locus-tag class description VAA049_1 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) VAA049_10 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit VAA049_100 ENOG4105D4P Coproporphyrinogen iii oxidase VAA049_1000 ENOG4105CYN Serine protein kinase VAA049_1001 ENOG4105XWI UPF0304 protein VAA049_1003 ENOG4105F1A Pyruvate formate-lyase VAA049_1004 ENOG4108N3W hemolysin secretion protein VAA049_1006 ENOG4105C6N Formate acetyltransferase VAA049_1009 ENOG4108JEH abc transporter atp-binding protein VAA049_101 ENOG410601J HemY protein VAA049_1010 ENOG4105E89 ABC transporter VAA049_1011 ENOG4105DSP amino acid AbC transporter VAA049_1012 ENOG4106YG3 ABC transporter VAA049_1013 ENOG4105CGK Exodeoxyribonuclease III VAA049_1014 ENOG4105C8Q Methyl-accepting chemotaxis VAA049_1015 ENOG4106428 Protein of unknown function (DUF2496) VAA049_1016 ENOG4108URS primosomal replication protein n'' VAA049_1017 ENOG4105EJ9 Membrane VAA049_1018 ENOG4105DVT helicase VAA049_1019 ENOG4105ZU8 porin-like protein H VAA049_102 ENOG4105ECF c-methyltransferase VAA049_1021 ENOG4108J1Q VAA049_1023 ENOG4105D58 Diguanylate phosphodiesterase VAA049_1024 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) VAA049_1025 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) VAA049_1026 ENOG4105C8N cysteinyl-tRNA synthetase VAA049_1027 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) VAA049_1028 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) VAA049_1029 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) VAA049_103 ENOG41076E6 Uroporphyrinogen-III Synthase VAA049_1030 ENOG4105C4M (Ubiquinol oxidase) subunit I VAA049_1031 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii VAA049_1033 ENOG4107YD3 Thioesterase VAA049_1034 ENOG4105E02 MotA TolQ exbB proton channel VAA049_1035 ENOG4105M8F Biopolymer transport protein exbD tolR VAA049_1037 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) VAA049_1038 ENOG4105KCK Peptidoglycan-associated lipoprotein VAA049_104 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) VAA049_1040 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) VAA049_1042 ENOG4105BZU Histidine kinase VAA049_1043 ENOG4108RNS Exports L-alanine (By similarity) VAA049_1044 ENOG4105EIP mannose-6-phosphate isomerase VAA049_1045 ENOG4105DM4 PTS System VAA049_1047 ENOG4106R3P AraC family transcriptional regulator VAA049_1048 ENOG4108YRF PTS System VAA049_1049 ENOG4105DM4 PTS System VAA049_105 ENOG4107T0K Adenylate cyclase VAA049_1050 ENOG4105DM4 PTS System VAA049_1051 ENOG4105DM4 PTS System VAA049_1052 ENOG4105C26 Dehydrogenase VAA049_1053 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family VAA049_1054 ENOG4105VYA Uncharacterized conserved protein (DUF2132) VAA049_1056 ENOG4105CVP deoxyribo-dipyrimidine photolyase VAA049_106 ENOG4105XQ6 frataxin-like protein VAA049_1064 ENOG4105DY2 Paraquat-inducible protein b VAA049_1065 ENOG4105F1S paraquat-inducible protein a VAA049_1066 ENOG4108R86 Transcriptional regulator VAA049_1067 ENOG4105MTM Protein of unknown function (DUF1496) VAA049_1068 ENOG4105C26 Dehydrogenase VAA049_107 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) VAA049_1070 ENOG41067SE Tetr family transcriptional regulator VAA049_1071 ENOG4107QPN acyl-Coa dehydrogenase VAA049_1073 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) VAA049_1074 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate VAA049_1075 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) VAA049_1076 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase VAA049_1077 ENOG4105RKX Protein of unknown function (DUF2498) VAA049_1078 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) VAA049_1079 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) VAA049_108 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) VAA049_1080 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) VAA049_1084 ENOG4105HP8 regulator of competence-specific genes VAA049_1085 ENOG4105ETE Transcriptional regulator (LacI family VAA049_1087 ENOG4106WF9 DNA-binding transcriptional regulator TorR VAA049_1088 ENOG4107S90 membrAne VAA049_1089 ENOG4106371 Methyltransferase VAA049_109 ENOG4105CT0 Protein of unknown function, DUF484 VAA049_1090 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) VAA049_1091 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) VAA049_1092 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) VAA049_1093 ENOG4105EW9 transcriptional regulator AsnC family VAA049_1095 ENOG4105CCT upf0313 protein VAA049_110 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) VAA049_1100 ENOG4105DZ2 Transcriptional regulator VAA049_1101 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) VAA049_1103 ENOG4105K9H YciI-like protein VAA049_1104 ENOG4105NAU thioesterase Superfamily protein VAA049_1105 ENOG4107835 probably involved in intracellular septation (By similarity) VAA049_1107 ENOG4105GFG DUF218 domain VAA049_1108 ENOG4108535 NAD dependent epimerase/dehydratase family VAA049_111 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant VAA049_1110 ENOG4105TMB Formate nitrite transporter VAA049_1113 ENOG4107QY8 reductase VAA049_1116 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase VAA049_1119 ENOG4108JQ2 peptide transport system atp-binding protein VAA049_112 ENOG4105BZU Histidine kinase VAA049_1120 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein VAA049_1121 ENOG4108EU3 peptide transport system, permease VAA049_1122 ENOG4108I5W peptide transport system, permease protein VAA049_1123 ENOG4108J59 Extracellular solute-binding protein, family 5 VAA049_1124 ENOG4105E51 psp operon transcriptional activator VAA049_1125 ENOG41087YS Phage shock protein A VAA049_1128 ENOG4105C1P efflux transporter, rnd family, mfp subunit VAA049_1131 ENOG4108R3E Dna-3-methyladenine glycosylase i VAA049_1132 ENOG4105C28 cystathionine VAA049_1134 ENOG4105C8J )-transporter VAA049_1135 ENOG4108W1A pseudouridine synthase VAA049_1136 ENOG4108T9J Cdp-alcohol phosphatidyltransferase VAA049_1137 ENOG4108VGW abc transporter atp-binding protein VAA049_1138 ENOG4105CXZ ABC transporter, permease VAA049_1139 ENOG4105VNH ABC transporter solute-binding protein VAA049_1141 ENOG4105XZD Fe-S protein VAA049_1143 ENOG4107QWP ABC-2 type transporter VAA049_1144 ENOG4105CJ1 ABC, transporter VAA049_1146 ENOG4105C44 Serine transporter VAA049_1149 ENOG4105CJW magnesium transporter VAA049_115 ENOG4105DQF Hydrolase VAA049_1150 ENOG4105BZU Histidine kinase VAA049_1151 ENOG4105BZU Histidine kinase VAA049_1153 ENOG4105KXC Collagenase VAA049_116 ENOG4108EUD Lysophospholipase VAA049_1161 ENOG4108N3W hemolysin secretion protein VAA049_1164 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) VAA049_1165 ENOG4105BZU Histidine kinase VAA049_1168 ENOG4105CFI type iii restriction protein res subunit VAA049_1169 ENOG4105I08 Pseudouridine synthase VAA049_117 ENOG410829K Lysine exporter protein (Lyse ygga) VAA049_1170 ENOG4105C2C drug resistance transporter, Bcr CflA VAA049_1172 ENOG4105CGD Nad-dependent epimerase dehydratase VAA049_1173 ENOG4105UQX Mate efflux family protein VAA049_1174 ENOG4108I0Y (ABC) transporter VAA049_1177 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) VAA049_1179 ENOG4105E3Q saccharopine dehydrogenase VAA049_118 ENOG4105D58 Diguanylate phosphodiesterase VAA049_1180 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) VAA049_1181 ENOG4105CDV Ompa motb domain protein VAA049_1182 ENOG4105DFG type I secretion outer membrane protein VAA049_1187 ENOG4105F04 LysR family Transcriptional regulator VAA049_1189 ENOG4108VKG metal-dependent hydrolase VAA049_119 ENOG4108RMU ferritin dps family protein VAA049_1190 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) VAA049_1192 ENOG41090FY type IV pilus biogenesis stability protein PilW VAA049_1193 ENOG4105CVG Homoserine O-transsuccinylase VAA049_1197 ENOG4107V40 secretion protein, HlyD family VAA049_1200 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism VAA049_1201 ENOG4106YYS transcriptional regulatory protein VAA049_1203 ENOG4107R88 Chemotaxis protein (CheV) VAA049_1206 ENOG4105BZU Histidine kinase VAA049_1211 ENOG4105F0Z galactose-1-phosphate uridylyltransferase VAA049_1212 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) VAA049_1213 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) VAA049_1214 ENOG4106TD9 Diguanylate cyclase VAA049_1215 ENOG4105BZU Histidine kinase VAA049_1217 ENOG4105C7K acetolactate synthase VAA049_1218 ENOG4107FQX Alpha-acetolactate decarboxylase VAA049_1221 ENOG4108TWJ NADH dehydrogenase subunit 5 VAA049_1222 ENOG4105DUM transcriptional regulator, lysR family VAA049_1223 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) VAA049_1226 ENOG4105V0I UPF0267 protein VAA049_1229 ENOG4105C9Q fumarate hydratase class II VAA049_1231 ENOG4105C4M (Ubiquinol oxidase) subunit I VAA049_1232 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii VAA049_1233 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) VAA049_1234 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) VAA049_1237 ENOG4107QZV Type I secretion membrane fusion protein VAA049_124 ENOG4106H78 methyltransferase VAA049_1240 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) VAA049_1241 ENOG4105CS2 ec 3.2.1.21 VAA049_1242 ENOG4105DDV Transcriptional regulator (LacI family VAA049_1243 ENOG4105M4H endoribonuclease L-psp VAA049_1244 ENOG4105XEP YhcH YjgK YiaL family protein VAA049_1245 ENOG4107VXM glycerophosphoryl diester phosphodiesterase VAA049_1246 ENOG4105E98 transcriptional regulator DeoR family VAA049_1247 ENOG4108IJ9 (ABC) transporter VAA049_1248 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component VAA049_125 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) VAA049_1254 ENOG4109015 Biopolymer transport protein exbD tolR VAA049_1255 ENOG41067XB TonB family VAA049_1259 ENOG4107QI1 Mate efflux family protein VAA049_126 ENOG4105CAK Cell division ATP-binding protein ftsE VAA049_1261 ENOG4105FGM Fructosamine kinase VAA049_1263 ENOG4107TT5 NLP P60 protein VAA049_1264 ENOG4105C8Q Methyl-accepting chemotaxis VAA049_1266 ENOG4106IUH DTW domain containing protein VAA049_1267 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) VAA049_127 ENOG4105CRP Part of the ABC transporter FtsEX involved in VAA049_1270 ENOG4105CVM Molybdenum cofactor synthesis domain protein VAA049_1271 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) VAA049_1272 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) VAA049_1273 ENOG4107A5B Binding-protein-dependent transport systems, inner membrane component VAA049_1275 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VAA049_1276 ENOG4105BZU Histidine kinase VAA049_1277 ENOG4105C5H ABC transporter VAA049_1278 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) VAA049_128 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VAA049_1282 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) VAA049_1284 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) VAA049_1285 ENOG4105QAX Iron-sulfur VAA049_1288 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) VAA049_129 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) VAA049_1290 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) VAA049_1293 ENOG4105QNR S1 RNA binding domain protein VAA049_1294 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B VAA049_1295 ENOG4105DY2 Paraquat-inducible protein b VAA049_1296 ENOG4105H2K paraquat-inducible protein a VAA049_1297 ENOG4105BZ1 (ABC) transporter VAA049_1298 ENOG4108ZGC gaf domain protein VAA049_1299 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) VAA049_13 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) VAA049_1300 ENOG4105CN1 protease VAA049_1302 ENOG4105CD8 aminopeptidase N VAA049_1303 ENOG4105C7I Dehydrogenase VAA049_1304 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) VAA049_1305 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) VAA049_1306 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) VAA049_1308 ENOG4105C5H ABC transporter VAA049_1311 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) VAA049_1312 ENOG4105DAN ATP-dependent protease VAA049_1313 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) VAA049_132 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) VAA049_133 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) VAA049_134 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin VAA049_1356 ENOG4105EUK rtx toxin RtxA VAA049_1357 ENOG4108RC6 RTX toxin VAA049_136 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) VAA049_1362 ENOG4105BZU Histidine kinase VAA049_1365 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i VAA049_1368 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) VAA049_1370 ENOG4105C59 p-type ATPase VAA049_1373 ENOG4105DS0 Transcriptional regulator, Crp Fnr family VAA049_1374 ENOG4105Q9Y Universal stress protein VAA049_1375 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) VAA049_1379 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) VAA049_1380 ENOG4105F38 ABC transporter, permease VAA049_1381 ENOG4105D38 putrescine abc transporter VAA049_1382 ENOG4107RUE extracellular solute-binding protein family 1 VAA049_1383 ENOG4107RUE extracellular solute-binding protein family 1 VAA049_1386 ENOG4105BZG amino acid carrier protein VAA049_1387 ENOG410829K Lysine exporter protein (Lyse ygga) VAA049_1391 ENOG4105CS6 Rhs element vgr protein VAA049_1392 ENOG4108WC9 type VI secretion system effector, hcp1 family VAA049_1393 ENOG4105CTD carboxy-peptidase VAA049_1394 ENOG4105C8Q Methyl-accepting chemotaxis VAA049_1395 ENOG4105C0R drug resistance transporter emrb qaca subfamily VAA049_1396 ENOG4105CW7 secretion protein, HlyD family VAA049_1397 ENOG4105ENJ RND efflux system, outer membrane lipoprotein VAA049_1399 ENOG4105C1J atp-dependent rna helicase VAA049_1400 ENOG4107SDU Methyl-accepting chemotaxis VAA049_1401 ENOG4108N3W hemolysin secretion protein VAA049_1402 ENOG4105C8Q Methyl-accepting chemotaxis VAA049_1403 ENOG4108V3W Chemotaxis protein, CheW VAA049_1404 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) VAA049_1406 ENOG4105BZU Histidine kinase VAA049_1407 ENOG4105CBS Chea signal transduction histidine kinase VAA049_1408 ENOG4105CBS Chea signal transduction histidine kinase VAA049_1410 ENOG4108VYJ response regulator receiver protein VAA049_1411 ENOG4108NVR Methyl-accepting chemotaxis VAA049_1412 ENOG4105KPY Small multidrug resistance protein VAA049_1413 ENOG4105CVP deoxyribo-dipyrimidine photolyase VAA049_1414 ENOG4105C0R drug resistance transporter emrb qaca subfamily VAA049_1415 ENOG4105EJC lysr family transcriptional regulator VAA049_1416 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) VAA049_1417 ENOG4105R8A Heat shock protein VAA049_1419 ENOG4105CQ7 ATP-dependent helicase VAA049_1424 ENOG4105BZU Histidine kinase VAA049_1426 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB VAA049_1427 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB VAA049_1428 ENOG4105BZU Histidine kinase VAA049_1430 ENOG4105BZU Histidine kinase VAA049_1433 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) VAA049_1435 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) VAA049_1437 ENOG410667J hydrolase VAA049_1439 ENOG4107QXX ABC transporter VAA049_1440 ENOG4105EZ7 amino acid ABC transporter VAA049_1441 ENOG4105DRP amino acid AbC transporter VAA049_1442 ENOG4105CDA abc transporter atp-binding protein VAA049_1443 ENOG4108MN8 Membrane VAA049_1444 ENOG4108Z0T Part of a sulfur-relay system (By similarity) VAA049_1445 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 VAA049_1446 ENOG4105DR4 Methyltransferase VAA049_1447 ENOG4106TD9 Diguanylate cyclase VAA049_1449 ENOG4105BZU Histidine kinase VAA049_1450 ENOG4108RXX maleylacetoacetate isomerase VAA049_1451 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase VAA049_1453 ENOG4105F1J Homogentisate 1,2-dioxygenase VAA049_1454 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase VAA049_1455 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) VAA049_1458 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) VAA049_1459 ENOG4105C7F AcnD-accessory protein PrpF VAA049_1460 ENOG4108I0Z Aconitate hydratase VAA049_1461 ENOG4105BZN citrate synthase VAA049_1462 ENOG4105CR4 methylisocitrate lyase VAA049_1463 ENOG41073TP transcriptional regulator VAA049_1469 ENOG4107SDZ Galactoside transport system permease protein mglC VAA049_1470 ENOG4105C2J ABC transporter VAA049_1475 ENOG4107EXC regulatoR VAA049_1476 ENOG4105GR3 Histidine kinase VAA049_1477 ENOG4105RW8 MltA-interacting MipA family protein VAA049_1478 ENOG4108MJ5 VirK protein VAA049_1479 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VAA049_1480 ENOG4105BZU Histidine kinase VAA049_1481 ENOG4105C8P )-transporter VAA049_1482 ENOG4108NVR Methyl-accepting chemotaxis VAA049_1483 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) VAA049_1486 ENOG4105D9U N-acetyltransferase VAA049_1487 ENOG4108JU8 Transcriptional regulator VAA049_1489 ENOG4105CM6 amino acid regulated cytosolic protein VAA049_149 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) VAA049_1492 ENOG4105CRQ synthase (Component I) VAA049_1493 ENOG4105P8F nudix hydrolase VAA049_1494 ENOG4105C44 Serine transporter VAA049_1495 ENOG4105EJQ L-serine dehydratase VAA049_1496 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase VAA049_1497 ENOG4108N3W hemolysin secretion protein VAA049_1498 ENOG4105C5S asparaginyl-tRNA synthetase VAA049_15 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family VAA049_150 ENOG4105BZU Histidine kinase VAA049_1500 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase VAA049_1501 ENOG4105CGF Aromatic amino acid aminotransferase VAA049_1504 ENOG4105C8Q Methyl-accepting chemotaxis VAA049_1505 ENOG4105DJ9 glucan biosynthesis protein VAA049_1506 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) VAA049_1507 ENOG41060NJ transcriptional regulator VAA049_1508 ENOG410901P UPF0249 protein VAA049_1509 ENOG4105F8D glycoside hydrolase family 4 VAA049_151 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VAA049_1510 ENOG4105VCP PTS System VAA049_1512 ENOG4105VZJ PTS System VAA049_1514 ENOG4105C94 Transporter VAA049_1515 ENOG41067TZ transcriptional regulator, MarR family VAA049_1518 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VAA049_152 ENOG4105CUX Signal transduction histidine kinase VAA049_1520 ENOG4105CH5 extracellular solute-binding protein, family 7 VAA049_1522 ENOG4105C5X domain protein VAA049_1524 ENOG4105EAQ (twin-arginine translocation) pathway signal VAA049_1530 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) VAA049_1532 ENOG4105S8Q sugar efflux transporter VAA049_1534 ENOG4105C72 UPF0176 protein VAA049_1535 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) VAA049_1536 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) VAA049_1537 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) VAA049_1538 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) VAA049_1539 ENOG4107QK7 reductase VAA049_154 ENOG4105C5F glutamine synthetase VAA049_1544 ENOG4105C8Q Methyl-accepting chemotaxis VAA049_1546 ENOG4108J1Q VAA049_1548 ENOG4105EST Metal Dependent Phosphohydrolase VAA049_1572 ENOG4105KRQ Addiction module toxin, Txe YoeB family VAA049_1586 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase VAA049_159 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) VAA049_1591 ENOG4105BZU Histidine kinase VAA049_1595 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) VAA049_1596 ENOG41082NX 50s ribosomal protein l35 VAA049_1597 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) VAA049_1598 ENOG4105C22 threonyL-tRNA synthetase VAA049_16 ENOG4105C7B Threonine dehydratase VAA049_160 ENOG4105SUU thioesterase domain VAA049_162 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase VAA049_1627 ENOG4105KUS lysozyme VAA049_163 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) VAA049_1631 ENOG4106050 phage regulatory protein, rha family VAA049_1639 ENOG4108XTP Transcriptional regulator VAA049_164 ENOG4105VEJ Heat shock protein VAA049_1648 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) VAA049_165 ENOG4108XKW General secretion pathway protein C VAA049_1650 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) VAA049_1651 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) VAA049_1652 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor VAA049_1653 ENOG4108UHE carbonic anhydrase VAA049_1656 ENOG4105DZ1 carboxypeptidase VAA049_1658 ENOG4105C8Q Methyl-accepting chemotaxis VAA049_1660 ENOG4107QVI Methyltransferase, type 11 VAA049_1665 ENOG4105BZU Histidine kinase VAA049_1666 ENOG4105XJC Two component transcriptional regulator (Winged helix family VAA049_167 ENOG4107QHF type ii secretion system protein e VAA049_1678 ENOG410667J hydrolase VAA049_168 ENOG4105D7Q type ii secretion system VAA049_1680 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase VAA049_1682 ENOG4105ETX regulatoR VAA049_1686 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) VAA049_169 ENOG4108VAU general secretion pathway protein G VAA049_1690 ENOG4108IPW abc transporter atp-binding protein VAA049_1691 ENOG4105CM4 permease protein VAA049_1692 ENOG4105DHS permease protein VAA049_1698 ENOG4107G87 m6 family metalloprotease domain protein VAA049_17 ENOG4105C01 Dihydroxy-acid dehydratase VAA049_170 ENOG4105VWV general secretion pathway protein h VAA049_1700 ENOG4107IFA Lipase (EC 3.1.1.3) VAA049_1701 ENOG4108N3W hemolysin secretion protein VAA049_1702 ENOG4106M3D hemolysin VAA049_1703 ENOG4105KUU lipolytic protein G-D-S-L family VAA049_1705 ENOG4105BZU Histidine kinase VAA049_1706 ENOG4105E5M Multidrug resistance protein D VAA049_1707 ENOG4107S6Z Na H antiporter VAA049_1709 ENOG4105BZU Histidine kinase VAA049_171 ENOG4105X5Z General secretion pathway protein I VAA049_1710 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase VAA049_1711 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) VAA049_1712 ENOG4107RA1 nh(3)-dependent nad( ) synthetase VAA049_1713 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter VAA049_1714 ENOG4105C1J atp-dependent rna helicase VAA049_172 ENOG4108WWZ General secretion pathway protein J VAA049_1721 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) VAA049_1725 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) VAA049_1726 ENOG4105C5I Dehydrogenase VAA049_1728 ENOG4108UNF response regulator VAA049_173 ENOG4108RTD type II secretion system protein K VAA049_1732 ENOG4105VEQ Cold shock protein VAA049_1733 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) VAA049_1735 ENOG4108JUA Transcriptional regulator VAA049_1736 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) VAA049_1737 ENOG4105D9N nucleoside VAA049_174 ENOG4108BY5 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) VAA049_1740 ENOG41069D7 Methyl-accepting chemotaxis VAA049_1741 ENOG4105C7R Atpase associated with various cellular activities aaa_3 VAA049_1745 ENOG4107QVM von Willebrand factor, type A VAA049_1748 ENOG4105VEQ Cold shock protein VAA049_1749 ENOG4105BZU Histidine kinase VAA049_175 ENOG4105U1E general secretion pathway protein M VAA049_1751 ENOG4105VRT cytoplasmic protein VAA049_1753 ENOG4105C0F tryptophanase EC 4.1.99.1 VAA049_1754 ENOG4105CIC tryptophan-specific transport protein VAA049_1755 ENOG4105Q9Y Universal stress protein VAA049_1757 ENOG4105D65 subunit l VAA049_1758 ENOG4105MKQ Monovalent cation H antiporter subunit C VAA049_1759 ENOG4108JPZ Monovalent cation H antiporter subunit D VAA049_176 ENOG4105PIC general secretion pathway protein N VAA049_1760 ENOG4105SC1 monovalent cation H antiporter subunit E VAA049_1761 ENOG41080TA Multiple resistance and ph regulation protein f VAA049_1762 ENOG4105KJM monovalent cation h antiporter subunit g VAA049_1764 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) VAA049_1766 ENOG4105D5U fad dependent oxidoreductase VAA049_1769 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VAA049_177 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase VAA049_1770 ENOG4105CQZ Histidine kinase VAA049_1773 ENOG4105CXY transporter VAA049_1774 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase VAA049_1776 ENOG4105BZU Histidine kinase VAA049_1777 ENOG4105ETE Transcriptional regulator (LacI family VAA049_1778 ENOG4108RVA ribokinase VAA049_1779 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator VAA049_178 ENOG4107RK2 ADP-ribose diphosphatase NudE VAA049_1780 ENOG4105CNN ABC, transporter VAA049_1781 ENOG4105C2J ABC transporter VAA049_1782 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) VAA049_1785 ENOG4108J1Q VAA049_1786 ENOG4105CS6 Rhs element vgr protein VAA049_179 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) VAA049_1791 ENOG4108JUB Transcriptional regulator VAA049_1792 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit VAA049_18 ENOG4105CM2 brancheD-chain amino acid aminotransferase VAA049_180 ENOG4105MJ2 Competence protein VAA049_1804 ENOG4105D3G Pseudouridine synthase VAA049_1806 ENOG4107VXZ Hydrolase VAA049_1807 ENOG4105BZU Histidine kinase VAA049_1809 ENOG4105D9R oxidoreductase VAA049_181 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) VAA049_1810 ENOG4107RH7 Nicotinate phosphoribosyltransferase VAA049_1818 ENOG4105CK2 sodium dicarboxylate symporter VAA049_1822 ENOG4108Z4X TRANSCRIPTIONal VAA049_1823 ENOG4105E5M Multidrug resistance protein D VAA049_1824 ENOG4105EQ2 LysR family Transcriptional regulator VAA049_1826 ENOG4105BZU Histidine kinase VAA049_1827 ENOG4105DR5 peptidase VAA049_1829 ENOG4105CHH sulfate transporter VAA049_183 ENOG4105BZM domain protein VAA049_1830 ENOG4105DWD nucleoside recognition domain protein VAA049_1832 ENOG4105BZU Histidine kinase VAA049_1833 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) VAA049_1834 ENOG4105E2Z phosphate ABC transporter (Permease VAA049_1835 ENOG4105C8U phosphate abc transporter VAA049_1836 ENOG4105CVA phosphate VAA049_184 ENOG4108RRZ Transcription elongation factor GreB VAA049_1842 ENOG4105CUG Oligopeptidase b VAA049_1843 ENOG4105C1J atp-dependent rna helicase VAA049_1845 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein VAA049_1846 ENOG4105CVP deoxyribo-dipyrimidine photolyase VAA049_1848 ENOG4107SEY Conserved Protein VAA049_1849 ENOG4105D3A purine nucleoside phosphorylase DeoD-type VAA049_1852 ENOG4106TD9 Diguanylate cyclase VAA049_1853 ENOG4105KK7 inner membrane protein YiaW VAA049_1854 ENOG4105EFX secretion protein, HlyD family VAA049_1857 ENOG4105YE1 PilZ domain VAA049_1858 ENOG4105D6U Sodium Glutamate Symporter VAA049_1863 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) VAA049_1864 ENOG4105EYK Phosphatidylglycerophosphatase B VAA049_1868 ENOG4105C8Q Methyl-accepting chemotaxis VAA049_187 ENOG4105C2J ABC transporter VAA049_1872 ENOG4108Q67 UPF0319 protein VAA049_1873 ENOG4105C8P )-transporter VAA049_1875 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) VAA049_188 ENOG4105CNN ABC, transporter VAA049_1880 ENOG4105CS6 Rhs element vgr protein VAA049_1881 ENOG4108WC9 type VI secretion system effector, hcp1 family VAA049_1882 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) VAA049_1883 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) VAA049_1884 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) VAA049_1885 ENOG41061ZR Transcriptional regulator VAA049_1886 ENOG4108YYI Protein of unknown function (DUF2810) VAA049_1887 ENOG4105C8Q Methyl-accepting chemotaxis VAA049_1888 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase VAA049_1889 ENOG4105CDY transcriptional regulatory protein VAA049_189 ENOG4105D17 glycoside hydrolase, family 3 domain protein VAA049_1895 ENOG4106RMF ParB family VAA049_1896 ENOG4107RUE extracellular solute-binding protein family 1 VAA049_1897 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) VAA049_1901 ENOG4105EMU Dehydrogenase VAA049_1903 ENOG4105XJC Two component transcriptional regulator (Winged helix family VAA049_1904 ENOG4105DHQ Histidine kinase VAA049_1905 ENOG4105DIJ Phosphoethanolamine transferase VAA049_1906 ENOG4108JQ6 ABC transporter VAA049_1907 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VAA049_1908 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component VAA049_1911 ENOG4108VYJ response regulator receiver protein VAA049_1912 ENOG4105CBS Chea signal transduction histidine kinase VAA049_1913 ENOG4108V3W Chemotaxis protein, CheW VAA049_1914 ENOG4108V3W Chemotaxis protein, CheW VAA049_1915 ENOG4105C8Q Methyl-accepting chemotaxis VAA049_1916 ENOG4105BZU Histidine kinase VAA049_1917 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) VAA049_1918 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) VAA049_1919 ENOG4105C8Q Methyl-accepting chemotaxis VAA049_192 ENOG4105DPZ Two component transcriptional regulator (Winged helix family VAA049_1923 ENOG4108JJA ABC, transporter VAA049_1926 ENOG4107QZV Type I secretion membrane fusion protein VAA049_1927 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) VAA049_1929 ENOG4105E6M Sulphatase-modifying factor protein VAA049_193 ENOG4105E0F Histidine kinase VAA049_1932 ENOG4105C26 Dehydrogenase VAA049_1934 ENOG4105CK7 Sodium proline symporter VAA049_1936 ENOG4105C8Q Methyl-accepting chemotaxis VAA049_1937 ENOG4105EW9 transcriptional regulator AsnC family VAA049_1938 ENOG4107RGH Aldehyde dehydrogenase VAA049_1939 ENOG4105CXN decarboxylase VAA049_194 ENOG4105C2W permease VAA049_1940 ENOG4105D5Q Arginine ornithine antiporter VAA049_1941 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) VAA049_1943 ENOG4105JQN Transcriptional regulator VAA049_1944 ENOG4105EMU Dehydrogenase VAA049_1945 ENOG41069D7 Methyl-accepting chemotaxis VAA049_1946 ENOG4105JQN Transcriptional regulator VAA049_1947 ENOG4108RYK Nad-dependent epimerase dehydratase VAA049_1949 ENOG4108W2Y isochorismatase VAA049_195 ENOG4105CB5 ATP-dependent DNA helicase recG VAA049_1952 ENOG4108KTG Membrane protein, drug metabolite transporter VAA049_1956 ENOG4105EP9 oxidoreductase VAA049_1957 ENOG4105E61 Mannitol repressor protein VAA049_1958 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase VAA049_1959 ENOG4105CTS PTS system mannitol-specific VAA049_196 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) VAA049_1960 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain VAA049_1961 ENOG4105EZ7 amino acid ABC transporter VAA049_1962 ENOG4106TNF Periplasmic binding protein VAA049_1964 ENOG4105CDA abc transporter atp-binding protein VAA049_1965 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) VAA049_1967 ENOG4105C8Q Methyl-accepting chemotaxis VAA049_197 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) VAA049_1970 ENOG4108N3W hemolysin secretion protein VAA049_1973 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) VAA049_1974 ENOG4107W52 maltose operon periplasmic protein VAA049_1976 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) VAA049_198 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) VAA049_1981 ENOG4108VGI doxx family VAA049_1982 ENOG4105D03 DNA-3-methyladenine glycosylase II VAA049_1983 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) VAA049_1985 ENOG4107QPK )-transporter VAA049_1986 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism VAA049_1987 ENOG4105DN9 Na H antiporter VAA049_1988 ENOG4106YYS transcriptional regulatory protein VAA049_1989 ENOG41074DU domain protein VAA049_199 ENOG4105EX9 Membrane VAA049_1990 ENOG4108P2H Inner membrane protein YjiG VAA049_1992 ENOG4108SXK Transporter Drug Metabolite Exporter family VAA049_1994 ENOG4108ZHJ Organic hydroperoxide resistance protein VAA049_1995 ENOG4105K56 Transcriptional regulator VAA049_2 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) VAA049_200 ENOG4107QN1 sodium solute VAA049_2002 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase VAA049_2004 ENOG4105BZ1 (ABC) transporter VAA049_2006 ENOG4105C1J atp-dependent rna helicase VAA049_2008 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor VAA049_2010 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) VAA049_2012 ENOG4105DMF Dehydrogenase VAA049_2013 ENOG4105DAA L-lactate VAA049_2014 ENOG4105CC0 LysR family Transcriptional regulator VAA049_2016 ENOG4105C8Q Methyl-accepting chemotaxis VAA049_2017 ENOG4105E89 ABC transporter VAA049_2018 ENOG4108JQ5 ABC transporter VAA049_202 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) VAA049_2020 ENOG4105DAN ATP-dependent protease VAA049_2021 ENOG4105C8Q Methyl-accepting chemotaxis VAA049_2023 ENOG4105E5W Transporter VAA049_2025 ENOG4105NBK UPF0345 protein VAA049_2026 ENOG4105EUB pirin domain protein VAA049_2028 ENOG4108K0B C-di-gmp phosphodiesterase VAA049_2029 ENOG4105ETT transcriptional Regulator, LysR family VAA049_2033 ENOG4105BZU Histidine kinase VAA049_2036 ENOG4106TD9 Diguanylate cyclase VAA049_2037 ENOG4105RV9 Transcriptional regulator VAA049_2038 ENOG4107R88 Chemotaxis protein (CheV) VAA049_2039 ENOG4105KQ5 peptidylprolyl cis-trans isomerase VAA049_204 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) VAA049_2040 ENOG41086KC Transcriptional regulator VAA049_2041 ENOG4105K8R UPF0145 protein VAA049_2044 ENOG4108HK0 -acetyltransferase VAA049_2045 ENOG4108IJ9 (ABC) transporter VAA049_2046 ENOG4107FKK extracellular solute-binding protein family 1 VAA049_2047 ENOG4105D56 permease protein VAA049_2048 ENOG4105EG2 ABC transporter, permease VAA049_2051 ENOG4105E98 transcriptional regulator DeoR family VAA049_2052 ENOG4105BZU Histidine kinase VAA049_2057 ENOG4105VEQ Cold shock protein VAA049_2059 ENOG4108ESY Metal dependent phosphohydrolase VAA049_206 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter VAA049_2060 ENOG4105CKW Inner membrane protein yedI VAA049_2061 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) VAA049_2063 ENOG4105KAF membrAne VAA049_2065 ENOG4105EKE dihydroorotase VAA049_2066 ENOG4105QVC MOSC domain-containing protein VAA049_2066 ENOG4105QVC MOSC domain-containing protein VAA049_2067 ENOG4105C8Q Methyl-accepting chemotaxis VAA049_207 ENOG4108IJ0 Aspartate ammonia-lyase VAA049_2073 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) VAA049_2074 ENOG4105EHG Permease protein VAA049_2075 ENOG4107R4I Periplasmic binding protein VAA049_2076 ENOG4106GFD transport protein VAA049_2077 ENOG41090AP transport protein VAA049_2078 ENOG4105WQ5 TonB family VAA049_2079 ENOG4105D4P Coproporphyrinogen iii oxidase VAA049_208 ENOG4105BZU Histidine kinase VAA049_2080 ENOG41090JE Utilization Protein VAA049_2081 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related VAA049_2082 ENOG4108NVR Methyl-accepting chemotaxis VAA049_2083 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR VAA049_2084 ENOG4105C6Z Gluconate VAA049_2085 ENOG4105BZW Glycerate kinase VAA049_209 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 VAA049_2090 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) VAA049_2091 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) VAA049_2092 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase VAA049_2093 ENOG4105DHT Metal Dependent Phosphohydrolase VAA049_2094 ENOG4107SSZ Phosphatase VAA049_2098 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase VAA049_2099 ENOG4105EXG Transcriptional regulator VAA049_21 ENOG4105C0P Mg chelatase subunit ChlI VAA049_210 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) VAA049_2100 ENOG4108IQK o-acetylhomoserine VAA049_2101 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) VAA049_2102 ENOG4105CPQ Dehydrogenase VAA049_2112 ENOG4105W8I Transcriptional regulator VAA049_2113 ENOG4105BZC d-serine deaminase VAA049_2116 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii VAA049_2117 ENOG4105C4M (Ubiquinol oxidase) subunit I VAA049_2118 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family VAA049_2119 ENOG41061WM D-Alanyl-D-Alanine VAA049_212 ENOG4105E0F Histidine kinase VAA049_2122 ENOG4105EIF outer membrane protein W VAA049_2123 ENOG4105D4Y metalloprotease VAA049_2124 ENOG4107SDU Methyl-accepting chemotaxis VAA049_2125 ENOG4108M0H Extracellular lipase VAA049_2126 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation VAA049_2127 ENOG4107T9C Alpha amylase catalytic region VAA049_2128 ENOG4107RGM aldo keto reductase VAA049_213 ENOG4105E3W Two component transcriptional regulator (Winged helix family VAA049_2130 ENOG4106TD9 Diguanylate cyclase VAA049_2131 ENOG4105DVH amino acid VAA049_2135 ENOG4107YWA deoxycytidylate deaminase VAA049_2136 ENOG4108UKZ OsmC family VAA049_2137 ENOG4105C37 (CBS) domain VAA049_2138 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) VAA049_2141 ENOG4105EGI Transcriptional regulator VAA049_2142 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) VAA049_2145 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) VAA049_2146 ENOG4105MIR Phenylalanine 4-monooxygenase VAA049_2147 ENOG41090A4 Pterin carbinolamine dehydratase VAA049_2148 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase VAA049_2149 ENOG4108JPW Aminotransferase VAA049_215 ENOG41076HS cation diffusion facilitator family transporter VAA049_2150 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) VAA049_2151 ENOG4105CZK Aspartate kinase VAA049_2153 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) VAA049_2154 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) VAA049_2155 ENOG4105CJW magnesium transporter VAA049_2157 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) VAA049_2158 ENOG4105CYW agmatinase VAA049_216 ENOG4105CTQ phosphohexokinase VAA049_2160 ENOG4105D4Y metalloprotease VAA049_2161 ENOG4108M1A Chitin-binding protein VAA049_2162 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein VAA049_2164 ENOG4105CVA phosphate VAA049_2166 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) VAA049_2167 ENOG4105C1J atp-dependent rna helicase VAA049_2169 ENOG4105E0M Sulfatase VAA049_217 ENOG4105CBT Fructose-1,6-bisphosphatase VAA049_2170 ENOG4107RE1 Inosine-guanosine kinase VAA049_2173 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) VAA049_2177 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) VAA049_218 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) VAA049_2180 ENOG4105RKW reductase (By VAA049_2182 ENOG4108I0Y (ABC) transporter VAA049_2183 ENOG4105CV6 ABC transporter, permease VAA049_2184 ENOG4105C6Y Udp-glucose 6-dehydrogenase VAA049_2186 ENOG4107R7A Allophanate hydrolase subunit 2 VAA049_2188 ENOG4105E7W lamb ycsf family protein VAA049_2189 ENOG4105CMR udp-glucose 4-epimerase VAA049_219 ENOG4105SYT Methylenetetrahydrofolate reductase VAA049_2190 ENOG4108N3W hemolysin secretion protein VAA049_2191 ENOG4105E0U tyrosine-specific transport protein VAA049_2193 ENOG4108ZYK Acyl carrier protein phosphodiesterase VAA049_2194 ENOG4105C1J atp-dependent rna helicase VAA049_2195 ENOG4108IG5 Transcriptional regulator VAA049_2196 ENOG4106RE7 Cytochrome VAA049_2197 ENOG4105C5W Aldolase VAA049_2198 ENOG4108YZ4 nudix hydrolase VAA049_22 ENOG4106HNH Acyl-transferase VAA049_220 ENOG4105CFH Aspartokinase VAA049_2200 ENOG4105EV2 VWA domain protein interacting with AAA ATPase VAA049_2202 ENOG4105E5Z arginine transporter ATP-binding subunit VAA049_2203 ENOG4106PMH Extracellular solute-binding protein family 3 VAA049_2204 ENOG4105GBT ABC transporter VAA049_2205 ENOG4105DMR ABC, transporter VAA049_2206 ENOG4105DUM transcriptional regulator, lysR family VAA049_221 ENOG4105C28 cystathionine VAA049_2212 ENOG4105K63 Thioredoxin VAA049_2213 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) VAA049_2214 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) VAA049_2216 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A VAA049_2217 ENOG4108QGH periplasmic VAA049_2219 ENOG4105BZU Histidine kinase VAA049_222 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) VAA049_2224 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) VAA049_2225 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein VAA049_2226 ENOG4105E0C molybdate abc transporter VAA049_2227 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) VAA049_223 ENOG4105C6K Malic enzyme VAA049_2233 ENOG4105EM2 membrane VAA049_2234 ENOG41088T4 Helicase IV VAA049_2237 ENOG41080IJ Diacylglycerol kinase VAA049_2238 ENOG4108RWI nicotinamidase VAA049_2239 ENOG4108Z5K methylglyoxal synthase VAA049_224 ENOG4105VFB Binds the 23S rRNA (By similarity) VAA049_2240 ENOG4108SV3 Tmao reductase system periplasmic protein tort VAA049_2241 ENOG4105BZU Histidine kinase VAA049_2242 ENOG4105CA9 Pyruvate kinase VAA049_2243 ENOG4105CXY transporter VAA049_2245 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC VAA049_2248 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta VAA049_2249 ENOG4108I6A alcohol dehydrogenase VAA049_225 ENOG4105C25 Primosomal protein n' VAA049_2251 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) VAA049_2252 ENOG4105BZU Histidine kinase VAA049_2255 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) VAA049_2256 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) VAA049_2258 ENOG4105CHU acetyl-coa acetyltransferase VAA049_226 ENOG4105ETE Transcriptional regulator (LacI family VAA049_2260 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class VAA049_2261 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) VAA049_2262 ENOG4107RCV ABC transporter, permease VAA049_2263 ENOG4105C4Y ABC transporter VAA049_2264 ENOG4105CXY transporter VAA049_2265 ENOG4105BZU Histidine kinase VAA049_2266 ENOG4108KX4 response regulator VAA049_2267 ENOG4105DHT Metal Dependent Phosphohydrolase VAA049_227 ENOG41063M6 Cell Division Protein VAA049_2271 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) VAA049_2274 ENOG4105BZU Histidine kinase VAA049_2275 ENOG4105WH1 Two component transcriptional regulator luxr family VAA049_2276 ENOG4105EJQ L-serine dehydratase VAA049_2277 ENOG4105CEE C4-dicarboxylate transporter VAA049_2278 ENOG4108N3W hemolysin secretion protein VAA049_2279 ENOG4107VXZ Hydrolase VAA049_228 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) VAA049_2280 ENOG4108V1T peptidylprolyl cis-trans isomerase VAA049_2281 ENOG4108ZG0 Ompa motb domain protein VAA049_2282 ENOG4108NVR Methyl-accepting chemotaxis VAA049_2283 ENOG4105C6V Glycerol-3-phosphate dehydrogenase VAA049_2284 ENOG4105D7K pfkb domain protein VAA049_2285 ENOG4107R3K hydrolase VAA049_2286 ENOG4105ETE Transcriptional regulator (LacI family VAA049_2287 ENOG4105C5Y PTS System VAA049_229 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) VAA049_2296 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase VAA049_2298 ENOG41080HT Transcriptional regulator, arsr family VAA049_23 ENOG4108Z33 Thiol disulfide Interchange Protein VAA049_230 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase VAA049_2303 ENOG4108RCM Nitroreductase VAA049_2304 ENOG4105ETT transcriptional Regulator, LysR family VAA049_2305 ENOG41067V3 Antibiotic biosynthesis monooxygenase VAA049_2307 ENOG4105RA2 Membrane VAA049_231 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) VAA049_2310 ENOG4105C5I Dehydrogenase VAA049_2316 ENOG4105CV1 Transketolase (EC 2.2.1.1) VAA049_2317 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) VAA049_2318 ENOG4107RHR regulatoR VAA049_2320 ENOG4105KHC sulfurtransferase VAA049_2322 ENOG4105D06 uba thif-type nad fad binding protein VAA049_2323 ENOG4105CVM Molybdenum cofactor synthesis domain protein VAA049_2324 ENOG4105EUJ GTP cyclohydrolase i VAA049_2325 ENOG4105E0X reductase VAA049_2326 ENOG4105CKU formyltetrahydrofolate synthetase VAA049_2327 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) VAA049_2328 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain VAA049_233 ENOG4105CP7 Triose-phosphate isomerase VAA049_2330 ENOG4105PAD Hydrolase VAA049_2331 ENOG4105NXH GreA GreB family elongation factor VAA049_2332 ENOG4108KAZ Involved in phosphonate degradation (By similarity) VAA049_2333 ENOG4108JPW Aminotransferase VAA049_2334 ENOG4107STF Involved in phosphonate degradation (By similarity) VAA049_2337 ENOG4107RCV ABC transporter, permease VAA049_2340 ENOG4105DUX Transporter VAA049_2345 ENOG4105E43 Extracellular solute-binding protein, family 5 VAA049_2346 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component VAA049_2347 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component VAA049_2348 ENOG4108JQ5 ABC transporter VAA049_2349 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) VAA049_2352 ENOG4105CYM Glutathione S-transferase VAA049_2356 ENOG4105KA0 thioesterase Superfamily protein VAA049_2360 ENOG4105CWB LysR family transcriptional Regulator VAA049_2361 ENOG4105CD5 CoA-binding domain protein VAA049_2363 ENOG4105CPF Cell wall formation (By similarity) VAA049_2365 ENOG4108ZJT translation initiation factor, Sui1 VAA049_238 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) VAA049_2380 ENOG4105CK6 Two component transcriptional regulator (Winged helix family VAA049_2382 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) VAA049_2383 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) VAA049_2387 ENOG4105BZU Histidine kinase VAA049_2388 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) VAA049_239 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) VAA049_2390 ENOG4105BZU Histidine kinase VAA049_2396 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA VAA049_2398 ENOG4105DU1 integral membrane protein, terc VAA049_24 ENOG4105E27 serine threonine protein kinase VAA049_2400 ENOG4105CGH 5'-nucleotidase VAA049_2401 ENOG4105CPB ATP-dependent endonuclease of the OLD family VAA049_2402 ENOG4108UQ5 membrane protein YcdZ VAA049_2403 ENOG4105DUM transcriptional regulator, lysR family VAA049_2404 ENOG4105TMB Formate nitrite transporter VAA049_2406 ENOG4105DS1 cytochrome b561 VAA049_2408 ENOG4105EPM Diguanylate phosphodiesterase VAA049_241 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein VAA049_2410 ENOG4108RHM integral membrane protein VAA049_2411 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) VAA049_2412 ENOG4105EEX Two component transcriptional regulator (Winged helix family VAA049_2413 ENOG4105C08 Histidine kinase VAA049_2414 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) VAA049_2415 ENOG4105DFH Transport of potassium into the cell (By similarity) VAA049_2416 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) VAA049_2417 ENOG4105CKI cobalamin synthesis protein VAA049_2418 ENOG4105CMQ Chloride channel VAA049_242 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) VAA049_2420 ENOG4107KBT 8-Amino-7-oxononanoate synthase VAA049_2421 ENOG4108MGY Histidine kinase VAA049_2422 ENOG4105EYH Exonuclease VAA049_2423 ENOG4107RFY SbcCD D subunit VAA049_2424 ENOG4107B7Y DNA-binding transcriptional regulator FruR VAA049_2425 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein VAA049_2426 ENOG4105DE4 1-phosphofructokinase VAA049_2427 ENOG4105DM4 PTS System VAA049_2428 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) VAA049_2429 ENOG4105CGF Aromatic amino acid aminotransferase VAA049_243 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) VAA049_2430 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) VAA049_2431 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase VAA049_2433 ENOG4108J1Q VAA049_244 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) VAA049_2449 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A VAA049_245 ENOG4105E33 succinate dehydrogenase VAA049_2457 ENOG4108J1Q VAA049_2467 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase VAA049_247 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) VAA049_2474 ENOG4108UW5 maltose o-acetyltransferase VAA049_2479 ENOG4105KD7 acetyltransferase VAA049_248 ENOG4107YZP Rhodanese domain protein VAA049_2481 ENOG41068WN VAA049_2483 ENOG4107TIF Phenazine biosynthesis protein, PhzF family VAA049_249 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) VAA049_2492 ENOG4105D9U N-acetyltransferase VAA049_2498 ENOG4108J1Q VAA049_250 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase VAA049_2501 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) VAA049_2502 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) VAA049_2505 ENOG4108YZT Adenosylcobinamide kinase VAA049_2506 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) VAA049_2507 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) VAA049_2508 ENOG4105E0X reductase VAA049_2509 ENOG4108ETY sodium dicarboxylate symporter VAA049_251 ENOG4105D7W serine acetyltransferase VAA049_2510 ENOG4105CJB Exodeoxyribonuclease I VAA049_2512 ENOG41067MG lrgb family VAA049_2513 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) VAA049_2515 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR VAA049_2516 ENOG4105FQ6 thiopurine methyltransferase VAA049_2519 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) VAA049_2520 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) VAA049_2521 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) VAA049_2522 ENOG4105BZU Histidine kinase VAA049_2529 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) VAA049_253 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) VAA049_2530 ENOG4105WH1 Two component transcriptional regulator luxr family VAA049_2531 ENOG4105BZU Histidine kinase VAA049_2532 ENOG4105CQ2 DNA polymerase VAA049_2534 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) VAA049_2537 ENOG4105CZE histidine utilization repressor VAA049_2538 ENOG4105CI2 imidazolone-5-propionate hydrolase VAA049_2539 ENOG41088SP formiminoglutamate hydrolase VAA049_254 ENOG4105CWC Acetylornithine deacetylase VAA049_2540 ENOG4105CGP Urocanate hydratase VAA049_2541 ENOG4105C84 Histidine ammonia-lyase VAA049_2543 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap VAA049_2545 ENOG4105CQB FAD linked oxidase domain protein VAA049_2548 ENOG4108ZG0 Ompa motb domain protein VAA049_255 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase VAA049_2552 ENOG4105C8V SAICAR synthetase VAA049_2554 ENOG4107R1I NAD-dependent malic enzyme VAA049_2556 ENOG4107GZ4 SanA protein VAA049_2557 ENOG4105BZU Histidine kinase VAA049_2558 ENOG4105C9B Cysteine desulfurase VAA049_256 ENOG4105CAS nag kinase VAA049_2560 ENOG4105C3M thioredoxin reductase VAA049_2561 ENOG4108JJ9 ABC, transporter VAA049_2562 ENOG4108JJ8 (ABC) transporter VAA049_2563 ENOG4105FE9 pseudouridine synthase VAA049_2564 ENOG4107RTD sua5 ycio yrdc ywlc family protein VAA049_2565 ENOG4105DB7 PHP domain protein VAA049_2566 ENOG4105CRQ synthase (Component I) VAA049_2567 ENOG4105DDQ anthranilate synthase VAA049_2568 ENOG4108I0Q anthranilate phosphoribosyltransferase VAA049_2569 ENOG4105DK0 Indole-3-glycerol phosphate synthase VAA049_257 ENOG4105CDH Citrulline--aspartate ligase VAA049_2570 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) VAA049_2571 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) VAA049_2572 ENOG4105CK2 sodium dicarboxylate symporter VAA049_2573 ENOG4107104 thymidine kinase VAA049_2574 ENOG4105C9M aspartyl-trna synthetase VAA049_2575 ENOG41081XQ Conserved Protein VAA049_2576 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) VAA049_2577 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) VAA049_2578 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) VAA049_258 ENOG4105CH7 arginosuccinase VAA049_2581 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) VAA049_2583 ENOG4105CUX Signal transduction histidine kinase VAA049_2588 ENOG4105DWU Membrane VAA049_2590 ENOG4105DY8 decarboxylase VAA049_2591 ENOG4106KNT transcriptional regulator VAA049_2592 ENOG4108EKI Dehydrogenase VAA049_2593 ENOG41090BQ Glutaredoxin VAA049_2595 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit VAA049_2596 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) VAA049_2597 ENOG4105VEQ Cold shock protein VAA049_2599 ENOG4108R99 pseudouridine synthase VAA049_26 ENOG4105PC1 Conserved Protein VAA049_260 ENOG4107QN2 dihydrolipoyl dehydrogenase VAA049_2600 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase VAA049_2601 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) VAA049_2602 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase VAA049_2603 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) VAA049_2604 ENOG4105ECC imidazole-glycerol-phosphate dehydratase VAA049_2605 ENOG4105CIH Imidazole acetol-phosphate transaminase VAA049_2606 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) VAA049_2607 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) VAA049_2608 ENOG4107S6Z Na H antiporter VAA049_261 ENOG4105EHV domain protein VAA049_2610 ENOG4107RE1 Inosine-guanosine kinase VAA049_2611 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) VAA049_2612 ENOG41075W9 High frequency lysogenization protein HflD homolog VAA049_2613 ENOG4107QTF adenylosuccinate lyase VAA049_2615 ENOG4105RHG VAA049_2617 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase VAA049_2620 ENOG4107FW0 short-chain dehydrogenase reductase VAA049_2622 ENOG4105D0M Protease HtpX homolog VAA049_2624 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) VAA049_2625 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) VAA049_2626 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) VAA049_2627 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) VAA049_2628 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) VAA049_2629 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) VAA049_263 ENOG4108JQC penicillin-binding protein 1A VAA049_2630 ENOG4105D1H recombination factor protein RarA VAA049_2632 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving VAA049_2633 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) VAA049_2634 ENOG4105BZU Histidine kinase VAA049_2635 ENOG4108JJB ABC transporter VAA049_2636 ENOG4105C7J ABC transporter, permease VAA049_2638 ENOG4105VYA Uncharacterized conserved protein (DUF2132) VAA049_2639 ENOG4105PQ6 UPF0208 membrane protein VAA049_2640 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) VAA049_2641 ENOG4108DNC Involved in acetate metabolism (By similarity) VAA049_2642 ENOG4105CHF Glutathione S-transferase VAA049_2645 ENOG4105C3U ABC transporter VAA049_2646 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VAA049_2647 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component VAA049_2648 ENOG4107QSI ABC, transporter VAA049_2651 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VAA049_2652 ENOG4105BZU Histidine kinase VAA049_2653 ENOG4105BZU Histidine kinase VAA049_2654 ENOG4105BZU Histidine kinase VAA049_2656 ENOG4107YTP response regulator receiver protein VAA049_2659 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) VAA049_2662 ENOG4108V1U phospholipid-binding protein VAA049_2667 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase VAA049_2668 ENOG41082YX Transcriptional regulator, arsr family VAA049_2669 ENOG4105CZN Potassium uptake protein VAA049_2673 ENOG4105EEX Two component transcriptional regulator (Winged helix family VAA049_2674 ENOG4105C08 Histidine kinase VAA049_2675 ENOG41061MD high-affinity nickel-transporter VAA049_2676 ENOG41090EM Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter VAA049_2677 ENOG4108J1Q VAA049_268 ENOG4105E4G Type IV pilus VAA049_2683 ENOG4108J1Q VAA049_2685 ENOG4105BZU Histidine kinase VAA049_2689 ENOG4105C29 acyl-CoA thioesterase VAA049_269 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) VAA049_2690 ENOG4108XM1 transcriptional regulator AsnC family VAA049_2692 ENOG4105ERU peptidase VAA049_2693 ENOG4105UBK short-chain dehydrogenase reductase VAA049_2695 ENOG4105KRS Proteinase inhibitor VAA049_2696 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) VAA049_2697 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) VAA049_2698 ENOG4107QMP dna polymerase iii subunits gamma and tau VAA049_2699 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) VAA049_27 ENOG4108N23 SpoOM-related protein VAA049_270 ENOG4105D49 3-dehydroquinate synthase VAA049_2700 ENOG4105WD1 Membrane VAA049_2702 ENOG4105I93 response regulator VAA049_2703 ENOG4105EJC lysr family transcriptional regulator VAA049_2704 ENOG41069NU Nitroreductase VAA049_2705 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase VAA049_2706 ENOG4105CHU acetyl-coa acetyltransferase VAA049_2709 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation VAA049_2710 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation VAA049_2712 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase VAA049_2713 ENOG4108J1Q VAA049_2714 ENOG4108GAE asmA family VAA049_2715 ENOG4105DBI uridine monophosphokinase VAA049_2716 ENOG4105D1F ATP-binding protein VAA049_2717 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) VAA049_2719 ENOG4108I5U Uridine phosphorylase VAA049_272 ENOG4105DFE Dna adenine methylase VAA049_2722 ENOG4105BZU Histidine kinase VAA049_2723 ENOG4108ZAF Molybdopterin VAA049_2724 ENOG4105M00 molybdopterin converting factor, subunit 1 VAA049_2725 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) VAA049_2726 ENOG4108RIR Molybdenum cofactor biosynthesis protein VAA049_2727 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) VAA049_2729 ENOG4105CHW UPF0052 protein VAA049_273 ENOG4105DJV ribulose-phosphate 3-epimerase VAA049_2730 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VAA049_2731 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) VAA049_2734 ENOG4108R3D Electron transport complex VAA049_2736 ENOG4105D6A Electron transport complex VAA049_2737 ENOG4108UQQ Electron transport complex VAA049_2738 ENOG4105DZB Electron transport complex VAA049_2739 ENOG4105CSM endonuclease III VAA049_274 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) VAA049_2740 ENOG4108UYE Lactoylglutathione lyase VAA049_2741 ENOG4106WH9 Protein of unknown function (DUF2753) VAA049_2742 ENOG4105EIY sodium-type flagellar protein motY VAA049_2743 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) VAA049_2744 ENOG4105D3Y Na H antiporter VAA049_2745 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase VAA049_2746 ENOG4105E96 Colicin v production protein VAA049_2747 ENOG4108S3P Sporulation domain protein VAA049_2748 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase VAA049_2749 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) VAA049_275 ENOG4105C31 Tryptophanyl-tRNA synthetase VAA049_2750 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) VAA049_2752 ENOG4105CX6 glutaminyL-tRNA synthetase VAA049_2753 ENOG4105CI1 PTS System VAA049_2754 ENOG4105CE4 GlcNAc 6-P deacetylase VAA049_2755 ENOG4105E2R ROK family VAA049_2756 ENOG4105CKD glutathione-regulated potassium-efflux system protein VAA049_2757 ENOG4105CAQ asparagine synthetase VAA049_2758 ENOG4105MDZ Transcriptional activator rfaH VAA049_2759 ENOG4105DUX Transporter VAA049_2760 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) VAA049_2761 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) VAA049_2762 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) VAA049_2763 ENOG4108TU9 TRANSCRIPTIONal VAA049_2766 ENOG4108RE9 Phosphodiesterase VAA049_2767 ENOG4105ECP epimerase VAA049_2768 ENOG4105E1F short-chain dehydrogenase reductase VAA049_2769 ENOG4107QR8 Thioredoxin VAA049_2770 ENOG4107QX8 SPFH domain, Band 7 family protein VAA049_2771 ENOG4105G5H Membrane VAA049_2772 ENOG4108Z6Z Transcriptional regulator VAA049_2774 ENOG41081QG Porin Gram-negative type VAA049_2775 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) VAA049_2776 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) VAA049_2777 ENOG4105EXN Sulfate transport protein CysZ VAA049_2778 ENOG4105C6T cysteine synthase VAA049_2779 ENOG4105KZ7 phosphocarrier protein hpr VAA049_278 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) VAA049_2781 ENOG4105C5Y PTS System VAA049_2782 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family VAA049_2783 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) VAA049_2784 ENOG4105C9A Phoh family VAA049_2785 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) VAA049_2786 ENOG4108JU5 Magnesium and cobalt efflux protein VAA049_2787 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) VAA049_2788 ENOG4107PAI alpha helical protein VAA049_2789 ENOG4105C8T Leucyl-tRNA synthetase VAA049_279 ENOG4105DDQ anthranilate synthase VAA049_2790 ENOG4108U2H Rare lipoprotein B VAA049_2791 ENOG4105DJF DNA polymerase III, delta' subunit VAA049_2792 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) VAA049_2793 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) VAA049_2794 ENOG4105CJN penicillin-binding protein VAA049_2795 ENOG4105CNI cell division protein FtsW VAA049_2796 ENOG4105K6T rare lipoprotein A VAA049_2797 ENOG4105DZ1 carboxypeptidase VAA049_2799 ENOG4108Z43 UPF0250 protein VAA049_28 ENOG4108UT2 hemolysin iii VAA049_280 ENOG4105C8Y Acetylornithine aminotransferase VAA049_2800 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) VAA049_2801 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) VAA049_2803 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) VAA049_2807 ENOG4105D75 Capsular exopolysaccharide family VAA049_2808 ENOG4105DAY polysaccharide export protein VAA049_2810 ENOG4105D3Q Sugar transferase VAA049_2813 ENOG4108MA4 Peptidase M66 VAA049_2816 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family VAA049_2825 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase VAA049_2827 ENOG4105BZS acriflavin resistance protein VAA049_2833 ENOG4105CG3 alpha amylase, catalytic region VAA049_2834 ENOG4105C5Y PTS System VAA049_2835 ENOG4105D4X repressor VAA049_2836 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase VAA049_2837 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) VAA049_2838 ENOG4108UMI ABC transporter, permease VAA049_2839 ENOG4105D01 (LipO)protein VAA049_284 ENOG4107RYR Transcriptional regulator, Crp Fnr family VAA049_2840 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein VAA049_2841 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) VAA049_2842 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) VAA049_2844 ENOG4105BZU Histidine kinase VAA049_2845 ENOG4105EWT decarboxylase family VAA049_2846 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease VAA049_2848 ENOG4105ETT transcriptional Regulator, LysR family VAA049_2849 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) VAA049_285 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) VAA049_2850 ENOG4106VK6 Flagellar motor protein VAA049_2851 ENOG4105E14 MotA TolQ exbB proton channel VAA049_2853 ENOG4105CTB Polyprenyl synthetase VAA049_2854 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) VAA049_2855 ENOG4105DR9 pseudouridine synthase VAA049_2856 ENOG4105WP7 tRNA pseudouridine synthase C VAA049_2858 ENOG4108428 Inherit from COG: -acetyltransferase VAA049_2861 ENOG4108UPT UPF0178 protein VAA049_2862 ENOG4105CFC Transporter VAA049_2864 ENOG4105NRA 50s ribosomal protein l31 type b VAA049_2865 ENOG4108R96 Methyltransferase, YaeB family VAA049_2866 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) VAA049_287 ENOG4105DNZ Alpha Beta Hydrolase VAA049_2870 ENOG4107QIK phosphoribosylformylglycinamidine synthase VAA049_2871 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) VAA049_2873 ENOG4108Z6B deaminase VAA049_2874 ENOG4105CFC Transporter VAA049_2880 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) VAA049_2881 ENOG4105CFG Acts as a chaperone (By similarity) VAA049_2882 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ VAA049_2883 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) VAA049_2884 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) VAA049_2885 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) VAA049_2886 ENOG4105VDB UPF0125 protein VAA049_2887 ENOG4108Z1B Cyclase dehydrase VAA049_2888 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) VAA049_2889 ENOG4105DZR Type I site-specific deoxyribonuclease VAA049_289 ENOG4105C5H ABC transporter VAA049_2890 ENOG4105EKX Restriction modification system DNA (Specificity VAA049_2891 ENOG4105CVR type I restriction-modification system VAA049_2894 ENOG4105DZ0 fad dependent oxidoreductase VAA049_2895 ENOG4108Z4U Ferredoxin VAA049_2898 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase VAA049_2899 ENOG4105YGP holo-ACP synthase CitX VAA049_290 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein VAA049_2900 ENOG4105CHY citrate lyase, alpha VAA049_2901 ENOG4105CI0 Citrate lyase VAA049_2902 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) VAA049_2903 ENOG4105DUA (citrate (pro-3S)-lyase ligase VAA049_2906 ENOG4107QSA Oxaloacetate decarboxylase VAA049_2907 ENOG4105D9Q decarboxylase (Beta subunit) VAA049_2908 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism VAA049_2909 ENOG4106YYS transcriptional regulatory protein VAA049_2912 ENOG4105F04 LysR family Transcriptional regulator VAA049_2913 ENOG4105MWK D-amino acid dehydrogenase, small subunit VAA049_2914 ENOG4105BZG amino acid carrier protein VAA049_2915 ENOG4105EUZ Beta-lactamase domain protein VAA049_2916 ENOG41064T2 transcriptional regulator, lysR family VAA049_2918 ENOG4105E0A ABC, transporter VAA049_2919 ENOG4105TVJ transport system, permease VAA049_2920 ENOG4105DQ5 transport system permease protein VAA049_2921 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein VAA049_2923 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase VAA049_2924 ENOG4105E4F Isochorismate synthase VAA049_2925 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase VAA049_2926 ENOG4105WQI isochorismatase VAA049_2927 ENOG4106HK8 GPR1 FUN34 yaaH family protein VAA049_2929 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) VAA049_293 ENOG4108YZY peptidylprolyl cis-trans isomerase VAA049_2930 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) VAA049_2932 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) VAA049_2934 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) VAA049_2935 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) VAA049_2936 ENOG4105N21 Membrane VAA049_2937 ENOG4105CUT histidyl-tRNA synthetase VAA049_2938 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) VAA049_294 ENOG4105D44 asparaginase VAA049_2941 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) VAA049_2942 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) VAA049_2943 ENOG4105WVQ Fe-S assembly protein IscX VAA049_2944 ENOG4108ZIT Ferredoxin, 2FE-2S VAA049_2947 ENOG4108Z4V iron-sulfur cluster assembly VAA049_2948 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins VAA049_2949 ENOG4105C3J Cysteine desulfurase VAA049_295 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis VAA049_2950 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family VAA049_2951 ENOG4105CVS RNA methyltransferase TrmH family, group 1 VAA049_2952 ENOG4105ECY inositol monophosphatase VAA049_2953 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) VAA049_2954 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) VAA049_2955 ENOG4105VIE preprotein translocase, subunit YajC VAA049_2956 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) VAA049_2957 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) VAA049_2958 ENOG4105W87 Cbs domain VAA049_2959 ENOG4108I9X Isocitrate lyase VAA049_296 ENOG4108UV7 flagellar protein motX VAA049_2960 ENOG4107QP3 malate synthase g VAA049_2961 ENOG4105C5Q Transcriptional regulator VAA049_2962 ENOG4105D3R alkyl hydroperoxide reductase VAA049_2963 ENOG4106N3A copper homeostasis protein cutc VAA049_2964 ENOG4105CSR polyphosphate kinase 2 VAA049_2966 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) VAA049_2967 ENOG4105E2Z phosphate ABC transporter (Permease VAA049_2968 ENOG4105C8U phosphate abc transporter VAA049_2969 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) VAA049_297 ENOG4105E68 Sulfatase VAA049_2970 ENOG4105C9X ppx gppa phosphatase VAA049_2972 ENOG4105BZU Histidine kinase VAA049_2973 ENOG4105CK6 Two component transcriptional regulator (Winged helix family VAA049_2974 ENOG4105DH7 May be involved in recombination (By similarity) VAA049_2975 ENOG4105CFP Peptidase U32 VAA049_2976 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding VAA049_298 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) VAA049_2984 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit VAA049_2985 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase VAA049_2986 ENOG4105C34 Pseudouridine synthase VAA049_2987 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane VAA049_2988 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA VAA049_299 ENOG4105C2N RNA methyltransferase TrmH family group 3 VAA049_2990 ENOG4107XW0 Spermidine putrescine ABC transporter periplasmic spermidine putrescine-binding protein VAA049_2991 ENOG4108K0B C-di-gmp phosphodiesterase VAA049_2992 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) VAA049_2993 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) VAA049_2994 ENOG4107SC1 transglycosylase VAA049_2995 ENOG4105C5H ABC transporter VAA049_2998 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) VAA049_2999 ENOG4108HRK Histidine kinase VAA049_3 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) VAA049_30 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) VAA049_300 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) VAA049_3000 ENOG4108NEV two component transcriptional regulator, LytTR family VAA049_3001 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) VAA049_3002 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) VAA049_3003 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate VAA049_3007 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) VAA049_3008 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase VAA049_3009 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) VAA049_301 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) VAA049_3010 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) VAA049_3011 ENOG4105DTN riboflavin biosynthesis protein ribF VAA049_3012 ENOG4105CJR Integral membrane protein (MviN VAA049_3013 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) VAA049_3014 ENOG41080HT Transcriptional regulator, arsr family VAA049_3015 ENOG41063Z6 transcriptional regulator, lysR family VAA049_3017 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) VAA049_3018 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) VAA049_3019 ENOG4105HF0 Membrane VAA049_302 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) VAA049_3020 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase VAA049_3021 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) VAA049_3022 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) VAA049_3023 ENOG4105CPC Aldo Keto reductase VAA049_3025 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VAA049_3026 ENOG4105CRK lysyL-tRNA synthetase VAA049_3027 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) VAA049_3028 ENOG4105CWM branched-chain amino acid transport system II carrier protein VAA049_3029 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) VAA049_303 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) VAA049_3030 ENOG4105C1J atp-dependent rna helicase VAA049_3031 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) VAA049_3033 ENOG4105BZU Histidine kinase VAA049_3035 ENOG4108YYD acetyltransferase VAA049_3036 ENOG4105XPQ lipid carrier protein VAA049_3037 ENOG4105BZU Histidine kinase VAA049_3038 ENOG4105CFP Peptidase U32 VAA049_3039 ENOG4106RZ4 Peptidase U32 VAA049_304 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity VAA049_3043 ENOG4105RT1 May be involved in cell division (By similarity) VAA049_3044 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) VAA049_3045 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) VAA049_3046 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) VAA049_3047 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) VAA049_3048 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) VAA049_3049 ENOG4105CHV Transcription elongation factor NusA VAA049_305 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) VAA049_3050 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) VAA049_3055 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) VAA049_3056 ENOG4105EEI dihydropteroate synthase VAA049_3057 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) VAA049_3058 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) VAA049_3059 ENOG4105HBR Rna-binding protein VAA049_306 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) VAA049_3060 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) VAA049_3061 ENOG4105FCK Membrane VAA049_3062 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase VAA049_3063 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) VAA049_3064 ENOG4105DR5 peptidase VAA049_3067 ENOG4108YX9 iron--sulfur cluster insertion protein erpA VAA049_3068 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase VAA049_307 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) VAA049_3070 ENOG4105IPI Membrane VAA049_3071 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) VAA049_3072 ENOG4105BZU Histidine kinase VAA049_3073 ENOG4107QRA Extracellular solute-binding protein, family 5 VAA049_3075 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VAA049_3076 ENOG4105C3U ABC transporter VAA049_3077 ENOG4108JQ7 (ABC) transporter VAA049_3079 ENOG4105RD7 BadF BadG BcrA BcrD VAA049_308 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) VAA049_3080 ENOG4105E2D ec 3.2.1.52 VAA049_3081 ENOG4105E2V Glycosyltransferase 36 VAA049_3083 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) VAA049_3087 ENOG4108YZA Nitrogen regulatory protein pii VAA049_3088 ENOG4105XTV UPF0231 protein VAA049_3089 ENOG4107QIJ Aconitate hydratase 2 VAA049_309 ENOG41083MP 50s ribosomal protein l29 VAA049_3091 ENOG4105D78 K07001 NTE family protein VAA049_3092 ENOG4105BZ4 penicillin-binding protein VAA049_3093 ENOG4105CQ7 ATP-dependent helicase VAA049_3095 ENOG4105PW4 Sugar fermentation stimulation protein homolog VAA049_3096 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters VAA049_3097 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) VAA049_3098 ENOG4105DJ0 Poly(A) Polymerase VAA049_3099 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase VAA049_31 ENOG4105C1A potassium transporter peripheral membrane VAA049_310 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal VAA049_3100 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) VAA049_3101 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) VAA049_3102 ENOG4105E3A (ABC) transporter VAA049_3103 ENOG4105DA5 (ABC) transporter VAA049_3104 ENOG4105CHH sulfate transporter VAA049_3105 ENOG41077A9 carbonic anhydrase VAA049_3106 ENOG4108UGV hypoxanthine phosphoribosyltransferase VAA049_3107 ENOG410630P Transcriptional regulator VAA049_3108 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) VAA049_3109 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) VAA049_311 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) VAA049_3110 ENOG41082RQ UPF0102 protein VAA049_3111 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) VAA049_3112 ENOG4105W4M Transport-associated protein VAA049_3113 ENOG4105KB2 stringent starvation protein b VAA049_3114 ENOG4107MKT Stringent starvation protein a VAA049_3115 ENOG4105EIX cytochrome c1 VAA049_3116 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) VAA049_3117 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) VAA049_3118 ENOG4108UJD 30S ribosomal protein S9 VAA049_3119 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) VAA049_312 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) VAA049_3120 ENOG4105D6Z AFG1 family ATPase VAA049_3122 ENOG4105C0H protease VAA049_3123 ENOG4105C0H protease VAA049_3124 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) VAA049_3125 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) VAA049_3126 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) VAA049_3127 ENOG4105K5M 30s ribosomal protein S16 VAA049_3128 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY VAA049_313 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits VAA049_3130 ENOG4106KVJ cytochrome C assembly protein VAA049_3131 ENOG4108JU6 CBS domain protein VAA049_3132 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) VAA049_3133 ENOG4105D9M gamma-glutamylcysteine synthetase VAA049_3135 ENOG4105W39 Membrane VAA049_3137 ENOG4105D9Q decarboxylase (Beta subunit) VAA049_3138 ENOG4107QSA Oxaloacetate decarboxylase VAA049_314 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) VAA049_3148 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) VAA049_3149 ENOG4105CFH Aspartokinase VAA049_315 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) VAA049_3150 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) VAA049_3151 ENOG4105Y3E Modulates RecA activity (By similarity) VAA049_3152 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) VAA049_3154 ENOG4108IJ6 ABC transporter VAA049_3155 ENOG4105ECW sulfate abc transporter VAA049_3156 ENOG4108I5D sulfate abc transporter VAA049_3157 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein VAA049_3158 ENOG4105C6T cysteine synthase VAA049_3159 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) VAA049_316 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) VAA049_3160 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VAA049_3161 ENOG4108K5P (LipO)protein VAA049_3162 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) VAA049_3163 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) VAA049_3164 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) VAA049_3165 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) VAA049_3166 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) VAA049_3168 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) VAA049_3169 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase VAA049_317 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) VAA049_3170 ENOG4107ZVW dihydroneopterin aldolase VAA049_3171 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) VAA049_3173 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) VAA049_3174 ENOG4105VCC 30S ribosomal protein S21 VAA049_3175 ENOG4105KTH gatB Yqey VAA049_3176 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) VAA049_3177 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VAA049_318 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) VAA049_3180 ENOG4105CH5 extracellular solute-binding protein, family 7 VAA049_3181 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) VAA049_3182 ENOG410804X Transcriptional regulator VAA049_3183 ENOG4105CA9 Pyruvate kinase VAA049_3185 ENOG4105MPN Membrane VAA049_3186 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) VAA049_3187 ENOG4108ZUB Lysine exporter protein (Lyse ygga) VAA049_3188 ENOG4105D64 Mechanosensitive ion channel VAA049_3189 ENOG4105D2N Aldolase VAA049_319 ENOG4105VPB 50S ribosomal protein L30 VAA049_3190 ENOG4105BZA Phosphoglycerate kinase VAA049_3191 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase VAA049_3192 ENOG4105D05 Receptor VAA049_3193 ENOG4108R4R Iron-regulated virulence regulatory protein VAA049_3194 ENOG4105CV1 Transketolase (EC 2.2.1.1) VAA049_3195 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP VAA049_3196 ENOG4105GPY SprT protein VAA049_3197 ENOG4105RWS endonuclease I VAA049_3198 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) VAA049_3199 ENOG4105D7Z glutathione synthase VAA049_32 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B VAA049_320 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) VAA049_3200 ENOG4108UJU UPF0301 protein VAA049_3201 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) VAA049_3202 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) VAA049_3204 ENOG4105CZX twitching motility protein VAA049_3205 ENOG4105CZX twitching motility protein VAA049_3206 ENOG4105DFA alanine racemase domain protein VAA049_3207 ENOG4105II7 pyrroline-5-carboxylate reductase VAA049_3208 ENOG4108VIA integral membrane protein VAA049_321 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) VAA049_3211 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) VAA049_3212 ENOG4105CSA Coproporphyrinogen iii oxidase VAA049_3213 ENOG4105CSV Glutaminase VAA049_3214 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) VAA049_3215 ENOG4105CEN a g-specific adenine glycosylase VAA049_3216 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) VAA049_3217 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division VAA049_3228 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) VAA049_3229 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) VAA049_323 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits VAA049_3230 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) VAA049_3231 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) VAA049_3232 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) VAA049_3233 ENOG4105NWN ApaG protein VAA049_3234 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) VAA049_3236 ENOG4107XM3 UPF0442 protein VAA049_3237 ENOG4105DWK Membrane VAA049_3238 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control VAA049_3239 ENOG4105K46 50S ribosomal protein l27 VAA049_324 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) VAA049_3240 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) VAA049_3241 ENOG4105EAH synthase VAA049_3242 ENOG4105D5Q Arginine ornithine antiporter VAA049_3243 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) VAA049_3244 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) VAA049_3247 ENOG41081QV Universal stress protein VAA049_325 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) VAA049_3252 ENOG4105CEU Arginine dihydrolase VAA049_3253 ENOG4105D1U peptidase U62 modulator of DNA gyrase VAA049_3255 ENOG4105QD6 exported protein VAA049_3256 ENOG4105C03 ribonuclease VAA049_3257 ENOG4108Z03 MAF-like protein VAA049_3258 ENOG4105VQ7 Rod shape-determining protein MreD VAA049_3259 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) VAA049_326 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) VAA049_3260 ENOG4105DFF Rod shape-determining protein mreb VAA049_3267 ENOG4105X0D Fimbrial protein VAA049_3269 ENOG4105D7Q type ii secretion system VAA049_327 ENOG4108ZT0 50S ribosomal protein l17 VAA049_3274 ENOG4105E4G Type IV pilus VAA049_3278 ENOG41062P1 Diguanylate cyclase phosphodiesterase VAA049_3279 ENOG4108UUM single-stranded DNA-binding protein VAA049_3280 ENOG41086KC Transcriptional regulator VAA049_3281 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase VAA049_3282 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) VAA049_3284 ENOG4105C5R Aminotransferase VAA049_3285 ENOG4105CFH Aspartokinase VAA049_3286 ENOG4105C3R Methionine synthase VAA049_3287 ENOG4105EEQ Na H antiporter VAA049_329 ENOG4108V1T peptidylprolyl cis-trans isomerase VAA049_33 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) VAA049_330 ENOG4108SXK Transporter Drug Metabolite Exporter family VAA049_3301 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) VAA049_3302 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) VAA049_3303 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) VAA049_3306 ENOG4105P4Z Phage shock protein G VAA049_3307 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) VAA049_3308 ENOG4105MYN Zinc uptake regulation protein VAA049_331 ENOG4108UBT opacity-associated protein VAA049_3311 ENOG4107QP8 phosphohexose isomerase VAA049_3312 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme VAA049_3313 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) VAA049_3314 ENOG4105CDU Replicative dna helicase VAA049_3316 ENOG4105K9Q Binds to the 23S rRNA (By similarity) VAA049_3317 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) VAA049_3318 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) VAA049_3319 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) VAA049_332 ENOG4107YB6 acetyltransferase, (GNAT) family VAA049_3320 ENOG4108UQY Iron-storage protein VAA049_3321 ENOG4105W53 bacterioferritin-associated ferredoxin VAA049_3322 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) VAA049_3323 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) VAA049_3324 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) VAA049_3325 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) VAA049_3327 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) VAA049_3328 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) VAA049_3329 ENOG4105WWK YheO domain protein VAA049_333 ENOG4105C1J atp-dependent rna helicase VAA049_3330 ENOG4108V1T peptidylprolyl cis-trans isomerase VAA049_3332 ENOG41069P5 Protein slyX homolog VAA049_3334 ENOG4105EPW hflc protein VAA049_3335 ENOG4107QJR hflk protein VAA049_3336 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) VAA049_3337 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) VAA049_3338 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) VAA049_3339 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) VAA049_3340 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase VAA049_3341 ENOG4105K8N protein family UPF0079, ATPase VAA049_3342 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) VAA049_335 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic VAA049_3352 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) VAA049_3353 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) VAA049_3354 ENOG4105DJ4 phosphatidylserine decarboxylase VAA049_3355 ENOG4105C8P )-transporter VAA049_3357 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) VAA049_3359 ENOG41063SB peptidase VAA049_336 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) VAA049_3360 ENOG41062JF Transcriptional regulator VAA049_3361 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) VAA049_3362 ENOG4105E09 nadh pyrophosphatase VAA049_3363 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor VAA049_3364 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) VAA049_3365 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) VAA049_3366 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) VAA049_3367 ENOG4108VZM 50s ribosomal protein L10 VAA049_3368 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) VAA049_3369 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) VAA049_337 ENOG4105C11 sulfate adenylyltransferase), subunit 2 VAA049_3370 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) VAA049_3371 ENOG4105PM1 preprotein translocase subunit SecE VAA049_3372 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) VAA049_3377 ENOG4105CS9 pantothenic acid kinase VAA049_3378 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase VAA049_3379 ENOG4105D4A Cell wall formation (By similarity) VAA049_338 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) VAA049_3381 ENOG4105JIM Phosphatidylserine synthase VAA049_3388 ENOG4107QK7 reductase VAA049_339 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) VAA049_3390 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) VAA049_3392 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) VAA049_3393 ENOG4105K63 Thioredoxin VAA049_3394 ENOG4105C1J atp-dependent rna helicase VAA049_3395 ENOG4105C9X ppx gppa phosphatase VAA049_3396 ENOG4105BZU Histidine kinase VAA049_3397 ENOG4105D8G Major Facilitator superfamily VAA049_34 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) VAA049_3400 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) VAA049_3401 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) VAA049_3402 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein VAA049_3403 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase VAA049_3404 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) VAA049_3405 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) VAA049_3406 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) VAA049_3407 ENOG4107R3N Filamentation induced by cAMP protein fic VAA049_3408 ENOG4105DIQ Transcriptional regulator VAA049_3409 ENOG4105C01 Dihydroxy-acid dehydratase VAA049_3410 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family VAA049_3411 ENOG4105C6Z Gluconate VAA049_3412 ENOG4108UHU Aldolase VAA049_3413 ENOG4105E0K tonB-dependent siderophore receptor VAA049_3415 ENOG4105C8Q Methyl-accepting chemotaxis VAA049_3416 ENOG4105CXN decarboxylase VAA049_3417 ENOG4105D5Q Arginine ornithine antiporter VAA049_3418 ENOG4108M3R transcriptional activator CadC VAA049_3419 ENOG4105W1Y Transcriptional regulator VAA049_3420 ENOG4105DC1 bifunctional purine biosynthesis protein purh VAA049_3421 ENOG4105C12 Phosphoribosylglycinamide synthetase VAA049_3423 ENOG4105K70 DNA-binding protein VAA049_3425 ENOG4105DKQ ROK family VAA049_3426 ENOG4105EIP mannose-6-phosphate isomerase VAA049_3427 ENOG4105R2J Conserved Protein VAA049_3428 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase VAA049_3429 ENOG4108RG0 uracil-dna glycosylase VAA049_343 ENOG4105C19 ABC transporter VAA049_3430 ENOG4105CUY Mechanosensitive ion channel VAA049_3433 ENOG4105CY0 Metallo-Beta-Lactamase VAA049_3434 ENOG4105D3Q Sugar transferase VAA049_3439 ENOG4107TXM Nad-dependent epimerase dehydratase VAA049_3440 ENOG4105C0K Gdp-mannose 4,6-dehydratase VAA049_3442 ENOG4105CKK Glycosyl transferase, family 2 VAA049_3445 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase VAA049_3446 ENOG4105CEY Amp-dependent synthetase and ligase VAA049_3447 ENOG4105CHR reductase VAA049_3449 ENOG4105CHR reductase VAA049_3451 ENOG4108P1X synthase VAA049_3453 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) VAA049_3454 ENOG4105C1B dTDP-glucose 4-6-dehydratase VAA049_3456 ENOG4108TJN glycosyl transferase group 1 VAA049_3458 ENOG4105EY8 ABC transporter VAA049_346 ENOG4108UUE Transcriptional regulator VAA049_3460 ENOG4107QKV phosphomannomutase VAA049_3461 ENOG4105CJT Mannose-1-phosphate guanylyltransferase VAA049_3462 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) VAA049_3463 ENOG4107T94 Endo-14-beta-xylanase VAA049_3466 ENOG4105XA0 heptosyltransferase ii VAA049_3468 ENOG4108ST3 glycosyltransferase VAA049_3469 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase VAA049_347 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) VAA049_3475 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) VAA049_3476 ENOG4105DKP glycosyl transferase, family 9 VAA049_3477 ENOG4106WTF Glycosyl transferase, family 2 VAA049_3478 ENOG4105M5K heptosyltransferase VAA049_3479 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) VAA049_348 ENOG4105CFU surface antigen VAA049_3480 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) VAA049_3482 ENOG4105W0E 50S ribosomal protein L33 VAA049_3483 ENOG4105KDC 50s ribosomal protein l28 VAA049_3485 ENOG4105C8Q Methyl-accepting chemotaxis VAA049_3486 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase VAA049_3487 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) VAA049_3488 ENOG4105D1S lipid A biosynthesis VAA049_3489 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase VAA049_3490 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) VAA049_3491 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) VAA049_3492 ENOG4105DSJ YicC domain protein VAA049_3494 ENOG4105C5Y PTS System VAA049_3495 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate VAA049_3496 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) VAA049_3497 ENOG4105S6R Iron-hydroxamate transporter permease subunit VAA049_3498 ENOG4105J76 Periplasmic binding protein VAA049_3499 ENOG4105E0A ABC, transporter VAA049_35 ENOG4108WZM domain protein VAA049_350 ENOG41066HZ AIG2-like family VAA049_3500 ENOG4105E0K tonB-dependent siderophore receptor VAA049_3501 ENOG4105BZ1 (ABC) transporter VAA049_3504 ENOG4105C9U ATP-dependent DNA helicase RecQ VAA049_3505 ENOG4105FR1 rard protein VAA049_3506 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) VAA049_3507 ENOG4108DMH HTH_ARAC VAA049_3509 ENOG4105C4R Atp-dependent dna helicase VAA049_351 ENOG4105F0N pyrophosphate phospho-hydrolase VAA049_3510 ENOG4105DGW oligopeptidase A VAA049_3511 ENOG4105D6S protein involved in catabolism of external DNA VAA049_3512 ENOG4105DC8 reductase VAA049_3514 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VAA049_3515 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component VAA049_3516 ENOG4105DEF Extracellular solute-binding protein, family 5 VAA049_352 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 VAA049_3523 ENOG4105MPD Cytochrome VAA049_3524 ENOG4105C4R Atp-dependent dna helicase VAA049_3525 ENOG4105Y7M Transcriptional regulator, TetR family VAA049_3526 ENOG410624X efflux transporter, rnd family, mfp subunit VAA049_3527 ENOG4105BZS acriflavin resistance protein VAA049_3528 ENOG4105W0Z cytoplasmic protein VAA049_3529 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase VAA049_353 ENOG4105DFU Cell wall formation (By similarity) VAA049_3530 ENOG4105EMY transcriptional regulator VAA049_354 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase VAA049_3544 ENOG4108RR8 protoporphyrinogen oxidase VAA049_3545 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) VAA049_3546 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein VAA049_3547 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase VAA049_3548 ENOG4105CHU acetyl-coa acetyltransferase VAA049_3549 ENOG4105F52 Transcriptional regulator VAA049_355 ENOG4105DP9 ABC transporter VAA049_3550 ENOG4105CZQ inner membrane transport protein YdhC VAA049_3552 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) VAA049_3553 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) VAA049_3554 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) VAA049_3555 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) VAA049_3556 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) VAA049_3557 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) VAA049_3558 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) VAA049_3559 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) VAA049_356 ENOG4106SMU thiamine transporter membrane protein VAA049_3560 ENOG410684E atp synthase VAA049_3561 ENOG4105FA0 parb-like partition protein VAA049_3562 ENOG4107QJE Chromosome Partitioning Protein VAA049_3563 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) VAA049_3564 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) VAA049_3565 ENOG4105QTB Flavodoxin VAA049_3566 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) VAA049_3567 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins VAA049_3568 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) VAA049_357 ENOG4107T0D ABC, transporter VAA049_3570 ENOG4105E5Q amino acid AbC transporter VAA049_3571 ENOG4105EAB amino acid AbC transporter VAA049_358 ENOG4105N42 UPF0307 protein VAA049_359 ENOG4105CMS peptidase U62, modulator of DNA gyrase VAA049_36 ENOG4105C79 DNA protecting protein DprA VAA049_360 ENOG4105CJW magnesium transporter VAA049_361 ENOG41080Z8 PHOSPHOCARRIER protein VAA049_363 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN VAA049_364 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA VAA049_365 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VAA049_366 ENOG4108IUZ ABC transporter VAA049_367 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA VAA049_369 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase VAA049_37 ENOG4108RPN Protein smg homolog VAA049_370 ENOG4105C2X Arabinose 5-phosphate isomerase VAA049_372 ENOG4105DHJ ABC, transporter VAA049_373 ENOG4105CY3 ABC transporter, permease VAA049_374 ENOG4107PE3 Mammalian cell entry related domain protein VAA049_375 ENOG4105E3I toluene tolerance VAA049_377 ENOG4105VFK BolA family VAA049_378 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) VAA049_379 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase VAA049_38 ENOG4108WI1 Dna topoisomerase VAA049_380 ENOG4105KME endoribonuclease L-psp VAA049_381 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) VAA049_382 ENOG4105CXT aspartate transcarbamylase VAA049_383 ENOG4105DBV ornithine carbamoyltransferase VAA049_384 ENOG4108IAB Phoh family VAA049_385 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) VAA049_386 ENOG4105D3G Pseudouridine synthase VAA049_387 ENOG4105C5I Dehydrogenase VAA049_388 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) VAA049_389 ENOG4105MYG DNA polymerase iii, chi subunit VAA049_39 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit VAA049_390 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) VAA049_391 ENOG4108M8S permease YjgP YjgQ family protein VAA049_392 ENOG4108K5H permease YjgP YjgQ family protein VAA049_395 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase VAA049_4 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) VAA049_40 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) VAA049_405 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) VAA049_406 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) VAA049_407 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) VAA049_408 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) VAA049_41 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) VAA049_412 ENOG41064T2 transcriptional regulator, lysR family VAA049_413 ENOG4108IQE Amp-dependent synthetase and ligase VAA049_414 ENOG4105C7K acetolactate synthase VAA049_415 ENOG4108ZP8 Acetolactate synthase small subunit VAA049_416 ENOG4108JQ1 Dehydrogenase VAA049_417 ENOG4105E66 phosphoriboisomerase A VAA049_418 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase VAA049_419 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) VAA049_42 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) VAA049_421 ENOG4105D0A hydroxylase VAA049_422 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family VAA049_424 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) VAA049_425 ENOG4105Y75 tpr repeat protein VAA049_427 ENOG4108IYU L-aspartate oxidase VAA049_428 ENOG4105EMN RNA polymerase sigma factor VAA049_43 ENOG4105E2X shikimate dehydrogenase VAA049_430 ENOG4105VQK sigma E regulatory protein, MucB RseB VAA049_431 ENOG4105WMJ Positive regulator of sigma E, RseC MucC VAA049_432 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) VAA049_433 ENOG4105C3F Signal peptidase i VAA049_434 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) VAA049_435 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) VAA049_436 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) VAA049_437 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) VAA049_438 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) VAA049_44 ENOG4108Z0R Transferase VAA049_441 ENOG4105BZU Histidine kinase VAA049_443 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) VAA049_444 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) VAA049_445 ENOG4105DXN mazG family VAA049_446 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) VAA049_447 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) VAA049_448 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate VAA049_451 ENOG4106MWK domain protein VAA049_452 ENOG4105CJ3 phosphate transporter VAA049_453 ENOG4107IX6 phosphate transport regulator VAA049_454 ENOG4105I7R Adenylate cyclase VAA049_456 ENOG4105C8Q Methyl-accepting chemotaxis VAA049_457 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) VAA049_458 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) VAA049_459 ENOG4105DFG type I secretion outer membrane protein VAA049_460 ENOG41087AY ADP-Ribose pyrophosphatase VAA049_461 ENOG4108SX3 cytoplasmic protein VAA049_462 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) VAA049_463 ENOG4105IPS esterase VAA049_464 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) VAA049_465 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) VAA049_466 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) VAA049_467 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) VAA049_468 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) VAA049_469 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) VAA049_470 ENOG4105D7Q type ii secretion system VAA049_471 ENOG4107QHF type ii secretion system protein e VAA049_472 ENOG4105X0D Fimbrial protein VAA049_473 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase VAA049_475 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) VAA049_476 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) VAA049_477 ENOG4105T95 Thiol disulfide interChange protein VAA049_478 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) VAA049_479 ENOG4105CGH 5'-nucleotidase VAA049_480 ENOG41073TP transcriptional regulator VAA049_481 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) VAA049_482 ENOG4107QSN dihydrolipoamide acetyltransferase VAA049_483 ENOG4107QN2 dihydrolipoyl dehydrogenase VAA049_484 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) VAA049_485 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) VAA049_486 ENOG4105CJN penicillin-binding protein VAA049_487 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) VAA049_488 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) VAA049_489 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) VAA049_490 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) VAA049_492 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) VAA049_493 ENOG4105DFU Cell wall formation (By similarity) VAA049_494 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) VAA049_495 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) VAA049_496 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) VAA049_497 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) VAA049_499 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving VAA049_500 ENOG4105M6F mutator MutT protein VAA049_501 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) VAA049_502 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain VAA049_503 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain VAA049_507 ENOG4105VP0 transcriptional regulator, lysR family VAA049_508 ENOG4105EJ9 Membrane VAA049_509 ENOG4105EN6 Membrane VAA049_510 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) VAA049_512 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) VAA049_514 ENOG4105BZ8 glutamate synthase VAA049_515 ENOG4105CBC glutamate synthase VAA049_518 ENOG4105N5T Radical SAM Protein VAA049_52 ENOG4105WMR Protein CrcB homolog VAA049_520 ENOG4105BZU Histidine kinase VAA049_521 ENOG41065U4 response regulator VAA049_524 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) VAA049_526 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) VAA049_527 ENOG4105D98 threonine synthase VAA049_528 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) VAA049_529 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) VAA049_53 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) VAA049_530 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) VAA049_533 ENOG4105BZG amino acid carrier protein VAA049_536 ENOG4105EYA deoxyribonuclease VAA049_537 ENOG4105D9N nucleoside VAA049_538 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) VAA049_539 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) VAA049_540 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) VAA049_541 ENOG4105D3A purine nucleoside phosphorylase DeoD-type VAA049_543 ENOG4105EAC phosphoserine phosphatase VAA049_545 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) VAA049_546 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) VAA049_547 ENOG4108IQE Amp-dependent synthetase and ligase VAA049_548 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase VAA049_55 ENOG4105D06 uba thif-type nad fad binding protein VAA049_550 ENOG4105CNT hydrolase family 2 VAA049_551 ENOG41060NJ transcriptional regulator VAA049_553 ENOG4108Y51 tRNA-binding protein VAA049_555 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) VAA049_557 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) VAA049_559 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) VAA049_56 ENOG4105WHD thiamine biosynthesis protein ThiS VAA049_560 ENOG4105X2V dna damage-inducible protein VAA049_563 ENOG4105DSY exodeoxyribonuclease V, gamma VAA049_565 ENOG4107QKA exodeoxyribonuclease V beta VAA049_566 ENOG4107QYX exodeoxyribonuclease v alpha VAA049_568 ENOG4107QZM n-acetylglutamate synthase VAA049_57 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) VAA049_570 ENOG4105CA3 membrane-bound lytic murein transglycosylase VAA049_571 ENOG4105CUZ uba thif-type nad fad binding protein VAA049_572 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) VAA049_573 ENOG4105C9B Cysteine desulfurase VAA049_574 ENOG4107S0N DJ-1 family VAA049_575 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) VAA049_576 ENOG4105DRB nucleoside-specific channel-forming protein VAA049_578 ENOG4105K6V RNA polymerase VAA049_58 ENOG4105D41 biosynthesis protein thiH VAA049_580 ENOG4105EYM Major Facilitator superfamily VAA049_581 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) VAA049_583 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) VAA049_584 ENOG4105M85 Bola protein VAA049_585 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) VAA049_586 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) VAA049_587 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) VAA049_588 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) VAA049_589 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) VAA049_59 ENOG4105DC7 peptidase M24 VAA049_59 ENOG4105DC7 peptidase M24 VAA049_590 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) VAA049_591 ENOG4105CJ2 (LipO)protein VAA049_593 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) VAA049_595 ENOG4105BZU Histidine kinase VAA049_596 ENOG4105C8J )-transporter VAA049_598 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) VAA049_599 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) VAA049_600 ENOG4105CIN aminoacyl-histidine dipeptidase VAA049_601 ENOG4105C7N Xanthine uracil vitamin C permease VAA049_602 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) VAA049_604 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) VAA049_605 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) VAA049_606 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) VAA049_607 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) VAA049_608 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) VAA049_61 ENOG4105CNH Multidrug resistance protein MdtL VAA049_611 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) VAA049_612 ENOG4107YIM Involved in the transcription termination process (By similarity) VAA049_613 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) VAA049_614 ENOG4108ZAI phosphatidylglycerophosphatase a VAA049_615 ENOG4108T8E UPF0325 protein VAA049_616 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) VAA049_617 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) VAA049_618 ENOG4105CE9 30S ribosomal protein S2 VAA049_619 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) VAA049_620 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) VAA049_621 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) VAA049_622 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) VAA049_623 ENOG4105KNE Phosphatidate cytidylyltransferase VAA049_624 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) VAA049_625 ENOG4105DZP Membrane-associated zinc metalloprotease VAA049_627 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) VAA049_628 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) VAA049_629 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) VAA049_63 ENOG4108VVK transcriptional Regulator, AsnC VAA049_630 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) VAA049_631 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) VAA049_632 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) VAA049_633 ENOG4105C0B DNA polymerase III (alpha subunit) VAA049_634 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) VAA049_635 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) VAA049_636 ENOG4105N7H Cytochrome VAA049_637 ENOG4105PY6 Phenolic acid decarboxylase VAA049_638 ENOG4108YZA Nitrogen regulatory protein pii VAA049_64 ENOG4105BZU Histidine kinase VAA049_640 ENOG4105E9H Lytic Murein transglycosylase VAA049_641 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) VAA049_642 ENOG4105D1A Methyltransferase VAA049_643 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) VAA049_644 ENOG4108JDX DNA polymerase iii, epsilon subunit VAA049_646 ENOG4107QPN acyl-Coa dehydrogenase VAA049_647 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) VAA049_648 ENOG4105E7A Glutamine amidotransferase VAA049_649 ENOG4108V3E phosphoribosylglycinamide formyltransferase VAA049_65 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) VAA049_650 ENOG4105CXB phosphoribosylaminoimidazole synthetase VAA049_651 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) VAA049_652 ENOG4105BZU Histidine kinase VAA049_653 ENOG4105FE9 pseudouridine synthase VAA049_654 ENOG4108DG9 Smr protein MutS2 VAA049_659 ENOG4105E2D ec 3.2.1.52 VAA049_661 ENOG4105C59 p-type ATPase VAA049_662 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) VAA049_663 ENOG4105UYK outer membrane protein a VAA049_665 ENOG4107RBR Receptor VAA049_666 ENOG4105Q26 Siderophore-interacting protein VAA049_667 ENOG4105C0W non-ribosomal peptide synthetase VAA049_67 ENOG4105EMK carboxylate amino acid amine transporter VAA049_674 ENOG4107R88 Chemotaxis protein (CheV) VAA049_675 ENOG4105BZU Histidine kinase VAA049_676 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) VAA049_677 ENOG4108ZC9 flagellar basal-body rod protein flgc VAA049_678 ENOG4105W00 Flagellar hook capping protein VAA049_679 ENOG4105BZE flagellar hook protein, FlgE VAA049_68 ENOG4108M6U Universal stress protein A VAA049_680 ENOG4108KPB Flagellar basal-body rod protein FlgF VAA049_681 ENOG4105CGA flagellar basal-body rod protein FlgG VAA049_682 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) VAA049_683 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) VAA049_684 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj VAA049_687 ENOG4105I03 Flagellin VAA049_688 ENOG4105I03 Flagellin VAA049_69 ENOG41090A1 ferritin VAA049_7 ENOG4108ZNX Heat shock protein VAA049_70 ENOG4108V6B universal stress protein B VAA049_707 ENOG4105C3G gtp-binding protein VAA049_708 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) VAA049_709 ENOG4105C5T Phosphoribosyl pyrophosphate synthase VAA049_710 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) VAA049_711 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) VAA049_712 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) VAA049_713 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) VAA049_714 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) VAA049_715 ENOG4108YY7 Invasion gene expression up-regulator SirB VAA049_716 ENOG41063JG Transcriptional regulator VAA049_717 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase VAA049_718 ENOG4105CGH 5'-nucleotidase VAA049_719 ENOG4108Z66 YbaK ebsC protein VAA049_72 ENOG4105CBX hi0933 family VAA049_720 ENOG4105C2W permease VAA049_723 ENOG4105CS1 NAD(P)H quinone oxidoreductase VAA049_724 ENOG4105K89 arsenate reductase VAA049_725 ENOG4105ERG peptidase m48, ste24p VAA049_728 ENOG4105C8Q Methyl-accepting chemotaxis VAA049_729 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen VAA049_73 ENOG4105CGY Dna recombination protein VAA049_731 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) VAA049_732 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) VAA049_735 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) VAA049_736 ENOG4105KUZ arsenate reductase VAA049_739 ENOG4105QZU Inner membrane protein YfeZ VAA049_74 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) VAA049_740 ENOG4105EZR dyp-type peroxidase family protein VAA049_741 ENOG4105I03 Flagellin VAA049_742 ENOG4105I03 Flagellin VAA049_743 ENOG4105I03 Flagellin VAA049_744 ENOG41063QE flagellar protein FlaG VAA049_745 ENOG4107W9T flagellar hook-associated VAA049_747 ENOG4105MQ3 flagellar protein FliS VAA049_748 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VAA049_749 ENOG4105BZU Histidine kinase VAA049_75 ENOG4105JC1 sterol-binding domain protein VAA049_750 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VAA049_751 ENOG4105VQ0 flagellar hook-basal body complex protein fliE VAA049_752 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) VAA049_753 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) VAA049_754 ENOG4105W2B Flagellar assembly protein VAA049_755 ENOG4108JIR Flagellum-specific ATP synthase VAA049_758 ENOG4105X6C Flagellar basal body-associated protein FliL VAA049_759 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) VAA049_76 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) VAA049_760 ENOG4105DD5 Flagellar motor switch protein VAA049_761 ENOG4105VTB flagellar biosynthesis protein fliO VAA049_762 ENOG4105CN7 Flagellar biosynthetic protein FliP VAA049_763 ENOG4105VS8 Flagellar biosynthetic protein fliq VAA049_764 ENOG4105D19 Role in flagellar biosynthesis (By similarity) VAA049_765 ENOG4105D00 flagellar biosynthetic protein flhB VAA049_767 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) VAA049_768 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase VAA049_769 ENOG4105EN6 Membrane VAA049_77 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) VAA049_770 ENOG4108BPE -transporting atpase VAA049_771 ENOG4105MH2 YfcL protein VAA049_772 ENOG4105Q8W reductase VAA049_773 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) VAA049_774 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) VAA049_775 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) VAA049_776 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) VAA049_777 ENOG41090R7 Ferric uptake VAA049_779 ENOG4105CMU LysR family (Transcriptional regulator VAA049_78 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) VAA049_780 ENOG4105VAW lrga family VAA049_781 ENOG41067MG lrgb family VAA049_782 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) VAA049_784 ENOG4105EV9 Alpha Beta Hydrolase VAA049_785 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) VAA049_786 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 VAA049_788 ENOG4107QNR UPF0135 protein VAA049_789 ENOG4105BZN citrate synthase VAA049_79 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) VAA049_790 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit VAA049_791 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein VAA049_792 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) VAA049_793 ENOG4105E33 succinate dehydrogenase VAA049_794 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 VAA049_795 ENOG4105C7S Dehydrogenase VAA049_796 ENOG4105CMV Succinyl-CoA synthetase subunit beta VAA049_797 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha VAA049_798 ENOG4105FAV ABC, transporter VAA049_799 ENOG4105FDK ABC transporter VAA049_8 ENOG4105JKW Valine--pyruvate aminotransferase VAA049_80 ENOG4105CA0 peroxidase VAA049_800 ENOG4105NXV High-affinity zinc uptake system protein VAA049_801 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) VAA049_802 ENOG4105XFK Ferrous iron transport protein A VAA049_806 ENOG4105C75 arginyL-tRNA synthetase VAA049_807 ENOG4108JQM Insulinase (Peptidase family M16) VAA049_809 ENOG4108BY2 phosphohistidine phosphatase VAA049_81 ENOG4107R73 Mate efflux family protein VAA049_810 ENOG4105D7B Flagellar biosynthesis protein flha VAA049_811 ENOG4105FZW flagellar biosynthesis regulator FlhF VAA049_812 ENOG4107R21 site-determining protein VAA049_813 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VAA049_814 ENOG4108VYJ response regulator receiver protein VAA049_815 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) VAA049_816 ENOG4105CBS Chea signal transduction histidine kinase VAA049_817 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) VAA049_818 ENOG4107QJE Chromosome Partitioning Protein VAA049_820 ENOG4108V3W Chemotaxis protein, CheW VAA049_822 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) VAA049_823 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) VAA049_824 ENOG41060IM Heme exporter protein VAA049_825 ENOG41067VX Heme exporter protein VAA049_826 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) VAA049_827 ENOG4105DA4 cytochrome c-type biogenesis protein VAA049_828 ENOG4107QX9 Thiol disulfide interChange protein VAA049_829 ENOG4105KWW Biogenesis protein VAA049_83 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) VAA049_831 ENOG410903C (LipO)protein VAA049_834 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) VAA049_835 ENOG4105M2J Glutaredoxin VAA049_836 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) VAA049_837 ENOG4105DGU Histone deacetylase VAA049_84 ENOG4105E55 glycerol-3-phosphate acyltransferase VAA049_840 ENOG4105E68 Sulfatase VAA049_842 ENOG4106V8H Nucleoid-associated protein VAA049_844 ENOG4105DFD Na H antiporter VAA049_845 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) VAA049_846 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein VAA049_847 ENOG4108EKI Dehydrogenase VAA049_849 ENOG4105CHH sulfate transporter VAA049_85 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) VAA049_850 ENOG4105C03 ribonuclease VAA049_851 ENOG4105EI2 Pseudouridine synthase VAA049_852 ENOG4108UHJ MAF-like protein VAA049_853 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein VAA049_854 ENOG4105VGS 50s ribosomal protein l32 VAA049_855 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) VAA049_856 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) VAA049_857 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase VAA049_858 ENOG4105CHR reductase VAA049_859 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) VAA049_86 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) VAA049_860 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) VAA049_861 ENOG4105YAZ 4-amino-4-deoxychorismate lyase VAA049_862 ENOG4105HHA aminodeoxychorismate lyase VAA049_863 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) VAA049_864 ENOG4107QRG dna polymerase iii VAA049_865 ENOG4105F8V Hydrolase, tatD family VAA049_866 ENOG4105CI1 PTS System VAA049_868 ENOG4105C8J )-transporter VAA049_87 ENOG4105X6C Flagellar basal body-associated protein FliL VAA049_871 ENOG4108NRW Phospholipase, patatin family VAA049_872 ENOG4105CA9 Pyruvate kinase VAA049_873 ENOG4105DAG ROK family VAA049_874 ENOG4107R88 Chemotaxis protein (CheV) VAA049_877 ENOG4105DHI Methyltransferase VAA049_879 ENOG4105DSB aldose 1-epimerase VAA049_88 ENOG4105C8Q Methyl-accepting chemotaxis VAA049_880 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase VAA049_881 ENOG4105E0X reductase VAA049_883 ENOG4105VUT cytoplasmic protein VAA049_884 ENOG4105HDK L-asparaginase VAA049_885 ENOG4105D07 Signal peptide peptidase, SppA VAA049_886 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase VAA049_887 ENOG4105CIY formyltetrahydrofolate deformylase VAA049_889 ENOG4105DVT helicase VAA049_890 ENOG41072GX Peptidase M22 Glycoprotease VAA049_893 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) VAA049_896 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) VAA049_899 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein VAA049_9 ENOG4105C38 Glycyl-tRNA synthetase beta subunit VAA049_90 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) VAA049_901 ENOG4105DK2 UPF0207 protein VAA049_902 ENOG4105CHM Aminotransferase VAA049_903 ENOG4105E4F Isochorismate synthase VAA049_904 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) VAA049_905 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) VAA049_906 ENOG4108IPT Naphthoate synthase VAA049_907 ENOG4105DNI Converts SHCHC to OSB (By similarity) VAA049_908 ENOG4105CEY Amp-dependent synthetase and ligase VAA049_909 ENOG4105DKK Benzoate VAA049_91 ENOG4105F8V Hydrolase, tatD family VAA049_910 ENOG4108JCI Transcriptional regulator VAA049_911 ENOG4108N3W hemolysin secretion protein VAA049_918 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) VAA049_919 ENOG4107QMS site-determining protein VAA049_92 ENOG4105D52 delta-aminolevulinic acid dehydratase VAA049_920 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) VAA049_921 ENOG4105VNG YcgL domain-containing protein VAA049_922 ENOG4105CVE Lytic murein transglycosylase VAA049_923 ENOG4105JQN Transcriptional regulator VAA049_924 ENOG4105D9N nucleoside VAA049_926 ENOG4105CUW cytochrome C-TYPE protein VAA049_927 ENOG4107QY8 reductase VAA049_930 ENOG4105JQN Transcriptional regulator VAA049_933 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) VAA049_94 ENOG4105C2M dna polymerase I VAA049_941 ENOG4108HPI phosphatidate Cytidylyltransferase VAA049_943 ENOG4105BZU Histidine kinase VAA049_946 ENOG4105CNG UPF0061 protein VAA049_947 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit VAA049_948 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ VAA049_949 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VAA049_95 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) VAA049_950 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VAA049_952 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation VAA049_953 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) VAA049_954 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) VAA049_955 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) VAA049_956 ENOG4105K70 DNA-binding protein VAA049_957 ENOG4105EIN peptidylprolyl cis-trans isomerase VAA049_958 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein VAA049_959 ENOG4105CAT Cytidine monophosphate kinase VAA049_96 ENOG4106RE7 Cytochrome VAA049_960 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) VAA049_961 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) VAA049_962 ENOG4105Q4A inner membrane protein yciS VAA049_963 ENOG4105CFV Tetratricopeptide repeat protein VAA049_964 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) VAA049_965 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase VAA049_967 ENOG4107R11 Transcriptional regulator VAA049_969 ENOG4105DCF alanine dehydrogenase VAA049_970 ENOG4105EW9 transcriptional regulator AsnC family VAA049_971 ENOG4105CNU cell division protein FtsK VAA049_972 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) VAA049_973 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) VAA049_974 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) VAA049_976 ENOG4108NVR Methyl-accepting chemotaxis VAA049_977 ENOG4105K59 histidine triad (HIT) protein VAA049_98 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) VAA049_983 ENOG4105CEP NADH dehydrogenase VAA049_985 ENOG4106M3D hemolysin VAA049_987 ENOG4108JA2 transcriptioN-repair coupling factor VAA049_989 ENOG4105D60 lipoprotein releasing system transmembrane protein VAA049_99 ENOG4105XCT Protein of unknown function (DUF2489) VAA049_990 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) VAA049_991 ENOG4105D60 lipoprotein releasing system transmembrane protein VAA049_993 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 VAA049_994 ENOG4105BZ1 (ABC) transporter VAA049_995 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) VAA049_997 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) VAA049_998 ENOG4105ED1 spovr family VAA049_999 ENOG4106AKX UPF0229 protein