flagellar protein fliS
K6752_04245	COG1677	Flagellar hook-basal body complex protein FliE
K6752_04255	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K6752_04310	COG1987	bacterial-type flagellum assembly
K6752_04315	COG1684	flagellar biosynthetic protein fliR
K6752_04350	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
K6752_04355	COG0643	Histidine kinase
K6752_04355	COG0784	Response regulator, receiver
K6752_04355	COG2198	Histidine kinase
K6752_04360	COG2201	protein-glutamate methylesterase activity
K6752_04365	COG1192	Involved in chromosome partitioning
K6752_04375	COG0835	chemotaxis
K6752_04385	COG4133	protoheme IX ABC transporter activity
K6752_04390	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6752_04395	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6752_04400	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6752_04405	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K6752_04410	COG1138	Cytochrome C-type biogenesis protein
K6752_04415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6752_04425	COG3088	subunit of a heme lyase
K6752_04425	COG4235	cytochrome complex assembly
K6752_04435	COG2067	long-chain fatty acid transport protein
K6752_04455	COG0183	Belongs to the thiolase family
K6752_04460	COG1024	Enoyl-CoA hydratase
K6752_04460	COG1250	3-hydroxyacyl-CoA dehydrogenase
K6752_04475	COG2062	phosphohistidine phosphatase, SixA
K6752_04480	COG2840	Smr protein MutS2
K6752_04485	COG2890	protein-(glutamine-N5) methyltransferase activity
K6752_04490	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K6752_04495	COG2860	membrane
K6752_04500	COG3101	peptidyl-lysine hydroxylation
K6752_04510	COG0431	NADPH-dependent FMN reductase
K6752_04515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6752_04515	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K6752_04520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K6752_04525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6752_04530	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K6752_04540	COG0101	tRNA pseudouridine synthase activity
K6752_04545	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K6752_04550	COG0285	dihydrofolate synthase activity
K6752_04555	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
K6752_04560	COG1286	toxin biosynthetic process
K6752_04565	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K6752_04570	COG0583	DNA-binding transcription factor activity
K6752_04575	COG0745	RESPONSE REGULATOR receiver
K6752_04580	COG2832	Protein of unknown function (DUF454)
K6752_04585	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K6752_04600	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K6752_04605	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K6752_04615	COG2261	transglycosylase associated protein
K6752_04620	COG2983	Belongs to the UPF0260 family
K6752_04625	COG0668	transmembrane transport
K6752_04630	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
K6752_04635	COG0346	lactoylglutathione lyase activity
K6752_04645	COG1785	Belongs to the alkaline phosphatase family
K6752_04660	COG2226	methyltransferase
K6752_04675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K6752_04680	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6752_04690	COG3139	Protein of unknown function (DUF1315)
K6752_04695	COG0252	asparaginase activity
K6752_04700	COG0616	signal peptide processing
K6752_04705	COG0446	pyridine nucleotide-disulphide oxidoreductase
K6752_04705	COG1902	pentaerythritol trinitrate reductase activity
K6752_04715	COG0778	Nitroreductase
K6752_04720	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K6752_04735	COG0123	including yeast histone deacetylase and acetoin utilization protein
K6752_04750	COG3082	Protein of unknown function (DUF1414)
K6752_04755	COG3081	Nucleoid-associated protein
K6752_04770	COG1757	Na H antiporter
K6752_04775	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K6752_04780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6752_04785	COG2095	MarC family integral membrane protein
K6752_04790	COG1454	alcohol dehydrogenase
K6752_04790	COG1012	belongs to the aldehyde dehydrogenase family
K6752_04810	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K6752_04820	COG2056	Na+-H+ antiporter family
K6752_04825	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K6752_04830	COG2885	chlorophyll binding
K6752_04840	COG0346	lactoylglutathione lyase activity
K6752_04845	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K6752_04850	COG4660	Part of a membrane complex involved in electron transport
K6752_04855	COG4659	FMN binding
K6752_04860	COG4658	electron transport chain
K6752_04865	COG4656	Part of a membrane complex involved in electron transport
K6752_04870	COG2878	Part of a membrane complex involved in electron transport
K6752_04875	COG4657	Part of a membrane complex involved in electron transport
K6752_04880	COG1882	Formate acetyltransferase
K6752_04890	COG0556	nucleotide-excision repair
K6752_04895	COG2204	response regulator
K6752_04900	COG2198	Histidine kinase
K6752_04905	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K6752_04910	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K6752_04915	COG0521	Mo-molybdopterin cofactor biosynthetic process
K6752_04920	COG0315	cyclic pyranopterin monophosphate synthase activity
K6752_04925	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K6752_04930	COG0314	molybdopterin synthase activity
K6752_04940	COG0601	transmembrane transport
K6752_04945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6752_04950	COG0444	Belongs to the ABC transporter superfamily
K6752_04960	COG0435	Glutathione S-transferase
K6752_04970	COG0280	phosphate acetyltransferase
K6752_04970	COG0857	belongs to the CobB CobQ family
K6752_04975	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K6752_04980	COG3092	negative regulation of chromosome organization
K6752_04990	COG4120	Belongs to the binding-protein-dependent transport system permease family
K6752_04995	COG1122	ATPase activity
K6752_05000	COG0366	Alpha amylase catalytic
K6752_05005	COG3706	GGDEF domain
K6752_05010	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6752_05015	COG0653	protein targeting
K6752_05020	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K6752_05025	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K6752_05030	COG2186	Transcriptional regulator
K6752_05040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6752_05040	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6752_05050	COG0572	uridine kinase
K6752_05060	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
K6752_05065	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K6752_05070	COG0659	secondary active sulfate transmembrane transporter activity
K6752_05075	COG1530	ribonuclease E activity
K6752_05080	COG0564	pseudouridine synthase activity
K6752_05085	COG0424	maF-like protein
K6752_05090	COG1399	metal-binding, possibly nucleic acid-binding protein
K6752_05100	COG0416	fatty acid biosynthetic process
K6752_05105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6752_05135	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K6752_05140	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K6752_05145	COG0470	DNA polymerase III
K6752_05150	COG0084	hydrolase, TatD family'
K6752_05155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6752_05155	COG1263	PTS System
K6752_05170	COG0733	neurotransmitter:sodium symporter activity
K6752_05185	COG4667	esterase of the alpha-beta hydrolase superfamily
K6752_05190	COG0469	pyruvate kinase activity
K6752_05195	COG1940	carbohydrate kinase activity
K6752_05200	COG0784	Response regulator, receiver
K6752_05200	COG0835	chemotaxis
K6752_05205	COG0587	DNA-directed DNA polymerase activity
K6752_05220	COG1028	Short-chain dehydrogenase reductase Sdr
K6752_05225	COG0616	signal peptide processing
K6752_05230	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K6752_05235	COG0539	negative regulation of cytoplasmic translation
K6752_05245	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
K6752_05250	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K6752_05260	COG4166	transmembrane transport
K6752_05280	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K6752_05280	COG3008	intermembrane lipid transfer
K6752_05285	COG2995	paraquat-inducible protein a
K6752_05290	COG3258	Cytochrome c
K6752_05295	COG2863	cytochrome
K6752_05330	COG4232	protein-disulfide reductase activity
K6752_05335	COG3118	belongs to the thioredoxin family
K6752_05360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6752_05370	COG1136	(ABC) transporter
K6752_05370	COG0577	efflux transmembrane transporter activity
K6752_05380	COG0577	efflux transmembrane transporter activity
K6752_05380	COG1136	(ABC) transporter
K6752_05430	COG3850	Histidine kinase
K6752_05430	COG5002	protein histidine kinase activity
K6752_05435	COG0745	RESPONSE REGULATOR receiver
K6752_05440	COG0463	Glycosyl transferase, family 2
K6752_05445	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K6752_05465	COG1032	radical SAM domain protein
K6752_05470	COG5001	Diguanylate cyclase
K6752_05485	COG0583	DNA-binding transcription factor activity
K6752_05490	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K6752_05500	COG2350	Protein conserved in bacteria
K6752_05510	COG2917	probably involved in intracellular septation
K6752_05530	COG1301	dicarboxylic acid transport
K6752_05535	COG0318	PFAM AMP-dependent synthetase and ligase
K6752_05540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6752_05545	COG0159	tryptophan synthase activity
K6752_05555	COG0134	indole-3-glycerol-phosphate synthase activity
K6752_05555	COG0135	phosphoribosylanthranilate isomerase activity
K6752_05565	COG0512	Glutamine amidotransferase of anthranilate synthase
K6752_05570	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K6752_05580	COG0613	PHP domain protein
K6752_05585	COG0009	L-threonylcarbamoyladenylate synthase
K6752_05595	COG1187	pseudouridine synthase activity
K6752_05615	COG0417	DNA replication proofreading
K6752_05620	COG2197	response regulator
K6752_05625	COG0322	excinuclease ABC activity
K6752_05665	COG0019	diaminopimelate decarboxylase activity
K6752_05695	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K6752_05700	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K6752_05720	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
K6752_05730	COG0437	4 iron, 4 sulfur cluster binding
K6752_05735	COG3301	Polysulphide reductase, NrfD
K6752_05740	COG1138	Cytochrome C-type biogenesis protein
K6752_05745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6752_05750	COG3088	subunit of a heme lyase
K6752_05750	COG4235	cytochrome complex assembly
K6752_05760	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6752_05785	COG2989	Protein conserved in bacteria
K6752_05790	COG3108	Peptidase M15
K6752_05795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6752_05810	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K6752_05840	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6752_05845	COG0840	transmembrane signaling receptor activity
K6752_05865	COG1448	Aminotransferase
K6752_05880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6752_05890	COG0017	Asparaginyl-tRNA synthetase
K6752_05895	COG0840	transmembrane signaling receptor activity
K6752_05900	COG0720	synthase
K6752_05910	COG2200	EAL domain
K6752_05915	COG1760	l-serine dehydratase
K6752_05920	COG0814	amino acid
K6752_05925	COG0494	nUDIX hydrolase
K6752_05935	COG0784	Response regulator, receiver
K6752_05935	COG2205	protein histidine kinase activity
K6752_05955	COG3106	COG3106 Predicted ATPase
K6752_05960	COG3768	UPF0283 membrane protein
K6752_05970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6752_05985	COG1278	Cold shock
K6752_06005	COG1278	Cold shock
K6752_06020	COG0113	porphobilinogen synthase activity
K6752_06030	COG0582	viral genome integration into host DNA
K6752_06050	COG5532	Uncharacterized conserved protein (DUF2303)
K6752_06095	COG4626	Terminase
K6752_06095	COG1802	Transcriptional regulator
K6752_06105	COG3645	SOS response
K6752_06105	COG3646	Phage regulatory protein
K6752_06115	COG1403	HNH endonuclease
K6752_06155	COG3772	lysozyme
K6752_06185	COG1030	water channel activity
K6752_06330	COG2026	Addiction module toxin, RelE StbE family
K6752_06440	COG1714	RDD family
K6752_06595	COG0346	lactoylglutathione lyase activity
K6752_06805	COG2026	Addiction module toxin, RelE StbE family
K6752_06935	COG0110	maltose O-acetyltransferase activity
K6752_06940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6752_06945	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K6752_06965	COG5507	3-demethylubiquinone-9 3-methyltransferase
K6752_06970	COG1280	lysine exporter protein (LysE YggA)
K6752_06975	COG1280	lysine exporter protein (LysE YggA)
K6752_06985	COG0729	surface antigen
K6752_06990	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6752_06995	COG2272	Belongs to the type-B carboxylesterase lipase family
K6752_07020	COG2985	domain, Protein
K6752_07030	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K6752_07060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6752_07075	COG3290	protein histidine kinase activity
K6752_07080	COG4565	transcriptional regulatory protein
K6752_07090	COG2207	Transcriptional regulator
K6752_07095	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K6752_07100	COG0363	glucosamine-6-phosphate deaminase activity
K6752_07105	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K6752_07125	COG3284	Transcriptional regulator
K6752_07130	COG1012	belongs to the aldehyde dehydrogenase family
K6752_07200	COG4669	(LipO)protein
K6752_07220	COG3177	Filamentation induced by cAMP protein fic
K6752_07250	COG2207	Transcriptional regulator
K6752_07255	COG4792	protein secretion
K6752_07260	COG4791	protein targeting
K6752_07265	COG4794	Type iii secretion
K6752_07270	COG4790	Type iii secretion
K6752_07340	COG0457	Tetratricopeptide repeat
K6752_07355	COG2358	TRAP transporter, solute receptor (TAXI family
K6752_07360	COG0730	response to heat
K6752_07395	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K6752_07400	COG0372	Belongs to the citrate synthase family
K6752_07410	COG2828	Protein conserved in bacteria
K6752_07435	COG0561	phosphatase activity
K6752_07440	COG0602	queuosine metabolic process
K6752_07445	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K6752_07460	COG0583	DNA-binding transcription factor activity
K6752_07465	COG0583	DNA-binding transcription factor activity
K6752_07480	COG0583	DNA-binding transcription factor activity
K6752_07495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6752_07500	COG0765	amino acid transport
K6752_07505	COG1126	abc transporter atp-binding protein
K6752_07510	COG1410	methionine synthase
K6752_07510	COG0646	methionine synthase
K6752_07525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6752_07530	COG1335	isochorismatase
K6752_07550	COG2814	Major facilitator Superfamily
K6752_07555	COG0583	DNA-binding transcription factor activity
K6752_07565	COG0583	DNA-binding transcription factor activity
K6752_07570	COG0656	L-ascorbic acid biosynthetic process
K6752_07580	COG1414	Transcriptional regulator
K6752_07585	COG2199	diguanylate cyclase activity
K6752_07585	COG2203	Gaf domain
K6752_07615	COG2885	chlorophyll binding
K6752_07640	COG1254	Belongs to the acylphosphatase family
K6752_07645	COG2920	part of a sulfur-relay system
K6752_07655	COG0670	Belongs to the BI1 family
K6752_07660	COG1126	abc transporter atp-binding protein
K6752_07665	COG0765	amino acid transport
K6752_07670	COG4597	amino acid ABC transporter
K6752_07675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6752_07685	COG1666	GTP binding
K6752_07690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K6752_07715	COG3008	intermembrane lipid transfer
K6752_07720	COG2995	paraquat-inducible protein a
K6752_07725	COG1132	(ABC) transporter
K6752_07730	COG1956	GAF domain-containing protein
K6752_07735	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
K6752_07750	COG0308	aminopeptidase N
K6752_07760	COG2902	Dehydrogenase
K6752_07765	COG0167	dihydroorotate dehydrogenase activity
K6752_07775	COG0116	Belongs to the methyltransferase superfamily
K6752_07775	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K6752_07785	COG0488	(ABC) transporter
K6752_07800	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K6752_07805	COG1067	ATP-dependent peptidase activity
K6752_07810	COG3120	sequence-specific DNA binding
K6752_07820	COG2205	protein histidine kinase activity
K6752_07820	COG0784	Response regulator, receiver
K6752_07835	COG3278	Belongs to the heme-copper respiratory oxidase family
K6752_07850	COG2010	Cytochrome c
K6752_07860	COG2217	Heavy metal translocating P-type atpase
K6752_07875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6752_07880	COG0589	response to stress
K6752_07905	COG3842	ATPase activity
K6752_07915	COG1177	transmembrane transport
K6752_07925	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K6752_07930	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K6752_07940	COG0004	ammonium transporteR
K6752_07965	COG0437	4 iron, 4 sulfur cluster binding
K6752_07970	COG0243	molybdopterin cofactor binding
K6752_07970	COG3383	formate dehydrogenase (NAD+) activity
K6752_08000	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K6752_08005	COG0488	(ABC) transporter
K6752_08010	COG4191	Histidine kinase
K6752_08015	COG2204	response regulator
K6752_08030	COG3842	ATPase activity
K6752_08035	COG0746	molybdenum cofactor guanylyltransferase activity
K6752_08040	COG0303	'Molybdopterin
K6752_08050	COG1940	carbohydrate kinase activity
K6752_08055	COG3148	PFAM DTW domain containing protein
K6752_08085	COG0791	NLP P60 protein
K6752_08095	COG3706	GGDEF domain
K6752_08105	COG3001	Fructosamine kinase
K6752_08115	COG0307	riboflavin synthase, alpha
K6752_08120	COG0534	Mate efflux family protein
K6752_08130	COG1793	dna ligase
K6752_08160	COG2204	response regulator
K6752_08165	COG0297	glycogen (starch) synthase activity
K6752_08170	COG0438	transferase activity, transferring glycosyl groups
K6752_08200	COG0438	transferase activity, transferring glycosyl groups
K6752_08205	COG1215	transferase activity, transferring glycosyl groups
K6752_08210	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6752_08220	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6752_08235	COG1643	Atp-dependent helicase
K6752_08240	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K6752_08285	COG0443	Heat shock 70 kDa protein
K6752_08290	COG0443	Heat shock 70 kDa protein
K6752_08305	COG0673	inositol 2-dehydrogenase activity
K6752_08315	COG0583	DNA-binding transcription factor activity
K6752_08330	COG1132	(ABC) transporter
K6752_08335	COG1132	(ABC) transporter
K6752_08355	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6752_08360	COG1120	ATPase activity
K6752_08375	COG0814	amino acid
K6752_08385	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K6752_08395	COG0861	Integral membrane protein TerC family
K6752_08405	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K6752_08410	COG1328	CTP reductase activity
K6752_08425	COG3300	MHYT domain
K6752_08425	COG5001	Diguanylate cyclase
K6752_08440	COG0471	metal ion transport
K6752_08465	COG4702	Belongs to the UPF0303 family
K6752_08470	COG0673	inositol 2-dehydrogenase activity
K6752_08475	COG1349	DNA-binding transcription factor activity
K6752_08490	COG1538	Outer membrane efflux protein
K6752_08515	COG3119	arylsulfatase activity
K6752_08530	COG0641	radical SAM
K6752_08545	COG3119	arylsulfatase activity
K6752_08550	COG0527	aspartate kinase activity
K6752_08555	COG0662	Cupin 2, conserved barrel domain protein
K6752_08560	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K6752_08565	COG0456	acetyltransferase
K6752_08570	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6752_08585	COG4175	Glycine betaine
K6752_08590	COG4176	ABC-type proline glycine betaine transport system permease component
K6752_08595	COG2113	Glycine betaine
K6752_08600	COG1368	sulfuric ester hydrolase activity
K6752_08625	COG1115	amino acid carrier protein
K6752_08635	COG1280	lysine exporter protein (LysE YggA)
K6752_08640	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K6752_08645	COG1560	Kdo2-lipid A biosynthetic process
K6752_08660	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K6752_08665	COG3063	Type IV pilus biogenesis stability protein PilW
K6752_08705	COG2315	Protein conserved in bacteria
K6752_08710	COG1846	Transcriptional regulator
K6752_08720	COG2200	EAL domain
K6752_08725	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K6752_08730	COG1012	belongs to the aldehyde dehydrogenase family
K6752_08735	COG2957	Belongs to the agmatine deiminase family
K6752_08745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6752_08750	COG1012	belongs to the aldehyde dehydrogenase family
K6752_08755	COG1396	sequence-specific DNA binding
K6752_08755	COG1917	Cupin 2, conserved barrel domain protein
K6752_08760	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K6752_08765	COG0174	glutamine synthetase
K6752_08770	COG1757	Na H antiporter
K6752_08785	COG1742	UPF0060 membrane protein
K6752_08810	COG3755	Protein conserved in bacteria
K6752_08860	COG0625	glutathione transferase activity
K6752_08870	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K6752_08880	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6752_08890	COG0601	transmembrane transport
K6752_08895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6752_08915	COG3291	Pkd domain containing protein
K6752_08925	COG1177	transmembrane transport
K6752_08930	COG1176	ABC-type spermidine putrescine transport system, permease component I
K6752_08935	COG3842	ATPase activity
K6752_08940	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6752_08945	COG2423	ornithine cyclodeaminase activity
K6752_08960	COG3938	Belongs to the proline racemase family
K6752_08990	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
K6752_08995	COG1451	nucleotide metabolic process
K6752_09005	COG0583	DNA-binding transcription factor activity
K6752_09025	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
K6752_09030	COG4139	cobalamin transport
K6752_09035	COG2988	succinylglutamate desuccinylase activity
K6752_09055	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K6752_09060	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K6752_09065	COG0702	epimerase
K6752_09070	COG1823	symporter activity
K6752_09075	COG2925	Exonuclease
K6752_09080	COG1380	Effector of murein hydrolase LrgA
K6752_09085	COG1346	cytolysis
K6752_09090	COG0295	cytidine deaminase activity
K6752_09095	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K6752_09100	COG0500	methyltransferase
K6752_09110	COG0776	regulation of translation
K6752_09120	COG0072	phenylalanine-tRNA ligase activity
K6752_09120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6752_09125	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K6752_09160	COG0393	Putative heavy-metal-binding
K6752_09170	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K6752_09180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K6752_09195	COG2188	Transcriptional regulator
K6752_09200	COG1228	amidohydrolase
K6752_09205	COG0010	Belongs to the arginase family
K6752_09210	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K6752_09215	COG2986	histidine ammonia-lyase
K6752_09230	COG0247	lactate metabolic process
K6752_09230	COG0277	FAD linked oxidase domain protein
K6752_09265	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K6752_09280	COG1643	Atp-dependent helicase
K6752_09285	COG0281	malic enzyme
K6752_09290	COG2949	membrane
K6752_09295	COG0471	metal ion transport
K6752_09320	COG0492	ferredoxin-NADP+ reductase activity
K6752_09325	COG4988	ABC transporter
K6752_09330	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K6752_09335	COG3048	D-serine ammonia-lyase activity
K6752_09340	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K6752_09350	COG4191	Histidine kinase
K6752_09350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6752_09365	COG3070	regulator of competence-specific genes
K6752_09375	COG2431	L-lysine efflux transmembrane transporter activity
K6752_09385	COG0076	glutamate decarboxylase activity
K6752_09390	COG1737	Transcriptional regulator
K6752_09400	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K6752_09405	COG2985	domain, Protein
K6752_09405	COG3273	potassium ion transport
K6752_09410	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K6752_09415	COG1960	acyl-CoA dehydrogenase activity
K6752_09425	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K6752_09445	COG0534	Mate efflux family protein
K6752_09450	COG0702	epimerase
K6752_09460	COG2814	Major facilitator Superfamily
K6752_09465	COG1187	pseudouridine synthase activity
K6752_09470	COG1061	Type III restriction enzyme res subunit
K6752_09490	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K6752_09510	COG3313	Fe-S protein
K6752_09520	COG4134	Bacterial extracellular solute-binding protein
K6752_09525	COG4135	transport system, permease component
K6752_09530	COG4136	ATPase activity
K6752_09535	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K6752_09545	COG3604	Transcriptional regulator
K6752_09550	COG1151	hydroxylamine reductase activity
K6752_09555	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K6752_09560	COG0116	Belongs to the methyltransferase superfamily
K6752_09560	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K6752_09565	COG0564	pseudouridine synthase activity
K6752_09570	COG0733	neurotransmitter:sodium symporter activity
K6752_09580	COG0626	cystathionine gamma-synthase activity
K6752_09585	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
K6752_09590	COG5380	lipid catabolic process
K6752_09595	COG2818	Glycosylase
K6752_09615	COG1983	PspC domain protein
K6752_09625	COG1842	Phage shock protein A
K6752_09630	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K6752_09645	COG4171	peptide transport system, permease
K6752_09655	COG4172	Belongs to the ABC transporter superfamily
K6752_09665	COG1227	inorganic diphosphatase activity
K6752_09680	COG0243	molybdopterin cofactor binding
K6752_09685	COG3005	denitrification pathway
K6752_09690	COG4459	periplasmic nitrate reductase
K6752_09695	COG0390	transport system, permease component
K6752_09705	COG2116	formate transmembrane transporter activity
K6752_09735	COG1435	thymidine kinase activity
K6752_09740	COG0215	cysteine-tRNA ligase activity
K6752_09745	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K6752_09750	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6752_09755	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K6752_09760	COG3012	SEC-C Motif Domain Protein
K6752_09765	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K6752_09765	COG0140	phosphoribosyl-ATP diphosphatase activity
K6752_09775	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K6752_09780	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K6752_09785	COG0131	Imidazoleglycerol-phosphate dehydratase
K6752_09785	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K6752_09795	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K6752_09805	COG1757	Na H antiporter
K6752_09815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6752_09830	COG2915	High frequency lysogenization protein hflD homolog
K6752_09835	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K6752_09845	COG2268	Band 7 protein
K6752_09855	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K6752_09870	COG0300	oxidoreductase activity
K6752_09890	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K6752_09910	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K6752_09915	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K6752_09925	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K6752_09935	COG1674	ftsk spoiiie
K6752_09945	COG0686	Belongs to the AlaDH PNT family
K6752_09955	COG0583	DNA-binding transcription factor activity
K6752_09980	COG3568	Endonuclease Exonuclease Phosphatase
K6752_10005	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6752_10010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6752_10030	COG1271	oxidase subunit
K6752_10035	COG1294	oxidase, subunit
K6752_10050	COG5002	protein histidine kinase activity
K6752_10050	COG0784	Response regulator, receiver
K6752_10060	COG0754	glutathionylspermidine amidase activity
K6752_10065	COG5463	Belongs to the UPF0441 family
K6752_10070	COG3766	membrane
K6752_10080	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K6752_10090	COG2885	chlorophyll binding
K6752_10095	COG0823	Involved in the tonB-independent uptake of proteins
K6752_10110	COG0811	peptide transport
K6752_10115	COG0824	Thioesterase
K6752_10125	COG4890	Cyd operon protein YbgT
K6752_10130	COG1294	oxidase, subunit
K6752_10135	COG1271	oxidase subunit
K6752_10140	COG2255	four-way junction helicase activity
K6752_10145	COG0632	four-way junction helicase activity
K6752_10150	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K6752_10155	COG0217	transcriptional regulatory protein
K6752_10165	COG1801	Protein of unknown function DUF72
K6752_10180	COG0189	ligase activity
K6752_10180	COG4067	protein conserved in archaea
K6752_10200	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K6752_10205	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
K6752_10210	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
K6752_10215	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K6752_10220	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K6752_10225	COG0745	RESPONSE REGULATOR receiver
K6752_10230	COG3381	protein complex oligomerization
K6752_10235	COG1609	Transcriptional regulator
K6752_10240	COG3070	regulator of competence-specific genes
K6752_10260	COG0297	glycogen (starch) synthase activity
K6752_10265	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K6752_10270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K6752_10290	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K6752_10295	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K6752_10300	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K6752_10305	COG0542	response to heat
K6752_10310	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K6752_10315	COG1278	Cold shock
K6752_10325	COG1187	pseudouridine synthase activity
K6752_10330	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K6752_10335	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6752_10340	COG1199	ATP-dependent helicase activity
K6752_10345	COG0730	response to heat
K6752_10350	COG3923	Primosomal replication protein n
K6752_10360	COG0708	Exodeoxyribonuclease III
K6752_10400	COG1882	Formate acetyltransferase
K6752_10410	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K6752_10420	COG3013	Belongs to the UPF0304 family
K6752_10425	COG2766	serine protein kinase
K6752_10430	COG2718	Belongs to the UPF0229 family
K6752_10435	COG2719	SpoVR family
K6752_10455	COG1132	(ABC) transporter
K6752_10460	COG2333	competence protein COMEC
K6752_10460	COG0658	competence protein
K6752_10470	COG4591	ABC-type transport system involved in lipoprotein release permease component
K6752_10475	COG1136	(ABC) transporter
K6752_10480	COG4591	ABC-type transport system involved in lipoprotein release permease component
K6752_10490	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K6752_10505	COG1252	NADH dehydrogenase
K6752_10510	COG3150	esterase
K6752_10535	COG0537	adenosine 5'-monophosphoramidase activity
K6752_10560	COG0516	GMP reductase activity
K6752_10560	COG0517	IMP dehydrogenase activity
K6752_10565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6752_10590	COG3126	Type III secretion system lipoprotein chaperone (YscW)
K6752_10595	COG1946	Acyl-CoA thioesterase
K6752_10605	COG1522	sequence-specific DNA binding
K6752_10610	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6752_10625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6752_10630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6752_10675	COG0477	Major facilitator Superfamily
K6752_10680	COG2855	membrane
K6752_10700	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K6752_10710	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K6752_10715	COG1169	isochorismate synthase
K6752_10720	COG0436	Aminotransferase
K6752_10725	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K6752_10730	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K6752_10745	COG1555	photosystem II stabilization
K6752_10750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6752_10755	COG0776	regulation of translation
K6752_10760	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K6752_10765	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K6752_10775	COG0544	peptidyl-prolyl cis-trans isomerase activity
K6752_10790	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K6752_10795	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K6752_10800	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K6752_10805	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K6752_10820	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6752_10825	COG0569	domain protein
K6752_10830	COG0513	Belongs to the DEAD box helicase family
K6752_10865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6752_10870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6752_10885	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K6752_10890	COG1216	Glycosyl transferase, family 2
K6752_10895	COG2986	histidine ammonia-lyase
K6752_10920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K6752_10930	COG1028	Short-chain dehydrogenase reductase Sdr
K6752_10990	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K6752_10995	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6752_11005	COG2951	lytic endotransglycosylase activity
K6752_11010	COG3100	YcgL domain-containing protein
K6752_11015	COG0850	regulation of cytokinetic process
K6752_11020	COG2894	cell division
K6752_11025	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K6752_11030	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K6752_11035	COG0318	PFAM AMP-dependent synthetase and ligase
K6752_11040	COG2267	carboxylic ester hydrolase activity
K6752_11045	COG3065	identical protein binding
K6752_11055	COG1214	PFAM Peptidase M22, glycoprotease
K6752_11060	COG1199	ATP-dependent helicase activity
K6752_11065	COG0788	formyltetrahydrofolate deformylase activity
K6752_11080	COG3102	Protein conserved in bacteria
K6752_11085	COG0018	arginyl-trna synthetase
K6752_11110	COG1918	ferrous iron import across plasma membrane
K6752_11115	COG4977	sequence-specific DNA binding
K6752_11120	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
K6752_11125	COG1121	(ABC) transporter
K6752_11130	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K6752_11140	COG0045	succinate-CoA ligase (ADP-forming) activity
K6752_11145	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6752_11150	COG0567	Dehydrogenase, E1 component
K6752_11155	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K6752_11160	COG1053	succinate dehydrogenase
K6752_11165	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K6752_11180	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K6752_11190	COG0033	Phosphoglucomutase
K6752_11195	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
K6752_11200	COG0596	Alpha beta hydrolase
K6752_11220	COG0735	belongs to the Fur family
K6752_11225	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K6752_11230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6752_11230	COG2190	(PTS) system
K6752_11230	COG1263	PTS System
K6752_11235	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K6752_11240	COG1846	Transcriptional regulator
K6752_11240	COG1940	carbohydrate kinase activity
K6752_11245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K6752_11245	COG4651	solute:proton antiporter activity
K6752_11250	COG0367	asparagine synthase
K6752_11255	COG0250	Participates in transcription elongation, termination and antitermination
K6752_11260	COG3104	oligopeptide transport
K6752_11265	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K6752_11275	COG0326	Molecular chaperone. Has ATPase activity
K6752_11280	COG3710	Transcriptional regulator
K6752_11300	COG0622	Phosphoesterase
K6752_11325	COG1090	epimerase
K6752_11330	COG0300	oxidoreductase activity
K6752_11335	COG3118	belongs to the thioredoxin family
K6752_11345	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
K6752_11355	COG1215	transferase activity, transferring glycosyl groups
K6752_11380	COG2194	sulfuric ester hydrolase activity
K6752_11385	COG0330	HflC and HflK could
K6752_11405	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K6752_11410	COG3115	cell septum assembly
K6752_11415	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
K6752_11420	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6752_11425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6752_11430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K6752_11435	COG2190	(PTS) system
K6752_11440	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6752_11445	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6752_11450	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6752_11455	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6752_11465	COG1705	Flagellar rod assembly protein muramidase FlgJ
K6752_11465	COG3951	Flagellar rod assembly protein muramidase FlgJ
K6752_11470	COG1706	bacterial-type flagellum-dependent cell motility
K6752_11475	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K6752_11485	COG4787	bacterial-type flagellum-dependent cell motility
K6752_11490	COG1749	Flagellar hook protein flgE
K6752_11500	COG1558	bacterial-type flagellum-dependent cell motility
K6752_11505	COG1815	bacterial-type flagellum-dependent cell motility
K6752_11510	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K6752_11515	COG0835	chemotaxis
K6752_11515	COG0784	Response regulator, receiver
K6752_11570	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K6752_11580	COG2217	Heavy metal translocating P-type atpase
K6752_11580	COG2608	mercury ion transmembrane transporter activity
K6752_11620	COG2840	Smr protein MutS2
K6752_11625	COG1187	pseudouridine synthase activity
K6752_11630	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K6752_11635	COG0737	Belongs to the 5'-nucleotidase family
K6752_11640	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K6752_11645	COG2912	Transglutaminase-like superfamily
K6752_11650	COG3094	Invasion gene expression up-regulator, SirB
K6752_11655	COG2890	protein-(glutamine-N5) methyltransferase activity
K6752_11665	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K6752_11670	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K6752_11675	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K6752_11680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K6752_11685	COG0193	aminoacyl-tRNA hydrolase activity
K6752_11690	COG0012	GTP binding
K6752_11795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6752_11800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K6752_11805	COG1702	phosphate starvation-inducible protein PhoH
K6752_11810	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K6752_11815	COG4535	Mg2 and Co2 transporter CorC
K6752_11820	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K6752_11825	COG2888	peptidyl-tyrosine sulfation
K6752_11830	COG0495	leucyl-tRNA aminoacylation
K6752_11835	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
K6752_11840	COG1466	dna polymerase III delta subunit
K6752_11845	COG0799	negative regulation of ribosome biogenesis
K6752_11850	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K6752_11855	COG0768	penicillin binding
K6752_11860	COG0772	Belongs to the SEDS family
K6752_11865	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K6752_11870	COG1686	Belongs to the peptidase S11 family
K6752_11880	COG0321	lipoyl(octanoyl) transferase activity
K6752_11885	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K6752_11890	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K6752_11895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6752_11910	COG0366	Alpha amylase catalytic
K6752_11915	COG1263	PTS System
K6752_11915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6752_11925	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K6752_11930	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K6752_11935	COG2011	ABC-type metal ion transport system permease component
K6752_11940	COG1464	Belongs to the NlpA lipoprotein family
K6752_11945	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
K6752_11955	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K6752_11955	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K6752_11970	COG1611	Belongs to the LOG family
K6752_11975	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6752_11985	COG2363	Small membrane protein
K6752_11995	COG0583	DNA-binding transcription factor activity
K6752_12000	COG0301	tRNA thio-modification
K6752_12000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6752_12010	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K6752_12015	COG1722	exodeoxyribonuclease VII activity
K6752_12020	COG0142	geranyltranstransferase activity
K6752_12025	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K6752_12030	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K6752_12035	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K6752_12045	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K6752_12060	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6752_12060	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6752_12065	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K6752_12070	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K6752_12075	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K6752_12085	COG1073	alpha beta
K6752_12090	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K6752_12095	COG2252	PERMEase
K6752_12100	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6752_12115	COG1629	transport
K6752_12130	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K6752_12130	COG0047	phosphoribosylformylglycinamidine synthase activity
K6752_12135	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K6752_12145	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K6752_12175	COG0484	heat shock protein binding
K6752_12185	COG1301	dicarboxylic acid transport
K6752_12190	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K6752_12195	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K6752_12205	COG0497	DNA recombination
K6752_12215	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6752_12220	COG2914	Belongs to the UPF0125 (RnfH) family
K6752_12225	COG2867	negative regulation of translational initiation
K6752_12230	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K6752_12250	COG0583	DNA-binding transcription factor activity
K6752_12255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6752_12255	COG3153	acetyltransferase
K6752_12275	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K6752_12280	COG2873	o-acetylhomoserine
K6752_12295	COG1115	amino acid carrier protein
K6752_12300	COG1584	GPR1 FUN34 yaaH family protein
K6752_12310	COG1757	Na H antiporter
K6752_12320	COG0517	IMP dehydrogenase activity
K6752_12320	COG0516	GMP reductase activity
K6752_12340	COG1160	GTP binding
K6752_12345	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6752_12350	COG2976	Protein conserved in bacteria
K6752_12355	COG0124	histidyl-tRNA synthetase
K6752_12360	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K6752_12375	COG0105	UTP biosynthetic process
K6752_12385	COG2975	iron-sulfur cluster assembly
K6752_12390	COG0633	Ferredoxin
K6752_12395	COG0443	Heat shock 70 kDa protein
K6752_12410	COG0822	iron-sulfur transferase activity
K6752_12415	COG1104	cysteine desulfurase activity
K6752_12425	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
K6752_12430	COG0483	inositol monophosphate 1-phosphatase activity
K6752_12435	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6752_12440	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6752_12445	COG1862	Preprotein translocase
K6752_12455	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K6752_12465	COG0517	IMP dehydrogenase activity
K6752_12475	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K6752_12480	COG0583	DNA-binding transcription factor activity
K6752_12485	COG0450	alkyl hydroperoxide reductase
K6752_12490	COG3142	Participates in the control of copper homeostasis
K6752_12500	COG0704	Plays a role in the regulation of phosphate uptake
K6752_12505	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K6752_12510	COG0581	inorganic phosphate transmembrane transporter activity
K6752_12515	COG0573	inorganic phosphate transmembrane transporter activity
K6752_12520	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K6752_12525	COG0248	Ppx GppA phosphatase
K6752_12535	COG5002	protein histidine kinase activity
K6752_12540	COG0745	RESPONSE REGULATOR receiver
K6752_12545	COG2974	May be involved in recombination
K6752_12550	COG0826	peptidase U32
K6752_12555	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K6752_12610	COG0542	response to heat
K6752_12620	COG0564	pseudouridine synthase activity
K6752_12625	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6752_12635	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K6752_12640	COG0077	Prephenate dehydratase
K6752_12640	COG1605	Chorismate mutase
K6752_12645	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
K6752_12650	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
K6752_12660	COG0488	(ABC) transporter
K6752_12670	COG0739	heme binding
K6752_12675	COG0287	Prephenate dehydrogenase
K6752_12675	COG1605	Chorismate mutase
K6752_12680	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K6752_12685	COG1472	Belongs to the glycosyl hydrolase 3 family
K6752_12690	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K6752_12710	COG1966	Carbon starvation protein
K6752_12715	COG3275	phosphorelay sensor kinase activity
K6752_12720	COG3279	Response regulator of the LytR AlgR family
K6752_12730	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K6752_12735	COG1047	Peptidyl-prolyl cis-trans
K6752_12750	COG0196	riboflavin kinase activity
K6752_12755	COG0728	peptidoglycan biosynthetic process
K6752_12760	COG0268	Binds directly to 16S ribosomal RNA
K6752_12765	COG0640	Transcriptional regulator
K6752_12770	COG0583	DNA-binding transcription factor activity
K6752_12775	COG1283	sodium-dependent phosphate transmembrane transporter activity
K6752_12785	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K6752_12790	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K6752_12795	COG0730	response to heat
K6752_12820	COG0667	Aldo Keto reductase
K6752_12830	COG2204	response regulator
K6752_12845	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K6752_12850	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K6752_12855	COG4974	Belongs to the 'phage' integrase family
K6752_12860	COG0716	FMN binding
K6752_12870	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K6752_12875	COG0513	Belongs to the DEAD box helicase family
K6752_12880	COG3022	response to hydroperoxide
K6752_12885	COG1115	amino acid carrier protein
K6752_12900	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K6752_12905	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K6752_12910	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
K6752_12920	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K6752_12925	COG0083	homoserine kinase activity
K6752_12945	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K6752_12955	COG0745	RESPONSE REGULATOR receiver
K6752_12965	COG0784	Response regulator, receiver
K6752_12965	COG5002	protein histidine kinase activity
K6752_12965	COG2198	Histidine kinase
K6752_12970	COG4251	negative regulation of phosphorylation
K6752_12970	COG2203	Gaf domain
K6752_12970	COG5001	Diguanylate cyclase
K6752_12970	COG3706	GGDEF domain
K6752_12975	COG1242	4 iron, 4 sulfur cluster binding
K6752_12980	COG0069	glutamate synthase activity
K6752_12980	COG0070	glutamate synthase
K6752_12980	COG0067	glutamate synthase
K6752_12990	COG0070	glutamate synthase
K6752_12990	COG0067	glutamate synthase
K6752_12990	COG0069	glutamate synthase activity
K6752_12995	COG0493	'glutamate synthase
K6752_13005	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K6752_13020	COG2860	membrane
K6752_13025	COG0583	DNA-binding transcription factor activity
K6752_13030	COG0730	response to heat
K6752_13045	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K6752_13050	COG0505	Belongs to the CarA family
K6752_13060	COG0494	nUDIX hydrolase
K6752_13065	COG0653	protein targeting
K6752_13075	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K6752_13080	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K6752_13085	COG0849	cell division
K6752_13090	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K6752_13105	COG0772	Belongs to the SEDS family
K6752_13110	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K6752_13115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6752_13120	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K6752_13125	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K6752_13130	COG0768	penicillin binding
K6752_13135	COG3116	cell division
K6752_13150	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K6752_13165	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K6752_13170	COG2823	Periplasmic or secreted lipoprotein
K6752_13175	COG2969	positive regulation of protein catabolic process
K6752_13180	COG0625	glutathione transferase activity
K6752_13185	COG2857	Cytochrome c1
K6752_13190	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K6752_13195	COG0723	plastoquinol--plastocyanin reductase activity
K6752_13200	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K6752_13210	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K6752_13215	COG3105	Protein conserved in bacteria
K6752_13225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6752_13230	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K6752_13240	COG3150	esterase
K6752_13250	COG3151	Protein conserved in bacteria
K6752_13255	COG0494	nUDIX hydrolase
K6752_13260	COG1538	Outer membrane efflux protein
K6752_13265	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K6752_13265	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K6752_13270	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K6752_13285	COG3025	triphosphatase activity
K6752_13290	COG1392	Phosphate transport regulator
K6752_13295	COG0306	phosphate transporter
K6752_13300	COG4991	sh3 domain protein
K6752_13305	COG0405	Gamma-glutamyltransferase
K6752_13315	COG3267	Type II secretory pathway component ExeA
K6752_13315	COG3409	Peptidoglycan-binding domain 1 protein
K6752_13325	COG1968	undecaprenyl-diphosphatase activity
K6752_13330	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K6752_13335	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K6752_13340	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K6752_13345	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K6752_13350	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K6752_13355	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K6752_13360	COG1610	YqeY-like protein
K6752_13365	COG0358	DNA primase activity
K6752_13400	COG2213	PTS system mannitol-specific
K6752_13400	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6752_13410	COG3722	fumarate hydratase activity
K6752_13425	COG1461	Dihydroxyacetone kinase
K6752_13430	COG2376	Dihydroxyacetone kinase
K6752_13440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K6752_13445	COG1349	DNA-binding transcription factor activity
K6752_13450	COG0469	pyruvate kinase activity
K6752_13465	COG0440	acetolactate synthase activity
K6752_13470	COG0028	Belongs to the TPP enzyme family
K6752_13475	COG1022	Amp-dependent synthetase and ligase
K6752_13480	COG0583	DNA-binding transcription factor activity
K6752_13500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K6752_13505	COG0473	3-isopropylmalate dehydrogenase activity
K6752_13525	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K6752_13530	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K6752_13535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6752_13540	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K6752_13545	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K6752_13550	COG2967	ApaG domain
K6752_13555	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K6752_13560	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K6752_13570	COG2966	Psort location CytoplasmicMembrane, score
K6752_13575	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K6752_13585	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K6752_13590	COG0142	geranyltranstransferase activity
K6752_13610	COG2358	TRAP transporter, solute receptor (TAXI family
K6752_13625	COG1902	pentaerythritol trinitrate reductase activity
K6752_13630	COG0583	DNA-binding transcription factor activity
K6752_13635	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K6752_13640	COG1178	ABC-type Fe3 transport system permease component
K6752_13650	COG0163	prenyltransferase activity
K6752_13655	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K6752_13660	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K6752_13665	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K6752_13675	COG2105	PFAM AIG2 family protein
K6752_13680	COG2911	Protein conserved in bacteria
K6752_13685	COG0729	surface antigen
K6752_13690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6752_13700	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K6752_13715	COG4181	ATPase activity
K6752_13735	COG0529	Catalyzes the synthesis of activated sulfate
K6752_13740	COG0471	metal ion transport
K6752_13740	COG3273	potassium ion transport
K6752_13745	COG2895	sulfate adenylyltransferase (ATP) activity
K6752_13750	COG0175	sulfate reduction
K6752_13755	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K6752_13755	COG1648	precorrin-2 dehydrogenase activity
K6752_13770	COG0513	Belongs to the DEAD box helicase family
K6752_13775	COG2153	protein acetylation
K6752_13785	COG0545	Peptidyl-prolyl cis-trans isomerase
K6752_13795	COG0203	ribosomal protein L17
K6752_13800	COG0202	RNA polymerase activity
K6752_13810	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K6752_13815	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K6752_13820	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K6752_13825	COG0201	protein transport
K6752_13830	COG0200	Binds to the 23S rRNA
K6752_13835	COG1841	ribosomal large subunit assembly
K6752_13850	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K6752_13855	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K6752_13865	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K6752_13870	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K6752_13880	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K6752_13885	COG0255	Belongs to the universal ribosomal protein uL29 family
K6752_13895	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K6752_13900	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K6752_13905	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K6752_13910	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K6752_13920	COG0088	Forms part of the polypeptide exit tunnel
K6752_13925	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K6752_13935	COG0254	rRNA binding
K6752_13940	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K6752_13945	COG1609	Transcriptional regulator
K6752_13955	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K6752_13960	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K6752_13970	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K6752_13980	COG1494	fructose-1,6-bisphosphatase
K6752_14010	COG0149	triose-phosphate isomerase activity
K6752_14060	COG1216	Glycosyl transferase, family 2
K6752_14070	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K6752_14080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6752_14085	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K6752_14090	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6752_14115	COG0438	transferase activity, transferring glycosyl groups
K6752_14130	COG2244	polysaccharide biosynthetic process
K6752_14165	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6752_14175	COG1560	Kdo2-lipid A biosynthetic process
K6752_14185	COG0859	PFAM glycosyl transferase family 9
K6752_14190	COG1519	Transferase
K6752_14195	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K6752_14195	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K6752_14200	COG0367	asparagine synthase
K6752_14230	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K6752_14240	COG3642	lipopolysaccharide core region biosynthetic process
K6752_14245	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K6752_14250	COG0859	PFAM glycosyl transferase family 9
K6752_14255	COG0463	Glycosyl transferase, family 2
K6752_14270	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K6752_14295	COG2003	Belongs to the UPF0758 family
K6752_14305	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K6752_14310	COG1309	transcriptional regulator
K6752_14315	COG1560	Kdo2-lipid A biosynthetic process
K6752_14320	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K6752_14325	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K6752_14330	COG1561	YicC-like family, N-terminal region
K6752_14340	COG4608	Belongs to the ABC transporter superfamily
K6752_14345	COG0444	Belongs to the ABC transporter superfamily
K6752_14350	COG0747	negative chemotaxis
K6752_14355	COG4239	(ABC) transporter, permease
K6752_14360	COG4174	ABC transporter (Permease)
K6752_14380	COG0811	peptide transport
K6752_14385	COG0848	biopolymer transport protein
K6752_14400	COG0194	GDP metabolic process
K6752_14405	COG1758	RNA polymerase activity
K6752_14410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K6752_14415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6752_14420	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K6752_14425	COG2233	PERMEase
K6752_14445	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6752_14455	COG2183	response to ionizing radiation
K6752_14470	COG1040	competence protein
K6752_14480	COG0494	nUDIX hydrolase
K6752_14485	COG1218	3'(2'),5'-bisphosphate nucleotidase
K6752_14495	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K6752_14500	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K6752_14505	COG3156	type II secretion system protein K
K6752_14510	COG4795	General secretion pathway protein
K6752_14515	COG2165	general secretion pathway protein
K6752_14520	COG2165	general secretion pathway protein
K6752_14525	COG2165	general secretion pathway protein
K6752_14530	COG1459	type II secretion system
K6752_14535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K6752_14545	COG3031	protein transport across the cell outer membrane
K6752_14550	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K6752_14555	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K6752_14560	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K6752_14570	COG0456	acetyltransferase
K6752_14575	COG1490	D-aminoacyl-tRNA deacylase activity
K6752_14580	COG1295	ribonuclease BN
K6752_14590	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K6752_14595	COG1217	gtp-binding protein TYPA
K6752_14600	COG0174	glutamine synthetase
K6752_14610	COG3852	Histidine kinase
K6752_14615	COG2204	response regulator
K6752_14625	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K6752_14655	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K6752_14660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6752_14660	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6752_14665	COG0456	acetyltransferase
K6752_14675	COG0084	hydrolase, TatD family'
K6752_14685	COG0805	protein transport
K6752_14690	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K6752_14700	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K6752_14705	COG3165	ubiquinone biosynthetic process from chorismate
K6752_14710	COG2226	methyltransferase
K6752_14715	COG1322	Protein conserved in bacteria
K6752_14730	COG0628	permease
K6752_14760	COG1597	lipid kinase activity
K6752_14790	COG2081	HI0933 family
K6752_14800	COG1528	Iron-storage protein
K6752_14805	COG0589	response to stress
K6752_14820	COG0742	ribosomal rna small subunit methyltransferase
K6752_14825	COG5002	protein histidine kinase activity
K6752_14825	COG5001	Diguanylate cyclase
K6752_14830	COG1522	sequence-specific DNA binding
K6752_14840	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K6752_14845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6752_14850	COG0583	DNA-binding transcription factor activity
K6752_14855	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K6752_14860	COG0800	Aldolase
K6752_14865	COG2610	gluconate transmembrane transporter activity
K6752_14870	COG3265	gluconokinase activity
K6752_14875	COG0129	dihydroxy-acid dehydratase activity
K6752_14890	COG0583	DNA-binding transcription factor activity
K6752_14895	COG1609	Transcriptional regulator
K6752_14930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6752_14935	COG0601	transmembrane transport
K6752_14940	COG4166	transmembrane transport
K6752_14995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6752_15000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6752_15005	COG2960	long-chain fatty acid transporting porin activity
K6752_15010	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K6752_15015	COG0583	DNA-binding transcription factor activity
K6752_15050	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K6752_15065	COG0408	coproporphyrinogen oxidase activity
K6752_15070	COG0009	L-threonylcarbamoyladenylate synthase
K6752_15075	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K6752_15080	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K6752_15085	COG0551	DNA topoisomerase type I activity
K6752_15090	COG2922	Belongs to the Smg family
K6752_15095	COG0758	DNA mediated transformation
K6752_15105	COG0242	peptide deformylase activity
K6752_15110	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K6752_15115	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K6752_15115	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K6752_15120	COG0569	domain protein
K6752_15125	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6752_15135	COG1272	protein, Hemolysin III
K6752_15140	COG4326	sporulation control protein
K6752_15150	COG3084	Protein conserved in bacteria
K6752_15160	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K6752_15165	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K6752_15170	COG0204	Acyl-transferase
K6752_15180	COG0606	chelatase, subunit chli
K6752_15190	COG3978	acetolactate synthase activity
K6752_15195	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6752_15200	COG0129	dihydroxy-acid dehydratase activity
K6752_15210	COG0583	DNA-binding transcription factor activity
K6752_15215	COG2814	Major facilitator Superfamily
K6752_15225	COG0765	amino acid transport
K6752_15235	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K6752_15240	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K6752_15245	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K6752_15250	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K6752_15255	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K6752_15260	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K6752_15270	COG0356	it plays a direct role in the translocation of protons across the membrane
K6752_15275	COG3312	ion transport
K6752_15280	COG1475	DNA binding
K6752_15285	COG1192	Involved in chromosome partitioning
K6752_15290	COG0357	Ribosomal RNA small subunit methyltransferase G
K6752_15295	COG0445	tRNA wobble uridine modification
K6752_15300	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K6752_15310	COG0706	membrane insertase activity
K6752_15320	COG0594	ribonuclease P activity
K6752_15330	COG1126	abc transporter atp-binding protein
K6752_15345	COG4303	Ethanolamine ammonia lyase large subunit
K6752_15350	COG4302	ethanolamine ammonia-lyase activity
K6752_15355	COG0531	amino acid
K6752_15360	COG2070	2-Nitropropane dioxygenase
K6752_15370	COG1349	DNA-binding transcription factor activity
K6752_15385	COG1335	isochorismatase
K6752_15395	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K6752_15420	COG0583	DNA-binding transcription factor activity
K6752_15435	COG3713	MltA-interacting MipA family protein
K6752_15440	COG3015	lipoprotein NlpE involved in copper resistance
K6752_15445	COG4175	Glycine betaine
K6752_15445	COG3448	diguanylate cyclase activity
K6752_15450	COG4176	ABC-type proline glycine betaine transport system permease component
K6752_15455	COG1342	Belongs to the UPF0251 family
K6752_15485	COG4948	Mandelate Racemase Muconate Lactonizing
K6752_15495	COG0583	DNA-binding transcription factor activity
K6752_15530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6752_15560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6752_15580	COG3842	ATPase activity
K6752_15610	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6752_15635	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K6752_15640	COG2197	response regulator
K6752_15655	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K6752_15660	COG0252	asparaginase activity
K6752_15665	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K6752_15670	COG0583	DNA-binding transcription factor activity
K6752_15685	COG3122	Protein conserved in bacteria
K6752_15690	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K6752_15695	COG1012	belongs to the aldehyde dehydrogenase family
K6752_15700	COG1522	sequence-specific DNA binding
K6752_15705	COG3608	succinylglutamate desuccinylase aspartoacylase
K6752_15710	COG0006	proline dipeptidase activity
K6752_15715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6752_15725	COG1028	Short-chain dehydrogenase reductase Sdr
K6752_15735	COG1063	alcohol dehydrogenase
K6752_15740	COG1902	pentaerythritol trinitrate reductase activity
K6752_15755	COG0583	DNA-binding transcription factor activity
K6752_15765	COG0513	Belongs to the DEAD box helicase family
K6752_15785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6752_15790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6752_15790	COG2207	Transcriptional regulator
K6752_15795	COG0583	DNA-binding transcription factor activity
K6752_15800	COG0300	oxidoreductase activity
K6752_15815	COG3746	phosphate-selective porin O and P
K6752_15830	COG1028	Short-chain dehydrogenase reductase Sdr
K6752_15835	COG1404	Belongs to the peptidase S8 family
K6752_15865	COG1263	PTS System
K6752_15865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6752_15870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6752_15875	COG1621	beta-fructofuranosidase activity
K6752_15880	COG0625	glutathione transferase activity
K6752_15885	COG1686	Belongs to the peptidase S11 family
K6752_15895	COG0678	peroxiredoxin activity
K6752_15895	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K6752_15900	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K6752_15915	COG1278	Cold shock
K6752_15920	COG1741	Belongs to the pirin family
K6752_15925	COG4667	esterase of the alpha-beta hydrolase superfamily
K6752_15945	COG2194	sulfuric ester hydrolase activity
K6752_15950	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K6752_15960	COG2205	protein histidine kinase activity
K6752_15965	COG0745	RESPONSE REGULATOR receiver
K6752_15980	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K6752_16000	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6752_16010	COG2814	Major facilitator Superfamily
K6752_16020	COG1418	mRNA catabolic process
K6752_16025	COG0402	S-adenosylhomocysteine deaminase activity
K6752_16030	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K6752_16035	COG2239	Acts as a magnesium transporter
K6752_16040	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K6752_16045	COG1566	PFAM secretion protein HlyD family protein
K6752_16070	COG0745	RESPONSE REGULATOR receiver
K6752_16075	COG2205	protein histidine kinase activity
K6752_16090	COG0531	amino acid
K6752_16100	COG0583	DNA-binding transcription factor activity
K6752_16125	COG2205	protein histidine kinase activity
K6752_16125	COG0784	Response regulator, receiver
K6752_16125	COG5002	protein histidine kinase activity
K6752_16145	COG3132	Protein of unknown function, DUF480
K6752_16150	COG2827	Endonuclease containing a URI domain
K6752_16155	COG1879	ABC-type sugar transport system periplasmic component
K6752_16160	COG0784	Response regulator, receiver
K6752_16160	COG2205	protein histidine kinase activity
K6752_16165	COG1846	Transcriptional regulator
K6752_16170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6752_16215	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6752_16220	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6752_16230	COG1280	lysine exporter protein (LysE YggA)
K6752_16240	COG0183	Belongs to the thiolase family
K6752_16250	COG3243	poly(R)-hydroxyalkanoic acid synthase
K6752_16260	COG3005	denitrification pathway
K6752_16270	COG0243	molybdopterin cofactor binding
K6752_16280	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K6752_16285	COG3850	Histidine kinase
K6752_16290	COG2197	response regulator
K6752_16305	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6752_16325	COG0840	transmembrane signaling receptor activity
K6752_16335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6752_16350	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K6752_16355	COG2814	Major facilitator Superfamily
K6752_16360	COG0840	transmembrane signaling receptor activity
K6752_16365	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K6752_16370	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K6752_16380	COG2897	thiosulfate sulfurtransferase activity
K6752_16415	COG0038	chloride channel
K6752_16430	COG4989	oxidoreductase activity
K6752_16445	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K6752_16445	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K6752_16455	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K6752_16500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6752_16515	COG0739	heme binding
K6752_16540	COG2204	response regulator
K6752_16555	COG3501	Rhs element vgr protein
K6752_16580	COG0515	serine threonine protein kinase
K6752_16615	COG1522	sequence-specific DNA binding
K6752_16680	COG2814	Major facilitator Superfamily
K6752_16690	COG0583	DNA-binding transcription factor activity
K6752_16695	COG4221	oxidoreductase activity
K6752_16700	COG0589	response to stress
K6752_16710	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K6752_16710	COG2111	Na H antiporter
K6752_16715	COG1006	Multisubunit Na H antiporter MnhC subunit
K6752_16720	COG0651	ATP synthesis coupled electron transport
K6752_16725	COG1863	multisubunit Na H antiporter MnhE subunit
K6752_16730	COG2212	antiporter activity
K6752_16735	COG1320	monovalent cation:proton antiporter activity
K6752_16740	COG2188	Transcriptional regulator
K6752_16745	COG1486	melibiose metabolic process
K6752_16750	COG1263	PTS System
K6752_16750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6752_16755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6752_16780	COG1022	Amp-dependent synthetase and ligase
K6752_16810	COG0500	methyltransferase
K6752_16825	COG3527	Alpha-acetolactate decarboxylase
K6752_16835	COG0384	phenazine biosynthesis protein PhzF
K6752_16845	COG1294	oxidase, subunit
K6752_16850	COG1271	oxidase subunit
K6752_16855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6752_16860	COG0110	maltose O-acetyltransferase activity
K6752_16865	COG3264	Mechanosensitive ion channel
K6752_16865	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K6752_16880	COG4770	biotin carboxylase activity
K6752_16885	COG1024	Enoyl-CoA hydratase
K6752_16890	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K6752_16895	COG1960	acyl-CoA dehydrogenase activity
K6752_16905	COG0183	Belongs to the thiolase family
K6752_16915	COG1960	acyl-CoA dehydrogenase activity
K6752_16920	COG1024	Enoyl-CoA hydratase
K6752_16935	COG1028	Short-chain dehydrogenase reductase Sdr
K6752_16945	COG1309	transcriptional regulator
K6752_16950	COG1012	belongs to the aldehyde dehydrogenase family
K6752_16965	COG4176	ABC-type proline glycine betaine transport system permease component
K6752_16970	COG0517	IMP dehydrogenase activity
K6752_16970	COG4175	Glycine betaine
K6752_16985	COG0330	HflC and HflK could
K6752_17000	COG2205	protein histidine kinase activity
K6752_17000	COG0784	Response regulator, receiver
K6752_17010	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K6752_17065	COG5001	Diguanylate cyclase
K6752_17070	COG1869	D-ribose catabolic process
K6752_17075	COG1129	ABC transporter
K6752_17080	COG1172	Belongs to the binding-protein-dependent transport system permease family
K6752_17085	COG1879	ABC-type sugar transport system periplasmic component
K6752_17090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6752_17095	COG1609	Transcriptional regulator
K6752_17105	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
K6752_17115	COG4607	ABC-type enterochelin transport system periplasmic component
K6752_17120	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6752_17125	COG4605	iron ion homeostasis
K6752_17130	COG4604	ABC transporter, ATP-binding protein
K6752_17135	COG0789	Transcriptional regulator
K6752_17145	COG4771	TonB-dependent receptor
K6752_17145	COG1629	transport
K6752_17175	COG1289	transmembrane transporter activity
K6752_17180	COG0210	DNA helicase
K6752_17185	COG1803	Methylglyoxal synthase
K6752_17190	COG1879	ABC-type sugar transport system periplasmic component
K6752_17195	COG2205	protein histidine kinase activity
K6752_17195	COG0784	Response regulator, receiver
K6752_17195	COG2198	Histidine kinase
K6752_17210	COG0745	RESPONSE REGULATOR receiver
K6752_17215	COG3119	arylsulfatase activity
K6752_17225	COG3119	arylsulfatase activity
K6752_17230	COG0641	radical SAM
K6752_17235	COG0714	Associated with various cellular activities
K6752_17265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6752_17270	COG0583	DNA-binding transcription factor activity
K6752_17275	COG1597	lipid kinase activity
K6752_17280	COG3111	PFAM Bacterial OB fold (BOF) protein
K6752_17305	COG3069	C4-dicarboxylate transmembrane transporter activity
K6752_17315	COG0456	acetyltransferase
K6752_17315	COG1214	PFAM Peptidase M22, glycoprotease
K6752_17335	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K6752_17340	COG2205	protein histidine kinase activity
K6752_17340	COG0784	Response regulator, receiver
K6752_17345	COG5001	Diguanylate cyclase
K6752_17345	COG3300	MHYT domain
K6752_17350	COG2197	response regulator
K6752_17355	COG3706	GGDEF domain
K6752_17365	COG2197	response regulator
K6752_17370	COG0784	Response regulator, receiver
K6752_17370	COG0835	chemotaxis
K6752_17385	COG2962	Rard protein
K6752_17405	COG2076	Multidrug Resistance protein
K6752_17440	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K6752_17445	COG5642	Protein of unknown function (DUF2384)
K6752_17455	COG2755	lipolytic protein G-D-S-L family
K6752_17455	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K6752_17465	COG1902	pentaerythritol trinitrate reductase activity
K6752_17470	COG0346	lactoylglutathione lyase activity
K6752_17490	COG2239	Acts as a magnesium transporter
K6752_17515	COG0242	peptide deformylase activity
K6752_17555	COG2176	DNA-directed DNA polymerase activity
K6752_17590	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K6752_17595	COG0697	spore germination
K6752_17600	COG0583	DNA-binding transcription factor activity
K6752_17605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6752_17610	COG0346	lactoylglutathione lyase activity
K6752_17620	COG0509	glycine decarboxylation via glycine cleavage system
K6752_17625	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K6752_17635	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K6752_17665	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K6752_17665	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K6752_17665	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
K6752_17670	COG1105	Belongs to the carbohydrate kinase PfkB family
K6752_17675	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6752_17675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6752_17680	COG1609	Transcriptional regulator
K6752_17695	COG2200	EAL domain
K6752_17695	COG2203	Gaf domain
K6752_17695	COG2199	diguanylate cyclase activity
K6752_17700	COG0765	amino acid transport
K6752_17705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6752_17710	COG0765	amino acid transport
K6752_17715	COG1126	abc transporter atp-binding protein
K6752_17725	COG1979	alcohol dehydrogenase
K6752_17730	COG2207	Transcriptional regulator
K6752_17740	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K6752_17745	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K6752_17750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6752_17765	COG0546	phosphoglycolate phosphatase activity
K6752_17770	COG0840	transmembrane signaling receptor activity
K6752_17780	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
K6752_17785	COG0513	Belongs to the DEAD box helicase family
K6752_17805	COG3038	cytochrome b561
K6752_17810	COG2353	YceI-like domain
K6752_17815	COG2116	formate transmembrane transporter activity
K6752_17820	COG0583	DNA-binding transcription factor activity
K6752_17830	COG3593	DNA synthesis involved in DNA repair
K6752_17835	COG0737	Belongs to the 5'-nucleotidase family
K6752_17860	COG2267	carboxylic ester hydrolase activity
K6752_17865	COG2067	long-chain fatty acid transport protein
K6752_17875	COG0501	Belongs to the peptidase M48B family
K6752_17880	COG2050	protein possibly involved in aromatic compounds catabolism
K6752_17890	COG4533	DNA binding
K6752_17925	COG5001	Diguanylate cyclase
K6752_17925	COG3300	MHYT domain
K6752_17930	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K6752_17940	COG4181	ATPase activity
K6752_17945	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K6752_17955	COG1984	allophanate hydrolase subunit 2
K6752_17960	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K6752_17965	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K6752_17970	COG5001	Diguanylate cyclase
K6752_17970	COG5002	protein histidine kinase activity
K6752_17970	COG3447	MASE1 domain protein
K6752_17985	COG0583	DNA-binding transcription factor activity
K6752_17990	COG1042	CoA-binding domain protein
K6752_17990	COG0045	succinate-CoA ligase (ADP-forming) activity
K6752_17990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6752_18000	COG1181	Belongs to the D-alanine--D-alanine ligase family
K6752_18010	COG0023	Translation Initiation Factor
K6752_18060	COG4128	Pfam Zonular occludens toxin
K6752_18065	COG4133	protoheme IX ABC transporter activity
K6752_18090	COG0583	DNA-binding transcription factor activity
K6752_18105	COG3140	Belongs to the UPF0181 family
K6752_18130	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K6752_18135	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K6752_18155	COG5001	Diguanylate cyclase
K6752_18155	COG4251	negative regulation of phosphorylation
K6752_18155	COG3706	GGDEF domain
K6752_18155	COG2203	Gaf domain
K6752_18165	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K6752_18170	COG4149	molybdate abc transporter
K6752_18175	COG0725	ABC transporter, periplasmic molybdate-binding protein
K6752_18185	COG3111	PFAM Bacterial OB fold (BOF) protein
K6752_18195	COG0189	ligase activity
K6752_18195	COG4067	protein conserved in archaea
K6752_18205	COG2207	Transcriptional regulator
K6752_18210	COG0534	Mate efflux family protein
K6752_18215	COG0602	queuosine metabolic process
K6752_18220	COG1328	CTP reductase activity
K6752_18250	COG1794	racemase activity, acting on amino acids and derivatives
K6752_18255	COG0384	phenazine biosynthesis protein PhzF
K6752_18270	COG0243	molybdopterin cofactor binding
K6752_18275	COG0583	DNA-binding transcription factor activity
K6752_18280	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K6752_18290	COG2197	response regulator
K6752_18295	COG3851	Histidine kinase
K6752_18300	COG2271	Major facilitator Superfamily
K6752_18325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6752_18330	COG3118	belongs to the thioredoxin family
K6752_18365	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K6752_18385	COG2116	formate transmembrane transporter activity
K6752_18395	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6752_18400	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6752_18420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K6752_18470	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K6752_18485	COG0277	FAD linked oxidase domain protein
K6752_18490	COG0583	DNA-binding transcription factor activity
K6752_18505	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K6752_18520	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
K6752_18530	COG1288	antiporter activity
K6752_18540	COG3040	lipid binding
K6752_18550	COG0419	ATPase involved in DNA repair
K6752_18555	COG0420	3'-5' exonuclease activity
K6752_18625	COG0631	protein serine/threonine phosphatase activity
K6752_18660	COG2815	serine threonine protein kinase
K6752_18660	COG0515	serine threonine protein kinase
K6752_18710	COG2146	nitrite reductase [NAD(P)H] activity
K6752_18710	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6752_18715	COG1116	anion transmembrane transporter activity
K6752_18720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6752_18725	COG1116	anion transmembrane transporter activity
K6752_18725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K6752_18750	COG0243	molybdopterin cofactor binding
K6752_18760	COG0814	amino acid
K6752_18820	COG2847	Copper chaperone PCu(A)C
K6752_18825	COG0443	Heat shock 70 kDa protein
K6752_18895	COG4160	amino acid transport
K6752_18900	COG4215	(ABC) transporter
K6752_18905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6752_18910	COG1126	abc transporter atp-binding protein
K6752_18940	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6752_18950	COG1012	belongs to the aldehyde dehydrogenase family
K6752_18965	COG0446	pyridine nucleotide-disulphide oxidoreductase
K6752_18965	COG1902	pentaerythritol trinitrate reductase activity
K6752_18970	COG0109	protoheme IX farnesyltransferase activity
K6752_18975	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K6752_18980	COG1845	cytochrome c oxidase, subunit III
K6752_18985	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K6752_18990	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K6752_18995	COG1028	Short-chain dehydrogenase reductase Sdr
K6752_19005	COG1024	Enoyl-CoA hydratase
K6752_19010	COG1024	Enoyl-CoA hydratase
K6752_19025	COG0183	Belongs to the thiolase family
K6752_19030	COG0789	Transcriptional regulator
K6752_19035	COG1960	acyl-CoA dehydrogenase activity
K6752_19040	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K6752_19045	COG1024	Enoyl-CoA hydratase
K6752_19075	COG2095	MarC family integral membrane protein
K6752_19090	COG0523	cobalamin synthesis protein
K6752_19095	COG0739	heme binding
K6752_19100	COG2988	succinylglutamate desuccinylase activity
K6752_19105	COG0523	cobalamin synthesis protein
K6752_19115	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K6752_19120	COG0735	belongs to the Fur family
K6752_19135	COG0730	response to heat
K6752_19150	COG1073	alpha beta
K6752_19155	COG1073	alpha beta
K6752_19170	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K6752_19180	COG0513	Belongs to the DEAD box helicase family
K6752_19185	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
K6752_19250	COG1196	nuclear chromosome segregation
K6752_19265	COG1119	ATPase activity
K6752_19270	COG2200	EAL domain
K6752_19290	COG0513	Belongs to the DEAD box helicase family
K6752_19295	COG0523	cobalamin synthesis protein
K6752_19305	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
K6752_19315	COG1278	Cold shock
K6752_19325	COG0133	tryptophan synthase activity
K6752_19335	COG4628	conserved protein (DUF2132)
K6752_19340	COG0513	Belongs to the DEAD box helicase family
K6752_19430	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
K6752_19435	COG0732	type I restriction modification DNA specificity domain
K6752_19450	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K6752_19480	COG3530	Putative quorum-sensing-regulated virulence factor
K6752_19505	COG3186	Phenylalanine-4-hydroxylase
K6752_19510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6752_19515	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K6752_19540	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
K6752_19545	COG1454	alcohol dehydrogenase
K6752_19550	COG2133	pyrroloquinoline quinone binding
K6752_19560	COG0783	Belongs to the Dps family
K6752_19565	COG0840	transmembrane signaling receptor activity
K6752_19590	COG0784	Response regulator, receiver
K6752_19590	COG2205	protein histidine kinase activity
K6752_19595	COG1538	Outer membrane efflux protein
K6752_19620	COG2199	diguanylate cyclase activity
K6752_19625	COG3036	rescue of stalled ribosome
K6752_19630	COG1278	Cold shock
K6752_19660	COG0545	Peptidyl-prolyl cis-trans isomerase
K6752_19665	COG0109	protoheme IX farnesyltransferase activity
K6752_19670	COG1612	heme a metabolic process
K6752_19690	COG1845	cytochrome c oxidase, subunit III
K6752_19695	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K6752_19700	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K6752_19705	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K6752_19710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6752_19720	COG1280	lysine exporter protein (LysE YggA)
K6752_19740	COG0179	Fumarylacetoacetate (FAA) hydrolase
K6752_19750	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6752_19755	COG0697	spore germination
K6752_19770	COG2814	Major facilitator Superfamily
K6752_19775	COG0583	DNA-binding transcription factor activity
K6752_19780	COG5001	Diguanylate cyclase
K6752_19785	COG0739	heme binding
K6752_19805	COG3314	Sporulation integral membrane protein YlbJ
K6752_19820	COG0814	amino acid
K6752_19845	COG4989	oxidoreductase activity
K6752_19870	COG1733	regulation of RNA biosynthetic process
K6752_19885	COG0798	PFAM Bile acid sodium symporter
K6752_19895	COG1881	PFAM PEBP family protein
K6752_19910	COG1131	(ABC) transporter
K6752_19915	COG0842	Transport permease protein
K6752_19925	COG3383	formate dehydrogenase (NAD+) activity
K6752_19945	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6752_19970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6752_19980	COG2067	long-chain fatty acid transport protein
K6752_19990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6752_20000	COG1505	serine-type exopeptidase activity
K6752_20005	COG0488	(ABC) transporter
K6752_20010	COG0589	response to stress
K6752_20015	COG2249	NAD(P)H dehydrogenase (quinone) activity
K6752_20035	COG0366	Alpha amylase catalytic
K6752_20040	COG0789	Transcriptional regulator
K6752_20045	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K6752_20055	COG4934	collagen metabolic process
K6752_20065	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K6752_20070	COG0583	DNA-binding transcription factor activity
K6752_20090	COG2610	gluconate transmembrane transporter activity
K6752_20095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6752_20100	COG3622	Belongs to the hyi family
K6752_20105	COG0235	Class ii aldolase
K6752_20110	COG3395	kinase activity
K6752_20115	COG2084	Dehydrogenase
K6752_20120	COG1349	DNA-binding transcription factor activity
K6752_20130	COG0747	negative chemotaxis
K6752_20135	COG4608	Belongs to the ABC transporter superfamily
K6752_20140	COG0444	Belongs to the ABC transporter superfamily
K6752_20145	COG0534	Mate efflux family protein
K6752_20150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6752_20155	COG0784	Response regulator, receiver
K6752_20155	COG0835	chemotaxis
K6752_20165	COG0748	coenzyme F420 binding
K6752_20170	COG3721	Heme iron utilization protein
K6752_20180	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K6752_20185	COG0811	peptide transport
K6752_20190	COG0848	biopolymer transport protein
K6752_20200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6752_20205	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K6752_20245	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K6752_20255	COG0633	Ferredoxin
K6752_20255	COG3217	Mosc domain protein beta barrel domain protein
K6752_20255	COG0633	Ferredoxin
K6752_20255	COG3217	Mosc domain protein beta barrel domain protein
K6752_20260	COG0401	homolog of Blt101
K6752_20265	COG0418	dihydroorotase activity
K6752_20270	COG2354	Protein conserved in bacteria
K6752_20280	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6752_20285	COG4605	iron ion homeostasis
K6752_20290	COG4607	ABC-type enterochelin transport system periplasmic component
K6752_20295	COG4774	siderophore transport
K6752_20300	COG1132	(ABC) transporter
K6752_20300	COG2375	cellular response to nickel ion
K6752_20330	COG3833	ABC-type maltose transport systems, permease component
K6752_20335	COG1175	transmembrane transport
K6752_20345	COG3842	ATPase activity
K6752_20350	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6752_20365	COG3206	protein involved in exopolysaccharide biosynthesis
K6752_20365	COG0489	protein tyrosine kinase activity
K6752_20405	COG3097	Belongs to the UPF0267 family
K6752_20410	COG1309	transcriptional regulator
K6752_20415	COG2130	NADP-dependent
K6752_20425	COG0753	catalase activity
K6752_20430	COG2084	Dehydrogenase
K6752_20460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6752_20465	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
K6752_20475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6752_20480	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6752_20485	COG1012	belongs to the aldehyde dehydrogenase family
K6752_20505	COG0583	DNA-binding transcription factor activity
K6752_20510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6752_20515	COG0569	domain protein
K6752_20520	COG0745	RESPONSE REGULATOR receiver
K6752_20525	COG2205	protein histidine kinase activity
K6752_20525	COG2205	protein histidine kinase activity
K6752_20530	COG1132	(ABC) transporter
K6752_20535	COG4774	siderophore transport
K6752_20540	COG1120	ATPase activity
K6752_20545	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K6752_20580	COG2197	response regulator
K6752_20595	COG0714	Associated with various cellular activities
K6752_20615	COG2304	oxidoreductase activity
K6752_20630	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K6752_20635	COG0581	inorganic phosphate transmembrane transporter activity
K6752_20640	COG0573	inorganic phosphate transmembrane transporter activity
K6752_20670	COG4771	TonB-dependent receptor
K6752_20675	COG1770	oligopeptidase
K6752_20680	COG0513	Belongs to the DEAD box helicase family
K6752_20690	COG1388	LysM domain
K6752_20690	COG1376	ErfK ybiS ycfS ynhG family protein
K6752_20695	COG0415	Belongs to the DNA photolyase family
K6752_20700	COG0789	Transcriptional regulator
K6752_20705	COG3272	Protein of unknown function (DUF1722)
K6752_20710	COG0813	purine-nucleoside phosphorylase activity
K6752_20735	COG1566	PFAM secretion protein HlyD family protein
K6752_20740	COG4720	Psort location CytoplasmicMembrane, score
K6752_20745	COG1122	ATPase activity
K6752_20765	COG0348	domain, Protein
K6752_20770	COG0437	4 iron, 4 sulfur cluster binding
K6752_20775	COG1247	-acetyltransferase
K6752_20795	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6752_20805	COG1067	ATP-dependent peptidase activity
K6752_20815	COG4172	Belongs to the ABC transporter superfamily
K6752_20820	COG1505	serine-type exopeptidase activity
K6752_20825	COG0583	DNA-binding transcription factor activity
K6752_20830	COG1620	l-lactate permease
K6752_20835	COG1304	FMN binding
K6752_20845	COG0668	transmembrane transport
K6752_20880	COG1063	alcohol dehydrogenase
K6752_20885	COG0156	8-amino-7-oxononanoate synthase activity
K6752_20890	COG5001	Diguanylate cyclase
K6752_20890	COG3300	MHYT domain
K6752_20915	COG0745	RESPONSE REGULATOR receiver
K6752_20940	COG0346	lactoylglutathione lyase activity
K6752_21000	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K6752_21040	COG1987	bacterial-type flagellum assembly
K6752_21050	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K6752_21065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6752_21075	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K6752_21080	COG1516	flagellar protein fliS
K6752_21095	COG1580	Controls the rotational direction of flagella during chemotaxis
K6752_21100	COG1191	sigma factor activity
K6752_21105	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K6752_21110	COG1360	Flagellar Motor Protein
K6752_21140	COG1882	Formate acetyltransferase
K6752_21145	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K6752_21150	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K6752_21165	COG2205	protein histidine kinase activity
K6752_21170	COG0745	RESPONSE REGULATOR receiver
K6752_21180	COG0454	-acetyltransferase
K6752_21190	COG2814	Major facilitator Superfamily
K6752_21205	COG1289	transmembrane transporter activity
K6752_21230	COG0628	permease
K6752_21235	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K6752_21255	COG4628	conserved protein (DUF2132)
K6752_21260	COG0583	DNA-binding transcription factor activity
K6752_21285	COG1686	Belongs to the peptidase S11 family
K6752_21295	COG1054	Belongs to the UPF0176 family
K6752_21305	COG0415	Belongs to the DNA photolyase family
K6752_21310	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K6752_21315	COG3397	chitin binding
K6752_21320	COG4667	esterase of the alpha-beta hydrolase superfamily
K6752_21325	COG2095	MarC family integral membrane protein
K6752_21340	COG1596	polysaccharide export
K6752_21345	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K6752_21365	COG0583	DNA-binding transcription factor activity
K6752_21375	COG1301	dicarboxylic acid transport
K6752_21380	COG3339	Conserved Protein
K6752_21385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6752_21390	COG0700	Nucleoside recognition
K6752_21395	COG3366	ferrous iron transmembrane transporter activity
K6752_21410	COG0366	Alpha amylase catalytic
K6752_21415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6752_21420	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K6752_21425	COG1640	4-alpha-glucanotransferase
K6752_21430	COG0058	SHG alpha-glucan phosphorylase activity
K6752_21435	COG2909	trisaccharide binding
K6752_21450	COG1999	signal sequence binding
K6752_21455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6752_21455	COG1263	PTS System
K6752_21460	COG1162	GTPase activity
K6752_21465	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
K6752_21470	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K6752_21480	COG0531	amino acid
K6752_21485	COG1982	Orn Lys Arg decarboxylase major
K6752_21505	COG2356	endonuclease I
K6752_21525	COG4580	involved in the transport of maltose and maltodextrins
K6752_21535	COG1760	l-serine dehydratase
K6752_21575	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K6752_21585	COG1609	Transcriptional regulator
K6752_21590	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K6752_21600	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K6752_21600	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K6752_21615	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6752_21620	COG1609	Transcriptional regulator
K6752_21630	COG2814	Major facilitator Superfamily
K6752_21645	COG0739	heme binding
K6752_21655	COG0612	Peptidase, M16
K6752_21660	COG0840	transmembrane signaling receptor activity
K6752_21665	COG1120	ATPase activity
K6752_21670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6752_21675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6752_21680	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K6752_21685	COG4772	TonB-dependent receptor
K6752_21710	COG4264	IucA IucC family
K6752_21715	COG0019	diaminopimelate decarboxylase activity
K6752_21725	COG0826	peptidase U32
K6752_21735	COG1136	(ABC) transporter
K6752_21740	COG0577	efflux transmembrane transporter activity
K6752_21775	COG1764	response to oxidative stress
K6752_21780	COG1846	Transcriptional regulator
K6752_21790	COG3634	alkyl hydroperoxide reductase activity
K6752_21835	COG2258	MOSC domain
K6752_21840	COG0513	Belongs to the DEAD box helicase family
K6752_21850	COG1132	(ABC) transporter
K6752_21885	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6752_21910	COG0259	pyridoxamine-phosphate oxidase activity
K6752_21960	COG4166	transmembrane transport
K6752_21975	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K6752_21985	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6752_21990	COG3340	Belongs to the peptidase S51 family
K6752_22010	COG1444	tRNA N-acetyltransferase activity
K6752_22035	COG4608	Belongs to the ABC transporter superfamily
K6752_22040	COG0444	Belongs to the ABC transporter superfamily
K6752_22050	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
K6752_22050	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6752_22075	COG0772	Belongs to the SEDS family
K6752_22085	COG1136	(ABC) transporter
K6752_22105	COG3275	phosphorelay sensor kinase activity
K6752_22110	COG3279	Response regulator of the LytR AlgR family
K6752_22120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K6752_22140	COG0786	glutamate:sodium symporter activity
K6752_22150	COG1131	(ABC) transporter
K6752_22155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6752_22160	COG0786	glutamate:sodium symporter activity
K6752_22170	COG0363	glucosamine-6-phosphate deaminase activity
K6752_22190	COG1741	Belongs to the pirin family
K6752_22195	COG2259	Doxx family
K6752_22205	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K6752_22205	COG2169	Transcriptional regulator
K6752_22210	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K6752_22220	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6752_22245	COG0596	Alpha beta hydrolase
K6752_22260	COG3123	guanosine phosphorylase activity
K6752_22270	COG5001	Diguanylate cyclase
K6752_22275	COG0534	Mate efflux family protein
K6752_22280	COG0564	pseudouridine synthase activity
K6752_22295	COG0583	DNA-binding transcription factor activity
K6752_22300	COG0561	phosphatase activity
K6752_22310	COG2199	diguanylate cyclase activity
K6752_22325	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K6752_22330	COG2162	N-hydroxyarylamine O-acetyltransferase activity
K6752_22335	COG0583	DNA-binding transcription factor activity
K6752_22340	COG2375	cellular response to nickel ion
K6752_22370	COG1357	PFAM Pentapeptide repeats (8 copies)
K6752_22375	COG3047	cAMP biosynthetic process
K6752_22435	COG3835	regulator
K6752_22440	COG2610	gluconate transmembrane transporter activity
K6752_22445	COG1929	Belongs to the glycerate kinase type-1 family
K6752_22450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6752_22470	COG0456	acetyltransferase
K6752_22485	COG1028	Short-chain dehydrogenase reductase Sdr
K6752_22490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6752_22495	COG3005	denitrification pathway
K6752_22500	COG0243	molybdopterin cofactor binding
K6752_22520	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K6752_22525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K6752_22530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6752_22535	COG1116	anion transmembrane transporter activity
K6752_22540	COG0351	phosphomethylpyrimidine kinase
K6752_22545	COG0312	modulator of DNA gyrase
K6752_22550	COG0312	modulator of DNA gyrase
K6752_22615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6752_22625	COG0584	glycerophosphoryl diester phosphodiesterase
K6752_22630	COG0745	RESPONSE REGULATOR receiver
K6752_22650	COG0811	peptide transport
K6752_22655	COG0811	peptide transport
K6752_22660	COG0848	biopolymer transport protein
K6752_22700	COG0803	Belongs to the bacterial solute-binding protein 9 family
K6752_22705	COG1121	(ABC) transporter
K6752_22710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K6752_22725	COG1770	oligopeptidase
K6752_22730	COG2814	Major facilitator Superfamily
K6752_22735	COG0010	Belongs to the arginase family
K6752_22740	COG1166	arginine decarboxylase activity
K6752_22750	COG0189	ligase activity
K6752_22750	COG4067	protein conserved in archaea
K6752_22755	COG0189	ligase activity
K6752_22775	COG0583	DNA-binding transcription factor activity
K6752_22805	COG3706	GGDEF domain
K6752_22825	COG0579	oxidoreductase
K6752_22830	COG3179	chitinase
K6752_22845	COG1294	oxidase, subunit
K6752_22850	COG1271	oxidase subunit
K6752_22860	COG3033	Beta-eliminating lyase
K6752_22875	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6752_22890	COG3706	GGDEF domain
K6752_22905	COG3706	GGDEF domain
K6752_22910	COG0415	Belongs to the DNA photolyase family
K6752_22915	COG3046	protein related to deoxyribodipyrimidine photolyase
K6752_22930	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6752_22930	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6752_22935	COG1765	OsmC-like protein
K6752_22940	COG0110	maltose O-acetyltransferase activity
K6752_22975	COG1011	Hydrolase
K6752_22990	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K6752_22995	COG3338	carbonate dehydratase activity
K6752_23000	COG2067	long-chain fatty acid transport protein
K6752_23005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6752_23010	COG0577	efflux transmembrane transporter activity
K6752_23010	COG1136	(ABC) transporter
K6752_23025	COG1309	transcriptional regulator
K6752_23030	COG3240	lipase activity
K6752_23060	COG1609	Transcriptional regulator
K6752_23070	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K6752_23080	COG1840	ABC-type Fe3 transport system, periplasmic component
K6752_23085	COG3842	ATPase activity
K6752_23110	COG2990	Protein conserved in bacteria
K6752_23120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6752_23125	COG2866	Carboxypeptidase
K6752_23135	COG0583	DNA-binding transcription factor activity
K6752_23150	COG1760	l-serine dehydratase
K6752_23170	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K6752_23175	COG0741	lytic transglycosylase activity
K6752_23195	COG1815	bacterial-type flagellum-dependent cell motility
K6752_23200	COG1558	bacterial-type flagellum-dependent cell motility
K6752_23215	COG4787	bacterial-type flagellum-dependent cell motility
K6752_23220	COG4786	Flagellar basal body rod
K6752_23225	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K6752_23230	COG1706	bacterial-type flagellum-dependent cell motility
K6752_23240	COG1256	bacterial-type flagellum assembly
K6752_23240	COG4786	Flagellar basal body rod
K6752_23265	COG1304	FMN binding
K6752_23280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6752_23285	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K6752_23290	COG0459	protein refolding
K6752_23300	COG1280	lysine exporter protein (LysE YggA)
K6752_23320	COG1309	transcriptional regulator