locus-tag	class	description
HB760_00045	COG0583	DNA-binding transcription factor activity
HB760_00050	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HB760_00055	COG2960	long-chain fatty acid transporting porin activity
HB760_00060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB760_00065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB760_00115	COG4172	Belongs to the ABC transporter superfamily
HB760_00120	COG4166	transmembrane transport
HB760_00125	COG0601	transmembrane transport
HB760_00130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB760_00160	COG0515	serine threonine protein kinase
HB760_00175	COG0800	Aldolase
HB760_00180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB760_00190	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HB760_00200	COG1522	sequence-specific DNA binding
HB760_00205	COG5001	Diguanylate cyclase
HB760_00205	COG5002	protein histidine kinase activity
HB760_00225	COG0589	response to stress
HB760_00230	COG1528	Iron-storage protein
HB760_00240	COG2081	HI0933 family
HB760_00260	COG1910	domain protein
HB760_00275	COG1322	Protein conserved in bacteria
HB760_00285	COG3165	ubiquinone biosynthetic process from chorismate
HB760_00300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HB760_00305	COG0805	protein transport
HB760_00310	COG0084	hydrolase, TatD family'
HB760_00325	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HB760_00325	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HB760_00330	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HB760_00360	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HB760_00370	COG2204	response regulator
HB760_00375	COG3852	Histidine kinase
HB760_00385	COG0174	glutamine synthetase
HB760_00390	COG1217	gtp-binding protein TYPA
HB760_00410	COG1490	D-aminoacyl-tRNA deacylase activity
HB760_00415	COG0456	acetyltransferase
HB760_00435	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HB760_00440	COG3031	protein transport across the cell outer membrane
HB760_00450	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HB760_00455	COG1459	type II secretion system
HB760_00460	COG2165	general secretion pathway protein
HB760_00465	COG2165	general secretion pathway protein
HB760_00470	COG2165	general secretion pathway protein
HB760_00475	COG4795	General secretion pathway protein
HB760_00480	COG3156	type II secretion system protein K
HB760_00485	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HB760_00490	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HB760_00500	COG1218	3'(2'),5'-bisphosphate nucleotidase
HB760_00505	COG0494	nUDIX hydrolase
HB760_00515	COG1040	competence protein
HB760_00530	COG2183	response to ionizing radiation
HB760_00540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HB760_00555	COG2233	PERMEase
HB760_00565	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HB760_00570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HB760_00575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HB760_00580	COG1758	RNA polymerase activity
HB760_00585	COG0194	GDP metabolic process
HB760_00600	COG0848	biopolymer transport protein
HB760_00605	COG0811	peptide transport
HB760_00625	COG4174	ABC transporter (Permease)
HB760_00630	COG4239	(ABC) transporter, permease
HB760_00640	COG0444	Belongs to the ABC transporter superfamily
HB760_00645	COG4608	Belongs to the ABC transporter superfamily
HB760_00655	COG1561	YicC-like family, N-terminal region
HB760_00660	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HB760_00665	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HB760_00670	COG1560	Kdo2-lipid A biosynthetic process
HB760_00680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HB760_00700	COG2194	sulfuric ester hydrolase activity
HB760_00720	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HB760_00735	COG0463	Glycosyl transferase, family 2
HB760_00740	COG0859	PFAM glycosyl transferase family 9
HB760_00745	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HB760_00750	COG3642	lipopolysaccharide core region biosynthetic process
HB760_00770	COG1519	Transferase
HB760_00785	COG1560	Kdo2-lipid A biosynthetic process
HB760_00795	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HB760_00855	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HB760_00860	COG1181	Belongs to the D-alanine--D-alanine ligase family
HB760_00875	COG0463	Glycosyl transferase, family 2
HB760_00880	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HB760_00890	COG1216	Glycosyl transferase, family 2
HB760_00895	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HB760_00910	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HB760_00915	COG0149	triose-phosphate isomerase activity
HB760_00945	COG1494	fructose-1,6-bisphosphatase
HB760_00955	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HB760_00960	COG1575	Belongs to the MenA family. Type 1 subfamily
HB760_00980	COG1609	Transcriptional regulator
HB760_00985	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HB760_01005	COG0088	Forms part of the polypeptide exit tunnel
HB760_01090	COG1841	ribosomal large subunit assembly
HB760_01100	COG0201	protein transport
HB760_01105	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HB760_01110	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HB760_01115	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HB760_01125	COG0202	RNA polymerase activity
HB760_01130	COG0203	ribosomal protein L17
HB760_01140	COG0545	Peptidyl-prolyl cis-trans isomerase
HB760_01155	COG2153	protein acetylation
HB760_01160	COG0513	Belongs to the DEAD box helicase family
HB760_01170	COG0737	Belongs to the 5'-nucleotidase family
HB760_01175	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HB760_01175	COG1648	precorrin-2 dehydrogenase activity
HB760_01190	COG0471	metal ion transport
HB760_01190	COG3273	potassium ion transport
HB760_01195	COG0529	Catalyzes the synthesis of activated sulfate
HB760_01215	COG1136	(ABC) transporter
HB760_01230	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HB760_01240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HB760_01250	COG2911	Protein conserved in bacteria
HB760_01255	COG2105	PFAM AIG2 family protein
HB760_01265	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HB760_01275	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HB760_01280	COG0163	prenyltransferase activity
HB760_01285	COG4143	(ABC) transporter
HB760_01290	COG1178	ABC-type Fe3 transport system permease component
HB760_01295	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HB760_01310	COG2358	TRAP transporter, solute receptor (TAXI family
HB760_01330	COG0142	geranyltranstransferase activity
HB760_01335	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HB760_01350	COG2966	Psort location CytoplasmicMembrane, score
HB760_01355	COG3610	response to peptide
HB760_01360	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HB760_01380	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HB760_01385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HB760_01390	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HB760_01395	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HB760_01415	COG0473	3-isopropylmalate dehydrogenase activity
HB760_01420	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HB760_01440	COG0583	DNA-binding transcription factor activity
HB760_01445	COG1022	Amp-dependent synthetase and ligase
HB760_01450	COG0028	Belongs to the TPP enzyme family
HB760_01455	COG0440	acetolactate synthase activity
HB760_01460	COG3706	GGDEF domain
HB760_01470	COG0469	pyruvate kinase activity
HB760_01475	COG1349	DNA-binding transcription factor activity
HB760_01480	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HB760_01515	COG0582	viral genome integration into host DNA
HB760_01605	COG0358	DNA primase activity
HB760_01610	COG1610	YqeY-like protein
HB760_01615	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HB760_01620	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HB760_01625	COG0596	Alpha beta hydrolase
HB760_01635	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HB760_01640	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HB760_01655	COG3409	Peptidoglycan-binding domain 1 protein
HB760_01655	COG3267	Type II secretory pathway component ExeA
HB760_01665	COG4991	sh3 domain protein
HB760_01670	COG0306	phosphate transporter
HB760_01675	COG1392	Phosphate transport regulator
HB760_01680	COG3025	triphosphatase activity
HB760_01685	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HB760_01695	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HB760_01705	COG1538	Outer membrane efflux protein
HB760_01710	COG0494	nUDIX hydrolase
HB760_01715	COG3151	Protein conserved in bacteria
HB760_01725	COG3150	esterase
HB760_01735	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HB760_01740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HB760_01745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HB760_01750	COG3105	Protein conserved in bacteria
HB760_01755	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HB760_01770	COG0723	plastoquinol--plastocyanin reductase activity
HB760_01775	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HB760_01780	COG2857	Cytochrome c1
HB760_01785	COG0625	glutathione transferase activity
HB760_01790	COG2969	positive regulation of protein catabolic process
HB760_01795	COG2823	Periplasmic or secreted lipoprotein
HB760_01800	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HB760_01815	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HB760_01830	COG3116	cell division
HB760_01835	COG0768	penicillin binding
HB760_01840	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HB760_01845	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HB760_01860	COG0772	Belongs to the SEDS family
HB760_01875	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HB760_01880	COG0849	cell division
HB760_01885	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HB760_01905	COG0494	nUDIX hydrolase
HB760_01915	COG0505	Belongs to the CarA family
HB760_01920	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HB760_01925	COG0730	response to heat
HB760_01930	COG0583	DNA-binding transcription factor activity
HB760_01935	COG2860	membrane
HB760_01960	COG0493	'glutamate synthase
HB760_01965	COG0067	glutamate synthase
HB760_01965	COG0069	glutamate synthase activity
HB760_01965	COG0070	glutamate synthase
HB760_01975	COG0067	glutamate synthase
HB760_01975	COG0069	glutamate synthase activity
HB760_01975	COG0070	glutamate synthase
HB760_01980	COG1242	4 iron, 4 sulfur cluster binding
HB760_01985	COG4251	negative regulation of phosphorylation
HB760_01985	COG5001	Diguanylate cyclase
HB760_01985	COG3706	GGDEF domain
HB760_01985	COG2203	Gaf domain
HB760_01990	COG0784	Response regulator, receiver
HB760_01990	COG2198	Histidine kinase
HB760_01990	COG5002	protein histidine kinase activity
HB760_02000	COG0745	RESPONSE REGULATOR receiver
HB760_02010	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HB760_02025	COG0083	homoserine kinase activity
HB760_02030	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HB760_02035	COG0431	NADPH-dependent FMN reductase
HB760_02060	COG1115	amino acid carrier protein
HB760_02065	COG3022	response to hydroperoxide
HB760_02075	COG0513	Belongs to the DEAD box helicase family
HB760_02090	COG0716	FMN binding
HB760_02095	COG4974	Belongs to the 'phage' integrase family
HB760_02100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB760_02105	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HB760_02130	COG0667	Aldo Keto reductase
HB760_02155	COG0730	response to heat
HB760_02170	COG1283	sodium-dependent phosphate transmembrane transporter activity
HB760_02175	COG0583	DNA-binding transcription factor activity
HB760_02180	COG0640	Transcriptional regulator
HB760_02185	COG0268	Binds directly to 16S ribosomal RNA
HB760_02190	COG0728	peptidoglycan biosynthetic process
HB760_02195	COG0196	riboflavin kinase activity
HB760_02210	COG1047	Peptidyl-prolyl cis-trans
HB760_02215	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HB760_02220	COG3279	Response regulator of the LytR AlgR family
HB760_02225	COG3275	phosphorelay sensor kinase activity
HB760_02230	COG1966	Carbon starvation protein
HB760_02250	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HB760_02260	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HB760_02265	COG1605	Chorismate mutase
HB760_02265	COG0287	Prephenate dehydrogenase
HB760_02270	COG0739	heme binding
HB760_02280	COG0488	(ABC) transporter
HB760_02295	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HB760_02300	COG1605	Chorismate mutase
HB760_02300	COG0077	Prephenate dehydratase
HB760_02305	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HB760_02310	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HB760_02315	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HB760_02320	COG0564	pseudouridine synthase activity
HB760_02325	COG1496	oxidoreductase activity
HB760_02330	COG0542	response to heat
HB760_02385	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HB760_02390	COG0826	peptidase U32
HB760_02400	COG0745	RESPONSE REGULATOR receiver
HB760_02405	COG5002	protein histidine kinase activity
HB760_02415	COG0248	Ppx GppA phosphatase
HB760_02420	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HB760_02425	COG0573	inorganic phosphate transmembrane transporter activity
HB760_02430	COG0581	inorganic phosphate transmembrane transporter activity
HB760_02435	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HB760_02440	COG0704	Plays a role in the regulation of phosphate uptake
HB760_02455	COG0450	alkyl hydroperoxide reductase
HB760_02460	COG0583	DNA-binding transcription factor activity
HB760_02465	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HB760_02475	COG0517	IMP dehydrogenase activity
HB760_02495	COG1862	Preprotein translocase
HB760_02500	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HB760_02505	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HB760_02510	COG0483	inositol monophosphate 1-phosphatase activity
HB760_02515	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HB760_02530	COG0822	iron-sulfur transferase activity
HB760_02535	COG0316	Belongs to the HesB IscA family
HB760_02550	COG0633	Ferredoxin
HB760_02555	COG2975	iron-sulfur cluster assembly
HB760_02590	COG2976	Protein conserved in bacteria
HB760_02595	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HB760_02610	COG2199	diguanylate cyclase activity
HB760_02610	COG2203	Gaf domain
HB760_02625	COG0516	GMP reductase activity
HB760_02625	COG0517	IMP dehydrogenase activity
HB760_02635	COG1757	Na H antiporter
HB760_02645	COG1584	GPR1 FUN34 yaaH family protein
HB760_02650	COG1115	amino acid carrier protein
HB760_02655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB760_02660	COG0583	DNA-binding transcription factor activity
HB760_02665	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HB760_02670	COG0668	transmembrane transport
HB760_02685	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HB760_02705	COG1289	transmembrane transporter activity
HB760_02710	COG0583	DNA-binding transcription factor activity
HB760_02725	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HB760_02805	COG0582	viral genome integration into host DNA
HB760_02820	COG2867	negative regulation of translational initiation
HB760_02825	COG2914	Belongs to the UPF0125 (RnfH) family
HB760_02830	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HB760_02835	COG0456	acetyltransferase
HB760_02840	COG0497	DNA recombination
HB760_02855	COG1301	dicarboxylic acid transport
HB760_02860	COG0443	Heat shock 70 kDa protein
HB760_02875	COG4969	Belongs to the N-Me-Phe pilin family
HB760_02895	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HB760_02900	COG0590	tRNA wobble adenosine to inosine editing
HB760_02910	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HB760_02910	COG0047	phosphoribosylformylglycinamidine synthase activity
HB760_02935	COG2195	Cleaves the N-terminal amino acid of tripeptides
HB760_02940	COG2252	PERMEase
HB760_02950	COG1073	alpha beta
HB760_02965	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HB760_02970	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HB760_02975	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HB760_02975	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HB760_03000	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HB760_03005	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HB760_03015	COG0142	geranyltranstransferase activity
HB760_03025	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HB760_03040	COG0583	DNA-binding transcription factor activity
HB760_03050	COG2363	Small membrane protein
HB760_03065	COG1611	Belongs to the LOG family
HB760_03090	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HB760_03105	COG1464	Belongs to the NlpA lipoprotein family
HB760_03110	COG2011	ABC-type metal ion transport system permease component
HB760_03115	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HB760_03120	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HB760_03130	COG1263	PTS System
HB760_03130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HB760_03135	COG0366	Alpha amylase catalytic
HB760_03140	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HB760_03145	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HB760_03165	COG1686	Belongs to the peptidase S11 family
HB760_03170	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HB760_03175	COG0772	Belongs to the SEDS family
HB760_03180	COG0768	penicillin binding
HB760_03190	COG0799	negative regulation of ribosome biogenesis
HB760_03195	COG1466	dna polymerase III delta subunit
HB760_03200	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HB760_03210	COG2888	peptidyl-tyrosine sulfation
HB760_03215	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HB760_03220	COG4535	Mg2 and Co2 transporter CorC
HB760_03230	COG1702	phosphate starvation-inducible protein PhoH
HB760_03240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB760_03360	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HB760_03385	COG2890	protein-(glutamine-N5) methyltransferase activity
HB760_03390	COG3094	Invasion gene expression up-regulator, SirB
HB760_03395	COG2912	Transglutaminase-like superfamily
HB760_03405	COG0737	Belongs to the 5'-nucleotidase family
HB760_03410	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HB760_03415	COG1187	pseudouridine synthase activity
HB760_03420	COG2840	Smr protein MutS2
HB760_03460	COG2217	Heavy metal translocating P-type atpase
HB760_03460	COG2608	mercury ion transmembrane transporter activity
HB760_03470	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HB760_03525	COG0835	chemotaxis
HB760_03525	COG0784	Response regulator, receiver
HB760_03530	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HB760_03535	COG1815	bacterial-type flagellum-dependent cell motility
HB760_03540	COG1558	bacterial-type flagellum-dependent cell motility
HB760_03550	COG1749	Flagellar hook protein flgE
HB760_03555	COG4787	bacterial-type flagellum-dependent cell motility
HB760_03565	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HB760_03570	COG1706	bacterial-type flagellum-dependent cell motility
HB760_03575	COG1705	Flagellar rod assembly protein muramidase FlgJ
HB760_03575	COG3951	Flagellar rod assembly protein muramidase FlgJ
HB760_03595	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HB760_03600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HB760_03605	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HB760_03610	COG2190	(PTS) system
HB760_03615	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HB760_03620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB760_03625	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HB760_03630	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HB760_03670	COG0330	HflC and HflK could
HB760_03675	COG3118	belongs to the thioredoxin family
HB760_03680	COG0300	oxidoreductase activity
HB760_03685	COG1090	epimerase
HB760_03695	COG0622	Phosphoesterase
HB760_03715	COG3710	Transcriptional regulator
HB760_03730	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HB760_03735	COG3104	oligopeptide transport
HB760_03740	COG0250	Participates in transcription elongation, termination and antitermination
HB760_03745	COG0367	asparagine synthase
HB760_03750	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HB760_03750	COG4651	solute:proton antiporter activity
HB760_03755	COG1940	carbohydrate kinase activity
HB760_03755	COG1846	Transcriptional regulator
HB760_03760	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HB760_03765	COG2190	(PTS) system
HB760_03765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HB760_03765	COG1263	PTS System
HB760_03775	COG2165	general secretion pathway protein
HB760_03780	COG0735	belongs to the Fur family
HB760_03800	COG0596	Alpha beta hydrolase
HB760_03805	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HB760_03810	COG0033	Phosphoglucomutase
HB760_03820	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HB760_03835	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HB760_03840	COG1053	succinate dehydrogenase
HB760_03850	COG0567	Dehydrogenase, E1 component
HB760_03855	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB760_03870	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HB760_03875	COG1121	(ABC) transporter
HB760_03880	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HB760_03885	COG4977	sequence-specific DNA binding
HB760_03890	COG1918	ferrous iron import across plasma membrane
HB760_03920	COG3102	Protein conserved in bacteria
HB760_03930	COG0788	formyltetrahydrofolate deformylase activity
HB760_03935	COG1199	ATP-dependent helicase activity
HB760_03940	COG1214	PFAM Peptidase M22, glycoprotease
HB760_03950	COG3065	identical protein binding
HB760_03955	COG2267	carboxylic ester hydrolase activity
HB760_03960	COG0318	PFAM AMP-dependent synthetase and ligase
HB760_03965	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HB760_03970	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HB760_03975	COG2894	cell division
HB760_03990	COG2951	lytic endotransglycosylase activity
HB760_04000	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HB760_04015	COG2226	methyltransferase
HB760_04025	COG1028	Short-chain dehydrogenase reductase Sdr
HB760_04035	COG1169	isochorismate synthase
HB760_04040	COG1021	2,3-dihydroxybenzoate-AMP ligase
HB760_04045	COG3433	isochorismatase activity
HB760_04045	COG1535	isochorismatase
HB760_04050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB760_04060	COG2977	Belongs to the P-Pant transferase superfamily
HB760_04065	COG4771	TonB-dependent receptor
HB760_04075	COG0513	Belongs to the DEAD box helicase family
HB760_04080	COG0569	domain protein
HB760_04085	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HB760_04105	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HB760_04110	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HB760_04115	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HB760_04150	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HB760_04155	COG0776	regulation of translation
HB760_04160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HB760_04165	COG1555	photosystem II stabilization
HB760_04185	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HB760_04190	COG0436	Aminotransferase
HB760_04195	COG1169	isochorismate synthase
HB760_04205	COG0596	Alpha beta hydrolase
HB760_04210	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HB760_04225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HB760_04225	COG1263	PTS System
HB760_04225	COG2190	(PTS) system
HB760_04230	COG0583	DNA-binding transcription factor activity
HB760_04240	COG2855	membrane
HB760_04295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB760_04315	COG1522	sequence-specific DNA binding
HB760_04320	COG1946	Acyl-CoA thioesterase
HB760_04325	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HB760_04340	COG3706	GGDEF domain
HB760_04400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HB760_04405	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HB760_04410	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HB760_04415	COG0517	IMP dehydrogenase activity
HB760_04415	COG0516	GMP reductase activity
HB760_04425	COG2217	Heavy metal translocating P-type atpase
HB760_04445	COG0537	adenosine 5'-monophosphoramidase activity
HB760_04475	COG1252	NADH dehydrogenase
HB760_04490	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HB760_04500	COG4591	ABC-type transport system involved in lipoprotein release permease component
HB760_04505	COG1136	(ABC) transporter
HB760_04510	COG4591	ABC-type transport system involved in lipoprotein release permease component
HB760_04520	COG0658	competence protein
HB760_04520	COG2333	competence protein COMEC
HB760_04525	COG1132	(ABC) transporter
HB760_04545	COG2719	SpoVR family
HB760_04550	COG2718	Belongs to the UPF0229 family
HB760_04555	COG2766	serine protein kinase
HB760_04570	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HB760_04580	COG1882	Formate acetyltransferase
HB760_04615	COG0708	Exodeoxyribonuclease III
HB760_04625	COG3923	Primosomal replication protein n
HB760_04630	COG0730	response to heat
HB760_04635	COG1199	ATP-dependent helicase activity
HB760_04645	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HB760_04650	COG1187	pseudouridine synthase activity
HB760_04660	COG1278	Cold shock
HB760_04670	COG0542	response to heat
HB760_04675	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HB760_04705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HB760_04710	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HB760_04715	COG0297	glycogen (starch) synthase activity
HB760_04735	COG3070	regulator of competence-specific genes
HB760_04750	COG0745	RESPONSE REGULATOR receiver
HB760_04755	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HB760_04760	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HB760_04770	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HB760_04775	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HB760_04795	COG4067	protein conserved in archaea
HB760_04795	COG0189	ligase activity
HB760_04810	COG1801	Protein of unknown function DUF72
HB760_04825	COG0840	transmembrane signaling receptor activity
HB760_04830	COG0632	four-way junction helicase activity
HB760_04840	COG1271	oxidase subunit
HB760_04845	COG1294	oxidase, subunit
HB760_04850	COG4890	Cyd operon protein YbgT
HB760_04860	COG0824	Thioesterase
HB760_04865	COG0811	peptide transport
HB760_04880	COG0823	Involved in the tonB-independent uptake of proteins
HB760_04885	COG2885	chlorophyll binding
HB760_04890	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HB760_04905	COG3766	membrane
HB760_04915	COG0754	glutathionylspermidine amidase activity
HB760_04925	COG0784	Response regulator, receiver
HB760_04925	COG2205	protein histidine kinase activity
HB760_04970	COG1104	cysteine desulfurase activity
HB760_04985	COG0482	sulfurtransferase activity
HB760_05005	COG0513	Belongs to the DEAD box helicase family
HB760_05080	COG4669	(LipO)protein
HB760_05110	COG3177	Filamentation induced by cAMP protein fic
HB760_05120	COG0583	DNA-binding transcription factor activity
HB760_05125	COG4792	protein secretion
HB760_05130	COG4791	protein targeting
HB760_05135	COG4794	Type iii secretion
HB760_05140	COG4790	Type iii secretion
HB760_05210	COG0457	Tetratricopeptide repeat
HB760_05230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HB760_05265	COG2824	Alkylphosphonate utilization operon protein PhnA
HB760_05275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB760_05280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB760_05295	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HB760_05315	COG3568	Endonuclease Exonuclease Phosphatase
HB760_05335	COG4934	collagen metabolic process
HB760_05340	COG0402	S-adenosylhomocysteine deaminase activity
HB760_05365	COG0583	DNA-binding transcription factor activity
HB760_05375	COG0686	Belongs to the AlaDH PNT family
HB760_05385	COG1674	ftsk spoiiie
HB760_05395	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HB760_05405	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HB760_05425	COG2226	methyltransferase
HB760_05450	COG0300	oxidoreductase activity
HB760_05465	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HB760_05485	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HB760_05505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HB760_05515	COG1757	Na H antiporter
HB760_05525	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HB760_05535	COG0131	Imidazoleglycerol-phosphate dehydratase
HB760_05535	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HB760_05540	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HB760_05555	COG0140	phosphoribosyl-ATP diphosphatase activity
HB760_05555	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HB760_05560	COG3012	SEC-C Motif Domain Protein
HB760_05565	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HB760_05570	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HB760_05575	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HB760_05580	COG0215	cysteine-tRNA ligase activity
HB760_05585	COG1435	thymidine kinase activity
HB760_05590	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HB760_05610	COG2116	formate transmembrane transporter activity
HB760_05620	COG0390	transport system, permease component
HB760_05625	COG4459	periplasmic nitrate reductase
HB760_05630	COG3005	denitrification pathway
HB760_05635	COG0243	molybdopterin cofactor binding
HB760_05650	COG1121	(ABC) transporter
HB760_05655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HB760_05660	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HB760_05665	COG1227	inorganic diphosphatase activity
HB760_05675	COG4172	Belongs to the ABC transporter superfamily
HB760_05685	COG4171	peptide transport system, permease
HB760_05690	COG4168	peptide transport system, permease
HB760_05700	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HB760_05705	COG1842	Phage shock protein A
HB760_05715	COG1983	PspC domain protein
HB760_05725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB760_05735	COG2818	Glycosylase
HB760_05755	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HB760_05760	COG0626	cystathionine gamma-synthase activity
HB760_05770	COG0733	neurotransmitter:sodium symporter activity
HB760_05775	COG0564	pseudouridine synthase activity
HB760_05790	COG2814	Major facilitator Superfamily
HB760_05800	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HB760_05805	COG4136	ATPase activity
HB760_05810	COG4135	transport system, permease component
HB760_05815	COG4134	Bacterial extracellular solute-binding protein
HB760_05825	COG0659	secondary active sulfate transmembrane transporter activity
HB760_05835	COG3313	Fe-S protein
HB760_05850	COG2310	stress, protein
HB760_05870	COG1358	cellular component organization or biogenesis
HB760_05930	COG1061	Type III restriction enzyme res subunit
HB760_05935	COG1187	pseudouridine synthase activity
HB760_05940	COG2814	Major facilitator Superfamily
HB760_05950	COG0702	epimerase
HB760_05955	COG0534	Mate efflux family protein
HB760_05960	COG4181	ATPase activity
HB760_05990	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HB760_06000	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HB760_06010	COG1737	Transcriptional regulator
HB760_06015	COG0076	glutamate decarboxylase activity
HB760_06025	COG2431	L-lysine efflux transmembrane transporter activity
HB760_06035	COG3070	regulator of competence-specific genes
HB760_06050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB760_06050	COG4191	Histidine kinase
HB760_06060	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HB760_06085	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HB760_06090	COG4988	ABC transporter
HB760_06095	COG0492	ferredoxin-NADP+ reductase activity
HB760_06100	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HB760_06120	COG0471	metal ion transport
HB760_06125	COG2949	membrane
HB760_06135	COG1643	Atp-dependent helicase
HB760_06195	COG0277	FAD linked oxidase domain protein
HB760_06195	COG0247	lactate metabolic process
HB760_06240	COG2986	histidine ammonia-lyase
HB760_06250	COG0010	Belongs to the arginase family
HB760_06260	COG2188	Transcriptional regulator
HB760_06305	COG0251	oxidation-reduction process
HB760_06355	COG0072	phenylalanine-tRNA ligase activity
HB760_06355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB760_06360	COG1535	isochorismatase
HB760_06360	COG3433	isochorismatase activity
HB760_06365	COG1132	(ABC) transporter
HB760_06380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB760_06400	COG4774	siderophore transport
HB760_06405	COG4607	ABC-type enterochelin transport system periplasmic component
HB760_06410	COG4605	iron ion homeostasis
HB760_06415	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HB760_06465	COG1346	cytolysis
HB760_06475	COG2925	Exonuclease
HB760_06485	COG1823	symporter activity
HB760_06495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB760_06505	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HB760_06515	COG2062	phosphohistidine phosphatase, SixA
HB760_06530	COG4139	cobalamin transport
HB760_06560	COG0583	DNA-binding transcription factor activity
HB760_06570	COG1451	nucleotide metabolic process
HB760_06625	COG1562	ergosterol biosynthetic process
HB760_06655	COG2195	Cleaves the N-terminal amino acid of tripeptides
HB760_06670	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HB760_06680	COG0625	glutathione transferase activity
HB760_06715	COG0515	serine threonine protein kinase
HB760_06715	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HB760_06720	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HB760_06800	COG0456	acetyltransferase
HB760_06840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HB760_06885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB760_06905	COG3290	protein histidine kinase activity
HB760_06910	COG4565	transcriptional regulatory protein
HB760_06915	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HB760_06920	COG0363	glucosamine-6-phosphate deaminase activity
HB760_06925	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HB760_06935	COG3284	Transcriptional regulator
HB760_06940	COG1012	belongs to the aldehyde dehydrogenase family
HB760_06945	COG2358	TRAP transporter, solute receptor (TAXI family
HB760_06955	COG0730	response to heat
HB760_07025	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HB760_07035	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HB760_07040	COG0372	Belongs to the citrate synthase family
HB760_07050	COG2828	Protein conserved in bacteria
HB760_07085	COG0561	phosphatase activity
HB760_07090	COG0602	queuosine metabolic process
HB760_07100	COG3706	GGDEF domain
HB760_07155	COG1254	Belongs to the acylphosphatase family
HB760_07160	COG2920	part of a sulfur-relay system
HB760_07165	COG0670	Belongs to the BI1 family
HB760_07170	COG1126	abc transporter atp-binding protein
HB760_07175	COG0765	amino acid transport
HB760_07180	COG4597	amino acid ABC transporter
HB760_07185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB760_07200	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HB760_07225	COG3008	intermembrane lipid transfer
HB760_07230	COG2995	paraquat-inducible protein a
HB760_07235	COG1132	(ABC) transporter
HB760_07240	COG1956	GAF domain-containing protein
HB760_07245	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HB760_07260	COG0308	aminopeptidase N
HB760_07270	COG2902	Dehydrogenase
HB760_07295	COG0488	(ABC) transporter
HB760_07315	COG1067	ATP-dependent peptidase activity
HB760_07345	COG2205	protein histidine kinase activity
HB760_07345	COG0784	Response regulator, receiver
HB760_07360	COG3278	Belongs to the heme-copper respiratory oxidase family
HB760_07375	COG2010	Cytochrome c
HB760_07385	COG2217	Heavy metal translocating P-type atpase
HB760_07400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB760_07405	COG0589	response to stress
HB760_07430	COG3842	ATPase activity
HB760_07440	COG1177	transmembrane transport
HB760_07450	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HB760_07455	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HB760_07470	COG0437	4 iron, 4 sulfur cluster binding
HB760_07475	COG0243	molybdopterin cofactor binding
HB760_07475	COG3383	formate dehydrogenase (NAD+) activity
HB760_07485	COG3381	protein complex oligomerization
HB760_07505	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HB760_07510	COG0488	(ABC) transporter
HB760_07525	COG4191	Histidine kinase
HB760_07530	COG2204	response regulator
HB760_07540	COG4662	Binding-protein-dependent transport system inner membrane component
HB760_07545	COG3842	ATPase activity
HB760_07555	COG0303	'Molybdopterin
HB760_07565	COG1940	carbohydrate kinase activity
HB760_07570	COG3148	PFAM DTW domain containing protein
HB760_07615	COG0840	transmembrane signaling receptor activity
HB760_07620	COG0791	NLP P60 protein
HB760_07630	COG3706	GGDEF domain
HB760_07635	COG2201	protein-glutamate methylesterase activity
HB760_07640	COG3001	Fructosamine kinase
HB760_07650	COG0307	riboflavin synthase, alpha
HB760_07655	COG0534	Mate efflux family protein
HB760_07665	COG1793	dna ligase
HB760_07675	COG2885	chlorophyll binding
HB760_07695	COG2204	response regulator
HB760_07700	COG0438	transferase activity, transferring glycosyl groups
HB760_07705	COG0438	transferase activity, transferring glycosyl groups
HB760_07735	COG0438	transferase activity, transferring glycosyl groups
HB760_07740	COG1215	transferase activity, transferring glycosyl groups
HB760_07745	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HB760_07770	COG5001	Diguanylate cyclase
HB760_07770	COG3300	MHYT domain
HB760_07775	COG2205	protein histidine kinase activity
HB760_07775	COG3437	response regulator, receiver
HB760_07775	COG3850	Histidine kinase
HB760_07775	COG4999	Histidine kinase
HB760_07800	COG2205	protein histidine kinase activity
HB760_07800	COG0784	Response regulator, receiver
HB760_07820	COG1846	Transcriptional regulator
HB760_07835	COG3247	response to pH
HB760_07840	COG0668	transmembrane transport
HB760_07855	COG0318	PFAM AMP-dependent synthetase and ligase
HB760_08015	COG0454	-acetyltransferase
HB760_08055	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HB760_08060	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HB760_08260	COG1404	Belongs to the peptidase S8 family
HB760_08265	COG1858	cytochrome C peroxidase
HB760_08280	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB760_08290	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HB760_08300	COG0215	cysteine-tRNA ligase activity
HB760_08315	COG1368	sulfuric ester hydrolase activity
HB760_08340	COG1115	amino acid carrier protein
HB760_08370	COG1280	lysine exporter protein (LysE YggA)
HB760_08380	COG1280	lysine exporter protein (LysE YggA)
HB760_08400	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HB760_08425	COG1280	lysine exporter protein (LysE YggA)
HB760_08465	COG3063	Type IV pilus biogenesis stability protein PilW
HB760_08490	COG1643	Atp-dependent helicase
HB760_08530	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HB760_08540	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HB760_08560	COG3227	Zinc metalloprotease (Elastase)
HB760_08590	COG3706	GGDEF domain
HB760_08600	COG0443	Heat shock 70 kDa protein
HB760_08605	COG0443	Heat shock 70 kDa protein
HB760_08620	COG2165	general secretion pathway protein
HB760_08625	COG1132	(ABC) transporter
HB760_08630	COG1132	(ABC) transporter
HB760_08650	COG0814	amino acid
HB760_08660	COG4221	oxidoreductase activity
HB760_08665	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HB760_08675	COG0861	Integral membrane protein TerC family
HB760_08685	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HB760_08690	COG1328	CTP reductase activity
HB760_08715	COG0456	acetyltransferase
HB760_08740	COG3340	Belongs to the peptidase S51 family
HB760_08800	COG2801	Transposase and inactivated derivatives
HB760_08865	COG3152	Membrane
HB760_08965	COG1335	isochorismatase
HB760_09120	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HB760_09120	COG0517	IMP dehydrogenase activity
HB760_09145	COG1335	isochorismatase
HB760_09190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HB760_09205	COG3106	COG3106 Predicted ATPase
HB760_09220	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HB760_09225	COG0784	Response regulator, receiver
HB760_09225	COG2205	protein histidine kinase activity
HB760_09240	COG0814	amino acid
HB760_09245	COG1760	l-serine dehydratase
HB760_09250	COG5001	Diguanylate cyclase
HB760_09250	COG3300	MHYT domain
HB760_09265	COG2197	response regulator
HB760_09270	COG0720	synthase
HB760_09280	COG0017	Asparaginyl-tRNA synthetase
HB760_09295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB760_09315	COG1448	Aminotransferase
HB760_09335	COG0840	transmembrane signaling receptor activity
HB760_09340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB760_09345	COG1846	Transcriptional regulator
HB760_09370	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HB760_09385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB760_09390	COG3108	Peptidase M15
HB760_09395	COG2989	Protein conserved in bacteria
HB760_09430	COG4235	cytochrome complex assembly
HB760_09430	COG3088	subunit of a heme lyase
HB760_09470	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HB760_09475	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HB760_09485	COG1058	Belongs to the CinA family
HB760_09485	COG1546	Belongs to the CinA family
HB760_09500	COG0019	diaminopimelate decarboxylase activity
HB760_09540	COG0322	excinuclease ABC activity
HB760_09545	COG2197	response regulator
HB760_09550	COG0417	DNA replication proofreading
HB760_09570	COG1187	pseudouridine synthase activity
HB760_09580	COG0009	L-threonylcarbamoyladenylate synthase
HB760_09585	COG0613	PHP domain protein
HB760_09595	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HB760_09600	COG0512	Glutamine amidotransferase of anthranilate synthase
HB760_09610	COG0134	indole-3-glycerol-phosphate synthase activity
HB760_09610	COG0135	phosphoribosylanthranilate isomerase activity
HB760_09620	COG0159	tryptophan synthase activity
HB760_09625	COG1301	dicarboxylic acid transport
HB760_09650	COG2350	Protein conserved in bacteria
HB760_09680	COG1716	ATPase activity
HB760_09680	COG5001	Diguanylate cyclase
HB760_09685	COG1032	radical SAM domain protein
HB760_09780	COG2175	clavaminate synthase activity
HB760_09785	COG0840	transmembrane signaling receptor activity
HB760_09795	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HB760_09800	COG0463	Glycosyl transferase, family 2
HB760_09805	COG0745	RESPONSE REGULATOR receiver
HB760_09810	COG5002	protein histidine kinase activity
HB760_09810	COG3850	Histidine kinase
HB760_09870	COG3615	Tellurite resistance protein tehB
HB760_09880	COG2207	Transcriptional regulator
HB760_09880	COG3708	Transcriptional regulator
HB760_09890	COG1217	gtp-binding protein TYPA
HB760_09925	COG2176	DNA-directed DNA polymerase activity
HB760_09940	COG1136	(ABC) transporter
HB760_09940	COG0577	efflux transmembrane transporter activity
HB760_09945	COG0577	efflux transmembrane transporter activity
HB760_09945	COG1136	(ABC) transporter
HB760_09950	COG0577	efflux transmembrane transporter activity
HB760_09960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB760_09975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HB760_09985	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HB760_09995	COG3118	belongs to the thioredoxin family
HB760_10000	COG4232	protein-disulfide reductase activity
HB760_10015	COG2995	paraquat-inducible protein a
HB760_10020	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HB760_10020	COG3008	intermembrane lipid transfer
HB760_10025	COG3009	Protein conserved in bacteria
HB760_10040	COG4166	transmembrane transport
HB760_10050	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HB760_10055	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HB760_10065	COG0539	negative regulation of cytoplasmic translation
HB760_10075	COG0616	signal peptide processing
HB760_10080	COG1028	Short-chain dehydrogenase reductase Sdr
HB760_10100	COG0835	chemotaxis
HB760_10100	COG0784	Response regulator, receiver
HB760_10105	COG1940	carbohydrate kinase activity
HB760_10120	COG3710	Transcriptional regulator
HB760_10125	COG2272	Belongs to the type-B carboxylesterase lipase family
HB760_10155	COG4667	esterase of the alpha-beta hydrolase superfamily
HB760_10170	COG0733	neurotransmitter:sodium symporter activity
HB760_10185	COG1263	PTS System
HB760_10185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HB760_10190	COG0084	hydrolase, TatD family'
HB760_10205	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HB760_10235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HB760_10250	COG1399	metal-binding, possibly nucleic acid-binding protein
HB760_10255	COG0424	maF-like protein
HB760_10260	COG0564	pseudouridine synthase activity
HB760_10265	COG1530	ribonuclease E activity
HB760_10270	COG0659	secondary active sulfate transmembrane transporter activity
HB760_10275	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HB760_10280	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HB760_10310	COG2186	Transcriptional regulator
HB760_10320	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HB760_10325	COG0653	protein targeting
HB760_10330	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HB760_10340	COG0366	Alpha amylase catalytic
HB760_10345	COG1122	ATPase activity
HB760_10350	COG4120	Belongs to the binding-protein-dependent transport system permease family
HB760_10370	COG0857	belongs to the CobB CobQ family
HB760_10370	COG0280	phosphate acetyltransferase
HB760_10375	COG0435	Glutathione S-transferase
HB760_10385	COG0444	Belongs to the ABC transporter superfamily
HB760_10390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB760_10395	COG0601	transmembrane transport
HB760_10405	COG0314	molybdopterin synthase activity
HB760_10410	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HB760_10420	COG0521	Mo-molybdopterin cofactor biosynthetic process
HB760_10425	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HB760_10430	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HB760_10445	COG0556	nucleotide-excision repair
HB760_10505	COG4657	Part of a membrane complex involved in electron transport
HB760_10515	COG4656	Part of a membrane complex involved in electron transport
HB760_10520	COG4658	electron transport chain
HB760_10525	COG4659	FMN binding
HB760_10530	COG4660	Part of a membrane complex involved in electron transport
HB760_10535	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HB760_10540	COG0346	lactoylglutathione lyase activity
HB760_10550	COG2885	chlorophyll binding
HB760_10560	COG2056	Na+-H+ antiporter family
HB760_10575	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HB760_10590	COG1028	Short-chain dehydrogenase reductase Sdr
HB760_10595	COG1012	belongs to the aldehyde dehydrogenase family
HB760_10595	COG1454	alcohol dehydrogenase
HB760_10600	COG2095	MarC family integral membrane protein
HB760_10605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB760_10610	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HB760_10615	COG1757	Na H antiporter
HB760_10640	COG3083	sulfuric ester hydrolase activity
HB760_10655	COG4269	membrane
HB760_10665	COG0123	including yeast histone deacetylase and acetoin utilization protein
HB760_10680	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HB760_10685	COG0778	Nitroreductase
HB760_10690	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB760_10690	COG1902	pentaerythritol trinitrate reductase activity
HB760_10695	COG0616	signal peptide processing
HB760_10700	COG0252	asparaginase activity
HB760_10705	COG3139	Protein of unknown function (DUF1315)
HB760_10715	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HB760_10720	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HB760_10740	COG2226	methyltransferase
HB760_10760	COG1785	Belongs to the alkaline phosphatase family
HB760_10770	COG0346	lactoylglutathione lyase activity
HB760_10780	COG0668	transmembrane transport
HB760_10785	COG0076	glutamate decarboxylase activity
HB760_10790	COG2985	domain, Protein
HB760_10795	COG2261	transglycosylase associated protein
HB760_10800	COG2983	Belongs to the UPF0260 family
HB760_10810	COG2964	Protein conserved in bacteria
HB760_10820	COG0251	oxidation-reduction process
HB760_10825	COG0814	amino acid
HB760_10830	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HB760_10835	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HB760_10845	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HB760_10855	COG2832	Protein of unknown function (DUF454)
HB760_10860	COG0745	RESPONSE REGULATOR receiver
HB760_10865	COG0583	DNA-binding transcription factor activity
HB760_10870	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HB760_10875	COG1286	toxin biosynthetic process
HB760_10880	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HB760_10885	COG0285	dihydrofolate synthase activity
HB760_10905	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HB760_10910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HB760_10915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HB760_10935	COG3101	peptidyl-lysine hydroxylation
HB760_10940	COG2860	membrane
HB760_10955	COG2890	protein-(glutamine-N5) methyltransferase activity
HB760_10965	COG2062	phosphohistidine phosphatase, SixA
HB760_10980	COG0183	Belongs to the thiolase family
HB760_10995	COG2067	long-chain fatty acid transport protein
HB760_11000	COG2067	long-chain fatty acid transport protein
HB760_11005	COG2853	Lipoprotein
HB760_11010	COG3088	subunit of a heme lyase
HB760_11010	COG4235	cytochrome complex assembly
HB760_11020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HB760_11025	COG1138	Cytochrome C-type biogenesis protein
HB760_11040	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HB760_11045	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HB760_11050	COG4133	protoheme IX ABC transporter activity
HB760_11060	COG0835	chemotaxis
HB760_11070	COG1192	Involved in chromosome partitioning
HB760_11075	COG2201	protein-glutamate methylesterase activity
HB760_11080	COG2198	Histidine kinase
HB760_11080	COG0643	Histidine kinase
HB760_11080	COG0784	Response regulator, receiver
HB760_11085	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HB760_11120	COG1684	flagellar biosynthetic protein fliR
HB760_11125	COG1987	bacterial-type flagellum assembly
HB760_11180	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HB760_11190	COG1677	Flagellar hook-basal body complex protein FliE
HB760_11210	COG1516	flagellar protein fliS
HB760_11220	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HB760_11225	COG1334	flagellar protein FlaG
HB760_11230	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HB760_11235	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HB760_11240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HB760_11260	COG2837	iron assimilation
HB760_11285	COG1393	Belongs to the ArsC family
HB760_11305	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HB760_11310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB760_11315	COG2716	regulation of RNA biosynthetic process
HB760_11320	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HB760_11335	COG4783	chaperone-mediated protein folding
HB760_11340	COG1393	Belongs to the ArsC family
HB760_11360	COG2233	PERMEase
HB760_11365	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HB760_11370	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HB760_11375	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HB760_11380	COG0121	glutamine amidotransferase
HB760_11385	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HB760_11390	COG1960	acyl-CoA dehydrogenase activity
HB760_11415	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB760_11425	COG2226	methyltransferase
HB760_11435	COG0741	lytic transglycosylase activity
HB760_11435	COG1388	LysM domain
HB760_11450	COG0347	Belongs to the P(II) protein family
HB760_11470	COG0587	DNA-directed DNA polymerase activity
HB760_11495	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HB760_11500	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HB760_11510	COG0750	zinc metalloprotease
HB760_11520	COG0575	Belongs to the CDS family
HB760_11525	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HB760_11550	COG0024	Methionine aminopeptidase
HB760_11565	COG0564	pseudouridine synthase activity
HB760_11570	COG3098	single-species biofilm formation
HB760_11600	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HB760_11615	COG1720	tRNA m6t6A37 methyltransferase activity
HB760_11640	COG0733	neurotransmitter:sodium symporter activity
HB760_11655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HB760_11660	COG0514	ATP-dependent DNA helicase (RecQ)
HB760_11665	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HB760_11680	COG1477	protein flavinylation
HB760_11690	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HB760_11695	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HB760_11705	COG1805	sodium ion transport
HB760_11710	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HB760_11715	COG0271	Belongs to the BolA IbaG family
HB760_11745	COG1595	DNA-templated transcription, initiation
HB760_11760	COG3248	Nucleoside-binding outer membrane protein
HB760_11765	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HB760_11770	COG0693	protein deglycase activity
HB760_11775	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HB760_11780	COG2166	iron-sulfur cluster assembly
HB760_11785	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HB760_11790	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HB760_11800	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HB760_11800	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HB760_11810	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HB760_11815	COG1074	ATP-dependent DNA helicase activity
HB760_11820	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HB760_11845	COG3141	response to X-ray
HB760_11860	COG2171	N-acyltransferase activity
HB760_11865	COG0584	glycerophosphoryl diester phosphodiesterase
HB760_11870	COG2271	Major facilitator Superfamily
HB760_11875	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HB760_11885	COG1349	DNA-binding transcription factor activity
HB760_11890	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HB760_11905	COG0741	lytic transglycosylase activity
HB760_11920	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB760_11925	COG0768	penicillin binding
HB760_11930	COG1609	Transcriptional regulator
HB760_11935	COG0583	DNA-binding transcription factor activity
HB760_11950	COG1022	Amp-dependent synthetase and ligase
HB760_11980	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HB760_11985	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HB760_11995	COG0560	Phosphoserine phosphatase
HB760_12005	COG0813	purine-nucleoside phosphorylase activity
HB760_12015	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HB760_12025	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HB760_12030	COG0084	hydrolase, TatD family'
HB760_12060	COG3153	acetyltransferase
HB760_12065	COG3154	lipid carrier protein
HB760_12075	COG0826	peptidase U32
HB760_12080	COG0826	peptidase U32
HB760_12085	COG0534	Mate efflux family protein
HB760_12130	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HB760_12150	COG0195	Participates in both transcription termination and antitermination
HB760_12170	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HB760_12180	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HB760_12185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HB760_12195	COG1534	Rna-binding protein
HB760_12200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HB760_12205	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HB760_12210	COG2027	D-alanyl-D-alanine carboxypeptidase
HB760_12225	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HB760_12230	COG0739	heme binding
HB760_12235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB760_12255	COG0628	permease
HB760_12265	COG2198	Histidine kinase
HB760_12265	COG0784	Response regulator, receiver
HB760_12265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB760_12265	COG2205	protein histidine kinase activity
HB760_12270	COG0747	negative chemotaxis
HB760_12280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB760_12285	COG0444	Belongs to the ABC transporter superfamily
HB760_12290	COG4608	Belongs to the ABC transporter superfamily
HB760_12300	COG2971	BadF BadG BcrA BcrD
HB760_12315	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB760_12320	COG3842	ATPase activity
HB760_12330	COG1840	ABC-type Fe3 transport system, periplasmic component
HB760_12335	COG0004	ammonium transporteR
HB760_12350	COG1049	propionate catabolic process, 2-methylcitrate cycle
HB760_12355	COG1752	Esterase of the alpha-beta hydrolase superfamily
HB760_12360	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HB760_12365	COG1643	Atp-dependent helicase
HB760_12380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HB760_12390	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HB760_12405	COG1560	Kdo2-lipid A biosynthetic process
HB760_12410	COG0842	Transport permease protein
HB760_12415	COG1131	(ABC) transporter
HB760_12420	COG0659	secondary active sulfate transmembrane transporter activity
HB760_12425	COG0288	reversible hydration of carbon dioxide
HB760_12440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB760_12445	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB760_12450	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HB760_12455	COG2186	Transcriptional regulator
HB760_12475	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HB760_12480	COG1459	type II secretion system
HB760_12490	COG0237	dephospho-CoA kinase activity
HB760_12495	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HB760_12500	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HB760_12520	COG0228	four-way junction DNA binding
HB760_12525	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HB760_12530	COG4137	Cytochrome C assembly protein
HB760_12535	COG4536	flavin adenine dinucleotide binding
HB760_12555	COG0612	Peptidase, M16
HB760_12560	COG1238	metal cluster binding
HB760_12570	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HB760_12575	COG5016	pyruvate
HB760_12575	COG0511	ligase activity, forming carbon-carbon bonds
HB760_12580	COG3630	sodium ion export across plasma membrane
HB760_12670	COG0527	aspartate kinase activity
HB760_12685	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HB760_12690	COG1546	Belongs to the CinA family
HB760_12700	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HB760_12730	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HB760_12740	COG0148	phosphopyruvate hydratase activity
HB760_12750	COG3956	TIGRFAM MazG family protein
HB760_12755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HB760_12775	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HB760_12780	COG1381	Involved in DNA repair and RecF pathway recombination
HB760_12785	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HB760_12805	COG3086	response to oxidative stress
HB760_12820	COG1595	DNA-templated transcription, initiation
HB760_12825	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HB760_12835	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HB760_12855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB760_12860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB760_12870	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HB760_12880	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HB760_12890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HB760_12900	COG0583	DNA-binding transcription factor activity
HB760_12915	COG0668	transmembrane transport
HB760_12920	COG0191	fructose-bisphosphate aldolase activity
HB760_12940	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HB760_12960	COG2356	endonuclease I
HB760_12965	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HB760_12970	COG0189	ligase activity
HB760_12975	COG1678	Uncharacterized ACR, COG1678
HB760_12980	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HB760_12995	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HB760_13000	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HB760_13005	COG0762	integral membrane protein
HB760_13020	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HB760_13025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HB760_13125	COG1012	belongs to the aldehyde dehydrogenase family
HB760_13175	COG1609	Transcriptional regulator
HB760_13185	COG1486	melibiose metabolic process
HB760_13190	COG1447	Phosphotransferase system cellobiose-specific component IIA
HB760_13205	COG0726	polysaccharide deacetylase
HB760_13215	COG1028	Short-chain dehydrogenase reductase Sdr
HB760_13225	COG0795	lipopolysaccharide-transporting ATPase activity
HB760_13230	COG0795	lipopolysaccharide-transporting ATPase activity
HB760_13240	COG2927	DNA polymerase III (CHI subunit)
HB760_13245	COG0525	valine-tRNA ligase activity
HB760_13255	COG0456	acetyltransferase
HB760_13295	COG0251	oxidation-reduction process
HB760_13300	COG0204	Acyl-transferase
HB760_13310	COG5007	Belongs to the BolA IbaG family
HB760_13320	COG2854	intermembrane phospholipid transfer
HB760_13325	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HB760_13330	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HB760_13335	COG1127	ABC transporter
HB760_13345	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HB760_13345	COG0517	IMP dehydrogenase activity
HB760_13355	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HB760_13360	COG1137	ATPase activity
HB760_13370	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HB760_13375	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB760_13385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB760_13390	COG2239	Acts as a magnesium transporter
HB760_13395	COG0312	modulator of DNA gyrase
HB760_13405	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HB760_13410	COG0564	pseudouridine synthase activity
HB760_13425	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HB760_13430	COG0312	modulator of DNA gyrase
HB760_13435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HB760_13440	COG3164	Protein of unknown function
HB760_13450	COG0424	maF-like protein
HB760_13455	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HB760_13460	COG1792	Involved in formation and maintenance of cell shape
HB760_13465	COG1077	Cell shape determining protein MreB Mrl
HB760_13500	COG2165	general secretion pathway protein
HB760_13510	COG1459	type II secretion system
HB760_13515	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HB760_13525	COG3267	Type II secretory pathway component ExeA
HB760_13525	COG3409	Peptidoglycan-binding domain 1 protein
HB760_13550	COG2200	EAL domain
HB760_13550	COG2199	diguanylate cyclase activity
HB760_13555	COG0629	single-stranded DNA binding
HB760_13570	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HB760_13580	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HB760_13585	COG0527	aspartate kinase activity
HB760_13590	COG1410	methionine synthase
HB760_13590	COG0646	methionine synthase
HB760_13655	COG3710	Transcriptional regulator
HB760_13660	COG0789	Transcriptional regulator
HB760_13670	COG0151	Belongs to the GarS family
HB760_13685	COG1253	flavin adenine dinucleotide binding
HB760_13690	COG3068	Protein conserved in bacteria
HB760_13700	COG1573	uracil-dna glycosylase
HB760_13710	COG2816	NAD+ diphosphatase activity
HB760_13715	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HB760_13735	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HB760_13750	COG0250	Participates in transcription elongation, termination and antitermination
HB760_13755	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HB760_13795	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HB760_13805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HB760_13885	COG4206	TonB-dependent receptor
HB760_13905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB760_13910	COG0534	Mate efflux family protein
HB760_13925	COG2937	Belongs to the GPAT DAPAT family
HB760_13935	COG3161	chorismate lyase activity
HB760_13940	COG1580	Controls the rotational direction of flagella during chemotaxis
HB760_13945	COG0705	Rhomboid family
HB760_13960	COG2177	Part of the ABC transporter FtsEX involved in
HB760_13965	COG2884	Cell division ATP-binding protein ftsE
HB760_13970	COG0552	protein localization to endoplasmic reticulum
HB760_13975	COG0742	ribosomal rna small subunit methyltransferase
HB760_13985	COG2095	MarC family integral membrane protein
HB760_14030	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HB760_14035	COG0640	Transcriptional regulator
HB760_14040	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HB760_14045	COG1280	lysine exporter protein (LysE YggA)
HB760_14050	COG2267	carboxylic ester hydrolase activity
HB760_14055	COG0561	phosphatase activity
HB760_14070	COG3148	PFAM DTW domain containing protein
HB760_14075	COG2199	diguanylate cyclase activity
HB760_14075	COG2200	EAL domain
HB760_14075	COG3287	FIST C domain
HB760_14080	COG1011	Hydrolase
HB760_14100	COG0019	diaminopimelate decarboxylase activity
HB760_14115	COG3072	Adenylate cyclase
HB760_14125	COG1587	Uroporphyrinogen-III synthase
HB760_14130	COG2959	enzyme of heme biosynthesis
HB760_14135	COG3071	HemY protein
HB760_14175	COG0633	Ferredoxin
HB760_14180	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HB760_14195	COG3118	belongs to the thioredoxin family
HB760_14210	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HB760_14220	COG0514	ATP-dependent DNA helicase (RecQ)
HB760_14225	COG2962	Rard protein
HB760_14235	COG1280	lysine exporter protein (LysE YggA)
HB760_14240	COG0405	Gamma-glutamyltransferase
HB760_14245	COG0210	DNA helicase
HB760_14255	COG3220	belongs to the UPF0276 family
HB760_14285	COG0006	proline dipeptidase activity
HB760_14285	COG0006	proline dipeptidase activity
HB760_14300	COG2104	thiamine diphosphate biosynthetic process
HB760_14305	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HB760_14325	COG2132	Multicopper oxidase
HB760_14370	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HB760_14375	COG1739	Uncharacterized protein family UPF0029
HB760_14385	COG0183	Belongs to the thiolase family
HB760_14390	COG0604	alcohol dehydrogenase
HB760_14415	COG2119	membrane
HB760_14430	COG3977	Valine--pyruvate aminotransferase
HB760_14435	COG0071	Belongs to the small heat shock protein (HSP20) family
HB760_14440	COG0187	DNA topoisomerase II activity
HB760_14450	COG0592	DNA-directed DNA polymerase activity
HB760_14470	COG1126	abc transporter atp-binding protein
HB760_14500	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HB760_14515	COG1192	Involved in chromosome partitioning
HB760_14520	COG1475	DNA binding
HB760_14525	COG3312	ion transport
HB760_14555	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HB760_14565	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HB760_14575	COG0765	amino acid transport
HB760_14580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB760_14585	COG2814	Major facilitator Superfamily
HB760_14590	COG0583	DNA-binding transcription factor activity
HB760_14600	COG0129	dihydroxy-acid dehydratase activity
HB760_14605	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HB760_14610	COG3978	acetolactate synthase activity
HB760_14620	COG0606	chelatase, subunit chli
HB760_14625	COG2199	diguanylate cyclase activity
HB760_14635	COG0204	Acyl-transferase
HB760_14640	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB760_14645	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HB760_14655	COG3084	Protein conserved in bacteria
HB760_14665	COG4326	sporulation control protein
HB760_14670	COG1272	protein, Hemolysin III
HB760_14680	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HB760_14685	COG0569	domain protein
HB760_14690	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HB760_14690	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HB760_14700	COG0242	peptide deformylase activity
HB760_14710	COG0758	DNA mediated transformation
HB760_14720	COG0551	DNA topoisomerase type I activity
HB760_14725	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HB760_14730	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HB760_14755	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HB760_14835	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HB760_14855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HB760_14860	COG0735	belongs to the Fur family
HB760_14875	COG0432	Pfam Uncharacterised protein family UPF0047
HB760_14885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HB760_14890	COG0305	Participates in initiation and elongation during chromosome replication
HB760_14910	COG2965	DNA replication, synthesis of RNA primer
HB760_14920	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HB760_14925	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HB760_14970	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HB760_14980	COG0678	peroxiredoxin activity
HB760_14980	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HB760_14985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB760_14995	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HB760_14995	COG0165	Argininosuccinate lyase
HB760_15010	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HB760_15020	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HB760_15030	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HB760_15035	COG0527	aspartate kinase activity
HB760_15035	COG0460	homoserine dehydrogenase
HB760_15040	COG0626	cystathionine gamma-synthase activity
HB760_15050	COG0281	malic enzyme
HB760_15060	COG2906	2 iron, 2 sulfur cluster binding
HB760_15070	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HB760_15085	COG2168	tRNA wobble position uridine thiolation
HB760_15090	COG2923	Belongs to the DsrF TusC family
HB760_15095	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HB760_15100	COG2964	Protein conserved in bacteria
HB760_15105	COG0545	Peptidyl-prolyl cis-trans isomerase
HB760_15120	COG1446	asparaginase
HB760_15125	COG1047	Peptidyl-prolyl cis-trans
HB760_15140	COG2249	NAD(P)H dehydrogenase (quinone) activity
HB760_15145	COG0488	(ABC) transporter
HB760_15155	COG0429	hydrolase of the alpha beta-hydrolase fold
HB760_15165	COG3954	Phosphoribulokinase
HB760_15170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB760_15190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HB760_15195	COG0512	Glutamine amidotransferase of anthranilate synthase
HB760_15215	COG0546	phosphoglycolate phosphatase activity
HB760_15220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HB760_15225	COG0557	exoribonuclease II activity
HB760_15235	COG1017	nitric oxide dioxygenase activity
HB760_15235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB760_15240	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HB760_15245	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HB760_15250	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HB760_15255	COG0330	HflC and HflK could
HB760_15260	COG0330	HflC and HflK could
HB760_15265	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HB760_15280	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HB760_15285	COG0860	N-Acetylmuramoyl-L-alanine amidase
HB760_15290	COG0802	atpase or kinase
HB760_15295	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HB760_15375	COG1162	GTPase activity
HB760_15385	COG0471	metal ion transport
HB760_15390	COG0840	transmembrane signaling receptor activity
HB760_15400	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HB760_15405	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HB760_15420	COG1045	serine acetyltransferase
HB760_15425	COG4942	peptidase
HB760_15450	COG1053	succinate dehydrogenase
HB760_15455	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HB760_15485	COG1509	lysine 2,3-aminomutase activity
HB760_15515	COG0534	Mate efflux family protein
HB760_15525	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HB760_15535	COG0745	RESPONSE REGULATOR receiver
HB760_15540	COG2205	protein histidine kinase activity
HB760_15550	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HB760_15555	COG3030	protein affecting phage T7 exclusion by the F plasmid
HB760_15560	COG1027	Aspartate ammonia-lyase
HB760_15565	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HB760_15570	COG4232	protein-disulfide reductase activity
HB760_15580	COG2095	MarC family integral membrane protein
HB760_15590	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HB760_15610	COG2198	Histidine kinase
HB760_15610	COG2205	protein histidine kinase activity
HB760_15610	COG0784	Response regulator, receiver
HB760_15615	COG2814	Major facilitator Superfamily
HB760_15630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB760_15635	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HB760_15640	COG0511	ligase activity, forming carbon-carbon bonds
HB760_15645	COG0439	Biotin carboxylase
HB760_15655	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HB760_15660	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HB760_15665	COG2199	diguanylate cyclase activity
HB760_15725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HB760_15730	COG1879	ABC-type sugar transport system periplasmic component
HB760_15735	COG1172	Belongs to the binding-protein-dependent transport system permease family
HB760_15740	COG1129	ABC transporter
HB760_15750	COG5001	Diguanylate cyclase
HB760_15810	COG2205	protein histidine kinase activity
HB760_15810	COG0784	Response regulator, receiver
HB760_15840	COG0330	HflC and HflK could
HB760_15850	COG0517	IMP dehydrogenase activity
HB760_15850	COG4175	Glycine betaine
HB760_15855	COG4176	ABC-type proline glycine betaine transport system permease component
HB760_15890	COG2885	chlorophyll binding
HB760_15930	COG0455	bacterial-type flagellum organization
HB760_15940	COG4964	Belongs to the GSP D family
HB760_15960	COG0583	DNA-binding transcription factor activity
HB760_16010	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HB760_16010	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HB760_16025	COG4989	oxidoreductase activity
HB760_16055	COG0303	'Molybdopterin
HB760_16060	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HB760_16095	COG2897	thiosulfate sulfurtransferase activity
HB760_16115	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HB760_16120	COG0840	transmembrane signaling receptor activity
HB760_16130	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HB760_16145	COG1612	heme a metabolic process
HB760_16170	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HB760_16185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB760_16195	COG1280	lysine exporter protein (LysE YggA)
HB760_16215	COG0179	Fumarylacetoacetate (FAA) hydrolase
HB760_16230	COG0697	spore germination
HB760_16245	COG2814	Major facilitator Superfamily
HB760_16250	COG0583	DNA-binding transcription factor activity
HB760_16280	COG1120	ATPase activity
HB760_16285	COG5001	Diguanylate cyclase
HB760_16290	COG0739	heme binding
HB760_16310	COG3314	Sporulation integral membrane protein YlbJ
HB760_16325	COG0814	amino acid
HB760_16360	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HB760_16365	COG1120	ATPase activity
HB760_16370	COG2814	Major facilitator Superfamily
HB760_16390	COG0798	PFAM Bile acid sodium symporter
HB760_16405	COG1881	PFAM PEBP family protein
HB760_16415	COG0251	oxidation-reduction process
HB760_16420	COG2706	6-phosphogluconolactonase activity
HB760_16430	COG0800	Aldolase
HB760_16435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HB760_16450	COG1131	(ABC) transporter
HB760_16455	COG0842	Transport permease protein
HB760_16490	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB760_16500	COG1280	lysine exporter protein (LysE YggA)
HB760_16505	COG0583	DNA-binding transcription factor activity
HB760_16520	COG0494	nUDIX hydrolase
HB760_16535	COG1858	cytochrome C peroxidase
HB760_16565	COG1505	serine-type exopeptidase activity
HB760_16570	COG0488	(ABC) transporter
HB760_16580	COG0589	response to stress
HB760_16590	COG0584	glycerophosphoryl diester phosphodiesterase
HB760_16600	COG1175	transmembrane transport
HB760_16605	COG0395	ABC-type sugar transport system, permease component
HB760_16610	COG3842	ATPase activity
HB760_16635	COG0523	cobalamin synthesis protein
HB760_16645	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HB760_16655	COG4667	esterase of the alpha-beta hydrolase superfamily
HB760_16660	COG1741	Belongs to the pirin family
HB760_16665	COG1278	Cold shock
HB760_16680	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HB760_16690	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HB760_16700	COG1686	Belongs to the peptidase S11 family
HB760_16705	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB760_16710	COG0625	glutathione transferase activity
HB760_16765	COG1764	response to oxidative stress
HB760_16770	COG2084	Dehydrogenase
HB760_16775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB760_16780	COG0823	Involved in the tonB-independent uptake of proteins
HB760_16795	COG1028	Short-chain dehydrogenase reductase Sdr
HB760_16800	COG3483	tryptophan 2,3-dioxygenase activity
HB760_16830	COG0583	DNA-binding transcription factor activity
HB760_16900	COG1683	Conserved Protein
HB760_16955	COG2801	Transposase and inactivated derivatives
HB760_16970	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HB760_16995	COG0625	glutathione transferase activity
HB760_17205	COG0456	acetyltransferase
HB760_17275	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HB760_17275	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HB760_17295	COG1028	Short-chain dehydrogenase reductase Sdr
HB760_17320	COG3746	phosphate-selective porin O and P
HB760_17340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB760_17380	COG0513	Belongs to the DEAD box helicase family
HB760_17410	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HB760_17415	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HB760_17420	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HB760_17425	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HB760_17430	COG0515	serine threonine protein kinase
HB760_17430	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HB760_17475	COG3675	Pfam Lipase (class 3)
HB760_17485	COG0583	DNA-binding transcription factor activity
HB760_17510	COG3853	Toxic anion resistance protein (TelA)
HB760_17520	COG2255	four-way junction helicase activity
HB760_17535	COG3122	Protein conserved in bacteria
HB760_17540	COG2321	neutral zinc metallopeptidase
HB760_17550	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HB760_17555	COG1215	transferase activity, transferring glycosyl groups
HB760_17565	COG0583	DNA-binding transcription factor activity
HB760_17570	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HB760_17580	COG2207	Transcriptional regulator
HB760_17585	COG2807	transmembrane transport
HB760_17595	COG0574	Belongs to the PEP-utilizing enzyme family
HB760_17595	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HB760_17620	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HB760_17630	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HB760_17665	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB760_17695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB760_17745	COG4948	Mandelate Racemase Muconate Lactonizing
HB760_17785	COG4176	ABC-type proline glycine betaine transport system permease component
HB760_17790	COG4175	Glycine betaine
HB760_17790	COG3448	diguanylate cyclase activity
HB760_17805	COG0583	DNA-binding transcription factor activity
HB760_17815	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HB760_17825	COG3136	membrane protein required for alginate biosynthesis
HB760_17850	COG1335	isochorismatase
HB760_17865	COG1349	DNA-binding transcription factor activity
HB760_17870	COG0346	lactoylglutathione lyase activity
HB760_17905	COG1280	lysine exporter protein (LysE YggA)
HB760_17910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HB760_17925	COG0488	(ABC) transporter
HB760_17930	COG0435	Glutathione S-transferase
HB760_17935	COG0431	NADPH-dependent FMN reductase
HB760_17940	COG0583	DNA-binding transcription factor activity
HB760_17945	COG4628	conserved protein (DUF2132)
HB760_17950	COG0488	(ABC) transporter
HB760_17965	COG0346	lactoylglutathione lyase activity
HB760_17970	COG0384	phenazine biosynthesis protein PhzF
HB760_17990	COG2205	protein histidine kinase activity
HB760_17995	COG0745	RESPONSE REGULATOR receiver
HB760_18005	COG0454	-acetyltransferase
HB760_18015	COG2814	Major facilitator Superfamily
HB760_18025	COG2988	succinylglutamate desuccinylase activity
HB760_18035	COG0628	permease
HB760_18040	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HB760_18055	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB760_18065	COG4628	conserved protein (DUF2132)
HB760_18070	COG0583	DNA-binding transcription factor activity
HB760_18080	COG1686	Belongs to the peptidase S11 family
HB760_18100	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HB760_18105	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HB760_18120	COG0415	Belongs to the DNA photolyase family
HB760_18125	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HB760_18135	COG4667	esterase of the alpha-beta hydrolase superfamily
HB760_18150	COG1596	polysaccharide export
HB760_18160	COG3206	protein involved in exopolysaccharide biosynthesis
HB760_18160	COG0489	protein tyrosine kinase activity
HB760_18180	COG1301	dicarboxylic acid transport
HB760_18185	COG3339	Conserved Protein
HB760_18200	COG2207	Transcriptional regulator
HB760_18215	COG0366	Alpha amylase catalytic
HB760_18220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HB760_18225	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HB760_18230	COG1640	4-alpha-glucanotransferase
HB760_18235	COG0058	SHG alpha-glucan phosphorylase activity
HB760_18255	COG1999	signal sequence binding
HB760_18265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HB760_18265	COG1263	PTS System
HB760_18270	COG1162	GTPase activity
HB760_18275	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HB760_18300	COG4589	Belongs to the CDS family
HB760_18350	COG2356	endonuclease I
HB760_18390	COG2814	Major facilitator Superfamily
HB760_18405	COG0739	heme binding
HB760_18440	COG3121	Chaperone
HB760_18445	COG3188	usher protein
HB760_18475	COG0612	Peptidase, M16
HB760_18480	COG0840	transmembrane signaling receptor activity
HB760_18500	COG1335	isochorismatase
HB760_18505	COG1136	(ABC) transporter
HB760_18510	COG0577	efflux transmembrane transporter activity
HB760_18545	COG1764	response to oxidative stress
HB760_18550	COG1846	Transcriptional regulator
HB760_18570	COG3634	alkyl hydroperoxide reductase activity
HB760_18580	COG2610	gluconate transmembrane transporter activity
HB760_18585	COG3622	Belongs to the hyi family
HB760_18590	COG0235	Class ii aldolase
HB760_18595	COG3395	kinase activity
HB760_18600	COG2084	Dehydrogenase
HB760_18605	COG1349	DNA-binding transcription factor activity
HB760_18635	COG1522	sequence-specific DNA binding
HB760_18640	COG0544	peptidyl-prolyl cis-trans isomerase activity
HB760_18645	COG0544	peptidyl-prolyl cis-trans isomerase activity
HB760_18650	COG2207	Transcriptional regulator
HB760_18660	COG2258	MOSC domain
HB760_18665	COG2153	protein acetylation
HB760_18675	COG3713	MltA-interacting MipA family protein
HB760_18680	COG0513	Belongs to the DEAD box helicase family
HB760_18685	COG0667	Aldo Keto reductase
HB760_18705	COG1132	(ABC) transporter
HB760_18830	COG4166	transmembrane transport
HB760_18860	COG1595	DNA-templated transcription, initiation
HB760_18900	COG0848	biopolymer transport protein
HB760_18905	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HB760_18910	COG1444	tRNA N-acetyltransferase activity
HB760_18935	COG4608	Belongs to the ABC transporter superfamily
HB760_18940	COG0444	Belongs to the ABC transporter superfamily
HB760_18950	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
HB760_18950	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HB760_18985	COG1136	(ABC) transporter
HB760_19005	COG3275	phosphorelay sensor kinase activity
HB760_19010	COG3279	Response regulator of the LytR AlgR family
HB760_19015	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HB760_19030	COG0786	glutamate:sodium symporter activity
HB760_19035	COG1028	Short-chain dehydrogenase reductase Sdr
HB760_19085	COG0583	DNA-binding transcription factor activity
HB760_19100	COG2897	thiosulfate sulfurtransferase activity
HB760_19110	COG1131	(ABC) transporter
HB760_19115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB760_19150	COG0561	phosphatase activity
HB760_19155	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HB760_19160	COG3623	hexulose-6-phosphate isomerase
HB760_19195	COG2259	Doxx family
HB760_19205	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HB760_19210	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HB760_19280	COG1609	Transcriptional regulator
HB760_19295	COG0395	ABC-type sugar transport system, permease component
HB760_19300	COG2723	6-phospho-beta-galactosidase activity
HB760_19305	COG3842	ATPase activity
HB760_19310	COG1609	Transcriptional regulator
HB760_19320	COG0564	pseudouridine synthase activity
HB760_19325	COG0561	phosphatase activity
HB760_19345	COG3152	Membrane
HB760_19355	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HB760_19370	COG0583	DNA-binding transcription factor activity
HB760_19415	COG2076	Multidrug Resistance protein
HB760_19425	COG1357	PFAM Pentapeptide repeats (8 copies)
HB760_19430	COG3047	cAMP biosynthetic process
HB760_19520	COG0668	transmembrane transport
HB760_19565	COG3835	regulator
HB760_19570	COG1929	Belongs to the glycerate kinase type-1 family
HB760_19575	COG0477	Major facilitator Superfamily
HB760_19590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB760_19640	COG1028	Short-chain dehydrogenase reductase Sdr
HB760_19660	COG0671	phosphoesterase, PA-phosphatase related
HB760_19670	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HB760_19675	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HB760_19680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB760_19685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB760_19690	COG1116	anion transmembrane transporter activity
HB760_19695	COG0351	phosphomethylpyrimidine kinase
HB760_19705	COG0312	modulator of DNA gyrase
HB760_19765	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HB760_19775	COG0584	glycerophosphoryl diester phosphodiesterase
HB760_19780	COG0745	RESPONSE REGULATOR receiver
HB760_19800	COG0811	peptide transport
HB760_19805	COG0811	peptide transport
HB760_19810	COG0848	biopolymer transport protein
HB760_19860	COG1121	(ABC) transporter
HB760_19865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HB760_19880	COG1770	oligopeptidase
HB760_19885	COG2814	Major facilitator Superfamily
HB760_19890	COG0010	Belongs to the arginase family
HB760_19895	COG1166	arginine decarboxylase activity
HB760_19905	COG0189	ligase activity
HB760_19905	COG4067	protein conserved in archaea
HB760_19910	COG0189	ligase activity
HB760_19930	COG0583	DNA-binding transcription factor activity
HB760_19955	COG2723	6-phospho-beta-galactosidase activity
HB760_19970	COG1114	Component of the transport system for branched-chain amino acids
HB760_19985	COG0579	oxidoreductase
HB760_19990	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HB760_20005	COG3033	Beta-eliminating lyase
HB760_20020	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HB760_20025	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HB760_20060	COG3706	GGDEF domain
HB760_20065	COG0415	Belongs to the DNA photolyase family
HB760_20070	COG3046	protein related to deoxyribodipyrimidine photolyase
HB760_20085	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HB760_20085	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HB760_20090	COG1765	OsmC-like protein
HB760_20130	COG1011	Hydrolase
HB760_20155	COG3240	lipase activity
HB760_20175	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HB760_20185	COG1840	ABC-type Fe3 transport system, periplasmic component
HB760_20190	COG3842	ATPase activity
HB760_20215	COG2990	Protein conserved in bacteria
HB760_20225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB760_20230	COG2866	Carboxypeptidase
HB760_20240	COG0583	DNA-binding transcription factor activity
HB760_20265	COG3104	oligopeptide transport
HB760_20270	COG1760	l-serine dehydratase
HB760_20300	COG0741	lytic transglycosylase activity
HB760_20300	COG1388	LysM domain
HB760_20320	COG1815	bacterial-type flagellum-dependent cell motility
HB760_20325	COG1558	bacterial-type flagellum-dependent cell motility
HB760_20330	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HB760_20335	COG1749	Flagellar hook protein flgE
HB760_20340	COG4787	bacterial-type flagellum-dependent cell motility
HB760_20345	COG4786	Flagellar basal body rod
HB760_20350	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HB760_20355	COG1706	bacterial-type flagellum-dependent cell motility
HB760_20365	COG1256	bacterial-type flagellum assembly
HB760_20365	COG4786	Flagellar basal body rod
HB760_20435	COG0384	phenazine biosynthesis protein PhzF
HB760_20445	COG1360	Flagellar Motor Protein
HB760_20450	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HB760_20455	COG1191	sigma factor activity
HB760_20460	COG1580	Controls the rotational direction of flagella during chemotaxis
HB760_20480	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HB760_20490	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HB760_20505	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HB760_20515	COG1987	bacterial-type flagellum assembly
HB760_20615	COG0346	lactoylglutathione lyase activity
HB760_20650	COG0156	8-amino-7-oxononanoate synthase activity
HB760_20655	COG1063	alcohol dehydrogenase
HB760_20660	COG4974	Belongs to the 'phage' integrase family
HB760_20785	COG4695	Portal protein
HB760_20885	COG0584	glycerophosphoryl diester phosphodiesterase
HB760_20935	COG1063	alcohol dehydrogenase
HB760_20960	COG2203	Gaf domain
HB760_20960	COG2199	diguanylate cyclase activity
HB760_20965	COG2223	nitrite transmembrane transporter activity
HB760_20970	COG1063	alcohol dehydrogenase
HB760_20980	COG0668	transmembrane transport
HB760_20990	COG1304	FMN binding
HB760_21000	COG1620	l-lactate permease
HB760_21005	COG0583	DNA-binding transcription factor activity
HB760_21010	COG1505	serine-type exopeptidase activity
HB760_21015	COG4172	Belongs to the ABC transporter superfamily
HB760_21025	COG1067	ATP-dependent peptidase activity
HB760_21035	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HB760_21055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HB760_21075	COG1122	ATPase activity
HB760_21085	COG1566	PFAM secretion protein HlyD family protein
HB760_21115	COG0813	purine-nucleoside phosphorylase activity
HB760_21120	COG3272	Protein of unknown function (DUF1722)
HB760_21125	COG0789	Transcriptional regulator
HB760_21130	COG0415	Belongs to the DNA photolyase family
HB760_21135	COG1376	ErfK ybiS ycfS ynhG family protein
HB760_21135	COG1388	LysM domain
HB760_21150	COG0672	)-iron permease
HB760_21255	COG4695	Portal protein
HB760_21305	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HB760_21355	COG0584	glycerophosphoryl diester phosphodiesterase
HB760_21400	COG1280	lysine exporter protein (LysE YggA)
HB760_21410	COG2732	(Barnase) inhibitor
HB760_21445	COG0513	Belongs to the DEAD box helicase family
HB760_21455	COG1770	oligopeptidase
HB760_21480	COG0840	transmembrane signaling receptor activity
HB760_21490	COG0573	inorganic phosphate transmembrane transporter activity
HB760_21495	COG0581	inorganic phosphate transmembrane transporter activity
HB760_21500	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HB760_21515	COG2304	oxidoreductase activity
HB760_21535	COG0714	Associated with various cellular activities
HB760_21545	COG0840	transmembrane signaling receptor activity
HB760_21555	COG2197	response regulator
HB760_21580	COG2204	response regulator
HB760_21585	COG3852	Histidine kinase
HB760_21625	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
HB760_21650	COG1252	NADH dehydrogenase
HB760_21655	COG1301	dicarboxylic acid transport
HB760_21660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HB760_21685	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HB760_21685	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HB760_21685	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB760_21700	COG2084	Dehydrogenase
HB760_21705	COG0753	catalase activity
HB760_21715	COG2130	NADP-dependent
HB760_21720	COG1309	transcriptional regulator
HB760_21765	COG0489	protein tyrosine kinase activity
HB760_21765	COG3206	protein involved in exopolysaccharide biosynthesis
HB760_21780	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HB760_21785	COG3842	ATPase activity
HB760_21795	COG1175	transmembrane transport
HB760_21800	COG3833	ABC-type maltose transport systems, permease component
HB760_21830	COG2354	Protein conserved in bacteria
HB760_21840	COG0401	homolog of Blt101
HB760_21845	COG3217	Mosc domain protein beta barrel domain protein
HB760_21845	COG0633	Ferredoxin
HB760_21845	COG3217	Mosc domain protein beta barrel domain protein
HB760_21845	COG0633	Ferredoxin
HB760_21855	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HB760_21895	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HB760_21900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HB760_21910	COG0848	biopolymer transport protein
HB760_21915	COG0811	peptide transport
HB760_21920	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HB760_21930	COG3721	Heme iron utilization protein
HB760_21935	COG0748	coenzyme F420 binding
HB760_21945	COG0784	Response regulator, receiver
HB760_21945	COG0835	chemotaxis
HB760_21950	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HB760_21955	COG0366	Alpha amylase catalytic
HB760_21990	COG0583	DNA-binding transcription factor activity
HB760_22005	COG2249	NAD(P)H dehydrogenase (quinone) activity
HB760_22015	COG2814	Major facilitator Superfamily
HB760_22025	COG4977	sequence-specific DNA binding
HB760_22030	COG0673	inositol 2-dehydrogenase activity
HB760_22035	COG2194	sulfuric ester hydrolase activity
HB760_22040	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HB760_22050	COG2205	protein histidine kinase activity
HB760_22055	COG0745	RESPONSE REGULATOR receiver
HB760_22060	COG4221	oxidoreductase activity
HB760_22075	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB760_22095	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HB760_22105	COG2814	Major facilitator Superfamily
HB760_22120	COG1418	mRNA catabolic process
HB760_22135	COG0402	S-adenosylhomocysteine deaminase activity
HB760_22140	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HB760_22145	COG2239	Acts as a magnesium transporter
HB760_22150	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HB760_22155	COG1566	PFAM secretion protein HlyD family protein
HB760_22180	COG0745	RESPONSE REGULATOR receiver
HB760_22185	COG2205	protein histidine kinase activity
HB760_22200	COG0531	amino acid
HB760_22205	COG1522	sequence-specific DNA binding
HB760_22215	COG0583	DNA-binding transcription factor activity
HB760_22240	COG0673	inositol 2-dehydrogenase activity
HB760_22320	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HB760_22325	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HB760_22335	COG1280	lysine exporter protein (LysE YggA)
HB760_22345	COG0183	Belongs to the thiolase family
HB760_22365	COG3005	denitrification pathway
HB760_22385	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HB760_22390	COG3850	Histidine kinase
HB760_22395	COG2197	response regulator
HB760_22420	COG0840	transmembrane signaling receptor activity
HB760_22430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HB760_22435	COG0545	Peptidyl-prolyl cis-trans isomerase
HB760_22465	COG1278	Cold shock
HB760_22470	COG3036	rescue of stalled ribosome
HB760_22480	COG2199	diguanylate cyclase activity
HB760_22500	COG1136	(ABC) transporter
HB760_22515	COG0783	Belongs to the Dps family
HB760_22525	COG1619	proteins homologs of microcin C7 resistance protein MccF
HB760_22530	COG2133	pyrroloquinoline quinone binding
HB760_22535	COG1454	alcohol dehydrogenase
HB760_22540	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HB760_22565	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HB760_22570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB760_22575	COG3186	Phenylalanine-4-hydroxylase
HB760_22600	COG3530	Putative quorum-sensing-regulated virulence factor
HB760_22625	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HB760_22630	COG1845	cytochrome c oxidase, subunit III
HB760_22635	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HB760_22640	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HB760_22650	COG0454	-acetyltransferase
HB760_22685	COG0523	cobalamin synthesis protein
HB760_22690	COG5001	Diguanylate cyclase
HB760_22690	COG3447	MASE1 domain protein
HB760_22690	COG5002	protein histidine kinase activity
HB760_22695	COG0513	Belongs to the DEAD box helicase family
HB760_22715	COG2200	EAL domain
HB760_22720	COG1119	ATPase activity
HB760_22735	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HB760_22750	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HB760_22755	COG0513	Belongs to the DEAD box helicase family
HB760_22760	COG5001	Diguanylate cyclase
HB760_22765	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HB760_22780	COG3278	Belongs to the heme-copper respiratory oxidase family
HB760_22820	COG1024	Enoyl-CoA hydratase
HB760_22825	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HB760_22830	COG1960	acyl-CoA dehydrogenase activity
HB760_22840	COG0183	Belongs to the thiolase family
HB760_22855	COG1024	Enoyl-CoA hydratase
HB760_22860	COG1024	Enoyl-CoA hydratase
HB760_22870	COG1028	Short-chain dehydrogenase reductase Sdr
HB760_22875	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HB760_22880	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HB760_22885	COG1845	cytochrome c oxidase, subunit III
HB760_22890	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HB760_22900	COG1902	pentaerythritol trinitrate reductase activity
HB760_22900	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB760_22915	COG1012	belongs to the aldehyde dehydrogenase family
HB760_22925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB760_22960	COG1126	abc transporter atp-binding protein
HB760_22965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB760_22970	COG4215	(ABC) transporter
HB760_22975	COG4160	amino acid transport
HB760_23010	COG5002	protein histidine kinase activity
HB760_23015	COG2200	EAL domain
HB760_23060	COG0443	Heat shock 70 kDa protein
HB760_23085	COG1785	Belongs to the alkaline phosphatase family
HB760_23155	COG0814	amino acid
HB760_23210	COG0739	heme binding
HB760_23305	COG2814	Major facilitator Superfamily
HB760_23320	COG2816	NAD+ diphosphatase activity
HB760_23350	COG1132	(ABC) transporter
HB760_23370	COG0583	DNA-binding transcription factor activity
HB760_23450	COG1120	ATPase activity
HB760_23455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HB760_23460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HB760_23465	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HB760_23510	COG3005	denitrification pathway
HB760_23660	COG0519	Catalyzes the synthesis of GMP from XMP
HB760_23675	COG1335	isochorismatase
HB760_23735	COG2801	Transposase and inactivated derivatives
HB760_23805	COG2801	Transposase and inactivated derivatives
HB760_23820	COG0284	orotidine-5'-phosphate decarboxylase activity
HB760_23825	COG1335	isochorismatase
HB760_23855	COG2801	Transposase and inactivated derivatives
HB760_23875	COG1028	Short-chain dehydrogenase reductase Sdr
HB760_23880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HB760_23885	COG1720	tRNA m6t6A37 methyltransferase activity
HB760_23905	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HB760_23915	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HB760_23925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB760_23930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB760_23945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HB760_23945	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HB760_23945	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HB760_23950	COG1105	Belongs to the carbohydrate kinase PfkB family
HB760_23955	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB760_23955	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB760_23960	COG1609	Transcriptional regulator
HB760_23975	COG2203	Gaf domain
HB760_23975	COG2199	diguanylate cyclase activity
HB760_23975	COG2200	EAL domain
HB760_23980	COG0765	amino acid transport
HB760_23985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB760_23990	COG0765	amino acid transport
HB760_23995	COG1126	abc transporter atp-binding protein
HB760_24005	COG1979	alcohol dehydrogenase
HB760_24010	COG2207	Transcriptional regulator
HB760_24020	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HB760_24030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HB760_24045	COG3437	response regulator, receiver
HB760_24050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HB760_24060	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HB760_24065	COG0513	Belongs to the DEAD box helicase family
HB760_24070	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HB760_24085	COG3038	cytochrome b561
HB760_24095	COG2116	formate transmembrane transporter activity
HB760_24100	COG0583	DNA-binding transcription factor activity
HB760_24110	COG3593	DNA synthesis involved in DNA repair
HB760_24115	COG0737	Belongs to the 5'-nucleotidase family
HB760_24120	COG0861	Integral membrane protein TerC family
HB760_24130	COG1410	methionine synthase
HB760_24130	COG0646	methionine synthase
HB760_24135	COG0076	glutamate decarboxylase activity
HB760_24280	COG2267	carboxylic ester hydrolase activity
HB760_24285	COG2067	long-chain fatty acid transport protein
HB760_24295	COG0501	Belongs to the peptidase M48B family
HB760_24300	COG2050	protein possibly involved in aromatic compounds catabolism
HB760_24335	COG0484	heat shock protein binding
HB760_24345	COG5001	Diguanylate cyclase
HB760_24345	COG3300	MHYT domain
HB760_24350	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HB760_24360	COG4181	ATPase activity
HB760_24365	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HB760_24375	COG1984	allophanate hydrolase subunit 2
HB760_24380	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HB760_24390	COG5001	Diguanylate cyclase
HB760_24390	COG3447	MASE1 domain protein
HB760_24390	COG5002	protein histidine kinase activity
HB760_24395	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HB760_24405	COG0583	DNA-binding transcription factor activity
HB760_24410	COG1042	CoA-binding domain protein
HB760_24410	COG0045	succinate-CoA ligase (ADP-forming) activity
HB760_24410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HB760_24430	COG0023	Translation Initiation Factor
HB760_24445	COG3140	Belongs to the UPF0181 family
HB760_24470	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HB760_24475	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HB760_24495	COG5001	Diguanylate cyclase
HB760_24495	COG2203	Gaf domain
HB760_24495	COG4251	negative regulation of phosphorylation
HB760_24495	COG3706	GGDEF domain
HB760_24505	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HB760_24510	COG4149	molybdate abc transporter
HB760_24515	COG0725	ABC transporter, periplasmic molybdate-binding protein
HB760_24525	COG3111	PFAM Bacterial OB fold (BOF) protein
HB760_24545	COG2207	Transcriptional regulator
HB760_24555	COG0602	queuosine metabolic process
HB760_24560	COG1328	CTP reductase activity
HB760_24615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HB760_24620	COG3118	belongs to the thioredoxin family
HB760_24645	COG0840	transmembrane signaling receptor activity
HB760_24650	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HB760_24665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HB760_24665	COG1648	precorrin-2 dehydrogenase activity
HB760_24725	COG0277	FAD linked oxidase domain protein
HB760_24730	COG0583	DNA-binding transcription factor activity
HB760_24745	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HB760_24760	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HB760_24770	COG1288	antiporter activity
HB760_24780	COG3040	lipid binding
HB760_24810	COG3469	chitinase activity
HB760_24820	COG0419	ATPase involved in DNA repair
HB760_24825	COG0420	3'-5' exonuclease activity
HB760_24845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HB760_24850	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HB760_24865	COG0840	transmembrane signaling receptor activity
HB760_24890	COG2755	lipolytic protein G-D-S-L family
HB760_24890	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HB760_24900	COG5642	Protein of unknown function (DUF2384)
HB760_24940	COG0671	phosphoesterase, PA-phosphatase related
HB760_24950	COG2962	Rard protein
HB760_24960	COG0784	Response regulator, receiver
HB760_24960	COG0835	chemotaxis
HB760_24965	COG0778	Nitroreductase
HB760_25340	COG1522	sequence-specific DNA binding
HB760_25375	COG0515	serine threonine protein kinase
HB760_25400	COG3501	Rhs element vgr protein
HB760_25530	COG0739	heme binding
HB760_25545	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HB760_25575	COG3069	C4-dicarboxylate transmembrane transporter activity
HB760_25605	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HB760_25615	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HB760_25675	COG2205	protein histidine kinase activity
HB760_25675	COG2198	Histidine kinase
HB760_25675	COG0784	Response regulator, receiver
HB760_25680	COG1879	ABC-type sugar transport system periplasmic component
HB760_25690	COG0210	DNA helicase
HB760_25695	COG1289	transmembrane transporter activity
HB760_25720	COG0789	Transcriptional regulator
HB760_25725	COG4604	ABC transporter, ATP-binding protein
HB760_25730	COG4605	iron ion homeostasis
HB760_25735	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HB760_25740	COG4607	ABC-type enterochelin transport system periplasmic component
HB760_25755	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HB760_25770	COG1609	Transcriptional regulator
HB760_25775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HB760_25780	COG1879	ABC-type sugar transport system periplasmic component
HB760_25785	COG1172	Belongs to the binding-protein-dependent transport system permease family
HB760_25790	COG1129	ABC transporter
HB760_25800	COG5001	Diguanylate cyclase
HB760_25830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HB760_25835	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HB760_25840	COG1192	Involved in chromosome partitioning
HB760_25965	COG4821	SIS domain
HB760_26010	COG0778	Nitroreductase
HB760_26065	COG3121	Chaperone
HB760_26240	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HB760_26245	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HB760_26250	COG1192	Involved in chromosome partitioning