locus-tag	class	description
CAY59_00005	COG2081	HI0933 family
CAY59_00035	COG2081	HI0933 family
CAY59_00045	COG1528	Iron-storage protein
CAY59_00050	COG0589	response to stress
CAY59_00055	COG0697	spore germination
CAY59_00070	COG5002	protein histidine kinase activity
CAY59_00070	COG5001	Diguanylate cyclase
CAY59_00075	COG1522	sequence-specific DNA binding
CAY59_00090	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CAY59_00100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CAY59_00105	COG0800	Aldolase
CAY59_00110	COG2610	gluconate transmembrane transporter activity
CAY59_00115	COG3265	gluconokinase activity
CAY59_00120	COG0129	dihydroxy-acid dehydratase activity
CAY59_00130	COG2076	Multidrug Resistance protein
CAY59_00135	COG0583	DNA-binding transcription factor activity
CAY59_00140	COG1609	Transcriptional regulator
CAY59_00145	COG0515	serine threonine protein kinase
CAY59_00175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAY59_00190	COG4172	Belongs to the ABC transporter superfamily
CAY59_00240	COG1309	transcriptional regulator
CAY59_00245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAY59_00250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAY59_00255	COG2960	long-chain fatty acid transporting porin activity
CAY59_00265	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CAY59_00270	COG0583	DNA-binding transcription factor activity
CAY59_00320	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CAY59_00325	COG1739	Uncharacterized protein family UPF0029
CAY59_00335	COG0183	Belongs to the thiolase family
CAY59_00340	COG0604	alcohol dehydrogenase
CAY59_00355	COG0425	Belongs to the sulfur carrier protein TusA family
CAY59_00365	COG2119	membrane
CAY59_00385	COG2205	protein histidine kinase activity
CAY59_00440	COG4964	Belongs to the GSP D family
CAY59_00460	COG3977	Valine--pyruvate aminotransferase
CAY59_00465	COG0071	Belongs to the small heat shock protein (HSP20) family
CAY59_00470	COG0187	DNA topoisomerase II activity
CAY59_00480	COG0592	DNA-directed DNA polymerase activity
CAY59_00505	COG1126	abc transporter atp-binding protein
CAY59_00520	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CAY59_00535	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CAY59_00555	COG1475	DNA binding
CAY59_00560	COG3312	ion transport
CAY59_00590	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CAY59_00600	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CAY59_00610	COG0765	amino acid transport
CAY59_00615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAY59_00620	COG2814	Major facilitator Superfamily
CAY59_00625	COG0583	DNA-binding transcription factor activity
CAY59_00630	COG3706	GGDEF domain
CAY59_00640	COG0129	dihydroxy-acid dehydratase activity
CAY59_00645	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CAY59_00650	COG3978	acetolactate synthase activity
CAY59_00660	COG0606	chelatase, subunit chli
CAY59_00685	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CAY59_00690	COG0732	type I restriction modification DNA specificity domain
CAY59_00695	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CAY59_00725	COG0606	chelatase, subunit chli
CAY59_00730	COG2199	diguanylate cyclase activity
CAY59_00740	COG0204	Acyl-transferase
CAY59_00745	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CAY59_00750	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CAY59_00760	COG3084	Protein conserved in bacteria
CAY59_00765	COG4326	sporulation control protein
CAY59_00770	COG1272	protein, Hemolysin III
CAY59_00780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CAY59_00785	COG0569	domain protein
CAY59_00790	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CAY59_00790	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CAY59_00800	COG0242	peptide deformylase activity
CAY59_00810	COG0758	DNA mediated transformation
CAY59_00820	COG0551	DNA topoisomerase type I activity
CAY59_00825	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CAY59_00830	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CAY59_00855	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CAY59_00900	COG2132	Multicopper oxidase
CAY59_00920	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CAY59_00925	COG2104	thiamine diphosphate biosynthetic process
CAY59_00940	COG0006	proline dipeptidase activity
CAY59_00940	COG0006	proline dipeptidase activity
CAY59_00950	COG2814	Major facilitator Superfamily
CAY59_00970	COG3220	belongs to the UPF0276 family
CAY59_00980	COG0210	DNA helicase
CAY59_00990	COG0405	Gamma-glutamyltransferase
CAY59_00995	COG1280	lysine exporter protein (LysE YggA)
CAY59_01015	COG2962	Rard protein
CAY59_01020	COG0514	ATP-dependent DNA helicase (RecQ)
CAY59_01030	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CAY59_01045	COG3118	belongs to the thioredoxin family
CAY59_01050	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CAY59_01060	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CAY59_01065	COG0633	Ferredoxin
CAY59_01105	COG3071	HemY protein
CAY59_01110	COG2959	enzyme of heme biosynthesis
CAY59_01115	COG1587	Uroporphyrinogen-III synthase
CAY59_01125	COG3072	Adenylate cyclase
CAY59_01130	COG1965	Belongs to the frataxin family
CAY59_01140	COG0019	diaminopimelate decarboxylase activity
CAY59_01160	COG1011	Hydrolase
CAY59_01165	COG2199	diguanylate cyclase activity
CAY59_01165	COG3287	FIST C domain
CAY59_01165	COG2200	EAL domain
CAY59_01185	COG0561	phosphatase activity
CAY59_01190	COG2267	carboxylic ester hydrolase activity
CAY59_01195	COG1280	lysine exporter protein (LysE YggA)
CAY59_01200	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CAY59_01205	COG0640	Transcriptional regulator
CAY59_01210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CAY59_01265	COG2095	MarC family integral membrane protein
CAY59_01275	COG0742	ribosomal rna small subunit methyltransferase
CAY59_01280	COG0552	protein localization to endoplasmic reticulum
CAY59_01285	COG2884	Cell division ATP-binding protein ftsE
CAY59_01290	COG2177	Part of the ABC transporter FtsEX involved in
CAY59_01310	COG0705	Rhomboid family
CAY59_01315	COG1580	Controls the rotational direction of flagella during chemotaxis
CAY59_01320	COG3161	chorismate lyase activity
CAY59_01330	COG2937	Belongs to the GPAT DAPAT family
CAY59_01350	COG0534	Mate efflux family protein
CAY59_01465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CAY59_01475	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CAY59_01520	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CAY59_01525	COG0250	Participates in transcription elongation, termination and antitermination
CAY59_01540	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CAY59_01560	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
CAY59_01565	COG2816	NAD+ diphosphatase activity
CAY59_01585	COG1573	uracil-dna glycosylase
CAY59_01595	COG3068	Protein conserved in bacteria
CAY59_01600	COG1253	flavin adenine dinucleotide binding
CAY59_01615	COG0151	Belongs to the GarS family
CAY59_01625	COG0789	Transcriptional regulator
CAY59_01630	COG3710	Transcriptional regulator
CAY59_01640	COG0531	amino acid
CAY59_01645	COG1982	Orn Lys Arg decarboxylase major
CAY59_01690	COG3706	GGDEF domain
CAY59_01695	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CAY59_01700	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CAY59_01710	COG0439	Biotin carboxylase
CAY59_01715	COG0511	ligase activity, forming carbon-carbon bonds
CAY59_01720	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CAY59_01725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CAY59_01740	COG2814	Major facilitator Superfamily
CAY59_01745	COG0784	Response regulator, receiver
CAY59_01745	COG2205	protein histidine kinase activity
CAY59_01745	COG2198	Histidine kinase
CAY59_01765	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CAY59_01775	COG2095	MarC family integral membrane protein
CAY59_01790	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CAY59_01795	COG1027	Aspartate ammonia-lyase
CAY59_01800	COG3030	protein affecting phage T7 exclusion by the F plasmid
CAY59_01805	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CAY59_01815	COG2205	protein histidine kinase activity
CAY59_01820	COG0745	RESPONSE REGULATOR receiver
CAY59_01840	COG0534	Mate efflux family protein
CAY59_01845	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CAY59_01865	COG1509	lysine 2,3-aminomutase activity
CAY59_01895	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CAY59_01900	COG1053	succinate dehydrogenase
CAY59_01925	COG4942	peptidase
CAY59_01930	COG1045	serine acetyltransferase
CAY59_01945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CAY59_01950	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CAY59_02000	COG0471	metal ion transport
CAY59_02010	COG1162	GTPase activity
CAY59_02085	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CAY59_02090	COG0802	atpase or kinase
CAY59_02095	COG0860	N-Acetylmuramoyl-L-alanine amidase
CAY59_02100	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CAY59_02115	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CAY59_02120	COG0330	HflC and HflK could
CAY59_02125	COG0330	HflC and HflK could
CAY59_02130	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CAY59_02135	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CAY59_02140	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CAY59_02145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CAY59_02145	COG1017	nitric oxide dioxygenase activity
CAY59_02155	COG0557	exoribonuclease II activity
CAY59_02160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CAY59_02165	COG0546	phosphoglycolate phosphatase activity
CAY59_02185	COG0512	Glutamine amidotransferase of anthranilate synthase
CAY59_02190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CAY59_02210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAY59_02215	COG3954	Phosphoribulokinase
CAY59_02225	COG0429	hydrolase of the alpha beta-hydrolase fold
CAY59_02235	COG0488	(ABC) transporter
CAY59_02240	COG2249	NAD(P)H dehydrogenase (quinone) activity
CAY59_02255	COG1047	Peptidyl-prolyl cis-trans
CAY59_02260	COG1446	asparaginase
CAY59_02275	COG0545	Peptidyl-prolyl cis-trans isomerase
CAY59_02280	COG2964	Protein conserved in bacteria
CAY59_02285	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CAY59_02290	COG2923	Belongs to the DsrF TusC family
CAY59_02295	COG2168	tRNA wobble position uridine thiolation
CAY59_02310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CAY59_02320	COG2906	2 iron, 2 sulfur cluster binding
CAY59_02330	COG0281	malic enzyme
CAY59_02340	COG0626	cystathionine gamma-synthase activity
CAY59_02345	COG0527	aspartate kinase activity
CAY59_02345	COG0460	homoserine dehydrogenase
CAY59_02350	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CAY59_02360	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CAY59_02370	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CAY59_02385	COG0165	Argininosuccinate lyase
CAY59_02385	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CAY59_02395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CAY59_02400	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CAY59_02400	COG0678	peroxiredoxin activity
CAY59_02410	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CAY59_02455	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CAY59_02460	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CAY59_02470	COG2965	DNA replication, synthesis of RNA primer
CAY59_02490	COG0305	Participates in initiation and elongation during chromosome replication
CAY59_02495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CAY59_02505	COG0432	Pfam Uncharacterised protein family UPF0047
CAY59_02520	COG0735	belongs to the Fur family
CAY59_02525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CAY59_02545	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CAY59_02620	COG0527	aspartate kinase activity
CAY59_02630	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CAY59_02640	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CAY59_02655	COG0629	single-stranded DNA binding
CAY59_02660	COG2200	EAL domain
CAY59_02660	COG2199	diguanylate cyclase activity
CAY59_02685	COG3267	Type II secretory pathway component ExeA
CAY59_02685	COG3409	Peptidoglycan-binding domain 1 protein
CAY59_02695	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CAY59_02700	COG1459	type II secretion system
CAY59_02745	COG1077	Cell shape determining protein MreB Mrl
CAY59_02750	COG1792	Involved in formation and maintenance of cell shape
CAY59_02755	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CAY59_02760	COG0424	maF-like protein
CAY59_02770	COG3164	Protein of unknown function
CAY59_02775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CAY59_02780	COG0312	modulator of DNA gyrase
CAY59_02785	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CAY59_02800	COG0564	pseudouridine synthase activity
CAY59_02805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CAY59_02815	COG0312	modulator of DNA gyrase
CAY59_02820	COG2239	Acts as a magnesium transporter
CAY59_02825	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAY59_02835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAY59_02840	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CAY59_02855	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CAY59_02865	COG0517	IMP dehydrogenase activity
CAY59_02865	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CAY59_02875	COG1127	ABC transporter
CAY59_02880	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CAY59_02885	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CAY59_02890	COG2854	intermembrane phospholipid transfer
CAY59_02900	COG5007	Belongs to the BolA IbaG family
CAY59_02910	COG0204	Acyl-transferase
CAY59_02915	COG0251	oxidation-reduction process
CAY59_02955	COG0456	acetyltransferase
CAY59_02965	COG0525	valine-tRNA ligase activity
CAY59_02970	COG2927	DNA polymerase III (CHI subunit)
CAY59_02980	COG0795	lipopolysaccharide-transporting ATPase activity
CAY59_02985	COG0795	lipopolysaccharide-transporting ATPase activity
CAY59_02995	COG1028	Short-chain dehydrogenase reductase Sdr
CAY59_03005	COG0726	polysaccharide deacetylase
CAY59_03010	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CAY59_03020	COG1447	Phosphotransferase system cellobiose-specific component IIA
CAY59_03040	COG3437	response regulator, receiver
CAY59_03090	COG1012	belongs to the aldehyde dehydrogenase family
CAY59_03190	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CAY59_03195	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CAY59_03210	COG0762	integral membrane protein
CAY59_03215	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CAY59_03220	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CAY59_03235	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CAY59_03240	COG1678	Uncharacterized ACR, COG1678
CAY59_03245	COG0189	ligase activity
CAY59_03250	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CAY59_03255	COG2356	endonuclease I
CAY59_03275	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CAY59_03295	COG0191	fructose-bisphosphate aldolase activity
CAY59_03300	COG0668	transmembrane transport
CAY59_03315	COG0583	DNA-binding transcription factor activity
CAY59_03320	COG2968	Membrane
CAY59_03325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CAY59_03335	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CAY59_03345	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CAY59_03355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAY59_03360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAY59_03380	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CAY59_03390	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CAY59_03395	COG1595	DNA-templated transcription, initiation
CAY59_03410	COG3086	response to oxidative stress
CAY59_03420	COG0681	Belongs to the peptidase S26 family
CAY59_03430	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CAY59_03435	COG1381	Involved in DNA repair and RecF pathway recombination
CAY59_03440	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CAY59_03465	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CAY59_03470	COG3956	TIGRFAM MazG family protein
CAY59_03480	COG0148	phosphopyruvate hydratase activity
CAY59_03495	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CAY59_03525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CAY59_03535	COG1546	Belongs to the CinA family
CAY59_03540	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CAY59_03555	COG0527	aspartate kinase activity
CAY59_03620	COG5016	pyruvate
CAY59_03620	COG0511	ligase activity, forming carbon-carbon bonds
CAY59_03625	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CAY59_03635	COG1238	metal cluster binding
CAY59_03640	COG0612	Peptidase, M16
CAY59_03660	COG4536	flavin adenine dinucleotide binding
CAY59_03665	COG4137	Cytochrome C assembly protein
CAY59_03670	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CAY59_03700	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CAY59_03705	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CAY59_03710	COG0237	dephospho-CoA kinase activity
CAY59_03725	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CAY59_03750	COG2186	Transcriptional regulator
CAY59_03755	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CAY59_03760	COG0508	dehydrogenase complex catalyzes the overall conversion of
CAY59_03765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CAY59_03780	COG0288	reversible hydration of carbon dioxide
CAY59_03785	COG0659	secondary active sulfate transmembrane transporter activity
CAY59_03790	COG1131	(ABC) transporter
CAY59_03795	COG0842	Transport permease protein
CAY59_03800	COG1560	Kdo2-lipid A biosynthetic process
CAY59_03815	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CAY59_03825	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CAY59_03830	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CAY59_03840	COG1643	Atp-dependent helicase
CAY59_03845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CAY59_03850	COG1752	Esterase of the alpha-beta hydrolase superfamily
CAY59_03855	COG1049	propionate catabolic process, 2-methylcitrate cycle
CAY59_03870	COG0004	ammonium transporteR
CAY59_03875	COG1840	ABC-type Fe3 transport system, periplasmic component
CAY59_03885	COG3842	ATPase activity
CAY59_03890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CAY59_03905	COG2971	BadF BadG BcrA BcrD
CAY59_03915	COG4608	Belongs to the ABC transporter superfamily
CAY59_03920	COG0444	Belongs to the ABC transporter superfamily
CAY59_03925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAY59_03935	COG0747	negative chemotaxis
CAY59_03955	COG0628	permease
CAY59_03980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAY59_03985	COG0739	heme binding
CAY59_03990	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CAY59_04005	COG2027	D-alanyl-D-alanine carboxypeptidase
CAY59_04010	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CAY59_04015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CAY59_04020	COG1534	Rna-binding protein
CAY59_04030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CAY59_04035	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CAY59_04050	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CAY59_04070	COG0195	Participates in both transcription termination and antitermination
CAY59_04090	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CAY59_04110	COG0534	Mate efflux family protein
CAY59_04135	COG3153	acetyltransferase
CAY59_04155	COG3706	GGDEF domain
CAY59_04165	COG0084	hydrolase, TatD family'
CAY59_04170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CAY59_04180	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CAY59_04190	COG0813	purine-nucleoside phosphorylase activity
CAY59_04200	COG0560	Phosphoserine phosphatase
CAY59_04210	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CAY59_04215	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CAY59_04245	COG1022	Amp-dependent synthetase and ligase
CAY59_04250	COG2169	Transcriptional regulator
CAY59_04270	COG4964	Belongs to the GSP D family
CAY59_04330	COG0583	DNA-binding transcription factor activity
CAY59_04335	COG3408	Glycogen debranching enzyme
CAY59_04335	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CAY59_04345	COG0531	amino acid
CAY59_04350	COG2731	YhcH YjgK YiaL family protein
CAY59_04355	COG3250	beta-galactosidase activity
CAY59_04360	COG1609	Transcriptional regulator
CAY59_04365	COG0768	penicillin binding
CAY59_04370	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CAY59_04375	COG1085	galactose-1-phosphate uridylyltransferase
CAY59_04385	COG2017	converts alpha-aldose to the beta-anomer
CAY59_04390	COG1609	Transcriptional regulator
CAY59_04395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CAY59_04395	COG1263	PTS System
CAY59_04405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CAY59_04430	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CAY59_04435	COG1349	DNA-binding transcription factor activity
CAY59_04450	COG2271	Major facilitator Superfamily
CAY59_04455	COG0584	glycerophosphoryl diester phosphodiesterase
CAY59_04470	COG2171	N-acyltransferase activity
CAY59_04485	COG3141	response to X-ray
CAY59_04505	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CAY59_04510	COG1074	ATP-dependent DNA helicase activity
CAY59_04515	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CAY59_04535	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CAY59_04535	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CAY59_04550	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CAY59_04555	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CAY59_04560	COG2166	iron-sulfur cluster assembly
CAY59_04565	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CAY59_04570	COG0693	protein deglycase activity
CAY59_04575	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CAY59_04580	COG3248	Nucleoside-binding outer membrane protein
CAY59_04595	COG1595	DNA-templated transcription, initiation
CAY59_04625	COG0271	Belongs to the BolA IbaG family
CAY59_04660	COG1477	protein flavinylation
CAY59_04670	COG0745	RESPONSE REGULATOR receiver
CAY59_04670	COG3706	GGDEF domain
CAY59_04680	COG0514	ATP-dependent DNA helicase (RecQ)
CAY59_04685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CAY59_04700	COG0733	neurotransmitter:sodium symporter activity
CAY59_04725	COG1720	tRNA m6t6A37 methyltransferase activity
CAY59_04740	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CAY59_04775	COG3098	single-species biofilm formation
CAY59_04780	COG0564	pseudouridine synthase activity
CAY59_04795	COG0024	Methionine aminopeptidase
CAY59_04820	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CAY59_04825	COG0575	Belongs to the CDS family
CAY59_04835	COG0750	zinc metalloprotease
CAY59_04845	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CAY59_04850	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CAY59_04875	COG0587	DNA-directed DNA polymerase activity
CAY59_04895	COG0347	Belongs to the P(II) protein family
CAY59_04910	COG0741	lytic transglycosylase activity
CAY59_04910	COG1388	LysM domain
CAY59_04920	COG2226	methyltransferase
CAY59_04930	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CAY59_04960	COG1960	acyl-CoA dehydrogenase activity
CAY59_04965	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CAY59_04970	COG0121	glutamine amidotransferase
CAY59_04975	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CAY59_04980	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CAY59_04985	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CAY59_04990	COG2233	PERMEase
CAY59_05010	COG1393	Belongs to the ArsC family
CAY59_05015	COG4783	chaperone-mediated protein folding
CAY59_05030	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CAY59_05035	COG2716	regulation of RNA biosynthetic process
CAY59_05040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAY59_05065	COG1393	Belongs to the ArsC family
CAY59_05095	COG2837	iron assimilation
CAY59_05100	COG2169	Transcriptional regulator
CAY59_05105	COG1486	melibiose metabolic process
CAY59_05110	COG2211	Major facilitator Superfamily
CAY59_05120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CAY59_05130	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CAY59_05135	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CAY59_05140	COG1334	flagellar protein FlaG
CAY59_05145	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CAY59_05155	COG1516	flagellar protein fliS
CAY59_05165	COG4191	Histidine kinase
CAY59_05170	COG2204	response regulator
CAY59_05175	COG1677	Flagellar hook-basal body complex protein FliE
CAY59_05185	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CAY59_05240	COG1987	bacterial-type flagellum assembly
CAY59_05245	COG1684	flagellar biosynthetic protein fliR
CAY59_05265	COG0455	bacterial-type flagellum organization
CAY59_05280	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CAY59_05285	COG2198	Histidine kinase
CAY59_05285	COG0643	Histidine kinase
CAY59_05290	COG2201	protein-glutamate methylesterase activity
CAY59_05295	COG1192	Involved in chromosome partitioning
CAY59_05305	COG0835	chemotaxis
CAY59_05315	COG4133	protoheme IX ABC transporter activity
CAY59_05320	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CAY59_05325	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CAY59_05340	COG1138	Cytochrome C-type biogenesis protein
CAY59_05345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CAY59_05355	COG4235	cytochrome complex assembly
CAY59_05355	COG3088	subunit of a heme lyase
CAY59_05360	COG2853	Lipoprotein
CAY59_05365	COG2067	long-chain fatty acid transport protein
CAY59_05390	COG0183	Belongs to the thiolase family
CAY59_05410	COG2062	phosphohistidine phosphatase, SixA
CAY59_05420	COG2890	protein-(glutamine-N5) methyltransferase activity
CAY59_05430	COG2860	membrane
CAY59_05435	COG3101	peptidyl-lysine hydroxylation
CAY59_05460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CAY59_05470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CAY59_05500	COG0285	dihydrofolate synthase activity
CAY59_05505	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CAY59_05510	COG1286	toxin biosynthetic process
CAY59_05515	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CAY59_05520	COG0583	DNA-binding transcription factor activity
CAY59_05530	COG2832	Protein of unknown function (DUF454)
CAY59_05540	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CAY59_05550	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CAY59_05555	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CAY59_05560	COG0814	amino acid
CAY59_05565	COG0251	oxidation-reduction process
CAY59_05575	COG2964	Protein conserved in bacteria
CAY59_05585	COG2983	Belongs to the UPF0260 family
CAY59_05590	COG2261	transglycosylase associated protein
CAY59_05595	COG2985	domain, Protein
CAY59_05600	COG0076	glutamate decarboxylase activity
CAY59_05605	COG0668	transmembrane transport
CAY59_05615	COG0346	lactoylglutathione lyase activity
CAY59_05625	COG1785	Belongs to the alkaline phosphatase family
CAY59_05645	COG2226	methyltransferase
CAY59_05665	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CAY59_05680	COG3139	Protein of unknown function (DUF1315)
CAY59_05685	COG0252	asparaginase activity
CAY59_05690	COG0616	signal peptide processing
CAY59_05695	COG0446	pyridine nucleotide-disulphide oxidoreductase
CAY59_05695	COG1902	pentaerythritol trinitrate reductase activity
CAY59_05700	COG0778	Nitroreductase
CAY59_05705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CAY59_05720	COG0123	including yeast histone deacetylase and acetoin utilization protein
CAY59_05730	COG4269	membrane
CAY59_05745	COG3083	sulfuric ester hydrolase activity
CAY59_05770	COG1757	Na H antiporter
CAY59_05775	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CAY59_05780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAY59_05785	COG2095	MarC family integral membrane protein
CAY59_05790	COG1454	alcohol dehydrogenase
CAY59_05790	COG1012	belongs to the aldehyde dehydrogenase family
CAY59_05795	COG1028	Short-chain dehydrogenase reductase Sdr
CAY59_05810	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CAY59_05820	COG2056	Na+-H+ antiporter family
CAY59_05830	COG2885	chlorophyll binding
CAY59_05840	COG0346	lactoylglutathione lyase activity
CAY59_05845	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CAY59_05850	COG4660	Part of a membrane complex involved in electron transport
CAY59_05855	COG4659	FMN binding
CAY59_05860	COG4658	electron transport chain
CAY59_05875	COG4657	Part of a membrane complex involved in electron transport
CAY59_05880	COG1882	Formate acetyltransferase
CAY59_05890	COG0745	RESPONSE REGULATOR receiver
CAY59_05925	COG0556	nucleotide-excision repair
CAY59_05940	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CAY59_05945	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CAY59_05950	COG0521	Mo-molybdopterin cofactor biosynthetic process
CAY59_05960	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CAY59_05965	COG0314	molybdopterin synthase activity
CAY59_05975	COG0601	transmembrane transport
CAY59_05980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAY59_05985	COG0444	Belongs to the ABC transporter superfamily
CAY59_05995	COG0435	Glutathione S-transferase
CAY59_06000	COG3174	membrane
CAY59_06005	COG0857	belongs to the CobB CobQ family
CAY59_06005	COG0280	phosphate acetyltransferase
CAY59_06025	COG4120	Belongs to the binding-protein-dependent transport system permease family
CAY59_06030	COG1122	ATPase activity
CAY59_06035	COG0366	Alpha amylase catalytic
CAY59_06040	COG3706	GGDEF domain
CAY59_06040	COG0745	RESPONSE REGULATOR receiver
CAY59_06045	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CAY59_06050	COG0653	protein targeting
CAY59_06055	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CAY59_06065	COG2186	Transcriptional regulator
CAY59_06095	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CAY59_06100	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CAY59_06105	COG0659	secondary active sulfate transmembrane transporter activity
CAY59_06115	COG1530	ribonuclease E activity
CAY59_06120	COG0564	pseudouridine synthase activity
CAY59_06125	COG0424	maF-like protein
CAY59_06130	COG1399	metal-binding, possibly nucleic acid-binding protein
CAY59_06145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CAY59_06175	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CAY59_06190	COG0084	hydrolase, TatD family'
CAY59_06195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CAY59_06195	COG1263	PTS System
CAY59_06205	COG0733	neurotransmitter:sodium symporter activity
CAY59_06215	COG4667	esterase of the alpha-beta hydrolase superfamily
CAY59_06240	COG2272	Belongs to the type-B carboxylesterase lipase family
CAY59_06250	COG3710	Transcriptional regulator
CAY59_06265	COG1940	carbohydrate kinase activity
CAY59_06270	COG0835	chemotaxis
CAY59_06270	COG0784	Response regulator, receiver
CAY59_06290	COG1028	Short-chain dehydrogenase reductase Sdr
CAY59_06295	COG0616	signal peptide processing
CAY59_06315	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CAY59_06320	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CAY59_06350	COG3009	Protein conserved in bacteria
CAY59_06355	COG3008	intermembrane lipid transfer
CAY59_06355	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CAY59_06360	COG2995	paraquat-inducible protein a
CAY59_06365	COG1609	Transcriptional regulator
CAY59_06380	COG4580	involved in the transport of maltose and maltodextrins
CAY59_06395	COG2211	Major facilitator Superfamily
CAY59_06400	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CAY59_06420	COG3118	belongs to the thioredoxin family
CAY59_06430	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CAY59_06445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CAY59_06465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAY59_06475	COG0577	efflux transmembrane transporter activity
CAY59_06485	COG1136	(ABC) transporter
CAY59_06485	COG0577	efflux transmembrane transporter activity
CAY59_06500	COG2176	DNA-directed DNA polymerase activity
CAY59_06590	COG5002	protein histidine kinase activity
CAY59_06590	COG3850	Histidine kinase
CAY59_06595	COG0745	RESPONSE REGULATOR receiver
CAY59_06600	COG0463	Glycosyl transferase, family 2
CAY59_06605	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CAY59_06615	COG0840	transmembrane signaling receptor activity
CAY59_06630	COG2175	clavaminate synthase activity
CAY59_06635	COG2964	Protein conserved in bacteria
CAY59_06640	COG0251	oxidation-reduction process
CAY59_06650	COG0446	pyridine nucleotide-disulphide oxidoreductase
CAY59_06675	COG1032	radical SAM domain protein
CAY59_06680	COG1716	ATPase activity
CAY59_06680	COG5001	Diguanylate cyclase
CAY59_06710	COG2350	Protein conserved in bacteria
CAY59_06715	COG1607	acyl-coa hydrolase
CAY59_06740	COG1301	dicarboxylic acid transport
CAY59_06745	COG0159	tryptophan synthase activity
CAY59_06755	COG0135	phosphoribosylanthranilate isomerase activity
CAY59_06755	COG0134	indole-3-glycerol-phosphate synthase activity
CAY59_06765	COG0512	Glutamine amidotransferase of anthranilate synthase
CAY59_06770	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CAY59_06780	COG0613	PHP domain protein
CAY59_06785	COG0009	L-threonylcarbamoyladenylate synthase
CAY59_06795	COG1187	pseudouridine synthase activity
CAY59_06815	COG0417	DNA replication proofreading
CAY59_06820	COG2197	response regulator
CAY59_06825	COG0322	excinuclease ABC activity
CAY59_06870	COG0019	diaminopimelate decarboxylase activity
CAY59_06885	COG1058	Belongs to the CinA family
CAY59_06885	COG1546	Belongs to the CinA family
CAY59_06895	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CAY59_06900	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CAY59_06925	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CAY59_06935	COG0437	4 iron, 4 sulfur cluster binding
CAY59_06940	COG3301	Polysulphide reductase, NrfD
CAY59_06945	COG1138	Cytochrome C-type biogenesis protein
CAY59_06955	COG3088	subunit of a heme lyase
CAY59_06955	COG4235	cytochrome complex assembly
CAY59_06990	COG2989	Protein conserved in bacteria
CAY59_06995	COG3108	Peptidase M15
CAY59_07000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAY59_07015	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CAY59_07040	COG1846	Transcriptional regulator
CAY59_07045	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CAY59_07050	COG0840	transmembrane signaling receptor activity
CAY59_07070	COG1448	Aminotransferase
CAY59_07090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CAY59_07115	COG0720	synthase
CAY59_07120	COG2197	response regulator
CAY59_07135	COG1760	l-serine dehydratase
CAY59_07140	COG0814	amino acid
CAY59_07155	COG2205	protein histidine kinase activity
CAY59_07155	COG0784	Response regulator, receiver
CAY59_07160	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CAY59_07175	COG3106	COG3106 Predicted ATPase
CAY59_07190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CAY59_07410	COG0494	nUDIX hydrolase
CAY59_07860	COG4221	oxidoreductase activity
CAY59_07905	COG0456	acetyltransferase
CAY59_07910	COG0471	metal ion transport
CAY59_07915	COG4191	Histidine kinase
CAY59_07915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAY59_07935	COG1280	lysine exporter protein (LysE YggA)
CAY59_07940	COG1328	CTP reductase activity
CAY59_07945	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CAY59_07955	COG0861	Integral membrane protein TerC family
CAY59_07965	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CAY59_07970	COG4221	oxidoreductase activity
CAY59_07980	COG0814	amino acid
CAY59_08000	COG1132	(ABC) transporter
CAY59_08005	COG1132	(ABC) transporter
CAY59_08015	COG0583	DNA-binding transcription factor activity
CAY59_08040	COG0443	Heat shock 70 kDa protein
CAY59_08045	COG0443	Heat shock 70 kDa protein
CAY59_08055	COG3706	GGDEF domain
CAY59_08085	COG3227	Zinc metalloprotease (Elastase)
CAY59_08105	COG3842	ATPase activity
CAY59_08110	COG3459	Glycosyltransferase 36 associated
CAY59_08120	COG1653	transport
CAY59_08130	COG0395	ABC-type sugar transport system, permease component
CAY59_08145	COG0243	molybdopterin cofactor binding
CAY59_08150	COG0437	4 iron, 4 sulfur cluster binding
CAY59_08155	COG3302	dmso reductase anchor subunit
CAY59_08170	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CAY59_08175	COG1643	Atp-dependent helicase
CAY59_08200	COG3063	Type IV pilus biogenesis stability protein PilW
CAY59_08230	COG0531	amino acid
CAY59_08235	COG1280	lysine exporter protein (LysE YggA)
CAY59_08240	COG1560	Kdo2-lipid A biosynthetic process
CAY59_08260	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CAY59_08265	COG1280	lysine exporter protein (LysE YggA)
CAY59_08300	COG1115	amino acid carrier protein
CAY59_08320	COG1368	sulfuric ester hydrolase activity
CAY59_08325	COG0215	cysteine-tRNA ligase activity
CAY59_08330	COG0534	Mate efflux family protein
CAY59_08335	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CAY59_08345	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CAY59_08350	COG0456	acetyltransferase
CAY59_08355	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CAY59_08360	COG0662	Cupin 2, conserved barrel domain protein
CAY59_08365	COG0527	aspartate kinase activity
CAY59_08380	COG1858	cytochrome C peroxidase
CAY59_08385	COG1404	Belongs to the peptidase S8 family
CAY59_08390	COG3227	Zinc metalloprotease (Elastase)
CAY59_08405	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CAY59_08410	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CAY59_08415	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CAY59_08440	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CAY59_08445	COG0667	Aldo Keto reductase
CAY59_08460	COG0583	DNA-binding transcription factor activity
CAY59_08465	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CAY59_08470	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CAY59_08475	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CAY59_08480	COG0679	Auxin Efflux Carrier
CAY59_08520	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CAY59_08540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CAY59_08545	COG1999	signal sequence binding
CAY59_08560	COG3005	denitrification pathway
CAY59_08575	COG0583	DNA-binding transcription factor activity
CAY59_08590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAY59_08605	COG3290	protein histidine kinase activity
CAY59_08610	COG4565	transcriptional regulatory protein
CAY59_08615	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CAY59_08620	COG0363	glucosamine-6-phosphate deaminase activity
CAY59_08625	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CAY59_08655	COG3284	Transcriptional regulator
CAY59_08660	COG1012	belongs to the aldehyde dehydrogenase family
CAY59_08670	COG0730	response to heat
CAY59_08715	COG0784	Response regulator, receiver
CAY59_08715	COG3437	response regulator, receiver
CAY59_08825	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CAY59_08830	COG0372	Belongs to the citrate synthase family
CAY59_08840	COG2828	Protein conserved in bacteria
CAY59_08855	COG3119	arylsulfatase activity
CAY59_08875	COG0561	phosphatase activity
CAY59_08880	COG0602	queuosine metabolic process
CAY59_08890	COG3706	GGDEF domain
CAY59_08955	COG0840	transmembrane signaling receptor activity
CAY59_08960	COG1254	Belongs to the acylphosphatase family
CAY59_08965	COG2920	part of a sulfur-relay system
CAY59_08975	COG0670	Belongs to the BI1 family
CAY59_08980	COG1126	abc transporter atp-binding protein
CAY59_08985	COG0765	amino acid transport
CAY59_08990	COG4597	amino acid ABC transporter
CAY59_08995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAY59_09010	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CAY59_09035	COG3008	intermembrane lipid transfer
CAY59_09040	COG2995	paraquat-inducible protein a
CAY59_09045	COG1132	(ABC) transporter
CAY59_09050	COG1956	GAF domain-containing protein
CAY59_09055	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
CAY59_09070	COG0308	aminopeptidase N
CAY59_09080	COG2902	Dehydrogenase
CAY59_09125	COG1067	ATP-dependent peptidase activity
CAY59_09155	COG2205	protein histidine kinase activity
CAY59_09155	COG0784	Response regulator, receiver
CAY59_09170	COG3278	Belongs to the heme-copper respiratory oxidase family
CAY59_09185	COG2010	Cytochrome c
CAY59_09195	COG2217	Heavy metal translocating P-type atpase
CAY59_09210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAY59_09215	COG0589	response to stress
CAY59_09240	COG3842	ATPase activity
CAY59_09245	COG1176	ABC-type spermidine putrescine transport system, permease component I
CAY59_09250	COG1177	transmembrane transport
CAY59_09255	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CAY59_09260	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CAY59_09265	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CAY59_09285	COG0437	4 iron, 4 sulfur cluster binding
CAY59_09290	COG0243	molybdopterin cofactor binding
CAY59_09290	COG3383	formate dehydrogenase (NAD+) activity
CAY59_09300	COG3381	protein complex oligomerization
CAY59_09320	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CAY59_09330	COG0584	glycerophosphoryl diester phosphodiesterase
CAY59_09335	COG0488	(ABC) transporter
CAY59_09350	COG4191	Histidine kinase
CAY59_09355	COG2204	response regulator
CAY59_09365	COG4662	Binding-protein-dependent transport system inner membrane component
CAY59_09370	COG3842	ATPase activity
CAY59_09380	COG0303	'Molybdopterin
CAY59_09390	COG1940	carbohydrate kinase activity
CAY59_09445	COG0840	transmembrane signaling receptor activity
CAY59_09450	COG0791	NLP P60 protein
CAY59_09460	COG3706	GGDEF domain
CAY59_09465	COG2201	protein-glutamate methylesterase activity
CAY59_09485	COG0534	Mate efflux family protein
CAY59_09495	COG1793	dna ligase
CAY59_09505	COG2885	chlorophyll binding
CAY59_09525	COG2204	response regulator
CAY59_09530	COG0438	transferase activity, transferring glycosyl groups
CAY59_09535	COG0438	transferase activity, transferring glycosyl groups
CAY59_09565	COG0438	transferase activity, transferring glycosyl groups
CAY59_09570	COG1215	transferase activity, transferring glycosyl groups
CAY59_09575	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CAY59_09585	COG3064	Membrane
CAY59_09610	COG5001	Diguanylate cyclase
CAY59_09610	COG3300	MHYT domain
CAY59_09635	COG0110	maltose O-acetyltransferase activity
CAY59_09660	COG1846	Transcriptional regulator
CAY59_09670	COG1482	cell wall glycoprotein biosynthetic process
CAY59_09685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CAY59_09705	COG0383	alpha-mannosidase activity
CAY59_09740	COG3247	response to pH
CAY59_09745	COG0668	transmembrane transport
CAY59_09755	COG1404	Belongs to the peptidase S8 family
CAY59_09765	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CAY59_09800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAY59_09815	COG0786	glutamate:sodium symporter activity
CAY59_09840	COG0625	glutathione transferase activity
CAY59_09850	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CAY59_09865	COG2195	Cleaves the N-terminal amino acid of tripeptides
CAY59_09900	COG0813	purine-nucleoside phosphorylase activity
CAY59_09915	COG0745	RESPONSE REGULATOR receiver
CAY59_09915	COG3706	GGDEF domain
CAY59_09925	COG1451	nucleotide metabolic process
CAY59_09935	COG5492	domain, Protein
CAY59_09935	COG4932	domain protein
CAY59_09950	COG2201	protein-glutamate methylesterase activity
CAY59_10020	COG4968	Prepilin-type N-terminal cleavage methylation domain
CAY59_10045	COG0583	DNA-binding transcription factor activity
CAY59_10075	COG4139	cobalamin transport
CAY59_10090	COG2062	phosphohistidine phosphatase, SixA
CAY59_10100	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CAY59_10110	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CAY59_10120	COG0702	epimerase
CAY59_10135	COG2925	Exonuclease
CAY59_10145	COG1346	cytolysis
CAY59_10195	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAY59_10205	COG4607	ABC-type enterochelin transport system periplasmic component
CAY59_10210	COG4774	siderophore transport
CAY59_10215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CAY59_10220	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CAY59_10230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CAY59_10250	COG1535	isochorismatase
CAY59_10250	COG3433	isochorismatase activity
CAY59_10255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CAY59_10255	COG0072	phenylalanine-tRNA ligase activity
CAY59_10310	COG0251	oxidation-reduction process
CAY59_10355	COG2188	Transcriptional regulator
CAY59_10365	COG0010	Belongs to the arginase family
CAY59_10375	COG2986	histidine ammonia-lyase
CAY59_10420	COG0247	lactate metabolic process
CAY59_10420	COG0277	FAD linked oxidase domain protein
CAY59_10480	COG1643	Atp-dependent helicase
CAY59_10490	COG2949	membrane
CAY59_10495	COG0471	metal ion transport
CAY59_10500	COG3706	GGDEF domain
CAY59_10530	COG0492	ferredoxin-NADP+ reductase activity
CAY59_10535	COG4988	ABC transporter
CAY59_10540	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CAY59_10550	COG2610	gluconate transmembrane transporter activity
CAY59_10555	COG0583	DNA-binding transcription factor activity
CAY59_10560	COG2200	EAL domain
CAY59_10595	COG5001	Diguanylate cyclase
CAY59_10610	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CAY59_10620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAY59_10620	COG4191	Histidine kinase
CAY59_10635	COG3070	regulator of competence-specific genes
CAY59_10645	COG2431	L-lysine efflux transmembrane transporter activity
CAY59_10655	COG0076	glutamate decarboxylase activity
CAY59_10660	COG1737	Transcriptional regulator
CAY59_10670	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CAY59_10680	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CAY59_10710	COG4181	ATPase activity
CAY59_10715	COG0534	Mate efflux family protein
CAY59_10720	COG0702	epimerase
CAY59_10725	COG4667	esterase of the alpha-beta hydrolase superfamily
CAY59_10735	COG2814	Major facilitator Superfamily
CAY59_10740	COG1187	pseudouridine synthase activity
CAY59_10745	COG1061	Type III restriction enzyme res subunit
CAY59_10750	COG3706	GGDEF domain
CAY59_10760	COG0745	RESPONSE REGULATOR receiver
CAY59_10765	COG2205	protein histidine kinase activity
CAY59_10810	COG3313	Fe-S protein
CAY59_10820	COG0659	secondary active sulfate transmembrane transporter activity
CAY59_10845	COG0493	'glutamate synthase
CAY59_10855	COG0398	Pfam SNARE associated Golgi protein
CAY59_10860	COG4134	Bacterial extracellular solute-binding protein
CAY59_10865	COG4135	transport system, permease component
CAY59_10870	COG4136	ATPase activity
CAY59_10875	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CAY59_10890	COG3604	Transcriptional regulator
CAY59_10895	COG1151	hydroxylamine reductase activity
CAY59_10900	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CAY59_10910	COG0564	pseudouridine synthase activity
CAY59_10920	COG0733	neurotransmitter:sodium symporter activity
CAY59_10930	COG0626	cystathionine gamma-synthase activity
CAY59_10935	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CAY59_10955	COG2818	Glycosylase
CAY59_10975	COG1983	PspC domain protein
CAY59_10985	COG1842	Phage shock protein A
CAY59_10990	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CAY59_11000	COG4168	peptide transport system, permease
CAY59_11005	COG4171	peptide transport system, permease
CAY59_11015	COG4172	Belongs to the ABC transporter superfamily
CAY59_11025	COG1227	inorganic diphosphatase activity
CAY59_11045	COG3005	denitrification pathway
CAY59_11050	COG4459	periplasmic nitrate reductase
CAY59_11055	COG0390	transport system, permease component
CAY59_11060	COG2116	formate transmembrane transporter activity
CAY59_11085	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CAY59_11090	COG1435	thymidine kinase activity
CAY59_11095	COG0215	cysteine-tRNA ligase activity
CAY59_11100	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CAY59_11105	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CAY59_11110	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CAY59_11115	COG3012	SEC-C Motif Domain Protein
CAY59_11120	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CAY59_11120	COG0140	phosphoribosyl-ATP diphosphatase activity
CAY59_11125	COG0107	imidazoleglycerol-phosphate synthase activity
CAY59_11130	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CAY59_11135	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CAY59_11140	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CAY59_11140	COG0131	Imidazoleglycerol-phosphate dehydratase
CAY59_11150	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CAY59_11165	COG1757	Na H antiporter
CAY59_11175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAY59_11185	COG0482	sulfurtransferase activity
CAY59_11195	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CAY59_11215	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CAY59_11230	COG0300	oxidoreductase activity
CAY59_11270	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CAY59_11290	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CAY59_11310	COG0686	Belongs to the AlaDH PNT family
CAY59_11320	COG0583	DNA-binding transcription factor activity
CAY59_11345	COG0402	S-adenosylhomocysteine deaminase activity
CAY59_11370	COG3568	Endonuclease Exonuclease Phosphatase
CAY59_11390	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CAY59_11405	COG1288	antiporter activity
CAY59_11415	COG2186	Transcriptional regulator
CAY59_11425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAY59_11430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAY59_11460	COG0747	negative chemotaxis
CAY59_11465	COG4608	Belongs to the ABC transporter superfamily
CAY59_11470	COG0444	Belongs to the ABC transporter superfamily
CAY59_11480	COG2824	Alkylphosphonate utilization operon protein PhnA
CAY59_11500	COG3119	arylsulfatase activity
CAY59_11540	COG0457	Tetratricopeptide repeat
CAY59_11605	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CAY59_11610	COG4790	Type iii secretion
CAY59_11615	COG4794	Type iii secretion
CAY59_11620	COG4791	protein targeting
CAY59_11625	COG4792	protein secretion
CAY59_11640	COG3177	Filamentation induced by cAMP protein fic
CAY59_11670	COG4669	(LipO)protein
CAY59_11765	COG2205	protein histidine kinase activity
CAY59_11765	COG0784	Response regulator, receiver
CAY59_11775	COG0754	glutathionylspermidine amidase activity
CAY59_11785	COG3766	membrane
CAY59_11800	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CAY59_11810	COG0823	Involved in the tonB-independent uptake of proteins
CAY59_11825	COG0811	peptide transport
CAY59_11840	COG4890	Cyd operon protein YbgT
CAY59_11845	COG1294	oxidase, subunit
CAY59_11850	COG1271	oxidase subunit
CAY59_11860	COG0840	transmembrane signaling receptor activity
CAY59_11875	COG1801	Protein of unknown function DUF72
CAY59_11890	COG4067	protein conserved in archaea
CAY59_11890	COG0189	ligase activity
CAY59_11910	COG0318	PFAM AMP-dependent synthetase and ligase
CAY59_11925	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CAY59_11930	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CAY59_11940	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CAY59_11945	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CAY59_11950	COG0745	RESPONSE REGULATOR receiver
CAY59_11965	COG3070	regulator of competence-specific genes
CAY59_11985	COG0297	glycogen (starch) synthase activity
CAY59_11990	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CAY59_11995	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CAY59_12025	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CAY59_12030	COG0542	response to heat
CAY59_12040	COG1278	Cold shock
CAY59_12050	COG1187	pseudouridine synthase activity
CAY59_12055	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
CAY59_12070	COG0730	response to heat
CAY59_12075	COG3923	Primosomal replication protein n
CAY59_12085	COG0708	Exodeoxyribonuclease III
CAY59_12095	COG4215	(ABC) transporter
CAY59_12120	COG1882	Formate acetyltransferase
CAY59_12130	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CAY59_12145	COG2766	serine protein kinase
CAY59_12150	COG2718	Belongs to the UPF0229 family
CAY59_12155	COG2719	SpoVR family
CAY59_12175	COG1132	(ABC) transporter
CAY59_12180	COG2333	competence protein COMEC
CAY59_12180	COG0658	competence protein
CAY59_12190	COG4591	ABC-type transport system involved in lipoprotein release permease component
CAY59_12195	COG1136	(ABC) transporter
CAY59_12200	COG4591	ABC-type transport system involved in lipoprotein release permease component
CAY59_12210	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CAY59_12225	COG1252	NADH dehydrogenase
CAY59_12255	COG0537	adenosine 5'-monophosphoramidase activity
CAY59_12275	COG2217	Heavy metal translocating P-type atpase
CAY59_12285	COG0517	IMP dehydrogenase activity
CAY59_12285	COG0516	GMP reductase activity
CAY59_12290	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CAY59_12295	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CAY59_12300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CAY59_12310	COG3706	GGDEF domain
CAY59_12325	COG3126	Type III secretion system lipoprotein chaperone (YscW)
CAY59_12330	COG1946	Acyl-CoA thioesterase
CAY59_12335	COG1522	sequence-specific DNA binding
CAY59_12360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAY59_12415	COG2855	membrane
CAY59_12435	COG0583	DNA-binding transcription factor activity
CAY59_12440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CAY59_12440	COG2190	(PTS) system
CAY59_12440	COG1263	PTS System
CAY59_12450	COG1441	menaquinone biosynthetic process
CAY59_12455	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CAY59_12460	COG0596	Alpha beta hydrolase
CAY59_12470	COG1169	isochorismate synthase
CAY59_12475	COG0436	Aminotransferase
CAY59_12480	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CAY59_12500	COG1555	photosystem II stabilization
CAY59_12505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CAY59_12510	COG0776	regulation of translation
CAY59_12515	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CAY59_12550	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CAY59_12555	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CAY59_12560	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CAY59_12580	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CAY59_12585	COG0569	domain protein
CAY59_12590	COG0513	Belongs to the DEAD box helicase family
CAY59_12595	COG1253	flavin adenine dinucleotide binding
CAY59_12615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CAY59_12615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CAY59_12620	COG1535	isochorismatase
CAY59_12620	COG3433	isochorismatase activity
CAY59_12625	COG1021	2,3-dihydroxybenzoate-AMP ligase
CAY59_12630	COG1169	isochorismate synthase
CAY59_12640	COG1028	Short-chain dehydrogenase reductase Sdr
CAY59_12670	COG2852	Protein conserved in bacteria
CAY59_12675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CAY59_12685	COG2951	lytic endotransglycosylase activity
CAY59_12700	COG2894	cell division
CAY59_12705	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CAY59_12710	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CAY59_12715	COG0318	PFAM AMP-dependent synthetase and ligase
CAY59_12720	COG2267	carboxylic ester hydrolase activity
CAY59_12725	COG3065	identical protein binding
CAY59_12735	COG1214	PFAM Peptidase M22, glycoprotease
CAY59_12740	COG1199	ATP-dependent helicase activity
CAY59_12765	COG3102	Protein conserved in bacteria
CAY59_12795	COG1918	ferrous iron import across plasma membrane
CAY59_12800	COG4977	sequence-specific DNA binding
CAY59_12805	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CAY59_12810	COG1121	(ABC) transporter
CAY59_12815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CAY59_12830	COG0508	dehydrogenase complex catalyzes the overall conversion of
CAY59_12835	COG0567	Dehydrogenase, E1 component
CAY59_12845	COG1053	succinate dehydrogenase
CAY59_12850	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CAY59_12855	COG2009	succinate dehydrogenase
CAY59_12865	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CAY59_12880	COG0033	Phosphoglucomutase
CAY59_12890	COG0596	Alpha beta hydrolase
CAY59_12910	COG0735	belongs to the Fur family
CAY59_12920	COG2190	(PTS) system
CAY59_12920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CAY59_12920	COG1263	PTS System
CAY59_12925	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CAY59_12930	COG1940	carbohydrate kinase activity
CAY59_12930	COG1846	Transcriptional regulator
CAY59_12935	COG4651	solute:proton antiporter activity
CAY59_12935	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CAY59_12940	COG0367	asparagine synthase
CAY59_12950	COG3104	oligopeptide transport
CAY59_12955	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CAY59_12970	COG3710	Transcriptional regulator
CAY59_12990	COG0622	Phosphoesterase
CAY59_13020	COG1090	epimerase
CAY59_13025	COG0300	oxidoreductase activity
CAY59_13035	COG3118	belongs to the thioredoxin family
CAY59_13040	COG0457	Tetratricopeptide repeat
CAY59_13040	COG3118	belongs to the thioredoxin family
CAY59_13045	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CAY59_13050	COG1215	transferase activity, transferring glycosyl groups
CAY59_13055	COG1215	transferase activity, transferring glycosyl groups
CAY59_13060	COG1192	Involved in chromosome partitioning
CAY59_13075	COG2194	sulfuric ester hydrolase activity
CAY59_13080	COG0330	HflC and HflK could
CAY59_13115	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
CAY59_13120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CAY59_13130	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAY59_13135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CAY59_13140	COG2190	(PTS) system
CAY59_13145	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CAY59_13150	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CAY59_13155	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CAY59_13170	COG3951	Flagellar rod assembly protein muramidase FlgJ
CAY59_13170	COG1705	Flagellar rod assembly protein muramidase FlgJ
CAY59_13175	COG1706	bacterial-type flagellum-dependent cell motility
CAY59_13180	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CAY59_13185	COG4786	Flagellar basal body rod
CAY59_13190	COG4787	bacterial-type flagellum-dependent cell motility
CAY59_13195	COG1749	Flagellar hook protein flgE
CAY59_13200	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CAY59_13205	COG1558	bacterial-type flagellum-dependent cell motility
CAY59_13210	COG1815	bacterial-type flagellum-dependent cell motility
CAY59_13215	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CAY59_13220	COG0784	Response regulator, receiver
CAY59_13220	COG0835	chemotaxis
CAY59_13285	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
CAY59_13295	COG2217	Heavy metal translocating P-type atpase
CAY59_13295	COG2608	mercury ion transmembrane transporter activity
CAY59_13330	COG2840	Smr protein MutS2
CAY59_13335	COG1187	pseudouridine synthase activity
CAY59_13340	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CAY59_13345	COG0737	Belongs to the 5'-nucleotidase family
CAY59_13355	COG2912	Transglutaminase-like superfamily
CAY59_13360	COG3094	Invasion gene expression up-regulator, SirB
CAY59_13365	COG2890	protein-(glutamine-N5) methyltransferase activity
CAY59_13390	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CAY59_13515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAY59_13525	COG1702	phosphate starvation-inducible protein PhoH
CAY59_13535	COG4535	Mg2 and Co2 transporter CorC
CAY59_13540	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CAY59_13545	COG2888	peptidyl-tyrosine sulfation
CAY59_13555	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
CAY59_13560	COG1466	dna polymerase III delta subunit
CAY59_13565	COG0799	negative regulation of ribosome biogenesis
CAY59_13575	COG0768	penicillin binding
CAY59_13580	COG0772	Belongs to the SEDS family
CAY59_13585	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CAY59_13590	COG1686	Belongs to the peptidase S11 family
CAY59_13610	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CAY59_13615	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CAY59_13620	COG0366	Alpha amylase catalytic
CAY59_13625	COG1263	PTS System
CAY59_13625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CAY59_13635	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CAY59_13640	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CAY59_13645	COG2011	ABC-type metal ion transport system permease component
CAY59_13650	COG1464	Belongs to the NlpA lipoprotein family
CAY59_13660	COG0737	Belongs to the 5'-nucleotidase family
CAY59_13665	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
CAY59_13685	COG0745	RESPONSE REGULATOR receiver
CAY59_13685	COG3706	GGDEF domain
CAY59_13690	COG1611	Belongs to the LOG family
CAY59_13705	COG2363	Small membrane protein
CAY59_13715	COG0583	DNA-binding transcription factor activity
CAY59_13730	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CAY59_13740	COG0142	geranyltranstransferase activity
CAY59_13750	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CAY59_13755	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CAY59_13780	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CAY59_13780	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CAY59_13785	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CAY59_13790	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CAY59_13815	COG2252	PERMEase
CAY59_13820	COG2195	Cleaves the N-terminal amino acid of tripeptides
CAY59_13855	COG0590	tRNA wobble adenosine to inosine editing
CAY59_13865	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CAY59_13910	COG1301	dicarboxylic acid transport
CAY59_13925	COG0497	DNA recombination
CAY59_13930	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CAY59_13935	COG2914	Belongs to the UPF0125 (RnfH) family
CAY59_13940	COG2867	negative regulation of translational initiation
CAY59_13955	COG0582	viral genome integration into host DNA
CAY59_13980	COG0732	type I restriction modification DNA specificity domain
CAY59_13985	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CAY59_13995	COG1401	restriction endodeoxyribonuclease activity
CAY59_14075	COG0583	DNA-binding transcription factor activity
CAY59_14080	COG1289	transmembrane transporter activity
CAY59_14100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CAY59_14105	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CAY59_14125	COG0583	DNA-binding transcription factor activity
CAY59_14135	COG1115	amino acid carrier protein
CAY59_14140	COG1584	GPR1 FUN34 yaaH family protein
CAY59_14150	COG1757	Na H antiporter
CAY59_14160	COG0517	IMP dehydrogenase activity
CAY59_14160	COG0516	GMP reductase activity
CAY59_14175	COG2199	diguanylate cyclase activity
CAY59_14175	COG2203	Gaf domain
CAY59_14190	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CAY59_14195	COG2976	Protein conserved in bacteria
CAY59_14230	COG2975	iron-sulfur cluster assembly
CAY59_14235	COG0633	Ferredoxin
CAY59_14250	COG0316	Belongs to the HesB IscA family
CAY59_14255	COG0822	iron-sulfur transferase activity
CAY59_14270	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CAY59_14275	COG0483	inositol monophosphate 1-phosphatase activity
CAY59_14280	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CAY59_14285	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CAY59_14290	COG1862	Preprotein translocase
CAY59_14315	COG0517	IMP dehydrogenase activity
CAY59_14325	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CAY59_14330	COG0583	DNA-binding transcription factor activity
CAY59_14335	COG0450	alkyl hydroperoxide reductase
CAY59_14360	COG0704	Plays a role in the regulation of phosphate uptake
CAY59_14365	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CAY59_14370	COG0581	inorganic phosphate transmembrane transporter activity
CAY59_14375	COG0573	inorganic phosphate transmembrane transporter activity
CAY59_14380	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CAY59_14385	COG0248	Ppx GppA phosphatase
CAY59_14400	COG0745	RESPONSE REGULATOR receiver
CAY59_14420	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CAY59_14475	COG0542	response to heat
CAY59_14485	COG0564	pseudouridine synthase activity
CAY59_14490	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CAY59_14495	COG0741	lytic transglycosylase activity
CAY59_14500	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CAY59_14505	COG0077	Prephenate dehydratase
CAY59_14505	COG1605	Chorismate mutase
CAY59_14510	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CAY59_14525	COG0488	(ABC) transporter
CAY59_14535	COG0739	heme binding
CAY59_14540	COG1605	Chorismate mutase
CAY59_14540	COG0287	Prephenate dehydrogenase
CAY59_14545	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CAY59_14550	COG1472	Belongs to the glycosyl hydrolase 3 family
CAY59_14555	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CAY59_14575	COG1966	Carbon starvation protein
CAY59_14580	COG3275	phosphorelay sensor kinase activity
CAY59_14585	COG3279	Response regulator of the LytR AlgR family
CAY59_14590	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CAY59_14595	COG1047	Peptidyl-prolyl cis-trans
CAY59_14610	COG0196	riboflavin kinase activity
CAY59_14615	COG0728	peptidoglycan biosynthetic process
CAY59_14620	COG0268	Binds directly to 16S ribosomal RNA
CAY59_14625	COG0640	Transcriptional regulator
CAY59_14630	COG0583	DNA-binding transcription factor activity
CAY59_14635	COG1283	sodium-dependent phosphate transmembrane transporter activity
CAY59_14655	COG0730	response to heat
CAY59_14680	COG0667	Aldo Keto reductase
CAY59_14705	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CAY59_14710	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CAY59_14720	COG0716	FMN binding
CAY59_14735	COG0513	Belongs to the DEAD box helicase family
CAY59_14745	COG3022	response to hydroperoxide
CAY59_14750	COG1115	amino acid carrier protein
CAY59_14785	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CAY59_14790	COG0083	homoserine kinase activity
CAY59_14805	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CAY59_14815	COG0745	RESPONSE REGULATOR receiver
CAY59_14835	COG2203	Gaf domain
CAY59_14835	COG3706	GGDEF domain
CAY59_14835	COG4251	negative regulation of phosphorylation
CAY59_14835	COG5001	Diguanylate cyclase
CAY59_14840	COG1242	4 iron, 4 sulfur cluster binding
CAY59_14855	COG0070	glutamate synthase
CAY59_14855	COG0067	glutamate synthase
CAY59_14855	COG0069	glutamate synthase activity
CAY59_14860	COG0493	'glutamate synthase
CAY59_14885	COG2860	membrane
CAY59_14890	COG0583	DNA-binding transcription factor activity
CAY59_14895	COG0730	response to heat
CAY59_14915	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CAY59_14920	COG0505	Belongs to the CarA family
CAY59_14930	COG0494	nUDIX hydrolase
CAY59_14950	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CAY59_14955	COG0849	cell division
CAY59_14960	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CAY59_14975	COG0772	Belongs to the SEDS family
CAY59_14990	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CAY59_14995	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CAY59_15000	COG0768	penicillin binding
CAY59_15005	COG3116	cell division
CAY59_15020	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CAY59_15035	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CAY59_15040	COG2823	Periplasmic or secreted lipoprotein
CAY59_15045	COG2969	positive regulation of protein catabolic process
CAY59_15050	COG0625	glutathione transferase activity
CAY59_15055	COG2857	Cytochrome c1
CAY59_15060	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CAY59_15065	COG0723	plastoquinol--plastocyanin reductase activity
CAY59_15080	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CAY59_15085	COG3105	Protein conserved in bacteria
CAY59_15090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAY59_15095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAY59_15100	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CAY59_15105	COG0187	DNA topoisomerase II activity
CAY59_15110	COG3150	esterase
CAY59_15120	COG3151	Protein conserved in bacteria
CAY59_15125	COG0494	nUDIX hydrolase
CAY59_15130	COG1538	Outer membrane efflux protein
CAY59_15150	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CAY59_15155	COG3025	triphosphatase activity
CAY59_15160	COG1392	Phosphate transport regulator
CAY59_15165	COG0306	phosphate transporter
CAY59_15170	COG4991	sh3 domain protein
CAY59_15185	COG3267	Type II secretory pathway component ExeA
CAY59_15185	COG3409	Peptidoglycan-binding domain 1 protein
CAY59_15200	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CAY59_15205	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CAY59_15215	COG0596	Alpha beta hydrolase
CAY59_15220	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CAY59_15225	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CAY59_15230	COG1610	YqeY-like protein
CAY59_15240	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CAY59_15275	COG2213	PTS system mannitol-specific
CAY59_15275	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAY59_15285	COG3722	fumarate hydratase activity
CAY59_15290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CAY59_15315	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CAY59_15320	COG1349	DNA-binding transcription factor activity
CAY59_15325	COG0469	pyruvate kinase activity
CAY59_15335	COG3706	GGDEF domain
CAY59_15340	COG0440	acetolactate synthase activity
CAY59_15345	COG0028	Belongs to the TPP enzyme family
CAY59_15350	COG1022	Amp-dependent synthetase and ligase
CAY59_15355	COG0583	DNA-binding transcription factor activity
CAY59_15380	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CAY59_15385	COG0473	3-isopropylmalate dehydrogenase activity
CAY59_15405	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CAY59_15410	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CAY59_15415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CAY59_15420	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CAY59_15440	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CAY59_15445	COG3610	response to peptide
CAY59_15450	COG2966	Psort location CytoplasmicMembrane, score
CAY59_15465	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CAY59_15470	COG0142	geranyltranstransferase activity
CAY59_15505	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CAY59_15510	COG1178	ABC-type Fe3 transport system permease component
CAY59_15515	COG4143	(ABC) transporter
CAY59_15520	COG0163	prenyltransferase activity
CAY59_15525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CAY59_15535	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CAY59_15550	COG2105	PFAM AIG2 family protein
CAY59_15560	COG0729	surface antigen
CAY59_15565	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CAY59_15575	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CAY59_15590	COG1136	(ABC) transporter
CAY59_15610	COG0529	Catalyzes the synthesis of activated sulfate
CAY59_15615	COG3273	potassium ion transport
CAY59_15615	COG0471	metal ion transport
CAY59_15630	COG1648	precorrin-2 dehydrogenase activity
CAY59_15630	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CAY59_15635	COG0737	Belongs to the 5'-nucleotidase family
CAY59_15645	COG0513	Belongs to the DEAD box helicase family
CAY59_15650	COG2153	protein acetylation
CAY59_15665	COG0545	Peptidyl-prolyl cis-trans isomerase
CAY59_15675	COG0203	ribosomal protein L17
CAY59_15680	COG0202	RNA polymerase activity
CAY59_15690	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CAY59_15695	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CAY59_15705	COG0201	protein transport
CAY59_15715	COG1841	ribosomal large subunit assembly
CAY59_15800	COG0088	Forms part of the polypeptide exit tunnel
CAY59_15820	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CAY59_15825	COG1609	Transcriptional regulator
CAY59_15845	COG1575	Belongs to the MenA family. Type 1 subfamily
CAY59_15850	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CAY59_15860	COG1494	fructose-1,6-bisphosphatase
CAY59_15885	COG0149	triose-phosphate isomerase activity
CAY59_15910	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CAY59_15915	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CAY59_15940	COG1086	Polysaccharide biosynthesis protein
CAY59_15965	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CAY59_15970	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CAY59_15975	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CAY59_15980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CAY59_15985	COG1482	cell wall glycoprotein biosynthetic process
CAY59_16020	COG1215	transferase activity, transferring glycosyl groups
CAY59_16070	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CAY59_16080	COG1560	Kdo2-lipid A biosynthetic process
CAY59_16085	COG0859	PFAM glycosyl transferase family 9
CAY59_16090	COG1519	Transferase
CAY59_16095	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CAY59_16100	COG0110	maltose O-acetyltransferase activity
CAY59_16105	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CAY59_16110	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CAY59_16125	COG3642	lipopolysaccharide core region biosynthetic process
CAY59_16130	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CAY59_16135	COG0438	transferase activity, transferring glycosyl groups
CAY59_16140	COG0859	PFAM glycosyl transferase family 9
CAY59_16190	COG0840	transmembrane signaling receptor activity
CAY59_16195	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CAY59_16205	COG1560	Kdo2-lipid A biosynthetic process
CAY59_16220	COG1561	YicC-like family, N-terminal region
CAY59_16240	COG4608	Belongs to the ABC transporter superfamily
CAY59_16245	COG0444	Belongs to the ABC transporter superfamily
CAY59_16250	COG0747	negative chemotaxis
CAY59_16255	COG4239	(ABC) transporter, permease
CAY59_16260	COG4174	ABC transporter (Permease)
CAY59_16265	COG4206	TonB-dependent receptor
CAY59_16280	COG0811	peptide transport
CAY59_16285	COG0848	biopolymer transport protein
CAY59_16300	COG0194	GDP metabolic process
CAY59_16305	COG1758	RNA polymerase activity
CAY59_16310	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CAY59_16315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CAY59_16320	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CAY59_16330	COG2233	PERMEase
CAY59_16335	COG2205	protein histidine kinase activity
CAY59_16340	COG0745	RESPONSE REGULATOR receiver
CAY59_16345	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CAY59_16355	COG2183	response to ionizing radiation
CAY59_16370	COG1040	competence protein
CAY59_16380	COG0494	nUDIX hydrolase
CAY59_16385	COG1218	3'(2'),5'-bisphosphate nucleotidase
CAY59_16395	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
CAY59_16400	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
CAY59_16405	COG3156	type II secretion system protein K
CAY59_16410	COG4795	General secretion pathway protein
CAY59_16415	COG2165	general secretion pathway protein
CAY59_16420	COG2165	general secretion pathway protein
CAY59_16425	COG2165	general secretion pathway protein
CAY59_16430	COG1459	type II secretion system
CAY59_16435	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CAY59_16445	COG3031	protein transport across the cell outer membrane
CAY59_16450	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CAY59_16470	COG0456	acetyltransferase
CAY59_16475	COG1490	D-aminoacyl-tRNA deacylase activity
CAY59_16505	COG0174	glutamine synthetase
CAY59_16515	COG3852	Histidine kinase
CAY59_16520	COG2204	response regulator
CAY59_16525	COG3300	MHYT domain
CAY59_16525	COG5001	Diguanylate cyclase
CAY59_16530	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CAY59_16560	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CAY59_16565	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CAY59_16565	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CAY59_16585	COG0084	hydrolase, TatD family'
CAY59_16590	COG0805	protein transport
CAY59_16610	COG3165	ubiquinone biosynthetic process from chorismate
CAY59_16635	COG1910	domain protein
CAY59_16655	COG2081	HI0933 family
CAY59_16670	COG0732	type I restriction modification DNA specificity domain
CAY59_16755	COG0732	type I restriction modification DNA specificity domain
CAY59_16790	COG2204	response regulator
CAY59_16805	COG3501	Rhs element vgr protein
CAY59_16830	COG0515	serine threonine protein kinase
CAY59_16860	COG1522	sequence-specific DNA binding
CAY59_16935	COG4771	TonB-dependent receptor
CAY59_16950	COG2205	protein histidine kinase activity
CAY59_16950	COG0784	Response regulator, receiver
CAY59_16955	COG3300	MHYT domain
CAY59_16955	COG5001	Diguanylate cyclase
CAY59_16960	COG2197	response regulator
CAY59_16965	COG3706	GGDEF domain
CAY59_16975	COG2197	response regulator
CAY59_16980	COG0778	Nitroreductase
CAY59_16990	COG0784	Response regulator, receiver
CAY59_16990	COG0835	chemotaxis
CAY59_17005	COG2962	Rard protein
CAY59_17020	COG0671	phosphoesterase, PA-phosphatase related
CAY59_17040	COG2076	Multidrug Resistance protein
CAY59_17075	COG2067	long-chain fatty acid transport protein
CAY59_17080	COG1234	tRNA 3'-trailer cleavage
CAY59_17090	COG0069	glutamate synthase activity
CAY59_17090	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CAY59_17105	COG2755	lipolytic protein G-D-S-L family
CAY59_17105	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CAY59_17115	COG1902	pentaerythritol trinitrate reductase activity
CAY59_17120	COG0346	lactoylglutathione lyase activity
CAY59_17150	COG2815	serine threonine protein kinase
CAY59_17150	COG0515	serine threonine protein kinase
CAY59_17185	COG0631	protein serine/threonine phosphatase activity
CAY59_17240	COG3501	Rhs element vgr protein
CAY59_17255	COG3209	COG3209 Rhs family protein
CAY59_17275	COG0420	3'-5' exonuclease activity
CAY59_17280	COG0419	ATPase involved in DNA repair
CAY59_17290	COG3469	chitinase activity
CAY59_17320	COG3040	lipid binding
CAY59_17330	COG2814	Major facilitator Superfamily
CAY59_17340	COG1288	antiporter activity
CAY59_17350	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CAY59_17365	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CAY59_17380	COG1472	Belongs to the glycosyl hydrolase 3 family
CAY59_17385	COG0583	DNA-binding transcription factor activity
CAY59_17400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CAY59_17475	COG2199	diguanylate cyclase activity
CAY59_17485	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CAY59_17490	COG2146	nitrite reductase [NAD(P)H] activity
CAY59_17495	COG2116	formate transmembrane transporter activity
CAY59_17515	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CAY59_17540	COG0534	Mate efflux family protein
CAY59_17550	COG2814	Major facilitator Superfamily
CAY59_17555	COG3118	belongs to the thioredoxin family
CAY59_17560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CAY59_17585	COG1566	PFAM secretion protein HlyD family protein
CAY59_17605	COG1482	cell wall glycoprotein biosynthetic process
CAY59_17615	COG3851	Histidine kinase
CAY59_17620	COG2197	response regulator
CAY59_17685	COG1328	CTP reductase activity
CAY59_17690	COG0602	queuosine metabolic process
CAY59_17695	COG0534	Mate efflux family protein
CAY59_17720	COG3111	PFAM Bacterial OB fold (BOF) protein
CAY59_17730	COG0725	ABC transporter, periplasmic molybdate-binding protein
CAY59_17735	COG4149	molybdate abc transporter
CAY59_17740	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CAY59_17750	COG2203	Gaf domain
CAY59_17750	COG3706	GGDEF domain
CAY59_17750	COG4251	negative regulation of phosphorylation
CAY59_17750	COG5001	Diguanylate cyclase
CAY59_17755	COG0745	RESPONSE REGULATOR receiver
CAY59_17755	COG3706	GGDEF domain
CAY59_17770	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CAY59_17775	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CAY59_17800	COG3140	Belongs to the UPF0181 family
CAY59_17890	COG0023	Translation Initiation Factor
CAY59_17910	COG0045	succinate-CoA ligase (ADP-forming) activity
CAY59_17910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CAY59_17910	COG1042	CoA-binding domain protein
CAY59_17915	COG0583	DNA-binding transcription factor activity
CAY59_17925	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CAY59_17940	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CAY59_17945	COG1984	allophanate hydrolase subunit 2
CAY59_17955	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CAY59_17960	COG4181	ATPase activity
CAY59_17970	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CAY59_17975	COG3300	MHYT domain
CAY59_17975	COG5001	Diguanylate cyclase
CAY59_17985	COG0484	heat shock protein binding
CAY59_18020	COG2050	protein possibly involved in aromatic compounds catabolism
CAY59_18025	COG0501	Belongs to the peptidase M48B family
CAY59_18035	COG2067	long-chain fatty acid transport protein
CAY59_18040	COG2267	carboxylic ester hydrolase activity
CAY59_18055	COG1410	methionine synthase
CAY59_18055	COG0646	methionine synthase
CAY59_18065	COG0861	Integral membrane protein TerC family
CAY59_18070	COG0737	Belongs to the 5'-nucleotidase family
CAY59_18075	COG3593	DNA synthesis involved in DNA repair
CAY59_18085	COG0583	DNA-binding transcription factor activity
CAY59_18095	COG2116	formate transmembrane transporter activity
CAY59_18105	COG3038	cytochrome b561
CAY59_18120	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CAY59_18125	COG0513	Belongs to the DEAD box helicase family
CAY59_18130	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
CAY59_18135	COG0840	transmembrane signaling receptor activity
CAY59_18140	COG0546	phosphoglycolate phosphatase activity
CAY59_18145	COG3437	response regulator, receiver
CAY59_18145	COG0784	Response regulator, receiver
CAY59_18160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAY59_18170	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CAY59_18180	COG2207	Transcriptional regulator
CAY59_18185	COG1979	alcohol dehydrogenase
CAY59_18195	COG1126	abc transporter atp-binding protein
CAY59_18200	COG0765	amino acid transport
CAY59_18205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAY59_18215	COG2200	EAL domain
CAY59_18215	COG2199	diguanylate cyclase activity
CAY59_18215	COG2203	Gaf domain
CAY59_18230	COG1609	Transcriptional regulator
CAY59_18235	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAY59_18235	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAY59_18240	COG1105	Belongs to the carbohydrate kinase PfkB family
CAY59_18245	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CAY59_18245	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CAY59_18245	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CAY59_18260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAY59_18265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAY59_18275	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CAY59_18285	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CAY59_18360	COG4977	sequence-specific DNA binding
CAY59_18370	COG1733	regulation of RNA biosynthetic process
CAY59_18380	COG0641	radical SAM
CAY59_18390	COG3119	arylsulfatase activity
CAY59_18410	COG0583	DNA-binding transcription factor activity
CAY59_18425	COG5640	endopeptidase activity
CAY59_18435	COG1132	(ABC) transporter
CAY59_18480	COG2814	Major facilitator Superfamily
CAY59_18560	COG3706	GGDEF domain
CAY59_18560	COG0745	RESPONSE REGULATOR receiver
CAY59_18565	COG0628	permease
CAY59_18615	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CAY59_18650	COG2146	nitrite reductase [NAD(P)H] activity
CAY59_18650	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CAY59_18655	COG1116	anion transmembrane transporter activity
CAY59_18660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAY59_18665	COG1116	anion transmembrane transporter activity
CAY59_18665	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CAY59_18675	COG3707	response regulator
CAY59_18695	COG0243	molybdopterin cofactor binding
CAY59_18700	COG0456	acetyltransferase
CAY59_18705	COG5002	protein histidine kinase activity
CAY59_18705	COG5001	Diguanylate cyclase
CAY59_18710	COG0814	amino acid
CAY59_18715	COG3706	GGDEF domain
CAY59_18735	COG1785	Belongs to the alkaline phosphatase family
CAY59_18750	COG0745	RESPONSE REGULATOR receiver
CAY59_18790	COG0443	Heat shock 70 kDa protein
CAY59_18835	COG2200	EAL domain
CAY59_18860	COG4160	amino acid transport
CAY59_18865	COG4215	(ABC) transporter
CAY59_18870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAY59_18875	COG1126	abc transporter atp-binding protein
CAY59_18925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CAY59_18935	COG1012	belongs to the aldehyde dehydrogenase family
CAY59_18950	COG1902	pentaerythritol trinitrate reductase activity
CAY59_18950	COG0446	pyridine nucleotide-disulphide oxidoreductase
CAY59_18965	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CAY59_18970	COG1845	cytochrome c oxidase, subunit III
CAY59_18975	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CAY59_18980	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CAY59_18990	COG1028	Short-chain dehydrogenase reductase Sdr
CAY59_19000	COG1024	Enoyl-CoA hydratase
CAY59_19005	COG1024	Enoyl-CoA hydratase
CAY59_19020	COG0183	Belongs to the thiolase family
CAY59_19030	COG1960	acyl-CoA dehydrogenase activity
CAY59_19035	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CAY59_19040	COG1024	Enoyl-CoA hydratase
CAY59_19080	COG3278	Belongs to the heme-copper respiratory oxidase family
CAY59_19095	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CAY59_19105	COG0513	Belongs to the DEAD box helicase family
CAY59_19125	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CAY59_19140	COG1119	ATPase activity
CAY59_19145	COG2200	EAL domain
CAY59_19165	COG0513	Belongs to the DEAD box helicase family
CAY59_19170	COG3447	MASE1 domain protein
CAY59_19170	COG5001	Diguanylate cyclase
CAY59_19170	COG5002	protein histidine kinase activity
CAY59_19175	COG0523	cobalamin synthesis protein
CAY59_19205	COG3530	Putative quorum-sensing-regulated virulence factor
CAY59_19235	COG3186	Phenylalanine-4-hydroxylase
CAY59_19245	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CAY59_19250	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CAY59_19270	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CAY59_19275	COG1454	alcohol dehydrogenase
CAY59_19280	COG2133	pyrroloquinoline quinone binding
CAY59_19285	COG1619	proteins homologs of microcin C7 resistance protein MccF
CAY59_19295	COG0783	Belongs to the Dps family
CAY59_19300	COG0840	transmembrane signaling receptor activity
CAY59_19310	COG1136	(ABC) transporter
CAY59_19310	COG0577	efflux transmembrane transporter activity
CAY59_19330	COG2199	diguanylate cyclase activity
CAY59_19340	COG3036	rescue of stalled ribosome
CAY59_19345	COG1278	Cold shock
CAY59_19375	COG0545	Peptidyl-prolyl cis-trans isomerase
CAY59_19380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CAY59_19415	COG2195	Cleaves the N-terminal amino acid of tripeptides
CAY59_19430	COG2197	response regulator
CAY59_19440	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CAY59_19460	COG3005	denitrification pathway
CAY59_19480	COG0183	Belongs to the thiolase family
CAY59_19490	COG1280	lysine exporter protein (LysE YggA)
CAY59_19500	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CAY59_19505	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CAY59_19590	COG0673	inositol 2-dehydrogenase activity
CAY59_19595	COG0784	Response regulator, receiver
CAY59_19595	COG2205	protein histidine kinase activity
CAY59_19595	COG5002	protein histidine kinase activity
CAY59_19615	COG0583	DNA-binding transcription factor activity
CAY59_19630	COG0531	amino acid
CAY59_19645	COG2205	protein histidine kinase activity
CAY59_19650	COG0745	RESPONSE REGULATOR receiver
CAY59_19675	COG1566	PFAM secretion protein HlyD family protein
CAY59_19680	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CAY59_19685	COG2239	Acts as a magnesium transporter
CAY59_19690	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CAY59_19695	COG0402	S-adenosylhomocysteine deaminase activity
CAY59_19710	COG1418	mRNA catabolic process
CAY59_19725	COG2814	Major facilitator Superfamily
CAY59_19735	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CAY59_19755	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CAY59_19770	COG4221	oxidoreductase activity
CAY59_19775	COG0745	RESPONSE REGULATOR receiver
CAY59_19780	COG2205	protein histidine kinase activity
CAY59_19790	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CAY59_19795	COG2194	sulfuric ester hydrolase activity
CAY59_19805	COG0673	inositol 2-dehydrogenase activity
CAY59_19810	COG4977	sequence-specific DNA binding
CAY59_19820	COG2814	Major facilitator Superfamily
CAY59_19840	COG0583	DNA-binding transcription factor activity
CAY59_19845	COG2249	NAD(P)H dehydrogenase (quinone) activity
CAY59_19860	COG0583	DNA-binding transcription factor activity
CAY59_19900	COG0366	Alpha amylase catalytic
CAY59_19905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CAY59_19910	COG0835	chemotaxis
CAY59_19910	COG0784	Response regulator, receiver
CAY59_19925	COG0748	coenzyme F420 binding
CAY59_19930	COG3721	Heme iron utilization protein
CAY59_19940	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CAY59_19945	COG0811	peptide transport
CAY59_19950	COG0848	biopolymer transport protein
CAY59_19960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAY59_19965	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CAY59_20005	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CAY59_20015	COG0633	Ferredoxin
CAY59_20015	COG0633	Ferredoxin
CAY59_20015	COG3217	Mosc domain protein beta barrel domain protein
CAY59_20015	COG3217	Mosc domain protein beta barrel domain protein
CAY59_20020	COG0401	homolog of Blt101
CAY59_20065	COG1175	transmembrane transport
CAY59_20080	COG3842	ATPase activity
CAY59_20120	COG3206	protein involved in exopolysaccharide biosynthesis
CAY59_20120	COG0489	protein tyrosine kinase activity
CAY59_20165	COG1309	transcriptional regulator
CAY59_20170	COG2130	NADP-dependent
CAY59_20180	COG0753	catalase activity
CAY59_20185	COG2084	Dehydrogenase
CAY59_20195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CAY59_20200	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CAY59_20265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CAY59_20270	COG1301	dicarboxylic acid transport
CAY59_20275	COG1252	NADH dehydrogenase
CAY59_20285	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
CAY59_20290	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CAY59_20305	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CAY59_20305	COG2885	chlorophyll binding
CAY59_20325	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CAY59_20325	COG2885	chlorophyll binding
CAY59_20340	COG1028	Short-chain dehydrogenase reductase Sdr
CAY59_20345	COG3852	Histidine kinase
CAY59_20355	COG0110	maltose O-acetyltransferase activity
CAY59_20380	COG2197	response regulator
CAY59_20410	COG0714	Associated with various cellular activities
CAY59_20430	COG2304	oxidoreductase activity
CAY59_20450	COG0581	inorganic phosphate transmembrane transporter activity
CAY59_20455	COG0573	inorganic phosphate transmembrane transporter activity
CAY59_20460	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CAY59_20485	COG4771	TonB-dependent receptor
CAY59_20490	COG1770	oligopeptidase
CAY59_20495	COG0513	Belongs to the DEAD box helicase family
CAY59_20505	COG1388	LysM domain
CAY59_20505	COG1376	ErfK ybiS ycfS ynhG family protein
CAY59_20510	COG0415	Belongs to the DNA photolyase family
CAY59_20515	COG0789	Transcriptional regulator
CAY59_20520	COG3272	Protein of unknown function (DUF1722)
CAY59_20525	COG0813	purine-nucleoside phosphorylase activity
CAY59_20540	COG3706	GGDEF domain
CAY59_20555	COG1566	PFAM secretion protein HlyD family protein
CAY59_20565	COG1122	ATPase activity
CAY59_20595	COG0348	domain, Protein
CAY59_20600	COG0437	4 iron, 4 sulfur cluster binding
CAY59_20605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CAY59_20625	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CAY59_20635	COG1067	ATP-dependent peptidase activity
CAY59_20645	COG4172	Belongs to the ABC transporter superfamily
CAY59_20650	COG1505	serine-type exopeptidase activity
CAY59_20655	COG0583	DNA-binding transcription factor activity
CAY59_20665	COG1304	FMN binding
CAY59_20675	COG0668	transmembrane transport
CAY59_20685	COG1063	alcohol dehydrogenase
CAY59_20690	COG2223	nitrite transmembrane transporter activity
CAY59_20695	COG2203	Gaf domain
CAY59_20695	COG2199	diguanylate cyclase activity
CAY59_20720	COG1063	alcohol dehydrogenase
CAY59_20890	COG1403	HNH endonuclease
CAY59_20915	COG4626	Terminase
CAY59_20915	COG1802	Transcriptional regulator
CAY59_20950	COG0515	serine threonine protein kinase
CAY59_20950	COG2815	serine threonine protein kinase
CAY59_20965	COG5532	Uncharacterized conserved protein (DUF2303)
CAY59_20985	COG0582	viral genome integration into host DNA
CAY59_21000	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CAY59_21025	COG1063	alcohol dehydrogenase
CAY59_21030	COG0156	8-amino-7-oxononanoate synthase activity
CAY59_21055	COG0745	RESPONSE REGULATOR receiver
CAY59_21080	COG0346	lactoylglutathione lyase activity
CAY59_21145	COG3121	Chaperone
CAY59_21155	COG3188	usher protein
CAY59_21160	COG3121	Chaperone
CAY59_21185	COG2200	EAL domain
CAY59_21205	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CAY59_21220	COG2204	response regulator
CAY59_21245	COG1987	bacterial-type flagellum assembly
CAY59_21255	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CAY59_21270	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CAY59_21280	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CAY59_21285	COG1516	flagellar protein fliS
CAY59_21300	COG1580	Controls the rotational direction of flagella during chemotaxis
CAY59_21305	COG1191	sigma factor activity
CAY59_21310	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CAY59_21315	COG1360	Flagellar Motor Protein
CAY59_21340	COG0384	phenazine biosynthesis protein PhzF
CAY59_21385	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CAY59_21395	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CAY59_21400	COG1473	amidohydrolase
CAY59_21410	COG1522	sequence-specific DNA binding
CAY59_21450	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CAY59_21455	COG1256	bacterial-type flagellum assembly
CAY59_21455	COG4786	Flagellar basal body rod
CAY59_21470	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CAY59_21475	COG4786	Flagellar basal body rod
CAY59_21480	COG4787	bacterial-type flagellum-dependent cell motility
CAY59_21485	COG1749	Flagellar hook protein flgE
CAY59_21490	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CAY59_21495	COG1558	bacterial-type flagellum-dependent cell motility
CAY59_21500	COG1815	bacterial-type flagellum-dependent cell motility
CAY59_21520	COG1388	LysM domain
CAY59_21520	COG0741	lytic transglycosylase activity
CAY59_21545	COG1760	l-serine dehydratase
CAY59_21575	COG0583	DNA-binding transcription factor activity
CAY59_21585	COG2866	Carboxypeptidase
CAY59_21590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAY59_21600	COG2990	Protein conserved in bacteria
CAY59_21625	COG3842	ATPase activity
CAY59_21635	COG1840	ABC-type Fe3 transport system, periplasmic component
CAY59_21655	COG1609	Transcriptional regulator
CAY59_21710	COG1011	Hydrolase
CAY59_21745	COG1765	OsmC-like protein
CAY59_21750	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CAY59_21750	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CAY59_21765	COG3046	protein related to deoxyribodipyrimidine photolyase
CAY59_21770	COG0415	Belongs to the DNA photolyase family
CAY59_21775	COG3706	GGDEF domain
CAY59_21810	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CAY59_21815	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CAY59_21835	COG3033	Beta-eliminating lyase
CAY59_21855	COG0579	oxidoreductase
CAY59_21870	COG1114	Component of the transport system for branched-chain amino acids
CAY59_21915	COG0583	DNA-binding transcription factor activity
CAY59_21925	COG0189	ligase activity
CAY59_21930	COG0189	ligase activity
CAY59_21930	COG4067	protein conserved in archaea
CAY59_21940	COG1166	arginine decarboxylase activity
CAY59_21945	COG0010	Belongs to the arginase family
CAY59_21950	COG2814	Major facilitator Superfamily
CAY59_21955	COG1770	oligopeptidase
CAY59_21970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CAY59_21975	COG1121	(ABC) transporter
CAY59_21980	COG0803	Belongs to the bacterial solute-binding protein 9 family
CAY59_22025	COG0848	biopolymer transport protein
CAY59_22030	COG0811	peptide transport
CAY59_22035	COG0811	peptide transport
CAY59_22055	COG0745	RESPONSE REGULATOR receiver
CAY59_22060	COG0584	glycerophosphoryl diester phosphodiesterase
CAY59_22070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CAY59_22130	COG0312	modulator of DNA gyrase
CAY59_22135	COG0312	modulator of DNA gyrase
CAY59_22145	COG0351	phosphomethylpyrimidine kinase
CAY59_22150	COG1116	anion transmembrane transporter activity
CAY59_22155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAY59_22160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CAY59_22165	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CAY59_22180	COG0671	phosphoesterase, PA-phosphatase related
CAY59_22185	COG0243	molybdopterin cofactor binding
CAY59_22190	COG3005	denitrification pathway
CAY59_22200	COG1028	Short-chain dehydrogenase reductase Sdr
CAY59_22220	COG0456	acetyltransferase
CAY59_22260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CAY59_22265	COG1929	Belongs to the glycerate kinase type-1 family
CAY59_22270	COG3835	regulator
CAY59_22345	COG0583	DNA-binding transcription factor activity
CAY59_22375	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CAY59_22375	COG3408	Glycogen debranching enzyme
CAY59_22395	COG2814	Major facilitator Superfamily
CAY59_22405	COG3047	cAMP biosynthetic process
CAY59_22410	COG1357	PFAM Pentapeptide repeats (8 copies)
CAY59_22425	COG0534	Mate efflux family protein
CAY59_22440	COG2076	Multidrug Resistance protein
CAY59_22495	COG0583	DNA-binding transcription factor activity
CAY59_22515	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CAY59_22530	COG3152	Membrane
CAY59_22550	COG0561	phosphatase activity
CAY59_22560	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CAY59_22565	COG0564	pseudouridine synthase activity
CAY59_22570	COG0534	Mate efflux family protein
CAY59_22575	COG1472	Belongs to the glycosyl hydrolase 3 family
CAY59_22590	COG1609	Transcriptional regulator
CAY59_22600	COG4608	Belongs to the ABC transporter superfamily
CAY59_22605	COG0444	Belongs to the ABC transporter superfamily
CAY59_22610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAY59_22620	COG0747	negative chemotaxis
CAY59_22630	COG1609	Transcriptional regulator
CAY59_22635	COG3842	ATPase activity
CAY59_22640	COG2723	6-phospho-beta-galactosidase activity
CAY59_22645	COG0395	ABC-type sugar transport system, permease component
CAY59_22660	COG1609	Transcriptional regulator
CAY59_22670	COG5001	Diguanylate cyclase
CAY59_22720	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CAY59_22730	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CAY59_22735	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CAY59_22745	COG2259	Doxx family
CAY59_22775	COG3338	carbonate dehydratase activity
CAY59_22795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CAY59_22800	COG0251	oxidation-reduction process
CAY59_22815	COG0659	secondary active sulfate transmembrane transporter activity
CAY59_22835	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CAY59_22840	COG2207	Transcriptional regulator
CAY59_22850	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CAY59_22895	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CAY59_22920	COG0786	glutamate:sodium symporter activity
CAY59_22925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CAY59_22930	COG1131	(ABC) transporter
CAY59_22965	COG1028	Short-chain dehydrogenase reductase Sdr
CAY59_22970	COG0786	glutamate:sodium symporter activity
CAY59_22990	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CAY59_23000	COG3279	Response regulator of the LytR AlgR family
CAY59_23005	COG3275	phosphorelay sensor kinase activity
CAY59_23040	COG1566	PFAM secretion protein HlyD family protein
CAY59_23055	COG0772	Belongs to the SEDS family
CAY59_23080	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CAY59_23080	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
CAY59_23090	COG0444	Belongs to the ABC transporter superfamily
CAY59_23095	COG4608	Belongs to the ABC transporter superfamily
CAY59_23130	COG1444	tRNA N-acetyltransferase activity
CAY59_23155	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CAY59_23160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CAY59_23160	COG1263	PTS System
CAY59_23165	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CAY59_23180	COG4166	transmembrane transport
CAY59_23300	COG1132	(ABC) transporter
CAY59_23335	COG0800	Aldolase
CAY59_23340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAY59_23345	COG1904	glucuronate isomerase
CAY59_23350	COG0246	Mannitol dehydrogenase
CAY59_23360	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CAY59_23370	COG2186	Transcriptional regulator
CAY59_23375	COG1312	Catalyzes the dehydration of D-mannonate
CAY59_23395	COG0513	Belongs to the DEAD box helicase family
CAY59_23400	COG3713	MltA-interacting MipA family protein
CAY59_23410	COG2153	protein acetylation
CAY59_23415	COG2258	MOSC domain
CAY59_23430	COG0544	peptidyl-prolyl cis-trans isomerase activity
CAY59_23435	COG1522	sequence-specific DNA binding
CAY59_23445	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CAY59_23490	COG0366	Alpha amylase catalytic
CAY59_23495	COG0583	DNA-binding transcription factor activity
CAY59_23500	COG1349	DNA-binding transcription factor activity
CAY59_23505	COG2084	Dehydrogenase
CAY59_23520	COG3622	Belongs to the hyi family
CAY59_23525	COG2610	gluconate transmembrane transporter activity
CAY59_23565	COG3634	alkyl hydroperoxide reductase activity
CAY59_23570	COG0450	alkyl hydroperoxide reductase
CAY59_23575	COG1846	Transcriptional regulator
CAY59_23580	COG1764	response to oxidative stress
CAY59_23625	COG1335	isochorismatase
CAY59_23640	COG0463	Glycosyl transferase, family 2
CAY59_23675	COG0840	transmembrane signaling receptor activity
CAY59_23680	COG0612	Peptidase, M16
CAY59_23705	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CAY59_23710	COG0383	alpha-mannosidase activity
CAY59_23720	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CAY59_23720	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CAY59_23720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAY59_23745	COG3188	usher protein
CAY59_23750	COG3121	Chaperone
CAY59_23775	COG2188	Transcriptional regulator
CAY59_23785	COG1263	PTS System
CAY59_23785	COG2190	(PTS) system
CAY59_23785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CAY59_23790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAY59_23795	COG0800	Aldolase
CAY59_23810	COG0739	heme binding
CAY59_23840	COG2814	Major facilitator Superfamily
CAY59_23850	COG1609	Transcriptional regulator
CAY59_23875	COG1760	l-serine dehydratase
CAY59_23885	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CAY59_23905	COG2203	Gaf domain
CAY59_23905	COG2199	diguanylate cyclase activity
CAY59_23915	COG4580	involved in the transport of maltose and maltodextrins
CAY59_23935	COG2356	endonuclease I
CAY59_23955	COG1982	Orn Lys Arg decarboxylase major
CAY59_23960	COG0531	amino acid
CAY59_23985	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CAY59_23990	COG0183	Belongs to the thiolase family
CAY59_24010	COG0477	Major facilitator Superfamily
CAY59_24010	COG2814	Major facilitator Superfamily
CAY59_24020	COG3962	Belongs to the TPP enzyme family
CAY59_24025	COG0673	inositol 2-dehydrogenase activity
CAY59_24030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAY59_24055	COG0673	inositol 2-dehydrogenase activity
CAY59_24065	COG1162	GTPase activity
CAY59_24105	COG0058	SHG alpha-glucan phosphorylase activity
CAY59_24110	COG1640	4-alpha-glucanotransferase
CAY59_24115	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CAY59_24120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CAY59_24125	COG0366	Alpha amylase catalytic
CAY59_24140	COG3366	ferrous iron transmembrane transporter activity
CAY59_24145	COG0700	Nucleoside recognition
CAY59_24150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CAY59_24155	COG3339	Conserved Protein
CAY59_24160	COG1301	dicarboxylic acid transport
CAY59_24195	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CAY59_24200	COG1596	polysaccharide export
CAY59_24215	COG2095	MarC family integral membrane protein
CAY59_24220	COG4667	esterase of the alpha-beta hydrolase superfamily
CAY59_24230	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CAY59_24235	COG0415	Belongs to the DNA photolyase family
CAY59_24260	COG1686	Belongs to the peptidase S11 family
CAY59_24270	COG0583	DNA-binding transcription factor activity
CAY59_24275	COG4628	conserved protein (DUF2132)
CAY59_24285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CAY59_24300	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
CAY59_24305	COG0628	permease
CAY59_24345	COG2988	succinylglutamate desuccinylase activity
CAY59_24355	COG2814	Major facilitator Superfamily
CAY59_24365	COG0454	-acetyltransferase
CAY59_24375	COG0745	RESPONSE REGULATOR receiver
CAY59_24380	COG2205	protein histidine kinase activity
CAY59_24395	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CAY59_24400	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CAY59_24445	COG0251	oxidation-reduction process
CAY59_24455	COG1294	oxidase, subunit
CAY59_24460	COG1271	oxidase subunit
CAY59_24475	COG3220	belongs to the UPF0276 family
CAY59_24490	COG0384	phenazine biosynthesis protein PhzF
CAY59_24495	COG0346	lactoylglutathione lyase activity
CAY59_24510	COG0488	(ABC) transporter
CAY59_24515	COG4628	conserved protein (DUF2132)
CAY59_24530	COG0583	DNA-binding transcription factor activity
CAY59_24540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CAY59_24545	COG1280	lysine exporter protein (LysE YggA)
CAY59_24575	COG0737	Belongs to the 5'-nucleotidase family
CAY59_24580	COG3537	Alpha-1,2-mannosidase
CAY59_24585	COG3537	Alpha-1,2-mannosidase
CAY59_24595	COG3537	Alpha-1,2-mannosidase
CAY59_24600	COG3537	Alpha-1,2-mannosidase
CAY59_24605	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CAY59_24615	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CAY59_24615	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CAY59_24620	COG0346	lactoylglutathione lyase activity
CAY59_24625	COG1349	DNA-binding transcription factor activity
CAY59_24640	COG0753	catalase activity
CAY59_24700	COG0583	DNA-binding transcription factor activity
CAY59_24705	COG0589	response to stress
CAY59_24710	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CAY59_24725	COG4175	Glycine betaine
CAY59_24725	COG3448	diguanylate cyclase activity
CAY59_24730	COG4176	ABC-type proline glycine betaine transport system permease component
CAY59_24740	COG1342	Belongs to the UPF0251 family
CAY59_24760	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CAY59_24770	COG4948	Mandelate Racemase Muconate Lactonizing
CAY59_24810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CAY59_24820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAY59_24835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAY59_24845	COG1309	transcriptional regulator
CAY59_24855	COG0318	PFAM AMP-dependent synthetase and ligase
CAY59_24860	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CAY59_24890	COG0786	glutamate:sodium symporter activity
CAY59_24895	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CAY59_24910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAY59_24915	COG0583	DNA-binding transcription factor activity
CAY59_24950	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CAY59_24955	COG2197	response regulator
CAY59_24975	COG0252	asparaginase activity
CAY59_24995	COG0583	DNA-binding transcription factor activity
CAY59_25005	COG2321	neutral zinc metallopeptidase
CAY59_25010	COG3122	Protein conserved in bacteria
CAY59_25025	COG2255	four-way junction helicase activity
CAY59_25035	COG3853	Toxic anion resistance protein (TelA)
CAY59_25045	COG1902	pentaerythritol trinitrate reductase activity
CAY59_25065	COG0583	DNA-binding transcription factor activity
CAY59_25075	COG0513	Belongs to the DEAD box helicase family
CAY59_25120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CAY59_25145	COG3746	phosphate-selective porin O and P
CAY59_25175	COG1028	Short-chain dehydrogenase reductase Sdr
CAY59_25220	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CAY59_25230	COG0625	glutathione transferase activity
CAY59_25235	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CAY59_25240	COG1686	Belongs to the peptidase S11 family
CAY59_25250	COG2226	methyltransferase
CAY59_25275	COG3706	GGDEF domain
CAY59_25275	COG0745	RESPONSE REGULATOR receiver
CAY59_25280	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CAY59_25295	COG1278	Cold shock
CAY59_25300	COG1741	Belongs to the pirin family
CAY59_25305	COG4667	esterase of the alpha-beta hydrolase superfamily
CAY59_25315	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CAY59_25325	COG0523	cobalamin synthesis protein
CAY59_25335	COG1846	Transcriptional regulator
CAY59_25350	COG3842	ATPase activity
CAY59_25355	COG0395	ABC-type sugar transport system, permease component
CAY59_25360	COG1175	transmembrane transport
CAY59_25380	COG0589	response to stress
CAY59_25390	COG0488	(ABC) transporter
CAY59_25395	COG1505	serine-type exopeptidase activity
CAY59_25405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAY59_25415	COG2067	long-chain fatty acid transport protein
CAY59_25425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CAY59_25430	COG1858	cytochrome C peroxidase
CAY59_25445	COG0494	nUDIX hydrolase
CAY59_25490	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAY59_25515	COG3383	formate dehydrogenase (NAD+) activity
CAY59_25535	COG0842	Transport permease protein
CAY59_25540	COG1131	(ABC) transporter
CAY59_25550	COG0840	transmembrane signaling receptor activity
CAY59_25565	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CAY59_25575	COG4145	pantothenate transmembrane transporter activity
CAY59_25580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAY59_25585	COG0800	Aldolase
CAY59_25595	COG2706	6-phosphogluconolactonase activity
CAY59_25610	COG1881	PFAM PEBP family protein
CAY59_25625	COG0798	PFAM Bile acid sodium symporter
CAY59_25640	COG1733	regulation of RNA biosynthetic process
CAY59_25650	COG0747	negative chemotaxis
CAY59_25655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAY59_25660	COG2213	PTS system mannitol-specific
CAY59_25665	COG1063	alcohol dehydrogenase
CAY59_25680	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CAY59_25700	COG0814	amino acid
CAY59_25735	COG0739	heme binding
CAY59_25745	COG0583	DNA-binding transcription factor activity
CAY59_25750	COG2814	Major facilitator Superfamily
CAY59_25765	COG0697	spore germination
CAY59_25780	COG0179	Fumarylacetoacetate (FAA) hydrolase
CAY59_25800	COG1280	lysine exporter protein (LysE YggA)
CAY59_25810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CAY59_25820	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CAY59_25825	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CAY59_25850	COG1612	heme a metabolic process
CAY59_25865	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CAY59_25870	COG2814	Major facilitator Superfamily
CAY59_25880	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CAY59_25910	COG2897	thiosulfate sulfurtransferase activity
CAY59_25965	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CAY59_25970	COG0303	'Molybdopterin
CAY59_25985	COG1914	H( )-stimulated, divalent metal cation uptake system
CAY59_26010	COG4989	oxidoreductase activity
CAY59_26025	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CAY59_26025	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CAY59_26045	COG1073	alpha beta
CAY59_26055	COG0583	DNA-binding transcription factor activity
CAY59_26085	COG0455	bacterial-type flagellum organization
CAY59_26125	COG2885	chlorophyll binding
CAY59_26155	COG3706	GGDEF domain
CAY59_26180	COG4176	ABC-type proline glycine betaine transport system permease component
CAY59_26195	COG0330	HflC and HflK could
CAY59_26225	COG2205	protein histidine kinase activity
CAY59_26225	COG0784	Response regulator, receiver
CAY59_26270	COG0586	Pfam SNARE associated Golgi protein
CAY59_26295	COG1051	belongs to the nudix hydrolase family
CAY59_26300	COG1794	racemase activity, acting on amino acids and derivatives
CAY59_26305	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CAY59_26310	COG5001	Diguanylate cyclase
CAY59_26320	COG1129	ABC transporter
CAY59_26325	COG1172	Belongs to the binding-protein-dependent transport system permease family
CAY59_26330	COG1879	ABC-type sugar transport system periplasmic component
CAY59_26335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAY59_26340	COG1609	Transcriptional regulator
CAY59_26355	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CAY59_26370	COG4607	ABC-type enterochelin transport system periplasmic component
CAY59_26375	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAY59_26380	COG4605	iron ion homeostasis
CAY59_26385	COG4604	ABC transporter, ATP-binding protein
CAY59_26390	COG0789	Transcriptional regulator
CAY59_26415	COG1289	transmembrane transporter activity
CAY59_26420	COG0210	DNA helicase
CAY59_26430	COG1879	ABC-type sugar transport system periplasmic component
CAY59_26435	COG2205	protein histidine kinase activity
CAY59_26435	COG2198	Histidine kinase
CAY59_26435	COG0784	Response regulator, receiver
CAY59_26465	COG3119	arylsulfatase activity
CAY59_26470	COG3119	arylsulfatase activity
CAY59_26475	COG3063	Type IV pilus biogenesis stability protein PilW
CAY59_26480	COG0714	Associated with various cellular activities
CAY59_26540	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CAY59_26550	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CAY59_26560	COG0583	DNA-binding transcription factor activity
CAY59_26565	COG1597	lipid kinase activity
CAY59_26570	COG3111	PFAM Bacterial OB fold (BOF) protein
CAY59_26590	COG0641	radical SAM
CAY59_26615	COG0501	Belongs to the peptidase M48B family
CAY59_26620	COG1704	LemA family
CAY59_26625	COG3069	C4-dicarboxylate transmembrane transporter activity
CAY59_26655	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CAY59_26660	COG0739	heme binding
CAY59_26695	COG2081	HI0933 family
CAY59_26810	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CAY59_26835	COG3015	lipoprotein NlpE involved in copper resistance
CAY59_26910	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CAY59_27105	COG1192	Involved in chromosome partitioning
CAY59_27150	COG2003	Belongs to the UPF0758 family
CAY59_27165	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CAY59_27195	COG3501	Rhs element vgr protein
CAY59_27210	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CAY59_27515	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CAY59_27550	COG3504	Conjugal transfer protein
CAY59_27565	COG4962	Type ii secretion system protein e
CAY59_27575	COG3451	type IV secretory pathway VirB4
CAY59_27580	COG5268	conjugation
CAY59_27625	COG1192	Involved in chromosome partitioning
CAY59_27655	COG0419	ATPase involved in DNA repair
CAY59_27775	COG4932	domain protein
CAY59_27775	COG5492	domain, Protein
CAY59_27820	COG1192	Involved in chromosome partitioning
CAY59_27925	COG0739	heme binding
CAY59_27935	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CAY59_27965	COG5492	domain, Protein
CAY59_27965	COG4932	domain protein
CAY59_27995	COG4974	Belongs to the 'phage' integrase family
CAY59_28005	COG2337	Toxic component of a toxin-antitoxin (TA) module
CAY59_28060	COG2885	chlorophyll binding
CAY59_28125	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CAY59_28140	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CAY59_28240	COG3451	type IV secretory pathway VirB4
CAY59_28255	COG3701	Conjugal transfer protein
CAY59_28270	COG2948	multi-organism process
CAY59_28290	COG2885	chlorophyll binding
CAY59_28290	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CAY59_28310	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CAY59_28385	COG4962	Type ii secretion system protein e