locus-tag	class	description
L2O48_00015	COG0582	viral genome integration into host DNA
L2O48_00030	COG0784	Response regulator, receiver
L2O48_00030	COG5002	protein histidine kinase activity
L2O48_00050	COG2433	Pfam Transposase IS66
L2O48_00055	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L2O48_00060	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
L2O48_00065	COG2885	chlorophyll binding
L2O48_00070	COG0823	Involved in the tonB-independent uptake of proteins
L2O48_00085	COG0811	peptide transport
L2O48_00090	COG0824	Thioesterase
L2O48_00095	COG3790	cyd operon protein YbgE
L2O48_00100	COG4890	Cyd operon protein YbgT
L2O48_00105	COG1294	oxidase, subunit
L2O48_00110	COG1271	oxidase subunit
L2O48_00115	COG2255	four-way junction helicase activity
L2O48_00120	COG0632	four-way junction helicase activity
L2O48_00125	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
L2O48_00130	COG0215	cysteine-tRNA ligase activity
L2O48_00135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L2O48_00140	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2O48_00145	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
L2O48_00150	COG3012	SEC-C Motif Domain Protein
L2O48_00160	COG1199	ATP-dependent helicase activity
L2O48_00170	COG3923	Primosomal replication protein n
L2O48_00180	COG0840	transmembrane signaling receptor activity
L2O48_00185	COG0708	Exodeoxyribonuclease III
L2O48_00190	COG4160	amino acid transport
L2O48_00215	COG1882	Formate acetyltransferase
L2O48_00230	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L2O48_00240	COG3013	Belongs to the UPF0304 family
L2O48_00245	COG2766	serine protein kinase
L2O48_00250	COG2718	Belongs to the UPF0229 family
L2O48_00255	COG2719	SpoVR family
L2O48_00265	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
L2O48_00280	COG1132	(ABC) transporter
L2O48_00285	COG0658	competence protein
L2O48_00285	COG2333	competence protein COMEC
L2O48_00295	COG4591	ABC-type transport system involved in lipoprotein release permease component
L2O48_00300	COG1136	(ABC) transporter
L2O48_00305	COG4591	ABC-type transport system involved in lipoprotein release permease component
L2O48_00315	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L2O48_00330	COG1252	NADH dehydrogenase
L2O48_00335	COG3150	esterase
L2O48_00360	COG0537	adenosine 5'-monophosphoramidase activity
L2O48_00375	COG2186	Transcriptional regulator
L2O48_00380	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L2O48_00390	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
L2O48_00395	COG2226	methyltransferase
L2O48_00400	COG0156	8-amino-7-oxononanoate synthase activity
L2O48_00405	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
L2O48_00410	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L2O48_00420	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L2O48_00425	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L2O48_00430	COG0653	protein targeting
L2O48_00435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2O48_00445	COG4120	Belongs to the binding-protein-dependent transport system permease family
L2O48_00455	COG3092	negative regulation of chromosome organization
L2O48_00460	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L2O48_00465	COG0857	belongs to the CobB CobQ family
L2O48_00465	COG0280	phosphate acetyltransferase
L2O48_00470	COG0435	Glutathione S-transferase
L2O48_00480	COG0444	Belongs to the ABC transporter superfamily
L2O48_00485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2O48_00490	COG0601	transmembrane transport
L2O48_00505	COG5002	protein histidine kinase activity
L2O48_00505	COG0784	Response regulator, receiver
L2O48_00530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2O48_00535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2O48_00555	COG1216	Glycosyl transferase, family 2
L2O48_00585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L2O48_00590	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L2O48_00595	COG1028	Short-chain dehydrogenase reductase Sdr
L2O48_00620	COG0800	Aldolase
L2O48_00625	COG2610	gluconate transmembrane transporter activity
L2O48_00630	COG3265	gluconokinase activity
L2O48_00635	COG0129	dihydroxy-acid dehydratase activity
L2O48_00640	COG1609	Transcriptional regulator
L2O48_00655	COG3850	Histidine kinase
L2O48_00655	COG5002	protein histidine kinase activity
L2O48_00665	COG2985	domain, Protein
L2O48_00680	COG2194	sulfuric ester hydrolase activity
L2O48_00685	COG0642	Histidine kinase
L2O48_00690	COG0745	RESPONSE REGULATOR receiver
L2O48_00700	COG4221	oxidoreductase activity
L2O48_00710	COG1022	Amp-dependent synthetase and ligase
L2O48_00735	COG3706	GGDEF domain
L2O48_00750	COG3126	Type III secretion system lipoprotein chaperone (YscW)
L2O48_00755	COG1946	Acyl-CoA thioesterase
L2O48_00760	COG1522	sequence-specific DNA binding
L2O48_00810	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
L2O48_00820	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
L2O48_00825	COG1169	isochorismate synthase
L2O48_00830	COG0436	Aminotransferase
L2O48_00835	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
L2O48_00840	COG0232	Belongs to the dGTPase family. Type 2 subfamily
L2O48_00855	COG0616	signal peptide processing
L2O48_00860	COG1028	Short-chain dehydrogenase reductase Sdr
L2O48_00865	COG0784	Response regulator, receiver
L2O48_00865	COG0835	chemotaxis
L2O48_00870	COG1940	carbohydrate kinase activity
L2O48_00880	COG4667	esterase of the alpha-beta hydrolase superfamily
L2O48_00895	COG0733	neurotransmitter:sodium symporter activity
L2O48_00905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L2O48_00905	COG1263	PTS System
L2O48_00910	COG0084	hydrolase, TatD family'
L2O48_00915	COG0470	DNA polymerase III
L2O48_00920	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L2O48_00925	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L2O48_00930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2O48_00955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L2O48_00970	COG1399	metal-binding, possibly nucleic acid-binding protein
L2O48_00975	COG0424	maF-like protein
L2O48_00980	COG0564	pseudouridine synthase activity
L2O48_00985	COG1530	ribonuclease E activity
L2O48_00995	COG1012	belongs to the aldehyde dehydrogenase family
L2O48_00995	COG1454	alcohol dehydrogenase
L2O48_01000	COG2095	MarC family integral membrane protein
L2O48_01005	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L2O48_01010	COG1757	Na H antiporter
L2O48_01025	COG3082	Protein of unknown function (DUF1414)
L2O48_01030	COG3083	sulfuric ester hydrolase activity
L2O48_01040	COG0243	molybdopterin cofactor binding
L2O48_01045	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L2O48_01060	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L2O48_01065	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L2O48_01085	COG2853	Lipoprotein
L2O48_01100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L2O48_01105	COG1138	Cytochrome C-type biogenesis protein
L2O48_01110	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
L2O48_01120	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L2O48_01125	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L2O48_01130	COG4133	protoheme IX ABC transporter activity
L2O48_01140	COG0835	chemotaxis
L2O48_01150	COG1192	Involved in chromosome partitioning
L2O48_01155	COG2201	protein-glutamate methylesterase activity
L2O48_01160	COG0643	Histidine kinase
L2O48_01160	COG0784	Response regulator, receiver
L2O48_01160	COG2198	Histidine kinase
L2O48_01165	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
L2O48_01190	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L2O48_01195	COG2062	phosphohistidine phosphatase, SixA
L2O48_01200	COG1025	Belongs to the peptidase M16 family
L2O48_01205	COG3102	Protein conserved in bacteria
L2O48_01230	COG1918	ferrous iron import across plasma membrane
L2O48_01235	COG4977	sequence-specific DNA binding
L2O48_01240	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
L2O48_01245	COG1121	(ABC) transporter
L2O48_01250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L2O48_01265	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2O48_01270	COG0567	Dehydrogenase, E1 component
L2O48_01285	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L2O48_01300	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L2O48_01310	COG0033	Phosphoglucomutase
L2O48_01315	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
L2O48_01320	COG0596	Alpha beta hydrolase
L2O48_01335	COG1346	cytolysis
L2O48_01345	COG0583	DNA-binding transcription factor activity
L2O48_01355	COG0735	belongs to the Fur family
L2O48_01360	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L2O48_01365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L2O48_01370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L2O48_01375	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L2O48_01375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2O48_01380	COG0431	NADPH-dependent FMN reductase
L2O48_01390	COG3101	peptidyl-lysine hydroxylation
L2O48_01395	COG2860	membrane
L2O48_01400	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
L2O48_01405	COG2890	protein-(glutamine-N5) methyltransferase activity
L2O48_01410	COG2840	Smr protein MutS2
L2O48_01420	COG1684	flagellar biosynthetic protein fliR
L2O48_01425	COG1987	bacterial-type flagellum assembly
L2O48_01475	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L2O48_01485	COG1677	Flagellar hook-basal body complex protein FliE
L2O48_01505	COG1516	flagellar protein fliS
L2O48_01515	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
L2O48_01540	COG2837	iron assimilation
L2O48_01565	COG1393	Belongs to the ArsC family
L2O48_01585	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
L2O48_01600	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L2O48_01620	COG4783	chaperone-mediated protein folding
L2O48_01625	COG1393	Belongs to the ArsC family
L2O48_01645	COG2233	PERMEase
L2O48_01650	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L2O48_01660	COG2877	3-deoxy-8-phosphooctulonate synthase activity
L2O48_01665	COG2912	Transglutaminase-like superfamily
L2O48_01670	COG3094	Invasion gene expression up-regulator, SirB
L2O48_01675	COG2890	protein-(glutamine-N5) methyltransferase activity
L2O48_01680	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
L2O48_01685	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
L2O48_01690	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L2O48_01700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2O48_01705	COG0193	aminoacyl-tRNA hydrolase activity
L2O48_01795	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
L2O48_01805	COG3951	Flagellar rod assembly protein muramidase FlgJ
L2O48_01805	COG1705	Flagellar rod assembly protein muramidase FlgJ
L2O48_01810	COG1706	bacterial-type flagellum-dependent cell motility
L2O48_01815	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
L2O48_01825	COG4787	bacterial-type flagellum-dependent cell motility
L2O48_01830	COG1749	Flagellar hook protein flgE
L2O48_01845	COG1815	bacterial-type flagellum-dependent cell motility
L2O48_01855	COG0784	Response regulator, receiver
L2O48_01855	COG0835	chemotaxis
L2O48_01865	COG2747	anti-sigma28 factor FlgM
L2O48_01910	COG2217	Heavy metal translocating P-type atpase
L2O48_01910	COG2608	mercury ion transmembrane transporter activity
L2O48_01935	COG1187	pseudouridine synthase activity
L2O48_01940	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
L2O48_01945	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
L2O48_01950	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L2O48_01955	COG0121	glutamine amidotransferase
L2O48_01960	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
L2O48_01980	COG0328	RNA-DNA hybrid ribonuclease activity
L2O48_01985	COG2226	methyltransferase
L2O48_01990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2O48_01995	COG0741	lytic transglycosylase activity
L2O48_01995	COG1388	LysM domain
L2O48_02005	COG3021	interspecies interaction between organisms
L2O48_02010	COG0347	Belongs to the P(II) protein family
L2O48_02020	COG0037	tRNA processing
L2O48_02025	COG0825	malonyl-CoA metabolic process
L2O48_02030	COG0587	DNA-directed DNA polymerase activity
L2O48_02040	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2O48_02050	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L2O48_02055	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2O48_02060	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
L2O48_02070	COG0750	zinc metalloprotease
L2O48_02075	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
L2O48_02080	COG0575	Belongs to the CDS family
L2O48_02085	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L2O48_02090	COG0233	cytoplasmic translational termination
L2O48_02100	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
L2O48_02105	COG0052	Belongs to the universal ribosomal protein uS2 family
L2O48_02110	COG0024	Methionine aminopeptidase
L2O48_02115	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
L2O48_02125	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L2O48_02130	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L2O48_02135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L2O48_02155	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2O48_02155	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2O48_02160	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
L2O48_02165	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
L2O48_02170	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
L2O48_02180	COG1073	alpha beta
L2O48_02185	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
L2O48_02190	COG2252	PERMEase
L2O48_02195	COG2195	Cleaves the N-terminal amino acid of tripeptides
L2O48_02200	COG4067	protein conserved in archaea
L2O48_02200	COG0189	ligase activity
L2O48_02205	COG0189	ligase activity
L2O48_02215	COG0733	neurotransmitter:sodium symporter activity
L2O48_02230	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2O48_02240	COG1477	protein flavinylation
L2O48_02275	COG0271	Belongs to the BolA IbaG family
L2O48_02295	COG2211	Major facilitator Superfamily
L2O48_02305	COG1595	DNA-templated transcription, initiation
L2O48_02320	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
L2O48_02330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L2O48_02335	COG2166	iron-sulfur cluster assembly
L2O48_02340	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L2O48_02345	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
L2O48_02355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L2O48_02355	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
L2O48_02365	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2O48_02370	COG1074	ATP-dependent DNA helicase activity
L2O48_02375	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L2O48_02390	COG3141	response to X-ray
L2O48_02395	COG2171	N-acyltransferase activity
L2O48_02425	COG1609	Transcriptional regulator
L2O48_02430	COG2017	converts alpha-aldose to the beta-anomer
L2O48_02440	COG1085	galactose-1-phosphate uridylyltransferase
L2O48_02445	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2O48_02460	COG3437	response regulator, receiver
L2O48_02460	COG0784	Response regulator, receiver
L2O48_02465	COG1022	Amp-dependent synthetase and ligase
L2O48_02470	COG4628	conserved protein (DUF2132)
L2O48_02475	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L2O48_02480	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
L2O48_02490	COG0560	Phosphoserine phosphatase
L2O48_02500	COG0813	purine-nucleoside phosphorylase activity
L2O48_02505	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
L2O48_02510	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
L2O48_02515	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
L2O48_02520	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L2O48_02525	COG0084	hydrolase, TatD family'
L2O48_02535	COG3022	response to hydroperoxide
L2O48_02540	COG1115	amino acid carrier protein
L2O48_02555	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
L2O48_02560	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
L2O48_02565	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
L2O48_02570	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L2O48_02575	COG0083	homoserine kinase activity
L2O48_02595	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2O48_02600	COG0745	RESPONSE REGULATOR receiver
L2O48_02610	COG5002	protein histidine kinase activity
L2O48_02610	COG2198	Histidine kinase
L2O48_02610	COG0784	Response regulator, receiver
L2O48_02615	COG1242	4 iron, 4 sulfur cluster binding
L2O48_02620	COG0070	glutamate synthase
L2O48_02620	COG0069	glutamate synthase activity
L2O48_02620	COG0067	glutamate synthase
L2O48_02630	COG0070	glutamate synthase
L2O48_02630	COG0069	glutamate synthase activity
L2O48_02630	COG0067	glutamate synthase
L2O48_02635	COG0493	'glutamate synthase
L2O48_02645	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L2O48_02655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L2O48_02660	COG2860	membrane
L2O48_02665	COG0583	DNA-binding transcription factor activity
L2O48_02670	COG0730	response to heat
L2O48_02675	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
L2O48_02680	COG0505	Belongs to the CarA family
L2O48_02685	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
L2O48_02690	COG0494	nUDIX hydrolase
L2O48_02695	COG0653	protein targeting
L2O48_02705	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
L2O48_02710	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L2O48_02715	COG0849	cell division
L2O48_02720	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L2O48_02725	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L2O48_02730	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L2O48_02735	COG0772	Belongs to the SEDS family
L2O48_02740	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
L2O48_02750	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L2O48_02755	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L2O48_02760	COG0768	penicillin binding
L2O48_02765	COG3116	cell division
L2O48_02770	COG0275	rRNA processing
L2O48_02780	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
L2O48_02785	COG3107	peptidoglycan biosynthetic process
L2O48_02790	COG0792	nuclease activity
L2O48_02795	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
L2O48_02805	COG2969	positive regulation of protein catabolic process
L2O48_02810	COG0625	glutathione transferase activity
L2O48_02815	COG2857	Cytochrome c1
L2O48_02820	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
L2O48_02825	COG0723	plastoquinol--plastocyanin reductase activity
L2O48_02835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
L2O48_02840	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L2O48_02845	COG3105	Protein conserved in bacteria
L2O48_02850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2O48_02855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2O48_02860	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L2O48_02865	COG0187	DNA topoisomerase II activity
L2O48_02870	COG3150	esterase
L2O48_02880	COG3151	Protein conserved in bacteria
L2O48_02885	COG0494	nUDIX hydrolase
L2O48_02890	COG1538	Outer membrane efflux protein
L2O48_02900	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L2O48_02910	COG3025	triphosphatase activity
L2O48_02915	COG1392	Phosphate transport regulator
L2O48_02920	COG0306	phosphate transporter
L2O48_02925	COG4991	sh3 domain protein
L2O48_02935	COG3409	Peptidoglycan-binding domain 1 protein
L2O48_02935	COG3267	Type II secretory pathway component ExeA
L2O48_02940	COG0617	tRNA 3'-terminal CCA addition
L2O48_02950	COG0504	CTP synthase activity
L2O48_02955	COG3956	TIGRFAM MazG family protein
L2O48_02960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2O48_02965	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L2O48_02970	COG4999	Histidine kinase
L2O48_02970	COG3437	response regulator, receiver
L2O48_02970	COG3850	Histidine kinase
L2O48_02970	COG2205	protein histidine kinase activity
L2O48_02975	COG0736	holo-[acyl-carrier-protein] synthase activity
L2O48_02980	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L2O48_02985	COG1381	Involved in DNA repair and RecF pathway recombination
L2O48_02990	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L2O48_02995	COG0571	ribonuclease III activity
L2O48_03005	COG0481	GTPase activity
L2O48_03010	COG3086	response to oxidative stress
L2O48_03025	COG1595	DNA-templated transcription, initiation
L2O48_03030	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
L2O48_03040	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L2O48_03055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2O48_03060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2O48_03065	COG3079	Belongs to the UPF0149 family
L2O48_03070	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
L2O48_03080	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L2O48_03090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L2O48_03100	COG0028	Belongs to the TPP enzyme family
L2O48_03105	COG1022	Amp-dependent synthetase and ligase
L2O48_03110	COG0583	DNA-binding transcription factor activity
L2O48_03130	COG0473	3-isopropylmalate dehydrogenase activity
L2O48_03140	COG0066	3-isopropylmalate dehydratase activity
L2O48_03230	COG0795	lipopolysaccharide-transporting ATPase activity
L2O48_03235	COG0795	lipopolysaccharide-transporting ATPase activity
L2O48_03240	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L2O48_03245	COG2927	DNA polymerase III (CHI subunit)
L2O48_03250	COG0525	valine-tRNA ligase activity
L2O48_03255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L2O48_03260	COG0564	pseudouridine synthase activity
L2O48_03270	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L2O48_03275	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
L2O48_03290	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
L2O48_03295	COG0251	oxidation-reduction process
L2O48_03310	COG0204	Acyl-transferase
L2O48_03315	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L2O48_03320	COG5007	Belongs to the BolA IbaG family
L2O48_03330	COG2854	intermembrane phospholipid transfer
L2O48_03335	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L2O48_03340	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L2O48_03345	COG1127	ABC transporter
L2O48_03355	COG0517	IMP dehydrogenase activity
L2O48_03355	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L2O48_03360	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L2O48_03370	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L2O48_03375	COG1137	ATPase activity
L2O48_03385	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
L2O48_03390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2O48_03395	COG1660	Displays ATPase and GTPase activities
L2O48_03400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2O48_03405	COG2239	Acts as a magnesium transporter
L2O48_03410	COG0312	modulator of DNA gyrase
L2O48_03415	COG3028	Belongs to the UPF0307 family
L2O48_03420	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
L2O48_03425	COG1178	ABC-type Fe3 transport system permease component
L2O48_03435	COG0163	prenyltransferase activity
L2O48_03440	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L2O48_03445	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
L2O48_03450	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L2O48_03455	COG2105	PFAM AIG2 family protein
L2O48_03460	COG2911	Protein conserved in bacteria
L2O48_03465	COG0729	surface antigen
L2O48_03470	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L2O48_03475	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
L2O48_03510	COG0529	Catalyzes the synthesis of activated sulfate
L2O48_03515	COG2895	sulfate adenylyltransferase (ATP) activity
L2O48_03520	COG0175	sulfate reduction
L2O48_03525	COG1648	precorrin-2 dehydrogenase activity
L2O48_03525	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L2O48_03530	COG0737	Belongs to the 5'-nucleotidase family
L2O48_03570	COG0513	Belongs to the DEAD box helicase family
L2O48_03575	COG2153	protein acetylation
L2O48_03580	COG3061	Opacity-associated protein A
L2O48_03580	COG3266	domain, Protein
L2O48_03585	COG0545	Peptidyl-prolyl cis-trans isomerase
L2O48_03590	COG0203	ribosomal protein L17
L2O48_03595	COG0202	RNA polymerase activity
L2O48_03600	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
L2O48_03605	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
L2O48_03610	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
L2O48_03615	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L2O48_03620	COG0201	protein transport
L2O48_03625	COG0200	Binds to the 23S rRNA
L2O48_03630	COG1841	ribosomal large subunit assembly
L2O48_03635	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
L2O48_03645	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
L2O48_03650	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
L2O48_03655	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
L2O48_03660	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
L2O48_03665	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
L2O48_03675	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
L2O48_03685	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
L2O48_03700	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
L2O48_03705	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
L2O48_03715	COG0088	Forms part of the polypeptide exit tunnel
L2O48_03720	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
L2O48_03725	COG0051	transcription antitermination factor activity, RNA binding
L2O48_03730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2O48_03735	COG0557	exoribonuclease II activity
L2O48_03740	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
L2O48_03745	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L2O48_03755	COG1047	Peptidyl-prolyl cis-trans
L2O48_03760	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
L2O48_03770	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2O48_03775	COG0488	(ABC) transporter
L2O48_03785	COG0429	hydrolase of the alpha beta-hydrolase fold
L2O48_03795	COG3954	Phosphoribulokinase
L2O48_03800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2O48_03810	COG1012	belongs to the aldehyde dehydrogenase family
L2O48_03820	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2O48_03835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2O48_03845	COG0583	DNA-binding transcription factor activity
L2O48_03860	COG0180	Tryptophanyl-tRNA synthetase
L2O48_03865	COG0546	phosphoglycolate phosphatase activity
L2O48_03870	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L2O48_03875	COG0338	D12 class N6 adenine-specific DNA methyltransferase
L2O48_03885	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
L2O48_03890	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L2O48_03920	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
L2O48_03930	COG0678	peroxiredoxin activity
L2O48_03930	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L2O48_03935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2O48_03945	COG0165	Argininosuccinate lyase
L2O48_03945	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
L2O48_03950	COG0137	argininosuccinate synthase activity
L2O48_03955	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L2O48_03960	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
L2O48_03965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L2O48_03970	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
L2O48_03980	COG1045	serine acetyltransferase
L2O48_03985	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
L2O48_03995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L2O48_04000	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L2O48_04005	COG1053	succinate dehydrogenase
L2O48_04010	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L2O48_04015	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
L2O48_04025	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
L2O48_04030	COG1509	lysine 2,3-aminomutase activity
L2O48_04045	COG0459	protein refolding
L2O48_04050	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
L2O48_04080	COG0534	Mate efflux family protein
L2O48_04085	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2O48_04090	COG1575	Belongs to the MenA family. Type 1 subfamily
L2O48_04095	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
L2O48_04100	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
L2O48_04110	COG1609	Transcriptional regulator
L2O48_04115	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L2O48_04125	COG0281	malic enzyme
L2O48_04135	COG0626	cystathionine gamma-synthase activity
L2O48_04140	COG0527	aspartate kinase activity
L2O48_04140	COG0460	homoserine dehydrogenase
L2O48_04145	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L2O48_04150	COG3074	FtsZ-dependent cytokinesis
L2O48_04155	COG1494	fructose-1,6-bisphosphatase
L2O48_04160	COG0205	6-phosphofructokinase activity
L2O48_04165	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
L2O48_04175	COG0745	RESPONSE REGULATOR receiver
L2O48_04180	COG2205	protein histidine kinase activity
L2O48_04185	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L2O48_04190	COG1278	Cold shock
L2O48_04195	COG3030	protein affecting phage T7 exclusion by the F plasmid
L2O48_04200	COG1027	Aspartate ammonia-lyase
L2O48_04205	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
L2O48_04210	COG1288	antiporter activity
L2O48_04220	COG0549	Belongs to the carbamate kinase family
L2O48_04225	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
L2O48_04230	COG0540	Belongs to the ATCase OTCase family
L2O48_04235	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
L2O48_04240	COG1438	arginine binding
L2O48_04245	COG4232	protein-disulfide reductase activity
L2O48_04265	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2O48_04270	COG0784	Response regulator, receiver
L2O48_04270	COG2198	Histidine kinase
L2O48_04270	COG2205	protein histidine kinase activity
L2O48_04275	COG2814	Major facilitator Superfamily
L2O48_04290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2O48_04295	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
L2O48_04300	COG0511	ligase activity, forming carbon-carbon bonds
L2O48_04305	COG0439	Biotin carboxylase
L2O48_04310	COG2264	protein methyltransferase activity
L2O48_04315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2O48_04320	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
L2O48_04330	COG0789	Transcriptional regulator
L2O48_04335	COG0138	bifunctional purine biosynthesis protein purh
L2O48_04340	COG0151	Belongs to the GarS family
L2O48_04350	COG0776	regulation of translation
L2O48_04355	COG1253	flavin adenine dinucleotide binding
L2O48_04360	COG2852	Protein conserved in bacteria
L2O48_04365	COG3068	Protein conserved in bacteria
L2O48_04370	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L2O48_04375	COG0668	transmembrane transport
L2O48_04385	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
L2O48_04390	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L2O48_04405	COG0438	transferase activity, transferring glycosyl groups
L2O48_04410	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L2O48_04445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2O48_04450	COG1596	polysaccharide export
L2O48_04470	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2O48_04480	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L2O48_04505	COG3754	Rhamnan synthesis protein F
L2O48_04535	COG0463	Glycosyl transferase, family 2
L2O48_04540	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L2O48_04550	COG0028	Belongs to the TPP enzyme family
L2O48_04595	COG1682	transport, permease protein
L2O48_04620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2O48_04630	COG3307	-O-antigen
L2O48_04635	COG0859	PFAM glycosyl transferase family 9
L2O48_04650	COG1519	Transferase
L2O48_04660	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L2O48_04675	COG3642	lipopolysaccharide core region biosynthetic process
L2O48_04680	COG0859	PFAM glycosyl transferase family 9
L2O48_04685	COG0463	Glycosyl transferase, family 2
L2O48_04690	COG0859	PFAM glycosyl transferase family 9
L2O48_04695	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
L2O48_04700	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L2O48_04710	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L2O48_04715	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L2O48_04720	COG2003	Belongs to the UPF0758 family
L2O48_04725	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L2O48_04730	COG1309	transcriptional regulator
L2O48_04735	COG1560	Kdo2-lipid A biosynthetic process
L2O48_04740	COG1560	Kdo2-lipid A biosynthetic process
L2O48_04745	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
L2O48_04750	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
L2O48_04755	COG1561	YicC-like family, N-terminal region
L2O48_04840	COG2433	Pfam Transposase IS66
L2O48_04865	COG2433	Pfam Transposase IS66
L2O48_04890	COG2433	Pfam Transposase IS66
L2O48_04915	COG0612	Peptidase, M16
L2O48_04940	COG1120	ATPase activity
L2O48_04945	COG4774	siderophore transport
L2O48_04950	COG1132	(ABC) transporter
L2O48_04955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L2O48_04955	COG1263	PTS System
L2O48_04960	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
L2O48_04980	COG0514	ATP-dependent DNA helicase (RecQ)
L2O48_04985	COG2962	Rard protein
L2O48_04995	COG1280	lysine exporter protein (LysE YggA)
L2O48_05000	COG0210	DNA helicase
L2O48_05005	COG0339	signal peptide processing
L2O48_05010	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L2O48_05015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2O48_05050	COG5290	Psort location Cytoplasmic, score
L2O48_05060	COG2433	Pfam Transposase IS66
L2O48_05080	COG3081	Nucleoid-associated protein
L2O48_05095	COG2433	Pfam Transposase IS66
L2O48_05150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2O48_05155	COG0601	transmembrane transport
L2O48_05205	COG1309	transcriptional regulator
L2O48_05210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2O48_05215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2O48_05220	COG2960	long-chain fatty acid transporting porin activity
L2O48_05225	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L2O48_05245	COG3078	GTPase activator activity
L2O48_05265	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L2O48_05265	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L2O48_05275	COG0084	hydrolase, TatD family'
L2O48_05280	COG0805	protein transport
L2O48_05285	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L2O48_05290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L2O48_05295	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L2O48_05305	COG2226	methyltransferase
L2O48_05310	COG1322	Protein conserved in bacteria
L2O48_05330	COG2160	L-arabinose isomerase activity
L2O48_05340	COG1069	ribulokinase activity
L2O48_05345	COG1879	ABC-type sugar transport system periplasmic component
L2O48_05350	COG1129	ABC transporter
L2O48_05355	COG1172	Belongs to the binding-protein-dependent transport system permease family
L2O48_05365	COG2081	HI0933 family
L2O48_05380	COG1528	Iron-storage protein
L2O48_05385	COG0589	response to stress
L2O48_05400	COG0742	ribosomal rna small subunit methyltransferase
L2O48_05405	COG1522	sequence-specific DNA binding
L2O48_05430	COG0006	proline dipeptidase activity
L2O48_05430	COG0006	proline dipeptidase activity
L2O48_05435	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
L2O48_05440	COG2022	thiamine diphosphate biosynthetic process
L2O48_05445	COG2104	thiamine diphosphate biosynthetic process
L2O48_05455	COG0352	thiamine-phosphate diphosphorylase activity
L2O48_05460	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
L2O48_05510	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
L2O48_05515	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L2O48_05520	COG1739	Uncharacterized protein family UPF0029
L2O48_05530	COG0183	Belongs to the thiolase family
L2O48_05535	COG0583	DNA-binding transcription factor activity
L2O48_05540	COG2814	Major facilitator Superfamily
L2O48_05550	COG0355	proton-transporting ATP synthase activity, rotational mechanism
L2O48_05555	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
L2O48_05560	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
L2O48_05565	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
L2O48_05570	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L2O48_05575	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
L2O48_05590	COG3312	ion transport
L2O48_05595	COG1475	DNA binding
L2O48_05600	COG1192	Involved in chromosome partitioning
L2O48_05610	COG0445	tRNA wobble uridine modification
L2O48_05615	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L2O48_05625	COG0706	membrane insertase activity
L2O48_05645	COG1126	abc transporter atp-binding protein
L2O48_05665	COG0592	DNA-directed DNA polymerase activity
L2O48_05670	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L2O48_05675	COG0187	DNA topoisomerase II activity
L2O48_05685	COG0071	Belongs to the small heat shock protein (HSP20) family
L2O48_05690	COG3977	Valine--pyruvate aminotransferase
L2O48_05700	COG0752	glycyl-tRNA synthetase alpha subunit
L2O48_05705	COG2119	membrane
L2O48_05715	COG0425	Belongs to the sulfur carrier protein TusA family
L2O48_05730	COG0604	alcohol dehydrogenase
L2O48_05745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2O48_05750	COG3978	acetolactate synthase activity
L2O48_05830	COG2433	Pfam Transposase IS66
L2O48_05850	COG2433	Pfam Transposase IS66
L2O48_05860	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2O48_05865	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L2O48_05875	COG3084	Protein conserved in bacteria
L2O48_05885	COG1272	protein, Hemolysin III
L2O48_05895	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L2O48_05900	COG0569	domain protein
L2O48_05905	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L2O48_05905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L2O48_05910	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L2O48_05915	COG0242	peptide deformylase activity
L2O48_05920	COG1652	LysM domain
L2O48_05925	COG0758	DNA mediated transformation
L2O48_05930	COG2922	Belongs to the Smg family
L2O48_05935	COG0551	DNA topoisomerase type I activity
L2O48_05940	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L2O48_05945	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
L2O48_05950	COG0009	L-threonylcarbamoyladenylate synthase
L2O48_05955	COG0408	coproporphyrinogen oxidase activity
L2O48_05960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L2O48_05970	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L2O48_06005	COG3071	HemY protein
L2O48_06010	COG2959	enzyme of heme biosynthesis
L2O48_06015	COG1587	Uroporphyrinogen-III synthase
L2O48_06040	COG0019	diaminopimelate decarboxylase activity
L2O48_06045	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
L2O48_06055	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L2O48_06060	COG1011	Hydrolase
L2O48_06065	COG3148	PFAM DTW domain containing protein
L2O48_06075	COG0561	phosphatase activity
L2O48_06080	COG2267	carboxylic ester hydrolase activity
L2O48_06085	COG1280	lysine exporter protein (LysE YggA)
L2O48_06090	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
L2O48_06095	COG0783	Belongs to the Dps family
L2O48_06135	COG2433	Pfam Transposase IS66
L2O48_06180	COG0742	ribosomal rna small subunit methyltransferase
L2O48_06185	COG0552	protein localization to endoplasmic reticulum
L2O48_06190	COG2884	Cell division ATP-binding protein ftsE
L2O48_06195	COG2177	Part of the ABC transporter FtsEX involved in
L2O48_06200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L2O48_06210	COG0705	Rhomboid family
L2O48_06215	COG1580	Controls the rotational direction of flagella during chemotaxis
L2O48_06220	COG3161	chorismate lyase activity
L2O48_06230	COG2937	Belongs to the GPAT DAPAT family
L2O48_06235	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L2O48_06245	COG0534	Mate efflux family protein
L2O48_06250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2O48_06270	COG3250	beta-galactosidase activity
L2O48_06305	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L2O48_06345	COG3550	peptidyl-serine autophosphorylation
L2O48_06390	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2O48_06460	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L2O48_06465	COG3300	MHYT domain
L2O48_06465	COG5001	Diguanylate cyclase
L2O48_06475	COG3852	Histidine kinase
L2O48_06485	COG0174	glutamine synthetase
L2O48_06490	COG1217	gtp-binding protein TYPA
L2O48_06495	COG1295	ribonuclease BN
L2O48_06500	COG1490	D-aminoacyl-tRNA deacylase activity
L2O48_06505	COG0456	acetyltransferase
L2O48_06515	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
L2O48_06520	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L2O48_06525	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L2O48_06530	COG3031	protein transport across the cell outer membrane
L2O48_06540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L2O48_06545	COG1459	type II secretion system
L2O48_06550	COG2165	general secretion pathway protein
L2O48_06555	COG2165	general secretion pathway protein
L2O48_06560	COG2165	general secretion pathway protein
L2O48_06565	COG4795	General secretion pathway protein
L2O48_06570	COG3156	type II secretion system protein K
L2O48_06575	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
L2O48_06580	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
L2O48_06590	COG1218	3'(2'),5'-bisphosphate nucleotidase
L2O48_06595	COG0494	nUDIX hydrolase
L2O48_06600	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
L2O48_06600	COG0316	Belongs to the HesB IscA family
L2O48_06605	COG1040	competence protein
L2O48_06610	COG0596	Alpha beta hydrolase
L2O48_06620	COG2183	response to ionizing radiation
L2O48_06625	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2O48_06645	COG0583	DNA-binding transcription factor activity
L2O48_06680	COG2233	PERMEase
L2O48_06685	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L2O48_06690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2O48_06695	COG1758	RNA polymerase activity
L2O48_06700	COG0194	GDP metabolic process
L2O48_06705	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
L2O48_06710	COG0248	Ppx GppA phosphatase
L2O48_06720	COG3118	belongs to the thioredoxin family
L2O48_06735	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
L2O48_06780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2O48_06790	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L2O48_06795	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
L2O48_06795	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
L2O48_06800	COG1072	(Pantothenic acid kinase))
L2O48_06825	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L2O48_06830	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L2O48_06835	COG0250	Participates in transcription elongation, termination and antitermination
L2O48_06850	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
L2O48_06855	COG0222	ribosome binding
L2O48_06860	COG0085	RNA polymerase activity
L2O48_06865	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
L2O48_06870	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
L2O48_06875	COG2816	NAD+ diphosphatase activity
L2O48_06880	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L2O48_06895	COG4942	peptidase
L2O48_06900	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L2O48_06915	COG0490	domain, Protein
L2O48_06915	COG0471	metal ion transport
L2O48_06925	COG1162	GTPase activity
L2O48_06930	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L2O48_06980	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L2O48_06985	COG0802	atpase or kinase
L2O48_06995	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L2O48_07000	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
L2O48_07010	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L2O48_07015	COG0330	HflC and HflK could
L2O48_07020	COG0330	HflC and HflK could
L2O48_07025	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
L2O48_07040	COG0545	Peptidyl-prolyl cis-trans isomerase
L2O48_07045	COG2964	Protein conserved in bacteria
L2O48_07050	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L2O48_07055	COG2923	Belongs to the DsrF TusC family
L2O48_07070	COG0049	tRNA binding
L2O48_07075	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L2O48_07080	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L2O48_07085	COG0360	Binds together with S18 to 16S ribosomal RNA
L2O48_07090	COG2965	DNA replication, synthesis of RNA primer
L2O48_07100	COG0359	binds to the 23S rRNA
L2O48_07115	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L2O48_07120	COG0166	Belongs to the GPI family
L2O48_07130	COG0735	belongs to the Fur family
L2O48_07180	COG2433	Pfam Transposase IS66
L2O48_07200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2O48_07220	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L2O48_07230	COG0175	sulfate reduction
L2O48_07300	COG0646	methionine synthase
L2O48_07300	COG1410	methionine synthase
L2O48_07305	COG0527	aspartate kinase activity
L2O48_07310	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L2O48_07320	COG2239	Acts as a magnesium transporter
L2O48_07330	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L2O48_07345	COG0629	single-stranded DNA binding
L2O48_07350	COG2200	EAL domain
L2O48_07350	COG2199	diguanylate cyclase activity
L2O48_07375	COG3409	Peptidoglycan-binding domain 1 protein
L2O48_07375	COG3267	Type II secretory pathway component ExeA
L2O48_07385	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L2O48_07390	COG1459	type II secretion system
L2O48_07400	COG2165	general secretion pathway protein
L2O48_07435	COG1077	Cell shape determining protein MreB Mrl
L2O48_07440	COG1792	Involved in formation and maintenance of cell shape
L2O48_07445	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
L2O48_07450	COG0424	maF-like protein
L2O48_07460	COG3164	Protein of unknown function
L2O48_07465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2O48_07470	COG0312	modulator of DNA gyrase
L2O48_07475	COG2235	arginine
L2O48_07495	COG0589	response to stress
L2O48_07505	COG2358	TRAP transporter, solute receptor (TAXI family
L2O48_07510	COG1438	arginine binding
L2O48_07520	COG0531	amino acid
L2O48_07525	COG0142	geranyltranstransferase activity
L2O48_07530	COG0261	This protein binds to 23S rRNA in the presence of protein L20
L2O48_07535	COG0211	Belongs to the bacterial ribosomal protein bL27 family
L2O48_07540	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L2O48_07545	COG2966	Psort location CytoplasmicMembrane, score
L2O48_07550	COG3610	response to peptide
L2O48_07565	COG2967	ApaG domain
L2O48_07570	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L2O48_07575	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
L2O48_07580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2O48_07585	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
L2O48_07590	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
L2O48_07640	COG0741	lytic transglycosylase activity
L2O48_07645	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
L2O48_07660	COG2066	Belongs to the glutaminase family
L2O48_07665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2O48_07670	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
L2O48_07680	COG1872	DUF167
L2O48_07685	COG0762	integral membrane protein
L2O48_07690	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L2O48_07695	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
L2O48_07710	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L2O48_07715	COG1678	Uncharacterized ACR, COG1678
L2O48_07725	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2O48_07730	COG2356	endonuclease I
L2O48_07735	COG3091	SprT-like family
L2O48_07740	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L2O48_07745	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L2O48_07750	COG0583	DNA-binding transcription factor activity
L2O48_07755	COG4771	TonB-dependent receptor
L2O48_07760	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L2O48_07765	COG0126	phosphoglycerate kinase activity
L2O48_07770	COG0191	fructose-bisphosphate aldolase activity
L2O48_07775	COG0668	transmembrane transport
L2O48_07795	COG3706	GGDEF domain
L2O48_07805	COG1349	DNA-binding transcription factor activity
L2O48_07815	COG4932	domain protein
L2O48_07815	COG5492	domain, Protein
L2O48_07835	COG3501	Rhs element vgr protein
L2O48_07840	COG4104	PAAR repeat-containing protein
L2O48_07975	COG1484	DNA-dependent DNA replication
L2O48_07980	COG4584	PFAM Integrase catalytic
L2O48_08110	COG0210	DNA helicase
L2O48_08130	COG3550	peptidyl-serine autophosphorylation
L2O48_08150	COG0358	DNA primase activity
L2O48_08155	COG1610	YqeY-like protein
L2O48_08160	COG0828	Belongs to the bacterial ribosomal protein bS21 family
L2O48_08165	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
L2O48_08180	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
L2O48_08185	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L2O48_08190	COG1968	undecaprenyl-diphosphatase activity
L2O48_08195	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L2O48_08200	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
L2O48_08205	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
L2O48_08210	COG0585	pseudouridine synthase activity
L2O48_08215	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L2O48_08220	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L2O48_08225	COG4942	peptidase
L2O48_08225	COG1388	LysM domain
L2O48_08230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L2O48_08235	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
L2O48_08245	COG4150	thiosulfate binding
L2O48_08255	COG4208	sulfate ABC transporter
L2O48_08260	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L2O48_08265	COG1546	Belongs to the CinA family
L2O48_08270	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
L2O48_08275	COG2137	regulation of response to DNA damage stimulus
L2O48_08280	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L2O48_08285	COG0527	aspartate kinase activity
L2O48_08290	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
L2O48_08330	COG3630	sodium ion export across plasma membrane
L2O48_08335	COG0511	ligase activity, forming carbon-carbon bonds
L2O48_08335	COG5016	pyruvate
L2O48_08340	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
L2O48_08350	COG1238	metal cluster binding
L2O48_08355	COG0612	Peptidase, M16
L2O48_08365	COG1854	S-ribosylhomocysteine lyase activity
L2O48_08370	COG4536	flavin adenine dinucleotide binding
L2O48_08375	COG4137	Cytochrome C assembly protein
L2O48_08380	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L2O48_08385	COG0228	four-way junction DNA binding
L2O48_08390	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L2O48_08395	COG0336	Belongs to the RNA methyltransferase TrmD family
L2O48_08400	COG0335	large ribosomal subunit rRNA binding
L2O48_08410	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
L2O48_08415	COG0237	dephospho-CoA kinase activity
L2O48_08425	COG1459	type II secretion system
L2O48_08430	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L2O48_08440	COG0157	Belongs to the NadC ModD family
L2O48_08450	COG0716	FMN binding
L2O48_08455	COG4974	Belongs to the 'phage' integrase family
L2O48_08460	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2O48_08465	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L2O48_08470	COG2186	Transcriptional regulator
L2O48_08475	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
L2O48_08480	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2O48_08485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2O48_08500	COG0288	reversible hydration of carbon dioxide
L2O48_08505	COG0659	secondary active sulfate transmembrane transporter activity
L2O48_08510	COG1131	(ABC) transporter
L2O48_08515	COG0842	Transport permease protein
L2O48_08525	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
L2O48_08535	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L2O48_08545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2O48_08550	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L2O48_08555	COG1489	DNA binding
L2O48_08560	COG1643	Atp-dependent helicase
L2O48_08565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2O48_08570	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2O48_08575	COG1049	propionate catabolic process, 2-methylcitrate cycle
L2O48_08580	COG1929	Belongs to the glycerate kinase type-1 family
L2O48_08585	COG2610	gluconate transmembrane transporter activity
L2O48_08590	COG3835	regulator
L2O48_08595	COG3112	Uncharacterised protein family (UPF0231)
L2O48_08605	COG0004	ammonium transporteR
L2O48_08610	COG1840	ABC-type Fe3 transport system, periplasmic component
L2O48_08625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2O48_08640	COG2971	BadF BadG BcrA BcrD
L2O48_08650	COG4608	Belongs to the ABC transporter superfamily
L2O48_08655	COG0444	Belongs to the ABC transporter superfamily
L2O48_08660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2O48_08675	COG0784	Response regulator, receiver
L2O48_08675	COG2205	protein histidine kinase activity
L2O48_08685	COG0628	permease
L2O48_08690	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
L2O48_08695	COG0316	Belongs to the HesB IscA family
L2O48_08710	COG0739	heme binding
L2O48_08715	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L2O48_08720	COG2239	Acts as a magnesium transporter
L2O48_08725	COG2027	D-alanyl-D-alanine carboxypeptidase
L2O48_08735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2O48_08740	COG1534	Rna-binding protein
L2O48_08745	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
L2O48_08750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2O48_08755	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L2O48_08760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2O48_08765	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L2O48_08780	COG0779	Required for maturation of 30S ribosomal subunits
L2O48_08785	COG0195	Participates in both transcription termination and antitermination
L2O48_08790	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
L2O48_08800	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L2O48_08805	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
L2O48_08820	COG1846	Transcriptional regulator
L2O48_08830	COG0826	peptidase U32
L2O48_08835	COG0826	peptidase U32
L2O48_08845	COG3154	lipid carrier protein
L2O48_08850	COG3153	acetyltransferase
L2O48_08875	COG0513	Belongs to the DEAD box helicase family
L2O48_08880	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
L2O48_08895	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
L2O48_08900	COG2204	response regulator
L2O48_08910	COG0667	Aldo Keto reductase
L2O48_08920	COG0494	nUDIX hydrolase
L2O48_08930	COG0730	response to heat
L2O48_08965	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
L2O48_08970	COG2194	sulfuric ester hydrolase activity
L2O48_08980	COG2433	Pfam Transposase IS66
L2O48_09000	COG3422	double-strand break repair
L2O48_09015	COG3550	peptidyl-serine autophosphorylation
L2O48_09050	COG2433	Pfam Transposase IS66
L2O48_09080	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
L2O48_09090	COG1283	sodium-dependent phosphate transmembrane transporter activity
L2O48_09095	COG0583	DNA-binding transcription factor activity
L2O48_09100	COG0640	Transcriptional regulator
L2O48_09105	COG0268	Binds directly to 16S ribosomal RNA
L2O48_09110	COG0728	peptidoglycan biosynthetic process
L2O48_09115	COG0196	riboflavin kinase activity
L2O48_09125	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
L2O48_09130	COG1047	Peptidyl-prolyl cis-trans
L2O48_09135	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
L2O48_09140	COG1966	Carbon starvation protein
L2O48_09155	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
L2O48_09160	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L2O48_09170	COG3279	Response regulator of the LytR AlgR family
L2O48_09175	COG3275	phosphorelay sensor kinase activity
L2O48_09180	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L2O48_09185	COG0287	Prephenate dehydrogenase
L2O48_09185	COG1605	Chorismate mutase
L2O48_09195	COG0488	(ABC) transporter
L2O48_09205	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
L2O48_09210	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
L2O48_09215	COG5001	Diguanylate cyclase
L2O48_09220	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
L2O48_09225	COG1605	Chorismate mutase
L2O48_09225	COG0077	Prephenate dehydratase
L2O48_09230	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
L2O48_09240	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2O48_09245	COG0564	pseudouridine synthase activity
L2O48_09250	COG1496	oxidoreductase activity
L2O48_09255	COG0542	response to heat
L2O48_09295	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2O48_09300	COG0826	peptidase U32
L2O48_09310	COG0745	RESPONSE REGULATOR receiver
L2O48_09315	COG5002	protein histidine kinase activity
L2O48_09325	COG0248	Ppx GppA phosphatase
L2O48_09330	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
L2O48_09340	COG0581	inorganic phosphate transmembrane transporter activity
L2O48_09345	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L2O48_09350	COG0704	Plays a role in the regulation of phosphate uptake
L2O48_09360	COG0450	alkyl hydroperoxide reductase
L2O48_09365	COG0583	DNA-binding transcription factor activity
L2O48_09370	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L2O48_09380	COG0517	IMP dehydrogenase activity
L2O48_09390	COG0343	queuine tRNA-ribosyltransferase activity
L2O48_09395	COG1862	Preprotein translocase
L2O48_09400	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2O48_09405	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2O48_09410	COG0483	inositol monophosphate 1-phosphatase activity
L2O48_09415	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
L2O48_09420	COG1959	2 iron, 2 sulfur cluster binding
L2O48_09430	COG0822	iron-sulfur transferase activity
L2O48_09435	COG0316	Belongs to the HesB IscA family
L2O48_09445	COG0443	Heat shock 70 kDa protein
L2O48_09450	COG0633	Ferredoxin
L2O48_09455	COG2975	iron-sulfur cluster assembly
L2O48_09460	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L2O48_09475	COG1426	Protein conserved in bacteria
L2O48_09480	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
L2O48_09485	COG0124	histidyl-tRNA synthetase
L2O48_09490	COG2976	Protein conserved in bacteria
L2O48_09495	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2O48_09500	COG1160	GTP binding
L2O48_09515	COG0516	GMP reductase activity
L2O48_09515	COG0517	IMP dehydrogenase activity
L2O48_09520	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2O48_09520	COG0519	Catalyzes the synthesis of GMP from XMP
L2O48_09525	COG0351	phosphomethylpyrimidine kinase
L2O48_09535	COG1584	GPR1 FUN34 yaaH family protein
L2O48_09540	COG1115	amino acid carrier protein
L2O48_09570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2O48_09570	COG3711	transcriptional antiterminator
L2O48_09585	COG3964	amidohydrolase
L2O48_09725	COG2003	Belongs to the UPF0758 family
L2O48_09740	COG1715	Restriction endonuclease
L2O48_09745	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
L2O48_09765	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
L2O48_09770	COG0582	viral genome integration into host DNA
L2O48_09785	COG2867	negative regulation of translational initiation
L2O48_09790	COG2914	Belongs to the UPF0125 (RnfH) family
L2O48_09795	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2O48_09800	COG0497	DNA recombination
L2O48_09805	COG3033	Beta-eliminating lyase
L2O48_09810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L2O48_09815	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
L2O48_09820	COG0443	Heat shock 70 kDa protein
L2O48_09825	COG0484	heat shock protein binding
L2O48_09855	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
L2O48_09860	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
L2O48_09870	COG0583	DNA-binding transcription factor activity
L2O48_09875	COG0590	tRNA wobble adenosine to inosine editing
L2O48_09880	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
L2O48_09885	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L2O48_09885	COG0047	phosphoribosylformylglycinamidine synthase activity
L2O48_09905	COG2979	Protein of unknown function (DUF533)
L2O48_09910	COG0442	prolyl-tRNA aminoacylation
L2O48_09915	COG1720	tRNA m6t6A37 methyltransferase activity
L2O48_09920	COG0254	rRNA binding
L2O48_09925	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L2O48_09955	COG3098	single-species biofilm formation
L2O48_09960	COG0564	pseudouridine synthase activity
L2O48_09965	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
L2O48_09970	COG0142	geranyltranstransferase activity
L2O48_09975	COG1722	exodeoxyribonuclease VII activity
L2O48_09980	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L2O48_09990	COG0301	tRNA thio-modification
L2O48_09990	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L2O48_09995	COG0583	DNA-binding transcription factor activity
L2O48_10000	COG2363	Small membrane protein
L2O48_10005	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
L2O48_10010	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L2O48_10015	COG1611	Belongs to the LOG family
L2O48_10040	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
L2O48_10045	COG1464	Belongs to the NlpA lipoprotein family
L2O48_10050	COG2011	ABC-type metal ion transport system permease component
L2O48_10055	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2O48_10060	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
L2O48_10075	COG1263	PTS System
L2O48_10075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L2O48_10080	COG0366	Alpha amylase catalytic
L2O48_10085	COG0745	RESPONSE REGULATOR receiver
L2O48_10090	COG2205	protein histidine kinase activity
L2O48_10125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2O48_10130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2O48_10135	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2O48_10140	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L2O48_10145	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L2O48_10185	COG1045	serine acetyltransferase
L2O48_10195	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
L2O48_10220	COG0489	protein tyrosine kinase activity
L2O48_10225	COG1596	polysaccharide export
L2O48_10255	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2O48_10260	COG0321	lipoyl(octanoyl) transferase activity
L2O48_10265	COG2921	Belongs to the UPF0250 family
L2O48_10270	COG1686	Belongs to the peptidase S11 family
L2O48_10275	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L2O48_10280	COG0772	Belongs to the SEDS family
L2O48_10285	COG0768	penicillin binding
L2O48_10290	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
L2O48_10295	COG0799	negative regulation of ribosome biogenesis
L2O48_10300	COG1466	dna polymerase III delta subunit
L2O48_10305	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
L2O48_10310	COG0495	leucyl-tRNA aminoacylation
L2O48_10315	COG2888	peptidyl-tyrosine sulfation
L2O48_10320	COG0815	Transfers the fatty acyl group on membrane lipoproteins
L2O48_10325	COG4535	Mg2 and Co2 transporter CorC
L2O48_10330	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
L2O48_10335	COG1702	phosphate starvation-inducible protein PhoH
L2O48_10340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L2O48_10345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2O48_10350	COG2190	(PTS) system
L2O48_10355	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2O48_10360	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2O48_10365	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L2O48_10370	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
L2O48_10375	COG3115	cell septum assembly
L2O48_10380	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L2O48_10400	COG0789	Transcriptional regulator
L2O48_10410	COG0330	HflC and HflK could
L2O48_10415	COG3118	belongs to the thioredoxin family
L2O48_10420	COG1090	epimerase
L2O48_10425	COG0622	Phosphoesterase
L2O48_10440	COG3710	Transcriptional regulator
L2O48_10445	COG0326	Molecular chaperone. Has ATPase activity
L2O48_10455	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
L2O48_10460	COG3104	oligopeptide transport
L2O48_10470	COG0367	asparagine synthase
L2O48_10475	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2O48_10475	COG4651	solute:proton antiporter activity
L2O48_10480	COG1940	carbohydrate kinase activity
L2O48_10480	COG1846	Transcriptional regulator
L2O48_10485	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
L2O48_10490	COG1263	PTS System
L2O48_10490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L2O48_10490	COG2190	(PTS) system
L2O48_10495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2O48_10505	COG0101	tRNA pseudouridine synthase activity
L2O48_10510	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
L2O48_10515	COG0285	dihydrofolate synthase activity
L2O48_10520	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
L2O48_10525	COG1286	toxin biosynthetic process
L2O48_10530	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
L2O48_10535	COG2056	Na+-H+ antiporter family
L2O48_10540	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2O48_10550	COG0346	lactoylglutathione lyase activity
L2O48_10555	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L2O48_10560	COG4660	Part of a membrane complex involved in electron transport
L2O48_10565	COG4659	FMN binding
L2O48_10570	COG4658	electron transport chain
L2O48_10575	COG4656	Part of a membrane complex involved in electron transport
L2O48_10580	COG2878	Part of a membrane complex involved in electron transport
L2O48_10585	COG4657	Part of a membrane complex involved in electron transport
L2O48_10595	COG4774	siderophore transport
L2O48_10595	COG1629	transport
L2O48_10600	COG2382	esterase
L2O48_10630	COG1535	isochorismatase
L2O48_10630	COG3433	isochorismatase activity
L2O48_10635	COG1021	2,3-dihydroxybenzoate-AMP ligase
L2O48_10640	COG1169	isochorismate synthase
L2O48_10645	COG1028	Short-chain dehydrogenase reductase Sdr
L2O48_10650	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L2O48_10665	COG0556	nucleotide-excision repair
L2O48_10670	COG2204	response regulator
L2O48_10675	COG2198	Histidine kinase
L2O48_10680	COG0391	Required for morphogenesis under gluconeogenic growth conditions
L2O48_10685	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L2O48_10690	COG0521	Mo-molybdopterin cofactor biosynthetic process
L2O48_10700	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
L2O48_10705	COG0314	molybdopterin synthase activity
L2O48_10710	COG2199	diguanylate cyclase activity
L2O48_10715	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
L2O48_10715	COG0617	tRNA 3'-terminal CCA addition
L2O48_10715	COG0517	IMP dehydrogenase activity
L2O48_10725	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
L2O48_10735	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2O48_10735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2O48_10740	COG0489	protein tyrosine kinase activity
L2O48_10745	COG0572	uridine kinase
L2O48_10750	COG2982	Protein involved in outer membrane biogenesis
L2O48_10755	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
L2O48_10760	COG2067	long-chain fatty acid transport protein
L2O48_10765	COG2067	long-chain fatty acid transport protein
L2O48_10775	COG1595	DNA-templated transcription, initiation
L2O48_10780	COG0183	Belongs to the thiolase family
L2O48_10785	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2O48_10785	COG1024	Enoyl-CoA hydratase
L2O48_10790	COG0778	Nitroreductase
L2O48_10795	COG0583	DNA-binding transcription factor activity
L2O48_10800	COG0745	RESPONSE REGULATOR receiver
L2O48_10805	COG2832	Protein of unknown function (DUF454)
L2O48_10810	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L2O48_10825	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L2O48_10835	COG2983	Belongs to the UPF0260 family
L2O48_10850	COG2226	methyltransferase
L2O48_10865	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L2O48_10875	COG3139	Protein of unknown function (DUF1315)
L2O48_10880	COG0252	asparaginase activity
L2O48_10885	COG0616	signal peptide processing
L2O48_10890	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2O48_10890	COG1902	pentaerythritol trinitrate reductase activity
L2O48_10895	COG0788	formyltetrahydrofolate deformylase activity
L2O48_10905	COG1199	ATP-dependent helicase activity
L2O48_10910	COG1214	PFAM Peptidase M22, glycoprotease
L2O48_10925	COG0596	Alpha beta hydrolase
L2O48_10930	COG0318	PFAM AMP-dependent synthetase and ligase
L2O48_10935	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
L2O48_10940	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
L2O48_10945	COG2894	cell division
L2O48_10955	COG3100	YcgL domain-containing protein
L2O48_10960	COG2951	lytic endotransglycosylase activity
L2O48_10965	COG0583	DNA-binding transcription factor activity
L2O48_10970	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L2O48_10995	COG2433	Pfam Transposase IS66
L2O48_11040	COG2433	Pfam Transposase IS66
L2O48_11045	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2O48_11090	COG3550	peptidyl-serine autophosphorylation
L2O48_11130	COG4628	conserved protein (DUF2132)
L2O48_11145	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2O48_11155	COG0513	Belongs to the DEAD box helicase family
L2O48_11165	COG1760	l-serine dehydratase
L2O48_11170	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L2O48_11180	COG2205	protein histidine kinase activity
L2O48_11185	COG1653	transport
L2O48_11190	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L2O48_11195	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
L2O48_11200	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
L2O48_11215	COG0544	peptidyl-prolyl cis-trans isomerase activity
L2O48_11225	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
L2O48_11230	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
L2O48_11235	COG0776	regulation of translation
L2O48_11240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2O48_11245	COG1555	photosystem II stabilization
L2O48_11250	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
L2O48_11255	COG0539	negative regulation of cytoplasmic translation
L2O48_11260	COG0776	regulation of translation
L2O48_11265	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
L2O48_11270	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
L2O48_11285	COG0583	DNA-binding transcription factor activity
L2O48_11295	COG0686	Belongs to the AlaDH PNT family
L2O48_11300	COG1522	sequence-specific DNA binding
L2O48_11305	COG1674	ftsk spoiiie
L2O48_11315	COG0501	Belongs to the peptidase M48B family
L2O48_11325	COG0300	oxidoreductase activity
L2O48_11340	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L2O48_11350	COG2268	Band 7 protein
L2O48_11360	COG1032	radical SAM domain protein
L2O48_11370	COG2199	diguanylate cyclase activity
L2O48_11370	COG2200	EAL domain
L2O48_11370	COG2203	Gaf domain
L2O48_11385	COG0583	DNA-binding transcription factor activity
L2O48_11390	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
L2O48_11400	COG2350	Protein conserved in bacteria
L2O48_11425	COG0159	tryptophan synthase activity
L2O48_11430	COG0133	tryptophan synthase activity
L2O48_11435	COG0135	phosphoribosylanthranilate isomerase activity
L2O48_11435	COG0134	indole-3-glycerol-phosphate synthase activity
L2O48_11440	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L2O48_11445	COG0512	Glutamine amidotransferase of anthranilate synthase
L2O48_11450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L2O48_11460	COG0613	PHP domain protein
L2O48_11465	COG0009	L-threonylcarbamoyladenylate synthase
L2O48_11470	COG1187	pseudouridine synthase activity
L2O48_11485	COG1595	DNA-templated transcription, initiation
L2O48_11500	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
L2O48_11505	COG4988	ABC transporter
L2O48_11510	COG0492	ferredoxin-NADP+ reductase activity
L2O48_11530	COG2949	membrane
L2O48_11540	COG0281	malic enzyme
L2O48_11550	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
L2O48_11555	COG3273	potassium ion transport
L2O48_11555	COG2985	domain, Protein
L2O48_11560	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L2O48_11570	COG1737	Transcriptional regulator
L2O48_11575	COG0076	glutamate decarboxylase activity
L2O48_11585	COG2431	L-lysine efflux transmembrane transporter activity
L2O48_11595	COG3070	regulator of competence-specific genes
L2O48_11610	COG4191	Histidine kinase
L2O48_11610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2O48_11620	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
L2O48_11625	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L2O48_11630	COG2915	High frequency lysogenization protein hflD homolog
L2O48_11635	COG0482	sulfurtransferase activity
L2O48_11645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2O48_11650	COG2916	Histone family protein nucleoid-structuring protein H-NS
L2O48_11655	COG1757	Na H antiporter
L2O48_11660	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L2O48_11665	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L2O48_11670	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L2O48_11675	COG0131	Imidazoleglycerol-phosphate dehydratase
L2O48_11675	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
L2O48_11680	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L2O48_11685	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
L2O48_11690	COG0107	imidazoleglycerol-phosphate synthase activity
L2O48_11695	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L2O48_11695	COG0140	phosphoribosyl-ATP diphosphatase activity
L2O48_11700	COG1187	pseudouridine synthase activity
L2O48_11710	COG1278	Cold shock
L2O48_11715	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L2O48_11720	COG0542	response to heat
L2O48_11725	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
L2O48_11730	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
L2O48_11735	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L2O48_11750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L2O48_11755	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
L2O48_11760	COG0297	glycogen (starch) synthase activity
L2O48_11780	COG3070	regulator of competence-specific genes
L2O48_11785	COG1609	Transcriptional regulator
L2O48_11795	COG0745	RESPONSE REGULATOR receiver
L2O48_11800	COG1434	Gram-negative-bacterium-type cell wall biogenesis
L2O48_11805	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2O48_11815	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
L2O48_11820	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
L2O48_11835	COG4067	protein conserved in archaea
L2O48_11835	COG0189	ligase activity
L2O48_11840	COG0500	methyltransferase
L2O48_11845	COG4106	trans-aconitate 2-methyltransferase activity
L2O48_11865	COG1801	Protein of unknown function DUF72
L2O48_11870	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
L2O48_11875	COG1435	thymidine kinase activity
L2O48_11880	COG1434	Gram-negative-bacterium-type cell wall biogenesis
L2O48_11905	COG2116	formate transmembrane transporter activity
L2O48_11910	COG4459	periplasmic nitrate reductase
L2O48_11915	COG3005	denitrification pathway
L2O48_11920	COG0243	molybdopterin cofactor binding
L2O48_11930	COG1227	inorganic diphosphatase activity
L2O48_11945	COG4172	Belongs to the ABC transporter superfamily
L2O48_11955	COG4171	peptide transport system, permease
L2O48_11970	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
L2O48_11975	COG1842	Phage shock protein A
L2O48_11990	COG0519	Catalyzes the synthesis of GMP from XMP
L2O48_11995	COG0626	cystathionine gamma-synthase activity
L2O48_12005	COG0733	neurotransmitter:sodium symporter activity
L2O48_12010	COG0564	pseudouridine synthase activity
L2O48_12020	COG2200	EAL domain
L2O48_12030	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L2O48_12035	COG4136	ATPase activity
L2O48_12040	COG4135	transport system, permease component
L2O48_12045	COG4134	Bacterial extracellular solute-binding protein
L2O48_12055	COG3313	Fe-S protein
L2O48_12085	COG0513	Belongs to the DEAD box helicase family
L2O48_12100	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
L2O48_12105	COG2205	protein histidine kinase activity
L2O48_12120	COG1061	Type III restriction enzyme res subunit
L2O48_12125	COG1187	pseudouridine synthase activity
L2O48_12130	COG2814	Major facilitator Superfamily
L2O48_12140	COG0702	epimerase
L2O48_12145	COG0534	Mate efflux family protein
L2O48_12150	COG4181	ATPase activity
L2O48_12165	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L2O48_12185	COG0840	transmembrane signaling receptor activity
L2O48_12215	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L2O48_12220	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L2O48_12225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2O48_12235	COG0840	transmembrane signaling receptor activity
L2O48_12280	COG0511	ligase activity, forming carbon-carbon bonds
L2O48_12280	COG5016	pyruvate
L2O48_12285	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
L2O48_12295	COG4565	transcriptional regulatory protein
L2O48_12305	COG2301	Belongs to the HpcH HpaI aldolase family
L2O48_12310	COG3051	citrate lyase alpha subunit
L2O48_12320	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
L2O48_12345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2O48_12345	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2O48_12345	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2O48_12350	COG2207	Transcriptional regulator
L2O48_12360	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2O48_12370	COG1342	Belongs to the UPF0251 family
L2O48_12390	COG1129	ABC transporter
L2O48_12405	COG1902	pentaerythritol trinitrate reductase activity
L2O48_12410	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
L2O48_12415	COG5002	protein histidine kinase activity
L2O48_12420	COG0745	RESPONSE REGULATOR receiver
L2O48_12450	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
L2O48_12455	COG0372	Belongs to the citrate synthase family
L2O48_12460	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L2O48_12465	COG2828	Protein conserved in bacteria
L2O48_12485	COG0561	phosphatase activity
L2O48_12490	COG0602	queuosine metabolic process
L2O48_12535	COG1254	Belongs to the acylphosphatase family
L2O48_12540	COG2920	part of a sulfur-relay system
L2O48_12545	COG0670	Belongs to the BI1 family
L2O48_12550	COG1126	abc transporter atp-binding protein
L2O48_12555	COG0765	amino acid transport
L2O48_12560	COG4597	amino acid ABC transporter
L2O48_12565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2O48_12570	COG1648	precorrin-2 dehydrogenase activity
L2O48_12570	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L2O48_12585	COG1666	GTP binding
L2O48_12590	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L2O48_12610	COG2996	Protein conserved in bacteria
L2O48_12620	COG3008	intermembrane lipid transfer
L2O48_12625	COG2995	paraquat-inducible protein a
L2O48_12630	COG1132	(ABC) transporter
L2O48_12635	COG1956	GAF domain-containing protein
L2O48_12640	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
L2O48_12655	COG0308	aminopeptidase N
L2O48_12665	COG2902	Dehydrogenase
L2O48_12670	COG0167	dihydroorotate dehydrogenase activity
L2O48_12700	COG0488	(ABC) transporter
L2O48_12715	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L2O48_12720	COG1067	ATP-dependent peptidase activity
L2O48_12725	COG3120	sequence-specific DNA binding
L2O48_12820	COG3278	Belongs to the heme-copper respiratory oxidase family
L2O48_12835	COG2010	Cytochrome c
L2O48_12845	COG2217	Heavy metal translocating P-type atpase
L2O48_12860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2O48_12865	COG0589	response to stress
L2O48_12890	COG3842	ATPase activity
L2O48_12895	COG1176	ABC-type spermidine putrescine transport system, permease component I
L2O48_12900	COG1177	transmembrane transport
L2O48_12905	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
L2O48_12915	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L2O48_12920	COG0004	ammonium transporteR
L2O48_12925	COG0488	(ABC) transporter
L2O48_12930	COG2197	response regulator
L2O48_12940	COG2271	Major facilitator Superfamily
L2O48_12945	COG1840	ABC-type Fe3 transport system, periplasmic component
L2O48_12955	COG3842	ATPase activity
L2O48_12960	COG0746	molybdenum cofactor guanylyltransferase activity
L2O48_12975	COG1940	carbohydrate kinase activity
L2O48_12980	COG3148	PFAM DTW domain containing protein
L2O48_12990	COG0840	transmembrane signaling receptor activity
L2O48_12995	COG0791	NLP P60 protein
L2O48_13005	COG3001	Fructosamine kinase
L2O48_13020	COG1793	dna ligase
L2O48_13025	COG4667	esterase of the alpha-beta hydrolase superfamily
L2O48_13040	COG0848	biopolymer transport protein
L2O48_13045	COG0811	peptide transport
L2O48_13050	COG0811	peptide transport
L2O48_13080	COG0625	glutathione transferase activity
L2O48_13090	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
L2O48_13100	COG2195	Cleaves the N-terminal amino acid of tripeptides
L2O48_13115	COG1115	amino acid carrier protein
L2O48_13120	COG1280	lysine exporter protein (LysE YggA)
L2O48_13125	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
L2O48_13135	COG2433	Pfam Transposase IS66
L2O48_13155	COG1204	response to ionizing radiation
L2O48_13170	COG2433	Pfam Transposase IS66
L2O48_13200	COG0673	inositol 2-dehydrogenase activity
L2O48_13220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2O48_13225	COG3962	Belongs to the TPP enzyme family
L2O48_13230	COG3718	enzyme involved in inositol metabolism
L2O48_13245	COG0517	IMP dehydrogenase activity
L2O48_13245	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L2O48_13250	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2O48_13255	COG0673	inositol 2-dehydrogenase activity
L2O48_13270	COG0477	Major facilitator Superfamily
L2O48_13275	COG0583	DNA-binding transcription factor activity
L2O48_13285	COG1643	Atp-dependent helicase
L2O48_13350	COG1609	Transcriptional regulator
L2O48_13355	COG2723	6-phospho-beta-galactosidase activity
L2O48_13360	COG0513	Belongs to the DEAD box helicase family
L2O48_13365	COG0243	molybdopterin cofactor binding
L2O48_13370	COG3005	denitrification pathway
L2O48_13375	COG1278	Cold shock
L2O48_13390	COG4191	Histidine kinase
L2O48_13390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2O48_13395	COG0471	metal ion transport
L2O48_13405	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L2O48_13425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L2O48_13435	COG3768	UPF0283 membrane protein
L2O48_13440	COG3106	COG3106 Predicted ATPase
L2O48_13455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L2O48_13460	COG0494	nUDIX hydrolase
L2O48_13465	COG0814	amino acid
L2O48_13470	COG1760	l-serine dehydratase
L2O48_13480	COG2356	endonuclease I
L2O48_13485	COG0720	synthase
L2O48_13490	COG0840	transmembrane signaling receptor activity
L2O48_13495	COG0017	Asparaginyl-tRNA synthetase
L2O48_13505	COG2201	protein-glutamate methylesterase activity
L2O48_13510	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
L2O48_13515	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L2O48_13520	COG0835	chemotaxis
L2O48_13530	COG2198	Histidine kinase
L2O48_13530	COG0643	Histidine kinase
L2O48_13540	COG0745	RESPONSE REGULATOR receiver
L2O48_13545	COG0840	transmembrane signaling receptor activity
L2O48_13550	COG2770	Histidine kinase
L2O48_13550	COG3437	response regulator, receiver
L2O48_13555	COG1448	Aminotransferase
L2O48_13560	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
L2O48_13575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2O48_13580	COG1846	Transcriptional regulator
L2O48_13595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2O48_13600	COG3108	Peptidase M15
L2O48_13605	COG2989	Protein conserved in bacteria
L2O48_13635	COG1940	carbohydrate kinase activity
L2O48_13640	COG4771	TonB-dependent receptor
L2O48_13640	COG1629	transport
L2O48_13645	COG0748	coenzyme F420 binding
L2O48_13650	COG3721	Heme iron utilization protein
L2O48_13655	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
L2O48_13660	COG0811	peptide transport
L2O48_13665	COG0848	biopolymer transport protein
L2O48_13675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2O48_13680	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
L2O48_13685	COG1054	Belongs to the UPF0176 family
L2O48_13695	COG0840	transmembrane signaling receptor activity
L2O48_13700	COG1621	beta-fructofuranosidase activity
L2O48_13710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L2O48_13710	COG1263	PTS System
L2O48_13715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2O48_13720	COG2200	EAL domain
L2O48_13725	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2O48_13730	COG0840	transmembrane signaling receptor activity
L2O48_13755	COG3220	belongs to the UPF0276 family
L2O48_13775	COG1294	oxidase, subunit
L2O48_13785	COG0251	oxidation-reduction process
L2O48_13805	COG2433	Pfam Transposase IS66
L2O48_13845	COG0515	serine threonine protein kinase
L2O48_13845	COG4991	sh3 domain protein
L2O48_13845	COG3064	Membrane
L2O48_13870	COG1716	ATPase activity
L2O48_13890	COG1181	Belongs to the D-alanine--D-alanine ligase family
L2O48_13970	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L2O48_14010	COG0784	Response regulator, receiver
L2O48_14010	COG0835	chemotaxis
L2O48_14020	COG4565	transcriptional regulatory protein
L2O48_14025	COG3290	protein histidine kinase activity
L2O48_14040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2O48_14065	COG3063	Type IV pilus biogenesis stability protein PilW
L2O48_14080	COG1451	nucleotide metabolic process
L2O48_14090	COG0583	DNA-binding transcription factor activity
L2O48_14110	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
L2O48_14115	COG4139	cobalamin transport
L2O48_14120	COG2988	succinylglutamate desuccinylase activity
L2O48_14135	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
L2O48_14140	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L2O48_14145	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
L2O48_14145	COG3064	Membrane
L2O48_14145	COG1073	alpha beta
L2O48_14150	COG2994	toxin metabolic process
L2O48_14180	COG0702	epimerase
L2O48_14185	COG1823	symporter activity
L2O48_14190	COG2925	Exonuclease
L2O48_14195	COG1380	Effector of murein hydrolase LrgA
L2O48_14200	COG1346	cytolysis
L2O48_14210	COG5001	Diguanylate cyclase
L2O48_14225	COG0500	methyltransferase
L2O48_14235	COG0776	regulation of translation
L2O48_14240	COG0072	phenylalanine-tRNA ligase activity
L2O48_14240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2O48_14245	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
L2O48_14285	COG0322	excinuclease ABC activity
L2O48_14290	COG2197	response regulator
L2O48_14295	COG0417	DNA replication proofreading
L2O48_14305	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
L2O48_14310	COG3099	Belongs to the UPF0263 family
L2O48_14315	COG3097	Belongs to the UPF0267 family
L2O48_14325	COG1228	amidohydrolase
L2O48_14330	COG0010	Belongs to the arginase family
L2O48_14340	COG2986	histidine ammonia-lyase
L2O48_14355	COG0247	lactate metabolic process
L2O48_14355	COG0277	FAD linked oxidase domain protein
L2O48_14385	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L2O48_14390	COG1960	acyl-CoA dehydrogenase activity
L2O48_14415	COG3300	MHYT domain
L2O48_14415	COG5001	Diguanylate cyclase
L2O48_14435	COG1401	restriction endodeoxyribonuclease activity
L2O48_14450	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L2O48_14470	COG3118	belongs to the thioredoxin family
L2O48_14475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L2O48_14480	COG0247	lactate metabolic process
L2O48_14485	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
L2O48_14490	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
L2O48_14495	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L2O48_14500	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L2O48_14520	COG3132	Protein of unknown function, DUF480
L2O48_14525	COG2827	Endonuclease containing a URI domain
L2O48_14540	COG0784	Response regulator, receiver
L2O48_14540	COG5002	protein histidine kinase activity
L2O48_14570	COG1289	transmembrane transporter activity
L2O48_14575	COG0210	DNA helicase
L2O48_14580	COG1803	Methylglyoxal synthase
L2O48_14585	COG1879	ABC-type sugar transport system periplasmic component
L2O48_14590	COG2205	protein histidine kinase activity
L2O48_14590	COG2198	Histidine kinase
L2O48_14590	COG0784	Response regulator, receiver
L2O48_14595	COG0469	pyruvate kinase activity
L2O48_14600	COG2271	Major facilitator Superfamily
L2O48_14620	COG1979	alcohol dehydrogenase
L2O48_14625	COG2207	Transcriptional regulator
L2O48_14635	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
L2O48_14650	COG3111	PFAM Bacterial OB fold (BOF) protein
L2O48_14655	COG1492	cobalamin metabolic process
L2O48_14660	COG0725	ABC transporter, periplasmic molybdate-binding protein
L2O48_14665	COG4149	molybdate abc transporter
L2O48_14670	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L2O48_14680	COG2203	Gaf domain
L2O48_14680	COG3706	GGDEF domain
L2O48_14680	COG5001	Diguanylate cyclase
L2O48_14680	COG4251	negative regulation of phosphorylation
L2O48_14695	COG3437	response regulator, receiver
L2O48_14705	COG3852	Histidine kinase
L2O48_14710	COG4191	Histidine kinase
L2O48_14715	COG5001	Diguanylate cyclase
L2O48_14715	COG3300	MHYT domain
L2O48_14760	COG3706	GGDEF domain
L2O48_14765	COG1328	CTP reductase activity
L2O48_14770	COG0602	queuosine metabolic process
L2O48_14780	COG0189	ligase activity
L2O48_14780	COG4067	protein conserved in archaea
L2O48_14790	COG4166	transmembrane transport
L2O48_14795	COG4174	ABC transporter (Permease)
L2O48_14800	COG4239	(ABC) transporter, permease
L2O48_14805	COG4172	Belongs to the ABC transporter superfamily
L2O48_14810	COG5001	Diguanylate cyclase
L2O48_14810	COG2203	Gaf domain
L2O48_14810	COG3706	GGDEF domain
L2O48_14810	COG4251	negative regulation of phosphorylation
L2O48_14820	COG3038	cytochrome b561
L2O48_14825	COG2353	YceI-like domain
L2O48_14830	COG0840	transmembrane signaling receptor activity
L2O48_14835	COG2433	Pfam Transposase IS66
L2O48_14880	COG2433	Pfam Transposase IS66
L2O48_14935	COG0582	viral genome integration into host DNA
L2O48_14950	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L2O48_14960	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
L2O48_14965	COG0513	Belongs to the DEAD box helicase family
L2O48_14995	COG2433	Pfam Transposase IS66
L2O48_15015	COG0500	methyltransferase
L2O48_15025	COG2433	Pfam Transposase IS66
L2O48_15155	COG2433	Pfam Transposase IS66
L2O48_15235	COG1357	PFAM Pentapeptide repeats (8 copies)
L2O48_15250	COG2433	Pfam Transposase IS66
L2O48_15280	COG2433	Pfam Transposase IS66
L2O48_15445	COG3040	lipid binding
L2O48_15505	COG2433	Pfam Transposase IS66
L2O48_15535	COG0724	RNA recognition motif
L2O48_15560	COG2433	Pfam Transposase IS66
L2O48_15600	COG0023	Translation Initiation Factor
L2O48_15615	COG1181	Belongs to the D-alanine--D-alanine ligase family
L2O48_15625	COG0045	succinate-CoA ligase (ADP-forming) activity
L2O48_15625	COG1042	CoA-binding domain protein
L2O48_15625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L2O48_15630	COG0583	DNA-binding transcription factor activity
L2O48_15645	COG2433	Pfam Transposase IS66
L2O48_15660	COG2433	Pfam Transposase IS66
L2O48_15675	COG3140	Belongs to the UPF0181 family
L2O48_15690	COG0745	RESPONSE REGULATOR receiver
L2O48_15700	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
L2O48_15705	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
L2O48_15720	COG3706	GGDEF domain
L2O48_15725	COG1278	Cold shock
L2O48_15735	COG0840	transmembrane signaling receptor activity
L2O48_15750	COG2501	S4 domain
L2O48_15755	COG0625	glutathione transferase activity
L2O48_15770	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L2O48_15775	COG0488	(ABC) transporter
L2O48_15790	COG2050	protein possibly involved in aromatic compounds catabolism
L2O48_15800	COG2824	Alkylphosphonate utilization operon protein PhnA
L2O48_15825	COG2433	Pfam Transposase IS66
L2O48_15835	COG0737	Belongs to the 5'-nucleotidase family
L2O48_15840	COG3593	DNA synthesis involved in DNA repair
L2O48_15850	COG0583	DNA-binding transcription factor activity
L2O48_15855	COG2116	formate transmembrane transporter activity
L2O48_15865	COG3104	oligopeptide transport
L2O48_15875	COG2188	Transcriptional regulator
L2O48_15880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2O48_15885	COG1011	Hydrolase
L2O48_15890	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
L2O48_15895	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L2O48_15900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2O48_15910	COG2759	Belongs to the formate--tetrahydrofolate ligase family
L2O48_15915	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L2O48_15915	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L2O48_15920	COG0302	gtp cyclohydrolase
L2O48_15925	COG0303	'Molybdopterin
L2O48_15930	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L2O48_15935	COG2897	thiosulfate sulfurtransferase activity
L2O48_15955	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L2O48_15970	COG0545	Peptidyl-prolyl cis-trans isomerase
L2O48_15975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2O48_15990	COG2433	Pfam Transposase IS66
L2O48_15995	COG2433	Pfam Transposase IS66
L2O48_16015	COG1742	UPF0060 membrane protein
L2O48_16050	COG2433	Pfam Transposase IS66
L2O48_16055	COG1484	DNA-dependent DNA replication
L2O48_16075	COG3069	C4-dicarboxylate transmembrane transporter activity
L2O48_16080	COG2197	response regulator
L2O48_16085	COG3850	Histidine kinase
L2O48_16090	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2O48_16100	COG0243	molybdopterin cofactor binding
L2O48_16110	COG3005	denitrification pathway
L2O48_16120	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2O48_16125	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2O48_16150	COG3833	ABC-type maltose transport systems, permease component
L2O48_16155	COG1175	transmembrane transport
L2O48_16160	COG2182	Extracellular solute-binding protein
L2O48_16190	COG3842	ATPase activity
L2O48_16205	COG3730	PTS system glucitol sorbitol-specific
L2O48_16210	COG1349	DNA-binding transcription factor activity
L2O48_16215	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2O48_16220	COG1028	Short-chain dehydrogenase reductase Sdr
L2O48_16235	COG3730	PTS system glucitol sorbitol-specific
L2O48_16255	COG3675	Pfam Lipase (class 3)
L2O48_16265	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
L2O48_16280	COG0577	efflux transmembrane transporter activity
L2O48_16280	COG1136	(ABC) transporter
L2O48_16290	COG1136	(ABC) transporter
L2O48_16295	COG0523	cobalamin synthesis protein
L2O48_16300	COG0038	chloride channel
L2O48_16310	COG0156	8-amino-7-oxononanoate synthase activity
L2O48_16315	COG2205	protein histidine kinase activity
L2O48_16315	COG0784	Response regulator, receiver
L2O48_16320	COG0419	ATPase involved in DNA repair
L2O48_16325	COG0420	3'-5' exonuclease activity
L2O48_16330	COG1609	Transcriptional regulator
L2O48_16335	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2O48_16335	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2O48_16340	COG1105	Belongs to the carbohydrate kinase PfkB family
L2O48_16345	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2O48_16345	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2O48_16345	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L2O48_16375	COG0404	The glycine cleavage system catalyzes the degradation of glycine
L2O48_16385	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L2O48_16390	COG0509	glycine decarboxylation via glycine cleavage system
L2O48_16410	COG1566	PFAM secretion protein HlyD family protein
L2O48_16440	COG0656	L-ascorbic acid biosynthetic process
L2O48_16445	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2O48_16455	COG0861	Integral membrane protein TerC family
L2O48_16465	COG2226	methyltransferase
L2O48_16475	COG1162	GTPase activity
L2O48_16480	COG2433	Pfam Transposase IS66
L2O48_16500	COG2433	Pfam Transposase IS66
L2O48_16535	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L2O48_16540	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L2O48_16545	COG4604	ABC transporter, ATP-binding protein
L2O48_16550	COG4605	iron ion homeostasis
L2O48_16555	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2O48_16560	COG4607	ABC-type enterochelin transport system periplasmic component
L2O48_16590	COG5380	lipid catabolic process
L2O48_16595	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
L2O48_16605	COG3240	lipase activity
L2O48_16620	COG0443	Heat shock 70 kDa protein
L2O48_16630	COG2814	Major facilitator Superfamily
L2O48_16640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2O48_16640	COG4191	Histidine kinase
L2O48_16645	COG3437	response regulator, receiver
L2O48_16645	COG0784	Response regulator, receiver
L2O48_16650	COG2207	Transcriptional regulator
L2O48_16655	COG0534	Mate efflux family protein
L2O48_16660	COG0840	transmembrane signaling receptor activity
L2O48_16665	COG2154	pterin-4-alpha-carbinolamine dehydratase
L2O48_16670	COG3186	Phenylalanine-4-hydroxylase
L2O48_16675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2O48_16680	COG0583	DNA-binding transcription factor activity
L2O48_16690	COG0583	DNA-binding transcription factor activity
L2O48_16705	COG0110	maltose O-acetyltransferase activity
L2O48_16710	COG1765	OsmC-like protein
L2O48_16715	COG0673	inositol 2-dehydrogenase activity
L2O48_16730	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2O48_16735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2O48_16750	COG2205	protein histidine kinase activity
L2O48_16750	COG5002	protein histidine kinase activity
L2O48_16750	COG0784	Response regulator, receiver
L2O48_16775	COG0531	amino acid
L2O48_16785	COG4999	Histidine kinase
L2O48_16785	COG3850	Histidine kinase
L2O48_16785	COG2205	protein histidine kinase activity
L2O48_16785	COG3437	response regulator, receiver
L2O48_16790	COG3437	response regulator, receiver
L2O48_16800	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
L2O48_16810	COG5001	Diguanylate cyclase
L2O48_16810	COG3706	GGDEF domain
L2O48_16810	COG4251	negative regulation of phosphorylation
L2O48_16810	COG2203	Gaf domain
L2O48_16815	COG3279	Response regulator of the LytR AlgR family
L2O48_16820	COG0745	RESPONSE REGULATOR receiver
L2O48_16820	COG2972	Histidine kinase
L2O48_16835	COG4591	ABC-type transport system involved in lipoprotein release permease component
L2O48_16840	COG0577	efflux transmembrane transporter activity
L2O48_16840	COG1136	(ABC) transporter
L2O48_16850	COG4989	oxidoreductase activity
L2O48_16860	COG0513	Belongs to the DEAD box helicase family
L2O48_16870	COG1376	ErfK ybiS ycfS ynhG family protein
L2O48_16870	COG1388	LysM domain
L2O48_16875	COG0415	Belongs to the DNA photolyase family
L2O48_16880	COG0789	Transcriptional regulator
L2O48_16885	COG3272	Protein of unknown function (DUF1722)
L2O48_16890	COG0813	purine-nucleoside phosphorylase activity
L2O48_16915	COG1566	PFAM secretion protein HlyD family protein
L2O48_16940	COG0786	glutamate:sodium symporter activity
L2O48_16955	COG1999	signal sequence binding
L2O48_16965	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
L2O48_16975	COG0366	Alpha amylase catalytic
L2O48_17035	COG0561	phosphatase activity
L2O48_17040	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
L2O48_17045	COG3623	hexulose-6-phosphate isomerase
L2O48_17065	COG1132	(ABC) transporter
L2O48_17075	COG0671	phosphoesterase, PA-phosphatase related
L2O48_17115	COG1131	(ABC) transporter
L2O48_17120	COG2188	Transcriptional regulator
L2O48_17130	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
L2O48_17135	COG0471	metal ion transport
L2O48_17190	COG3501	Rhs element vgr protein
L2O48_17215	COG3829	transcription factor binding
L2O48_17280	COG0564	pseudouridine synthase activity
L2O48_17290	COG0745	RESPONSE REGULATOR receiver
L2O48_17305	COG1309	transcriptional regulator
L2O48_17310	COG2130	NADP-dependent
L2O48_17320	COG1328	CTP reductase activity
L2O48_17325	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L2O48_17335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2O48_17340	COG0251	oxidation-reduction process
L2O48_17345	COG0513	Belongs to the DEAD box helicase family
L2O48_17365	COG1175	transmembrane transport
L2O48_17375	COG3842	ATPase activity
L2O48_17390	COG1131	(ABC) transporter
L2O48_17395	COG0842	Transport permease protein
L2O48_17400	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L2O48_17405	COG3046	protein related to deoxyribodipyrimidine photolyase
L2O48_17410	COG4943	cyclic-guanylate-specific phosphodiesterase activity
L2O48_17420	COG1846	Transcriptional regulator
L2O48_17445	COG2259	Doxx family
L2O48_17450	COG1301	dicarboxylic acid transport
L2O48_17455	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L2O48_17465	COG3722	fumarate hydratase activity
L2O48_17470	COG0246	Mannitol dehydrogenase
L2O48_17475	COG2213	PTS system mannitol-specific
L2O48_17475	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2O48_17480	COG0739	heme binding
L2O48_17490	COG0363	glucosamine-6-phosphate deaminase activity
L2O48_17510	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
L2O48_17515	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2O48_17530	COG3304	Inner membrane component domain
L2O48_17540	COG2910	NAD(P)H-binding
L2O48_17545	COG0583	DNA-binding transcription factor activity
L2O48_17585	COG0814	amino acid
L2O48_17590	COG2084	Dehydrogenase
L2O48_17645	COG1444	tRNA N-acetyltransferase activity
L2O48_17655	COG0745	RESPONSE REGULATOR receiver
L2O48_17660	COG0643	Histidine kinase
L2O48_17660	COG2198	Histidine kinase
L2O48_17665	COG0835	chemotaxis
L2O48_17675	COG0840	transmembrane signaling receptor activity
L2O48_17680	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L2O48_17685	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
L2O48_17735	COG0259	pyridoxamine-phosphate oxidase activity
L2O48_17745	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2O48_17805	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L2O48_17830	COG2909	trisaccharide binding
L2O48_17835	COG0058	SHG alpha-glucan phosphorylase activity
L2O48_17840	COG1640	4-alpha-glucanotransferase
L2O48_17845	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
L2O48_17855	COG3409	Peptidoglycan-binding domain 1 protein
L2O48_17855	COG3501	Rhs element vgr protein
L2O48_17870	COG1869	D-ribose catabolic process
L2O48_17875	COG1129	ABC transporter
L2O48_17880	COG1172	Belongs to the binding-protein-dependent transport system permease family
L2O48_17885	COG1879	ABC-type sugar transport system periplasmic component
L2O48_17890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2O48_17895	COG1609	Transcriptional regulator
L2O48_17920	COG0583	DNA-binding transcription factor activity
L2O48_17935	COG0363	glucosamine-6-phosphate deaminase activity
L2O48_17940	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L2O48_17950	COG1067	ATP-dependent peptidase activity
L2O48_17960	COG2211	Major facilitator Superfamily
L2O48_17980	COG4580	involved in the transport of maltose and maltodextrins
L2O48_17985	COG1609	Transcriptional regulator
L2O48_18000	COG0395	ABC-type sugar transport system, permease component
L2O48_18005	COG3842	ATPase activity
L2O48_18010	COG1472	Belongs to the glycosyl hydrolase 3 family
L2O48_18015	COG1609	Transcriptional regulator
L2O48_18045	COG3122	Protein conserved in bacteria
L2O48_18050	COG1881	PFAM PEBP family protein
L2O48_18070	COG1620	l-lactate permease
L2O48_18075	COG0583	DNA-binding transcription factor activity
L2O48_18100	COG3527	Alpha-acetolactate decarboxylase
L2O48_18110	COG0584	glycerophosphoryl diester phosphodiesterase
L2O48_18115	COG2271	Major facilitator Superfamily
L2O48_18130	COG3047	cAMP biosynthetic process
L2O48_18155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L2O48_18160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2O48_18170	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L2O48_18175	COG0573	inorganic phosphate transmembrane transporter activity
L2O48_18180	COG0581	inorganic phosphate transmembrane transporter activity
L2O48_18185	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L2O48_18200	COG3314	Sporulation integral membrane protein YlbJ
L2O48_18205	COG0659	secondary active sulfate transmembrane transporter activity
L2O48_18215	COG0739	heme binding
L2O48_18220	COG5001	Diguanylate cyclase
L2O48_18225	COG0583	DNA-binding transcription factor activity
L2O48_18230	COG2814	Major facilitator Superfamily
L2O48_18245	COG0697	spore germination
L2O48_18255	COG0179	Fumarylacetoacetate (FAA) hydrolase
L2O48_18275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2O48_18280	COG0765	amino acid transport
L2O48_18285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2O48_18290	COG0765	amino acid transport
L2O48_18300	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L2O48_18310	COG3123	guanosine phosphorylase activity
L2O48_18320	COG1741	Belongs to the pirin family
L2O48_18330	COG5001	Diguanylate cyclase
L2O48_18365	COG3706	GGDEF domain
L2O48_18370	COG2315	Protein conserved in bacteria
L2O48_18375	COG0835	chemotaxis
L2O48_18375	COG0784	Response regulator, receiver
L2O48_18380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2O48_18390	COG3842	ATPase activity
L2O48_18400	COG1175	transmembrane transport
L2O48_18405	COG3833	ABC-type maltose transport systems, permease component
L2O48_18430	COG1349	DNA-binding transcription factor activity
L2O48_18435	COG2199	diguanylate cyclase activity
L2O48_18480	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
L2O48_18485	COG2354	Protein conserved in bacteria
L2O48_18490	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L2O48_18495	COG0418	dihydroorotase activity
L2O48_18500	COG3217	Mosc domain protein beta barrel domain protein
L2O48_18500	COG0633	Ferredoxin
L2O48_18505	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L2O48_18510	COG2195	Cleaves the N-terminal amino acid of tripeptides
L2O48_18520	COG3604	Transcriptional regulator
L2O48_18530	COG4681	YaeQ
L2O48_18535	COG1278	Cold shock
L2O48_18560	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L2O48_18565	COG0516	GMP reductase activity
L2O48_18580	COG0589	response to stress
L2O48_18585	COG0659	secondary active sulfate transmembrane transporter activity
L2O48_18595	COG0798	PFAM Bile acid sodium symporter
L2O48_18600	COG0640	Transcriptional regulator
L2O48_18605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L2O48_18625	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
L2O48_18630	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L2O48_18640	COG2271	Major facilitator Superfamily
L2O48_18645	COG3851	Histidine kinase
L2O48_18650	COG2197	response regulator
L2O48_18665	COG0346	lactoylglutathione lyase activity
L2O48_18675	COG0156	8-amino-7-oxononanoate synthase activity
L2O48_18680	COG1063	alcohol dehydrogenase
L2O48_18685	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
L2O48_18695	COG1368	sulfuric ester hydrolase activity
L2O48_18700	COG3530	Putative quorum-sensing-regulated virulence factor
L2O48_18715	COG3706	GGDEF domain
L2O48_18730	COG2304	oxidoreductase activity
L2O48_18750	COG0714	Associated with various cellular activities
L2O48_18770	COG0366	Alpha amylase catalytic
L2O48_18805	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L2O48_18810	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
L2O48_18820	COG0456	acetyltransferase
L2O48_18825	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2O48_18830	COG0662	Cupin 2, conserved barrel domain protein
L2O48_18835	COG0527	aspartate kinase activity
L2O48_18840	COG2239	Acts as a magnesium transporter
L2O48_18855	COG2113	Glycine betaine
L2O48_18860	COG4176	ABC-type proline glycine betaine transport system permease component
L2O48_18875	COG1166	arginine decarboxylase activity
L2O48_18880	COG0010	Belongs to the arginase family
L2O48_18900	COG3300	MHYT domain
L2O48_18900	COG5001	Diguanylate cyclase
L2O48_18905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2O48_18930	COG3437	response regulator, receiver
L2O48_18930	COG0784	Response regulator, receiver
L2O48_18945	COG0484	heat shock protein binding
L2O48_18955	COG5001	Diguanylate cyclase
L2O48_18955	COG1716	ATPase activity
L2O48_18960	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L2O48_18970	COG4181	ATPase activity
L2O48_18975	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L2O48_18985	COG1984	allophanate hydrolase subunit 2
L2O48_18995	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
L2O48_19000	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2O48_19010	COG0814	amino acid
L2O48_19015	COG0513	Belongs to the DEAD box helicase family
L2O48_19025	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
L2O48_19040	COG2425	protein containing a von Willebrand factor type A (vWA) domain
L2O48_19055	COG0517	IMP dehydrogenase activity
L2O48_19055	COG4175	Glycine betaine
L2O48_19060	COG4176	ABC-type proline glycine betaine transport system permease component
L2O48_19095	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2O48_19110	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2O48_19115	COG4605	iron ion homeostasis
L2O48_19120	COG4607	ABC-type enterochelin transport system periplasmic component
L2O48_19125	COG4774	siderophore transport
L2O48_19130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2O48_19160	COG0076	glutamate decarboxylase activity
L2O48_19185	COG2433	Pfam Transposase IS66
L2O48_19200	COG1169	isochorismate synthase
L2O48_19205	COG1021	2,3-dihydroxybenzoate-AMP ligase
L2O48_19210	COG1535	isochorismatase
L2O48_19210	COG3433	isochorismatase activity
L2O48_19215	COG4604	ABC transporter, ATP-binding protein
L2O48_19275	COG1192	Involved in chromosome partitioning
L2O48_19300	COG3657	addiction module killer protein
L2O48_19325	COG2433	Pfam Transposase IS66
L2O48_19390	COG1028	Short-chain dehydrogenase reductase Sdr
L2O48_19410	COG4607	ABC-type enterochelin transport system periplasmic component
L2O48_19415	COG4605	iron ion homeostasis
L2O48_19420	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2O48_19435	COG1028	Short-chain dehydrogenase reductase Sdr
L2O48_19490	COG2433	Pfam Transposase IS66
L2O48_19510	COG3657	addiction module killer protein
L2O48_19600	COG1169	isochorismate synthase
L2O48_19605	COG1169	isochorismate synthase
L2O48_19640	COG1136	(ABC) transporter
L2O48_19640	COG0577	efflux transmembrane transporter activity
L2O48_19685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2O48_19690	COG4774	siderophore transport
L2O48_19695	COG4607	ABC-type enterochelin transport system periplasmic component
L2O48_19700	COG4605	iron ion homeostasis
L2O48_19705	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2O48_19720	COG1028	Short-chain dehydrogenase reductase Sdr