locus-tag	class	description
A6E01_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6E01_00020	COG1126	abc transporter atp-binding protein
A6E01_00040	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6E01_00045	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A6E01_00060	COG1192	Involved in chromosome partitioning
A6E01_00065	COG1475	DNA binding
A6E01_00070	COG3312	ion transport
A6E01_00075	COG0356	it plays a direct role in the translocation of protons across the membrane
A6E01_00085	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6E01_00095	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6E01_00100	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6E01_00110	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6E01_00120	COG0765	amino acid transport
A6E01_00130	COG2814	Major facilitator Superfamily
A6E01_00135	COG0583	DNA-binding transcription factor activity
A6E01_00145	COG0129	dihydroxy-acid dehydratase activity
A6E01_00150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6E01_00155	COG3978	acetolactate synthase activity
A6E01_00165	COG0606	chelatase, subunit chli
A6E01_00170	COG0204	Acyl-transferase
A6E01_00175	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6E01_00180	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A6E01_00190	COG3084	Protein conserved in bacteria
A6E01_00195	COG4326	sporulation control protein
A6E01_00200	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6E01_00205	COG0569	domain protein
A6E01_00210	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6E01_00210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6E01_00225	COG0758	DNA mediated transformation
A6E01_00235	COG0551	DNA topoisomerase type I activity
A6E01_00240	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A6E01_00245	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A6E01_00250	COG0009	L-threonylcarbamoyladenylate synthase
A6E01_00270	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A6E01_00315	COG3071	HemY protein
A6E01_00320	COG2959	enzyme of heme biosynthesis
A6E01_00340	COG1965	Belongs to the frataxin family
A6E01_00345	COG0019	diaminopimelate decarboxylase activity
A6E01_00350	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A6E01_00365	COG1011	Hydrolase
A6E01_00380	COG0561	phosphatase activity
A6E01_00385	COG2267	carboxylic ester hydrolase activity
A6E01_00390	COG1280	lysine exporter protein (LysE YggA)
A6E01_00395	COG0640	Transcriptional regulator
A6E01_00400	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6E01_00440	COG0747	negative chemotaxis
A6E01_00450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6E01_00460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6E01_00465	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A6E01_00470	COG0339	signal peptide processing
A6E01_00475	COG1522	sequence-specific DNA binding
A6E01_00480	COG0742	ribosomal rna small subunit methyltransferase
A6E01_00490	COG0589	response to stress
A6E01_00495	COG1528	Iron-storage protein
A6E01_00505	COG2081	HI0933 family
A6E01_00530	COG4608	Belongs to the ABC transporter superfamily
A6E01_00535	COG0444	Belongs to the ABC transporter superfamily
A6E01_00550	COG4166	transmembrane transport
A6E01_00565	COG2226	methyltransferase
A6E01_00580	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6E01_00585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6E01_00590	COG0805	protein transport
A6E01_00595	COG0084	hydrolase, TatD family'
A6E01_00610	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6E01_00610	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6E01_00615	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A6E01_00645	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6E01_00655	COG3852	Histidine kinase
A6E01_00660	COG0174	glutamine synthetase
A6E01_00680	COG0456	acetyltransferase
A6E01_00700	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A6E01_00705	COG3031	protein transport across the cell outer membrane
A6E01_00715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6E01_00720	COG1459	type II secretion system
A6E01_00725	COG2165	general secretion pathway protein
A6E01_00730	COG2165	general secretion pathway protein
A6E01_00735	COG2165	general secretion pathway protein
A6E01_00740	COG4795	General secretion pathway protein
A6E01_00745	COG3156	type II secretion system protein K
A6E01_00750	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
A6E01_00755	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
A6E01_00765	COG0494	nUDIX hydrolase
A6E01_00770	COG1218	3'(2'),5'-bisphosphate nucleotidase
A6E01_00780	COG1040	competence protein
A6E01_00795	COG0745	RESPONSE REGULATOR receiver
A6E01_00800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6E01_00805	COG4067	protein conserved in archaea
A6E01_00805	COG0189	ligase activity
A6E01_00810	COG2183	response to ionizing radiation
A6E01_00815	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6E01_00825	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6E01_00845	COG0438	transferase activity, transferring glycosyl groups
A6E01_00855	COG0859	PFAM glycosyl transferase family 9
A6E01_00860	COG3642	lipopolysaccharide core region biosynthetic process
A6E01_00865	COG1519	Transferase
A6E01_00875	COG0438	transferase activity, transferring glycosyl groups
A6E01_00890	COG1086	Polysaccharide biosynthesis protein
A6E01_00895	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6E01_00900	COG1083	cytidylyl-transferase
A6E01_00910	COG2089	acid synthase
A6E01_00925	COG0859	PFAM glycosyl transferase family 9
A6E01_00930	COG3307	-O-antigen
A6E01_00935	COG1560	Kdo2-lipid A biosynthetic process
A6E01_00970	COG1609	Transcriptional regulator
A6E01_00975	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6E01_00985	COG0281	malic enzyme
A6E01_00995	COG0626	cystathionine gamma-synthase activity
A6E01_01000	COG0460	homoserine dehydrogenase
A6E01_01000	COG0527	aspartate kinase activity
A6E01_01005	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A6E01_01010	COG1695	Transcriptional regulator
A6E01_01025	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A6E01_01030	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6E01_01040	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A6E01_01040	COG0165	Argininosuccinate lyase
A6E01_01045	COG0251	oxidation-reduction process
A6E01_01050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6E01_01055	COG0678	peroxiredoxin activity
A6E01_01055	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6E01_01060	COG0583	DNA-binding transcription factor activity
A6E01_01065	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A6E01_01105	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A6E01_01110	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A6E01_01115	COG0546	phosphoglycolate phosphatase activity
A6E01_01120	COG0180	Tryptophanyl-tRNA synthetase
A6E01_01140	COG1012	belongs to the aldehyde dehydrogenase family
A6E01_01155	COG3954	Phosphoribulokinase
A6E01_01165	COG0429	hydrolase of the alpha beta-hydrolase fold
A6E01_01175	COG0488	(ABC) transporter
A6E01_01180	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6E01_01195	COG1047	Peptidyl-prolyl cis-trans
A6E01_01200	COG1446	asparaginase
A6E01_01205	COG2900	Belongs to the SlyX family
A6E01_01210	COG0545	Peptidyl-prolyl cis-trans isomerase
A6E01_01215	COG2964	Protein conserved in bacteria
A6E01_01225	COG2923	Belongs to the DsrF TusC family
A6E01_01245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6E01_01255	COG0051	transcription antitermination factor activity, RNA binding
A6E01_01285	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A6E01_01295	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A6E01_01310	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A6E01_01320	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A6E01_01335	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A6E01_01345	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A6E01_01360	COG0201	protein transport
A6E01_01370	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A6E01_01375	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A6E01_01390	COG0203	ribosomal protein L17
A6E01_01405	COG0545	Peptidyl-prolyl cis-trans isomerase
A6E01_01410	COG3266	domain, Protein
A6E01_01410	COG3061	Opacity-associated protein A
A6E01_01420	COG1648	precorrin-2 dehydrogenase activity
A6E01_01420	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6E01_01445	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
A6E01_01450	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6E01_01455	COG0729	surface antigen
A6E01_01465	COG2105	PFAM AIG2 family protein
A6E01_01470	COG3040	lipid binding
A6E01_01475	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A6E01_01480	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6E01_01485	COG0163	prenyltransferase activity
A6E01_01490	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A6E01_01500	COG0564	pseudouridine synthase activity
A6E01_01505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6E01_01510	COG0589	response to stress
A6E01_01530	COG0039	L-malate dehydrogenase activity
A6E01_01540	COG0142	geranyltranstransferase activity
A6E01_01545	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A6E01_01560	COG1289	transmembrane transporter activity
A6E01_01565	COG3610	response to peptide
A6E01_01570	COG3610	response to peptide
A6E01_01580	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A6E01_01595	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A6E01_01605	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A6E01_01610	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A6E01_01625	COG0066	3-isopropylmalate dehydratase activity
A6E01_01635	COG0473	3-isopropylmalate dehydrogenase activity
A6E01_01670	COG0583	DNA-binding transcription factor activity
A6E01_01675	COG1022	Amp-dependent synthetase and ligase
A6E01_01680	COG0028	Belongs to the TPP enzyme family
A6E01_01685	COG0440	acetolactate synthase activity
A6E01_01690	COG0469	pyruvate kinase activity
A6E01_01695	COG0673	inositol 2-dehydrogenase activity
A6E01_01710	COG2015	COG2015, Alkyl sulfatase and related hydrolases
A6E01_01730	COG0534	Mate efflux family protein
A6E01_01755	COG2116	formate transmembrane transporter activity
A6E01_01760	COG1609	Transcriptional regulator
A6E01_01765	COG0129	dihydroxy-acid dehydratase activity
A6E01_01770	COG3265	gluconokinase activity
A6E01_01780	COG0800	Aldolase
A6E01_01785	COG2814	Major facilitator Superfamily
A6E01_01790	COG0583	DNA-binding transcription factor activity
A6E01_01795	COG3448	diguanylate cyclase activity
A6E01_01795	COG4175	Glycine betaine
A6E01_01800	COG4176	ABC-type proline glycine betaine transport system permease component
A6E01_01835	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6E01_01840	COG0358	DNA primase activity
A6E01_01845	COG1610	YqeY-like protein
A6E01_01850	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A6E01_01870	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A6E01_01875	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6E01_01885	COG0617	tRNA 3'-terminal CCA addition
A6E01_01890	COG3267	Type II secretory pathway component ExeA
A6E01_01890	COG3409	Peptidoglycan-binding domain 1 protein
A6E01_01900	COG4991	sh3 domain protein
A6E01_01905	COG0306	phosphate transporter
A6E01_01910	COG1392	Phosphate transport regulator
A6E01_01915	COG3025	triphosphatase activity
A6E01_01930	COG1538	Outer membrane efflux protein
A6E01_01935	COG0494	nUDIX hydrolase
A6E01_01940	COG3151	Protein conserved in bacteria
A6E01_01950	COG3150	esterase
A6E01_01955	COG0187	DNA topoisomerase II activity
A6E01_01965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6E01_01970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6E01_01980	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A6E01_01995	COG0723	plastoquinol--plastocyanin reductase activity
A6E01_02000	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A6E01_02005	COG2857	Cytochrome c1
A6E01_02010	COG0625	glutathione transferase activity
A6E01_02015	COG2969	positive regulation of protein catabolic process
A6E01_02020	COG2823	Periplasmic or secreted lipoprotein
A6E01_02025	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A6E01_02030	COG0792	nuclease activity
A6E01_02035	COG3107	peptidoglycan biosynthetic process
A6E01_02040	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A6E01_02055	COG3116	cell division
A6E01_02060	COG0768	penicillin binding
A6E01_02065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6E01_02070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6E01_02075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6E01_02080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6E01_02085	COG0772	Belongs to the SEDS family
A6E01_02100	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A6E01_02105	COG0849	cell division
A6E01_02110	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A6E01_02130	COG0494	nUDIX hydrolase
A6E01_02140	COG0505	Belongs to the CarA family
A6E01_02145	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A6E01_02150	COG0730	response to heat
A6E01_02155	COG0583	DNA-binding transcription factor activity
A6E01_02160	COG2860	membrane
A6E01_02175	COG0493	'glutamate synthase
A6E01_02180	COG0069	glutamate synthase activity
A6E01_02180	COG0067	glutamate synthase
A6E01_02180	COG0070	glutamate synthase
A6E01_02190	COG0069	glutamate synthase activity
A6E01_02190	COG0070	glutamate synthase
A6E01_02190	COG0067	glutamate synthase
A6E01_02195	COG1242	4 iron, 4 sulfur cluster binding
A6E01_02200	COG0784	Response regulator, receiver
A6E01_02200	COG5002	protein histidine kinase activity
A6E01_02200	COG2198	Histidine kinase
A6E01_02210	COG0745	RESPONSE REGULATOR receiver
A6E01_02225	COG0083	homoserine kinase activity
A6E01_02230	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A6E01_02235	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
A6E01_02245	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6E01_02260	COG1115	amino acid carrier protein
A6E01_02280	COG0513	Belongs to the DEAD box helicase family
A6E01_02295	COG0716	FMN binding
A6E01_02305	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6E01_02310	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A6E01_02315	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A6E01_02320	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A6E01_02325	COG0517	IMP dehydrogenase activity
A6E01_02335	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A6E01_02340	COG0343	queuine tRNA-ribosyltransferase activity
A6E01_02345	COG1862	Preprotein translocase
A6E01_02350	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6E01_02355	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6E01_02360	COG1047	Peptidyl-prolyl cis-trans
A6E01_02365	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A6E01_02370	COG1966	Carbon starvation protein
A6E01_02380	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A6E01_02395	COG3279	Response regulator of the LytR AlgR family
A6E01_02400	COG3275	phosphorelay sensor kinase activity
A6E01_02405	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6E01_02410	COG0287	Prephenate dehydrogenase
A6E01_02410	COG1605	Chorismate mutase
A6E01_02415	COG0488	(ABC) transporter
A6E01_02425	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
A6E01_02430	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
A6E01_02435	COG0077	Prephenate dehydratase
A6E01_02435	COG1605	Chorismate mutase
A6E01_02440	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A6E01_02445	COG1196	nuclear chromosome segregation
A6E01_02445	COG0739	heme binding
A6E01_02445	COG0741	lytic transglycosylase activity
A6E01_02450	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6E01_02455	COG0564	pseudouridine synthase activity
A6E01_02465	COG0542	response to heat
A6E01_02510	COG0697	spore germination
A6E01_02520	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6E01_02530	COG2974	May be involved in recombination
A6E01_02535	COG0745	RESPONSE REGULATOR receiver
A6E01_02540	COG5002	protein histidine kinase activity
A6E01_02550	COG0248	Ppx GppA phosphatase
A6E01_02555	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A6E01_02560	COG0573	inorganic phosphate transmembrane transporter activity
A6E01_02565	COG0573	inorganic phosphate transmembrane transporter activity
A6E01_02575	COG0704	Plays a role in the regulation of phosphate uptake
A6E01_02580	COG3142	Participates in the control of copper homeostasis
A6E01_02585	COG0450	alkyl hydroperoxide reductase
A6E01_02590	COG0583	DNA-binding transcription factor activity
A6E01_02600	COG3066	DNA modification
A6E01_02615	COG0730	response to heat
A6E01_02620	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A6E01_02635	COG1283	sodium-dependent phosphate transmembrane transporter activity
A6E01_02640	COG0583	DNA-binding transcription factor activity
A6E01_02645	COG0640	Transcriptional regulator
A6E01_02655	COG0728	peptidoglycan biosynthetic process
A6E01_02660	COG0196	riboflavin kinase activity
A6E01_02665	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6E01_02670	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A6E01_02675	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6E01_02690	COG0779	Required for maturation of 30S ribosomal subunits
A6E01_02695	COG0195	Participates in both transcription termination and antitermination
A6E01_02715	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A6E01_02740	COG1609	Transcriptional regulator
A6E01_02760	COG3153	acetyltransferase
A6E01_02770	COG0456	acetyltransferase
A6E01_02775	COG1151	hydroxylamine reductase activity
A6E01_02780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6E01_02780	COG1017	nitric oxide dioxygenase activity
A6E01_02790	COG0084	hydrolase, TatD family'
A6E01_02795	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6E01_02820	COG0813	purine-nucleoside phosphorylase activity
A6E01_02830	COG0560	Phosphoserine phosphatase
A6E01_02835	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A6E01_02840	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6E01_02845	COG1022	Amp-dependent synthetase and ligase
A6E01_02850	COG5433	transposase activity
A6E01_02865	COG4974	Belongs to the 'phage' integrase family
A6E01_02910	COG4964	Belongs to the GSP D family
A6E01_02960	COG3250	beta-galactosidase activity
A6E01_02975	COG0534	Mate efflux family protein
A6E01_02985	COG2017	converts alpha-aldose to the beta-anomer
A6E01_02990	COG1175	transmembrane transport
A6E01_02995	COG0395	ABC-type sugar transport system, permease component
A6E01_03005	COG1609	Transcriptional regulator
A6E01_03010	COG1301	dicarboxylic acid transport
A6E01_03015	COG2171	N-acyltransferase activity
A6E01_03020	COG3141	response to X-ray
A6E01_03025	COG0583	DNA-binding transcription factor activity
A6E01_03035	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A6E01_03040	COG1074	ATP-dependent DNA helicase activity
A6E01_03045	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6E01_03050	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A6E01_03050	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6E01_03055	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A6E01_03060	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A6E01_03065	COG2166	iron-sulfur cluster assembly
A6E01_03070	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6E01_03075	COG0693	protein deglycase activity
A6E01_03080	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A6E01_03085	COG3248	Nucleoside-binding outer membrane protein
A6E01_03095	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A6E01_03105	COG1595	DNA-templated transcription, initiation
A6E01_03120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6E01_03135	COG0271	Belongs to the BolA IbaG family
A6E01_03145	COG1805	sodium ion transport
A6E01_03160	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6E01_03165	COG2871	sodium ion transport
A6E01_03170	COG1477	protein flavinylation
A6E01_03175	COG2991	Protein conserved in bacteria
A6E01_03195	COG1278	Cold shock
A6E01_03210	COG0442	prolyl-tRNA aminoacylation
A6E01_03215	COG1720	tRNA m6t6A37 methyltransferase activity
A6E01_03220	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A6E01_03225	COG1464	Belongs to the NlpA lipoprotein family
A6E01_03230	COG2011	ABC-type metal ion transport system permease component
A6E01_03235	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6E01_03240	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6E01_03245	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6E01_03250	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6E01_03255	COG1451	nucleotide metabolic process
A6E01_03270	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A6E01_03275	COG0321	lipoyl(octanoyl) transferase activity
A6E01_03280	COG2921	Belongs to the UPF0250 family
A6E01_03285	COG1686	Belongs to the peptidase S11 family
A6E01_03290	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6E01_03295	COG0772	Belongs to the SEDS family
A6E01_03300	COG0768	penicillin binding
A6E01_03310	COG0799	negative regulation of ribosome biogenesis
A6E01_03315	COG1466	dna polymerase III delta subunit
A6E01_03320	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
A6E01_03325	COG0495	leucyl-tRNA aminoacylation
A6E01_03330	COG2888	peptidyl-tyrosine sulfation
A6E01_03340	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A6E01_03345	COG4535	Mg2 and Co2 transporter CorC
A6E01_03350	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A6E01_03355	COG1702	phosphate starvation-inducible protein PhoH
A6E01_03365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6E01_03460	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A6E01_03465	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A6E01_03470	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A6E01_03480	COG2890	protein-(glutamine-N5) methyltransferase activity
A6E01_03490	COG2912	Transglutaminase-like superfamily
A6E01_03500	COG0737	Belongs to the 5'-nucleotidase family
A6E01_03520	COG1187	pseudouridine synthase activity
A6E01_03525	COG2840	Smr protein MutS2
A6E01_03580	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6E01_03585	COG1085	galactose-1-phosphate uridylyltransferase
A6E01_03600	COG1609	Transcriptional regulator
A6E01_03610	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6E01_03625	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
A6E01_03655	COG3437	response regulator, receiver
A6E01_03665	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6E01_03680	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A6E01_03685	COG0776	regulation of translation
A6E01_03690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6E01_03710	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A6E01_03720	COG0436	Aminotransferase
A6E01_03725	COG1169	isochorismate synthase
A6E01_03730	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A6E01_03735	COG2267	carboxylic ester hydrolase activity
A6E01_03740	COG1441	menaquinone biosynthetic process
A6E01_03755	COG2855	membrane
A6E01_03770	COG0857	belongs to the CobB CobQ family
A6E01_03770	COG0280	phosphate acetyltransferase
A6E01_03775	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A6E01_03790	COG4120	Belongs to the binding-protein-dependent transport system permease family
A6E01_03795	COG1122	ATPase activity
A6E01_03800	COG0366	Alpha amylase catalytic
A6E01_03805	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6E01_03810	COG0653	protein targeting
A6E01_03815	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A6E01_03820	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6E01_03840	COG0587	DNA-directed DNA polymerase activity
A6E01_03870	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A6E01_03875	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6E01_03885	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A6E01_03890	COG0583	DNA-binding transcription factor activity
A6E01_03895	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6E01_03900	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A6E01_03915	COG0583	DNA-binding transcription factor activity
A6E01_03970	COG1953	Uracil, thiamine, allantoin
A6E01_03985	COG0583	DNA-binding transcription factor activity
A6E01_03990	COG2801	Transposase and inactivated derivatives
A6E01_03995	COG2963	transposase activity
A6E01_04000	COG1686	Belongs to the peptidase S11 family
A6E01_04010	COG5433	transposase activity
A6E01_04030	COG3083	sulfuric ester hydrolase activity
A6E01_04045	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6E01_04055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6E01_04060	COG2095	MarC family integral membrane protein
A6E01_04065	COG1012	belongs to the aldehyde dehydrogenase family
A6E01_04065	COG1454	alcohol dehydrogenase
A6E01_04090	COG1028	Short-chain dehydrogenase reductase Sdr
A6E01_04100	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A6E01_04105	COG2056	Na+-H+ antiporter family
A6E01_04115	COG0346	lactoylglutathione lyase activity
A6E01_04120	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6E01_04135	COG4658	electron transport chain
A6E01_04140	COG4656	Part of a membrane complex involved in electron transport
A6E01_04145	COG2878	Part of a membrane complex involved in electron transport
A6E01_04165	COG2204	response regulator
A6E01_04170	COG2198	Histidine kinase
A6E01_04175	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A6E01_04180	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6E01_04185	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6E01_04195	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A6E01_04200	COG0314	molybdopterin synthase activity
A6E01_04210	COG0601	transmembrane transport
A6E01_04215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6E01_04220	COG0444	Belongs to the ABC transporter superfamily
A6E01_04230	COG0435	Glutathione S-transferase
A6E01_04265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6E01_04270	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A6E01_04295	COG1522	sequence-specific DNA binding
A6E01_04300	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6E01_04305	COG1946	Acyl-CoA thioesterase
A6E01_04310	COG3126	Type III secretion system lipoprotein chaperone (YscW)
A6E01_04355	COG3842	ATPase activity
A6E01_04360	COG3459	Glycosyltransferase 36 associated
A6E01_04365	COG1609	Transcriptional regulator
A6E01_04375	COG1175	transmembrane transport
A6E01_04380	COG0395	ABC-type sugar transport system, permease component
A6E01_04400	COG1566	PFAM secretion protein HlyD family protein
A6E01_04420	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6E01_04425	COG0814	amino acid
A6E01_04435	COG0739	heme binding
A6E01_04440	COG2814	Major facilitator Superfamily
A6E01_04445	COG0861	Integral membrane protein TerC family
A6E01_04450	COG1228	amidohydrolase
A6E01_04455	COG0659	secondary active sulfate transmembrane transporter activity
A6E01_04460	COG0589	response to stress
A6E01_04485	COG3344	reverse transcriptase
A6E01_04515	COG2273	Hydrolase Family 16
A6E01_04530	COG0735	belongs to the Fur family
A6E01_04535	COG0625	glutathione transferase activity
A6E01_04540	COG5433	transposase activity
A6E01_04585	COG0488	(ABC) transporter
A6E01_04590	COG3005	denitrification pathway
A6E01_04595	COG0243	molybdopterin cofactor binding
A6E01_04610	COG0583	DNA-binding transcription factor activity
A6E01_04615	COG2814	Major facilitator Superfamily
A6E01_04625	COG2860	membrane
A6E01_04630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6E01_04640	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6E01_04660	COG0583	DNA-binding transcription factor activity
A6E01_04670	COG1346	cytolysis
A6E01_04690	COG5433	transposase activity
A6E01_04695	COG0531	amino acid
A6E01_04720	COG3842	ATPase activity
A6E01_04725	COG0395	ABC-type sugar transport system, permease component
A6E01_04730	COG1175	transmembrane transport
A6E01_04735	COG1653	transport
A6E01_04745	COG1349	DNA-binding transcription factor activity
A6E01_04755	COG0534	Mate efflux family protein
A6E01_04760	COG0444	Belongs to the ABC transporter superfamily
A6E01_04765	COG1124	(ABC) transporter
A6E01_04775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6E01_04780	COG1609	Transcriptional regulator
A6E01_04785	COG4948	Mandelate Racemase Muconate Lactonizing
A6E01_04795	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A6E01_04800	COG3383	formate dehydrogenase (NAD+) activity
A6E01_04815	COG3046	protein related to deoxyribodipyrimidine photolyase
A6E01_04840	COG0672	)-iron permease
A6E01_04845	COG0583	DNA-binding transcription factor activity
A6E01_04850	COG0204	Acyl-transferase
A6E01_04855	COG0110	maltose O-acetyltransferase activity
A6E01_04860	COG2814	Major facilitator Superfamily
A6E01_04865	COG5002	protein histidine kinase activity
A6E01_04870	COG0745	RESPONSE REGULATOR receiver
A6E01_04885	COG4783	chaperone-mediated protein folding
A6E01_04895	COG4604	ABC transporter, ATP-binding protein
A6E01_04900	COG4605	iron ion homeostasis
A6E01_04905	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6E01_04910	COG4607	ABC-type enterochelin transport system periplasmic component
A6E01_04920	COG4771	TonB-dependent receptor
A6E01_04945	COG4109	DRTGG domain
A6E01_04950	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A6E01_04960	COG0537	adenosine 5'-monophosphoramidase activity
A6E01_04985	COG1252	NADH dehydrogenase
A6E01_04995	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6E01_05000	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6E01_05005	COG1136	(ABC) transporter
A6E01_05010	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6E01_05020	COG2333	competence protein COMEC
A6E01_05020	COG0658	competence protein
A6E01_05025	COG1132	(ABC) transporter
A6E01_05030	COG1663	tetraacyldisaccharide 4'-kinase activity
A6E01_05045	COG2719	SpoVR family
A6E01_05050	COG2718	Belongs to the UPF0229 family
A6E01_05055	COG2766	serine protein kinase
A6E01_05065	COG3013	Belongs to the UPF0304 family
A6E01_05070	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6E01_05080	COG1882	Formate acetyltransferase
A6E01_05100	COG4215	(ABC) transporter
A6E01_05105	COG4160	amino acid transport
A6E01_05110	COG0708	Exodeoxyribonuclease III
A6E01_05125	COG0730	response to heat
A6E01_05130	COG1199	ATP-dependent helicase activity
A6E01_05140	COG0297	glycogen (starch) synthase activity
A6E01_05145	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6E01_05165	COG1187	pseudouridine synthase activity
A6E01_05175	COG0531	amino acid
A6E01_05200	COG1278	Cold shock
A6E01_05205	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A6E01_05210	COG0542	response to heat
A6E01_05215	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6E01_05220	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A6E01_05230	COG3134	Outer membrane lipoprotein
A6E01_05240	COG2992	FlgJ-related protein
A6E01_05250	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6E01_05255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6E01_05265	COG1757	Na H antiporter
A6E01_05270	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A6E01_05275	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A6E01_05280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6E01_05285	COG0131	Imidazoleglycerol-phosphate dehydratase
A6E01_05285	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6E01_05290	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A6E01_05295	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A6E01_05305	COG0140	phosphoribosyl-ATP diphosphatase activity
A6E01_05305	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A6E01_05315	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A6E01_05320	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6E01_05325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6E01_05330	COG0215	cysteine-tRNA ligase activity
A6E01_05335	COG1435	thymidine kinase activity
A6E01_05340	COG0189	ligase activity
A6E01_05350	COG4067	protein conserved in archaea
A6E01_05350	COG0189	ligase activity
A6E01_05355	COG0500	methyltransferase
A6E01_05360	COG1227	inorganic diphosphatase activity
A6E01_05365	COG4172	Belongs to the ABC transporter superfamily
A6E01_05375	COG4171	peptide transport system, permease
A6E01_05380	COG4168	peptide transport system, permease
A6E01_05390	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A6E01_05395	COG1842	Phage shock protein A
A6E01_05430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6E01_05460	COG0519	Catalyzes the synthesis of GMP from XMP
A6E01_05470	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A6E01_05475	COG3604	Transcriptional regulator
A6E01_05505	COG4628	conserved protein (DUF2132)
A6E01_05530	COG2850	peptidyl-arginine hydroxylation
A6E01_05540	COG0626	cystathionine gamma-synthase activity
A6E01_05550	COG0564	pseudouridine synthase activity
A6E01_05555	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6E01_05565	COG2350	Protein conserved in bacteria
A6E01_05570	COG1607	acyl-coa hydrolase
A6E01_05575	COG2917	probably involved in intracellular septation
A6E01_05600	COG1028	Short-chain dehydrogenase reductase Sdr
A6E01_05615	COG1301	dicarboxylic acid transport
A6E01_05625	COG0133	tryptophan synthase activity
A6E01_05630	COG0135	phosphoribosylanthranilate isomerase activity
A6E01_05630	COG0134	indole-3-glycerol-phosphate synthase activity
A6E01_05635	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6E01_05640	COG0512	Glutamine amidotransferase of anthranilate synthase
A6E01_05645	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6E01_05650	COG0613	PHP domain protein
A6E01_05655	COG0009	L-threonylcarbamoyladenylate synthase
A6E01_05660	COG1187	pseudouridine synthase activity
A6E01_05665	COG3118	belongs to the thioredoxin family
A6E01_05680	COG0431	NADPH-dependent FMN reductase
A6E01_05705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6E01_05725	COG3085	chromosome segregation
A6E01_05735	COG1132	(ABC) transporter
A6E01_05775	COG3099	Belongs to the UPF0263 family
A6E01_05780	COG0417	DNA replication proofreading
A6E01_05785	COG2197	response regulator
A6E01_05790	COG0322	excinuclease ABC activity
A6E01_05855	COG0019	diaminopimelate decarboxylase activity
A6E01_05860	COG0561	phosphatase activity
A6E01_05865	COG2207	Transcriptional regulator
A6E01_05875	COG3119	arylsulfatase activity
A6E01_05885	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6E01_05890	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6E01_05900	COG2985	domain, Protein
A6E01_05955	COG0277	FAD linked oxidase domain protein
A6E01_05955	COG0247	lactate metabolic process
A6E01_05975	COG0678	peroxiredoxin activity
A6E01_05995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6E01_06000	COG1486	melibiose metabolic process
A6E01_06005	COG0583	DNA-binding transcription factor activity
A6E01_06015	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A6E01_06045	COG2897	thiosulfate sulfurtransferase activity
A6E01_06055	COG2133	pyrroloquinoline quinone binding
A6E01_06075	COG0072	phenylalanine-tRNA ligase activity
A6E01_06075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6E01_06080	COG0513	Belongs to the DEAD box helicase family
A6E01_06085	COG4895	conserved protein (DUF2196)
A6E01_06095	COG2815	serine threonine protein kinase
A6E01_06095	COG0515	serine threonine protein kinase
A6E01_06115	COG4974	Belongs to the 'phage' integrase family
A6E01_06120	COG1247	-acetyltransferase
A6E01_06150	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A6E01_06165	COG1187	pseudouridine synthase activity
A6E01_06185	COG0776	regulation of translation
A6E01_06190	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A6E01_06200	COG1346	cytolysis
A6E01_06210	COG2925	Exonuclease
A6E01_06240	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6E01_06265	COG0673	inositol 2-dehydrogenase activity
A6E01_06280	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6E01_06295	COG1322	Protein conserved in bacteria
A6E01_06300	COG0629	single-stranded DNA binding
A6E01_06320	COG0420	3'-5' exonuclease activity
A6E01_06325	COG0419	ATPase involved in DNA repair
A6E01_06365	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6E01_06405	COG2814	Major facilitator Superfamily
A6E01_06430	COG1793	dna ligase
A6E01_06440	COG0307	riboflavin synthase, alpha
A6E01_06455	COG0791	NLP P60 protein
A6E01_06470	COG1940	carbohydrate kinase activity
A6E01_06495	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A6E01_06520	COG0589	response to stress
A6E01_06525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6E01_06535	COG2217	Heavy metal translocating P-type atpase
A6E01_06545	COG2010	Cytochrome c
A6E01_06560	COG3278	Belongs to the heme-copper respiratory oxidase family
A6E01_06570	COG2807	transmembrane transport
A6E01_06595	COG1067	ATP-dependent peptidase activity
A6E01_06600	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6E01_06615	COG0488	(ABC) transporter
A6E01_06625	COG0116	Belongs to the methyltransferase superfamily
A6E01_06625	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6E01_06635	COG0167	dihydroorotate dehydrogenase activity
A6E01_06665	COG1956	GAF domain-containing protein
A6E01_06670	COG2995	paraquat-inducible protein a
A6E01_06675	COG3008	intermembrane lipid transfer
A6E01_06690	COG0574	Belongs to the PEP-utilizing enzyme family
A6E01_06690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6E01_06695	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6E01_06710	COG3118	belongs to the thioredoxin family
A6E01_06720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6E01_06725	COG4597	amino acid ABC transporter
A6E01_06730	COG0765	amino acid transport
A6E01_06735	COG1126	abc transporter atp-binding protein
A6E01_06740	COG0670	Belongs to the BI1 family
A6E01_06745	COG2920	part of a sulfur-relay system
A6E01_06750	COG1254	Belongs to the acylphosphatase family
A6E01_06755	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6E01_06770	COG2885	chlorophyll binding
A6E01_06780	COG0561	phosphatase activity
A6E01_06800	COG1115	amino acid carrier protein
A6E01_06805	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A6E01_06810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6E01_06825	COG1280	lysine exporter protein (LysE YggA)
A6E01_06830	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A6E01_06835	COG0281	malic enzyme
A6E01_06845	COG3706	GGDEF domain
A6E01_06875	COG3302	dmso reductase anchor subunit
A6E01_06880	COG0437	4 iron, 4 sulfur cluster binding
A6E01_06885	COG0243	molybdopterin cofactor binding
A6E01_06890	COG3381	protein complex oligomerization
A6E01_06905	COG1643	Atp-dependent helicase
A6E01_06940	COG0443	Heat shock 70 kDa protein
A6E01_06945	COG0443	Heat shock 70 kDa protein
A6E01_06950	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6E01_06950	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6E01_06970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6E01_06975	COG3283	Transcriptional regulator of aromatic amino acids metabolism
A6E01_06980	COG3768	UPF0283 membrane protein
A6E01_06985	COG3106	COG3106 Predicted ATPase
A6E01_07000	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6E01_07005	COG0494	nUDIX hydrolase
A6E01_07010	COG0017	Asparaginyl-tRNA synthetase
A6E01_07015	COG1448	Aminotransferase
A6E01_07030	COG2176	DNA-directed DNA polymerase activity
A6E01_07045	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6E01_07060	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A6E01_07070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6E01_07075	COG2989	Protein conserved in bacteria
A6E01_07095	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6E01_07115	COG1058	Belongs to the CinA family
A6E01_07115	COG1546	Belongs to the CinA family
A6E01_07125	COG1960	acyl-CoA dehydrogenase activity
A6E01_07130	COG1309	transcriptional regulator
A6E01_07150	COG1136	(ABC) transporter
A6E01_07155	COG0702	epimerase
A6E01_07165	COG2814	Major facilitator Superfamily
A6E01_07170	COG1187	pseudouridine synthase activity
A6E01_07175	COG1061	Type III restriction enzyme res subunit
A6E01_07185	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A6E01_07190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6E01_07205	COG4172	Belongs to the ABC transporter superfamily
A6E01_07210	COG3313	Fe-S protein
A6E01_07230	COG2949	membrane
A6E01_07235	COG0492	ferredoxin-NADP+ reductase activity
A6E01_07240	COG4988	ABC transporter
A6E01_07245	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A6E01_07250	COG0604	alcohol dehydrogenase
A6E01_07260	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A6E01_07270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6E01_07270	COG4191	Histidine kinase
A6E01_07315	COG0415	Belongs to the DNA photolyase family
A6E01_07330	COG4166	transmembrane transport
A6E01_07345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6E01_07350	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
A6E01_07355	COG3070	regulator of competence-specific genes
A6E01_07360	COG2431	L-lysine efflux transmembrane transporter activity
A6E01_07370	COG0076	glutamate decarboxylase activity
A6E01_07375	COG1737	Transcriptional regulator
A6E01_07380	COG1454	alcohol dehydrogenase
A6E01_07385	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6E01_07390	COG3104	oligopeptide transport
A6E01_07415	COG2079	MmgE PrpD family protein
A6E01_07420	COG0372	Belongs to the citrate synthase family
A6E01_07425	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A6E01_07435	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6E01_07470	COG1757	Na H antiporter
A6E01_07475	COG4628	conserved protein (DUF2132)
A6E01_07480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6E01_07510	COG5413	integral membrane protein
A6E01_07520	COG1272	protein, Hemolysin III
A6E01_07535	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A6E01_07555	COG0747	negative chemotaxis
A6E01_07565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6E01_07565	COG1263	PTS System
A6E01_07570	COG0471	metal ion transport
A6E01_07590	COG2217	Heavy metal translocating P-type atpase
A6E01_07595	COG0789	Transcriptional regulator
A6E01_07615	COG4232	protein-disulfide reductase activity
A6E01_07620	COG3118	belongs to the thioredoxin family
A6E01_07625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6E01_07625	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6E01_07660	COG0702	epimerase
A6E01_07685	COG2153	protein acetylation
A6E01_07695	COG0513	Belongs to the DEAD box helicase family
A6E01_07710	COG0437	4 iron, 4 sulfur cluster binding
A6E01_07715	COG3383	formate dehydrogenase (NAD+) activity
A6E01_07745	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A6E01_07755	COG4662	Binding-protein-dependent transport system inner membrane component
A6E01_07765	COG0746	molybdenum cofactor guanylyltransferase activity
A6E01_07770	COG0303	'Molybdopterin
A6E01_07780	COG0346	lactoylglutathione lyase activity
A6E01_07785	COG1902	pentaerythritol trinitrate reductase activity
A6E01_07795	COG1024	Enoyl-CoA hydratase
A6E01_07805	COG0493	'glutamate synthase
A6E01_07810	COG0674	pyruvate-flavodoxin oxidoreductase activity
A6E01_07825	COG0564	pseudouridine synthase activity
A6E01_07830	COG0514	ATP-dependent DNA helicase (RecQ)
A6E01_07835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6E01_07845	COG0318	PFAM AMP-dependent synthetase and ligase
A6E01_07850	COG0786	glutamate:sodium symporter activity
A6E01_07880	COG1196	nuclear chromosome segregation
A6E01_07890	COG1401	restriction endodeoxyribonuclease activity
A6E01_07895	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
A6E01_07920	COG1360	Flagellar Motor Protein
A6E01_07950	COG5433	transposase activity
A6E01_08000	COG0582	viral genome integration into host DNA
A6E01_08015	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A6E01_08020	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
A6E01_08025	COG2885	chlorophyll binding
A6E01_08045	COG0811	peptide transport
A6E01_08050	COG0824	Thioesterase
A6E01_08060	COG4890	Cyd operon protein YbgT
A6E01_08065	COG1294	oxidase, subunit
A6E01_08070	COG1271	oxidase subunit
A6E01_08080	COG0632	four-way junction helicase activity
A6E01_08085	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A6E01_08095	COG4106	trans-aconitate 2-methyltransferase activity
A6E01_08105	COG0243	molybdopterin cofactor binding
A6E01_08110	COG3005	denitrification pathway
A6E01_08115	COG4459	periplasmic nitrate reductase
A6E01_08130	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A6E01_08135	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
A6E01_08145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6E01_08150	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A6E01_08185	COG2268	Band 7 protein
A6E01_08195	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6E01_08210	COG0300	oxidoreductase activity
A6E01_08225	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A6E01_08230	COG1073	alpha beta
A6E01_08230	COG2226	methyltransferase
A6E01_08245	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A6E01_08255	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6E01_08270	COG1522	sequence-specific DNA binding
A6E01_08275	COG0686	Belongs to the AlaDH PNT family
A6E01_08285	COG0583	DNA-binding transcription factor activity
A6E01_08300	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A6E01_08305	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
A6E01_08315	COG0539	negative regulation of cytoplasmic translation
A6E01_08330	COG0616	signal peptide processing
A6E01_08335	COG1028	Short-chain dehydrogenase reductase Sdr
A6E01_08345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6E01_08350	COG0778	Nitroreductase
A6E01_08355	COG1902	pentaerythritol trinitrate reductase activity
A6E01_08355	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6E01_08360	COG0616	signal peptide processing
A6E01_08365	COG0252	asparaginase activity
A6E01_08375	COG3139	Protein of unknown function (DUF1315)
A6E01_08380	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6E01_08390	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6E01_08395	COG0676	glucose-6-phosphate 1-epimerase activity
A6E01_08400	COG2226	methyltransferase
A6E01_08420	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6E01_08425	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6E01_08430	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A6E01_08445	COG2832	Protein of unknown function (DUF454)
A6E01_08450	COG0745	RESPONSE REGULATOR receiver
A6E01_08455	COG0583	DNA-binding transcription factor activity
A6E01_08460	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A6E01_08465	COG1286	toxin biosynthetic process
A6E01_08470	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
A6E01_08475	COG0285	dihydrofolate synthase activity
A6E01_08485	COG0101	tRNA pseudouridine synthase activity
A6E01_08495	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6E01_08500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6E01_08505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6E01_08510	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A6E01_08510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6E01_08525	COG3101	peptidyl-lysine hydroxylation
A6E01_08530	COG2860	membrane
A6E01_08540	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A6E01_08545	COG2890	protein-(glutamine-N5) methyltransferase activity
A6E01_08550	COG2840	Smr protein MutS2
A6E01_08555	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A6E01_08560	COG2062	phosphohistidine phosphatase, SixA
A6E01_08565	COG1025	Belongs to the peptidase M16 family
A6E01_08575	COG1024	Enoyl-CoA hydratase
A6E01_08575	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6E01_08580	COG0183	Belongs to the thiolase family
A6E01_08595	COG2067	long-chain fatty acid transport protein
A6E01_08605	COG2853	Lipoprotein
A6E01_08610	COG3088	subunit of a heme lyase
A6E01_08610	COG4235	cytochrome complex assembly
A6E01_08620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6E01_08625	COG1138	Cytochrome C-type biogenesis protein
A6E01_08640	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6E01_08645	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6E01_08650	COG4133	protoheme IX ABC transporter activity
A6E01_08665	COG0583	DNA-binding transcription factor activity
A6E01_08670	COG0737	Belongs to the 5'-nucleotidase family
A6E01_08680	COG1929	Belongs to the glycerate kinase type-1 family
A6E01_08685	COG0383	alpha-mannosidase activity
A6E01_08690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6E01_08690	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6E01_08690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6E01_08695	COG2188	Transcriptional regulator
A6E01_08705	COG1595	DNA-templated transcription, initiation
A6E01_08715	COG2095	MarC family integral membrane protein
A6E01_08720	COG1902	pentaerythritol trinitrate reductase activity
A6E01_08730	COG3069	C4-dicarboxylate transmembrane transporter activity
A6E01_08735	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6E01_08745	COG1794	racemase activity, acting on amino acids and derivatives
A6E01_08750	COG2982	Protein involved in outer membrane biogenesis
A6E01_08755	COG0572	uridine kinase
A6E01_08760	COG0489	protein tyrosine kinase activity
A6E01_08765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6E01_08765	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6E01_08775	COG1940	carbohydrate kinase activity
A6E01_08780	COG4667	esterase of the alpha-beta hydrolase superfamily
A6E01_08790	COG0733	neurotransmitter:sodium symporter activity
A6E01_08800	COG1263	PTS System
A6E01_08800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6E01_08805	COG0084	hydrolase, TatD family'
A6E01_08810	COG0470	DNA polymerase III
A6E01_08815	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A6E01_08820	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6E01_08850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6E01_08855	COG0416	fatty acid biosynthetic process
A6E01_08865	COG1399	metal-binding, possibly nucleic acid-binding protein
A6E01_08870	COG0424	maF-like protein
A6E01_08875	COG0564	pseudouridine synthase activity
A6E01_08880	COG1530	ribonuclease E activity
A6E01_08885	COG0659	secondary active sulfate transmembrane transporter activity
A6E01_08920	COG0667	Aldo Keto reductase
A6E01_08935	COG3135	benzoate transporter
A6E01_08940	COG1396	sequence-specific DNA binding
A6E01_08945	COG0697	spore germination
A6E01_08965	COG0679	Auxin Efflux Carrier
A6E01_08975	COG1461	Dihydroxyacetone kinase
A6E01_08980	COG2376	Dihydroxyacetone kinase
A6E01_09000	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A6E01_09005	COG0698	ribose 5-phosphate isomerase
A6E01_09010	COG1494	fructose-1,6-bisphosphatase
A6E01_09025	COG1472	Belongs to the glycosyl hydrolase 3 family
A6E01_09055	COG2951	lytic endotransglycosylase activity
A6E01_09060	COG3100	YcgL domain-containing protein
A6E01_09065	COG0850	regulation of cytokinetic process
A6E01_09070	COG2894	cell division
A6E01_09075	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A6E01_09080	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A6E01_09085	COG0318	PFAM AMP-dependent synthetase and ligase
A6E01_09100	COG1214	PFAM Peptidase M22, glycoprotease
A6E01_09105	COG1199	ATP-dependent helicase activity
A6E01_09110	COG0788	formyltetrahydrofolate deformylase activity
A6E01_09115	COG3102	Protein conserved in bacteria
A6E01_09125	COG1227	inorganic diphosphatase activity
A6E01_09140	COG0534	Mate efflux family protein
A6E01_09145	COG0583	DNA-binding transcription factor activity
A6E01_09150	COG0733	neurotransmitter:sodium symporter activity
A6E01_09175	COG1918	ferrous iron import across plasma membrane
A6E01_09180	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A6E01_09185	COG1121	(ABC) transporter
A6E01_09190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6E01_09200	COG0045	succinate-CoA ligase (ADP-forming) activity
A6E01_09205	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6E01_09210	COG0567	Dehydrogenase, E1 component
A6E01_09220	COG1053	succinate dehydrogenase
A6E01_09225	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A6E01_09230	COG2009	succinate dehydrogenase
A6E01_09235	COG0372	Belongs to the citrate synthase family
A6E01_09240	COG4580	involved in the transport of maltose and maltodextrins
A6E01_09270	COG1609	Transcriptional regulator
A6E01_09275	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A6E01_09285	COG0033	Phosphoglucomutase
A6E01_09295	COG0596	Alpha beta hydrolase
A6E01_09310	COG0735	belongs to the Fur family
A6E01_09320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6E01_09325	COG2190	(PTS) system
A6E01_09325	COG1263	PTS System
A6E01_09325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6E01_09335	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A6E01_09340	COG1940	carbohydrate kinase activity
A6E01_09340	COG1846	Transcriptional regulator
A6E01_09345	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A6E01_09345	COG4651	solute:proton antiporter activity
A6E01_09350	COG2203	Gaf domain
A6E01_09350	COG3706	GGDEF domain
A6E01_09350	COG5001	Diguanylate cyclase
A6E01_09350	COG4251	negative regulation of phosphorylation
A6E01_09355	COG0367	asparagine synthase
A6E01_09365	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A6E01_09375	COG0326	Molecular chaperone. Has ATPase activity
A6E01_09380	COG3710	Transcriptional regulator
A6E01_09390	COG0622	Phosphoesterase
A6E01_09415	COG1090	epimerase
A6E01_09420	COG3118	belongs to the thioredoxin family
A6E01_09425	COG0330	HflC and HflK could
A6E01_09450	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A6E01_09455	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6E01_09465	COG2190	(PTS) system
A6E01_09470	COG2837	iron assimilation
A6E01_09490	COG1393	Belongs to the ArsC family
A6E01_09495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6E01_09515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6E01_09520	COG2716	regulation of RNA biosynthetic process
A6E01_09525	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6E01_09535	COG4783	chaperone-mediated protein folding
A6E01_09540	COG1393	Belongs to the ArsC family
A6E01_09550	COG3507	Belongs to the glycosyl hydrolase 43 family
A6E01_09560	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A6E01_09565	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A6E01_09570	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6E01_09580	COG3335	DDE superfamily endonuclease
A6E01_09585	COG0121	glutamine amidotransferase
A6E01_09590	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A6E01_09595	COG1960	acyl-CoA dehydrogenase activity
A6E01_09600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6E01_09605	COG0328	RNA-DNA hybrid ribonuclease activity
A6E01_09610	COG2226	methyltransferase
A6E01_09615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6E01_09620	COG1388	LysM domain
A6E01_09620	COG0741	lytic transglycosylase activity
A6E01_09625	COG3021	interspecies interaction between organisms
A6E01_09630	COG0347	Belongs to the P(II) protein family
A6E01_09650	COG0587	DNA-directed DNA polymerase activity
A6E01_09665	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6E01_09670	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6E01_09675	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6E01_09680	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
A6E01_09685	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6E01_09690	COG0750	zinc metalloprotease
A6E01_09700	COG0575	Belongs to the CDS family
A6E01_09705	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6E01_09730	COG0024	Methionine aminopeptidase
A6E01_09735	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A6E01_09750	COG0564	pseudouridine synthase activity
A6E01_09755	COG3098	single-species biofilm formation
A6E01_09785	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A6E01_09795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6E01_09800	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
A6E01_09810	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6E01_09810	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6E01_09820	COG1611	Belongs to the LOG family
A6E01_09825	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6E01_09835	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
A6E01_09840	COG0583	DNA-binding transcription factor activity
A6E01_09845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6E01_09845	COG0301	tRNA thio-modification
A6E01_09855	COG0142	geranyltranstransferase activity
A6E01_09860	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A6E01_09865	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A6E01_09870	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A6E01_09895	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6E01_09895	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6E01_09905	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A6E01_09910	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6E01_09925	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A6E01_09930	COG2252	PERMEase
A6E01_09935	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6E01_09945	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6E01_09945	COG0047	phosphoribosylformylglycinamidine synthase activity
A6E01_09950	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A6E01_09955	COG0590	tRNA wobble adenosine to inosine editing
A6E01_09975	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A6E01_10000	COG0484	heat shock protein binding
A6E01_10005	COG0443	Heat shock 70 kDa protein
A6E01_10010	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A6E01_10015	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A6E01_10020	COG0497	DNA recombination
A6E01_10025	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6E01_10030	COG2914	Belongs to the UPF0125 (RnfH) family
A6E01_10035	COG2867	negative regulation of translational initiation
A6E01_10040	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A6E01_10060	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6E01_10075	COG1028	Short-chain dehydrogenase reductase Sdr
A6E01_10080	COG1917	Cupin 2, conserved barrel domain protein
A6E01_10085	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6E01_10090	COG1904	glucuronate isomerase
A6E01_10105	COG0765	amino acid transport
A6E01_10115	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A6E01_10120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6E01_10125	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A6E01_10135	COG4221	oxidoreductase activity
A6E01_10140	COG0583	DNA-binding transcription factor activity
A6E01_10145	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6E01_10150	COG0110	maltose O-acetyltransferase activity
A6E01_10175	COG3181	Tripartite tricarboxylate transporter family receptor
A6E01_10185	COG0798	PFAM Bile acid sodium symporter
A6E01_10195	COG0583	DNA-binding transcription factor activity
A6E01_10200	COG2116	formate transmembrane transporter activity
A6E01_10205	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6E01_10210	COG4136	ATPase activity
A6E01_10215	COG4135	transport system, permease component
A6E01_10220	COG4134	Bacterial extracellular solute-binding protein
A6E01_10225	COG3122	Protein conserved in bacteria
A6E01_10235	COG0516	GMP reductase activity
A6E01_10235	COG0517	IMP dehydrogenase activity
A6E01_10250	COG1160	GTP binding
A6E01_10255	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6E01_10260	COG2976	Protein conserved in bacteria
A6E01_10285	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A6E01_10295	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6E01_10300	COG2975	iron-sulfur cluster assembly
A6E01_10305	COG0633	Ferredoxin
A6E01_10320	COG0316	Belongs to the HesB IscA family
A6E01_10325	COG0822	iron-sulfur transferase activity
A6E01_10345	COG0483	inositol monophosphate 1-phosphatase activity
A6E01_10350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6E01_10355	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6E01_10360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6E01_10370	COG1534	Rna-binding protein
A6E01_10375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6E01_10380	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A6E01_10385	COG2027	D-alanyl-D-alanine carboxypeptidase
A6E01_10390	COG2239	Acts as a magnesium transporter
A6E01_10395	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6E01_10400	COG0739	heme binding
A6E01_10410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6E01_10415	COG1566	PFAM secretion protein HlyD family protein
A6E01_10430	COG0628	permease
A6E01_10435	COG2813	Specifically methylates the guanine in position
A6E01_10440	COG2205	protein histidine kinase activity
A6E01_10440	COG0784	Response regulator, receiver
A6E01_10445	COG0747	negative chemotaxis
A6E01_10460	COG0444	Belongs to the ABC transporter superfamily
A6E01_10465	COG4608	Belongs to the ABC transporter superfamily
A6E01_10480	COG3842	ATPase activity
A6E01_10490	COG1840	ABC-type Fe3 transport system, periplasmic component
A6E01_10495	COG0004	ammonium transporteR
A6E01_10510	COG3835	regulator
A6E01_10515	COG2610	gluconate transmembrane transporter activity
A6E01_10520	COG1929	Belongs to the glycerate kinase type-1 family
A6E01_10525	COG1049	propionate catabolic process, 2-methylcitrate cycle
A6E01_10530	COG1752	Esterase of the alpha-beta hydrolase superfamily
A6E01_10535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6E01_10540	COG1643	Atp-dependent helicase
A6E01_10550	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6E01_10555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6E01_10565	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6E01_10570	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A6E01_10575	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A6E01_10580	COG0842	Transport permease protein
A6E01_10585	COG1131	(ABC) transporter
A6E01_10590	COG0288	reversible hydration of carbon dioxide
A6E01_10600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6E01_10605	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6E01_10610	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A6E01_10615	COG2186	Transcriptional regulator
A6E01_10625	COG0157	Belongs to the NadC ModD family
A6E01_10635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6E01_10640	COG1459	type II secretion system
A6E01_10650	COG0237	dephospho-CoA kinase activity
A6E01_10655	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
A6E01_10660	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A6E01_10685	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6E01_10690	COG4137	Cytochrome C assembly protein
A6E01_10695	COG4536	flavin adenine dinucleotide binding
A6E01_10700	COG1854	S-ribosylhomocysteine lyase activity
A6E01_10710	COG0612	Peptidase, M16
A6E01_10715	COG1238	metal cluster binding
A6E01_10720	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A6E01_10725	COG5016	pyruvate
A6E01_10725	COG0511	ligase activity, forming carbon-carbon bonds
A6E01_10780	COG0527	aspartate kinase activity
A6E01_10790	COG2137	regulation of response to DNA damage stimulus
A6E01_10795	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6E01_10805	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A6E01_10810	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6E01_10815	COG4942	peptidase
A6E01_10815	COG1388	LysM domain
A6E01_10825	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A6E01_10835	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A6E01_10850	COG0148	phosphopyruvate hydratase activity
A6E01_10860	COG3956	TIGRFAM MazG family protein
A6E01_10865	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6E01_10870	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6E01_10880	COG0736	holo-[acyl-carrier-protein] synthase activity
A6E01_10885	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A6E01_10890	COG1381	Involved in DNA repair and RecF pathway recombination
A6E01_10905	COG0681	Belongs to the peptidase S26 family
A6E01_10910	COG0481	GTPase activity
A6E01_10920	COG3026	antisigma factor binding
A6E01_10935	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A6E01_10940	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A6E01_10960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6E01_10965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6E01_10985	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6E01_10990	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A6E01_10995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6E01_11005	COG0668	transmembrane transport
A6E01_11010	COG0191	fructose-bisphosphate aldolase activity
A6E01_11020	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6E01_11025	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A6E01_11045	COG2356	endonuclease I
A6E01_11050	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6E01_11055	COG0189	ligase activity
A6E01_11065	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6E01_11080	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6E01_11085	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6E01_11090	COG0762	integral membrane protein
A6E01_11100	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A6E01_11105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6E01_11110	COG2066	Belongs to the glutaminase family
A6E01_11125	COG1194	a g-specific adenine glycosylase
A6E01_11200	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6E01_11200	COG2213	PTS system mannitol-specific
A6E01_11205	COG0246	Mannitol dehydrogenase
A6E01_11210	COG3722	fumarate hydratase activity
A6E01_11220	COG1349	DNA-binding transcription factor activity
A6E01_11225	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6E01_11230	COG1609	Transcriptional regulator
A6E01_11230	COG2207	Transcriptional regulator
A6E01_11235	COG2115	Belongs to the xylose isomerase family
A6E01_11255	COG0395	ABC-type sugar transport system, permease component
A6E01_11260	COG1175	transmembrane transport
A6E01_11270	COG3842	ATPase activity
A6E01_11275	COG3842	ATPase activity
A6E01_11280	COG2115	Belongs to the xylose isomerase family
A6E01_11285	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A6E01_11290	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A6E01_11295	COG1070	Carbohydrate kinase
A6E01_11310	COG0795	lipopolysaccharide-transporting ATPase activity
A6E01_11315	COG0795	lipopolysaccharide-transporting ATPase activity
A6E01_11325	COG2927	DNA polymerase III (CHI subunit)
A6E01_11330	COG0525	valine-tRNA ligase activity
A6E01_11365	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
A6E01_11375	COG0204	Acyl-transferase
A6E01_11385	COG5007	Belongs to the BolA IbaG family
A6E01_11395	COG2854	intermembrane phospholipid transfer
A6E01_11400	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6E01_11405	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6E01_11410	COG1127	ABC transporter
A6E01_11420	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A6E01_11420	COG0517	IMP dehydrogenase activity
A6E01_11425	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A6E01_11440	COG1137	ATPase activity
A6E01_11455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6E01_11465	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6E01_11470	COG2239	Acts as a magnesium transporter
A6E01_11475	COG0312	modulator of DNA gyrase
A6E01_11485	COG0312	modulator of DNA gyrase
A6E01_11490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6E01_11495	COG3164	Protein of unknown function
A6E01_11500	COG1530	ribonuclease E activity
A6E01_11510	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A6E01_11515	COG1792	Involved in formation and maintenance of cell shape
A6E01_11520	COG1077	Cell shape determining protein MreB Mrl
A6E01_11555	COG4969	Belongs to the N-Me-Phe pilin family
A6E01_11570	COG1459	type II secretion system
A6E01_11585	COG3409	Peptidoglycan-binding domain 1 protein
A6E01_11585	COG3267	Type II secretory pathway component ExeA
A6E01_11590	COG1450	Type ii and iii secretion system protein
A6E01_11610	COG2200	EAL domain
A6E01_11610	COG2199	diguanylate cyclase activity
A6E01_11630	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6E01_11640	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A6E01_11645	COG0527	aspartate kinase activity
A6E01_11650	COG1410	methionine synthase
A6E01_11650	COG0646	methionine synthase
A6E01_11675	COG3335	DDE superfamily endonuclease
A6E01_11755	COG0175	sulfate reduction
A6E01_11760	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6E01_11765	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A6E01_11785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6E01_11795	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6E01_11800	COG0305	Participates in initiation and elongation during chromosome replication
A6E01_11830	COG0778	Nitroreductase
A6E01_11840	COG0557	exoribonuclease II activity
A6E01_11845	COG1959	2 iron, 2 sulfur cluster binding
A6E01_11850	COG1017	nitric oxide dioxygenase activity
A6E01_11850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6E01_11855	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A6E01_11860	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
A6E01_11865	COG0330	HflC and HflK could
A6E01_11870	COG0330	HflC and HflK could
A6E01_11875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6E01_11885	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6E01_11890	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A6E01_11895	COG0860	N-Acetylmuramoyl-L-alanine amidase
A6E01_11900	COG0802	atpase or kinase
A6E01_11905	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6E01_11960	COG1162	GTPase activity
A6E01_11965	COG0688	phosphatidylethanolamine metabolic process
A6E01_11975	COG1575	Belongs to the MenA family. Type 1 subfamily
A6E01_11980	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A6E01_11985	COG0471	metal ion transport
A6E01_11985	COG3273	potassium ion transport
A6E01_12000	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A6E01_12005	COG1053	succinate dehydrogenase
A6E01_12010	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A6E01_12020	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
A6E01_12025	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6E01_12030	COG1509	lysine 2,3-aminomutase activity
A6E01_12040	COG0488	(ABC) transporter
A6E01_12045	COG1119	ATPase activity
A6E01_12055	COG0459	protein refolding
A6E01_12060	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A6E01_12075	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A6E01_12080	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A6E01_12085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6E01_12095	COG4942	peptidase
A6E01_12105	COG1494	fructose-1,6-bisphosphatase
A6E01_12120	COG0149	triose-phosphate isomerase activity
A6E01_12125	COG0205	6-phosphofructokinase activity
A6E01_12140	COG0745	RESPONSE REGULATOR receiver
A6E01_12145	COG2205	protein histidine kinase activity
A6E01_12150	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A6E01_12155	COG3030	protein affecting phage T7 exclusion by the F plasmid
A6E01_12160	COG1943	Transposase
A6E01_12165	COG1027	Aspartate ammonia-lyase
A6E01_12170	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A6E01_12175	COG4232	protein-disulfide reductase activity
A6E01_12190	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6E01_12200	COG2205	protein histidine kinase activity
A6E01_12200	COG2198	Histidine kinase
A6E01_12200	COG0784	Response regulator, receiver
A6E01_12205	COG2814	Major facilitator Superfamily
A6E01_12220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6E01_12230	COG0511	ligase activity, forming carbon-carbon bonds
A6E01_12235	COG0439	Biotin carboxylase
A6E01_12240	COG2264	protein methyltransferase activity
A6E01_12250	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
A6E01_12265	COG0789	Transcriptional regulator
A6E01_12275	COG0151	Belongs to the GarS family
A6E01_12285	COG2207	Transcriptional regulator
A6E01_12300	COG1253	flavin adenine dinucleotide binding
A6E01_12305	COG3068	Protein conserved in bacteria
A6E01_12325	COG1561	YicC-like family, N-terminal region
A6E01_12345	COG1758	RNA polymerase activity
A6E01_12350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6E01_12355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6E01_12360	COG2003	Belongs to the UPF0758 family
A6E01_12365	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6E01_12370	COG0756	dUTP diphosphatase activity
A6E01_12375	COG1309	transcriptional regulator
A6E01_12380	COG1560	Kdo2-lipid A biosynthetic process
A6E01_12385	COG1560	Kdo2-lipid A biosynthetic process
A6E01_12390	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A6E01_12400	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
A6E01_12405	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6E01_12410	COG0085	RNA polymerase activity
A6E01_12425	COG0081	regulation of translation
A6E01_12430	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6E01_12435	COG0250	Participates in transcription elongation, termination and antitermination
A6E01_12440	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6E01_12445	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6E01_12470	COG1072	(Pantothenic acid kinase))
A6E01_12475	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A6E01_12475	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A6E01_12490	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6E01_12500	COG3335	DDE superfamily endonuclease
A6E01_12560	COG0724	RNA recognition motif
A6E01_12590	COG0534	Mate efflux family protein
A6E01_12600	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A6E01_12610	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A6E01_12620	COG0705	Rhomboid family
A6E01_12625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6E01_12635	COG2177	Part of the ABC transporter FtsEX involved in
A6E01_12640	COG2884	Cell division ATP-binding protein ftsE
A6E01_12645	COG0552	protein localization to endoplasmic reticulum
A6E01_12650	COG0742	ribosomal rna small subunit methyltransferase
A6E01_12690	COG0210	DNA helicase
A6E01_12695	COG1309	transcriptional regulator
A6E01_12700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6E01_12705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6E01_12720	COG0583	DNA-binding transcription factor activity
A6E01_12745	COG3335	DDE superfamily endonuclease
A6E01_12785	COG2871	sodium ion transport
A6E01_12790	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A6E01_12800	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A6E01_12805	COG3118	belongs to the thioredoxin family
A6E01_12810	COG0513	Belongs to the DEAD box helicase family
A6E01_12815	COG0248	Ppx GppA phosphatase
A6E01_12820	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6E01_12825	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A6E01_12835	COG0514	ATP-dependent DNA helicase (RecQ)
A6E01_12840	COG2962	Rard protein
A6E01_12845	COG1280	lysine exporter protein (LysE YggA)
A6E01_12850	COG0405	Gamma-glutamyltransferase
A6E01_12855	COG2095	MarC family integral membrane protein
A6E01_12860	COG0210	DNA helicase
A6E01_12870	COG3220	belongs to the UPF0276 family
A6E01_12910	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6E01_12915	COG0352	thiamine-phosphate diphosphorylase activity
A6E01_12965	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6E01_12970	COG1739	Uncharacterized protein family UPF0029
A6E01_12980	COG0183	Belongs to the thiolase family
A6E01_12985	COG0604	alcohol dehydrogenase
A6E01_12990	COG0583	DNA-binding transcription factor activity
A6E01_13000	COG2119	membrane
A6E01_13015	COG3977	Valine--pyruvate aminotransferase
A6E01_13035	COG0071	Belongs to the small heat shock protein (HSP20) family
A6E01_13040	COG0187	DNA topoisomerase II activity
A6E01_13050	COG0592	DNA-directed DNA polymerase activity
A6E01_13075	COG1444	tRNA N-acetyltransferase activity
A6E01_13085	COG2274	protein secretion by the type I secretion system
A6E01_13100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6E01_13115	COG4206	TonB-dependent receptor
A6E01_13130	COG4667	esterase of the alpha-beta hydrolase superfamily
A6E01_13135	COG0390	transport system, permease component
A6E01_13140	COG0668	transmembrane transport
A6E01_13165	COG3386	PFAM SMP-30 Gluconolaconase
A6E01_13170	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A6E01_13175	COG2203	Gaf domain
A6E01_13175	COG3706	GGDEF domain
A6E01_13175	COG4251	negative regulation of phosphorylation
A6E01_13175	COG5001	Diguanylate cyclase
A6E01_13180	COG2814	Major facilitator Superfamily
A6E01_13185	COG0583	DNA-binding transcription factor activity
A6E01_13195	COG1309	transcriptional regulator
A6E01_13200	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6E01_13210	COG3724	N-succinylarginine dihydrolase activity
A6E01_13220	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A6E01_13220	COG0519	Catalyzes the synthesis of GMP from XMP
A6E01_13225	COG1132	(ABC) transporter
A6E01_13240	COG4580	involved in the transport of maltose and maltodextrins
A6E01_13250	COG1523	belongs to the glycosyl hydrolase 13 family
A6E01_13275	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6E01_13300	COG2169	Transcriptional regulator
A6E01_13300	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6E01_13320	COG0668	transmembrane transport
A6E01_13325	COG1565	acr, cog1565
A6E01_13325	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A6E01_13330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A6E01_13335	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
A6E01_13360	COG1612	heme a metabolic process
A6E01_13365	COG0109	protoheme IX farnesyltransferase activity
A6E01_13375	COG1785	Belongs to the alkaline phosphatase family
A6E01_13380	COG1028	Short-chain dehydrogenase reductase Sdr
A6E01_13390	COG2130	NADP-dependent
A6E01_13395	COG1454	alcohol dehydrogenase
A6E01_13415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6E01_13425	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6E01_13430	COG0753	catalase activity
A6E01_13440	COG1024	Enoyl-CoA hydratase
A6E01_13450	COG0583	DNA-binding transcription factor activity
A6E01_13460	COG0069	glutamate synthase activity
A6E01_13465	COG0646	methionine synthase
A6E01_13465	COG1410	methionine synthase
A6E01_13490	COG1418	mRNA catabolic process
A6E01_13505	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6E01_13510	COG0583	DNA-binding transcription factor activity
A6E01_13570	COG1595	DNA-templated transcription, initiation
A6E01_13605	COG3842	ATPase activity
A6E01_13615	COG3665	Urea carboxylase-associated protein
A6E01_13640	COG2304	oxidoreductase activity
A6E01_13655	COG0714	Associated with various cellular activities
A6E01_13665	COG1757	Na H antiporter
A6E01_13670	COG0174	glutamine synthetase
A6E01_13675	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A6E01_13680	COG1396	sequence-specific DNA binding
A6E01_13680	COG1917	Cupin 2, conserved barrel domain protein
A6E01_13685	COG1012	belongs to the aldehyde dehydrogenase family
A6E01_13690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6E01_13700	COG2957	Belongs to the agmatine deiminase family
A6E01_13705	COG1012	belongs to the aldehyde dehydrogenase family
A6E01_13710	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A6E01_13735	COG4989	oxidoreductase activity
A6E01_13755	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A6E01_13760	COG0402	S-adenosylhomocysteine deaminase activity
A6E01_13790	COG2814	Major facilitator Superfamily
A6E01_13805	COG3278	Belongs to the heme-copper respiratory oxidase family
A6E01_13815	COG0243	molybdopterin cofactor binding
A6E01_13825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6E01_13835	COG2223	nitrite transmembrane transporter activity
A6E01_13840	COG2815	serine threonine protein kinase
A6E01_13840	COG0515	serine threonine protein kinase
A6E01_13865	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6E01_13880	COG1115	amino acid carrier protein
A6E01_13905	COG2433	Pfam Transposase IS66
A6E01_13920	COG5433	transposase activity
A6E01_13970	COG0509	glycine decarboxylation via glycine cleavage system
A6E01_13990	COG0179	Fumarylacetoacetate (FAA) hydrolase
A6E01_14000	COG0583	DNA-binding transcription factor activity
A6E01_14025	COG1278	Cold shock
A6E01_14035	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6E01_14045	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A6E01_14055	COG0583	DNA-binding transcription factor activity
A6E01_14060	COG0443	Heat shock 70 kDa protein
A6E01_14070	COG0811	peptide transport
A6E01_14075	COG0811	peptide transport
A6E01_14080	COG0848	biopolymer transport protein
A6E01_14105	COG2801	Transposase and inactivated derivatives
A6E01_14120	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A6E01_14125	COG1177	transmembrane transport
A6E01_14130	COG1176	ABC-type spermidine putrescine transport system, permease component I
A6E01_14140	COG0583	DNA-binding transcription factor activity
A6E01_14170	COG2433	Pfam Transposase IS66
A6E01_14185	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A6E01_14200	COG2963	transposase activity
A6E01_14205	COG2801	Transposase and inactivated derivatives
A6E01_14210	COG2252	PERMEase
A6E01_14230	COG0366	Alpha amylase catalytic
A6E01_14245	COG4989	oxidoreductase activity
A6E01_14255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6E01_14265	COG0277	FAD linked oxidase domain protein
A6E01_14270	COG1304	FMN binding
A6E01_14275	COG1620	l-lactate permease
A6E01_14280	COG0583	DNA-binding transcription factor activity
A6E01_14285	COG0583	DNA-binding transcription factor activity
A6E01_14295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6E01_14315	COG3344	reverse transcriptase
A6E01_14340	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A6E01_14345	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A6E01_14350	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A6E01_14385	COG0784	Response regulator, receiver
A6E01_14385	COG2205	protein histidine kinase activity
A6E01_14395	COG0300	oxidoreductase activity
A6E01_14400	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A6E01_14405	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
A6E01_14410	COG1289	transmembrane transporter activity
A6E01_14415	COG0210	DNA helicase
A6E01_14435	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A6E01_14480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6E01_14490	COG0848	biopolymer transport protein
A6E01_14495	COG0811	peptide transport
A6E01_14500	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
A6E01_14510	COG3721	Heme iron utilization protein
A6E01_14515	COG0748	coenzyme F420 binding
A6E01_14525	COG1132	(ABC) transporter
A6E01_14550	COG2801	Transposase and inactivated derivatives
A6E01_14560	COG3005	denitrification pathway
A6E01_14570	COG0243	molybdopterin cofactor binding
A6E01_14575	COG3062	negative regulation of establishment of protein localization
A6E01_14580	COG3850	Histidine kinase
A6E01_14585	COG2197	response regulator
A6E01_14590	COG3360	Dodecin
A6E01_14595	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A6E01_14620	COG0523	cobalamin synthesis protein
A6E01_14630	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A6E01_14635	COG5433	transposase activity
A6E01_14640	COG4221	oxidoreductase activity
A6E01_14645	COG1917	Cupin 2, conserved barrel domain protein
A6E01_14645	COG4977	sequence-specific DNA binding
A6E01_14655	COG0513	Belongs to the DEAD box helicase family
A6E01_14675	COG1584	GPR1 FUN34 yaaH family protein
A6E01_14680	COG0531	amino acid
A6E01_14700	COG0437	4 iron, 4 sulfur cluster binding
A6E01_14705	COG3301	Polysulphide reductase, NrfD
A6E01_14710	COG1138	Cytochrome C-type biogenesis protein
A6E01_14715	COG4235	cytochrome complex assembly
A6E01_14715	COG3088	subunit of a heme lyase
A6E01_14725	COG0346	lactoylglutathione lyase activity
A6E01_14730	COG3119	arylsulfatase activity
A6E01_14735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6E01_14740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6E01_14745	COG3119	arylsulfatase activity
A6E01_14755	COG0714	Associated with various cellular activities
A6E01_14785	COG0583	DNA-binding transcription factor activity
A6E01_14810	COG0641	radical SAM
A6E01_14825	COG2814	Major facilitator Superfamily
A6E01_14830	COG4221	oxidoreductase activity
A6E01_14840	COG0583	DNA-binding transcription factor activity
A6E01_14870	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A6E01_14870	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A6E01_14875	COG0405	Gamma-glutamyltransferase
A6E01_14895	COG1573	uracil-dna glycosylase
A6E01_14915	COG4565	transcriptional regulatory protein
A6E01_14920	COG3290	protein histidine kinase activity
A6E01_14925	COG0765	amino acid transport
A6E01_14935	COG0765	amino acid transport
A6E01_14940	COG1126	abc transporter atp-binding protein
A6E01_14945	COG0583	DNA-binding transcription factor activity
A6E01_14955	COG0729	surface antigen
A6E01_14960	COG3214	Protein conserved in bacteria
A6E01_14975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6E01_14980	COG2272	Belongs to the type-B carboxylesterase lipase family
A6E01_14995	COG0004	ammonium transporteR
A6E01_15005	COG0800	Aldolase
A6E01_15010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6E01_15015	COG1917	Cupin 2, conserved barrel domain protein
A6E01_15040	COG2186	Transcriptional regulator
A6E01_15045	COG2186	Transcriptional regulator
A6E01_15050	COG0517	IMP dehydrogenase activity
A6E01_15055	COG2176	DNA-directed DNA polymerase activity
A6E01_15110	COG3394	polysaccharide catabolic process
A6E01_15115	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6E01_15125	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6E01_15155	COG1051	belongs to the nudix hydrolase family
A6E01_15195	COG3437	response regulator, receiver
A6E01_15230	COG0656	L-ascorbic acid biosynthetic process
A6E01_15245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6E01_15250	COG1309	transcriptional regulator
A6E01_15305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6E01_15320	COG0351	phosphomethylpyrimidine kinase
A6E01_15325	COG1116	anion transmembrane transporter activity
A6E01_15330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6E01_15335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A6E01_15340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A6E01_15345	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A6E01_15350	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A6E01_15370	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A6E01_15395	COG0625	glutathione transferase activity
A6E01_15400	COG2501	S4 domain
A6E01_15405	COG1979	alcohol dehydrogenase
A6E01_15420	COG0513	Belongs to the DEAD box helicase family
A6E01_15425	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A6E01_15430	COG0653	protein targeting
A6E01_15445	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A6E01_15455	COG0583	DNA-binding transcription factor activity
A6E01_15460	COG1280	lysine exporter protein (LysE YggA)
A6E01_15465	COG1403	HNH endonuclease
A6E01_15470	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6E01_15495	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6E01_15500	COG2146	nitrite reductase [NAD(P)H] activity
A6E01_15505	COG2116	formate transmembrane transporter activity
A6E01_15510	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6E01_15510	COG1648	precorrin-2 dehydrogenase activity
A6E01_15530	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6E01_15535	COG1215	transferase activity, transferring glycosyl groups
A6E01_15540	COG0438	transferase activity, transferring glycosyl groups
A6E01_15580	COG0714	Associated with various cellular activities
A6E01_15610	COG5433	transposase activity
A6E01_15620	COG1309	transcriptional regulator
A6E01_15660	COG2814	Major facilitator Superfamily
A6E01_15695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6E01_15695	COG1263	PTS System
A6E01_15700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6E01_15705	COG1621	beta-fructofuranosidase activity
A6E01_15725	COG0583	DNA-binding transcription factor activity
A6E01_15755	COG3344	reverse transcriptase
A6E01_15770	COG0642	Histidine kinase
A6E01_15775	COG0745	RESPONSE REGULATOR receiver
A6E01_15785	COG1028	Short-chain dehydrogenase reductase Sdr
A6E01_15810	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A6E01_15815	COG1396	sequence-specific DNA binding
A6E01_15835	COG1028	Short-chain dehydrogenase reductase Sdr
A6E01_15840	COG2866	Carboxypeptidase
A6E01_15850	COG0346	lactoylglutathione lyase activity
A6E01_15875	COG0110	maltose O-acetyltransferase activity
A6E01_15930	COG2204	response regulator
A6E01_15960	COG0784	Response regulator, receiver
A6E01_15960	COG2205	protein histidine kinase activity
A6E01_15975	COG2801	Transposase and inactivated derivatives
A6E01_15990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6E01_15995	COG0545	Peptidyl-prolyl cis-trans isomerase
A6E01_16005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6E01_16020	COG0546	phosphoglycolate phosphatase activity
A6E01_16030	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A6E01_16045	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6E01_16055	COG1472	Belongs to the glycosyl hydrolase 3 family
A6E01_16065	COG0640	Transcriptional regulator
A6E01_16085	COG1328	CTP reductase activity
A6E01_16090	COG0602	queuosine metabolic process
A6E01_16100	COG4067	protein conserved in archaea
A6E01_16100	COG0189	ligase activity
A6E01_16105	COG0725	ABC transporter, periplasmic molybdate-binding protein
A6E01_16110	COG4149	molybdate abc transporter
A6E01_16115	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A6E01_16135	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A6E01_16140	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A6E01_16175	COG1741	Belongs to the pirin family
A6E01_16180	COG0583	DNA-binding transcription factor activity
A6E01_16185	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A6E01_16190	COG2252	PERMEase
A6E01_16195	COG0023	Translation Initiation Factor
A6E01_16215	COG1042	CoA-binding domain protein
A6E01_16215	COG0045	succinate-CoA ligase (ADP-forming) activity
A6E01_16215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6E01_16220	COG0583	DNA-binding transcription factor activity
A6E01_16230	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A6E01_16235	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A6E01_16245	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
A6E01_16250	COG4181	ATPase activity
A6E01_16260	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6E01_16265	COG5001	Diguanylate cyclase
A6E01_16265	COG3300	MHYT domain
A6E01_16285	COG0714	Associated with various cellular activities
A6E01_16290	COG0494	nUDIX hydrolase
A6E01_16305	COG0513	Belongs to the DEAD box helicase family
A6E01_16320	COG0534	Mate efflux family protein
A6E01_16335	COG0671	phosphoesterase, PA-phosphatase related
A6E01_16340	COG0123	including yeast histone deacetylase and acetoin utilization protein
A6E01_16345	COG0513	Belongs to the DEAD box helicase family
A6E01_16355	COG4166	transmembrane transport
A6E01_16360	COG4174	ABC transporter (Permease)
A6E01_16365	COG4239	(ABC) transporter, permease
A6E01_16375	COG4172	Belongs to the ABC transporter superfamily
A6E01_16380	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A6E01_16395	COG1566	PFAM secretion protein HlyD family protein
A6E01_16410	COG4533	DNA binding
A6E01_16420	COG2050	protein possibly involved in aromatic compounds catabolism
A6E01_16430	COG2824	Alkylphosphonate utilization operon protein PhnA
A6E01_16435	COG3263	regulation of cellular component size
A6E01_16445	COG0330	HflC and HflK could
A6E01_16460	COG1597	lipid kinase activity
A6E01_16475	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6E01_16475	COG1902	pentaerythritol trinitrate reductase activity
A6E01_16490	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A6E01_16495	COG0814	amino acid
A6E01_16500	COG1760	l-serine dehydratase
A6E01_16520	COG0737	Belongs to the 5'-nucleotidase family
A6E01_16525	COG3593	DNA synthesis involved in DNA repair
A6E01_16540	COG3038	cytochrome b561
A6E01_16560	COG0786	glutamate:sodium symporter activity
A6E01_16565	COG0488	(ABC) transporter
A6E01_16575	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A6E01_16580	COG0363	glucosamine-6-phosphate deaminase activity
A6E01_16585	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A6E01_16595	COG0625	glutathione transferase activity
A6E01_16600	COG3530	Putative quorum-sensing-regulated virulence factor
A6E01_16625	COG3813	Protein conserved in bacteria
A6E01_16635	COG1063	alcohol dehydrogenase
A6E01_16640	COG0156	8-amino-7-oxononanoate synthase activity
A6E01_16650	COG2723	6-phospho-beta-galactosidase activity
A6E01_16670	COG0393	Putative heavy-metal-binding
A6E01_16675	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A6E01_16690	COG1765	OsmC-like protein
A6E01_16695	COG1278	Cold shock
A6E01_16700	COG4681	YaeQ
A6E01_16710	COG0628	permease
A6E01_16715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6E01_16745	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A6E01_16765	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A6E01_16770	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6E01_16780	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A6E01_16795	COG1067	ATP-dependent peptidase activity
A6E01_16820	COG3250	beta-galactosidase activity
A6E01_16840	COG0583	DNA-binding transcription factor activity
A6E01_16850	COG0583	DNA-binding transcription factor activity
A6E01_16855	COG1609	Transcriptional regulator
A6E01_16860	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6E01_16860	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6E01_16865	COG1105	Belongs to the carbohydrate kinase PfkB family
A6E01_16870	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A6E01_16870	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6E01_16870	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6E01_16900	COG0513	Belongs to the DEAD box helicase family
A6E01_16910	COG1136	(ABC) transporter
A6E01_16910	COG0577	efflux transmembrane transporter activity
A6E01_16915	COG1136	(ABC) transporter
A6E01_16915	COG0577	efflux transmembrane transporter activity
A6E01_16930	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A6E01_16945	COG0739	heme binding
A6E01_16980	COG3842	ATPase activity
A6E01_17015	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6E01_17020	COG0581	inorganic phosphate transmembrane transporter activity
A6E01_17025	COG0573	inorganic phosphate transmembrane transporter activity
A6E01_17030	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A6E01_17045	COG1376	ErfK ybiS ycfS ynhG family protein
A6E01_17045	COG1388	LysM domain
A6E01_17050	COG0415	Belongs to the DNA photolyase family
A6E01_17055	COG3272	Protein of unknown function (DUF1722)
A6E01_17075	COG1566	PFAM secretion protein HlyD family protein
A6E01_17090	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6E01_17095	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A6E01_17100	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6E01_17125	COG1162	GTPase activity
A6E01_17130	COG0366	Alpha amylase catalytic
A6E01_17145	COG0602	queuosine metabolic process
A6E01_17150	COG0720	synthase
A6E01_17160	COG2264	protein methyltransferase activity
A6E01_17205	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A6E01_17210	COG1640	4-alpha-glucanotransferase
A6E01_17215	COG0058	SHG alpha-glucan phosphorylase activity
A6E01_17220	COG2909	trisaccharide binding
A6E01_17235	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6E01_17240	COG1216	Glycosyl transferase, family 2
A6E01_17245	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A6E01_17245	COG0519	Catalyzes the synthesis of GMP from XMP
A6E01_17250	COG1216	Glycosyl transferase, family 2
A6E01_17280	COG2801	Transposase and inactivated derivatives
A6E01_17285	COG3550	peptidyl-serine autophosphorylation
A6E01_17290	COG1943	Transposase
A6E01_17305	COG1396	sequence-specific DNA binding
A6E01_17325	COG4942	peptidase
A6E01_17345	COG3335	DDE superfamily endonuclease
A6E01_17455	COG0729	surface antigen
A6E01_17470	COG4251	negative regulation of phosphorylation
A6E01_17470	COG2203	Gaf domain
A6E01_17470	COG5001	Diguanylate cyclase
A6E01_17470	COG3706	GGDEF domain
A6E01_17480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6E01_17490	COG2895	sulfate adenylyltransferase (ATP) activity
A6E01_17500	COG0529	Catalyzes the synthesis of activated sulfate
A6E01_17510	COG0175	sulfate reduction
A6E01_17515	COG3273	potassium ion transport
A6E01_17515	COG0471	metal ion transport
A6E01_17535	COG0438	transferase activity, transferring glycosyl groups
A6E01_17560	COG1215	transferase activity, transferring glycosyl groups
A6E01_17570	COG3206	protein involved in exopolysaccharide biosynthesis
A6E01_17570	COG0489	protein tyrosine kinase activity
A6E01_17585	COG1596	polysaccharide export
A6E01_17590	COG0175	sulfate reduction
A6E01_17600	COG2895	sulfate adenylyltransferase (ATP) activity
A6E01_17605	COG3273	potassium ion transport
A6E01_17605	COG0471	metal ion transport
A6E01_17610	COG0529	Catalyzes the synthesis of activated sulfate
A6E01_17680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6E01_17685	COG1132	(ABC) transporter
A6E01_17700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6E01_17715	COG3842	ATPase activity
A6E01_17730	COG2814	Major facilitator Superfamily
A6E01_17740	COG1840	ABC-type Fe3 transport system, periplasmic component
A6E01_17790	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A6E01_17810	COG1737	Transcriptional regulator
A6E01_17815	COG1126	abc transporter atp-binding protein
A6E01_17820	COG0765	amino acid transport
A6E01_17825	COG0765	amino acid transport
A6E01_17840	COG2816	NAD+ diphosphatase activity
A6E01_17845	COG1760	l-serine dehydratase
A6E01_17850	COG0010	Belongs to the arginase family
A6E01_17855	COG1166	arginine decarboxylase activity
A6E01_17860	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A6E01_17880	COG2211	Major facilitator Superfamily
A6E01_17895	COG2015	COG2015, Alkyl sulfatase and related hydrolases
A6E01_17905	COG0519	Catalyzes the synthesis of GMP from XMP
A6E01_17905	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A6E01_17925	COG1012	belongs to the aldehyde dehydrogenase family
A6E01_17940	COG1177	transmembrane transport
A6E01_17945	COG1176	ABC-type spermidine putrescine transport system, permease component I
A6E01_17950	COG3842	ATPase activity
A6E01_17955	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A6E01_17965	COG0174	glutamine synthetase
A6E01_17970	COG0174	glutamine synthetase
A6E01_17975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6E01_17985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6E01_17990	COG4213	ABC transporter substrate-binding protein
A6E01_17995	COG1129	ABC transporter
A6E01_18000	COG4214	carbohydrate transport
A6E01_18005	COG3710	Transcriptional regulator
A6E01_18020	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6E01_18025	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6E01_18075	COG0583	DNA-binding transcription factor activity
A6E01_18080	COG3459	Glycosyltransferase 36 associated
A6E01_18085	COG2211	Major facilitator Superfamily
A6E01_18090	COG2207	Transcriptional regulator
A6E01_18105	COG1028	Short-chain dehydrogenase reductase Sdr
A6E01_18110	COG5433	transposase activity
A6E01_18115	COG1741	Belongs to the pirin family
A6E01_18120	COG2259	Doxx family
A6E01_18125	COG0583	DNA-binding transcription factor activity
A6E01_18135	COG0435	Glutathione S-transferase
A6E01_18150	COG4221	oxidoreductase activity
A6E01_18155	COG5433	transposase activity
A6E01_18160	COG1522	sequence-specific DNA binding
A6E01_18165	COG1280	lysine exporter protein (LysE YggA)
A6E01_18170	COG1609	Transcriptional regulator
A6E01_18190	COG0583	DNA-binding transcription factor activity
A6E01_18225	COG2738	Putative neutral zinc metallopeptidase
A6E01_18235	COG2026	Addiction module toxin, RelE StbE family
A6E01_18245	COG0513	Belongs to the DEAD box helicase family
A6E01_18250	COG1846	Transcriptional regulator
A6E01_18255	COG1764	response to oxidative stress
A6E01_18260	COG1028	Short-chain dehydrogenase reductase Sdr
A6E01_18260	COG0604	alcohol dehydrogenase
A6E01_18260	COG3321	synthase
A6E01_18265	COG2190	(PTS) system
A6E01_18265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6E01_18265	COG1263	PTS System
A6E01_18270	COG0583	DNA-binding transcription factor activity
A6E01_18275	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
A6E01_18280	COG2944	sequence-specific DNA binding
A6E01_18305	COG0564	pseudouridine synthase activity
A6E01_18355	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6E01_18365	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6E01_18400	COG1438	arginine binding
A6E01_18405	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6E01_18410	COG1823	symporter activity
A6E01_18420	COG2964	Protein conserved in bacteria
A6E01_18460	COG0189	ligase activity
A6E01_18460	COG4067	protein conserved in archaea
A6E01_18475	COG1335	isochorismatase
A6E01_18480	COG0252	asparaginase activity
A6E01_18520	COG0583	DNA-binding transcription factor activity
A6E01_18525	COG0589	response to stress
A6E01_18535	COG2985	domain, Protein
A6E01_18545	COG0786	glutamate:sodium symporter activity
A6E01_18565	COG2824	Alkylphosphonate utilization operon protein PhnA
A6E01_18595	COG0583	DNA-binding transcription factor activity
A6E01_18600	COG1869	D-ribose catabolic process
A6E01_18605	COG1129	ABC transporter
A6E01_18610	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6E01_18615	COG1879	ABC-type sugar transport system periplasmic component
A6E01_18620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6E01_18625	COG1609	Transcriptional regulator
A6E01_18630	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6E01_18635	COG0569	domain protein
A6E01_18640	COG2176	DNA-directed DNA polymerase activity
A6E01_18690	COG4608	Belongs to the ABC transporter superfamily
A6E01_18695	COG0444	Belongs to the ABC transporter superfamily
A6E01_18700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6E01_18705	COG0601	transmembrane transport
A6E01_18725	COG1609	Transcriptional regulator
A6E01_18730	COG0437	4 iron, 4 sulfur cluster binding
A6E01_18735	COG0348	domain, Protein
A6E01_18745	COG1136	(ABC) transporter
A6E01_18775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6E01_18815	COG0739	heme binding
A6E01_18825	COG2084	Dehydrogenase
A6E01_18845	COG3174	membrane
A6E01_18895	COG1987	bacterial-type flagellum assembly
A6E01_18900	COG1338	Plays a role in the flagellum-specific transport system
A6E01_18900	COG3190	flagellar
A6E01_18915	COG1815	bacterial-type flagellum-dependent cell motility
A6E01_18920	COG1558	bacterial-type flagellum-dependent cell motility
A6E01_18930	COG1749	Flagellar hook protein flgE
A6E01_18935	COG4787	bacterial-type flagellum-dependent cell motility
A6E01_18945	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A6E01_18950	COG1706	bacterial-type flagellum-dependent cell motility
A6E01_18965	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6E01_18975	COG1677	Flagellar hook-basal body complex protein FliE
A6E01_18980	COG1766	The M ring may be actively involved in energy transduction
A6E01_19055	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6E01_19060	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A6E01_19090	COG1191	sigma factor activity
A6E01_19095	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A6E01_19170	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6E01_19205	COG0628	permease
A6E01_19260	COG2885	chlorophyll binding
A6E01_19260	COG3047	cAMP biosynthetic process
A6E01_19455	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6E01_19455	COG0678	peroxiredoxin activity
A6E01_19525	COG3550	peptidyl-serine autophosphorylation
A6E01_19555	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A6E01_19570	COG0105	UTP biosynthetic process
A6E01_19580	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6E01_19600	COG2003	Belongs to the UPF0758 family
A6E01_19640	COG0194	GDP metabolic process
A6E01_19725	COG2974	May be involved in recombination
A6E01_19735	COG0425	Belongs to the sulfur carrier protein TusA family
A6E01_19825	COG1475	DNA binding
A6E01_19910	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A6E01_20035	COG2433	Pfam Transposase IS66
A6E01_20185	COG0531	amino acid
A6E01_20190	COG2957	Belongs to the agmatine deiminase family
A6E01_20265	COG0330	HflC and HflK could
A6E01_20380	COG3081	Nucleoid-associated protein
A6E01_20420	COG0739	heme binding
A6E01_20625	COG2925	Exonuclease
A6E01_20645	COG0668	transmembrane transport
A6E01_20705	COG0629	single-stranded DNA binding
A6E01_20725	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A6E01_20795	COG1875	ATPase related to phosphate starvation-inducible protein PhoH