locus-tag	class	description
VAA_00002	COG2197	response regulator
VAA_00004	COG3081	Nucleoid-associated protein
VAA_00015	COG2801	Transposase and inactivated derivatives
VAA_00021	COG0500	methyltransferase
VAA_00047	COG1072	(Pantothenic acid kinase))
VAA_00048	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
VAA_00048	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
VAA_00049	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VAA_00051	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAA_00082	COG5002	protein histidine kinase activity
VAA_00082	COG0784	Response regulator, receiver
VAA_00084	COG0582	viral genome integration into host DNA
VAA_00093	COG0724	RNA recognition motif
VAA_00113	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VAA_00114	COG0802	atpase or kinase
VAA_00116	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VAA_00117	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VAA_00118	COG1923	regulation of RNA biosynthetic process
VAA_00119	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VAA_00120	COG0330	HflC and HflK could
VAA_00121	COG0330	HflC and HflK could
VAA_00122	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VAA_00125	COG0545	Peptidyl-prolyl cis-trans isomerase
VAA_00126	COG2964	Protein conserved in bacteria
VAA_00127	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VAA_00128	COG2923	Belongs to the DsrF TusC family
VAA_00131	COG0049	tRNA binding
VAA_00132	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VAA_00134	COG1204	response to ionizing radiation
VAA_00141	COG3550	peptidyl-serine autophosphorylation
VAA_00150	COG0737	Belongs to the 5'-nucleotidase family
VAA_00152	COG3313	Fe-S protein
VAA_00154	COG4134	Bacterial extracellular solute-binding protein
VAA_00155	COG4135	transport system, permease component
VAA_00156	COG4136	ATPase activity
VAA_00157	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VAA_00173	COG5492	domain, Protein
VAA_00173	COG4932	domain protein
VAA_00176	COG1349	DNA-binding transcription factor activity
VAA_00177	COG0469	pyruvate kinase activity
VAA_00179	COG3706	GGDEF domain
VAA_00183	COG0668	transmembrane transport
VAA_00184	COG0191	fructose-bisphosphate aldolase activity
VAA_00185	COG0126	phosphoglycerate kinase activity
VAA_00186	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VAA_00188	COG4771	TonB-dependent receptor
VAA_00189	COG0583	DNA-binding transcription factor activity
VAA_00205	COG0352	thiamine-phosphate diphosphorylase activity
VAA_00207	COG2104	thiamine diphosphate biosynthetic process
VAA_00209	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VAA_00210	COG0006	proline dipeptidase activity
VAA_00210	COG0006	proline dipeptidase activity
VAA_00215	COG3040	lipid binding
VAA_00239	COG2084	Dehydrogenase
VAA_00240	COG0814	amino acid
VAA_00247	COG0583	DNA-binding transcription factor activity
VAA_00248	COG2910	NAD(P)H-binding
VAA_00250	COG3304	Inner membrane component domain
VAA_00253	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VAA_00254	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
VAA_00256	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VAA_00257	COG0360	Binds together with S18 to 16S ribosomal RNA
VAA_00258	COG2965	DNA replication, synthesis of RNA primer
VAA_00260	COG0359	binds to the 23S rRNA
VAA_00262	COG0305	Participates in initiation and elongation during chromosome replication
VAA_00263	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VAA_00264	COG0166	Belongs to the GPI family
VAA_00266	COG0735	belongs to the Fur family
VAA_00267	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VAA_00271	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VAA_00272	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VAA_00273	COG0175	sulfate reduction
VAA_00278	COG1484	DNA-dependent DNA replication
VAA_00279	COG4584	PFAM Integrase catalytic
VAA_00297	COG3501	Rhs element vgr protein
VAA_00312	COG2801	Transposase and inactivated derivatives
VAA_00313	COG2963	transposase activity
VAA_00325	COG0023	Translation Initiation Factor
VAA_00329	COG1181	Belongs to the D-alanine--D-alanine ligase family
VAA_00331	COG0045	succinate-CoA ligase (ADP-forming) activity
VAA_00331	COG1042	CoA-binding domain protein
VAA_00331	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VAA_00332	COG0583	DNA-binding transcription factor activity
VAA_00334	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VAA_00335	COG1162	GTPase activity
VAA_00338	COG0471	metal ion transport
VAA_00338	COG0490	domain, Protein
VAA_00342	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VAA_00344	COG4942	peptidase
VAA_00348	COG2816	NAD+ diphosphatase activity
VAA_00349	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VAA_00350	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VAA_00351	COG0085	RNA polymerase activity
VAA_00352	COG0222	ribosome binding
VAA_00353	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VAA_00354	COG0081	regulation of translation
VAA_00356	COG0250	Participates in transcription elongation, termination and antitermination
VAA_00357	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VAA_00361	COG2194	sulfuric ester hydrolase activity
VAA_00362	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VAA_00367	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VAA_00369	COG0730	response to heat
VAA_00371	COG0494	nUDIX hydrolase
VAA_00372	COG3066	DNA modification
VAA_00374	COG0667	Aldo Keto reductase
VAA_00376	COG2204	response regulator
VAA_00377	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VAA_00378	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VAA_00381	COG0513	Belongs to the DEAD box helicase family
VAA_00386	COG3153	acetyltransferase
VAA_00403	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VAA_00405	COG1283	sodium-dependent phosphate transmembrane transporter activity
VAA_00406	COG0583	DNA-binding transcription factor activity
VAA_00407	COG0640	Transcriptional regulator
VAA_00409	COG0728	peptidoglycan biosynthetic process
VAA_00410	COG0196	riboflavin kinase activity
VAA_00412	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VAA_00414	COG1047	Peptidyl-prolyl cis-trans
VAA_00416	COG1966	Carbon starvation protein
VAA_00419	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VAA_00420	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VAA_00421	COG1472	Belongs to the glycosyl hydrolase 3 family
VAA_00423	COG3275	phosphorelay sensor kinase activity
VAA_00424	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VAA_00425	COG1605	Chorismate mutase
VAA_00425	COG0287	Prephenate dehydrogenase
VAA_00427	COG0488	(ABC) transporter
VAA_00430	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VAA_00431	COG5001	Diguanylate cyclase
VAA_00432	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VAA_00433	COG0077	Prephenate dehydratase
VAA_00433	COG1605	Chorismate mutase
VAA_00434	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VAA_00437	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAA_00438	COG0564	pseudouridine synthase activity
VAA_00440	COG0542	response to heat
VAA_00445	COG2095	MarC family integral membrane protein
VAA_00447	COG0742	ribosomal rna small subunit methyltransferase
VAA_00448	COG0552	protein localization to endoplasmic reticulum
VAA_00449	COG2884	Cell division ATP-binding protein ftsE
VAA_00450	COG2177	Part of the ABC transporter FtsEX involved in
VAA_00451	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VAA_00454	COG0705	Rhomboid family
VAA_00455	COG1580	Controls the rotational direction of flagella during chemotaxis
VAA_00456	COG3161	chorismate lyase activity
VAA_00458	COG2937	Belongs to the GPAT DAPAT family
VAA_00461	COG0534	Mate efflux family protein
VAA_00466	COG3250	beta-galactosidase activity
VAA_00474	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
VAA_00481	COG3550	peptidyl-serine autophosphorylation
VAA_00490	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VAA_00494	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAA_00495	COG1115	amino acid carrier protein
VAA_00497	COG1584	GPR1 FUN34 yaaH family protein
VAA_00499	COG0351	phosphomethylpyrimidine kinase
VAA_00500	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VAA_00500	COG0519	Catalyzes the synthesis of GMP from XMP
VAA_00501	COG0516	GMP reductase activity
VAA_00501	COG0517	IMP dehydrogenase activity
VAA_00504	COG1160	GTP binding
VAA_00505	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAA_00506	COG2976	Protein conserved in bacteria
VAA_00507	COG0124	histidyl-tRNA synthetase
VAA_00508	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VAA_00509	COG1426	Protein conserved in bacteria
VAA_00512	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VAA_00513	COG2975	iron-sulfur cluster assembly
VAA_00514	COG0633	Ferredoxin
VAA_00515	COG0443	Heat shock 70 kDa protein
VAA_00517	COG0316	Belongs to the HesB IscA family
VAA_00518	COG0822	iron-sulfur transferase activity
VAA_00521	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
VAA_00522	COG0483	inositol monophosphate 1-phosphatase activity
VAA_00523	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VAA_00524	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VAA_00525	COG1862	Preprotein translocase
VAA_00527	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VAA_00528	COG0517	IMP dehydrogenase activity
VAA_00531	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VAA_00532	COG0583	DNA-binding transcription factor activity
VAA_00533	COG0450	alkyl hydroperoxide reductase
VAA_00534	COG3142	Participates in the control of copper homeostasis
VAA_00535	COG0704	Plays a role in the regulation of phosphate uptake
VAA_00536	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VAA_00537	COG0581	inorganic phosphate transmembrane transporter activity
VAA_00539	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VAA_00540	COG0248	Ppx GppA phosphatase
VAA_00542	COG5002	protein histidine kinase activity
VAA_00543	COG0745	RESPONSE REGULATOR receiver
VAA_00546	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VAA_00549	COG1522	sequence-specific DNA binding
VAA_00550	COG0742	ribosomal rna small subunit methyltransferase
VAA_00552	COG0697	spore germination
VAA_00553	COG0589	response to stress
VAA_00554	COG1528	Iron-storage protein
VAA_00557	COG2081	HI0933 family
VAA_00559	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAA_00560	COG1129	ABC transporter
VAA_00561	COG1879	ABC-type sugar transport system periplasmic component
VAA_00563	COG1069	ribulokinase activity
VAA_00565	COG2160	L-arabinose isomerase activity
VAA_00569	COG1322	Protein conserved in bacteria
VAA_00572	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VAA_00574	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VAA_00575	COG0805	protein transport
VAA_00576	COG0084	hydrolase, TatD family'
VAA_00578	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VAA_00578	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VAA_00579	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VAA_00584	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VAA_00585	COG0583	DNA-binding transcription factor activity
VAA_00587	COG2960	long-chain fatty acid transporting porin activity
VAA_00588	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VAA_00589	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAA_00590	COG1309	transcriptional regulator
VAA_00597	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAA_00611	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VAA_00613	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
VAA_00614	COG3118	belongs to the thioredoxin family
VAA_00616	COG0248	Ppx GppA phosphatase
VAA_00617	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VAA_00618	COG0194	GDP metabolic process
VAA_00619	COG1758	RNA polymerase activity
VAA_00620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VAA_00621	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VAA_00622	COG2233	PERMEase
VAA_00624	COG0745	RESPONSE REGULATOR receiver
VAA_00629	COG0583	DNA-binding transcription factor activity
VAA_00634	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VAA_00635	COG2183	response to ionizing radiation
VAA_00638	COG0596	Alpha beta hydrolase
VAA_00639	COG1040	competence protein
VAA_00640	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VAA_00640	COG0316	Belongs to the HesB IscA family
VAA_00641	COG0494	nUDIX hydrolase
VAA_00642	COG1218	3'(2'),5'-bisphosphate nucleotidase
VAA_00644	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VAA_00645	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VAA_00646	COG3156	type II secretion system protein K
VAA_00647	COG4795	General secretion pathway protein
VAA_00648	COG2165	general secretion pathway protein
VAA_00649	COG2165	general secretion pathway protein
VAA_00650	COG2165	general secretion pathway protein
VAA_00651	COG1459	type II secretion system
VAA_00652	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VAA_00654	COG3031	protein transport across the cell outer membrane
VAA_00655	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VAA_00656	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VAA_00658	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VAA_00660	COG1490	D-aminoacyl-tRNA deacylase activity
VAA_00663	COG0174	glutamine synthetase
VAA_00666	COG3852	Histidine kinase
VAA_00669	COG5001	Diguanylate cyclase
VAA_00669	COG3300	MHYT domain
VAA_00670	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VAA_00671	COG0210	DNA helicase
VAA_00675	COG3550	peptidyl-serine autophosphorylation
VAA_00677	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VAA_00678	COG0358	DNA primase activity
VAA_00679	COG1610	YqeY-like protein
VAA_00686	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VAA_00687	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VAA_00688	COG1968	undecaprenyl-diphosphatase activity
VAA_00689	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VAA_00690	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VAA_00691	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VAA_00692	COG0585	pseudouridine synthase activity
VAA_00693	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VAA_00694	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VAA_00695	COG1388	LysM domain
VAA_00695	COG4942	peptidase
VAA_00696	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VAA_00697	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VAA_00699	COG4150	thiosulfate binding
VAA_00701	COG4208	sulfate ABC transporter
VAA_00702	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
VAA_00703	COG1546	Belongs to the CinA family
VAA_00704	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VAA_00705	COG2137	regulation of response to DNA damage stimulus
VAA_00706	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VAA_00707	COG0527	aspartate kinase activity
VAA_00709	COG3630	sodium ion export across plasma membrane
VAA_00710	COG5016	pyruvate
VAA_00710	COG0511	ligase activity, forming carbon-carbon bonds
VAA_00711	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VAA_00712	COG1063	alcohol dehydrogenase
VAA_00713	COG1238	metal cluster binding
VAA_00714	COG0612	Peptidase, M16
VAA_00718	COG4536	flavin adenine dinucleotide binding
VAA_00719	COG4137	Cytochrome C assembly protein
VAA_00720	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VAA_00724	COG0335	large ribosomal subunit rRNA binding
VAA_00725	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VAA_00726	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VAA_00727	COG0237	dephospho-CoA kinase activity
VAA_00729	COG1459	type II secretion system
VAA_00731	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VAA_00733	COG0157	Belongs to the NadC ModD family
VAA_00735	COG0716	FMN binding
VAA_00736	COG4974	Belongs to the 'phage' integrase family
VAA_00737	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VAA_00738	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VAA_00739	COG2186	Transcriptional regulator
VAA_00740	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VAA_00741	COG0508	dehydrogenase complex catalyzes the overall conversion of
VAA_00742	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VAA_00745	COG0288	reversible hydration of carbon dioxide
VAA_00746	COG0659	secondary active sulfate transmembrane transporter activity
VAA_00747	COG1131	(ABC) transporter
VAA_00748	COG0842	Transport permease protein
VAA_00750	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VAA_00752	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VAA_00754	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VAA_00755	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VAA_00756	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VAA_00757	COG1489	DNA binding
VAA_00758	COG1643	Atp-dependent helicase
VAA_00759	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VAA_00760	COG1752	Esterase of the alpha-beta hydrolase superfamily
VAA_00761	COG1049	propionate catabolic process, 2-methylcitrate cycle
VAA_00762	COG1929	Belongs to the glycerate kinase type-1 family
VAA_00763	COG2610	gluconate transmembrane transporter activity
VAA_00764	COG3835	regulator
VAA_00767	COG0004	ammonium transporteR
VAA_00768	COG1840	ABC-type Fe3 transport system, periplasmic component
VAA_00771	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VAA_00774	COG2971	BadF BadG BcrA BcrD
VAA_00776	COG4608	Belongs to the ABC transporter superfamily
VAA_00777	COG0444	Belongs to the ABC transporter superfamily
VAA_00778	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAA_00784	COG0628	permease
VAA_00785	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VAA_00789	COG0739	heme binding
VAA_00790	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VAA_00792	COG2239	Acts as a magnesium transporter
VAA_00793	COG2027	D-alanyl-D-alanine carboxypeptidase
VAA_00795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VAA_00796	COG1534	Rna-binding protein
VAA_00798	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VAA_00799	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VAA_00800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VAA_00801	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VAA_00802	COG0779	Required for maturation of 30S ribosomal subunits
VAA_00803	COG0195	Participates in both transcription termination and antitermination
VAA_00804	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VAA_00806	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VAA_00810	COG1846	Transcriptional regulator
VAA_00815	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
VAA_00816	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VAA_00817	COG1739	Uncharacterized protein family UPF0029
VAA_00819	COG0183	Belongs to the thiolase family
VAA_00820	COG0583	DNA-binding transcription factor activity
VAA_00822	COG2814	Major facilitator Superfamily
VAA_00824	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VAA_00825	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VAA_00826	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VAA_00827	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VAA_00828	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VAA_00829	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VAA_00831	COG0356	it plays a direct role in the translocation of protons across the membrane
VAA_00832	COG3312	ion transport
VAA_00833	COG1475	DNA binding
VAA_00834	COG1192	Involved in chromosome partitioning
VAA_00836	COG0445	tRNA wobble uridine modification
VAA_00837	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VAA_00839	COG0706	membrane insertase activity
VAA_00840	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
VAA_00843	COG1126	abc transporter atp-binding protein
VAA_00847	COG0592	DNA-directed DNA polymerase activity
VAA_00848	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VAA_00849	COG0187	DNA topoisomerase II activity
VAA_00852	COG0071	Belongs to the small heat shock protein (HSP20) family
VAA_00853	COG3977	Valine--pyruvate aminotransferase
VAA_00855	COG0752	glycyl-tRNA synthetase alpha subunit
VAA_00857	COG2119	membrane
VAA_00864	COG0604	alcohol dehydrogenase
VAA_00866	COG0129	dihydroxy-acid dehydratase activity
VAA_00867	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VAA_00869	COG3978	acetolactate synthase activity
VAA_00872	COG0606	chelatase, subunit chli
VAA_00886	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VAA_00887	COG5001	Diguanylate cyclase
VAA_00887	COG3300	MHYT domain
VAA_00892	COG0010	Belongs to the arginase family
VAA_00893	COG1166	arginine decarboxylase activity
VAA_00896	COG4176	ABC-type proline glycine betaine transport system permease component
VAA_00897	COG2113	Glycine betaine
VAA_00901	COG2239	Acts as a magnesium transporter
VAA_00902	COG0527	aspartate kinase activity
VAA_00903	COG0662	Cupin 2, conserved barrel domain protein
VAA_00904	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VAA_00905	COG0456	acetyltransferase
VAA_00907	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VAA_00917	COG0366	Alpha amylase catalytic
VAA_00921	COG0714	Associated with various cellular activities
VAA_00925	COG2304	oxidoreductase activity
VAA_00928	COG3706	GGDEF domain
VAA_00930	COG1403	HNH endonuclease
VAA_00931	COG3530	Putative quorum-sensing-regulated virulence factor
VAA_00932	COG1368	sulfuric ester hydrolase activity
VAA_00934	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VAA_00935	COG1063	alcohol dehydrogenase
VAA_00936	COG0156	8-amino-7-oxononanoate synthase activity
VAA_00938	COG0346	lactoylglutathione lyase activity
VAA_00941	COG2197	response regulator
VAA_00942	COG3851	Histidine kinase
VAA_00943	COG2271	Major facilitator Superfamily
VAA_00946	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VAA_00950	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VAA_00951	COG0640	Transcriptional regulator
VAA_00952	COG0798	PFAM Bile acid sodium symporter
VAA_00953	COG0640	Transcriptional regulator
VAA_00954	COG0659	secondary active sulfate transmembrane transporter activity
VAA_00955	COG0589	response to stress
VAA_00958	COG0516	GMP reductase activity
VAA_00959	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VAA_00964	COG1278	Cold shock
VAA_00965	COG4681	YaeQ
VAA_00966	COG1017	nitric oxide dioxygenase activity
VAA_00966	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VAA_00967	COG3604	Transcriptional regulator
VAA_00970	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VAA_00971	COG3217	Mosc domain protein beta barrel domain protein
VAA_00971	COG0633	Ferredoxin
VAA_00973	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VAA_00974	COG2354	Protein conserved in bacteria
VAA_00976	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VAA_00982	COG1162	GTPase activity
VAA_00984	COG2226	methyltransferase
VAA_00989	COG2249	NAD(P)H dehydrogenase (quinone) activity
VAA_00990	COG0656	L-ascorbic acid biosynthetic process
VAA_00994	COG1566	PFAM secretion protein HlyD family protein
VAA_00999	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VAA_01001	COG0404	The glycine cleavage system catalyzes the degradation of glycine
VAA_01003	COG0612	Peptidase, M16
VAA_01005	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VAA_01005	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
VAA_01005	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VAA_01006	COG1105	Belongs to the carbohydrate kinase PfkB family
VAA_01007	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAA_01007	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAA_01008	COG1609	Transcriptional regulator
VAA_01009	COG0420	3'-5' exonuclease activity
VAA_01010	COG0419	ATPase involved in DNA repair
VAA_01011	COG2205	protein histidine kinase activity
VAA_01011	COG0784	Response regulator, receiver
VAA_01012	COG0156	8-amino-7-oxononanoate synthase activity
VAA_01014	COG0038	chloride channel
VAA_01015	COG0523	cobalamin synthesis protein
VAA_01016	COG1136	(ABC) transporter
VAA_01018	COG1136	(ABC) transporter
VAA_01018	COG0577	efflux transmembrane transporter activity
VAA_01021	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
VAA_01028	COG3730	PTS system glucitol sorbitol-specific
VAA_01031	COG1028	Short-chain dehydrogenase reductase Sdr
VAA_01032	COG1349	DNA-binding transcription factor activity
VAA_01033	COG3730	PTS system glucitol sorbitol-specific
VAA_01036	COG3842	ATPase activity
VAA_01039	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VAA_01041	COG2182	Extracellular solute-binding protein
VAA_01042	COG1175	transmembrane transport
VAA_01043	COG3833	ABC-type maltose transport systems, permease component
VAA_01049	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VAA_01050	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VAA_01052	COG3005	denitrification pathway
VAA_01054	COG0243	molybdopterin cofactor binding
VAA_01056	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VAA_01058	COG3850	Histidine kinase
VAA_01059	COG2197	response regulator
VAA_01060	COG3069	C4-dicarboxylate transmembrane transporter activity
VAA_01064	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VAA_01066	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
VAA_01067	COG0513	Belongs to the DEAD box helicase family
VAA_01068	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VAA_01080	COG3115	cell septum assembly
VAA_01081	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VAA_01082	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VAA_01083	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAA_01084	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VAA_01085	COG2190	(PTS) system
VAA_01086	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAA_01087	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VAA_01088	COG1702	phosphate starvation-inducible protein PhoH
VAA_01090	COG4535	Mg2 and Co2 transporter CorC
VAA_01091	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VAA_01092	COG2888	peptidyl-tyrosine sulfation
VAA_01093	COG0495	leucyl-tRNA aminoacylation
VAA_01094	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VAA_01095	COG1466	dna polymerase III delta subunit
VAA_01096	COG0799	negative regulation of ribosome biogenesis
VAA_01097	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VAA_01098	COG0768	penicillin binding
VAA_01099	COG0772	Belongs to the SEDS family
VAA_01100	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VAA_01101	COG1686	Belongs to the peptidase S11 family
VAA_01102	COG2921	Belongs to the UPF0250 family
VAA_01103	COG0321	lipoyl(octanoyl) transferase activity
VAA_01106	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VAA_01111	COG1596	polysaccharide export
VAA_01118	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
VAA_01120	COG1045	serine acetyltransferase
VAA_01128	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VAA_01129	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VAA_01132	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VAA_01133	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VAA_01135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAA_01138	COG2205	protein histidine kinase activity
VAA_01139	COG0745	RESPONSE REGULATOR receiver
VAA_01140	COG0366	Alpha amylase catalytic
VAA_01141	COG0366	Alpha amylase catalytic
VAA_01142	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VAA_01142	COG1263	PTS System
VAA_01145	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VAA_01146	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VAA_01147	COG2011	ABC-type metal ion transport system permease component
VAA_01149	COG1464	Belongs to the NlpA lipoprotein family
VAA_01150	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VAA_01154	COG3706	GGDEF domain
VAA_01155	COG1611	Belongs to the LOG family
VAA_01156	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VAA_01158	COG2363	Small membrane protein
VAA_01159	COG0583	DNA-binding transcription factor activity
VAA_01160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VAA_01160	COG0301	tRNA thio-modification
VAA_01161	COG1360	Flagellar Motor Protein
VAA_01161	COG1360	Flagellar Motor Protein
VAA_01162	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VAA_01165	COG0142	geranyltranstransferase activity
VAA_01166	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VAA_01167	COG0564	pseudouridine synthase activity
VAA_01168	COG3098	single-species biofilm formation
VAA_01173	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VAA_01175	COG1720	tRNA m6t6A37 methyltransferase activity
VAA_01176	COG0442	prolyl-tRNA aminoacylation
VAA_01177	COG2979	Protein of unknown function (DUF533)
VAA_01182	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VAA_01182	COG0047	phosphoribosylformylglycinamidine synthase activity
VAA_01183	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VAA_01185	COG0590	tRNA wobble adenosine to inosine editing
VAA_01188	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
VAA_01190	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VAA_01196	COG0484	heat shock protein binding
VAA_01197	COG0443	Heat shock 70 kDa protein
VAA_01198	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VAA_01199	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VAA_01203	COG0497	DNA recombination
VAA_01204	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAA_01205	COG2914	Belongs to the UPF0125 (RnfH) family
VAA_01206	COG2867	negative regulation of translational initiation
VAA_01208	COG0582	viral genome integration into host DNA
VAA_01209	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VAA_01213	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
VAA_01214	COG1715	Restriction endonuclease
VAA_01217	COG2003	Belongs to the UPF0758 family
VAA_01243	COG3706	GGDEF domain
VAA_01244	COG1349	DNA-binding transcription factor activity
VAA_01250	COG1175	transmembrane transport
VAA_01252	COG3842	ATPase activity
VAA_01254	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VAA_01256	COG0784	Response regulator, receiver
VAA_01256	COG0835	chemotaxis
VAA_01257	COG2315	Protein conserved in bacteria
VAA_01265	COG5001	Diguanylate cyclase
VAA_01267	COG1741	Belongs to the pirin family
VAA_01269	COG3123	guanosine phosphorylase activity
VAA_01271	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VAA_01272	COG1126	abc transporter atp-binding protein
VAA_01273	COG0765	amino acid transport
VAA_01274	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAA_01275	COG0765	amino acid transport
VAA_01277	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VAA_01281	COG0179	Fumarylacetoacetate (FAA) hydrolase
VAA_012815	COG0513	Belongs to the DEAD box helicase family
VAA_012817	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VAA_01283	COG0697	spore germination
VAA_01287	COG2814	Major facilitator Superfamily
VAA_01288	COG0583	DNA-binding transcription factor activity
VAA_01290	COG5001	Diguanylate cyclase
VAA_01291	COG0739	heme binding
VAA_01293	COG0659	secondary active sulfate transmembrane transporter activity
VAA_01297	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VAA_01298	COG0581	inorganic phosphate transmembrane transporter activity
VAA_01299	COG0573	inorganic phosphate transmembrane transporter activity
VAA_01300	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VAA_01302	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAA_01303	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VAA_01309	COG3047	cAMP biosynthetic process
VAA_01311	COG3397	chitin binding
VAA_01312	COG2271	Major facilitator Superfamily
VAA_01313	COG0584	glycerophosphoryl diester phosphodiesterase
VAA_01315	COG3527	Alpha-acetolactate decarboxylase
VAA_01320	COG0583	DNA-binding transcription factor activity
VAA_01321	COG1620	l-lactate permease
VAA_01322	COG1304	FMN binding
VAA_01325	COG1881	PFAM PEBP family protein
VAA_01327	COG3122	Protein conserved in bacteria
VAA_01330	COG3568	Endonuclease Exonuclease Phosphatase
VAA_01333	COG0840	transmembrane signaling receptor activity
VAA_01335	COG0840	transmembrane signaling receptor activity
VAA_01336	COG1609	Transcriptional regulator
VAA_01337	COG1472	Belongs to the glycosyl hydrolase 3 family
VAA_01338	COG3842	ATPase activity
VAA_01339	COG0395	ABC-type sugar transport system, permease component
VAA_01342	COG1609	Transcriptional regulator
VAA_01343	COG4580	involved in the transport of maltose and maltodextrins
VAA_01348	COG2211	Major facilitator Superfamily
VAA_01350	COG1067	ATP-dependent peptidase activity
VAA_01352	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VAA_01353	COG0363	glucosamine-6-phosphate deaminase activity
VAA_01356	COG0583	DNA-binding transcription factor activity
VAA_01361	COG0251	oxidation-reduction process
VAA_01363	COG1294	oxidase, subunit
VAA_01367	COG3220	belongs to the UPF0276 family
VAA_01373	COG0840	transmembrane signaling receptor activity
VAA_01374	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VAA_01375	COG2200	EAL domain
VAA_01376	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VAA_01377	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VAA_01377	COG1263	PTS System
VAA_01379	COG1621	beta-fructofuranosidase activity
VAA_01383	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VAA_01384	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VAA_01387	COG0848	biopolymer transport protein
VAA_01388	COG0811	peptide transport
VAA_01389	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VAA_01390	COG3721	Heme iron utilization protein
VAA_01391	COG0748	coenzyme F420 binding
VAA_01392	COG4771	TonB-dependent receptor
VAA_01392	COG1629	transport
VAA_01393	COG1940	carbohydrate kinase activity
VAA_01399	COG2989	Protein conserved in bacteria
VAA_01400	COG3108	Peptidase M15
VAA_01401	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VAA_01404	COG1846	Transcriptional regulator
VAA_01405	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VAA_01406	COG0840	transmembrane signaling receptor activity
VAA_01408	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
VAA_01409	COG1448	Aminotransferase
VAA_01410	COG3437	response regulator, receiver
VAA_01410	COG2770	Histidine kinase
VAA_01411	COG0840	transmembrane signaling receptor activity
VAA_01412	COG0745	RESPONSE REGULATOR receiver
VAA_01414	COG0643	Histidine kinase
VAA_01414	COG2198	Histidine kinase
VAA_01416	COG0835	chemotaxis
VAA_01417	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VAA_01418	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
VAA_01419	COG2201	protein-glutamate methylesterase activity
VAA_01421	COG0017	Asparaginyl-tRNA synthetase
VAA_01422	COG0840	transmembrane signaling receptor activity
VAA_01423	COG0720	synthase
VAA_01424	COG2356	endonuclease I
VAA_01426	COG1760	l-serine dehydratase
VAA_01427	COG0814	amino acid
VAA_01428	COG0494	nUDIX hydrolase
VAA_01429	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VAA_01432	COG3106	COG3106 Predicted ATPase
VAA_01433	COG3768	UPF0283 membrane protein
VAA_01434	COG3283	Transcriptional regulator of aromatic amino acids metabolism
VAA_01435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VAA_01437	COG3706	GGDEF domain
VAA_01439	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VAA_01441	COG0471	metal ion transport
VAA_01442	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAA_01442	COG4191	Histidine kinase
VAA_01445	COG1278	Cold shock
VAA_01446	COG3005	denitrification pathway
VAA_01447	COG0243	molybdopterin cofactor binding
VAA_01450	COG0513	Belongs to the DEAD box helicase family
VAA_01451	COG2723	6-phospho-beta-galactosidase activity
VAA_01452	COG1609	Transcriptional regulator
VAA_01458	COG0443	Heat shock 70 kDa protein
VAA_01461	COG5002	protein histidine kinase activity
VAA_01461	COG5001	Diguanylate cyclase
VAA_01465	COG1643	Atp-dependent helicase
VAA_01467	COG0583	DNA-binding transcription factor activity
VAA_01468	COG0477	Major facilitator Superfamily
VAA_01471	COG0673	inositol 2-dehydrogenase activity
VAA_01472	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VAA_01473	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VAA_01473	COG0517	IMP dehydrogenase activity
VAA_01474	COG2176	DNA-directed DNA polymerase activity
VAA_01477	COG3718	enzyme involved in inositol metabolism
VAA_01478	COG3962	Belongs to the TPP enzyme family
VAA_01479	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VAA_01487	COG0673	inositol 2-dehydrogenase activity
VAA_01494	COG0784	Response regulator, receiver
VAA_01494	COG3437	response regulator, receiver
VAA_01497	COG0484	heat shock protein binding
VAA_01499	COG5001	Diguanylate cyclase
VAA_01499	COG1716	ATPase activity
VAA_01501	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VAA_01503	COG4181	ATPase activity
VAA_01504	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
VAA_01506	COG1984	allophanate hydrolase subunit 2
VAA_01508	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VAA_01509	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VAA_01511	COG0814	amino acid
VAA_01512	COG0513	Belongs to the DEAD box helicase family
VAA_01514	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
VAA_01517	COG2425	protein containing a von Willebrand factor type A (vWA) domain
VAA_01518	COG0517	IMP dehydrogenase activity
VAA_01518	COG4175	Glycine betaine
VAA_01519	COG4176	ABC-type proline glycine betaine transport system permease component
VAA_01525	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VAA_01526	COG2146	nitrite reductase [NAD(P)H] activity
VAA_01529	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VAA_01533	COG3118	belongs to the thioredoxin family
VAA_01534	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VAA_01535	COG0247	lactate metabolic process
VAA_01536	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
VAA_01537	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VAA_01538	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VAA_01539	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VAA_01544	COG2827	Endonuclease containing a URI domain
VAA_01548	COG5002	protein histidine kinase activity
VAA_01548	COG0784	Response regulator, receiver
VAA_01555	COG1289	transmembrane transporter activity
VAA_01556	COG0210	DNA helicase
VAA_01557	COG1803	Methylglyoxal synthase
VAA_01558	COG1879	ABC-type sugar transport system periplasmic component
VAA_01560	COG2205	protein histidine kinase activity
VAA_01560	COG2198	Histidine kinase
VAA_01560	COG0784	Response regulator, receiver
VAA_01561	COG0469	pyruvate kinase activity
VAA_01562	COG2271	Major facilitator Superfamily
VAA_01564	COG1840	ABC-type Fe3 transport system, periplasmic component
VAA_01567	COG1979	alcohol dehydrogenase
VAA_01568	COG2207	Transcriptional regulator
VAA_01570	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VAA_01571	COG3447	MASE1 domain protein
VAA_01571	COG5001	Diguanylate cyclase
VAA_01571	COG5002	protein histidine kinase activity
VAA_01573	COG3111	PFAM Bacterial OB fold (BOF) protein
VAA_01574	COG1492	cobalamin metabolic process
VAA_01575	COG0725	ABC transporter, periplasmic molybdate-binding protein
VAA_01576	COG4149	molybdate abc transporter
VAA_01577	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
VAA_01579	COG4251	negative regulation of phosphorylation
VAA_01579	COG5001	Diguanylate cyclase
VAA_01579	COG3706	GGDEF domain
VAA_01579	COG2203	Gaf domain
VAA_01582	COG3437	response regulator, receiver
VAA_01584	COG3852	Histidine kinase
VAA_01585	COG4191	Histidine kinase
VAA_01586	COG3300	MHYT domain
VAA_01586	COG5001	Diguanylate cyclase
VAA_01591	COG0640	Transcriptional regulator
VAA_01596	COG3706	GGDEF domain
VAA_01597	COG1328	CTP reductase activity
VAA_01598	COG0602	queuosine metabolic process
VAA_01601	COG4067	protein conserved in archaea
VAA_01601	COG0189	ligase activity
VAA_01603	COG4166	transmembrane transport
VAA_01604	COG4174	ABC transporter (Permease)
VAA_01605	COG4239	(ABC) transporter, permease
VAA_01606	COG4172	Belongs to the ABC transporter superfamily
VAA_01607	COG4251	negative regulation of phosphorylation
VAA_01607	COG2203	Gaf domain
VAA_01607	COG3706	GGDEF domain
VAA_01607	COG5001	Diguanylate cyclase
VAA_01610	COG3038	cytochrome b561
VAA_01611	COG2353	YceI-like domain
VAA_01612	COG0840	transmembrane signaling receptor activity
VAA_01613	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VAA_01614	COG0545	Peptidyl-prolyl cis-trans isomerase
VAA_01618	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VAA_01624	COG2897	thiosulfate sulfurtransferase activity
VAA_01625	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VAA_01626	COG0303	'Molybdopterin
VAA_01627	COG0302	gtp cyclohydrolase
VAA_01628	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAA_01628	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAA_01629	COG2759	Belongs to the formate--tetrahydrofolate ligase family
VAA_01631	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VAA_01632	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VAA_01633	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VAA_01634	COG1011	Hydrolase
VAA_01635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VAA_01636	COG2188	Transcriptional regulator
VAA_01640	COG2116	formate transmembrane transporter activity
VAA_01641	COG0583	DNA-binding transcription factor activity
VAA_01643	COG3593	DNA synthesis involved in DNA repair
VAA_01644	COG0737	Belongs to the 5'-nucleotidase family
VAA_01646	COG0861	Integral membrane protein TerC family
VAA_01648	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VAA_01649	COG3091	SprT-like family
VAA_01650	COG2356	endonuclease I
VAA_01651	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VAA_01653	COG1678	Uncharacterized ACR, COG1678
VAA_01654	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VAA_01657	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VAA_01658	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VAA_01659	COG0762	integral membrane protein
VAA_01660	COG1872	DUF167
VAA_01663	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VAA_01664	COG2066	Belongs to the glutaminase family
VAA_01665	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VAA_01668	COG0741	lytic transglycosylase activity
VAA_01669	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VAA_01670	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VAA_01672	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VAA_01673	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VAA_01675	COG2967	ApaG domain
VAA_01678	COG3610	response to peptide
VAA_01679	COG2966	Psort location CytoplasmicMembrane, score
VAA_01680	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VAA_01681	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VAA_01683	COG0142	geranyltranstransferase activity
VAA_01684	COG0531	amino acid
VAA_01690	COG0589	response to stress
VAA_01696	COG3550	peptidyl-serine autophosphorylation
VAA_01699	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VAA_01701	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VAA_01711	COG2235	arginine
VAA_01712	COG0312	modulator of DNA gyrase
VAA_01713	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VAA_01714	COG3164	Protein of unknown function
VAA_01715	COG1530	ribonuclease E activity
VAA_01717	COG0424	maF-like protein
VAA_01718	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VAA_01719	COG1792	Involved in formation and maintenance of cell shape
VAA_01720	COG1077	Cell shape determining protein MreB Mrl
VAA_01729	COG1459	type II secretion system
VAA_01730	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VAA_01732	COG3409	Peptidoglycan-binding domain 1 protein
VAA_01732	COG3267	Type II secretory pathway component ExeA
VAA_01738	COG2200	EAL domain
VAA_01738	COG2199	diguanylate cyclase activity
VAA_01739	COG0629	single-stranded DNA binding
VAA_01742	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VAA_01744	COG2239	Acts as a magnesium transporter
VAA_01746	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VAA_01747	COG0527	aspartate kinase activity
VAA_01748	COG0646	methionine synthase
VAA_01748	COG1410	methionine synthase
VAA_01756	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VAA_01758	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VAA_01759	COG0408	coproporphyrinogen oxidase activity
VAA_01760	COG0009	L-threonylcarbamoyladenylate synthase
VAA_01761	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VAA_01762	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VAA_01764	COG0551	DNA topoisomerase type I activity
VAA_01765	COG2922	Belongs to the Smg family
VAA_01766	COG0758	DNA mediated transformation
VAA_01767	COG0758	DNA mediated transformation
VAA_01768	COG1652	LysM domain
VAA_01769	COG0242	peptide deformylase activity
VAA_01770	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VAA_01771	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VAA_01771	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VAA_01772	COG0569	domain protein
VAA_01773	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VAA_01775	COG1272	protein, Hemolysin III
VAA_01778	COG3084	Protein conserved in bacteria
VAA_01780	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VAA_01781	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VAA_01785	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VAA_01786	COG1280	lysine exporter protein (LysE YggA)
VAA_01787	COG1115	amino acid carrier protein
VAA_01790	COG2195	Cleaves the N-terminal amino acid of tripeptides
VAA_01792	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VAA_01794	COG0625	glutathione transferase activity
VAA_01800	COG0811	peptide transport
VAA_01801	COG0811	peptide transport
VAA_01802	COG0848	biopolymer transport protein
VAA_01805	COG4667	esterase of the alpha-beta hydrolase superfamily
VAA_01811	COG0791	NLP P60 protein
VAA_01812	COG0840	transmembrane signaling receptor activity
VAA_01817	COG1763	Mo-molybdopterin cofactor biosynthetic process
VAA_01818	COG0746	molybdenum cofactor guanylyltransferase activity
VAA_01820	COG3842	ATPase activity
VAA_01823	COG1840	ABC-type Fe3 transport system, periplasmic component
VAA_01824	COG2271	Major facilitator Superfamily
VAA_01826	COG2197	response regulator
VAA_01828	COG0488	(ABC) transporter
VAA_01829	COG0004	ammonium transporteR
VAA_01830	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VAA_01831	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VAA_01832	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VAA_01833	COG1177	transmembrane transport
VAA_01834	COG1176	ABC-type spermidine putrescine transport system, permease component I
VAA_01835	COG3842	ATPase activity
VAA_01840	COG0589	response to stress
VAA_01841	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VAA_01845	COG2217	Heavy metal translocating P-type atpase
VAA_01847	COG2010	Cytochrome c
VAA_01850	COG3278	Belongs to the heme-copper respiratory oxidase family
VAA_01855	COG3120	sequence-specific DNA binding
VAA_01857	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VAA_01862	COG0116	Belongs to the methyltransferase superfamily
VAA_01862	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VAA_01864	COG0167	dihydroorotate dehydrogenase activity
VAA_01865	COG2902	Dehydrogenase
VAA_01868	COG0308	aminopeptidase N
VAA_01873	COG1956	GAF domain-containing protein
VAA_01874	COG1132	(ABC) transporter
VAA_01875	COG2995	paraquat-inducible protein a
VAA_01876	COG3008	intermembrane lipid transfer
VAA_01877	COG3008	intermembrane lipid transfer
VAA_01879	COG2996	Protein conserved in bacteria
VAA_01883	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VAA_01887	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VAA_01887	COG1648	precorrin-2 dehydrogenase activity
VAA_01888	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAA_01889	COG4597	amino acid ABC transporter
VAA_01890	COG0765	amino acid transport
VAA_01891	COG1126	abc transporter atp-binding protein
VAA_01892	COG0670	Belongs to the BI1 family
VAA_01893	COG2920	part of a sulfur-relay system
VAA_01894	COG1254	Belongs to the acylphosphatase family
VAA_01895	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VAA_01898	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VAA_01899	COG1444	tRNA N-acetyltransferase activity
VAA_01901	COG0745	RESPONSE REGULATOR receiver
VAA_01902	COG0643	Histidine kinase
VAA_01902	COG2198	Histidine kinase
VAA_01903	COG0835	chemotaxis
VAA_01904	COG0835	chemotaxis
VAA_01905	COG0840	transmembrane signaling receptor activity
VAA_01906	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VAA_01907	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
VAA_01912	COG3706	GGDEF domain
VAA_01912	COG0745	RESPONSE REGULATOR receiver
VAA_01918	COG0259	pyridoxamine-phosphate oxidase activity
VAA_01920	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VAA_01927	COG0840	transmembrane signaling receptor activity
VAA_01933	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VAA_01938	COG2909	trisaccharide binding
VAA_01939	COG0058	SHG alpha-glucan phosphorylase activity
VAA_01940	COG1640	4-alpha-glucanotransferase
VAA_01941	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VAA_01944	COG3501	Rhs element vgr protein
VAA_01948	COG3071	HemY protein
VAA_01949	COG2959	enzyme of heme biosynthesis
VAA_01950	COG1587	Uroporphyrinogen-III synthase
VAA_01952	COG3072	Adenylate cyclase
VAA_01955	COG0019	diaminopimelate decarboxylase activity
VAA_01958	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VAA_01959	COG1011	Hydrolase
VAA_01962	COG0561	phosphatase activity
VAA_01963	COG2267	carboxylic ester hydrolase activity
VAA_01964	COG1280	lysine exporter protein (LysE YggA)
VAA_01965	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VAA_01966	COG0783	Belongs to the Dps family
VAA_01973	COG2095	MarC family integral membrane protein
VAA_01974	COG0840	transmembrane signaling receptor activity
VAA_01976	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VAA_01977	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VAA_01979	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VAA_01988	COG0019	diaminopimelate decarboxylase activity
VAA_01991	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VAA_01994	COG4181	ATPase activity
VAA_01995	COG0534	Mate efflux family protein
VAA_01996	COG0702	epimerase
VAA_01998	COG2814	Major facilitator Superfamily
VAA_01999	COG1187	pseudouridine synthase activity
VAA_02000	COG1061	Type III restriction enzyme res subunit
VAA_02003	COG2205	protein histidine kinase activity
VAA_02007	COG0513	Belongs to the DEAD box helicase family
VAA_02011	COG0840	transmembrane signaling receptor activity
VAA_02016	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
VAA_02020	COG5016	pyruvate
VAA_02020	COG0511	ligase activity, forming carbon-carbon bonds
VAA_02021	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VAA_02023	COG4565	transcriptional regulatory protein
VAA_02025	COG3052	prosthetic group binding
VAA_02026	COG2301	Belongs to the HpcH HpaI aldolase family
VAA_02027	COG3051	citrate lyase alpha subunit
VAA_02028	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
VAA_02029	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
VAA_02034	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAA_02034	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VAA_02034	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VAA_02035	COG2207	Transcriptional regulator
VAA_02037	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VAA_02039	COG1342	Belongs to the UPF0251 family
VAA_02043	COG1129	ABC transporter
VAA_02045	COG0583	DNA-binding transcription factor activity
VAA_02046	COG1902	pentaerythritol trinitrate reductase activity
VAA_02047	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VAA_02048	COG5002	protein histidine kinase activity
VAA_02049	COG0745	RESPONSE REGULATOR receiver
VAA_02057	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VAA_02058	COG0372	Belongs to the citrate synthase family
VAA_02060	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
VAA_02061	COG2828	Protein conserved in bacteria
VAA_02065	COG0561	phosphatase activity
VAA_02066	COG0602	queuosine metabolic process
VAA_02072	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VAA_02076	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VAA_02078	COG2382	esterase
VAA_02079	COG1629	transport
VAA_02079	COG4774	siderophore transport
VAA_02081	COG4657	Part of a membrane complex involved in electron transport
VAA_02082	COG2878	Part of a membrane complex involved in electron transport
VAA_02083	COG4656	Part of a membrane complex involved in electron transport
VAA_02084	COG4658	electron transport chain
VAA_02087	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VAA_02088	COG0346	lactoylglutathione lyase activity
VAA_02090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VAA_02091	COG2056	Na+-H+ antiporter family
VAA_02092	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VAA_02093	COG1286	toxin biosynthetic process
VAA_02094	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VAA_02095	COG0285	dihydrofolate synthase activity
VAA_02099	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VAA_02100	COG1263	PTS System
VAA_02100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VAA_02100	COG2190	(PTS) system
VAA_02102	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VAA_02103	COG1846	Transcriptional regulator
VAA_02103	COG1940	carbohydrate kinase activity
VAA_02104	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VAA_02104	COG4651	solute:proton antiporter activity
VAA_02105	COG0367	asparagine synthase
VAA_02107	COG3104	oligopeptide transport
VAA_02108	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VAA_02110	COG0326	Molecular chaperone. Has ATPase activity
VAA_02111	COG3710	Transcriptional regulator
VAA_02114	COG0622	Phosphoesterase
VAA_02115	COG1090	epimerase
VAA_02116	COG3118	belongs to the thioredoxin family
VAA_02118	COG0330	HflC and HflK could
VAA_02120	COG0789	Transcriptional regulator
VAA_02125	COG0564	pseudouridine synthase activity
VAA_02126	COG0733	neurotransmitter:sodium symporter activity
VAA_02128	COG0626	cystathionine gamma-synthase activity
VAA_02129	COG0519	Catalyzes the synthesis of GMP from XMP
VAA_02132	COG1842	Phage shock protein A
VAA_02133	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VAA_02135	COG4168	peptide transport system, permease
VAA_02136	COG4171	peptide transport system, permease
VAA_02139	COG4172	Belongs to the ABC transporter superfamily
VAA_02142	COG1227	inorganic diphosphatase activity
VAA_02145	COG0243	molybdopterin cofactor binding
VAA_02146	COG3005	denitrification pathway
VAA_02147	COG4459	periplasmic nitrate reductase
VAA_02148	COG2116	formate transmembrane transporter activity
VAA_02153	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VAA_02154	COG1435	thymidine kinase activity
VAA_02155	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VAA_02156	COG1801	Protein of unknown function DUF72
VAA_02159	COG4106	trans-aconitate 2-methyltransferase activity
VAA_02161	COG0189	ligase activity
VAA_02161	COG4067	protein conserved in archaea
VAA_02164	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VAA_02165	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VAA_02167	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VAA_02168	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VAA_02169	COG0745	RESPONSE REGULATOR receiver
VAA_02171	COG1609	Transcriptional regulator
VAA_02172	COG3070	regulator of competence-specific genes
VAA_02176	COG0297	glycogen (starch) synthase activity
VAA_02177	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VAA_02178	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VAA_02182	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VAA_02183	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VAA_02184	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VAA_02185	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VAA_02186	COG0542	response to heat
VAA_02187	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VAA_02189	COG1278	Cold shock
VAA_02191	COG1187	pseudouridine synthase activity
VAA_02192	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VAA_02192	COG0140	phosphoribosyl-ATP diphosphatase activity
VAA_02193	COG0107	imidazoleglycerol-phosphate synthase activity
VAA_02194	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VAA_02195	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VAA_02196	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VAA_02196	COG0131	Imidazoleglycerol-phosphate dehydratase
VAA_02198	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VAA_02199	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VAA_02202	COG1757	Na H antiporter
VAA_02204	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VAA_02206	COG0482	sulfurtransferase activity
VAA_02207	COG2915	High frequency lysogenization protein hflD homolog
VAA_02208	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VAA_02209	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VAA_02211	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAA_02211	COG4191	Histidine kinase
VAA_02214	COG3070	regulator of competence-specific genes
VAA_02216	COG2431	L-lysine efflux transmembrane transporter activity
VAA_02218	COG0076	glutamate decarboxylase activity
VAA_02219	COG1737	Transcriptional regulator
VAA_02221	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VAA_02226	COG0281	malic enzyme
VAA_02228	COG2949	membrane
VAA_02231	COG0745	RESPONSE REGULATOR receiver
VAA_02231	COG3706	GGDEF domain
VAA_02232	COG0492	ferredoxin-NADP+ reductase activity
VAA_02233	COG4988	ABC transporter
VAA_02234	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VAA_02239	COG1595	DNA-templated transcription, initiation
VAA_02242	COG1187	pseudouridine synthase activity
VAA_02243	COG0009	L-threonylcarbamoyladenylate synthase
VAA_02244	COG0613	PHP domain protein
VAA_02247	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VAA_02248	COG0512	Glutamine amidotransferase of anthranilate synthase
VAA_02249	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VAA_02250	COG0134	indole-3-glycerol-phosphate synthase activity
VAA_02250	COG0135	phosphoribosylanthranilate isomerase activity
VAA_02251	COG0133	tryptophan synthase activity
VAA_02258	COG1607	acyl-coa hydrolase
VAA_02259	COG2350	Protein conserved in bacteria
VAA_02261	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VAA_02262	COG0583	DNA-binding transcription factor activity
VAA_02265	COG2199	diguanylate cyclase activity
VAA_02265	COG2200	EAL domain
VAA_02265	COG2203	Gaf domain
VAA_02267	COG1032	radical SAM domain protein
VAA_02269	COG2268	Band 7 protein
VAA_02271	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VAA_02274	COG0300	oxidoreductase activity
VAA_02276	COG0501	Belongs to the peptidase M48B family
VAA_02278	COG1674	ftsk spoiiie
VAA_02280	COG1522	sequence-specific DNA binding
VAA_02281	COG0686	Belongs to the AlaDH PNT family
VAA_02286	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VAA_02287	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VAA_02289	COG0539	negative regulation of cytoplasmic translation
VAA_02290	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VAA_02292	COG1555	photosystem II stabilization
VAA_02293	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VAA_02294	COG0776	regulation of translation
VAA_02295	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VAA_02298	COG0544	peptidyl-prolyl cis-trans isomerase activity
VAA_02302	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VAA_02303	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VAA_02305	COG1653	transport
VAA_02306	COG2205	protein histidine kinase activity
VAA_02307	COG0745	RESPONSE REGULATOR receiver
VAA_02308	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VAA_02309	COG1760	l-serine dehydratase
VAA_02311	COG0513	Belongs to the DEAD box helicase family
VAA_02313	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VAA_02316	COG4628	conserved protein (DUF2132)
VAA_02322	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VAA_02323	COG0583	DNA-binding transcription factor activity
VAA_02324	COG2951	lytic endotransglycosylase activity
VAA_02325	COG3100	YcgL domain-containing protein
VAA_02327	COG2894	cell division
VAA_02329	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VAA_02330	COG0318	PFAM AMP-dependent synthetase and ligase
VAA_02331	COG0596	Alpha beta hydrolase
VAA_02334	COG1214	PFAM Peptidase M22, glycoprotease
VAA_02335	COG1199	ATP-dependent helicase activity
VAA_02337	COG0788	formyltetrahydrofolate deformylase activity
VAA_02338	COG0446	pyridine nucleotide-disulphide oxidoreductase
VAA_02338	COG1902	pentaerythritol trinitrate reductase activity
VAA_02339	COG0616	signal peptide processing
VAA_02340	COG0252	asparaginase activity
VAA_02341	COG3139	Protein of unknown function (DUF1315)
VAA_02343	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAA_02346	COG2226	methyltransferase
VAA_02352	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VAA_02354	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VAA_02355	COG2832	Protein of unknown function (DUF454)
VAA_02357	COG0745	RESPONSE REGULATOR receiver
VAA_02358	COG0583	DNA-binding transcription factor activity
VAA_02359	COG0778	Nitroreductase
VAA_02362	COG0183	Belongs to the thiolase family
VAA_02363	COG1595	DNA-templated transcription, initiation
VAA_02365	COG2067	long-chain fatty acid transport protein
VAA_02366	COG2067	long-chain fatty acid transport protein
VAA_02367	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VAA_02369	COG0572	uridine kinase
VAA_02370	COG0489	protein tyrosine kinase activity
VAA_02371	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VAA_02371	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VAA_02373	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VAA_02376	COG4109	DRTGG domain
VAA_02377	COG2199	diguanylate cyclase activity
VAA_02378	COG0314	molybdopterin synthase activity
VAA_02379	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VAA_02381	COG0521	Mo-molybdopterin cofactor biosynthetic process
VAA_02382	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VAA_02383	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VAA_02384	COG2198	Histidine kinase
VAA_02385	COG2204	response regulator
VAA_02386	COG0556	nucleotide-excision repair
VAA_02390	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VAA_02392	COG1028	Short-chain dehydrogenase reductase Sdr
VAA_02393	COG1169	isochorismate synthase
VAA_02394	COG1021	2,3-dihydroxybenzoate-AMP ligase
VAA_02395	COG1535	isochorismatase
VAA_02395	COG3433	isochorismatase activity
VAA_02401	COG5290	Psort location Cytoplasmic, score
VAA_02408	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VAA_02410	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VAA_02411	COG0339	signal peptide processing
VAA_02412	COG0210	DNA helicase
VAA_02413	COG1280	lysine exporter protein (LysE YggA)
VAA_02415	COG2962	Rard protein
VAA_02416	COG0514	ATP-dependent DNA helicase (RecQ)
VAA_02420	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VAA_02421	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VAA_02421	COG1263	PTS System
VAA_02422	COG1132	(ABC) transporter
VAA_02423	COG4774	siderophore transport
VAA_02424	COG1120	ATPase activity
VAA_02430	COG0612	Peptidase, M16
VAA_02438	COG1061	Type III restriction enzyme res subunit
VAA_02445	COG1396	sequence-specific DNA binding
VAA_02448	COG1561	YicC-like family, N-terminal region
VAA_02449	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VAA_02451	COG1560	Kdo2-lipid A biosynthetic process
VAA_02453	COG1309	transcriptional regulator
VAA_02454	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VAA_02457	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VAA_02459	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VAA_02460	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VAA_02462	COG0463	Glycosyl transferase, family 2
VAA_02463	COG0859	PFAM glycosyl transferase family 9
VAA_02464	COG3642	lipopolysaccharide core region biosynthetic process
VAA_02467	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VAA_02469	COG1519	Transferase
VAA_02472	COG0859	PFAM glycosyl transferase family 9
VAA_02473	COG3307	-O-antigen
VAA_02475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VAA_02480	COG1682	transport, permease protein
VAA_02483	COG5433	transposase activity
VAA_02488	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
VAA_02491	COG0028	Belongs to the TPP enzyme family
VAA_02496	COG0463	Glycosyl transferase, family 2
VAA_02506	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VAA_02508	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAA_02512	COG1596	polysaccharide export
VAA_02513	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VAA_02520	COG0438	transferase activity, transferring glycosyl groups
VAA_02523	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VAA_02524	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VAA_02525	COG0840	transmembrane signaling receptor activity
VAA_02526	COG0668	transmembrane transport
VAA_02527	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAA_02528	COG3068	Protein conserved in bacteria
VAA_02529	COG2852	Protein conserved in bacteria
VAA_02530	COG1253	flavin adenine dinucleotide binding
VAA_02532	COG0776	regulation of translation
VAA_02534	COG0151	Belongs to the GarS family
VAA_02537	COG0789	Transcriptional regulator
VAA_02538	COG0840	transmembrane signaling receptor activity
VAA_02540	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VAA_02541	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VAA_02543	COG2264	protein methyltransferase activity
VAA_02544	COG0439	Biotin carboxylase
VAA_02545	COG0511	ligase activity, forming carbon-carbon bonds
VAA_02546	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VAA_02547	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VAA_02550	COG2814	Major facilitator Superfamily
VAA_02551	COG2198	Histidine kinase
VAA_02551	COG0784	Response regulator, receiver
VAA_02551	COG2205	protein histidine kinase activity
VAA_02552	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VAA_02554	COG3263	regulation of cellular component size
VAA_02556	COG4232	protein-disulfide reductase activity
VAA_02557	COG1438	arginine binding
VAA_02559	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VAA_02560	COG0540	Belongs to the ATCase OTCase family
VAA_02561	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VAA_02562	COG0549	Belongs to the carbamate kinase family
VAA_02565	COG1288	antiporter activity
VAA_02566	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VAA_02568	COG1027	Aspartate ammonia-lyase
VAA_02569	COG3030	protein affecting phage T7 exclusion by the F plasmid
VAA_02570	COG1278	Cold shock
VAA_02571	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VAA_02572	COG2205	protein histidine kinase activity
VAA_02573	COG0745	RESPONSE REGULATOR receiver
VAA_02575	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VAA_02577	COG0205	6-phosphofructokinase activity
VAA_02578	COG1494	fructose-1,6-bisphosphatase
VAA_02580	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VAA_02581	COG0527	aspartate kinase activity
VAA_02581	COG0460	homoserine dehydrogenase
VAA_02582	COG0626	cystathionine gamma-synthase activity
VAA_02584	COG0281	malic enzyme
VAA_02586	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VAA_02587	COG1609	Transcriptional regulator
VAA_02591	COG1575	Belongs to the MenA family. Type 1 subfamily
VAA_02592	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VAA_02593	COG0534	Mate efflux family protein
VAA_02595	COG0149	triose-phosphate isomerase activity
VAA_02601	COG0459	protein refolding
VAA_02604	COG1509	lysine 2,3-aminomutase activity
VAA_02605	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VAA_02607	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VAA_02608	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VAA_02609	COG1053	succinate dehydrogenase
VAA_02610	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VAA_02611	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VAA_02613	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VAA_02614	COG1045	serine acetyltransferase
VAA_02618	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VAA_02619	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VAA_02622	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VAA_02622	COG0165	Argininosuccinate lyase
VAA_02624	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VAA_02625	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VAA_02625	COG0678	peroxiredoxin activity
VAA_02627	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VAA_02633	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VAA_02636	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VAA_02637	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VAA_02638	COG0546	phosphoglycolate phosphatase activity
VAA_02639	COG0180	Tryptophanyl-tRNA synthetase
VAA_02642	COG0583	DNA-binding transcription factor activity
VAA_02644	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAA_02647	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VAA_02651	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VAA_02652	COG3954	Phosphoribulokinase
VAA_02654	COG0429	hydrolase of the alpha beta-hydrolase fold
VAA_02656	COG0488	(ABC) transporter
VAA_02657	COG2249	NAD(P)H dehydrogenase (quinone) activity
VAA_02659	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
VAA_02660	COG1047	Peptidyl-prolyl cis-trans
VAA_02663	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VAA_02665	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VAA_02666	COG0557	exoribonuclease II activity
VAA_02667	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VAA_02669	COG0051	transcription antitermination factor activity, RNA binding
VAA_02674	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VAA_02679	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VAA_02680	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VAA_02684	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VAA_02685	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VAA_02690	COG0201	protein transport
VAA_02692	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VAA_02693	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VAA_02694	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VAA_02696	COG0203	ribosomal protein L17
VAA_02697	COG0545	Peptidyl-prolyl cis-trans isomerase
VAA_02698	COG3061	Opacity-associated protein A
VAA_02698	COG3266	domain, Protein
VAA_02699	COG2153	protein acetylation
VAA_02700	COG0513	Belongs to the DEAD box helicase family
VAA_02706	COG1181	Belongs to the D-alanine--D-alanine ligase family
VAA_02706	COG2918	glutathione biosynthetic process
VAA_02706	COG0189	ligase activity
VAA_02709	COG0737	Belongs to the 5'-nucleotidase family
VAA_02710	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VAA_02710	COG1648	precorrin-2 dehydrogenase activity
VAA_02711	COG0175	sulfate reduction
VAA_02712	COG2895	sulfate adenylyltransferase (ATP) activity
VAA_02713	COG0529	Catalyzes the synthesis of activated sulfate
VAA_02720	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VAA_02721	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAA_02722	COG0729	surface antigen
VAA_02723	COG2911	Protein conserved in bacteria
VAA_02724	COG2105	PFAM AIG2 family protein
VAA_02725	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VAA_02726	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VAA_02727	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VAA_02728	COG0163	prenyltransferase activity
VAA_02729	COG4143	(ABC) transporter
VAA_02730	COG1178	ABC-type Fe3 transport system permease component
VAA_02731	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VAA_02732	COG3028	Belongs to the UPF0307 family
VAA_02733	COG0312	modulator of DNA gyrase
VAA_02734	COG2239	Acts as a magnesium transporter
VAA_02735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAA_02737	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAA_02738	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VAA_02740	COG1137	ATPase activity
VAA_02741	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VAA_02743	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VAA_02744	COG0517	IMP dehydrogenase activity
VAA_02744	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VAA_02748	COG1127	ABC transporter
VAA_02749	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VAA_02750	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VAA_02751	COG2854	intermembrane phospholipid transfer
VAA_02753	COG5007	Belongs to the BolA IbaG family
VAA_02754	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VAA_02755	COG0204	Acyl-transferase
VAA_02758	COG0251	oxidation-reduction process
VAA_02759	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VAA_02764	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VAA_02765	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VAA_02768	COG0564	pseudouridine synthase activity
VAA_02769	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VAA_02770	COG0525	valine-tRNA ligase activity
VAA_02771	COG2927	DNA polymerase III (CHI subunit)
VAA_02772	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VAA_02773	COG0795	lipopolysaccharide-transporting ATPase activity
VAA_02774	COG0795	lipopolysaccharide-transporting ATPase activity
VAA_02787	COG0363	glucosamine-6-phosphate deaminase activity
VAA_02788	COG0739	heme binding
VAA_02789	COG2213	PTS system mannitol-specific
VAA_02789	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAA_02790	COG0246	Mannitol dehydrogenase
VAA_02791	COG3722	fumarate hydratase activity
VAA_02793	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
VAA_02794	COG1301	dicarboxylic acid transport
VAA_02795	COG2259	Doxx family
VAA_02800	COG1846	Transcriptional regulator
VAA_02802	COG4943	cyclic-guanylate-specific phosphodiesterase activity
VAA_02803	COG3046	protein related to deoxyribodipyrimidine photolyase
VAA_02804	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VAA_02805	COG0842	Transport permease protein
VAA_02806	COG1131	(ABC) transporter
VAA_02809	COG3842	ATPase activity
VAA_02811	COG1176	ABC-type spermidine putrescine transport system, permease component I
VAA_02816	COG0251	oxidation-reduction process
VAA_02819	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VAA_02820	COG1328	CTP reductase activity
VAA_02822	COG2130	NADP-dependent
VAA_02823	COG1309	transcriptional regulator
VAA_02826	COG0745	RESPONSE REGULATOR receiver
VAA_02828	COG0564	pseudouridine synthase activity
VAA_02849	COG3501	Rhs element vgr protein
VAA_02860	COG0471	metal ion transport
VAA_02861	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VAA_02863	COG2188	Transcriptional regulator
VAA_02864	COG1131	(ABC) transporter
VAA_02866	COG0840	transmembrane signaling receptor activity
VAA_02872	COG0671	phosphoesterase, PA-phosphatase related
VAA_02873	COG4399	Belongs to the UPF0754 family
VAA_02874	COG1132	(ABC) transporter
VAA_02878	COG5001	Diguanylate cyclase
VAA_02881	COG3623	hexulose-6-phosphate isomerase
VAA_02882	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
VAA_02883	COG0561	phosphatase activity
VAA_02898	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
VAA_02900	COG1999	signal sequence binding
VAA_02903	COG0786	glutamate:sodium symporter activity
VAA_02908	COG1566	PFAM secretion protein HlyD family protein
VAA_02910	COG3706	GGDEF domain
VAA_02913	COG0813	purine-nucleoside phosphorylase activity
VAA_02914	COG3272	Protein of unknown function (DUF1722)
VAA_02915	COG0789	Transcriptional regulator
VAA_02916	COG0415	Belongs to the DNA photolyase family
VAA_02917	COG1376	ErfK ybiS ycfS ynhG family protein
VAA_02917	COG1388	LysM domain
VAA_02919	COG0513	Belongs to the DEAD box helicase family
VAA_02927	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VAA_02928	COG3457	Alanine racemase
VAA_02931	COG1735	metal-dependent hydrolase with the TIM-barrel fold
VAA_02933	COG2188	Transcriptional regulator
VAA_02934	COG2267	carboxylic ester hydrolase activity
VAA_02937	COG0366	Alpha amylase catalytic
VAA_02939	COG4989	oxidoreductase activity
VAA_02942	COG1136	(ABC) transporter
VAA_02942	COG0577	efflux transmembrane transporter activity
VAA_02943	COG4591	ABC-type transport system involved in lipoprotein release permease component
VAA_02946	COG0745	RESPONSE REGULATOR receiver
VAA_02946	COG2972	Histidine kinase
VAA_02947	COG3279	Response regulator of the LytR AlgR family
VAA_02948	COG2203	Gaf domain
VAA_02948	COG3706	GGDEF domain
VAA_02948	COG5001	Diguanylate cyclase
VAA_02948	COG4251	negative regulation of phosphorylation
VAA_02950	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VAA_02952	COG3437	response regulator, receiver
VAA_02953	COG3850	Histidine kinase
VAA_02953	COG3437	response regulator, receiver
VAA_02953	COG2205	protein histidine kinase activity
VAA_02953	COG4999	Histidine kinase
VAA_02955	COG0531	amino acid
VAA_02961	COG2205	protein histidine kinase activity
VAA_02961	COG0784	Response regulator, receiver
VAA_02961	COG5002	protein histidine kinase activity
VAA_02964	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAA_02965	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VAA_02968	COG0673	inositol 2-dehydrogenase activity
VAA_02969	COG1765	OsmC-like protein
VAA_02970	COG0110	maltose O-acetyltransferase activity
VAA_02973	COG0583	DNA-binding transcription factor activity
VAA_02975	COG0583	DNA-binding transcription factor activity
VAA_02976	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VAA_02977	COG3186	Phenylalanine-4-hydroxylase
VAA_02980	COG0840	transmembrane signaling receptor activity
VAA_02981	COG0534	Mate efflux family protein
VAA_02982	COG2207	Transcriptional regulator
VAA_02984	COG0784	Response regulator, receiver
VAA_02984	COG3437	response regulator, receiver
VAA_02985	COG4191	Histidine kinase
VAA_02985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAA_02987	COG2814	Major facilitator Superfamily
VAA_02988	COG0443	Heat shock 70 kDa protein
VAA_02991	COG3240	lipase activity
VAA_02993	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
VAA_02994	COG5380	lipid catabolic process
VAA_02995	COG4412	M6 family metalloprotease domain protein
VAA_02995	COG3291	Pkd domain containing protein
VAA_03000	COG4607	ABC-type enterochelin transport system periplasmic component
VAA_03001	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VAA_03002	COG4605	iron ion homeostasis
VAA_03003	COG4604	ABC transporter, ATP-binding protein
VAA_03005	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VAA_03011	COG2433	Pfam Transposase IS66
VAA_03021	COG4991	sh3 domain protein
VAA_03021	COG0515	serine threonine protein kinase
VAA_03021	COG3064	Membrane
VAA_03026	COG1716	ATPase activity
VAA_03030	COG1181	Belongs to the D-alanine--D-alanine ligase family
VAA_03042	COG3501	Rhs element vgr protein
VAA_03048	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VAA_03051	COG0745	RESPONSE REGULATOR receiver
VAA_03051	COG3706	GGDEF domain
VAA_03054	COG0835	chemotaxis
VAA_03054	COG0784	Response regulator, receiver
VAA_03056	COG4565	transcriptional regulatory protein
VAA_03057	COG3290	protein histidine kinase activity
VAA_03062	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAA_03067	COG3063	Type IV pilus biogenesis stability protein PilW
VAA_03071	COG1451	nucleotide metabolic process
VAA_03074	COG0583	DNA-binding transcription factor activity
VAA_03079	COG4139	cobalamin transport
VAA_03080	COG2988	succinylglutamate desuccinylase activity
VAA_03083	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VAA_03085	COG3064	Membrane
VAA_03085	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
VAA_03085	COG1073	alpha beta
VAA_03087	COG2994	toxin metabolic process
VAA_03094	COG0702	epimerase
VAA_03096	COG2925	Exonuclease
VAA_03098	COG1346	cytolysis
VAA_03099	COG0295	cytidine deaminase activity
VAA_03100	COG5001	Diguanylate cyclase
VAA_03101	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VAA_03104	COG0500	methyltransferase
VAA_03107	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VAA_03107	COG0072	phenylalanine-tRNA ligase activity
VAA_03109	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VAA_03115	COG0322	excinuclease ABC activity
VAA_03116	COG2197	response regulator
VAA_03117	COG0417	DNA replication proofreading
VAA_03119	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VAA_03120	COG3099	Belongs to the UPF0263 family
VAA_03124	COG1228	amidohydrolase
VAA_03125	COG0010	Belongs to the arginase family
VAA_03127	COG2986	histidine ammonia-lyase
VAA_03130	COG0247	lactate metabolic process
VAA_03130	COG0277	FAD linked oxidase domain protein
VAA_03137	COG1960	acyl-CoA dehydrogenase activity
VAA_03142	COG5001	Diguanylate cyclase
VAA_03142	COG3300	MHYT domain
VAA_03146	COG1401	restriction endodeoxyribonuclease activity
VAA_03151	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VAA_03152	COG2885	chlorophyll binding
VAA_03156	COG0811	peptide transport
VAA_03157	COG0824	Thioesterase
VAA_03158	COG3790	cyd operon protein YbgE
VAA_03159	COG4890	Cyd operon protein YbgT
VAA_03160	COG1294	oxidase, subunit
VAA_03161	COG1271	oxidase subunit
VAA_03163	COG2255	four-way junction helicase activity
VAA_03164	COG0632	four-way junction helicase activity
VAA_03165	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VAA_03166	COG0215	cysteine-tRNA ligase activity
VAA_03167	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VAA_03168	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VAA_03170	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VAA_03173	COG1199	ATP-dependent helicase activity
VAA_03175	COG3923	Primosomal replication protein n
VAA_03177	COG0840	transmembrane signaling receptor activity
VAA_03178	COG0708	Exodeoxyribonuclease III
VAA_03179	COG4160	amino acid transport
VAA_03180	COG4215	(ABC) transporter
VAA_03184	COG1882	Formate acetyltransferase
VAA_03189	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VAA_03192	COG2766	serine protein kinase
VAA_03194	COG2718	Belongs to the UPF0229 family
VAA_03195	COG2719	SpoVR family
VAA_03197	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VAA_03200	COG1132	(ABC) transporter
VAA_03201	COG2333	competence protein COMEC
VAA_03201	COG0658	competence protein
VAA_03203	COG4591	ABC-type transport system involved in lipoprotein release permease component
VAA_03204	COG1136	(ABC) transporter
VAA_03205	COG4591	ABC-type transport system involved in lipoprotein release permease component
VAA_03207	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VAA_0321	COG2186	Transcriptional regulator
VAA_03211	COG1252	NADH dehydrogenase
VAA_03218	COG0537	adenosine 5'-monophosphoramidase activity
VAA_03224	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VAA_03226	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VAA_03227	COG2226	methyltransferase
VAA_03229	COG0156	8-amino-7-oxononanoate synthase activity
VAA_03231	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VAA_03233	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VAA_03234	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VAA_03236	COG0653	protein targeting
VAA_03237	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VAA_03239	COG4120	Belongs to the binding-protein-dependent transport system permease family
VAA_03241	COG3092	negative regulation of chromosome organization
VAA_03242	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VAA_03243	COG0857	belongs to the CobB CobQ family
VAA_03243	COG0280	phosphate acetyltransferase
VAA_03244	COG0435	Glutathione S-transferase
VAA_03246	COG0444	Belongs to the ABC transporter superfamily
VAA_03247	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAA_03248	COG0601	transmembrane transport
VAA_03253	COG0784	Response regulator, receiver
VAA_03253	COG5002	protein histidine kinase activity
VAA_03259	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VAA_03260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VAA_03264	COG1216	Glycosyl transferase, family 2
VAA_03270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VAA_03271	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VAA_03272	COG1028	Short-chain dehydrogenase reductase Sdr
VAA_03277	COG0800	Aldolase
VAA_03278	COG2610	gluconate transmembrane transporter activity
VAA_03279	COG3265	gluconokinase activity
VAA_03280	COG0129	dihydroxy-acid dehydratase activity
VAA_03281	COG1609	Transcriptional regulator
VAA_03285	COG5002	protein histidine kinase activity
VAA_03285	COG3850	Histidine kinase
VAA_03287	COG2985	domain, Protein
VAA_03291	COG2194	sulfuric ester hydrolase activity
VAA_03292	COG0642	Histidine kinase
VAA_03293	COG0745	RESPONSE REGULATOR receiver
VAA_03295	COG4221	oxidoreductase activity
VAA_03297	COG1022	Amp-dependent synthetase and ligase
VAA_03301	COG3706	GGDEF domain
VAA_03304	COG3126	Type III secretion system lipoprotein chaperone (YscW)
VAA_03305	COG1946	Acyl-CoA thioesterase
VAA_03306	COG1522	sequence-specific DNA binding
VAA_03314	COG1441	menaquinone biosynthetic process
VAA_03315	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VAA_03317	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VAA_03318	COG1169	isochorismate synthase
VAA_03319	COG0436	Aminotransferase
VAA_03321	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VAA_03324	COG0616	signal peptide processing
VAA_03325	COG1028	Short-chain dehydrogenase reductase Sdr
VAA_03326	COG0835	chemotaxis
VAA_03326	COG0784	Response regulator, receiver
VAA_03327	COG1940	carbohydrate kinase activity
VAA_03329	COG4667	esterase of the alpha-beta hydrolase superfamily
VAA_03332	COG0733	neurotransmitter:sodium symporter activity
VAA_03335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VAA_03335	COG1263	PTS System
VAA_03336	COG0084	hydrolase, TatD family'
VAA_03337	COG0470	DNA polymerase III
VAA_03338	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VAA_03339	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VAA_03340	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VAA_03345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VAA_03347	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VAA_03348	COG1399	metal-binding, possibly nucleic acid-binding protein
VAA_03349	COG0424	maF-like protein
VAA_03350	COG0564	pseudouridine synthase activity
VAA_03351	COG1530	ribonuclease E activity
VAA_03354	COG1454	alcohol dehydrogenase
VAA_03354	COG1012	belongs to the aldehyde dehydrogenase family
VAA_03355	COG2095	MarC family integral membrane protein
VAA_03356	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VAA_03357	COG1757	Na H antiporter
VAA_03360	COG3082	Protein of unknown function (DUF1414)
VAA_03361	COG3083	sulfuric ester hydrolase activity
VAA_03362	COG0243	molybdopterin cofactor binding
VAA_03363	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VAA_03366	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VAA_03367	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VAA_03371	COG2853	Lipoprotein
VAA_03374	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VAA_03375	COG1138	Cytochrome C-type biogenesis protein
VAA_03376	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VAA_03378	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VAA_03379	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VAA_03380	COG4133	protoheme IX ABC transporter activity
VAA_03382	COG0835	chemotaxis
VAA_03384	COG1192	Involved in chromosome partitioning
VAA_03385	COG2201	protein-glutamate methylesterase activity
VAA_03386	COG0643	Histidine kinase
VAA_03386	COG2198	Histidine kinase
VAA_03387	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VAA_03390	COG0455	bacterial-type flagellum organization
VAA_03392	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
VAA_03393	COG2062	phosphohistidine phosphatase, SixA
VAA_03394	COG1025	Belongs to the peptidase M16 family
VAA_03395	COG3102	Protein conserved in bacteria
VAA_03400	COG1918	ferrous iron import across plasma membrane
VAA_03402	COG4977	sequence-specific DNA binding
VAA_03405	COG1121	(ABC) transporter
VAA_03406	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VAA_03409	COG0508	dehydrogenase complex catalyzes the overall conversion of
VAA_03410	COG0567	Dehydrogenase, E1 component
VAA_03414	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VAA_03415	COG2009	succinate dehydrogenase
VAA_03418	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VAA_03420	COG0033	Phosphoglucomutase
VAA_03421	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VAA_03422	COG0596	Alpha beta hydrolase
VAA_03424	COG0716	FMN binding
VAA_03425	COG1346	cytolysis
VAA_03427	COG0583	DNA-binding transcription factor activity
VAA_03429	COG0735	belongs to the Fur family
VAA_03430	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VAA_03431	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAA_03432	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VAA_03433	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VAA_03433	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAA_03434	COG0431	NADPH-dependent FMN reductase
VAA_03437	COG3101	peptidyl-lysine hydroxylation
VAA_03438	COG2860	membrane
VAA_03439	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VAA_03441	COG2890	protein-(glutamine-N5) methyltransferase activity
VAA_03442	COG2840	Smr protein MutS2
VAA_03444	COG1684	flagellar biosynthetic protein fliR
VAA_03445	COG1987	bacterial-type flagellum assembly
VAA_03456	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VAA_03459	COG1677	Flagellar hook-basal body complex protein FliE
VAA_03460	COG2204	response regulator
VAA_03461	COG4191	Histidine kinase
VAA_03462	COG2204	response regulator
VAA_03463	COG1516	flagellar protein fliS
VAA_03465	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VAA_03472	COG2837	iron assimilation
VAA_03477	COG1393	Belongs to the ArsC family
VAA_03478	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VAA_03482	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VAA_03485	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VAA_03490	COG4783	chaperone-mediated protein folding
VAA_03491	COG1393	Belongs to the ArsC family
VAA_03495	COG2233	PERMEase
VAA_03496	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VAA_03498	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VAA_03499	COG2912	Transglutaminase-like superfamily
VAA_03500	COG3094	Invasion gene expression up-regulator, SirB
VAA_03501	COG2890	protein-(glutamine-N5) methyltransferase activity
VAA_03502	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VAA_03503	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VAA_03504	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
VAA_03506	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VAA_03508	COG0193	aminoacyl-tRNA hydrolase activity
VAA_03512	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VAA_03514	COG1705	Flagellar rod assembly protein muramidase FlgJ
VAA_03514	COG3951	Flagellar rod assembly protein muramidase FlgJ
VAA_03515	COG1706	bacterial-type flagellum-dependent cell motility
VAA_03516	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VAA_03517	COG4786	Flagellar basal body rod
VAA_03518	COG4787	bacterial-type flagellum-dependent cell motility
VAA_03520	COG1749	Flagellar hook protein flgE
VAA_03521	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
VAA_03522	COG1558	bacterial-type flagellum-dependent cell motility
VAA_03523	COG1815	bacterial-type flagellum-dependent cell motility
VAA_03525	COG0784	Response regulator, receiver
VAA_03525	COG0835	chemotaxis
VAA_03527	COG2747	anti-sigma28 factor FlgM
VAA_03537	COG2217	Heavy metal translocating P-type atpase
VAA_03537	COG2608	mercury ion transmembrane transporter activity
VAA_03541	COG1187	pseudouridine synthase activity
VAA_03542	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VAA_03543	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VAA_03544	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VAA_03546	COG0121	glutamine amidotransferase
VAA_03547	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VAA_03550	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VAA_03552	COG2226	methyltransferase
VAA_03553	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VAA_03554	COG0741	lytic transglycosylase activity
VAA_03554	COG1388	LysM domain
VAA_03557	COG0347	Belongs to the P(II) protein family
VAA_03559	COG0037	tRNA processing
VAA_03561	COG0825	malonyl-CoA metabolic process
VAA_03562	COG0587	DNA-directed DNA polymerase activity
VAA_03564	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VAA_03566	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VAA_03567	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VAA_03568	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VAA_03570	COG0750	zinc metalloprotease
VAA_03571	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VAA_03572	COG0575	Belongs to the CDS family
VAA_03573	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VAA_03574	COG0233	cytoplasmic translational termination
VAA_03576	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VAA_03577	COG0052	Belongs to the universal ribosomal protein uS2 family
VAA_03578	COG0024	Methionine aminopeptidase
VAA_03582	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VAA_03583	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VAA_03589	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VAA_03589	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VAA_03592	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VAA_03593	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VAA_03597	COG2252	PERMEase
VAA_03599	COG2195	Cleaves the N-terminal amino acid of tripeptides
VAA_03600	COG4067	protein conserved in archaea
VAA_03600	COG0189	ligase activity
VAA_03601	COG0189	ligase activity
VAA_03603	COG0733	neurotransmitter:sodium symporter activity
VAA_03605	COG5001	Diguanylate cyclase
VAA_03605	COG2203	Gaf domain
VAA_03605	COG3706	GGDEF domain
VAA_03605	COG4251	negative regulation of phosphorylation
VAA_03607	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VAA_03609	COG1477	protein flavinylation
VAA_03617	COG0271	Belongs to the BolA IbaG family
VAA_03621	COG2211	Major facilitator Superfamily
VAA_03623	COG1595	DNA-templated transcription, initiation
VAA_03626	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VAA_03628	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VAA_03629	COG2166	iron-sulfur cluster assembly
VAA_03630	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VAA_03631	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VAA_03633	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VAA_03633	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VAA_03635	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VAA_03636	COG1074	ATP-dependent DNA helicase activity
VAA_03637	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VAA_03640	COG3141	response to X-ray
VAA_03641	COG2171	N-acyltransferase activity
VAA_03648	COG1609	Transcriptional regulator
VAA_03651	COG1085	galactose-1-phosphate uridylyltransferase
VAA_03652	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VAA_03655	COG0534	Mate efflux family protein
VAA_03658	COG3437	response regulator, receiver
VAA_03658	COG0784	Response regulator, receiver
VAA_03659	COG1022	Amp-dependent synthetase and ligase
VAA_03660	COG4628	conserved protein (DUF2132)
VAA_03662	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VAA_03663	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VAA_03666	COG0560	Phosphoserine phosphatase
VAA_03668	COG0813	purine-nucleoside phosphorylase activity
VAA_03669	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VAA_03671	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VAA_03672	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VAA_03673	COG0084	hydrolase, TatD family'
VAA_03676	COG1115	amino acid carrier protein
VAA_03679	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VAA_03680	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VAA_03681	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VAA_03682	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VAA_03683	COG0083	homoserine kinase activity
VAA_03686	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VAA_03687	COG0745	RESPONSE REGULATOR receiver
VAA_03689	COG5002	protein histidine kinase activity
VAA_03689	COG2198	Histidine kinase
VAA_03689	COG0784	Response regulator, receiver
VAA_03690	COG1242	4 iron, 4 sulfur cluster binding
VAA_03691	COG0067	glutamate synthase
VAA_03691	COG0069	glutamate synthase activity
VAA_03691	COG0070	glutamate synthase
VAA_03693	COG0070	glutamate synthase
VAA_03693	COG0069	glutamate synthase activity
VAA_03693	COG0067	glutamate synthase
VAA_03694	COG0493	'glutamate synthase
VAA_03699	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VAA_03700	COG2860	membrane
VAA_03701	COG0730	response to heat
VAA_03704	COG0505	Belongs to the CarA family
VAA_03707	COG0494	nUDIX hydrolase
VAA_03708	COG0653	protein targeting
VAA_03710	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VAA_03711	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VAA_03712	COG0849	cell division
VAA_03713	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VAA_03715	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VAA_03716	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VAA_03717	COG0772	Belongs to the SEDS family
VAA_03718	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VAA_03719	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VAA_03720	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VAA_03721	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VAA_03722	COG0768	penicillin binding
VAA_03723	COG3116	cell division
VAA_03726	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VAA_03728	COG3107	peptidoglycan biosynthetic process
VAA_03730	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VAA_03732	COG2969	positive regulation of protein catabolic process
VAA_03733	COG0625	glutathione transferase activity
VAA_03734	COG2857	Cytochrome c1
VAA_03735	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VAA_03736	COG0723	plastoquinol--plastocyanin reductase activity
VAA_03739	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VAA_03740	COG3105	Protein conserved in bacteria
VAA_03741	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VAA_03742	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VAA_03743	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VAA_03744	COG0187	DNA topoisomerase II activity
VAA_03745	COG3150	esterase
VAA_03747	COG3151	Protein conserved in bacteria
VAA_03748	COG0494	nUDIX hydrolase
VAA_03750	COG1538	Outer membrane efflux protein
VAA_03752	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VAA_03753	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VAA_03756	COG3025	triphosphatase activity
VAA_03758	COG1392	Phosphate transport regulator
VAA_03759	COG0306	phosphate transporter
VAA_03760	COG4991	sh3 domain protein
VAA_03762	COG3267	Type II secretory pathway component ExeA
VAA_03762	COG3409	Peptidoglycan-binding domain 1 protein
VAA_03763	COG0617	tRNA 3'-terminal CCA addition
VAA_03765	COG0504	CTP synthase activity
VAA_03766	COG3956	TIGRFAM MazG family protein
VAA_03767	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VAA_03768	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VAA_03770	COG4999	Histidine kinase
VAA_03770	COG3850	Histidine kinase
VAA_03770	COG3437	response regulator, receiver
VAA_03770	COG2205	protein histidine kinase activity
VAA_03771	COG0736	holo-[acyl-carrier-protein] synthase activity
VAA_03776	COG0681	Belongs to the peptidase S26 family
VAA_03777	COG0481	GTPase activity
VAA_03778	COG3086	response to oxidative stress
VAA_03781	COG1595	DNA-templated transcription, initiation
VAA_03782	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VAA_03784	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VAA_03785	COG0354	folic acid binding
VAA_03788	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAA_03789	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAA_03791	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VAA_03792	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VAA_03794	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAA_03796	COG0028	Belongs to the TPP enzyme family
VAA_03797	COG1022	Amp-dependent synthetase and ligase
VAA_03798	COG0583	DNA-binding transcription factor activity
VAA_03801	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VAA_03802	COG0473	3-isopropylmalate dehydrogenase activity
VAA_03804	COG0066	3-isopropylmalate dehydratase activity
VAA_03885	COG3754	Rhamnan synthesis protein F
VAA_03891	COG2433	Pfam Transposase IS66
VAA_03908	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAA_03919	COG2433	Pfam Transposase IS66
VAA_03922	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAA_03941	COG2801	Transposase and inactivated derivatives
VAA_03946	COG2433	Pfam Transposase IS66
VAA_03949	COG2433	Pfam Transposase IS66
VAA_03967	COG2433	Pfam Transposase IS66
VAA_03971	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VAA_03982	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VAA_04033	COG4372	Transposase
VAA_04035	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VAA_04051	COG2433	Pfam Transposase IS66
VAA_04060	COG2433	Pfam Transposase IS66
VAA_04065	COG2433	Pfam Transposase IS66
VAA_04068	COG3422	double-strand break repair
VAA_04071	COG2433	Pfam Transposase IS66
VAA_04257	COG2433	Pfam Transposase IS66
VAA_04277	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VAA_04285	COG3140	Belongs to the UPF0181 family
VAA_04288	COG0745	RESPONSE REGULATOR receiver
VAA_04290	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VAA_04291	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VAA_04294	COG3706	GGDEF domain
VAA_04295	COG1278	Cold shock
VAA_04296	COG0840	transmembrane signaling receptor activity
VAA_04299	COG2501	S4 domain
VAA_04300	COG0625	glutathione transferase activity
VAA_04303	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VAA_04304	COG0488	(ABC) transporter
VAA_04307	COG2050	protein possibly involved in aromatic compounds catabolism
VAA_04309	COG2824	Alkylphosphonate utilization operon protein PhnA
VAA_04312	COG1609	Transcriptional regulator
VAA_04313	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VAA_04314	COG1879	ABC-type sugar transport system periplasmic component
VAA_04315	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAA_04316	COG1129	ABC transporter
VAA_04317	COG1869	D-ribose catabolic process
VAA_04320	COG2433	Pfam Transposase IS66
VAA_04322	COG1187	pseudouridine synthase activity
VAA_0520	COG1959	2 iron, 2 sulfur cluster binding
VAA_0986	COG0861	Integral membrane protein TerC family
VAA_1488	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VAA_1806	COG1793	dna ligase
VAA_1856	COG1067	ATP-dependent peptidase activity
VAA_3171	COG3012	SEC-C Motif Domain Protein
VAA_3196	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VAA_3320	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates