locus-tag	class	description
A6A12_0002	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6A12_0003	COG0250	Participates in transcription elongation, termination and antitermination
A6A12_0005	COG0081	regulation of translation
A6A12_0006	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6A12_0007	COG0222	ribosome binding
A6A12_0008	COG0085	RNA polymerase activity
A6A12_0009	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6A12_0010	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
A6A12_0011	COG2816	NAD+ diphosphatase activity
A6A12_0015	COG4942	peptidase
A6A12_0017	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A6A12_0020	COG0490	domain, Protein
A6A12_0020	COG0471	metal ion transport
A6A12_0022	COG1162	GTPase activity
A6A12_0023	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A6A12_0026	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6A12_0027	COG0802	atpase or kinase
A6A12_0029	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A6A12_0030	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6A12_0031	COG1923	regulation of RNA biosynthetic process
A6A12_0032	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6A12_0033	COG0330	HflC and HflK could
A6A12_0034	COG0330	HflC and HflK could
A6A12_0035	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
A6A12_0038	COG0545	Peptidyl-prolyl cis-trans isomerase
A6A12_0039	COG2964	Protein conserved in bacteria
A6A12_0040	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A6A12_0041	COG2923	Belongs to the DsrF TusC family
A6A12_0044	COG0049	tRNA binding
A6A12_0045	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6A12_0046	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6A12_0047	COG0360	Binds together with S18 to 16S ribosomal RNA
A6A12_0048	COG2965	DNA replication, synthesis of RNA primer
A6A12_0050	COG0359	binds to the 23S rRNA
A6A12_0052	COG0305	Participates in initiation and elongation during chromosome replication
A6A12_0053	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6A12_0055	COG0166	Belongs to the GPI family
A6A12_0056	COG2433	Pfam Transposase IS66
A6A12_0060	COG0735	belongs to the Fur family
A6A12_0061	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6A12_0065	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A6A12_0066	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6A12_0067	COG0175	sulfate reduction
A6A12_0079	COG1410	methionine synthase
A6A12_0079	COG0646	methionine synthase
A6A12_0080	COG0527	aspartate kinase activity
A6A12_0082	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A6A12_0085	COG2239	Acts as a magnesium transporter
A6A12_0087	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6A12_0090	COG0629	single-stranded DNA binding
A6A12_0091	COG2199	diguanylate cyclase activity
A6A12_0091	COG2200	EAL domain
A6A12_0096	COG3267	Type II secretory pathway component ExeA
A6A12_0096	COG3409	Peptidoglycan-binding domain 1 protein
A6A12_0098	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6A12_0099	COG1459	type II secretion system
A6A12_0108	COG1077	Cell shape determining protein MreB Mrl
A6A12_0109	COG1792	Involved in formation and maintenance of cell shape
A6A12_0110	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A6A12_0111	COG0424	maF-like protein
A6A12_0112	COG1530	ribonuclease E activity
A6A12_0113	COG3164	Protein of unknown function
A6A12_0114	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6A12_0115	COG0312	modulator of DNA gyrase
A6A12_0117	COG2235	arginine
A6A12_0121	COG0589	response to stress
A6A12_0126	COG0531	amino acid
A6A12_0127	COG0142	geranyltranstransferase activity
A6A12_0129	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A6A12_0130	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A6A12_0131	COG2966	Psort location CytoplasmicMembrane, score
A6A12_0132	COG3610	response to peptide
A6A12_0135	COG2967	ApaG domain
A6A12_0137	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A6A12_0138	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6A12_0139	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A6A12_0140	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A6A12_0151	COG0741	lytic transglycosylase activity
A6A12_0154	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6A12_0155	COG2066	Belongs to the glutaminase family
A6A12_0156	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6A12_0159	COG1872	DUF167
A6A12_0160	COG0762	integral membrane protein
A6A12_0161	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6A12_0162	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6A12_0165	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6A12_0166	COG1678	Uncharacterized ACR, COG1678
A6A12_0168	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6A12_0169	COG2356	endonuclease I
A6A12_0170	COG3091	SprT-like family
A6A12_0171	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A6A12_0173	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A6A12_0174	COG0583	DNA-binding transcription factor activity
A6A12_0175	COG4771	TonB-dependent receptor
A6A12_0177	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6A12_0178	COG0126	phosphoglycerate kinase activity
A6A12_0179	COG0191	fructose-bisphosphate aldolase activity
A6A12_0181	COG0668	transmembrane transport
A6A12_0185	COG3706	GGDEF domain
A6A12_0186	COG0469	pyruvate kinase activity
A6A12_0188	COG1349	DNA-binding transcription factor activity
A6A12_0191	COG4932	domain protein
A6A12_0191	COG5492	domain, Protein
A6A12_0195	COG3501	Rhs element vgr protein
A6A12_0224	COG1484	DNA-dependent DNA replication
A6A12_0225	COG4584	PFAM Integrase catalytic
A6A12_0237	COG2801	Transposase and inactivated derivatives
A6A12_0240	COG0210	DNA helicase
A6A12_0244	COG3550	peptidyl-serine autophosphorylation
A6A12_0247	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6A12_0248	COG0358	DNA primase activity
A6A12_0249	COG1610	YqeY-like protein
A6A12_0255	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A6A12_0256	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6A12_0257	COG1968	undecaprenyl-diphosphatase activity
A6A12_0258	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A6A12_0259	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A6A12_0260	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A6A12_0261	COG0585	pseudouridine synthase activity
A6A12_0262	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A6A12_0263	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A6A12_0264	COG4942	peptidase
A6A12_0264	COG1388	LysM domain
A6A12_0265	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6A12_0266	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A6A12_0268	COG4150	thiosulfate binding
A6A12_0270	COG4208	sulfate ABC transporter
A6A12_0271	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A6A12_0272	COG1546	Belongs to the CinA family
A6A12_0273	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6A12_0274	COG2137	regulation of response to DNA damage stimulus
A6A12_0275	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6A12_0276	COG0527	aspartate kinase activity
A6A12_0283	COG3630	sodium ion export across plasma membrane
A6A12_0284	COG0511	ligase activity, forming carbon-carbon bonds
A6A12_0284	COG5016	pyruvate
A6A12_0285	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A6A12_0286	COG1063	alcohol dehydrogenase
A6A12_0287	COG1238	metal cluster binding
A6A12_0288	COG0612	Peptidase, M16
A6A12_0291	COG4536	flavin adenine dinucleotide binding
A6A12_0292	COG4137	Cytochrome C assembly protein
A6A12_0293	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6A12_0297	COG0335	large ribosomal subunit rRNA binding
A6A12_0298	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A6A12_0299	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
A6A12_0300	COG0237	dephospho-CoA kinase activity
A6A12_0302	COG1459	type II secretion system
A6A12_0303	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6A12_0305	COG0157	Belongs to the NadC ModD family
A6A12_0307	COG0716	FMN binding
A6A12_0308	COG4974	Belongs to the 'phage' integrase family
A6A12_0309	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6A12_0310	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A6A12_0311	COG2186	Transcriptional regulator
A6A12_0312	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A6A12_0313	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6A12_0314	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6A12_0317	COG0288	reversible hydration of carbon dioxide
A6A12_0318	COG0659	secondary active sulfate transmembrane transporter activity
A6A12_0319	COG1131	(ABC) transporter
A6A12_0320	COG0842	Transport permease protein
A6A12_0322	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A6A12_0324	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6A12_0326	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6A12_0327	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6A12_0328	COG1489	DNA binding
A6A12_0329	COG1643	Atp-dependent helicase
A6A12_0330	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6A12_0331	COG1752	Esterase of the alpha-beta hydrolase superfamily
A6A12_0332	COG1049	propionate catabolic process, 2-methylcitrate cycle
A6A12_0334	COG1929	Belongs to the glycerate kinase type-1 family
A6A12_0335	COG2610	gluconate transmembrane transporter activity
A6A12_0336	COG3835	regulator
A6A12_0339	COG0004	ammonium transporteR
A6A12_0340	COG1840	ABC-type Fe3 transport system, periplasmic component
A6A12_0343	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6A12_0346	COG2971	BadF BadG BcrA BcrD
A6A12_0348	COG4608	Belongs to the ABC transporter superfamily
A6A12_0349	COG0444	Belongs to the ABC transporter superfamily
A6A12_0350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6A12_0355	COG0628	permease
A6A12_0357	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A6A12_0358	COG0316	Belongs to the HesB IscA family
A6A12_0361	COG0739	heme binding
A6A12_0362	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6A12_0363	COG2239	Acts as a magnesium transporter
A6A12_0364	COG2027	D-alanyl-D-alanine carboxypeptidase
A6A12_0366	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6A12_0367	COG1534	Rna-binding protein
A6A12_0369	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6A12_0370	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6A12_0371	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6A12_0372	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6A12_0375	COG0779	Required for maturation of 30S ribosomal subunits
A6A12_0376	COG0195	Participates in both transcription termination and antitermination
A6A12_0377	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A6A12_0379	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6A12_0383	COG1846	Transcriptional regulator
A6A12_0389	COG3153	acetyltransferase
A6A12_0394	COG0513	Belongs to the DEAD box helicase family
A6A12_0397	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A6A12_0398	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A6A12_0399	COG2204	response regulator
A6A12_0402	COG0667	Aldo Keto reductase
A6A12_0403	COG3066	DNA modification
A6A12_0404	COG0494	nUDIX hydrolase
A6A12_0406	COG0730	response to heat
A6A12_0408	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A6A12_0417	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A6A12_0419	COG1283	sodium-dependent phosphate transmembrane transporter activity
A6A12_0420	COG0583	DNA-binding transcription factor activity
A6A12_0421	COG0640	Transcriptional regulator
A6A12_0423	COG0728	peptidoglycan biosynthetic process
A6A12_0424	COG0196	riboflavin kinase activity
A6A12_0426	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A6A12_0428	COG1047	Peptidyl-prolyl cis-trans
A6A12_0430	COG1966	Carbon starvation protein
A6A12_0433	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A6A12_0434	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A6A12_0435	COG1472	Belongs to the glycosyl hydrolase 3 family
A6A12_0436	COG3279	Response regulator of the LytR AlgR family
A6A12_0437	COG3275	phosphorelay sensor kinase activity
A6A12_0438	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6A12_0439	COG1605	Chorismate mutase
A6A12_0439	COG0287	Prephenate dehydrogenase
A6A12_0442	COG0488	(ABC) transporter
A6A12_0445	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
A6A12_0446	COG5001	Diguanylate cyclase
A6A12_0447	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A6A12_0448	COG1605	Chorismate mutase
A6A12_0448	COG0077	Prephenate dehydratase
A6A12_0449	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A6A12_0451	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6A12_0452	COG0564	pseudouridine synthase activity
A6A12_0454	COG0542	response to heat
A6A12_0467	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6A12_0470	COG0745	RESPONSE REGULATOR receiver
A6A12_0471	COG5002	protein histidine kinase activity
A6A12_0473	COG0248	Ppx GppA phosphatase
A6A12_0474	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A6A12_0476	COG0581	inorganic phosphate transmembrane transporter activity
A6A12_0477	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6A12_0478	COG0704	Plays a role in the regulation of phosphate uptake
A6A12_0479	COG3142	Participates in the control of copper homeostasis
A6A12_0480	COG0450	alkyl hydroperoxide reductase
A6A12_0481	COG0583	DNA-binding transcription factor activity
A6A12_0482	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A6A12_0485	COG0517	IMP dehydrogenase activity
A6A12_0486	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A6A12_0488	COG1862	Preprotein translocase
A6A12_0489	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6A12_0490	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6A12_0491	COG0483	inositol monophosphate 1-phosphatase activity
A6A12_0492	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A6A12_0493	COG1959	2 iron, 2 sulfur cluster binding
A6A12_0495	COG0822	iron-sulfur transferase activity
A6A12_0496	COG0316	Belongs to the HesB IscA family
A6A12_0498	COG0443	Heat shock 70 kDa protein
A6A12_0499	COG0633	Ferredoxin
A6A12_0500	COG2975	iron-sulfur cluster assembly
A6A12_0501	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6A12_0505	COG1426	Protein conserved in bacteria
A6A12_0506	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A6A12_0507	COG0124	histidyl-tRNA synthetase
A6A12_0508	COG2976	Protein conserved in bacteria
A6A12_0509	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6A12_0510	COG1160	GTP binding
A6A12_0513	COG0516	GMP reductase activity
A6A12_0513	COG0517	IMP dehydrogenase activity
A6A12_0514	COG0519	Catalyzes the synthesis of GMP from XMP
A6A12_0514	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A6A12_0515	COG0351	phosphomethylpyrimidine kinase
A6A12_0517	COG1584	GPR1 FUN34 yaaH family protein
A6A12_0518	COG1115	amino acid carrier protein
A6A12_0519	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6A12_0523	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A6A12_0524	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6A12_0524	COG3711	transcriptional antiterminator
A6A12_0527	COG3964	amidohydrolase
A6A12_0534	COG0556	nucleotide-excision repair
A6A12_0555	COG2003	Belongs to the UPF0758 family
A6A12_0558	COG1715	Restriction endonuclease
A6A12_0559	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
A6A12_0563	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
A6A12_0564	COG0582	viral genome integration into host DNA
A6A12_0566	COG2867	negative regulation of translational initiation
A6A12_0567	COG2914	Belongs to the UPF0125 (RnfH) family
A6A12_0568	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6A12_0569	COG0497	DNA recombination
A6A12_0571	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A6A12_0572	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A6A12_0573	COG0443	Heat shock 70 kDa protein
A6A12_0575	COG0484	heat shock protein binding
A6A12_0581	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A6A12_0582	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A6A12_0584	COG0583	DNA-binding transcription factor activity
A6A12_0585	COG0590	tRNA wobble adenosine to inosine editing
A6A12_0587	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A6A12_0588	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6A12_0588	COG0047	phosphoribosylformylglycinamidine synthase activity
A6A12_0592	COG2979	Protein of unknown function (DUF533)
A6A12_0593	COG0442	prolyl-tRNA aminoacylation
A6A12_0594	COG1720	tRNA m6t6A37 methyltransferase activity
A6A12_0596	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6A12_0603	COG3098	single-species biofilm formation
A6A12_0604	COG0564	pseudouridine synthase activity
A6A12_0605	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A6A12_0606	COG0142	geranyltranstransferase activity
A6A12_0609	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A6A12_0612	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6A12_0612	COG0301	tRNA thio-modification
A6A12_0613	COG0583	DNA-binding transcription factor activity
A6A12_0614	COG2363	Small membrane protein
A6A12_0616	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6A12_0617	COG1611	Belongs to the LOG family
A6A12_0618	COG3706	GGDEF domain
A6A12_0622	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
A6A12_0623	COG1464	Belongs to the NlpA lipoprotein family
A6A12_0624	COG2011	ABC-type metal ion transport system permease component
A6A12_0625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6A12_0626	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6A12_0629	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6A12_0629	COG1263	PTS System
A6A12_0630	COG0366	Alpha amylase catalytic
A6A12_0631	COG0745	RESPONSE REGULATOR receiver
A6A12_0632	COG2205	protein histidine kinase activity
A6A12_0638	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6A12_0639	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6A12_0640	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6A12_0642	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A6A12_0643	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A6A12_0653	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A6A12_0659	COG0489	protein tyrosine kinase activity
A6A12_0660	COG1596	polysaccharide export
A6A12_0664	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6A12_0667	COG0321	lipoyl(octanoyl) transferase activity
A6A12_0668	COG2921	Belongs to the UPF0250 family
A6A12_0669	COG1686	Belongs to the peptidase S11 family
A6A12_0670	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6A12_0671	COG0772	Belongs to the SEDS family
A6A12_0672	COG0768	penicillin binding
A6A12_0673	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A6A12_0674	COG0799	negative regulation of ribosome biogenesis
A6A12_0675	COG1466	dna polymerase III delta subunit
A6A12_0676	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
A6A12_0677	COG0495	leucyl-tRNA aminoacylation
A6A12_0678	COG2888	peptidyl-tyrosine sulfation
A6A12_0679	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A6A12_0680	COG4535	Mg2 and Co2 transporter CorC
A6A12_0682	COG1702	phosphate starvation-inducible protein PhoH
A6A12_0683	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6A12_0684	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6A12_0685	COG2190	(PTS) system
A6A12_0686	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6A12_0687	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6A12_0688	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A6A12_0689	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
A6A12_0690	COG3115	cell septum assembly
A6A12_0695	COG0789	Transcriptional regulator
A6A12_0697	COG0330	HflC and HflK could
A6A12_0699	COG3118	belongs to the thioredoxin family
A6A12_0700	COG1090	epimerase
A6A12_0701	COG0622	Phosphoesterase
A6A12_0704	COG3710	Transcriptional regulator
A6A12_0705	COG0326	Molecular chaperone. Has ATPase activity
A6A12_0707	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A6A12_0708	COG3104	oligopeptide transport
A6A12_0710	COG0367	asparagine synthase
A6A12_0712	COG4651	solute:proton antiporter activity
A6A12_0712	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A6A12_0713	COG1940	carbohydrate kinase activity
A6A12_0713	COG1846	Transcriptional regulator
A6A12_0714	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A6A12_0716	COG1263	PTS System
A6A12_0716	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6A12_0716	COG2190	(PTS) system
A6A12_0717	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6A12_0721	COG0285	dihydrofolate synthase activity
A6A12_0722	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
A6A12_0723	COG1286	toxin biosynthetic process
A6A12_0724	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A6A12_0725	COG2056	Na+-H+ antiporter family
A6A12_0726	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6A12_0729	COG0346	lactoylglutathione lyase activity
A6A12_0730	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6A12_0733	COG4658	electron transport chain
A6A12_0734	COG4656	Part of a membrane complex involved in electron transport
A6A12_0735	COG2878	Part of a membrane complex involved in electron transport
A6A12_0736	COG4657	Part of a membrane complex involved in electron transport
A6A12_0738	COG4774	siderophore transport
A6A12_0738	COG1629	transport
A6A12_0740	COG2382	esterase
A6A12_0742	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6A12_0747	COG3433	isochorismatase activity
A6A12_0747	COG1535	isochorismatase
A6A12_0748	COG1021	2,3-dihydroxybenzoate-AMP ligase
A6A12_0749	COG1169	isochorismate synthase
A6A12_0750	COG1028	Short-chain dehydrogenase reductase Sdr
A6A12_0751	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6A12_0756	COG0556	nucleotide-excision repair
A6A12_0757	COG2204	response regulator
A6A12_0758	COG2198	Histidine kinase
A6A12_0759	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A6A12_0760	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6A12_0761	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6A12_0763	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A6A12_0764	COG0314	molybdopterin synthase activity
A6A12_0765	COG2199	diguanylate cyclase activity
A6A12_0766	COG4109	DRTGG domain
A6A12_0769	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A6A12_0771	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6A12_0771	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6A12_0772	COG0489	protein tyrosine kinase activity
A6A12_0773	COG0572	uridine kinase
A6A12_0774	COG2982	Protein involved in outer membrane biogenesis
A6A12_0775	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
A6A12_0776	COG2067	long-chain fatty acid transport protein
A6A12_0777	COG2067	long-chain fatty acid transport protein
A6A12_0779	COG1595	DNA-templated transcription, initiation
A6A12_0780	COG0183	Belongs to the thiolase family
A6A12_0781	COG1024	Enoyl-CoA hydratase
A6A12_0781	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6A12_0782	COG0778	Nitroreductase
A6A12_0783	COG0583	DNA-binding transcription factor activity
A6A12_0784	COG0745	RESPONSE REGULATOR receiver
A6A12_0786	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6A12_0788	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A6A12_0794	COG2226	methyltransferase
A6A12_0797	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6A12_0799	COG3139	Protein of unknown function (DUF1315)
A6A12_0800	COG0252	asparaginase activity
A6A12_0801	COG0616	signal peptide processing
A6A12_0802	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6A12_0802	COG1902	pentaerythritol trinitrate reductase activity
A6A12_0803	COG0788	formyltetrahydrofolate deformylase activity
A6A12_0805	COG1199	ATP-dependent helicase activity
A6A12_0806	COG1214	PFAM Peptidase M22, glycoprotease
A6A12_0809	COG0596	Alpha beta hydrolase
A6A12_0810	COG0318	PFAM AMP-dependent synthetase and ligase
A6A12_0811	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A6A12_0813	COG2894	cell division
A6A12_0815	COG3100	YcgL domain-containing protein
A6A12_0816	COG2951	lytic endotransglycosylase activity
A6A12_0817	COG0583	DNA-binding transcription factor activity
A6A12_0818	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6A12_0824	COG4628	conserved protein (DUF2132)
A6A12_0827	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6A12_0829	COG0513	Belongs to the DEAD box helicase family
A6A12_0831	COG1760	l-serine dehydratase
A6A12_0832	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A6A12_0833	COG0745	RESPONSE REGULATOR receiver
A6A12_0834	COG2205	protein histidine kinase activity
A6A12_0835	COG1653	transport
A6A12_0836	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A6A12_0837	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A6A12_0838	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A6A12_0842	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6A12_0845	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A6A12_0846	COG0776	regulation of translation
A6A12_0847	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6A12_0848	COG1555	photosystem II stabilization
A6A12_0849	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A6A12_0850	COG0539	negative regulation of cytoplasmic translation
A6A12_0852	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
A6A12_0853	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A6A12_0856	COG0583	DNA-binding transcription factor activity
A6A12_0858	COG0686	Belongs to the AlaDH PNT family
A6A12_0859	COG1522	sequence-specific DNA binding
A6A12_0860	COG1674	ftsk spoiiie
A6A12_0862	COG0501	Belongs to the peptidase M48B family
A6A12_0864	COG0300	oxidoreductase activity
A6A12_0867	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6A12_0869	COG2268	Band 7 protein
A6A12_0871	COG1032	radical SAM domain protein
A6A12_0873	COG2199	diguanylate cyclase activity
A6A12_0873	COG2203	Gaf domain
A6A12_0873	COG2200	EAL domain
A6A12_0876	COG0583	DNA-binding transcription factor activity
A6A12_0877	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A6A12_0879	COG2350	Protein conserved in bacteria
A6A12_0880	COG1607	acyl-coa hydrolase
A6A12_0887	COG0133	tryptophan synthase activity
A6A12_0888	COG0134	indole-3-glycerol-phosphate synthase activity
A6A12_0888	COG0135	phosphoribosylanthranilate isomerase activity
A6A12_0889	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6A12_0890	COG0512	Glutamine amidotransferase of anthranilate synthase
A6A12_0891	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6A12_0893	COG0613	PHP domain protein
A6A12_0894	COG0009	L-threonylcarbamoyladenylate synthase
A6A12_0895	COG1187	pseudouridine synthase activity
A6A12_0898	COG1595	DNA-templated transcription, initiation
A6A12_0901	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A6A12_0902	COG4988	ABC transporter
A6A12_0903	COG0492	ferredoxin-NADP+ reductase activity
A6A12_0904	COG0745	RESPONSE REGULATOR receiver
A6A12_0904	COG3706	GGDEF domain
A6A12_0907	COG2949	membrane
A6A12_0909	COG0281	malic enzyme
A6A12_0915	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6A12_0917	COG1737	Transcriptional regulator
A6A12_0918	COG0076	glutamate decarboxylase activity
A6A12_0920	COG2431	L-lysine efflux transmembrane transporter activity
A6A12_0922	COG3070	regulator of competence-specific genes
A6A12_0926	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6A12_0926	COG4191	Histidine kinase
A6A12_0928	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A6A12_0929	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6A12_0930	COG2915	High frequency lysogenization protein hflD homolog
A6A12_0931	COG0482	sulfurtransferase activity
A6A12_0933	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6A12_0934	COG2916	Histone family protein nucleoid-structuring protein H-NS
A6A12_0935	COG1757	Na H antiporter
A6A12_0938	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A6A12_0939	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6A12_0940	COG0131	Imidazoleglycerol-phosphate dehydratase
A6A12_0940	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6A12_0941	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A6A12_0942	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A6A12_0943	COG0107	imidazoleglycerol-phosphate synthase activity
A6A12_0944	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A6A12_0944	COG0140	phosphoribosyl-ATP diphosphatase activity
A6A12_0945	COG1187	pseudouridine synthase activity
A6A12_0947	COG1278	Cold shock
A6A12_0950	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A6A12_0951	COG0542	response to heat
A6A12_0952	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6A12_0953	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A6A12_0954	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A6A12_0955	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A6A12_0959	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6A12_0960	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6A12_0961	COG0297	glycogen (starch) synthase activity
A6A12_0965	COG3070	regulator of competence-specific genes
A6A12_0966	COG1609	Transcriptional regulator
A6A12_0968	COG0745	RESPONSE REGULATOR receiver
A6A12_0969	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A6A12_0970	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6A12_0972	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
A6A12_0973	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A6A12_0976	COG4067	protein conserved in archaea
A6A12_0976	COG0189	ligase activity
A6A12_0980	COG1801	Protein of unknown function DUF72
A6A12_0981	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6A12_0982	COG1435	thymidine kinase activity
A6A12_0983	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A6A12_0988	COG2116	formate transmembrane transporter activity
A6A12_0989	COG4459	periplasmic nitrate reductase
A6A12_0990	COG3005	denitrification pathway
A6A12_0991	COG0243	molybdopterin cofactor binding
A6A12_0993	COG1227	inorganic diphosphatase activity
A6A12_0996	COG4172	Belongs to the ABC transporter superfamily
A6A12_0998	COG4171	peptide transport system, permease
A6A12_0999	COG4168	peptide transport system, permease
A6A12_1001	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A6A12_1002	COG1842	Phage shock protein A
A6A12_1005	COG0519	Catalyzes the synthesis of GMP from XMP
A6A12_1006	COG0626	cystathionine gamma-synthase activity
A6A12_1008	COG0733	neurotransmitter:sodium symporter activity
A6A12_1009	COG0564	pseudouridine synthase activity
A6A12_1011	COG2200	EAL domain
A6A12_1011	COG2771	luxR family
A6A12_1013	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6A12_1014	COG4136	ATPase activity
A6A12_1015	COG4135	transport system, permease component
A6A12_1016	COG4134	Bacterial extracellular solute-binding protein
A6A12_1018	COG3313	Fe-S protein
A6A12_1020	COG0737	Belongs to the 5'-nucleotidase family
A6A12_1024	COG0513	Belongs to the DEAD box helicase family
A6A12_1028	COG2205	protein histidine kinase activity
A6A12_1031	COG1061	Type III restriction enzyme res subunit
A6A12_1032	COG1187	pseudouridine synthase activity
A6A12_1033	COG2814	Major facilitator Superfamily
A6A12_1035	COG0702	epimerase
A6A12_1036	COG0534	Mate efflux family protein
A6A12_1037	COG4181	ATPase activity
A6A12_1040	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6A12_1043	COG0019	diaminopimelate decarboxylase activity
A6A12_1044	COG0840	transmembrane signaling receptor activity
A6A12_1052	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6A12_1053	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6A12_1055	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6A12_1057	COG0840	transmembrane signaling receptor activity
A6A12_1065	COG0511	ligase activity, forming carbon-carbon bonds
A6A12_1065	COG5016	pyruvate
A6A12_1066	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A6A12_1068	COG4565	transcriptional regulatory protein
A6A12_1069	COG3052	prosthetic group binding
A6A12_1070	COG2301	Belongs to the HpcH HpaI aldolase family
A6A12_1071	COG3051	citrate lyase alpha subunit
A6A12_1072	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
A6A12_1073	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
A6A12_1078	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6A12_1078	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6A12_1078	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6A12_1079	COG2207	Transcriptional regulator
A6A12_1081	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6A12_1083	COG1342	Belongs to the UPF0251 family
A6A12_1087	COG1129	ABC transporter
A6A12_1089	COG0583	DNA-binding transcription factor activity
A6A12_1090	COG1902	pentaerythritol trinitrate reductase activity
A6A12_1091	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A6A12_1092	COG5002	protein histidine kinase activity
A6A12_1093	COG0745	RESPONSE REGULATOR receiver
A6A12_1099	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A6A12_1100	COG0372	Belongs to the citrate synthase family
A6A12_1101	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A6A12_1102	COG2828	Protein conserved in bacteria
A6A12_1106	COG0561	phosphatase activity
A6A12_1108	COG0602	queuosine metabolic process
A6A12_1114	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6A12_1116	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6A12_1117	COG1254	Belongs to the acylphosphatase family
A6A12_1118	COG2920	part of a sulfur-relay system
A6A12_1119	COG0670	Belongs to the BI1 family
A6A12_1120	COG1126	abc transporter atp-binding protein
A6A12_1121	COG0765	amino acid transport
A6A12_1122	COG4597	amino acid ABC transporter
A6A12_1123	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6A12_1124	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6A12_1124	COG1648	precorrin-2 dehydrogenase activity
A6A12_1126	COG3706	GGDEF domain
A6A12_1126	COG0745	RESPONSE REGULATOR receiver
A6A12_1128	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6A12_1133	COG2996	Protein conserved in bacteria
A6A12_1135	COG3008	intermembrane lipid transfer
A6A12_1136	COG2995	paraquat-inducible protein a
A6A12_1137	COG1132	(ABC) transporter
A6A12_1138	COG1956	GAF domain-containing protein
A6A12_1142	COG0308	aminopeptidase N
A6A12_1143	COG2902	Dehydrogenase
A6A12_1144	COG0167	dihydroorotate dehydrogenase activity
A6A12_1146	COG0116	Belongs to the methyltransferase superfamily
A6A12_1146	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6A12_1151	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6A12_1152	COG1067	ATP-dependent peptidase activity
A6A12_1153	COG3120	sequence-specific DNA binding
A6A12_1157	COG3278	Belongs to the heme-copper respiratory oxidase family
A6A12_1160	COG2010	Cytochrome c
A6A12_1162	COG2217	Heavy metal translocating P-type atpase
A6A12_1165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6A12_1166	COG0589	response to stress
A6A12_1171	COG3842	ATPase activity
A6A12_1172	COG1176	ABC-type spermidine putrescine transport system, permease component I
A6A12_1173	COG1177	transmembrane transport
A6A12_1174	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A6A12_1175	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A6A12_1176	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A6A12_1177	COG0004	ammonium transporteR
A6A12_1178	COG0488	(ABC) transporter
A6A12_1179	COG2197	response regulator
A6A12_1181	COG2271	Major facilitator Superfamily
A6A12_1182	COG1840	ABC-type Fe3 transport system, periplasmic component
A6A12_1184	COG3842	ATPase activity
A6A12_1186	COG0746	molybdenum cofactor guanylyltransferase activity
A6A12_1187	COG1763	Mo-molybdopterin cofactor biosynthetic process
A6A12_1193	COG0840	transmembrane signaling receptor activity
A6A12_1194	COG0791	NLP P60 protein
A6A12_1199	COG1793	dna ligase
A6A12_1200	COG4667	esterase of the alpha-beta hydrolase superfamily
A6A12_1203	COG0848	biopolymer transport protein
A6A12_1204	COG0811	peptide transport
A6A12_1205	COG0811	peptide transport
A6A12_1211	COG0625	glutathione transferase activity
A6A12_1213	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
A6A12_1215	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6A12_1218	COG1115	amino acid carrier protein
A6A12_1219	COG1280	lysine exporter protein (LysE YggA)
A6A12_1220	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A6A12_1222	COG2433	Pfam Transposase IS66
A6A12_1226	COG1204	response to ionizing radiation
A6A12_1233	COG0673	inositol 2-dehydrogenase activity
A6A12_1240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6A12_1241	COG3962	Belongs to the TPP enzyme family
A6A12_1242	COG3718	enzyme involved in inositol metabolism
A6A12_1245	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A6A12_1245	COG0517	IMP dehydrogenase activity
A6A12_1246	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6A12_1247	COG0673	inositol 2-dehydrogenase activity
A6A12_1252	COG0477	Major facilitator Superfamily
A6A12_1253	COG0583	DNA-binding transcription factor activity
A6A12_1255	COG1643	Atp-dependent helicase
A6A12_1259	COG5002	protein histidine kinase activity
A6A12_1259	COG5001	Diguanylate cyclase
A6A12_1262	COG0443	Heat shock 70 kDa protein
A6A12_1269	COG1609	Transcriptional regulator
A6A12_1270	COG2723	6-phospho-beta-galactosidase activity
A6A12_1271	COG0513	Belongs to the DEAD box helicase family
A6A12_1272	COG0243	molybdopterin cofactor binding
A6A12_1273	COG3005	denitrification pathway
A6A12_1274	COG1278	Cold shock
A6A12_1278	COG4191	Histidine kinase
A6A12_1278	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6A12_1279	COG0471	metal ion transport
A6A12_1282	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6A12_1284	COG3706	GGDEF domain
A6A12_1286	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6A12_1287	COG3283	Transcriptional regulator of aromatic amino acids metabolism
A6A12_1288	COG3768	UPF0283 membrane protein
A6A12_1289	COG3106	COG3106 Predicted ATPase
A6A12_1292	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6A12_1293	COG0494	nUDIX hydrolase
A6A12_1294	COG0814	amino acid
A6A12_1295	COG1760	l-serine dehydratase
A6A12_1298	COG2356	endonuclease I
A6A12_1299	COG0720	synthase
A6A12_1300	COG0840	transmembrane signaling receptor activity
A6A12_1301	COG0017	Asparaginyl-tRNA synthetase
A6A12_1303	COG2201	protein-glutamate methylesterase activity
A6A12_1304	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A6A12_1305	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A6A12_1306	COG0835	chemotaxis
A6A12_1308	COG2198	Histidine kinase
A6A12_1308	COG0643	Histidine kinase
A6A12_1310	COG0745	RESPONSE REGULATOR receiver
A6A12_1311	COG0840	transmembrane signaling receptor activity
A6A12_1312	COG2770	Histidine kinase
A6A12_1312	COG3437	response regulator, receiver
A6A12_1313	COG1448	Aminotransferase
A6A12_1314	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
A6A12_1317	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6A12_1318	COG1846	Transcriptional regulator
A6A12_1321	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6A12_1322	COG3108	Peptidase M15
A6A12_1323	COG2989	Protein conserved in bacteria
A6A12_1329	COG1940	carbohydrate kinase activity
A6A12_1330	COG1629	transport
A6A12_1330	COG4771	TonB-dependent receptor
A6A12_1331	COG0748	coenzyme F420 binding
A6A12_1332	COG3721	Heme iron utilization protein
A6A12_1334	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
A6A12_1335	COG0811	peptide transport
A6A12_1336	COG0848	biopolymer transport protein
A6A12_1338	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6A12_1339	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A6A12_1342	COG0840	transmembrane signaling receptor activity
A6A12_1343	COG1621	beta-fructofuranosidase activity
A6A12_1345	COG1263	PTS System
A6A12_1345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6A12_1346	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6A12_1347	COG2200	EAL domain
A6A12_1348	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A6A12_1349	COG0840	transmembrane signaling receptor activity
A6A12_1355	COG3220	belongs to the UPF0276 family
A6A12_1359	COG1294	oxidase, subunit
A6A12_1360	COG0251	oxidation-reduction process
A6A12_1364	COG2433	Pfam Transposase IS66
A6A12_1372	COG0515	serine threonine protein kinase
A6A12_1372	COG3064	Membrane
A6A12_1372	COG4991	sh3 domain protein
A6A12_1377	COG1716	ATPase activity
A6A12_1381	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6A12_1393	COG3501	Rhs element vgr protein
A6A12_1398	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A6A12_1403	COG0745	RESPONSE REGULATOR receiver
A6A12_1403	COG3706	GGDEF domain
A6A12_1406	COG0835	chemotaxis
A6A12_1406	COG0784	Response regulator, receiver
A6A12_1408	COG4565	transcriptional regulatory protein
A6A12_1409	COG3290	protein histidine kinase activity
A6A12_1412	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6A12_1417	COG3063	Type IV pilus biogenesis stability protein PilW
A6A12_1420	COG1451	nucleotide metabolic process
A6A12_1422	COG0583	DNA-binding transcription factor activity
A6A12_1427	COG4139	cobalamin transport
A6A12_1428	COG2988	succinylglutamate desuccinylase activity
A6A12_1431	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A6A12_1433	COG1073	alpha beta
A6A12_1433	COG3064	Membrane
A6A12_1433	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
A6A12_1434	COG2994	toxin metabolic process
A6A12_1441	COG0702	epimerase
A6A12_1443	COG2925	Exonuclease
A6A12_1445	COG1346	cytolysis
A6A12_1446	COG0295	cytidine deaminase activity
A6A12_1447	COG5001	Diguanylate cyclase
A6A12_1448	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A6A12_1450	COG0500	methyltransferase
A6A12_1453	COG0072	phenylalanine-tRNA ligase activity
A6A12_1453	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6A12_1462	COG0322	excinuclease ABC activity
A6A12_1463	COG2197	response regulator
A6A12_1464	COG0417	DNA replication proofreading
A6A12_1466	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6A12_1467	COG3099	Belongs to the UPF0263 family
A6A12_1470	COG1228	amidohydrolase
A6A12_1471	COG0010	Belongs to the arginase family
A6A12_1473	COG2986	histidine ammonia-lyase
A6A12_1476	COG0277	FAD linked oxidase domain protein
A6A12_1476	COG0247	lactate metabolic process
A6A12_1482	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6A12_1483	COG1960	acyl-CoA dehydrogenase activity
A6A12_1488	COG3300	MHYT domain
A6A12_1488	COG5001	Diguanylate cyclase
A6A12_1515	COG0740	serine-type endopeptidase activity
A6A12_1518	COG4626	Terminase
A6A12_1518	COG1802	Transcriptional regulator
A6A12_1524	COG3772	lysozyme
A6A12_1530	COG1403	HNH endonuclease
A6A12_1556	COG2404	hydrolase activity, acting on ester bonds
A6A12_1576	COG0582	viral genome integration into host DNA
A6A12_1579	COG0784	Response regulator, receiver
A6A12_1579	COG5002	protein histidine kinase activity
A6A12_1583	COG2433	Pfam Transposase IS66
A6A12_1585	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
A6A12_1586	COG2885	chlorophyll binding
A6A12_1590	COG0811	peptide transport
A6A12_1591	COG0824	Thioesterase
A6A12_1592	COG3790	cyd operon protein YbgE
A6A12_1593	COG1294	oxidase, subunit
A6A12_1594	COG1271	oxidase subunit
A6A12_1595	COG2255	four-way junction helicase activity
A6A12_1596	COG0632	four-way junction helicase activity
A6A12_1597	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A6A12_1598	COG0215	cysteine-tRNA ligase activity
A6A12_1599	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6A12_1600	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6A12_1601	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A6A12_1602	COG3012	SEC-C Motif Domain Protein
A6A12_1604	COG1199	ATP-dependent helicase activity
A6A12_1606	COG3923	Primosomal replication protein n
A6A12_1608	COG0840	transmembrane signaling receptor activity
A6A12_1609	COG0708	Exodeoxyribonuclease III
A6A12_1610	COG4160	amino acid transport
A6A12_1611	COG4215	(ABC) transporter
A6A12_1616	COG1882	Formate acetyltransferase
A6A12_1619	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6A12_1622	COG2766	serine protein kinase
A6A12_1623	COG2718	Belongs to the UPF0229 family
A6A12_1624	COG2719	SpoVR family
A6A12_1626	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A6A12_1629	COG1132	(ABC) transporter
A6A12_1630	COG0658	competence protein
A6A12_1630	COG2333	competence protein COMEC
A6A12_1632	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6A12_1633	COG1136	(ABC) transporter
A6A12_1634	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6A12_1636	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6A12_1639	COG1252	NADH dehydrogenase
A6A12_1645	COG0537	adenosine 5'-monophosphoramidase activity
A6A12_1648	COG2186	Transcriptional regulator
A6A12_1650	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6A12_1652	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A6A12_1653	COG2226	methyltransferase
A6A12_1654	COG0156	8-amino-7-oxononanoate synthase activity
A6A12_1656	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A6A12_1658	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6A12_1659	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A6A12_1660	COG0653	protein targeting
A6A12_1661	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6A12_1663	COG4120	Belongs to the binding-protein-dependent transport system permease family
A6A12_1665	COG3092	negative regulation of chromosome organization
A6A12_1666	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A6A12_1667	COG0280	phosphate acetyltransferase
A6A12_1667	COG0857	belongs to the CobB CobQ family
A6A12_1668	COG0435	Glutathione S-transferase
A6A12_1670	COG0444	Belongs to the ABC transporter superfamily
A6A12_1671	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6A12_1672	COG0601	transmembrane transport
A6A12_1675	COG5002	protein histidine kinase activity
A6A12_1675	COG0784	Response regulator, receiver
A6A12_1682	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6A12_1683	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6A12_1687	COG1216	Glycosyl transferase, family 2
A6A12_1693	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6A12_1694	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6A12_1695	COG1028	Short-chain dehydrogenase reductase Sdr
A6A12_1700	COG0800	Aldolase
A6A12_1701	COG2610	gluconate transmembrane transporter activity
A6A12_1702	COG3265	gluconokinase activity
A6A12_1703	COG0129	dihydroxy-acid dehydratase activity
A6A12_1704	COG1609	Transcriptional regulator
A6A12_1707	COG5002	protein histidine kinase activity
A6A12_1707	COG3850	Histidine kinase
A6A12_1709	COG2985	domain, Protein
A6A12_1713	COG2194	sulfuric ester hydrolase activity
A6A12_1714	COG0642	Histidine kinase
A6A12_1715	COG0745	RESPONSE REGULATOR receiver
A6A12_1717	COG4221	oxidoreductase activity
A6A12_1719	COG1022	Amp-dependent synthetase and ligase
A6A12_1723	COG3706	GGDEF domain
A6A12_1726	COG3126	Type III secretion system lipoprotein chaperone (YscW)
A6A12_1727	COG1946	Acyl-CoA thioesterase
A6A12_1728	COG1522	sequence-specific DNA binding
A6A12_1736	COG1441	menaquinone biosynthetic process
A6A12_1737	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A6A12_1739	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A6A12_1740	COG1169	isochorismate synthase
A6A12_1741	COG0436	Aminotransferase
A6A12_1742	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A6A12_1743	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A6A12_1746	COG0616	signal peptide processing
A6A12_1747	COG1028	Short-chain dehydrogenase reductase Sdr
A6A12_1748	COG0784	Response regulator, receiver
A6A12_1748	COG0835	chemotaxis
A6A12_1749	COG1940	carbohydrate kinase activity
A6A12_1751	COG4667	esterase of the alpha-beta hydrolase superfamily
A6A12_1753	COG0733	neurotransmitter:sodium symporter activity
A6A12_1754	COG1263	PTS System
A6A12_1754	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6A12_1755	COG0084	hydrolase, TatD family'
A6A12_1756	COG0470	DNA polymerase III
A6A12_1757	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A6A12_1758	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6A12_1759	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6A12_1764	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6A12_1766	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A6A12_1767	COG1399	metal-binding, possibly nucleic acid-binding protein
A6A12_1768	COG0424	maF-like protein
A6A12_1769	COG0564	pseudouridine synthase activity
A6A12_1770	COG1530	ribonuclease E activity
A6A12_1772	COG1012	belongs to the aldehyde dehydrogenase family
A6A12_1772	COG1454	alcohol dehydrogenase
A6A12_1774	COG2095	MarC family integral membrane protein
A6A12_1775	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6A12_1776	COG1757	Na H antiporter
A6A12_1779	COG3082	Protein of unknown function (DUF1414)
A6A12_1780	COG3083	sulfuric ester hydrolase activity
A6A12_1782	COG0243	molybdopterin cofactor binding
A6A12_1783	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A6A12_1790	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6A12_1791	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A6A12_1796	COG2853	Lipoprotein
A6A12_1799	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6A12_1800	COG1138	Cytochrome C-type biogenesis protein
A6A12_1801	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A6A12_1803	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6A12_1804	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6A12_1805	COG4133	protoheme IX ABC transporter activity
A6A12_1807	COG0835	chemotaxis
A6A12_1809	COG1192	Involved in chromosome partitioning
A6A12_1810	COG2201	protein-glutamate methylesterase activity
A6A12_1811	COG0643	Histidine kinase
A6A12_1811	COG2198	Histidine kinase
A6A12_1812	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
A6A12_1815	COG0455	bacterial-type flagellum organization
A6A12_1817	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A6A12_1818	COG2062	phosphohistidine phosphatase, SixA
A6A12_1819	COG1025	Belongs to the peptidase M16 family
A6A12_1820	COG3102	Protein conserved in bacteria
A6A12_1825	COG1918	ferrous iron import across plasma membrane
A6A12_1826	COG4977	sequence-specific DNA binding
A6A12_1827	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A6A12_1828	COG1121	(ABC) transporter
A6A12_1829	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6A12_1832	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6A12_1833	COG0567	Dehydrogenase, E1 component
A6A12_1836	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A6A12_1837	COG2009	succinate dehydrogenase
A6A12_1839	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A6A12_1841	COG0033	Phosphoglucomutase
A6A12_1842	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
A6A12_1843	COG0596	Alpha beta hydrolase
A6A12_1845	COG0716	FMN binding
A6A12_1846	COG1346	cytolysis
A6A12_1848	COG0583	DNA-binding transcription factor activity
A6A12_1850	COG0735	belongs to the Fur family
A6A12_1851	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6A12_1852	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6A12_1853	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6A12_1854	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A6A12_1854	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6A12_1855	COG0431	NADPH-dependent FMN reductase
A6A12_1858	COG3101	peptidyl-lysine hydroxylation
A6A12_1860	COG2860	membrane
A6A12_1861	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A6A12_1862	COG2890	protein-(glutamine-N5) methyltransferase activity
A6A12_1863	COG2840	Smr protein MutS2
A6A12_1865	COG1684	flagellar biosynthetic protein fliR
A6A12_1866	COG1987	bacterial-type flagellum assembly
A6A12_1876	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A6A12_1878	COG1677	Flagellar hook-basal body complex protein FliE
A6A12_1879	COG2204	response regulator
A6A12_1880	COG4191	Histidine kinase
A6A12_1881	COG2204	response regulator
A6A12_1883	COG1516	flagellar protein fliS
A6A12_1885	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A6A12_1891	COG2837	iron assimilation
A6A12_1896	COG1393	Belongs to the ArsC family
A6A12_1897	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6A12_1901	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6A12_1903	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6A12_1909	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6A12_1911	COG2801	Transposase and inactivated derivatives
A6A12_1920	COG0210	DNA helicase
A6A12_1925	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6A12_1930	COG4783	chaperone-mediated protein folding
A6A12_1931	COG1393	Belongs to the ArsC family
A6A12_1935	COG2233	PERMEase
A6A12_1936	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A6A12_1938	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A6A12_1939	COG2912	Transglutaminase-like superfamily
A6A12_1940	COG3094	Invasion gene expression up-regulator, SirB
A6A12_1941	COG2890	protein-(glutamine-N5) methyltransferase activity
A6A12_1942	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6A12_1943	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A6A12_1944	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A6A12_1948	COG0193	aminoacyl-tRNA hydrolase activity
A6A12_1959	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6A12_1961	COG3951	Flagellar rod assembly protein muramidase FlgJ
A6A12_1961	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6A12_1962	COG1706	bacterial-type flagellum-dependent cell motility
A6A12_1963	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A6A12_1964	COG4786	Flagellar basal body rod
A6A12_1965	COG4787	bacterial-type flagellum-dependent cell motility
A6A12_1966	COG1749	Flagellar hook protein flgE
A6A12_1967	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A6A12_1968	COG1558	bacterial-type flagellum-dependent cell motility
A6A12_1969	COG1815	bacterial-type flagellum-dependent cell motility
A6A12_1971	COG0784	Response regulator, receiver
A6A12_1971	COG0835	chemotaxis
A6A12_1973	COG2747	anti-sigma28 factor FlgM
A6A12_1982	COG2217	Heavy metal translocating P-type atpase
A6A12_1982	COG2608	mercury ion transmembrane transporter activity
A6A12_1989	COG1187	pseudouridine synthase activity
A6A12_1990	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A6A12_1991	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A6A12_1992	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6A12_1993	COG0121	glutamine amidotransferase
A6A12_1994	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A6A12_1997	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6A12_1999	COG2226	methyltransferase
A6A12_2000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6A12_2001	COG1388	LysM domain
A6A12_2001	COG0741	lytic transglycosylase activity
A6A12_2004	COG0347	Belongs to the P(II) protein family
A6A12_2006	COG0037	tRNA processing
A6A12_2007	COG0825	malonyl-CoA metabolic process
A6A12_2008	COG0587	DNA-directed DNA polymerase activity
A6A12_2010	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6A12_2012	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6A12_2013	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6A12_2014	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
A6A12_2016	COG0750	zinc metalloprotease
A6A12_2017	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A6A12_2018	COG0575	Belongs to the CDS family
A6A12_2019	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6A12_2020	COG0233	cytoplasmic translational termination
A6A12_2022	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A6A12_2023	COG0052	Belongs to the universal ribosomal protein uS2 family
A6A12_2024	COG0024	Methionine aminopeptidase
A6A12_2027	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A6A12_2028	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A6A12_2033	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6A12_2033	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6A12_2035	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A6A12_2036	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6A12_2040	COG2252	PERMEase
A6A12_2041	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6A12_2043	COG4067	protein conserved in archaea
A6A12_2043	COG0189	ligase activity
A6A12_2044	COG0189	ligase activity
A6A12_2046	COG0733	neurotransmitter:sodium symporter activity
A6A12_2047	COG5001	Diguanylate cyclase
A6A12_2047	COG4251	negative regulation of phosphorylation
A6A12_2047	COG3706	GGDEF domain
A6A12_2047	COG2203	Gaf domain
A6A12_2050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6A12_2052	COG1477	protein flavinylation
A6A12_2060	COG0271	Belongs to the BolA IbaG family
A6A12_2064	COG2211	Major facilitator Superfamily
A6A12_2066	COG1595	DNA-templated transcription, initiation
A6A12_2069	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A6A12_2071	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6A12_2072	COG2166	iron-sulfur cluster assembly
A6A12_2073	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A6A12_2074	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A6A12_2077	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6A12_2077	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A6A12_2079	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6A12_2080	COG1074	ATP-dependent DNA helicase activity
A6A12_2081	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A6A12_2084	COG3141	response to X-ray
A6A12_2085	COG2171	N-acyltransferase activity
A6A12_2091	COG1609	Transcriptional regulator
A6A12_2093	COG1085	galactose-1-phosphate uridylyltransferase
A6A12_2094	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6A12_2096	COG0534	Mate efflux family protein
A6A12_2098	COG0784	Response regulator, receiver
A6A12_2098	COG3437	response regulator, receiver
A6A12_2099	COG1022	Amp-dependent synthetase and ligase
A6A12_2100	COG4628	conserved protein (DUF2132)
A6A12_2101	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6A12_2102	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A6A12_2104	COG0560	Phosphoserine phosphatase
A6A12_2106	COG0813	purine-nucleoside phosphorylase activity
A6A12_2107	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A6A12_2109	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A6A12_2110	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6A12_2111	COG0084	hydrolase, TatD family'
A6A12_2114	COG1115	amino acid carrier protein
A6A12_2119	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6A12_2120	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A6A12_2121	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
A6A12_2122	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A6A12_2123	COG0083	homoserine kinase activity
A6A12_2126	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A6A12_2127	COG0745	RESPONSE REGULATOR receiver
A6A12_2129	COG5002	protein histidine kinase activity
A6A12_2129	COG2198	Histidine kinase
A6A12_2129	COG0784	Response regulator, receiver
A6A12_2130	COG1242	4 iron, 4 sulfur cluster binding
A6A12_2131	COG0067	glutamate synthase
A6A12_2131	COG0069	glutamate synthase activity
A6A12_2131	COG0070	glutamate synthase
A6A12_2133	COG0070	glutamate synthase
A6A12_2133	COG0069	glutamate synthase activity
A6A12_2133	COG0067	glutamate synthase
A6A12_2134	COG0493	'glutamate synthase
A6A12_2138	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6A12_2139	COG2860	membrane
A6A12_2140	COG0730	response to heat
A6A12_2142	COG0505	Belongs to the CarA family
A6A12_2145	COG0494	nUDIX hydrolase
A6A12_2146	COG0653	protein targeting
A6A12_2148	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A6A12_2149	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A6A12_2150	COG0849	cell division
A6A12_2151	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A6A12_2152	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6A12_2153	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A6A12_2154	COG0772	Belongs to the SEDS family
A6A12_2155	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6A12_2156	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6A12_2157	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6A12_2158	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6A12_2159	COG0768	penicillin binding
A6A12_2160	COG3116	cell division
A6A12_2162	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A6A12_2164	COG3107	peptidoglycan biosynthetic process
A6A12_2166	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A6A12_2168	COG2969	positive regulation of protein catabolic process
A6A12_2169	COG0625	glutathione transferase activity
A6A12_2170	COG2857	Cytochrome c1
A6A12_2171	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A6A12_2172	COG0723	plastoquinol--plastocyanin reductase activity
A6A12_2175	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A6A12_2176	COG3105	Protein conserved in bacteria
A6A12_2177	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6A12_2178	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6A12_2179	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6A12_2180	COG0187	DNA topoisomerase II activity
A6A12_2181	COG3150	esterase
A6A12_2183	COG3151	Protein conserved in bacteria
A6A12_2184	COG0494	nUDIX hydrolase
A6A12_2185	COG1538	Outer membrane efflux protein
A6A12_2187	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A6A12_2190	COG3025	triphosphatase activity
A6A12_2192	COG1392	Phosphate transport regulator
A6A12_2193	COG0306	phosphate transporter
A6A12_2194	COG4991	sh3 domain protein
A6A12_2196	COG3267	Type II secretory pathway component ExeA
A6A12_2196	COG3409	Peptidoglycan-binding domain 1 protein
A6A12_2197	COG0617	tRNA 3'-terminal CCA addition
A6A12_2199	COG0504	CTP synthase activity
A6A12_2200	COG3956	TIGRFAM MazG family protein
A6A12_2201	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6A12_2202	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6A12_2203	COG2205	protein histidine kinase activity
A6A12_2203	COG3437	response regulator, receiver
A6A12_2203	COG3850	Histidine kinase
A6A12_2203	COG4999	Histidine kinase
A6A12_2204	COG0736	holo-[acyl-carrier-protein] synthase activity
A6A12_2209	COG0681	Belongs to the peptidase S26 family
A6A12_2210	COG0481	GTPase activity
A6A12_2211	COG3086	response to oxidative stress
A6A12_2214	COG1595	DNA-templated transcription, initiation
A6A12_2216	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A6A12_2218	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A6A12_2219	COG0354	folic acid binding
A6A12_2221	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6A12_2222	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6A12_2225	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
A6A12_2226	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6A12_2228	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6A12_2230	COG0028	Belongs to the TPP enzyme family
A6A12_2231	COG1022	Amp-dependent synthetase and ligase
A6A12_2232	COG0583	DNA-binding transcription factor activity
A6A12_2237	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6A12_2238	COG0473	3-isopropylmalate dehydrogenase activity
A6A12_2240	COG0066	3-isopropylmalate dehydratase activity
A6A12_2254	COG0795	lipopolysaccharide-transporting ATPase activity
A6A12_2255	COG0795	lipopolysaccharide-transporting ATPase activity
A6A12_2256	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6A12_2257	COG2927	DNA polymerase III (CHI subunit)
A6A12_2258	COG0525	valine-tRNA ligase activity
A6A12_2259	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6A12_2260	COG0564	pseudouridine synthase activity
A6A12_2262	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A6A12_2264	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A6A12_2267	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
A6A12_2268	COG0251	oxidation-reduction process
A6A12_2271	COG0204	Acyl-transferase
A6A12_2272	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6A12_2273	COG5007	Belongs to the BolA IbaG family
A6A12_2275	COG2854	intermembrane phospholipid transfer
A6A12_2276	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6A12_2277	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6A12_2278	COG1127	ABC transporter
A6A12_2280	COG0517	IMP dehydrogenase activity
A6A12_2280	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A6A12_2281	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A6A12_2283	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A6A12_2284	COG1137	ATPase activity
A6A12_2286	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A6A12_2287	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6A12_2289	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6A12_2290	COG2239	Acts as a magnesium transporter
A6A12_2291	COG0312	modulator of DNA gyrase
A6A12_2292	COG3028	Belongs to the UPF0307 family
A6A12_2293	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
A6A12_2294	COG1178	ABC-type Fe3 transport system permease component
A6A12_2295	COG4143	(ABC) transporter
A6A12_2296	COG0163	prenyltransferase activity
A6A12_2297	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6A12_2298	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A6A12_2299	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A6A12_2300	COG2105	PFAM AIG2 family protein
A6A12_2301	COG2911	Protein conserved in bacteria
A6A12_2302	COG0729	surface antigen
A6A12_2303	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6A12_2304	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
A6A12_2311	COG0529	Catalyzes the synthesis of activated sulfate
A6A12_2312	COG2895	sulfate adenylyltransferase (ATP) activity
A6A12_2313	COG0175	sulfate reduction
A6A12_2314	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6A12_2314	COG1648	precorrin-2 dehydrogenase activity
A6A12_2315	COG0737	Belongs to the 5'-nucleotidase family
A6A12_2323	COG0513	Belongs to the DEAD box helicase family
A6A12_2324	COG2153	protein acetylation
A6A12_2325	COG3266	domain, Protein
A6A12_2325	COG3061	Opacity-associated protein A
A6A12_2326	COG0545	Peptidyl-prolyl cis-trans isomerase
A6A12_2327	COG0203	ribosomal protein L17
A6A12_2329	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A6A12_2330	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A6A12_2331	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A6A12_2333	COG0201	protein transport
A6A12_2338	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A6A12_2339	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A6A12_2343	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A6A12_2344	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6A12_2349	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6A12_2354	COG0051	transcription antitermination factor activity, RNA binding
A6A12_2355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6A12_2356	COG0557	exoribonuclease II activity
A6A12_2358	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
A6A12_2360	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A6A12_2362	COG1047	Peptidyl-prolyl cis-trans
A6A12_2363	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
A6A12_2365	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6A12_2366	COG0488	(ABC) transporter
A6A12_2368	COG0429	hydrolase of the alpha beta-hydrolase fold
A6A12_2370	COG3954	Phosphoribulokinase
A6A12_2371	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6A12_2375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A6A12_2378	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6A12_2380	COG0583	DNA-binding transcription factor activity
A6A12_2383	COG0180	Tryptophanyl-tRNA synthetase
A6A12_2384	COG0546	phosphoglycolate phosphatase activity
A6A12_2385	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A6A12_2386	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A6A12_2389	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A6A12_2395	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A6A12_2397	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6A12_2397	COG0678	peroxiredoxin activity
A6A12_2398	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6A12_2400	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A6A12_2400	COG0165	Argininosuccinate lyase
A6A12_2402	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6A12_2403	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A6A12_2407	COG1045	serine acetyltransferase
A6A12_2408	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A6A12_2410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6A12_2411	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A6A12_2412	COG1053	succinate dehydrogenase
A6A12_2413	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A6A12_2414	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
A6A12_2416	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6A12_2417	COG1509	lysine 2,3-aminomutase activity
A6A12_2421	COG0459	protein refolding
A6A12_2427	COG0149	triose-phosphate isomerase activity
A6A12_2428	COG0534	Mate efflux family protein
A6A12_2429	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A6A12_2430	COG1575	Belongs to the MenA family. Type 1 subfamily
A6A12_2434	COG1609	Transcriptional regulator
A6A12_2435	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6A12_2438	COG0281	malic enzyme
A6A12_2440	COG0626	cystathionine gamma-synthase activity
A6A12_2441	COG0460	homoserine dehydrogenase
A6A12_2441	COG0527	aspartate kinase activity
A6A12_2442	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A6A12_2443	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A6A12_2445	COG1494	fructose-1,6-bisphosphatase
A6A12_2446	COG0205	6-phosphofructokinase activity
A6A12_2447	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A6A12_2449	COG0745	RESPONSE REGULATOR receiver
A6A12_2450	COG2205	protein histidine kinase activity
A6A12_2451	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A6A12_2452	COG1278	Cold shock
A6A12_2453	COG3030	protein affecting phage T7 exclusion by the F plasmid
A6A12_2455	COG1027	Aspartate ammonia-lyase
A6A12_2456	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A6A12_2457	COG1288	antiporter activity
A6A12_2459	COG0549	Belongs to the carbamate kinase family
A6A12_2460	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6A12_2461	COG0540	Belongs to the ATCase OTCase family
A6A12_2462	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
A6A12_2464	COG1438	arginine binding
A6A12_2465	COG4232	protein-disulfide reductase activity
A6A12_2467	COG3263	regulation of cellular component size
A6A12_2469	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6A12_2470	COG0784	Response regulator, receiver
A6A12_2470	COG2198	Histidine kinase
A6A12_2470	COG2205	protein histidine kinase activity
A6A12_2471	COG2814	Major facilitator Superfamily
A6A12_2474	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6A12_2475	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A6A12_2476	COG0511	ligase activity, forming carbon-carbon bonds
A6A12_2477	COG0439	Biotin carboxylase
A6A12_2478	COG2264	protein methyltransferase activity
A6A12_2480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6A12_2481	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
A6A12_2483	COG0840	transmembrane signaling receptor activity
A6A12_2484	COG0840	transmembrane signaling receptor activity
A6A12_2485	COG0789	Transcriptional regulator
A6A12_2487	COG0151	Belongs to the GarS family
A6A12_2489	COG0776	regulation of translation
A6A12_2490	COG1253	flavin adenine dinucleotide binding
A6A12_2491	COG2852	Protein conserved in bacteria
A6A12_2492	COG3068	Protein conserved in bacteria
A6A12_2494	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6A12_2495	COG0668	transmembrane transport
A6A12_2497	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A6A12_2499	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6A12_2502	COG0438	transferase activity, transferring glycosyl groups
A6A12_2509	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6A12_2510	COG1596	polysaccharide export
A6A12_2515	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6A12_2517	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6A12_2522	COG3754	Rhamnan synthesis protein F
A6A12_2528	COG0463	Glycosyl transferase, family 2
A6A12_2529	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6A12_2531	COG0028	Belongs to the TPP enzyme family
A6A12_2534	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A6A12_2538	COG5433	transposase activity
A6A12_2539	COG5433	transposase activity
A6A12_2542	COG1682	transport, permease protein
A6A12_2547	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6A12_2549	COG3307	-O-antigen
A6A12_2550	COG0859	PFAM glycosyl transferase family 9
A6A12_2553	COG1519	Transferase
A6A12_2555	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6A12_2558	COG3642	lipopolysaccharide core region biosynthetic process
A6A12_2559	COG0859	PFAM glycosyl transferase family 9
A6A12_2560	COG0463	Glycosyl transferase, family 2
A6A12_2561	COG0859	PFAM glycosyl transferase family 9
A6A12_2562	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A6A12_2563	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A6A12_2565	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6A12_2568	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6A12_2569	COG1309	transcriptional regulator
A6A12_2570	COG1560	Kdo2-lipid A biosynthetic process
A6A12_2571	COG1560	Kdo2-lipid A biosynthetic process
A6A12_2573	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A6A12_2574	COG1561	YicC-like family, N-terminal region
A6A12_2591	COG2433	Pfam Transposase IS66
A6A12_2597	COG2801	Transposase and inactivated derivatives
A6A12_2598	COG2433	Pfam Transposase IS66
A6A12_2602	COG2963	transposase activity
A6A12_2605	COG0612	Peptidase, M16
A6A12_2611	COG1120	ATPase activity
A6A12_2612	COG4774	siderophore transport
A6A12_2613	COG1132	(ABC) transporter
A6A12_2614	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6A12_2614	COG1263	PTS System
A6A12_2615	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A6A12_2619	COG0514	ATP-dependent DNA helicase (RecQ)
A6A12_2620	COG2962	Rard protein
A6A12_2622	COG1280	lysine exporter protein (LysE YggA)
A6A12_2623	COG0210	DNA helicase
A6A12_2624	COG0339	signal peptide processing
A6A12_2625	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A6A12_2626	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6A12_2633	COG5290	Psort location Cytoplasmic, score
A6A12_2635	COG2433	Pfam Transposase IS66
A6A12_2640	COG3081	Nucleoid-associated protein
A6A12_2644	COG2433	Pfam Transposase IS66
A6A12_2656	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6A12_2670	COG1309	transcriptional regulator
A6A12_2671	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6A12_2672	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6A12_2673	COG2960	long-chain fatty acid transporting porin activity
A6A12_2675	COG0583	DNA-binding transcription factor activity
A6A12_2676	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6A12_2681	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A6A12_2682	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6A12_2682	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6A12_2685	COG0084	hydrolase, TatD family'
A6A12_2686	COG0805	protein transport
A6A12_2687	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6A12_2689	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6A12_2692	COG1322	Protein conserved in bacteria
A6A12_2696	COG2160	L-arabinose isomerase activity
A6A12_2698	COG1069	ribulokinase activity
A6A12_2699	COG1879	ABC-type sugar transport system periplasmic component
A6A12_2700	COG1129	ABC transporter
A6A12_2701	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6A12_2704	COG2081	HI0933 family
A6A12_2707	COG1528	Iron-storage protein
A6A12_2708	COG0589	response to stress
A6A12_2709	COG0697	spore germination
A6A12_2711	COG0742	ribosomal rna small subunit methyltransferase
A6A12_2712	COG1522	sequence-specific DNA binding
A6A12_2717	COG0006	proline dipeptidase activity
A6A12_2717	COG0006	proline dipeptidase activity
A6A12_2718	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6A12_2720	COG2104	thiamine diphosphate biosynthetic process
A6A12_2722	COG0352	thiamine-phosphate diphosphorylase activity
A6A12_2736	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
A6A12_2737	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6A12_2738	COG1739	Uncharacterized protein family UPF0029
A6A12_2740	COG0183	Belongs to the thiolase family
A6A12_2741	COG0583	DNA-binding transcription factor activity
A6A12_2742	COG2814	Major facilitator Superfamily
A6A12_2744	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6A12_2745	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A6A12_2746	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6A12_2747	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6A12_2748	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6A12_2749	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6A12_2751	COG0356	it plays a direct role in the translocation of protons across the membrane
A6A12_2752	COG3312	ion transport
A6A12_2753	COG1475	DNA binding
A6A12_2754	COG1192	Involved in chromosome partitioning
A6A12_2756	COG0445	tRNA wobble uridine modification
A6A12_2757	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A6A12_2759	COG0706	membrane insertase activity
A6A12_2762	COG1126	abc transporter atp-binding protein
A6A12_2766	COG0592	DNA-directed DNA polymerase activity
A6A12_2767	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6A12_2768	COG0187	DNA topoisomerase II activity
A6A12_2771	COG0071	Belongs to the small heat shock protein (HSP20) family
A6A12_2772	COG3977	Valine--pyruvate aminotransferase
A6A12_2774	COG0752	glycyl-tRNA synthetase alpha subunit
A6A12_2775	COG2119	membrane
A6A12_2781	COG0604	alcohol dehydrogenase
A6A12_2783	COG0129	dihydroxy-acid dehydratase activity
A6A12_2784	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6A12_2785	COG3978	acetolactate synthase activity
A6A12_2787	COG0606	chelatase, subunit chli
A6A12_2801	COG2433	Pfam Transposase IS66
A6A12_2804	COG0606	chelatase, subunit chli
A6A12_2806	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6A12_2807	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A6A12_2809	COG3084	Protein conserved in bacteria
A6A12_2811	COG1272	protein, Hemolysin III
A6A12_2813	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6A12_2814	COG0569	domain protein
A6A12_2815	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6A12_2815	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6A12_2816	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A6A12_2818	COG1652	LysM domain
A6A12_2819	COG0758	DNA mediated transformation
A6A12_2820	COG2922	Belongs to the Smg family
A6A12_2821	COG0551	DNA topoisomerase type I activity
A6A12_2823	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A6A12_2824	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A6A12_2825	COG0009	L-threonylcarbamoyladenylate synthase
A6A12_2826	COG0408	coproporphyrinogen oxidase activity
A6A12_2827	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6A12_2829	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A6A12_2840	COG3071	HemY protein
A6A12_2841	COG2959	enzyme of heme biosynthesis
A6A12_2842	COG1587	Uroporphyrinogen-III synthase
A6A12_2844	COG3072	Adenylate cyclase
A6A12_2847	COG0019	diaminopimelate decarboxylase activity
A6A12_2850	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A6A12_2851	COG1011	Hydrolase
A6A12_2855	COG0561	phosphatase activity
A6A12_2856	COG2267	carboxylic ester hydrolase activity
A6A12_2857	COG1280	lysine exporter protein (LysE YggA)
A6A12_2858	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A6A12_2859	COG0783	Belongs to the Dps family
A6A12_2864	COG2095	MarC family integral membrane protein
A6A12_2866	COG2433	Pfam Transposase IS66
A6A12_2873	COG2095	MarC family integral membrane protein
A6A12_2875	COG0742	ribosomal rna small subunit methyltransferase
A6A12_2876	COG0552	protein localization to endoplasmic reticulum
A6A12_2877	COG2884	Cell division ATP-binding protein ftsE
A6A12_2878	COG2177	Part of the ABC transporter FtsEX involved in
A6A12_2879	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6A12_2881	COG0705	Rhomboid family
A6A12_2882	COG1580	Controls the rotational direction of flagella during chemotaxis
A6A12_2883	COG3161	chorismate lyase activity
A6A12_2885	COG2937	Belongs to the GPAT DAPAT family
A6A12_2888	COG0534	Mate efflux family protein
A6A12_2893	COG3250	beta-galactosidase activity
A6A12_2901	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A6A12_2908	COG3550	peptidyl-serine autophosphorylation
A6A12_2917	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A6A12_2929	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6A12_2930	COG3300	MHYT domain
A6A12_2930	COG5001	Diguanylate cyclase
A6A12_2933	COG3852	Histidine kinase
A6A12_2936	COG0174	glutamine synthetase
A6A12_2939	COG1490	D-aminoacyl-tRNA deacylase activity
A6A12_2940	COG0456	acetyltransferase
A6A12_2942	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A6A12_2944	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A6A12_2945	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A6A12_2946	COG3031	protein transport across the cell outer membrane
A6A12_2948	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6A12_2949	COG1459	type II secretion system
A6A12_2950	COG2165	general secretion pathway protein
A6A12_2951	COG2165	general secretion pathway protein
A6A12_2952	COG2165	general secretion pathway protein
A6A12_2953	COG4795	General secretion pathway protein
A6A12_2954	COG3156	type II secretion system protein K
A6A12_2955	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
A6A12_2956	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
A6A12_2959	COG1218	3'(2'),5'-bisphosphate nucleotidase
A6A12_2960	COG0494	nUDIX hydrolase
A6A12_2961	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A6A12_2961	COG0316	Belongs to the HesB IscA family
A6A12_2962	COG1040	competence protein
A6A12_2963	COG0596	Alpha beta hydrolase
A6A12_2965	COG2183	response to ionizing radiation
A6A12_2966	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6A12_2971	COG0583	DNA-binding transcription factor activity
A6A12_2976	COG0745	RESPONSE REGULATOR receiver
A6A12_2978	COG2233	PERMEase
A6A12_2979	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6A12_2980	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6A12_2981	COG1758	RNA polymerase activity
A6A12_2982	COG0194	GDP metabolic process
A6A12_2983	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A6A12_2984	COG0248	Ppx GppA phosphatase
A6A12_2986	COG3118	belongs to the thioredoxin family
A6A12_2987	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A6A12_2989	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A6A12_3002	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6A12_3005	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6A12_3006	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A6A12_3006	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A6A12_3007	COG1072	(Pantothenic acid kinase))