locus-tag	class	description
B5S57_00070	COG1192	Involved in chromosome partitioning
B5S57_00095	COG3657	addiction module killer protein
B5S57_00120	COG2433	Pfam Transposase IS66
B5S57_00140	COG1122	ATPase activity
B5S57_00145	COG0076	glutamate decarboxylase activity
B5S57_00170	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
B5S57_00180	COG4774	siderophore transport
B5S57_00185	COG4607	ABC-type enterochelin transport system periplasmic component
B5S57_00190	COG4605	iron ion homeostasis
B5S57_00195	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5S57_00210	COG1028	Short-chain dehydrogenase reductase Sdr
B5S57_00280	COG2433	Pfam Transposase IS66
B5S57_00295	COG1169	isochorismate synthase
B5S57_00300	COG1021	2,3-dihydroxybenzoate-AMP ligase
B5S57_00305	COG3433	isochorismatase activity
B5S57_00305	COG1535	isochorismatase
B5S57_00380	COG2433	Pfam Transposase IS66
B5S57_00465	COG2433	Pfam Transposase IS66
B5S57_00470	COG1162	GTPase activity
B5S57_00480	COG2226	methyltransferase
B5S57_00490	COG0861	Integral membrane protein TerC family
B5S57_00500	COG2249	NAD(P)H dehydrogenase (quinone) activity
B5S57_00505	COG0656	L-ascorbic acid biosynthetic process
B5S57_00530	COG1566	PFAM secretion protein HlyD family protein
B5S57_00555	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B5S57_00565	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B5S57_00580	COG0612	Peptidase, M16
B5S57_00595	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
B5S57_00595	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B5S57_00595	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B5S57_00600	COG1105	Belongs to the carbohydrate kinase PfkB family
B5S57_00605	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B5S57_00605	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B5S57_00610	COG1609	Transcriptional regulator
B5S57_00615	COG0420	3'-5' exonuclease activity
B5S57_00620	COG0419	ATPase involved in DNA repair
B5S57_00625	COG0784	Response regulator, receiver
B5S57_00625	COG2205	protein histidine kinase activity
B5S57_00630	COG0156	8-amino-7-oxononanoate synthase activity
B5S57_00640	COG0038	chloride channel
B5S57_00645	COG0523	cobalamin synthesis protein
B5S57_00650	COG1136	(ABC) transporter
B5S57_00660	COG1136	(ABC) transporter
B5S57_00660	COG0577	efflux transmembrane transporter activity
B5S57_00675	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B5S57_00705	COG3730	PTS system glucitol sorbitol-specific
B5S57_00720	COG1028	Short-chain dehydrogenase reductase Sdr
B5S57_00725	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
B5S57_00730	COG1349	DNA-binding transcription factor activity
B5S57_00735	COG3730	PTS system glucitol sorbitol-specific
B5S57_00750	COG3842	ATPase activity
B5S57_00760	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B5S57_00770	COG2182	Extracellular solute-binding protein
B5S57_00775	COG1175	transmembrane transport
B5S57_00780	COG3833	ABC-type maltose transport systems, permease component
B5S57_00805	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B5S57_00810	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B5S57_00820	COG3005	denitrification pathway
B5S57_00830	COG0243	molybdopterin cofactor binding
B5S57_00840	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B5S57_00845	COG3850	Histidine kinase
B5S57_00850	COG2197	response regulator
B5S57_00855	COG3069	C4-dicarboxylate transmembrane transporter activity
B5S57_00880	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B5S57_00890	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
B5S57_00895	COG0513	Belongs to the DEAD box helicase family
B5S57_00900	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B5S57_00925	COG2433	Pfam Transposase IS66
B5S57_00955	COG2433	Pfam Transposase IS66
B5S57_00970	COG2433	Pfam Transposase IS66
B5S57_01155	COG3040	lipid binding
B5S57_01215	COG2433	Pfam Transposase IS66
B5S57_01245	COG0724	RNA recognition motif
B5S57_01375	COG0023	Translation Initiation Factor
B5S57_01390	COG1181	Belongs to the D-alanine--D-alanine ligase family
B5S57_01400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B5S57_01400	COG1042	CoA-binding domain protein
B5S57_01400	COG0045	succinate-CoA ligase (ADP-forming) activity
B5S57_01405	COG0583	DNA-binding transcription factor activity
B5S57_01425	COG2433	Pfam Transposase IS66
B5S57_01440	COG3140	Belongs to the UPF0181 family
B5S57_01455	COG0745	RESPONSE REGULATOR receiver
B5S57_01465	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
B5S57_01470	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
B5S57_01485	COG3706	GGDEF domain
B5S57_01490	COG1278	Cold shock
B5S57_01500	COG0840	transmembrane signaling receptor activity
B5S57_01515	COG2501	S4 domain
B5S57_01520	COG0625	glutathione transferase activity
B5S57_01535	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B5S57_01540	COG0488	(ABC) transporter
B5S57_01555	COG2050	protein possibly involved in aromatic compounds catabolism
B5S57_01565	COG2824	Alkylphosphonate utilization operon protein PhnA
B5S57_01590	COG2433	Pfam Transposase IS66
B5S57_01620	COG0602	queuosine metabolic process
B5S57_01625	COG1328	CTP reductase activity
B5S57_01630	COG1328	CTP reductase activity
B5S57_01635	COG3706	GGDEF domain
B5S57_01660	COG0640	Transcriptional regulator
B5S57_01675	COG0446	pyridine nucleotide-disulphide oxidoreductase
B5S57_01680	COG3550	peptidyl-serine autophosphorylation
B5S57_01690	COG0697	spore germination
B5S57_01700	COG3344	reverse transcriptase
B5S57_01705	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B5S57_01810	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B5S57_01815	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B5S57_01940	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B5S57_01955	COG3300	MHYT domain
B5S57_01955	COG5001	Diguanylate cyclase
B5S57_01960	COG4191	Histidine kinase
B5S57_01965	COG3852	Histidine kinase
B5S57_01975	COG3437	response regulator, receiver
B5S57_01990	COG2203	Gaf domain
B5S57_01990	COG4251	negative regulation of phosphorylation
B5S57_01990	COG5001	Diguanylate cyclase
B5S57_01990	COG3706	GGDEF domain
B5S57_02000	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B5S57_02005	COG4149	molybdate abc transporter
B5S57_02010	COG0725	ABC transporter, periplasmic molybdate-binding protein
B5S57_02015	COG1492	cobalamin metabolic process
B5S57_02020	COG3111	PFAM Bacterial OB fold (BOF) protein
B5S57_02030	COG3447	MASE1 domain protein
B5S57_02030	COG5002	protein histidine kinase activity
B5S57_02030	COG5001	Diguanylate cyclase
B5S57_02035	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B5S57_02045	COG2207	Transcriptional regulator
B5S57_02065	COG1840	ABC-type Fe3 transport system, periplasmic component
B5S57_02075	COG2271	Major facilitator Superfamily
B5S57_02080	COG0469	pyruvate kinase activity
B5S57_02085	COG2205	protein histidine kinase activity
B5S57_02085	COG2198	Histidine kinase
B5S57_02085	COG0784	Response regulator, receiver
B5S57_02090	COG1879	ABC-type sugar transport system periplasmic component
B5S57_02095	COG1803	Methylglyoxal synthase
B5S57_02100	COG0210	DNA helicase
B5S57_02105	COG1289	transmembrane transporter activity
B5S57_02135	COG0784	Response regulator, receiver
B5S57_02135	COG5002	protein histidine kinase activity
B5S57_02150	COG2827	Endonuclease containing a URI domain
B5S57_02175	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B5S57_02180	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B5S57_02185	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B5S57_02190	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
B5S57_02195	COG0247	lactate metabolic process
B5S57_02200	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B5S57_02205	COG3118	belongs to the thioredoxin family
B5S57_02225	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B5S57_02240	COG2146	nitrite reductase [NAD(P)H] activity
B5S57_02245	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B5S57_02275	COG4176	ABC-type proline glycine betaine transport system permease component
B5S57_02280	COG4175	Glycine betaine
B5S57_02280	COG0517	IMP dehydrogenase activity
B5S57_02295	COG2425	protein containing a von Willebrand factor type A (vWA) domain
B5S57_02310	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
B5S57_02320	COG0513	Belongs to the DEAD box helicase family
B5S57_02325	COG0814	amino acid
B5S57_02335	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B5S57_02340	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B5S57_02350	COG1984	allophanate hydrolase subunit 2
B5S57_02360	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
B5S57_02365	COG4181	ATPase activity
B5S57_02375	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B5S57_02380	COG1716	ATPase activity
B5S57_02380	COG5001	Diguanylate cyclase
B5S57_02390	COG0484	heat shock protein binding
B5S57_02440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B5S57_02445	COG3300	MHYT domain
B5S57_02445	COG5001	Diguanylate cyclase
B5S57_02465	COG0010	Belongs to the arginase family
B5S57_02470	COG1166	arginine decarboxylase activity
B5S57_02485	COG4176	ABC-type proline glycine betaine transport system permease component
B5S57_02490	COG2113	Glycine betaine
B5S57_02505	COG2239	Acts as a magnesium transporter
B5S57_02510	COG0527	aspartate kinase activity
B5S57_02515	COG0662	Cupin 2, conserved barrel domain protein
B5S57_02520	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B5S57_02525	COG0456	acetyltransferase
B5S57_02535	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B5S57_02575	COG0366	Alpha amylase catalytic
B5S57_02595	COG0714	Associated with various cellular activities
B5S57_02615	COG2304	oxidoreductase activity
B5S57_02650	COG1403	HNH endonuclease
B5S57_02655	COG3530	Putative quorum-sensing-regulated virulence factor
B5S57_02660	COG1368	sulfuric ester hydrolase activity
B5S57_02670	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B5S57_02675	COG1063	alcohol dehydrogenase
B5S57_02825	COG0463	Glycosyl transferase, family 2
B5S57_02860	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B5S57_02885	COG1802	Transcriptional regulator
B5S57_02885	COG4626	Terminase
B5S57_02915	COG0582	viral genome integration into host DNA
B5S57_02925	COG1401	restriction endodeoxyribonuclease activity
B5S57_02935	COG1063	alcohol dehydrogenase
B5S57_02940	COG0156	8-amino-7-oxononanoate synthase activity
B5S57_02950	COG0346	lactoylglutathione lyase activity
B5S57_02965	COG2197	response regulator
B5S57_02970	COG3851	Histidine kinase
B5S57_02975	COG2271	Major facilitator Superfamily
B5S57_02990	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B5S57_03010	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B5S57_03015	COG0640	Transcriptional regulator
B5S57_03020	COG0798	PFAM Bile acid sodium symporter
B5S57_03030	COG0659	secondary active sulfate transmembrane transporter activity
B5S57_03035	COG0589	response to stress
B5S57_03050	COG0516	GMP reductase activity
B5S57_03055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B5S57_03080	COG1278	Cold shock
B5S57_03085	COG4681	YaeQ
B5S57_03095	COG3604	Transcriptional regulator
B5S57_03110	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B5S57_03115	COG3217	Mosc domain protein beta barrel domain protein
B5S57_03115	COG0633	Ferredoxin
B5S57_03125	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B5S57_03130	COG2354	Protein conserved in bacteria
B5S57_03135	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B5S57_03205	COG5001	Diguanylate cyclase
B5S57_03215	COG1741	Belongs to the pirin family
B5S57_03225	COG3123	guanosine phosphorylase activity
B5S57_03235	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B5S57_03240	COG1126	abc transporter atp-binding protein
B5S57_03245	COG0765	amino acid transport
B5S57_03250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5S57_03255	COG0765	amino acid transport
B5S57_03260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B5S57_03280	COG0179	Fumarylacetoacetate (FAA) hydrolase
B5S57_03290	COG0697	spore germination
B5S57_03305	COG2814	Major facilitator Superfamily
B5S57_03310	COG0583	DNA-binding transcription factor activity
B5S57_03315	COG5001	Diguanylate cyclase
B5S57_03320	COG0739	heme binding
B5S57_03330	COG0659	secondary active sulfate transmembrane transporter activity
B5S57_03350	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B5S57_03355	COG0581	inorganic phosphate transmembrane transporter activity
B5S57_03360	COG0573	inorganic phosphate transmembrane transporter activity
B5S57_03365	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B5S57_03375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B5S57_03380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B5S57_03400	COG3047	cAMP biosynthetic process
B5S57_03410	COG3397	chitin binding
B5S57_03415	COG2271	Major facilitator Superfamily
B5S57_03420	COG0584	glycerophosphoryl diester phosphodiesterase
B5S57_03430	COG3527	Alpha-acetolactate decarboxylase
B5S57_03455	COG0583	DNA-binding transcription factor activity
B5S57_03460	COG1620	l-lactate permease
B5S57_03465	COG1304	FMN binding
B5S57_03480	COG1881	PFAM PEBP family protein
B5S57_03485	COG3122	Protein conserved in bacteria
B5S57_03495	COG3568	Endonuclease Exonuclease Phosphatase
B5S57_03515	COG1609	Transcriptional regulator
B5S57_03520	COG1472	Belongs to the glycosyl hydrolase 3 family
B5S57_03525	COG3842	ATPase activity
B5S57_03530	COG0395	ABC-type sugar transport system, permease component
B5S57_03545	COG1609	Transcriptional regulator
B5S57_03550	COG4580	involved in the transport of maltose and maltodextrins
B5S57_03570	COG2211	Major facilitator Superfamily
B5S57_03580	COG1067	ATP-dependent peptidase activity
B5S57_03590	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B5S57_03595	COG0363	glucosamine-6-phosphate deaminase activity
B5S57_03605	COG0583	DNA-binding transcription factor activity
B5S57_03630	COG1609	Transcriptional regulator
B5S57_03635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B5S57_03640	COG1879	ABC-type sugar transport system periplasmic component
B5S57_03645	COG1172	Belongs to the binding-protein-dependent transport system permease family
B5S57_03650	COG1129	ABC transporter
B5S57_03655	COG1869	D-ribose catabolic process
B5S57_03670	COG3501	Rhs element vgr protein
B5S57_03680	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B5S57_03685	COG1640	4-alpha-glucanotransferase
B5S57_03690	COG0058	SHG alpha-glucan phosphorylase activity
B5S57_03695	COG2909	trisaccharide binding
B5S57_03720	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B5S57_03775	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B5S57_03785	COG0259	pyridoxamine-phosphate oxidase activity
B5S57_03815	COG0745	RESPONSE REGULATOR receiver
B5S57_03815	COG3706	GGDEF domain
B5S57_03835	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B5S57_03840	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B5S57_03845	COG0840	transmembrane signaling receptor activity
B5S57_03850	COG0835	chemotaxis
B5S57_03855	COG0835	chemotaxis
B5S57_03870	COG0643	Histidine kinase
B5S57_03870	COG2198	Histidine kinase
B5S57_03875	COG0745	RESPONSE REGULATOR receiver
B5S57_03885	COG1444	tRNA N-acetyltransferase activity
B5S57_03950	COG0814	amino acid
B5S57_03980	COG0583	DNA-binding transcription factor activity
B5S57_03985	COG2910	NAD(P)H-binding
B5S57_03995	COG3304	Inner membrane component domain
B5S57_04010	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B5S57_04015	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B5S57_04035	COG0363	glucosamine-6-phosphate deaminase activity
B5S57_04045	COG0739	heme binding
B5S57_04050	COG2213	PTS system mannitol-specific
B5S57_04050	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B5S57_04055	COG0246	Mannitol dehydrogenase
B5S57_04060	COG3722	fumarate hydratase activity
B5S57_04070	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B5S57_04075	COG1301	dicarboxylic acid transport
B5S57_04080	COG2259	Doxx family
B5S57_04105	COG1846	Transcriptional regulator
B5S57_04115	COG4943	cyclic-guanylate-specific phosphodiesterase activity
B5S57_04120	COG3046	protein related to deoxyribodipyrimidine photolyase
B5S57_04125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B5S57_04130	COG0842	Transport permease protein
B5S57_04135	COG1131	(ABC) transporter
B5S57_04150	COG3842	ATPase activity
B5S57_04160	COG1176	ABC-type spermidine putrescine transport system, permease component I
B5S57_04180	COG0513	Belongs to the DEAD box helicase family
B5S57_04185	COG0251	oxidation-reduction process
B5S57_04190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B5S57_04200	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B5S57_04205	COG1328	CTP reductase activity
B5S57_04215	COG2130	NADP-dependent
B5S57_04220	COG1309	transcriptional regulator
B5S57_04235	COG0745	RESPONSE REGULATOR receiver
B5S57_04245	COG0564	pseudouridine synthase activity
B5S57_04335	COG3501	Rhs element vgr protein
B5S57_04390	COG0471	metal ion transport
B5S57_04395	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
B5S57_04405	COG2188	Transcriptional regulator
B5S57_04410	COG1131	(ABC) transporter
B5S57_04450	COG0671	phosphoesterase, PA-phosphatase related
B5S57_04455	COG4399	Belongs to the UPF0754 family
B5S57_04460	COG1132	(ABC) transporter
B5S57_04480	COG3623	hexulose-6-phosphate isomerase
B5S57_04485	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
B5S57_04490	COG0561	phosphatase activity
B5S57_04560	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
B5S57_04570	COG1999	signal sequence binding
B5S57_04585	COG0786	glutamate:sodium symporter activity
B5S57_04610	COG1566	PFAM secretion protein HlyD family protein
B5S57_04620	COG3706	GGDEF domain
B5S57_04635	COG0813	purine-nucleoside phosphorylase activity
B5S57_04640	COG3272	Protein of unknown function (DUF1722)
B5S57_04645	COG0789	Transcriptional regulator
B5S57_04650	COG0415	Belongs to the DNA photolyase family
B5S57_04655	COG1388	LysM domain
B5S57_04655	COG1376	ErfK ybiS ycfS ynhG family protein
B5S57_04665	COG0513	Belongs to the DEAD box helicase family
B5S57_04705	COG0366	Alpha amylase catalytic
B5S57_04710	COG4989	oxidoreductase activity
B5S57_04720	COG1136	(ABC) transporter
B5S57_04720	COG0577	efflux transmembrane transporter activity
B5S57_04725	COG4591	ABC-type transport system involved in lipoprotein release permease component
B5S57_04740	COG0745	RESPONSE REGULATOR receiver
B5S57_04740	COG2972	Histidine kinase
B5S57_04745	COG3279	Response regulator of the LytR AlgR family
B5S57_04750	COG2203	Gaf domain
B5S57_04750	COG4251	negative regulation of phosphorylation
B5S57_04750	COG5001	Diguanylate cyclase
B5S57_04750	COG3706	GGDEF domain
B5S57_04760	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
B5S57_04770	COG3437	response regulator, receiver
B5S57_04775	COG2205	protein histidine kinase activity
B5S57_04775	COG3437	response regulator, receiver
B5S57_04775	COG4999	Histidine kinase
B5S57_04775	COG3850	Histidine kinase
B5S57_04785	COG0531	amino acid
B5S57_04810	COG0784	Response regulator, receiver
B5S57_04810	COG5002	protein histidine kinase activity
B5S57_04810	COG2205	protein histidine kinase activity
B5S57_04825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B5S57_04830	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B5S57_04845	COG0673	inositol 2-dehydrogenase activity
B5S57_04850	COG1765	OsmC-like protein
B5S57_04855	COG0110	maltose O-acetyltransferase activity
B5S57_04870	COG0583	DNA-binding transcription factor activity
B5S57_04880	COG0583	DNA-binding transcription factor activity
B5S57_04885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B5S57_04890	COG3186	Phenylalanine-4-hydroxylase
B5S57_04900	COG0840	transmembrane signaling receptor activity
B5S57_04905	COG0534	Mate efflux family protein
B5S57_04910	COG2207	Transcriptional regulator
B5S57_04915	COG0784	Response regulator, receiver
B5S57_04915	COG3437	response regulator, receiver
B5S57_04920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5S57_04920	COG4191	Histidine kinase
B5S57_04930	COG2814	Major facilitator Superfamily
B5S57_04940	COG0443	Heat shock 70 kDa protein
B5S57_04955	COG3240	lipase activity
B5S57_04965	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
B5S57_04970	COG5380	lipid catabolic process
B5S57_04975	COG4412	M6 family metalloprotease domain protein
B5S57_04975	COG3291	Pkd domain containing protein
B5S57_04990	COG4934	collagen metabolic process
B5S57_05010	COG4607	ABC-type enterochelin transport system periplasmic component
B5S57_05015	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5S57_05020	COG4605	iron ion homeostasis
B5S57_05025	COG4604	ABC transporter, ATP-binding protein
B5S57_05035	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B5S57_05050	COG3344	reverse transcriptase
B5S57_05075	COG2433	Pfam Transposase IS66
B5S57_05090	COG1357	PFAM Pentapeptide repeats (8 copies)
B5S57_05100	COG2433	Pfam Transposase IS66
B5S57_05120	COG0602	queuosine metabolic process
B5S57_05130	COG0189	ligase activity
B5S57_05130	COG4067	protein conserved in archaea
B5S57_05145	COG4166	transmembrane transport
B5S57_05150	COG4174	ABC transporter (Permease)
B5S57_05155	COG4239	(ABC) transporter, permease
B5S57_05160	COG4172	Belongs to the ABC transporter superfamily
B5S57_05165	COG2203	Gaf domain
B5S57_05165	COG4251	negative regulation of phosphorylation
B5S57_05165	COG5001	Diguanylate cyclase
B5S57_05165	COG3706	GGDEF domain
B5S57_05175	COG3038	cytochrome b561
B5S57_05180	COG2353	YceI-like domain
B5S57_05185	COG0840	transmembrane signaling receptor activity
B5S57_05190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B5S57_05195	COG0545	Peptidyl-prolyl cis-trans isomerase
B5S57_05210	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B5S57_05230	COG2897	thiosulfate sulfurtransferase activity
B5S57_05235	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B5S57_05240	COG0303	'Molybdopterin
B5S57_05245	COG0302	gtp cyclohydrolase
B5S57_05250	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B5S57_05250	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B5S57_05255	COG2759	Belongs to the formate--tetrahydrofolate ligase family
B5S57_05260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B5S57_05265	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B5S57_05275	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
B5S57_05280	COG1011	Hydrolase
B5S57_05285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B5S57_05290	COG2188	Transcriptional regulator
B5S57_05310	COG2116	formate transmembrane transporter activity
B5S57_05315	COG0583	DNA-binding transcription factor activity
B5S57_05325	COG3593	DNA synthesis involved in DNA repair
B5S57_05330	COG0737	Belongs to the 5'-nucleotidase family
B5S57_05335	COG0861	Integral membrane protein TerC family
B5S57_05340	COG2433	Pfam Transposase IS66
B5S57_05360	COG0500	methyltransferase
B5S57_05375	COG2433	Pfam Transposase IS66
B5S57_05465	COG2433	Pfam Transposase IS66
B5S57_05540	COG0606	chelatase, subunit chli
B5S57_05550	COG3978	acetolactate synthase activity
B5S57_05555	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B5S57_05560	COG0129	dihydroxy-acid dehydratase activity
B5S57_05570	COG0604	alcohol dehydrogenase
B5S57_05595	COG2119	membrane
B5S57_05600	COG0752	glycyl-tRNA synthetase alpha subunit
B5S57_05610	COG3977	Valine--pyruvate aminotransferase
B5S57_05615	COG0071	Belongs to the small heat shock protein (HSP20) family
B5S57_05625	COG0187	DNA topoisomerase II activity
B5S57_05630	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B5S57_05635	COG0592	DNA-directed DNA polymerase activity
B5S57_05655	COG1126	abc transporter atp-binding protein
B5S57_05670	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B5S57_05675	COG0706	membrane insertase activity
B5S57_05685	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B5S57_05690	COG0445	tRNA wobble uridine modification
B5S57_05700	COG1192	Involved in chromosome partitioning
B5S57_05705	COG1475	DNA binding
B5S57_05710	COG3312	ion transport
B5S57_05715	COG0356	it plays a direct role in the translocation of protons across the membrane
B5S57_05725	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B5S57_05730	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B5S57_05735	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B5S57_05740	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B5S57_05745	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B5S57_05750	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B5S57_05760	COG2814	Major facilitator Superfamily
B5S57_05765	COG0583	DNA-binding transcription factor activity
B5S57_05770	COG0183	Belongs to the thiolase family
B5S57_05780	COG1739	Uncharacterized protein family UPF0029
B5S57_05785	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B5S57_05790	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
B5S57_05845	COG0352	thiamine-phosphate diphosphorylase activity
B5S57_05855	COG2104	thiamine diphosphate biosynthetic process
B5S57_05865	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B5S57_05870	COG0006	proline dipeptidase activity
B5S57_05870	COG0006	proline dipeptidase activity
B5S57_05895	COG1522	sequence-specific DNA binding
B5S57_05900	COG0742	ribosomal rna small subunit methyltransferase
B5S57_05910	COG0697	spore germination
B5S57_05915	COG0589	response to stress
B5S57_05920	COG1528	Iron-storage protein
B5S57_05935	COG2081	HI0933 family
B5S57_05945	COG1172	Belongs to the binding-protein-dependent transport system permease family
B5S57_05950	COG1129	ABC transporter
B5S57_05955	COG1879	ABC-type sugar transport system periplasmic component
B5S57_05960	COG1069	ribulokinase activity
B5S57_05970	COG2160	L-arabinose isomerase activity
B5S57_05990	COG1322	Protein conserved in bacteria
B5S57_06005	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B5S57_06015	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B5S57_06020	COG0805	protein transport
B5S57_06025	COG0084	hydrolase, TatD family'
B5S57_06035	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B5S57_06035	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B5S57_06040	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B5S57_06065	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B5S57_06070	COG0583	DNA-binding transcription factor activity
B5S57_06080	COG2960	long-chain fatty acid transporting porin activity
B5S57_06085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B5S57_06090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B5S57_06095	COG1309	transcriptional regulator
B5S57_06150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5S57_06205	COG2433	Pfam Transposase IS66
B5S57_06225	COG3081	Nucleoid-associated protein
B5S57_06245	COG2433	Pfam Transposase IS66
B5S57_06260	COG5290	Psort location Cytoplasmic, score
B5S57_06300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B5S57_06305	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B5S57_06310	COG0339	signal peptide processing
B5S57_06315	COG0210	DNA helicase
B5S57_06320	COG1280	lysine exporter protein (LysE YggA)
B5S57_06330	COG2962	Rard protein
B5S57_06335	COG0514	ATP-dependent DNA helicase (RecQ)
B5S57_06355	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
B5S57_06360	COG1263	PTS System
B5S57_06360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B5S57_06365	COG1132	(ABC) transporter
B5S57_06370	COG4774	siderophore transport
B5S57_06375	COG1120	ATPase activity
B5S57_06400	COG0612	Peptidase, M16
B5S57_06425	COG2433	Pfam Transposase IS66
B5S57_06450	COG2433	Pfam Transposase IS66
B5S57_06540	COG1561	YicC-like family, N-terminal region
B5S57_06545	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B5S57_06555	COG1560	Kdo2-lipid A biosynthetic process
B5S57_06560	COG1560	Kdo2-lipid A biosynthetic process
B5S57_06565	COG1309	transcriptional regulator
B5S57_06570	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B5S57_06585	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B5S57_06595	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B5S57_06600	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B5S57_06605	COG0859	PFAM glycosyl transferase family 9
B5S57_06610	COG0463	Glycosyl transferase, family 2
B5S57_06615	COG0859	PFAM glycosyl transferase family 9
B5S57_06620	COG3642	lipopolysaccharide core region biosynthetic process
B5S57_06635	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B5S57_06645	COG1519	Transferase
B5S57_06660	COG0859	PFAM glycosyl transferase family 9
B5S57_06665	COG3307	-O-antigen
B5S57_06675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B5S57_06700	COG1682	transport, permease protein
B5S57_06730	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B5S57_06745	COG0028	Belongs to the TPP enzyme family
B5S57_06755	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B5S57_06765	COG0463	Glycosyl transferase, family 2
B5S57_06795	COG3754	Rhamnan synthesis protein F
B5S57_06820	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B5S57_06830	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B5S57_06850	COG1596	polysaccharide export
B5S57_06855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B5S57_06895	COG0438	transferase activity, transferring glycosyl groups
B5S57_06910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B5S57_06915	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B5S57_06925	COG0668	transmembrane transport
B5S57_06930	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B5S57_06935	COG3068	Protein conserved in bacteria
B5S57_06940	COG2852	Protein conserved in bacteria
B5S57_06945	COG1253	flavin adenine dinucleotide binding
B5S57_06950	COG0776	regulation of translation
B5S57_06960	COG0151	Belongs to the GarS family
B5S57_06970	COG0789	Transcriptional regulator
B5S57_06980	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
B5S57_06985	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B5S57_06990	COG2264	protein methyltransferase activity
B5S57_06995	COG0439	Biotin carboxylase
B5S57_07000	COG0511	ligase activity, forming carbon-carbon bonds
B5S57_07005	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B5S57_07010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B5S57_07025	COG2814	Major facilitator Superfamily
B5S57_07030	COG2205	protein histidine kinase activity
B5S57_07030	COG2198	Histidine kinase
B5S57_07030	COG0784	Response regulator, receiver
B5S57_07035	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B5S57_07045	COG3263	regulation of cellular component size
B5S57_07055	COG4232	protein-disulfide reductase activity
B5S57_07060	COG1438	arginine binding
B5S57_07065	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
B5S57_07070	COG0540	Belongs to the ATCase OTCase family
B5S57_07080	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B5S57_07085	COG0549	Belongs to the carbamate kinase family
B5S57_07095	COG1288	antiporter activity
B5S57_07100	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
B5S57_07105	COG1027	Aspartate ammonia-lyase
B5S57_07110	COG3030	protein affecting phage T7 exclusion by the F plasmid
B5S57_07115	COG1278	Cold shock
B5S57_07120	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B5S57_07125	COG2205	protein histidine kinase activity
B5S57_07130	COG0745	RESPONSE REGULATOR receiver
B5S57_07140	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B5S57_07145	COG0205	6-phosphofructokinase activity
B5S57_07150	COG1494	fructose-1,6-bisphosphatase
B5S57_07160	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B5S57_07165	COG0527	aspartate kinase activity
B5S57_07165	COG0460	homoserine dehydrogenase
B5S57_07170	COG0626	cystathionine gamma-synthase activity
B5S57_07180	COG0281	malic enzyme
B5S57_07190	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B5S57_07195	COG1609	Transcriptional regulator
B5S57_07215	COG1575	Belongs to the MenA family. Type 1 subfamily
B5S57_07220	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B5S57_07225	COG0534	Mate efflux family protein
B5S57_07230	COG0149	triose-phosphate isomerase activity
B5S57_07260	COG0459	protein refolding
B5S57_07275	COG1509	lysine 2,3-aminomutase activity
B5S57_07280	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B5S57_07290	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
B5S57_07295	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B5S57_07300	COG1053	succinate dehydrogenase
B5S57_07305	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
B5S57_07310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B5S57_07320	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B5S57_07325	COG1045	serine acetyltransferase
B5S57_07345	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B5S57_07350	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B5S57_07360	COG0165	Argininosuccinate lyase
B5S57_07360	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B5S57_07370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B5S57_07375	COG0678	peroxiredoxin activity
B5S57_07375	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B5S57_07385	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B5S57_07415	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B5S57_07430	COG0338	D12 class N6 adenine-specific DNA methyltransferase
B5S57_07435	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B5S57_07440	COG0546	phosphoglycolate phosphatase activity
B5S57_07445	COG0180	Tryptophanyl-tRNA synthetase
B5S57_07460	COG0583	DNA-binding transcription factor activity
B5S57_07470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B5S57_07485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B5S57_07505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B5S57_07510	COG3954	Phosphoribulokinase
B5S57_07520	COG0429	hydrolase of the alpha beta-hydrolase fold
B5S57_07530	COG0488	(ABC) transporter
B5S57_07535	COG2249	NAD(P)H dehydrogenase (quinone) activity
B5S57_07545	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
B5S57_07550	COG1047	Peptidyl-prolyl cis-trans
B5S57_07560	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B5S57_07570	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
B5S57_07575	COG0557	exoribonuclease II activity
B5S57_07580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B5S57_07585	COG0051	transcription antitermination factor activity, RNA binding
B5S57_07610	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B5S57_07635	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B5S57_07640	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B5S57_07660	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B5S57_07665	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B5S57_07690	COG0201	protein transport
B5S57_07700	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B5S57_07705	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B5S57_07710	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B5S57_07720	COG0203	ribosomal protein L17
B5S57_07725	COG0545	Peptidyl-prolyl cis-trans isomerase
B5S57_07730	COG3061	Opacity-associated protein A
B5S57_07730	COG3266	domain, Protein
B5S57_07735	COG2153	protein acetylation
B5S57_07740	COG0513	Belongs to the DEAD box helicase family
B5S57_07780	COG0737	Belongs to the 5'-nucleotidase family
B5S57_07785	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B5S57_07785	COG1648	precorrin-2 dehydrogenase activity
B5S57_07790	COG0175	sulfate reduction
B5S57_07795	COG2895	sulfate adenylyltransferase (ATP) activity
B5S57_07800	COG0529	Catalyzes the synthesis of activated sulfate
B5S57_07835	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
B5S57_07840	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B5S57_07845	COG0729	surface antigen
B5S57_07850	COG2911	Protein conserved in bacteria
B5S57_07855	COG2105	PFAM AIG2 family protein
B5S57_07865	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B5S57_07870	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
B5S57_07875	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B5S57_07880	COG0163	prenyltransferase activity
B5S57_07885	COG4143	(ABC) transporter
B5S57_07890	COG1178	ABC-type Fe3 transport system permease component
B5S57_07895	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
B5S57_07900	COG3028	Belongs to the UPF0307 family
B5S57_07905	COG0312	modulator of DNA gyrase
B5S57_07910	COG2239	Acts as a magnesium transporter
B5S57_07915	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B5S57_07925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B5S57_07930	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B5S57_07940	COG1137	ATPase activity
B5S57_07945	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
B5S57_07955	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B5S57_07960	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B5S57_07960	COG0517	IMP dehydrogenase activity
B5S57_07970	COG1127	ABC transporter
B5S57_07975	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B5S57_07980	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B5S57_07985	COG2854	intermembrane phospholipid transfer
B5S57_07995	COG5007	Belongs to the BolA IbaG family
B5S57_08000	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B5S57_08005	COG0204	Acyl-transferase
B5S57_08020	COG0251	oxidation-reduction process
B5S57_08025	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
B5S57_08040	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B5S57_08050	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B5S57_08060	COG0564	pseudouridine synthase activity
B5S57_08065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B5S57_08070	COG0525	valine-tRNA ligase activity
B5S57_08075	COG2927	DNA polymerase III (CHI subunit)
B5S57_08080	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B5S57_08085	COG0795	lipopolysaccharide-transporting ATPase activity
B5S57_08090	COG0795	lipopolysaccharide-transporting ATPase activity
B5S57_08150	COG0066	3-isopropylmalate dehydratase activity
B5S57_08160	COG0473	3-isopropylmalate dehydrogenase activity
B5S57_08165	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B5S57_08180	COG0583	DNA-binding transcription factor activity
B5S57_08185	COG1022	Amp-dependent synthetase and ligase
B5S57_08190	COG0028	Belongs to the TPP enzyme family
B5S57_08200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B5S57_08210	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B5S57_08220	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
B5S57_08230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B5S57_08235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B5S57_08250	COG0354	folic acid binding
B5S57_08255	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
B5S57_08265	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B5S57_08270	COG1595	DNA-templated transcription, initiation
B5S57_08285	COG3086	response to oxidative stress
B5S57_08290	COG0481	GTPase activity
B5S57_08295	COG0681	Belongs to the peptidase S26 family
B5S57_08320	COG0736	holo-[acyl-carrier-protein] synthase activity
B5S57_08325	COG3437	response regulator, receiver
B5S57_08325	COG3850	Histidine kinase
B5S57_08325	COG4999	Histidine kinase
B5S57_08325	COG2205	protein histidine kinase activity
B5S57_08330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B5S57_08335	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B5S57_08340	COG3956	TIGRFAM MazG family protein
B5S57_08345	COG0504	CTP synthase activity
B5S57_08355	COG0617	tRNA 3'-terminal CCA addition
B5S57_08360	COG3267	Type II secretory pathway component ExeA
B5S57_08360	COG3409	Peptidoglycan-binding domain 1 protein
B5S57_08370	COG4991	sh3 domain protein
B5S57_08375	COG0306	phosphate transporter
B5S57_08380	COG1392	Phosphate transport regulator
B5S57_08385	COG3025	triphosphatase activity
B5S57_08400	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B5S57_08410	COG1538	Outer membrane efflux protein
B5S57_08415	COG0494	nUDIX hydrolase
B5S57_08420	COG3151	Protein conserved in bacteria
B5S57_08430	COG3150	esterase
B5S57_08435	COG0187	DNA topoisomerase II activity
B5S57_08440	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B5S57_08445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B5S57_08450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B5S57_08455	COG3105	Protein conserved in bacteria
B5S57_08460	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B5S57_08480	COG0723	plastoquinol--plastocyanin reductase activity
B5S57_08485	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B5S57_08490	COG2857	Cytochrome c1
B5S57_08495	COG0625	glutathione transferase activity
B5S57_08500	COG2969	positive regulation of protein catabolic process
B5S57_08510	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B5S57_08520	COG3107	peptidoglycan biosynthetic process
B5S57_08525	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B5S57_08540	COG3116	cell division
B5S57_08545	COG0768	penicillin binding
B5S57_08550	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B5S57_08555	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B5S57_08560	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B5S57_08565	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B5S57_08570	COG0772	Belongs to the SEDS family
B5S57_08575	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B5S57_08580	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B5S57_08585	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B5S57_08590	COG0849	cell division
B5S57_08595	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B5S57_08600	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
B5S57_08610	COG0653	protein targeting
B5S57_08615	COG0494	nUDIX hydrolase
B5S57_08625	COG0505	Belongs to the CarA family
B5S57_08635	COG0730	response to heat
B5S57_08640	COG0583	DNA-binding transcription factor activity
B5S57_08645	COG2860	membrane
B5S57_08650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B5S57_08675	COG0493	'glutamate synthase
B5S57_08680	COG0067	glutamate synthase
B5S57_08680	COG0070	glutamate synthase
B5S57_08680	COG0069	glutamate synthase activity
B5S57_08690	COG0067	glutamate synthase
B5S57_08690	COG0070	glutamate synthase
B5S57_08690	COG0069	glutamate synthase activity
B5S57_08695	COG1242	4 iron, 4 sulfur cluster binding
B5S57_08700	COG5002	protein histidine kinase activity
B5S57_08700	COG0784	Response regulator, receiver
B5S57_08700	COG2198	Histidine kinase
B5S57_08710	COG0745	RESPONSE REGULATOR receiver
B5S57_08715	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B5S57_08730	COG0083	homoserine kinase activity
B5S57_08735	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B5S57_08740	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
B5S57_08745	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B5S57_08750	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B5S57_08765	COG1115	amino acid carrier protein
B5S57_08775	COG0084	hydrolase, TatD family'
B5S57_08780	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B5S57_08785	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B5S57_08795	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B5S57_08800	COG0813	purine-nucleoside phosphorylase activity
B5S57_08810	COG0560	Phosphoserine phosphatase
B5S57_08820	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B5S57_08825	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B5S57_08830	COG4628	conserved protein (DUF2132)
B5S57_08835	COG1022	Amp-dependent synthetase and ligase
B5S57_08840	COG0784	Response regulator, receiver
B5S57_08840	COG3437	response regulator, receiver
B5S57_08855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B5S57_08860	COG1085	galactose-1-phosphate uridylyltransferase
B5S57_08870	COG1609	Transcriptional regulator
B5S57_08900	COG2171	N-acyltransferase activity
B5S57_08905	COG3141	response to X-ray
B5S57_08920	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
B5S57_08925	COG1074	ATP-dependent DNA helicase activity
B5S57_08930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B5S57_08940	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B5S57_08940	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B5S57_08950	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
B5S57_08955	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B5S57_08960	COG2166	iron-sulfur cluster assembly
B5S57_08965	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B5S57_08975	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B5S57_08990	COG1595	DNA-templated transcription, initiation
B5S57_09000	COG2211	Major facilitator Superfamily
B5S57_09020	COG0271	Belongs to the BolA IbaG family
B5S57_09055	COG1477	protein flavinylation
B5S57_09065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B5S57_09080	COG0733	neurotransmitter:sodium symporter activity
B5S57_09090	COG0189	ligase activity
B5S57_09095	COG4067	protein conserved in archaea
B5S57_09095	COG0189	ligase activity
B5S57_09100	COG2195	Cleaves the N-terminal amino acid of tripeptides
B5S57_09105	COG2252	PERMEase
B5S57_09125	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B5S57_09130	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B5S57_09140	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B5S57_09140	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B5S57_09165	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B5S57_09170	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B5S57_09185	COG0024	Methionine aminopeptidase
B5S57_09190	COG0052	Belongs to the universal ribosomal protein uS2 family
B5S57_09195	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B5S57_09205	COG0233	cytoplasmic translational termination
B5S57_09210	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B5S57_09215	COG0575	Belongs to the CDS family
B5S57_09220	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B5S57_09225	COG0750	zinc metalloprotease
B5S57_09235	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
B5S57_09240	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B5S57_09245	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B5S57_09255	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B5S57_09265	COG0587	DNA-directed DNA polymerase activity
B5S57_09270	COG0825	malonyl-CoA metabolic process
B5S57_09275	COG0037	tRNA processing
B5S57_09285	COG0347	Belongs to the P(II) protein family
B5S57_09300	COG0741	lytic transglycosylase activity
B5S57_09300	COG1388	LysM domain
B5S57_09305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B5S57_09310	COG2226	methyltransferase
B5S57_09320	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B5S57_09335	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B5S57_09340	COG0121	glutamine amidotransferase
B5S57_09345	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B5S57_09350	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B5S57_09355	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B5S57_09360	COG1187	pseudouridine synthase activity
B5S57_09385	COG2608	mercury ion transmembrane transporter activity
B5S57_09385	COG2217	Heavy metal translocating P-type atpase
B5S57_09430	COG2747	anti-sigma28 factor FlgM
B5S57_09440	COG0784	Response regulator, receiver
B5S57_09440	COG0835	chemotaxis
B5S57_09450	COG1815	bacterial-type flagellum-dependent cell motility
B5S57_09455	COG1558	bacterial-type flagellum-dependent cell motility
B5S57_09460	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B5S57_09465	COG1749	Flagellar hook protein flgE
B5S57_09470	COG4787	bacterial-type flagellum-dependent cell motility
B5S57_09475	COG4786	Flagellar basal body rod
B5S57_09480	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
B5S57_09485	COG1706	bacterial-type flagellum-dependent cell motility
B5S57_09490	COG1705	Flagellar rod assembly protein muramidase FlgJ
B5S57_09490	COG3951	Flagellar rod assembly protein muramidase FlgJ
B5S57_09500	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B5S57_09595	COG0193	aminoacyl-tRNA hydrolase activity
B5S57_09610	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
B5S57_09615	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B5S57_09620	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B5S57_09625	COG2890	protein-(glutamine-N5) methyltransferase activity
B5S57_09630	COG3094	Invasion gene expression up-regulator, SirB
B5S57_09635	COG2912	Transglutaminase-like superfamily
B5S57_09640	COG2877	3-deoxy-8-phosphooctulonate synthase activity
B5S57_09650	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B5S57_09655	COG2233	PERMEase
B5S57_09675	COG1393	Belongs to the ArsC family
B5S57_09680	COG4783	chaperone-mediated protein folding
B5S57_09700	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B5S57_09730	COG0210	DNA helicase
B5S57_09765	COG2801	Transposase and inactivated derivatives
B5S57_09775	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B5S57_09800	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B5S57_09810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B5S57_09830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B5S57_09835	COG1393	Belongs to the ArsC family
B5S57_09860	COG2837	iron assimilation
B5S57_09885	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
B5S57_09895	COG1516	flagellar protein fliS
B5S57_09900	COG2204	response regulator
B5S57_09905	COG4191	Histidine kinase
B5S57_09910	COG2204	response regulator
B5S57_09915	COG1677	Flagellar hook-basal body complex protein FliE
B5S57_09925	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B5S57_09975	COG1987	bacterial-type flagellum assembly
B5S57_09980	COG1684	flagellar biosynthetic protein fliR
B5S57_09990	COG2840	Smr protein MutS2
B5S57_09995	COG2890	protein-(glutamine-N5) methyltransferase activity
B5S57_10000	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B5S57_10005	COG2860	membrane
B5S57_10010	COG3101	peptidyl-lysine hydroxylation
B5S57_10020	COG0431	NADPH-dependent FMN reductase
B5S57_10025	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
B5S57_10025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5S57_10030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B5S57_10035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B5S57_10040	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B5S57_10045	COG0735	belongs to the Fur family
B5S57_10055	COG0583	DNA-binding transcription factor activity
B5S57_10065	COG1346	cytolysis
B5S57_10070	COG0716	FMN binding
B5S57_10080	COG0596	Alpha beta hydrolase
B5S57_10085	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
B5S57_10090	COG0033	Phosphoglucomutase
B5S57_10100	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B5S57_10110	COG2009	succinate dehydrogenase
B5S57_10115	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
B5S57_10130	COG0567	Dehydrogenase, E1 component
B5S57_10135	COG0508	dehydrogenase complex catalyzes the overall conversion of
B5S57_10150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B5S57_10155	COG1121	(ABC) transporter
B5S57_10160	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
B5S57_10165	COG4977	sequence-specific DNA binding
B5S57_10170	COG1918	ferrous iron import across plasma membrane
B5S57_10195	COG3102	Protein conserved in bacteria
B5S57_10200	COG1025	Belongs to the peptidase M16 family
B5S57_10205	COG2062	phosphohistidine phosphatase, SixA
B5S57_10210	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B5S57_10220	COG0455	bacterial-type flagellum organization
B5S57_10235	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
B5S57_10240	COG0643	Histidine kinase
B5S57_10240	COG2198	Histidine kinase
B5S57_10245	COG2201	protein-glutamate methylesterase activity
B5S57_10250	COG1192	Involved in chromosome partitioning
B5S57_10260	COG0835	chemotaxis
B5S57_10270	COG4133	protoheme IX ABC transporter activity
B5S57_10275	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B5S57_10280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B5S57_10290	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
B5S57_10295	COG1138	Cytochrome C-type biogenesis protein
B5S57_10300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B5S57_10315	COG2853	Lipoprotein
B5S57_10335	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B5S57_10340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B5S57_10355	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B5S57_10360	COG0243	molybdopterin cofactor binding
B5S57_10370	COG3083	sulfuric ester hydrolase activity
B5S57_10375	COG3082	Protein of unknown function (DUF1414)
B5S57_10390	COG1757	Na H antiporter
B5S57_10395	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B5S57_10400	COG2095	MarC family integral membrane protein
B5S57_10405	COG1454	alcohol dehydrogenase
B5S57_10405	COG1012	belongs to the aldehyde dehydrogenase family
B5S57_10415	COG1530	ribonuclease E activity
B5S57_10420	COG0564	pseudouridine synthase activity
B5S57_10425	COG0424	maF-like protein
B5S57_10430	COG1399	metal-binding, possibly nucleic acid-binding protein
B5S57_10435	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B5S57_10445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B5S57_10470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B5S57_10475	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B5S57_10480	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B5S57_10485	COG0470	DNA polymerase III
B5S57_10490	COG0084	hydrolase, TatD family'
B5S57_10495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B5S57_10495	COG1263	PTS System
B5S57_10500	COG0733	neurotransmitter:sodium symporter activity
B5S57_10510	COG4667	esterase of the alpha-beta hydrolase superfamily
B5S57_10520	COG1940	carbohydrate kinase activity
B5S57_10525	COG0784	Response regulator, receiver
B5S57_10525	COG0835	chemotaxis
B5S57_10530	COG1028	Short-chain dehydrogenase reductase Sdr
B5S57_10535	COG0616	signal peptide processing
B5S57_10550	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B5S57_10555	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
B5S57_10560	COG0436	Aminotransferase
B5S57_10570	COG1169	isochorismate synthase
B5S57_10575	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B5S57_10585	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B5S57_10590	COG1441	menaquinone biosynthetic process
B5S57_10635	COG1522	sequence-specific DNA binding
B5S57_10640	COG1946	Acyl-CoA thioesterase
B5S57_10645	COG3126	Type III secretion system lipoprotein chaperone (YscW)
B5S57_10660	COG3706	GGDEF domain
B5S57_10685	COG1022	Amp-dependent synthetase and ligase
B5S57_10695	COG4221	oxidoreductase activity
B5S57_10705	COG0745	RESPONSE REGULATOR receiver
B5S57_10710	COG0642	Histidine kinase
B5S57_10715	COG2194	sulfuric ester hydrolase activity
B5S57_10730	COG2985	domain, Protein
B5S57_10740	COG3850	Histidine kinase
B5S57_10740	COG5002	protein histidine kinase activity
B5S57_10755	COG1609	Transcriptional regulator
B5S57_10760	COG0129	dihydroxy-acid dehydratase activity
B5S57_10765	COG3265	gluconokinase activity
B5S57_10770	COG2610	gluconate transmembrane transporter activity
B5S57_10775	COG0800	Aldolase
B5S57_10800	COG1028	Short-chain dehydrogenase reductase Sdr
B5S57_10805	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B5S57_10810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B5S57_10840	COG1216	Glycosyl transferase, family 2
B5S57_10860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B5S57_10865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B5S57_10900	COG0784	Response regulator, receiver
B5S57_10900	COG5002	protein histidine kinase activity
B5S57_10915	COG0601	transmembrane transport
B5S57_10920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5S57_10925	COG0444	Belongs to the ABC transporter superfamily
B5S57_10935	COG0435	Glutathione S-transferase
B5S57_10940	COG0857	belongs to the CobB CobQ family
B5S57_10940	COG0280	phosphate acetyltransferase
B5S57_10945	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B5S57_10950	COG3092	negative regulation of chromosome organization
B5S57_10960	COG4120	Belongs to the binding-protein-dependent transport system permease family
B5S57_10970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B5S57_10975	COG0653	protein targeting
B5S57_10980	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B5S57_10985	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B5S57_10995	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B5S57_11005	COG0156	8-amino-7-oxononanoate synthase activity
B5S57_11010	COG2226	methyltransferase
B5S57_11015	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B5S57_11025	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B5S57_11030	COG2186	Transcriptional regulator
B5S57_11045	COG0537	adenosine 5'-monophosphoramidase activity
B5S57_11075	COG1252	NADH dehydrogenase
B5S57_11090	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B5S57_11100	COG4591	ABC-type transport system involved in lipoprotein release permease component
B5S57_11105	COG1136	(ABC) transporter
B5S57_11110	COG4591	ABC-type transport system involved in lipoprotein release permease component
B5S57_11120	COG0658	competence protein
B5S57_11120	COG2333	competence protein COMEC
B5S57_11125	COG1132	(ABC) transporter
B5S57_11140	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B5S57_11150	COG2719	SpoVR family
B5S57_11155	COG2718	Belongs to the UPF0229 family
B5S57_11160	COG2766	serine protein kinase
B5S57_11175	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B5S57_11190	COG1882	Formate acetyltransferase
B5S57_11215	COG4215	(ABC) transporter
B5S57_11220	COG4160	amino acid transport
B5S57_11225	COG0708	Exodeoxyribonuclease III
B5S57_11230	COG0840	transmembrane signaling receptor activity
B5S57_11240	COG3923	Primosomal replication protein n
B5S57_11250	COG1199	ATP-dependent helicase activity
B5S57_11260	COG3012	SEC-C Motif Domain Protein
B5S57_11265	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
B5S57_11270	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B5S57_11275	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B5S57_11280	COG0215	cysteine-tRNA ligase activity
B5S57_11285	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B5S57_11290	COG0632	four-way junction helicase activity
B5S57_11295	COG2255	four-way junction helicase activity
B5S57_11300	COG1271	oxidase subunit
B5S57_11305	COG1294	oxidase, subunit
B5S57_11310	COG4890	Cyd operon protein YbgT
B5S57_11315	COG3790	cyd operon protein YbgE
B5S57_11320	COG0824	Thioesterase
B5S57_11325	COG0811	peptide transport
B5S57_11345	COG2885	chlorophyll binding
B5S57_11350	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
B5S57_11360	COG2433	Pfam Transposase IS66
B5S57_11380	COG5002	protein histidine kinase activity
B5S57_11380	COG0784	Response regulator, receiver
B5S57_11395	COG0582	viral genome integration into host DNA
B5S57_11490	COG2404	hydrolase activity, acting on ester bonds
B5S57_11610	COG1403	HNH endonuclease
B5S57_11675	COG4626	Terminase
B5S57_11675	COG1802	Transcriptional regulator
B5S57_11690	COG0740	serine-type endopeptidase activity
B5S57_11820	COG5001	Diguanylate cyclase
B5S57_11820	COG3300	MHYT domain
B5S57_11845	COG1960	acyl-CoA dehydrogenase activity
B5S57_11850	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B5S57_11880	COG0247	lactate metabolic process
B5S57_11880	COG0277	FAD linked oxidase domain protein
B5S57_11895	COG2986	histidine ammonia-lyase
B5S57_11905	COG0010	Belongs to the arginase family
B5S57_11910	COG1228	amidohydrolase
B5S57_11925	COG3099	Belongs to the UPF0263 family
B5S57_11930	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B5S57_11940	COG0417	DNA replication proofreading
B5S57_11945	COG2197	response regulator
B5S57_11950	COG0322	excinuclease ABC activity
B5S57_11995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B5S57_11995	COG0072	phenylalanine-tRNA ligase activity
B5S57_12010	COG0500	methyltransferase
B5S57_12020	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B5S57_12025	COG5001	Diguanylate cyclase
B5S57_12030	COG0295	cytidine deaminase activity
B5S57_12035	COG1346	cytolysis
B5S57_12045	COG2925	Exonuclease
B5S57_12055	COG0702	epimerase
B5S57_12100	COG0210	DNA helicase
B5S57_12135	COG2801	Transposase and inactivated derivatives
B5S57_12145	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B5S57_12185	COG2994	toxin metabolic process
B5S57_12190	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
B5S57_12190	COG3064	Membrane
B5S57_12190	COG1073	alpha beta
B5S57_12200	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
B5S57_12215	COG2988	succinylglutamate desuccinylase activity
B5S57_12220	COG4139	cobalamin transport
B5S57_12245	COG0583	DNA-binding transcription factor activity
B5S57_12255	COG1451	nucleotide metabolic process
B5S57_12270	COG3063	Type IV pilus biogenesis stability protein PilW
B5S57_12295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B5S57_12310	COG3290	protein histidine kinase activity
B5S57_12315	COG4565	transcriptional regulatory protein
B5S57_12325	COG0784	Response regulator, receiver
B5S57_12325	COG0835	chemotaxis
B5S57_12340	COG3706	GGDEF domain
B5S57_12340	COG0745	RESPONSE REGULATOR receiver
B5S57_12365	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B5S57_12390	COG3501	Rhs element vgr protein
B5S57_12440	COG1181	Belongs to the D-alanine--D-alanine ligase family
B5S57_12460	COG1716	ATPase activity
B5S57_12485	COG4991	sh3 domain protein
B5S57_12485	COG3064	Membrane
B5S57_12485	COG0515	serine threonine protein kinase
B5S57_12530	COG2433	Pfam Transposase IS66
B5S57_12550	COG0251	oxidation-reduction process
B5S57_12560	COG1294	oxidase, subunit
B5S57_12580	COG3220	belongs to the UPF0276 family
B5S57_12605	COG0840	transmembrane signaling receptor activity
B5S57_12615	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B5S57_12620	COG2200	EAL domain
B5S57_12625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B5S57_12630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B5S57_12630	COG1263	PTS System
B5S57_12640	COG1621	beta-fructofuranosidase activity
B5S57_12645	COG0840	transmembrane signaling receptor activity
B5S57_12660	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
B5S57_12665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5S57_12675	COG0848	biopolymer transport protein
B5S57_12680	COG0811	peptide transport
B5S57_12685	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
B5S57_12690	COG3721	Heme iron utilization protein
B5S57_12695	COG0748	coenzyme F420 binding
B5S57_12700	COG4771	TonB-dependent receptor
B5S57_12700	COG1629	transport
B5S57_12705	COG1940	carbohydrate kinase activity
B5S57_12735	COG2989	Protein conserved in bacteria
B5S57_12740	COG3108	Peptidase M15
B5S57_12745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B5S57_12760	COG1846	Transcriptional regulator
B5S57_12765	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B5S57_12780	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
B5S57_12785	COG1448	Aminotransferase
B5S57_12790	COG3437	response regulator, receiver
B5S57_12790	COG2770	Histidine kinase
B5S57_12795	COG0840	transmembrane signaling receptor activity
B5S57_12800	COG0745	RESPONSE REGULATOR receiver
B5S57_12810	COG2198	Histidine kinase
B5S57_12810	COG0643	Histidine kinase
B5S57_12820	COG0835	chemotaxis
B5S57_12825	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B5S57_12830	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B5S57_12835	COG2201	protein-glutamate methylesterase activity
B5S57_12845	COG0017	Asparaginyl-tRNA synthetase
B5S57_12850	COG0840	transmembrane signaling receptor activity
B5S57_12855	COG0720	synthase
B5S57_12860	COG2356	endonuclease I
B5S57_12870	COG1760	l-serine dehydratase
B5S57_12875	COG0814	amino acid
B5S57_12880	COG0494	nUDIX hydrolase
B5S57_12885	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B5S57_12900	COG3106	COG3106 Predicted ATPase
B5S57_12905	COG3768	UPF0283 membrane protein
B5S57_12910	COG3283	Transcriptional regulator of aromatic amino acids metabolism
B5S57_12915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B5S57_12925	COG3706	GGDEF domain
B5S57_12935	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B5S57_12950	COG3344	reverse transcriptase
B5S57_12960	COG4191	Histidine kinase
B5S57_12960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5S57_12975	COG1278	Cold shock
B5S57_12980	COG3005	denitrification pathway
B5S57_12985	COG0243	molybdopterin cofactor binding
B5S57_12990	COG0513	Belongs to the DEAD box helicase family
B5S57_12995	COG2723	6-phospho-beta-galactosidase activity
B5S57_13000	COG1609	Transcriptional regulator
B5S57_13030	COG0443	Heat shock 70 kDa protein
B5S57_13070	COG1643	Atp-dependent helicase
B5S57_13080	COG0583	DNA-binding transcription factor activity
B5S57_13085	COG0477	Major facilitator Superfamily
B5S57_13100	COG0673	inositol 2-dehydrogenase activity
B5S57_13105	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B5S57_13110	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B5S57_13110	COG0517	IMP dehydrogenase activity
B5S57_13115	COG2176	DNA-directed DNA polymerase activity
B5S57_13125	COG3718	enzyme involved in inositol metabolism
B5S57_13130	COG3962	Belongs to the TPP enzyme family
B5S57_13135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B5S57_13160	COG0673	inositol 2-dehydrogenase activity
B5S57_13165	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B5S57_13205	COG1204	response to ionizing radiation
B5S57_13225	COG2433	Pfam Transposase IS66
B5S57_13235	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B5S57_13240	COG1280	lysine exporter protein (LysE YggA)
B5S57_13245	COG1115	amino acid carrier protein
B5S57_13255	COG2195	Cleaves the N-terminal amino acid of tripeptides
B5S57_13265	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
B5S57_13275	COG0625	glutathione transferase activity
B5S57_13305	COG0811	peptide transport
B5S57_13310	COG0811	peptide transport
B5S57_13315	COG0848	biopolymer transport protein
B5S57_13330	COG4667	esterase of the alpha-beta hydrolase superfamily
B5S57_13335	COG1793	dna ligase
B5S57_13360	COG0791	NLP P60 protein
B5S57_13365	COG0840	transmembrane signaling receptor activity
B5S57_13390	COG1763	Mo-molybdopterin cofactor biosynthetic process
B5S57_13395	COG0746	molybdenum cofactor guanylyltransferase activity
B5S57_13400	COG3842	ATPase activity
B5S57_13410	COG1840	ABC-type Fe3 transport system, periplasmic component
B5S57_13415	COG2271	Major facilitator Superfamily
B5S57_13425	COG2197	response regulator
B5S57_13430	COG0488	(ABC) transporter
B5S57_13435	COG0004	ammonium transporteR
B5S57_13440	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B5S57_13445	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B5S57_13450	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B5S57_13455	COG1177	transmembrane transport
B5S57_13460	COG1176	ABC-type spermidine putrescine transport system, permease component I
B5S57_13465	COG3842	ATPase activity
B5S57_13490	COG0589	response to stress
B5S57_13495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B5S57_13510	COG2217	Heavy metal translocating P-type atpase
B5S57_13520	COG2010	Cytochrome c
B5S57_13535	COG3278	Belongs to the heme-copper respiratory oxidase family
B5S57_13565	COG3120	sequence-specific DNA binding
B5S57_13570	COG1067	ATP-dependent peptidase activity
B5S57_13575	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B5S57_13600	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B5S57_13600	COG0116	Belongs to the methyltransferase superfamily
B5S57_13610	COG0167	dihydroorotate dehydrogenase activity
B5S57_13615	COG2902	Dehydrogenase
B5S57_13625	COG0308	aminopeptidase N
B5S57_13645	COG1956	GAF domain-containing protein
B5S57_13650	COG1132	(ABC) transporter
B5S57_13655	COG2995	paraquat-inducible protein a
B5S57_13660	COG3008	intermembrane lipid transfer
B5S57_13670	COG2996	Protein conserved in bacteria
B5S57_13690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B5S57_13705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B5S57_13705	COG1648	precorrin-2 dehydrogenase activity
B5S57_13710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5S57_13715	COG4597	amino acid ABC transporter
B5S57_13720	COG0765	amino acid transport
B5S57_13725	COG1126	abc transporter atp-binding protein
B5S57_13730	COG0670	Belongs to the BI1 family
B5S57_13735	COG2920	part of a sulfur-relay system
B5S57_13740	COG1254	Belongs to the acylphosphatase family
B5S57_13745	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B5S57_13785	COG0602	queuosine metabolic process
B5S57_13790	COG0561	phosphatase activity
B5S57_13810	COG2828	Protein conserved in bacteria
B5S57_13815	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B5S57_13820	COG0372	Belongs to the citrate synthase family
B5S57_13825	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B5S57_13855	COG0745	RESPONSE REGULATOR receiver
B5S57_13860	COG5002	protein histidine kinase activity
B5S57_13865	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B5S57_13870	COG1902	pentaerythritol trinitrate reductase activity
B5S57_13875	COG0583	DNA-binding transcription factor activity
B5S57_13885	COG1129	ABC transporter
B5S57_13915	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B5S57_13925	COG2207	Transcriptional regulator
B5S57_13930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B5S57_13930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B5S57_13930	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B5S57_13950	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
B5S57_13955	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
B5S57_13960	COG3051	citrate lyase alpha subunit
B5S57_13965	COG2301	Belongs to the HpcH HpaI aldolase family
B5S57_13970	COG3052	prosthetic group binding
B5S57_13975	COG4565	transcriptional regulatory protein
B5S57_13985	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
B5S57_13990	COG0511	ligase activity, forming carbon-carbon bonds
B5S57_13990	COG5016	pyruvate
B5S57_14005	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
B5S57_14025	COG0840	transmembrane signaling receptor activity
B5S57_14035	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B5S57_14040	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B5S57_14045	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B5S57_14075	COG0840	transmembrane signaling receptor activity
B5S57_14080	COG0019	diaminopimelate decarboxylase activity
B5S57_14100	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B5S57_14115	COG4181	ATPase activity
B5S57_14120	COG0534	Mate efflux family protein
B5S57_14125	COG0702	epimerase
B5S57_14135	COG2814	Major facilitator Superfamily
B5S57_14140	COG1187	pseudouridine synthase activity
B5S57_14145	COG1061	Type III restriction enzyme res subunit
B5S57_14160	COG2205	protein histidine kinase activity
B5S57_14180	COG0513	Belongs to the DEAD box helicase family
B5S57_14210	COG3313	Fe-S protein
B5S57_14220	COG4134	Bacterial extracellular solute-binding protein
B5S57_14225	COG4135	transport system, permease component
B5S57_14230	COG4136	ATPase activity
B5S57_14235	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B5S57_14250	COG0564	pseudouridine synthase activity
B5S57_14255	COG0733	neurotransmitter:sodium symporter activity
B5S57_14265	COG0626	cystathionine gamma-synthase activity
B5S57_14270	COG0519	Catalyzes the synthesis of GMP from XMP
B5S57_14285	COG1842	Phage shock protein A
B5S57_14290	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
B5S57_14300	COG4168	peptide transport system, permease
B5S57_14305	COG4171	peptide transport system, permease
B5S57_14315	COG4172	Belongs to the ABC transporter superfamily
B5S57_14330	COG1227	inorganic diphosphatase activity
B5S57_14340	COG0243	molybdopterin cofactor binding
B5S57_14345	COG3005	denitrification pathway
B5S57_14350	COG4459	periplasmic nitrate reductase
B5S57_14355	COG2116	formate transmembrane transporter activity
B5S57_14380	COG1434	Gram-negative-bacterium-type cell wall biogenesis
B5S57_14385	COG1435	thymidine kinase activity
B5S57_14390	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B5S57_14395	COG1801	Protein of unknown function DUF72
B5S57_14405	COG4106	trans-aconitate 2-methyltransferase activity
B5S57_14415	COG4067	protein conserved in archaea
B5S57_14415	COG0189	ligase activity
B5S57_14430	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
B5S57_14435	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
B5S57_14445	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B5S57_14450	COG1434	Gram-negative-bacterium-type cell wall biogenesis
B5S57_14455	COG0745	RESPONSE REGULATOR receiver
B5S57_14465	COG1609	Transcriptional regulator
B5S57_14470	COG3070	regulator of competence-specific genes
B5S57_14490	COG0297	glycogen (starch) synthase activity
B5S57_14495	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B5S57_14500	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B5S57_14510	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B5S57_14515	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
B5S57_14520	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
B5S57_14525	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B5S57_14530	COG0542	response to heat
B5S57_14535	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B5S57_14540	COG1278	Cold shock
B5S57_14550	COG1187	pseudouridine synthase activity
B5S57_14555	COG0140	phosphoribosyl-ATP diphosphatase activity
B5S57_14555	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B5S57_14560	COG0107	imidazoleglycerol-phosphate synthase activity
B5S57_14565	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B5S57_14570	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B5S57_14575	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B5S57_14575	COG0131	Imidazoleglycerol-phosphate dehydratase
B5S57_14580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B5S57_14585	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B5S57_14595	COG1757	Na H antiporter
B5S57_14600	COG2916	Histone family protein nucleoid-structuring protein H-NS
B5S57_14605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B5S57_14615	COG0482	sulfurtransferase activity
B5S57_14620	COG2915	High frequency lysogenization protein hflD homolog
B5S57_14625	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B5S57_14630	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B5S57_14640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5S57_14640	COG4191	Histidine kinase
B5S57_14655	COG3070	regulator of competence-specific genes
B5S57_14665	COG2431	L-lysine efflux transmembrane transporter activity
B5S57_14675	COG0076	glutamate decarboxylase activity
B5S57_14680	COG1737	Transcriptional regulator
B5S57_14690	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B5S57_14710	COG0281	malic enzyme
B5S57_14720	COG2949	membrane
B5S57_14735	COG3706	GGDEF domain
B5S57_14735	COG0745	RESPONSE REGULATOR receiver
B5S57_14740	COG0492	ferredoxin-NADP+ reductase activity
B5S57_14745	COG4988	ABC transporter
B5S57_14750	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B5S57_14765	COG1595	DNA-templated transcription, initiation
B5S57_14780	COG1187	pseudouridine synthase activity
B5S57_14785	COG0009	L-threonylcarbamoyladenylate synthase
B5S57_14790	COG0613	PHP domain protein
B5S57_14800	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B5S57_14805	COG0512	Glutamine amidotransferase of anthranilate synthase
B5S57_14810	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B5S57_14815	COG0135	phosphoribosylanthranilate isomerase activity
B5S57_14815	COG0134	indole-3-glycerol-phosphate synthase activity
B5S57_14820	COG0133	tryptophan synthase activity
B5S57_14850	COG1607	acyl-coa hydrolase
B5S57_14855	COG2350	Protein conserved in bacteria
B5S57_14865	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B5S57_14870	COG0583	DNA-binding transcription factor activity
B5S57_14885	COG2203	Gaf domain
B5S57_14885	COG2199	diguanylate cyclase activity
B5S57_14885	COG2200	EAL domain
B5S57_14895	COG1032	radical SAM domain protein
B5S57_14905	COG2268	Band 7 protein
B5S57_14915	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B5S57_14930	COG0300	oxidoreductase activity
B5S57_14940	COG0501	Belongs to the peptidase M48B family
B5S57_14950	COG1674	ftsk spoiiie
B5S57_14955	COG1522	sequence-specific DNA binding
B5S57_14960	COG0686	Belongs to the AlaDH PNT family
B5S57_14970	COG0583	DNA-binding transcription factor activity
B5S57_14985	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
B5S57_14990	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
B5S57_15000	COG0539	negative regulation of cytoplasmic translation
B5S57_15005	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B5S57_15010	COG1555	photosystem II stabilization
B5S57_15015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B5S57_15020	COG0776	regulation of translation
B5S57_15025	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B5S57_15040	COG0544	peptidyl-prolyl cis-trans isomerase activity
B5S57_15060	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B5S57_15065	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B5S57_15070	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B5S57_15080	COG1653	transport
B5S57_15085	COG2205	protein histidine kinase activity
B5S57_15090	COG0745	RESPONSE REGULATOR receiver
B5S57_15095	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
B5S57_15100	COG1760	l-serine dehydratase
B5S57_15110	COG0513	Belongs to the DEAD box helicase family
B5S57_15120	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B5S57_15135	COG4628	conserved protein (DUF2132)
B5S57_15160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B5S57_15165	COG0583	DNA-binding transcription factor activity
B5S57_15170	COG2951	lytic endotransglycosylase activity
B5S57_15175	COG3100	YcgL domain-containing protein
B5S57_15185	COG2894	cell division
B5S57_15195	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
B5S57_15200	COG0318	PFAM AMP-dependent synthetase and ligase
B5S57_15205	COG0596	Alpha beta hydrolase
B5S57_15220	COG1214	PFAM Peptidase M22, glycoprotease
B5S57_15225	COG1199	ATP-dependent helicase activity
B5S57_15235	COG0788	formyltetrahydrofolate deformylase activity
B5S57_15240	COG1902	pentaerythritol trinitrate reductase activity
B5S57_15240	COG0446	pyridine nucleotide-disulphide oxidoreductase
B5S57_15245	COG0616	signal peptide processing
B5S57_15250	COG0252	asparaginase activity
B5S57_15255	COG3139	Protein of unknown function (DUF1315)
B5S57_15265	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B5S57_15280	COG2226	methyltransferase
B5S57_15310	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B5S57_15320	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B5S57_15325	COG2832	Protein of unknown function (DUF454)
B5S57_15330	COG0745	RESPONSE REGULATOR receiver
B5S57_15335	COG0583	DNA-binding transcription factor activity
B5S57_15340	COG0778	Nitroreductase
B5S57_15345	COG1250	3-hydroxyacyl-CoA dehydrogenase
B5S57_15345	COG1024	Enoyl-CoA hydratase
B5S57_15350	COG0183	Belongs to the thiolase family
B5S57_15365	COG1595	DNA-templated transcription, initiation
B5S57_15375	COG2067	long-chain fatty acid transport protein
B5S57_15380	COG2067	long-chain fatty acid transport protein
B5S57_15385	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
B5S57_15390	COG2982	Protein involved in outer membrane biogenesis
B5S57_15395	COG0572	uridine kinase
B5S57_15400	COG0489	protein tyrosine kinase activity
B5S57_15405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B5S57_15405	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B5S57_15415	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
B5S57_15425	COG4109	DRTGG domain
B5S57_15430	COG2199	diguanylate cyclase activity
B5S57_15435	COG0314	molybdopterin synthase activity
B5S57_15440	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
B5S57_15450	COG0521	Mo-molybdopterin cofactor biosynthetic process
B5S57_15455	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B5S57_15460	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B5S57_15465	COG2198	Histidine kinase
B5S57_15470	COG2204	response regulator
B5S57_15475	COG0556	nucleotide-excision repair
B5S57_15490	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B5S57_15495	COG1028	Short-chain dehydrogenase reductase Sdr
B5S57_15500	COG1169	isochorismate synthase
B5S57_15505	COG1021	2,3-dihydroxybenzoate-AMP ligase
B5S57_15510	COG1535	isochorismatase
B5S57_15510	COG3433	isochorismatase activity
B5S57_15530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B5S57_15540	COG2382	esterase
B5S57_15545	COG4774	siderophore transport
B5S57_15545	COG1629	transport
B5S57_15555	COG4657	Part of a membrane complex involved in electron transport
B5S57_15560	COG2878	Part of a membrane complex involved in electron transport
B5S57_15565	COG4656	Part of a membrane complex involved in electron transport
B5S57_15570	COG4658	electron transport chain
B5S57_15585	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B5S57_15590	COG0346	lactoylglutathione lyase activity
B5S57_15600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B5S57_15605	COG2056	Na+-H+ antiporter family
B5S57_15610	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B5S57_15615	COG1286	toxin biosynthetic process
B5S57_15620	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
B5S57_15625	COG0285	dihydrofolate synthase activity
B5S57_15645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B5S57_15650	COG1263	PTS System
B5S57_15650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B5S57_15650	COG2190	(PTS) system
B5S57_15655	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B5S57_15660	COG1846	Transcriptional regulator
B5S57_15660	COG1940	carbohydrate kinase activity
B5S57_15665	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B5S57_15665	COG4651	solute:proton antiporter activity
B5S57_15670	COG0367	asparagine synthase
B5S57_15680	COG3104	oligopeptide transport
B5S57_15685	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B5S57_15695	COG0326	Molecular chaperone. Has ATPase activity
B5S57_15700	COG3710	Transcriptional regulator
B5S57_15715	COG0622	Phosphoesterase
B5S57_15720	COG1090	epimerase
B5S57_15725	COG3118	belongs to the thioredoxin family
B5S57_15730	COG0330	HflC and HflK could
B5S57_15740	COG0789	Transcriptional regulator
B5S57_15765	COG3115	cell septum assembly
B5S57_15770	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
B5S57_15775	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B5S57_15780	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B5S57_15785	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B5S57_15790	COG2190	(PTS) system
B5S57_15795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B5S57_15800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B5S57_15805	COG1702	phosphate starvation-inducible protein PhoH
B5S57_15815	COG4535	Mg2 and Co2 transporter CorC
B5S57_15820	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B5S57_15825	COG2888	peptidyl-tyrosine sulfation
B5S57_15830	COG0495	leucyl-tRNA aminoacylation
B5S57_15835	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
B5S57_15840	COG1466	dna polymerase III delta subunit
B5S57_15845	COG0799	negative regulation of ribosome biogenesis
B5S57_15850	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B5S57_15855	COG0768	penicillin binding
B5S57_15860	COG0772	Belongs to the SEDS family
B5S57_15865	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B5S57_15870	COG1686	Belongs to the peptidase S11 family
B5S57_15875	COG2921	Belongs to the UPF0250 family
B5S57_15880	COG0321	lipoyl(octanoyl) transferase activity
B5S57_15895	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B5S57_15915	COG1596	polysaccharide export
B5S57_15920	COG0489	protein tyrosine kinase activity
B5S57_15950	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
B5S57_15960	COG1045	serine acetyltransferase
B5S57_16000	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B5S57_16005	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B5S57_16010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B5S57_16015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B5S57_16020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B5S57_16055	COG2205	protein histidine kinase activity
B5S57_16060	COG0745	RESPONSE REGULATOR receiver
B5S57_16065	COG0366	Alpha amylase catalytic
B5S57_16070	COG1263	PTS System
B5S57_16070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B5S57_16085	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B5S57_16090	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B5S57_16095	COG2011	ABC-type metal ion transport system permease component
B5S57_16100	COG1464	Belongs to the NlpA lipoprotein family
B5S57_16105	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
B5S57_16125	COG3706	GGDEF domain
B5S57_16130	COG1611	Belongs to the LOG family
B5S57_16135	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B5S57_16145	COG2363	Small membrane protein
B5S57_16150	COG0583	DNA-binding transcription factor activity
B5S57_16155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B5S57_16155	COG0301	tRNA thio-modification
B5S57_16165	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B5S57_16175	COG0142	geranyltranstransferase activity
B5S57_16180	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B5S57_16185	COG0564	pseudouridine synthase activity
B5S57_16190	COG3098	single-species biofilm formation
B5S57_16220	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B5S57_16230	COG1720	tRNA m6t6A37 methyltransferase activity
B5S57_16235	COG0442	prolyl-tRNA aminoacylation
B5S57_16240	COG2979	Protein of unknown function (DUF533)
B5S57_16260	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B5S57_16260	COG0047	phosphoribosylformylglycinamidine synthase activity
B5S57_16265	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
B5S57_16270	COG0590	tRNA wobble adenosine to inosine editing
B5S57_16275	COG0583	DNA-binding transcription factor activity
B5S57_16285	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
B5S57_16290	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
B5S57_16320	COG0484	heat shock protein binding
B5S57_16325	COG0443	Heat shock 70 kDa protein
B5S57_16330	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B5S57_16335	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B5S57_16345	COG0497	DNA recombination
B5S57_16350	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B5S57_16355	COG2914	Belongs to the UPF0125 (RnfH) family
B5S57_16360	COG2867	negative regulation of translational initiation
B5S57_16375	COG0582	viral genome integration into host DNA
B5S57_16380	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
B5S57_16400	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
B5S57_16405	COG1715	Restriction endonuclease
B5S57_16420	COG2003	Belongs to the UPF0758 family
B5S57_16560	COG3964	amidohydrolase
B5S57_16575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B5S57_16575	COG3711	transcriptional antiterminator
B5S57_16580	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
B5S57_16600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5S57_16605	COG1115	amino acid carrier protein
B5S57_16610	COG1584	GPR1 FUN34 yaaH family protein
B5S57_16620	COG0351	phosphomethylpyrimidine kinase
B5S57_16625	COG0519	Catalyzes the synthesis of GMP from XMP
B5S57_16625	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B5S57_16630	COG0517	IMP dehydrogenase activity
B5S57_16630	COG0516	GMP reductase activity
B5S57_16645	COG1160	GTP binding
B5S57_16650	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B5S57_16655	COG2976	Protein conserved in bacteria
B5S57_16660	COG0124	histidyl-tRNA synthetase
B5S57_16665	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B5S57_16670	COG1426	Protein conserved in bacteria
B5S57_16685	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B5S57_16690	COG2975	iron-sulfur cluster assembly
B5S57_16695	COG0633	Ferredoxin
B5S57_16700	COG0443	Heat shock 70 kDa protein
B5S57_16710	COG0316	Belongs to the HesB IscA family
B5S57_16715	COG0822	iron-sulfur transferase activity
B5S57_16725	COG1959	2 iron, 2 sulfur cluster binding
B5S57_16730	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
B5S57_16735	COG0483	inositol monophosphate 1-phosphatase activity
B5S57_16740	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B5S57_16745	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B5S57_16750	COG1862	Preprotein translocase
B5S57_16760	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B5S57_16765	COG0517	IMP dehydrogenase activity
B5S57_16775	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B5S57_16780	COG0583	DNA-binding transcription factor activity
B5S57_16785	COG0450	alkyl hydroperoxide reductase
B5S57_16790	COG3142	Participates in the control of copper homeostasis
B5S57_16795	COG0704	Plays a role in the regulation of phosphate uptake
B5S57_16800	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B5S57_16805	COG0581	inorganic phosphate transmembrane transporter activity
B5S57_16815	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B5S57_16820	COG0248	Ppx GppA phosphatase
B5S57_16830	COG5002	protein histidine kinase activity
B5S57_16835	COG0745	RESPONSE REGULATOR receiver
B5S57_16850	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B5S57_16895	COG0542	response to heat
B5S57_16905	COG0564	pseudouridine synthase activity
B5S57_16910	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B5S57_16915	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B5S57_16920	COG1605	Chorismate mutase
B5S57_16920	COG0077	Prephenate dehydratase
B5S57_16925	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B5S57_16930	COG5001	Diguanylate cyclase
B5S57_16935	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
B5S57_16950	COG0488	(ABC) transporter
B5S57_16960	COG1605	Chorismate mutase
B5S57_16960	COG0287	Prephenate dehydrogenase
B5S57_16965	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B5S57_16970	COG3275	phosphorelay sensor kinase activity
B5S57_16975	COG3279	Response regulator of the LytR AlgR family
B5S57_16980	COG1472	Belongs to the glycosyl hydrolase 3 family
B5S57_16985	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B5S57_16990	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
B5S57_17005	COG1966	Carbon starvation protein
B5S57_17015	COG1047	Peptidyl-prolyl cis-trans
B5S57_17020	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B5S57_17030	COG0196	riboflavin kinase activity
B5S57_17035	COG0728	peptidoglycan biosynthetic process
B5S57_17045	COG0640	Transcriptional regulator
B5S57_17050	COG0583	DNA-binding transcription factor activity
B5S57_17055	COG1283	sodium-dependent phosphate transmembrane transporter activity
B5S57_17065	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B5S57_17100	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B5S57_17110	COG0730	response to heat
B5S57_17120	COG0494	nUDIX hydrolase
B5S57_17125	COG3066	DNA modification
B5S57_17130	COG0667	Aldo Keto reductase
B5S57_17140	COG2204	response regulator
B5S57_17145	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B5S57_17165	COG0513	Belongs to the DEAD box helicase family
B5S57_17190	COG3153	acetyltransferase
B5S57_17220	COG1846	Transcriptional regulator
B5S57_17240	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B5S57_17250	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B5S57_17255	COG0195	Participates in both transcription termination and antitermination
B5S57_17260	COG0779	Required for maturation of 30S ribosomal subunits
B5S57_17275	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B5S57_17280	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B5S57_17285	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B5S57_17290	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B5S57_17300	COG1534	Rna-binding protein
B5S57_17305	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B5S57_17315	COG2027	D-alanyl-D-alanine carboxypeptidase
B5S57_17320	COG2239	Acts as a magnesium transporter
B5S57_17330	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B5S57_17335	COG0739	heme binding
B5S57_17350	COG0316	Belongs to the HesB IscA family
B5S57_17355	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B5S57_17360	COG0628	permease
B5S57_17385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5S57_17390	COG0444	Belongs to the ABC transporter superfamily
B5S57_17395	COG4608	Belongs to the ABC transporter superfamily
B5S57_17405	COG2971	BadF BadG BcrA BcrD
B5S57_17420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B5S57_17435	COG1840	ABC-type Fe3 transport system, periplasmic component
B5S57_17440	COG0004	ammonium transporteR
B5S57_17455	COG3835	regulator
B5S57_17460	COG2610	gluconate transmembrane transporter activity
B5S57_17465	COG1929	Belongs to the glycerate kinase type-1 family
B5S57_17470	COG1049	propionate catabolic process, 2-methylcitrate cycle
B5S57_17475	COG1752	Esterase of the alpha-beta hydrolase superfamily
B5S57_17480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B5S57_17485	COG1643	Atp-dependent helicase
B5S57_17490	COG1489	DNA binding
B5S57_17495	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B5S57_17500	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B5S57_17510	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B5S57_17520	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B5S57_17530	COG0842	Transport permease protein
B5S57_17535	COG1131	(ABC) transporter
B5S57_17540	COG0659	secondary active sulfate transmembrane transporter activity
B5S57_17545	COG0288	reversible hydration of carbon dioxide
B5S57_17560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B5S57_17565	COG0508	dehydrogenase complex catalyzes the overall conversion of
B5S57_17570	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B5S57_17575	COG2186	Transcriptional regulator
B5S57_17580	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B5S57_17585	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B5S57_17590	COG4974	Belongs to the 'phage' integrase family
B5S57_17595	COG0716	FMN binding
B5S57_17605	COG0157	Belongs to the NadC ModD family
B5S57_17615	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B5S57_17620	COG1459	type II secretion system
B5S57_17630	COG0237	dephospho-CoA kinase activity
B5S57_17635	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
B5S57_17640	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
B5S57_17645	COG0335	large ribosomal subunit rRNA binding
B5S57_17665	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B5S57_17670	COG4137	Cytochrome C assembly protein
B5S57_17675	COG4536	flavin adenine dinucleotide binding
B5S57_17690	COG0612	Peptidase, M16
B5S57_17695	COG1238	metal cluster binding
B5S57_17700	COG1063	alcohol dehydrogenase
B5S57_17705	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
B5S57_17710	COG5016	pyruvate
B5S57_17710	COG0511	ligase activity, forming carbon-carbon bonds
B5S57_17715	COG3630	sodium ion export across plasma membrane
B5S57_17760	COG0527	aspartate kinase activity
B5S57_17765	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B5S57_17770	COG2137	regulation of response to DNA damage stimulus
B5S57_17775	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B5S57_17780	COG1546	Belongs to the CinA family
B5S57_17785	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B5S57_17790	COG4208	sulfate ABC transporter
B5S57_17800	COG4150	thiosulfate binding
B5S57_17810	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B5S57_17815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B5S57_17820	COG1388	LysM domain
B5S57_17820	COG4942	peptidase
B5S57_17825	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B5S57_17830	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B5S57_17835	COG0585	pseudouridine synthase activity
B5S57_17840	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B5S57_17845	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B5S57_17850	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B5S57_17855	COG1968	undecaprenyl-diphosphatase activity
B5S57_17860	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B5S57_17865	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B5S57_17890	COG1610	YqeY-like protein
B5S57_17895	COG0358	DNA primase activity
B5S57_17900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B5S57_17915	COG3550	peptidyl-serine autophosphorylation
B5S57_17935	COG0210	DNA helicase
B5S57_18005	COG4584	PFAM Integrase catalytic
B5S57_18010	COG1484	DNA-dependent DNA replication
B5S57_18135	COG2433	Pfam Transposase IS66
B5S57_18185	COG3501	Rhs element vgr protein
B5S57_18205	COG5492	domain, Protein
B5S57_18205	COG4932	domain protein
B5S57_18215	COG1349	DNA-binding transcription factor activity
B5S57_18220	COG0469	pyruvate kinase activity
B5S57_18225	COG3706	GGDEF domain
B5S57_18245	COG0668	transmembrane transport
B5S57_18250	COG0191	fructose-bisphosphate aldolase activity
B5S57_18260	COG0126	phosphoglycerate kinase activity
B5S57_18265	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B5S57_18270	COG4771	TonB-dependent receptor
B5S57_18275	COG0583	DNA-binding transcription factor activity
B5S57_18280	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B5S57_18285	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B5S57_18290	COG3091	SprT-like family
B5S57_18295	COG2356	endonuclease I
B5S57_18300	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B5S57_18310	COG1678	Uncharacterized ACR, COG1678
B5S57_18315	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B5S57_18330	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B5S57_18335	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B5S57_18340	COG0762	integral membrane protein
B5S57_18345	COG1872	DUF167
B5S57_18360	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B5S57_18365	COG2066	Belongs to the glutaminase family
B5S57_18370	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B5S57_18385	COG0741	lytic transglycosylase activity
B5S57_18435	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B5S57_18440	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B5S57_18445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B5S57_18450	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B5S57_18460	COG2967	ApaG domain
B5S57_18475	COG3610	response to peptide
B5S57_18480	COG2966	Psort location CytoplasmicMembrane, score
B5S57_18485	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B5S57_18490	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B5S57_18505	COG0142	geranyltranstransferase activity
B5S57_18510	COG0531	amino acid
B5S57_18540	COG0589	response to stress
B5S57_18560	COG2235	arginine
B5S57_18565	COG0312	modulator of DNA gyrase
B5S57_18570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B5S57_18575	COG3164	Protein of unknown function
B5S57_18580	COG1530	ribonuclease E activity
B5S57_18585	COG0424	maF-like protein
B5S57_18590	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
B5S57_18595	COG1792	Involved in formation and maintenance of cell shape
B5S57_18600	COG1077	Cell shape determining protein MreB Mrl
B5S57_18645	COG1459	type II secretion system
B5S57_18650	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B5S57_18660	COG3409	Peptidoglycan-binding domain 1 protein
B5S57_18660	COG3267	Type II secretory pathway component ExeA
B5S57_18685	COG2200	EAL domain
B5S57_18685	COG2199	diguanylate cyclase activity
B5S57_18690	COG0629	single-stranded DNA binding
B5S57_18705	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B5S57_18715	COG2239	Acts as a magnesium transporter
B5S57_18730	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B5S57_18735	COG0527	aspartate kinase activity
B5S57_18740	COG0646	methionine synthase
B5S57_18740	COG1410	methionine synthase
B5S57_18815	COG0175	sulfate reduction
B5S57_18820	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B5S57_18825	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B5S57_18845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B5S57_18850	COG0735	belongs to the Fur family
B5S57_18870	COG2433	Pfam Transposase IS66
B5S57_18875	COG0166	Belongs to the GPI family
B5S57_18880	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B5S57_18885	COG0305	Participates in initiation and elongation during chromosome replication
B5S57_18895	COG0359	binds to the 23S rRNA
B5S57_18905	COG2965	DNA replication, synthesis of RNA primer
B5S57_18910	COG0360	Binds together with S18 to 16S ribosomal RNA
B5S57_18915	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B5S57_18920	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B5S57_18925	COG0049	tRNA binding
B5S57_18940	COG2923	Belongs to the DsrF TusC family
B5S57_18945	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
B5S57_18950	COG2964	Protein conserved in bacteria
B5S57_18955	COG0545	Peptidyl-prolyl cis-trans isomerase
B5S57_18970	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
B5S57_18975	COG0330	HflC and HflK could
B5S57_18980	COG0330	HflC and HflK could
B5S57_18985	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B5S57_18990	COG1923	regulation of RNA biosynthetic process
B5S57_18995	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B5S57_19000	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B5S57_19010	COG0802	atpase or kinase
B5S57_19015	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B5S57_19065	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B5S57_19070	COG1162	GTPase activity
B5S57_19080	COG0490	domain, Protein
B5S57_19080	COG0471	metal ion transport
B5S57_19095	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B5S57_19100	COG4942	peptidase
B5S57_19120	COG2816	NAD+ diphosphatase activity
B5S57_19125	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
B5S57_19130	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B5S57_19135	COG0085	RNA polymerase activity
B5S57_19140	COG0222	ribosome binding
B5S57_19145	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B5S57_19150	COG0081	regulation of translation
B5S57_19160	COG0250	Participates in transcription elongation, termination and antitermination
B5S57_19165	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B5S57_19170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B5S57_19195	COG1072	(Pantothenic acid kinase))
B5S57_19200	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B5S57_19200	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B5S57_19205	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B5S57_19215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B5S57_19260	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B5S57_19270	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B5S57_19275	COG3118	belongs to the thioredoxin family
B5S57_19285	COG0248	Ppx GppA phosphatase
B5S57_19290	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B5S57_19295	COG0194	GDP metabolic process
B5S57_19300	COG1758	RNA polymerase activity
B5S57_19305	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B5S57_19310	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B5S57_19315	COG2233	PERMEase
B5S57_19325	COG0745	RESPONSE REGULATOR receiver
B5S57_19350	COG0583	DNA-binding transcription factor activity
B5S57_19370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B5S57_19375	COG2183	response to ionizing radiation
B5S57_19385	COG0596	Alpha beta hydrolase
B5S57_19390	COG1040	competence protein
B5S57_19395	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B5S57_19395	COG0316	Belongs to the HesB IscA family
B5S57_19400	COG0494	nUDIX hydrolase
B5S57_19405	COG1218	3'(2'),5'-bisphosphate nucleotidase
B5S57_19415	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
B5S57_19420	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
B5S57_19425	COG3156	type II secretion system protein K
B5S57_19430	COG4795	General secretion pathway protein
B5S57_19435	COG2165	general secretion pathway protein
B5S57_19440	COG2165	general secretion pathway protein
B5S57_19445	COG2165	general secretion pathway protein
B5S57_19450	COG1459	type II secretion system
B5S57_19455	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B5S57_19465	COG3031	protein transport across the cell outer membrane
B5S57_19470	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B5S57_19475	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B5S57_19480	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
B5S57_19490	COG0456	acetyltransferase
B5S57_19495	COG1490	D-aminoacyl-tRNA deacylase activity
B5S57_19510	COG0174	glutamine synthetase
B5S57_19520	COG3852	Histidine kinase
B5S57_19530	COG5001	Diguanylate cyclase
B5S57_19530	COG3300	MHYT domain
B5S57_19535	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B5S57_19610	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B5S57_19655	COG3550	peptidyl-serine autophosphorylation
B5S57_19695	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B5S57_19730	COG3250	beta-galactosidase activity
B5S57_19750	COG0534	Mate efflux family protein
B5S57_19765	COG2937	Belongs to the GPAT DAPAT family
B5S57_19775	COG3161	chorismate lyase activity
B5S57_19780	COG1580	Controls the rotational direction of flagella during chemotaxis
B5S57_19785	COG0705	Rhomboid family
B5S57_19795	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B5S57_19800	COG2177	Part of the ABC transporter FtsEX involved in
B5S57_19805	COG2884	Cell division ATP-binding protein ftsE
B5S57_19810	COG0552	protein localization to endoplasmic reticulum
B5S57_19815	COG0742	ribosomal rna small subunit methyltransferase
B5S57_19825	COG2095	MarC family integral membrane protein
B5S57_19860	COG2433	Pfam Transposase IS66
B5S57_19870	COG2095	MarC family integral membrane protein
B5S57_19895	COG0783	Belongs to the Dps family
B5S57_19900	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
B5S57_19905	COG1280	lysine exporter protein (LysE YggA)
B5S57_19910	COG2267	carboxylic ester hydrolase activity
B5S57_19915	COG0561	phosphatase activity
B5S57_19930	COG1011	Hydrolase
B5S57_19935	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B5S57_19950	COG0019	diaminopimelate decarboxylase activity
B5S57_19965	COG3072	Adenylate cyclase
B5S57_19975	COG1587	Uroporphyrinogen-III synthase
B5S57_19980	COG2959	enzyme of heme biosynthesis
B5S57_19985	COG3071	HemY protein
B5S57_20020	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B5S57_20030	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B5S57_20035	COG0408	coproporphyrinogen oxidase activity
B5S57_20040	COG0009	L-threonylcarbamoyladenylate synthase
B5S57_20045	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B5S57_20050	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B5S57_20055	COG0551	DNA topoisomerase type I activity
B5S57_20080	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B5S57_20090	COG2801	Transposase and inactivated derivatives
B5S57_20125	COG0210	DNA helicase
B5S57_20155	COG2922	Belongs to the Smg family
B5S57_20160	COG0758	DNA mediated transformation
B5S57_20165	COG1652	LysM domain
B5S57_20170	COG0242	peptide deformylase activity
B5S57_20175	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B5S57_20180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B5S57_20180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B5S57_20185	COG0569	domain protein
B5S57_20190	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B5S57_20200	COG1272	protein, Hemolysin III
B5S57_20205	COG3084	Protein conserved in bacteria
B5S57_20220	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B5S57_20225	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B5S57_20235	COG0606	chelatase, subunit chli