locus-tag	class	description
M892_00010	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M892_00035	COG3335	DDE superfamily endonuclease
M892_00050	COG3335	DDE superfamily endonuclease
M892_00060	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
M892_00065	COG0626	cystathionine gamma-synthase activity
M892_00075	COG0733	neurotransmitter:sodium symporter activity
M892_00085	COG0564	pseudouridine synthase activity
M892_00095	COG3335	DDE superfamily endonuclease
M892_00100	COG1151	hydroxylamine reductase activity
M892_00105	COG3604	Transcriptional regulator
M892_00120	COG2814	Major facilitator Superfamily
M892_00130	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M892_00135	COG4136	ATPase activity
M892_00140	COG4135	transport system, permease component
M892_00145	COG4134	Bacterial extracellular solute-binding protein
M892_00150	COG0398	Pfam SNARE associated Golgi protein
M892_00175	COG0659	secondary active sulfate transmembrane transporter activity
M892_00185	COG3313	Fe-S protein
M892_00225	COG2205	protein histidine kinase activity
M892_00230	COG0745	RESPONSE REGULATOR receiver
M892_00240	COG1061	Type III restriction enzyme res subunit
M892_00245	COG1187	pseudouridine synthase activity
M892_00250	COG2814	Major facilitator Superfamily
M892_00260	COG3344	reverse transcriptase
M892_00265	COG0702	epimerase
M892_00270	COG0534	Mate efflux family protein
M892_00275	COG4181	ATPase activity
M892_00300	COG2433	Pfam Transposase IS66
M892_00325	COG1960	acyl-CoA dehydrogenase activity
M892_00330	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M892_00340	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M892_00345	COG1737	Transcriptional regulator
M892_00350	COG0076	glutamate decarboxylase activity
M892_00360	COG2431	L-lysine efflux transmembrane transporter activity
M892_00370	COG3070	regulator of competence-specific genes
M892_00385	COG4191	Histidine kinase
M892_00385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M892_00395	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M892_00405	COG5001	Diguanylate cyclase
M892_00430	COG3293	Transposase
M892_00440	COG2200	EAL domain
M892_00445	COG3293	Transposase
M892_00455	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M892_00460	COG4988	ABC transporter
M892_00465	COG0492	ferredoxin-NADP+ reductase activity
M892_00470	COG3335	DDE superfamily endonuclease
M892_00480	COG3547	Transposase (IS116 IS110 IS902 family)
M892_00495	COG3547	Transposase (IS116 IS110 IS902 family)
M892_00500	COG3547	Transposase (IS116 IS110 IS902 family)
M892_00525	COG3547	Transposase (IS116 IS110 IS902 family)
M892_00560	COG3344	reverse transcriptase
M892_00625	COG3340	Belongs to the peptidase S51 family
M892_00645	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M892_00670	COG1609	Transcriptional regulator
M892_00695	COG0596	Alpha beta hydrolase
M892_00710	COG3335	DDE superfamily endonuclease
M892_00745	COG1328	CTP reductase activity
M892_00750	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M892_00765	COG0861	Integral membrane protein TerC family
M892_00775	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M892_00780	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M892_00785	COG4221	oxidoreductase activity
M892_00790	COG1454	alcohol dehydrogenase
M892_00795	COG0814	amino acid
M892_00815	COG1132	(ABC) transporter
M892_00820	COG1132	(ABC) transporter
M892_00840	COG0443	Heat shock 70 kDa protein
M892_00845	COG0443	Heat shock 70 kDa protein
M892_00855	COG3706	GGDEF domain
M892_00890	COG3227	Zinc metalloprotease (Elastase)
M892_00900	COG0243	molybdopterin cofactor binding
M892_00905	COG0437	4 iron, 4 sulfur cluster binding
M892_00910	COG3302	dmso reductase anchor subunit
M892_00925	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M892_00930	COG1643	Atp-dependent helicase
M892_00955	COG3293	Transposase
M892_00965	COG3063	Type IV pilus biogenesis stability protein PilW
M892_00975	COG3385	transposase activity
M892_00985	COG3344	reverse transcriptase
M892_01010	COG0531	amino acid
M892_01015	COG1280	lysine exporter protein (LysE YggA)
M892_01020	COG1560	Kdo2-lipid A biosynthetic process
M892_01045	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M892_01050	COG1280	lysine exporter protein (LysE YggA)
M892_01085	COG1115	amino acid carrier protein
M892_01110	COG1368	sulfuric ester hydrolase activity
M892_01115	COG3335	DDE superfamily endonuclease
M892_01130	COG0215	cysteine-tRNA ligase activity
M892_01140	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
M892_01150	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M892_01155	COG0456	acetyltransferase
M892_01160	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M892_01170	COG0527	aspartate kinase activity
M892_01180	COG1858	cytochrome C peroxidase
M892_01185	COG1404	Belongs to the peptidase S8 family
M892_01220	COG2433	Pfam Transposase IS66
M892_01250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M892_01270	COG3290	protein histidine kinase activity
M892_01275	COG4565	transcriptional regulatory protein
M892_01280	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M892_01285	COG0363	glucosamine-6-phosphate deaminase activity
M892_01290	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M892_01295	COG3344	reverse transcriptase
M892_01310	COG3284	Transcriptional regulator
M892_01315	COG1012	belongs to the aldehyde dehydrogenase family
M892_01325	COG0840	transmembrane signaling receptor activity
M892_01330	COG0730	response to heat
M892_01365	COG2433	Pfam Transposase IS66
M892_01385	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M892_01410	COG2433	Pfam Transposase IS66
M892_01415	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M892_01420	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M892_01430	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M892_01435	COG0372	Belongs to the citrate synthase family
M892_01445	COG2828	Protein conserved in bacteria
M892_01460	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M892_01465	COG3397	chitin binding
M892_01485	COG0561	phosphatase activity
M892_01490	COG0602	queuosine metabolic process
M892_01500	COG3706	GGDEF domain
M892_01520	COG2433	Pfam Transposase IS66
M892_01565	COG1254	Belongs to the acylphosphatase family
M892_01570	COG2920	part of a sulfur-relay system
M892_01575	COG0670	Belongs to the BI1 family
M892_01580	COG1126	abc transporter atp-binding protein
M892_01590	COG4597	amino acid ABC transporter
M892_01595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M892_01610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M892_01635	COG3008	intermembrane lipid transfer
M892_01640	COG2995	paraquat-inducible protein a
M892_01650	COG1956	GAF domain-containing protein
M892_01655	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
M892_01670	COG0308	aminopeptidase N
M892_01680	COG2902	Dehydrogenase
M892_01835	COG0784	Response regulator, receiver
M892_01835	COG2205	protein histidine kinase activity
M892_01850	COG3278	Belongs to the heme-copper respiratory oxidase family
M892_01865	COG2010	Cytochrome c
M892_01885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M892_01890	COG0589	response to stress
M892_01920	COG1176	ABC-type spermidine putrescine transport system, permease component I
M892_01925	COG1177	transmembrane transport
M892_01930	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M892_01940	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M892_01970	COG0437	4 iron, 4 sulfur cluster binding
M892_01975	COG0243	molybdopterin cofactor binding
M892_01975	COG3383	formate dehydrogenase (NAD+) activity
M892_01985	COG3381	protein complex oligomerization
M892_02005	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M892_02015	COG0488	(ABC) transporter
M892_02030	COG4191	Histidine kinase
M892_02035	COG2204	response regulator
M892_02045	COG4662	Binding-protein-dependent transport system inner membrane component
M892_02050	COG3842	ATPase activity
M892_02060	COG0303	'Molybdopterin
M892_02075	COG1940	carbohydrate kinase activity
M892_02115	COG3344	reverse transcriptase
M892_02130	COG0840	transmembrane signaling receptor activity
M892_02135	COG0791	NLP P60 protein
M892_02145	COG3706	GGDEF domain
M892_02150	COG2201	protein-glutamate methylesterase activity
M892_02165	COG0307	riboflavin synthase, alpha
M892_02170	COG0534	Mate efflux family protein
M892_02190	COG2885	chlorophyll binding
M892_02210	COG2204	response regulator
M892_02215	COG0438	transferase activity, transferring glycosyl groups
M892_02220	COG0438	transferase activity, transferring glycosyl groups
M892_02250	COG0438	transferase activity, transferring glycosyl groups
M892_02255	COG1215	transferase activity, transferring glycosyl groups
M892_02260	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M892_02285	COG5001	Diguanylate cyclase
M892_02285	COG3300	MHYT domain
M892_02290	COG3437	response regulator, receiver
M892_02290	COG3850	Histidine kinase
M892_02290	COG4999	Histidine kinase
M892_02290	COG2205	protein histidine kinase activity
M892_02310	COG0110	maltose O-acetyltransferase activity
M892_02340	COG1846	Transcriptional regulator
M892_02355	COG3247	response to pH
M892_02360	COG0668	transmembrane transport
M892_02375	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
M892_02395	COG0668	transmembrane transport
M892_02420	COG0657	acetylesterase activity
M892_02440	COG0625	glutathione transferase activity
M892_02450	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
M892_02465	COG3335	DDE superfamily endonuclease
M892_02470	COG2195	Cleaves the N-terminal amino acid of tripeptides
M892_02480	COG3335	DDE superfamily endonuclease
M892_02540	COG3335	DDE superfamily endonuclease
M892_02585	COG1451	nucleotide metabolic process
M892_02595	COG2433	Pfam Transposase IS66
M892_02610	COG0583	DNA-binding transcription factor activity
M892_02635	COG3335	DDE superfamily endonuclease
M892_02645	COG4139	cobalamin transport
M892_02665	COG2062	phosphohistidine phosphatase, SixA
M892_02675	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
M892_02685	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M892_02690	COG0702	epimerase
M892_02705	COG2925	Exonuclease
M892_02715	COG1346	cytolysis
M892_02755	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M892_02760	COG4605	iron ion homeostasis
M892_02765	COG4607	ABC-type enterochelin transport system periplasmic component
M892_02770	COG4774	siderophore transport
M892_02775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M892_02785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M892_02805	COG1535	isochorismatase
M892_02805	COG3433	isochorismatase activity
M892_02820	COG2433	Pfam Transposase IS66
M892_02830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M892_02830	COG0072	phenylalanine-tRNA ligase activity
M892_02850	COG0251	oxidation-reduction process
M892_02870	COG2433	Pfam Transposase IS66
M892_02915	COG0010	Belongs to the arginase family
M892_02925	COG2986	histidine ammonia-lyase
M892_02970	COG0247	lactate metabolic process
M892_02970	COG0277	FAD linked oxidase domain protein
M892_03100	COG1643	Atp-dependent helicase
M892_03110	COG2949	membrane
M892_03115	COG0471	metal ion transport
M892_03120	COG0745	RESPONSE REGULATOR receiver
M892_03120	COG3706	GGDEF domain
M892_03135	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M892_03150	COG3335	DDE superfamily endonuclease
M892_03165	COG2433	Pfam Transposase IS66
M892_03185	COG3344	reverse transcriptase
M892_03330	COG1030	water channel activity
M892_03360	COG3772	lysozyme
M892_03415	COG1403	HNH endonuclease
M892_03435	COG4626	Terminase
M892_03435	COG1802	Transcriptional regulator
M892_03460	COG3620	sequence-specific DNA binding
M892_03480	COG5532	Uncharacterized conserved protein (DUF2303)
M892_03500	COG0582	viral genome integration into host DNA
M892_03545	COG2433	Pfam Transposase IS66
M892_03570	COG2433	Pfam Transposase IS66
M892_03615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M892_03630	COG3106	COG3106 Predicted ATPase
M892_03645	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M892_03660	COG0814	amino acid
M892_03665	COG1760	l-serine dehydratase
M892_03670	COG3385	transposase activity
M892_03690	COG2197	response regulator
M892_03695	COG0720	synthase
M892_03710	COG0017	Asparaginyl-tRNA synthetase
M892_03725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M892_03740	COG1448	Aminotransferase
M892_03765	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M892_03770	COG1846	Transcriptional regulator
M892_03780	COG3335	DDE superfamily endonuclease
M892_03790	COG2818	Glycosylase
M892_03810	COG1983	PspC domain protein
M892_03820	COG1842	Phage shock protein A
M892_03825	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M892_03835	COG4168	peptide transport system, permease
M892_03840	COG4171	peptide transport system, permease
M892_03850	COG4172	Belongs to the ABC transporter superfamily
M892_03880	COG1227	inorganic diphosphatase activity
M892_03895	COG0243	molybdopterin cofactor binding
M892_03905	COG4459	periplasmic nitrate reductase
M892_03910	COG0390	transport system, permease component
M892_03920	COG2116	formate transmembrane transporter activity
M892_03945	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M892_03950	COG3344	reverse transcriptase
M892_03965	COG1435	thymidine kinase activity
M892_03970	COG0215	cysteine-tRNA ligase activity
M892_03975	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M892_03980	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M892_03985	COG3012	SEC-C Motif Domain Protein
M892_03990	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M892_03990	COG0140	phosphoribosyl-ATP diphosphatase activity
M892_04005	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M892_04010	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M892_04010	COG0131	Imidazoleglycerol-phosphate dehydratase
M892_04020	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M892_04030	COG1757	Na H antiporter
M892_04040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M892_04060	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M892_04080	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M892_04095	COG0300	oxidoreductase activity
M892_04115	COG3344	reverse transcriptase
M892_04125	COG2226	methyltransferase
M892_04145	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M892_04165	COG3335	DDE superfamily endonuclease
M892_04175	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M892_04185	COG1674	ftsk spoiiie
M892_04195	COG0686	Belongs to the AlaDH PNT family
M892_04220	COG3547	Transposase (IS116 IS110 IS902 family)
M892_04235	COG0402	S-adenosylhomocysteine deaminase activity
M892_04255	COG2433	Pfam Transposase IS66
M892_04280	COG3568	Endonuclease Exonuclease Phosphatase
M892_04310	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
M892_04325	COG3293	Transposase
M892_04340	COG1120	ATPase activity
M892_04345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M892_04350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M892_04370	COG1288	antiporter activity
M892_04380	COG2186	Transcriptional regulator
M892_04390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M892_04395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M892_04415	COG2824	Alkylphosphonate utilization operon protein PhnA
M892_04435	COG3385	transposase activity
M892_04465	COG0457	Tetratricopeptide repeat
M892_04530	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M892_04535	COG4790	Type iii secretion
M892_04540	COG4794	Type iii secretion
M892_04545	COG4791	protein targeting
M892_04550	COG4792	protein secretion
M892_04555	COG0583	DNA-binding transcription factor activity
M892_04570	COG3335	DDE superfamily endonuclease
M892_04580	COG3335	DDE superfamily endonuclease
M892_04585	COG3335	DDE superfamily endonuclease
M892_04590	COG3177	Filamentation induced by cAMP protein fic
M892_04620	COG4669	(LipO)protein
M892_04720	COG3385	transposase activity
M892_04790	COG5433	transposase activity
M892_04830	COG3335	DDE superfamily endonuclease
M892_04845	COG2433	Pfam Transposase IS66
M892_04900	COG2433	Pfam Transposase IS66
M892_04905	COG3335	DDE superfamily endonuclease
M892_04955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M892_04960	COG4689	acetoacetate decarboxylase
M892_04965	COG3426	butyrate kinase activity
M892_04970	COG0280	phosphate acetyltransferase
M892_05000	COG2433	Pfam Transposase IS66
M892_05015	COG0582	viral genome integration into host DNA
M892_05030	COG2205	protein histidine kinase activity
M892_05030	COG0784	Response regulator, receiver
M892_05040	COG0754	glutathionylspermidine amidase activity
M892_05050	COG3766	membrane
M892_05065	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
M892_05070	COG2885	chlorophyll binding
M892_05075	COG0823	Involved in the tonB-independent uptake of proteins
M892_05090	COG0811	peptide transport
M892_05095	COG0824	Thioesterase
M892_05105	COG4890	Cyd operon protein YbgT
M892_05110	COG1294	oxidase, subunit
M892_05115	COG1271	oxidase subunit
M892_05125	COG0632	four-way junction helicase activity
M892_05130	COG0840	transmembrane signaling receptor activity
M892_05145	COG1801	Protein of unknown function DUF72
M892_05160	COG0189	ligase activity
M892_05160	COG4067	protein conserved in archaea
M892_05180	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
M892_05185	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
M892_05195	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M892_05200	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M892_05205	COG3385	transposase activity
M892_05210	COG0745	RESPONSE REGULATOR receiver
M892_05225	COG3070	regulator of competence-specific genes
M892_05245	COG0297	glycogen (starch) synthase activity
M892_05250	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M892_05255	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M892_05290	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M892_05295	COG0542	response to heat
M892_05305	COG1278	Cold shock
M892_05315	COG1187	pseudouridine synthase activity
M892_05320	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M892_05330	COG1199	ATP-dependent helicase activity
M892_05335	COG0730	response to heat
M892_05340	COG3923	Primosomal replication protein n
M892_05350	COG0708	Exodeoxyribonuclease III
M892_05360	COG4215	(ABC) transporter
M892_05385	COG1882	Formate acetyltransferase
M892_05395	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M892_05410	COG2766	serine protein kinase
M892_05415	COG2718	Belongs to the UPF0229 family
M892_05420	COG2719	SpoVR family
M892_05440	COG1132	(ABC) transporter
M892_05445	COG0658	competence protein
M892_05445	COG2333	competence protein COMEC
M892_05455	COG4591	ABC-type transport system involved in lipoprotein release permease component
M892_05460	COG1136	(ABC) transporter
M892_05465	COG4591	ABC-type transport system involved in lipoprotein release permease component
M892_05475	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M892_05490	COG1252	NADH dehydrogenase
M892_05520	COG0537	adenosine 5'-monophosphoramidase activity
M892_05540	COG2217	Heavy metal translocating P-type atpase
M892_05550	COG0516	GMP reductase activity
M892_05550	COG0517	IMP dehydrogenase activity
M892_05555	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
M892_05560	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M892_05565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M892_05660	COG2433	Pfam Transposase IS66
M892_05670	COG4372	Transposase
M892_05730	COG2433	Pfam Transposase IS66
M892_05755	COG2433	Pfam Transposase IS66
M892_05785	COG3706	GGDEF domain
M892_05800	COG3126	Type III secretion system lipoprotein chaperone (YscW)
M892_05805	COG1946	Acyl-CoA thioesterase
M892_05810	COG1522	sequence-specific DNA binding
M892_05830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M892_05835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M892_05865	COG2855	membrane
M892_05885	COG1441	menaquinone biosynthetic process
M892_05890	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M892_05895	COG0596	Alpha beta hydrolase
M892_05905	COG1169	isochorismate synthase
M892_05910	COG0436	Aminotransferase
M892_05915	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
M892_05935	COG1555	photosystem II stabilization
M892_05940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M892_05945	COG0776	regulation of translation
M892_05950	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M892_05980	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M892_05985	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M892_06005	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M892_06010	COG0569	domain protein
M892_06015	COG0513	Belongs to the DEAD box helicase family
M892_06025	COG4771	TonB-dependent receptor
M892_06030	COG2977	Belongs to the P-Pant transferase superfamily
M892_06040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M892_06040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M892_06045	COG3433	isochorismatase activity
M892_06045	COG1535	isochorismatase
M892_06050	COG1021	2,3-dihydroxybenzoate-AMP ligase
M892_06055	COG1169	isochorismate synthase
M892_06065	COG1028	Short-chain dehydrogenase reductase Sdr
M892_06095	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M892_06105	COG2951	lytic endotransglycosylase activity
M892_06120	COG2894	cell division
M892_06125	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M892_06135	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
M892_06140	COG0318	PFAM AMP-dependent synthetase and ligase
M892_06145	COG2267	carboxylic ester hydrolase activity
M892_06150	COG3065	identical protein binding
M892_06160	COG1214	PFAM Peptidase M22, glycoprotease
M892_06165	COG1199	ATP-dependent helicase activity
M892_06170	COG0788	formyltetrahydrofolate deformylase activity
M892_06180	COG3102	Protein conserved in bacteria
M892_06210	COG1918	ferrous iron import across plasma membrane
M892_06215	COG4977	sequence-specific DNA binding
M892_06220	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
M892_06225	COG1121	(ABC) transporter
M892_06230	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M892_06245	COG0508	dehydrogenase complex catalyzes the overall conversion of
M892_06250	COG0567	Dehydrogenase, E1 component
M892_06260	COG1053	succinate dehydrogenase
M892_06265	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M892_06270	COG2009	succinate dehydrogenase
M892_06280	COG3547	Transposase (IS116 IS110 IS902 family)
M892_06285	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M892_06295	COG0033	Phosphoglucomutase
M892_06305	COG0596	Alpha beta hydrolase
M892_06325	COG0735	belongs to the Fur family
M892_06330	COG2165	general secretion pathway protein
M892_06340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M892_06340	COG1263	PTS System
M892_06340	COG2190	(PTS) system
M892_06345	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M892_06350	COG1846	Transcriptional regulator
M892_06350	COG1940	carbohydrate kinase activity
M892_06355	COG4651	solute:proton antiporter activity
M892_06355	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M892_06360	COG0367	asparagine synthase
M892_06370	COG3104	oligopeptide transport
M892_06375	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M892_06390	COG3710	Transcriptional regulator
M892_06410	COG0622	Phosphoesterase
M892_06420	COG1090	epimerase
M892_06425	COG0300	oxidoreductase activity
M892_06430	COG3118	belongs to the thioredoxin family
M892_06435	COG0330	HflC and HflK could
M892_06480	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
M892_06485	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M892_06490	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M892_06495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M892_06500	COG2190	(PTS) system
M892_06505	COG3344	reverse transcriptase
M892_06510	COG3335	DDE superfamily endonuclease
M892_06520	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M892_06525	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M892_06530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M892_06545	COG3344	reverse transcriptase
M892_06550	COG3951	Flagellar rod assembly protein muramidase FlgJ
M892_06550	COG1705	Flagellar rod assembly protein muramidase FlgJ
M892_06555	COG1706	bacterial-type flagellum-dependent cell motility
M892_06560	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M892_06565	COG4786	Flagellar basal body rod
M892_06570	COG4787	bacterial-type flagellum-dependent cell motility
M892_06575	COG1749	Flagellar hook protein flgE
M892_06580	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M892_06585	COG1558	bacterial-type flagellum-dependent cell motility
M892_06590	COG1815	bacterial-type flagellum-dependent cell motility
M892_06595	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M892_06600	COG0835	chemotaxis
M892_06600	COG0784	Response regulator, receiver
M892_06660	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M892_06670	COG2608	mercury ion transmembrane transporter activity
M892_06670	COG2217	Heavy metal translocating P-type atpase
M892_06720	COG2840	Smr protein MutS2
M892_06725	COG1187	pseudouridine synthase activity
M892_06730	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M892_06735	COG0737	Belongs to the 5'-nucleotidase family
M892_06745	COG2912	Transglutaminase-like superfamily
M892_06750	COG3094	Invasion gene expression up-regulator, SirB
M892_06755	COG2890	protein-(glutamine-N5) methyltransferase activity
M892_06780	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M892_06790	COG0012	GTP binding
M892_06815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M892_06825	COG1702	phosphate starvation-inducible protein PhoH
M892_06835	COG4535	Mg2 and Co2 transporter CorC
M892_06840	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M892_06850	COG2888	peptidyl-tyrosine sulfation
M892_06860	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
M892_06865	COG1466	dna polymerase III delta subunit
M892_06870	COG0799	negative regulation of ribosome biogenesis
M892_06880	COG0768	penicillin binding
M892_06885	COG0772	Belongs to the SEDS family
M892_06890	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M892_06895	COG1686	Belongs to the peptidase S11 family
M892_06910	COG3547	Transposase (IS116 IS110 IS902 family)
M892_06915	COG3547	Transposase (IS116 IS110 IS902 family)
M892_06920	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M892_06925	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M892_06930	COG0366	Alpha amylase catalytic
M892_06935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M892_06935	COG1263	PTS System
M892_06945	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M892_06950	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M892_06955	COG2011	ABC-type metal ion transport system permease component
M892_06960	COG1464	Belongs to the NlpA lipoprotein family
M892_06985	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
M892_07005	COG0745	RESPONSE REGULATOR receiver
M892_07005	COG3706	GGDEF domain
M892_07010	COG1611	Belongs to the LOG family
M892_07025	COG2363	Small membrane protein
M892_07035	COG0583	DNA-binding transcription factor activity
M892_07040	COG2433	Pfam Transposase IS66
M892_07065	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M892_07075	COG0142	geranyltranstransferase activity
M892_07085	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M892_07090	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M892_07115	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M892_07115	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M892_07120	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M892_07125	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M892_07150	COG2252	PERMEase
M892_07160	COG2195	Cleaves the N-terminal amino acid of tripeptides
M892_07165	COG3385	transposase activity
M892_07185	COG3293	Transposase
M892_07195	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M892_07195	COG0047	phosphoribosylformylglycinamidine synthase activity
M892_07225	COG0590	tRNA wobble adenosine to inosine editing
M892_07235	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
M892_07275	COG1301	dicarboxylic acid transport
M892_07290	COG0497	DNA recombination
M892_07295	COG0456	acetyltransferase
M892_07300	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M892_07315	COG2914	Belongs to the UPF0125 (RnfH) family
M892_07320	COG2867	negative regulation of translational initiation
M892_07330	COG0582	viral genome integration into host DNA
M892_07345	COG3385	transposase activity
M892_07395	COG0583	DNA-binding transcription factor activity
M892_07400	COG1289	transmembrane transporter activity
M892_07415	COG2433	Pfam Transposase IS66
M892_07445	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M892_07450	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M892_07480	COG3344	reverse transcriptase
M892_07485	COG3335	DDE superfamily endonuclease
M892_07490	COG0668	transmembrane transport
M892_07495	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M892_07500	COG0583	DNA-binding transcription factor activity
M892_07505	COG1115	amino acid carrier protein
M892_07510	COG3344	reverse transcriptase
M892_07515	COG1584	GPR1 FUN34 yaaH family protein
M892_07525	COG1757	Na H antiporter
M892_07530	COG1757	Na H antiporter
M892_07540	COG0517	IMP dehydrogenase activity
M892_07540	COG0516	GMP reductase activity
M892_07560	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M892_07565	COG2976	Protein conserved in bacteria
M892_07600	COG3385	transposase activity
M892_07605	COG2975	iron-sulfur cluster assembly
M892_07610	COG0633	Ferredoxin
M892_07625	COG0316	Belongs to the HesB IscA family
M892_07630	COG0822	iron-sulfur transferase activity
M892_07645	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
M892_07660	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M892_07665	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M892_07670	COG1862	Preprotein translocase
M892_07690	COG0517	IMP dehydrogenase activity
M892_07700	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M892_07705	COG0583	DNA-binding transcription factor activity
M892_07710	COG0450	alkyl hydroperoxide reductase
M892_07725	COG3335	DDE superfamily endonuclease
M892_07735	COG0704	Plays a role in the regulation of phosphate uptake
M892_07740	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M892_07745	COG0581	inorganic phosphate transmembrane transporter activity
M892_07750	COG0573	inorganic phosphate transmembrane transporter activity
M892_07755	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M892_07760	COG0248	Ppx GppA phosphatase
M892_07770	COG5002	protein histidine kinase activity
M892_07775	COG0745	RESPONSE REGULATOR receiver
M892_07790	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M892_07815	COG3335	DDE superfamily endonuclease
M892_07825	COG3335	DDE superfamily endonuclease
M892_07875	COG0542	response to heat
M892_07885	COG0564	pseudouridine synthase activity
M892_07890	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M892_07895	COG0741	lytic transglycosylase activity
M892_07900	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M892_07905	COG0077	Prephenate dehydratase
M892_07905	COG1605	Chorismate mutase
M892_07910	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
M892_07925	COG0488	(ABC) transporter
M892_07935	COG0739	heme binding
M892_07940	COG1605	Chorismate mutase
M892_07940	COG0287	Prephenate dehydrogenase
M892_07945	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M892_07950	COG1472	Belongs to the glycosyl hydrolase 3 family
M892_07955	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M892_07975	COG1966	Carbon starvation protein
M892_07980	COG3275	phosphorelay sensor kinase activity
M892_07985	COG3279	Response regulator of the LytR AlgR family
M892_07990	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M892_07995	COG1047	Peptidyl-prolyl cis-trans
M892_08010	COG0196	riboflavin kinase activity
M892_08015	COG0728	peptidoglycan biosynthetic process
M892_08020	COG0268	Binds directly to 16S ribosomal RNA
M892_08025	COG0640	Transcriptional regulator
M892_08030	COG0583	DNA-binding transcription factor activity
M892_08035	COG1283	sodium-dependent phosphate transmembrane transporter activity
M892_08060	COG0730	response to heat
M892_08085	COG0667	Aldo Keto reductase
M892_08110	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
M892_08115	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M892_08120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M892_08130	COG0716	FMN binding
M892_08145	COG0513	Belongs to the DEAD box helicase family
M892_08160	COG3022	response to hydroperoxide
M892_08165	COG1115	amino acid carrier protein
M892_08200	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M892_08205	COG0083	homoserine kinase activity
M892_08220	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M892_08230	COG3385	transposase activity
M892_08235	COG0745	RESPONSE REGULATOR receiver
M892_08245	COG2198	Histidine kinase
M892_08245	COG0784	Response regulator, receiver
M892_08245	COG5002	protein histidine kinase activity
M892_08250	COG2203	Gaf domain
M892_08250	COG5001	Diguanylate cyclase
M892_08250	COG3706	GGDEF domain
M892_08250	COG4251	negative regulation of phosphorylation
M892_08255	COG1242	4 iron, 4 sulfur cluster binding
M892_08260	COG0067	glutamate synthase
M892_08260	COG0070	glutamate synthase
M892_08260	COG0069	glutamate synthase activity
M892_08270	COG0067	glutamate synthase
M892_08270	COG0070	glutamate synthase
M892_08270	COG0069	glutamate synthase activity
M892_08275	COG0493	'glutamate synthase
M892_08300	COG2860	membrane
M892_08305	COG0583	DNA-binding transcription factor activity
M892_08310	COG0730	response to heat
M892_08325	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M892_08330	COG0505	Belongs to the CarA family
M892_08340	COG0494	nUDIX hydrolase
M892_08360	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M892_08365	COG0849	cell division
M892_08370	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M892_08385	COG0772	Belongs to the SEDS family
M892_08400	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M892_08405	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M892_08410	COG0768	penicillin binding
M892_08415	COG3116	cell division
M892_08425	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M892_08440	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
M892_08445	COG2823	Periplasmic or secreted lipoprotein
M892_08450	COG2969	positive regulation of protein catabolic process
M892_08455	COG0625	glutathione transferase activity
M892_08460	COG2857	Cytochrome c1
M892_08465	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M892_08470	COG0723	plastoquinol--plastocyanin reductase activity
M892_08485	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M892_08490	COG3105	Protein conserved in bacteria
M892_08495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M892_08500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M892_08505	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M892_08510	COG0187	DNA topoisomerase II activity
M892_08515	COG3150	esterase
M892_08525	COG3151	Protein conserved in bacteria
M892_08530	COG0494	nUDIX hydrolase
M892_08535	COG1538	Outer membrane efflux protein
M892_08545	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M892_08555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M892_08560	COG3025	triphosphatase activity
M892_08565	COG1392	Phosphate transport regulator
M892_08570	COG0306	phosphate transporter
M892_08575	COG4991	sh3 domain protein
M892_08585	COG3409	Peptidoglycan-binding domain 1 protein
M892_08585	COG3267	Type II secretory pathway component ExeA
M892_08600	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M892_08605	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M892_08615	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M892_08620	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M892_08625	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M892_08630	COG1610	YqeY-like protein
M892_08635	COG0358	DNA primase activity
M892_08640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M892_08660	COG2433	Pfam Transposase IS66
M892_08685	COG0582	viral genome integration into host DNA
M892_08710	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M892_08710	COG2213	PTS system mannitol-specific
M892_08720	COG3722	fumarate hydratase activity
M892_08725	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M892_08730	COG1349	DNA-binding transcription factor activity
M892_08735	COG0469	pyruvate kinase activity
M892_08745	COG3706	GGDEF domain
M892_08750	COG0440	acetolactate synthase activity
M892_08755	COG0028	Belongs to the TPP enzyme family
M892_08760	COG1022	Amp-dependent synthetase and ligase
M892_08765	COG0583	DNA-binding transcription factor activity
M892_08785	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M892_08790	COG0473	3-isopropylmalate dehydrogenase activity
M892_08810	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M892_08815	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M892_08820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M892_08825	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M892_08850	COG3610	response to peptide
M892_08855	COG2966	Psort location CytoplasmicMembrane, score
M892_08870	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M892_08875	COG0142	geranyltranstransferase activity
M892_08880	COG3385	transposase activity
M892_08915	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
M892_08920	COG1178	ABC-type Fe3 transport system permease component
M892_08925	COG4143	(ABC) transporter
M892_08930	COG0163	prenyltransferase activity
M892_08935	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M892_08945	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M892_08950	COG3385	transposase activity
M892_08960	COG2105	PFAM AIG2 family protein
M892_08970	COG0729	surface antigen
M892_08975	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M892_08985	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
M892_09000	COG1136	(ABC) transporter
M892_09020	COG0529	Catalyzes the synthesis of activated sulfate
M892_09025	COG0471	metal ion transport
M892_09025	COG3273	potassium ion transport
M892_09040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M892_09040	COG1648	precorrin-2 dehydrogenase activity
M892_09045	COG0737	Belongs to the 5'-nucleotidase family
M892_09055	COG0513	Belongs to the DEAD box helicase family
M892_09060	COG2153	protein acetylation
M892_09070	COG3344	reverse transcriptase
M892_09080	COG0545	Peptidyl-prolyl cis-trans isomerase
M892_09090	COG0203	ribosomal protein L17
M892_09105	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M892_09110	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M892_09120	COG0201	protein transport
M892_09130	COG1841	ribosomal large subunit assembly
M892_09235	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M892_09240	COG1609	Transcriptional regulator
M892_09260	COG1575	Belongs to the MenA family. Type 1 subfamily
M892_09265	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M892_09275	COG1494	fructose-1,6-bisphosphatase
M892_09290	COG3547	Transposase (IS116 IS110 IS902 family)
M892_09305	COG0149	triose-phosphate isomerase activity
M892_09320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M892_09325	COG1482	cell wall glycoprotein biosynthetic process
M892_09395	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M892_09400	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M892_09435	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M892_09445	COG1560	Kdo2-lipid A biosynthetic process
M892_09455	COG1519	Transferase
M892_09465	COG1083	cytidylyl-transferase
M892_09475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M892_09495	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M892_09500	COG2089	acid synthase
M892_09525	COG3642	lipopolysaccharide core region biosynthetic process
M892_09530	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M892_09535	COG0859	PFAM glycosyl transferase family 9
M892_09540	COG0463	Glycosyl transferase, family 2
M892_09545	COG0438	transferase activity, transferring glycosyl groups
M892_09585	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M892_09595	COG1560	Kdo2-lipid A biosynthetic process
M892_09605	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M892_09610	COG1561	YicC-like family, N-terminal region
M892_09640	COG0747	negative chemotaxis
M892_09645	COG4239	(ABC) transporter, permease
M892_09650	COG4174	ABC transporter (Permease)
M892_09670	COG0811	peptide transport
M892_09675	COG0848	biopolymer transport protein
M892_09690	COG0194	GDP metabolic process
M892_09695	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M892_09700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M892_09705	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M892_09715	COG2233	PERMEase
M892_09720	COG2205	protein histidine kinase activity
M892_09730	COG0745	RESPONSE REGULATOR receiver
M892_09735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M892_09745	COG2183	response to ionizing radiation
M892_09760	COG1040	competence protein
M892_09770	COG0494	nUDIX hydrolase
M892_09775	COG1218	3'(2'),5'-bisphosphate nucleotidase
M892_09785	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
M892_09790	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
M892_09795	COG3156	type II secretion system protein K
M892_09800	COG4795	General secretion pathway protein
M892_09805	COG2165	general secretion pathway protein
M892_09810	COG2165	general secretion pathway protein
M892_09815	COG2165	general secretion pathway protein
M892_09820	COG1459	type II secretion system
M892_09825	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M892_09835	COG3031	protein transport across the cell outer membrane
M892_09840	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M892_09860	COG0456	acetyltransferase
M892_09865	COG1490	D-aminoacyl-tRNA deacylase activity
M892_09895	COG0174	glutamine synthetase
M892_09905	COG3852	Histidine kinase
M892_09910	COG2204	response regulator
M892_09920	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M892_09925	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M892_09955	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M892_09960	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M892_09960	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M892_09975	COG0084	hydrolase, TatD family'
M892_09980	COG0805	protein transport
M892_10000	COG3165	ubiquinone biosynthetic process from chorismate
M892_10010	COG1322	Protein conserved in bacteria
M892_10025	COG3385	transposase activity
M892_10030	COG3293	Transposase
M892_10035	COG1910	domain protein
M892_10070	COG3469	chitinase activity
M892_10105	COG4372	Transposase
M892_10125	COG2081	HI0933 family
M892_10140	COG1528	Iron-storage protein
M892_10150	COG0589	response to stress
M892_10155	COG0697	spore germination
M892_10170	COG5001	Diguanylate cyclase
M892_10170	COG5002	protein histidine kinase activity
M892_10175	COG1522	sequence-specific DNA binding
M892_10185	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M892_10195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M892_10225	COG0800	Aldolase
M892_10230	COG2610	gluconate transmembrane transporter activity
M892_10235	COG3265	gluconokinase activity
M892_10240	COG0129	dihydroxy-acid dehydratase activity
M892_10245	COG3547	Transposase (IS116 IS110 IS902 family)
M892_10255	COG2076	Multidrug Resistance protein
M892_10260	COG0583	DNA-binding transcription factor activity
M892_10270	COG0515	serine threonine protein kinase
M892_10295	COG3293	Transposase
M892_10310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M892_10320	COG4166	transmembrane transport
M892_10380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M892_10385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M892_10390	COG2960	long-chain fatty acid transporting porin activity
M892_10395	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M892_10400	COG0583	DNA-binding transcription factor activity
M892_10410	COG3335	DDE superfamily endonuclease
M892_10415	COG3335	DDE superfamily endonuclease
M892_10445	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M892_10450	COG1739	Uncharacterized protein family UPF0029
M892_10460	COG0183	Belongs to the thiolase family
M892_10465	COG0604	alcohol dehydrogenase
M892_10490	COG2119	membrane
M892_10505	COG3385	transposase activity
M892_10510	COG3977	Valine--pyruvate aminotransferase
M892_10515	COG0071	Belongs to the small heat shock protein (HSP20) family
M892_10525	COG0187	DNA topoisomerase II activity
M892_10535	COG0592	DNA-directed DNA polymerase activity
M892_10575	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M892_10590	COG1192	Involved in chromosome partitioning
M892_10595	COG1475	DNA binding
M892_10600	COG3312	ion transport
M892_10630	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M892_10640	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M892_10650	COG0765	amino acid transport
M892_10655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M892_10660	COG2814	Major facilitator Superfamily
M892_10665	COG0583	DNA-binding transcription factor activity
M892_10675	COG0129	dihydroxy-acid dehydratase activity
M892_10680	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M892_10685	COG3978	acetolactate synthase activity
M892_10695	COG0606	chelatase, subunit chli
M892_10700	COG2199	diguanylate cyclase activity
M892_10710	COG0204	Acyl-transferase
M892_10715	COG3385	transposase activity
M892_10720	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M892_10725	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M892_10735	COG3084	Protein conserved in bacteria
M892_10750	COG4326	sporulation control protein
M892_10755	COG1272	protein, Hemolysin III
M892_10765	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M892_10770	COG0569	domain protein
M892_10775	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M892_10775	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M892_10795	COG0758	DNA mediated transformation
M892_10805	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M892_10810	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M892_10835	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M892_10880	COG3335	DDE superfamily endonuclease
M892_10890	COG2132	Multicopper oxidase
M892_10910	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M892_10915	COG2104	thiamine diphosphate biosynthetic process
M892_10930	COG0006	proline dipeptidase activity
M892_10930	COG0006	proline dipeptidase activity
M892_10940	COG2814	Major facilitator Superfamily
M892_10960	COG3220	belongs to the UPF0276 family
M892_10970	COG0210	DNA helicase
M892_10975	COG3344	reverse transcriptase
M892_10980	COG0405	Gamma-glutamyltransferase
M892_10985	COG1280	lysine exporter protein (LysE YggA)
M892_10995	COG2962	Rard protein
M892_11000	COG0514	ATP-dependent DNA helicase (RecQ)
M892_11010	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M892_11015	COG3344	reverse transcriptase
M892_11030	COG3118	belongs to the thioredoxin family
M892_11035	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M892_11045	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
M892_11050	COG0633	Ferredoxin
M892_11080	COG3335	DDE superfamily endonuclease
M892_11095	COG3335	DDE superfamily endonuclease
M892_11105	COG3071	HemY protein
M892_11110	COG2959	enzyme of heme biosynthesis
M892_11115	COG1587	Uroporphyrinogen-III synthase
M892_11125	COG3072	Adenylate cyclase
M892_11140	COG0019	diaminopimelate decarboxylase activity
M892_11160	COG1011	Hydrolase
M892_11165	COG3287	FIST C domain
M892_11165	COG2200	EAL domain
M892_11165	COG2199	diguanylate cyclase activity
M892_11185	COG0561	phosphatase activity
M892_11190	COG2267	carboxylic ester hydrolase activity
M892_11195	COG1280	lysine exporter protein (LysE YggA)
M892_11200	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M892_11205	COG0640	Transcriptional regulator
M892_11210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M892_11245	COG3293	Transposase
M892_11270	COG2095	MarC family integral membrane protein
M892_11280	COG0742	ribosomal rna small subunit methyltransferase
M892_11285	COG0552	protein localization to endoplasmic reticulum
M892_11290	COG2884	Cell division ATP-binding protein ftsE
M892_11295	COG2177	Part of the ABC transporter FtsEX involved in
M892_11310	COG0705	Rhomboid family
M892_11315	COG1580	Controls the rotational direction of flagella during chemotaxis
M892_11320	COG3161	chorismate lyase activity
M892_11330	COG3344	reverse transcriptase
M892_11340	COG2937	Belongs to the GPAT DAPAT family
M892_11355	COG0534	Mate efflux family protein
M892_11455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M892_11460	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M892_11500	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M892_11505	COG0250	Participates in transcription elongation, termination and antitermination
M892_11520	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M892_11540	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
M892_11545	COG2816	NAD+ diphosphatase activity
M892_11565	COG1573	uracil-dna glycosylase
M892_11575	COG3068	Protein conserved in bacteria
M892_11580	COG1253	flavin adenine dinucleotide binding
M892_11595	COG0151	Belongs to the GarS family
M892_11610	COG0789	Transcriptional regulator
M892_11615	COG3710	Transcriptional regulator
M892_11620	COG0531	amino acid
M892_11625	COG1982	Orn Lys Arg decarboxylase major
M892_11680	COG3335	DDE superfamily endonuclease
M892_11685	COG3335	DDE superfamily endonuclease
M892_11695	COG3335	DDE superfamily endonuclease
M892_11700	COG1484	DNA-dependent DNA replication
M892_11705	COG4584	PFAM Integrase catalytic
M892_11720	COG2433	Pfam Transposase IS66
M892_11730	COG5001	Diguanylate cyclase
M892_11730	COG3300	MHYT domain
M892_11735	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M892_11740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M892_11750	COG0439	Biotin carboxylase
M892_11755	COG0511	ligase activity, forming carbon-carbon bonds
M892_11760	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M892_11765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M892_11780	COG2814	Major facilitator Superfamily
M892_11785	COG0784	Response regulator, receiver
M892_11785	COG2205	protein histidine kinase activity
M892_11805	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M892_11815	COG2095	MarC family integral membrane protein
M892_11825	COG4232	protein-disulfide reductase activity
M892_11830	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M892_11835	COG1027	Aspartate ammonia-lyase
M892_11840	COG3030	protein affecting phage T7 exclusion by the F plasmid
M892_11845	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M892_11855	COG2205	protein histidine kinase activity
M892_11860	COG0745	RESPONSE REGULATOR receiver
M892_11890	COG0534	Mate efflux family protein
M892_11895	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M892_11905	COG3344	reverse transcriptase
M892_11920	COG1509	lysine 2,3-aminomutase activity
M892_11950	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M892_11955	COG1053	succinate dehydrogenase
M892_11980	COG4942	peptidase
M892_11985	COG1045	serine acetyltransferase
M892_12000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M892_12020	COG0471	metal ion transport
M892_12045	COG1162	GTPase activity
M892_12115	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M892_12120	COG0802	atpase or kinase
M892_12125	COG0860	N-Acetylmuramoyl-L-alanine amidase
M892_12130	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M892_12145	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M892_12150	COG0330	HflC and HflK could
M892_12155	COG0330	HflC and HflK could
M892_12160	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
M892_12165	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M892_12170	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
M892_12175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M892_12175	COG1017	nitric oxide dioxygenase activity
M892_12185	COG0557	exoribonuclease II activity
M892_12190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M892_12195	COG0546	phosphoglycolate phosphatase activity
M892_12210	COG0512	Glutamine amidotransferase of anthranilate synthase
M892_12215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M892_12235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M892_12240	COG3954	Phosphoribulokinase
M892_12250	COG0429	hydrolase of the alpha beta-hydrolase fold
M892_12260	COG0488	(ABC) transporter
M892_12265	COG2249	NAD(P)H dehydrogenase (quinone) activity
M892_12280	COG1047	Peptidyl-prolyl cis-trans
M892_12285	COG1446	asparaginase
M892_12300	COG0545	Peptidyl-prolyl cis-trans isomerase
M892_12305	COG2964	Protein conserved in bacteria
M892_12310	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M892_12315	COG2923	Belongs to the DsrF TusC family
M892_12320	COG2168	tRNA wobble position uridine thiolation
M892_12335	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M892_12360	COG2906	2 iron, 2 sulfur cluster binding
M892_12370	COG0281	malic enzyme
M892_12380	COG0626	cystathionine gamma-synthase activity
M892_12385	COG0460	homoserine dehydrogenase
M892_12385	COG0527	aspartate kinase activity
M892_12390	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M892_12400	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
M892_12410	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M892_12425	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M892_12425	COG0165	Argininosuccinate lyase
M892_12440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M892_12445	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M892_12445	COG0678	peroxiredoxin activity
M892_12455	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M892_12500	COG0338	D12 class N6 adenine-specific DNA methyltransferase
M892_12505	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M892_12515	COG2965	DNA replication, synthesis of RNA primer
M892_12540	COG0305	Participates in initiation and elongation during chromosome replication
M892_12545	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M892_12550	COG3385	transposase activity
M892_12560	COG0432	Pfam Uncharacterised protein family UPF0047
M892_12575	COG0735	belongs to the Fur family
M892_12580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M892_12600	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M892_12635	COG3335	DDE superfamily endonuclease
M892_12650	COG0646	methionine synthase
M892_12650	COG1410	methionine synthase
M892_12655	COG0527	aspartate kinase activity
M892_12660	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M892_12670	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M892_12685	COG0629	single-stranded DNA binding
M892_12690	COG2199	diguanylate cyclase activity
M892_12690	COG2200	EAL domain
M892_12715	COG3409	Peptidoglycan-binding domain 1 protein
M892_12715	COG3267	Type II secretory pathway component ExeA
M892_12725	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M892_12730	COG1459	type II secretion system
M892_12775	COG1077	Cell shape determining protein MreB Mrl
M892_12780	COG1792	Involved in formation and maintenance of cell shape
M892_12785	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M892_12790	COG0424	maF-like protein
M892_12795	COG1530	ribonuclease E activity
M892_12800	COG3164	Protein of unknown function
M892_12805	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M892_12810	COG0312	modulator of DNA gyrase
M892_12815	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M892_12830	COG0564	pseudouridine synthase activity
M892_12835	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M892_12845	COG0312	modulator of DNA gyrase
M892_12850	COG3344	reverse transcriptase
M892_12855	COG2239	Acts as a magnesium transporter
M892_12860	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M892_12870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M892_12875	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M892_12885	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M892_12895	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M892_12895	COG0517	IMP dehydrogenase activity
M892_12905	COG1127	ABC transporter
M892_12910	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M892_12915	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M892_12920	COG2854	intermembrane phospholipid transfer
M892_12930	COG5007	Belongs to the BolA IbaG family
M892_12940	COG0204	Acyl-transferase
M892_12945	COG3344	reverse transcriptase
M892_12950	COG0251	oxidation-reduction process
M892_12995	COG0456	acetyltransferase
M892_13005	COG0525	valine-tRNA ligase activity
M892_13010	COG2927	DNA polymerase III (CHI subunit)
M892_13020	COG0795	lipopolysaccharide-transporting ATPase activity
M892_13025	COG0795	lipopolysaccharide-transporting ATPase activity
M892_13035	COG1028	Short-chain dehydrogenase reductase Sdr
M892_13060	COG0726	polysaccharide deacetylase
M892_13065	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M892_13075	COG1447	Phosphotransferase system cellobiose-specific component IIA
M892_13080	COG1486	melibiose metabolic process
M892_13095	COG3437	response regulator, receiver
M892_13130	COG1012	belongs to the aldehyde dehydrogenase family
M892_13200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M892_13205	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M892_13220	COG0762	integral membrane protein
M892_13225	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M892_13230	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M892_13245	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M892_13250	COG1678	Uncharacterized ACR, COG1678
M892_13255	COG0189	ligase activity
M892_13260	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M892_13265	COG2356	endonuclease I
M892_13285	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M892_13305	COG0191	fructose-bisphosphate aldolase activity
M892_13310	COG0668	transmembrane transport
M892_13320	COG0583	DNA-binding transcription factor activity
M892_13325	COG2968	Membrane
M892_13330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M892_13340	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M892_13345	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
M892_13355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M892_13360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M892_13380	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M892_13390	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M892_13395	COG1595	DNA-templated transcription, initiation
M892_13410	COG3086	response to oxidative stress
M892_13420	COG0681	Belongs to the peptidase S26 family
M892_13430	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M892_13435	COG1381	Involved in DNA repair and RecF pathway recombination
M892_13440	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M892_13450	COG3385	transposase activity
M892_13465	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M892_13470	COG3956	TIGRFAM MazG family protein
M892_13480	COG0148	phosphopyruvate hydratase activity
M892_13490	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M892_13520	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M892_13525	COG3385	transposase activity
M892_13535	COG1546	Belongs to the CinA family
M892_13540	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M892_13555	COG0527	aspartate kinase activity
M892_13635	COG5016	pyruvate
M892_13635	COG0511	ligase activity, forming carbon-carbon bonds
M892_13640	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
M892_13650	COG1238	metal cluster binding
M892_13655	COG0612	Peptidase, M16
M892_13675	COG4536	flavin adenine dinucleotide binding
M892_13680	COG4137	Cytochrome C assembly protein
M892_13685	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M892_13710	COG3547	Transposase (IS116 IS110 IS902 family)
M892_13715	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
M892_13720	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
M892_13725	COG0237	dephospho-CoA kinase activity
M892_13735	COG1459	type II secretion system
M892_13765	COG2186	Transcriptional regulator
M892_13770	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M892_13775	COG0508	dehydrogenase complex catalyzes the overall conversion of
M892_13780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M892_13805	COG0288	reversible hydration of carbon dioxide
M892_13810	COG0659	secondary active sulfate transmembrane transporter activity
M892_13815	COG1131	(ABC) transporter
M892_13820	COG0842	Transport permease protein
M892_13830	COG1560	Kdo2-lipid A biosynthetic process
M892_13845	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M892_13855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M892_13860	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M892_13870	COG1643	Atp-dependent helicase
M892_13875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M892_13880	COG1752	Esterase of the alpha-beta hydrolase superfamily
M892_13885	COG1049	propionate catabolic process, 2-methylcitrate cycle
M892_13890	COG3547	Transposase (IS116 IS110 IS902 family)
M892_13910	COG0004	ammonium transporteR
M892_13915	COG1840	ABC-type Fe3 transport system, periplasmic component
M892_13925	COG3842	ATPase activity
M892_13930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M892_13945	COG2971	BadF BadG BcrA BcrD
M892_13955	COG4608	Belongs to the ABC transporter superfamily
M892_13960	COG0444	Belongs to the ABC transporter superfamily
M892_13965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M892_13975	COG0747	negative chemotaxis
M892_13980	COG2198	Histidine kinase
M892_13980	COG0784	Response regulator, receiver
M892_13980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M892_13980	COG2205	protein histidine kinase activity
M892_13990	COG0628	permease
M892_14020	COG0739	heme binding
M892_14025	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M892_14040	COG2027	D-alanyl-D-alanine carboxypeptidase
M892_14045	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M892_14050	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M892_14055	COG1534	Rna-binding protein
M892_14065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M892_14070	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M892_14085	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M892_14105	COG0195	Participates in both transcription termination and antitermination
M892_14125	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M892_14145	COG0534	Mate efflux family protein
M892_14170	COG3153	acetyltransferase
M892_14200	COG0084	hydrolase, TatD family'
M892_14205	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M892_14215	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M892_14225	COG0813	purine-nucleoside phosphorylase activity
M892_14235	COG0560	Phosphoserine phosphatase
M892_14245	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M892_14250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M892_14280	COG1022	Amp-dependent synthetase and ligase
M892_14285	COG0741	lytic transglycosylase activity
M892_14290	COG0583	DNA-binding transcription factor activity
M892_14310	COG2433	Pfam Transposase IS66
M892_14330	COG4964	Belongs to the GSP D family
M892_14395	COG0583	DNA-binding transcription factor activity
M892_14400	COG0531	amino acid
M892_14405	COG2731	YhcH YjgK YiaL family protein
M892_14410	COG3250	beta-galactosidase activity
M892_14415	COG3250	beta-galactosidase activity
M892_14420	COG3250	beta-galactosidase activity
M892_14425	COG1609	Transcriptional regulator
M892_14430	COG0768	penicillin binding
M892_14440	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M892_14445	COG3547	Transposase (IS116 IS110 IS902 family)
M892_14450	COG1085	galactose-1-phosphate uridylyltransferase
M892_14465	COG2017	converts alpha-aldose to the beta-anomer
M892_14470	COG1609	Transcriptional regulator
M892_14475	COG1263	PTS System
M892_14475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M892_14490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M892_14520	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M892_14525	COG1349	DNA-binding transcription factor activity
M892_14535	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M892_14540	COG2271	Major facilitator Superfamily
M892_14545	COG0584	glycerophosphoryl diester phosphodiesterase
M892_14550	COG2171	N-acyltransferase activity
M892_14570	COG3141	response to X-ray
M892_14590	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M892_14600	COG1074	ATP-dependent DNA helicase activity
M892_14605	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M892_14620	COG3385	transposase activity
M892_14630	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M892_14630	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M892_14645	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M892_14650	COG2166	iron-sulfur cluster assembly
M892_14655	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M892_14660	COG0693	protein deglycase activity
M892_14665	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M892_14685	COG1595	DNA-templated transcription, initiation
M892_14715	COG0271	Belongs to the BolA IbaG family
M892_14750	COG1477	protein flavinylation
M892_14765	COG0745	RESPONSE REGULATOR receiver
M892_14765	COG3706	GGDEF domain
M892_14770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M892_14775	COG0514	ATP-dependent DNA helicase (RecQ)
M892_14780	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M892_14790	COG3385	transposase activity
M892_14800	COG0733	neurotransmitter:sodium symporter activity
M892_14825	COG1720	tRNA m6t6A37 methyltransferase activity
M892_14835	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
M892_14865	COG3098	single-species biofilm formation
M892_14870	COG0564	pseudouridine synthase activity
M892_14885	COG0024	Methionine aminopeptidase
M892_14910	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M892_14915	COG0575	Belongs to the CDS family
M892_14925	COG0750	zinc metalloprotease
M892_14935	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
M892_14940	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M892_14965	COG0587	DNA-directed DNA polymerase activity
M892_14985	COG0347	Belongs to the P(II) protein family
M892_15000	COG1388	LysM domain
M892_15000	COG0741	lytic transglycosylase activity
M892_15010	COG2226	methyltransferase
M892_15020	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M892_15045	COG1960	acyl-CoA dehydrogenase activity
M892_15050	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
M892_15055	COG0121	glutamine amidotransferase
M892_15060	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M892_15070	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M892_15075	COG2233	PERMEase
M892_15095	COG1393	Belongs to the ArsC family
M892_15100	COG4783	chaperone-mediated protein folding
M892_15120	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M892_15125	COG2716	regulation of RNA biosynthetic process
M892_15130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M892_15155	COG1393	Belongs to the ArsC family
M892_15180	COG2837	iron assimilation
M892_15195	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M892_15200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M892_15205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M892_15210	COG1334	flagellar protein FlaG
M892_15215	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M892_15225	COG1516	flagellar protein fliS
M892_15230	COG2204	response regulator
M892_15235	COG4191	Histidine kinase
M892_15240	COG2204	response regulator
M892_15245	COG1677	Flagellar hook-basal body complex protein FliE
M892_15255	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M892_15310	COG1987	bacterial-type flagellum assembly
M892_15315	COG1684	flagellar biosynthetic protein fliR
M892_15335	COG0455	bacterial-type flagellum organization
M892_15350	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
M892_15355	COG0643	Histidine kinase
M892_15355	COG2198	Histidine kinase
M892_15360	COG2201	protein-glutamate methylesterase activity
M892_15365	COG1192	Involved in chromosome partitioning
M892_15375	COG0835	chemotaxis
M892_15385	COG4133	protoheme IX ABC transporter activity
M892_15390	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M892_15395	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M892_15410	COG1138	Cytochrome C-type biogenesis protein
M892_15415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M892_15425	COG4235	cytochrome complex assembly
M892_15425	COG3088	subunit of a heme lyase
M892_15430	COG2853	Lipoprotein
M892_15435	COG2067	long-chain fatty acid transport protein
M892_15440	COG2067	long-chain fatty acid transport protein
M892_15455	COG0183	Belongs to the thiolase family
M892_15460	COG3344	reverse transcriptase
M892_15470	COG2062	phosphohistidine phosphatase, SixA
M892_15480	COG2890	protein-(glutamine-N5) methyltransferase activity
M892_15495	COG2860	membrane
M892_15500	COG3101	peptidyl-lysine hydroxylation
M892_15525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M892_15530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M892_15535	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M892_15560	COG0285	dihydrofolate synthase activity
M892_15565	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
M892_15570	COG1286	toxin biosynthetic process
M892_15575	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M892_15580	COG3385	transposase activity
M892_15585	COG0583	DNA-binding transcription factor activity
M892_15590	COG0745	RESPONSE REGULATOR receiver
M892_15600	COG2832	Protein of unknown function (DUF454)
M892_15610	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M892_15620	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M892_15625	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M892_15630	COG0251	oxidation-reduction process
M892_15640	COG2964	Protein conserved in bacteria
M892_15705	COG2261	transglycosylase associated protein
M892_15710	COG2985	domain, Protein
M892_15715	COG0076	glutamate decarboxylase activity
M892_15720	COG0668	transmembrane transport
M892_15730	COG0346	lactoylglutathione lyase activity
M892_15745	COG1785	Belongs to the alkaline phosphatase family
M892_15765	COG2226	methyltransferase
M892_15785	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M892_15790	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M892_15800	COG3139	Protein of unknown function (DUF1315)
M892_15805	COG0252	asparaginase activity
M892_15810	COG0616	signal peptide processing
M892_15815	COG0446	pyridine nucleotide-disulphide oxidoreductase
M892_15815	COG1902	pentaerythritol trinitrate reductase activity
M892_15820	COG0778	Nitroreductase
M892_15825	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M892_15850	COG0123	including yeast histone deacetylase and acetoin utilization protein
M892_15860	COG4269	membrane
M892_15870	COG3385	transposase activity
M892_15880	COG3083	sulfuric ester hydrolase activity
M892_15895	COG3385	transposase activity
M892_15910	COG1757	Na H antiporter
M892_15915	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M892_15920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M892_15925	COG2095	MarC family integral membrane protein
M892_15930	COG1012	belongs to the aldehyde dehydrogenase family
M892_15930	COG1454	alcohol dehydrogenase
M892_15935	COG3344	reverse transcriptase
M892_15940	COG1028	Short-chain dehydrogenase reductase Sdr
M892_15955	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M892_15970	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M892_15990	COG3706	GGDEF domain
M892_15990	COG0745	RESPONSE REGULATOR receiver
M892_16005	COG2433	Pfam Transposase IS66
M892_16015	COG3451	type IV secretory pathway VirB4
M892_16050	COG2056	Na+-H+ antiporter family
M892_16060	COG2885	chlorophyll binding
M892_16070	COG0346	lactoylglutathione lyase activity
M892_16075	COG3344	reverse transcriptase
M892_16080	COG0840	transmembrane signaling receptor activity
M892_16100	COG2433	Pfam Transposase IS66
M892_16125	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M892_16130	COG4660	Part of a membrane complex involved in electron transport
M892_16135	COG4659	FMN binding
M892_16140	COG4658	electron transport chain
M892_16145	COG4656	Part of a membrane complex involved in electron transport
M892_16160	COG1882	Formate acetyltransferase
M892_16170	COG0556	nucleotide-excision repair
M892_16195	COG2433	Pfam Transposase IS66
M892_16200	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M892_16205	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M892_16210	COG0521	Mo-molybdopterin cofactor biosynthetic process
M892_16220	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M892_16225	COG0314	molybdopterin synthase activity
M892_16235	COG0601	transmembrane transport
M892_16240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M892_16250	COG0435	Glutathione S-transferase
M892_16255	COG0857	belongs to the CobB CobQ family
M892_16255	COG0280	phosphate acetyltransferase
M892_16275	COG4120	Belongs to the binding-protein-dependent transport system permease family
M892_16280	COG1122	ATPase activity
M892_16295	COG3706	GGDEF domain
M892_16295	COG0745	RESPONSE REGULATOR receiver
M892_16300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M892_16305	COG0653	protein targeting
M892_16310	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M892_16320	COG2186	Transcriptional regulator
M892_16350	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
M892_16355	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M892_16360	COG0659	secondary active sulfate transmembrane transporter activity
M892_16370	COG1530	ribonuclease E activity
M892_16375	COG0564	pseudouridine synthase activity
M892_16390	COG0424	maF-like protein
M892_16395	COG1399	metal-binding, possibly nucleic acid-binding protein
M892_16410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M892_16440	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M892_16455	COG0084	hydrolase, TatD family'
M892_16460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M892_16460	COG1263	PTS System
M892_16470	COG3385	transposase activity
M892_16480	COG0733	neurotransmitter:sodium symporter activity
M892_16495	COG4667	esterase of the alpha-beta hydrolase superfamily
M892_16555	COG2272	Belongs to the type-B carboxylesterase lipase family
M892_16585	COG2433	Pfam Transposase IS66
M892_16600	COG1940	carbohydrate kinase activity
M892_16605	COG0784	Response regulator, receiver
M892_16605	COG0835	chemotaxis
M892_16625	COG1028	Short-chain dehydrogenase reductase Sdr
M892_16630	COG0616	signal peptide processing
M892_16640	COG0539	negative regulation of cytoplasmic translation
M892_16650	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
M892_16655	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
M892_16665	COG4166	transmembrane transport
M892_16680	COG3009	Protein conserved in bacteria
M892_16685	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M892_16685	COG3008	intermembrane lipid transfer
M892_16690	COG2995	paraquat-inducible protein a
M892_16705	COG4232	protein-disulfide reductase activity
M892_16720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M892_16745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M892_16765	COG1136	(ABC) transporter
M892_16765	COG0577	efflux transmembrane transporter activity
M892_16785	COG2176	DNA-directed DNA polymerase activity
M892_16850	COG3547	Transposase (IS116 IS110 IS902 family)
M892_16890	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M892_16895	COG3547	Transposase (IS116 IS110 IS902 family)
M892_16925	COG5002	protein histidine kinase activity
M892_16925	COG3850	Histidine kinase
M892_16930	COG0745	RESPONSE REGULATOR receiver
M892_16935	COG0463	Glycosyl transferase, family 2
M892_16940	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M892_16950	COG0840	transmembrane signaling receptor activity
M892_16955	COG2175	clavaminate synthase activity
M892_16965	COG2964	Protein conserved in bacteria
M892_16970	COG0251	oxidation-reduction process
M892_16980	COG0446	pyridine nucleotide-disulphide oxidoreductase
M892_16995	COG1032	radical SAM domain protein
M892_17000	COG5001	Diguanylate cyclase
M892_17000	COG1716	ATPase activity
M892_17015	COG0583	DNA-binding transcription factor activity
M892_17030	COG2350	Protein conserved in bacteria
M892_17035	COG1607	acyl-coa hydrolase
M892_17060	COG1301	dicarboxylic acid transport
M892_17065	COG0159	tryptophan synthase activity
M892_17075	COG0135	phosphoribosylanthranilate isomerase activity
M892_17075	COG0134	indole-3-glycerol-phosphate synthase activity
M892_17085	COG0512	Glutamine amidotransferase of anthranilate synthase
M892_17090	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M892_17100	COG0613	PHP domain protein
M892_17105	COG0009	L-threonylcarbamoyladenylate synthase
M892_17115	COG1187	pseudouridine synthase activity
M892_17135	COG0417	DNA replication proofreading
M892_17140	COG2197	response regulator
M892_17170	COG0019	diaminopimelate decarboxylase activity
M892_17190	COG1546	Belongs to the CinA family
M892_17190	COG1058	Belongs to the CinA family
M892_17200	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M892_17205	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M892_17235	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
M892_17245	COG0437	4 iron, 4 sulfur cluster binding
M892_17250	COG0437	4 iron, 4 sulfur cluster binding
M892_17255	COG3301	Polysulphide reductase, NrfD
M892_17260	COG1138	Cytochrome C-type biogenesis protein
M892_17270	COG4235	cytochrome complex assembly
M892_17270	COG3088	subunit of a heme lyase
M892_17305	COG2989	Protein conserved in bacteria
M892_17310	COG3108	Peptidase M15
M892_17315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M892_17725	COG3344	reverse transcriptase
M892_17730	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M892_17765	COG2433	Pfam Transposase IS66
M892_17825	COG2433	Pfam Transposase IS66
M892_17830	COG3335	DDE superfamily endonuclease
M892_17860	COG2433	Pfam Transposase IS66
M892_17865	COG1484	DNA-dependent DNA replication
M892_17875	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M892_17910	COG3385	transposase activity
M892_17920	COG5001	Diguanylate cyclase
M892_17925	COG3335	DDE superfamily endonuclease
M892_17945	COG1609	Transcriptional regulator
M892_17965	COG0395	ABC-type sugar transport system, permease component
M892_17970	COG2723	6-phospho-beta-galactosidase activity
M892_17975	COG3842	ATPase activity
M892_17985	COG0534	Mate efflux family protein
M892_17990	COG0564	pseudouridine synthase activity
M892_17995	COG0561	phosphatase activity
M892_18005	COG2199	diguanylate cyclase activity
M892_18015	COG3152	Membrane
M892_18030	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M892_18050	COG0583	DNA-binding transcription factor activity
M892_18110	COG2076	Multidrug Resistance protein
M892_18125	COG1357	PFAM Pentapeptide repeats (8 copies)
M892_18130	COG3047	cAMP biosynthetic process
M892_18140	COG2814	Major facilitator Superfamily
M892_18160	COG3408	Glycogen debranching enzyme
M892_18160	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
M892_18215	COG2433	Pfam Transposase IS66
M892_18250	COG3344	reverse transcriptase
M892_18265	COG3835	regulator
M892_18270	COG1929	Belongs to the glycerate kinase type-1 family
M892_18275	COG0477	Major facilitator Superfamily
M892_18295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M892_18340	COG1028	Short-chain dehydrogenase reductase Sdr
M892_18350	COG3005	denitrification pathway
M892_18355	COG0243	molybdopterin cofactor binding
M892_18360	COG0671	phosphoesterase, PA-phosphatase related
M892_18375	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M892_18380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M892_18385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M892_18390	COG1116	anion transmembrane transporter activity
M892_18395	COG0351	phosphomethylpyrimidine kinase
M892_18400	COG0312	modulator of DNA gyrase
M892_18405	COG0312	modulator of DNA gyrase
M892_18470	COG2433	Pfam Transposase IS66
M892_18480	COG4974	Belongs to the 'phage' integrase family
M892_18545	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
M892_18595	COG2433	Pfam Transposase IS66
M892_18615	COG2433	Pfam Transposase IS66
M892_18640	COG3547	Transposase (IS116 IS110 IS902 family)
M892_18680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M892_18690	COG0584	glycerophosphoryl diester phosphodiesterase
M892_18695	COG0745	RESPONSE REGULATOR receiver
M892_18715	COG0811	peptide transport
M892_18720	COG0811	peptide transport
M892_18725	COG0848	biopolymer transport protein
M892_18750	COG3344	reverse transcriptase
M892_18780	COG0803	Belongs to the bacterial solute-binding protein 9 family
M892_18785	COG1121	(ABC) transporter
M892_18790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M892_18805	COG1770	oligopeptidase
M892_18810	COG2814	Major facilitator Superfamily
M892_18815	COG0010	Belongs to the arginase family
M892_18820	COG1166	arginine decarboxylase activity
M892_18830	COG4067	protein conserved in archaea
M892_18830	COG0189	ligase activity
M892_18835	COG0189	ligase activity
M892_18875	COG2723	6-phospho-beta-galactosidase activity
M892_18890	COG1114	Component of the transport system for branched-chain amino acids
M892_18910	COG0579	oxidoreductase
M892_18930	COG3033	Beta-eliminating lyase
M892_18960	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M892_18995	COG3706	GGDEF domain
M892_19000	COG0415	Belongs to the DNA photolyase family
M892_19005	COG3046	protein related to deoxyribodipyrimidine photolyase
M892_19020	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M892_19020	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M892_19025	COG1765	OsmC-like protein
M892_19060	COG1011	Hydrolase
M892_19070	COG3335	DDE superfamily endonuclease
M892_19120	COG1596	polysaccharide export
M892_19130	COG2095	MarC family integral membrane protein
M892_19135	COG4667	esterase of the alpha-beta hydrolase superfamily
M892_19145	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
M892_19150	COG0415	Belongs to the DNA photolyase family
M892_19170	COG1686	Belongs to the peptidase S11 family
M892_19180	COG0583	DNA-binding transcription factor activity
M892_19185	COG4628	conserved protein (DUF2132)
M892_19195	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M892_19210	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M892_19215	COG0628	permease
M892_19230	COG1566	PFAM secretion protein HlyD family protein
M892_19250	COG2988	succinylglutamate desuccinylase activity
M892_19260	COG2814	Major facilitator Superfamily
M892_19270	COG0148	phosphopyruvate hydratase activity
M892_19275	COG0454	-acetyltransferase
M892_19285	COG0745	RESPONSE REGULATOR receiver
M892_19290	COG2205	protein histidine kinase activity
M892_19315	COG0384	phenazine biosynthesis protein PhzF
M892_19320	COG0346	lactoylglutathione lyase activity
M892_19335	COG0488	(ABC) transporter
M892_19340	COG4628	conserved protein (DUF2132)
M892_19345	COG3344	reverse transcriptase
M892_19360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M892_19365	COG1280	lysine exporter protein (LysE YggA)
M892_19380	COG3537	Alpha-1,2-mannosidase
M892_19385	COG3537	Alpha-1,2-mannosidase
M892_19400	COG3537	Alpha-1,2-mannosidase
M892_19410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M892_19425	COG3335	DDE superfamily endonuclease
M892_19430	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M892_19430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M892_19440	COG0346	lactoylglutathione lyase activity
M892_19445	COG1349	DNA-binding transcription factor activity
M892_19460	COG0753	catalase activity
M892_19475	COG1335	isochorismatase
M892_19500	COG3136	membrane protein required for alginate biosynthesis
M892_19510	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
M892_19520	COG0583	DNA-binding transcription factor activity
M892_19540	COG4175	Glycine betaine
M892_19540	COG3448	diguanylate cyclase activity
M892_19545	COG4176	ABC-type proline glycine betaine transport system permease component
M892_19565	COG4948	Mandelate Racemase Muconate Lactonizing
M892_19610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M892_19625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M892_19645	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M892_19680	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M892_19695	COG3335	DDE superfamily endonuclease
M892_19710	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M892_19715	COG2197	response regulator
M892_19725	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M892_19725	COG0574	Belongs to the PEP-utilizing enzyme family
M892_19735	COG0252	asparaginase activity
M892_19755	COG0583	DNA-binding transcription factor activity
M892_19770	COG2321	neutral zinc metallopeptidase
M892_19775	COG3122	Protein conserved in bacteria
M892_19790	COG2255	four-way junction helicase activity
M892_19800	COG3853	Toxic anion resistance protein (TelA)
M892_19810	COG1902	pentaerythritol trinitrate reductase activity
M892_19820	COG2814	Major facilitator Superfamily
M892_19825	COG1028	Short-chain dehydrogenase reductase Sdr
M892_19870	COG2433	Pfam Transposase IS66
M892_19875	COG0513	Belongs to the DEAD box helicase family
M892_19920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M892_19940	COG3746	phosphate-selective porin O and P
M892_19965	COG1028	Short-chain dehydrogenase reductase Sdr
M892_19975	COG2274	protein secretion by the type I secretion system
M892_20035	COG2433	Pfam Transposase IS66
M892_20070	COG0625	glutathione transferase activity
M892_20075	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M892_20080	COG1686	Belongs to the peptidase S11 family
M892_20090	COG2226	methyltransferase
M892_20105	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M892_20125	COG1278	Cold shock
M892_20130	COG1741	Belongs to the pirin family
M892_20135	COG4667	esterase of the alpha-beta hydrolase superfamily
M892_20145	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M892_20155	COG0523	cobalamin synthesis protein
M892_20165	COG1846	Transcriptional regulator
M892_20195	COG2433	Pfam Transposase IS66
M892_20210	COG3842	ATPase activity
M892_20215	COG0395	ABC-type sugar transport system, permease component
M892_20220	COG1175	transmembrane transport
M892_20230	COG0584	glycerophosphoryl diester phosphodiesterase
M892_20240	COG3385	transposase activity
M892_20245	COG0589	response to stress
M892_20260	COG1505	serine-type exopeptidase activity
M892_20275	COG3344	reverse transcriptase
M892_20280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M892_20290	COG3335	DDE superfamily endonuclease
M892_20295	COG1858	cytochrome C peroxidase
M892_20310	COG0494	nUDIX hydrolase
M892_20320	COG0583	DNA-binding transcription factor activity
M892_20325	COG1280	lysine exporter protein (LysE YggA)
M892_20335	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M892_20355	COG3383	formate dehydrogenase (NAD+) activity
M892_20370	COG0842	Transport permease protein
M892_20375	COG1131	(ABC) transporter
M892_20385	COG0837	glucose binding
M892_20385	COG1737	Transcriptional regulator
M892_20400	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
M892_20410	COG3335	DDE superfamily endonuclease
M892_20415	COG4145	pantothenate transmembrane transporter activity
M892_20420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M892_20425	COG0800	Aldolase
M892_20435	COG0800	Aldolase
M892_20445	COG2706	6-phosphogluconolactonase activity
M892_20450	COG0251	oxidation-reduction process
M892_20455	COG1881	PFAM PEBP family protein
M892_20470	COG0798	PFAM Bile acid sodium symporter
M892_20485	COG1733	regulation of RNA biosynthetic process
M892_20490	COG3344	reverse transcriptase
M892_20540	COG0814	amino acid
M892_20555	COG3335	DDE superfamily endonuclease
M892_20580	COG0739	heme binding
M892_20585	COG5001	Diguanylate cyclase
M892_20590	COG1120	ATPase activity
M892_20615	COG0583	DNA-binding transcription factor activity
M892_20620	COG2814	Major facilitator Superfamily
M892_20640	COG0697	spore germination
M892_20665	COG0179	Fumarylacetoacetate (FAA) hydrolase
M892_20685	COG1280	lysine exporter protein (LysE YggA)
M892_20690	COG3385	transposase activity
M892_20700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M892_20710	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M892_20715	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
M892_20720	COG1845	cytochrome c oxidase, subunit III
M892_20740	COG1612	heme a metabolic process
M892_20755	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M892_20765	COG2814	Major facilitator Superfamily
M892_20775	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M892_20800	COG2897	thiosulfate sulfurtransferase activity
M892_20810	COG2801	Transposase and inactivated derivatives
M892_20815	COG2963	transposase activity
M892_20860	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M892_20865	COG0303	'Molybdopterin
M892_20895	COG4989	oxidoreductase activity
M892_20910	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M892_20910	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M892_20935	COG1061	Type III restriction enzyme res subunit
M892_21005	COG0583	DNA-binding transcription factor activity
M892_21025	COG4964	Belongs to the GSP D family
M892_21035	COG0455	bacterial-type flagellum organization
M892_21075	COG2885	chlorophyll binding
M892_21120	COG4176	ABC-type proline glycine betaine transport system permease component
M892_21125	COG0517	IMP dehydrogenase activity
M892_21125	COG4175	Glycine betaine
M892_21135	COG0330	HflC and HflK could
M892_21170	COG3344	reverse transcriptase
M892_21200	COG0586	Pfam SNARE associated Golgi protein
M892_21235	COG5001	Diguanylate cyclase
M892_21245	COG1129	ABC transporter
M892_21250	COG1172	Belongs to the binding-protein-dependent transport system permease family
M892_21255	COG1879	ABC-type sugar transport system periplasmic component
M892_21260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M892_21265	COG1609	Transcriptional regulator
M892_21280	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
M892_21295	COG4607	ABC-type enterochelin transport system periplasmic component
M892_21300	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M892_21305	COG4605	iron ion homeostasis
M892_21310	COG4604	ABC transporter, ATP-binding protein
M892_21315	COG0789	Transcriptional regulator
M892_21340	COG1289	transmembrane transporter activity
M892_21345	COG0210	DNA helicase
M892_21355	COG1879	ABC-type sugar transport system periplasmic component
M892_21365	COG2198	Histidine kinase
M892_21365	COG2205	protein histidine kinase activity
M892_21365	COG0784	Response regulator, receiver
M892_21425	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M892_21435	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M892_21465	COG3069	C4-dicarboxylate transmembrane transporter activity
M892_21485	COG3335	DDE superfamily endonuclease
M892_21500	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M892_21565	COG0717	Belongs to the dCTP deaminase family
M892_21570	COG0717	Belongs to the dCTP deaminase family
M892_21590	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M892_21610	COG4584	PFAM Integrase catalytic
M892_21615	COG1484	DNA-dependent DNA replication
M892_21620	COG2433	Pfam Transposase IS66
M892_21665	COG3335	DDE superfamily endonuclease
M892_21705	COG2814	Major facilitator Superfamily
M892_21750	COG1132	(ABC) transporter
M892_21770	COG0583	DNA-binding transcription factor activity
M892_21810	COG1120	ATPase activity
M892_21815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M892_21820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M892_21825	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M892_21855	COG3335	DDE superfamily endonuclease
M892_21900	COG1388	LysM domain
M892_21900	COG1470	cell adhesion involved in biofilm formation
M892_21940	COG1470	cell adhesion involved in biofilm formation
M892_21940	COG1388	LysM domain
M892_21965	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M892_21975	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M892_21980	COG3385	transposase activity
M892_21990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M892_21995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M892_22015	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
M892_22015	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M892_22015	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M892_22020	COG1105	Belongs to the carbohydrate kinase PfkB family
M892_22025	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M892_22025	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M892_22030	COG1609	Transcriptional regulator
M892_22045	COG2203	Gaf domain
M892_22045	COG2200	EAL domain
M892_22045	COG2199	diguanylate cyclase activity
M892_22050	COG0765	amino acid transport
M892_22055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M892_22060	COG0765	amino acid transport
M892_22065	COG1126	abc transporter atp-binding protein
M892_22075	COG1979	alcohol dehydrogenase
M892_22080	COG2207	Transcriptional regulator
M892_22090	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M892_22100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M892_22120	COG0546	phosphoglycolate phosphatase activity
M892_22135	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
M892_22140	COG0513	Belongs to the DEAD box helicase family
M892_22145	COG4943	cyclic-guanylate-specific phosphodiesterase activity
M892_22160	COG2433	Pfam Transposase IS66
M892_22180	COG3038	cytochrome b561
M892_22190	COG2116	formate transmembrane transporter activity
M892_22195	COG0583	DNA-binding transcription factor activity
M892_22205	COG3344	reverse transcriptase
M892_22210	COG3593	DNA synthesis involved in DNA repair
M892_22215	COG0737	Belongs to the 5'-nucleotidase family
M892_22225	COG0861	Integral membrane protein TerC family
M892_22235	COG3385	transposase activity
M892_22250	COG2433	Pfam Transposase IS66
M892_22270	COG3469	chitinase activity
M892_22280	COG3335	DDE superfamily endonuclease
M892_22285	COG2197	response regulator
M892_22290	COG3335	DDE superfamily endonuclease
M892_22295	COG0778	Nitroreductase
M892_22300	COG0784	Response regulator, receiver
M892_22300	COG0835	chemotaxis
M892_22310	COG2962	Rard protein
M892_22320	COG0671	phosphoesterase, PA-phosphatase related
M892_22330	COG3385	transposase activity
M892_22355	COG2204	response regulator
M892_22370	COG3501	Rhs element vgr protein
M892_22395	COG0515	serine threonine protein kinase
M892_22430	COG1522	sequence-specific DNA binding
M892_22485	COG4771	TonB-dependent receptor
M892_22545	COG1388	LysM domain
M892_22545	COG1470	cell adhesion involved in biofilm formation
M892_22595	COG2433	Pfam Transposase IS66
M892_22600	COG0646	methionine synthase
M892_22600	COG1410	methionine synthase
M892_22615	COG2267	carboxylic ester hydrolase activity
M892_22620	COG2067	long-chain fatty acid transport protein
M892_22630	COG0501	Belongs to the peptidase M48B family
M892_22635	COG2050	protein possibly involved in aromatic compounds catabolism
M892_22645	COG4533	DNA binding
M892_22680	COG5001	Diguanylate cyclase
M892_22680	COG3300	MHYT domain
M892_22685	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M892_22695	COG4181	ATPase activity
M892_22700	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M892_22710	COG1984	allophanate hydrolase subunit 2
M892_22715	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M892_22725	COG3447	MASE1 domain protein
M892_22725	COG5002	protein histidine kinase activity
M892_22725	COG5001	Diguanylate cyclase
M892_22730	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M892_22735	COG3385	transposase activity
M892_22745	COG0583	DNA-binding transcription factor activity
M892_22750	COG0045	succinate-CoA ligase (ADP-forming) activity
M892_22750	COG1042	CoA-binding domain protein
M892_22750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M892_22770	COG0023	Translation Initiation Factor
M892_22945	COG3385	transposase activity
M892_22950	COG3140	Belongs to the UPF0181 family
M892_22975	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
M892_22980	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M892_22995	COG0745	RESPONSE REGULATOR receiver
M892_22995	COG3706	GGDEF domain
M892_23000	COG5001	Diguanylate cyclase
M892_23000	COG4251	negative regulation of phosphorylation
M892_23000	COG3706	GGDEF domain
M892_23000	COG2203	Gaf domain
M892_23010	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M892_23015	COG4149	molybdate abc transporter
M892_23020	COG0725	ABC transporter, periplasmic molybdate-binding protein
M892_23030	COG3111	PFAM Bacterial OB fold (BOF) protein
M892_23070	COG0534	Mate efflux family protein
M892_23075	COG0602	queuosine metabolic process
M892_23080	COG1328	CTP reductase activity
M892_23145	COG3385	transposase activity
M892_23150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M892_23155	COG3118	belongs to the thioredoxin family
M892_23160	COG2814	Major facilitator Superfamily
M892_23165	COG3335	DDE superfamily endonuclease
M892_23185	COG0840	transmembrane signaling receptor activity
M892_23190	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M892_23260	COG0277	FAD linked oxidase domain protein
M892_23280	COG2425	protein containing a von Willebrand factor type A (vWA) domain
M892_23295	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
M892_23305	COG1288	antiporter activity
M892_23310	COG1288	antiporter activity
M892_23320	COG3040	lipid binding
M892_23340	COG3335	DDE superfamily endonuclease
M892_23355	COG3469	chitinase activity
M892_23365	COG0419	ATPase involved in DNA repair
M892_23370	COG0420	3'-5' exonuclease activity
M892_23400	COG0840	transmembrane signaling receptor activity
M892_23405	COG3335	DDE superfamily endonuclease
M892_23425	COG0346	lactoylglutathione lyase activity
M892_23430	COG1902	pentaerythritol trinitrate reductase activity
M892_23440	COG2755	lipolytic protein G-D-S-L family
M892_23440	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M892_23480	COG3385	transposase activity
M892_23495	COG2433	Pfam Transposase IS66
M892_23500	COG0739	heme binding
M892_23540	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
M892_23575	COG3335	DDE superfamily endonuclease
M892_23585	COG3335	DDE superfamily endonuclease
M892_23590	COG0739	heme binding
M892_23635	COG2146	nitrite reductase [NAD(P)H] activity
M892_23635	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M892_23640	COG1116	anion transmembrane transporter activity
M892_23645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M892_23650	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M892_23650	COG1116	anion transmembrane transporter activity
M892_23670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M892_23670	COG1648	precorrin-2 dehydrogenase activity
M892_23675	COG0243	molybdopterin cofactor binding
M892_23685	COG0814	amino acid
M892_23695	COG3706	GGDEF domain
M892_23720	COG3385	transposase activity
M892_23730	COG0745	RESPONSE REGULATOR receiver
M892_23775	COG3547	Transposase (IS116 IS110 IS902 family)
M892_23780	COG0443	Heat shock 70 kDa protein
M892_23810	COG3547	Transposase (IS116 IS110 IS902 family)
M892_23830	COG2200	EAL domain
M892_23835	COG3335	DDE superfamily endonuclease
M892_23855	COG0431	NADPH-dependent FMN reductase
M892_23855	COG3976	FMN-binding domain protein
M892_23855	COG1053	succinate dehydrogenase
M892_23875	COG4160	amino acid transport
M892_23880	COG4215	(ABC) transporter
M892_23885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M892_23890	COG1126	abc transporter atp-binding protein
M892_23920	COG2433	Pfam Transposase IS66
M892_23960	COG4372	Transposase
M892_23990	COG1012	belongs to the aldehyde dehydrogenase family
M892_24005	COG1902	pentaerythritol trinitrate reductase activity
M892_24005	COG0446	pyridine nucleotide-disulphide oxidoreductase
M892_24015	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M892_24020	COG1845	cytochrome c oxidase, subunit III
M892_24025	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M892_24030	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M892_24035	COG1028	Short-chain dehydrogenase reductase Sdr
M892_24045	COG1024	Enoyl-CoA hydratase
M892_24050	COG1024	Enoyl-CoA hydratase
M892_24065	COG0183	Belongs to the thiolase family
M892_24075	COG1960	acyl-CoA dehydrogenase activity
M892_24080	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M892_24085	COG1024	Enoyl-CoA hydratase
M892_24125	COG3278	Belongs to the heme-copper respiratory oxidase family
M892_24160	COG2433	Pfam Transposase IS66
M892_24165	COG0243	molybdopterin cofactor binding
M892_24170	COG3005	denitrification pathway
M892_24180	COG1119	ATPase activity
M892_24185	COG2200	EAL domain
M892_24200	COG0513	Belongs to the DEAD box helicase family
M892_24205	COG5002	protein histidine kinase activity
M892_24205	COG3447	MASE1 domain protein
M892_24205	COG5001	Diguanylate cyclase
M892_24210	COG3385	transposase activity
M892_24215	COG0523	cobalamin synthesis protein
M892_24240	COG0454	-acetyltransferase
M892_24255	COG3530	Putative quorum-sensing-regulated virulence factor
M892_24285	COG3186	Phenylalanine-4-hydroxylase
M892_24290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M892_24295	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M892_24320	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
M892_24325	COG1454	alcohol dehydrogenase
M892_24330	COG2133	pyrroloquinoline quinone binding
M892_24335	COG1619	proteins homologs of microcin C7 resistance protein MccF
M892_24345	COG0783	Belongs to the Dps family
M892_24360	COG1136	(ABC) transporter
M892_24360	COG0577	efflux transmembrane transporter activity
M892_24380	COG2199	diguanylate cyclase activity
M892_24390	COG3036	rescue of stalled ribosome
M892_24395	COG1278	Cold shock
M892_24425	COG0545	Peptidyl-prolyl cis-trans isomerase
M892_24430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M892_24440	COG0840	transmembrane signaling receptor activity
M892_24450	COG2195	Cleaves the N-terminal amino acid of tripeptides
M892_24465	COG2197	response regulator
M892_24470	COG3850	Histidine kinase
M892_24480	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M892_24500	COG3005	denitrification pathway
M892_24510	COG2433	Pfam Transposase IS66
M892_24535	COG0183	Belongs to the thiolase family
M892_24545	COG1280	lysine exporter protein (LysE YggA)
M892_24555	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M892_24560	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M892_24600	COG3385	transposase activity
M892_24640	COG0673	inositol 2-dehydrogenase activity
M892_24665	COG0583	DNA-binding transcription factor activity
M892_24675	COG1522	sequence-specific DNA binding
M892_24680	COG0531	amino acid
M892_24685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M892_24695	COG2205	protein histidine kinase activity
M892_24700	COG0745	RESPONSE REGULATOR receiver
M892_24730	COG1566	PFAM secretion protein HlyD family protein
M892_24735	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M892_24740	COG2239	Acts as a magnesium transporter
M892_24745	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M892_24750	COG0402	S-adenosylhomocysteine deaminase activity
M892_24765	COG1418	mRNA catabolic process
M892_24790	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M892_24795	COG3385	transposase activity
M892_24815	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M892_24830	COG4221	oxidoreductase activity
M892_24845	COG3335	DDE superfamily endonuclease
M892_24875	COG0745	RESPONSE REGULATOR receiver
M892_24880	COG2205	protein histidine kinase activity
M892_24890	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M892_24895	COG2194	sulfuric ester hydrolase activity
M892_24900	COG0673	inositol 2-dehydrogenase activity
M892_24905	COG4977	sequence-specific DNA binding
M892_24940	COG0583	DNA-binding transcription factor activity
M892_24945	COG2249	NAD(P)H dehydrogenase (quinone) activity
M892_24960	COG0583	DNA-binding transcription factor activity
M892_24990	COG2433	Pfam Transposase IS66
M892_25045	COG0366	Alpha amylase catalytic
M892_25050	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M892_25055	COG0784	Response regulator, receiver
M892_25055	COG0835	chemotaxis
M892_25070	COG0748	coenzyme F420 binding
M892_25075	COG3721	Heme iron utilization protein
M892_25085	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
M892_25090	COG0811	peptide transport
M892_25095	COG0848	biopolymer transport protein
M892_25105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M892_25110	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M892_25150	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M892_25165	COG0401	homolog of Blt101
M892_25175	COG2354	Protein conserved in bacteria
M892_25220	COG1175	transmembrane transport
M892_25235	COG3842	ATPase activity
M892_25240	COG3335	DDE superfamily endonuclease
M892_25255	COG2433	Pfam Transposase IS66
M892_25265	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M892_25320	COG1309	transcriptional regulator
M892_25325	COG2130	NADP-dependent
M892_25335	COG0753	catalase activity
M892_25340	COG2084	Dehydrogenase
M892_25350	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M892_25355	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M892_25365	COG2207	Transcriptional regulator
M892_25370	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M892_25370	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M892_25370	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M892_25400	COG3385	transposase activity
M892_25405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M892_25410	COG1301	dicarboxylic acid transport
M892_25420	COG1252	NADH dehydrogenase
M892_25430	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
M892_25435	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M892_25450	COG2885	chlorophyll binding
M892_25450	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M892_25470	COG1028	Short-chain dehydrogenase reductase Sdr
M892_25475	COG4191	Histidine kinase
M892_25480	COG2204	response regulator
M892_25505	COG2197	response regulator
M892_25520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M892_25525	COG0714	Associated with various cellular activities
M892_25545	COG2304	oxidoreductase activity
M892_25565	COG0581	inorganic phosphate transmembrane transporter activity
M892_25570	COG0573	inorganic phosphate transmembrane transporter activity
M892_25575	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M892_25615	COG1770	oligopeptidase
M892_25625	COG0513	Belongs to the DEAD box helicase family
M892_25635	COG1388	LysM domain
M892_25635	COG1376	ErfK ybiS ycfS ynhG family protein
M892_25640	COG0415	Belongs to the DNA photolyase family
M892_25645	COG0789	Transcriptional regulator
M892_25650	COG3272	Protein of unknown function (DUF1722)
M892_25655	COG0813	purine-nucleoside phosphorylase activity
M892_25670	COG3706	GGDEF domain
M892_25690	COG1566	PFAM secretion protein HlyD family protein
M892_25700	COG1122	ATPase activity
M892_25725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M892_25745	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M892_25755	COG1067	ATP-dependent peptidase activity
M892_25765	COG4172	Belongs to the ABC transporter superfamily
M892_25775	COG1505	serine-type exopeptidase activity
M892_25785	COG1304	FMN binding
M892_25790	COG1304	FMN binding
M892_25800	COG0668	transmembrane transport
M892_25805	COG3385	transposase activity
M892_25815	COG3335	DDE superfamily endonuclease
M892_25830	COG3335	DDE superfamily endonuclease
M892_25835	COG3335	DDE superfamily endonuclease
M892_25840	COG3706	GGDEF domain
M892_25850	COG3335	DDE superfamily endonuclease
M892_25855	COG4372	Transposase
M892_25885	COG2433	Pfam Transposase IS66
M892_25915	COG1063	alcohol dehydrogenase
M892_25940	COG3547	Transposase (IS116 IS110 IS902 family)
M892_26080	COG4695	Portal protein
M892_26175	COG4974	Belongs to the 'phage' integrase family
M892_26180	COG1063	alcohol dehydrogenase
M892_26200	COG3385	transposase activity
M892_26215	COG0745	RESPONSE REGULATOR receiver
M892_26240	COG0346	lactoylglutathione lyase activity
M892_26245	COG0346	lactoylglutathione lyase activity
M892_26290	COG2200	EAL domain
M892_26310	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M892_26325	COG2204	response regulator
M892_26350	COG1987	bacterial-type flagellum assembly
M892_26360	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M892_26375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M892_26390	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M892_26395	COG1516	flagellar protein fliS
M892_26410	COG1580	Controls the rotational direction of flagella during chemotaxis
M892_26415	COG1191	sigma factor activity
M892_26420	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M892_26425	COG1360	Flagellar Motor Protein
M892_26435	COG0384	phenazine biosynthesis protein PhzF
M892_26490	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M892_26500	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M892_26505	COG1473	amidohydrolase
M892_26510	COG3335	DDE superfamily endonuclease
M892_26525	COG1522	sequence-specific DNA binding
M892_26560	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M892_26575	COG1706	bacterial-type flagellum-dependent cell motility
M892_26580	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M892_26585	COG4786	Flagellar basal body rod
M892_26590	COG4787	bacterial-type flagellum-dependent cell motility
M892_26595	COG1749	Flagellar hook protein flgE
M892_26600	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M892_26605	COG1558	bacterial-type flagellum-dependent cell motility
M892_26610	COG1815	bacterial-type flagellum-dependent cell motility
M892_26630	COG1388	LysM domain
M892_26630	COG0741	lytic transglycosylase activity
M892_26655	COG1760	l-serine dehydratase
M892_26685	COG0583	DNA-binding transcription factor activity
M892_26695	COG2866	Carboxypeptidase
M892_26700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M892_26705	COG3385	transposase activity
M892_26715	COG2990	Protein conserved in bacteria
M892_26740	COG3842	ATPase activity
M892_26750	COG1840	ABC-type Fe3 transport system, periplasmic component
M892_26780	COG3240	lipase activity
M892_26785	COG3385	transposase activity
M892_26790	COG3335	DDE superfamily endonuclease
M892_26800	COG3339	Conserved Protein
M892_26805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M892_26815	COG3366	ferrous iron transmembrane transporter activity
M892_26835	COG0366	Alpha amylase catalytic
M892_26850	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M892_26855	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M892_26860	COG1640	4-alpha-glucanotransferase
M892_26865	COG0058	SHG alpha-glucan phosphorylase activity
M892_26890	COG1999	signal sequence binding
M892_26900	COG1263	PTS System
M892_26900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M892_26910	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
M892_26930	COG0531	amino acid
M892_26935	COG1982	Orn Lys Arg decarboxylase major
M892_26955	COG2356	endonuclease I
M892_26965	COG0366	Alpha amylase catalytic
M892_26990	COG1760	l-serine dehydratase
M892_27010	COG1609	Transcriptional regulator
M892_27030	COG0739	heme binding
M892_27045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M892_27060	COG3344	reverse transcriptase
M892_27075	COG3121	Chaperone
M892_27080	COG3188	usher protein
M892_27140	COG2249	NAD(P)H dehydrogenase (quinone) activity
M892_27155	COG1335	isochorismatase
M892_27160	COG1136	(ABC) transporter
M892_27200	COG1764	response to oxidative stress
M892_27205	COG1846	Transcriptional regulator
M892_27210	COG0450	alkyl hydroperoxide reductase
M892_27215	COG3634	alkyl hydroperoxide reductase activity
M892_27230	COG2610	gluconate transmembrane transporter activity
M892_27235	COG3622	Belongs to the hyi family
M892_27240	COG0235	Class ii aldolase
M892_27245	COG3395	kinase activity
M892_27250	COG2084	Dehydrogenase
M892_27255	COG1349	DNA-binding transcription factor activity
M892_27275	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
M892_27285	COG1522	sequence-specific DNA binding
M892_27335	COG5464	transposase or invertase
M892_27405	COG3335	DDE superfamily endonuclease
M892_27450	COG1132	(ABC) transporter
M892_27655	COG3335	DDE superfamily endonuclease
M892_27665	COG0655	NAD(P)H dehydrogenase (quinone) activity
M892_27695	COG1444	tRNA N-acetyltransferase activity
M892_27700	COG3385	transposase activity
M892_27730	COG0444	Belongs to the ABC transporter superfamily
M892_27740	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
M892_27740	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M892_27745	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M892_27745	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
M892_27770	COG0772	Belongs to the SEDS family
M892_27785	COG0583	DNA-binding transcription factor activity
M892_27815	COG3275	phosphorelay sensor kinase activity
M892_27820	COG3279	Response regulator of the LytR AlgR family
M892_27825	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M892_27845	COG0786	glutamate:sodium symporter activity
M892_27850	COG1028	Short-chain dehydrogenase reductase Sdr
M892_27890	COG1131	(ABC) transporter
M892_27895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M892_27900	COG0786	glutamate:sodium symporter activity
M892_28275	COG2003	Belongs to the UPF0758 family
M892_28330	COG2433	Pfam Transposase IS66
M892_28380	COG3547	Transposase (IS116 IS110 IS902 family)
M892_28395	COG3547	Transposase (IS116 IS110 IS902 family)
M892_28435	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M892_28465	COG3504	Conjugal transfer protein
M892_28470	COG3736	Type IV secretory pathway, component VirB8
M892_28495	COG3451	type IV secretory pathway VirB4
M892_28540	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
M892_28560	COG1192	Involved in chromosome partitioning
M892_28595	COG2433	Pfam Transposase IS66
M892_28675	COG3344	reverse transcriptase
M892_28710	COG1192	Involved in chromosome partitioning
M892_28720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M892_28725	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M892_28735	COG3344	reverse transcriptase
M892_28745	COG3335	DDE superfamily endonuclease