locus-tag	class	description
VAA049_1	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VAA049_10	COG0752	glycyl-tRNA synthetase alpha subunit
VAA049_100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VAA049_1000	COG2766	serine protein kinase
VAA049_1001	COG3013	Belongs to the UPF0304 family
VAA049_1003	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VAA049_1004	COG0840	transmembrane signaling receptor activity
VAA049_1006	COG1882	Formate acetyltransferase
VAA049_101	COG3071	HemY protein
VAA049_1011	COG4215	(ABC) transporter
VAA049_1012	COG4160	amino acid transport
VAA049_1013	COG0708	Exodeoxyribonuclease III
VAA049_1014	COG0840	transmembrane signaling receptor activity
VAA049_1016	COG3923	Primosomal replication protein n
VAA049_1017	COG0730	response to heat
VAA049_1018	COG1199	ATP-dependent helicase activity
VAA049_1019	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VAA049_102	COG2959	enzyme of heme biosynthesis
VAA049_1021	COG2801	Transposase and inactivated derivatives
VAA049_1023	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VAA049_1024	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VAA049_1025	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VAA049_1026	COG0215	cysteine-tRNA ligase activity
VAA049_1027	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VAA049_1028	COG0632	four-way junction helicase activity
VAA049_1029	COG2255	four-way junction helicase activity
VAA049_103	COG1587	Uroporphyrinogen-III synthase
VAA049_1030	COG1271	oxidase subunit
VAA049_1031	COG1294	oxidase, subunit
VAA049_1032	COG4890	Cyd operon protein YbgT
VAA049_1033	COG0824	Thioesterase
VAA049_1034	COG0811	peptide transport
VAA049_1037	COG0823	Involved in the tonB-independent uptake of proteins
VAA049_1038	COG2885	chlorophyll binding
VAA049_104	COG0181	hydroxymethylbilane synthase activity
VAA049_1040	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VAA049_1042	COG5002	protein histidine kinase activity
VAA049_1042	COG0784	Response regulator, receiver
VAA049_1044	COG1482	cell wall glycoprotein biosynthetic process
VAA049_1045	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VAA049_1045	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VAA049_1045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAA049_1047	COG2207	Transcriptional regulator
VAA049_1048	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VAA049_1049	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VAA049_105	COG3072	Adenylate cyclase
VAA049_1050	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VAA049_1051	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAA049_1051	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VAA049_1051	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VAA049_1052	COG1012	belongs to the aldehyde dehydrogenase family
VAA049_1053	COG3284	Transcriptional regulator
VAA049_1054	COG4628	conserved protein (DUF2132)
VAA049_1056	COG0415	Belongs to the DNA photolyase family
VAA049_106	COG1965	Belongs to the frataxin family
VAA049_1062	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAA049_1064	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VAA049_1064	COG3008	intermembrane lipid transfer
VAA049_1065	COG2995	paraquat-inducible protein a
VAA049_1066	COG1309	transcriptional regulator
VAA049_1068	COG1012	belongs to the aldehyde dehydrogenase family
VAA049_107	COG0019	diaminopimelate decarboxylase activity
VAA049_1071	COG1960	acyl-CoA dehydrogenase activity
VAA049_1072	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VAA049_1073	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VAA049_1074	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VAA049_1075	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VAA049_1076	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VAA049_1078	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VAA049_1079	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VAA049_108	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VAA049_1080	COG0297	glycogen (starch) synthase activity
VAA049_1084	COG3070	regulator of competence-specific genes
VAA049_1085	COG1609	Transcriptional regulator
VAA049_1087	COG0745	RESPONSE REGULATOR receiver
VAA049_1088	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VAA049_1089	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VAA049_1090	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
VAA049_1091	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VAA049_1092	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VAA049_1095	COG1032	radical SAM domain protein
VAA049_1096	COG5001	Diguanylate cyclase
VAA049_1097	COG0612	Peptidase, M16
VAA049_11	COG2119	membrane
VAA049_110	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VAA049_1100	COG0583	DNA-binding transcription factor activity
VAA049_1101	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VAA049_1103	COG2350	Protein conserved in bacteria
VAA049_1104	COG1607	acyl-coa hydrolase
VAA049_1105	COG2917	probably involved in intracellular septation
VAA049_1107	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VAA049_1108	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VAA049_111	COG1011	Hydrolase
VAA049_1110	COG2116	formate transmembrane transporter activity
VAA049_1111	COG4459	periplasmic nitrate reductase
VAA049_1112	COG3005	denitrification pathway
VAA049_1113	COG0243	molybdopterin cofactor binding
VAA049_1116	COG1227	inorganic diphosphatase activity
VAA049_1119	COG4172	Belongs to the ABC transporter superfamily
VAA049_112	COG3287	FIST C domain
VAA049_112	COG2200	EAL domain
VAA049_112	COG2199	diguanylate cyclase activity
VAA049_1121	COG4171	peptide transport system, permease
VAA049_1122	COG4168	peptide transport system, permease
VAA049_1124	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VAA049_1125	COG1842	Phage shock protein A
VAA049_1128	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAA049_1131	COG2818	Glycosylase
VAA049_1132	COG0626	cystathionine gamma-synthase activity
VAA049_1134	COG0733	neurotransmitter:sodium symporter activity
VAA049_1135	COG0564	pseudouridine synthase activity
VAA049_1136	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VAA049_1137	COG4136	ATPase activity
VAA049_1138	COG4135	transport system, permease component
VAA049_1139	COG4134	Bacterial extracellular solute-binding protein
VAA049_1141	COG3313	Fe-S protein
VAA049_1143	COG0842	Transport permease protein
VAA049_1144	COG1131	(ABC) transporter
VAA049_1145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAA049_1146	COG0814	amino acid
VAA049_1149	COG2239	Acts as a magnesium transporter
VAA049_115	COG0561	phosphatase activity
VAA049_1153	COG4934	collagen metabolic process
VAA049_116	COG2267	carboxylic ester hydrolase activity
VAA049_1161	COG0840	transmembrane signaling receptor activity
VAA049_1163	COG2203	Gaf domain
VAA049_1163	COG4251	negative regulation of phosphorylation
VAA049_1163	COG5001	Diguanylate cyclase
VAA049_1163	COG3706	GGDEF domain
VAA049_1164	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VAA049_1165	COG5002	protein histidine kinase activity
VAA049_1168	COG1061	Type III restriction enzyme res subunit
VAA049_1169	COG1187	pseudouridine synthase activity
VAA049_117	COG1280	lysine exporter protein (LysE YggA)
VAA049_1170	COG2814	Major facilitator Superfamily
VAA049_1172	COG0702	epimerase
VAA049_1173	COG0534	Mate efflux family protein
VAA049_1174	COG4181	ATPase activity
VAA049_1177	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VAA049_1179	COG1748	Saccharopine dehydrogenase
VAA049_118	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VAA049_1180	COG0019	diaminopimelate decarboxylase activity
VAA049_1182	COG1538	Outer membrane efflux protein
VAA049_1187	COG0583	DNA-binding transcription factor activity
VAA049_1189	COG1451	nucleotide metabolic process
VAA049_119	COG0783	Belongs to the Dps family
VAA049_1192	COG3063	Type IV pilus biogenesis stability protein PilW
VAA049_1193	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
VAA049_1197	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAA049_1200	COG3290	protein histidine kinase activity
VAA049_1201	COG4565	transcriptional regulatory protein
VAA049_1203	COG0835	chemotaxis
VAA049_1203	COG0784	Response regulator, receiver
VAA049_1206	COG0745	RESPONSE REGULATOR receiver
VAA049_1206	COG3706	GGDEF domain
VAA049_1211	COG1085	galactose-1-phosphate uridylyltransferase
VAA049_1212	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VAA049_1213	COG2017	converts alpha-aldose to the beta-anomer
VAA049_1214	COG3706	GGDEF domain
VAA049_1215	COG2199	diguanylate cyclase activity
VAA049_1215	COG2200	EAL domain
VAA049_1218	COG3527	Alpha-acetolactate decarboxylase
VAA049_1221	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VAA049_1223	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VAA049_1231	COG1271	oxidase subunit
VAA049_1232	COG1294	oxidase, subunit
VAA049_1233	COG1136	(ABC) transporter
VAA049_1233	COG4591	ABC-type transport system involved in lipoprotein release permease component
VAA049_1234	COG0577	efflux transmembrane transporter activity
VAA049_1234	COG1136	(ABC) transporter
VAA049_1239	COG0583	DNA-binding transcription factor activity
VAA049_124	COG0742	ribosomal rna small subunit methyltransferase
VAA049_1240	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
VAA049_1241	COG2723	6-phospho-beta-galactosidase activity
VAA049_1242	COG1609	Transcriptional regulator
VAA049_1243	COG0251	oxidation-reduction process
VAA049_1244	COG2731	YhcH YjgK YiaL family protein
VAA049_1245	COG0584	glycerophosphoryl diester phosphodiesterase
VAA049_1246	COG1349	DNA-binding transcription factor activity
VAA049_1247	COG3842	ATPase activity
VAA049_1248	COG0395	ABC-type sugar transport system, permease component
VAA049_1249	COG1175	transmembrane transport
VAA049_125	COG0552	protein localization to endoplasmic reticulum
VAA049_1252	COG0811	peptide transport
VAA049_1253	COG0811	peptide transport
VAA049_1254	COG0848	biopolymer transport protein
VAA049_1255	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VAA049_1257	COG1793	dna ligase
VAA049_1259	COG0534	Mate efflux family protein
VAA049_126	COG2884	Cell division ATP-binding protein ftsE
VAA049_1263	COG0791	NLP P60 protein
VAA049_1264	COG0840	transmembrane signaling receptor activity
VAA049_1267	COG1940	carbohydrate kinase activity
VAA049_127	COG2177	Part of the ABC transporter FtsEX involved in
VAA049_1270	COG0303	'Molybdopterin
VAA049_1271	COG0746	molybdenum cofactor guanylyltransferase activity
VAA049_1272	COG3842	ATPase activity
VAA049_1273	COG4662	Binding-protein-dependent transport system inner membrane component
VAA049_1275	COG2204	response regulator
VAA049_1276	COG3852	Histidine kinase
VAA049_1277	COG0488	(ABC) transporter
VAA049_1278	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VAA049_128	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VAA049_1284	COG0243	molybdopterin cofactor binding
VAA049_1284	COG3383	formate dehydrogenase (NAD+) activity
VAA049_1285	COG0437	4 iron, 4 sulfur cluster binding
VAA049_1288	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VAA049_129	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VAA049_1290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VAA049_1293	COG2996	Protein conserved in bacteria
VAA049_1294	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VAA049_1294	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
VAA049_1295	COG3008	intermembrane lipid transfer
VAA049_1296	COG2995	paraquat-inducible protein a
VAA049_1297	COG1132	(ABC) transporter
VAA049_1298	COG1956	GAF domain-containing protein
VAA049_1299	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VAA049_13	COG0425	Belongs to the sulfur carrier protein TusA family
VAA049_1302	COG0308	aminopeptidase N
VAA049_1304	COG0167	dihydroorotate dehydrogenase activity
VAA049_1306	COG0116	Belongs to the methyltransferase superfamily
VAA049_1306	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VAA049_1311	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VAA049_1312	COG1067	ATP-dependent peptidase activity
VAA049_1313	COG3120	sequence-specific DNA binding
VAA049_132	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VAA049_134	COG1404	Belongs to the peptidase S8 family
VAA049_1356	COG3064	Membrane
VAA049_1356	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
VAA049_1356	COG1073	alpha beta
VAA049_1357	COG2994	toxin metabolic process
VAA049_136	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VAA049_1362	COG0784	Response regulator, receiver
VAA049_1362	COG2205	protein histidine kinase activity
VAA049_1365	COG3278	Belongs to the heme-copper respiratory oxidase family
VAA049_1368	COG2010	Cytochrome c
VAA049_1370	COG2217	Heavy metal translocating P-type atpase
VAA049_1373	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VAA049_1374	COG0589	response to stress
VAA049_1375	COG0037	tRNA processing
VAA049_1379	COG3842	ATPase activity
VAA049_1380	COG1176	ABC-type spermidine putrescine transport system, permease component I
VAA049_1381	COG1177	transmembrane transport
VAA049_1382	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VAA049_1383	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VAA049_1386	COG1115	amino acid carrier protein
VAA049_1387	COG1280	lysine exporter protein (LysE YggA)
VAA049_1391	COG3501	Rhs element vgr protein
VAA049_1393	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VAA049_1394	COG0840	transmembrane signaling receptor activity
VAA049_1395	COG2814	Major facilitator Superfamily
VAA049_1396	COG1566	PFAM secretion protein HlyD family protein
VAA049_1397	COG1538	Outer membrane efflux protein
VAA049_1399	COG0513	Belongs to the DEAD box helicase family
VAA049_1401	COG0840	transmembrane signaling receptor activity
VAA049_1402	COG0840	transmembrane signaling receptor activity
VAA049_1402	COG3290	protein histidine kinase activity
VAA049_1403	COG0835	chemotaxis
VAA049_1404	COG2201	protein-glutamate methylesterase activity
VAA049_1406	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VAA049_1408	COG2198	Histidine kinase
VAA049_1408	COG0643	Histidine kinase
VAA049_1412	COG2076	Multidrug Resistance protein
VAA049_1413	COG0415	Belongs to the DNA photolyase family
VAA049_1414	COG0477	Major facilitator Superfamily
VAA049_1415	COG0583	DNA-binding transcription factor activity
VAA049_1416	COG0095	Lipoate-protein ligase
VAA049_1417	COG0443	Heat shock 70 kDa protein
VAA049_1419	COG1643	Atp-dependent helicase
VAA049_1426	COG0443	Heat shock 70 kDa protein
VAA049_1427	COG0443	Heat shock 70 kDa protein
VAA049_1428	COG3706	GGDEF domain
VAA049_1433	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VAA049_1435	COG0602	queuosine metabolic process
VAA049_1437	COG0561	phosphatase activity
VAA049_1439	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAA049_1440	COG4597	amino acid ABC transporter
VAA049_1441	COG0765	amino acid transport
VAA049_1442	COG1126	abc transporter atp-binding protein
VAA049_1443	COG0670	Belongs to the BI1 family
VAA049_1444	COG2920	part of a sulfur-relay system
VAA049_1445	COG1254	Belongs to the acylphosphatase family
VAA049_1446	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VAA049_1447	COG3706	GGDEF domain
VAA049_1449	COG3437	response regulator, receiver
VAA049_1449	COG4999	Histidine kinase
VAA049_1449	COG3850	Histidine kinase
VAA049_1449	COG2205	protein histidine kinase activity
VAA049_1450	COG0625	glutathione transferase activity
VAA049_1451	COG3437	response regulator, receiver
VAA049_1453	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VAA049_1455	COG2195	Cleaves the N-terminal amino acid of tripeptides
VAA049_1461	COG0372	Belongs to the citrate synthase family
VAA049_1462	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VAA049_1463	COG2186	Transcriptional regulator
VAA049_1470	COG1129	ABC transporter
VAA049_1475	COG0745	RESPONSE REGULATOR receiver
VAA049_1476	COG5002	protein histidine kinase activity
VAA049_1477	COG3713	MltA-interacting MipA family protein
VAA049_1478	COG2990	Protein conserved in bacteria
VAA049_1480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAA049_1480	COG4191	Histidine kinase
VAA049_1481	COG0471	metal ion transport
VAA049_1483	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VAA049_1486	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VAA049_1487	COG3283	Transcriptional regulator of aromatic amino acids metabolism
VAA049_1488	COG3768	UPF0283 membrane protein
VAA049_1489	COG3106	COG3106 Predicted ATPase
VAA049_149	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VAA049_1492	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VAA049_1493	COG0494	nUDIX hydrolase
VAA049_1494	COG0814	amino acid
VAA049_1495	COG1760	l-serine dehydratase
VAA049_1496	COG0720	synthase
VAA049_1497	COG0840	transmembrane signaling receptor activity
VAA049_1498	COG0017	Asparaginyl-tRNA synthetase
VAA049_1499	COG0351	phosphomethylpyrimidine kinase
VAA049_15	COG0604	alcohol dehydrogenase
VAA049_150	COG5001	Diguanylate cyclase
VAA049_150	COG3300	MHYT domain
VAA049_1500	COG3437	response regulator, receiver
VAA049_1500	COG2770	Histidine kinase
VAA049_1501	COG1448	Aminotransferase
VAA049_1504	COG0840	transmembrane signaling receptor activity
VAA049_1505	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
VAA049_1506	COG2943	transferase activity, transferring hexosyl groups
VAA049_1507	COG1609	Transcriptional regulator
VAA049_1508	COG3394	polysaccharide catabolic process
VAA049_1509	COG1486	melibiose metabolic process
VAA049_1510	COG1447	Phosphotransferase system cellobiose-specific component IIA
VAA049_1512	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VAA049_1513	COG0726	polysaccharide deacetylase
VAA049_1514	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VAA049_1515	COG1846	Transcriptional regulator
VAA049_152	COG3852	Histidine kinase
VAA049_1520	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VAA049_1522	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VAA049_1524	COG3108	Peptidase M15
VAA049_1530	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VAA049_1532	COG2814	Major facilitator Superfamily
VAA049_1536	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VAA049_1537	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VAA049_1538	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VAA049_154	COG0174	glutamine synthetase
VAA049_1546	COG2801	Transposase and inactivated derivatives
VAA049_1548	COG1418	mRNA catabolic process
VAA049_1572	COG4115	mRNA cleavage
VAA049_1573	COG2161	toxin-antitoxin pair type II binding
VAA049_1586	COG0456	acetyltransferase
VAA049_159	COG1490	D-aminoacyl-tRNA deacylase activity
VAA049_1591	COG5002	protein histidine kinase activity
VAA049_1595	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
VAA049_1596	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VAA049_1598	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VAA049_160	COG0456	acetyltransferase
VAA049_162	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VAA049_1627	COG3772	lysozyme
VAA049_163	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VAA049_1631	COG3646	Phage regulatory protein
VAA049_164	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VAA049_1648	COG0404	The glycine cleavage system catalyzes the degradation of glycine
VAA049_165	COG3031	protein transport across the cell outer membrane
VAA049_1650	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VAA049_1651	COG0509	glycine decarboxylation via glycine cleavage system
VAA049_1652	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VAA049_1652	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VAA049_1653	COG3338	carbonate dehydratase activity
VAA049_1656	COG1686	Belongs to the peptidase S11 family
VAA049_1660	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VAA049_1665	COG5002	protein histidine kinase activity
VAA049_1665	COG5000	phosphorelay sensor kinase activity
VAA049_1666	COG0745	RESPONSE REGULATOR receiver
VAA049_167	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VAA049_1671	COG0366	Alpha amylase catalytic
VAA049_1678	COG0561	phosphatase activity
VAA049_1679	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
VAA049_168	COG1459	type II secretion system
VAA049_1680	COG3623	hexulose-6-phosphate isomerase
VAA049_1682	COG0745	RESPONSE REGULATOR receiver
VAA049_1686	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VAA049_169	COG2165	general secretion pathway protein
VAA049_1690	COG4604	ABC transporter, ATP-binding protein
VAA049_1691	COG4605	iron ion homeostasis
VAA049_1692	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VAA049_1698	COG4412	M6 family metalloprotease domain protein
VAA049_1698	COG3291	Pkd domain containing protein
VAA049_1699	COG5380	lipid catabolic process
VAA049_17	COG0129	dihydroxy-acid dehydratase activity
VAA049_170	COG2165	general secretion pathway protein
VAA049_1700	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
VAA049_1701	COG0840	transmembrane signaling receptor activity
VAA049_1703	COG3240	lipase activity
VAA049_1705	COG3706	GGDEF domain
VAA049_1706	COG2814	Major facilitator Superfamily
VAA049_1707	COG1757	Na H antiporter
VAA049_1709	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAA049_1709	COG4191	Histidine kinase
VAA049_171	COG2165	general secretion pathway protein
VAA049_1710	COG0784	Response regulator, receiver
VAA049_1710	COG3437	response regulator, receiver
VAA049_1711	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VAA049_1712	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VAA049_1713	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VAA049_1714	COG0513	Belongs to the DEAD box helicase family
VAA049_172	COG4795	General secretion pathway protein
VAA049_1721	COG0516	GMP reductase activity
VAA049_1723	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VAA049_1725	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
VAA049_1725	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
VAA049_1726	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VAA049_173	COG3156	type II secretion system protein K
VAA049_1731	COG3036	rescue of stalled ribosome
VAA049_1732	COG1278	Cold shock
VAA049_1733	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VAA049_1733	COG1017	nitric oxide dioxygenase activity
VAA049_1735	COG3604	Transcriptional regulator
VAA049_1736	COG2195	Cleaves the N-terminal amino acid of tripeptides
VAA049_1737	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VAA049_174	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VAA049_1740	COG0840	transmembrane signaling receptor activity
VAA049_1741	COG0714	Associated with various cellular activities
VAA049_1745	COG2304	oxidoreductase activity
VAA049_1748	COG1278	Cold shock
VAA049_1749	COG5002	protein histidine kinase activity
VAA049_1749	COG5001	Diguanylate cyclase
VAA049_175	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VAA049_1751	COG3530	Putative quorum-sensing-regulated virulence factor
VAA049_1753	COG3033	Beta-eliminating lyase
VAA049_1754	COG0814	amino acid
VAA049_1755	COG0589	response to stress
VAA049_1757	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VAA049_1757	COG2111	Na H antiporter
VAA049_1761	COG2212	antiporter activity
VAA049_1762	COG1320	monovalent cation:proton antiporter activity
VAA049_1764	COG0242	peptide deformylase activity
VAA049_1766	COG0579	oxidoreductase
VAA049_177	COG1218	3'(2'),5'-bisphosphate nucleotidase
VAA049_1773	COG2271	Major facilitator Superfamily
VAA049_1774	COG0584	glycerophosphoryl diester phosphodiesterase
VAA049_1776	COG3447	MASE1 domain protein
VAA049_1776	COG5002	protein histidine kinase activity
VAA049_1776	COG5001	Diguanylate cyclase
VAA049_1777	COG1609	Transcriptional regulator
VAA049_1778	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VAA049_1779	COG1879	ABC-type sugar transport system periplasmic component
VAA049_178	COG0494	nUDIX hydrolase
VAA049_1780	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAA049_1781	COG1129	ABC transporter
VAA049_1782	COG1869	D-ribose catabolic process
VAA049_1785	COG2801	Transposase and inactivated derivatives
VAA049_1786	COG3501	Rhs element vgr protein
VAA049_179	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VAA049_179	COG0316	Belongs to the HesB IscA family
VAA049_18	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VAA049_180	COG1040	competence protein
VAA049_1804	COG0564	pseudouridine synthase activity
VAA049_1806	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VAA049_1807	COG2200	EAL domain
VAA049_1807	COG2771	luxR family
VAA049_1809	COG0673	inositol 2-dehydrogenase activity
VAA049_181	COG0596	Alpha beta hydrolase
VAA049_1810	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
VAA049_1816	COG1342	Belongs to the UPF0251 family
VAA049_1818	COG1301	dicarboxylic acid transport
VAA049_1823	COG2814	Major facilitator Superfamily
VAA049_1824	COG0583	DNA-binding transcription factor activity
VAA049_1826	COG3300	MHYT domain
VAA049_1826	COG5001	Diguanylate cyclase
VAA049_1827	COG0739	heme binding
VAA049_1829	COG0659	secondary active sulfate transmembrane transporter activity
VAA049_183	COG2183	response to ionizing radiation
VAA049_1833	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VAA049_1834	COG0581	inorganic phosphate transmembrane transporter activity
VAA049_1835	COG0573	inorganic phosphate transmembrane transporter activity
VAA049_1836	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VAA049_184	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VAA049_1842	COG1770	oligopeptidase
VAA049_1843	COG0513	Belongs to the DEAD box helicase family
VAA049_1845	COG1388	LysM domain
VAA049_1845	COG1376	ErfK ybiS ycfS ynhG family protein
VAA049_1846	COG0415	Belongs to the DNA photolyase family
VAA049_1848	COG3272	Protein of unknown function (DUF1722)
VAA049_1849	COG0813	purine-nucleoside phosphorylase activity
VAA049_1852	COG3706	GGDEF domain
VAA049_1854	COG1566	PFAM secretion protein HlyD family protein
VAA049_1858	COG0786	glutamate:sodium symporter activity
VAA049_1861	COG1999	signal sequence binding
VAA049_1863	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
VAA049_1864	COG0671	phosphoesterase, PA-phosphatase related
VAA049_187	COG1129	ABC transporter
VAA049_1872	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VAA049_1873	COG0471	metal ion transport
VAA049_188	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAA049_1880	COG3501	Rhs element vgr protein
VAA049_1882	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VAA049_1883	COG1640	4-alpha-glucanotransferase
VAA049_1884	COG0058	SHG alpha-glucan phosphorylase activity
VAA049_1885	COG2909	trisaccharide binding
VAA049_1888	COG2084	Dehydrogenase
VAA049_1889	COG0217	transcriptional regulatory protein
VAA049_189	COG1472	Belongs to the glycosyl hydrolase 3 family
VAA049_1896	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VAA049_1897	COG1444	tRNA N-acetyltransferase activity
VAA049_1901	COG4221	oxidoreductase activity
VAA049_1903	COG0745	RESPONSE REGULATOR receiver
VAA049_1904	COG0642	Histidine kinase
VAA049_1905	COG2194	sulfuric ester hydrolase activity
VAA049_1907	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAA049_1908	COG0601	transmembrane transport
VAA049_1912	COG2198	Histidine kinase
VAA049_1912	COG0643	Histidine kinase
VAA049_1913	COG0835	chemotaxis
VAA049_1914	COG0835	chemotaxis
VAA049_1915	COG0840	transmembrane signaling receptor activity
VAA049_1916	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VAA049_1917	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
VAA049_192	COG0745	RESPONSE REGULATOR receiver
VAA049_1927	COG0259	pyridoxamine-phosphate oxidase activity
VAA049_1929	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VAA049_1934	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VAA049_1939	COG1982	Orn Lys Arg decarboxylase major
VAA049_194	COG2233	PERMEase
VAA049_1940	COG0531	amino acid
VAA049_1941	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VAA049_1942	COG1901	pseudouridine methyltransferase
VAA049_1944	COG4221	oxidoreductase activity
VAA049_1945	COG0840	transmembrane signaling receptor activity
VAA049_1947	COG2910	NAD(P)H-binding
VAA049_1949	COG1335	isochorismatase
VAA049_195	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VAA049_1952	COG0697	spore germination
VAA049_1956	COG0673	inositol 2-dehydrogenase activity
VAA049_1957	COG3722	fumarate hydratase activity
VAA049_1958	COG0246	Mannitol dehydrogenase
VAA049_1959	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAA049_1959	COG2213	PTS system mannitol-specific
VAA049_196	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VAA049_1960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VAA049_1961	COG4597	amino acid ABC transporter
VAA049_1962	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAA049_1964	COG1126	abc transporter atp-binding protein
VAA049_1965	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VAA049_1967	COG0840	transmembrane signaling receptor activity
VAA049_197	COG1758	RNA polymerase activity
VAA049_1970	COG0840	transmembrane signaling receptor activity
VAA049_1973	COG4580	involved in the transport of maltose and maltodextrins
VAA049_1976	COG0363	glucosamine-6-phosphate deaminase activity
VAA049_198	COG0194	GDP metabolic process
VAA049_1981	COG2259	Doxx family
VAA049_1982	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
VAA049_1983	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VAA049_1985	COG0471	metal ion transport
VAA049_1987	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
VAA049_1988	COG4565	transcriptional regulatory protein
VAA049_1989	COG3366	ferrous iron transmembrane transporter activity
VAA049_199	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VAA049_1990	COG0700	Nucleoside recognition
VAA049_1992	COG0697	spore germination
VAA049_1993	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VAA049_1994	COG1764	response to oxidative stress
VAA049_1995	COG1846	Transcriptional regulator
VAA049_1999	COG2207	Transcriptional regulator
VAA049_2	COG0592	DNA-directed DNA polymerase activity
VAA049_200	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VAA049_2000	COG1280	lysine exporter protein (LysE YggA)
VAA049_2002	COG1902	pentaerythritol trinitrate reductase activity
VAA049_2004	COG1132	(ABC) transporter
VAA049_2006	COG0513	Belongs to the DEAD box helicase family
VAA049_2007	COG0534	Mate efflux family protein
VAA049_2008	COG0840	transmembrane signaling receptor activity
VAA049_2010	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
VAA049_2012	COG1304	FMN binding
VAA049_2013	COG1620	l-lactate permease
VAA049_2014	COG0583	DNA-binding transcription factor activity
VAA049_2018	COG4172	Belongs to the ABC transporter superfamily
VAA049_202	COG3263	regulation of cellular component size
VAA049_2020	COG1067	ATP-dependent peptidase activity
VAA049_2021	COG0840	transmembrane signaling receptor activity
VAA049_2023	COG2211	Major facilitator Superfamily
VAA049_2025	COG3123	guanosine phosphorylase activity
VAA049_2026	COG1741	Belongs to the pirin family
VAA049_2028	COG5001	Diguanylate cyclase
VAA049_2029	COG0583	DNA-binding transcription factor activity
VAA049_2036	COG3706	GGDEF domain
VAA049_2037	COG1846	Transcriptional regulator
VAA049_2038	COG0835	chemotaxis
VAA049_2038	COG0784	Response regulator, receiver
VAA049_2039	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VAA049_204	COG4232	protein-disulfide reductase activity
VAA049_2040	COG2197	response regulator
VAA049_2041	COG0393	Putative heavy-metal-binding
VAA049_2044	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VAA049_2045	COG3842	ATPase activity
VAA049_2047	COG1175	transmembrane transport
VAA049_2048	COG3833	ABC-type maltose transport systems, permease component
VAA049_2051	COG1349	DNA-binding transcription factor activity
VAA049_2052	COG3706	GGDEF domain
VAA049_2057	COG1278	Cold shock
VAA049_2059	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VAA049_206	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VAA049_2060	COG2354	Protein conserved in bacteria
VAA049_2061	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VAA049_2063	COG3152	Membrane
VAA049_2065	COG0418	dihydroorotase activity
VAA049_2066	COG0633	Ferredoxin
VAA049_2066	COG3217	Mosc domain protein beta barrel domain protein
VAA049_2066	COG0633	Ferredoxin
VAA049_2066	COG3217	Mosc domain protein beta barrel domain protein
VAA049_207	COG1027	Aspartate ammonia-lyase
VAA049_2073	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VAA049_2074	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VAA049_2075	COG4558	Periplasmic binding protein
VAA049_2076	COG0848	biopolymer transport protein
VAA049_2077	COG0811	peptide transport
VAA049_2078	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VAA049_208	COG3706	GGDEF domain
VAA049_2080	COG3721	Heme iron utilization protein
VAA049_2081	COG0748	coenzyme F420 binding
VAA049_2083	COG3835	regulator
VAA049_2084	COG2610	gluconate transmembrane transporter activity
VAA049_2085	COG1929	Belongs to the glycerate kinase type-1 family
VAA049_209	COG3030	protein affecting phage T7 exclusion by the F plasmid
VAA049_2090	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VAA049_2091	COG0363	glucosamine-6-phosphate deaminase activity
VAA049_2092	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VAA049_2093	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VAA049_2094	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
VAA049_2098	COG0346	lactoylglutathione lyase activity
VAA049_21	COG0606	chelatase, subunit chli
VAA049_210	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VAA049_2100	COG2873	o-acetylhomoserine
VAA049_2102	COG1063	alcohol dehydrogenase
VAA049_2112	COG0583	DNA-binding transcription factor activity
VAA049_2113	COG3048	D-serine ammonia-lyase activity
VAA049_2116	COG1294	oxidase, subunit
VAA049_2117	COG1271	oxidase subunit
VAA049_2118	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAA049_2119	COG1686	Belongs to the peptidase S11 family
VAA049_212	COG2205	protein histidine kinase activity
VAA049_2122	COG3047	cAMP biosynthetic process
VAA049_2123	COG3227	Zinc metalloprotease (Elastase)
VAA049_2125	COG2267	carboxylic ester hydrolase activity
VAA049_2126	COG2067	long-chain fatty acid transport protein
VAA049_2127	COG0366	Alpha amylase catalytic
VAA049_2128	COG4989	oxidoreductase activity
VAA049_213	COG0745	RESPONSE REGULATOR receiver
VAA049_2130	COG3706	GGDEF domain
VAA049_2131	COG0531	amino acid
VAA049_2136	COG1765	OsmC-like protein
VAA049_2137	COG1253	flavin adenine dinucleotide binding
VAA049_2138	COG2171	N-acyltransferase activity
VAA049_2141	COG0583	DNA-binding transcription factor activity
VAA049_2142	COG2264	protein methyltransferase activity
VAA049_2145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VAA049_2146	COG3186	Phenylalanine-4-hydroxylase
VAA049_2147	COG2154	pterin-4-alpha-carbinolamine dehydratase
VAA049_2148	COG0456	acetyltransferase
VAA049_2149	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VAA049_215	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VAA049_2150	COG0662	Cupin 2, conserved barrel domain protein
VAA049_2151	COG0527	aspartate kinase activity
VAA049_2153	COG0459	protein refolding
VAA049_2154	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VAA049_2155	COG2239	Acts as a magnesium transporter
VAA049_2157	COG1166	arginine decarboxylase activity
VAA049_2158	COG0010	Belongs to the arginase family
VAA049_216	COG0205	6-phosphofructokinase activity
VAA049_2160	COG3227	Zinc metalloprotease (Elastase)
VAA049_2161	COG3397	chitin binding
VAA049_2162	COG3046	protein related to deoxyribodipyrimidine photolyase
VAA049_2164	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VAA049_2166	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
VAA049_2167	COG0513	Belongs to the DEAD box helicase family
VAA049_2169	COG1368	sulfuric ester hydrolase activity
VAA049_217	COG1494	fructose-1,6-bisphosphatase
VAA049_2170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VAA049_2173	COG0546	phosphoglycolate phosphatase activity
VAA049_2177	COG0484	heat shock protein binding
VAA049_2179	COG1716	ATPase activity
VAA049_2179	COG5001	Diguanylate cyclase
VAA049_218	COG3074	FtsZ-dependent cytokinesis
VAA049_2180	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VAA049_2182	COG4181	ATPase activity
VAA049_2183	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
VAA049_2186	COG1984	allophanate hydrolase subunit 2
VAA049_2188	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VAA049_2189	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VAA049_219	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VAA049_2190	COG0840	transmembrane signaling receptor activity
VAA049_2191	COG0814	amino acid
VAA049_2193	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
VAA049_2194	COG0513	Belongs to the DEAD box helicase family
VAA049_2195	COG1309	transcriptional regulator
VAA049_2197	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
VAA049_2198	COG0494	nUDIX hydrolase
VAA049_22	COG0204	Acyl-transferase
VAA049_220	COG0527	aspartate kinase activity
VAA049_220	COG0460	homoserine dehydrogenase
VAA049_2200	COG2425	protein containing a von Willebrand factor type A (vWA) domain
VAA049_2202	COG1126	abc transporter atp-binding protein
VAA049_2203	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAA049_2204	COG4215	(ABC) transporter
VAA049_2205	COG4160	amino acid transport
VAA049_2206	COG0583	DNA-binding transcription factor activity
VAA049_221	COG0626	cystathionine gamma-synthase activity
VAA049_2212	COG3118	belongs to the thioredoxin family
VAA049_2213	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VAA049_2214	COG0247	lactate metabolic process
VAA049_2216	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VAA049_2217	COG1879	ABC-type sugar transport system periplasmic component
VAA049_2219	COG5002	protein histidine kinase activity
VAA049_2219	COG0784	Response regulator, receiver
VAA049_222	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
VAA049_2224	COG1492	cobalamin metabolic process
VAA049_2225	COG0725	ABC transporter, periplasmic molybdate-binding protein
VAA049_2226	COG4149	molybdate abc transporter
VAA049_2227	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
VAA049_223	COG0281	malic enzyme
VAA049_2233	COG1289	transmembrane transporter activity
VAA049_2234	COG0210	DNA helicase
VAA049_2237	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VAA049_2238	COG1335	isochorismatase
VAA049_2239	COG1803	Methylglyoxal synthase
VAA049_224	COG0254	rRNA binding
VAA049_2240	COG1879	ABC-type sugar transport system periplasmic component
VAA049_2241	COG0784	Response regulator, receiver
VAA049_2241	COG2198	Histidine kinase
VAA049_2241	COG2205	protein histidine kinase activity
VAA049_2242	COG0469	pyruvate kinase activity
VAA049_2243	COG2271	Major facilitator Superfamily
VAA049_2245	COG1840	ABC-type Fe3 transport system, periplasmic component
VAA049_2246	COG4191	Histidine kinase
VAA049_2249	COG1979	alcohol dehydrogenase
VAA049_225	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VAA049_2251	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VAA049_2252	COG3706	GGDEF domain
VAA049_2255	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VAA049_2256	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VAA049_2258	COG0183	Belongs to the thiolase family
VAA049_226	COG1609	Transcriptional regulator
VAA049_2260	COG3243	poly(R)-hydroxyalkanoic acid synthase
VAA049_2261	COG3842	ATPase activity
VAA049_2263	COG1840	ABC-type Fe3 transport system, periplasmic component
VAA049_2264	COG2271	Major facilitator Superfamily
VAA049_2265	COG3851	Histidine kinase
VAA049_2266	COG2197	response regulator
VAA049_2267	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VAA049_227	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VAA049_2271	COG0243	molybdopterin cofactor binding
VAA049_2273	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VAA049_2274	COG3850	Histidine kinase
VAA049_2275	COG2197	response regulator
VAA049_2276	COG1760	l-serine dehydratase
VAA049_2277	COG3069	C4-dicarboxylate transmembrane transporter activity
VAA049_2278	COG0840	transmembrane signaling receptor activity
VAA049_2279	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VAA049_228	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VAA049_2280	COG0545	Peptidyl-prolyl cis-trans isomerase
VAA049_2281	COG2885	chlorophyll binding
VAA049_2283	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VAA049_2284	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VAA049_2285	COG1621	beta-fructofuranosidase activity
VAA049_2287	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VAA049_2287	COG1263	PTS System
VAA049_229	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VAA049_2296	COG0446	pyridine nucleotide-disulphide oxidoreductase
VAA049_2298	COG0640	Transcriptional regulator
VAA049_23	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VAA049_230	COG1575	Belongs to the MenA family. Type 1 subfamily
VAA049_2303	COG0778	Nitroreductase
VAA049_2304	COG0583	DNA-binding transcription factor activity
VAA049_2305	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
VAA049_231	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VAA049_2310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VAA049_2316	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VAA049_2317	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VAA049_2318	COG2390	Transcriptional regulator
VAA049_2320	COG2897	thiosulfate sulfurtransferase activity
VAA049_2322	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VAA049_2324	COG0302	gtp cyclohydrolase
VAA049_2325	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAA049_2325	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAA049_2326	COG2759	Belongs to the formate--tetrahydrofolate ligase family
VAA049_2327	COG1970	mechanosensitive ion channel activity
VAA049_2328	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
VAA049_233	COG0149	triose-phosphate isomerase activity
VAA049_2330	COG1011	Hydrolase
VAA049_2331	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VAA049_2332	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VAA049_2334	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VAA049_2336	COG3842	ATPase activity
VAA049_2345	COG4166	transmembrane transport
VAA049_2346	COG4174	ABC transporter (Permease)
VAA049_2347	COG4239	(ABC) transporter, permease
VAA049_2348	COG4172	Belongs to the ABC transporter superfamily
VAA049_2349	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VAA049_2352	COG0625	glutathione transferase activity
VAA049_2356	COG2050	protein possibly involved in aromatic compounds catabolism
VAA049_2359	COG4771	TonB-dependent receptor
VAA049_2359	COG1629	transport
VAA049_2360	COG0583	DNA-binding transcription factor activity
VAA049_2361	COG0045	succinate-CoA ligase (ADP-forming) activity
VAA049_2361	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VAA049_2361	COG1042	CoA-binding domain protein
VAA049_2363	COG1181	Belongs to the D-alanine--D-alanine ligase family
VAA049_2365	COG0023	Translation Initiation Factor
VAA049_238	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VAA049_2380	COG0745	RESPONSE REGULATOR receiver
VAA049_2382	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VAA049_2383	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VAA049_2387	COG3706	GGDEF domain
VAA049_239	COG0459	protein refolding
VAA049_2396	COG2824	Alkylphosphonate utilization operon protein PhnA
VAA049_24	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VAA049_2400	COG0737	Belongs to the 5'-nucleotidase family
VAA049_2401	COG3593	DNA synthesis involved in DNA repair
VAA049_2403	COG0583	DNA-binding transcription factor activity
VAA049_2404	COG2116	formate transmembrane transporter activity
VAA049_2406	COG3038	cytochrome b561
VAA049_2408	COG2200	EAL domain
VAA049_241	COG1509	lysine 2,3-aminomutase activity
VAA049_2410	COG0586	Pfam SNARE associated Golgi protein
VAA049_2411	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VAA049_2412	COG0745	RESPONSE REGULATOR receiver
VAA049_2413	COG2205	protein histidine kinase activity
VAA049_2414	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VAA049_2414	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
VAA049_2414	COG1013	pyruvate-flavodoxin oxidoreductase activity
VAA049_2414	COG0674	pyruvate-flavodoxin oxidoreductase activity
VAA049_2415	COG3158	transport of potassium into the cell
VAA049_2417	COG0523	cobalamin synthesis protein
VAA049_2418	COG0038	chloride channel
VAA049_242	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VAA049_2420	COG0156	8-amino-7-oxononanoate synthase activity
VAA049_2421	COG0784	Response regulator, receiver
VAA049_2421	COG2205	protein histidine kinase activity
VAA049_2422	COG0419	ATPase involved in DNA repair
VAA049_2423	COG0420	3'-5' exonuclease activity
VAA049_2424	COG1609	Transcriptional regulator
VAA049_2425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAA049_2425	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAA049_2426	COG1105	Belongs to the carbohydrate kinase PfkB family
VAA049_2427	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VAA049_2427	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
VAA049_2427	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VAA049_2428	COG0189	ligase activity
VAA049_2428	COG4067	protein conserved in archaea
VAA049_243	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VAA049_2430	COG0602	queuosine metabolic process
VAA049_2431	COG1328	CTP reductase activity
VAA049_2433	COG2801	Transposase and inactivated derivatives
VAA049_244	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VAA049_2444	COG4977	sequence-specific DNA binding
VAA049_2449	COG1619	proteins homologs of microcin C7 resistance protein MccF
VAA049_245	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VAA049_2457	COG2801	Transposase and inactivated derivatives
VAA049_246	COG1053	succinate dehydrogenase
VAA049_247	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VAA049_2474	COG0110	maltose O-acetyltransferase activity
VAA049_2479	COG0456	acetyltransferase
VAA049_248	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VAA049_2481	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VAA049_2483	COG0384	phenazine biosynthesis protein PhzF
VAA049_249	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VAA049_2492	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VAA049_2498	COG2801	Transposase and inactivated derivatives
VAA049_250	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VAA049_2501	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
VAA049_2502	COG4139	cobalamin transport
VAA049_2503	COG2988	succinylglutamate desuccinylase activity
VAA049_2506	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VAA049_2507	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VAA049_2508	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAA049_251	COG1045	serine acetyltransferase
VAA049_2510	COG2925	Exonuclease
VAA049_2512	COG1346	cytolysis
VAA049_2513	COG0295	cytidine deaminase activity
VAA049_2515	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VAA049_2516	COG0500	methyltransferase
VAA049_2519	COG0776	regulation of translation
VAA049_2520	COG0072	phenylalanine-tRNA ligase activity
VAA049_2520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VAA049_2521	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VAA049_2522	COG0745	RESPONSE REGULATOR receiver
VAA049_2522	COG3706	GGDEF domain
VAA049_2529	COG0322	excinuclease ABC activity
VAA049_253	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VAA049_2530	COG2197	response regulator
VAA049_2531	COG5001	Diguanylate cyclase
VAA049_2532	COG0417	DNA replication proofreading
VAA049_2534	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VAA049_2538	COG1228	amidohydrolase
VAA049_2539	COG0010	Belongs to the arginase family
VAA049_254	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VAA049_2540	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VAA049_2541	COG2986	histidine ammonia-lyase
VAA049_2545	COG0277	FAD linked oxidase domain protein
VAA049_2545	COG0247	lactate metabolic process
VAA049_2548	COG2885	chlorophyll binding
VAA049_255	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VAA049_2552	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VAA049_2554	COG0281	malic enzyme
VAA049_2556	COG2949	membrane
VAA049_2557	COG3706	GGDEF domain
VAA049_2558	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VAA049_256	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VAA049_2560	COG0492	ferredoxin-NADP+ reductase activity
VAA049_2561	COG4988	ABC transporter
VAA049_2562	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VAA049_2563	COG1187	pseudouridine synthase activity
VAA049_2564	COG0009	L-threonylcarbamoyladenylate synthase
VAA049_2565	COG0613	PHP domain protein
VAA049_2566	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VAA049_2567	COG0512	Glutamine amidotransferase of anthranilate synthase
VAA049_2568	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VAA049_2569	COG0135	phosphoribosylanthranilate isomerase activity
VAA049_2569	COG0134	indole-3-glycerol-phosphate synthase activity
VAA049_257	COG0137	argininosuccinate synthase activity
VAA049_2570	COG0133	tryptophan synthase activity
VAA049_2571	COG0159	tryptophan synthase activity
VAA049_2573	COG1435	thymidine kinase activity
VAA049_2574	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VAA049_2575	COG1801	Protein of unknown function DUF72
VAA049_2576	COG4106	trans-aconitate 2-methyltransferase activity
VAA049_2577	COG0500	methyltransferase
VAA049_2578	COG0189	ligase activity
VAA049_2578	COG4067	protein conserved in archaea
VAA049_258	COG0165	Argininosuccinate lyase
VAA049_2581	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VAA049_2583	COG3852	Histidine kinase
VAA049_2586	COG3070	regulator of competence-specific genes
VAA049_2588	COG2431	L-lysine efflux transmembrane transporter activity
VAA049_2590	COG0076	glutamate decarboxylase activity
VAA049_2591	COG1737	Transcriptional regulator
VAA049_2592	COG1012	belongs to the aldehyde dehydrogenase family
VAA049_2592	COG1454	alcohol dehydrogenase
VAA049_2593	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VAA049_2595	COG0542	response to heat
VAA049_2596	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VAA049_2597	COG1278	Cold shock
VAA049_2599	COG1187	pseudouridine synthase activity
VAA049_26	COG3084	Protein conserved in bacteria
VAA049_260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VAA049_2600	COG0140	phosphoribosyl-ATP diphosphatase activity
VAA049_2600	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VAA049_2601	COG0107	imidazoleglycerol-phosphate synthase activity
VAA049_2602	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VAA049_2603	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VAA049_2604	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VAA049_2604	COG0131	Imidazoleglycerol-phosphate dehydratase
VAA049_2605	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VAA049_2606	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VAA049_2607	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VAA049_2608	COG1757	Na H antiporter
VAA049_2609	COG2916	Histone family protein nucleoid-structuring protein H-NS
VAA049_261	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VAA049_261	COG0678	peroxiredoxin activity
VAA049_2610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VAA049_2611	COG0482	sulfurtransferase activity
VAA049_2612	COG2915	High frequency lysogenization protein hflD homolog
VAA049_2613	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VAA049_2615	COG2268	Band 7 protein
VAA049_2617	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VAA049_2620	COG0300	oxidoreductase activity
VAA049_2622	COG0501	Belongs to the peptidase M48B family
VAA049_2624	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VAA049_2625	COG2226	methyltransferase
VAA049_2626	COG0156	8-amino-7-oxononanoate synthase activity
VAA049_2627	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VAA049_2628	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VAA049_2629	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VAA049_263	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VAA049_2630	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VAA049_2631	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VAA049_2632	COG0653	protein targeting
VAA049_2633	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VAA049_2634	COG3706	GGDEF domain
VAA049_2636	COG4120	Belongs to the binding-protein-dependent transport system permease family
VAA049_2638	COG4628	conserved protein (DUF2132)
VAA049_2639	COG3092	negative regulation of chromosome organization
VAA049_2640	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VAA049_2641	COG0857	belongs to the CobB CobQ family
VAA049_2641	COG0280	phosphate acetyltransferase
VAA049_2642	COG0435	Glutathione S-transferase
VAA049_2645	COG0444	Belongs to the ABC transporter superfamily
VAA049_2646	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAA049_2647	COG0601	transmembrane transport
VAA049_2651	COG2204	response regulator
VAA049_2652	COG5001	Diguanylate cyclase
VAA049_2652	COG3300	MHYT domain
VAA049_2653	COG4191	Histidine kinase
VAA049_2654	COG5002	protein histidine kinase activity
VAA049_2656	COG2201	protein-glutamate methylesterase activity
VAA049_2659	COG0009	L-threonylcarbamoyladenylate synthase
VAA049_2662	COG1881	PFAM PEBP family protein
VAA049_2667	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VAA049_2668	COG0640	Transcriptional regulator
VAA049_2669	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VAA049_2670	COG0569	domain protein
VAA049_2673	COG0745	RESPONSE REGULATOR receiver
VAA049_2674	COG2205	protein histidine kinase activity
VAA049_2677	COG2801	Transposase and inactivated derivatives
VAA049_2679	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VAA049_2683	COG2801	Transposase and inactivated derivatives
VAA049_2685	COG3706	GGDEF domain
VAA049_2689	COG1946	Acyl-CoA thioesterase
VAA049_269	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VAA049_2690	COG1522	sequence-specific DNA binding
VAA049_2692	COG0616	signal peptide processing
VAA049_2693	COG1028	Short-chain dehydrogenase reductase Sdr
VAA049_2696	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VAA049_2697	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VAA049_2699	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VAA049_27	COG4326	sporulation control protein
VAA049_270	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VAA049_2700	COG2832	Protein of unknown function (DUF454)
VAA049_2702	COG0745	RESPONSE REGULATOR receiver
VAA049_2703	COG0583	DNA-binding transcription factor activity
VAA049_2704	COG0778	Nitroreductase
VAA049_2705	COG1024	Enoyl-CoA hydratase
VAA049_2705	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAA049_2706	COG0183	Belongs to the thiolase family
VAA049_2709	COG2067	long-chain fatty acid transport protein
VAA049_2711	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VAA049_2712	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VAA049_2713	COG2801	Transposase and inactivated derivatives
VAA049_2714	COG2982	Protein involved in outer membrane biogenesis
VAA049_2715	COG0572	uridine kinase
VAA049_2716	COG0489	protein tyrosine kinase activity
VAA049_2717	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VAA049_2717	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VAA049_2719	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VAA049_272	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VAA049_2721	COG4109	DRTGG domain
VAA049_2722	COG2199	diguanylate cyclase activity
VAA049_2723	COG0314	molybdopterin synthase activity
VAA049_2724	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VAA049_2725	COG0315	cyclic pyranopterin monophosphate synthase activity
VAA049_2726	COG0521	Mo-molybdopterin cofactor biosynthetic process
VAA049_2727	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VAA049_2728	COG2198	Histidine kinase
VAA049_2729	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VAA049_273	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VAA049_2730	COG2204	response regulator
VAA049_2731	COG0556	nucleotide-excision repair
VAA049_2733	COG4657	Part of a membrane complex involved in electron transport
VAA049_2734	COG2878	Part of a membrane complex involved in electron transport
VAA049_2735	COG4656	Part of a membrane complex involved in electron transport
VAA049_2736	COG4658	electron transport chain
VAA049_2737	COG4659	FMN binding
VAA049_2738	COG4660	Part of a membrane complex involved in electron transport
VAA049_2739	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VAA049_274	COG0546	phosphoglycolate phosphatase activity
VAA049_2740	COG0346	lactoylglutathione lyase activity
VAA049_2743	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VAA049_2744	COG2056	Na+-H+ antiporter family
VAA049_2745	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VAA049_2746	COG1286	toxin biosynthetic process
VAA049_2747	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VAA049_2748	COG0285	dihydrofolate synthase activity
VAA049_2749	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VAA049_275	COG0180	Tryptophanyl-tRNA synthetase
VAA049_2750	COG0101	tRNA pseudouridine synthase activity
VAA049_2752	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VAA049_2753	COG1263	PTS System
VAA049_2753	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VAA049_2753	COG2190	(PTS) system
VAA049_2754	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VAA049_2755	COG1846	Transcriptional regulator
VAA049_2755	COG1940	carbohydrate kinase activity
VAA049_2756	COG4651	solute:proton antiporter activity
VAA049_2756	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VAA049_2757	COG0367	asparagine synthase
VAA049_2760	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VAA049_2761	COG0563	adenylate kinase activity
VAA049_2762	COG0326	Molecular chaperone. Has ATPase activity
VAA049_2763	COG3710	Transcriptional regulator
VAA049_2766	COG0622	Phosphoesterase
VAA049_2767	COG1090	epimerase
VAA049_2768	COG0300	oxidoreductase activity
VAA049_2769	COG3118	belongs to the thioredoxin family
VAA049_2770	COG0330	HflC and HflK could
VAA049_2771	COG1585	Membrane protein implicated in regulation of membrane protease activity
VAA049_2772	COG0789	Transcriptional regulator
VAA049_2775	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VAA049_2776	COG3115	cell septum assembly
VAA049_2777	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VAA049_2778	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VAA049_2779	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAA049_278	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VAA049_2781	COG2190	(PTS) system
VAA049_2782	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAA049_2783	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VAA049_2784	COG1702	phosphate starvation-inducible protein PhoH
VAA049_2785	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VAA049_2786	COG4535	Mg2 and Co2 transporter CorC
VAA049_2787	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VAA049_2788	COG2888	peptidyl-tyrosine sulfation
VAA049_2789	COG0495	leucyl-tRNA aminoacylation
VAA049_2790	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VAA049_2791	COG1466	dna polymerase III delta subunit
VAA049_2792	COG0799	negative regulation of ribosome biogenesis
VAA049_2793	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VAA049_2794	COG0768	penicillin binding
VAA049_2795	COG0772	Belongs to the SEDS family
VAA049_2796	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VAA049_2797	COG1686	Belongs to the peptidase S11 family
VAA049_2799	COG2921	Belongs to the UPF0250 family
VAA049_28	COG1272	protein, Hemolysin III
VAA049_280	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VAA049_2800	COG0321	lipoyl(octanoyl) transferase activity
VAA049_2801	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VAA049_2803	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VAA049_2808	COG1596	polysaccharide export
VAA049_2810	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VAA049_2816	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
VAA049_2824	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VAA049_2825	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VAA049_2827	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VAA049_2833	COG0366	Alpha amylase catalytic
VAA049_2834	COG1263	PTS System
VAA049_2834	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VAA049_2835	COG1609	Transcriptional regulator
VAA049_2836	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VAA049_2837	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VAA049_2838	COG2011	ABC-type metal ion transport system permease component
VAA049_2839	COG1464	Belongs to the NlpA lipoprotein family
VAA049_284	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VAA049_2840	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VAA049_2842	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VAA049_2842	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VAA049_2844	COG3706	GGDEF domain
VAA049_2845	COG1611	Belongs to the LOG family
VAA049_2846	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VAA049_2848	COG0583	DNA-binding transcription factor activity
VAA049_2849	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VAA049_2849	COG0301	tRNA thio-modification
VAA049_285	COG3954	Phosphoribulokinase
VAA049_2851	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VAA049_2852	COG1722	exodeoxyribonuclease VII activity
VAA049_2853	COG0142	geranyltranstransferase activity
VAA049_2854	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VAA049_2855	COG0564	pseudouridine synthase activity
VAA049_2856	COG3098	single-species biofilm formation
VAA049_2858	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VAA049_2861	COG1671	Belongs to the UPF0178 family
VAA049_2862	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VAA049_2863	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VAA049_2864	COG0254	rRNA binding
VAA049_2865	COG1720	tRNA m6t6A37 methyltransferase activity
VAA049_2866	COG0442	prolyl-tRNA aminoacylation
VAA049_287	COG0429	hydrolase of the alpha beta-hydrolase fold
VAA049_2870	COG0047	phosphoribosylformylglycinamidine synthase activity
VAA049_2870	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VAA049_2871	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VAA049_2873	COG0590	tRNA wobble adenosine to inosine editing
VAA049_2874	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VAA049_2880	COG0484	heat shock protein binding
VAA049_2881	COG0443	Heat shock 70 kDa protein
VAA049_2882	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VAA049_2883	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VAA049_2884	COG0497	DNA recombination
VAA049_2885	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAA049_2886	COG2914	Belongs to the UPF0125 (RnfH) family
VAA049_2887	COG2867	negative regulation of translational initiation
VAA049_2888	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VAA049_2889	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VAA049_289	COG0488	(ABC) transporter
VAA049_2890	COG0732	type I restriction modification DNA specificity domain
VAA049_2891	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VAA049_2894	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VAA049_2895	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VAA049_2896	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VAA049_2898	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
VAA049_2899	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
VAA049_290	COG2249	NAD(P)H dehydrogenase (quinone) activity
VAA049_2900	COG3051	citrate lyase alpha subunit
VAA049_2901	COG2301	Belongs to the HpcH HpaI aldolase family
VAA049_2902	COG3052	prosthetic group binding
VAA049_2903	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
VAA049_2905	COG3630	sodium ion export across plasma membrane
VAA049_2906	COG5016	pyruvate
VAA049_2906	COG0511	ligase activity, forming carbon-carbon bonds
VAA049_2907	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VAA049_2909	COG4565	transcriptional regulatory protein
VAA049_2912	COG0583	DNA-binding transcription factor activity
VAA049_2913	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAA049_2914	COG1115	amino acid carrier protein
VAA049_2915	COG2015	COG2015, Alkyl sulfatase and related hydrolases
VAA049_2916	COG0583	DNA-binding transcription factor activity
VAA049_2918	COG1120	ATPase activity
VAA049_2919	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VAA049_2920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VAA049_2921	COG4592	Periplasmic binding protein
VAA049_2923	COG1028	Short-chain dehydrogenase reductase Sdr
VAA049_2924	COG1169	isochorismate synthase
VAA049_2925	COG1021	2,3-dihydroxybenzoate-AMP ligase
VAA049_2926	COG3433	isochorismatase activity
VAA049_2926	COG1535	isochorismatase
VAA049_2927	COG1584	GPR1 FUN34 yaaH family protein
VAA049_2929	COG0519	Catalyzes the synthesis of GMP from XMP
VAA049_2929	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VAA049_293	COG1047	Peptidyl-prolyl cis-trans
VAA049_2930	COG0517	IMP dehydrogenase activity
VAA049_2930	COG0516	GMP reductase activity
VAA049_2932	COG1570	exodeoxyribonuclease VII activity
VAA049_2934	COG1160	GTP binding
VAA049_2935	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAA049_2936	COG2976	Protein conserved in bacteria
VAA049_2937	COG0124	histidyl-tRNA synthetase
VAA049_2938	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VAA049_2941	COG0105	UTP biosynthetic process
VAA049_2942	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VAA049_2943	COG2975	iron-sulfur cluster assembly
VAA049_2944	COG0633	Ferredoxin
VAA049_2948	COG0822	iron-sulfur transferase activity
VAA049_2949	COG1104	cysteine desulfurase activity
VAA049_295	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VAA049_2950	COG1959	2 iron, 2 sulfur cluster binding
VAA049_2952	COG0483	inositol monophosphate 1-phosphatase activity
VAA049_2953	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VAA049_2954	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VAA049_2955	COG1862	Preprotein translocase
VAA049_2956	COG0343	queuine tRNA-ribosyltransferase activity
VAA049_2957	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VAA049_2958	COG0517	IMP dehydrogenase activity
VAA049_296	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VAA049_2960	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VAA049_2961	COG0583	DNA-binding transcription factor activity
VAA049_2962	COG0450	alkyl hydroperoxide reductase
VAA049_2963	COG3142	Participates in the control of copper homeostasis
VAA049_2966	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VAA049_2967	COG0581	inorganic phosphate transmembrane transporter activity
VAA049_2969	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VAA049_297	COG3083	sulfuric ester hydrolase activity
VAA049_2970	COG0248	Ppx GppA phosphatase
VAA049_2972	COG5002	protein histidine kinase activity
VAA049_2973	COG0745	RESPONSE REGULATOR receiver
VAA049_2974	COG2974	May be involved in recombination
VAA049_2976	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VAA049_298	COG0557	exoribonuclease II activity
VAA049_2984	COG0542	response to heat
VAA049_2986	COG0564	pseudouridine synthase activity
VAA049_2987	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAA049_2988	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VAA049_2989	COG0077	Prephenate dehydratase
VAA049_2989	COG1605	Chorismate mutase
VAA049_299	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VAA049_2990	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VAA049_2991	COG5001	Diguanylate cyclase
VAA049_2992	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VAA049_2993	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VAA049_2995	COG0488	(ABC) transporter
VAA049_2997	COG1605	Chorismate mutase
VAA049_2997	COG0287	Prephenate dehydrogenase
VAA049_2998	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VAA049_2999	COG3275	phosphorelay sensor kinase activity
VAA049_3	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VAA049_30	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VAA049_300	COG0051	transcription antitermination factor activity, RNA binding
VAA049_3000	COG3279	Response regulator of the LytR AlgR family
VAA049_3001	COG1472	Belongs to the glycosyl hydrolase 3 family
VAA049_3002	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VAA049_3003	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VAA049_3006	COG1966	Carbon starvation protein
VAA049_3007	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VAA049_3008	COG1047	Peptidyl-prolyl cis-trans
VAA049_3009	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VAA049_301	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VAA049_3010	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VAA049_3011	COG0196	riboflavin kinase activity
VAA049_3012	COG0728	peptidoglycan biosynthetic process
VAA049_3013	COG0268	Binds directly to 16S ribosomal RNA
VAA049_3014	COG0640	Transcriptional regulator
VAA049_3015	COG0583	DNA-binding transcription factor activity
VAA049_3016	COG1283	sodium-dependent phosphate transmembrane transporter activity
VAA049_3017	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VAA049_3018	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VAA049_3019	COG0730	response to heat
VAA049_302	COG0088	Forms part of the polypeptide exit tunnel
VAA049_3020	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
VAA049_3021	COG0494	nUDIX hydrolase
VAA049_3022	COG3066	DNA modification
VAA049_3023	COG0667	Aldo Keto reductase
VAA049_3025	COG2204	response regulator
VAA049_3026	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VAA049_3027	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VAA049_3029	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VAA049_303	COG0089	rRNA binding
VAA049_3030	COG0513	Belongs to the DEAD box helicase family
VAA049_3031	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VAA049_3035	COG3153	acetyltransferase
VAA049_304	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VAA049_3043	COG4785	May be involved in cell division
VAA049_3044	COG1185	polyribonucleotide nucleotidyltransferase activity
VAA049_3045	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VAA049_3046	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VAA049_3047	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VAA049_3048	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VAA049_3049	COG0195	Participates in both transcription termination and antitermination
VAA049_305	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VAA049_3050	COG0779	Required for maturation of 30S ribosomal subunits
VAA049_3053	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VAA049_3055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VAA049_3056	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VAA049_3057	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VAA049_3058	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VAA049_3059	COG1534	Rna-binding protein
VAA049_306	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VAA049_3060	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VAA049_3061	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VAA049_3062	COG2027	D-alanyl-D-alanine carboxypeptidase
VAA049_3063	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VAA049_3064	COG0739	heme binding
VAA049_3067	COG0316	Belongs to the HesB IscA family
VAA049_3068	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VAA049_307	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VAA049_3070	COG0628	permease
VAA049_3071	COG2813	Specifically methylates the guanine in position
VAA049_3073	COG0747	negative chemotaxis
VAA049_3074	COG0601	transmembrane transport
VAA049_3075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAA049_3076	COG0444	Belongs to the ABC transporter superfamily
VAA049_3077	COG4608	Belongs to the ABC transporter superfamily
VAA049_3079	COG2971	BadF BadG BcrA BcrD
VAA049_308	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VAA049_3083	COG3842	ATPase activity
VAA049_3085	COG1840	ABC-type Fe3 transport system, periplasmic component
VAA049_3086	COG0004	ammonium transporteR
VAA049_3087	COG0347	Belongs to the P(II) protein family
VAA049_3088	COG3112	Uncharacterised protein family (UPF0231)
VAA049_3089	COG1049	propionate catabolic process, 2-methylcitrate cycle
VAA049_309	COG0255	Belongs to the universal ribosomal protein uL29 family
VAA049_3091	COG1752	Esterase of the alpha-beta hydrolase superfamily
VAA049_3092	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VAA049_3093	COG1643	Atp-dependent helicase
VAA049_3095	COG1489	DNA binding
VAA049_3096	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VAA049_3097	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VAA049_3099	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VAA049_31	COG0569	domain protein
VAA049_310	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VAA049_3100	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VAA049_3101	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VAA049_3102	COG0842	Transport permease protein
VAA049_3103	COG1131	(ABC) transporter
VAA049_3104	COG0659	secondary active sulfate transmembrane transporter activity
VAA049_3105	COG0288	reversible hydration of carbon dioxide
VAA049_3108	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VAA049_3109	COG3107	peptidoglycan biosynthetic process
VAA049_311	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VAA049_3110	COG0792	nuclease activity
VAA049_3111	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VAA049_3112	COG2823	Periplasmic or secreted lipoprotein
VAA049_3113	COG2969	positive regulation of protein catabolic process
VAA049_3114	COG0625	glutathione transferase activity
VAA049_3115	COG2857	Cytochrome c1
VAA049_3116	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VAA049_3117	COG0723	plastoquinol--plastocyanin reductase activity
VAA049_3118	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VAA049_3119	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VAA049_312	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VAA049_3120	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VAA049_3122	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VAA049_3123	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VAA049_3124	COG0335	large ribosomal subunit rRNA binding
VAA049_3125	COG0336	Belongs to the RNA methyltransferase TrmD family
VAA049_3126	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VAA049_3127	COG0228	four-way junction DNA binding
VAA049_3128	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VAA049_313	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VAA049_3130	COG4137	Cytochrome C assembly protein
VAA049_3131	COG4536	flavin adenine dinucleotide binding
VAA049_3132	COG1854	S-ribosylhomocysteine lyase activity
VAA049_3133	COG2918	glutathione biosynthetic process
VAA049_3134	COG0612	Peptidase, M16
VAA049_3135	COG1238	metal cluster binding
VAA049_3137	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VAA049_3138	COG0511	ligase activity, forming carbon-carbon bonds
VAA049_3138	COG5016	pyruvate
VAA049_3139	COG3630	sodium ion export across plasma membrane
VAA049_314	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VAA049_3148	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
VAA049_3149	COG0527	aspartate kinase activity
VAA049_315	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VAA049_3150	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VAA049_3151	COG2137	regulation of response to DNA damage stimulus
VAA049_3152	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VAA049_3154	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
VAA049_3155	COG4208	sulfate ABC transporter
VAA049_3159	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VAA049_316	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VAA049_3160	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VAA049_3161	COG1388	LysM domain
VAA049_3161	COG4942	peptidase
VAA049_3162	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VAA049_3163	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VAA049_3164	COG0585	pseudouridine synthase activity
VAA049_3165	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VAA049_3166	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VAA049_3167	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VAA049_3168	COG1968	undecaprenyl-diphosphatase activity
VAA049_3169	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VAA049_317	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VAA049_3170	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VAA049_3171	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VAA049_3173	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VAA049_3174	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VAA049_3175	COG1610	YqeY-like protein
VAA049_3176	COG0358	DNA primase activity
VAA049_3177	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VAA049_318	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VAA049_3180	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VAA049_3181	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VAA049_3182	COG1349	DNA-binding transcription factor activity
VAA049_3183	COG0469	pyruvate kinase activity
VAA049_3186	COG0583	DNA-binding transcription factor activity
VAA049_3187	COG1279	arginine transmembrane transporter activity
VAA049_3188	COG0668	transmembrane transport
VAA049_3189	COG0191	fructose-bisphosphate aldolase activity
VAA049_319	COG1841	ribosomal large subunit assembly
VAA049_3190	COG0126	phosphoglycerate kinase activity
VAA049_3191	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VAA049_3192	COG4771	TonB-dependent receptor
VAA049_3193	COG0583	DNA-binding transcription factor activity
VAA049_3194	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VAA049_3195	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VAA049_3196	COG3091	SprT-like family
VAA049_3197	COG2356	endonuclease I
VAA049_3198	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VAA049_3199	COG0189	ligase activity
VAA049_32	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VAA049_32	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VAA049_320	COG0200	Binds to the 23S rRNA
VAA049_3200	COG1678	Uncharacterized ACR, COG1678
VAA049_3201	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VAA049_3202	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VAA049_3206	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VAA049_3207	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VAA049_3208	COG0762	integral membrane protein
VAA049_321	COG0201	protein transport
VAA049_3211	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VAA049_3212	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VAA049_3213	COG2066	Belongs to the glutaminase family
VAA049_3214	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VAA049_3215	COG1194	a g-specific adenine glycosylase
VAA049_3216	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VAA049_3217	COG0741	lytic transglycosylase activity
VAA049_3228	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VAA049_3229	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VAA049_323	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VAA049_3230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VAA049_3231	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VAA049_3232	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VAA049_3233	COG2967	ApaG domain
VAA049_3234	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VAA049_3236	COG3610	response to peptide
VAA049_3237	COG2966	Psort location CytoplasmicMembrane, score
VAA049_3238	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VAA049_3239	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VAA049_324	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VAA049_3240	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VAA049_3241	COG0142	geranyltranstransferase activity
VAA049_3242	COG0531	amino acid
VAA049_3243	COG0039	L-malate dehydrogenase activity
VAA049_3244	COG1438	arginine binding
VAA049_3247	COG0589	response to stress
VAA049_325	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VAA049_3252	COG2235	arginine
VAA049_3253	COG0312	modulator of DNA gyrase
VAA049_3254	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VAA049_3255	COG3164	Protein of unknown function
VAA049_3256	COG1530	ribonuclease E activity
VAA049_3257	COG0424	maF-like protein
VAA049_3258	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VAA049_3259	COG1792	Involved in formation and maintenance of cell shape
VAA049_326	COG0202	RNA polymerase activity
VAA049_3260	COG1077	Cell shape determining protein MreB Mrl
VAA049_3269	COG1459	type II secretion system
VAA049_327	COG0203	ribosomal protein L17
VAA049_3273	COG3409	Peptidoglycan-binding domain 1 protein
VAA049_3273	COG3267	Type II secretory pathway component ExeA
VAA049_3278	COG2199	diguanylate cyclase activity
VAA049_3278	COG2200	EAL domain
VAA049_3279	COG0629	single-stranded DNA binding
VAA049_3282	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VAA049_3284	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VAA049_3285	COG0527	aspartate kinase activity
VAA049_3286	COG1410	methionine synthase
VAA049_3286	COG0646	methionine synthase
VAA049_329	COG0545	Peptidyl-prolyl cis-trans isomerase
VAA049_33	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VAA049_330	COG0697	spore germination
VAA049_3301	COG0175	sulfate reduction
VAA049_3302	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VAA049_3303	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VAA049_3307	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VAA049_3308	COG0735	belongs to the Fur family
VAA049_331	COG3061	Opacity-associated protein A
VAA049_331	COG3266	domain, Protein
VAA049_3311	COG0166	Belongs to the GPI family
VAA049_3312	COG0432	Pfam Uncharacterised protein family UPF0047
VAA049_3313	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VAA049_3314	COG0305	Participates in initiation and elongation during chromosome replication
VAA049_3316	COG0359	binds to the 23S rRNA
VAA049_3317	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
VAA049_3318	COG2965	DNA replication, synthesis of RNA primer
VAA049_3319	COG0360	Binds together with S18 to 16S ribosomal RNA
VAA049_332	COG2153	protein acetylation
VAA049_3321	COG2906	2 iron, 2 sulfur cluster binding
VAA049_3322	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VAA049_3323	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VAA049_3324	COG0049	tRNA binding
VAA049_3325	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
VAA049_3327	COG2923	Belongs to the DsrF TusC family
VAA049_3328	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VAA049_3329	COG2964	Protein conserved in bacteria
VAA049_333	COG0513	Belongs to the DEAD box helicase family
VAA049_3330	COG0545	Peptidyl-prolyl cis-trans isomerase
VAA049_3332	COG2900	Belongs to the SlyX family
VAA049_3333	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VAA049_3334	COG0330	HflC and HflK could
VAA049_3335	COG0330	HflC and HflK could
VAA049_3336	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VAA049_3337	COG1923	regulation of RNA biosynthetic process
VAA049_3338	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VAA049_3339	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VAA049_3341	COG0802	atpase or kinase
VAA049_3342	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VAA049_335	COG0737	Belongs to the 5'-nucleotidase family
VAA049_3352	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VAA049_3353	COG1162	GTPase activity
VAA049_3354	COG0688	phosphatidylethanolamine metabolic process
VAA049_3355	COG0471	metal ion transport
VAA049_3357	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VAA049_3359	COG4942	peptidase
VAA049_336	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VAA049_336	COG1648	precorrin-2 dehydrogenase activity
VAA049_3361	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VAA049_3362	COG2816	NAD+ diphosphatase activity
VAA049_3363	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VAA049_3364	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VAA049_3365	COG0085	RNA polymerase activity
VAA049_3366	COG0222	ribosome binding
VAA049_3367	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VAA049_3368	COG0081	regulation of translation
VAA049_3369	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VAA049_337	COG0175	sulfate reduction
VAA049_3370	COG0250	Participates in transcription elongation, termination and antitermination
VAA049_3371	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VAA049_3372	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VAA049_3377	COG1072	(Pantothenic acid kinase))
VAA049_3379	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VAA049_338	COG2895	sulfate adenylyltransferase (ATP) activity
VAA049_3381	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAA049_339	COG0529	Catalyzes the synthesis of activated sulfate
VAA049_3390	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VAA049_3392	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
VAA049_3393	COG3118	belongs to the thioredoxin family
VAA049_3394	COG0513	Belongs to the DEAD box helicase family
VAA049_3395	COG0248	Ppx GppA phosphatase
VAA049_3396	COG0784	Response regulator, receiver
VAA049_3396	COG2205	protein histidine kinase activity
VAA049_3397	COG2814	Major facilitator Superfamily
VAA049_34	COG0242	peptide deformylase activity
VAA049_3400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VAA049_3401	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VAA049_3402	COG0511	ligase activity, forming carbon-carbon bonds
VAA049_3403	COG0439	Biotin carboxylase
VAA049_3404	COG2264	protein methyltransferase activity
VAA049_3405	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VAA049_3406	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VAA049_3408	COG1609	Transcriptional regulator
VAA049_3409	COG0129	dihydroxy-acid dehydratase activity
VAA049_3410	COG3265	gluconokinase activity
VAA049_3412	COG0800	Aldolase
VAA049_3415	COG0840	transmembrane signaling receptor activity
VAA049_3416	COG1982	Orn Lys Arg decarboxylase major
VAA049_3417	COG0531	amino acid
VAA049_3418	COG3710	Transcriptional regulator
VAA049_3419	COG0789	Transcriptional regulator
VAA049_3420	COG0138	bifunctional purine biosynthesis protein purh
VAA049_3421	COG0151	Belongs to the GarS family
VAA049_3423	COG0776	regulation of translation
VAA049_3424	COG1253	flavin adenine dinucleotide binding
VAA049_3425	COG1940	carbohydrate kinase activity
VAA049_3427	COG3068	Protein conserved in bacteria
VAA049_3429	COG1573	uracil-dna glycosylase
VAA049_343	COG1136	(ABC) transporter
VAA049_3430	COG0668	transmembrane transport
VAA049_3433	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VAA049_3434	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VAA049_3439	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VAA049_3440	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
VAA049_3442	COG0463	Glycosyl transferase, family 2
VAA049_3445	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VAA049_3446	COG0318	PFAM AMP-dependent synthetase and ligase
VAA049_3449	COG1028	Short-chain dehydrogenase reductase Sdr
VAA049_3451	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VAA049_3454	COG1088	dTDP-glucose 4,6-dehydratase activity
VAA049_346	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VAA049_3460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VAA049_3461	COG0662	Cupin 2, conserved barrel domain protein
VAA049_3461	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
VAA049_3462	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VAA049_3469	COG1519	Transferase
VAA049_347	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAA049_3475	COG3642	lipopolysaccharide core region biosynthetic process
VAA049_3476	COG0859	PFAM glycosyl transferase family 9
VAA049_3477	COG0463	Glycosyl transferase, family 2
VAA049_3478	COG0859	PFAM glycosyl transferase family 9
VAA049_3479	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VAA049_348	COG0729	surface antigen
VAA049_3480	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VAA049_3482	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VAA049_3483	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VAA049_3486	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VAA049_3487	COG1309	transcriptional regulator
VAA049_3488	COG1560	Kdo2-lipid A biosynthetic process
VAA049_3489	COG1560	Kdo2-lipid A biosynthetic process
VAA049_3490	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VAA049_3491	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VAA049_3492	COG1561	YicC-like family, N-terminal region
VAA049_3494	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VAA049_3494	COG1263	PTS System
VAA049_3495	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VAA049_3498	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VAA049_3499	COG1120	ATPase activity
VAA049_35	COG1652	LysM domain
VAA049_350	COG2105	PFAM AIG2 family protein
VAA049_3500	COG4774	siderophore transport
VAA049_3501	COG1132	(ABC) transporter
VAA049_3504	COG0514	ATP-dependent DNA helicase (RecQ)
VAA049_3505	COG2962	Rard protein
VAA049_3506	COG0405	Gamma-glutamyltransferase
VAA049_3508	COG1280	lysine exporter protein (LysE YggA)
VAA049_3509	COG0210	DNA helicase
VAA049_351	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VAA049_3511	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VAA049_3512	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VAA049_3514	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAA049_3516	COG0747	negative chemotaxis
VAA049_352	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VAA049_3525	COG1309	transcriptional regulator
VAA049_3526	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAA049_3527	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VAA049_3528	COG2960	long-chain fatty acid transporting porin activity
VAA049_3529	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VAA049_353	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VAA049_3530	COG0583	DNA-binding transcription factor activity
VAA049_354	COG0163	prenyltransferase activity
VAA049_3544	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
VAA049_3545	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VAA049_3546	COG1739	Uncharacterized protein family UPF0029
VAA049_3547	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAA049_3547	COG1024	Enoyl-CoA hydratase
VAA049_3548	COG0183	Belongs to the thiolase family
VAA049_3549	COG0583	DNA-binding transcription factor activity
VAA049_355	COG4143	(ABC) transporter
VAA049_3550	COG2814	Major facilitator Superfamily
VAA049_3552	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VAA049_3553	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VAA049_3554	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VAA049_3555	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VAA049_3556	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VAA049_3557	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VAA049_3559	COG0356	it plays a direct role in the translocation of protons across the membrane
VAA049_356	COG1178	ABC-type Fe3 transport system permease component
VAA049_3560	COG3312	ion transport
VAA049_3561	COG1475	DNA binding
VAA049_3562	COG1192	Involved in chromosome partitioning
VAA049_3563	COG0357	Ribosomal RNA small subunit methyltransferase G
VAA049_3564	COG0445	tRNA wobble uridine modification
VAA049_3565	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VAA049_3566	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VAA049_3567	COG0706	membrane insertase activity
VAA049_3568	COG0594	ribonuclease P activity
VAA049_3569	COG1126	abc transporter atp-binding protein
VAA049_357	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VAA049_358	COG3028	Belongs to the UPF0307 family
VAA049_359	COG0312	modulator of DNA gyrase
VAA049_36	COG0758	DNA mediated transformation
VAA049_360	COG2239	Acts as a magnesium transporter
VAA049_361	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAA049_363	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAA049_364	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VAA049_366	COG1137	ATPase activity
VAA049_367	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VAA049_37	COG2922	Belongs to the Smg family
VAA049_370	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VAA049_370	COG0517	IMP dehydrogenase activity
VAA049_372	COG1127	ABC transporter
VAA049_373	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VAA049_374	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VAA049_375	COG2854	intermembrane phospholipid transfer
VAA049_377	COG5007	Belongs to the BolA IbaG family
VAA049_378	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VAA049_379	COG0204	Acyl-transferase
VAA049_38	COG0551	DNA topoisomerase type I activity
VAA049_380	COG0251	oxidation-reduction process
VAA049_381	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VAA049_382	COG0540	Belongs to the ATCase OTCase family
VAA049_383	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VAA049_384	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VAA049_385	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VAA049_386	COG0564	pseudouridine synthase activity
VAA049_387	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VAA049_388	COG0525	valine-tRNA ligase activity
VAA049_389	COG2927	DNA polymerase III (CHI subunit)
VAA049_39	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VAA049_390	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VAA049_391	COG0795	lipopolysaccharide-transporting ATPase activity
VAA049_392	COG0795	lipopolysaccharide-transporting ATPase activity
VAA049_395	COG3437	response regulator, receiver
VAA049_4	COG0187	DNA topoisomerase II activity
VAA049_40	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VAA049_405	COG0066	3-isopropylmalate dehydratase activity
VAA049_406	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VAA049_407	COG0473	3-isopropylmalate dehydrogenase activity
VAA049_408	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VAA049_41	COG0009	L-threonylcarbamoyladenylate synthase
VAA049_412	COG0583	DNA-binding transcription factor activity
VAA049_413	COG1022	Amp-dependent synthetase and ligase
VAA049_414	COG0028	Belongs to the TPP enzyme family
VAA049_415	COG0440	acetolactate synthase activity
VAA049_416	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAA049_417	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VAA049_418	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VAA049_419	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VAA049_42	COG0408	coproporphyrinogen oxidase activity
VAA049_421	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAA049_422	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAA049_424	COG0354	folic acid binding
VAA049_425	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VAA049_427	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VAA049_428	COG1595	DNA-templated transcription, initiation
VAA049_43	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VAA049_430	COG3026	antisigma factor binding
VAA049_431	COG3086	response to oxidative stress
VAA049_432	COG0481	GTPase activity
VAA049_433	COG0681	Belongs to the peptidase S26 family
VAA049_434	COG0571	ribonuclease III activity
VAA049_435	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VAA049_436	COG1381	Involved in DNA repair and RecF pathway recombination
VAA049_437	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VAA049_438	COG0736	holo-[acyl-carrier-protein] synthase activity
VAA049_44	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VAA049_443	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VAA049_444	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VAA049_445	COG3956	TIGRFAM MazG family protein
VAA049_446	COG0504	CTP synthase activity
VAA049_447	COG0148	phosphopyruvate hydratase activity
VAA049_448	COG0617	tRNA 3'-terminal CCA addition
VAA049_449	COG3267	Type II secretory pathway component ExeA
VAA049_449	COG3409	Peptidoglycan-binding domain 1 protein
VAA049_451	COG4991	sh3 domain protein
VAA049_452	COG0306	phosphate transporter
VAA049_453	COG1392	Phosphate transport regulator
VAA049_454	COG3025	triphosphatase activity
VAA049_456	COG0840	transmembrane signaling receptor activity
VAA049_457	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VAA049_458	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VAA049_458	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VAA049_459	COG1538	Outer membrane efflux protein
VAA049_460	COG0494	nUDIX hydrolase
VAA049_461	COG3151	Protein conserved in bacteria
VAA049_463	COG3150	esterase
VAA049_464	COG0187	DNA topoisomerase II activity
VAA049_465	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VAA049_466	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VAA049_467	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VAA049_468	COG0237	dephospho-CoA kinase activity
VAA049_470	COG1459	type II secretion system
VAA049_471	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VAA049_475	COG0716	FMN binding
VAA049_476	COG4974	Belongs to the 'phage' integrase family
VAA049_477	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VAA049_478	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VAA049_479	COG0737	Belongs to the 5'-nucleotidase family
VAA049_480	COG2186	Transcriptional regulator
VAA049_481	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VAA049_482	COG0508	dehydrogenase complex catalyzes the overall conversion of
VAA049_483	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VAA049_484	COG0275	rRNA processing
VAA049_485	COG3116	cell division
VAA049_486	COG0768	penicillin binding
VAA049_487	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VAA049_488	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VAA049_489	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VAA049_490	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VAA049_491	COG0772	Belongs to the SEDS family
VAA049_492	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VAA049_493	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VAA049_494	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VAA049_495	COG0849	cell division
VAA049_496	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VAA049_497	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VAA049_499	COG0653	protein targeting
VAA049_500	COG0494	nUDIX hydrolase
VAA049_501	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VAA049_502	COG0505	Belongs to the CarA family
VAA049_503	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VAA049_507	COG0583	DNA-binding transcription factor activity
VAA049_508	COG0730	response to heat
VAA049_509	COG2860	membrane
VAA049_510	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VAA049_512	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VAA049_514	COG0493	'glutamate synthase
VAA049_515	COG0069	glutamate synthase activity
VAA049_515	COG0067	glutamate synthase
VAA049_515	COG0070	glutamate synthase
VAA049_517	COG0069	glutamate synthase activity
VAA049_517	COG0070	glutamate synthase
VAA049_517	COG0067	glutamate synthase
VAA049_518	COG1242	4 iron, 4 sulfur cluster binding
VAA049_519	COG4251	negative regulation of phosphorylation
VAA049_519	COG5001	Diguanylate cyclase
VAA049_519	COG2203	Gaf domain
VAA049_519	COG3706	GGDEF domain
VAA049_52	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VAA049_520	COG5002	protein histidine kinase activity
VAA049_520	COG2198	Histidine kinase
VAA049_520	COG0784	Response regulator, receiver
VAA049_521	COG0745	RESPONSE REGULATOR receiver
VAA049_524	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VAA049_526	COG0083	homoserine kinase activity
VAA049_527	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VAA049_528	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VAA049_529	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VAA049_53	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VAA049_530	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VAA049_533	COG1115	amino acid carrier protein
VAA049_536	COG0084	hydrolase, TatD family'
VAA049_537	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VAA049_538	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VAA049_539	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VAA049_540	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VAA049_541	COG0813	purine-nucleoside phosphorylase activity
VAA049_543	COG0560	Phosphoserine phosphatase
VAA049_545	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VAA049_546	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VAA049_547	COG1022	Amp-dependent synthetase and ligase
VAA049_55	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VAA049_550	COG3250	beta-galactosidase activity
VAA049_551	COG1609	Transcriptional regulator
VAA049_553	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VAA049_555	COG0189	ligase activity
VAA049_555	COG0569	domain protein
VAA049_557	COG0456	acetyltransferase
VAA049_559	COG2171	N-acyltransferase activity
VAA049_56	COG2104	thiamine diphosphate biosynthetic process
VAA049_560	COG3141	response to X-ray
VAA049_563	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VAA049_565	COG1074	ATP-dependent DNA helicase activity
VAA049_566	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VAA049_568	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VAA049_568	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VAA049_57	COG2022	thiamine diphosphate biosynthetic process
VAA049_570	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VAA049_571	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VAA049_572	COG2166	iron-sulfur cluster assembly
VAA049_573	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VAA049_574	COG0693	protein deglycase activity
VAA049_575	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VAA049_576	COG3248	Nucleoside-binding outer membrane protein
VAA049_578	COG1595	DNA-templated transcription, initiation
VAA049_58	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VAA049_580	COG2211	Major facilitator Superfamily
VAA049_581	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VAA049_583	COG2813	Specifically methylates the guanine in position
VAA049_584	COG0271	Belongs to the BolA IbaG family
VAA049_585	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VAA049_586	COG1805	sodium ion transport
VAA049_587	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VAA049_588	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VAA049_589	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VAA049_59	COG0006	proline dipeptidase activity
VAA049_59	COG0006	proline dipeptidase activity
VAA049_590	COG2871	sodium ion transport
VAA049_591	COG1477	protein flavinylation
VAA049_593	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VAA049_595	COG3706	GGDEF domain
VAA049_596	COG0733	neurotransmitter:sodium symporter activity
VAA049_598	COG0189	ligase activity
VAA049_599	COG0189	ligase activity
VAA049_599	COG4067	protein conserved in archaea
VAA049_600	COG2195	Cleaves the N-terminal amino acid of tripeptides
VAA049_601	COG2252	PERMEase
VAA049_602	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VAA049_605	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VAA049_606	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VAA049_607	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VAA049_608	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VAA049_608	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VAA049_611	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VAA049_612	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VAA049_613	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VAA049_614	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VAA049_616	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VAA049_617	COG0024	Methionine aminopeptidase
VAA049_618	COG0052	Belongs to the universal ribosomal protein uS2 family
VAA049_619	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VAA049_620	COG0528	UMP kinase activity
VAA049_621	COG0233	cytoplasmic translational termination
VAA049_622	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VAA049_623	COG0575	Belongs to the CDS family
VAA049_624	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VAA049_625	COG0750	zinc metalloprotease
VAA049_627	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VAA049_628	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VAA049_629	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VAA049_63	COG1522	sequence-specific DNA binding
VAA049_630	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VAA049_631	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VAA049_632	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VAA049_633	COG0587	DNA-directed DNA polymerase activity
VAA049_634	COG0825	malonyl-CoA metabolic process
VAA049_635	COG0037	tRNA processing
VAA049_637	COG3479	Phenolic acid decarboxylase
VAA049_638	COG0347	Belongs to the P(II) protein family
VAA049_64	COG5002	protein histidine kinase activity
VAA049_64	COG5001	Diguanylate cyclase
VAA049_640	COG1388	LysM domain
VAA049_640	COG0741	lytic transglycosylase activity
VAA049_641	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VAA049_642	COG2226	methyltransferase
VAA049_643	COG0328	RNA-DNA hybrid ribonuclease activity
VAA049_644	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VAA049_646	COG1960	acyl-CoA dehydrogenase activity
VAA049_647	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VAA049_648	COG0121	glutamine amidotransferase
VAA049_649	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VAA049_65	COG0742	ribosomal rna small subunit methyltransferase
VAA049_650	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VAA049_651	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VAA049_652	COG3706	GGDEF domain
VAA049_653	COG1187	pseudouridine synthase activity
VAA049_654	COG2840	Smr protein MutS2
VAA049_661	COG2217	Heavy metal translocating P-type atpase
VAA049_661	COG2608	mercury ion transmembrane transporter activity
VAA049_662	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VAA049_665	COG1629	transport
VAA049_665	COG4774	siderophore transport
VAA049_666	COG2375	cellular response to nickel ion
VAA049_667	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VAA049_667	COG2226	methyltransferase
VAA049_667	COG3433	isochorismatase activity
VAA049_67	COG0697	spore germination
VAA049_674	COG0784	Response regulator, receiver
VAA049_674	COG0835	chemotaxis
VAA049_675	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VAA049_676	COG1815	bacterial-type flagellum-dependent cell motility
VAA049_677	COG1558	bacterial-type flagellum-dependent cell motility
VAA049_678	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
VAA049_679	COG1749	Flagellar hook protein flgE
VAA049_68	COG0589	response to stress
VAA049_680	COG4787	bacterial-type flagellum-dependent cell motility
VAA049_681	COG4786	Flagellar basal body rod
VAA049_682	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VAA049_683	COG1706	bacterial-type flagellum-dependent cell motility
VAA049_684	COG3951	Flagellar rod assembly protein muramidase FlgJ
VAA049_684	COG1705	Flagellar rod assembly protein muramidase FlgJ
VAA049_687	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VAA049_688	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VAA049_69	COG1528	Iron-storage protein
VAA049_7	COG0071	Belongs to the small heat shock protein (HSP20) family
VAA049_707	COG0012	GTP binding
VAA049_708	COG0193	aminoacyl-tRNA hydrolase activity
VAA049_709	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VAA049_710	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VAA049_711	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
VAA049_712	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VAA049_713	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VAA049_714	COG2890	protein-(glutamine-N5) methyltransferase activity
VAA049_715	COG3094	Invasion gene expression up-regulator, SirB
VAA049_716	COG2912	Transglutaminase-like superfamily
VAA049_717	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VAA049_718	COG0737	Belongs to the 5'-nucleotidase family
VAA049_719	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VAA049_72	COG2081	HI0933 family
VAA049_720	COG2233	PERMEase
VAA049_724	COG1393	Belongs to the ArsC family
VAA049_725	COG4783	chaperone-mediated protein folding
VAA049_729	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VAA049_73	COG1322	Protein conserved in bacteria
VAA049_731	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VAA049_732	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VAA049_734	COG1876	peptidase activity
VAA049_735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VAA049_736	COG1393	Belongs to the ArsC family
VAA049_74	COG2226	methyltransferase
VAA049_740	COG2837	iron assimilation
VAA049_741	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VAA049_742	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VAA049_743	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VAA049_744	COG1334	flagellar protein FlaG
VAA049_745	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VAA049_747	COG1516	flagellar protein fliS
VAA049_748	COG2204	response regulator
VAA049_749	COG4191	Histidine kinase
VAA049_750	COG2204	response regulator
VAA049_751	COG1677	Flagellar hook-basal body complex protein FliE
VAA049_753	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VAA049_754	COG1317	bacterial-type flagellum organization
VAA049_758	COG1580	Controls the rotational direction of flagella during chemotaxis
VAA049_76	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VAA049_763	COG1987	bacterial-type flagellum assembly
VAA049_764	COG1684	flagellar biosynthetic protein fliR
VAA049_767	COG2890	protein-(glutamine-N5) methyltransferase activity
VAA049_768	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VAA049_769	COG2860	membrane
VAA049_77	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VAA049_770	COG3101	peptidyl-lysine hydroxylation
VAA049_772	COG0431	NADPH-dependent FMN reductase
VAA049_773	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VAA049_773	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAA049_774	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VAA049_775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAA049_776	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VAA049_777	COG0735	belongs to the Fur family
VAA049_779	COG0583	DNA-binding transcription factor activity
VAA049_78	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VAA049_781	COG1346	cytolysis
VAA049_784	COG0596	Alpha beta hydrolase
VAA049_785	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VAA049_786	COG0033	Phosphoglucomutase
VAA049_788	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VAA049_789	COG0372	Belongs to the citrate synthase family
VAA049_79	COG0805	protein transport
VAA049_790	COG2009	succinate dehydrogenase
VAA049_791	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VAA049_792	COG1053	succinate dehydrogenase
VAA049_794	COG0567	Dehydrogenase, E1 component
VAA049_795	COG0508	dehydrogenase complex catalyzes the overall conversion of
VAA049_796	COG0045	succinate-CoA ligase (ADP-forming) activity
VAA049_798	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VAA049_799	COG1121	(ABC) transporter
VAA049_8	COG3977	Valine--pyruvate aminotransferase
VAA049_80	COG1858	cytochrome C peroxidase
VAA049_800	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VAA049_801	COG4977	sequence-specific DNA binding
VAA049_802	COG1918	ferrous iron import across plasma membrane
VAA049_806	COG0018	arginyl-trna synthetase
VAA049_807	COG1025	Belongs to the peptidase M16 family
VAA049_809	COG2062	phosphohistidine phosphatase, SixA
VAA049_81	COG0534	Mate efflux family protein
VAA049_812	COG0455	bacterial-type flagellum organization
VAA049_815	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VAA049_816	COG0643	Histidine kinase
VAA049_816	COG2198	Histidine kinase
VAA049_817	COG2201	protein-glutamate methylesterase activity
VAA049_818	COG1192	Involved in chromosome partitioning
VAA049_820	COG0835	chemotaxis
VAA049_822	COG4133	protoheme IX ABC transporter activity
VAA049_823	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VAA049_824	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VAA049_826	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VAA049_827	COG1138	Cytochrome C-type biogenesis protein
VAA049_828	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VAA049_829	COG4235	cytochrome complex assembly
VAA049_829	COG3088	subunit of a heme lyase
VAA049_83	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VAA049_831	COG2853	Lipoprotein
VAA049_835	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VAA049_836	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VAA049_837	COG0123	including yeast histone deacetylase and acetoin utilization protein
VAA049_84	COG2937	Belongs to the GPAT DAPAT family
VAA049_840	COG3083	sulfuric ester hydrolase activity
VAA049_842	COG3081	Nucleoid-associated protein
VAA049_844	COG1757	Na H antiporter
VAA049_845	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VAA049_846	COG2095	MarC family integral membrane protein
VAA049_847	COG1012	belongs to the aldehyde dehydrogenase family
VAA049_847	COG1454	alcohol dehydrogenase
VAA049_849	COG0659	secondary active sulfate transmembrane transporter activity
VAA049_85	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VAA049_850	COG1530	ribonuclease E activity
VAA049_851	COG0564	pseudouridine synthase activity
VAA049_852	COG0424	maF-like protein
VAA049_853	COG1399	metal-binding, possibly nucleic acid-binding protein
VAA049_854	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VAA049_855	COG0416	fatty acid biosynthetic process
VAA049_856	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VAA049_857	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
VAA049_858	COG1028	Short-chain dehydrogenase reductase Sdr
VAA049_859	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VAA049_86	COG3161	chorismate lyase activity
VAA049_860	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VAA049_861	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VAA049_862	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VAA049_863	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VAA049_865	COG0084	hydrolase, TatD family'
VAA049_866	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VAA049_866	COG1263	PTS System
VAA049_868	COG0733	neurotransmitter:sodium symporter activity
VAA049_87	COG1580	Controls the rotational direction of flagella during chemotaxis
VAA049_871	COG4667	esterase of the alpha-beta hydrolase superfamily
VAA049_873	COG1940	carbohydrate kinase activity
VAA049_874	COG0784	Response regulator, receiver
VAA049_874	COG0835	chemotaxis
VAA049_877	COG2226	methyltransferase
VAA049_879	COG0676	glucose-6-phosphate 1-epimerase activity
VAA049_88	COG0840	transmembrane signaling receptor activity
VAA049_880	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VAA049_881	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAA049_883	COG3139	Protein of unknown function (DUF1315)
VAA049_884	COG0252	asparaginase activity
VAA049_885	COG0616	signal peptide processing
VAA049_886	COG1902	pentaerythritol trinitrate reductase activity
VAA049_886	COG0446	pyridine nucleotide-disulphide oxidoreductase
VAA049_887	COG0788	formyltetrahydrofolate deformylase activity
VAA049_889	COG1199	ATP-dependent helicase activity
VAA049_890	COG1214	PFAM Peptidase M22, glycoprotease
VAA049_893	COG0596	Alpha beta hydrolase
VAA049_896	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VAA049_899	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VAA049_9	COG0751	glycine-tRNA ligase activity
VAA049_90	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VAA049_901	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VAA049_902	COG0436	Aminotransferase
VAA049_903	COG1169	isochorismate synthase
VAA049_904	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VAA049_905	COG0596	Alpha beta hydrolase
VAA049_907	COG1441	menaquinone biosynthetic process
VAA049_909	COG3135	benzoate transporter
VAA049_91	COG0084	hydrolase, TatD family'
VAA049_910	COG1396	sequence-specific DNA binding
VAA049_911	COG0840	transmembrane signaling receptor activity
VAA049_917	COG3015	lipoprotein NlpE involved in copper resistance
VAA049_918	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VAA049_919	COG2894	cell division
VAA049_920	COG0850	regulation of cytokinetic process
VAA049_921	COG3100	YcgL domain-containing protein
VAA049_922	COG2951	lytic endotransglycosylase activity
VAA049_924	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VAA049_926	COG3005	denitrification pathway
VAA049_927	COG0243	molybdopterin cofactor binding
VAA049_931	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAA049_933	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VAA049_94	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VAA049_94	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VAA049_941	COG4589	Belongs to the CDS family
VAA049_943	COG5001	Diguanylate cyclase
VAA049_943	COG3300	MHYT domain
VAA049_946	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VAA049_947	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAA049_948	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VAA049_949	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VAA049_95	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VAA049_951	COG4191	Histidine kinase
VAA049_952	COG0544	peptidyl-prolyl cis-trans isomerase activity
VAA049_954	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VAA049_955	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VAA049_956	COG0776	regulation of translation
VAA049_957	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VAA049_958	COG1555	photosystem II stabilization
VAA049_959	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VAA049_960	COG0539	negative regulation of cytoplasmic translation
VAA049_961	COG0776	regulation of translation
VAA049_962	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VAA049_963	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VAA049_964	COG0284	orotidine-5'-phosphate decarboxylase activity
VAA049_967	COG0583	DNA-binding transcription factor activity
VAA049_969	COG0686	Belongs to the AlaDH PNT family
VAA049_971	COG1674	ftsk spoiiie
VAA049_972	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VAA049_973	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VAA049_974	COG2186	Transcriptional regulator
VAA049_977	COG0537	adenosine 5'-monophosphoramidase activity
VAA049_98	COG3078	GTPase activator activity
VAA049_983	COG1252	NADH dehydrogenase
VAA049_987	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VAA049_989	COG4591	ABC-type transport system involved in lipoprotein release permease component
VAA049_990	COG1136	(ABC) transporter
VAA049_991	COG4591	ABC-type transport system involved in lipoprotein release permease component
VAA049_993	COG2333	competence protein COMEC
VAA049_993	COG0658	competence protein
VAA049_994	COG1132	(ABC) transporter
VAA049_995	COG1663	tetraacyldisaccharide 4'-kinase activity
VAA049_997	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VAA049_998	COG2719	SpoVR family
VAA049_999	COG2718	Belongs to the UPF0229 family