locus-tag	class	description
VAB027_1	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VAB027_10	COG0752	glycyl-tRNA synthetase alpha subunit
VAB027_100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VAB027_1004	COG3501	Rhs element vgr protein
VAB027_1006	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VAB027_1007	COG1640	4-alpha-glucanotransferase
VAB027_1008	COG0058	SHG alpha-glucan phosphorylase activity
VAB027_1009	COG2909	trisaccharide binding
VAB027_101	COG3071	HemY protein
VAB027_1013	COG2084	Dehydrogenase
VAB027_1014	COG0217	transcriptional regulatory protein
VAB027_102	COG2959	enzyme of heme biosynthesis
VAB027_1021	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VAB027_1022	COG1444	tRNA N-acetyltransferase activity
VAB027_1026	COG4221	oxidoreductase activity
VAB027_1028	COG0745	RESPONSE REGULATOR receiver
VAB027_1029	COG0642	Histidine kinase
VAB027_103	COG1587	Uroporphyrinogen-III synthase
VAB027_1030	COG2194	sulfuric ester hydrolase activity
VAB027_1031	COG4608	Belongs to the ABC transporter superfamily
VAB027_1032	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAB027_1033	COG0601	transmembrane transport
VAB027_1037	COG2198	Histidine kinase
VAB027_1037	COG0643	Histidine kinase
VAB027_1038	COG0835	chemotaxis
VAB027_1039	COG0835	chemotaxis
VAB027_104	COG0181	hydroxymethylbilane synthase activity
VAB027_1040	COG0840	transmembrane signaling receptor activity
VAB027_1041	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VAB027_1042	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
VAB027_1047	COG0745	RESPONSE REGULATOR receiver
VAB027_105	COG3072	Adenylate cyclase
VAB027_1054	COG0259	pyridoxamine-phosphate oxidase activity
VAB027_1057	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VAB027_106	COG1965	Belongs to the frataxin family
VAB027_1063	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VAB027_1068	COG1982	Orn Lys Arg decarboxylase major
VAB027_1069	COG0531	amino acid
VAB027_107	COG0019	diaminopimelate decarboxylase activity
VAB027_1070	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VAB027_1071	COG1901	pseudouridine methyltransferase
VAB027_1073	COG4221	oxidoreductase activity
VAB027_1074	COG0840	transmembrane signaling receptor activity
VAB027_1076	COG2910	NAD(P)H-binding
VAB027_1078	COG1335	isochorismatase
VAB027_108	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VAB027_1081	COG0697	spore germination
VAB027_1086	COG0673	inositol 2-dehydrogenase activity
VAB027_1087	COG3722	fumarate hydratase activity
VAB027_1088	COG0246	Mannitol dehydrogenase
VAB027_1089	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAB027_1089	COG2213	PTS system mannitol-specific
VAB027_1090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VAB027_1091	COG4597	amino acid ABC transporter
VAB027_1092	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAB027_1094	COG1126	abc transporter atp-binding protein
VAB027_1095	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VAB027_1097	COG0840	transmembrane signaling receptor activity
VAB027_11	COG2119	membrane
VAB027_110	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VAB027_1100	COG0840	transmembrane signaling receptor activity
VAB027_1103	COG4580	involved in the transport of maltose and maltodextrins
VAB027_1106	COG0363	glucosamine-6-phosphate deaminase activity
VAB027_111	COG1011	Hydrolase
VAB027_1111	COG2259	Doxx family
VAB027_1112	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
VAB027_1113	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VAB027_1115	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
VAB027_1116	COG3366	ferrous iron transmembrane transporter activity
VAB027_1117	COG0700	Nucleoside recognition
VAB027_1119	COG0697	spore germination
VAB027_112	COG2200	EAL domain
VAB027_112	COG2199	diguanylate cyclase activity
VAB027_112	COG3287	FIST C domain
VAB027_1120	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VAB027_1121	COG1764	response to oxidative stress
VAB027_1122	COG1846	Transcriptional regulator
VAB027_1126	COG2207	Transcriptional regulator
VAB027_1127	COG1280	lysine exporter protein (LysE YggA)
VAB027_1129	COG1902	pentaerythritol trinitrate reductase activity
VAB027_1131	COG1132	(ABC) transporter
VAB027_1133	COG1902	pentaerythritol trinitrate reductase activity
VAB027_1135	COG0583	DNA-binding transcription factor activity
VAB027_1136	COG0513	Belongs to the DEAD box helicase family
VAB027_1137	COG1943	Transposase
VAB027_1140	COG0840	transmembrane signaling receptor activity
VAB027_1142	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
VAB027_1144	COG1304	FMN binding
VAB027_1145	COG1620	l-lactate permease
VAB027_1146	COG0583	DNA-binding transcription factor activity
VAB027_115	COG0561	phosphatase activity
VAB027_1150	COG4172	Belongs to the ABC transporter superfamily
VAB027_1152	COG1067	ATP-dependent peptidase activity
VAB027_1153	COG0840	transmembrane signaling receptor activity
VAB027_1155	COG2211	Major facilitator Superfamily
VAB027_1157	COG3123	guanosine phosphorylase activity
VAB027_1158	COG1741	Belongs to the pirin family
VAB027_116	COG2267	carboxylic ester hydrolase activity
VAB027_1160	COG5001	Diguanylate cyclase
VAB027_1161	COG0583	DNA-binding transcription factor activity
VAB027_1168	COG3706	GGDEF domain
VAB027_1169	COG1846	Transcriptional regulator
VAB027_117	COG1280	lysine exporter protein (LysE YggA)
VAB027_1170	COG0784	Response regulator, receiver
VAB027_1170	COG0835	chemotaxis
VAB027_1171	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VAB027_1172	COG2197	response regulator
VAB027_1173	COG0393	Putative heavy-metal-binding
VAB027_1176	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VAB027_1177	COG3842	ATPase activity
VAB027_1179	COG1175	transmembrane transport
VAB027_118	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VAB027_1180	COG3833	ABC-type maltose transport systems, permease component
VAB027_1183	COG1349	DNA-binding transcription factor activity
VAB027_1184	COG3706	GGDEF domain
VAB027_1189	COG1278	Cold shock
VAB027_119	COG0783	Belongs to the Dps family
VAB027_1191	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VAB027_1192	COG2354	Protein conserved in bacteria
VAB027_1193	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VAB027_1194	COG0418	dihydroorotase activity
VAB027_1195	COG0633	Ferredoxin
VAB027_1195	COG3217	Mosc domain protein beta barrel domain protein
VAB027_1195	COG0633	Ferredoxin
VAB027_1195	COG3217	Mosc domain protein beta barrel domain protein
VAB027_1202	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VAB027_1203	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VAB027_1204	COG4558	Periplasmic binding protein
VAB027_1205	COG0848	biopolymer transport protein
VAB027_1206	COG0811	peptide transport
VAB027_1207	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VAB027_1209	COG3721	Heme iron utilization protein
VAB027_1210	COG0748	coenzyme F420 binding
VAB027_1212	COG1929	Belongs to the glycerate kinase type-1 family
VAB027_1217	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VAB027_1218	COG0363	glucosamine-6-phosphate deaminase activity
VAB027_1219	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VAB027_1220	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VAB027_1221	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
VAB027_1225	COG0346	lactoylglutathione lyase activity
VAB027_1227	COG2873	o-acetylhomoserine
VAB027_1229	COG1063	alcohol dehydrogenase
VAB027_1230	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VAB027_1231	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VAB027_1237	COG2801	Transposase and inactivated derivatives
VAB027_1238	COG0582	viral genome integration into host DNA
VAB027_124	COG0742	ribosomal rna small subunit methyltransferase
VAB027_1244	COG1802	Transcriptional regulator
VAB027_1244	COG4626	Terminase
VAB027_1249	COG1278	Cold shock
VAB027_125	COG0552	protein localization to endoplasmic reticulum
VAB027_1253	COG2351	hydroxyisourate hydrolase activity
VAB027_1255	COG3385	transposase activity
VAB027_1256	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VAB027_1257	COG3954	Phosphoribulokinase
VAB027_1259	COG0429	hydrolase of the alpha beta-hydrolase fold
VAB027_126	COG2884	Cell division ATP-binding protein ftsE
VAB027_1261	COG0488	(ABC) transporter
VAB027_1262	COG2249	NAD(P)H dehydrogenase (quinone) activity
VAB027_1265	COG1047	Peptidyl-prolyl cis-trans
VAB027_1267	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VAB027_1268	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VAB027_1269	COG3083	sulfuric ester hydrolase activity
VAB027_127	COG2177	Part of the ABC transporter FtsEX involved in
VAB027_1270	COG0557	exoribonuclease II activity
VAB027_1271	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VAB027_1272	COG0051	transcription antitermination factor activity, RNA binding
VAB027_1273	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VAB027_1274	COG0088	Forms part of the polypeptide exit tunnel
VAB027_1275	COG0089	rRNA binding
VAB027_1276	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VAB027_1277	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VAB027_1278	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VAB027_1279	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VAB027_128	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VAB027_1280	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VAB027_1281	COG0255	Belongs to the universal ribosomal protein uL29 family
VAB027_1282	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VAB027_1283	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VAB027_1284	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VAB027_1285	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VAB027_1286	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VAB027_1287	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VAB027_1288	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VAB027_1289	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VAB027_129	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VAB027_1290	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VAB027_1291	COG1841	ribosomal large subunit assembly
VAB027_1292	COG0200	Binds to the 23S rRNA
VAB027_1293	COG0201	protein transport
VAB027_1295	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VAB027_1296	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VAB027_1297	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VAB027_1298	COG0202	RNA polymerase activity
VAB027_1299	COG0203	ribosomal protein L17
VAB027_13	COG0425	Belongs to the sulfur carrier protein TusA family
VAB027_1301	COG0545	Peptidyl-prolyl cis-trans isomerase
VAB027_1302	COG0697	spore germination
VAB027_1303	COG3266	domain, Protein
VAB027_1303	COG3061	Opacity-associated protein A
VAB027_1304	COG2153	protein acetylation
VAB027_1305	COG0513	Belongs to the DEAD box helicase family
VAB027_1307	COG0737	Belongs to the 5'-nucleotidase family
VAB027_1308	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VAB027_1308	COG1648	precorrin-2 dehydrogenase activity
VAB027_1309	COG0175	sulfate reduction
VAB027_1310	COG2895	sulfate adenylyltransferase (ATP) activity
VAB027_1311	COG0529	Catalyzes the synthesis of activated sulfate
VAB027_1315	COG1136	(ABC) transporter
VAB027_1318	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VAB027_1319	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAB027_132	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VAB027_1320	COG0729	surface antigen
VAB027_1322	COG2105	PFAM AIG2 family protein
VAB027_1323	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VAB027_1324	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VAB027_1325	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VAB027_1326	COG0163	prenyltransferase activity
VAB027_1327	COG4143	(ABC) transporter
VAB027_1328	COG1178	ABC-type Fe3 transport system permease component
VAB027_1329	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VAB027_1330	COG3028	Belongs to the UPF0307 family
VAB027_1331	COG0312	modulator of DNA gyrase
VAB027_1332	COG2239	Acts as a magnesium transporter
VAB027_1333	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAB027_1335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAB027_1336	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VAB027_1338	COG1137	ATPase activity
VAB027_1339	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VAB027_134	COG1943	Transposase
VAB027_1342	COG0517	IMP dehydrogenase activity
VAB027_1342	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VAB027_1344	COG1127	ABC transporter
VAB027_1345	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VAB027_1346	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VAB027_1347	COG2854	intermembrane phospholipid transfer
VAB027_1349	COG5007	Belongs to the BolA IbaG family
VAB027_135	COG1404	Belongs to the peptidase S8 family
VAB027_1350	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VAB027_1351	COG0204	Acyl-transferase
VAB027_1352	COG0251	oxidation-reduction process
VAB027_1353	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VAB027_1354	COG0540	Belongs to the ATCase OTCase family
VAB027_1356	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VAB027_1357	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VAB027_1358	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VAB027_1359	COG0564	pseudouridine synthase activity
VAB027_1360	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VAB027_1361	COG0525	valine-tRNA ligase activity
VAB027_1362	COG2927	DNA polymerase III (CHI subunit)
VAB027_1363	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VAB027_1364	COG0795	lipopolysaccharide-transporting ATPase activity
VAB027_1365	COG0795	lipopolysaccharide-transporting ATPase activity
VAB027_1368	COG3437	response regulator, receiver
VAB027_137	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VAB027_1377	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VAB027_1379	COG2974	May be involved in recombination
VAB027_1380	COG0745	RESPONSE REGULATOR receiver
VAB027_1381	COG5002	protein histidine kinase activity
VAB027_1383	COG0248	Ppx GppA phosphatase
VAB027_1384	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VAB027_1386	COG0581	inorganic phosphate transmembrane transporter activity
VAB027_1387	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VAB027_1390	COG3142	Participates in the control of copper homeostasis
VAB027_1391	COG0450	alkyl hydroperoxide reductase
VAB027_1392	COG0583	DNA-binding transcription factor activity
VAB027_1393	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VAB027_1395	COG0517	IMP dehydrogenase activity
VAB027_1396	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VAB027_1397	COG0343	queuine tRNA-ribosyltransferase activity
VAB027_1398	COG1862	Preprotein translocase
VAB027_1399	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VAB027_1400	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VAB027_1401	COG0483	inositol monophosphate 1-phosphatase activity
VAB027_1403	COG1959	2 iron, 2 sulfur cluster binding
VAB027_1404	COG1104	cysteine desulfurase activity
VAB027_1405	COG0822	iron-sulfur transferase activity
VAB027_1409	COG0633	Ferredoxin
VAB027_1410	COG2975	iron-sulfur cluster assembly
VAB027_1411	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VAB027_1412	COG0105	UTP biosynthetic process
VAB027_1414	COG1426	Protein conserved in bacteria
VAB027_1415	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VAB027_1416	COG0124	histidyl-tRNA synthetase
VAB027_1417	COG2976	Protein conserved in bacteria
VAB027_1418	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAB027_1419	COG1160	GTP binding
VAB027_1421	COG1570	exodeoxyribonuclease VII activity
VAB027_1423	COG0517	IMP dehydrogenase activity
VAB027_1423	COG0516	GMP reductase activity
VAB027_1424	COG0519	Catalyzes the synthesis of GMP from XMP
VAB027_1424	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VAB027_1426	COG1584	GPR1 FUN34 yaaH family protein
VAB027_1427	COG1535	isochorismatase
VAB027_1427	COG3433	isochorismatase activity
VAB027_1428	COG1021	2,3-dihydroxybenzoate-AMP ligase
VAB027_1429	COG1169	isochorismate synthase
VAB027_143	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VAB027_1430	COG1028	Short-chain dehydrogenase reductase Sdr
VAB027_1432	COG4592	Periplasmic binding protein
VAB027_1433	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VAB027_1434	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VAB027_1435	COG1120	ATPase activity
VAB027_1436	COG2977	Belongs to the P-Pant transferase superfamily
VAB027_1437	COG1115	amino acid carrier protein
VAB027_1438	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAB027_144	COG5001	Diguanylate cyclase
VAB027_144	COG3300	MHYT domain
VAB027_1442	COG4565	transcriptional regulatory protein
VAB027_1444	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VAB027_1445	COG5016	pyruvate
VAB027_1445	COG0511	ligase activity, forming carbon-carbon bonds
VAB027_1446	COG3630	sodium ion export across plasma membrane
VAB027_1448	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
VAB027_1449	COG3052	prosthetic group binding
VAB027_1450	COG2301	Belongs to the HpcH HpaI aldolase family
VAB027_1451	COG3051	citrate lyase alpha subunit
VAB027_1452	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
VAB027_1453	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
VAB027_1455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VAB027_1456	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VAB027_1457	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VAB027_146	COG3852	Histidine kinase
VAB027_1460	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VAB027_1461	COG0732	type I restriction modification DNA specificity domain
VAB027_1462	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VAB027_1465	COG1396	sequence-specific DNA binding
VAB027_1474	COG0328	RNA-DNA hybrid ribonuclease activity
VAB027_1477	COG2003	Belongs to the UPF0758 family
VAB027_148	COG0174	glutamine synthetase
VAB027_1489	COG0582	viral genome integration into host DNA
VAB027_1490	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VAB027_1491	COG2867	negative regulation of translational initiation
VAB027_1492	COG2914	Belongs to the UPF0125 (RnfH) family
VAB027_1493	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAB027_1494	COG0497	DNA recombination
VAB027_1495	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VAB027_1496	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VAB027_1497	COG0443	Heat shock 70 kDa protein
VAB027_1498	COG0484	heat shock protein binding
VAB027_15	COG0604	alcohol dehydrogenase
VAB027_1505	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VAB027_1506	COG0590	tRNA wobble adenosine to inosine editing
VAB027_1508	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VAB027_1509	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VAB027_1509	COG0047	phosphoribosylformylglycinamidine synthase activity
VAB027_1513	COG0442	prolyl-tRNA aminoacylation
VAB027_1514	COG1720	tRNA m6t6A37 methyltransferase activity
VAB027_1515	COG0254	rRNA binding
VAB027_1516	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VAB027_1517	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VAB027_1518	COG1671	Belongs to the UPF0178 family
VAB027_1521	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VAB027_1522	COG3385	transposase activity
VAB027_1524	COG3098	single-species biofilm formation
VAB027_1525	COG0564	pseudouridine synthase activity
VAB027_1526	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VAB027_1527	COG0142	geranyltranstransferase activity
VAB027_1528	COG1722	exodeoxyribonuclease VII activity
VAB027_1529	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VAB027_153	COG1490	D-aminoacyl-tRNA deacylase activity
VAB027_1531	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VAB027_1531	COG0301	tRNA thio-modification
VAB027_1532	COG0583	DNA-binding transcription factor activity
VAB027_1533	COG2363	Small membrane protein
VAB027_1534	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VAB027_1535	COG1611	Belongs to the LOG family
VAB027_1536	COG3706	GGDEF domain
VAB027_1538	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VAB027_1538	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VAB027_154	COG0456	acetyltransferase
VAB027_1540	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VAB027_1541	COG1464	Belongs to the NlpA lipoprotein family
VAB027_1542	COG2011	ABC-type metal ion transport system permease component
VAB027_1543	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VAB027_1544	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VAB027_1545	COG1609	Transcriptional regulator
VAB027_1546	COG1263	PTS System
VAB027_1546	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VAB027_1547	COG0366	Alpha amylase catalytic
VAB027_1552	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VAB027_1554	COG2932	Transcriptional regulator
VAB027_1555	COG3423	Transcriptional regulator
VAB027_1556	COG2801	Transposase and inactivated derivatives
VAB027_1557	COG2842	Transposition protein
VAB027_156	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VAB027_157	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VAB027_158	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VAB027_1580	COG0640	Transcriptional regulator
VAB027_1582	COG4373	Mu-like prophage FluMu protein gp28
VAB027_1583	COG4383	Mu-like prophage protein gp29
VAB027_1588	COG4397	Mu-like prophage major head subunit gpT
VAB027_159	COG3031	protein transport across the cell outer membrane
VAB027_1590	COG4387	Mu-like prophage protein GP36
VAB027_1594	COG4386	tail sheath protein
VAB027_1596	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
VAB027_1600	COG4384	Bacteriophage Mu Gp45 protein
VAB027_1602	COG3299	homolog of phage Mu protein gp47
VAB027_1603	COG3778	Protein conserved in bacteria
VAB027_1608	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VAB027_1609	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VAB027_161	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VAB027_1615	COG1045	serine acetyltransferase
VAB027_1617	COG0438	transferase activity, transferring glycosyl groups
VAB027_1619	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
VAB027_162	COG1459	type II secretion system
VAB027_1625	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VAB027_1627	COG1596	polysaccharide export
VAB027_163	COG2165	general secretion pathway protein
VAB027_1632	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VAB027_1634	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VAB027_1635	COG0321	lipoyl(octanoyl) transferase activity
VAB027_1636	COG2921	Belongs to the UPF0250 family
VAB027_1637	COG1686	Belongs to the peptidase S11 family
VAB027_1638	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VAB027_1639	COG0772	Belongs to the SEDS family
VAB027_164	COG2165	general secretion pathway protein
VAB027_1640	COG0768	penicillin binding
VAB027_1641	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VAB027_1642	COG0799	negative regulation of ribosome biogenesis
VAB027_1643	COG1466	dna polymerase III delta subunit
VAB027_1644	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VAB027_1645	COG0495	leucyl-tRNA aminoacylation
VAB027_1646	COG2888	peptidyl-tyrosine sulfation
VAB027_1647	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VAB027_1648	COG4535	Mg2 and Co2 transporter CorC
VAB027_1649	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VAB027_165	COG2165	general secretion pathway protein
VAB027_1650	COG1702	phosphate starvation-inducible protein PhoH
VAB027_1651	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VAB027_1652	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAB027_1653	COG2190	(PTS) system
VAB027_1655	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAB027_1656	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VAB027_1657	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VAB027_1658	COG3115	cell septum assembly
VAB027_1659	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VAB027_166	COG4795	General secretion pathway protein
VAB027_1661	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VAB027_1662	COG0789	Transcriptional regulator
VAB027_1663	COG1585	Membrane protein implicated in regulation of membrane protease activity
VAB027_1664	COG0330	HflC and HflK could
VAB027_1665	COG3118	belongs to the thioredoxin family
VAB027_1666	COG0300	oxidoreductase activity
VAB027_1667	COG1090	epimerase
VAB027_1668	COG0622	Phosphoesterase
VAB027_167	COG3156	type II secretion system protein K
VAB027_1671	COG3710	Transcriptional regulator
VAB027_1672	COG0326	Molecular chaperone. Has ATPase activity
VAB027_1673	COG0563	adenylate kinase activity
VAB027_1674	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VAB027_1677	COG0367	asparagine synthase
VAB027_1678	COG4651	solute:proton antiporter activity
VAB027_1678	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VAB027_1679	COG1940	carbohydrate kinase activity
VAB027_1679	COG1846	Transcriptional regulator
VAB027_168	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VAB027_1680	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VAB027_1681	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VAB027_1681	COG1263	PTS System
VAB027_1681	COG2190	(PTS) system
VAB027_1682	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VAB027_1684	COG0101	tRNA pseudouridine synthase activity
VAB027_1685	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VAB027_1686	COG0285	dihydrofolate synthase activity
VAB027_1687	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VAB027_1688	COG1286	toxin biosynthetic process
VAB027_1689	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VAB027_169	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VAB027_1690	COG2056	Na+-H+ antiporter family
VAB027_1691	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VAB027_1694	COG0346	lactoylglutathione lyase activity
VAB027_1695	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VAB027_1696	COG4660	Part of a membrane complex involved in electron transport
VAB027_1697	COG4659	FMN binding
VAB027_1698	COG4658	electron transport chain
VAB027_1699	COG4656	Part of a membrane complex involved in electron transport
VAB027_17	COG0129	dihydroxy-acid dehydratase activity
VAB027_1700	COG2878	Part of a membrane complex involved in electron transport
VAB027_1701	COG4657	Part of a membrane complex involved in electron transport
VAB027_1703	COG0556	nucleotide-excision repair
VAB027_1704	COG2204	response regulator
VAB027_1705	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VAB027_1706	COG2198	Histidine kinase
VAB027_1707	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VAB027_1708	COG0521	Mo-molybdopterin cofactor biosynthetic process
VAB027_1709	COG0315	cyclic pyranopterin monophosphate synthase activity
VAB027_171	COG1218	3'(2'),5'-bisphosphate nucleotidase
VAB027_1710	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VAB027_1711	COG0314	molybdopterin synthase activity
VAB027_1712	COG2199	diguanylate cyclase activity
VAB027_1713	COG4109	DRTGG domain
VAB027_1715	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VAB027_1717	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VAB027_1717	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VAB027_1718	COG0489	protein tyrosine kinase activity
VAB027_1719	COG0572	uridine kinase
VAB027_172	COG0494	nUDIX hydrolase
VAB027_1720	COG2982	Protein involved in outer membrane biogenesis
VAB027_1721	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VAB027_1722	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VAB027_1724	COG2067	long-chain fatty acid transport protein
VAB027_1727	COG0183	Belongs to the thiolase family
VAB027_1728	COG1024	Enoyl-CoA hydratase
VAB027_1728	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAB027_1729	COG0778	Nitroreductase
VAB027_173	COG0316	Belongs to the HesB IscA family
VAB027_173	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VAB027_1730	COG0583	DNA-binding transcription factor activity
VAB027_1731	COG0745	RESPONSE REGULATOR receiver
VAB027_1733	COG2832	Protein of unknown function (DUF454)
VAB027_1734	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VAB027_1735	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
VAB027_1736	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VAB027_1737	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VAB027_174	COG1040	competence protein
VAB027_1743	COG1028	Short-chain dehydrogenase reductase Sdr
VAB027_1744	COG0616	signal peptide processing
VAB027_1746	COG1522	sequence-specific DNA binding
VAB027_1747	COG1946	Acyl-CoA thioesterase
VAB027_175	COG0596	Alpha beta hydrolase
VAB027_1751	COG3706	GGDEF domain
VAB027_1752	COG0640	Transcriptional regulator
VAB027_1753	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VAB027_1758	COG1881	PFAM PEBP family protein
VAB027_1761	COG0009	L-threonylcarbamoyladenylate synthase
VAB027_1764	COG2201	protein-glutamate methylesterase activity
VAB027_1766	COG5002	protein histidine kinase activity
VAB027_1767	COG4191	Histidine kinase
VAB027_1768	COG3300	MHYT domain
VAB027_1768	COG5001	Diguanylate cyclase
VAB027_1769	COG2204	response regulator
VAB027_177	COG2183	response to ionizing radiation
VAB027_1773	COG0601	transmembrane transport
VAB027_1774	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAB027_1775	COG0444	Belongs to the ABC transporter superfamily
VAB027_1776	COG4608	Belongs to the ABC transporter superfamily
VAB027_1777	COG0435	Glutathione S-transferase
VAB027_1778	COG0280	phosphate acetyltransferase
VAB027_1778	COG0857	belongs to the CobB CobQ family
VAB027_1779	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VAB027_178	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VAB027_1780	COG3092	negative regulation of chromosome organization
VAB027_1781	COG4628	conserved protein (DUF2132)
VAB027_1783	COG4120	Belongs to the binding-protein-dependent transport system permease family
VAB027_1785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VAB027_1786	COG3706	GGDEF domain
VAB027_1787	COG0653	protein targeting
VAB027_1788	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VAB027_1789	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VAB027_179	COG2199	diguanylate cyclase activity
VAB027_1790	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VAB027_1793	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VAB027_1794	COG0156	8-amino-7-oxononanoate synthase activity
VAB027_1795	COG2226	methyltransferase
VAB027_1796	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VAB027_1798	COG0501	Belongs to the peptidase M48B family
VAB027_18	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VAB027_180	COG0745	RESPONSE REGULATOR receiver
VAB027_1800	COG0300	oxidoreductase activity
VAB027_1803	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VAB027_1805	COG2268	Band 7 protein
VAB027_1807	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VAB027_1808	COG2915	High frequency lysogenization protein hflD homolog
VAB027_1809	COG0482	sulfurtransferase activity
VAB027_1810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VAB027_1811	COG2916	Histone family protein nucleoid-structuring protein H-NS
VAB027_1812	COG1757	Na H antiporter
VAB027_1813	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VAB027_1814	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VAB027_1815	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VAB027_1816	COG0131	Imidazoleglycerol-phosphate dehydratase
VAB027_1816	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VAB027_1817	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VAB027_1818	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VAB027_1819	COG0107	imidazoleglycerol-phosphate synthase activity
VAB027_182	COG2233	PERMEase
VAB027_1820	COG0140	phosphoribosyl-ATP diphosphatase activity
VAB027_1820	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VAB027_1821	COG1187	pseudouridine synthase activity
VAB027_1823	COG1278	Cold shock
VAB027_1824	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VAB027_1825	COG0542	response to heat
VAB027_1827	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VAB027_1828	COG1454	alcohol dehydrogenase
VAB027_1828	COG1012	belongs to the aldehyde dehydrogenase family
VAB027_1829	COG1737	Transcriptional regulator
VAB027_183	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VAB027_1830	COG0076	glutamate decarboxylase activity
VAB027_1832	COG2431	L-lysine efflux transmembrane transporter activity
VAB027_1834	COG3070	regulator of competence-specific genes
VAB027_1837	COG3852	Histidine kinase
VAB027_1839	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VAB027_184	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VAB027_1842	COG0189	ligase activity
VAB027_1842	COG4067	protein conserved in archaea
VAB027_1843	COG0500	methyltransferase
VAB027_1844	COG4106	trans-aconitate 2-methyltransferase activity
VAB027_1845	COG1801	Protein of unknown function DUF72
VAB027_1846	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VAB027_1847	COG1435	thymidine kinase activity
VAB027_1849	COG0159	tryptophan synthase activity
VAB027_185	COG1758	RNA polymerase activity
VAB027_1850	COG0133	tryptophan synthase activity
VAB027_1851	COG0134	indole-3-glycerol-phosphate synthase activity
VAB027_1851	COG0135	phosphoribosylanthranilate isomerase activity
VAB027_1854	COG0512	Glutamine amidotransferase of anthranilate synthase
VAB027_1855	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VAB027_1856	COG0613	PHP domain protein
VAB027_1857	COG0009	L-threonylcarbamoyladenylate synthase
VAB027_1858	COG1187	pseudouridine synthase activity
VAB027_1859	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VAB027_186	COG0194	GDP metabolic process
VAB027_1860	COG4988	ABC transporter
VAB027_1861	COG0492	ferredoxin-NADP+ reductase activity
VAB027_1863	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VAB027_1864	COG3706	GGDEF domain
VAB027_1865	COG2949	membrane
VAB027_1867	COG0281	malic enzyme
VAB027_1869	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VAB027_187	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VAB027_1873	COG2885	chlorophyll binding
VAB027_1876	COG0247	lactate metabolic process
VAB027_1876	COG0277	FAD linked oxidase domain protein
VAB027_1881	COG2986	histidine ammonia-lyase
VAB027_1882	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VAB027_1883	COG0010	Belongs to the arginase family
VAB027_1884	COG1228	amidohydrolase
VAB027_1888	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VAB027_1890	COG0417	DNA replication proofreading
VAB027_1891	COG5001	Diguanylate cyclase
VAB027_1892	COG2197	response regulator
VAB027_1893	COG0322	excinuclease ABC activity
VAB027_1899	COG1943	Transposase
VAB027_1901	COG0745	RESPONSE REGULATOR receiver
VAB027_1901	COG3706	GGDEF domain
VAB027_1902	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VAB027_1903	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VAB027_1903	COG0072	phenylalanine-tRNA ligase activity
VAB027_1904	COG0776	regulation of translation
VAB027_1907	COG0500	methyltransferase
VAB027_1908	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VAB027_191	COG3263	regulation of cellular component size
VAB027_1910	COG0295	cytidine deaminase activity
VAB027_1911	COG1346	cytolysis
VAB027_1913	COG2925	Exonuclease
VAB027_1915	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAB027_1916	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VAB027_1917	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VAB027_1920	COG2988	succinylglutamate desuccinylase activity
VAB027_1921	COG4139	cobalamin transport
VAB027_1922	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
VAB027_193	COG4232	protein-disulfide reductase activity
VAB027_1931	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VAB027_1932	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VAB027_1933	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VAB027_1937	COG2814	Major facilitator Superfamily
VAB027_1939	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VAB027_1945	COG3108	Peptidase M15
VAB027_1947	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VAB027_1949	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VAB027_1954	COG1846	Transcriptional regulator
VAB027_1955	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VAB027_1956	COG0726	polysaccharide deacetylase
VAB027_1957	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VAB027_1959	COG1447	Phosphotransferase system cellobiose-specific component IIA
VAB027_1960	COG1486	melibiose metabolic process
VAB027_1961	COG3394	polysaccharide catabolic process
VAB027_1962	COG1609	Transcriptional regulator
VAB027_1963	COG2943	transferase activity, transferring hexosyl groups
VAB027_1964	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
VAB027_1965	COG0840	transmembrane signaling receptor activity
VAB027_1967	COG1943	Transposase
VAB027_1970	COG1448	Aminotransferase
VAB027_1971	COG3437	response regulator, receiver
VAB027_1971	COG2770	Histidine kinase
VAB027_1972	COG0351	phosphomethylpyrimidine kinase
VAB027_1973	COG0017	Asparaginyl-tRNA synthetase
VAB027_1974	COG0840	transmembrane signaling receptor activity
VAB027_1975	COG0720	synthase
VAB027_1976	COG1760	l-serine dehydratase
VAB027_1977	COG0814	amino acid
VAB027_1978	COG0494	nUDIX hydrolase
VAB027_1979	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VAB027_198	COG1027	Aspartate ammonia-lyase
VAB027_1982	COG3106	COG3106 Predicted ATPase
VAB027_1983	COG3768	UPF0283 membrane protein
VAB027_1984	COG3283	Transcriptional regulator of aromatic amino acids metabolism
VAB027_1985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VAB027_1988	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VAB027_199	COG3706	GGDEF domain
VAB027_1990	COG0471	metal ion transport
VAB027_1991	COG4191	Histidine kinase
VAB027_1991	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAB027_1993	COG2990	Protein conserved in bacteria
VAB027_1994	COG3713	MltA-interacting MipA family protein
VAB027_1995	COG5002	protein histidine kinase activity
VAB027_1996	COG0745	RESPONSE REGULATOR receiver
VAB027_2	COG0592	DNA-directed DNA polymerase activity
VAB027_200	COG3030	protein affecting phage T7 exclusion by the F plasmid
VAB027_2001	COG1129	ABC transporter
VAB027_2005	COG1566	PFAM secretion protein HlyD family protein
VAB027_201	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VAB027_2012	COG2186	Transcriptional regulator
VAB027_2013	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VAB027_2015	COG0372	Belongs to the citrate synthase family
VAB027_2021	COG2195	Cleaves the N-terminal amino acid of tripeptides
VAB027_2023	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VAB027_2025	COG3437	response regulator, receiver
VAB027_2026	COG0625	glutathione transferase activity
VAB027_203	COG2205	protein histidine kinase activity
VAB027_2030	COG3706	GGDEF domain
VAB027_2031	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VAB027_2032	COG1254	Belongs to the acylphosphatase family
VAB027_2033	COG2920	part of a sulfur-relay system
VAB027_2034	COG0670	Belongs to the BI1 family
VAB027_2035	COG1126	abc transporter atp-binding protein
VAB027_2036	COG0765	amino acid transport
VAB027_2037	COG4597	amino acid ABC transporter
VAB027_2038	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAB027_204	COG0745	RESPONSE REGULATOR receiver
VAB027_2040	COG0561	phosphatase activity
VAB027_2041	COG0602	queuosine metabolic process
VAB027_2043	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VAB027_2048	COG3706	GGDEF domain
VAB027_2049	COG0443	Heat shock 70 kDa protein
VAB027_2059	COG1643	Atp-dependent helicase
VAB027_206	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VAB027_2063	COG0095	Lipoate-protein ligase
VAB027_2064	COG0402	S-adenosylhomocysteine deaminase activity
VAB027_2065	COG0583	DNA-binding transcription factor activity
VAB027_2066	COG0477	Major facilitator Superfamily
VAB027_2067	COG0415	Belongs to the DNA photolyase family
VAB027_2068	COG2076	Multidrug Resistance protein
VAB027_207	COG0205	6-phosphofructokinase activity
VAB027_2072	COG0643	Histidine kinase
VAB027_2072	COG2198	Histidine kinase
VAB027_2074	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VAB027_2076	COG2201	protein-glutamate methylesterase activity
VAB027_2077	COG0835	chemotaxis
VAB027_2078	COG3290	protein histidine kinase activity
VAB027_2078	COG0840	transmembrane signaling receptor activity
VAB027_2079	COG0840	transmembrane signaling receptor activity
VAB027_2081	COG0513	Belongs to the DEAD box helicase family
VAB027_2083	COG1538	Outer membrane efflux protein
VAB027_2084	COG1566	PFAM secretion protein HlyD family protein
VAB027_2085	COG2814	Major facilitator Superfamily
VAB027_2086	COG0840	transmembrane signaling receptor activity
VAB027_2087	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VAB027_2089	COG3501	Rhs element vgr protein
VAB027_2093	COG1280	lysine exporter protein (LysE YggA)
VAB027_2094	COG1115	amino acid carrier protein
VAB027_2097	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VAB027_2098	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VAB027_2099	COG1177	transmembrane transport
VAB027_21	COG0606	chelatase, subunit chli
VAB027_210	COG3074	FtsZ-dependent cytokinesis
VAB027_2100	COG1176	ABC-type spermidine putrescine transport system, permease component I
VAB027_2101	COG3842	ATPase activity
VAB027_2105	COG0037	tRNA processing
VAB027_2106	COG0589	response to stress
VAB027_2107	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VAB027_211	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VAB027_2110	COG2217	Heavy metal translocating P-type atpase
VAB027_2112	COG2010	Cytochrome c
VAB027_2115	COG3278	Belongs to the heme-copper respiratory oxidase family
VAB027_2118	COG0784	Response regulator, receiver
VAB027_2118	COG2205	protein histidine kinase activity
VAB027_212	COG0527	aspartate kinase activity
VAB027_212	COG0460	homoserine dehydrogenase
VAB027_2123	COG2994	toxin metabolic process
VAB027_2124	COG3064	Membrane
VAB027_2124	COG1073	alpha beta
VAB027_2124	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
VAB027_2127	COG3120	sequence-specific DNA binding
VAB027_2128	COG1067	ATP-dependent peptidase activity
VAB027_2129	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VAB027_213	COG0626	cystathionine gamma-synthase activity
VAB027_2138	COG0167	dihydroorotate dehydrogenase activity
VAB027_214	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
VAB027_2141	COG0308	aminopeptidase N
VAB027_2144	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VAB027_2145	COG1956	GAF domain-containing protein
VAB027_2146	COG1132	(ABC) transporter
VAB027_2147	COG2995	paraquat-inducible protein a
VAB027_2148	COG3008	intermembrane lipid transfer
VAB027_2149	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VAB027_2149	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
VAB027_215	COG0281	malic enzyme
VAB027_2150	COG2996	Protein conserved in bacteria
VAB027_2153	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VAB027_2155	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VAB027_2158	COG0437	4 iron, 4 sulfur cluster binding
VAB027_2159	COG0243	molybdopterin cofactor binding
VAB027_2159	COG3383	formate dehydrogenase (NAD+) activity
VAB027_216	COG0254	rRNA binding
VAB027_2165	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VAB027_2166	COG0488	(ABC) transporter
VAB027_2167	COG3852	Histidine kinase
VAB027_2168	COG2204	response regulator
VAB027_217	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VAB027_2170	COG4662	Binding-protein-dependent transport system inner membrane component
VAB027_2171	COG3842	ATPase activity
VAB027_2172	COG0746	molybdenum cofactor guanylyltransferase activity
VAB027_2173	COG0303	'Molybdopterin
VAB027_2175	COG1940	carbohydrate kinase activity
VAB027_2178	COG0840	transmembrane signaling receptor activity
VAB027_2179	COG0791	NLP P60 protein
VAB027_218	COG1609	Transcriptional regulator
VAB027_2183	COG0534	Mate efflux family protein
VAB027_2185	COG1793	dna ligase
VAB027_2187	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VAB027_2188	COG0848	biopolymer transport protein
VAB027_2189	COG0811	peptide transport
VAB027_219	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VAB027_2190	COG0811	peptide transport
VAB027_2193	COG1175	transmembrane transport
VAB027_2194	COG0395	ABC-type sugar transport system, permease component
VAB027_2195	COG3842	ATPase activity
VAB027_2196	COG1349	DNA-binding transcription factor activity
VAB027_2197	COG0584	glycerophosphoryl diester phosphodiesterase
VAB027_2198	COG2731	YhcH YjgK YiaL family protein
VAB027_2199	COG0251	oxidation-reduction process
VAB027_22	COG0204	Acyl-transferase
VAB027_220	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VAB027_2200	COG1609	Transcriptional regulator
VAB027_2201	COG2723	6-phospho-beta-galactosidase activity
VAB027_2202	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
VAB027_2207	COG0577	efflux transmembrane transporter activity
VAB027_2207	COG1136	(ABC) transporter
VAB027_2208	COG1136	(ABC) transporter
VAB027_2208	COG0577	efflux transmembrane transporter activity
VAB027_2209	COG1136	(ABC) transporter
VAB027_2209	COG4591	ABC-type transport system involved in lipoprotein release permease component
VAB027_221	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VAB027_2210	COG1294	oxidase, subunit
VAB027_2211	COG1271	oxidase subunit
VAB027_222	COG1575	Belongs to the MenA family. Type 1 subfamily
VAB027_2220	COG0583	DNA-binding transcription factor activity
VAB027_2221	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VAB027_2225	COG0753	catalase activity
VAB027_2229	COG0693	protein deglycase activity
VAB027_223	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VAB027_2230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VAB027_2232	COG0346	lactoylglutathione lyase activity
VAB027_2234	COG3527	Alpha-acetolactate decarboxylase
VAB027_2237	COG2200	EAL domain
VAB027_2237	COG2199	diguanylate cyclase activity
VAB027_2238	COG3706	GGDEF domain
VAB027_2239	COG2017	converts alpha-aldose to the beta-anomer
VAB027_2240	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VAB027_2241	COG1085	galactose-1-phosphate uridylyltransferase
VAB027_2246	COG3706	GGDEF domain
VAB027_2246	COG0745	RESPONSE REGULATOR receiver
VAB027_2249	COG0784	Response regulator, receiver
VAB027_2249	COG0835	chemotaxis
VAB027_225	COG0149	triose-phosphate isomerase activity
VAB027_2251	COG4565	transcriptional regulatory protein
VAB027_2252	COG3290	protein histidine kinase activity
VAB027_2255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAB027_2259	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
VAB027_2260	COG3063	Type IV pilus biogenesis stability protein PilW
VAB027_2263	COG1451	nucleotide metabolic process
VAB027_2265	COG0583	DNA-binding transcription factor activity
VAB027_2269	COG1538	Outer membrane efflux protein
VAB027_2271	COG0019	diaminopimelate decarboxylase activity
VAB027_2272	COG1748	Saccharopine dehydrogenase
VAB027_2274	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VAB027_2277	COG4181	ATPase activity
VAB027_2278	COG0534	Mate efflux family protein
VAB027_2279	COG0702	epimerase
VAB027_2281	COG2814	Major facilitator Superfamily
VAB027_2282	COG1187	pseudouridine synthase activity
VAB027_2283	COG1061	Type III restriction enzyme res subunit
VAB027_2286	COG5002	protein histidine kinase activity
VAB027_2287	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VAB027_2288	COG5001	Diguanylate cyclase
VAB027_2288	COG4251	negative regulation of phosphorylation
VAB027_2288	COG2203	Gaf domain
VAB027_2288	COG3706	GGDEF domain
VAB027_2290	COG0840	transmembrane signaling receptor activity
VAB027_2293	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
VAB027_2297	COG4934	collagen metabolic process
VAB027_23	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VAB027_230	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VAB027_2301	COG2239	Acts as a magnesium transporter
VAB027_2304	COG0814	amino acid
VAB027_2305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAB027_2306	COG1131	(ABC) transporter
VAB027_2307	COG0842	Transport permease protein
VAB027_2309	COG3313	Fe-S protein
VAB027_231	COG0459	protein refolding
VAB027_2311	COG4134	Bacterial extracellular solute-binding protein
VAB027_2312	COG4135	transport system, permease component
VAB027_2313	COG4136	ATPase activity
VAB027_2314	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VAB027_2315	COG0564	pseudouridine synthase activity
VAB027_2316	COG0733	neurotransmitter:sodium symporter activity
VAB027_2318	COG0626	cystathionine gamma-synthase activity
VAB027_2319	COG2818	Glycosylase
VAB027_2322	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAB027_2325	COG1842	Phage shock protein A
VAB027_2326	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VAB027_2329	COG4168	peptide transport system, permease
VAB027_233	COG1509	lysine 2,3-aminomutase activity
VAB027_2330	COG4171	peptide transport system, permease
VAB027_2332	COG4172	Belongs to the ABC transporter superfamily
VAB027_2335	COG1227	inorganic diphosphatase activity
VAB027_2338	COG0243	molybdopterin cofactor binding
VAB027_2339	COG3005	denitrification pathway
VAB027_234	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VAB027_2340	COG4459	periplasmic nitrate reductase
VAB027_2341	COG2116	formate transmembrane transporter activity
VAB027_2343	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VAB027_2344	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VAB027_2346	COG2917	probably involved in intracellular septation
VAB027_2347	COG1607	acyl-coa hydrolase
VAB027_2348	COG2350	Protein conserved in bacteria
VAB027_235	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VAB027_2350	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VAB027_2351	COG0583	DNA-binding transcription factor activity
VAB027_2354	COG0612	Peptidase, M16
VAB027_2355	COG5001	Diguanylate cyclase
VAB027_2356	COG1032	radical SAM domain protein
VAB027_2357	COG1280	lysine exporter protein (LysE YggA)
VAB027_2359	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VAB027_236	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VAB027_2360	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VAB027_2361	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
VAB027_2362	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VAB027_2363	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VAB027_2364	COG0745	RESPONSE REGULATOR receiver
VAB027_2366	COG1609	Transcriptional regulator
VAB027_2367	COG3070	regulator of competence-specific genes
VAB027_237	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VAB027_2371	COG0297	glycogen (starch) synthase activity
VAB027_2372	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VAB027_2373	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VAB027_2375	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VAB027_2376	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VAB027_2377	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VAB027_2378	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VAB027_2379	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VAB027_238	COG1053	succinate dehydrogenase
VAB027_2380	COG1960	acyl-CoA dehydrogenase activity
VAB027_2383	COG1012	belongs to the aldehyde dehydrogenase family
VAB027_2385	COG1309	transcriptional regulator
VAB027_2386	COG2995	paraquat-inducible protein a
VAB027_2387	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VAB027_2387	COG3008	intermembrane lipid transfer
VAB027_2389	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAB027_239	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VAB027_2392	COG0582	viral genome integration into host DNA
VAB027_24	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VAB027_240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VAB027_2407	COG4790	Type iii secretion
VAB027_2409	COG3710	Transcriptional regulator
VAB027_241	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VAB027_2415	COG4792	protein secretion
VAB027_2416	COG4789	Type iii secretion
VAB027_242	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VAB027_243	COG1045	serine acetyltransferase
VAB027_2437	COG3064	Membrane
VAB027_2439	COG0596	Alpha beta hydrolase
VAB027_2444	COG5492	domain, Protein
VAB027_2444	COG4932	domain protein
VAB027_2446	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
VAB027_2447	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
VAB027_2448	COG1737	Transcriptional regulator
VAB027_2449	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VAB027_245	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VAB027_2450	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VAB027_2451	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VAB027_2452	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAB027_2453	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
VAB027_2454	COG1940	carbohydrate kinase activity
VAB027_2455	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VAB027_2456	COG4409	exo-alpha-(2->6)-sialidase activity
VAB027_246	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VAB027_2462	COG1401	restriction endodeoxyribonuclease activity
VAB027_2465	COG5001	Diguanylate cyclase
VAB027_2467	COG0415	Belongs to the DNA photolyase family
VAB027_2469	COG4628	conserved protein (DUF2132)
VAB027_247	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VAB027_2470	COG3284	Transcriptional regulator
VAB027_2471	COG1012	belongs to the aldehyde dehydrogenase family
VAB027_2473	COG5002	protein histidine kinase activity
VAB027_2473	COG0784	Response regulator, receiver
VAB027_2475	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VAB027_2477	COG2885	chlorophyll binding
VAB027_2478	COG0823	Involved in the tonB-independent uptake of proteins
VAB027_248	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VAB027_2481	COG0811	peptide transport
VAB027_2482	COG0824	Thioesterase
VAB027_2483	COG3790	cyd operon protein YbgE
VAB027_2484	COG4890	Cyd operon protein YbgT
VAB027_2485	COG1294	oxidase, subunit
VAB027_2486	COG1271	oxidase subunit
VAB027_2487	COG2255	four-way junction helicase activity
VAB027_2489	COG0632	four-way junction helicase activity
VAB027_249	COG0137	argininosuccinate synthase activity
VAB027_2490	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VAB027_2491	COG0215	cysteine-tRNA ligase activity
VAB027_2492	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VAB027_2493	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VAB027_2494	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VAB027_2496	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VAB027_2497	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VAB027_2498	COG1199	ATP-dependent helicase activity
VAB027_2499	COG0730	response to heat
VAB027_250	COG0165	Argininosuccinate lyase
VAB027_2500	COG3923	Primosomal replication protein n
VAB027_2502	COG0840	transmembrane signaling receptor activity
VAB027_2503	COG0708	Exodeoxyribonuclease III
VAB027_2504	COG4160	amino acid transport
VAB027_2505	COG4215	(ABC) transporter
VAB027_2511	COG1882	Formate acetyltransferase
VAB027_2513	COG0840	transmembrane signaling receptor activity
VAB027_2514	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VAB027_2516	COG3013	Belongs to the UPF0304 family
VAB027_2517	COG2766	serine protein kinase
VAB027_2518	COG2718	Belongs to the UPF0229 family
VAB027_2519	COG2719	SpoVR family
VAB027_252	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VAB027_2520	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VAB027_2522	COG1663	tetraacyldisaccharide 4'-kinase activity
VAB027_2523	COG1132	(ABC) transporter
VAB027_2524	COG2333	competence protein COMEC
VAB027_2524	COG0658	competence protein
VAB027_2526	COG4591	ABC-type transport system involved in lipoprotein release permease component
VAB027_2527	COG1136	(ABC) transporter
VAB027_2528	COG4591	ABC-type transport system involved in lipoprotein release permease component
VAB027_253	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VAB027_253	COG0678	peroxiredoxin activity
VAB027_2530	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VAB027_2534	COG1252	NADH dehydrogenase
VAB027_2541	COG0537	adenosine 5'-monophosphoramidase activity
VAB027_2545	COG2186	Transcriptional regulator
VAB027_2546	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VAB027_2547	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VAB027_2548	COG1674	ftsk spoiiie
VAB027_255	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VAB027_2550	COG0686	Belongs to the AlaDH PNT family
VAB027_2552	COG0583	DNA-binding transcription factor activity
VAB027_2555	COG0284	orotidine-5'-phosphate decarboxylase activity
VAB027_2556	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VAB027_2557	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VAB027_2558	COG0776	regulation of translation
VAB027_2559	COG0539	negative regulation of cytoplasmic translation
VAB027_2560	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VAB027_2561	COG1555	photosystem II stabilization
VAB027_2562	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VAB027_2563	COG0776	regulation of translation
VAB027_2564	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VAB027_2565	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VAB027_2567	COG0544	peptidyl-prolyl cis-trans isomerase activity
VAB027_2568	COG4191	Histidine kinase
VAB027_2570	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VAB027_2571	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VAB027_2572	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAB027_2573	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VAB027_2576	COG5001	Diguanylate cyclase
VAB027_2576	COG3300	MHYT domain
VAB027_2578	COG4589	Belongs to the CDS family
VAB027_2585	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VAB027_2587	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAB027_2590	COG0243	molybdopterin cofactor binding
VAB027_2591	COG3005	denitrification pathway
VAB027_2592	COG3469	chitinase activity
VAB027_2592	COG3325	Belongs to the glycosyl hydrolase 18 family
VAB027_2593	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VAB027_2595	COG2951	lytic endotransglycosylase activity
VAB027_2596	COG3100	YcgL domain-containing protein
VAB027_2597	COG0850	regulation of cytokinetic process
VAB027_2598	COG2894	cell division
VAB027_2599	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VAB027_26	COG3084	Protein conserved in bacteria
VAB027_2600	COG3015	lipoprotein NlpE involved in copper resistance
VAB027_2606	COG3135	benzoate transporter
VAB027_2608	COG1441	menaquinone biosynthetic process
VAB027_261	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VAB027_2610	COG0596	Alpha beta hydrolase
VAB027_2611	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VAB027_2612	COG1169	isochorismate synthase
VAB027_2613	COG0436	Aminotransferase
VAB027_2614	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VAB027_2616	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VAB027_2619	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VAB027_262	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VAB027_2620	COG0318	PFAM AMP-dependent synthetase and ligase
VAB027_2621	COG0596	Alpha beta hydrolase
VAB027_2624	COG1214	PFAM Peptidase M22, glycoprotease
VAB027_2625	COG1199	ATP-dependent helicase activity
VAB027_2627	COG0788	formyltetrahydrofolate deformylase activity
VAB027_2628	COG1902	pentaerythritol trinitrate reductase activity
VAB027_2628	COG0446	pyridine nucleotide-disulphide oxidoreductase
VAB027_2629	COG0616	signal peptide processing
VAB027_2630	COG0252	asparaginase activity
VAB027_2631	COG3139	Protein of unknown function (DUF1315)
VAB027_2633	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAB027_2634	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VAB027_2635	COG0676	glucose-6-phosphate 1-epimerase activity
VAB027_2637	COG2226	methyltransferase
VAB027_264	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VAB027_2640	COG0835	chemotaxis
VAB027_2640	COG0784	Response regulator, receiver
VAB027_2641	COG1940	carbohydrate kinase activity
VAB027_2643	COG4667	esterase of the alpha-beta hydrolase superfamily
VAB027_2646	COG0733	neurotransmitter:sodium symporter activity
VAB027_2649	COG3385	transposase activity
VAB027_265	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VAB027_2650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VAB027_2650	COG1263	PTS System
VAB027_2651	COG0084	hydrolase, TatD family'
VAB027_2653	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VAB027_2654	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VAB027_2655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VAB027_2656	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VAB027_2657	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VAB027_2658	COG1028	Short-chain dehydrogenase reductase Sdr
VAB027_2659	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
VAB027_266	COG0546	phosphoglycolate phosphatase activity
VAB027_2660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VAB027_2661	COG0416	fatty acid biosynthetic process
VAB027_2662	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VAB027_2663	COG1399	metal-binding, possibly nucleic acid-binding protein
VAB027_2664	COG0424	maF-like protein
VAB027_2665	COG0564	pseudouridine synthase activity
VAB027_2667	COG1530	ribonuclease E activity
VAB027_2668	COG0659	secondary active sulfate transmembrane transporter activity
VAB027_267	COG0180	Tryptophanyl-tRNA synthetase
VAB027_2670	COG1012	belongs to the aldehyde dehydrogenase family
VAB027_2670	COG1454	alcohol dehydrogenase
VAB027_2671	COG2095	MarC family integral membrane protein
VAB027_2672	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VAB027_2673	COG1757	Na H antiporter
VAB027_2675	COG3081	Nucleoid-associated protein
VAB027_2677	COG3083	sulfuric ester hydrolase activity
VAB027_2680	COG0123	including yeast histone deacetylase and acetoin utilization protein
VAB027_2681	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VAB027_2682	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VAB027_2686	COG2853	Lipoprotein
VAB027_2688	COG3088	subunit of a heme lyase
VAB027_2688	COG4235	cytochrome complex assembly
VAB027_2689	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VAB027_2690	COG1138	Cytochrome C-type biogenesis protein
VAB027_2691	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VAB027_2693	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VAB027_2694	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VAB027_2695	COG4133	protoheme IX ABC transporter activity
VAB027_2697	COG0835	chemotaxis
VAB027_2699	COG1192	Involved in chromosome partitioning
VAB027_27	COG4326	sporulation control protein
VAB027_270	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VAB027_2700	COG2201	protein-glutamate methylesterase activity
VAB027_2701	COG0643	Histidine kinase
VAB027_2701	COG2198	Histidine kinase
VAB027_2702	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VAB027_2705	COG0455	bacterial-type flagellum organization
VAB027_2708	COG2062	phosphohistidine phosphatase, SixA
VAB027_2710	COG1025	Belongs to the peptidase M16 family
VAB027_2711	COG0018	arginyl-trna synthetase
VAB027_2715	COG1918	ferrous iron import across plasma membrane
VAB027_2716	COG4977	sequence-specific DNA binding
VAB027_2717	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VAB027_2718	COG1121	(ABC) transporter
VAB027_2719	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VAB027_272	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VAB027_2721	COG0045	succinate-CoA ligase (ADP-forming) activity
VAB027_2722	COG0508	dehydrogenase complex catalyzes the overall conversion of
VAB027_2723	COG0567	Dehydrogenase, E1 component
VAB027_2725	COG1053	succinate dehydrogenase
VAB027_2726	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VAB027_2727	COG2009	succinate dehydrogenase
VAB027_2728	COG0372	Belongs to the citrate synthase family
VAB027_2729	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VAB027_2731	COG0033	Phosphoglucomutase
VAB027_2732	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VAB027_2733	COG0596	Alpha beta hydrolase
VAB027_2738	COG0583	DNA-binding transcription factor activity
VAB027_2740	COG0735	belongs to the Fur family
VAB027_2741	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VAB027_2742	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAB027_2743	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VAB027_2744	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VAB027_2744	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAB027_2745	COG0431	NADPH-dependent FMN reductase
VAB027_2747	COG3101	peptidyl-lysine hydroxylation
VAB027_2748	COG2860	membrane
VAB027_2749	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VAB027_2750	COG2890	protein-(glutamine-N5) methyltransferase activity
VAB027_2753	COG1684	flagellar biosynthetic protein fliR
VAB027_2754	COG1987	bacterial-type flagellum assembly
VAB027_2759	COG1580	Controls the rotational direction of flagella during chemotaxis
VAB027_276	COG3385	transposase activity
VAB027_2763	COG1317	bacterial-type flagellum organization
VAB027_2764	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VAB027_2766	COG1677	Flagellar hook-basal body complex protein FliE
VAB027_2767	COG2204	response regulator
VAB027_2768	COG4191	Histidine kinase
VAB027_2769	COG2204	response regulator
VAB027_2770	COG1516	flagellar protein fliS
VAB027_2772	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VAB027_2773	COG1334	flagellar protein FlaG
VAB027_2774	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VAB027_2775	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VAB027_2776	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VAB027_2777	COG2837	iron assimilation
VAB027_2781	COG1393	Belongs to the ArsC family
VAB027_2782	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VAB027_2783	COG1876	peptidase activity
VAB027_2785	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VAB027_2786	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VAB027_2788	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VAB027_2792	COG4783	chaperone-mediated protein folding
VAB027_2793	COG1393	Belongs to the ArsC family
VAB027_2796	COG1943	Transposase
VAB027_2798	COG2233	PERMEase
VAB027_2799	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VAB027_28	COG1272	protein, Hemolysin III
VAB027_2800	COG0737	Belongs to the 5'-nucleotidase family
VAB027_2801	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VAB027_2802	COG2912	Transglutaminase-like superfamily
VAB027_2803	COG3094	Invasion gene expression up-regulator, SirB
VAB027_2804	COG2890	protein-(glutamine-N5) methyltransferase activity
VAB027_2805	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VAB027_2806	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VAB027_2807	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
VAB027_2808	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VAB027_2809	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VAB027_2810	COG0193	aminoacyl-tRNA hydrolase activity
VAB027_2811	COG0012	GTP binding
VAB027_2830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VAB027_2831	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VAB027_2834	COG1705	Flagellar rod assembly protein muramidase FlgJ
VAB027_2834	COG3951	Flagellar rod assembly protein muramidase FlgJ
VAB027_2835	COG1706	bacterial-type flagellum-dependent cell motility
VAB027_2836	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VAB027_2837	COG4786	Flagellar basal body rod
VAB027_2838	COG4787	bacterial-type flagellum-dependent cell motility
VAB027_2839	COG1749	Flagellar hook protein flgE
VAB027_2840	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
VAB027_2841	COG1558	bacterial-type flagellum-dependent cell motility
VAB027_2842	COG1815	bacterial-type flagellum-dependent cell motility
VAB027_2843	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VAB027_2844	COG0835	chemotaxis
VAB027_2844	COG0784	Response regulator, receiver
VAB027_2851	COG3433	isochorismatase activity
VAB027_2851	COG2226	methyltransferase
VAB027_2851	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VAB027_2852	COG2375	cellular response to nickel ion
VAB027_2853	COG4774	siderophore transport
VAB027_2853	COG1629	transport
VAB027_2856	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VAB027_2857	COG2608	mercury ion transmembrane transporter activity
VAB027_2857	COG2217	Heavy metal translocating P-type atpase
VAB027_2864	COG2840	Smr protein MutS2
VAB027_2865	COG1187	pseudouridine synthase activity
VAB027_2867	COG3706	GGDEF domain
VAB027_2868	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VAB027_2869	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VAB027_2870	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VAB027_2871	COG0121	glutamine amidotransferase
VAB027_2872	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VAB027_2873	COG1960	acyl-CoA dehydrogenase activity
VAB027_2875	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VAB027_2876	COG0328	RNA-DNA hybrid ribonuclease activity
VAB027_2877	COG2226	methyltransferase
VAB027_2878	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VAB027_2879	COG0741	lytic transglycosylase activity
VAB027_2879	COG1388	LysM domain
VAB027_2881	COG0347	Belongs to the P(II) protein family
VAB027_2882	COG3479	Phenolic acid decarboxylase
VAB027_2884	COG0037	tRNA processing
VAB027_2885	COG0825	malonyl-CoA metabolic process
VAB027_2886	COG0587	DNA-directed DNA polymerase activity
VAB027_2887	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VAB027_2888	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VAB027_2889	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VAB027_2890	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VAB027_2891	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VAB027_2892	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VAB027_2894	COG0750	zinc metalloprotease
VAB027_2895	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VAB027_2896	COG0575	Belongs to the CDS family
VAB027_2897	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VAB027_2898	COG0233	cytoplasmic translational termination
VAB027_2899	COG0528	UMP kinase activity
VAB027_2900	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VAB027_2901	COG0052	Belongs to the universal ribosomal protein uS2 family
VAB027_2902	COG0024	Methionine aminopeptidase
VAB027_2903	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VAB027_2905	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VAB027_2906	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VAB027_2907	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VAB027_2908	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VAB027_2911	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VAB027_2911	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VAB027_2912	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VAB027_2913	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VAB027_2914	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VAB027_2917	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VAB027_2918	COG2252	PERMEase
VAB027_2919	COG2195	Cleaves the N-terminal amino acid of tripeptides
VAB027_2920	COG4067	protein conserved in archaea
VAB027_2920	COG0189	ligase activity
VAB027_2921	COG0189	ligase activity
VAB027_2923	COG0733	neurotransmitter:sodium symporter activity
VAB027_2924	COG3706	GGDEF domain
VAB027_2926	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VAB027_2928	COG1477	protein flavinylation
VAB027_2929	COG2871	sodium ion transport
VAB027_2930	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VAB027_2931	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VAB027_2932	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VAB027_2933	COG1805	sodium ion transport
VAB027_2934	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VAB027_2935	COG0271	Belongs to the BolA IbaG family
VAB027_2936	COG2813	Specifically methylates the guanine in position
VAB027_2938	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VAB027_2939	COG2211	Major facilitator Superfamily
VAB027_2941	COG1595	DNA-templated transcription, initiation
VAB027_2943	COG3248	Nucleoside-binding outer membrane protein
VAB027_2944	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VAB027_2945	COG0693	protein deglycase activity
VAB027_2946	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VAB027_2947	COG2166	iron-sulfur cluster assembly
VAB027_2948	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VAB027_2949	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VAB027_2951	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VAB027_2951	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VAB027_2953	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VAB027_2954	COG1074	ATP-dependent DNA helicase activity
VAB027_2956	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VAB027_2959	COG3141	response to X-ray
VAB027_2960	COG2171	N-acyltransferase activity
VAB027_2962	COG0456	acetyltransferase
VAB027_2964	COG0569	domain protein
VAB027_2964	COG0189	ligase activity
VAB027_2966	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VAB027_2968	COG3250	beta-galactosidase activity
VAB027_2969	COG1609	Transcriptional regulator
VAB027_2972	COG1022	Amp-dependent synthetase and ligase
VAB027_2973	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VAB027_2974	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VAB027_2976	COG0560	Phosphoserine phosphatase
VAB027_2978	COG0813	purine-nucleoside phosphorylase activity
VAB027_2979	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VAB027_2980	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VAB027_2981	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VAB027_2982	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VAB027_2983	COG0084	hydrolase, TatD family'
VAB027_2986	COG1115	amino acid carrier protein
VAB027_2989	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VAB027_2990	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VAB027_2991	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VAB027_2992	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VAB027_2993	COG0083	homoserine kinase activity
VAB027_2995	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VAB027_2998	COG0745	RESPONSE REGULATOR receiver
VAB027_2999	COG0784	Response regulator, receiver
VAB027_2999	COG2198	Histidine kinase
VAB027_2999	COG5002	protein histidine kinase activity
VAB027_3	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VAB027_30	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VAB027_3000	COG2203	Gaf domain
VAB027_3000	COG3706	GGDEF domain
VAB027_3000	COG4251	negative regulation of phosphorylation
VAB027_3000	COG5001	Diguanylate cyclase
VAB027_3001	COG1242	4 iron, 4 sulfur cluster binding
VAB027_3005	COG0069	glutamate synthase activity
VAB027_3005	COG0067	glutamate synthase
VAB027_3005	COG0070	glutamate synthase
VAB027_3006	COG0493	'glutamate synthase
VAB027_3008	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VAB027_301	COG0557	exoribonuclease II activity
VAB027_3010	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VAB027_3011	COG2860	membrane
VAB027_3012	COG0730	response to heat
VAB027_3013	COG0583	DNA-binding transcription factor activity
VAB027_3017	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VAB027_3018	COG0505	Belongs to the CarA family
VAB027_3019	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VAB027_302	COG1278	Cold shock
VAB027_3020	COG0494	nUDIX hydrolase
VAB027_3021	COG0653	protein targeting
VAB027_3023	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VAB027_3024	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VAB027_3025	COG0849	cell division
VAB027_3026	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VAB027_3027	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VAB027_3028	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VAB027_3029	COG0772	Belongs to the SEDS family
VAB027_3030	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VAB027_3031	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VAB027_3032	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VAB027_3033	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VAB027_3034	COG0768	penicillin binding
VAB027_3035	COG3116	cell division
VAB027_3036	COG0275	rRNA processing
VAB027_3037	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VAB027_3038	COG0508	dehydrogenase complex catalyzes the overall conversion of
VAB027_3039	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VAB027_3040	COG2186	Transcriptional regulator
VAB027_3041	COG0737	Belongs to the 5'-nucleotidase family
VAB027_3042	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VAB027_3043	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VAB027_3044	COG4974	Belongs to the 'phage' integrase family
VAB027_3045	COG0716	FMN binding
VAB027_3050	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VAB027_3051	COG1459	type II secretion system
VAB027_3053	COG0237	dephospho-CoA kinase activity
VAB027_3054	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VAB027_3055	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VAB027_3056	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VAB027_3057	COG0187	DNA topoisomerase II activity
VAB027_3058	COG3150	esterase
VAB027_3060	COG3151	Protein conserved in bacteria
VAB027_3061	COG0494	nUDIX hydrolase
VAB027_3062	COG1538	Outer membrane efflux protein
VAB027_3063	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VAB027_3063	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VAB027_3064	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VAB027_3065	COG0840	transmembrane signaling receptor activity
VAB027_3067	COG3025	triphosphatase activity
VAB027_3068	COG1392	Phosphate transport regulator
VAB027_3069	COG0306	phosphate transporter
VAB027_3070	COG4991	sh3 domain protein
VAB027_3072	COG3409	Peptidoglycan-binding domain 1 protein
VAB027_3072	COG3267	Type II secretory pathway component ExeA
VAB027_3073	COG0617	tRNA 3'-terminal CCA addition
VAB027_3074	COG0148	phosphopyruvate hydratase activity
VAB027_3075	COG0504	CTP synthase activity
VAB027_3076	COG3956	TIGRFAM MazG family protein
VAB027_3077	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VAB027_3078	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VAB027_3083	COG0736	holo-[acyl-carrier-protein] synthase activity
VAB027_3084	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VAB027_3085	COG1381	Involved in DNA repair and RecF pathway recombination
VAB027_3086	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VAB027_3087	COG0571	ribonuclease III activity
VAB027_3088	COG0681	Belongs to the peptidase S26 family
VAB027_3089	COG0481	GTPase activity
VAB027_3090	COG3086	response to oxidative stress
VAB027_3091	COG3026	antisigma factor binding
VAB027_3093	COG1595	DNA-templated transcription, initiation
VAB027_3094	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VAB027_3096	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VAB027_3097	COG0354	folic acid binding
VAB027_3099	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAB027_31	COG0569	domain protein
VAB027_3100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAB027_3102	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VAB027_3103	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VAB027_3104	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VAB027_3105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAB027_3106	COG0440	acetolactate synthase activity
VAB027_3107	COG0028	Belongs to the TPP enzyme family
VAB027_3108	COG1022	Amp-dependent synthetase and ligase
VAB027_3109	COG0583	DNA-binding transcription factor activity
VAB027_3112	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VAB027_3113	COG0473	3-isopropylmalate dehydrogenase activity
VAB027_3114	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VAB027_3115	COG0066	3-isopropylmalate dehydratase activity
VAB027_3124	COG0542	response to heat
VAB027_3126	COG0564	pseudouridine synthase activity
VAB027_3127	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAB027_3128	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VAB027_3129	COG1605	Chorismate mutase
VAB027_3129	COG0077	Prephenate dehydratase
VAB027_313	COG0583	DNA-binding transcription factor activity
VAB027_3130	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VAB027_3131	COG5001	Diguanylate cyclase
VAB027_3132	COG3941	tape measure
VAB027_314	COG3048	D-serine ammonia-lyase activity
VAB027_3140	COG0488	(ABC) transporter
VAB027_3147	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VAB027_3148	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VAB027_3150	COG0488	(ABC) transporter
VAB027_3152	COG1605	Chorismate mutase
VAB027_3152	COG0287	Prephenate dehydrogenase
VAB027_3153	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VAB027_3154	COG3275	phosphorelay sensor kinase activity
VAB027_3155	COG3279	Response regulator of the LytR AlgR family
VAB027_3156	COG1472	Belongs to the glycosyl hydrolase 3 family
VAB027_3157	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VAB027_3158	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VAB027_316	COG1278	Cold shock
VAB027_3161	COG1966	Carbon starvation protein
VAB027_3162	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VAB027_3163	COG1047	Peptidyl-prolyl cis-trans
VAB027_3164	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VAB027_3165	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VAB027_3166	COG0196	riboflavin kinase activity
VAB027_3167	COG0728	peptidoglycan biosynthetic process
VAB027_3168	COG0268	Binds directly to 16S ribosomal RNA
VAB027_3169	COG0640	Transcriptional regulator
VAB027_3170	COG0583	DNA-binding transcription factor activity
VAB027_3171	COG1283	sodium-dependent phosphate transmembrane transporter activity
VAB027_3172	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VAB027_3173	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VAB027_3174	COG0730	response to heat
VAB027_3175	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
VAB027_3176	COG0494	nUDIX hydrolase
VAB027_3177	COG3066	DNA modification
VAB027_3178	COG0667	Aldo Keto reductase
VAB027_318	COG0557	exoribonuclease II activity
VAB027_3180	COG2204	response regulator
VAB027_3181	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VAB027_3182	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VAB027_3184	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VAB027_3187	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VAB027_319	COG0557	exoribonuclease II activity
VAB027_3191	COG3153	acetyltransferase
VAB027_3198	COG4785	May be involved in cell division
VAB027_3199	COG1185	polyribonucleotide nucleotidyltransferase activity
VAB027_32	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VAB027_32	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VAB027_320	COG1686	Belongs to the peptidase S11 family
VAB027_3200	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VAB027_3201	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VAB027_3202	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VAB027_3203	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VAB027_3204	COG0195	Participates in both transcription termination and antitermination
VAB027_3205	COG0779	Required for maturation of 30S ribosomal subunits
VAB027_3208	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VAB027_3210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VAB027_3211	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VAB027_3212	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VAB027_3213	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VAB027_3214	COG1534	Rna-binding protein
VAB027_3215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VAB027_3217	COG2027	D-alanyl-D-alanine carboxypeptidase
VAB027_3218	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VAB027_3219	COG0739	heme binding
VAB027_3220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VAB027_3222	COG0316	Belongs to the HesB IscA family
VAB027_3223	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VAB027_3225	COG0628	permease
VAB027_3226	COG2813	Specifically methylates the guanine in position
VAB027_3228	COG0747	negative chemotaxis
VAB027_3229	COG0601	transmembrane transport
VAB027_323	COG3047	cAMP biosynthetic process
VAB027_3230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAB027_3231	COG0444	Belongs to the ABC transporter superfamily
VAB027_3232	COG4608	Belongs to the ABC transporter superfamily
VAB027_3234	COG2971	BadF BadG BcrA BcrD
VAB027_3238	COG3842	ATPase activity
VAB027_324	COG3227	Zinc metalloprotease (Elastase)
VAB027_3240	COG1840	ABC-type Fe3 transport system, periplasmic component
VAB027_3241	COG0004	ammonium transporteR
VAB027_3242	COG0347	Belongs to the P(II) protein family
VAB027_3243	COG3112	Uncharacterised protein family (UPF0231)
VAB027_3244	COG1049	propionate catabolic process, 2-methylcitrate cycle
VAB027_3245	COG1752	Esterase of the alpha-beta hydrolase superfamily
VAB027_3246	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VAB027_3247	COG1643	Atp-dependent helicase
VAB027_3249	COG1489	DNA binding
VAB027_3250	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VAB027_3251	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VAB027_3253	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VAB027_3254	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VAB027_3255	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VAB027_3256	COG0842	Transport permease protein
VAB027_3257	COG1131	(ABC) transporter
VAB027_3258	COG0659	secondary active sulfate transmembrane transporter activity
VAB027_3259	COG0288	reversible hydration of carbon dioxide
VAB027_3262	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VAB027_3263	COG3107	peptidoglycan biosynthetic process
VAB027_3264	COG0792	nuclease activity
VAB027_3265	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VAB027_3266	COG2823	Periplasmic or secreted lipoprotein
VAB027_3267	COG2969	positive regulation of protein catabolic process
VAB027_3268	COG0625	glutathione transferase activity
VAB027_3269	COG2857	Cytochrome c1
VAB027_3270	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VAB027_3271	COG0723	plastoquinol--plastocyanin reductase activity
VAB027_3272	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VAB027_3273	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VAB027_3274	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VAB027_3276	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VAB027_3277	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VAB027_3278	COG0335	large ribosomal subunit rRNA binding
VAB027_3279	COG0336	Belongs to the RNA methyltransferase TrmD family
VAB027_328	COG2267	carboxylic ester hydrolase activity
VAB027_3280	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VAB027_3281	COG0228	four-way junction DNA binding
VAB027_3282	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VAB027_3284	COG4137	Cytochrome C assembly protein
VAB027_3285	COG4536	flavin adenine dinucleotide binding
VAB027_3286	COG1854	S-ribosylhomocysteine lyase activity
VAB027_3287	COG2918	glutathione biosynthetic process
VAB027_3288	COG0612	Peptidase, M16
VAB027_3289	COG1238	metal cluster binding
VAB027_329	COG2067	long-chain fatty acid transport protein
VAB027_3291	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VAB027_3292	COG0511	ligase activity, forming carbon-carbon bonds
VAB027_3292	COG5016	pyruvate
VAB027_3293	COG3630	sodium ion export across plasma membrane
VAB027_33	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VAB027_330	COG0366	Alpha amylase catalytic
VAB027_3302	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
VAB027_3303	COG0527	aspartate kinase activity
VAB027_3304	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VAB027_3305	COG2137	regulation of response to DNA damage stimulus
VAB027_3306	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VAB027_3308	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
VAB027_3309	COG4208	sulfate ABC transporter
VAB027_331	COG4989	oxidoreductase activity
VAB027_3315	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VAB027_3316	COG4942	peptidase
VAB027_3316	COG1388	LysM domain
VAB027_3317	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VAB027_3318	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VAB027_3319	COG0585	pseudouridine synthase activity
VAB027_3320	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VAB027_3321	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VAB027_3322	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VAB027_3323	COG1968	undecaprenyl-diphosphatase activity
VAB027_3324	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VAB027_3325	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VAB027_3326	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VAB027_3328	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VAB027_3329	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VAB027_333	COG1136	(ABC) transporter
VAB027_3330	COG1610	YqeY-like protein
VAB027_3331	COG0358	DNA primase activity
VAB027_3332	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VAB027_3335	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VAB027_3336	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VAB027_3337	COG1349	DNA-binding transcription factor activity
VAB027_3338	COG0469	pyruvate kinase activity
VAB027_334	COG1136	(ABC) transporter
VAB027_334	COG0577	efflux transmembrane transporter activity
VAB027_3342	COG0583	DNA-binding transcription factor activity
VAB027_3343	COG1279	arginine transmembrane transporter activity
VAB027_3344	COG0668	transmembrane transport
VAB027_3345	COG0191	fructose-bisphosphate aldolase activity
VAB027_3346	COG0126	phosphoglycerate kinase activity
VAB027_3347	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VAB027_3348	COG4771	TonB-dependent receptor
VAB027_3349	COG0583	DNA-binding transcription factor activity
VAB027_3350	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VAB027_3351	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VAB027_3352	COG3091	SprT-like family
VAB027_3353	COG2356	endonuclease I
VAB027_3354	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VAB027_3355	COG0189	ligase activity
VAB027_3356	COG1678	Uncharacterized ACR, COG1678
VAB027_3357	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VAB027_3358	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VAB027_3362	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VAB027_3363	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VAB027_3364	COG0762	integral membrane protein
VAB027_3365	COG1872	DUF167
VAB027_3367	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VAB027_3368	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VAB027_3369	COG2066	Belongs to the glutaminase family
VAB027_337	COG3275	phosphorelay sensor kinase activity
VAB027_3370	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VAB027_3371	COG1194	a g-specific adenine glycosylase
VAB027_3372	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VAB027_3373	COG0741	lytic transglycosylase activity
VAB027_338	COG3279	Response regulator of the LytR AlgR family
VAB027_3384	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VAB027_3385	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VAB027_3386	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VAB027_3387	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VAB027_3388	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VAB027_3389	COG2967	ApaG domain
VAB027_3390	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VAB027_3392	COG3610	response to peptide
VAB027_3393	COG2966	Psort location CytoplasmicMembrane, score
VAB027_3394	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VAB027_3395	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VAB027_3396	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VAB027_3397	COG0142	geranyltranstransferase activity
VAB027_3398	COG0531	amino acid
VAB027_3399	COG0039	L-malate dehydrogenase activity
VAB027_34	COG0242	peptide deformylase activity
VAB027_340	COG3706	GGDEF domain
VAB027_3400	COG1438	arginine binding
VAB027_3403	COG0589	response to stress
VAB027_3407	COG2235	arginine
VAB027_3408	COG0312	modulator of DNA gyrase
VAB027_3409	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VAB027_341	COG0531	amino acid
VAB027_3410	COG3164	Protein of unknown function
VAB027_3411	COG1530	ribonuclease E activity
VAB027_3412	COG0424	maF-like protein
VAB027_3413	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VAB027_3414	COG1792	Involved in formation and maintenance of cell shape
VAB027_3415	COG1077	Cell shape determining protein MreB Mrl
VAB027_342	COG1252	NADH dehydrogenase
VAB027_3426	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VAB027_3428	COG3267	Type II secretory pathway component ExeA
VAB027_3428	COG3409	Peptidoglycan-binding domain 1 protein
VAB027_3433	COG2200	EAL domain
VAB027_3433	COG2199	diguanylate cyclase activity
VAB027_3434	COG0629	single-stranded DNA binding
VAB027_3437	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VAB027_3439	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VAB027_3440	COG0527	aspartate kinase activity
VAB027_3441	COG1410	methionine synthase
VAB027_3441	COG0646	methionine synthase
VAB027_3449	COG0175	sulfate reduction
VAB027_3450	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VAB027_3451	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VAB027_3455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VAB027_3456	COG0735	belongs to the Fur family
VAB027_3459	COG0166	Belongs to the GPI family
VAB027_3460	COG0432	Pfam Uncharacterised protein family UPF0047
VAB027_3461	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VAB027_3462	COG0305	Participates in initiation and elongation during chromosome replication
VAB027_3464	COG0359	binds to the 23S rRNA
VAB027_3465	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
VAB027_3466	COG2965	DNA replication, synthesis of RNA primer
VAB027_3467	COG0360	Binds together with S18 to 16S ribosomal RNA
VAB027_3469	COG2906	2 iron, 2 sulfur cluster binding
VAB027_3470	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VAB027_3471	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VAB027_3472	COG0049	tRNA binding
VAB027_3473	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
VAB027_3475	COG2923	Belongs to the DsrF TusC family
VAB027_3476	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VAB027_3477	COG2964	Protein conserved in bacteria
VAB027_3478	COG0545	Peptidyl-prolyl cis-trans isomerase
VAB027_348	COG1765	OsmC-like protein
VAB027_3480	COG2900	Belongs to the SlyX family
VAB027_3481	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VAB027_3482	COG0330	HflC and HflK could
VAB027_3483	COG0330	HflC and HflK could
VAB027_3484	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VAB027_3485	COG1923	regulation of RNA biosynthetic process
VAB027_3486	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VAB027_3487	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VAB027_3489	COG0802	atpase or kinase
VAB027_349	COG1253	flavin adenine dinucleotide binding
VAB027_3490	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VAB027_35	COG1652	LysM domain
VAB027_350	COG2171	N-acyltransferase activity
VAB027_3500	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VAB027_3501	COG1162	GTPase activity
VAB027_3502	COG0688	phosphatidylethanolamine metabolic process
VAB027_3503	COG0471	metal ion transport
VAB027_3505	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VAB027_3507	COG4942	peptidase
VAB027_3509	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VAB027_3510	COG2816	NAD+ diphosphatase activity
VAB027_3511	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VAB027_3512	COG3385	transposase activity
VAB027_3513	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VAB027_3514	COG0085	RNA polymerase activity
VAB027_3515	COG0222	ribosome binding
VAB027_3516	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VAB027_3517	COG0081	regulation of translation
VAB027_3518	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VAB027_3519	COG0250	Participates in transcription elongation, termination and antitermination
VAB027_3520	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VAB027_3521	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VAB027_3526	COG1072	(Pantothenic acid kinase))
VAB027_3528	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VAB027_353	COG0583	DNA-binding transcription factor activity
VAB027_3530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAB027_3538	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VAB027_354	COG2264	protein methyltransferase activity
VAB027_3540	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
VAB027_3541	COG3118	belongs to the thioredoxin family
VAB027_3542	COG0513	Belongs to the DEAD box helicase family
VAB027_3543	COG0248	Ppx GppA phosphatase
VAB027_3544	COG2205	protein histidine kinase activity
VAB027_3544	COG0784	Response regulator, receiver
VAB027_3545	COG2814	Major facilitator Superfamily
VAB027_3548	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VAB027_3549	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VAB027_3550	COG0511	ligase activity, forming carbon-carbon bonds
VAB027_3551	COG0439	Biotin carboxylase
VAB027_3552	COG2264	protein methyltransferase activity
VAB027_3553	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VAB027_3554	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VAB027_3557	COG1609	Transcriptional regulator
VAB027_3558	COG0129	dihydroxy-acid dehydratase activity
VAB027_3559	COG3265	gluconokinase activity
VAB027_3561	COG0800	Aldolase
VAB027_3564	COG0840	transmembrane signaling receptor activity
VAB027_3565	COG1982	Orn Lys Arg decarboxylase major
VAB027_3566	COG0531	amino acid
VAB027_3567	COG3710	Transcriptional regulator
VAB027_3568	COG0789	Transcriptional regulator
VAB027_3569	COG0138	bifunctional purine biosynthesis protein purh
VAB027_357	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VAB027_3570	COG0151	Belongs to the GarS family
VAB027_3572	COG0776	regulation of translation
VAB027_3573	COG1253	flavin adenine dinucleotide binding
VAB027_358	COG3186	Phenylalanine-4-hydroxylase
VAB027_3580	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAB027_3581	COG3068	Protein conserved in bacteria
VAB027_3583	COG1573	uracil-dna glycosylase
VAB027_3584	COG0668	transmembrane transport
VAB027_3585	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VAB027_3587	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VAB027_359	COG2154	pterin-4-alpha-carbinolamine dehydratase
VAB027_3597	COG1028	Short-chain dehydrogenase reductase Sdr
VAB027_3598	COG1083	cytidylyl-transferase
VAB027_3599	COG0673	inositol 2-dehydrogenase activity
VAB027_36	COG0758	DNA mediated transformation
VAB027_360	COG0456	acetyltransferase
VAB027_3602	COG2089	acid synthase
VAB027_3603	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VAB027_3604	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VAB027_3606	COG5433	transposase activity
VAB027_3609	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
VAB027_361	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VAB027_3610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VAB027_3612	COG0110	maltose O-acetyltransferase activity
VAB027_3615	COG0859	PFAM glycosyl transferase family 9
VAB027_3617	COG1519	Transferase
VAB027_362	COG0662	Cupin 2, conserved barrel domain protein
VAB027_3623	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
VAB027_3623	COG2755	lipolytic protein G-D-S-L family
VAB027_3624	COG3642	lipopolysaccharide core region biosynthetic process
VAB027_3625	COG0859	PFAM glycosyl transferase family 9
VAB027_3626	COG0463	Glycosyl transferase, family 2
VAB027_3627	COG0859	PFAM glycosyl transferase family 9
VAB027_3628	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VAB027_3629	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VAB027_363	COG0527	aspartate kinase activity
VAB027_3631	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VAB027_3632	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VAB027_3635	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VAB027_3636	COG1309	transcriptional regulator
VAB027_3637	COG1560	Kdo2-lipid A biosynthetic process
VAB027_3638	COG1560	Kdo2-lipid A biosynthetic process
VAB027_3639	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VAB027_3640	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VAB027_3641	COG1561	YicC-like family, N-terminal region
VAB027_365	COG0459	protein refolding
VAB027_366	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VAB027_3664	COG1263	PTS System
VAB027_3664	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VAB027_3665	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VAB027_3669	COG1120	ATPase activity
VAB027_367	COG2239	Acts as a magnesium transporter
VAB027_3670	COG4774	siderophore transport
VAB027_3671	COG1132	(ABC) transporter
VAB027_3674	COG0514	ATP-dependent DNA helicase (RecQ)
VAB027_3675	COG2962	Rard protein
VAB027_3676	COG0405	Gamma-glutamyltransferase
VAB027_3678	COG1280	lysine exporter protein (LysE YggA)
VAB027_3679	COG0210	DNA helicase
VAB027_3681	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VAB027_3682	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VAB027_3684	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAB027_3686	COG0747	negative chemotaxis
VAB027_369	COG1166	arginine decarboxylase activity
VAB027_3695	COG1309	transcriptional regulator
VAB027_3696	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAB027_3697	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VAB027_3698	COG2960	long-chain fatty acid transporting porin activity
VAB027_3699	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VAB027_37	COG2922	Belongs to the Smg family
VAB027_3700	COG0583	DNA-binding transcription factor activity
VAB027_3709	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
VAB027_3710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VAB027_3711	COG1739	Uncharacterized protein family UPF0029
VAB027_3712	COG1024	Enoyl-CoA hydratase
VAB027_3712	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAB027_3713	COG0183	Belongs to the thiolase family
VAB027_3714	COG0583	DNA-binding transcription factor activity
VAB027_3715	COG2814	Major facilitator Superfamily
VAB027_3717	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VAB027_3718	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VAB027_3719	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VAB027_372	COG3227	Zinc metalloprotease (Elastase)
VAB027_3720	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VAB027_3721	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VAB027_3722	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VAB027_3724	COG0356	it plays a direct role in the translocation of protons across the membrane
VAB027_3725	COG3312	ion transport
VAB027_3726	COG1475	DNA binding
VAB027_3727	COG1192	Involved in chromosome partitioning
VAB027_3728	COG0357	Ribosomal RNA small subunit methyltransferase G
VAB027_3729	COG0445	tRNA wobble uridine modification
VAB027_373	COG3397	chitin binding
VAB027_3730	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VAB027_3733	COG0464	growth
VAB027_374	COG3046	protein related to deoxyribodipyrimidine photolyase
VAB027_3758	COG4974	Belongs to the 'phage' integrase family
VAB027_376	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VAB027_3760	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VAB027_3761	COG0706	membrane insertase activity
VAB027_3762	COG0594	ribonuclease P activity
VAB027_3763	COG1126	abc transporter atp-binding protein
VAB027_378	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
VAB027_379	COG0513	Belongs to the DEAD box helicase family
VAB027_38	COG0551	DNA topoisomerase type I activity
VAB027_381	COG1368	sulfuric ester hydrolase activity
VAB027_382	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VAB027_385	COG0546	phosphoglycolate phosphatase activity
VAB027_389	COG0484	heat shock protein binding
VAB027_39	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VAB027_393	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VAB027_395	COG4181	ATPase activity
VAB027_396	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
VAB027_399	COG1984	allophanate hydrolase subunit 2
VAB027_4	COG0187	DNA topoisomerase II activity
VAB027_40	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VAB027_401	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VAB027_402	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VAB027_404	COG0814	amino acid
VAB027_406	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
VAB027_407	COG0513	Belongs to the DEAD box helicase family
VAB027_408	COG1309	transcriptional regulator
VAB027_41	COG0009	L-threonylcarbamoyladenylate synthase
VAB027_412	COG0494	nUDIX hydrolase
VAB027_415	COG2425	protein containing a von Willebrand factor type A (vWA) domain
VAB027_417	COG1126	abc transporter atp-binding protein
VAB027_418	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAB027_419	COG4215	(ABC) transporter
VAB027_42	COG0408	coproporphyrinogen oxidase activity
VAB027_420	COG4160	amino acid transport
VAB027_421	COG0583	DNA-binding transcription factor activity
VAB027_427	COG3118	belongs to the thioredoxin family
VAB027_428	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VAB027_429	COG0247	lactate metabolic process
VAB027_43	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VAB027_430	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
VAB027_431	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VAB027_432	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VAB027_433	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VAB027_439	COG2827	Endonuclease containing a URI domain
VAB027_44	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VAB027_441	COG1879	ABC-type sugar transport system periplasmic component
VAB027_443	COG5002	protein histidine kinase activity
VAB027_443	COG0784	Response regulator, receiver
VAB027_449	COG1618	nucleotide phosphatase activity, acting on free nucleotides
VAB027_450	COG3385	transposase activity
VAB027_453	COG1492	cobalamin metabolic process
VAB027_454	COG0725	ABC transporter, periplasmic molybdate-binding protein
VAB027_455	COG4149	molybdate abc transporter
VAB027_456	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
VAB027_462	COG1289	transmembrane transporter activity
VAB027_463	COG0210	DNA helicase
VAB027_464	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VAB027_465	COG1335	isochorismatase
VAB027_466	COG1803	Methylglyoxal synthase
VAB027_467	COG1879	ABC-type sugar transport system periplasmic component
VAB027_468	COG2205	protein histidine kinase activity
VAB027_468	COG0784	Response regulator, receiver
VAB027_468	COG2198	Histidine kinase
VAB027_469	COG0469	pyruvate kinase activity
VAB027_470	COG2271	Major facilitator Superfamily
VAB027_471	COG1840	ABC-type Fe3 transport system, periplasmic component
VAB027_472	COG4191	Histidine kinase
VAB027_475	COG1979	alcohol dehydrogenase
VAB027_477	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VAB027_478	COG3706	GGDEF domain
VAB027_481	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VAB027_482	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VAB027_484	COG0183	Belongs to the thiolase family
VAB027_486	COG3243	poly(R)-hydroxyalkanoic acid synthase
VAB027_487	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VAB027_491	COG0243	molybdopterin cofactor binding
VAB027_493	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VAB027_494	COG3850	Histidine kinase
VAB027_495	COG2197	response regulator
VAB027_496	COG1609	Transcriptional regulator
VAB027_503	COG3069	C4-dicarboxylate transmembrane transporter activity
VAB027_504	COG0840	transmembrane signaling receptor activity
VAB027_505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VAB027_506	COG0545	Peptidyl-prolyl cis-trans isomerase
VAB027_507	COG2885	chlorophyll binding
VAB027_509	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VAB027_510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VAB027_511	COG1621	beta-fructofuranosidase activity
VAB027_513	COG1263	PTS System
VAB027_513	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VAB027_52	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VAB027_522	COG0446	pyridine nucleotide-disulphide oxidoreductase
VAB027_524	COG0640	Transcriptional regulator
VAB027_529	COG0778	Nitroreductase
VAB027_53	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VAB027_530	COG0583	DNA-binding transcription factor activity
VAB027_531	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
VAB027_536	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAB027_538	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VAB027_543	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VAB027_544	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VAB027_545	COG2390	Transcriptional regulator
VAB027_546	COG2897	thiosulfate sulfurtransferase activity
VAB027_548	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VAB027_55	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VAB027_550	COG0302	gtp cyclohydrolase
VAB027_551	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAB027_551	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAB027_552	COG2759	Belongs to the formate--tetrahydrofolate ligase family
VAB027_553	COG1970	mechanosensitive ion channel activity
VAB027_554	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
VAB027_556	COG1011	Hydrolase
VAB027_557	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VAB027_558	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VAB027_56	COG2104	thiamine diphosphate biosynthetic process
VAB027_560	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VAB027_561	COG1840	ABC-type Fe3 transport system, periplasmic component
VAB027_563	COG3842	ATPase activity
VAB027_57	COG2022	thiamine diphosphate biosynthetic process
VAB027_572	COG4166	transmembrane transport
VAB027_573	COG4174	ABC transporter (Permease)
VAB027_574	COG4239	(ABC) transporter, permease
VAB027_575	COG4172	Belongs to the ABC transporter superfamily
VAB027_576	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VAB027_579	COG0625	glutathione transferase activity
VAB027_58	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VAB027_583	COG2050	protein possibly involved in aromatic compounds catabolism
VAB027_586	COG4771	TonB-dependent receptor
VAB027_587	COG0583	DNA-binding transcription factor activity
VAB027_588	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VAB027_588	COG0045	succinate-CoA ligase (ADP-forming) activity
VAB027_588	COG1042	CoA-binding domain protein
VAB027_59	COG0006	proline dipeptidase activity
VAB027_59	COG0006	proline dipeptidase activity
VAB027_590	COG1181	Belongs to the D-alanine--D-alanine ligase family
VAB027_592	COG0023	Translation Initiation Factor
VAB027_593	COG1943	Transposase
VAB027_599	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VAB027_600	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VAB027_604	COG3706	GGDEF domain
VAB027_613	COG2824	Alkylphosphonate utilization operon protein PhnA
VAB027_616	COG0737	Belongs to the 5'-nucleotidase family
VAB027_617	COG3593	DNA synthesis involved in DNA repair
VAB027_619	COG0583	DNA-binding transcription factor activity
VAB027_620	COG2116	formate transmembrane transporter activity
VAB027_622	COG3038	cytochrome b561
VAB027_624	COG2200	EAL domain
VAB027_626	COG0586	Pfam SNARE associated Golgi protein
VAB027_627	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VAB027_628	COG0745	RESPONSE REGULATOR receiver
VAB027_629	COG2205	protein histidine kinase activity
VAB027_63	COG1522	sequence-specific DNA binding
VAB027_630	COG0674	pyruvate-flavodoxin oxidoreductase activity
VAB027_630	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
VAB027_630	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VAB027_630	COG1013	pyruvate-flavodoxin oxidoreductase activity
VAB027_631	COG3158	transport of potassium into the cell
VAB027_633	COG0523	cobalamin synthesis protein
VAB027_634	COG0038	chloride channel
VAB027_636	COG0156	8-amino-7-oxononanoate synthase activity
VAB027_637	COG2205	protein histidine kinase activity
VAB027_637	COG0784	Response regulator, receiver
VAB027_638	COG0419	ATPase involved in DNA repair
VAB027_639	COG0420	3'-5' exonuclease activity
VAB027_64	COG5001	Diguanylate cyclase
VAB027_64	COG5002	protein histidine kinase activity
VAB027_640	COG1609	Transcriptional regulator
VAB027_641	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAB027_641	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAB027_642	COG1105	Belongs to the carbohydrate kinase PfkB family
VAB027_643	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VAB027_643	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
VAB027_643	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VAB027_644	COG0189	ligase activity
VAB027_644	COG4067	protein conserved in archaea
VAB027_646	COG0602	queuosine metabolic process
VAB027_647	COG1328	CTP reductase activity
VAB027_65	COG0742	ribosomal rna small subunit methyltransferase
VAB027_658	COG1619	proteins homologs of microcin C7 resistance protein MccF
VAB027_67	COG0697	spore germination
VAB027_670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VAB027_674	COG4115	mRNA cleavage
VAB027_675	COG2161	toxin-antitoxin pair type II binding
VAB027_678	COG0346	lactoylglutathione lyase activity
VAB027_68	COG0589	response to stress
VAB027_69	COG1528	Iron-storage protein
VAB027_696	COG0494	nUDIX hydrolase
VAB027_7	COG0071	Belongs to the small heat shock protein (HSP20) family
VAB027_705	COG0346	lactoylglutathione lyase activity
VAB027_717	COG0456	acetyltransferase
VAB027_72	COG2081	HI0933 family
VAB027_720	COG2944	sequence-specific DNA binding
VAB027_721	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
VAB027_723	COG1619	proteins homologs of microcin C7 resistance protein MccF
VAB027_727	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
VAB027_73	COG1322	Protein conserved in bacteria
VAB027_732	COG3041	Addiction module toxin RelE StbE family
VAB027_735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VAB027_739	COG3093	addiction module antidote protein HigA
VAB027_74	COG2226	methyltransferase
VAB027_740	COG3549	Plasmid maintenance system killer
VAB027_755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VAB027_759	COG0346	lactoylglutathione lyase activity
VAB027_76	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VAB027_769	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
VAB027_77	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VAB027_770	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VAB027_772	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VAB027_773	COG0404	The glycine cleavage system catalyzes the degradation of glycine
VAB027_775	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VAB027_776	COG0509	glycine decarboxylation via glycine cleavage system
VAB027_777	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VAB027_777	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VAB027_779	COG3338	carbonate dehydratase activity
VAB027_78	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VAB027_782	COG1686	Belongs to the peptidase S11 family
VAB027_786	COG0583	DNA-binding transcription factor activity
VAB027_789	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VAB027_79	COG0805	protein transport
VAB027_794	COG5002	protein histidine kinase activity
VAB027_794	COG5000	phosphorelay sensor kinase activity
VAB027_795	COG0745	RESPONSE REGULATOR receiver
VAB027_8	COG3977	Valine--pyruvate aminotransferase
VAB027_80	COG1858	cytochrome C peroxidase
VAB027_804	COG0561	phosphatase activity
VAB027_805	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
VAB027_806	COG3623	hexulose-6-phosphate isomerase
VAB027_808	COG0745	RESPONSE REGULATOR receiver
VAB027_81	COG0534	Mate efflux family protein
VAB027_812	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VAB027_816	COG4604	ABC transporter, ATP-binding protein
VAB027_817	COG4605	iron ion homeostasis
VAB027_818	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VAB027_822	COG3291	Pkd domain containing protein
VAB027_822	COG4412	M6 family metalloprotease domain protein
VAB027_823	COG5380	lipid catabolic process
VAB027_824	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
VAB027_825	COG0840	transmembrane signaling receptor activity
VAB027_828	COG3240	lipase activity
VAB027_83	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VAB027_830	COG3706	GGDEF domain
VAB027_831	COG2814	Major facilitator Superfamily
VAB027_832	COG1757	Na H antiporter
VAB027_834	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAB027_834	COG4191	Histidine kinase
VAB027_835	COG3437	response regulator, receiver
VAB027_835	COG0784	Response regulator, receiver
VAB027_836	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VAB027_838	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VAB027_839	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VAB027_84	COG2937	Belongs to the GPAT DAPAT family
VAB027_840	COG0513	Belongs to the DEAD box helicase family
VAB027_841	COG1204	response to ionizing radiation
VAB027_843	COG0516	GMP reductase activity
VAB027_845	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VAB027_847	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
VAB027_847	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
VAB027_848	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VAB027_85	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VAB027_853	COG3036	rescue of stalled ribosome
VAB027_854	COG1278	Cold shock
VAB027_855	COG1017	nitric oxide dioxygenase activity
VAB027_855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VAB027_857	COG3604	Transcriptional regulator
VAB027_858	COG2195	Cleaves the N-terminal amino acid of tripeptides
VAB027_859	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VAB027_86	COG3161	chorismate lyase activity
VAB027_862	COG0840	transmembrane signaling receptor activity
VAB027_863	COG0714	Associated with various cellular activities
VAB027_867	COG2304	oxidoreductase activity
VAB027_87	COG1580	Controls the rotational direction of flagella during chemotaxis
VAB027_870	COG1278	Cold shock
VAB027_871	COG5002	protein histidine kinase activity
VAB027_871	COG5001	Diguanylate cyclase
VAB027_873	COG3530	Putative quorum-sensing-regulated virulence factor
VAB027_874	COG3033	Beta-eliminating lyase
VAB027_875	COG0814	amino acid
VAB027_876	COG0589	response to stress
VAB027_878	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VAB027_878	COG2111	Na H antiporter
VAB027_88	COG0840	transmembrane signaling receptor activity
VAB027_882	COG2212	antiporter activity
VAB027_883	COG1320	monovalent cation:proton antiporter activity
VAB027_884	COG1017	nitric oxide dioxygenase activity
VAB027_884	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VAB027_885	COG0242	peptide deformylase activity
VAB027_887	COG0579	oxidoreductase
VAB027_894	COG2271	Major facilitator Superfamily
VAB027_895	COG0584	glycerophosphoryl diester phosphodiesterase
VAB027_897	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VAB027_899	COG1609	Transcriptional regulator
VAB027_9	COG0751	glycine-tRNA ligase activity
VAB027_90	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VAB027_900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VAB027_901	COG1879	ABC-type sugar transport system periplasmic component
VAB027_902	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAB027_903	COG1129	ABC transporter
VAB027_904	COG1869	D-ribose catabolic process
VAB027_907	COG3501	Rhs element vgr protein
VAB027_91	COG0084	hydrolase, TatD family'
VAB027_925	COG0564	pseudouridine synthase activity
VAB027_927	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VAB027_928	COG2771	luxR family
VAB027_928	COG2200	EAL domain
VAB027_930	COG0673	inositol 2-dehydrogenase activity
VAB027_931	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
VAB027_936	COG1342	Belongs to the UPF0251 family
VAB027_938	COG1301	dicarboxylic acid transport
VAB027_94	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VAB027_94	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VAB027_943	COG2814	Major facilitator Superfamily
VAB027_944	COG0583	DNA-binding transcription factor activity
VAB027_946	COG5001	Diguanylate cyclase
VAB027_946	COG3300	MHYT domain
VAB027_947	COG0739	heme binding
VAB027_949	COG0659	secondary active sulfate transmembrane transporter activity
VAB027_95	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VAB027_953	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VAB027_954	COG0581	inorganic phosphate transmembrane transporter activity
VAB027_955	COG0573	inorganic phosphate transmembrane transporter activity
VAB027_956	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VAB027_962	COG1770	oligopeptidase
VAB027_963	COG0513	Belongs to the DEAD box helicase family
VAB027_966	COG1376	ErfK ybiS ycfS ynhG family protein
VAB027_966	COG1388	LysM domain
VAB027_967	COG0415	Belongs to the DNA photolyase family
VAB027_969	COG3272	Protein of unknown function (DUF1722)
VAB027_970	COG0813	purine-nucleoside phosphorylase activity
VAB027_973	COG3706	GGDEF domain
VAB027_977	COG0786	glutamate:sodium symporter activity
VAB027_98	COG3078	GTPase activator activity
VAB027_980	COG1999	signal sequence binding
VAB027_982	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
VAB027_984	COG0671	phosphoesterase, PA-phosphatase related
VAB027_995	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)