locus-tag	class	description
N175_00020	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
N175_00030	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
N175_00035	COG3118	belongs to the thioredoxin family
N175_00045	COG0248	Ppx GppA phosphatase
N175_00050	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
N175_00060	COG0194	GDP metabolic process
N175_00065	COG1758	RNA polymerase activity
N175_00070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N175_00075	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N175_00080	COG2233	PERMEase
N175_00090	COG0745	RESPONSE REGULATOR receiver
N175_00115	COG0583	DNA-binding transcription factor activity
N175_00140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N175_00145	COG2183	response to ionizing radiation
N175_00165	COG1040	competence protein
N175_00170	COG0316	Belongs to the HesB IscA family
N175_00170	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
N175_00175	COG0494	nUDIX hydrolase
N175_00180	COG1218	3'(2'),5'-bisphosphate nucleotidase
N175_00190	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
N175_00195	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
N175_00200	COG3156	type II secretion system protein K
N175_00205	COG4795	General secretion pathway protein
N175_00210	COG2165	general secretion pathway protein
N175_00215	COG2165	general secretion pathway protein
N175_00220	COG2165	general secretion pathway protein
N175_00225	COG1459	type II secretion system
N175_00230	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N175_00240	COG3031	protein transport across the cell outer membrane
N175_00245	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
N175_00250	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
N175_00260	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
N175_00270	COG0456	acetyltransferase
N175_00275	COG1490	D-aminoacyl-tRNA deacylase activity
N175_00290	COG0174	glutamine synthetase
N175_00300	COG3852	Histidine kinase
N175_00310	COG3300	MHYT domain
N175_00310	COG5001	Diguanylate cyclase
N175_00315	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N175_00355	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N175_00400	COG3550	peptidyl-serine autophosphorylation
N175_00440	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
N175_00475	COG3250	beta-galactosidase activity
N175_00490	COG0534	Mate efflux family protein
N175_00510	COG2937	Belongs to the GPAT DAPAT family
N175_00520	COG3161	chorismate lyase activity
N175_00525	COG1580	Controls the rotational direction of flagella during chemotaxis
N175_00530	COG0705	Rhomboid family
N175_00545	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N175_00550	COG2177	Part of the ABC transporter FtsEX involved in
N175_00555	COG2884	Cell division ATP-binding protein ftsE
N175_00560	COG0552	protein localization to endoplasmic reticulum
N175_00565	COG0742	ribosomal rna small subunit methyltransferase
N175_00575	COG2095	MarC family integral membrane protein
N175_00610	COG2433	Pfam Transposase IS66
N175_00615	COG2095	MarC family integral membrane protein
N175_00645	COG0783	Belongs to the Dps family
N175_00650	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
N175_00655	COG1280	lysine exporter protein (LysE YggA)
N175_00660	COG2267	carboxylic ester hydrolase activity
N175_00665	COG0561	phosphatase activity
N175_00685	COG1011	Hydrolase
N175_00690	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
N175_00705	COG0019	diaminopimelate decarboxylase activity
N175_00720	COG3072	Adenylate cyclase
N175_00730	COG1587	Uroporphyrinogen-III synthase
N175_00735	COG2959	enzyme of heme biosynthesis
N175_00740	COG3071	HemY protein
N175_00770	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
N175_00780	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N175_00785	COG0408	coproporphyrinogen oxidase activity
N175_00790	COG0009	L-threonylcarbamoyladenylate synthase
N175_00795	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
N175_00800	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
N175_00805	COG0551	DNA topoisomerase type I activity
N175_00810	COG2922	Belongs to the Smg family
N175_00815	COG0758	DNA mediated transformation
N175_00820	COG1652	LysM domain
N175_00825	COG0242	peptide deformylase activity
N175_00830	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
N175_00835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N175_00835	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N175_00840	COG0569	domain protein
N175_00845	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N175_00855	COG1272	protein, Hemolysin III
N175_00865	COG3084	Protein conserved in bacteria
N175_00875	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
N175_00880	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N175_00890	COG2433	Pfam Transposase IS66
N175_00965	COG0606	chelatase, subunit chli
N175_00975	COG3978	acetolactate synthase activity
N175_00980	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N175_00985	COG0129	dihydroxy-acid dehydratase activity
N175_00995	COG0604	alcohol dehydrogenase
N175_01020	COG2119	membrane
N175_01025	COG0752	glycyl-tRNA synthetase alpha subunit
N175_01035	COG3977	Valine--pyruvate aminotransferase
N175_01040	COG0071	Belongs to the small heat shock protein (HSP20) family
N175_01055	COG0187	DNA topoisomerase II activity
N175_01060	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
N175_01065	COG0592	DNA-directed DNA polymerase activity
N175_01085	COG1126	abc transporter atp-binding protein
N175_01100	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
N175_01105	COG0706	membrane insertase activity
N175_01115	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
N175_01120	COG0445	tRNA wobble uridine modification
N175_01130	COG1192	Involved in chromosome partitioning
N175_01135	COG1475	DNA binding
N175_01140	COG3312	ion transport
N175_01145	COG0356	it plays a direct role in the translocation of protons across the membrane
N175_01155	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
N175_01160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N175_01165	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
N175_01170	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
N175_01175	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
N175_01180	COG0355	proton-transporting ATP synthase activity, rotational mechanism
N175_01190	COG2814	Major facilitator Superfamily
N175_01195	COG0583	DNA-binding transcription factor activity
N175_01200	COG0183	Belongs to the thiolase family
N175_01210	COG1739	Uncharacterized protein family UPF0029
N175_01215	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N175_01220	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
N175_01270	COG0352	thiamine-phosphate diphosphorylase activity
N175_01280	COG2104	thiamine diphosphate biosynthetic process
N175_01290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
N175_01295	COG0006	proline dipeptidase activity
N175_01295	COG0006	proline dipeptidase activity
N175_01320	COG1522	sequence-specific DNA binding
N175_01325	COG0742	ribosomal rna small subunit methyltransferase
N175_01335	COG0697	spore germination
N175_01340	COG0589	response to stress
N175_01345	COG1528	Iron-storage protein
N175_01360	COG2081	HI0933 family
N175_01370	COG1172	Belongs to the binding-protein-dependent transport system permease family
N175_01375	COG1129	ABC transporter
N175_01380	COG1879	ABC-type sugar transport system periplasmic component
N175_01385	COG1069	ribulokinase activity
N175_01395	COG2160	L-arabinose isomerase activity
N175_01415	COG1322	Protein conserved in bacteria
N175_01430	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N175_01440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N175_01445	COG0805	protein transport
N175_01450	COG0084	hydrolase, TatD family'
N175_01460	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N175_01460	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N175_01465	COG0218	Necessary for normal cell division and for the maintenance of normal septation
N175_01490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N175_01495	COG0583	DNA-binding transcription factor activity
N175_01505	COG2960	long-chain fatty acid transporting porin activity
N175_01510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N175_01515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N175_01520	COG1309	transcriptional regulator
N175_01580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N175_01635	COG2433	Pfam Transposase IS66
N175_01655	COG3081	Nucleoid-associated protein
N175_01680	COG2433	Pfam Transposase IS66
N175_01690	COG5290	Psort location Cytoplasmic, score
N175_01730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N175_01735	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
N175_01740	COG0339	signal peptide processing
N175_01745	COG0210	DNA helicase
N175_01755	COG1280	lysine exporter protein (LysE YggA)
N175_01765	COG2962	Rard protein
N175_01770	COG0514	ATP-dependent DNA helicase (RecQ)
N175_01790	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
N175_01795	COG1263	PTS System
N175_01795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N175_01800	COG1132	(ABC) transporter
N175_01805	COG4774	siderophore transport
N175_01810	COG1120	ATPase activity
N175_01840	COG0612	Peptidase, M16
N175_01935	COG1561	YicC-like family, N-terminal region
N175_01940	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
N175_01950	COG1560	Kdo2-lipid A biosynthetic process
N175_01955	COG1560	Kdo2-lipid A biosynthetic process
N175_01960	COG1309	transcriptional regulator
N175_01965	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N175_01980	COG0267	Belongs to the bacterial ribosomal protein bL33 family
N175_01990	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N175_01995	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
N175_02000	COG0859	PFAM glycosyl transferase family 9
N175_02005	COG0463	Glycosyl transferase, family 2
N175_02010	COG0859	PFAM glycosyl transferase family 9
N175_02015	COG3642	lipopolysaccharide core region biosynthetic process
N175_02030	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
N175_02040	COG1519	Transferase
N175_02055	COG0859	PFAM glycosyl transferase family 9
N175_02060	COG3307	-O-antigen
N175_02070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N175_02095	COG1682	transport, permease protein
N175_02110	COG5433	transposase activity
N175_02115	COG5433	transposase activity
N175_02135	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
N175_02150	COG0028	Belongs to the TPP enzyme family
N175_02160	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
N175_02165	COG0463	Glycosyl transferase, family 2
N175_02195	COG3754	Rhamnan synthesis protein F
N175_02220	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N175_02230	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N175_02250	COG1596	polysaccharide export
N175_02255	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N175_02295	COG0438	transferase activity, transferring glycosyl groups
N175_02310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N175_02315	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
N175_02320	COG0840	transmembrane signaling receptor activity
N175_02325	COG0668	transmembrane transport
N175_02330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N175_02335	COG3068	Protein conserved in bacteria
N175_02340	COG2852	Protein conserved in bacteria
N175_02345	COG1253	flavin adenine dinucleotide binding
N175_02355	COG0776	regulation of translation
N175_02365	COG0151	Belongs to the GarS family
N175_02380	COG0789	Transcriptional regulator
N175_02385	COG0840	transmembrane signaling receptor activity
N175_02390	COG0840	transmembrane signaling receptor activity
N175_02400	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
N175_02405	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N175_02415	COG2264	protein methyltransferase activity
N175_02420	COG0439	Biotin carboxylase
N175_02425	COG0511	ligase activity, forming carbon-carbon bonds
N175_02430	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
N175_02435	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N175_02450	COG2814	Major facilitator Superfamily
N175_02455	COG0784	Response regulator, receiver
N175_02455	COG2205	protein histidine kinase activity
N175_02455	COG2198	Histidine kinase
N175_02460	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N175_02470	COG3263	regulation of cellular component size
N175_02480	COG4232	protein-disulfide reductase activity
N175_02485	COG1438	arginine binding
N175_02490	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
N175_02495	COG0540	Belongs to the ATCase OTCase family
N175_02505	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
N175_02510	COG0549	Belongs to the carbamate kinase family
N175_02520	COG1288	antiporter activity
N175_02525	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
N175_02530	COG1027	Aspartate ammonia-lyase
N175_02535	COG3030	protein affecting phage T7 exclusion by the F plasmid
N175_02540	COG1278	Cold shock
N175_02545	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
N175_02550	COG2205	protein histidine kinase activity
N175_02555	COG0745	RESPONSE REGULATOR receiver
N175_02565	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
N175_02570	COG0205	6-phosphofructokinase activity
N175_02575	COG1494	fructose-1,6-bisphosphatase
N175_02585	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
N175_02590	COG0460	homoserine dehydrogenase
N175_02590	COG0527	aspartate kinase activity
N175_02595	COG0626	cystathionine gamma-synthase activity
N175_02605	COG0281	malic enzyme
N175_02615	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
N175_02620	COG1609	Transcriptional regulator
N175_02640	COG1575	Belongs to the MenA family. Type 1 subfamily
N175_02645	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N175_02650	COG0534	Mate efflux family protein
N175_02655	COG0149	triose-phosphate isomerase activity
N175_02685	COG0459	protein refolding
N175_02700	COG1509	lysine 2,3-aminomutase activity
N175_02705	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N175_02715	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
N175_02720	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N175_02725	COG1053	succinate dehydrogenase
N175_02730	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
N175_02735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N175_02745	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
N175_02750	COG1045	serine acetyltransferase
N175_02770	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
N175_02775	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N175_02780	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
N175_02780	COG0165	Argininosuccinate lyase
N175_02790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N175_02795	COG0678	peroxiredoxin activity
N175_02795	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N175_02805	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
N175_02835	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
N175_02850	COG0338	D12 class N6 adenine-specific DNA methyltransferase
N175_02855	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N175_02860	COG0546	phosphoglycolate phosphatase activity
N175_02865	COG0180	Tryptophanyl-tRNA synthetase
N175_02880	COG0583	DNA-binding transcription factor activity
N175_02890	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N175_02905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N175_02925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N175_02930	COG3954	Phosphoribulokinase
N175_02940	COG0429	hydrolase of the alpha beta-hydrolase fold
N175_02950	COG0488	(ABC) transporter
N175_02955	COG2249	NAD(P)H dehydrogenase (quinone) activity
N175_02965	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
N175_02970	COG1047	Peptidyl-prolyl cis-trans
N175_02980	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N175_02985	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
N175_02990	COG0557	exoribonuclease II activity
N175_02995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N175_03000	COG0051	transcription antitermination factor activity, RNA binding
N175_03025	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N175_03050	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
N175_03055	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
N175_03075	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
N175_03080	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
N175_03105	COG0201	protein transport
N175_03115	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N175_03120	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
N175_03125	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N175_03135	COG0203	ribosomal protein L17
N175_03140	COG0545	Peptidyl-prolyl cis-trans isomerase
N175_03145	COG3266	domain, Protein
N175_03145	COG3061	Opacity-associated protein A
N175_03150	COG2153	protein acetylation
N175_03155	COG0513	Belongs to the DEAD box helicase family
N175_03195	COG0737	Belongs to the 5'-nucleotidase family
N175_03200	COG1648	precorrin-2 dehydrogenase activity
N175_03200	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
N175_03205	COG0175	sulfate reduction
N175_03210	COG2895	sulfate adenylyltransferase (ATP) activity
N175_03215	COG0529	Catalyzes the synthesis of activated sulfate
N175_03250	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
N175_03255	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N175_03265	COG0729	surface antigen
N175_03270	COG2911	Protein conserved in bacteria
N175_03275	COG2105	PFAM AIG2 family protein
N175_03285	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
N175_03290	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
N175_03295	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N175_03300	COG0163	prenyltransferase activity
N175_03305	COG4143	(ABC) transporter
N175_03310	COG1178	ABC-type Fe3 transport system permease component
N175_03315	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
N175_03320	COG3028	Belongs to the UPF0307 family
N175_03325	COG0312	modulator of DNA gyrase
N175_03330	COG2239	Acts as a magnesium transporter
N175_03335	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N175_03345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N175_03350	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
N175_03360	COG1137	ATPase activity
N175_03365	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
N175_03375	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
N175_03380	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
N175_03380	COG0517	IMP dehydrogenase activity
N175_03395	COG1127	ABC transporter
N175_03400	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
N175_03405	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
N175_03410	COG2854	intermembrane phospholipid transfer
N175_03420	COG5007	Belongs to the BolA IbaG family
N175_03425	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N175_03430	COG0204	Acyl-transferase
N175_03445	COG0251	oxidation-reduction process
N175_03450	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
N175_03465	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
N175_03475	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N175_03485	COG0564	pseudouridine synthase activity
N175_03490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N175_03495	COG0525	valine-tRNA ligase activity
N175_03500	COG2927	DNA polymerase III (CHI subunit)
N175_03505	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N175_03510	COG0795	lipopolysaccharide-transporting ATPase activity
N175_03515	COG0795	lipopolysaccharide-transporting ATPase activity
N175_03615	COG0066	3-isopropylmalate dehydratase activity
N175_03625	COG0473	3-isopropylmalate dehydrogenase activity
N175_03630	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N175_03645	COG0583	DNA-binding transcription factor activity
N175_03650	COG1022	Amp-dependent synthetase and ligase
N175_03655	COG0028	Belongs to the TPP enzyme family
N175_03665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N175_03675	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N175_03680	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
N175_03690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N175_03695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N175_03710	COG0354	folic acid binding
N175_03715	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
N175_03725	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
N175_03730	COG1595	DNA-templated transcription, initiation
N175_03745	COG3086	response to oxidative stress
N175_03750	COG0481	GTPase activity
N175_03755	COG0681	Belongs to the peptidase S26 family
N175_03780	COG0736	holo-[acyl-carrier-protein] synthase activity
N175_03785	COG3437	response regulator, receiver
N175_03785	COG4999	Histidine kinase
N175_03785	COG3850	Histidine kinase
N175_03785	COG2205	protein histidine kinase activity
N175_03790	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N175_03795	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N175_03800	COG3956	TIGRFAM MazG family protein
N175_03805	COG0504	CTP synthase activity
N175_03815	COG0617	tRNA 3'-terminal CCA addition
N175_03820	COG3409	Peptidoglycan-binding domain 1 protein
N175_03820	COG3267	Type II secretory pathway component ExeA
N175_03830	COG4991	sh3 domain protein
N175_03835	COG0306	phosphate transporter
N175_03840	COG1392	Phosphate transport regulator
N175_03850	COG3025	triphosphatase activity
N175_03865	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
N175_03870	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
N175_03880	COG1538	Outer membrane efflux protein
N175_03885	COG0494	nUDIX hydrolase
N175_03890	COG3151	Protein conserved in bacteria
N175_03900	COG3150	esterase
N175_03905	COG0187	DNA topoisomerase II activity
N175_03910	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N175_03915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N175_03920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N175_03925	COG3105	Protein conserved in bacteria
N175_03930	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
N175_03950	COG0723	plastoquinol--plastocyanin reductase activity
N175_03955	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
N175_03960	COG2857	Cytochrome c1
N175_03965	COG0625	glutathione transferase activity
N175_03970	COG2969	positive regulation of protein catabolic process
N175_03980	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
N175_03990	COG3107	peptidoglycan biosynthetic process
N175_03995	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
N175_04010	COG3116	cell division
N175_04015	COG0768	penicillin binding
N175_04020	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N175_04025	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N175_04030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N175_04035	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
N175_04040	COG0772	Belongs to the SEDS family
N175_04045	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
N175_04050	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N175_04055	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
N175_04060	COG0849	cell division
N175_04065	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N175_04070	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
N175_04080	COG0653	protein targeting
N175_04085	COG0494	nUDIX hydrolase
N175_04100	COG0505	Belongs to the CarA family
N175_04110	COG0730	response to heat
N175_04115	COG0583	DNA-binding transcription factor activity
N175_04120	COG2860	membrane
N175_04125	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
N175_04150	COG0493	'glutamate synthase
N175_04155	COG0069	glutamate synthase activity
N175_04155	COG0067	glutamate synthase
N175_04155	COG0070	glutamate synthase
N175_04165	COG0069	glutamate synthase activity
N175_04165	COG0070	glutamate synthase
N175_04165	COG0067	glutamate synthase
N175_04170	COG1242	4 iron, 4 sulfur cluster binding
N175_04175	COG5002	protein histidine kinase activity
N175_04175	COG2198	Histidine kinase
N175_04175	COG0784	Response regulator, receiver
N175_04185	COG0745	RESPONSE REGULATOR receiver
N175_04190	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N175_04205	COG0083	homoserine kinase activity
N175_04210	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
N175_04215	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
N175_04220	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
N175_04225	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
N175_04240	COG1115	amino acid carrier protein
N175_04260	COG0084	hydrolase, TatD family'
N175_04265	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
N175_04270	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
N175_04280	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
N175_04285	COG0813	purine-nucleoside phosphorylase activity
N175_04295	COG0560	Phosphoserine phosphatase
N175_04305	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
N175_04310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N175_04315	COG4628	conserved protein (DUF2132)
N175_04320	COG1022	Amp-dependent synthetase and ligase
N175_04325	COG0784	Response regulator, receiver
N175_04325	COG3437	response regulator, receiver
N175_04335	COG0534	Mate efflux family protein
N175_04345	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N175_04350	COG1085	galactose-1-phosphate uridylyltransferase
N175_04360	COG2017	converts alpha-aldose to the beta-anomer
N175_04365	COG1609	Transcriptional regulator
N175_04395	COG2171	N-acyltransferase activity
N175_04400	COG3141	response to X-ray
N175_04415	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
N175_04420	COG1074	ATP-dependent DNA helicase activity
N175_04425	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N175_04435	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N175_04435	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
N175_04445	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
N175_04450	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
N175_04455	COG2166	iron-sulfur cluster assembly
N175_04460	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N175_04470	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
N175_04485	COG1595	DNA-templated transcription, initiation
N175_04495	COG2211	Major facilitator Superfamily
N175_04515	COG0271	Belongs to the BolA IbaG family
N175_04550	COG1477	protein flavinylation
N175_04560	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N175_04575	COG5001	Diguanylate cyclase
N175_04575	COG4251	negative regulation of phosphorylation
N175_04575	COG3706	GGDEF domain
N175_04575	COG2203	Gaf domain
N175_04580	COG0733	neurotransmitter:sodium symporter activity
N175_04590	COG0189	ligase activity
N175_04595	COG0189	ligase activity
N175_04595	COG4067	protein conserved in archaea
N175_04600	COG2195	Cleaves the N-terminal amino acid of tripeptides
N175_04610	COG2252	PERMEase
N175_04630	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
N175_04635	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
N175_04645	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N175_04645	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N175_04670	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
N175_04675	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
N175_04690	COG0024	Methionine aminopeptidase
N175_04695	COG0052	Belongs to the universal ribosomal protein uS2 family
N175_04700	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
N175_04710	COG0233	cytoplasmic translational termination
N175_04715	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N175_04720	COG0575	Belongs to the CDS family
N175_04725	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
N175_04730	COG0750	zinc metalloprotease
N175_04740	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
N175_04745	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N175_04750	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N175_04760	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N175_04770	COG0587	DNA-directed DNA polymerase activity
N175_04775	COG0825	malonyl-CoA metabolic process
N175_04780	COG0037	tRNA processing
N175_04795	COG0347	Belongs to the P(II) protein family
N175_04810	COG1388	LysM domain
N175_04810	COG0741	lytic transglycosylase activity
N175_04815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N175_04820	COG2226	methyltransferase
N175_04830	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N175_04845	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
N175_04850	COG0121	glutamine amidotransferase
N175_04855	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
N175_04860	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
N175_04865	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
N175_04870	COG1187	pseudouridine synthase activity
N175_04900	COG2608	mercury ion transmembrane transporter activity
N175_04900	COG2217	Heavy metal translocating P-type atpase
N175_04945	COG2747	anti-sigma28 factor FlgM
N175_04955	COG0835	chemotaxis
N175_04955	COG0784	Response regulator, receiver
N175_04965	COG1815	bacterial-type flagellum-dependent cell motility
N175_04970	COG1558	bacterial-type flagellum-dependent cell motility
N175_04975	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
N175_04985	COG1749	Flagellar hook protein flgE
N175_04990	COG4787	bacterial-type flagellum-dependent cell motility
N175_04995	COG4786	Flagellar basal body rod
N175_05000	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
N175_05005	COG1706	bacterial-type flagellum-dependent cell motility
N175_05010	COG3951	Flagellar rod assembly protein muramidase FlgJ
N175_05010	COG1705	Flagellar rod assembly protein muramidase FlgJ
N175_05020	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N175_05110	COG0193	aminoacyl-tRNA hydrolase activity
N175_05125	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
N175_05130	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
N175_05135	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
N175_05140	COG2890	protein-(glutamine-N5) methyltransferase activity
N175_05145	COG3094	Invasion gene expression up-regulator, SirB
N175_05150	COG2912	Transglutaminase-like superfamily
N175_05155	COG2877	3-deoxy-8-phosphooctulonate synthase activity
N175_05165	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
N175_05170	COG2233	PERMEase
N175_05190	COG1393	Belongs to the ArsC family
N175_05195	COG4783	chaperone-mediated protein folding
N175_05215	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
N175_05225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N175_05245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N175_05250	COG1393	Belongs to the ArsC family
N175_05275	COG2837	iron assimilation
N175_05300	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
N175_05310	COG1516	flagellar protein fliS
N175_05315	COG2204	response regulator
N175_05320	COG4191	Histidine kinase
N175_05325	COG2204	response regulator
N175_05330	COG1677	Flagellar hook-basal body complex protein FliE
N175_05340	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N175_05390	COG1987	bacterial-type flagellum assembly
N175_05395	COG1684	flagellar biosynthetic protein fliR
N175_05405	COG2840	Smr protein MutS2
N175_05410	COG2890	protein-(glutamine-N5) methyltransferase activity
N175_05415	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
N175_05420	COG2860	membrane
N175_05425	COG3101	peptidyl-lysine hydroxylation
N175_05435	COG0431	NADPH-dependent FMN reductase
N175_05440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N175_05440	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
N175_05445	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N175_05450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N175_05455	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N175_05460	COG0735	belongs to the Fur family
N175_05470	COG0583	DNA-binding transcription factor activity
N175_05480	COG1346	cytolysis
N175_05485	COG0716	FMN binding
N175_05495	COG0596	Alpha beta hydrolase
N175_05500	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
N175_05505	COG0033	Phosphoglucomutase
N175_05515	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N175_05525	COG2009	succinate dehydrogenase
N175_05530	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
N175_05545	COG0567	Dehydrogenase, E1 component
N175_05550	COG0508	dehydrogenase complex catalyzes the overall conversion of
N175_05565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N175_05570	COG1121	(ABC) transporter
N175_05575	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
N175_05580	COG4977	sequence-specific DNA binding
N175_05585	COG1918	ferrous iron import across plasma membrane
N175_05610	COG3102	Protein conserved in bacteria
N175_05615	COG1025	Belongs to the peptidase M16 family
N175_05620	COG2062	phosphohistidine phosphatase, SixA
N175_05625	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
N175_05635	COG0455	bacterial-type flagellum organization
N175_05650	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
N175_05655	COG2198	Histidine kinase
N175_05655	COG0643	Histidine kinase
N175_05660	COG2201	protein-glutamate methylesterase activity
N175_05665	COG1192	Involved in chromosome partitioning
N175_05675	COG0835	chemotaxis
N175_05685	COG4133	protoheme IX ABC transporter activity
N175_05690	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N175_05695	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N175_05705	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
N175_05710	COG1138	Cytochrome C-type biogenesis protein
N175_05715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N175_05730	COG2853	Lipoprotein
N175_05750	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
N175_05755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N175_05780	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
N175_05785	COG0243	molybdopterin cofactor binding
N175_05795	COG3083	sulfuric ester hydrolase activity
N175_05800	COG3082	Protein of unknown function (DUF1414)
N175_05815	COG1757	Na H antiporter
N175_05820	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N175_05825	COG2095	MarC family integral membrane protein
N175_05830	COG1012	belongs to the aldehyde dehydrogenase family
N175_05830	COG1454	alcohol dehydrogenase
N175_05840	COG1530	ribonuclease E activity
N175_05845	COG0564	pseudouridine synthase activity
N175_05850	COG0424	maF-like protein
N175_05855	COG1399	metal-binding, possibly nucleic acid-binding protein
N175_05860	COG0333	Belongs to the bacterial ribosomal protein bL32 family
N175_05870	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N175_05895	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N175_05900	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
N175_05905	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
N175_05910	COG0470	DNA polymerase III
N175_05915	COG0084	hydrolase, TatD family'
N175_05920	COG1263	PTS System
N175_05920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N175_05930	COG0733	neurotransmitter:sodium symporter activity
N175_05945	COG4667	esterase of the alpha-beta hydrolase superfamily
N175_05955	COG1940	carbohydrate kinase activity
N175_05960	COG0835	chemotaxis
N175_05960	COG0784	Response regulator, receiver
N175_05965	COG1028	Short-chain dehydrogenase reductase Sdr
N175_05970	COG0616	signal peptide processing
N175_05985	COG0232	Belongs to the dGTPase family. Type 2 subfamily
N175_05990	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
N175_05995	COG0436	Aminotransferase
N175_06000	COG1169	isochorismate synthase
N175_06005	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
N175_06015	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
N175_06020	COG1441	menaquinone biosynthetic process
N175_06065	COG1522	sequence-specific DNA binding
N175_06070	COG1946	Acyl-CoA thioesterase
N175_06090	COG3706	GGDEF domain
N175_06110	COG1022	Amp-dependent synthetase and ligase
N175_06120	COG4221	oxidoreductase activity
N175_06130	COG0745	RESPONSE REGULATOR receiver
N175_06135	COG0642	Histidine kinase
N175_06140	COG2194	sulfuric ester hydrolase activity
N175_06155	COG2985	domain, Protein
N175_06165	COG3850	Histidine kinase
N175_06165	COG5002	protein histidine kinase activity
N175_06180	COG1609	Transcriptional regulator
N175_06185	COG0129	dihydroxy-acid dehydratase activity
N175_06190	COG3265	gluconokinase activity
N175_06195	COG2610	gluconate transmembrane transporter activity
N175_06200	COG0800	Aldolase
N175_06225	COG1028	Short-chain dehydrogenase reductase Sdr
N175_06230	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N175_06235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N175_06265	COG1216	Glycosyl transferase, family 2
N175_06285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N175_06290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N175_06315	COG0784	Response regulator, receiver
N175_06315	COG5002	protein histidine kinase activity
N175_06330	COG0601	transmembrane transport
N175_06335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N175_06340	COG0444	Belongs to the ABC transporter superfamily
N175_06350	COG0435	Glutathione S-transferase
N175_06355	COG0280	phosphate acetyltransferase
N175_06355	COG0857	belongs to the CobB CobQ family
N175_06360	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N175_06365	COG3092	negative regulation of chromosome organization
N175_06375	COG4120	Belongs to the binding-protein-dependent transport system permease family
N175_06385	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N175_06390	COG0653	protein targeting
N175_06395	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
N175_06400	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N175_06410	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
N175_06420	COG0156	8-amino-7-oxononanoate synthase activity
N175_06425	COG2226	methyltransferase
N175_06430	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
N175_06440	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N175_06445	COG2186	Transcriptional regulator
N175_06460	COG0537	adenosine 5'-monophosphoramidase activity
N175_06490	COG1252	NADH dehydrogenase
N175_06505	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N175_06515	COG4591	ABC-type transport system involved in lipoprotein release permease component
N175_06520	COG1136	(ABC) transporter
N175_06525	COG4591	ABC-type transport system involved in lipoprotein release permease component
N175_06535	COG0658	competence protein
N175_06535	COG2333	competence protein COMEC
N175_06540	COG1132	(ABC) transporter
N175_06555	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
N175_06565	COG2719	SpoVR family
N175_06570	COG2718	Belongs to the UPF0229 family
N175_06575	COG2766	serine protein kinase
N175_06590	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
N175_06605	COG1882	Formate acetyltransferase
N175_06630	COG4215	(ABC) transporter
N175_06635	COG4160	amino acid transport
N175_06640	COG0708	Exodeoxyribonuclease III
N175_06645	COG0840	transmembrane signaling receptor activity
N175_06655	COG3923	Primosomal replication protein n
N175_06665	COG1199	ATP-dependent helicase activity
N175_06675	COG3012	SEC-C Motif Domain Protein
N175_06680	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
N175_06685	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N175_06690	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
N175_06695	COG0215	cysteine-tRNA ligase activity
N175_06700	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
N175_06705	COG0632	four-way junction helicase activity
N175_06710	COG2255	four-way junction helicase activity
N175_06720	COG1271	oxidase subunit
N175_06725	COG1294	oxidase, subunit
N175_06730	COG4890	Cyd operon protein YbgT
N175_06735	COG3790	cyd operon protein YbgE
N175_06740	COG0824	Thioesterase
N175_06745	COG0811	peptide transport
N175_06765	COG2885	chlorophyll binding
N175_06770	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
N175_06780	COG2433	Pfam Transposase IS66
N175_06800	COG5002	protein histidine kinase activity
N175_06800	COG0784	Response regulator, receiver
N175_06830	COG1401	restriction endodeoxyribonuclease activity
N175_06855	COG5001	Diguanylate cyclase
N175_06855	COG3300	MHYT domain
N175_06880	COG1960	acyl-CoA dehydrogenase activity
N175_06885	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
N175_06915	COG0277	FAD linked oxidase domain protein
N175_06915	COG0247	lactate metabolic process
N175_06930	COG2986	histidine ammonia-lyase
N175_06940	COG0010	Belongs to the arginase family
N175_06945	COG1228	amidohydrolase
N175_06960	COG3099	Belongs to the UPF0263 family
N175_06965	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N175_06975	COG0417	DNA replication proofreading
N175_06980	COG2197	response regulator
N175_06985	COG0322	excinuclease ABC activity
N175_07030	COG0072	phenylalanine-tRNA ligase activity
N175_07030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N175_07045	COG0500	methyltransferase
N175_07055	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
N175_07060	COG5001	Diguanylate cyclase
N175_07065	COG0295	cytidine deaminase activity
N175_07070	COG1346	cytolysis
N175_07080	COG2925	Exonuclease
N175_07090	COG0702	epimerase
N175_07120	COG2994	toxin metabolic process
N175_07125	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
N175_07125	COG1073	alpha beta
N175_07125	COG3064	Membrane
N175_07135	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
N175_07150	COG2988	succinylglutamate desuccinylase activity
N175_07155	COG4139	cobalamin transport
N175_07180	COG0583	DNA-binding transcription factor activity
N175_07190	COG1451	nucleotide metabolic process
N175_07205	COG3063	Type IV pilus biogenesis stability protein PilW
N175_07230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N175_07245	COG3290	protein histidine kinase activity
N175_07250	COG4565	transcriptional regulatory protein
N175_07260	COG0835	chemotaxis
N175_07260	COG0784	Response regulator, receiver
N175_07275	COG3706	GGDEF domain
N175_07275	COG0745	RESPONSE REGULATOR receiver
N175_07300	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
N175_07330	COG3501	Rhs element vgr protein
N175_07380	COG1181	Belongs to the D-alanine--D-alanine ligase family
N175_07400	COG1716	ATPase activity
N175_07425	COG3064	Membrane
N175_07425	COG4991	sh3 domain protein
N175_07425	COG0515	serine threonine protein kinase
N175_07475	COG2433	Pfam Transposase IS66
N175_07495	COG0251	oxidation-reduction process
N175_07505	COG1294	oxidase, subunit
N175_07525	COG3220	belongs to the UPF0276 family
N175_07550	COG0840	transmembrane signaling receptor activity
N175_07560	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N175_07565	COG2200	EAL domain
N175_07570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N175_07575	COG1263	PTS System
N175_07575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N175_07585	COG1621	beta-fructofuranosidase activity
N175_07605	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
N175_07610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N175_07620	COG0848	biopolymer transport protein
N175_07625	COG0811	peptide transport
N175_07630	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
N175_07635	COG3721	Heme iron utilization protein
N175_07640	COG0748	coenzyme F420 binding
N175_07645	COG4771	TonB-dependent receptor
N175_07645	COG1629	transport
N175_07650	COG1940	carbohydrate kinase activity
N175_07680	COG2989	Protein conserved in bacteria
N175_07685	COG3108	Peptidase M15
N175_07690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N175_07705	COG1846	Transcriptional regulator
N175_07710	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N175_07715	COG0840	transmembrane signaling receptor activity
N175_07725	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
N175_07730	COG1448	Aminotransferase
N175_07735	COG2770	Histidine kinase
N175_07735	COG3437	response regulator, receiver
N175_07740	COG0840	transmembrane signaling receptor activity
N175_07745	COG0745	RESPONSE REGULATOR receiver
N175_07755	COG2198	Histidine kinase
N175_07755	COG0643	Histidine kinase
N175_07765	COG0835	chemotaxis
N175_07770	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
N175_07775	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
N175_07780	COG2201	protein-glutamate methylesterase activity
N175_07790	COG0017	Asparaginyl-tRNA synthetase
N175_07795	COG0840	transmembrane signaling receptor activity
N175_07800	COG0720	synthase
N175_07805	COG2356	endonuclease I
N175_07815	COG1760	l-serine dehydratase
N175_07820	COG0814	amino acid
N175_07825	COG0494	nUDIX hydrolase
N175_07830	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N175_07845	COG3106	COG3106 Predicted ATPase
N175_07850	COG3768	UPF0283 membrane protein
N175_07855	COG3283	Transcriptional regulator of aromatic amino acids metabolism
N175_07860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N175_07870	COG3706	GGDEF domain
N175_07880	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N175_07890	COG0471	metal ion transport
N175_07895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N175_07895	COG4191	Histidine kinase
N175_07910	COG1278	Cold shock
N175_07915	COG3005	denitrification pathway
N175_07920	COG0513	Belongs to the DEAD box helicase family
N175_07925	COG2723	6-phospho-beta-galactosidase activity
N175_07930	COG1609	Transcriptional regulator
N175_07960	COG0443	Heat shock 70 kDa protein
N175_07975	COG5001	Diguanylate cyclase
N175_07975	COG5002	protein histidine kinase activity
N175_07995	COG1643	Atp-dependent helicase
N175_08005	COG0583	DNA-binding transcription factor activity
N175_08010	COG0477	Major facilitator Superfamily
N175_08025	COG0673	inositol 2-dehydrogenase activity
N175_08030	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N175_08035	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
N175_08035	COG0517	IMP dehydrogenase activity
N175_08040	COG2176	DNA-directed DNA polymerase activity
N175_08050	COG3718	enzyme involved in inositol metabolism
N175_08055	COG3962	Belongs to the TPP enzyme family
N175_08060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N175_08085	COG0673	inositol 2-dehydrogenase activity
N175_08090	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
N175_08165	COG1204	response to ionizing radiation
N175_08185	COG2433	Pfam Transposase IS66
N175_08195	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
N175_08200	COG1280	lysine exporter protein (LysE YggA)
N175_08205	COG1115	amino acid carrier protein
N175_08220	COG2195	Cleaves the N-terminal amino acid of tripeptides
N175_08230	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
N175_08240	COG0625	glutathione transferase activity
N175_08270	COG0811	peptide transport
N175_08275	COG0811	peptide transport
N175_08280	COG0848	biopolymer transport protein
N175_08295	COG4667	esterase of the alpha-beta hydrolase superfamily
N175_08300	COG1793	dna ligase
N175_08325	COG0791	NLP P60 protein
N175_08330	COG0840	transmembrane signaling receptor activity
N175_08355	COG1763	Mo-molybdopterin cofactor biosynthetic process
N175_08360	COG0746	molybdenum cofactor guanylyltransferase activity
N175_08365	COG3842	ATPase activity
N175_08375	COG1840	ABC-type Fe3 transport system, periplasmic component
N175_08380	COG2271	Major facilitator Superfamily
N175_08390	COG2197	response regulator
N175_08395	COG0488	(ABC) transporter
N175_08400	COG0004	ammonium transporteR
N175_08405	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
N175_08410	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
N175_08415	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
N175_08420	COG1177	transmembrane transport
N175_08425	COG1176	ABC-type spermidine putrescine transport system, permease component I
N175_08430	COG3842	ATPase activity
N175_08455	COG0589	response to stress
N175_08460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N175_08475	COG2217	Heavy metal translocating P-type atpase
N175_08485	COG2010	Cytochrome c
N175_08500	COG3278	Belongs to the heme-copper respiratory oxidase family
N175_08525	COG3120	sequence-specific DNA binding
N175_08530	COG1067	ATP-dependent peptidase activity
N175_08535	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N175_08560	COG0116	Belongs to the methyltransferase superfamily
N175_08560	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
N175_08570	COG0167	dihydroorotate dehydrogenase activity
N175_08575	COG2902	Dehydrogenase
N175_08585	COG0308	aminopeptidase N
N175_08605	COG1956	GAF domain-containing protein
N175_08610	COG1132	(ABC) transporter
N175_08615	COG2995	paraquat-inducible protein a
N175_08620	COG3008	intermembrane lipid transfer
N175_08630	COG2996	Protein conserved in bacteria
N175_08650	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N175_08660	COG3706	GGDEF domain
N175_08660	COG0745	RESPONSE REGULATOR receiver
N175_08670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
N175_08670	COG1648	precorrin-2 dehydrogenase activity
N175_08675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N175_08680	COG4597	amino acid ABC transporter
N175_08685	COG0765	amino acid transport
N175_08690	COG1126	abc transporter atp-binding protein
N175_08695	COG0670	Belongs to the BI1 family
N175_08700	COG2920	part of a sulfur-relay system
N175_08705	COG1254	Belongs to the acylphosphatase family
N175_08710	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
N175_08720	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
N175_08750	COG0602	queuosine metabolic process
N175_08755	COG0561	phosphatase activity
N175_08775	COG2828	Protein conserved in bacteria
N175_08780	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
N175_08785	COG0372	Belongs to the citrate synthase family
N175_08790	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
N175_08820	COG0745	RESPONSE REGULATOR receiver
N175_08825	COG5002	protein histidine kinase activity
N175_08830	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
N175_08835	COG1902	pentaerythritol trinitrate reductase activity
N175_08840	COG0583	DNA-binding transcription factor activity
N175_08850	COG1129	ABC transporter
N175_08880	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N175_08890	COG2207	Transcriptional regulator
N175_08900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N175_08900	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N175_08900	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N175_08925	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
N175_08930	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
N175_08935	COG3051	citrate lyase alpha subunit
N175_08940	COG2301	Belongs to the HpcH HpaI aldolase family
N175_08945	COG3052	prosthetic group binding
N175_08950	COG4565	transcriptional regulatory protein
N175_08960	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
N175_08965	COG5016	pyruvate
N175_08965	COG0511	ligase activity, forming carbon-carbon bonds
N175_08980	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
N175_09000	COG0840	transmembrane signaling receptor activity
N175_09010	COG0840	transmembrane signaling receptor activity
N175_09020	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N175_09025	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N175_09030	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N175_09060	COG0840	transmembrane signaling receptor activity
N175_09065	COG0019	diaminopimelate decarboxylase activity
N175_09085	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N175_09100	COG4181	ATPase activity
N175_09105	COG0534	Mate efflux family protein
N175_09110	COG0702	epimerase
N175_09120	COG2814	Major facilitator Superfamily
N175_09125	COG1187	pseudouridine synthase activity
N175_09130	COG1061	Type III restriction enzyme res subunit
N175_09145	COG2205	protein histidine kinase activity
N175_09190	COG0564	pseudouridine synthase activity
N175_09195	COG0733	neurotransmitter:sodium symporter activity
N175_09205	COG0626	cystathionine gamma-synthase activity
N175_09210	COG0519	Catalyzes the synthesis of GMP from XMP
N175_09225	COG1842	Phage shock protein A
N175_09230	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
N175_09240	COG4168	peptide transport system, permease
N175_09245	COG4171	peptide transport system, permease
N175_09255	COG4172	Belongs to the ABC transporter superfamily
N175_09270	COG1227	inorganic diphosphatase activity
N175_09280	COG0243	molybdopterin cofactor binding
N175_09285	COG3005	denitrification pathway
N175_09290	COG4459	periplasmic nitrate reductase
N175_09295	COG2116	formate transmembrane transporter activity
N175_09320	COG1434	Gram-negative-bacterium-type cell wall biogenesis
N175_09325	COG1435	thymidine kinase activity
N175_09330	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
N175_09335	COG1801	Protein of unknown function DUF72
N175_09345	COG4106	trans-aconitate 2-methyltransferase activity
N175_09355	COG0189	ligase activity
N175_09355	COG4067	protein conserved in archaea
N175_09370	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
N175_09375	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
N175_09385	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N175_09390	COG1434	Gram-negative-bacterium-type cell wall biogenesis
N175_09395	COG0745	RESPONSE REGULATOR receiver
N175_09410	COG1609	Transcriptional regulator
N175_09415	COG3070	regulator of competence-specific genes
N175_09435	COG0297	glycogen (starch) synthase activity
N175_09440	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
N175_09445	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N175_09455	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
N175_09460	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
N175_09465	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
N175_09470	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N175_09475	COG0542	response to heat
N175_09480	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
N175_09485	COG1278	Cold shock
N175_09495	COG1187	pseudouridine synthase activity
N175_09500	COG0140	phosphoribosyl-ATP diphosphatase activity
N175_09500	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
N175_09505	COG0107	imidazoleglycerol-phosphate synthase activity
N175_09510	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
N175_09515	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
N175_09520	COG0131	Imidazoleglycerol-phosphate dehydratase
N175_09520	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
N175_09525	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N175_09530	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N175_09540	COG1757	Na H antiporter
N175_09550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N175_09560	COG0482	sulfurtransferase activity
N175_09565	COG2915	High frequency lysogenization protein hflD homolog
N175_09570	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N175_09575	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
N175_09585	COG4191	Histidine kinase
N175_09585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N175_09600	COG3070	regulator of competence-specific genes
N175_09610	COG2431	L-lysine efflux transmembrane transporter activity
N175_09620	COG0076	glutamate decarboxylase activity
N175_09625	COG1737	Transcriptional regulator
N175_09635	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N175_09655	COG0281	malic enzyme
N175_09665	COG2949	membrane
N175_09680	COG3706	GGDEF domain
N175_09680	COG0745	RESPONSE REGULATOR receiver
N175_09685	COG0492	ferredoxin-NADP+ reductase activity
N175_09690	COG4988	ABC transporter
N175_09695	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
N175_09710	COG1595	DNA-templated transcription, initiation
N175_09725	COG1187	pseudouridine synthase activity
N175_09730	COG0009	L-threonylcarbamoyladenylate synthase
N175_09735	COG0613	PHP domain protein
N175_09745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N175_09750	COG0512	Glutamine amidotransferase of anthranilate synthase
N175_09755	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N175_09760	COG0135	phosphoribosylanthranilate isomerase activity
N175_09760	COG0134	indole-3-glycerol-phosphate synthase activity
N175_09765	COG0133	tryptophan synthase activity
N175_09795	COG1607	acyl-coa hydrolase
N175_09800	COG2350	Protein conserved in bacteria
N175_09810	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
N175_09815	COG0583	DNA-binding transcription factor activity
N175_09830	COG2203	Gaf domain
N175_09830	COG2199	diguanylate cyclase activity
N175_09830	COG2200	EAL domain
N175_09840	COG1032	radical SAM domain protein
N175_09850	COG2268	Band 7 protein
N175_09860	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
N175_09875	COG0300	oxidoreductase activity
N175_09885	COG0501	Belongs to the peptidase M48B family
N175_09895	COG1674	ftsk spoiiie
N175_09900	COG1522	sequence-specific DNA binding
N175_09905	COG0686	Belongs to the AlaDH PNT family
N175_09915	COG0583	DNA-binding transcription factor activity
N175_09930	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
N175_09935	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
N175_09945	COG0539	negative regulation of cytoplasmic translation
N175_09950	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
N175_09955	COG1555	photosystem II stabilization
N175_09960	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N175_09965	COG0776	regulation of translation
N175_09970	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
N175_09985	COG0544	peptidyl-prolyl cis-trans isomerase activity
N175_10005	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
N175_10010	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
N175_10015	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
N175_10020	COG1653	transport
N175_10025	COG2205	protein histidine kinase activity
N175_10030	COG0745	RESPONSE REGULATOR receiver
N175_10035	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
N175_10040	COG1760	l-serine dehydratase
N175_10050	COG0513	Belongs to the DEAD box helicase family
N175_10060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N175_10075	COG4628	conserved protein (DUF2132)
N175_10105	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
N175_10110	COG0583	DNA-binding transcription factor activity
N175_10115	COG2951	lytic endotransglycosylase activity
N175_10120	COG3100	YcgL domain-containing protein
N175_10130	COG2894	cell division
N175_10140	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
N175_10145	COG0318	PFAM AMP-dependent synthetase and ligase
N175_10150	COG0596	Alpha beta hydrolase
N175_10165	COG1214	PFAM Peptidase M22, glycoprotease
N175_10170	COG1199	ATP-dependent helicase activity
N175_10180	COG0788	formyltetrahydrofolate deformylase activity
N175_10185	COG0446	pyridine nucleotide-disulphide oxidoreductase
N175_10185	COG1902	pentaerythritol trinitrate reductase activity
N175_10190	COG0616	signal peptide processing
N175_10195	COG0252	asparaginase activity
N175_10200	COG3139	Protein of unknown function (DUF1315)
N175_10210	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N175_10225	COG2226	methyltransferase
N175_10255	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
N175_10265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N175_10270	COG2832	Protein of unknown function (DUF454)
N175_10280	COG0745	RESPONSE REGULATOR receiver
N175_10285	COG0583	DNA-binding transcription factor activity
N175_10290	COG0778	Nitroreductase
N175_10295	COG1250	3-hydroxyacyl-CoA dehydrogenase
N175_10295	COG1024	Enoyl-CoA hydratase
N175_10300	COG0183	Belongs to the thiolase family
N175_10310	COG1595	DNA-templated transcription, initiation
N175_10320	COG2067	long-chain fatty acid transport protein
N175_10325	COG2067	long-chain fatty acid transport protein
N175_10330	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
N175_10335	COG2982	Protein involved in outer membrane biogenesis
N175_10340	COG0572	uridine kinase
N175_10345	COG0489	protein tyrosine kinase activity
N175_10350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N175_10350	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N175_10360	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
N175_10375	COG4109	DRTGG domain
N175_10380	COG2199	diguanylate cyclase activity
N175_10385	COG0314	molybdopterin synthase activity
N175_10390	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
N175_10400	COG0521	Mo-molybdopterin cofactor biosynthetic process
N175_10405	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N175_10410	COG0391	Required for morphogenesis under gluconeogenic growth conditions
N175_10415	COG2198	Histidine kinase
N175_10425	COG0556	nucleotide-excision repair
N175_10445	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N175_10450	COG1028	Short-chain dehydrogenase reductase Sdr
N175_10455	COG1169	isochorismate synthase
N175_10460	COG1021	2,3-dihydroxybenzoate-AMP ligase
N175_10465	COG1535	isochorismatase
N175_10465	COG3433	isochorismatase activity
N175_10485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N175_10495	COG2382	esterase
N175_10505	COG4774	siderophore transport
N175_10505	COG1629	transport
N175_10515	COG4657	Part of a membrane complex involved in electron transport
N175_10520	COG2878	Part of a membrane complex involved in electron transport
N175_10525	COG4656	Part of a membrane complex involved in electron transport
N175_10530	COG4658	electron transport chain
N175_10545	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N175_10550	COG0346	lactoylglutathione lyase activity
N175_10560	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N175_10565	COG2056	Na+-H+ antiporter family
N175_10570	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
N175_10575	COG1286	toxin biosynthetic process
N175_10580	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
N175_10585	COG0285	dihydrofolate synthase activity
N175_10610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N175_10615	COG2190	(PTS) system
N175_10615	COG1263	PTS System
N175_10615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N175_10620	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
N175_10625	COG1940	carbohydrate kinase activity
N175_10625	COG1846	Transcriptional regulator
N175_10630	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N175_10630	COG4651	solute:proton antiporter activity
N175_10640	COG0367	asparagine synthase
N175_10650	COG3104	oligopeptide transport
N175_10655	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
N175_10665	COG0326	Molecular chaperone. Has ATPase activity
N175_10675	COG3710	Transcriptional regulator
N175_10690	COG0622	Phosphoesterase
N175_10695	COG1090	epimerase
N175_10700	COG3118	belongs to the thioredoxin family
N175_10710	COG0330	HflC and HflK could
N175_10720	COG0789	Transcriptional regulator
N175_10745	COG3115	cell septum assembly
N175_10750	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
N175_10755	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N175_10760	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N175_10765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N175_10770	COG2190	(PTS) system
N175_10775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N175_10780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N175_10785	COG1702	phosphate starvation-inducible protein PhoH
N175_10795	COG4535	Mg2 and Co2 transporter CorC
N175_10800	COG0815	Transfers the fatty acyl group on membrane lipoproteins
N175_10805	COG2888	peptidyl-tyrosine sulfation
N175_10810	COG0495	leucyl-tRNA aminoacylation
N175_10815	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
N175_10820	COG1466	dna polymerase III delta subunit
N175_10825	COG0799	negative regulation of ribosome biogenesis
N175_10830	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
N175_10835	COG0768	penicillin binding
N175_10840	COG0772	Belongs to the SEDS family
N175_10845	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
N175_10850	COG1686	Belongs to the peptidase S11 family
N175_10855	COG2921	Belongs to the UPF0250 family
N175_10860	COG0321	lipoyl(octanoyl) transferase activity
N175_10875	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N175_10895	COG1596	polysaccharide export
N175_10900	COG0489	protein tyrosine kinase activity
N175_10925	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
N175_10935	COG1045	serine acetyltransferase
N175_10975	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
N175_10980	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
N175_10990	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N175_10995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N175_11000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N175_11040	COG2205	protein histidine kinase activity
N175_11045	COG0745	RESPONSE REGULATOR receiver
N175_11050	COG0366	Alpha amylase catalytic
N175_11055	COG1263	PTS System
N175_11055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N175_11070	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
N175_11075	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N175_11080	COG2011	ABC-type metal ion transport system permease component
N175_11085	COG1464	Belongs to the NlpA lipoprotein family
N175_11090	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
N175_11110	COG3706	GGDEF domain
N175_11120	COG1611	Belongs to the LOG family
N175_11125	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N175_11135	COG2363	Small membrane protein
N175_11140	COG0583	DNA-binding transcription factor activity
N175_11145	COG0301	tRNA thio-modification
N175_11145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N175_11155	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
N175_11170	COG0142	geranyltranstransferase activity
N175_11175	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N175_11180	COG0564	pseudouridine synthase activity
N175_11185	COG3098	single-species biofilm formation
N175_11220	COG0257	Belongs to the bacterial ribosomal protein bL36 family
N175_11230	COG1720	tRNA m6t6A37 methyltransferase activity
N175_11235	COG0442	prolyl-tRNA aminoacylation
N175_11240	COG2979	Protein of unknown function (DUF533)
N175_11260	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N175_11260	COG0047	phosphoribosylformylglycinamidine synthase activity
N175_11265	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
N175_11275	COG0590	tRNA wobble adenosine to inosine editing
N175_11280	COG0583	DNA-binding transcription factor activity
N175_11290	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
N175_11295	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
N175_11325	COG0484	heat shock protein binding
N175_11330	COG0443	Heat shock 70 kDa protein
N175_11335	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
N175_11340	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N175_11355	COG0497	DNA recombination
N175_11360	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N175_11365	COG2914	Belongs to the UPF0125 (RnfH) family
N175_11370	COG2867	negative regulation of translational initiation
N175_11380	COG0582	viral genome integration into host DNA
N175_11385	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
N175_11405	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
N175_11410	COG1715	Restriction endonuclease
N175_11425	COG2003	Belongs to the UPF0758 family
N175_11550	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N175_11555	COG4136	ATPase activity
N175_11560	COG4135	transport system, permease component
N175_11565	COG4134	Bacterial extracellular solute-binding protein
N175_11575	COG3313	Fe-S protein
N175_11585	COG0737	Belongs to the 5'-nucleotidase family
N175_11605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N175_11610	COG1115	amino acid carrier protein
N175_11615	COG1584	GPR1 FUN34 yaaH family protein
N175_11625	COG0351	phosphomethylpyrimidine kinase
N175_11630	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N175_11630	COG0519	Catalyzes the synthesis of GMP from XMP
N175_11635	COG0517	IMP dehydrogenase activity
N175_11635	COG0516	GMP reductase activity
N175_11650	COG1160	GTP binding
N175_11655	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N175_11660	COG2976	Protein conserved in bacteria
N175_11665	COG0124	histidyl-tRNA synthetase
N175_11670	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
N175_11675	COG1426	Protein conserved in bacteria
N175_11690	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N175_11695	COG2975	iron-sulfur cluster assembly
N175_11700	COG0633	Ferredoxin
N175_11705	COG0443	Heat shock 70 kDa protein
N175_11715	COG0316	Belongs to the HesB IscA family
N175_11720	COG0822	iron-sulfur transferase activity
N175_11730	COG1959	2 iron, 2 sulfur cluster binding
N175_11735	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
N175_11740	COG0483	inositol monophosphate 1-phosphatase activity
N175_11745	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N175_11750	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N175_11755	COG1862	Preprotein translocase
N175_11765	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
N175_11770	COG0517	IMP dehydrogenase activity
N175_11785	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
N175_11790	COG0583	DNA-binding transcription factor activity
N175_11795	COG0450	alkyl hydroperoxide reductase
N175_11800	COG3142	Participates in the control of copper homeostasis
N175_11805	COG0704	Plays a role in the regulation of phosphate uptake
N175_11810	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N175_11815	COG0581	inorganic phosphate transmembrane transporter activity
N175_11825	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
N175_11830	COG0248	Ppx GppA phosphatase
N175_11840	COG5002	protein histidine kinase activity
N175_11845	COG0745	RESPONSE REGULATOR receiver
N175_11860	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
N175_11910	COG0542	response to heat
N175_11920	COG0564	pseudouridine synthase activity
N175_11925	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N175_11935	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
N175_11940	COG1605	Chorismate mutase
N175_11940	COG0077	Prephenate dehydratase
N175_11945	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
N175_11950	COG5001	Diguanylate cyclase
N175_11955	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
N175_11970	COG0488	(ABC) transporter
N175_11980	COG1605	Chorismate mutase
N175_11980	COG0287	Prephenate dehydrogenase
N175_11985	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N175_11990	COG3275	phosphorelay sensor kinase activity
N175_12000	COG3279	Response regulator of the LytR AlgR family
N175_12005	COG1472	Belongs to the glycosyl hydrolase 3 family
N175_12010	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
N175_12015	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
N175_12030	COG1966	Carbon starvation protein
N175_12040	COG1047	Peptidyl-prolyl cis-trans
N175_12045	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
N175_12055	COG0196	riboflavin kinase activity
N175_12060	COG0728	peptidoglycan biosynthetic process
N175_12070	COG0640	Transcriptional regulator
N175_12075	COG0583	DNA-binding transcription factor activity
N175_12080	COG1283	sodium-dependent phosphate transmembrane transporter activity
N175_12090	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
N175_12125	COG2433	Pfam Transposase IS66
N175_12185	COG2433	Pfam Transposase IS66
N175_12250	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
N175_12260	COG0730	response to heat
N175_12270	COG0494	nUDIX hydrolase
N175_12275	COG3066	DNA modification
N175_12280	COG0667	Aldo Keto reductase
N175_12290	COG2204	response regulator
N175_12295	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
N175_12300	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
N175_12315	COG0513	Belongs to the DEAD box helicase family
N175_12345	COG3153	acetyltransferase
N175_12375	COG1846	Transcriptional regulator
N175_12395	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
N175_12405	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
N175_12410	COG0195	Participates in both transcription termination and antitermination
N175_12415	COG0779	Required for maturation of 30S ribosomal subunits
N175_12430	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N175_12435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N175_12440	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N175_12445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N175_12455	COG1534	Rna-binding protein
N175_12460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N175_12470	COG2027	D-alanyl-D-alanine carboxypeptidase
N175_12475	COG2239	Acts as a magnesium transporter
N175_12485	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N175_12490	COG0739	heme binding
N175_12510	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
N175_12520	COG0628	permease
N175_12545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N175_12550	COG0444	Belongs to the ABC transporter superfamily
N175_12555	COG4608	Belongs to the ABC transporter superfamily
N175_12565	COG2971	BadF BadG BcrA BcrD
N175_12580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N175_12595	COG1840	ABC-type Fe3 transport system, periplasmic component
N175_12600	COG0004	ammonium transporteR
N175_12615	COG3835	regulator
N175_12620	COG2610	gluconate transmembrane transporter activity
N175_12625	COG1929	Belongs to the glycerate kinase type-1 family
N175_12630	COG1049	propionate catabolic process, 2-methylcitrate cycle
N175_12635	COG1752	Esterase of the alpha-beta hydrolase superfamily
N175_12640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N175_12645	COG1643	Atp-dependent helicase
N175_12650	COG1489	DNA binding
N175_12655	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
N175_12660	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N175_12670	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N175_12680	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
N175_12690	COG0842	Transport permease protein
N175_12695	COG1131	(ABC) transporter
N175_12700	COG0659	secondary active sulfate transmembrane transporter activity
N175_12705	COG0288	reversible hydration of carbon dioxide
N175_12720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N175_12725	COG0508	dehydrogenase complex catalyzes the overall conversion of
N175_12730	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
N175_12735	COG2186	Transcriptional regulator
N175_12740	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
N175_12745	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N175_12750	COG4974	Belongs to the 'phage' integrase family
N175_12755	COG0716	FMN binding
N175_12765	COG0157	Belongs to the NadC ModD family
N175_12785	COG1459	type II secretion system
N175_12795	COG0237	dephospho-CoA kinase activity
N175_12800	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
N175_12805	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
N175_12810	COG0335	large ribosomal subunit rRNA binding
N175_12830	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N175_12835	COG4137	Cytochrome C assembly protein
N175_12840	COG4536	flavin adenine dinucleotide binding
N175_12855	COG0612	Peptidase, M16
N175_12860	COG1238	metal cluster binding
N175_12865	COG1063	alcohol dehydrogenase
N175_12870	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
N175_12875	COG5016	pyruvate
N175_12875	COG0511	ligase activity, forming carbon-carbon bonds
N175_12880	COG3630	sodium ion export across plasma membrane
N175_12930	COG0527	aspartate kinase activity
N175_12935	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N175_12940	COG2137	regulation of response to DNA damage stimulus
N175_12945	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
N175_12950	COG1546	Belongs to the CinA family
N175_12955	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
N175_12960	COG4208	sulfate ABC transporter
N175_12970	COG4150	thiosulfate binding
N175_12980	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
N175_12985	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N175_12990	COG4942	peptidase
N175_12990	COG1388	LysM domain
N175_12995	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
N175_13000	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
N175_13005	COG0585	pseudouridine synthase activity
N175_13010	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
N175_13015	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
N175_13020	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
N175_13025	COG1968	undecaprenyl-diphosphatase activity
N175_13030	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N175_13035	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
N175_13060	COG1610	YqeY-like protein
N175_13065	COG0358	DNA primase activity
N175_13070	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N175_13085	COG3550	peptidyl-serine autophosphorylation
N175_13105	COG0210	DNA helicase
N175_13135	COG2801	Transposase and inactivated derivatives
N175_13210	COG2801	Transposase and inactivated derivatives
N175_13275	COG4584	PFAM Integrase catalytic
N175_13280	COG1484	DNA-dependent DNA replication
N175_13430	COG3501	Rhs element vgr protein
N175_13450	COG4932	domain protein
N175_13450	COG5492	domain, Protein
N175_13460	COG1349	DNA-binding transcription factor activity
N175_13480	COG3706	GGDEF domain
N175_13500	COG0668	transmembrane transport
N175_13505	COG0191	fructose-bisphosphate aldolase activity
N175_13510	COG0126	phosphoglycerate kinase activity
N175_13515	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N175_13520	COG4771	TonB-dependent receptor
N175_13525	COG0583	DNA-binding transcription factor activity
N175_13530	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
N175_13535	COG3091	SprT-like family
N175_13540	COG2356	endonuclease I
N175_13545	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N175_13555	COG1678	Uncharacterized ACR, COG1678
N175_13560	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
N175_13575	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
N175_13580	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
N175_13585	COG0762	integral membrane protein
N175_13590	COG1872	DUF167
N175_13605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N175_13610	COG2066	Belongs to the glutaminase family
N175_13615	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N175_13630	COG0741	lytic transglycosylase activity
N175_13680	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
N175_13685	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
N175_13695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N175_13700	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
N175_13710	COG2967	ApaG domain
N175_13725	COG3610	response to peptide
N175_13730	COG2966	Psort location CytoplasmicMembrane, score
N175_13735	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N175_13740	COG0211	Belongs to the bacterial ribosomal protein bL27 family
N175_13750	COG0142	geranyltranstransferase activity
N175_13755	COG0531	amino acid
N175_13785	COG0589	response to stress
N175_13905	COG2235	arginine
N175_13910	COG0312	modulator of DNA gyrase
N175_13915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N175_13920	COG3164	Protein of unknown function
N175_13925	COG1530	ribonuclease E activity
N175_13935	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
N175_13940	COG1792	Involved in formation and maintenance of cell shape
N175_13945	COG1077	Cell shape determining protein MreB Mrl
N175_13990	COG1459	type II secretion system
N175_13995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N175_14005	COG3267	Type II secretory pathway component ExeA
N175_14005	COG3409	Peptidoglycan-binding domain 1 protein
N175_14030	COG2199	diguanylate cyclase activity
N175_14030	COG2200	EAL domain
N175_14035	COG0629	single-stranded DNA binding
N175_14050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N175_14060	COG2239	Acts as a magnesium transporter
N175_14075	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
N175_14080	COG0527	aspartate kinase activity
N175_14085	COG0646	methionine synthase
N175_14085	COG1410	methionine synthase
N175_14120	COG0175	sulfate reduction
N175_14125	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N175_14130	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
N175_14150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N175_14155	COG0735	belongs to the Fur family
N175_14165	COG0166	Belongs to the GPI family
N175_14170	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N175_14175	COG0305	Participates in initiation and elongation during chromosome replication
N175_14185	COG0359	binds to the 23S rRNA
N175_14195	COG2965	DNA replication, synthesis of RNA primer
N175_14200	COG0360	Binds together with S18 to 16S ribosomal RNA
N175_14205	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N175_14210	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N175_14215	COG0049	tRNA binding
N175_14230	COG2923	Belongs to the DsrF TusC family
N175_14235	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
N175_14240	COG2964	Protein conserved in bacteria
N175_14245	COG0545	Peptidyl-prolyl cis-trans isomerase
N175_14260	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
N175_14265	COG0330	HflC and HflK could
N175_14270	COG0330	HflC and HflK could
N175_14275	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N175_14280	COG1923	regulation of RNA biosynthetic process
N175_14285	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
N175_14290	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
N175_14300	COG0802	atpase or kinase
N175_14320	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
N175_14325	COG1162	GTPase activity
N175_14335	COG0490	domain, Protein
N175_14335	COG0471	metal ion transport
N175_14350	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
N175_14355	COG4942	peptidase
N175_14375	COG2816	NAD+ diphosphatase activity
N175_14380	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
N175_14385	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N175_14390	COG0085	RNA polymerase activity
N175_14395	COG0222	ribosome binding
N175_14400	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
N175_14405	COG0081	regulation of translation
N175_14415	COG0250	Participates in transcription elongation, termination and antitermination
N175_14420	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N175_14425	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N175_14450	COG1072	(Pantothenic acid kinase))
N175_14455	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
N175_14455	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
N175_14460	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N175_14470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N175_14555	COG2433	Pfam Transposase IS66
N175_14580	COG0724	RNA recognition motif
N175_14640	COG2801	Transposase and inactivated derivatives
N175_14645	COG2963	transposase activity
N175_14705	COG0023	Translation Initiation Factor
N175_14720	COG1181	Belongs to the D-alanine--D-alanine ligase family
N175_14730	COG1042	CoA-binding domain protein
N175_14730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N175_14730	COG0045	succinate-CoA ligase (ADP-forming) activity
N175_14735	COG0583	DNA-binding transcription factor activity
N175_14750	COG3140	Belongs to the UPF0181 family
N175_14765	COG0745	RESPONSE REGULATOR receiver
N175_14775	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
N175_14780	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
N175_14795	COG3706	GGDEF domain
N175_14800	COG1278	Cold shock
N175_14810	COG0840	transmembrane signaling receptor activity
N175_14825	COG2501	S4 domain
N175_14830	COG0625	glutathione transferase activity
N175_14845	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N175_14850	COG0488	(ABC) transporter
N175_14865	COG2050	protein possibly involved in aromatic compounds catabolism
N175_14875	COG2824	Alkylphosphonate utilization operon protein PhnA
N175_14885	COG0861	Integral membrane protein TerC family
N175_14890	COG0737	Belongs to the 5'-nucleotidase family
N175_14895	COG3593	DNA synthesis involved in DNA repair
N175_14905	COG0583	DNA-binding transcription factor activity
N175_14910	COG2116	formate transmembrane transporter activity
N175_14930	COG2188	Transcriptional regulator
N175_14935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N175_14940	COG1011	Hydrolase
N175_14945	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
N175_14950	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
N175_14955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N175_14965	COG2759	Belongs to the formate--tetrahydrofolate ligase family
N175_14970	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N175_14970	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N175_14975	COG0302	gtp cyclohydrolase
N175_14980	COG0303	'Molybdopterin
N175_14985	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
N175_14990	COG2897	thiosulfate sulfurtransferase activity
N175_15010	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
N175_15025	COG0545	Peptidyl-prolyl cis-trans isomerase
N175_15030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N175_15035	COG0840	transmembrane signaling receptor activity
N175_15040	COG2353	YceI-like domain
N175_15045	COG3038	cytochrome b561
N175_15055	COG4251	negative regulation of phosphorylation
N175_15055	COG2203	Gaf domain
N175_15055	COG5001	Diguanylate cyclase
N175_15055	COG3706	GGDEF domain
N175_15060	COG4172	Belongs to the ABC transporter superfamily
N175_15065	COG4239	(ABC) transporter, permease
N175_15070	COG4174	ABC transporter (Permease)
N175_15075	COG4166	transmembrane transport
N175_15090	COG0189	ligase activity
N175_15090	COG4067	protein conserved in archaea
N175_15100	COG0602	queuosine metabolic process
N175_15105	COG1328	CTP reductase activity
N175_15110	COG3706	GGDEF domain
N175_15135	COG0640	Transcriptional regulator
N175_15150	COG5001	Diguanylate cyclase
N175_15150	COG3300	MHYT domain
N175_15155	COG4191	Histidine kinase
N175_15160	COG3852	Histidine kinase
N175_15170	COG3437	response regulator, receiver
N175_15185	COG5001	Diguanylate cyclase
N175_15185	COG3706	GGDEF domain
N175_15185	COG2203	Gaf domain
N175_15185	COG4251	negative regulation of phosphorylation
N175_15195	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
N175_15200	COG4149	molybdate abc transporter
N175_15205	COG0725	ABC transporter, periplasmic molybdate-binding protein
N175_15210	COG1492	cobalamin metabolic process
N175_15215	COG3111	PFAM Bacterial OB fold (BOF) protein
N175_15225	COG3447	MASE1 domain protein
N175_15225	COG5001	Diguanylate cyclase
N175_15225	COG5002	protein histidine kinase activity
N175_15230	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
N175_15240	COG2207	Transcriptional regulator
N175_15245	COG1979	alcohol dehydrogenase
N175_15260	COG1840	ABC-type Fe3 transport system, periplasmic component
N175_15265	COG2271	Major facilitator Superfamily
N175_15270	COG0469	pyruvate kinase activity
N175_15275	COG2198	Histidine kinase
N175_15275	COG2205	protein histidine kinase activity
N175_15275	COG0784	Response regulator, receiver
N175_15280	COG1879	ABC-type sugar transport system periplasmic component
N175_15285	COG1803	Methylglyoxal synthase
N175_15290	COG0210	DNA helicase
N175_15295	COG1289	transmembrane transporter activity
N175_15325	COG5002	protein histidine kinase activity
N175_15325	COG0784	Response regulator, receiver
N175_15340	COG2827	Endonuclease containing a URI domain
N175_15365	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N175_15370	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N175_15375	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
N175_15380	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
N175_15385	COG0247	lactate metabolic process
N175_15390	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N175_15395	COG3118	belongs to the thioredoxin family
N175_15415	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N175_15430	COG2146	nitrite reductase [NAD(P)H] activity
N175_15435	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N175_15465	COG4176	ABC-type proline glycine betaine transport system permease component
N175_15470	COG0517	IMP dehydrogenase activity
N175_15470	COG4175	Glycine betaine
N175_15485	COG2425	protein containing a von Willebrand factor type A (vWA) domain
N175_15500	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
N175_15510	COG0513	Belongs to the DEAD box helicase family
N175_15520	COG0814	amino acid
N175_15530	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N175_15535	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
N175_15545	COG1984	allophanate hydrolase subunit 2
N175_15555	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
N175_15560	COG4181	ATPase activity
N175_15570	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
N175_15575	COG5001	Diguanylate cyclase
N175_15575	COG1716	ATPase activity
N175_15585	COG0484	heat shock protein binding
N175_15600	COG0784	Response regulator, receiver
N175_15600	COG3437	response regulator, receiver
N175_15625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N175_15630	COG5001	Diguanylate cyclase
N175_15630	COG3300	MHYT domain
N175_15650	COG0010	Belongs to the arginase family
N175_15655	COG1166	arginine decarboxylase activity
N175_15670	COG4176	ABC-type proline glycine betaine transport system permease component
N175_15675	COG2113	Glycine betaine
N175_15695	COG2239	Acts as a magnesium transporter
N175_15700	COG0527	aspartate kinase activity
N175_15705	COG0662	Cupin 2, conserved barrel domain protein
N175_15710	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N175_15715	COG0456	acetyltransferase
N175_15725	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
N175_15770	COG0366	Alpha amylase catalytic
N175_15790	COG0714	Associated with various cellular activities
N175_15810	COG2304	oxidoreductase activity
N175_15825	COG3706	GGDEF domain
N175_15835	COG1403	HNH endonuclease
N175_15840	COG3530	Putative quorum-sensing-regulated virulence factor
N175_15845	COG1368	sulfuric ester hydrolase activity
N175_15855	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
N175_15860	COG1063	alcohol dehydrogenase
N175_15865	COG0156	8-amino-7-oxononanoate synthase activity
N175_15875	COG0346	lactoylglutathione lyase activity
N175_15890	COG2197	response regulator
N175_15900	COG2271	Major facilitator Superfamily
N175_15915	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
N175_15935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N175_15940	COG0640	Transcriptional regulator
N175_15945	COG0798	PFAM Bile acid sodium symporter
N175_15960	COG0659	secondary active sulfate transmembrane transporter activity
N175_15965	COG0589	response to stress
N175_15980	COG0516	GMP reductase activity
N175_15985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N175_16015	COG1278	Cold shock
N175_16020	COG4681	YaeQ
N175_16030	COG1017	nitric oxide dioxygenase activity
N175_16030	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N175_16035	COG3604	Transcriptional regulator
N175_16050	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
N175_16055	COG3217	Mosc domain protein beta barrel domain protein
N175_16055	COG0633	Ferredoxin
N175_16065	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N175_16070	COG2354	Protein conserved in bacteria
N175_16075	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
N175_16100	COG2197	response regulator
N175_16130	COG3706	GGDEF domain
N175_16135	COG1349	DNA-binding transcription factor activity
N175_16165	COG1175	transmembrane transport
N175_16175	COG3842	ATPase activity
N175_16185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N175_16190	COG0784	Response regulator, receiver
N175_16190	COG0835	chemotaxis
N175_16195	COG2315	Protein conserved in bacteria
N175_16200	COG3706	GGDEF domain
N175_16235	COG5001	Diguanylate cyclase
N175_16245	COG1741	Belongs to the pirin family
N175_16255	COG3123	guanosine phosphorylase activity
N175_16265	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N175_16270	COG1126	abc transporter atp-binding protein
N175_16275	COG0765	amino acid transport
N175_16280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N175_16285	COG0765	amino acid transport
N175_16290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N175_16310	COG0179	Fumarylacetoacetate (FAA) hydrolase
N175_16320	COG0697	spore germination
N175_16340	COG2814	Major facilitator Superfamily
N175_16345	COG0583	DNA-binding transcription factor activity
N175_16350	COG5001	Diguanylate cyclase
N175_16355	COG0739	heme binding
N175_16365	COG0659	secondary active sulfate transmembrane transporter activity
N175_16385	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N175_16390	COG0581	inorganic phosphate transmembrane transporter activity
N175_16395	COG0573	inorganic phosphate transmembrane transporter activity
N175_16400	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N175_16410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N175_16415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N175_16440	COG3047	cAMP biosynthetic process
N175_16450	COG3397	chitin binding
N175_16455	COG2271	Major facilitator Superfamily
N175_16460	COG0584	glycerophosphoryl diester phosphodiesterase
N175_16470	COG3527	Alpha-acetolactate decarboxylase
N175_16495	COG0583	DNA-binding transcription factor activity
N175_16500	COG1620	l-lactate permease
N175_16505	COG1304	FMN binding
N175_16520	COG1881	PFAM PEBP family protein
N175_16525	COG3122	Protein conserved in bacteria
N175_16535	COG3568	Endonuclease Exonuclease Phosphatase
N175_16550	COG0840	transmembrane signaling receptor activity
N175_16560	COG0840	transmembrane signaling receptor activity
N175_16565	COG1609	Transcriptional regulator
N175_16570	COG1472	Belongs to the glycosyl hydrolase 3 family
N175_16575	COG3842	ATPase activity
N175_16580	COG0395	ABC-type sugar transport system, permease component
N175_16595	COG1609	Transcriptional regulator
N175_16600	COG4580	involved in the transport of maltose and maltodextrins
N175_16620	COG2211	Major facilitator Superfamily
N175_16630	COG1067	ATP-dependent peptidase activity
N175_16640	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
N175_16645	COG0363	glucosamine-6-phosphate deaminase activity
N175_16660	COG0583	DNA-binding transcription factor activity
N175_16675	COG1609	Transcriptional regulator
N175_16680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N175_16685	COG1879	ABC-type sugar transport system periplasmic component
N175_16690	COG1172	Belongs to the binding-protein-dependent transport system permease family
N175_16695	COG1129	ABC transporter
N175_16700	COG1869	D-ribose catabolic process
N175_16720	COG3501	Rhs element vgr protein
N175_16735	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
N175_16740	COG1640	4-alpha-glucanotransferase
N175_16745	COG0058	SHG alpha-glucan phosphorylase activity
N175_16750	COG2909	trisaccharide binding
N175_16775	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N175_16805	COG0840	transmembrane signaling receptor activity
N175_16840	COG1262	PFAM Formylglycine-generating sulfatase enzyme
N175_16850	COG0259	pyridoxamine-phosphate oxidase activity
N175_16880	COG3706	GGDEF domain
N175_16880	COG0745	RESPONSE REGULATOR receiver
N175_16900	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
N175_16905	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
N175_16910	COG0840	transmembrane signaling receptor activity
N175_16915	COG0835	chemotaxis
N175_16920	COG0835	chemotaxis
N175_16925	COG2198	Histidine kinase
N175_16925	COG0643	Histidine kinase
N175_16930	COG0745	RESPONSE REGULATOR receiver
N175_16940	COG1444	tRNA N-acetyltransferase activity
N175_16945	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
N175_17000	COG2084	Dehydrogenase
N175_17005	COG0814	amino acid
N175_17035	COG0583	DNA-binding transcription factor activity
N175_17040	COG2910	NAD(P)H-binding
N175_17050	COG3304	Inner membrane component domain
N175_17065	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N175_17070	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
N175_17100	COG0363	glucosamine-6-phosphate deaminase activity
N175_17110	COG0739	heme binding
N175_17120	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
N175_17120	COG2213	PTS system mannitol-specific
N175_17125	COG0246	Mannitol dehydrogenase
N175_17130	COG3722	fumarate hydratase activity
N175_17140	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
N175_17145	COG1301	dicarboxylic acid transport
N175_17150	COG2259	Doxx family
N175_17180	COG1846	Transcriptional regulator
N175_17190	COG4943	cyclic-guanylate-specific phosphodiesterase activity
N175_17195	COG3046	protein related to deoxyribodipyrimidine photolyase
N175_17200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N175_17205	COG0842	Transport permease protein
N175_17210	COG1131	(ABC) transporter
N175_17225	COG3842	ATPase activity
N175_17235	COG1176	ABC-type spermidine putrescine transport system, permease component I
N175_17255	COG0513	Belongs to the DEAD box helicase family
N175_17260	COG0251	oxidation-reduction process
N175_17265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N175_17275	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
N175_17280	COG1328	CTP reductase activity
N175_17290	COG2130	NADP-dependent
N175_17295	COG1309	transcriptional regulator
N175_17310	COG0745	RESPONSE REGULATOR receiver
N175_17320	COG0564	pseudouridine synthase activity
N175_17415	COG3501	Rhs element vgr protein
N175_17475	COG0471	metal ion transport
N175_17480	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
N175_17490	COG2188	Transcriptional regulator
N175_17495	COG1131	(ABC) transporter
N175_17505	COG0840	transmembrane signaling receptor activity
N175_17535	COG0671	phosphoesterase, PA-phosphatase related
N175_17540	COG4399	Belongs to the UPF0754 family
N175_17545	COG1132	(ABC) transporter
N175_17565	COG3623	hexulose-6-phosphate isomerase
N175_17570	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
N175_17575	COG0561	phosphatase activity
N175_17645	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
N175_17655	COG1999	signal sequence binding
N175_17670	COG0786	glutamate:sodium symporter activity
N175_17695	COG1566	PFAM secretion protein HlyD family protein
N175_17705	COG3706	GGDEF domain
N175_17720	COG0813	purine-nucleoside phosphorylase activity
N175_17725	COG3272	Protein of unknown function (DUF1722)
N175_17730	COG0789	Transcriptional regulator
N175_17735	COG0415	Belongs to the DNA photolyase family
N175_17740	COG1388	LysM domain
N175_17740	COG1376	ErfK ybiS ycfS ynhG family protein
N175_17750	COG0513	Belongs to the DEAD box helicase family
N175_17820	COG2267	carboxylic ester hydrolase activity
N175_17825	COG2267	carboxylic ester hydrolase activity
N175_17830	COG2267	carboxylic ester hydrolase activity
N175_17835	COG2267	carboxylic ester hydrolase activity
N175_17850	COG0366	Alpha amylase catalytic
N175_17855	COG4989	oxidoreductase activity
N175_17865	COG1136	(ABC) transporter
N175_17865	COG0577	efflux transmembrane transporter activity
N175_17870	COG4591	ABC-type transport system involved in lipoprotein release permease component
N175_17885	COG2972	Histidine kinase
N175_17885	COG0745	RESPONSE REGULATOR receiver
N175_17890	COG3279	Response regulator of the LytR AlgR family
N175_17895	COG5001	Diguanylate cyclase
N175_17895	COG4251	negative regulation of phosphorylation
N175_17895	COG2203	Gaf domain
N175_17895	COG3706	GGDEF domain
N175_17905	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
N175_17915	COG3437	response regulator, receiver
N175_17920	COG2205	protein histidine kinase activity
N175_17920	COG3850	Histidine kinase
N175_17920	COG3437	response regulator, receiver
N175_17920	COG4999	Histidine kinase
N175_17930	COG0531	amino acid
N175_17955	COG5002	protein histidine kinase activity
N175_17955	COG2205	protein histidine kinase activity
N175_17955	COG0784	Response regulator, receiver
N175_17970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N175_17975	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N175_17995	COG0673	inositol 2-dehydrogenase activity
N175_18005	COG0110	maltose O-acetyltransferase activity
N175_18020	COG0583	DNA-binding transcription factor activity
N175_18030	COG0583	DNA-binding transcription factor activity
N175_18035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N175_18040	COG3186	Phenylalanine-4-hydroxylase
N175_18055	COG0840	transmembrane signaling receptor activity
N175_18060	COG0534	Mate efflux family protein
N175_18065	COG2207	Transcriptional regulator
N175_18070	COG0784	Response regulator, receiver
N175_18070	COG3437	response regulator, receiver
N175_18075	COG4191	Histidine kinase
N175_18075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N175_18085	COG2814	Major facilitator Superfamily
N175_18095	COG0443	Heat shock 70 kDa protein
N175_18110	COG3240	lipase activity
N175_18120	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
N175_18125	COG5380	lipid catabolic process
N175_18130	COG3291	Pkd domain containing protein
N175_18130	COG4412	M6 family metalloprotease domain protein
N175_18155	COG4607	ABC-type enterochelin transport system periplasmic component
N175_18160	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N175_18165	COG4605	iron ion homeostasis
N175_18170	COG4604	ABC transporter, ATP-binding protein
N175_18180	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N175_18215	COG2433	Pfam Transposase IS66
N175_18220	COG1162	GTPase activity
N175_18230	COG2226	methyltransferase
N175_18240	COG0861	Integral membrane protein TerC family
N175_18250	COG2249	NAD(P)H dehydrogenase (quinone) activity
N175_18255	COG0656	L-ascorbic acid biosynthetic process
N175_18285	COG1566	PFAM secretion protein HlyD family protein
N175_18310	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N175_18320	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N175_18335	COG0612	Peptidase, M16
N175_18345	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N175_18345	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N175_18345	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
N175_18350	COG1105	Belongs to the carbohydrate kinase PfkB family
N175_18355	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
N175_18355	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N175_18360	COG1609	Transcriptional regulator
N175_18365	COG0420	3'-5' exonuclease activity
N175_18370	COG0419	ATPase involved in DNA repair
N175_18375	COG2205	protein histidine kinase activity
N175_18375	COG0784	Response regulator, receiver
N175_18380	COG0156	8-amino-7-oxononanoate synthase activity
N175_18390	COG0038	chloride channel
N175_18395	COG0523	cobalamin synthesis protein
N175_18400	COG1136	(ABC) transporter
N175_18410	COG0577	efflux transmembrane transporter activity
N175_18410	COG1136	(ABC) transporter
N175_18425	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
N175_18460	COG3730	PTS system glucitol sorbitol-specific
N175_18475	COG1028	Short-chain dehydrogenase reductase Sdr
N175_18480	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
N175_18485	COG1349	DNA-binding transcription factor activity
N175_18490	COG3730	PTS system glucitol sorbitol-specific
N175_18505	COG3842	ATPase activity
N175_18515	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N175_18525	COG2182	Extracellular solute-binding protein
N175_18530	COG1175	transmembrane transport
N175_18535	COG3833	ABC-type maltose transport systems, permease component
N175_18560	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N175_18565	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N175_18575	COG3005	denitrification pathway
N175_18585	COG0243	molybdopterin cofactor binding
N175_18595	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
N175_18600	COG3850	Histidine kinase
N175_18605	COG2197	response regulator
N175_18610	COG3069	C4-dicarboxylate transmembrane transporter activity
N175_18635	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N175_18645	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
N175_18650	COG0513	Belongs to the DEAD box helicase family
N175_18655	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
N175_18680	COG2433	Pfam Transposase IS66
N175_18695	COG1187	pseudouridine synthase activity
N175_18700	COG0500	methyltransferase
N175_18940	COG3040	lipid binding
N175_19245	COG4604	ABC transporter, ATP-binding protein
N175_19250	COG1535	isochorismatase
N175_19250	COG3433	isochorismatase activity
N175_19255	COG1021	2,3-dihydroxybenzoate-AMP ligase
N175_19260	COG1169	isochorismate synthase
N175_19275	COG2433	Pfam Transposase IS66
N175_19295	COG3547	Transposase (IS116 IS110 IS902 family)
N175_19355	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N175_19360	COG4605	iron ion homeostasis
N175_19365	COG4607	ABC-type enterochelin transport system periplasmic component
N175_19370	COG4774	siderophore transport
N175_19380	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
N175_19410	COG0076	glutamate decarboxylase activity
N175_19415	COG1122	ATPase activity
N175_19435	COG2433	Pfam Transposase IS66
N175_19460	COG3657	addiction module killer protein
N175_19485	COG1192	Involved in chromosome partitioning