locus-tag class description VEA_000001 ENOG4107QZF nitrite reductase NADPH large subunit VEA_000004 ENOG4108IG5 Transcriptional regulator VEA_000007 ENOG4105F8J Adenylate Guanylate cyclase VEA_000011 ENOG4105D9P serine threonine protein kinase VEA_000015 ENOG4106VK6 Flagellar motor protein VEA_000018 ENOG4108ZF3 Phosphatase VEA_000027 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit VEA_000032 ENOG4107RFY SbcCD D subunit VEA_000033 ENOG4105EYH Exonuclease VEA_000035 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VEA_000036 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit VEA_000040 ENOG4105M4H endoribonuclease L-psp VEA_000042 ENOG4105QNF Outer membrane lipoprotein VEA_000044 ENOG4105CSX c4-dicarboxylate anaerobic carrier VEA_000045 ENOG4106RE7 Cytochrome VEA_000046 ENOG4105C5W Aldolase VEA_000048 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) VEA_000049 ENOG4105EV2 VWA domain protein interacting with AAA ATPase VEA_000050 ENOG4105CC0 LysR family Transcriptional regulator VEA_000051 ENOG4105CXG d-lactate dehydrogenase VEA_000054 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) VEA_000055 ENOG4108NVR Methyl-accepting chemotaxis VEA_000065 ENOG4105BZU Histidine kinase VEA_000067 ENOG4105NXH GreA GreB family elongation factor VEA_000068 ENOG4107QZF nitrite reductase NADPH large subunit VEA_000069 ENOG4105WZK nitrite reductase NADPH small subunit VEA_000071 ENOG4105TMB Formate nitrite transporter VEA_000072 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) VEA_000075 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter VEA_000081 ENOG4105VXR cytoplasmic protein VEA_000082 ENOG4108ISG Major Facilitator VEA_000083 ENOG4105K63 Thioredoxin VEA_000084 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) VEA_000088 ENOG4105EIP mannose-6-phosphate isomerase VEA_000089 ENOG4105CXY transporter VEA_000090 ENOG4105BZU Histidine kinase VEA_000091 ENOG4108KX4 response regulator VEA_000092 ENOG4105CXY transporter VEA_000093 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) VEA_000094 ENOG4105C5Q Transcriptional regulator VEA_000095 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit VEA_000097 ENOG4107TIF Phenazine biosynthesis protein, PhzF family VEA_000104 ENOG4105BZS acriflavin resistance protein VEA_000107 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase VEA_000108 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) VEA_000109 ENOG4105UQX Mate efflux family protein VEA_000110 ENOG4108K01 transcriptional regulator VEA_000111 ENOG4105CGF Aromatic amino acid aminotransferase VEA_000112 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) VEA_000115 ENOG4105WXI Bacterial OB fold (BOF) protein VEA_000116 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) VEA_000117 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein VEA_000118 ENOG4105E0C molybdate abc transporter VEA_000119 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) VEA_000123 ENOG4105BZU Histidine kinase VEA_000126 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) VEA_000127 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) VEA_000133 ENOG4108M6U Universal stress protein A VEA_000135 ENOG4105EJC lysr family transcriptional regulator VEA_000152 ENOG4108ZJT translation initiation factor, Sui1 VEA_000154 ENOG4105CPF Cell wall formation (By similarity) VEA_000156 ENOG4105CD5 CoA-binding domain protein VEA_000157 ENOG4105CWB LysR family transcriptional Regulator VEA_000160 ENOG4105CMR udp-glucose 4-epimerase VEA_000161 ENOG4105BZU Histidine kinase VEA_000162 ENOG4105E7W lamb ycsf family protein VEA_000163 ENOG4105P4J Allophanate hydrolase, subunit 1 VEA_000166 ENOG4105CV6 ABC transporter, permease VEA_000167 ENOG4108I0Y (ABC) transporter VEA_000169 ENOG4105RKW reductase (By VEA_000178 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) VEA_000180 ENOG4105KA0 thioesterase Superfamily protein VEA_000183 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation VEA_000184 ENOG4108M0H Extracellular lipase VEA_000188 ENOG4105DU1 integral membrane protein, terc VEA_000189 ENOG4105CGH 5'-nucleotidase VEA_000190 ENOG4105CPB ATP-dependent endonuclease of the OLD family VEA_000191 ENOG4108UQ5 membrane protein YcdZ VEA_000192 ENOG4105DUM transcriptional regulator, lysR family VEA_000193 ENOG4105TMB Formate nitrite transporter VEA_000194 ENOG4108YYC ycei family VEA_000195 ENOG4105DS1 cytochrome b561 VEA_000198 ENOG4108M8H domain protein VEA_000199 ENOG4105C1J atp-dependent rna helicase VEA_000200 ENOG4108ZYK Acyl carrier protein phosphodiesterase VEA_000202 ENOG4108N3W hemolysin secretion protein VEA_000204 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) VEA_000207 ENOG4107RE1 Inosine-guanosine kinase VEA_000208 ENOG4105CKU formyltetrahydrofolate synthetase VEA_000209 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) VEA_000211 ENOG4105CF7 AraC family transcriptional regulator VEA_000212 ENOG4108I6A alcohol dehydrogenase VEA_000214 ENOG4105CDA abc transporter atp-binding protein VEA_000215 ENOG4105E5Q amino acid AbC transporter VEA_000216 ENOG4106TNF Periplasmic binding protein VEA_000217 ENOG4105DRP amino acid AbC transporter VEA_000218 ENOG4108NJZ Sensory box GGDEF EAL domain protein VEA_000221 ENOG4107B7Y DNA-binding transcriptional regulator FruR VEA_000222 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein VEA_000223 ENOG4105DE4 1-phosphofructokinase VEA_000224 ENOG4105DM4 PTS System VEA_000228 ENOG4105DJY efflux transporter, rnd family, mfp subunit VEA_000230 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) VEA_000232 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) VEA_000233 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) VEA_000234 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor VEA_000235 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase VEA_000236 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) VEA_000241 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) VEA_000246 ENOG4105HDD phospholipase VEA_000249 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) VEA_000256 ENOG4105CJW magnesium transporter VEA_000260 ENOG4108UYE Lactoylglutathione lyase VEA_000261 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase VEA_000266 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) VEA_000267 ENOG4105CBC glutamate synthase VEA_000269 ENOG4107RGH Aldehyde dehydrogenase VEA_000272 ENOG4108I0N Transporter, RarD family, DMT superfamily protein VEA_000273 ENOG4105KPY Small multidrug resistance protein VEA_000278 ENOG4105FR1 rard protein VEA_000280 ENOG4108VAU general secretion pathway protein G VEA_000281 ENOG4107R88 Chemotaxis protein (CheV) VEA_000282 ENOG4108WQH regulatoR VEA_000284 ENOG4105BZU Histidine kinase VEA_000286 ENOG4105BZU Histidine kinase VEA_000287 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) VEA_000288 ENOG4107KBT 8-Amino-7-oxononanoate synthase VEA_000289 ENOG4108MGY Histidine kinase VEA_000293 ENOG4105CEE C4-dicarboxylate transporter VEA_000294 ENOG4108V0P LemA family VEA_000295 ENOG4105D0M Protease HtpX homolog VEA_000298 ENOG4105F2V VRR-NUC domain-containing protein VEA_000300 ENOG4108YDI single-species biofilm formation on inanimate substrate VEA_000301 ENOG4107TE5 Lipid kinase VEA_000302 ENOG41064T2 transcriptional regulator, lysR family VEA_000303 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) VEA_000309 ENOG4105C7R Atpase associated with various cellular activities aaa_3 VEA_000310 ENOG4105C4X radical SAM domain protein VEA_000311 ENOG41061MV Arylsulfatase VEA_000313 ENOG4105ENH Sulfatase VEA_000317 ENOG4105BZU Histidine kinase VEA_000318 ENOG4108SV3 Tmao reductase system periplasmic protein tort VEA_000319 ENOG4108Z5K methylglyoxal synthase VEA_000320 ENOG41088T4 Helicase IV VEA_000321 ENOG4105EM2 membrane VEA_000327 ENOG4108W3Q Transcriptional regulator VEA_000328 ENOG4108Z6Z Transcriptional regulator VEA_000329 ENOG4108IPW abc transporter atp-binding protein VEA_000330 ENOG4105CM4 permease protein VEA_000331 ENOG4105DHS permease protein VEA_000334 ENOG4108I5U Uridine phosphorylase VEA_000335 ENOG4106Z1T Nicotinamide Mononucleotide Transporter VEA_000337 ENOG4105ETE Transcriptional regulator (LacI family VEA_000338 ENOG4108RVA ribokinase VEA_000339 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator VEA_000340 ENOG4105CNN ABC, transporter VEA_000341 ENOG4105C2J ABC transporter VEA_000342 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) VEA_000343 ENOG4108K0B C-di-gmp phosphodiesterase VEA_000352 ENOG4105D82 Glutamate dehydrogenase VEA_000354 ENOG4105BZU Histidine kinase VEA_000355 ENOG4105CA0 peroxidase VEA_000356 ENOG4105BZU Histidine kinase VEA_000358 ENOG4107QX8 SPFH domain, Band 7 family protein VEA_000360 ENOG4108RCM Nitroreductase VEA_000361 ENOG4108IJ7 Glycine betaine VEA_000362 ENOG4108HQS Glycine betaine VEA_000364 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) VEA_000365 ENOG4105C26 Dehydrogenase VEA_000366 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) VEA_000368 ENOG4105BZU Histidine kinase VEA_000369 ENOG4105CHR reductase VEA_000370 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase VEA_000372 ENOG4105E39 Enoyl-CoA hydratase VEA_000373 ENOG4105C1G acyl-Coa dehydrogenase VEA_000374 ENOG4105C26 Dehydrogenase VEA_000375 ENOG4105CHU acetyl-coa acetyltransferase VEA_000377 ENOG4105C1G acyl-Coa dehydrogenase VEA_000378 ENOG4107QX3 carboxylase VEA_000379 ENOG4108IPT Naphthoate synthase VEA_000380 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase VEA_000381 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase VEA_000382 ENOG4105BZU Histidine kinase VEA_000386 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family VEA_000387 ENOG4105C4M (Ubiquinol oxidase) subunit I VEA_000388 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii VEA_000390 ENOG4108S58 Phenazine biosynthesis protein PhzF VEA_000391 ENOG4107YBY Hydrolase VEA_000393 ENOG4107FQX Alpha-acetolactate decarboxylase VEA_000394 ENOG4105C7K acetolactate synthase VEA_000395 ENOG4105CHR reductase VEA_000396 ENOG4105C94 Transporter VEA_000398 ENOG4105DZS Phenylacetate-CoA ligase VEA_000399 ENOG4108IV0 ABC, transporter VEA_000404 ENOG4105C0Z ABC transporter VEA_000406 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase VEA_000407 ENOG4105BZJ Electron transfer flavoprotein VEA_000408 ENOG4105C10 Electron transfer flavoprotein VEA_000409 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) VEA_000410 ENOG4105CI1 PTS System VEA_000411 ENOG4105F8D glycoside hydrolase family 4 VEA_000412 ENOG4105FDP GntR family transcriptional regulator VEA_000413 ENOG4105KJM monovalent cation h antiporter subunit g VEA_000414 ENOG41080TA Multiple resistance and ph regulation protein f VEA_000415 ENOG4105SC1 monovalent cation H antiporter subunit E VEA_000416 ENOG4108JPZ Monovalent cation H antiporter subunit D VEA_000417 ENOG4105MKQ Monovalent cation H antiporter subunit C VEA_000418 ENOG4105D65 subunit l VEA_000419 ENOG4105Q9Y Universal stress protein VEA_000420 ENOG4105EMU Dehydrogenase VEA_000421 ENOG4105CC0 LysR family Transcriptional regulator VEA_000423 ENOG4105C2C drug resistance transporter, Bcr CflA VEA_000424 ENOG4105ENX hydrolase VEA_000427 ENOG4105NVB glycoside hydrolase, family 19 VEA_000436 ENOG4105EW9 transcriptional regulator AsnC family VEA_000443 ENOG4105D9P serine threonine protein kinase VEA_000448 ENOG4105CS6 Rhs element vgr protein VEA_000449 ENOG4108WC9 type VI secretion system effector, hcp1 family VEA_000450 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit VEA_000451 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VEA_000452 ENOG4105KCK Peptidoglycan-associated lipoprotein VEA_000457 ENOG4105DR5 peptidase VEA_000459 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein VEA_000460 ENOG4105DQU oxidoreductase, subunit beta VEA_000463 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family VEA_000470 ENOG4107QHE Choloylglycine hydrolase VEA_000471 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) VEA_000472 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) VEA_000474 ENOG4108UNF response regulator VEA_000475 ENOG4107RGM aldo keto reductase VEA_000478 ENOG4105CMQ Chloride channel VEA_000480 ENOG4105C5A transporter VEA_000481 ENOG4105EUJ GTP cyclohydrolase i VEA_000482 ENOG4105CVM Molybdenum cofactor synthesis domain protein VEA_000483 ENOG4105D06 uba thif-type nad fad binding protein VEA_000488 ENOG4105KHC sulfurtransferase VEA_000489 ENOG4105BZU Histidine kinase VEA_000494 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) VEA_000495 ENOG4105CV1 Transketolase (EC 2.2.1.1) VEA_000496 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor VEA_000497 ENOG4105DXI Major Facilitator superfamily VEA_000498 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) VEA_000499 ENOG4105UYK outer membrane protein a VEA_000500 ENOG4107VXZ Hydrolase VEA_000501 ENOG4108YZN class I peptide chain release factor VEA_000502 ENOG4105C8Q Methyl-accepting chemotaxis VEA_000505 ENOG4107YWA deoxycytidylate deaminase VEA_000506 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) VEA_000509 ENOG4105WH1 Two component transcriptional regulator luxr family VEA_000510 ENOG4105BZU Histidine kinase VEA_000513 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) VEA_000517 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class VEA_000519 ENOG4105CHU acetyl-coa acetyltransferase VEA_000523 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) VEA_000524 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) VEA_000530 ENOG4105EW9 transcriptional regulator AsnC family VEA_000534 ENOG4105J12 Multidrug resistance protein mdtN VEA_000536 ENOG4105BZU Histidine kinase VEA_000537 ENOG4108QGH periplasmic VEA_000538 ENOG41082IR Excinuclease ABC C subunit domain protein VEA_000539 ENOG4108YXG UPF0502 protein VEA_000542 ENOG41090HJ UPF0265 protein VEA_000544 ENOG4105BZU Histidine kinase VEA_000551 ENOG4105DUM transcriptional regulator, lysR family VEA_000553 ENOG4105DVH amino acid VEA_000556 ENOG4105E0F Histidine kinase VEA_000557 ENOG4105CK6 Two component transcriptional regulator (Winged helix family VEA_000563 ENOG4105EFX secretion protein, HlyD family VEA_000564 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) VEA_000565 ENOG4105CJW magnesium transporter VEA_000566 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin VEA_000567 ENOG4105DZC cytosine deaminase VEA_000568 ENOG4105EST Metal Dependent Phosphohydrolase VEA_000570 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) VEA_000572 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) VEA_000576 ENOG4108Z33 Thiol disulfide Interchange Protein VEA_000579 ENOG4107EXC regulatoR VEA_000580 ENOG4105E0F Histidine kinase VEA_000582 ENOG41080IJ Diacylglycerol kinase VEA_000583 ENOG4105DIJ Phosphoethanolamine transferase VEA_000584 ENOG4105EP9 oxidoreductase VEA_000588 ENOG4108NRW Phospholipase, patatin family VEA_000589 ENOG4105EUB pirin domain protein VEA_000590 ENOG4105VEQ Cold shock protein VEA_000592 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) VEA_000593 ENOG4105EHV domain protein VEA_000595 ENOG4105DZ1 carboxypeptidase VEA_000596 ENOG4105CYM Glutathione S-transferase VEA_000597 ENOG4108HKT sucrose-6-phosphate hydrolase VEA_000598 ENOG4105D7K pfkb domain protein VEA_000599 ENOG4105C5Y PTS System VEA_000603 ENOG4105CHR reductase VEA_000606 ENOG4108P3C VEA_000611 ENOG410874W AraC family transcriptional regulator VEA_000612 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family VEA_000619 ENOG4105C1J atp-dependent rna helicase VEA_000621 ENOG4107RSM transcriptional regulator VEA_000624 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase VEA_000625 ENOG4105CPQ Dehydrogenase VEA_000627 ENOG4105CHR reductase VEA_000628 ENOG4108NKV transcriptional regulator VEA_000629 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VEA_000630 ENOG4108K1J Transporter DctQ VEA_000631 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family VEA_000632 ENOG4105ENR peptidase, M24 VEA_000633 ENOG4105E5N succinylglutamate desuccinylase aspartoacylase VEA_000634 ENOG4108KJ1 Trap dicarboxylate transporter, dctp subunit VEA_000635 ENOG4108RYR transcriptional regulator AsnC family VEA_000636 ENOG4105C26 Dehydrogenase VEA_000637 ENOG4105C8Y Acetylornithine aminotransferase VEA_000641 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme VEA_000642 ENOG4105N14 lysine exporter protein LysE YggA VEA_000645 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis VEA_000646 ENOG4105HDK L-asparaginase VEA_000647 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) VEA_000650 ENOG4105WH1 Two component transcriptional regulator luxr family VEA_000651 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) VEA_000654 ENOG4107KET secretion protein, HlyD family VEA_000661 ENOG4105CY5 solute-binding protein VEA_000665 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) VEA_000670 ENOG4107RZC phospholipase d VEA_000675 ENOG4108Z4X TRANSCRIPTIONal VEA_000677 ENOG4105RQF LysR family Transcriptional regulator VEA_000679 ENOG4107S8C mandelate racemase muconate lactonizing VEA_000680 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) VEA_000685 ENOG4105VYW UPF0251 protein VEA_000686 ENOG4107U14 binding-protein-dependent transport systems inner membrane Component VEA_000687 ENOG4108IJ7 Glycine betaine VEA_000689 ENOG4105RW8 MltA-interacting MipA family protein VEA_000692 ENOG4105ETT transcriptional Regulator, LysR family VEA_000697 ENOG4107RH7 Nicotinate phosphoribosyltransferase VEA_000699 ENOG4108RWI nicotinamidase VEA_000701 ENOG4105N2W Transcriptional regulator VEA_000702 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase VEA_000703 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) VEA_000705 ENOG4105DM4 PTS System VEA_000706 ENOG4105CWX Alpha-1,2-mannosidase VEA_000707 ENOG4105CWX Alpha-1,2-mannosidase VEA_000709 ENOG4105CWX Alpha-1,2-mannosidase VEA_000710 ENOG4105CWX Alpha-1,2-mannosidase VEA_000711 ENOG4105EA8 2-Nitropropane dioxygenase VEA_000712 ENOG4105CUB amino acid VEA_000713 ENOG4107FQ9 ethanolamine ammonia-lyase VEA_000714 ENOG4105CPD ethanolamine ammonia-lyase VEA_000715 ENOG4108K3Z AraC family transcriptional regulator VEA_000716 ENOG4107Z3H Transcriptional regulator, TetR family VEA_000722 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) VEA_000723 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) VEA_000724 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) VEA_000726 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) VEA_000730 ENOG4105DTJ flagellar hook-associated protein VEA_000731 ENOG4105E1Q flagellar hook-associated protein VEA_000732 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj VEA_000733 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) VEA_000734 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) VEA_000735 ENOG4105CGA flagellar basal-body rod protein FlgG VEA_000736 ENOG4108KPB Flagellar basal-body rod protein FlgF VEA_000737 ENOG4105BZE flagellar hook protein, FlgE VEA_000738 ENOG4105W00 Flagellar hook capping protein VEA_000739 ENOG4108ZC9 flagellar basal-body rod protein flgc VEA_000740 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) VEA_000744 ENOG4105E4C Lytic transglycosylase catalytic VEA_000745 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) VEA_000749 ENOG4105EJQ L-serine dehydratase VEA_000750 ENOG4105DUX Transporter VEA_000754 ENOG4105ETT transcriptional Regulator, LysR family VEA_000757 ENOG4105CJP fad dependent oxidoreductase VEA_000760 ENOG4108MJ5 VirK protein VEA_000764 ENOG4107RCV ABC transporter, permease VEA_000767 ENOG4107STF Involved in phosphonate degradation (By similarity) VEA_000768 ENOG4108JPW Aminotransferase VEA_000769 ENOG4108KAZ Involved in phosphonate degradation (By similarity) VEA_000770 ENOG4105ETE Transcriptional regulator (LacI family VEA_000775 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin VEA_000776 ENOG4105KUU lipolytic protein G-D-S-L family VEA_000778 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation VEA_000779 ENOG4108UHE carbonic anhydrase VEA_000780 ENOG4108UUE Transcriptional regulator VEA_000783 ENOG4105PAD Hydrolase VEA_000784 ENOG4105JQN Transcriptional regulator VEA_000791 ENOG4108UW5 maltose o-acetyltransferase VEA_000792 ENOG4108UKZ OsmC family VEA_000793 ENOG4105E0X reductase VEA_000795 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein VEA_000796 ENOG4105CVP deoxyribo-dipyrimidine photolyase VEA_000797 ENOG4106TD9 Diguanylate cyclase VEA_000800 ENOG4105BZU Histidine kinase VEA_000803 ENOG4105D9N nucleoside VEA_000805 ENOG4105C0F tryptophanase EC 4.1.99.1 VEA_000806 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) VEA_000807 ENOG4105C4M (Ubiquinol oxidase) subunit I VEA_000808 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii VEA_000810 ENOG4105D5U fad dependent oxidoreductase VEA_000813 ENOG4105CWM branched-chain amino acid transport system II carrier protein VEA_000814 ENOG4106TD9 Diguanylate cyclase VEA_000815 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VEA_000824 ENOG4105DUM transcriptional regulator, lysR family VEA_000825 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) VEA_000826 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) VEA_000828 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) VEA_000829 ENOG4105CYW agmatinase VEA_000830 ENOG4105E5M Multidrug resistance protein D VEA_000831 ENOG4105CUG Oligopeptidase b VEA_000834 ENOG4105CC5 ABC transporter VEA_000835 ENOG4105DIK (ABC) transporter VEA_000836 ENOG4105DSE periplasmic solute binding protein VEA_000845 ENOG4109015 Biopolymer transport protein exbD tolR VEA_000850 ENOG4105JJR Histidine kinase VEA_000851 ENOG4105E3W Two component transcriptional regulator (Winged helix family VEA_000852 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) VEA_000853 ENOG4107VXM glycerophosphoryl diester phosphodiesterase VEA_000855 ENOG4105C5I Dehydrogenase VEA_000856 ENOG4108YYI Protein of unknown function (DUF2810) VEA_000860 ENOG4108TEM pseudouridine methyltransferase VEA_000863 ENOG4105DWF phosphomethylpyrimidine kinase VEA_000864 ENOG4108YI8 ABC transporter VEA_000865 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component VEA_000866 ENOG4107Z6I Thiamine biosynthesis protein VEA_000867 ENOG4105ETU transcriptional activator (TenA VEA_000868 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase VEA_000869 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) VEA_000871 ENOG4107QY8 reductase VEA_000872 ENOG4105CUW cytochrome C-TYPE protein VEA_000873 ENOG41068WN VEA_000874 ENOG4105CYX Short-chain dehydrogenase reductase Sdr VEA_000881 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family VEA_000882 ENOG4105BZW Glycerate kinase VEA_000883 ENOG4105C6Z Gluconate VEA_000884 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR VEA_000889 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 VEA_000894 ENOG4108WAV Transcriptional regulator VEA_000895 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase VEA_000896 ENOG4108UVJ appr-1-p processing domain protein VEA_000897 ENOG4107WCA isomerase VEA_000901 ENOG4105C0R drug resistance transporter emrb qaca subfamily VEA_000903 ENOG4105EIF outer membrane protein W VEA_000904 ENOG4107W31 Pentapeptide repeat protein VEA_000907 ENOG4108M1A Chitin-binding protein VEA_000908 ENOG4108ZRZ Transcriptional regulator (AsnC family) VEA_000911 ENOG4105Q26 Siderophore-interacting protein VEA_000912 ENOG4105CAZ oligogalacturonide lyase VEA_000917 ENOG4108UHU Aldolase VEA_000918 ENOG4107SS6 2-dehydro-3-deoxygluconokinase VEA_000921 ENOG4105M5J Cupin 2, conserved barrel domain protein VEA_000922 ENOG4105P66 Membrane VEA_000923 ENOG4105CHR reductase VEA_000924 ENOG4105J4Q Transcriptional regulator VEA_000927 ENOG4105CC0 LysR family Transcriptional regulator VEA_000928 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase VEA_000930 ENOG4105C4W S-formylglutathione hydrolase VEA_000932 ENOG4108KHX Diguanylate cyclase VEA_000934 ENOG4108HCJ Hydrolase VEA_000935 ENOG4105EJC lysr family transcriptional regulator VEA_000939 ENOG4105D3G Pseudouridine synthase VEA_000940 ENOG4105UQX Mate efflux family protein VEA_000941 ENOG4105BZU Histidine kinase VEA_000943 ENOG4105NBK UPF0345 protein VEA_000946 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) VEA_000950 ENOG4105DN9 Na H antiporter VEA_000954 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) VEA_000955 ENOG4105D03 DNA-3-methyladenine glycosylase II VEA_000957 ENOG4108VGI doxx family VEA_000958 ENOG4105C2I pirin domain protein VEA_000962 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) VEA_000964 ENOG4105D6U Sodium Glutamate Symporter VEA_000965 ENOG4107U9B transcriptional regulator VEA_000966 ENOG4105CZV ABC transporter VEA_000968 ENOG4105D6U Sodium Glutamate Symporter VEA_000971 ENOG4105C8Q Methyl-accepting chemotaxis VEA_000972 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) VEA_000974 ENOG4108VAC response regulator VEA_000975 ENOG4108HRK Histidine kinase VEA_000979 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) VEA_000981 ENOG4105CNI cell division protein FtsW VEA_000982 ENOG4105CDY transcriptional regulatory protein VEA_000984 ENOG4105BZU Histidine kinase VEA_000989 ENOG4108JQ7 (ABC) transporter VEA_000995 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) VEA_000998 ENOG4105EQ2 LysR family Transcriptional regulator VEA_000999 ENOG4105FCK Membrane VEA_001000 ENOG4105C5Y PTS System VEA_001001 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate VEA_001002 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) VEA_001004 ENOG4108J59 Extracellular solute-binding protein, family 5 VEA_001008 ENOG4108JJA ABC, transporter VEA_001011 ENOG4107QZV Type I secretion membrane fusion protein VEA_001012 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VEA_001013 ENOG4105CQZ Histidine kinase VEA_001014 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) VEA_001017 ENOG4105C26 Dehydrogenase VEA_001019 ENOG4105CK7 Sodium proline symporter VEA_001022 ENOG4105KNA -acetyltransferase VEA_001024 ENOG4105EW9 transcriptional regulator AsnC family VEA_001027 ENOG4105BZ1 (ABC) transporter VEA_001029 ENOG4105CF7 AraC family transcriptional regulator VEA_001034 ENOG4108RPX mosc domain containing protein VEA_001038 ENOG4108AEY RNA polymerase sigma factor VEA_001039 ENOG4105ECQ AraC Family Transcriptional Regulator VEA_001040 ENOG4105EXG Transcriptional regulator VEA_001043 ENOG4108JU3 Alkyl hydroperoxide reductase VEA_001044 ENOG4105D3R alkyl hydroperoxide reductase VEA_001045 ENOG4105K56 Transcriptional regulator VEA_001046 ENOG4108ZHJ Organic hydroperoxide resistance protein VEA_001050 ENOG4105C19 ABC transporter VEA_001053 ENOG4105CKK Glycosyl transferase, family 2 VEA_001055 ENOG4106371 Methyltransferase VEA_001058 ENOG4105CI1 PTS System VEA_001059 ENOG4105DPZ Two component transcriptional regulator (Winged helix family VEA_001060 ENOG4105DHQ Histidine kinase VEA_001061 ENOG4108JP0 extracellular solute-binding protein family 1 VEA_001062 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) VEA_001063 ENOG4105DBM Siderophore biosynthesis protein VEA_001064 ENOG4105C6X Major Facilitator VEA_001065 ENOG4105DUU IucA IucC family protein VEA_001067 ENOG4105E0K tonB-dependent siderophore receptor VEA_001068 ENOG4105GAV receptor VEA_001069 ENOG4108HUF Transporter VEA_001070 ENOG4105DQ5 transport system permease protein VEA_001071 ENOG4108U1V ABC transporter, permease VEA_001072 ENOG4105E0A ABC, transporter VEA_001073 ENOG4105C8Q Methyl-accepting chemotaxis VEA_001074 ENOG4107RAN Peptidase, M16 VEA_001076 ENOG4105DR5 peptidase VEA_001084 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) VEA_001088 ENOG4108K8S endonuclease I VEA_001092 ENOG4105CXN decarboxylase VEA_001093 ENOG4105D5Q Arginine ornithine antiporter VEA_001095 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) VEA_001096 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) VEA_001097 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) VEA_001102 ENOG41061ZR Transcriptional regulator VEA_001103 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) VEA_001104 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) VEA_001105 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) VEA_001106 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase VEA_001107 ENOG4107T9C Alpha amylase catalytic region VEA_001110 ENOG41074DU domain protein VEA_001111 ENOG4108P2H Inner membrane protein YjiG VEA_001112 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) VEA_001114 ENOG4105CK2 sodium dicarboxylate symporter VEA_001118 ENOG4105KJF protein tyrosine phosphatase VEA_001119 ENOG4105DAY polysaccharide export protein VEA_001122 ENOG41081FY multiple antibiotic resistance (MarC)-related VEA_001123 ENOG4108NRW Phospholipase, patatin family VEA_001124 ENOG4108M1A Chitin-binding protein VEA_001126 ENOG4105CVP deoxyribo-dipyrimidine photolyase VEA_001128 ENOG4105C72 UPF0176 protein VEA_001131 ENOG4105DZ1 carboxypeptidase VEA_001133 ENOG4108ZX5 transcriptional regulator VEA_001134 ENOG4108RCM Nitroreductase VEA_001136 ENOG4105ETT transcriptional Regulator, LysR family VEA_001137 ENOG4105VYA Uncharacterized conserved protein (DUF2132) VEA_001139 ENOG4105DP0 ferredoxin-NADP reductase VEA_001140 ENOG41068P6 UPF0319 protein VEA_001141 ENOG4105IPI Membrane VEA_001143 ENOG4105Y49 secretion protein, HlyD family VEA_001149 ENOG4105G2Y Transcriptional regulator VEA_001150 ENOG4105CNH Multidrug resistance protein MdtL VEA_001152 ENOG4105I4A GCN5-related N-acetyltransferase VEA_001154 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) VEA_001155 ENOG4105F1A Pyruvate formate-lyase VEA_001156 ENOG4105C6N Formate acetyltransferase VEA_001163 ENOG4105KWG Pfam:DUF1696 VEA_001165 ENOG4105ER2 Ompa motb domain protein VEA_001166 ENOG4107RD7 Flagellar Motor Protein, MotA VEA_001171 ENOG4105MQ3 flagellar protein FliS VEA_001172 ENOG410804A Flagellar hook-associated 2 domain-containing protein VEA_001174 ENOG4105I03 Flagellin VEA_001177 ENOG4105D00 flagellar biosynthetic protein flhB VEA_001178 ENOG4105D19 Role in flagellar biosynthesis (By similarity) VEA_001179 ENOG4105VS8 Flagellar biosynthetic protein fliq VEA_001180 ENOG4105CN7 Flagellar biosynthetic protein FliP VEA_001181 ENOG4105DD5 Flagellar motor switch protein VEA_001184 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VEA_001186 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) VEA_001187 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) VEA_001189 ENOG4108JIR Flagellum-specific ATP synthase VEA_001195 ENOG4107SSZ Phosphatase VEA_001198 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase VEA_001199 ENOG4105EXG Transcriptional regulator VEA_001205 ENOG4105DPZ Two component transcriptional regulator (Winged helix family VEA_001207 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) VEA_001210 ENOG4107R0W ABC transporter VEA_001211 ENOG4105BZU Histidine kinase VEA_001212 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) VEA_001213 ENOG4105CPQ Dehydrogenase VEA_001221 ENOG4105D64 Mechanosensitive ion channel VEA_001223 ENOG4105DMF Dehydrogenase VEA_001224 ENOG4105DAA L-lactate VEA_001225 ENOG410642W LysR family Transcriptional regulator VEA_001228 ENOG4108JQ5 ABC transporter VEA_001230 ENOG4105DAN ATP-dependent protease VEA_001231 ENOG4105C8Q Methyl-accepting chemotaxis VEA_001232 ENOG4107QE9 Inherit from COG: Membrane VEA_001233 ENOG4105YE1 PilZ domain VEA_001236 ENOG4105WCN acetyltransferase VEA_001237 ENOG4108BGM Quinol dehydrogenase periplasmic component VEA_001238 ENOG4105GXZ Ferredoxin-type protein NapH VEA_001242 ENOG4108JJB ABC transporter VEA_001243 ENOG4108V7D UPF0397 protein VEA_001244 ENOG4105EFX secretion protein, HlyD family VEA_001245 ENOG4105KK7 inner membrane protein YiaW VEA_001246 ENOG4106TD9 Diguanylate cyclase VEA_001249 ENOG4105D3A purine nucleoside phosphorylase DeoD-type VEA_001250 ENOG4107SEY Conserved Protein VEA_001251 ENOG4108XDN Transcriptional regulator VEA_001252 ENOG4105CVP deoxyribo-dipyrimidine photolyase VEA_001253 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein VEA_001255 ENOG4105C1J atp-dependent rna helicase VEA_001256 ENOG4105CUG Oligopeptidase b VEA_001257 ENOG4105D05 Receptor VEA_001261 ENOG4108NVR Methyl-accepting chemotaxis VEA_001262 ENOG4107S17 Phosphate-binding protein VEA_001263 ENOG4105C8U phosphate abc transporter VEA_001264 ENOG4105E2Z phosphate ABC transporter (Permease VEA_001265 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) VEA_001269 ENOG4107QVM von Willebrand factor, type A VEA_001272 ENOG4105C7R Atpase associated with various cellular activities aaa_3 VEA_001273 ENOG41069D7 Methyl-accepting chemotaxis VEA_001275 ENOG41086KC Transcriptional regulator VEA_001276 ENOG41086KC Transcriptional regulator VEA_001278 ENOG4108JJ6 Type I secretion system ATPase VEA_001281 ENOG4105S6R Iron-hydroxamate transporter permease subunit VEA_001282 ENOG4108HUF Transporter VEA_001283 ENOG4105E0A ABC, transporter VEA_001284 ENOG4105E0K tonB-dependent siderophore receptor VEA_001285 ENOG4105BZ1 (ABC) transporter VEA_001286 ENOG4105BZU Histidine kinase VEA_001289 ENOG4105CZN Potassium uptake protein VEA_001290 ENOG4105ETT transcriptional Regulator, LysR family VEA_001291 ENOG4105C94 Transporter VEA_001292 ENOG4105DVW rieske (2Fe-2S) VEA_001293 ENOG4105C26 Dehydrogenase VEA_001294 ENOG4107QZF nitrite reductase NADPH large subunit VEA_001295 ENOG4105CJP fad dependent oxidoreductase VEA_001297 ENOG4105CK1 PTS System VEA_001299 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 VEA_001300 ENOG4108JUA Transcriptional regulator VEA_001304 ENOG4105EIP mannose-6-phosphate isomerase VEA_001305 ENOG4105DM4 PTS System VEA_001306 ENOG4106R3P AraC family transcriptional regulator VEA_001308 ENOG4108YRF PTS System VEA_001309 ENOG4105DM4 PTS System VEA_001310 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase VEA_001311 ENOG4105CH6 catalase VEA_001312 ENOG4108RXX maleylacetoacetate isomerase VEA_001313 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein VEA_001314 ENOG4108WUH Transcriptional regulator, TetR family VEA_001315 ENOG4105V0I UPF0267 protein VEA_001323 ENOG4105D75 Capsular exopolysaccharide family VEA_001326 ENOG4105D3Q Sugar transferase VEA_001327 ENOG4108IJ9 (ABC) transporter VEA_001328 ENOG4107FKK extracellular solute-binding protein family 1 VEA_001329 ENOG4105D56 permease protein VEA_001330 ENOG4105EG2 ABC transporter, permease VEA_001336 ENOG4105CKW Inner membrane protein yedI VEA_001337 ENOG4105EKE dihydroorotase VEA_001340 ENOG4105QVC MOSC domain-containing protein VEA_001340 ENOG4105QVC MOSC domain-containing protein VEA_001341 ENOG4107RA1 nh(3)-dependent nad( ) synthetase VEA_001342 ENOG4107X4V Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) VEA_001350 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) VEA_001351 ENOG4105EHG Permease protein VEA_001353 ENOG4106GFD transport protein VEA_001354 ENOG41090AP transport protein VEA_001355 ENOG4105WQ5 TonB family VEA_001356 ENOG4105D4P Coproporphyrinogen iii oxidase VEA_001357 ENOG41090JE Utilization Protein VEA_001358 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related VEA_001360 ENOG4107R88 Chemotaxis protein (CheV) VEA_001361 ENOG4105KQ5 peptidylprolyl cis-trans isomerase VEA_001364 ENOG41090EM Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter VEA_001366 ENOG41061MD high-affinity nickel-transporter VEA_001368 ENOG4105C8Q Methyl-accepting chemotaxis VEA_001369 ENOG4105CR8 Transcriptional regulator VEA_001372 ENOG4105KXC Collagenase VEA_001374 ENOG4108Z8I decarboxylase VEA_001379 ENOG4105CKD glutathione-regulated potassium-efflux system protein VEA_001380 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein VEA_001381 ENOG4108M6U Universal stress protein A VEA_001382 ENOG4105C5H ABC transporter VEA_001385 ENOG4105ENT Efflux transporter rnd family, mfp subunit VEA_001387 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation VEA_001389 ENOG4108HK0 -acetyltransferase VEA_001395 ENOG4108IJF Heavy metal efflux pump, CzcA VEA_001399 ENOG4108IEG Formate dehydrogenase Alpha subunit VEA_001402 ENOG4107QWP ABC-2 type transporter VEA_001403 ENOG4105CJ1 ABC, transporter VEA_001405 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) VEA_001406 ENOG4105JAB phenazine biosynthesis protein, phzf family VEA_001407 ENOG4108V1U phospholipid-binding protein VEA_001409 ENOG4105D6J arsenicaL-resistance protein VEA_001412 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia VEA_001413 ENOG4105CTS PTS system mannitol-specific VEA_001414 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein VEA_001416 ENOG4107Z1W Fructose transport system kinase VEA_001420 ENOG4105E0U tyrosine-specific transport protein VEA_001423 ENOG4105C8Q Methyl-accepting chemotaxis VEA_001424 ENOG4105DWD nucleoside recognition domain protein VEA_001428 ENOG4105DR5 peptidase VEA_001430 ENOG4105CR8 Transcriptional regulator VEA_001431 ENOG4105E5M Multidrug resistance protein D VEA_001434 ENOG4105VW4 glutaredoxin 3 VEA_001435 ENOG4108SXK Transporter Drug Metabolite Exporter family VEA_001438 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase VEA_001441 ENOG4105SUT Transcriptional Regulator AraC Family VEA_001446 ENOG4105BZ9 Cytochrome C oxidase, subunit I VEA_001447 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) VEA_001452 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) VEA_001453 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) VEA_001454 ENOG4108V1T peptidylprolyl cis-trans isomerase VEA_001456 ENOG4108ZG0 Ompa motb domain protein VEA_001460 ENOG4105VEQ Cold shock protein VEA_001462 ENOG4105BZU Histidine kinase VEA_001466 ENOG4107R39 (ABC) transporter VEA_001468 ENOG4105C8Q Methyl-accepting chemotaxis VEA_001469 ENOG4108RMU ferritin dps family protein VEA_001472 ENOG4105C0A alcohol dehydrogenase VEA_001473 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain VEA_001478 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) VEA_001479 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) VEA_001480 ENOG4105MIR Phenylalanine 4-monooxygenase VEA_001481 ENOG41090A4 Pterin carbinolamine dehydratase VEA_001485 ENOG4105VRT cytoplasmic protein VEA_001489 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin VEA_001494 ENOG4105HF0 Membrane VEA_001496 ENOG4105C1J atp-dependent rna helicase VEA_001497 ENOG4105VYA Uncharacterized conserved protein (DUF2132) VEA_001499 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) VEA_001500 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) VEA_001501 ENOG4105VEQ Cold shock protein VEA_001503 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) VEA_001505 ENOG4105CKI cobalamin synthesis protein VEA_001506 ENOG4105C1J atp-dependent rna helicase VEA_001510 ENOG4105CXC rtn protein VEA_001511 ENOG4105DKW ABC transporter VEA_001512 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor VEA_001517 ENOG4107VRI Transcriptional regulator VEA_001521 ENOG4105CVA phosphate VEA_001524 ENOG4108ENQ Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) VEA_001525 ENOG4105C1J atp-dependent rna helicase VEA_001526 ENOG4105BZU Histidine kinase VEA_001527 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) VEA_001528 ENOG4107SDU Methyl-accepting chemotaxis VEA_001529 ENOG4105E90 ABC transporter VEA_001530 ENOG4108IJ8 ABC transporter VEA_001531 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component VEA_001532 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system VEA_001535 ENOG4105ECQ AraC Family Transcriptional Regulator VEA_001536 ENOG4107U2T alpha beta VEA_001538 ENOG4105CQB FAD linked oxidase domain protein VEA_001540 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase VEA_001541 ENOG4105E39 Enoyl-CoA hydratase VEA_001542 ENOG4107QX3 carboxylase VEA_001543 ENOG4105C1G acyl-Coa dehydrogenase VEA_001545 ENOG4105CHU acetyl-coa acetyltransferase VEA_001546 ENOG4105C26 Dehydrogenase VEA_001548 ENOG4105E39 Enoyl-CoA hydratase VEA_001549 ENOG4105E39 Enoyl-CoA hydratase VEA_001550 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase VEA_001551 ENOG4105CHR reductase VEA_001553 ENOG4105E2S oxidase) subunit II VEA_001554 ENOG4105BZ9 Cytochrome C oxidase, subunit I VEA_001555 ENOG4105CCU oxidase (Subunit III) VEA_001557 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) VEA_001563 ENOG4105C26 Dehydrogenase VEA_001572 ENOG4105E5Z arginine transporter ATP-binding subunit VEA_001573 ENOG4106PMH Extracellular solute-binding protein family 3 VEA_001574 ENOG4105GBT ABC transporter VEA_001575 ENOG4105DMR ABC, transporter VEA_001578 ENOG4105UYK outer membrane protein a VEA_001581 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase VEA_001582 ENOG4105C10 Electron transfer flavoprotein VEA_001583 ENOG4107QSN dihydrolipoamide acetyltransferase VEA_001584 ENOG4105CPP Dehydrogenase, E1 component VEA_001585 ENOG4107RUY (E1 component), alpha subunit VEA_001588 ENOG4105R8A Heat shock protein VEA_001589 ENOG4106E5D Protein of unknown function (DUF461) VEA_001593 ENOG4105ETX regulatoR VEA_001599 ENOG4105BZU Histidine kinase VEA_001600 ENOG4105C44 Serine transporter VEA_001603 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) VEA_001608 ENOG4105DG7 nitrate ABC transporter VEA_001609 ENOG4105D7T ABC transporter VEA_001611 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) VEA_001614 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate VEA_001615 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) VEA_001616 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase VEA_001617 ENOG4107ZVW dihydroneopterin aldolase VEA_001618 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) VEA_001619 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) VEA_001620 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) VEA_001621 ENOG4105VCC 30S ribosomal protein S21 VEA_001622 ENOG4105KTH gatB Yqey VEA_001623 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) VEA_001624 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VEA_001625 ENOG4105D01 (LipO)protein VEA_001632 ENOG4105CTS PTS system mannitol-specific VEA_001633 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase VEA_001634 ENOG4105E61 Mannitol repressor protein VEA_001637 ENOG4108UTZ Dihydroxyacetone kinase VEA_001638 ENOG4105CMT Dihydroxyacetone kinase VEA_001640 ENOG4105GR3 Histidine kinase VEA_001643 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) VEA_001644 ENOG410804X Transcriptional regulator VEA_001645 ENOG4105CA9 Pyruvate kinase VEA_001647 ENOG4105BZU Histidine kinase VEA_001648 ENOG4108ZP8 Acetolactate synthase small subunit VEA_001649 ENOG4105C7K acetolactate synthase VEA_001650 ENOG4108IQE Amp-dependent synthetase and ligase VEA_001651 ENOG41064T2 transcriptional regulator, lysR family VEA_001656 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) VEA_001657 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) VEA_001658 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) VEA_001659 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) VEA_001661 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) VEA_001662 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) VEA_001663 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) VEA_001664 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) VEA_001665 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) VEA_001666 ENOG4105NWN ApaG protein VEA_001667 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) VEA_001670 ENOG4105DWK Membrane VEA_001671 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control VEA_001672 ENOG4105K46 50S ribosomal protein l27 VEA_001673 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) VEA_001674 ENOG4105EAH synthase VEA_001676 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) VEA_001677 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) VEA_001682 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase VEA_001683 ENOG4105CC0 LysR family Transcriptional regulator VEA_001684 ENOG4107T0D ABC, transporter VEA_001685 ENOG4106SMU thiamine transporter membrane protein VEA_001686 ENOG4105DP9 ABC transporter VEA_001687 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase VEA_001688 ENOG4105DFU Cell wall formation (By similarity) VEA_001689 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 VEA_001690 ENOG4105F0N pyrophosphate phospho-hydrolase VEA_001692 ENOG41066HZ AIG2-like family VEA_001693 ENOG4105MA0 exported protein VEA_001694 ENOG4105CFU surface antigen VEA_001695 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) VEA_001696 ENOG41061GZ Protein of unknown function (DUF1107) VEA_001697 ENOG4108UUE Transcriptional regulator VEA_001700 ENOG4108I0Y (ABC) transporter VEA_001704 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) VEA_001706 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) VEA_001707 ENOG4105C11 sulfate adenylyltransferase), subunit 2 VEA_001708 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) VEA_001709 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic VEA_001711 ENOG4105C1J atp-dependent rna helicase VEA_001712 ENOG4107YB6 acetyltransferase, (GNAT) family VEA_001714 ENOG4108V1T peptidylprolyl cis-trans isomerase VEA_001716 ENOG4108ZT0 50S ribosomal protein l17 VEA_001717 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) VEA_001718 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) VEA_001719 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) VEA_001720 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits VEA_001722 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) VEA_001723 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) VEA_001724 ENOG4105VPB 50S ribosomal protein L30 VEA_001725 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) VEA_001727 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) VEA_001728 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) VEA_001729 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) VEA_001730 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits VEA_001731 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) VEA_001732 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) VEA_001733 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal VEA_001734 ENOG41083MP 50s ribosomal protein l29 VEA_001735 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) VEA_001736 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) VEA_001737 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) VEA_001738 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) VEA_001739 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity VEA_001740 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) VEA_001741 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) VEA_001742 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) VEA_001743 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) VEA_001744 ENOG4105VFB Binds the 23S rRNA (By similarity) VEA_001745 ENOG4105C25 Primosomal protein n' VEA_001746 ENOG4105ETE Transcriptional regulator (LacI family VEA_001748 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) VEA_001749 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) VEA_001750 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase VEA_001751 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) VEA_001752 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) VEA_001754 ENOG4105CBT Fructose-1,6-bisphosphatase VEA_001760 ENOG4105CP7 Triose-phosphate isomerase VEA_001765 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase VEA_001768 ENOG4105CGN Glycosyl transferase (Group 1 VEA_001773 ENOG4107QQG Dehydrogenase VEA_001774 ENOG4105CY0 Metallo-Beta-Lactamase VEA_001775 ENOG4105ESV Glycosyl transferase, family 4 VEA_001776 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase VEA_001777 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) VEA_001784 ENOG41090SZ ABC-2 type transporter VEA_001785 ENOG4105C2X Arabinose 5-phosphate isomerase VEA_001787 ENOG4107V1M polysaccharide export protein VEA_001789 ENOG4108MDC (LipO)protein VEA_001791 ENOG4105E3R (LipO)protein VEA_001792 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) VEA_001793 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase VEA_001794 ENOG4105XA0 heptosyltransferase ii VEA_001795 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase VEA_001796 ENOG41066S7 Glycosyltransferase family 52 VEA_001797 ENOG4105F0R Cytidylyltransferase VEA_001800 ENOG4105D2T synthase VEA_001801 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase VEA_001802 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase VEA_001805 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase VEA_001807 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) VEA_001808 ENOG4105C1B dTDP-glucose 4-6-dehydratase VEA_001809 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) VEA_001810 ENOG41080IJ Diacylglycerol kinase VEA_001811 ENOG4105DKP glycosyl transferase, family 9 VEA_001812 ENOG4106WTF Glycosyl transferase, family 2 VEA_001814 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) VEA_001815 ENOG4108JMC lipopolysaccharide core biosynthesis protein VEA_001817 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) VEA_001820 ENOG4105KDC 50s ribosomal protein l28 VEA_001821 ENOG4105W5Q DNA repair protein (RadC VEA_001822 ENOG4105C8Q Methyl-accepting chemotaxis VEA_001823 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase VEA_001824 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) VEA_001825 ENOG4105D1S lipid A biosynthesis VEA_001826 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) VEA_001827 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) VEA_001828 ENOG4105DSJ YicC domain protein VEA_001835 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) VEA_001836 ENOG4108YGG dna repair protein VEA_001848 ENOG4105BZU Histidine kinase VEA_001850 ENOG4108JQ7 (ABC) transporter VEA_001852 ENOG4107QRA Extracellular solute-binding protein, family 5 VEA_001853 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component VEA_001854 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component VEA_001859 ENOG4109015 Biopolymer transport protein exbD tolR VEA_001862 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) VEA_001863 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) VEA_001864 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) VEA_001865 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase VEA_001866 ENOG4105CB5 ATP-dependent DNA helicase recG VEA_001868 ENOG4105C2W permease VEA_001869 ENOG4105E0F Histidine kinase VEA_001870 ENOG4105DPZ Two component transcriptional regulator (Winged helix family VEA_001872 ENOG4108RRZ Transcription elongation factor GreB VEA_001874 ENOG4105BZM domain protein VEA_001876 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) VEA_001878 ENOG4105MJ2 Competence protein VEA_001879 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) VEA_001880 ENOG4107RK2 ADP-ribose diphosphatase NudE VEA_001882 ENOG4105PIC general secretion pathway protein N VEA_001883 ENOG4105U1E general secretion pathway protein M VEA_001884 ENOG4108BY5 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) VEA_001885 ENOG4108RTD type II secretion system protein K VEA_001886 ENOG4108WWZ General secretion pathway protein J VEA_001887 ENOG4105X5Z General secretion pathway protein I VEA_001888 ENOG4105VWV general secretion pathway protein h VEA_001889 ENOG4108VAU general secretion pathway protein G VEA_001890 ENOG4105D7Q type ii secretion system VEA_001891 ENOG4107QHF type ii secretion system protein e VEA_001893 ENOG4108XKW General secretion pathway protein C VEA_001894 ENOG4105VEJ Heat shock protein VEA_001895 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) VEA_001896 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase VEA_001898 ENOG4105SUU thioesterase domain VEA_001899 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) VEA_001900 ENOG4107S2Z UPF0761 membrane protein VEA_001905 ENOG4105C5F glutamine synthetase VEA_001907 ENOG4105CUX Signal transduction histidine kinase VEA_001908 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VEA_001909 ENOG4105BZU Histidine kinase VEA_001910 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) VEA_001911 ENOG4105D4P Coproporphyrinogen iii oxidase VEA_001912 ENOG4105XCT Protein of unknown function (DUF2489) VEA_001913 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) VEA_001915 ENOG4106RE7 Cytochrome VEA_001916 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) VEA_001917 ENOG4105C2M dna polymerase I VEA_001918 ENOG4105KD7 acetyltransferase VEA_001919 ENOG4105D52 delta-aminolevulinic acid dehydratase VEA_001920 ENOG4105F8V Hydrolase, tatD family VEA_001922 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) VEA_001923 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) VEA_001924 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) VEA_001925 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) VEA_001926 ENOG4105JC1 sterol-binding domain protein VEA_001927 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) VEA_001928 ENOG4105CGY Dna recombination protein VEA_001930 ENOG4105BZU Histidine kinase VEA_001931 ENOG4105DSF transport protein VEA_001937 ENOG4107TE5 Lipid kinase VEA_001942 ENOG4108JUA Transcriptional regulator VEA_001943 ENOG4105CBX hi0933 family VEA_001944 ENOG4108V6B universal stress protein B VEA_001945 ENOG41090A1 ferritin VEA_001946 ENOG4108M6U Universal stress protein A VEA_001947 ENOG4105EMK carboxylate amino acid amine transporter VEA_001949 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) VEA_001950 ENOG4105BZU Histidine kinase VEA_001951 ENOG4108VVK transcriptional Regulator, AsnC VEA_001952 ENOG4105DGW oligopeptidase A VEA_001953 ENOG4105D6S protein involved in catabolism of external DNA VEA_001954 ENOG4105DC8 reductase VEA_001955 ENOG4107RSM transcriptional regulator VEA_001956 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) VEA_001957 ENOG4108UHU Aldolase VEA_001958 ENOG4105C6Z Gluconate VEA_001959 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family VEA_001960 ENOG4105C01 Dihydroxy-acid dehydratase VEA_001962 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) VEA_001963 ENOG41064T2 transcriptional regulator, lysR family VEA_001964 ENOG4105DIQ Transcriptional regulator VEA_001972 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VEA_001973 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component VEA_001974 ENOG4107QSI ABC, transporter VEA_001975 ENOG4108JQ6 ABC transporter VEA_001977 ENOG4105MPD Cytochrome VEA_001978 ENOG4105C4R Atp-dependent dna helicase VEA_001979 ENOG41067SE Tetr family transcriptional regulator VEA_001980 ENOG410624X efflux transporter, rnd family, mfp subunit VEA_001981 ENOG4105BZS acriflavin resistance protein VEA_001982 ENOG4105W0Z cytoplasmic protein VEA_001983 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase VEA_001984 ENOG4105EMY transcriptional regulator VEA_001985 ENOG4108RR8 protoporphyrinogen oxidase VEA_001986 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) VEA_001987 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein VEA_001988 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase VEA_001989 ENOG4105CHU acetyl-coa acetyltransferase VEA_001990 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family VEA_001993 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) VEA_001999 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit VEA_002000 ENOG4105C38 Glycyl-tRNA synthetase beta subunit VEA_002001 ENOG4107T9C Alpha amylase catalytic region VEA_002002 ENOG4105JKW Valine--pyruvate aminotransferase VEA_002003 ENOG4108ZNX Heat shock protein VEA_002006 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) VEA_002007 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) VEA_002008 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) VEA_002009 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) VEA_002010 ENOG4105EAB amino acid AbC transporter VEA_002011 ENOG4105E5Q amino acid AbC transporter VEA_002012 ENOG4105CDA abc transporter atp-binding protein VEA_002014 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) VEA_002015 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) VEA_002016 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins VEA_002017 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) VEA_002018 ENOG4105QTB Flavodoxin VEA_002019 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) VEA_002020 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) VEA_002021 ENOG4107QJE Chromosome Partitioning Protein VEA_002022 ENOG4105FA0 parb-like partition protein VEA_002023 ENOG410684E atp synthase VEA_002024 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) VEA_002025 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) VEA_002027 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) VEA_002028 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) VEA_002029 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) VEA_002030 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) VEA_002031 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) VEA_002032 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) VEA_002033 ENOG4105EAD ABC transporter VEA_002034 ENOG4105F87 Dehydratase VEA_002035 ENOG4105CZQ inner membrane transport protein YdhC VEA_002036 ENOG4105F52 Transcriptional regulator VEA_002037 ENOG4105C7B Threonine dehydratase VEA_002038 ENOG4105C01 Dihydroxy-acid dehydratase VEA_002039 ENOG4105CM2 brancheD-chain amino acid aminotransferase VEA_002040 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit VEA_002042 ENOG4105C0P Mg chelatase subunit ChlI VEA_002044 ENOG4106HNH Acyl-transferase VEA_002045 ENOG4108Z33 Thiol disulfide Interchange Protein VEA_002046 ENOG4105E27 serine threonine protein kinase VEA_002048 ENOG4105PC1 Conserved Protein VEA_002050 ENOG4108N23 SpoOM-related protein VEA_002051 ENOG4108UT2 hemolysin iii VEA_002053 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) VEA_002054 ENOG4105C1A potassium transporter peripheral membrane VEA_002055 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B VEA_002056 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) VEA_002057 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) VEA_002059 ENOG4105C79 DNA protecting protein DprA VEA_002060 ENOG4108RPN Protein smg homolog VEA_002062 ENOG4108WI1 Dna topoisomerase VEA_002063 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit VEA_002064 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) VEA_002065 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) VEA_002066 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) VEA_002067 ENOG4105E2X shikimate dehydrogenase VEA_002068 ENOG4105SG3 Protein of unknown function (DUF1488) VEA_002069 ENOG4108Z0R Transferase VEA_002070 ENOG4105E3B Multicopper oxidase VEA_002071 ENOG4105WMR Protein CrcB homolog VEA_002072 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) VEA_002074 ENOG4105D06 uba thif-type nad fad binding protein VEA_002075 ENOG4105WHD thiamine biosynthesis protein ThiS VEA_002076 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) VEA_002077 ENOG4105D41 biosynthesis protein thiH VEA_002078 ENOG4105DC7 peptidase M24 VEA_002078 ENOG4105DC7 peptidase M24 VEA_002084 ENOG4105E18 UPF0276 protein VEA_002086 ENOG4105C4R Atp-dependent dna helicase VEA_002088 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) VEA_002091 ENOG4105FR1 rard protein VEA_002092 ENOG4105C9U ATP-dependent DNA helicase RecQ VEA_002094 ENOG4105EX9 Membrane VEA_002095 ENOG4105C9X ppx gppa phosphatase VEA_002096 ENOG4105C1J atp-dependent rna helicase VEA_002097 ENOG4105K63 Thioredoxin VEA_002098 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) VEA_002100 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) VEA_002102 ENOG4107QK7 reductase VEA_002103 ENOG410601J HemY protein VEA_002104 ENOG4105ECF c-methyltransferase VEA_002105 ENOG41076E6 Uroporphyrinogen-III Synthase VEA_002106 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) VEA_002107 ENOG4107T0K Adenylate cyclase VEA_002108 ENOG4105XQ6 frataxin-like protein VEA_002110 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) VEA_002111 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) VEA_002113 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) VEA_002114 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant VEA_002115 ENOG4105BZU Histidine kinase VEA_002117 ENOG4106IUH DTW domain containing protein VEA_002120 ENOG4105DQF Hydrolase VEA_002122 ENOG4108EUD Lysophospholipase VEA_002123 ENOG410829K Lysine exporter protein (Lyse ygga) VEA_002124 ENOG4105D58 Diguanylate phosphodiesterase VEA_002125 ENOG41082YX Transcriptional regulator, arsr family VEA_002126 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase VEA_002135 ENOG41076UM multiple antibiotic resistance (MarC)-related protein VEA_002137 ENOG4106H78 methyltransferase VEA_002138 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) VEA_002139 ENOG4105CAK Cell division ATP-binding protein ftsE VEA_002140 ENOG4105CRP Part of the ABC transporter FtsEX involved in VEA_002141 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VEA_002142 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) VEA_002143 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) VEA_002144 ENOG4105X6C Flagellar basal body-associated protein FliL VEA_002145 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) VEA_002146 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) VEA_002147 ENOG4105E55 glycerol-3-phosphate acyltransferase VEA_002149 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) VEA_002151 ENOG4107R73 Mate efflux family protein VEA_002152 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) VEA_002155 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) VEA_002156 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) VEA_002158 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) VEA_002160 ENOG4105JIM Phosphatidylserine synthase VEA_002162 ENOG4105D4A Cell wall formation (By similarity) VEA_002163 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase VEA_002164 ENOG4105CS9 pantothenic acid kinase VEA_002166 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) VEA_002167 ENOG4105PM1 preprotein translocase subunit SecE VEA_002168 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) VEA_002169 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) VEA_002170 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) VEA_002171 ENOG4108VZM 50s ribosomal protein L10 VEA_002172 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) VEA_002173 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) VEA_002174 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) VEA_002175 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor VEA_002176 ENOG4105E09 nadh pyrophosphatase VEA_002177 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) VEA_002178 ENOG4108RG0 uracil-dna glycosylase VEA_002179 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase VEA_002180 ENOG4105R2J Conserved Protein VEA_002184 ENOG4105C12 Phosphoribosylglycinamide synthetase VEA_002185 ENOG4105DC1 bifunctional purine biosynthesis protein purh VEA_002186 ENOG4105W1Y Transcriptional regulator VEA_002187 ENOG4108M3R transcriptional activator CadC VEA_002188 ENOG4105D5Q Arginine ornithine antiporter VEA_002189 ENOG4105CXN decarboxylase VEA_002191 ENOG4105C5H ABC transporter VEA_002193 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) VEA_002194 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) VEA_002195 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) VEA_002196 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase VEA_002197 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein VEA_002198 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) VEA_002199 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) VEA_002202 ENOG4105D8G Major Facilitator superfamily VEA_002203 ENOG4105BZU Histidine kinase VEA_002204 ENOG4105C9Q fumarate hydratase class II VEA_002207 ENOG4107QN1 sodium solute VEA_002210 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) VEA_002212 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) VEA_002213 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter VEA_002214 ENOG4108IJ0 Aspartate ammonia-lyase VEA_002216 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) VEA_002218 ENOG4105E0F Histidine kinase VEA_002219 ENOG4105E3W Two component transcriptional regulator (Winged helix family VEA_002220 ENOG4108SPG Periplasmic Protein VEA_002221 ENOG41076HS cation diffusion facilitator family transporter VEA_002222 ENOG4105CTQ phosphohexokinase VEA_002223 ENOG4107QI1 Mate efflux family protein VEA_002224 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) VEA_002225 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) VEA_002230 ENOG4105KT7 mgtC SapB transporter VEA_002231 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein VEA_002232 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) VEA_002234 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) VEA_002235 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) VEA_002236 ENOG4105E33 succinate dehydrogenase VEA_002238 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) VEA_002240 ENOG41062JF Transcriptional regulator VEA_002242 ENOG41063SB peptidase VEA_002243 ENOG4105D7W serine acetyltransferase VEA_002244 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase VEA_002245 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) VEA_002246 ENOG4107YZP Rhodanese domain protein VEA_002247 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) VEA_002250 ENOG4105DJ4 phosphatidylserine decarboxylase VEA_002251 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) VEA_002252 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) VEA_002253 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) VEA_002255 ENOG4105K8N protein family UPF0079, ATPase VEA_002256 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase VEA_002257 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) VEA_002258 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) VEA_002259 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) VEA_002260 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) VEA_002261 ENOG4107QJR hflk protein VEA_002262 ENOG4105EPW hflc protein VEA_002264 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis VEA_002265 ENOG4108UV7 flagellar protein motX VEA_002266 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) VEA_002267 ENOG4105KPV Transcriptional regulator VEA_002268 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) VEA_002269 ENOG4105C2N RNA methyltransferase TrmH family group 3 VEA_002270 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) VEA_002271 ENOG4105C31 Tryptophanyl-tRNA synthetase VEA_002275 ENOG4105C8Y Acetylornithine aminotransferase VEA_002277 ENOG4105C26 Dehydrogenase VEA_002279 ENOG4107RYR Transcriptional regulator, Crp Fnr family VEA_002280 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) VEA_002281 ENOG4105YP7 UPF0270 protein VEA_002282 ENOG4105DNZ Alpha Beta Hydrolase VEA_002284 ENOG4105C5H ABC transporter VEA_002285 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein VEA_002288 ENOG4108YZY peptidylprolyl cis-trans isomerase VEA_002289 ENOG4105D44 asparaginase VEA_002290 ENOG41069P5 Protein slyX homolog VEA_002292 ENOG4108V1T peptidylprolyl cis-trans isomerase VEA_002293 ENOG4105WWK YheO domain protein VEA_002294 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) VEA_002295 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) VEA_002296 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) VEA_002297 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) VEA_002298 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) VEA_002299 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) VEA_002300 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) VEA_002302 ENOG4108UQY Iron-storage protein VEA_002303 ENOG4105C6K Malic enzyme VEA_002304 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) VEA_002306 ENOG4105C28 cystathionine VEA_002307 ENOG4105CFH Aspartokinase VEA_002308 ENOG4105SYT Methylenetetrahydrofolate reductase VEA_002310 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) VEA_002311 ENOG4105CWC Acetylornithine deacetylase VEA_002312 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase VEA_002313 ENOG4105CAS nag kinase VEA_002314 ENOG4105CDH Citrulline--aspartate ligase VEA_002315 ENOG4105CH7 arginosuccinase VEA_002319 ENOG4105EHV domain protein VEA_002321 ENOG4108JQC penicillin-binding protein 1A VEA_002326 ENOG4105E4G Type IV pilus VEA_002327 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) VEA_002328 ENOG4105D49 3-dehydroquinate synthase VEA_002330 ENOG4105DFE Dna adenine methylase VEA_002331 ENOG4105DJV ribulose-phosphate 3-epimerase VEA_002332 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) VEA_002333 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) VEA_002334 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) VEA_002335 ENOG4105K9Q Binds to the 23S rRNA (By similarity) VEA_002337 ENOG4105CDU Replicative dna helicase VEA_002338 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) VEA_002339 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme VEA_002341 ENOG4107QP8 phosphohexose isomerase VEA_002343 ENOG4105MYN Zinc uptake regulation protein VEA_002346 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) VEA_002350 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) VEA_002351 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) VEA_002352 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) VEA_002354 ENOG4105EEQ Na H antiporter VEA_002355 ENOG4105C3R Methionine synthase VEA_002356 ENOG4105CFH Aspartokinase VEA_002358 ENOG4105C5R Aminotransferase VEA_002360 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) VEA_002361 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase VEA_002362 ENOG41086KC Transcriptional regulator VEA_002363 ENOG4108UUM single-stranded DNA-binding protein VEA_002364 ENOG41062P1 Diguanylate cyclase phosphodiesterase VEA_002371 ENOG4107QHF type ii secretion system protein e VEA_002372 ENOG4105D7Q type ii secretion system VEA_002383 ENOG4105DFF Rod shape-determining protein mreb VEA_002384 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) VEA_002385 ENOG4105VQ7 Rod shape-determining protein MreD VEA_002386 ENOG4108Z03 MAF-like protein VEA_002387 ENOG4105C03 ribonuclease VEA_002388 ENOG4105QD6 exported protein VEA_002390 ENOG4105D1U peptidase U62 modulator of DNA gyrase VEA_002391 ENOG4108IAB Phoh family VEA_002392 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) VEA_002393 ENOG4105K3M )-transporter VEA_002394 ENOG4105D3G Pseudouridine synthase VEA_002395 ENOG4105C5I Dehydrogenase VEA_002396 ENOG4105N42 UPF0307 protein VEA_002397 ENOG4105CMS peptidase U62, modulator of DNA gyrase VEA_002398 ENOG4105CJW magnesium transporter VEA_002399 ENOG41080Z8 PHOSPHOCARRIER protein VEA_002400 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) VEA_002401 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN VEA_002402 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA VEA_002403 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VEA_002404 ENOG4108IUZ ABC transporter VEA_002405 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA VEA_002407 ENOG4105C2X Arabinose 5-phosphate isomerase VEA_002409 ENOG4105DHJ ABC, transporter VEA_002410 ENOG4105CY3 ABC transporter, permease VEA_002411 ENOG4107PE3 Mammalian cell entry related domain protein VEA_002412 ENOG4105E3I toluene tolerance VEA_002414 ENOG4105VFK BolA family VEA_002415 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) VEA_002416 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase VEA_002417 ENOG4105KME endoribonuclease L-psp VEA_002418 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) VEA_002419 ENOG4105CXT aspartate transcarbamylase VEA_002420 ENOG4105DBV ornithine carbamoyltransferase VEA_002421 ENOG4105CEU Arginine dihydrolase VEA_002424 ENOG4108MJ3 acetyltransferase VEA_002426 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) VEA_002427 ENOG4105MYG DNA polymerase iii, chi subunit VEA_002428 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) VEA_002429 ENOG4108M8S permease YjgP YjgQ family protein VEA_002430 ENOG4108K5H permease YjgP YjgQ family protein VEA_002432 ENOG4105EXU Membrane VEA_002433 ENOG41061TZ Short-chain dehydrogenase reductase Sdr VEA_002436 ENOG4105CK1 PTS System VEA_002437 ENOG4105VCP PTS System VEA_002438 ENOG4105F8D glycoside hydrolase family 4 VEA_002439 ENOG410901P UPF0249 protein VEA_002441 ENOG4108ESY Metal dependent phosphohydrolase VEA_002442 ENOG4105C26 Dehydrogenase VEA_002443 ENOG4105C8Q Methyl-accepting chemotaxis VEA_002445 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) VEA_002446 ENOG4105CEN a g-specific adenine glycosylase VEA_002447 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) VEA_002449 ENOG4105CSV Glutaminase VEA_002450 ENOG4105CSA Coproporphyrinogen iii oxidase VEA_002451 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) VEA_002453 ENOG4105VZ9 UPF0235 protein VEA_002454 ENOG4108VIA integral membrane protein VEA_002455 ENOG4105II7 pyrroline-5-carboxylate reductase VEA_002457 ENOG4105DFA alanine racemase domain protein VEA_002458 ENOG4105CZX twitching motility protein VEA_002459 ENOG4105CZX twitching motility protein VEA_002460 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) VEA_002461 ENOG4108UJU UPF0301 protein VEA_002462 ENOG4105D7Z glutathione synthase VEA_002463 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) VEA_002464 ENOG4105RWS endonuclease I VEA_002465 ENOG4105GPY SprT protein VEA_002467 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP VEA_002468 ENOG4105CV1 Transketolase (EC 2.2.1.1) VEA_002469 ENOG4108R4R Iron-regulated virulence regulatory protein VEA_002470 ENOG4105D05 Receptor VEA_002471 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase VEA_002472 ENOG4105BZA Phosphoglycerate kinase VEA_002473 ENOG4105D2N Aldolase VEA_002474 ENOG4105D64 Mechanosensitive ion channel VEA_002477 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) VEA_002478 ENOG4105MPN Membrane VEA_002479 ENOG4108JQ1 Dehydrogenase VEA_002480 ENOG4105E66 phosphoriboisomerase A VEA_002481 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase VEA_002482 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) VEA_002484 ENOG4105D0A hydroxylase VEA_002485 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family VEA_002488 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) VEA_002489 ENOG4105Y75 tpr repeat protein VEA_002490 ENOG4108IYU L-aspartate oxidase VEA_002491 ENOG4105EMN RNA polymerase sigma factor VEA_002495 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) VEA_002496 ENOG4105C3F Signal peptidase i VEA_002497 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) VEA_002498 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) VEA_002499 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) VEA_002500 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) VEA_002501 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) VEA_002502 ENOG4105BZU Histidine kinase VEA_002503 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) VEA_002504 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) VEA_002505 ENOG4105DXN mazG family VEA_002506 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) VEA_002507 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) VEA_002509 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) VEA_002510 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) VEA_002511 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) VEA_002512 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) VEA_002513 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) VEA_002514 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) VEA_002516 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VEA_002517 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) VEA_002518 ENOG4107TH8 cina domain protein VEA_002519 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) VEA_002520 ENOG4105Y3E Modulates RecA activity (By similarity) VEA_002521 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) VEA_002522 ENOG4105CFH Aspartokinase VEA_002523 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) VEA_002525 ENOG4107QSA Oxaloacetate decarboxylase VEA_002526 ENOG4105D9Q decarboxylase (Beta subunit) VEA_002528 ENOG4105W39 Membrane VEA_002530 ENOG4105D9M gamma-glutamylcysteine synthetase VEA_002533 ENOG4108JU6 CBS domain protein VEA_002534 ENOG4106KVJ cytochrome C assembly protein VEA_002535 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY VEA_002536 ENOG4105K5M 30s ribosomal protein S16 VEA_002537 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) VEA_002538 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) VEA_002539 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) VEA_002540 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) VEA_002541 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) VEA_002542 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) VEA_002543 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) VEA_002544 ENOG4105D7Q type ii secretion system VEA_002545 ENOG4107QHF type ii secretion system protein e VEA_002546 ENOG4108ZUW Major pilin subunit VEA_002547 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase VEA_002549 ENOG41073TP transcriptional regulator VEA_002550 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) VEA_002551 ENOG4107QSN dihydrolipoamide acetyltransferase VEA_002552 ENOG4107QN2 dihydrolipoyl dehydrogenase VEA_002553 ENOG410630P Transcriptional regulator VEA_002554 ENOG4108UGV hypoxanthine phosphoribosyltransferase VEA_002555 ENOG41077A9 carbonic anhydrase VEA_002556 ENOG4105CHH sulfate transporter VEA_002557 ENOG4105DA5 (ABC) transporter VEA_002558 ENOG4105E3A (ABC) transporter VEA_002559 ENOG4105D1S lipid A biosynthesis VEA_002560 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) VEA_002561 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) VEA_002562 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase VEA_002563 ENOG4105DJ0 Poly(A) Polymerase VEA_002564 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) VEA_002565 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters VEA_002566 ENOG4105PW4 Sugar fermentation stimulation protein homolog VEA_002567 ENOG4105CQ7 ATP-dependent helicase VEA_002568 ENOG4105BZ4 penicillin-binding protein VEA_002569 ENOG4105D78 K07001 NTE family protein VEA_002570 ENOG4107QIJ Aconitate hydratase 2 VEA_002571 ENOG4105XTV UPF0231 protein VEA_002572 ENOG4108YZA Nitrogen regulatory protein pii VEA_002576 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) VEA_002577 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) VEA_002579 ENOG4105E2D ec 3.2.1.52 VEA_002580 ENOG4105RD7 BadF BadG BcrA BcrD VEA_002582 ENOG4108JQ7 (ABC) transporter VEA_002583 ENOG4105C3U ABC transporter VEA_002584 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VEA_002586 ENOG4107QRA Extracellular solute-binding protein, family 5 VEA_002587 ENOG4105BZU Histidine kinase VEA_002588 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) VEA_002589 ENOG4105F4G Membrane VEA_002591 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase VEA_002592 ENOG4108YX9 iron--sulfur cluster insertion protein erpA VEA_002595 ENOG4105DR5 peptidase VEA_002596 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) VEA_002598 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase VEA_002599 ENOG4107QE9 Inherit from COG: Membrane VEA_002600 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) VEA_002601 ENOG4105HBR Rna-binding protein VEA_002602 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) VEA_002603 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) VEA_002604 ENOG4105EEI dihydropteroate synthase VEA_002605 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) VEA_002607 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) VEA_002608 ENOG4105CHV Transcription elongation factor NusA VEA_002609 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) VEA_002610 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) VEA_002611 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) VEA_002612 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) VEA_002613 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) VEA_002616 ENOG4105C3S Mate efflux family protein VEA_002617 ENOG4106RZ4 Peptidase U32 VEA_002618 ENOG4105CFP Peptidase U32 VEA_002619 ENOG4105BZU Histidine kinase VEA_002620 ENOG4105XPQ lipid carrier protein VEA_002621 ENOG4108YYD acetyltransferase VEA_002625 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) VEA_002627 ENOG4105EYA deoxyribonuclease VEA_002628 ENOG4105D9N nucleoside VEA_002629 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) VEA_002630 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) VEA_002631 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) VEA_002632 ENOG4105D3A purine nucleoside phosphorylase DeoD-type VEA_002634 ENOG4105EAC phosphoserine phosphatase VEA_002636 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) VEA_002637 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) VEA_002638 ENOG4105ETT transcriptional Regulator, LysR family VEA_002639 ENOG4108IQE Amp-dependent synthetase and ligase VEA_002655 ENOG41064T2 transcriptional regulator, lysR family VEA_002656 ENOG4105E5D amino acid VEA_002657 ENOG4105FK9 beta-D-galactosidase beta subunit VEA_002658 ENOG4105CNT hydrolase family 2 VEA_002659 ENOG4105CQ4 Transcriptional regulator VEA_002660 ENOG4105CMR udp-glucose 4-epimerase VEA_002661 ENOG4105F0Z galactose-1-phosphate uridylyltransferase VEA_002662 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) VEA_002663 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) VEA_002664 ENOG4105ETE Transcriptional regulator (LacI family VEA_002666 ENOG4105CT4 transporter VEA_002667 ENOG41060NJ transcriptional regulator VEA_002668 ENOG4108Y51 tRNA-binding protein VEA_002673 ENOG4105C6V Glycerol-3-phosphate dehydrogenase VEA_002674 ENOG4105E98 transcriptional regulator DeoR family VEA_002675 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) VEA_002676 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) VEA_002677 ENOG4105CXY transporter VEA_002678 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase VEA_002679 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) VEA_002680 ENOG4105X2V dna damage-inducible protein VEA_002681 ENOG4105EVZ LysR family transcriptional regulator VEA_002683 ENOG4105E68 Sulfatase VEA_002684 ENOG4105DSY exodeoxyribonuclease V, gamma VEA_002685 ENOG4107QKA exodeoxyribonuclease V beta VEA_002686 ENOG4107QYX exodeoxyribonuclease v alpha VEA_002688 ENOG4107QZM n-acetylglutamate synthase VEA_002690 ENOG4105CA3 membrane-bound lytic murein transglycosylase VEA_002691 ENOG4105CUZ uba thif-type nad fad binding protein VEA_002692 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) VEA_002693 ENOG4105BZU Histidine kinase VEA_002694 ENOG4105C9B Cysteine desulfurase VEA_002695 ENOG4107S0N DJ-1 family VEA_002696 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) VEA_002700 ENOG4105K6V RNA polymerase VEA_002703 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) VEA_002704 ENOG4105IEY (LipO)protein VEA_002705 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) VEA_002706 ENOG4105M85 Bola protein VEA_002707 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) VEA_002708 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) VEA_002709 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) VEA_002710 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) VEA_002711 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) VEA_002712 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) VEA_002713 ENOG4105CJ2 (LipO)protein VEA_002716 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) VEA_002717 ENOG4105C9U ATP-dependent DNA helicase RecQ VEA_002721 ENOG4105C8J )-transporter VEA_002723 ENOG4105W1I UPF0253 protein VEA_002725 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) VEA_002726 ENOG4108R96 Methyltransferase, YaeB family VEA_002727 ENOG4105NRA 50s ribosomal protein l31 type b VEA_002729 ENOG4105CFC Transporter VEA_002734 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase VEA_002735 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) VEA_002736 ENOG4108UPT UPF0178 protein VEA_002741 ENOG4105DR9 pseudouridine synthase VEA_002742 ENOG4105DR9 pseudouridine synthase VEA_002743 ENOG4108T8E UPF0325 protein VEA_002744 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) VEA_002745 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) VEA_002746 ENOG4105CE9 30S ribosomal protein S2 VEA_002747 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) VEA_002748 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) VEA_002749 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) VEA_002750 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) VEA_002751 ENOG4105KNE Phosphatidate cytidylyltransferase VEA_002752 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) VEA_002753 ENOG4105DZP Membrane-associated zinc metalloprotease VEA_002755 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) VEA_002756 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) VEA_002758 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) VEA_002759 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) VEA_002760 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) VEA_002761 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) VEA_002762 ENOG4105C0B DNA polymerase III (alpha subunit) VEA_002763 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) VEA_002764 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) VEA_002765 ENOG4105N7H Cytochrome VEA_002766 ENOG4108YZA Nitrogen regulatory protein pii VEA_002767 ENOG4107NA1 Endonuclease Exonuclease phosphatase VEA_002769 ENOG4105E9H Lytic Murein transglycosylase VEA_002770 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) VEA_002771 ENOG4105D1A Methyltransferase VEA_002772 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) VEA_002773 ENOG4108JDX DNA polymerase iii, epsilon subunit VEA_002777 ENOG4107QPN acyl-Coa dehydrogenase VEA_002778 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) VEA_002779 ENOG4105E7A Glutamine amidotransferase VEA_002780 ENOG4108V3E phosphoribosylglycinamide formyltransferase VEA_002781 ENOG4105CXB phosphoribosylaminoimidazole synthetase VEA_002782 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) VEA_002783 ENOG4105C2W permease VEA_002786 ENOG4105CS1 NAD(P)H quinone oxidoreductase VEA_002787 ENOG4105K89 arsenate reductase VEA_002788 ENOG4105ERG peptidase m48, ste24p VEA_002791 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen VEA_002794 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) VEA_002797 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) VEA_002798 ENOG4105KUZ arsenate reductase VEA_002802 ENOG4105QZU Inner membrane protein YfeZ VEA_002803 ENOG4105EZR dyp-type peroxidase family protein VEA_002804 ENOG4105I03 Flagellin VEA_002805 ENOG4105I03 Flagellin VEA_002806 ENOG4105I03 Flagellin VEA_002807 ENOG41063QE flagellar protein FlaG VEA_002808 ENOG4107BRV flagellar capping protein VEA_002810 ENOG4105MQ3 flagellar protein FliS VEA_002811 ENOG4108JUA Transcriptional regulator VEA_002812 ENOG4105BZU Histidine kinase VEA_002813 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VEA_002814 ENOG4105VQ0 flagellar hook-basal body complex protein fliE VEA_002815 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) VEA_002816 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) VEA_002818 ENOG4108JIR Flagellum-specific ATP synthase VEA_002822 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) VEA_002823 ENOG4105DD5 Flagellar motor switch protein VEA_002824 ENOG4105VTB flagellar biosynthesis protein fliO VEA_002825 ENOG4105CN7 Flagellar biosynthetic protein FliP VEA_002826 ENOG4105VS8 Flagellar biosynthetic protein fliq VEA_002827 ENOG4105D19 Role in flagellar biosynthesis (By similarity) VEA_002828 ENOG4105D00 flagellar biosynthetic protein flhB VEA_002829 ENOG4105D7B Flagellar biosynthesis protein flha VEA_002830 ENOG4105FZW flagellar biosynthesis regulator FlhF VEA_002831 ENOG4107R21 site-determining protein VEA_002832 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VEA_002833 ENOG4108VYJ response regulator receiver protein VEA_002834 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) VEA_002835 ENOG4105CBS Chea signal transduction histidine kinase VEA_002836 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) VEA_002837 ENOG4107QJE Chromosome Partitioning Protein VEA_002839 ENOG4108V3W Chemotaxis protein, CheW VEA_002841 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) VEA_002842 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) VEA_002843 ENOG41060IM Heme exporter protein VEA_002844 ENOG4105X3C heme exporter protein VEA_002845 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) VEA_002846 ENOG4105DA4 cytochrome c-type biogenesis protein VEA_002847 ENOG4107QX9 Thiol disulfide interChange protein VEA_002848 ENOG4108M1T Cytochrome c-type biogenesis protein VEA_002849 ENOG4105KWW Biogenesis protein VEA_002850 ENOG410903C (LipO)protein VEA_002851 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation VEA_002852 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation VEA_002856 ENOG4105CHU acetyl-coa acetyltransferase VEA_002857 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase VEA_002859 ENOG4107QXK peptidase VEA_002860 ENOG4108BY2 phosphohistidine phosphatase VEA_002861 ENOG4108DG9 Smr protein MutS2 VEA_002862 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) VEA_002863 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase VEA_002864 ENOG4105EN6 Membrane VEA_002866 ENOG4108BPE -transporting atpase VEA_002867 ENOG4105MH2 YfcL protein VEA_002868 ENOG4105Q8W reductase VEA_002869 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) VEA_002870 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) VEA_002871 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) VEA_002872 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) VEA_002874 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) VEA_002875 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) VEA_002876 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase VEA_002877 ENOG4108S3P Sporulation domain protein VEA_002878 ENOG4105E96 Colicin v production protein VEA_002879 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase VEA_002880 ENOG4105EJC lysr family transcriptional regulator VEA_002881 ENOG4105I93 response regulator VEA_002884 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) VEA_002885 ENOG4107QMP dna polymerase iii subunits gamma and tau VEA_002886 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) VEA_002887 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) VEA_002890 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) VEA_002891 ENOG4105C44 Serine transporter VEA_002892 ENOG4105KME endoribonuclease L-psp VEA_002893 ENOG4105CEM UPF0597 protein VEA_002895 ENOG4105KRS Proteinase inhibitor VEA_002896 ENOG4105Y3U Transglycosylase-associated protein VEA_002897 ENOG4108ZZ3 UPF0260 protein VEA_002899 ENOG41067V3 Antibiotic biosynthesis monooxygenase VEA_002900 ENOG4108UYE Lactoylglutathione lyase VEA_002902 ENOG4105G6Z alkaline phosphatase VEA_002905 ENOG4105DHI Methyltransferase VEA_002906 ENOG4105C8Q Methyl-accepting chemotaxis VEA_002907 ENOG4105DSB aldose 1-epimerase VEA_002908 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase VEA_002909 ENOG4105E0X reductase VEA_002911 ENOG4105VUT cytoplasmic protein VEA_002912 ENOG4105HDK L-asparaginase VEA_002913 ENOG4105D07 Signal peptide peptidase, SppA VEA_002914 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase VEA_002916 ENOG41069NU Nitroreductase VEA_002917 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) VEA_002919 ENOG4108RU0 short-chain dehydrogenase reductase VEA_002921 ENOG4105DGU Histone deacetylase VEA_002922 ENOG4105E68 Sulfatase VEA_002923 ENOG4105YDX UPF0352 protein VEA_002924 ENOG4106V8H Nucleoid-associated protein VEA_002927 ENOG4105DFD Na H antiporter VEA_002928 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) VEA_002929 ENOG4105EYW Ion transport protein VEA_002930 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein VEA_002931 ENOG4108EKI Dehydrogenase VEA_002934 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) VEA_002935 ENOG4105M2J Glutaredoxin VEA_002937 ENOG4105D3Y Na H antiporter VEA_002938 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) VEA_002940 ENOG4105EIY sodium-type flagellar protein motY VEA_002941 ENOG4106WH9 Protein of unknown function (DUF2753) VEA_002942 ENOG4108UYE Lactoylglutathione lyase VEA_002943 ENOG4105CSM endonuclease III VEA_002944 ENOG4105DZB Electron transport complex VEA_002945 ENOG4108UQQ Electron transport complex VEA_002946 ENOG4105D6A Electron transport complex VEA_002948 ENOG4108R3D Electron transport complex VEA_002949 ENOG4105DGN Electron transport complex VEA_002950 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) VEA_002951 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VEA_002953 ENOG4105CHW UPF0052 protein VEA_002954 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) VEA_002955 ENOG4108RIR Molybdenum cofactor biosynthesis protein VEA_002956 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) VEA_002957 ENOG4105M00 molybdopterin converting factor, subunit 1 VEA_002958 ENOG4108ZAF Molybdopterin VEA_002959 ENOG4107QSI ABC, transporter VEA_002960 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component VEA_002961 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VEA_002962 ENOG4105C3U ABC transporter VEA_002963 ENOG4108JQ7 (ABC) transporter VEA_002964 ENOG4105CHF Glutathione S-transferase VEA_002966 ENOG4107PU6 Membrane VEA_002967 ENOG4108DNC Involved in acetate metabolism (By similarity) VEA_002968 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) VEA_002969 ENOG4105PQ6 UPF0208 membrane protein VEA_002971 ENOG4105C7J ABC transporter, permease VEA_002972 ENOG4108JJB ABC transporter VEA_002973 ENOG4107R28 alpha amylase, catalytic region VEA_002974 ENOG4105BZU Histidine kinase VEA_002975 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) VEA_002976 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving VEA_002977 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) VEA_002979 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) VEA_002981 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) VEA_002982 ENOG4105D1F ATP-binding protein VEA_002983 ENOG4105DBI uridine monophosphokinase VEA_002985 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase VEA_002986 ENOG4105KJF protein tyrosine phosphatase VEA_002987 ENOG4105CHH sulfate transporter VEA_002988 ENOG4105C03 ribonuclease VEA_002989 ENOG4105EI2 Pseudouridine synthase VEA_002990 ENOG4108UHJ MAF-like protein VEA_002991 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein VEA_002992 ENOG4105VGS 50s ribosomal protein l32 VEA_002993 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) VEA_002994 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) VEA_002995 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase VEA_002996 ENOG4105CHR reductase VEA_002997 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) VEA_002998 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) VEA_003000 ENOG4105HHA aminodeoxychorismate lyase VEA_003001 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) VEA_003002 ENOG4107QRG dna polymerase iii VEA_003003 ENOG4105F8V Hydrolase, tatD family VEA_003004 ENOG4105CI1 PTS System VEA_003007 ENOG4105C8J )-transporter VEA_003010 ENOG4108NRW Phospholipase, patatin family VEA_003011 ENOG4105CA9 Pyruvate kinase VEA_003012 ENOG4105DAG ROK family VEA_003013 ENOG4107R88 Chemotaxis protein (CheV) VEA_003014 ENOG4105C0B DNA polymerase III (alpha subunit) VEA_003017 ENOG4105UBK short-chain dehydrogenase reductase VEA_003018 ENOG4105ERU peptidase VEA_003019 ENOG4105CAT Cytidine monophosphate kinase VEA_003020 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) VEA_003021 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) VEA_003022 ENOG4105Q4A inner membrane protein yciS VEA_003023 ENOG4105CFV Tetratricopeptide repeat protein VEA_003024 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) VEA_003025 ENOG4108J59 Extracellular solute-binding protein, family 5 VEA_003028 ENOG4105DY2 Paraquat-inducible protein b VEA_003029 ENOG4105F1S paraquat-inducible protein a VEA_003030 ENOG4105NQN cytochrome C VEA_003032 ENOG4105DB1 molybdopterin oxidoreductase VEA_003033 ENOG4106WHD Tetrathionate reductase VEA_003034 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein VEA_003035 ENOG4106AFQ Histidine kinase VEA_003036 ENOG4108ZXC Two component transcriptional regulator, luxr family VEA_003038 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) VEA_003039 ENOG4105N6Y Thioredoxin VEA_003042 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) VEA_003046 ENOG4105DJY efflux transporter, rnd family, mfp subunit VEA_003049 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) VEA_003050 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) VEA_003054 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) VEA_003056 ENOG4105J12 Multidrug resistance protein mdtN VEA_003057 ENOG4105JQN Transcriptional regulator VEA_003061 ENOG41062D9 Histidine kinase VEA_003062 ENOG4105CK6 Two component transcriptional regulator (Winged helix family VEA_003063 ENOG4105C8Q Methyl-accepting chemotaxis VEA_003066 ENOG4105CCT upf0313 protein VEA_003070 ENOG4105DZ2 Transcriptional regulator VEA_003071 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) VEA_003073 ENOG4105K9H YciI-like protein VEA_003074 ENOG4105NAU thioesterase Superfamily protein VEA_003075 ENOG4107835 probably involved in intracellular septation (By similarity) VEA_003077 ENOG4105BZU Histidine kinase VEA_003079 ENOG4105CK2 sodium dicarboxylate symporter VEA_003081 ENOG4105CEY Amp-dependent synthetase and ligase VEA_003082 ENOG4105DS0 Transcriptional regulator, Crp Fnr family VEA_003083 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) VEA_003084 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) VEA_003085 ENOG4105DK0 Indole-3-glycerol phosphate synthase VEA_003086 ENOG4108I0Q anthranilate phosphoribosyltransferase VEA_003087 ENOG4105DDQ anthranilate synthase VEA_003088 ENOG4105CRQ synthase (Component I) VEA_003090 ENOG4105DB7 PHP domain protein VEA_003091 ENOG4107RTD sua5 ycio yrdc ywlc family protein VEA_003093 ENOG4105FE9 pseudouridine synthase VEA_003094 ENOG4108W5H UPF0263 protein VEA_003097 ENOG4105CQ2 DNA polymerase VEA_003098 ENOG4105WH1 Two component transcriptional regulator luxr family VEA_003099 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) VEA_003103 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) VEA_003108 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) VEA_003109 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) VEA_003110 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) VEA_003111 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) VEA_003114 ENOG4105EAU Plays a role in nitrite reduction (By similarity) VEA_003116 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein VEA_003117 ENOG4105DVI reductase, NrfD VEA_003118 ENOG4105DA4 cytochrome c-type biogenesis protein VEA_003119 ENOG4107QX9 Thiol disulfide interChange protein VEA_003120 ENOG4108DMF Cytochrome C biogenesis protein VEA_003122 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) VEA_003127 ENOG4105DIT ErfK YbiS YcfS YnhG family protein VEA_003128 ENOG4105EAQ (twin-arginine translocation) pathway signal VEA_003129 ENOG4105C5X domain protein VEA_003132 ENOG4105CH5 extracellular solute-binding protein, family 7 VEA_003134 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VEA_003138 ENOG4105C94 Transporter VEA_003139 ENOG4105C8Q Methyl-accepting chemotaxis VEA_003143 ENOG4105CGF Aromatic amino acid aminotransferase VEA_003147 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family VEA_003150 ENOG4105C5S asparaginyl-tRNA synthetase VEA_003151 ENOG4105C8Q Methyl-accepting chemotaxis VEA_003152 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase VEA_003154 ENOG4105BZU Histidine kinase VEA_003155 ENOG4105EJQ L-serine dehydratase VEA_003156 ENOG4105C44 Serine transporter VEA_003157 ENOG4105P8F nudix hydrolase VEA_003160 ENOG4105CRQ synthase (Component I) VEA_003163 ENOG4105CM6 amino acid regulated cytosolic protein VEA_003164 ENOG4106K28 UPF0283 membrane protein VEA_003166 ENOG4105D9U N-acetyltransferase VEA_003207 ENOG4105K5X acetyltransferase VEA_003217 ENOG4108QDQ Ubiquinol-cytochrome C chaperone VEA_003219 ENOG4105CAT Cytidine monophosphate kinase VEA_003234 ENOG4105CVR type I restriction-modification system VEA_003242 ENOG4105C0D helicase VEA_003253 ENOG4105DFP Integrase VEA_003284 ENOG4108KU3 Integrase VEA_003288 ENOG4105VZ1 Replication Protein VEA_003289 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) VEA_003290 ENOG4105C4R Atp-dependent dna helicase VEA_003294 ENOG4105KEG ribosomal-protein-alanine acetyltransferase VEA_003301 ENOG4105KNA -acetyltransferase VEA_003302 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) VEA_003305 ENOG4105KCV RNA signal recognition particle 4.5S RNA VEA_003307 ENOG4105N14 lysine exporter protein LysE YggA VEA_003308 ENOG41090VV Protein of unknown function (DUF2846) VEA_003310 ENOG4105Y49 secretion protein, HlyD family VEA_003312 ENOG4105EQ2 LysR family Transcriptional regulator VEA_003314 ENOG4105Y49 secretion protein, HlyD family VEA_003317 ENOG4107KET secretion protein, HlyD family VEA_003319 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism VEA_003320 ENOG4108V9W transcriptional regulatory protein VEA_003322 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF VEA_003323 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase VEA_003324 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) VEA_003325 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) VEA_003329 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family VEA_003330 ENOG4105C26 Dehydrogenase VEA_003334 ENOG4108KB1 transcriptional regulator, arac family VEA_003340 ENOG41066XE Type III export protein VEA_003356 ENOG4105CW7 secretion protein, HlyD family VEA_003358 ENOG41062JF Transcriptional regulator VEA_003380 ENOG4105EJ9 Membrane VEA_003388 ENOG4105CR4 methylisocitrate lyase VEA_003389 ENOG4105BZN citrate synthase VEA_003390 ENOG4108I0Z Aconitate hydratase VEA_003391 ENOG4105C7F AcnD-accessory protein PrpF VEA_003392 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) VEA_003394 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap VEA_003397 ENOG410667J hydrolase VEA_003398 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) VEA_003399 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) VEA_003400 ENOG4105BZU Histidine kinase VEA_003402 ENOG4105CDV Ompa motb domain protein VEA_003405 ENOG4105CDV Ompa motb domain protein VEA_003408 ENOG4105DR4 Methyltransferase VEA_003409 ENOG4105C8Q Methyl-accepting chemotaxis VEA_003410 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 VEA_003411 ENOG4108Z0T Part of a sulfur-relay system (By similarity) VEA_003413 ENOG4108MN8 Membrane VEA_003414 ENOG4105CDA abc transporter atp-binding protein VEA_003415 ENOG4105DRP amino acid AbC transporter VEA_003416 ENOG4105EZ7 amino acid ABC transporter VEA_003418 ENOG4107QXX ABC transporter VEA_003420 ENOG4108VPT UPF0234 protein VEA_003421 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) VEA_003425 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B VEA_003426 ENOG4105DY2 Paraquat-inducible protein b VEA_003427 ENOG4105H2K paraquat-inducible protein a VEA_003428 ENOG4105BZ1 (ABC) transporter VEA_003429 ENOG4108ZGC gaf domain protein VEA_003430 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) VEA_003431 ENOG4105CN1 protease VEA_003433 ENOG4105CD8 aminopeptidase N VEA_003435 ENOG4105C7I Dehydrogenase VEA_003436 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) VEA_003437 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) VEA_003438 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) VEA_003440 ENOG4105C5H ABC transporter VEA_003443 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) VEA_003444 ENOG4105DAN ATP-dependent protease VEA_003445 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) VEA_003461 ENOG4105VZ1 Replication Protein VEA_003464 ENOG4105BZU Histidine kinase VEA_003467 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i VEA_003470 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) VEA_003472 ENOG4105C59 p-type ATPase VEA_003475 ENOG4105DS0 Transcriptional regulator, Crp Fnr family VEA_003476 ENOG4105Q9Y Universal stress protein VEA_003477 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) VEA_003481 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) VEA_003482 ENOG4105F38 ABC transporter, permease VEA_003483 ENOG4105D38 putrescine abc transporter VEA_003484 ENOG4107RUE extracellular solute-binding protein family 1 VEA_003485 ENOG4107RUE extracellular solute-binding protein family 1 VEA_003486 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) VEA_003493 ENOG4105QAX Iron-sulfur VEA_003494 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) VEA_003496 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) VEA_003500 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) VEA_003501 ENOG4105C5H ABC transporter VEA_003502 ENOG4105BZU Histidine kinase VEA_003503 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VEA_003506 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) VEA_003507 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) VEA_003508 ENOG4105CVM Molybdenum cofactor synthesis domain protein VEA_003510 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) VEA_003511 ENOG4106IUH DTW domain containing protein VEA_003516 ENOG4105C8Q Methyl-accepting chemotaxis VEA_003517 ENOG4108QBX (LipO)protein VEA_003519 ENOG4105BZU Histidine kinase VEA_003521 ENOG4105FGM Fructosamine kinase VEA_003523 ENOG4108R6K riboflavin synthase, subunit alpha VEA_003524 ENOG4107QI1 Mate efflux family protein VEA_003528 ENOG41082AN stage II sporulation protein VEA_003530 ENOG4107V1M polysaccharide export protein VEA_003533 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VEA_003535 ENOG4107TYR Glycosyl Transferase VEA_003541 ENOG4105CPK Glycosyl transferase (Group 1 VEA_003542 ENOG4107R8N Glycosyl transferase, family 2 VEA_003545 ENOG4105C94 Transporter VEA_003548 ENOG4105CQ7 ATP-dependent helicase VEA_003549 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) VEA_003558 ENOG4105CFG Acts as a chaperone (By similarity) VEA_003559 ENOG4105CFG Acts as a chaperone (By similarity) VEA_003563 ENOG4106855 Competence protein VEA_003564 ENOG4105BZ1 (ABC) transporter VEA_003565 ENOG4105BZ1 (ABC) transporter VEA_003567 ENOG4105E0K tonB-dependent siderophore receptor VEA_003568 ENOG4105S6R Iron-hydroxamate transporter permease subunit VEA_003569 ENOG4105J76 Periplasmic binding protein VEA_003570 ENOG4105E0A ABC, transporter VEA_003572 ENOG4105CPI Metal Dependent Phosphohydrolase VEA_003573 ENOG4105E0U tyrosine-specific transport protein VEA_003575 ENOG4105DHT Metal Dependent Phosphohydrolase VEA_003577 ENOG4105EE5 Membrane protein terC VEA_003579 ENOG41076CZ activating enzyme VEA_003580 ENOG4105G0K glycine radical enzyme YjjI family VEA_003581 ENOG410829K Lysine exporter protein (Lyse ygga) VEA_003582 ENOG4105CPI Metal Dependent Phosphohydrolase VEA_003583 ENOG4105BZU Histidine kinase VEA_003584 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VEA_003586 ENOG4105C8P )-transporter VEA_003591 ENOG4105BZU Histidine kinase VEA_003593 ENOG41090KN UPF0303 protein VEA_003594 ENOG4105D9R oxidoreductase VEA_003595 ENOG4105E98 transcriptional regulator DeoR family VEA_003598 ENOG4105C4X radical SAM domain protein VEA_003601 ENOG4105ENH Sulfatase VEA_003602 ENOG4105CZK Aspartate kinase VEA_003603 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) VEA_003604 ENOG4108JPW Aminotransferase VEA_003605 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase VEA_003606 ENOG4105C94 Transporter VEA_003609 ENOG4108IJ7 Glycine betaine VEA_003610 ENOG4108HQS Glycine betaine VEA_003611 ENOG4105GIJ Glycine betaine VEA_003613 ENOG4108IQE Amp-dependent synthetase and ligase VEA_003618 ENOG4105DHQ Histidine kinase VEA_003619 ENOG4105E0M Sulfatase VEA_003625 ENOG4105BZG amino acid carrier protein VEA_003627 ENOG410829K Lysine exporter protein (Lyse ygga) VEA_003628 ENOG4105CTD carboxy-peptidase VEA_003629 ENOG4105D1S lipid A biosynthesis VEA_003630 ENOG4105E5D amino acid VEA_003633 ENOG4105CVG Homoserine O-transsuccinylase VEA_003634 ENOG41090FY type IV pilus biogenesis stability protein PilW VEA_003636 ENOG4105BZU Histidine kinase VEA_003637 ENOG4105BZU Histidine kinase VEA_003640 ENOG4108UW5 maltose o-acetyltransferase VEA_003643 ENOG4105MSB protein, conserved in bacteria VEA_003644 ENOG4108ZT1 Transcriptional regulator VEA_003646 ENOG4105CXC rtn protein VEA_003652 ENOG4108RXX maleylacetoacetate isomerase VEA_003654 ENOG4105F1J Homogentisate 1,2-dioxygenase VEA_003655 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase VEA_003656 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) VEA_003657 ENOG4107QSI ABC, transporter VEA_003658 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component VEA_003659 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VEA_003660 ENOG4105C3U ABC transporter VEA_003661 ENOG4108JQ7 (ABC) transporter VEA_003663 ENOG4107MM9 BNR Asp-box repeat-containing protein VEA_003666 ENOG4105D38 putrescine abc transporter VEA_003667 ENOG4105F38 ABC transporter, permease VEA_003668 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) VEA_003669 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) VEA_003670 ENOG4105CIF Ornithine Cyclodeaminase VEA_003673 ENOG4105CTU Proline racemase VEA_003679 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) VEA_003680 ENOG4108VKG metal-dependent hydrolase VEA_003682 ENOG4105F04 LysR family Transcriptional regulator VEA_003686 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) VEA_003687 ENOG4108IU2 vtamin B12-transporter permease VEA_003688 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) VEA_003692 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) VEA_003693 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) VEA_003694 ENOG4105K4T epimerase VEA_003695 ENOG4108ETY sodium dicarboxylate symporter VEA_003696 ENOG4105CJB Exodeoxyribonuclease I VEA_003697 ENOG4105VAW lrga family VEA_003698 ENOG41067MG lrgb family VEA_003699 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) VEA_003700 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR VEA_003701 ENOG4105FQ6 thiopurine methyltransferase VEA_003703 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) VEA_003705 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) VEA_003706 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) VEA_003712 ENOG4105K8R UPF0145 protein VEA_003713 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) VEA_003714 ENOG41082NX 50s ribosomal protein l35 VEA_003715 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) VEA_003716 ENOG4105C22 threonyL-tRNA synthetase VEA_003719 ENOG4105CZE histidine utilization repressor VEA_003720 ENOG4105CI2 imidazolone-5-propionate hydrolase VEA_003721 ENOG41088SP formiminoglutamate hydrolase VEA_003723 ENOG4105C84 Histidine ammonia-lyase VEA_003726 ENOG4105CQB FAD linked oxidase domain protein VEA_003729 ENOG4105CDV Ompa motb domain protein VEA_003733 ENOG4105C8V SAICAR synthetase VEA_003736 ENOG4105CQ7 ATP-dependent helicase VEA_003737 ENOG4107R1I NAD-dependent malic enzyme VEA_003738 ENOG4107GZ4 SanA protein VEA_003739 ENOG4105C8P )-transporter VEA_003740 ENOG4105BZU Histidine kinase VEA_003744 ENOG4105C3M thioredoxin reductase VEA_003745 ENOG4108JJ9 ABC, transporter VEA_003746 ENOG4108JJ8 (ABC) transporter VEA_003747 ENOG4105BZC d-serine deaminase VEA_003748 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) VEA_003750 ENOG4105BZU Histidine kinase VEA_003756 ENOG4105DWU Membrane VEA_003759 ENOG4105DY8 decarboxylase VEA_003760 ENOG4106KNT transcriptional regulator VEA_003762 ENOG41090BQ Glutaredoxin VEA_003763 ENOG4105D0C transport protein VEA_003764 ENOG4105RKW reductase (By VEA_003765 ENOG4107QPN acyl-Coa dehydrogenase VEA_003766 ENOG41067SE Tetr family transcriptional regulator VEA_003767 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) VEA_003772 ENOG4107QI1 Mate efflux family protein VEA_003773 ENOG4105CGD Nad-dependent epimerase dehydratase VEA_003774 ENOG4105CUW cytochrome C-TYPE protein VEA_003780 ENOG4105C2C drug resistance transporter, Bcr CflA VEA_003781 ENOG4105I08 Pseudouridine synthase VEA_003782 ENOG4105CFI type iii restriction protein res subunit VEA_003784 ENOG4105ETX regulatoR VEA_003785 ENOG4105EB3 Histidine kinase VEA_003787 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) VEA_003789 ENOG4105CGH 5'-nucleotidase VEA_003791 ENOG4105XZD Fe-S protein VEA_003793 ENOG4105VNH ABC transporter solute-binding protein VEA_003794 ENOG4105CXZ ABC transporter, permease VEA_003795 ENOG4108VGW abc transporter atp-binding protein VEA_003796 ENOG4108T9J Cdp-alcohol phosphatidyltransferase VEA_003798 ENOG4108JUA Transcriptional regulator VEA_003799 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) VEA_003800 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) VEA_003802 ENOG4108W1A pseudouridine synthase VEA_003803 ENOG4105C8J )-transporter VEA_003804 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) VEA_003805 ENOG4105C28 cystathionine VEA_003806 ENOG4107IFA Lipase (EC 3.1.1.3) VEA_003808 ENOG4108R3E Dna-3-methyladenine glycosylase i VEA_003812 ENOG4105FM1 phage shock protein C VEA_003813 ENOG4105YYT phage shock protein B VEA_003814 ENOG41087YS Phage shock protein A VEA_003815 ENOG4105E51 psp operon transcriptional activator VEA_003816 ENOG4108J59 Extracellular solute-binding protein, family 5 VEA_003817 ENOG4108I5W peptide transport system, permease protein VEA_003818 ENOG4108EU3 peptide transport system, permease VEA_003819 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein VEA_003820 ENOG4108JQ2 peptide transport system atp-binding protein VEA_003822 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase VEA_003825 ENOG4108J2R molybdopterin oxidoreductase VEA_003830 ENOG4105TMB Formate nitrite transporter VEA_003835 ENOG4107DB1 DUF218 domain VEA_003836 ENOG4107104 thymidine kinase VEA_003837 ENOG4105C8N cysteinyl-tRNA synthetase VEA_003838 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) VEA_003839 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) VEA_003840 ENOG4105D58 Diguanylate phosphodiesterase VEA_003841 ENOG4105K5B UPF0225 protein VEA_003846 ENOG4105ECC imidazole-glycerol-phosphate dehydratase VEA_003847 ENOG4105CIH Imidazole acetol-phosphate transaminase VEA_003848 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) VEA_003849 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) VEA_003850 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VEA_003851 ENOG4107S6Z Na H antiporter VEA_003852 ENOG4108YX2 DNA-binding protein VEA_003853 ENOG4107RE1 Inosine-guanosine kinase VEA_003855 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) VEA_003856 ENOG41075W9 High frequency lysogenization protein HflD homolog VEA_003857 ENOG4107QTF adenylosuccinate lyase VEA_003859 ENOG4105RHG VEA_003861 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase VEA_003864 ENOG4107FW0 short-chain dehydrogenase reductase VEA_003866 ENOG4105D0M Protease HtpX homolog VEA_003868 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) VEA_003869 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) VEA_003870 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) VEA_003871 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) VEA_003876 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) VEA_003877 ENOG4105D1H recombination factor protein RarA VEA_003878 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) VEA_003879 ENOG4105CNU cell division protein FtsK VEA_003880 ENOG4105EW9 transcriptional regulator AsnC family VEA_003881 ENOG4105DCF alanine dehydrogenase VEA_003883 ENOG4107R11 Transcriptional regulator VEA_003885 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase VEA_003886 ENOG4105C8Q Methyl-accepting chemotaxis VEA_003894 ENOG4105BZS acriflavin resistance protein VEA_003895 ENOG4105C1P efflux transporter, rnd family, mfp subunit VEA_003896 ENOG4105C8Q Methyl-accepting chemotaxis VEA_003899 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) VEA_003903 ENOG4108RNS Exports L-alanine (By similarity) VEA_003904 ENOG4105BZU Histidine kinase VEA_003906 ENOG4106032 Glutathionylspermidine synthase VEA_003908 ENOG4105Z6B inner membrane protein yjfl VEA_003910 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) VEA_003911 ENOG4105UFD tol-pal system protein YbgF VEA_003912 ENOG4105KCK Peptidoglycan-associated lipoprotein VEA_003913 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) VEA_003915 ENOG4105M8F Biopolymer transport protein exbD tolR VEA_003916 ENOG4105E02 MotA TolQ exbB proton channel VEA_003917 ENOG4107YD3 Thioesterase VEA_003920 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii VEA_003921 ENOG4105C4M (Ubiquinol oxidase) subunit I VEA_003922 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) VEA_003923 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) VEA_003924 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) VEA_003925 ENOG4105CDY transcriptional regulatory protein VEA_003926 ENOG4105C9M aspartyl-trna synthetase VEA_003927 ENOG41081XQ Conserved Protein VEA_003928 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) VEA_003929 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) VEA_003930 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) VEA_003934 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) VEA_003935 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) VEA_003936 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) VEA_003937 ENOG4106371 Methyltransferase VEA_003938 ENOG4107S90 membrAne VEA_003939 ENOG4106WF9 DNA-binding transcriptional regulator TorR VEA_003940 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) VEA_003941 ENOG4105ETE Transcriptional regulator (LacI family VEA_003942 ENOG4105HP8 regulator of competence-specific genes VEA_003946 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) VEA_003947 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) VEA_003948 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) VEA_003950 ENOG4105RKX Protein of unknown function (DUF2498) VEA_003951 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase VEA_003953 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) VEA_003954 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate VEA_003955 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) VEA_003956 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit VEA_003957 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) VEA_003958 ENOG4105VEQ Cold shock protein VEA_003960 ENOG4108R99 pseudouridine synthase VEA_003962 ENOG4105SDR Outer membrane protein OmpT VEA_003963 ENOG4105DVT helicase VEA_003964 ENOG4105EJ9 Membrane VEA_003965 ENOG4108URS primosomal replication protein n'' VEA_003966 ENOG4106428 Protein of unknown function (DUF2496) VEA_003967 ENOG4105CGK Exodeoxyribonuclease III VEA_003971 ENOG4105DSP amino acid AbC transporter VEA_003972 ENOG4105E89 ABC transporter VEA_003973 ENOG4108JEH abc transporter atp-binding protein VEA_003976 ENOG4105C6N Formate acetyltransferase VEA_003978 ENOG4105F1A Pyruvate formate-lyase VEA_003980 ENOG4105XWI UPF0304 protein VEA_003981 ENOG4105CYN Serine protein kinase VEA_003982 ENOG4106AKX UPF0229 protein VEA_003983 ENOG4105ED1 spovr family VEA_003984 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) VEA_003985 ENOG4105W49 UPF0434 protein VEA_003986 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) VEA_003987 ENOG4105BZ1 (ABC) transporter VEA_003988 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 VEA_003990 ENOG4105D60 lipoprotein releasing system transmembrane protein VEA_003991 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) VEA_003992 ENOG4105D60 lipoprotein releasing system transmembrane protein VEA_003994 ENOG4108JA2 transcriptioN-repair coupling factor VEA_003997 ENOG4105CEP NADH dehydrogenase VEA_003998 ENOG4105D0Y UPF0227 protein VEA_004003 ENOG4105K59 histidine triad (HIT) protein VEA_004004 ENOG4108NVR Methyl-accepting chemotaxis VEA_004006 ENOG4107SXA Phosphorylase VEA_004008 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) VEA_004010 ENOG4105BZU Histidine kinase VEA_004013 ENOG4108MNP Glycoprotein polysaccharide metabolism VEA_004014 ENOG4105C29 acyl-CoA thioesterase VEA_004016 ENOG4108XM1 transcriptional regulator AsnC family VEA_004021 ENOG4105BZS acriflavin resistance protein VEA_004022 ENOG4105EP1 Efflux transporter rnd family, mfp subunit VEA_004025 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) VEA_004026 ENOG4105HMI Membrane VEA_004028 ENOG4105CEY Amp-dependent synthetase and ligase VEA_004029 ENOG4105DNI Converts SHCHC to OSB (By similarity) VEA_004030 ENOG4108IPT Naphthoate synthase VEA_004031 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) VEA_004032 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) VEA_004033 ENOG4105E4F Isochorismate synthase VEA_004034 ENOG4105CHM Aminotransferase VEA_004035 ENOG4105DK2 UPF0207 protein VEA_004036 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein VEA_004039 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein VEA_004040 ENOG4105EIN peptidylprolyl cis-trans isomerase VEA_004041 ENOG4105K70 DNA-binding protein VEA_004042 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) VEA_004043 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) VEA_004044 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) VEA_004045 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation VEA_004046 ENOG4105CQZ Histidine kinase VEA_004047 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VEA_004048 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VEA_004049 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ VEA_004050 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit VEA_004051 ENOG4105CNG UPF0061 protein VEA_004055 ENOG4107ZYR domain protein VEA_004056 ENOG4105C1J atp-dependent rna helicase VEA_004064 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) VEA_004068 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) VEA_004069 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) VEA_004070 ENOG4105C84 Histidine ammonia-lyase VEA_004075 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) VEA_004076 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) VEA_004077 ENOG4105C2D reductase VEA_004078 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) VEA_004081 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) VEA_004082 ENOG4105D9N nucleoside VEA_004084 ENOG4105CVE Lytic murein transglycosylase VEA_004085 ENOG4105VNG YcgL domain-containing protein VEA_004086 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) VEA_004087 ENOG4107QMS site-determining protein VEA_004088 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) VEA_004089 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) VEA_004090 ENOG4105CEY Amp-dependent synthetase and ligase VEA_004091 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) VEA_004092 ENOG4105R8X Outer membrane lipoprotein Slp VEA_004094 ENOG41072GX Peptidase M22 Glycoprotease VEA_004095 ENOG4105DVT helicase VEA_004096 ENOG4105CIY formyltetrahydrofolate deformylase VEA_004097 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap VEA_004099 ENOG4106ZCM YecM protein VEA_004100 ENOG4105C75 arginyL-tRNA synthetase VEA_004104 ENOG4105XFK Ferrous iron transport protein A VEA_004105 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) VEA_004106 ENOG4105NXV High-affinity zinc uptake system protein VEA_004107 ENOG4105FDK ABC transporter VEA_004108 ENOG4105FAV ABC, transporter VEA_004109 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha VEA_004110 ENOG4105CMV Succinyl-CoA synthetase subunit beta VEA_004111 ENOG4105C7S Dehydrogenase VEA_004112 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 VEA_004113 ENOG4105E33 succinate dehydrogenase VEA_004114 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) VEA_004115 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein VEA_004116 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit VEA_004117 ENOG4105BZN citrate synthase VEA_004118 ENOG4107QNR UPF0135 protein VEA_004120 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 VEA_004121 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) VEA_004122 ENOG4105EV9 Alpha Beta Hydrolase VEA_004124 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) VEA_004126 ENOG41090R7 Ferric uptake VEA_004127 ENOG4105CX6 glutaminyL-tRNA synthetase VEA_004129 ENOG4105CE4 GlcNAc 6-P deacetylase VEA_004130 ENOG4105E2R ROK family VEA_004131 ENOG4105CKD glutathione-regulated potassium-efflux system protein VEA_004132 ENOG4105CAQ asparagine synthetase VEA_004133 ENOG4105MDZ Transcriptional activator rfaH VEA_004134 ENOG4105DUX Transporter VEA_004135 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) VEA_004136 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) VEA_004137 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) VEA_004138 ENOG4108DQ1 activator toxR VEA_004142 ENOG4108RE9 Phosphodiesterase VEA_004147 ENOG4105ECP epimerase VEA_004148 ENOG4105E1F short-chain dehydrogenase reductase VEA_004149 ENOG4107QR8 Thioredoxin VEA_004150 ENOG4107QX8 SPFH domain, Band 7 family protein VEA_004153 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) VEA_004154 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) VEA_004155 ENOG4105EXN Sulfate transport protein CysZ VEA_004156 ENOG4105C6T cysteine synthase VEA_004157 ENOG4105KZ7 phosphocarrier protein hpr VEA_004158 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) VEA_004159 ENOG4105C5Y PTS System VEA_004161 ENOG4105I03 Flagellin VEA_004162 ENOG4105I03 Flagellin VEA_004163 ENOG4105DTJ flagellar hook-associated protein VEA_004165 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj VEA_004166 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) VEA_004167 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) VEA_004168 ENOG4105CGA flagellar basal-body rod protein FlgG VEA_004169 ENOG4108KPB Flagellar basal-body rod protein FlgF VEA_004170 ENOG4105BZE flagellar hook protein, FlgE VEA_004171 ENOG4105W00 Flagellar hook capping protein VEA_004172 ENOG4108ZC9 flagellar basal-body rod protein flgc VEA_004173 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) VEA_004174 ENOG4105BZU Histidine kinase VEA_004175 ENOG4107R88 Chemotaxis protein (CheV) VEA_004183 ENOG4105UYK outer membrane protein a VEA_004184 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) VEA_004186 ENOG41081QG Porin Gram-negative type VEA_004188 ENOG4105C59 p-type ATPase VEA_004191 ENOG4105E2D ec 3.2.1.52 VEA_004195 ENOG4108DG9 Smr protein MutS2 VEA_004196 ENOG4105FE9 pseudouridine synthase VEA_004197 ENOG4108Z66 YbaK ebsC protein VEA_004198 ENOG4105CGH 5'-nucleotidase VEA_004199 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase VEA_004200 ENOG41063JG Transcriptional regulator VEA_004201 ENOG4108YY7 Invasion gene expression up-regulator SirB VEA_004202 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) VEA_004203 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) VEA_004204 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) VEA_004205 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) VEA_004206 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) VEA_004207 ENOG4105C5T Phosphoribosyl pyrophosphate synthase VEA_004208 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) VEA_004209 ENOG4105C3G gtp-binding protein VEA_004210 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family VEA_004211 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) VEA_004212 ENOG4105C9A Phoh family VEA_004213 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) VEA_004214 ENOG4108JU5 Magnesium and cobalt efflux protein VEA_004215 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) VEA_004216 ENOG4107PAI alpha helical protein VEA_004217 ENOG4105C8T Leucyl-tRNA synthetase VEA_004218 ENOG4108U2H Rare lipoprotein B VEA_004219 ENOG4105DJF DNA polymerase III, delta' subunit VEA_004220 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) VEA_004221 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) VEA_004222 ENOG4105CJN penicillin-binding protein VEA_004223 ENOG4105CNI cell division protein FtsW VEA_004224 ENOG4105K6T rare lipoprotein A VEA_004225 ENOG4105DZ1 carboxypeptidase VEA_004226 ENOG4108Z43 UPF0250 protein VEA_004227 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) VEA_004228 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) VEA_004230 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) VEA_004231 ENOG4108JYZ YitT family VEA_004234 ENOG4105CG3 alpha amylase, catalytic region VEA_004235 ENOG4105C5Y PTS System VEA_004236 ENOG4105D4X repressor VEA_004237 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase VEA_004238 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) VEA_004239 ENOG4108UMI ABC transporter, permease VEA_004240 ENOG4105D01 (LipO)protein VEA_004241 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein VEA_004242 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) VEA_004244 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) VEA_004246 ENOG4105BZU Histidine kinase VEA_004247 ENOG4105EWT decarboxylase family VEA_004248 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease VEA_004249 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) VEA_004250 ENOG4105M08 Membrane VEA_004252 ENOG4105ETT transcriptional Regulator, LysR family VEA_004253 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) VEA_004254 ENOG4106VK6 Flagellar motor protein VEA_004255 ENOG4105E14 MotA TolQ exbB proton channel VEA_004256 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) VEA_004257 ENOG4105CTB Polyprenyl synthetase VEA_004258 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) VEA_004259 ENOG4108ZAI phosphatidylglycerophosphatase a VEA_004260 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) VEA_004261 ENOG4107YIM Involved in the transcription termination process (By similarity) VEA_004262 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) VEA_004265 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) VEA_004266 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) VEA_004267 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) VEA_004268 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) VEA_004269 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) VEA_004270 ENOG4108DJV Fermentation respiration switch protein VEA_004271 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) VEA_004272 ENOG4105C7N Xanthine uracil vitamin C permease VEA_004273 ENOG4105CIN aminoacyl-histidine dipeptidase VEA_004277 ENOG4105X58 receptor VEA_004280 ENOG4108ETH Formylglycinamide ribotide synthetase VEA_004281 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) VEA_004282 ENOG4108Z6B deaminase VEA_004283 ENOG4105CFC Transporter VEA_004289 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) VEA_004292 ENOG4105CK2 sodium dicarboxylate symporter VEA_004293 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ VEA_004294 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) VEA_004296 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) VEA_004297 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) VEA_004298 ENOG4105VDB UPF0125 protein VEA_004299 ENOG4108Z1B Cyclase dehydrase VEA_004300 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) VEA_004301 ENOG4105DFP Integrase VEA_004302 ENOG4107RRE RNA-directed DNA polymerase VEA_004310 ENOG410679B prophage CP4-57 regulatory protein alpA VEA_004316 ENOG4105ETT transcriptional Regulator, LysR family VEA_004318 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase VEA_004322 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) VEA_004323 ENOG4108IQK o-acetylhomoserine VEA_004326 ENOG4105MWK D-amino acid dehydrogenase, small subunit VEA_004327 ENOG4105BZG amino acid carrier protein VEA_004328 ENOG4106HK8 GPR1 FUN34 yaaH family protein VEA_004330 ENOG4107S6Z Na H antiporter VEA_004339 ENOG4105DFP Integrase VEA_004340 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) VEA_004341 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) VEA_004342 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) VEA_004345 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) VEA_004346 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) VEA_004347 ENOG4105N21 Membrane VEA_004348 ENOG4105CUT histidyl-tRNA synthetase VEA_004349 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) VEA_004351 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs VEA_004352 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) VEA_004353 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) VEA_004354 ENOG4105WVQ Fe-S assembly protein IscX VEA_004355 ENOG4108ZIT Ferredoxin, 2FE-2S VEA_004356 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB VEA_004357 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) VEA_004358 ENOG4108Z4V iron-sulfur cluster assembly VEA_004359 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins VEA_004360 ENOG4105C3J Cysteine desulfurase VEA_004361 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family VEA_004362 ENOG4105CVS RNA methyltransferase TrmH family, group 1 VEA_004363 ENOG4105ECY inositol monophosphatase VEA_004364 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) VEA_004365 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) VEA_004366 ENOG4105VIE preprotein translocase, subunit YajC VEA_004367 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) VEA_004368 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) VEA_004370 ENOG4105W87 Cbs domain VEA_004371 ENOG4108I9X Isocitrate lyase VEA_004372 ENOG4107QP3 malate synthase g VEA_004373 ENOG4105C5Q Transcriptional regulator VEA_004374 ENOG4105D3R alkyl hydroperoxide reductase VEA_004375 ENOG4106N3A copper homeostasis protein cutc VEA_004376 ENOG4105CSR polyphosphate kinase 2 VEA_004378 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) VEA_004379 ENOG4105E2Z phosphate ABC transporter (Permease VEA_004380 ENOG4105C8U phosphate abc transporter VEA_004381 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) VEA_004382 ENOG4105C9X ppx gppa phosphatase VEA_004384 ENOG4105BZU Histidine kinase VEA_004385 ENOG4105CK6 Two component transcriptional regulator (Winged helix family VEA_004386 ENOG4105DH7 May be involved in recombination (By similarity) VEA_004387 ENOG4105CFP Peptidase U32 VEA_004388 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding VEA_004392 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit VEA_004393 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase VEA_004394 ENOG4105C34 Pseudouridine synthase VEA_004395 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane VEA_004396 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) VEA_004397 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA VEA_004399 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) VEA_004400 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) VEA_004401 ENOG4107SC1 transglycosylase VEA_004402 ENOG4105C5H ABC transporter VEA_004404 ENOG4105E4C Lytic transglycosylase catalytic VEA_004405 ENOG4105EHE chorismate mutase- prephenate dehydrogenase VEA_004406 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) VEA_004407 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) VEA_004408 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) VEA_004409 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate VEA_004413 ENOG4108HRK Histidine kinase VEA_004414 ENOG4108NEV two component transcriptional regulator, LytTR family VEA_004416 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) VEA_004417 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase VEA_004418 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) VEA_004419 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) VEA_004420 ENOG4105DTN riboflavin biosynthesis protein ribF VEA_004421 ENOG4105CJR Integral membrane protein (MviN VEA_004422 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) VEA_004423 ENOG41080HT Transcriptional regulator, arsr family VEA_004424 ENOG41063Z6 transcriptional regulator, lysR family VEA_004427 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) VEA_004428 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) VEA_004429 ENOG4105HF0 Membrane VEA_004430 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase VEA_004431 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) VEA_004432 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) VEA_004434 ENOG4105CPC Aldo Keto reductase VEA_004436 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VEA_004437 ENOG4105CRK lysyL-tRNA synthetase VEA_004438 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) VEA_004439 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) VEA_004440 ENOG4105T95 Thiol disulfide interChange protein VEA_004441 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) VEA_004442 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) VEA_004443 ENOG4105CWM branched-chain amino acid transport system II carrier protein VEA_004444 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) VEA_004445 ENOG4105C1J atp-dependent rna helicase VEA_004446 ENOG4105D1Q UPF0246 protein VEA_004447 ENOG4105BZG amino acid carrier protein VEA_004450 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) VEA_004452 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) VEA_004453 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) VEA_004455 ENOG4105D98 threonine synthase VEA_004456 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) VEA_004459 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) VEA_004461 ENOG41065U4 response regulator VEA_004463 ENOG4105BZU Histidine kinase VEA_004465 ENOG4105N5T Radical SAM Protein VEA_004468 ENOG4105CBC glutamate synthase VEA_004469 ENOG4105BZ8 glutamate synthase VEA_004471 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) VEA_004472 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) VEA_004473 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) VEA_004474 ENOG4105EN6 Membrane VEA_004476 ENOG4105EJ9 Membrane VEA_004478 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain VEA_004479 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain VEA_004481 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) VEA_004482 ENOG4105M6F mutator MutT protein VEA_004483 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving VEA_004485 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) VEA_004486 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) VEA_004487 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) VEA_004488 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) VEA_004489 ENOG4105DFU Cell wall formation (By similarity) VEA_004490 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) VEA_004492 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) VEA_004493 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) VEA_004494 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) VEA_004495 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) VEA_004496 ENOG4105CJN penicillin-binding protein VEA_004497 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) VEA_004498 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) VEA_004500 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) VEA_004502 ENOG41082RQ UPF0102 protein VEA_004503 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) VEA_004504 ENOG4105W4M Transport-associated protein VEA_004505 ENOG4105KB2 stringent starvation protein b VEA_004506 ENOG4107MKT Stringent starvation protein a VEA_004507 ENOG4105EIX cytochrome c1 VEA_004508 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) VEA_004509 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) VEA_004510 ENOG4108UJD 30S ribosomal protein S9 VEA_004511 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) VEA_004512 ENOG4105D6Z AFG1 family ATPase VEA_004513 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III VEA_004514 ENOG4105C0H protease VEA_004515 ENOG4105C0H protease VEA_004516 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) VEA_004517 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) VEA_004518 ENOG4105IPS esterase VEA_004519 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) VEA_004520 ENOG4108SX3 cytoplasmic protein VEA_004521 ENOG41087AY ADP-Ribose pyrophosphatase VEA_004522 ENOG4105DFG type I secretion outer membrane protein VEA_004523 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) VEA_004524 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) VEA_004525 ENOG4105C8Q Methyl-accepting chemotaxis VEA_004527 ENOG4105I7R Adenylate cyclase VEA_004528 ENOG4107IX6 phosphate transport regulator VEA_004529 ENOG4105CJ3 phosphate transporter