locus-tag	class	description
K6750_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K6750_00010	COG0592	DNA-directed DNA polymerase activity
K6750_00020	COG0187	DNA topoisomerase II activity
K6750_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
K6750_00035	COG3977	Valine--pyruvate aminotransferase
K6750_00040	COG0366	Alpha amylase catalytic
K6750_00055	COG2119	membrane
K6750_00065	COG0425	Belongs to the sulfur carrier protein TusA family
K6750_00080	COG0604	alcohol dehydrogenase
K6750_00085	COG0183	Belongs to the thiolase family
K6750_00095	COG1739	Uncharacterized protein family UPF0029
K6750_00100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6750_00150	COG2132	Multicopper oxidase
K6750_00170	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K6750_00190	COG0006	proline dipeptidase activity
K6750_00190	COG0006	proline dipeptidase activity
K6750_00220	COG3220	belongs to the UPF0276 family
K6750_00230	COG0210	DNA helicase
K6750_00235	COG0405	Gamma-glutamyltransferase
K6750_00240	COG1280	lysine exporter protein (LysE YggA)
K6750_00250	COG2962	Rard protein
K6750_00255	COG0514	ATP-dependent DNA helicase (RecQ)
K6750_00265	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K6750_00275	COG0248	Ppx GppA phosphatase
K6750_00280	COG0513	Belongs to the DEAD box helicase family
K6750_00285	COG3118	belongs to the thioredoxin family
K6750_00300	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K6750_00305	COG0633	Ferredoxin
K6750_00345	COG3071	HemY protein
K6750_00350	COG2959	enzyme of heme biosynthesis
K6750_00355	COG1587	Uroporphyrinogen-III synthase
K6750_00360	COG0181	hydroxymethylbilane synthase activity
K6750_00365	COG3072	Adenylate cyclase
K6750_00370	COG1965	Belongs to the frataxin family
K6750_00380	COG0019	diaminopimelate decarboxylase activity
K6750_00395	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K6750_00400	COG1011	Hydrolase
K6750_00405	COG2199	diguanylate cyclase activity
K6750_00405	COG2200	EAL domain
K6750_00405	COG3287	FIST C domain
K6750_00410	COG3148	PFAM DTW domain containing protein
K6750_00425	COG0561	phosphatase activity
K6750_00430	COG2267	carboxylic ester hydrolase activity
K6750_00435	COG1280	lysine exporter protein (LysE YggA)
K6750_00440	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K6750_00445	COG0640	Transcriptional regulator
K6750_00450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K6750_00490	COG2095	MarC family integral membrane protein
K6750_00500	COG0742	ribosomal rna small subunit methyltransferase
K6750_00505	COG0552	protein localization to endoplasmic reticulum
K6750_00510	COG2884	Cell division ATP-binding protein ftsE
K6750_00515	COG2177	Part of the ABC transporter FtsEX involved in
K6750_00525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6750_00530	COG0705	Rhomboid family
K6750_00535	COG1580	Controls the rotational direction of flagella during chemotaxis
K6750_00540	COG3161	chorismate lyase activity
K6750_00545	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K6750_00550	COG2937	Belongs to the GPAT DAPAT family
K6750_00555	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K6750_00560	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K6750_00565	COG0534	Mate efflux family protein
K6750_00570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6750_00590	COG4206	TonB-dependent receptor
K6750_00665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6750_00675	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K6750_00680	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K6750_00680	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K6750_00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K6750_00715	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K6750_00720	COG0250	Participates in transcription elongation, termination and antitermination
K6750_00735	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K6750_00740	COG0222	ribosome binding
K6750_00745	COG0085	RNA polymerase activity
K6750_00750	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K6750_00755	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
K6750_00760	COG2816	NAD+ diphosphatase activity
K6750_00765	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K6750_00770	COG1573	uracil-dna glycosylase
K6750_00780	COG3068	Protein conserved in bacteria
K6750_00785	COG1253	flavin adenine dinucleotide binding
K6750_00800	COG0151	Belongs to the GarS family
K6750_00805	COG0138	bifunctional purine biosynthesis protein purh
K6750_00810	COG0789	Transcriptional regulator
K6750_00815	COG3710	Transcriptional regulator
K6750_00820	COG0531	amino acid
K6750_00825	COG1982	Orn Lys Arg decarboxylase major
K6750_00875	COG0488	(ABC) transporter
K6750_00885	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K6750_00890	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6750_00895	COG2264	protein methyltransferase activity
K6750_00900	COG0439	Biotin carboxylase
K6750_00905	COG0511	ligase activity, forming carbon-carbon bonds
K6750_00910	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K6750_00915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6750_00930	COG2814	Major facilitator Superfamily
K6750_00955	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6750_00965	COG3263	regulation of cellular component size
K6750_00975	COG4232	protein-disulfide reductase activity
K6750_00980	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K6750_00985	COG1027	Aspartate ammonia-lyase
K6750_00990	COG3030	protein affecting phage T7 exclusion by the F plasmid
K6750_00995	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K6750_01005	COG2205	protein histidine kinase activity
K6750_01010	COG0745	RESPONSE REGULATOR receiver
K6750_01015	COG3678	ATP-independent chaperone mediated protein folding
K6750_01025	COG0205	6-phosphofructokinase activity
K6750_01030	COG0534	Mate efflux family protein
K6750_01040	COG0459	protein refolding
K6750_01050	COG1285	pathogenesis
K6750_01055	COG1509	lysine 2,3-aminomutase activity
K6750_01070	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K6750_01075	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K6750_01080	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K6750_01085	COG1053	succinate dehydrogenase
K6750_01090	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K6750_01110	COG4942	peptidase
K6750_01115	COG1045	serine acetyltransferase
K6750_01120	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K6750_01125	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K6750_01130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6750_01135	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K6750_01145	COG0471	metal ion transport
K6750_01145	COG3273	potassium ion transport
K6750_01150	COG0688	phosphatidylethanolamine metabolic process
K6750_01155	COG1162	GTPase activity
K6750_01160	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K6750_01225	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K6750_01230	COG0802	atpase or kinase
K6750_01240	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K6750_01245	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K6750_01255	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K6750_01260	COG0330	HflC and HflK could
K6750_01265	COG0330	HflC and HflK could
K6750_01270	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
K6750_01275	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K6750_01280	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
K6750_01285	COG1017	nitric oxide dioxygenase activity
K6750_01285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K6750_01290	COG1959	2 iron, 2 sulfur cluster binding
K6750_01295	COG0557	exoribonuclease II activity
K6750_01300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6750_01305	COG0546	phosphoglycolate phosphatase activity
K6750_01310	COG0180	Tryptophanyl-tRNA synthetase
K6750_01325	COG0512	Glutamine amidotransferase of anthranilate synthase
K6750_01330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K6750_01350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6750_01355	COG3954	Phosphoribulokinase
K6750_01365	COG0429	hydrolase of the alpha beta-hydrolase fold
K6750_01375	COG0488	(ABC) transporter
K6750_01380	COG2249	NAD(P)H dehydrogenase (quinone) activity
K6750_01395	COG1047	Peptidyl-prolyl cis-trans
K6750_01400	COG1446	asparaginase
K6750_01415	COG0545	Peptidyl-prolyl cis-trans isomerase
K6750_01420	COG2964	Protein conserved in bacteria
K6750_01425	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
K6750_01430	COG2923	Belongs to the DsrF TusC family
K6750_01450	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K6750_01455	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K6750_01470	COG0281	malic enzyme
K6750_01475	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
K6750_01480	COG0626	cystathionine gamma-synthase activity
K6750_01485	COG0527	aspartate kinase activity
K6750_01485	COG0460	homoserine dehydrogenase
K6750_01490	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K6750_01500	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K6750_01510	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K6750_01520	COG0137	argininosuccinate synthase activity
K6750_01525	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K6750_01525	COG0165	Argininosuccinate lyase
K6750_01535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6750_01540	COG0678	peroxiredoxin activity
K6750_01540	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K6750_01550	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K6750_01580	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K6750_01585	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K6750_01595	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K6750_01600	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K6750_01605	COG0360	Binds together with S18 to 16S ribosomal RNA
K6750_01610	COG2965	DNA replication, synthesis of RNA primer
K6750_01635	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K6750_01640	COG0432	Pfam Uncharacterised protein family UPF0047
K6750_01645	COG0166	Belongs to the GPI family
K6750_01655	COG0735	belongs to the Fur family
K6750_01660	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6750_01680	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K6750_01685	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6750_01690	COG0175	sulfate reduction
K6750_01750	COG1410	methionine synthase
K6750_01750	COG0646	methionine synthase
K6750_01755	COG0527	aspartate kinase activity
K6750_01760	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K6750_01770	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K6750_01785	COG0629	single-stranded DNA binding
K6750_01790	COG2200	EAL domain
K6750_01790	COG2199	diguanylate cyclase activity
K6750_01810	COG1450	Type ii and iii secretion system protein
K6750_01815	COG3409	Peptidoglycan-binding domain 1 protein
K6750_01815	COG3267	Type II secretory pathway component ExeA
K6750_01825	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K6750_01830	COG1459	type II secretion system
K6750_01875	COG1077	Cell shape determining protein MreB Mrl
K6750_01880	COG1792	Involved in formation and maintenance of cell shape
K6750_01885	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K6750_01890	COG0424	maF-like protein
K6750_01900	COG3164	Protein of unknown function
K6750_01905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6750_01910	COG0312	modulator of DNA gyrase
K6750_01915	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K6750_01920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K6750_01930	COG0564	pseudouridine synthase activity
K6750_01935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6750_01940	COG3028	Belongs to the UPF0307 family
K6750_01945	COG0312	modulator of DNA gyrase
K6750_01950	COG2239	Acts as a magnesium transporter
K6750_01955	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6750_01960	COG1660	Displays ATPase and GTPase activities
K6750_01965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6750_01970	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K6750_01980	COG1137	ATPase activity
K6750_01985	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K6750_01995	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K6750_01995	COG0517	IMP dehydrogenase activity
K6750_02005	COG1127	ABC transporter
K6750_02010	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K6750_02015	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K6750_02020	COG2854	intermembrane phospholipid transfer
K6750_02030	COG5007	Belongs to the BolA IbaG family
K6750_02035	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K6750_02040	COG0204	Acyl-transferase
K6750_02045	COG0251	oxidation-reduction process
K6750_02050	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K6750_02055	COG0540	Belongs to the ATCase OTCase family
K6750_02085	COG0456	acetyltransferase
K6750_02095	COG0525	valine-tRNA ligase activity
K6750_02100	COG2927	DNA polymerase III (CHI subunit)
K6750_02105	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K6750_02110	COG0795	lipopolysaccharide-transporting ATPase activity
K6750_02115	COG0795	lipopolysaccharide-transporting ATPase activity
K6750_02130	COG1028	Short-chain dehydrogenase reductase Sdr
K6750_02145	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K6750_02150	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K6750_02155	COG1447	Phosphotransferase system cellobiose-specific component IIA
K6750_02160	COG1486	melibiose metabolic process
K6750_02165	COG3394	polysaccharide catabolic process
K6750_02170	COG1609	Transcriptional regulator
K6750_02175	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K6750_02250	COG0840	transmembrane signaling receptor activity
K6750_02295	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
K6750_02305	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K6750_02315	COG2066	Belongs to the glutaminase family
K6750_02320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K6750_02325	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K6750_02335	COG1872	DUF167
K6750_02340	COG0762	integral membrane protein
K6750_02345	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K6750_02350	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K6750_02365	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K6750_02370	COG1678	Uncharacterized ACR, COG1678
K6750_02375	COG0189	ligase activity
K6750_02380	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K6750_02385	COG2356	endonuclease I
K6750_02400	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K6750_02405	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K6750_02410	COG0583	DNA-binding transcription factor activity
K6750_02415	COG4771	TonB-dependent receptor
K6750_02430	COG0191	fructose-bisphosphate aldolase activity
K6750_02435	COG0668	transmembrane transport
K6750_02450	COG0583	DNA-binding transcription factor activity
K6750_02460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6750_02465	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K6750_02470	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K6750_02480	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K6750_02485	COG3079	Belongs to the UPF0149 family
K6750_02490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6750_02495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6750_02510	COG0354	folic acid binding
K6750_02515	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K6750_02525	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K6750_02530	COG1595	DNA-templated transcription, initiation
K6750_02545	COG3086	response to oxidative stress
K6750_02550	COG0481	GTPase activity
K6750_02555	COG0681	Belongs to the peptidase S26 family
K6750_02565	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K6750_02570	COG1381	Involved in DNA repair and RecF pathway recombination
K6750_02575	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K6750_02580	COG0736	holo-[acyl-carrier-protein] synthase activity
K6750_02590	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K6750_02595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K6750_02600	COG3956	TIGRFAM MazG family protein
K6750_02605	COG0504	CTP synthase activity
K6750_02610	COG0148	phosphopyruvate hydratase activity
K6750_02615	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K6750_02620	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K6750_02625	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K6750_02635	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K6750_02640	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K6750_02650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K6750_02655	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K6750_02660	COG1546	Belongs to the CinA family
K6750_02665	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K6750_02670	COG2137	regulation of response to DNA damage stimulus
K6750_02675	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K6750_02680	COG0527	aspartate kinase activity
K6750_02740	COG3630	sodium ion export across plasma membrane
K6750_02745	COG5016	pyruvate
K6750_02745	COG0511	ligase activity, forming carbon-carbon bonds
K6750_02750	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K6750_02760	COG1238	metal cluster binding
K6750_02765	COG0612	Peptidase, M16
K6750_02780	COG1854	S-ribosylhomocysteine lyase activity
K6750_02785	COG4536	flavin adenine dinucleotide binding
K6750_02790	COG4137	Cytochrome C assembly protein
K6750_02795	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K6750_02800	COG0228	four-way junction DNA binding
K6750_02805	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K6750_02820	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K6750_02825	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
K6750_02830	COG0237	dephospho-CoA kinase activity
K6750_02840	COG1459	type II secretion system
K6750_02845	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K6750_02850	COG4969	Belongs to the N-Me-Phe pilin family
K6750_02855	COG0157	Belongs to the NadC ModD family
K6750_02865	COG2186	Transcriptional regulator
K6750_02870	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K6750_02875	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6750_02880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6750_02895	COG0288	reversible hydration of carbon dioxide
K6750_02900	COG0659	secondary active sulfate transmembrane transporter activity
K6750_02905	COG1131	(ABC) transporter
K6750_02910	COG0842	Transport permease protein
K6750_02915	COG1560	Kdo2-lipid A biosynthetic process
K6750_02920	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K6750_02925	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K6750_02930	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K6750_02940	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K6750_02950	COG1489	DNA binding
K6750_02955	COG1643	Atp-dependent helicase
K6750_02960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6750_02965	COG1752	Esterase of the alpha-beta hydrolase superfamily
K6750_02970	COG1049	propionate catabolic process, 2-methylcitrate cycle
K6750_02975	COG3112	Uncharacterised protein family (UPF0231)
K6750_02985	COG0004	ammonium transporteR
K6750_02990	COG1840	ABC-type Fe3 transport system, periplasmic component
K6750_03000	COG3842	ATPase activity
K6750_03005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6750_03020	COG2971	BadF BadG BcrA BcrD
K6750_03030	COG4608	Belongs to the ABC transporter superfamily
K6750_03035	COG0444	Belongs to the ABC transporter superfamily
K6750_03040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6750_03050	COG0747	negative chemotaxis
K6750_03055	COG0784	Response regulator, receiver
K6750_03055	COG2205	protein histidine kinase activity
K6750_03065	COG0628	permease
K6750_03090	COG0739	heme binding
K6750_03095	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K6750_03105	COG2027	D-alanyl-D-alanine carboxypeptidase
K6750_03110	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6750_03115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6750_03120	COG1534	Rna-binding protein
K6750_03125	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K6750_03130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K6750_03135	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K6750_03140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6750_03145	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K6750_03160	COG0779	Required for maturation of 30S ribosomal subunits
K6750_03165	COG0195	Participates in both transcription termination and antitermination
K6750_03170	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K6750_03175	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K6750_03180	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K6750_03185	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K6750_03190	COG1185	polyribonucleotide nucleotidyltransferase activity
K6750_03205	COG0534	Mate efflux family protein
K6750_03210	COG0826	peptidase U32
K6750_03215	COG0826	peptidase U32
K6750_03225	COG3154	lipid carrier protein
K6750_03230	COG3153	acetyltransferase
K6750_03260	COG0084	hydrolase, TatD family'
K6750_03265	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6750_03270	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K6750_03275	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K6750_03280	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K6750_03285	COG0813	purine-nucleoside phosphorylase activity
K6750_03295	COG0560	Phosphoserine phosphatase
K6750_03305	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K6750_03310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K6750_03315	COG0583	DNA-binding transcription factor activity
K6750_03325	COG1022	Amp-dependent synthetase and ligase
K6750_03365	COG0583	DNA-binding transcription factor activity
K6750_03370	COG1609	Transcriptional regulator
K6750_03390	COG0598	Magnesium transport protein CorA
K6750_03395	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K6750_03400	COG1349	DNA-binding transcription factor activity
K6750_03405	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K6750_03410	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K6750_03415	COG2271	Major facilitator Superfamily
K6750_03420	COG0584	glycerophosphoryl diester phosphodiesterase
K6750_03425	COG2171	N-acyltransferase activity
K6750_03440	COG3141	response to X-ray
K6750_03460	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K6750_03465	COG1074	ATP-dependent DNA helicase activity
K6750_03470	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K6750_03490	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K6750_03490	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K6750_03500	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
K6750_03505	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K6750_03510	COG2166	iron-sulfur cluster assembly
K6750_03515	COG3706	GGDEF domain
K6750_03520	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K6750_03525	COG0693	protein deglycase activity
K6750_03530	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K6750_03535	COG3248	Nucleoside-binding outer membrane protein
K6750_03550	COG1595	DNA-templated transcription, initiation
K6750_03570	COG3056	Lipoprotein
K6750_03575	COG2813	Specifically methylates the guanine in position
K6750_03580	COG0271	Belongs to the BolA IbaG family
K6750_03585	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6750_03590	COG1805	sodium ion transport
K6750_03595	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6750_03600	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6750_03605	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6750_03610	COG2871	sodium ion transport
K6750_03615	COG1477	protein flavinylation
K6750_03635	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K6750_03640	COG0514	ATP-dependent DNA helicase (RecQ)
K6750_03645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6750_03660	COG0733	neurotransmitter:sodium symporter activity
K6750_03680	COG0442	prolyl-tRNA aminoacylation
K6750_03685	COG1720	tRNA m6t6A37 methyltransferase activity
K6750_03690	COG0254	rRNA binding
K6750_03700	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K6750_03725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6750_03730	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6750_03765	COG0564	pseudouridine synthase activity
K6750_03775	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K6750_03780	COG0024	Methionine aminopeptidase
K6750_03785	COG0052	Belongs to the universal ribosomal protein uS2 family
K6750_03790	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K6750_03795	COG0528	UMP kinase activity
K6750_03800	COG0233	cytoplasmic translational termination
K6750_03805	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K6750_03810	COG0575	Belongs to the CDS family
K6750_03815	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K6750_03820	COG0750	zinc metalloprotease
K6750_03830	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
K6750_03835	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6750_03845	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6750_03850	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6750_03860	COG0587	DNA-directed DNA polymerase activity
K6750_03865	COG0825	malonyl-CoA metabolic process
K6750_03880	COG0347	Belongs to the P(II) protein family
K6750_03885	COG3021	interspecies interaction between organisms
K6750_03895	COG0741	lytic transglycosylase activity
K6750_03895	COG1388	LysM domain
K6750_03900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6750_03905	COG2226	methyltransferase
K6750_03910	COG0328	RNA-DNA hybrid ribonuclease activity
K6750_03945	COG1960	acyl-CoA dehydrogenase activity
K6750_03950	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K6750_03955	COG0121	glutamine amidotransferase
K6750_03960	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K6750_03965	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K6750_03970	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K6750_03975	COG2233	PERMEase
K6750_04000	COG1393	Belongs to the ArsC family
K6750_04005	COG4783	chaperone-mediated protein folding
K6750_04020	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K6750_04030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6750_04035	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
K6750_04050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6750_04055	COG1393	Belongs to the ArsC family
K6750_04080	COG2837	iron assimilation
K6750_04085	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6750_04090	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6750_04095	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6750_04100	COG1334	flagellar protein FlaG
K6750_04105	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K6750_04115	COG1516	flagellar protein fliS
K6750_04135	COG1677	Flagellar hook-basal body complex protein FliE
K6750_04145	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K6750_04200	COG1987	bacterial-type flagellum assembly
K6750_04205	COG1684	flagellar biosynthetic protein fliR
K6750_04240	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
K6750_04245	COG0643	Histidine kinase
K6750_04245	COG0784	Response regulator, receiver
K6750_04245	COG2198	Histidine kinase
K6750_04250	COG2201	protein-glutamate methylesterase activity
K6750_04255	COG1192	Involved in chromosome partitioning
K6750_04265	COG0835	chemotaxis
K6750_04275	COG4133	protoheme IX ABC transporter activity
K6750_04280	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6750_04285	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6750_04290	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6750_04295	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K6750_04300	COG1138	Cytochrome C-type biogenesis protein
K6750_04305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6750_04315	COG3088	subunit of a heme lyase
K6750_04315	COG4235	cytochrome complex assembly
K6750_04330	COG2067	long-chain fatty acid transport protein
K6750_04335	COG2067	long-chain fatty acid transport protein
K6750_04350	COG0183	Belongs to the thiolase family
K6750_04355	COG1024	Enoyl-CoA hydratase
K6750_04355	COG1250	3-hydroxyacyl-CoA dehydrogenase
K6750_04370	COG2062	phosphohistidine phosphatase, SixA
K6750_04375	COG2840	Smr protein MutS2
K6750_04380	COG2890	protein-(glutamine-N5) methyltransferase activity
K6750_04385	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K6750_04390	COG2860	membrane
K6750_04395	COG3101	peptidyl-lysine hydroxylation
K6750_04405	COG0431	NADPH-dependent FMN reductase
K6750_04410	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K6750_04410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6750_04415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K6750_04420	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6750_04425	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K6750_04435	COG0101	tRNA pseudouridine synthase activity
K6750_04440	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K6750_04445	COG0285	dihydrofolate synthase activity
K6750_04450	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
K6750_04455	COG1286	toxin biosynthetic process
K6750_04460	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K6750_04465	COG0583	DNA-binding transcription factor activity
K6750_04470	COG0745	RESPONSE REGULATOR receiver
K6750_04475	COG2832	Protein of unknown function (DUF454)
K6750_04480	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K6750_04495	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K6750_04500	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K6750_04510	COG2261	transglycosylase associated protein
K6750_04515	COG2983	Belongs to the UPF0260 family
K6750_04520	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K6750_04615	COG4695	Portal protein
K6750_04665	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K6750_04745	COG0668	transmembrane transport
K6750_04750	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
K6750_04755	COG0346	lactoylglutathione lyase activity
K6750_04765	COG1785	Belongs to the alkaline phosphatase family
K6750_04780	COG2226	methyltransferase
K6750_04795	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K6750_04800	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6750_04810	COG3139	Protein of unknown function (DUF1315)
K6750_04815	COG0252	asparaginase activity
K6750_04820	COG0616	signal peptide processing
K6750_04825	COG1902	pentaerythritol trinitrate reductase activity
K6750_04825	COG0446	pyridine nucleotide-disulphide oxidoreductase
K6750_04835	COG0778	Nitroreductase
K6750_04840	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K6750_04855	COG0123	including yeast histone deacetylase and acetoin utilization protein
K6750_04870	COG3082	Protein of unknown function (DUF1414)
K6750_04875	COG3081	Nucleoid-associated protein
K6750_04890	COG1757	Na H antiporter
K6750_04895	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K6750_04900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6750_04905	COG2095	MarC family integral membrane protein
K6750_04910	COG1012	belongs to the aldehyde dehydrogenase family
K6750_04910	COG1454	alcohol dehydrogenase
K6750_04930	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K6750_04950	COG2056	Na+-H+ antiporter family
K6750_04955	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K6750_04960	COG2885	chlorophyll binding
K6750_04970	COG0346	lactoylglutathione lyase activity
K6750_04975	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K6750_04980	COG4660	Part of a membrane complex involved in electron transport
K6750_04985	COG4659	FMN binding
K6750_04990	COG4658	electron transport chain
K6750_04995	COG4656	Part of a membrane complex involved in electron transport
K6750_05000	COG2878	Part of a membrane complex involved in electron transport
K6750_05005	COG4657	Part of a membrane complex involved in electron transport
K6750_05010	COG1882	Formate acetyltransferase
K6750_05020	COG0556	nucleotide-excision repair
K6750_05025	COG2204	response regulator
K6750_05030	COG2198	Histidine kinase
K6750_05035	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K6750_05040	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K6750_05045	COG0521	Mo-molybdopterin cofactor biosynthetic process
K6750_05050	COG0315	cyclic pyranopterin monophosphate synthase activity
K6750_05055	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K6750_05060	COG0314	molybdopterin synthase activity
K6750_05070	COG0601	transmembrane transport
K6750_05075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6750_05080	COG0444	Belongs to the ABC transporter superfamily
K6750_05090	COG0435	Glutathione S-transferase
K6750_05100	COG0280	phosphate acetyltransferase
K6750_05100	COG0857	belongs to the CobB CobQ family
K6750_05105	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K6750_05110	COG3092	negative regulation of chromosome organization
K6750_05120	COG4120	Belongs to the binding-protein-dependent transport system permease family
K6750_05125	COG1122	ATPase activity
K6750_05130	COG0366	Alpha amylase catalytic
K6750_05135	COG3706	GGDEF domain
K6750_05140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6750_05145	COG3318	Belongs to the UPF0149 family
K6750_05145	COG3012	SEC-C Motif Domain Protein
K6750_05150	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K6750_05155	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K6750_05160	COG2186	Transcriptional regulator
K6750_05170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6750_05170	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6750_05180	COG0572	uridine kinase
K6750_05190	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
K6750_05195	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K6750_05200	COG0659	secondary active sulfate transmembrane transporter activity
K6750_05205	COG1530	ribonuclease E activity
K6750_05210	COG0564	pseudouridine synthase activity
K6750_05215	COG0424	maF-like protein
K6750_05220	COG1399	metal-binding, possibly nucleic acid-binding protein
K6750_05230	COG0416	fatty acid biosynthetic process
K6750_05235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6750_05265	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K6750_05270	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K6750_05275	COG0470	DNA polymerase III
K6750_05280	COG0084	hydrolase, TatD family'
K6750_05285	COG1263	PTS System
K6750_05285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6750_05300	COG0733	neurotransmitter:sodium symporter activity
K6750_05315	COG4667	esterase of the alpha-beta hydrolase superfamily
K6750_05320	COG0469	pyruvate kinase activity
K6750_05325	COG1940	carbohydrate kinase activity
K6750_05330	COG0835	chemotaxis
K6750_05330	COG0784	Response regulator, receiver
K6750_05335	COG0587	DNA-directed DNA polymerase activity
K6750_05350	COG1028	Short-chain dehydrogenase reductase Sdr
K6750_05355	COG0616	signal peptide processing
K6750_05360	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K6750_05365	COG0539	negative regulation of cytoplasmic translation
K6750_05375	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
K6750_05380	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K6750_05390	COG4166	transmembrane transport
K6750_05410	COG3008	intermembrane lipid transfer
K6750_05410	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K6750_05415	COG2995	paraquat-inducible protein a
K6750_05420	COG3258	Cytochrome c
K6750_05425	COG2863	cytochrome
K6750_05460	COG4232	protein-disulfide reductase activity
K6750_05465	COG3118	belongs to the thioredoxin family
K6750_05485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6750_05495	COG0577	efflux transmembrane transporter activity
K6750_05495	COG1136	(ABC) transporter
K6750_05505	COG1136	(ABC) transporter
K6750_05505	COG0577	efflux transmembrane transporter activity
K6750_05560	COG5002	protein histidine kinase activity
K6750_05560	COG3850	Histidine kinase
K6750_05565	COG0745	RESPONSE REGULATOR receiver
K6750_05570	COG0463	Glycosyl transferase, family 2
K6750_05575	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K6750_05595	COG1032	radical SAM domain protein
K6750_05600	COG5001	Diguanylate cyclase
K6750_05615	COG0583	DNA-binding transcription factor activity
K6750_05620	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K6750_05630	COG2350	Protein conserved in bacteria
K6750_05640	COG2917	probably involved in intracellular septation
K6750_05660	COG1301	dicarboxylic acid transport
K6750_05665	COG0318	PFAM AMP-dependent synthetase and ligase
K6750_05670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6750_05675	COG0159	tryptophan synthase activity
K6750_05685	COG0135	phosphoribosylanthranilate isomerase activity
K6750_05685	COG0134	indole-3-glycerol-phosphate synthase activity
K6750_05695	COG0512	Glutamine amidotransferase of anthranilate synthase
K6750_05700	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K6750_05710	COG0613	PHP domain protein
K6750_05715	COG0009	L-threonylcarbamoyladenylate synthase
K6750_05725	COG1187	pseudouridine synthase activity
K6750_05745	COG0417	DNA replication proofreading
K6750_05750	COG2197	response regulator
K6750_05755	COG0322	excinuclease ABC activity
K6750_05795	COG0019	diaminopimelate decarboxylase activity
K6750_05825	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K6750_05830	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K6750_05850	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
K6750_05860	COG0437	4 iron, 4 sulfur cluster binding
K6750_05865	COG3301	Polysulphide reductase, NrfD
K6750_05870	COG1138	Cytochrome C-type biogenesis protein
K6750_05875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6750_05880	COG3088	subunit of a heme lyase
K6750_05880	COG4235	cytochrome complex assembly
K6750_05890	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6750_05915	COG2989	Protein conserved in bacteria
K6750_05920	COG3108	Peptidase M15
K6750_05925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6750_05940	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K6750_05970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6750_05975	COG0840	transmembrane signaling receptor activity
K6750_05995	COG1448	Aminotransferase
K6750_06010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6750_06020	COG0017	Asparaginyl-tRNA synthetase
K6750_06025	COG0840	transmembrane signaling receptor activity
K6750_06030	COG0720	synthase
K6750_06040	COG2200	EAL domain
K6750_06045	COG1760	l-serine dehydratase
K6750_06050	COG0814	amino acid
K6750_06055	COG0494	nUDIX hydrolase
K6750_06065	COG0784	Response regulator, receiver
K6750_06065	COG2205	protein histidine kinase activity
K6750_06085	COG3106	COG3106 Predicted ATPase
K6750_06090	COG3768	UPF0283 membrane protein
K6750_06100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6750_06115	COG0653	protein targeting
K6750_06135	COG0582	viral genome integration into host DNA
K6750_06155	COG5532	Uncharacterized conserved protein (DUF2303)
K6750_06210	COG1802	Transcriptional regulator
K6750_06210	COG4626	Terminase
K6750_06230	COG1403	HNH endonuclease
K6750_06480	COG0582	viral genome integration into host DNA
K6750_06955	COG0110	maltose O-acetyltransferase activity
K6750_06965	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K6750_06985	COG5507	3-demethylubiquinone-9 3-methyltransferase
K6750_06990	COG1280	lysine exporter protein (LysE YggA)
K6750_06995	COG1280	lysine exporter protein (LysE YggA)
K6750_07005	COG0729	surface antigen
K6750_07010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6750_07015	COG2272	Belongs to the type-B carboxylesterase lipase family
K6750_07040	COG2985	domain, Protein
K6750_07050	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K6750_07065	COG0583	DNA-binding transcription factor activity
K6750_07080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6750_07095	COG3290	protein histidine kinase activity
K6750_07100	COG4565	transcriptional regulatory protein
K6750_07110	COG2207	Transcriptional regulator
K6750_07115	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K6750_07120	COG0363	glucosamine-6-phosphate deaminase activity
K6750_07125	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K6750_07145	COG3284	Transcriptional regulator
K6750_07150	COG1012	belongs to the aldehyde dehydrogenase family
K6750_07220	COG4669	(LipO)protein
K6750_07240	COG3177	Filamentation induced by cAMP protein fic
K6750_07270	COG2207	Transcriptional regulator
K6750_07275	COG4792	protein secretion
K6750_07280	COG4791	protein targeting
K6750_07285	COG4794	Type iii secretion
K6750_07290	COG4790	Type iii secretion
K6750_07360	COG0457	Tetratricopeptide repeat
K6750_07380	COG2358	TRAP transporter, solute receptor (TAXI family
K6750_07385	COG0730	response to heat
K6750_07420	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K6750_07425	COG0372	Belongs to the citrate synthase family
K6750_07435	COG2828	Protein conserved in bacteria
K6750_07460	COG0561	phosphatase activity
K6750_07465	COG0602	queuosine metabolic process
K6750_07470	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K6750_07485	COG0583	DNA-binding transcription factor activity
K6750_07490	COG0583	DNA-binding transcription factor activity
K6750_07505	COG0583	DNA-binding transcription factor activity
K6750_07520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6750_07525	COG0765	amino acid transport
K6750_07530	COG1126	abc transporter atp-binding protein
K6750_07535	COG1410	methionine synthase
K6750_07535	COG0646	methionine synthase
K6750_07550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6750_07555	COG1335	isochorismatase
K6750_07575	COG2814	Major facilitator Superfamily
K6750_07580	COG0583	DNA-binding transcription factor activity
K6750_07590	COG0583	DNA-binding transcription factor activity
K6750_07595	COG0656	L-ascorbic acid biosynthetic process
K6750_07605	COG1414	Transcriptional regulator
K6750_07610	COG2203	Gaf domain
K6750_07610	COG2199	diguanylate cyclase activity
K6750_07640	COG2885	chlorophyll binding
K6750_07670	COG0840	transmembrane signaling receptor activity
K6750_07675	COG1254	Belongs to the acylphosphatase family
K6750_07680	COG2920	part of a sulfur-relay system
K6750_07690	COG0670	Belongs to the BI1 family
K6750_07695	COG1126	abc transporter atp-binding protein
K6750_07700	COG0765	amino acid transport
K6750_07705	COG4597	amino acid ABC transporter
K6750_07710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6750_07720	COG1666	GTP binding
K6750_07725	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K6750_07750	COG3008	intermembrane lipid transfer
K6750_07755	COG2995	paraquat-inducible protein a
K6750_07760	COG1132	(ABC) transporter
K6750_07765	COG1956	GAF domain-containing protein
K6750_07770	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
K6750_07795	COG2902	Dehydrogenase
K6750_07805	COG0167	dihydroorotate dehydrogenase activity
K6750_07815	COG0116	Belongs to the methyltransferase superfamily
K6750_07815	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K6750_07825	COG0488	(ABC) transporter
K6750_07840	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K6750_07845	COG1067	ATP-dependent peptidase activity
K6750_07850	COG3120	sequence-specific DNA binding
K6750_07905	COG2205	protein histidine kinase activity
K6750_07905	COG0784	Response regulator, receiver
K6750_07920	COG3278	Belongs to the heme-copper respiratory oxidase family
K6750_07935	COG2010	Cytochrome c
K6750_07945	COG2217	Heavy metal translocating P-type atpase
K6750_07960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6750_07965	COG0589	response to stress
K6750_07990	COG3842	ATPase activity
K6750_08000	COG1177	transmembrane transport
K6750_08010	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K6750_08015	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K6750_08025	COG0004	ammonium transporteR
K6750_08055	COG4282	regulation of fungal-type cell wall biogenesis
K6750_08105	COG0437	4 iron, 4 sulfur cluster binding
K6750_08110	COG0243	molybdopterin cofactor binding
K6750_08110	COG3383	formate dehydrogenase (NAD+) activity
K6750_08140	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K6750_08145	COG0488	(ABC) transporter
K6750_08150	COG4191	Histidine kinase
K6750_08155	COG2204	response regulator
K6750_08170	COG3842	ATPase activity
K6750_08175	COG0746	molybdenum cofactor guanylyltransferase activity
K6750_08180	COG0303	'Molybdopterin
K6750_08190	COG1940	carbohydrate kinase activity
K6750_08195	COG3148	PFAM DTW domain containing protein
K6750_08230	COG0791	NLP P60 protein
K6750_08240	COG3706	GGDEF domain
K6750_08250	COG3001	Fructosamine kinase
K6750_08260	COG0307	riboflavin synthase, alpha
K6750_08265	COG0534	Mate efflux family protein
K6750_08275	COG1793	dna ligase
K6750_08305	COG2204	response regulator
K6750_08310	COG0438	transferase activity, transferring glycosyl groups
K6750_08315	COG0438	transferase activity, transferring glycosyl groups
K6750_08345	COG0438	transferase activity, transferring glycosyl groups
K6750_08350	COG1215	transferase activity, transferring glycosyl groups
K6750_08355	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6750_08365	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6750_08380	COG1643	Atp-dependent helicase
K6750_08385	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K6750_08430	COG0443	Heat shock 70 kDa protein
K6750_08435	COG0443	Heat shock 70 kDa protein
K6750_08460	COG0583	DNA-binding transcription factor activity
K6750_08475	COG1132	(ABC) transporter
K6750_08480	COG1132	(ABC) transporter
K6750_08490	COG4774	siderophore transport
K6750_08500	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6750_08505	COG1120	ATPase activity
K6750_08520	COG0814	amino acid
K6750_08530	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K6750_08540	COG0861	Integral membrane protein TerC family
K6750_08550	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K6750_08555	COG1328	CTP reductase activity
K6750_08570	COG3300	MHYT domain
K6750_08570	COG5001	Diguanylate cyclase
K6750_08585	COG0471	metal ion transport
K6750_08610	COG4702	Belongs to the UPF0303 family
K6750_08615	COG0673	inositol 2-dehydrogenase activity
K6750_08620	COG1349	DNA-binding transcription factor activity
K6750_08635	COG1538	Outer membrane efflux protein
K6750_08660	COG3119	arylsulfatase activity
K6750_08675	COG0641	radical SAM
K6750_08690	COG3119	arylsulfatase activity
K6750_08695	COG0527	aspartate kinase activity
K6750_08700	COG0662	Cupin 2, conserved barrel domain protein
K6750_08705	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K6750_08710	COG0456	acetyltransferase
K6750_08715	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6750_08735	COG4176	ABC-type proline glycine betaine transport system permease component
K6750_08740	COG2113	Glycine betaine
K6750_08745	COG1368	sulfuric ester hydrolase activity
K6750_08770	COG1115	amino acid carrier protein
K6750_08780	COG1280	lysine exporter protein (LysE YggA)
K6750_08785	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K6750_08790	COG1560	Kdo2-lipid A biosynthetic process
K6750_08805	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K6750_08810	COG3063	Type IV pilus biogenesis stability protein PilW
K6750_08850	COG2315	Protein conserved in bacteria
K6750_08855	COG1846	Transcriptional regulator
K6750_08865	COG2200	EAL domain
K6750_08870	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K6750_08875	COG1012	belongs to the aldehyde dehydrogenase family
K6750_08880	COG2957	Belongs to the agmatine deiminase family
K6750_08890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6750_08895	COG1012	belongs to the aldehyde dehydrogenase family
K6750_08900	COG1396	sequence-specific DNA binding
K6750_08900	COG1917	Cupin 2, conserved barrel domain protein
K6750_08905	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K6750_08910	COG0174	glutamine synthetase
K6750_08915	COG1757	Na H antiporter
K6750_08930	COG1742	UPF0060 membrane protein
K6750_08955	COG3755	Protein conserved in bacteria
K6750_09005	COG0625	glutathione transferase activity
K6750_09015	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K6750_09025	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6750_09035	COG0601	transmembrane transport
K6750_09040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6750_09060	COG3291	Pkd domain containing protein
K6750_09070	COG1177	transmembrane transport
K6750_09080	COG3842	ATPase activity
K6750_09085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6750_09090	COG2423	ornithine cyclodeaminase activity
K6750_09105	COG3938	Belongs to the proline racemase family
K6750_09135	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
K6750_09140	COG1451	nucleotide metabolic process
K6750_09150	COG0583	DNA-binding transcription factor activity
K6750_09170	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
K6750_09175	COG4139	cobalamin transport
K6750_09180	COG2988	succinylglutamate desuccinylase activity
K6750_09200	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K6750_09205	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K6750_09210	COG0702	epimerase
K6750_09215	COG1823	symporter activity
K6750_09220	COG2925	Exonuclease
K6750_09225	COG1380	Effector of murein hydrolase LrgA
K6750_09230	COG1346	cytolysis
K6750_09235	COG0295	cytidine deaminase activity
K6750_09245	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K6750_09250	COG0500	methyltransferase
K6750_09260	COG0776	regulation of translation
K6750_09270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6750_09270	COG0072	phenylalanine-tRNA ligase activity
K6750_09275	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K6750_09310	COG0393	Putative heavy-metal-binding
K6750_09320	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K6750_09330	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K6750_09345	COG2188	Transcriptional regulator
K6750_09350	COG1228	amidohydrolase
K6750_09355	COG0010	Belongs to the arginase family
K6750_09360	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K6750_09365	COG2986	histidine ammonia-lyase
K6750_09380	COG0247	lactate metabolic process
K6750_09380	COG0277	FAD linked oxidase domain protein
K6750_09495	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K6750_09515	COG1643	Atp-dependent helicase
K6750_09520	COG0281	malic enzyme
K6750_09525	COG2949	membrane
K6750_09530	COG0471	metal ion transport
K6750_09555	COG0492	ferredoxin-NADP+ reductase activity
K6750_09560	COG4988	ABC transporter
K6750_09565	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K6750_09575	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K6750_09585	COG4191	Histidine kinase
K6750_09585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6750_09600	COG3070	regulator of competence-specific genes
K6750_09610	COG2431	L-lysine efflux transmembrane transporter activity
K6750_09620	COG0076	glutamate decarboxylase activity
K6750_09625	COG1737	Transcriptional regulator
K6750_09635	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K6750_09640	COG3273	potassium ion transport
K6750_09640	COG2985	domain, Protein
K6750_09645	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K6750_09650	COG1960	acyl-CoA dehydrogenase activity
K6750_09660	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K6750_09680	COG0534	Mate efflux family protein
K6750_09685	COG0702	epimerase
K6750_09695	COG2814	Major facilitator Superfamily
K6750_09700	COG1187	pseudouridine synthase activity
K6750_09705	COG1061	Type III restriction enzyme res subunit
K6750_09725	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K6750_09745	COG3313	Fe-S protein
K6750_09755	COG4134	Bacterial extracellular solute-binding protein
K6750_09760	COG4135	transport system, permease component
K6750_09765	COG4136	ATPase activity
K6750_09770	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K6750_09785	COG1151	hydroxylamine reductase activity
K6750_09790	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K6750_09800	COG0564	pseudouridine synthase activity
K6750_09805	COG0733	neurotransmitter:sodium symporter activity
K6750_09815	COG0626	cystathionine gamma-synthase activity
K6750_09820	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
K6750_09825	COG5380	lipid catabolic process
K6750_09830	COG2818	Glycosylase
K6750_09850	COG1983	PspC domain protein
K6750_09860	COG1842	Phage shock protein A
K6750_09865	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K6750_09890	COG4172	Belongs to the ABC transporter superfamily
K6750_09900	COG1227	inorganic diphosphatase activity
K6750_09915	COG0243	molybdopterin cofactor binding
K6750_09920	COG3005	denitrification pathway
K6750_09925	COG4459	periplasmic nitrate reductase
K6750_09930	COG0390	transport system, permease component
K6750_09940	COG2116	formate transmembrane transporter activity
K6750_09965	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K6750_09970	COG1435	thymidine kinase activity
K6750_09975	COG0215	cysteine-tRNA ligase activity
K6750_09980	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K6750_09985	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6750_09990	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K6750_09995	COG3012	SEC-C Motif Domain Protein
K6750_10000	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K6750_10000	COG0140	phosphoribosyl-ATP diphosphatase activity
K6750_10010	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K6750_10015	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K6750_10020	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K6750_10020	COG0131	Imidazoleglycerol-phosphate dehydratase
K6750_10030	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K6750_10040	COG1757	Na H antiporter
K6750_10050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6750_10065	COG2915	High frequency lysogenization protein hflD homolog
K6750_10070	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K6750_10080	COG2268	Band 7 protein
K6750_10090	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K6750_10105	COG0300	oxidoreductase activity
K6750_10125	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K6750_10150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K6750_10170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K6750_10180	COG1674	ftsk spoiiie
K6750_10190	COG0686	Belongs to the AlaDH PNT family
K6750_10200	COG0583	DNA-binding transcription factor activity
K6750_10225	COG3568	Endonuclease Exonuclease Phosphatase
K6750_10250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6750_10255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6750_10275	COG1271	oxidase subunit
K6750_10280	COG1294	oxidase, subunit
K6750_10295	COG0784	Response regulator, receiver
K6750_10295	COG5002	protein histidine kinase activity
K6750_10305	COG0754	glutathionylspermidine amidase activity
K6750_10315	COG3766	membrane
K6750_10325	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K6750_10330	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
K6750_10335	COG2885	chlorophyll binding
K6750_10340	COG0823	Involved in the tonB-independent uptake of proteins
K6750_10355	COG0811	peptide transport
K6750_10360	COG0824	Thioesterase
K6750_10370	COG4890	Cyd operon protein YbgT
K6750_10375	COG1294	oxidase, subunit
K6750_10380	COG1271	oxidase subunit
K6750_10385	COG2255	four-way junction helicase activity
K6750_10390	COG0632	four-way junction helicase activity
K6750_10395	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K6750_10400	COG0217	transcriptional regulatory protein
K6750_10410	COG1801	Protein of unknown function DUF72
K6750_10420	COG0500	methyltransferase
K6750_10425	COG0189	ligase activity
K6750_10425	COG4067	protein conserved in archaea
K6750_10445	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K6750_10450	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
K6750_10455	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
K6750_10460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K6750_10465	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K6750_10470	COG0745	RESPONSE REGULATOR receiver
K6750_10475	COG3381	protein complex oligomerization
K6750_10480	COG1609	Transcriptional regulator
K6750_10485	COG3070	regulator of competence-specific genes
K6750_10505	COG0297	glycogen (starch) synthase activity
K6750_10510	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K6750_10515	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K6750_10535	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K6750_10540	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K6750_10545	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K6750_10550	COG0542	response to heat
K6750_10555	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K6750_10560	COG1278	Cold shock
K6750_10570	COG1187	pseudouridine synthase activity
K6750_10575	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K6750_10580	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6750_10585	COG1199	ATP-dependent helicase activity
K6750_10590	COG0730	response to heat
K6750_10595	COG3923	Primosomal replication protein n
K6750_10605	COG0708	Exodeoxyribonuclease III
K6750_10645	COG1882	Formate acetyltransferase
K6750_10655	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K6750_10665	COG3013	Belongs to the UPF0304 family
K6750_10670	COG2766	serine protein kinase
K6750_10675	COG2718	Belongs to the UPF0229 family
K6750_10680	COG2719	SpoVR family
K6750_10700	COG1132	(ABC) transporter
K6750_10710	COG2333	competence protein COMEC
K6750_10710	COG0658	competence protein
K6750_10720	COG4591	ABC-type transport system involved in lipoprotein release permease component
K6750_10725	COG1136	(ABC) transporter
K6750_10730	COG4591	ABC-type transport system involved in lipoprotein release permease component
K6750_10740	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K6750_10755	COG1252	NADH dehydrogenase
K6750_10760	COG3150	esterase
K6750_10785	COG0537	adenosine 5'-monophosphoramidase activity
K6750_10815	COG0517	IMP dehydrogenase activity
K6750_10815	COG0516	GMP reductase activity
K6750_10820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6750_10840	COG4771	TonB-dependent receptor
K6750_10845	COG0583	DNA-binding transcription factor activity
K6750_10855	COG0861	Integral membrane protein TerC family
K6750_10860	COG1028	Short-chain dehydrogenase reductase Sdr
K6750_10870	COG0633	Ferredoxin
K6750_10870	COG3217	Mosc domain protein beta barrel domain protein
K6750_10880	COG0583	DNA-binding transcription factor activity
K6750_10885	COG0596	Alpha beta hydrolase
K6750_10895	COG2814	Major facilitator Superfamily
K6750_10920	COG1278	Cold shock
K6750_10940	COG1278	Cold shock
K6750_11000	COG3126	Type III secretion system lipoprotein chaperone (YscW)
K6750_11005	COG1946	Acyl-CoA thioesterase
K6750_11015	COG1522	sequence-specific DNA binding
K6750_11020	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6750_11035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6750_11040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6750_11085	COG0477	Major facilitator Superfamily
K6750_11090	COG2855	membrane
K6750_11110	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K6750_11120	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K6750_11125	COG1169	isochorismate synthase
K6750_11130	COG0436	Aminotransferase
K6750_11135	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K6750_11140	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K6750_11155	COG1555	photosystem II stabilization
K6750_11160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6750_11165	COG0776	regulation of translation
K6750_11170	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K6750_11175	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K6750_11185	COG0544	peptidyl-prolyl cis-trans isomerase activity
K6750_11200	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K6750_11205	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K6750_11210	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K6750_11215	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K6750_11230	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6750_11235	COG0569	domain protein
K6750_11240	COG0513	Belongs to the DEAD box helicase family
K6750_11275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6750_11280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6750_11295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K6750_11300	COG1216	Glycosyl transferase, family 2
K6750_11305	COG2986	histidine ammonia-lyase
K6750_11330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K6750_11340	COG1028	Short-chain dehydrogenase reductase Sdr
K6750_11355	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K6750_11360	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6750_11370	COG2951	lytic endotransglycosylase activity
K6750_11375	COG3100	YcgL domain-containing protein
K6750_11380	COG0850	regulation of cytokinetic process
K6750_11385	COG2894	cell division
K6750_11390	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K6750_11395	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K6750_11400	COG0318	PFAM AMP-dependent synthetase and ligase
K6750_11405	COG2267	carboxylic ester hydrolase activity
K6750_11410	COG3065	identical protein binding
K6750_11420	COG1214	PFAM Peptidase M22, glycoprotease
K6750_11425	COG1199	ATP-dependent helicase activity
K6750_11430	COG0788	formyltetrahydrofolate deformylase activity
K6750_11435	COG3102	Protein conserved in bacteria
K6750_11440	COG0018	arginyl-trna synthetase
K6750_11465	COG1918	ferrous iron import across plasma membrane
K6750_11470	COG4977	sequence-specific DNA binding
K6750_11475	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
K6750_11480	COG1121	(ABC) transporter
K6750_11485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K6750_11495	COG0045	succinate-CoA ligase (ADP-forming) activity
K6750_11500	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6750_11505	COG0567	Dehydrogenase, E1 component
K6750_11510	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K6750_11515	COG1053	succinate dehydrogenase
K6750_11520	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K6750_11535	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K6750_11545	COG0033	Phosphoglucomutase
K6750_11550	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
K6750_11555	COG0596	Alpha beta hydrolase
K6750_11565	COG0716	FMN binding
K6750_11575	COG0735	belongs to the Fur family
K6750_11580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K6750_11585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6750_11585	COG1263	PTS System
K6750_11585	COG2190	(PTS) system
K6750_11590	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K6750_11595	COG1846	Transcriptional regulator
K6750_11595	COG1940	carbohydrate kinase activity
K6750_11600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K6750_11600	COG4651	solute:proton antiporter activity
K6750_11605	COG0367	asparagine synthase
K6750_11610	COG0250	Participates in transcription elongation, termination and antitermination
K6750_11615	COG3104	oligopeptide transport
K6750_11620	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K6750_11630	COG0326	Molecular chaperone. Has ATPase activity
K6750_11635	COG3710	Transcriptional regulator
K6750_11655	COG0622	Phosphoesterase
K6750_11680	COG1090	epimerase
K6750_11685	COG0300	oxidoreductase activity
K6750_11690	COG3118	belongs to the thioredoxin family
K6750_11695	COG0330	HflC and HflK could
K6750_11715	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K6750_11720	COG3115	cell septum assembly
K6750_11725	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
K6750_11730	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6750_11735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6750_11740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K6750_11745	COG2190	(PTS) system
K6750_11750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6750_11755	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6750_11760	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6750_11765	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6750_11775	COG1705	Flagellar rod assembly protein muramidase FlgJ
K6750_11775	COG3951	Flagellar rod assembly protein muramidase FlgJ
K6750_11780	COG1706	bacterial-type flagellum-dependent cell motility
K6750_11785	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K6750_11795	COG4787	bacterial-type flagellum-dependent cell motility
K6750_11800	COG1749	Flagellar hook protein flgE
K6750_11810	COG1558	bacterial-type flagellum-dependent cell motility
K6750_11815	COG1815	bacterial-type flagellum-dependent cell motility
K6750_11820	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K6750_11825	COG0784	Response regulator, receiver
K6750_11825	COG0835	chemotaxis
K6750_11880	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K6750_11890	COG2608	mercury ion transmembrane transporter activity
K6750_11890	COG2217	Heavy metal translocating P-type atpase
K6750_11935	COG1187	pseudouridine synthase activity
K6750_11940	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K6750_11945	COG0737	Belongs to the 5'-nucleotidase family
K6750_11950	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K6750_11955	COG2912	Transglutaminase-like superfamily
K6750_11960	COG3094	Invasion gene expression up-regulator, SirB
K6750_11965	COG2890	protein-(glutamine-N5) methyltransferase activity
K6750_11975	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K6750_11980	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K6750_11985	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K6750_11990	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K6750_11995	COG0193	aminoacyl-tRNA hydrolase activity
K6750_12000	COG0012	GTP binding
K6750_12105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6750_12110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K6750_12115	COG1702	phosphate starvation-inducible protein PhoH
K6750_12120	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K6750_12125	COG4535	Mg2 and Co2 transporter CorC
K6750_12130	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K6750_12135	COG2888	peptidyl-tyrosine sulfation
K6750_12140	COG0495	leucyl-tRNA aminoacylation
K6750_12145	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
K6750_12150	COG1466	dna polymerase III delta subunit
K6750_12155	COG0799	negative regulation of ribosome biogenesis
K6750_12160	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K6750_12165	COG0768	penicillin binding
K6750_12170	COG0772	Belongs to the SEDS family
K6750_12175	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K6750_12180	COG1686	Belongs to the peptidase S11 family
K6750_12190	COG0321	lipoyl(octanoyl) transferase activity
K6750_12195	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K6750_12200	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K6750_12205	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6750_12220	COG0366	Alpha amylase catalytic
K6750_12225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6750_12225	COG1263	PTS System
K6750_12235	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K6750_12240	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K6750_12245	COG2011	ABC-type metal ion transport system permease component
K6750_12250	COG1464	Belongs to the NlpA lipoprotein family
K6750_12255	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
K6750_12265	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K6750_12265	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K6750_12280	COG1611	Belongs to the LOG family
K6750_12285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6750_12295	COG2363	Small membrane protein
K6750_12305	COG0583	DNA-binding transcription factor activity
K6750_12310	COG0301	tRNA thio-modification
K6750_12310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6750_12320	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K6750_12325	COG1722	exodeoxyribonuclease VII activity
K6750_12330	COG0142	geranyltranstransferase activity
K6750_12335	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K6750_12340	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K6750_12345	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K6750_12355	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K6750_12370	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6750_12370	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6750_12375	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K6750_12380	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K6750_12385	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K6750_12395	COG1073	alpha beta
K6750_12400	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K6750_12405	COG2252	PERMEase
K6750_12410	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6750_12440	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K6750_12440	COG0047	phosphoribosylformylglycinamidine synthase activity
K6750_12445	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K6750_12455	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K6750_12485	COG0484	heat shock protein binding
K6750_12495	COG1301	dicarboxylic acid transport
K6750_12500	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K6750_12505	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K6750_12515	COG0497	DNA recombination
K6750_12525	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6750_12530	COG2914	Belongs to the UPF0125 (RnfH) family
K6750_12535	COG2867	negative regulation of translational initiation
K6750_12540	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K6750_12565	COG0583	DNA-binding transcription factor activity
K6750_12570	COG3153	acetyltransferase
K6750_12570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6750_12590	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K6750_12595	COG2873	o-acetylhomoserine
K6750_12610	COG1115	amino acid carrier protein
K6750_12615	COG1584	GPR1 FUN34 yaaH family protein
K6750_12625	COG1757	Na H antiporter
K6750_12635	COG0516	GMP reductase activity
K6750_12635	COG0517	IMP dehydrogenase activity
K6750_12655	COG1160	GTP binding
K6750_12660	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6750_12665	COG2976	Protein conserved in bacteria
K6750_12670	COG0124	histidyl-tRNA synthetase
K6750_12675	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K6750_12690	COG0105	UTP biosynthetic process
K6750_12700	COG2975	iron-sulfur cluster assembly
K6750_12705	COG0633	Ferredoxin
K6750_12710	COG0443	Heat shock 70 kDa protein
K6750_12725	COG0822	iron-sulfur transferase activity
K6750_12730	COG1104	cysteine desulfurase activity
K6750_12740	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
K6750_12745	COG0483	inositol monophosphate 1-phosphatase activity
K6750_12760	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6750_12765	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6750_12770	COG1862	Preprotein translocase
K6750_12780	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K6750_12790	COG0517	IMP dehydrogenase activity
K6750_12800	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K6750_12805	COG0583	DNA-binding transcription factor activity
K6750_12810	COG0450	alkyl hydroperoxide reductase
K6750_12815	COG3142	Participates in the control of copper homeostasis
K6750_12825	COG0704	Plays a role in the regulation of phosphate uptake
K6750_12830	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K6750_12835	COG0581	inorganic phosphate transmembrane transporter activity
K6750_12840	COG0573	inorganic phosphate transmembrane transporter activity
K6750_12845	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K6750_12850	COG0248	Ppx GppA phosphatase
K6750_12860	COG5002	protein histidine kinase activity
K6750_12865	COG0745	RESPONSE REGULATOR receiver
K6750_12870	COG2974	May be involved in recombination
K6750_12875	COG0826	peptidase U32
K6750_12880	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K6750_12935	COG0542	response to heat
K6750_12945	COG0564	pseudouridine synthase activity
K6750_12950	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6750_12960	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K6750_12965	COG0077	Prephenate dehydratase
K6750_12965	COG1605	Chorismate mutase
K6750_12970	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
K6750_12975	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
K6750_12985	COG0488	(ABC) transporter
K6750_12995	COG0739	heme binding
K6750_13000	COG0287	Prephenate dehydrogenase
K6750_13000	COG1605	Chorismate mutase
K6750_13005	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K6750_13010	COG1472	Belongs to the glycosyl hydrolase 3 family
K6750_13015	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K6750_13035	COG1966	Carbon starvation protein
K6750_13040	COG3275	phosphorelay sensor kinase activity
K6750_13045	COG3279	Response regulator of the LytR AlgR family
K6750_13055	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K6750_13060	COG1047	Peptidyl-prolyl cis-trans
K6750_13075	COG0196	riboflavin kinase activity
K6750_13080	COG0728	peptidoglycan biosynthetic process
K6750_13085	COG0268	Binds directly to 16S ribosomal RNA
K6750_13090	COG0640	Transcriptional regulator
K6750_13095	COG0583	DNA-binding transcription factor activity
K6750_13100	COG1283	sodium-dependent phosphate transmembrane transporter activity
K6750_13110	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K6750_13115	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K6750_13120	COG0730	response to heat
K6750_13145	COG0667	Aldo Keto reductase
K6750_13160	COG2204	response regulator
K6750_13175	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K6750_13180	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K6750_13185	COG4974	Belongs to the 'phage' integrase family
K6750_13190	COG0716	FMN binding
K6750_13200	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K6750_13205	COG0513	Belongs to the DEAD box helicase family
K6750_13210	COG3022	response to hydroperoxide
K6750_13215	COG1115	amino acid carrier protein
K6750_13230	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K6750_13235	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K6750_13240	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
K6750_13245	COG0431	NADPH-dependent FMN reductase
K6750_13250	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K6750_13255	COG0083	homoserine kinase activity
K6750_13275	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K6750_13285	COG0745	RESPONSE REGULATOR receiver
K6750_13295	COG2198	Histidine kinase
K6750_13295	COG5002	protein histidine kinase activity
K6750_13295	COG0784	Response regulator, receiver
K6750_13300	COG2203	Gaf domain
K6750_13300	COG3706	GGDEF domain
K6750_13300	COG4251	negative regulation of phosphorylation
K6750_13300	COG5001	Diguanylate cyclase
K6750_13305	COG1242	4 iron, 4 sulfur cluster binding
K6750_13310	COG0067	glutamate synthase
K6750_13310	COG0069	glutamate synthase activity
K6750_13310	COG0070	glutamate synthase
K6750_13320	COG0067	glutamate synthase
K6750_13320	COG0069	glutamate synthase activity
K6750_13320	COG0070	glutamate synthase
K6750_13325	COG0493	'glutamate synthase
K6750_13335	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K6750_13350	COG2860	membrane
K6750_13355	COG0583	DNA-binding transcription factor activity
K6750_13360	COG0730	response to heat
K6750_13375	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K6750_13380	COG0505	Belongs to the CarA family
K6750_13390	COG0494	nUDIX hydrolase
K6750_13395	COG0653	protein targeting
K6750_13405	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K6750_13410	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K6750_13415	COG0849	cell division
K6750_13420	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K6750_13435	COG0772	Belongs to the SEDS family
K6750_13440	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K6750_13445	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6750_13450	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K6750_13455	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K6750_13460	COG0768	penicillin binding
K6750_13465	COG3116	cell division
K6750_13480	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K6750_13495	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K6750_13500	COG2823	Periplasmic or secreted lipoprotein
K6750_13505	COG2969	positive regulation of protein catabolic process
K6750_13510	COG0625	glutathione transferase activity
K6750_13515	COG2857	Cytochrome c1
K6750_13520	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K6750_13525	COG0723	plastoquinol--plastocyanin reductase activity
K6750_13530	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K6750_13540	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K6750_13545	COG3105	Protein conserved in bacteria
K6750_13555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6750_13560	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K6750_13570	COG3150	esterase
K6750_13580	COG3151	Protein conserved in bacteria
K6750_13585	COG0494	nUDIX hydrolase
K6750_13590	COG1538	Outer membrane efflux protein
K6750_13595	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K6750_13595	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K6750_13600	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K6750_13615	COG3025	triphosphatase activity
K6750_13620	COG1392	Phosphate transport regulator
K6750_13625	COG0306	phosphate transporter
K6750_13630	COG4991	sh3 domain protein
K6750_13635	COG0405	Gamma-glutamyltransferase
K6750_13645	COG3267	Type II secretory pathway component ExeA
K6750_13645	COG3409	Peptidoglycan-binding domain 1 protein
K6750_13655	COG1968	undecaprenyl-diphosphatase activity
K6750_13660	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K6750_13665	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K6750_13670	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K6750_13675	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K6750_13680	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K6750_13685	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K6750_13690	COG1610	YqeY-like protein
K6750_13695	COG0358	DNA primase activity
K6750_13820	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6750_13820	COG2213	PTS system mannitol-specific
K6750_13830	COG3722	fumarate hydratase activity
K6750_13845	COG1461	Dihydroxyacetone kinase
K6750_13850	COG2376	Dihydroxyacetone kinase
K6750_13860	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K6750_13865	COG1349	DNA-binding transcription factor activity
K6750_13870	COG0469	pyruvate kinase activity
K6750_13885	COG0440	acetolactate synthase activity
K6750_13890	COG0028	Belongs to the TPP enzyme family
K6750_13895	COG1022	Amp-dependent synthetase and ligase
K6750_13900	COG0583	DNA-binding transcription factor activity
K6750_13920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K6750_13925	COG0473	3-isopropylmalate dehydrogenase activity
K6750_13945	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K6750_13950	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K6750_13955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6750_13960	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K6750_13965	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K6750_13970	COG2967	ApaG domain
K6750_13975	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K6750_13990	COG2966	Psort location CytoplasmicMembrane, score
K6750_13995	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K6750_14005	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K6750_14010	COG0142	geranyltranstransferase activity
K6750_14030	COG2358	TRAP transporter, solute receptor (TAXI family
K6750_14045	COG1902	pentaerythritol trinitrate reductase activity
K6750_14050	COG0583	DNA-binding transcription factor activity
K6750_14055	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K6750_14060	COG1178	ABC-type Fe3 transport system permease component
K6750_14070	COG0163	prenyltransferase activity
K6750_14075	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K6750_14080	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K6750_14085	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K6750_14095	COG2105	PFAM AIG2 family protein
K6750_14100	COG2911	Protein conserved in bacteria
K6750_14105	COG0729	surface antigen
K6750_14110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6750_14120	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K6750_14135	COG4181	ATPase activity
K6750_14155	COG0529	Catalyzes the synthesis of activated sulfate
K6750_14160	COG0471	metal ion transport
K6750_14160	COG3273	potassium ion transport
K6750_14165	COG2895	sulfate adenylyltransferase (ATP) activity
K6750_14170	COG0175	sulfate reduction
K6750_14175	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K6750_14175	COG1648	precorrin-2 dehydrogenase activity
K6750_14190	COG0513	Belongs to the DEAD box helicase family
K6750_14195	COG2153	protein acetylation
K6750_14205	COG0545	Peptidyl-prolyl cis-trans isomerase
K6750_14215	COG0203	ribosomal protein L17
K6750_14220	COG0202	RNA polymerase activity
K6750_14230	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K6750_14235	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K6750_14240	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K6750_14245	COG0201	protein transport
K6750_14250	COG0200	Binds to the 23S rRNA
K6750_14255	COG1841	ribosomal large subunit assembly
K6750_14270	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K6750_14275	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K6750_14285	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K6750_14290	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K6750_14300	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K6750_14305	COG0255	Belongs to the universal ribosomal protein uL29 family
K6750_14315	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K6750_14320	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K6750_14325	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K6750_14330	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K6750_14340	COG0088	Forms part of the polypeptide exit tunnel
K6750_14345	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K6750_14355	COG0254	rRNA binding
K6750_14360	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K6750_14365	COG1609	Transcriptional regulator
K6750_14375	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K6750_14380	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K6750_14385	COG1575	Belongs to the MenA family. Type 1 subfamily
K6750_14390	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K6750_14400	COG1494	fructose-1,6-bisphosphatase
K6750_14430	COG0149	triose-phosphate isomerase activity
K6750_14455	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6750_14485	COG0438	transferase activity, transferring glycosyl groups
K6750_14495	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K6750_14530	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6750_14540	COG1560	Kdo2-lipid A biosynthetic process
K6750_14550	COG0859	PFAM glycosyl transferase family 9
K6750_14555	COG1519	Transferase
K6750_14570	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K6750_14575	COG1028	Short-chain dehydrogenase reductase Sdr
K6750_14585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6750_14615	COG3642	lipopolysaccharide core region biosynthetic process
K6750_14620	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K6750_14625	COG0859	PFAM glycosyl transferase family 9
K6750_14630	COG0463	Glycosyl transferase, family 2
K6750_14645	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K6750_14670	COG2003	Belongs to the UPF0758 family
K6750_14680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K6750_14685	COG1309	transcriptional regulator
K6750_14690	COG1560	Kdo2-lipid A biosynthetic process
K6750_14695	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K6750_14700	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K6750_14705	COG1561	YicC-like family, N-terminal region
K6750_14715	COG4608	Belongs to the ABC transporter superfamily
K6750_14720	COG0444	Belongs to the ABC transporter superfamily
K6750_14725	COG0747	negative chemotaxis
K6750_14730	COG4239	(ABC) transporter, permease
K6750_14735	COG4174	ABC transporter (Permease)
K6750_14755	COG0811	peptide transport
K6750_14760	COG0848	biopolymer transport protein
K6750_14775	COG0194	GDP metabolic process
K6750_14780	COG1758	RNA polymerase activity
K6750_14785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K6750_14790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6750_14795	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K6750_14800	COG2233	PERMEase
K6750_14820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6750_14830	COG2183	response to ionizing radiation
K6750_14845	COG1040	competence protein
K6750_14855	COG0494	nUDIX hydrolase
K6750_14860	COG1218	3'(2'),5'-bisphosphate nucleotidase
K6750_14870	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K6750_14875	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K6750_14880	COG3156	type II secretion system protein K
K6750_14885	COG4795	General secretion pathway protein
K6750_14890	COG2165	general secretion pathway protein
K6750_14895	COG2165	general secretion pathway protein
K6750_14900	COG2165	general secretion pathway protein
K6750_14905	COG1459	type II secretion system
K6750_14910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K6750_14920	COG3031	protein transport across the cell outer membrane
K6750_14925	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K6750_14930	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K6750_14935	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K6750_14945	COG0456	acetyltransferase
K6750_14950	COG1490	D-aminoacyl-tRNA deacylase activity
K6750_14955	COG1295	ribonuclease BN
K6750_14965	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K6750_14970	COG1217	gtp-binding protein TYPA
K6750_14975	COG0174	glutamine synthetase
K6750_14985	COG3852	Histidine kinase
K6750_14990	COG2204	response regulator
K6750_15000	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K6750_15030	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K6750_15035	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6750_15035	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6750_15040	COG0456	acetyltransferase
K6750_15050	COG0084	hydrolase, TatD family'
K6750_15060	COG0805	protein transport
K6750_15065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K6750_15075	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K6750_15080	COG3165	ubiquinone biosynthetic process from chorismate
K6750_15085	COG2226	methyltransferase
K6750_15090	COG1322	Protein conserved in bacteria
K6750_15105	COG0628	permease
K6750_15135	COG1597	lipid kinase activity
K6750_15165	COG2081	HI0933 family
K6750_15175	COG1528	Iron-storage protein
K6750_15180	COG0589	response to stress
K6750_15195	COG0742	ribosomal rna small subunit methyltransferase
K6750_15200	COG5002	protein histidine kinase activity
K6750_15200	COG5001	Diguanylate cyclase
K6750_15205	COG1522	sequence-specific DNA binding
K6750_15215	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K6750_15220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6750_15225	COG0583	DNA-binding transcription factor activity
K6750_15230	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K6750_15235	COG0800	Aldolase
K6750_15240	COG2610	gluconate transmembrane transporter activity
K6750_15245	COG3265	gluconokinase activity
K6750_15250	COG0129	dihydroxy-acid dehydratase activity
K6750_15265	COG0583	DNA-binding transcription factor activity
K6750_15270	COG1609	Transcriptional regulator
K6750_15280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6750_15285	COG0601	transmembrane transport
K6750_15290	COG4166	transmembrane transport
K6750_15345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6750_15350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6750_15355	COG2960	long-chain fatty acid transporting porin activity
K6750_15360	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K6750_15365	COG0583	DNA-binding transcription factor activity
K6750_15400	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K6750_15420	COG0009	L-threonylcarbamoyladenylate synthase
K6750_15425	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K6750_15430	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K6750_15435	COG0551	DNA topoisomerase type I activity
K6750_15440	COG2922	Belongs to the Smg family
K6750_15445	COG0758	DNA mediated transformation
K6750_15455	COG0242	peptide deformylase activity
K6750_15460	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K6750_15465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K6750_15465	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K6750_15470	COG0569	domain protein
K6750_15475	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6750_15485	COG1272	protein, Hemolysin III
K6750_15490	COG4326	sporulation control protein
K6750_15500	COG3084	Protein conserved in bacteria
K6750_15510	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K6750_15515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K6750_15520	COG0204	Acyl-transferase
K6750_15530	COG0606	chelatase, subunit chli
K6750_15540	COG3978	acetolactate synthase activity
K6750_15545	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6750_15550	COG0129	dihydroxy-acid dehydratase activity
K6750_15560	COG0583	DNA-binding transcription factor activity
K6750_15565	COG2814	Major facilitator Superfamily
K6750_15575	COG0765	amino acid transport
K6750_15585	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K6750_15590	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K6750_15595	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K6750_15600	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K6750_15605	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K6750_15610	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K6750_15620	COG0356	it plays a direct role in the translocation of protons across the membrane
K6750_15625	COG3312	ion transport
K6750_15630	COG1475	DNA binding
K6750_15635	COG1192	Involved in chromosome partitioning
K6750_15640	COG0357	Ribosomal RNA small subunit methyltransferase G
K6750_15645	COG0445	tRNA wobble uridine modification
K6750_15650	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K6750_15660	COG0706	membrane insertase activity
K6750_15670	COG0594	ribonuclease P activity
K6750_15680	COG1126	abc transporter atp-binding protein
K6750_15695	COG0840	transmembrane signaling receptor activity
K6750_15715	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6750_15730	COG2197	response regulator
K6750_15735	COG3850	Histidine kinase
K6750_15740	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K6750_15750	COG0243	molybdopterin cofactor binding
K6750_15760	COG3005	denitrification pathway
K6750_15770	COG3243	poly(R)-hydroxyalkanoic acid synthase
K6750_15780	COG0183	Belongs to the thiolase family
K6750_15790	COG1280	lysine exporter protein (LysE YggA)
K6750_15800	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6750_15805	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6750_15855	COG1846	Transcriptional regulator
K6750_15860	COG0784	Response regulator, receiver
K6750_15860	COG2205	protein histidine kinase activity
K6750_15865	COG1879	ABC-type sugar transport system periplasmic component
K6750_15870	COG2827	Endonuclease containing a URI domain
K6750_15875	COG3132	Protein of unknown function, DUF480
K6750_15895	COG5002	protein histidine kinase activity
K6750_15895	COG2205	protein histidine kinase activity
K6750_15895	COG0784	Response regulator, receiver
K6750_15915	COG0583	DNA-binding transcription factor activity
K6750_15925	COG0531	amino acid
K6750_15940	COG2205	protein histidine kinase activity
K6750_15945	COG0745	RESPONSE REGULATOR receiver
K6750_15970	COG1566	PFAM secretion protein HlyD family protein
K6750_15975	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K6750_15980	COG2239	Acts as a magnesium transporter
K6750_15985	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K6750_15990	COG0402	S-adenosylhomocysteine deaminase activity
K6750_15995	COG1418	mRNA catabolic process
K6750_16005	COG2814	Major facilitator Superfamily
K6750_16015	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6750_16035	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K6750_16050	COG0745	RESPONSE REGULATOR receiver
K6750_16055	COG2205	protein histidine kinase activity
K6750_16065	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K6750_16070	COG2194	sulfuric ester hydrolase activity
K6750_16090	COG4667	esterase of the alpha-beta hydrolase superfamily
K6750_16095	COG1741	Belongs to the pirin family
K6750_16100	COG1278	Cold shock
K6750_16115	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K6750_16120	COG0678	peroxiredoxin activity
K6750_16120	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K6750_16130	COG1686	Belongs to the peptidase S11 family
K6750_16135	COG0625	glutathione transferase activity
K6750_16140	COG1621	beta-fructofuranosidase activity
K6750_16145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6750_16150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6750_16150	COG1263	PTS System
K6750_16175	COG1028	Short-chain dehydrogenase reductase Sdr
K6750_16190	COG3746	phosphate-selective porin O and P
K6750_16205	COG0300	oxidoreductase activity
K6750_16210	COG0583	DNA-binding transcription factor activity
K6750_16215	COG2207	Transcriptional regulator
K6750_16215	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6750_16220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6750_16240	COG0513	Belongs to the DEAD box helicase family
K6750_16250	COG0583	DNA-binding transcription factor activity
K6750_16265	COG1902	pentaerythritol trinitrate reductase activity
K6750_16270	COG1063	alcohol dehydrogenase
K6750_16280	COG1028	Short-chain dehydrogenase reductase Sdr
K6750_16290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6750_16295	COG0006	proline dipeptidase activity
K6750_16300	COG3608	succinylglutamate desuccinylase aspartoacylase
K6750_16305	COG1522	sequence-specific DNA binding
K6750_16310	COG1012	belongs to the aldehyde dehydrogenase family
K6750_16315	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K6750_16320	COG3122	Protein conserved in bacteria
K6750_16335	COG0583	DNA-binding transcription factor activity
K6750_16340	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K6750_16345	COG0252	asparaginase activity
K6750_16350	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K6750_16365	COG2197	response regulator
K6750_16370	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K6750_16395	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6750_16425	COG3842	ATPase activity
K6750_16445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6750_16475	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6750_16510	COG0583	DNA-binding transcription factor activity
K6750_16520	COG4948	Mandelate Racemase Muconate Lactonizing
K6750_16550	COG1342	Belongs to the UPF0251 family
K6750_16555	COG4176	ABC-type proline glycine betaine transport system permease component
K6750_16560	COG3448	diguanylate cyclase activity
K6750_16560	COG4175	Glycine betaine
K6750_16565	COG3015	lipoprotein NlpE involved in copper resistance
K6750_16570	COG3713	MltA-interacting MipA family protein
K6750_16585	COG0583	DNA-binding transcription factor activity
K6750_16610	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K6750_16620	COG1335	isochorismatase
K6750_16635	COG1349	DNA-binding transcription factor activity
K6750_16640	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6750_16640	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6750_16645	COG2070	2-Nitropropane dioxygenase
K6750_16650	COG0531	amino acid
K6750_16655	COG4302	ethanolamine ammonia-lyase activity
K6750_16660	COG4303	Ethanolamine ammonia lyase large subunit
K6750_16670	COG1309	transcriptional regulator
K6750_16690	COG1280	lysine exporter protein (LysE YggA)
K6750_16700	COG0459	protein refolding
K6750_16705	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K6750_16710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6750_16725	COG1304	FMN binding
K6750_16750	COG4786	Flagellar basal body rod
K6750_16750	COG1256	bacterial-type flagellum assembly
K6750_16760	COG1706	bacterial-type flagellum-dependent cell motility
K6750_16765	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K6750_16770	COG4786	Flagellar basal body rod
K6750_16775	COG4787	bacterial-type flagellum-dependent cell motility
K6750_16790	COG1558	bacterial-type flagellum-dependent cell motility
K6750_16795	COG1815	bacterial-type flagellum-dependent cell motility
K6750_16815	COG1388	LysM domain
K6750_16815	COG0741	lytic transglycosylase activity
K6750_16820	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K6750_16840	COG1760	l-serine dehydratase
K6750_16855	COG0583	DNA-binding transcription factor activity
K6750_16865	COG2866	Carboxypeptidase
K6750_16870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6750_16880	COG2990	Protein conserved in bacteria
K6750_16905	COG3842	ATPase activity
K6750_16910	COG1840	ABC-type Fe3 transport system, periplasmic component
K6750_16920	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K6750_16930	COG1609	Transcriptional regulator
K6750_16960	COG3240	lipase activity
K6750_16965	COG1309	transcriptional regulator
K6750_16980	COG0577	efflux transmembrane transporter activity
K6750_16980	COG1136	(ABC) transporter
K6750_16985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6750_16990	COG2067	long-chain fatty acid transport protein
K6750_17015	COG1011	Hydrolase
K6750_17045	COG0110	maltose O-acetyltransferase activity
K6750_17050	COG1765	OsmC-like protein
K6750_17055	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6750_17055	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6750_17070	COG3046	protein related to deoxyribodipyrimidine photolyase
K6750_17075	COG0415	Belongs to the DNA photolyase family
K6750_17085	COG3706	GGDEF domain
K6750_17100	COG3706	GGDEF domain
K6750_17115	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6750_17130	COG3033	Beta-eliminating lyase
K6750_17140	COG1271	oxidase subunit
K6750_17145	COG1294	oxidase, subunit
K6750_17160	COG3179	chitinase
K6750_17165	COG0579	oxidoreductase
K6750_17185	COG3706	GGDEF domain
K6750_17195	COG4191	Histidine kinase
K6750_17215	COG0583	DNA-binding transcription factor activity
K6750_17235	COG0189	ligase activity
K6750_17240	COG0189	ligase activity
K6750_17240	COG4067	protein conserved in archaea
K6750_17250	COG1166	arginine decarboxylase activity
K6750_17260	COG2814	Major facilitator Superfamily
K6750_17265	COG1770	oligopeptidase
K6750_17280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K6750_17285	COG1121	(ABC) transporter
K6750_17290	COG0803	Belongs to the bacterial solute-binding protein 9 family
K6750_17335	COG0848	biopolymer transport protein
K6750_17340	COG0811	peptide transport
K6750_17345	COG0811	peptide transport
K6750_17365	COG0745	RESPONSE REGULATOR receiver
K6750_17370	COG0584	glycerophosphoryl diester phosphodiesterase
K6750_17380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6750_17445	COG0312	modulator of DNA gyrase
K6750_17450	COG0312	modulator of DNA gyrase
K6750_17455	COG0351	phosphomethylpyrimidine kinase
K6750_17460	COG1116	anion transmembrane transporter activity
K6750_17465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6750_17470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K6750_17475	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K6750_17495	COG0243	molybdopterin cofactor binding
K6750_17500	COG3005	denitrification pathway
K6750_17505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6750_17510	COG1028	Short-chain dehydrogenase reductase Sdr
K6750_17525	COG0456	acetyltransferase
K6750_17545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6750_17550	COG1929	Belongs to the glycerate kinase type-1 family
K6750_17555	COG2610	gluconate transmembrane transporter activity
K6750_17560	COG3835	regulator
K6750_17620	COG3047	cAMP biosynthetic process
K6750_17625	COG1357	PFAM Pentapeptide repeats (8 copies)
K6750_17655	COG2375	cellular response to nickel ion
K6750_17660	COG0583	DNA-binding transcription factor activity
K6750_17665	COG2162	N-hydroxyarylamine O-acetyltransferase activity
K6750_17670	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K6750_17685	COG2199	diguanylate cyclase activity
K6750_17695	COG0561	phosphatase activity
K6750_17700	COG0583	DNA-binding transcription factor activity
K6750_17715	COG0564	pseudouridine synthase activity
K6750_17720	COG0534	Mate efflux family protein
K6750_17735	COG3123	guanosine phosphorylase activity
K6750_17750	COG0596	Alpha beta hydrolase
K6750_17775	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6750_17785	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K6750_17790	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K6750_17790	COG2169	Transcriptional regulator
K6750_17800	COG2259	Doxx family
K6750_17805	COG1741	Belongs to the pirin family
K6750_17825	COG0363	glucosamine-6-phosphate deaminase activity
K6750_17835	COG0786	glutamate:sodium symporter activity
K6750_17840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6750_17845	COG1131	(ABC) transporter
K6750_17855	COG0786	glutamate:sodium symporter activity
K6750_17875	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K6750_17885	COG3279	Response regulator of the LytR AlgR family
K6750_17890	COG3275	phosphorelay sensor kinase activity
K6750_17920	COG0772	Belongs to the SEDS family
K6750_17945	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6750_17945	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
K6750_17955	COG0444	Belongs to the ABC transporter superfamily
K6750_17960	COG4608	Belongs to the ABC transporter superfamily
K6750_17985	COG1444	tRNA N-acetyltransferase activity
K6750_18005	COG3340	Belongs to the peptidase S51 family
K6750_18010	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6750_18015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6750_18015	COG1263	PTS System
K6750_18020	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K6750_18035	COG4166	transmembrane transport
K6750_18080	COG0259	pyridoxamine-phosphate oxidase activity
K6750_18105	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6750_18145	COG1132	(ABC) transporter
K6750_18155	COG0513	Belongs to the DEAD box helicase family
K6750_18160	COG2258	MOSC domain
K6750_18210	COG3634	alkyl hydroperoxide reductase activity
K6750_18220	COG1846	Transcriptional regulator
K6750_18225	COG1764	response to oxidative stress
K6750_18270	COG0577	efflux transmembrane transporter activity
K6750_18275	COG1136	(ABC) transporter
K6750_18285	COG0826	peptidase U32
K6750_18310	COG1653	transport
K6750_18315	COG0019	diaminopimelate decarboxylase activity
K6750_18320	COG4264	IucA IucC family
K6750_18345	COG4772	TonB-dependent receptor
K6750_18350	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K6750_18355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6750_18360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6750_18365	COG1120	ATPase activity
K6750_18370	COG0840	transmembrane signaling receptor activity
K6750_18375	COG0612	Peptidase, M16
K6750_18385	COG0739	heme binding
K6750_18400	COG2814	Major facilitator Superfamily
K6750_18410	COG1609	Transcriptional regulator
K6750_18415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6750_18430	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K6750_18430	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K6750_18440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K6750_18445	COG1609	Transcriptional regulator
K6750_18455	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K6750_18495	COG1760	l-serine dehydratase
K6750_18505	COG4580	involved in the transport of maltose and maltodextrins
K6750_18525	COG2356	endonuclease I
K6750_18545	COG1982	Orn Lys Arg decarboxylase major
K6750_18550	COG0531	amino acid
K6750_18560	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K6750_18565	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
K6750_18570	COG1162	GTPase activity
K6750_18575	COG1263	PTS System
K6750_18575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6750_18580	COG1999	signal sequence binding
K6750_18595	COG2909	trisaccharide binding
K6750_18600	COG0058	SHG alpha-glucan phosphorylase activity
K6750_18605	COG1640	4-alpha-glucanotransferase
K6750_18610	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K6750_18615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6750_18620	COG0366	Alpha amylase catalytic
K6750_18635	COG3366	ferrous iron transmembrane transporter activity
K6750_18640	COG0700	Nucleoside recognition
K6750_18645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6750_18650	COG3339	Conserved Protein
K6750_18665	COG1301	dicarboxylic acid transport
K6750_18675	COG0583	DNA-binding transcription factor activity
K6750_18690	COG0489	protein tyrosine kinase activity
K6750_18690	COG3206	protein involved in exopolysaccharide biosynthesis
K6750_18710	COG2095	MarC family integral membrane protein
K6750_18715	COG4667	esterase of the alpha-beta hydrolase superfamily
K6750_18720	COG3397	chitin binding
K6750_18725	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K6750_18730	COG0415	Belongs to the DNA photolyase family
K6750_18740	COG1054	Belongs to the UPF0176 family
K6750_18750	COG1686	Belongs to the peptidase S11 family
K6750_18775	COG0583	DNA-binding transcription factor activity
K6750_18780	COG4628	conserved protein (DUF2132)
K6750_18800	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K6750_18805	COG0628	permease
K6750_18845	COG2814	Major facilitator Superfamily
K6750_18855	COG0454	-acetyltransferase
K6750_18865	COG0745	RESPONSE REGULATOR receiver
K6750_18870	COG2205	protein histidine kinase activity
K6750_18885	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K6750_18890	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K6750_18895	COG1882	Formate acetyltransferase
K6750_18925	COG1360	Flagellar Motor Protein
K6750_18930	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K6750_18935	COG1191	sigma factor activity
K6750_18940	COG1580	Controls the rotational direction of flagella during chemotaxis
K6750_18955	COG1516	flagellar protein fliS
K6750_18960	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K6750_18970	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6750_18985	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K6750_18995	COG1987	bacterial-type flagellum assembly
K6750_19035	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K6750_19095	COG0346	lactoylglutathione lyase activity
K6750_19120	COG0745	RESPONSE REGULATOR receiver
K6750_19145	COG3300	MHYT domain
K6750_19145	COG5001	Diguanylate cyclase
K6750_19150	COG0156	8-amino-7-oxononanoate synthase activity
K6750_19155	COG1063	alcohol dehydrogenase
K6750_19190	COG0668	transmembrane transport
K6750_19200	COG1304	FMN binding
K6750_19205	COG1620	l-lactate permease
K6750_19210	COG0583	DNA-binding transcription factor activity
K6750_19215	COG1505	serine-type exopeptidase activity
K6750_19220	COG4172	Belongs to the ABC transporter superfamily
K6750_19230	COG1067	ATP-dependent peptidase activity
K6750_19240	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6750_19260	COG1247	-acetyltransferase
K6750_19265	COG0437	4 iron, 4 sulfur cluster binding
K6750_19270	COG0348	domain, Protein
K6750_19290	COG1122	ATPase activity
K6750_19295	COG4720	Psort location CytoplasmicMembrane, score
K6750_19300	COG1566	PFAM secretion protein HlyD family protein
K6750_19325	COG0813	purine-nucleoside phosphorylase activity
K6750_19330	COG3272	Protein of unknown function (DUF1722)
K6750_19335	COG0789	Transcriptional regulator
K6750_19340	COG0415	Belongs to the DNA photolyase family
K6750_19345	COG1376	ErfK ybiS ycfS ynhG family protein
K6750_19345	COG1388	LysM domain
K6750_19355	COG0513	Belongs to the DEAD box helicase family
K6750_19360	COG1770	oligopeptidase
K6750_19365	COG4771	TonB-dependent receptor
K6750_19395	COG0573	inorganic phosphate transmembrane transporter activity
K6750_19400	COG0581	inorganic phosphate transmembrane transporter activity
K6750_19405	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K6750_19420	COG2304	oxidoreductase activity
K6750_19440	COG0714	Associated with various cellular activities
K6750_19455	COG2197	response regulator
K6750_19490	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K6750_19495	COG1120	ATPase activity
K6750_19500	COG4774	siderophore transport
K6750_19505	COG1132	(ABC) transporter
K6750_19510	COG2205	protein histidine kinase activity
K6750_19510	COG2205	protein histidine kinase activity
K6750_19520	COG0569	domain protein
K6750_19525	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6750_19530	COG0583	DNA-binding transcription factor activity
K6750_19545	COG1012	belongs to the aldehyde dehydrogenase family
K6750_19550	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6750_19555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6750_19565	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
K6750_19570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6750_19600	COG2084	Dehydrogenase
K6750_19605	COG0753	catalase activity
K6750_19615	COG2130	NADP-dependent
K6750_19620	COG1309	transcriptional regulator
K6750_19625	COG3097	Belongs to the UPF0267 family
K6750_19680	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6750_19685	COG3842	ATPase activity
K6750_19695	COG1175	transmembrane transport
K6750_19700	COG3833	ABC-type maltose transport systems, permease component
K6750_19730	COG2354	Protein conserved in bacteria
K6750_19735	COG0418	dihydroorotase activity
K6750_19740	COG0401	homolog of Blt101
K6750_19745	COG3217	Mosc domain protein beta barrel domain protein
K6750_19745	COG0633	Ferredoxin
K6750_19745	COG3217	Mosc domain protein beta barrel domain protein
K6750_19745	COG0633	Ferredoxin
K6750_19755	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K6750_19795	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K6750_19800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6750_19810	COG0848	biopolymer transport protein
K6750_19815	COG0811	peptide transport
K6750_19820	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K6750_19830	COG3721	Heme iron utilization protein
K6750_19835	COG0748	coenzyme F420 binding
K6750_19845	COG0835	chemotaxis
K6750_19845	COG0784	Response regulator, receiver
K6750_19850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6750_19855	COG0534	Mate efflux family protein
K6750_19860	COG0444	Belongs to the ABC transporter superfamily
K6750_19865	COG4608	Belongs to the ABC transporter superfamily
K6750_19870	COG0747	negative chemotaxis
K6750_19880	COG1349	DNA-binding transcription factor activity
K6750_19885	COG2084	Dehydrogenase
K6750_19890	COG3395	kinase activity
K6750_19895	COG0235	Class ii aldolase
K6750_19900	COG3622	Belongs to the hyi family
K6750_19905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6750_19910	COG2610	gluconate transmembrane transporter activity
K6750_19935	COG0583	DNA-binding transcription factor activity
K6750_19940	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K6750_19950	COG4934	collagen metabolic process
K6750_19960	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K6750_19965	COG0789	Transcriptional regulator
K6750_19970	COG0366	Alpha amylase catalytic
K6750_19990	COG2249	NAD(P)H dehydrogenase (quinone) activity
K6750_19995	COG0589	response to stress
K6750_20000	COG0488	(ABC) transporter
K6750_20005	COG1505	serine-type exopeptidase activity
K6750_20015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6750_20025	COG2067	long-chain fatty acid transport protein
K6750_20035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6750_20060	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6750_20080	COG3383	formate dehydrogenase (NAD+) activity
K6750_20090	COG0842	Transport permease protein
K6750_20095	COG1131	(ABC) transporter
K6750_20110	COG1881	PFAM PEBP family protein
K6750_20120	COG0798	PFAM Bile acid sodium symporter
K6750_20135	COG1733	regulation of RNA biosynthetic process
K6750_20160	COG4989	oxidoreductase activity
K6750_20185	COG0814	amino acid
K6750_20200	COG3314	Sporulation integral membrane protein YlbJ
K6750_20220	COG0739	heme binding
K6750_20225	COG5001	Diguanylate cyclase
K6750_20230	COG0583	DNA-binding transcription factor activity
K6750_20235	COG2814	Major facilitator Superfamily
K6750_20250	COG0697	spore germination
K6750_20255	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6750_20265	COG0179	Fumarylacetoacetate (FAA) hydrolase
K6750_20285	COG1280	lysine exporter protein (LysE YggA)
K6750_20295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6750_20300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K6750_20305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K6750_20310	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K6750_20315	COG1845	cytochrome c oxidase, subunit III
K6750_20335	COG1612	heme a metabolic process
K6750_20340	COG0109	protoheme IX farnesyltransferase activity
K6750_20345	COG0545	Peptidyl-prolyl cis-trans isomerase
K6750_20375	COG1278	Cold shock
K6750_20380	COG3036	rescue of stalled ribosome
K6750_20385	COG2199	diguanylate cyclase activity
K6750_20400	COG1132	(ABC) transporter
K6750_20410	COG1538	Outer membrane efflux protein
K6750_20415	COG0784	Response regulator, receiver
K6750_20415	COG2205	protein histidine kinase activity
K6750_20440	COG0840	transmembrane signaling receptor activity
K6750_20445	COG0783	Belongs to the Dps family
K6750_20455	COG2133	pyrroloquinoline quinone binding
K6750_20460	COG1454	alcohol dehydrogenase
K6750_20465	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
K6750_20490	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K6750_20495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6750_20500	COG3186	Phenylalanine-4-hydroxylase
K6750_20525	COG3530	Putative quorum-sensing-regulated virulence factor
K6750_20540	COG2814	Major facilitator Superfamily
K6750_20545	COG0513	Belongs to the DEAD box helicase family
K6750_20550	COG4628	conserved protein (DUF2132)
K6750_20560	COG0133	tryptophan synthase activity
K6750_20565	COG1278	Cold shock
K6750_20575	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
K6750_20585	COG0523	cobalamin synthesis protein
K6750_20590	COG0513	Belongs to the DEAD box helicase family
K6750_20610	COG2200	EAL domain
K6750_20615	COG1119	ATPase activity
K6750_20620	COG0840	transmembrane signaling receptor activity
K6750_20650	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
K6750_20655	COG0513	Belongs to the DEAD box helicase family
K6750_20665	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K6750_20675	COG1073	alpha beta
K6750_20680	COG1073	alpha beta
K6750_20695	COG0730	response to heat
K6750_20710	COG0735	belongs to the Fur family
K6750_20715	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K6750_20725	COG0523	cobalamin synthesis protein
K6750_20730	COG2988	succinylglutamate desuccinylase activity
K6750_20735	COG0739	heme binding
K6750_20740	COG0523	cobalamin synthesis protein
K6750_20755	COG2095	MarC family integral membrane protein
K6750_20780	COG1024	Enoyl-CoA hydratase
K6750_20785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K6750_20790	COG1960	acyl-CoA dehydrogenase activity
K6750_20800	COG0183	Belongs to the thiolase family
K6750_20815	COG1024	Enoyl-CoA hydratase
K6750_20820	COG1024	Enoyl-CoA hydratase
K6750_20830	COG1028	Short-chain dehydrogenase reductase Sdr
K6750_20835	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K6750_20840	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K6750_20845	COG1845	cytochrome c oxidase, subunit III
K6750_20850	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K6750_20855	COG0109	protoheme IX farnesyltransferase activity
K6750_20860	COG0446	pyridine nucleotide-disulphide oxidoreductase
K6750_20860	COG1902	pentaerythritol trinitrate reductase activity
K6750_20875	COG1012	belongs to the aldehyde dehydrogenase family
K6750_20885	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6750_20915	COG1126	abc transporter atp-binding protein
K6750_20920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6750_20925	COG4215	(ABC) transporter
K6750_20930	COG4160	amino acid transport
K6750_21000	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6750_21005	COG2176	DNA-directed DNA polymerase activity
K6750_21010	COG0517	IMP dehydrogenase activity
K6750_21015	COG2186	Transcriptional regulator
K6750_21020	COG2186	Transcriptional regulator
K6750_21065	COG1917	Cupin 2, conserved barrel domain protein
K6750_21070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6750_21075	COG0800	Aldolase
K6750_21085	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K6750_21090	COG1028	Short-chain dehydrogenase reductase Sdr
K6750_21095	COG2847	Copper chaperone PCu(A)C
K6750_21155	COG0814	amino acid
K6750_21165	COG0243	molybdopterin cofactor binding
K6750_21170	COG1648	precorrin-2 dehydrogenase activity
K6750_21170	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K6750_21190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K6750_21190	COG1116	anion transmembrane transporter activity
K6750_21195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6750_21200	COG1116	anion transmembrane transporter activity
K6750_21205	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6750_21205	COG2146	nitrite reductase [NAD(P)H] activity
K6750_21255	COG0515	serine threonine protein kinase
K6750_21255	COG2815	serine threonine protein kinase
K6750_21290	COG0631	protein serine/threonine phosphatase activity
K6750_21360	COG0420	3'-5' exonuclease activity
K6750_21365	COG0419	ATPase involved in DNA repair
K6750_21375	COG3040	lipid binding
K6750_21385	COG1288	antiporter activity
K6750_21395	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
K6750_21410	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K6750_21425	COG0583	DNA-binding transcription factor activity
K6750_21430	COG0277	FAD linked oxidase domain protein
K6750_21445	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K6750_21495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K6750_21515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6750_21520	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6750_21530	COG2116	formate transmembrane transporter activity
K6750_21550	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K6750_21585	COG3118	belongs to the thioredoxin family
K6750_21590	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6750_21615	COG2271	Major facilitator Superfamily
K6750_21620	COG3851	Histidine kinase
K6750_21625	COG2197	response regulator
K6750_21635	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K6750_21640	COG0583	DNA-binding transcription factor activity
K6750_21645	COG0243	molybdopterin cofactor binding
K6750_21660	COG0384	phenazine biosynthesis protein PhzF
K6750_21665	COG1794	racemase activity, acting on amino acids and derivatives
K6750_21670	COG0446	pyridine nucleotide-disulphide oxidoreductase
K6750_21675	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K6750_21730	COG3706	GGDEF domain
K6750_21760	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K6750_21920	COG1328	CTP reductase activity
K6750_21925	COG0602	queuosine metabolic process
K6750_21930	COG0534	Mate efflux family protein
K6750_21935	COG2207	Transcriptional regulator
K6750_21945	COG4067	protein conserved in archaea
K6750_21945	COG0189	ligase activity
K6750_21955	COG3111	PFAM Bacterial OB fold (BOF) protein
K6750_21965	COG0725	ABC transporter, periplasmic molybdate-binding protein
K6750_21970	COG4149	molybdate abc transporter
K6750_21975	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K6750_21985	COG5001	Diguanylate cyclase
K6750_21985	COG2203	Gaf domain
K6750_21985	COG3706	GGDEF domain
K6750_21985	COG4251	negative regulation of phosphorylation
K6750_22005	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K6750_22010	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K6750_22035	COG3140	Belongs to the UPF0181 family
K6750_22165	COG1192	Involved in chromosome partitioning
K6750_22175	COG0023	Translation Initiation Factor
K6750_22185	COG1181	Belongs to the D-alanine--D-alanine ligase family
K6750_22195	COG1042	CoA-binding domain protein
K6750_22195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6750_22195	COG0045	succinate-CoA ligase (ADP-forming) activity
K6750_22200	COG0583	DNA-binding transcription factor activity
K6750_22215	COG3447	MASE1 domain protein
K6750_22215	COG5001	Diguanylate cyclase
K6750_22215	COG5002	protein histidine kinase activity
K6750_22220	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K6750_22225	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K6750_22230	COG1984	allophanate hydrolase subunit 2
K6750_22240	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K6750_22245	COG4181	ATPase activity
K6750_22255	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K6750_22260	COG5001	Diguanylate cyclase
K6750_22260	COG3300	MHYT domain
K6750_22295	COG4533	DNA binding
K6750_22305	COG2050	protein possibly involved in aromatic compounds catabolism
K6750_22320	COG2067	long-chain fatty acid transport protein
K6750_22325	COG2267	carboxylic ester hydrolase activity
K6750_22355	COG0737	Belongs to the 5'-nucleotidase family
K6750_22360	COG3593	DNA synthesis involved in DNA repair
K6750_22370	COG0583	DNA-binding transcription factor activity
K6750_22375	COG2116	formate transmembrane transporter activity
K6750_22380	COG2353	YceI-like domain
K6750_22385	COG3038	cytochrome b561
K6750_22405	COG0513	Belongs to the DEAD box helicase family
K6750_22410	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
K6750_22420	COG0840	transmembrane signaling receptor activity
K6750_22425	COG0546	phosphoglycolate phosphatase activity
K6750_22440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6750_22445	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K6750_22450	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K6750_22460	COG2207	Transcriptional regulator
K6750_22465	COG1979	alcohol dehydrogenase
K6750_22475	COG1126	abc transporter atp-binding protein
K6750_22480	COG0765	amino acid transport
K6750_22485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6750_22490	COG0765	amino acid transport
K6750_22495	COG2203	Gaf domain
K6750_22495	COG2199	diguanylate cyclase activity
K6750_22495	COG2200	EAL domain
K6750_22510	COG1609	Transcriptional regulator
K6750_22515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6750_22515	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6750_22520	COG1105	Belongs to the carbohydrate kinase PfkB family
K6750_22525	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K6750_22525	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K6750_22525	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
K6750_22555	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K6750_22565	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K6750_22570	COG0509	glycine decarboxylation via glycine cleavage system
K6750_22580	COG0346	lactoylglutathione lyase activity
K6750_22585	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K6750_22590	COG0583	DNA-binding transcription factor activity
K6750_22595	COG0697	spore germination
K6750_22600	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K6750_22640	COG2176	DNA-directed DNA polymerase activity
K6750_22685	COG0242	peptide deformylase activity
K6750_22720	COG2239	Acts as a magnesium transporter
K6750_22740	COG0346	lactoylglutathione lyase activity
K6750_22745	COG1902	pentaerythritol trinitrate reductase activity
K6750_22755	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K6750_22755	COG2755	lipolytic protein G-D-S-L family
K6750_22765	COG5642	Protein of unknown function (DUF2384)
K6750_22770	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K6750_22805	COG2076	Multidrug Resistance protein
K6750_22825	COG2962	Rard protein
K6750_22840	COG0784	Response regulator, receiver
K6750_22840	COG0835	chemotaxis
K6750_22845	COG2197	response regulator
K6750_22855	COG3706	GGDEF domain
K6750_22860	COG2197	response regulator
K6750_22865	COG5001	Diguanylate cyclase
K6750_22865	COG3300	MHYT domain
K6750_22870	COG2205	protein histidine kinase activity
K6750_22870	COG0784	Response regulator, receiver
K6750_22875	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K6750_22895	COG1214	PFAM Peptidase M22, glycoprotease
K6750_22895	COG0456	acetyltransferase
K6750_22905	COG3069	C4-dicarboxylate transmembrane transporter activity
K6750_22930	COG3111	PFAM Bacterial OB fold (BOF) protein
K6750_22935	COG1597	lipid kinase activity
K6750_22940	COG0583	DNA-binding transcription factor activity
K6750_22945	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6750_22975	COG0714	Associated with various cellular activities
K6750_22980	COG0641	radical SAM
K6750_22985	COG3119	arylsulfatase activity
K6750_22995	COG3119	arylsulfatase activity
K6750_23000	COG0745	RESPONSE REGULATOR receiver
K6750_23015	COG2205	protein histidine kinase activity
K6750_23015	COG2198	Histidine kinase
K6750_23015	COG0784	Response regulator, receiver
K6750_23020	COG1879	ABC-type sugar transport system periplasmic component
K6750_23025	COG1803	Methylglyoxal synthase
K6750_23030	COG0210	DNA helicase
K6750_23035	COG1289	transmembrane transporter activity
K6750_23065	COG4771	TonB-dependent receptor
K6750_23065	COG1629	transport
K6750_23075	COG0789	Transcriptional regulator
K6750_23080	COG4604	ABC transporter, ATP-binding protein
K6750_23085	COG4605	iron ion homeostasis
K6750_23090	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6750_23095	COG4607	ABC-type enterochelin transport system periplasmic component
K6750_23115	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
K6750_23130	COG1609	Transcriptional regulator
K6750_23135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6750_23140	COG1879	ABC-type sugar transport system periplasmic component
K6750_23145	COG1172	Belongs to the binding-protein-dependent transport system permease family
K6750_23150	COG1129	ABC transporter
K6750_23155	COG1869	D-ribose catabolic process
K6750_23160	COG5001	Diguanylate cyclase
K6750_23220	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K6750_23230	COG2205	protein histidine kinase activity
K6750_23230	COG0784	Response regulator, receiver
K6750_23245	COG0330	HflC and HflK could
K6750_23260	COG4175	Glycine betaine
K6750_23260	COG0517	IMP dehydrogenase activity
K6750_23265	COG4176	ABC-type proline glycine betaine transport system permease component
K6750_23280	COG1012	belongs to the aldehyde dehydrogenase family
K6750_23285	COG1309	transcriptional regulator
K6750_23295	COG1028	Short-chain dehydrogenase reductase Sdr
K6750_23310	COG1024	Enoyl-CoA hydratase
K6750_23315	COG1960	acyl-CoA dehydrogenase activity
K6750_23325	COG0183	Belongs to the thiolase family
K6750_23335	COG1960	acyl-CoA dehydrogenase activity
K6750_23340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K6750_23350	COG4770	biotin carboxylase activity
K6750_23365	COG3264	Mechanosensitive ion channel
K6750_23365	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K6750_23370	COG0110	maltose O-acetyltransferase activity
K6750_23375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6750_23380	COG1271	oxidase subunit
K6750_23385	COG1294	oxidase, subunit
K6750_23395	COG0384	phenazine biosynthesis protein PhzF
K6750_23405	COG3527	Alpha-acetolactate decarboxylase
K6750_23415	COG1028	Short-chain dehydrogenase reductase Sdr
K6750_23420	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6750_23445	COG0500	methyltransferase
K6750_23475	COG1022	Amp-dependent synthetase and ligase
K6750_23500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6750_23505	COG1263	PTS System
K6750_23505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6750_23510	COG1486	melibiose metabolic process
K6750_23515	COG2188	Transcriptional regulator
K6750_23520	COG1320	monovalent cation:proton antiporter activity
K6750_23525	COG2212	antiporter activity
K6750_23530	COG1863	multisubunit Na H antiporter MnhE subunit
K6750_23535	COG0651	ATP synthesis coupled electron transport
K6750_23540	COG1006	Multisubunit Na H antiporter MnhC subunit
K6750_23545	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K6750_23545	COG2111	Na H antiporter
K6750_23555	COG0589	response to stress
K6750_23560	COG4221	oxidoreductase activity
K6750_23565	COG0583	DNA-binding transcription factor activity
K6750_23575	COG2814	Major facilitator Superfamily
K6750_23585	COG3179	chitinase
K6750_23630	COG1522	sequence-specific DNA binding
K6750_23665	COG0515	serine threonine protein kinase
K6750_23690	COG3501	Rhs element vgr protein
K6750_23730	COG0739	heme binding
K6750_23745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6750_23785	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K6750_23795	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K6750_23795	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K6750_23810	COG4989	oxidoreductase activity
K6750_23825	COG0038	chloride channel
K6750_23845	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K6750_23860	COG2897	thiosulfate sulfurtransferase activity
K6750_23870	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K6750_23875	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K6750_23885	COG2814	Major facilitator Superfamily
K6750_23890	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K6750_23900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3