locus-tag class description EN18_00015 ENOG4105XJC Two component transcriptional regulator (Winged helix family EN18_00020 ENOG4105BZU Histidine kinase EN18_00050 ENOG4107QVI Methyltransferase, type 11 EN18_00065 ENOG4105C2C drug resistance transporter, Bcr CflA EN18_00070 ENOG4105C8Q Methyl-accepting chemotaxis EN18_00080 ENOG4105DZ1 carboxypeptidase EN18_00100 ENOG4108RS6 transposase EN18_00105 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor EN18_00110 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) EN18_00115 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) EN18_00125 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) EN18_00135 ENOG4105F2I Transposase EN18_00160 ENOG4105C22 threonyL-tRNA synthetase EN18_00165 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) EN18_00170 ENOG41082NX 50s ribosomal protein l35 EN18_00175 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) EN18_00210 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EN18_00250 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein EN18_00280 ENOG4105D9U N-acetyltransferase EN18_00285 ENOG4105QNF Outer membrane lipoprotein EN18_00315 ENOG4105VXN addiction module toxin, RelE StbE family EN18_00325 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase EN18_00380 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A EN18_00395 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase EN18_00425 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase EN18_00440 ENOG4105QNF Outer membrane lipoprotein EN18_00455 ENOG4105YGK Pfam:UPF0157 EN18_00460 ENOG4105N14 lysine exporter protein LysE YggA EN18_00625 ENOG41080ET plasmid maintenance system killer protein EN18_00630 ENOG4105VDM plasmid maintenance system antidote protein, xre family EN18_00645 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A EN18_00665 ENOG4105QNF Outer membrane lipoprotein EN18_00760 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase EN18_00775 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system EN18_00780 ENOG4105W08 virulence gene repressor rsal EN18_00795 ENOG4105F2I Transposase EN18_00815 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase EN18_00900 ENOG4108RS6 transposase EN18_00960 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase EN18_00985 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase EN18_00990 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) EN18_00995 ENOG4105CGF Aromatic amino acid aminotransferase EN18_01000 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) EN18_01005 ENOG4105DM4 PTS System EN18_01010 ENOG4105DE4 1-phosphofructokinase EN18_01015 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein EN18_01020 ENOG4107B7Y DNA-binding transcriptional regulator FruR EN18_01025 ENOG4107RFY SbcCD D subunit EN18_01030 ENOG4105EYH Exonuclease EN18_01035 ENOG4108MGY Histidine kinase EN18_01040 ENOG4107KBT 8-Amino-7-oxononanoate synthase EN18_01050 ENOG4105CMQ Chloride channel EN18_01055 ENOG4105CKI cobalamin synthesis protein EN18_01060 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) EN18_01065 ENOG4105DFH Transport of potassium into the cell (By similarity) EN18_01070 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) EN18_01075 ENOG4105C08 Histidine kinase EN18_01080 ENOG4105EEX Two component transcriptional regulator (Winged helix family EN18_01085 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) EN18_01090 ENOG4108RHM integral membrane protein EN18_01100 ENOG4105EPM Diguanylate phosphodiesterase EN18_01110 ENOG4105DS1 cytochrome b561 EN18_01120 ENOG4105TMB Formate nitrite transporter EN18_01130 ENOG4105DUM transcriptional regulator, lysR family EN18_01135 ENOG4108UQ5 membrane protein YcdZ EN18_01140 ENOG4105CPB ATP-dependent endonuclease of the OLD family EN18_01145 ENOG4105CGH 5'-nucleotidase EN18_01150 ENOG4105DU1 integral membrane protein, terc EN18_01160 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA EN18_01195 ENOG4105BZU Histidine kinase EN18_01205 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) EN18_01215 ENOG4105BZU Histidine kinase EN18_01230 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) EN18_01235 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) EN18_01245 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EN18_01270 ENOG4108ZJT translation initiation factor, Sui1 EN18_01280 ENOG4105CPF Cell wall formation (By similarity) EN18_01290 ENOG4105CD5 CoA-binding domain protein EN18_01295 ENOG4105CWB LysR family transcriptional Regulator EN18_01315 ENOG4105KA0 thioesterase Superfamily protein EN18_01335 ENOG4105CYM Glutathione S-transferase EN18_01350 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) EN18_01355 ENOG4108JQ5 ABC transporter EN18_01360 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component EN18_01365 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component EN18_01370 ENOG4105E43 Extracellular solute-binding protein, family 5 EN18_01395 ENOG4105DUX Transporter EN18_01410 ENOG4107RCV ABC transporter, permease EN18_01425 ENOG4107STF Involved in phosphonate degradation (By similarity) EN18_01430 ENOG4108JPW Aminotransferase EN18_01435 ENOG4108KAZ Involved in phosphonate degradation (By similarity) EN18_01440 ENOG4105NXH GreA GreB family elongation factor EN18_01445 ENOG4105PAD Hydrolase EN18_01455 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain EN18_01460 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) EN18_01465 ENOG4105CKU formyltetrahydrofolate synthetase EN18_01470 ENOG4105E0X reductase EN18_01475 ENOG4105EUJ GTP cyclohydrolase i EN18_01480 ENOG4105CVM Molybdenum cofactor synthesis domain protein EN18_01485 ENOG4105D06 uba thif-type nad fad binding protein EN18_01495 ENOG4105KHC sulfurtransferase EN18_01500 ENOG4107RHR regulatoR EN18_01510 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) EN18_01515 ENOG4105CV1 Transketolase (EC 2.2.1.1) EN18_01540 ENOG4108M3J Dehydrogenase EN18_01555 ENOG4105RA2 Membrane EN18_01565 ENOG4105ETT transcriptional Regulator, LysR family EN18_01570 ENOG41067V3 Antibiotic biosynthesis monooxygenase EN18_01600 ENOG41080HT Transcriptional regulator, arsr family EN18_01610 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase EN18_01655 ENOG4105C5Y PTS System EN18_01660 ENOG4105ETE Transcriptional regulator (LacI family EN18_01665 ENOG4107R3K hydrolase EN18_01670 ENOG4105D7K pfkb domain protein EN18_01675 ENOG4105C6V Glycerol-3-phosphate dehydrogenase EN18_01680 ENOG4108NVR Methyl-accepting chemotaxis EN18_01685 ENOG4108ZG0 Ompa motb domain protein EN18_01690 ENOG4108V1T peptidylprolyl cis-trans isomerase EN18_01695 ENOG4107VXZ Hydrolase EN18_01700 ENOG4108N3W hemolysin secretion protein EN18_01705 ENOG4105CEE C4-dicarboxylate transporter EN18_01710 ENOG4105EJQ L-serine dehydratase EN18_01730 ENOG4105ETE Transcriptional regulator (LacI family EN18_01735 ENOG4105WH1 Two component transcriptional regulator luxr family EN18_01740 ENOG4105BZU Histidine kinase EN18_01755 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) EN18_01775 ENOG4105DHT Metal Dependent Phosphohydrolase EN18_01780 ENOG4108KX4 response regulator EN18_01785 ENOG4105BZU Histidine kinase EN18_01790 ENOG4105CXY transporter EN18_01795 ENOG4105C4Y ABC transporter EN18_01800 ENOG4107RCV ABC transporter, permease EN18_01805 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EN18_01810 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class EN18_01820 ENOG4105CHU acetyl-coa acetyltransferase EN18_01830 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EN18_01835 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EN18_01850 ENOG4105BZU Histidine kinase EN18_01855 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) EN18_01865 ENOG4108I6A alcohol dehydrogenase EN18_01875 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta EN18_01885 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC EN18_01890 ENOG4105CXY transporter EN18_01895 ENOG4105CA9 Pyruvate kinase EN18_01900 ENOG4105BZU Histidine kinase EN18_01905 ENOG4108SV3 Tmao reductase system periplasmic protein tort EN18_01910 ENOG4108Z5K methylglyoxal synthase EN18_01915 ENOG4108RWI nicotinamidase EN18_01920 ENOG41080IJ Diacylglycerol kinase EN18_01935 ENOG41088T4 Helicase IV EN18_01940 ENOG4105EM2 membrane EN18_01970 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) EN18_01975 ENOG4105E0C molybdate abc transporter EN18_01980 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein EN18_01985 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) EN18_02030 ENOG4105BZU Histidine kinase EN18_02035 ENOG4108QGH periplasmic EN18_02075 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) EN18_02080 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) EN18_02085 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A EN18_02090 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B EN18_02095 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) EN18_02100 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) EN18_02105 ENOG4105K63 Thioredoxin EN18_02135 ENOG4105DUM transcriptional regulator, lysR family EN18_02140 ENOG4105DMR ABC, transporter EN18_02145 ENOG4105GBT ABC transporter EN18_02150 ENOG4106PMH Extracellular solute-binding protein family 3 EN18_02155 ENOG4105E5Z arginine transporter ATP-binding subunit EN18_02165 ENOG4105EV2 VWA domain protein interacting with AAA ATPase EN18_02175 ENOG4108YZ4 nudix hydrolase EN18_02180 ENOG4105C5W Aldolase EN18_02185 ENOG4106RE7 Cytochrome EN18_02190 ENOG4108IG5 Transcriptional regulator EN18_02195 ENOG4105C1J atp-dependent rna helicase EN18_02200 ENOG4108ZYK Acyl carrier protein phosphodiesterase EN18_02210 ENOG4105E0U tyrosine-specific transport protein EN18_02215 ENOG4108N3W hemolysin secretion protein EN18_02220 ENOG4105CMR udp-glucose 4-epimerase EN18_02225 ENOG4105E7W lamb ycsf family protein EN18_02235 ENOG4107R7A Allophanate hydrolase subunit 2 EN18_02245 ENOG4105C6Y Udp-glucose 6-dehydrogenase EN18_02250 ENOG4105CV6 ABC transporter, permease EN18_02255 ENOG4108I0Y (ABC) transporter EN18_02265 ENOG4105RKW reductase (By EN18_02285 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) EN18_02330 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) EN18_02345 ENOG4107RE1 Inosine-guanosine kinase EN18_02350 ENOG4105E0M Sulfatase EN18_02360 ENOG4105C1J atp-dependent rna helicase EN18_02365 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) EN18_02375 ENOG4105CVA phosphate EN18_02385 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein EN18_02390 ENOG4108M1A Chitin-binding protein EN18_02395 ENOG4105D4Y metalloprotease EN18_02405 ENOG4105CYW agmatinase EN18_02410 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) EN18_02420 ENOG4105CJW magnesium transporter EN18_02425 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) EN18_02430 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) EN18_02440 ENOG4105CZK Aspartate kinase EN18_02445 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) EN18_02450 ENOG4108JPW Aminotransferase EN18_02455 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase EN18_02460 ENOG41090A4 Pterin carbinolamine dehydratase EN18_02465 ENOG4105MIR Phenylalanine 4-monooxygenase EN18_02470 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EN18_02485 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) EN18_02490 ENOG4105EGI Transcriptional regulator EN18_02505 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) EN18_02510 ENOG4105C37 (CBS) domain EN18_02515 ENOG4108UKZ OsmC family EN18_02520 ENOG4107YWA deoxycytidylate deaminase EN18_02540 ENOG4105DVH amino acid EN18_02545 ENOG4106TD9 Diguanylate cyclase EN18_02555 ENOG4108VAC response regulator EN18_02560 ENOG4108HRK Histidine kinase EN18_02575 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EN18_02580 ENOG4105C19 ABC transporter EN18_02595 ENOG4107RGM aldo keto reductase EN18_02600 ENOG4107T9C Alpha amylase catalytic region EN18_02615 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation EN18_02620 ENOG4108M0H Extracellular lipase EN18_02625 ENOG4107SDU Methyl-accepting chemotaxis EN18_02630 ENOG4105D4Y metalloprotease EN18_02635 ENOG4105EIF outer membrane protein W EN18_02645 ENOG41061WM D-Alanyl-D-Alanine EN18_02650 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EN18_02655 ENOG4105C4M (Ubiquinol oxidase) subunit I EN18_02660 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EN18_02670 ENOG4105BZC d-serine deaminase EN18_02675 ENOG4105W8I Transcriptional regulator EN18_02715 ENOG4105CPQ Dehydrogenase EN18_02720 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EN18_02725 ENOG4105TMR Functions as a holding molecular chaperone (holdase) which stabilizes unfolding intermediates and rapidly releases them in an active form once stress has abated. Plays an important role in protecting cells from severe heat shock and starvation, as well as in acid resistance of stationary-phase cells. It catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step (By similarity) EN18_02730 ENOG4105TMR Functions as a holding molecular chaperone (holdase) which stabilizes unfolding intermediates and rapidly releases them in an active form once stress has abated. Plays an important role in protecting cells from severe heat shock and starvation, as well as in acid resistance of stationary-phase cells. It catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step (By similarity) EN18_02740 ENOG4105EXG Transcriptional regulator EN18_02745 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase EN18_02765 ENOG4107SSZ Phosphatase EN18_02770 ENOG4105DHT Metal Dependent Phosphohydrolase EN18_02775 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase EN18_02780 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) EN18_02785 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) EN18_02810 ENOG4105BZW Glycerate kinase EN18_02815 ENOG4105C6Z Gluconate EN18_02820 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR EN18_02825 ENOG4108NVR Methyl-accepting chemotaxis EN18_02830 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related EN18_02835 ENOG41090JE Utilization Protein EN18_02840 ENOG4105D4P Coproporphyrinogen iii oxidase EN18_02845 ENOG4105WQ5 TonB family EN18_02850 ENOG41090AP transport protein EN18_02855 ENOG4106GFD transport protein EN18_02860 ENOG4107R4I Periplasmic binding protein EN18_02865 ENOG4105EHG Permease protein EN18_02870 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) EN18_02900 ENOG4105C8Q Methyl-accepting chemotaxis EN18_02905 ENOG4105QVC MOSC domain-containing protein EN18_02905 ENOG4105QVC MOSC domain-containing protein EN18_02910 ENOG4105EKE dihydroorotase EN18_02920 ENOG4105KAF membrAne EN18_02930 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) EN18_02935 ENOG4105CKW Inner membrane protein yedI EN18_02940 ENOG4108ESY Metal dependent phosphohydrolase EN18_02945 ENOG4105VEQ Cold shock protein EN18_02960 ENOG4105EQD regulatoR EN18_02970 ENOG4105BZU Histidine kinase EN18_02975 ENOG4105E98 transcriptional regulator DeoR family EN18_02990 ENOG4105EG2 ABC transporter, permease EN18_02995 ENOG4105D56 permease protein EN18_03000 ENOG4107FKK extracellular solute-binding protein family 1 EN18_03005 ENOG4108IJ9 (ABC) transporter EN18_03010 ENOG4108HK0 -acetyltransferase EN18_03025 ENOG4105K8R UPF0145 protein EN18_03030 ENOG41086KC Transcriptional regulator EN18_03035 ENOG4105KQ5 peptidylprolyl cis-trans isomerase EN18_03040 ENOG4107R88 Chemotaxis protein (CheV) EN18_03045 ENOG4105K56 Transcriptional regulator EN18_03050 ENOG4106TD9 Diguanylate cyclase EN18_03065 ENOG4105BZU Histidine kinase EN18_03085 ENOG4105ETT transcriptional Regulator, LysR family EN18_03090 ENOG4108K0B C-di-gmp phosphodiesterase EN18_03105 ENOG4105EUB pirin domain protein EN18_03110 ENOG4105NBK UPF0345 protein EN18_03120 ENOG4105E5W Transporter EN18_03130 ENOG4105C8Q Methyl-accepting chemotaxis EN18_03135 ENOG4105DAN ATP-dependent protease EN18_03145 ENOG4108JQ5 ABC transporter EN18_03150 ENOG4105E89 ABC transporter EN18_03155 ENOG4107SDU Methyl-accepting chemotaxis EN18_03170 ENOG4105CC0 LysR family Transcriptional regulator EN18_03175 ENOG4105DAA L-lactate EN18_03180 ENOG4105DMF Dehydrogenase EN18_03190 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) EN18_03205 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor EN18_03215 ENOG4105C1J atp-dependent rna helicase EN18_03220 ENOG4105CR8 Transcriptional regulator EN18_03230 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EN18_03240 ENOG4105BZ1 (ABC) transporter EN18_03250 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EN18_03285 ENOG4105K56 Transcriptional regulator EN18_03290 ENOG4108ZHJ Organic hydroperoxide resistance protein EN18_03300 ENOG4108SXK Transporter Drug Metabolite Exporter family EN18_03305 ENOG4105VW4 glutaredoxin 3 EN18_03310 ENOG4108P2H Inner membrane protein YjiG EN18_03315 ENOG41074DU domain protein EN18_03320 ENOG4105DN9 Na H antiporter EN18_03330 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EN18_03335 ENOG4105D03 DNA-3-methyladenine glycosylase II EN18_03340 ENOG4108VGI doxx family EN18_03365 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) EN18_03375 ENOG4107W52 maltose operon periplasmic protein EN18_03380 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) EN18_03395 ENOG4108N3W hemolysin secretion protein EN18_03410 ENOG4105C8Q Methyl-accepting chemotaxis EN18_03420 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) EN18_03425 ENOG4105CDA abc transporter atp-binding protein EN18_03435 ENOG4106TNF Periplasmic binding protein EN18_03440 ENOG4105EZ7 amino acid ABC transporter EN18_03445 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain EN18_03455 ENOG4105DR5 peptidase EN18_03465 ENOG4105CTS PTS system mannitol-specific EN18_03470 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase EN18_03475 ENOG4105E61 Mannitol repressor protein EN18_03480 ENOG4105EP9 oxidoreductase EN18_03510 ENOG4108RYK Nad-dependent epimerase dehydratase EN18_03515 ENOG4105JQN Transcriptional regulator EN18_03520 ENOG41069D7 Methyl-accepting chemotaxis EN18_03525 ENOG4105EMU Dehydrogenase EN18_03530 ENOG4105JQN Transcriptional regulator EN18_03540 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) EN18_03550 ENOG4105D5Q Arginine ornithine antiporter EN18_03555 ENOG4105CXN decarboxylase EN18_03560 ENOG4107RGH Aldehyde dehydrogenase EN18_03565 ENOG4105EW9 transcriptional regulator AsnC family EN18_03570 ENOG4105C8Q Methyl-accepting chemotaxis EN18_03580 ENOG4105CK7 Sodium proline symporter EN18_03590 ENOG4105C26 Dehydrogenase EN18_03605 ENOG4105E6M Sulphatase-modifying factor protein EN18_03615 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) EN18_03620 ENOG4107QZV Type I secretion membrane fusion protein EN18_03635 ENOG4108JJA ABC, transporter EN18_03645 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EN18_03655 ENOG4105C8Q Methyl-accepting chemotaxis EN18_03660 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) EN18_03665 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) EN18_03670 ENOG4105BZU Histidine kinase EN18_03675 ENOG4105C8Q Methyl-accepting chemotaxis EN18_03680 ENOG4108V3W Chemotaxis protein, CheW EN18_03685 ENOG4108V3W Chemotaxis protein, CheW EN18_03690 ENOG4105CBS Chea signal transduction histidine kinase EN18_03695 ENOG4105CBS Chea signal transduction histidine kinase EN18_03700 ENOG4108VYJ response regulator receiver protein EN18_03720 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EN18_03725 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EN18_03730 ENOG4108JQ6 ABC transporter EN18_03735 ENOG4105DIJ Phosphoethanolamine transferase EN18_03740 ENOG4105DHQ Histidine kinase EN18_03745 ENOG4105XJC Two component transcriptional regulator (Winged helix family EN18_03775 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) EN18_03780 ENOG4107RUE extracellular solute-binding protein family 1 EN18_03785 ENOG4106RMF ParB family EN18_03815 ENOG4105CDY transcriptional regulatory protein EN18_03820 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EN18_03825 ENOG4105C8Q Methyl-accepting chemotaxis EN18_03830 ENOG4108YYI Protein of unknown function (DUF2810) EN18_03835 ENOG41061ZR Transcriptional regulator EN18_03840 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) EN18_03845 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) EN18_03850 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) EN18_03855 ENOG4108WC9 type VI secretion system effector, hcp1 family EN18_03860 ENOG4105CS6 Rhs element vgr protein EN18_03885 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EN18_03895 ENOG4105C8P )-transporter EN18_03900 ENOG4108Q67 UPF0319 protein EN18_03925 ENOG4105C8Q Methyl-accepting chemotaxis EN18_03945 ENOG4105EYK Phosphatidylglycerophosphatase B EN18_03950 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) EN18_03975 ENOG4105D6U Sodium Glutamate Symporter EN18_03980 ENOG4105YE1 PilZ domain EN18_03995 ENOG4105EFX secretion protein, HlyD family EN18_04000 ENOG4105KK7 inner membrane protein YiaW EN18_04005 ENOG4106TD9 Diguanylate cyclase EN18_04020 ENOG4105D3A purine nucleoside phosphorylase DeoD-type EN18_04025 ENOG4107SEY Conserved Protein EN18_04035 ENOG4105CVP deoxyribo-dipyrimidine photolyase EN18_04040 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein EN18_04050 ENOG4105C1J atp-dependent rna helicase EN18_04055 ENOG4105CUG Oligopeptidase b EN18_04085 ENOG4105CVA phosphate EN18_04090 ENOG4105C8U phosphate abc transporter EN18_04095 ENOG4105E2Z phosphate ABC transporter (Permease EN18_04100 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EN18_04105 ENOG4105BZU Histidine kinase EN18_04115 ENOG4105DWD nucleoside recognition domain protein EN18_04120 ENOG4105CHH sulfate transporter EN18_04130 ENOG4105DR5 peptidase EN18_04135 ENOG4105BZU Histidine kinase EN18_04140 ENOG4105EQ2 LysR family Transcriptional regulator EN18_04145 ENOG4105E5M Multidrug resistance protein D EN18_04150 ENOG4108Z4X TRANSCRIPTIONal EN18_04170 ENOG4105CK2 sodium dicarboxylate symporter EN18_04215 ENOG4107RH7 Nicotinate phosphoribosyltransferase EN18_04220 ENOG4105D9R oxidoreductase EN18_04230 ENOG4105BZU Histidine kinase EN18_04235 ENOG4107VXZ Hydrolase EN18_04245 ENOG4105D3G Pseudouridine synthase EN18_04305 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EN18_04310 ENOG4108JUB Transcriptional regulator EN18_04335 ENOG4105CS6 Rhs element vgr protein EN18_04350 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) EN18_04355 ENOG4105C2J ABC transporter EN18_04360 ENOG4105CNN ABC, transporter EN18_04365 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator EN18_04370 ENOG4108RVA ribokinase EN18_04375 ENOG4105ETE Transcriptional regulator (LacI family EN18_04380 ENOG4106Z1T Nicotinamide Mononucleotide Transporter EN18_04385 ENOG4106Z1T Nicotinamide Mononucleotide Transporter EN18_04390 ENOG4108I5U Uridine phosphorylase EN18_04400 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase EN18_04405 ENOG4105CXY transporter EN18_04420 ENOG4105CQZ Histidine kinase EN18_04425 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EN18_04445 ENOG4105D5U fad dependent oxidoreductase EN18_04455 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EN18_04465 ENOG4105KJM monovalent cation h antiporter subunit g EN18_04470 ENOG41080TA Multiple resistance and ph regulation protein f EN18_04475 ENOG4105SC1 monovalent cation H antiporter subunit E EN18_04480 ENOG4108JPZ Monovalent cation H antiporter subunit D EN18_04485 ENOG4105MKQ Monovalent cation H antiporter subunit C EN18_04490 ENOG4105D65 subunit l EN18_04500 ENOG4105Q9Y Universal stress protein EN18_04505 ENOG4105CIC tryptophan-specific transport protein EN18_04510 ENOG4105C0F tryptophanase EC 4.1.99.1 EN18_04515 ENOG4105VRT cytoplasmic protein EN18_04530 ENOG4105BZU Histidine kinase EN18_04535 ENOG4105VEQ Cold shock protein EN18_04570 ENOG4105C7R Atpase associated with various cellular activities aaa_3 EN18_04575 ENOG41069D7 Methyl-accepting chemotaxis EN18_04590 ENOG4105D9N nucleoside EN18_04595 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) EN18_04605 ENOG4108JUA Transcriptional regulator EN18_04610 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) EN18_04615 ENOG4105VEQ Cold shock protein EN18_04635 ENOG4108UNF response regulator EN18_04645 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) EN18_04650 ENOG4105C5I Dehydrogenase EN18_04670 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EN18_04695 ENOG4108RS6 transposase EN18_04700 ENOG4105C1J atp-dependent rna helicase EN18_04705 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter EN18_04710 ENOG4107RA1 nh(3)-dependent nad( ) synthetase EN18_04715 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) EN18_04720 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase EN18_04725 ENOG4105BZU Histidine kinase EN18_04735 ENOG4107S6Z Na H antiporter EN18_04740 ENOG4105E5M Multidrug resistance protein D EN18_04750 ENOG4105BZU Histidine kinase EN18_04755 ENOG4105KUU lipolytic protein G-D-S-L family EN18_04760 ENOG4106M3D hemolysin EN18_04765 ENOG4108N3W hemolysin secretion protein EN18_04770 ENOG4107IFA Lipase (EC 3.1.1.3) EN18_04780 ENOG4107G87 m6 family metalloprotease domain protein EN18_04800 ENOG4105DHS permease protein EN18_04805 ENOG4105CM4 permease protein EN18_04810 ENOG4108IPW abc transporter atp-binding protein EN18_04830 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) EN18_04850 ENOG4105ETX regulatoR EN18_04865 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase EN18_04875 ENOG410667J hydrolase EN18_04905 ENOG4105DS1 cytochrome b561 EN18_04925 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EN18_05075 ENOG4105D07 Signal peptide peptidase, SppA EN18_05125 ENOG4105K70 DNA-binding protein EN18_05270 ENOG4108R0M Aminoglycoside EN18_05285 ENOG4107QJE Chromosome Partitioning Protein EN18_05370 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) EN18_05490 ENOG4105T95 Thiol disulfide interChange protein EN18_05550 ENOG4105GMT ATPase associated with various cellular activities aaa_5 EN18_05560 ENOG4108UUM single-stranded DNA-binding protein EN18_05605 ENOG4105XPH Ferredoxin EN18_05725 ENOG4105EQR Transposase IS116 IS110 IS902 EN18_05760 ENOG4105EKQ RNA-directed DNA polymerase EN18_05805 ENOG4105EQR Transposase IS116 IS110 IS902 EN18_05815 ENOG4105VUN Transcriptional regulator EN18_05870 ENOG4105EQR Transposase IS116 IS110 IS902 EN18_05925 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase EN18_05930 ENOG4105DJ0 Poly(A) Polymerase EN18_05935 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) EN18_05940 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters EN18_05945 ENOG4105PW4 Sugar fermentation stimulation protein homolog EN18_05955 ENOG4105CQ7 ATP-dependent helicase EN18_05960 ENOG4105BZ4 penicillin-binding protein EN18_05965 ENOG4105D78 K07001 NTE family protein EN18_05970 ENOG4107QIJ Aconitate hydratase 2 EN18_05975 ENOG4105XTV UPF0231 protein EN18_05980 ENOG4108YZA Nitrogen regulatory protein pii EN18_06000 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EN18_06010 ENOG4105E2V Glycosyltransferase 36 EN18_06015 ENOG4105E2D ec 3.2.1.52 EN18_06020 ENOG4105RD7 BadF BadG BcrA BcrD EN18_06030 ENOG4108JQ7 (ABC) transporter EN18_06035 ENOG4105C3U ABC transporter EN18_06040 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EN18_06050 ENOG4107QRA Extracellular solute-binding protein, family 5 EN18_06055 ENOG4105BZU Histidine kinase EN18_06060 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) EN18_06065 ENOG4105IPI Membrane EN18_06070 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase EN18_06080 ENOG4108YX9 iron--sulfur cluster insertion protein erpA EN18_06095 ENOG4105DR5 peptidase EN18_06100 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) EN18_06105 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase EN18_06110 ENOG4105FCK Membrane EN18_06115 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) EN18_06120 ENOG4105HBR Rna-binding protein EN18_06125 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) EN18_06130 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EN18_06135 ENOG4105EEI dihydropteroate synthase EN18_06140 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) EN18_06160 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) EN18_06165 ENOG4105CHV Transcription elongation factor NusA EN18_06170 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) EN18_06175 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) EN18_06180 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) EN18_06185 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) EN18_06190 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) EN18_06195 ENOG4105RT1 May be involved in cell division (By similarity) EN18_06210 ENOG4106RZ4 Peptidase U32 EN18_06215 ENOG4105CFP Peptidase U32 EN18_06220 ENOG4105BZU Histidine kinase EN18_06225 ENOG4105XPQ lipid carrier protein EN18_06230 ENOG4108YYD acetyltransferase EN18_06245 ENOG4105BZU Histidine kinase EN18_06280 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EN18_06330 ENOG4108R0M Aminoglycoside EN18_06380 ENOG4108R0M Aminoglycoside EN18_06485 ENOG4105T95 Thiol disulfide interChange protein EN18_06540 ENOG4105RWS endonuclease I EN18_06555 ENOG4108UUM single-stranded DNA-binding protein EN18_06575 ENOG4105GMT ATPase associated with various cellular activities aaa_5 EN18_06600 ENOG4108YGG dna repair protein EN18_06625 ENOG4108KB1 transcriptional regulator, arac family EN18_06710 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) EN18_06715 ENOG4105C1J atp-dependent rna helicase EN18_06720 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) EN18_06725 ENOG4105CWM branched-chain amino acid transport system II carrier protein EN18_06730 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) EN18_06735 ENOG4105CRK lysyL-tRNA synthetase EN18_06740 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EN18_06750 ENOG4105CPC Aldo Keto reductase EN18_06755 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) EN18_06765 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) EN18_06770 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase EN18_06775 ENOG4105HF0 Membrane EN18_06780 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) EN18_06785 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) EN18_06795 ENOG41063Z6 transcriptional regulator, lysR family EN18_06800 ENOG41080HT Transcriptional regulator, arsr family EN18_06805 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) EN18_06810 ENOG4105CJR Integral membrane protein (MviN EN18_06815 ENOG4105DTN riboflavin biosynthesis protein ribF EN18_06820 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) EN18_06825 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) EN18_06830 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase EN18_06835 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) EN18_06855 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate EN18_06860 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) EN18_06865 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) EN18_06870 ENOG4108NEV two component transcriptional regulator, LytTR family EN18_06875 ENOG4108HRK Histidine kinase EN18_06880 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) EN18_06895 ENOG4105C5H ABC transporter EN18_06900 ENOG4107SC1 transglycosylase EN18_06905 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) EN18_06910 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) EN18_06915 ENOG4108K0B C-di-gmp phosphodiesterase EN18_06920 ENOG4107XW0 Spermidine putrescine ABC transporter periplasmic spermidine putrescine-binding protein EN18_06930 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA EN18_06935 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane EN18_06940 ENOG4105C34 Pseudouridine synthase EN18_06945 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase EN18_06950 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EN18_06990 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding EN18_06995 ENOG4105CFP Peptidase U32 EN18_07000 ENOG4105DH7 May be involved in recombination (By similarity) EN18_07005 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EN18_07010 ENOG4105BZU Histidine kinase EN18_07020 ENOG4105C9X ppx gppa phosphatase EN18_07025 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) EN18_07030 ENOG4105C8U phosphate abc transporter EN18_07035 ENOG4105E2Z phosphate ABC transporter (Permease EN18_07040 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EN18_07050 ENOG4105CSR polyphosphate kinase 2 EN18_07055 ENOG4106N3A copper homeostasis protein cutc EN18_07060 ENOG4105D3R alkyl hydroperoxide reductase EN18_07065 ENOG4105C5Q Transcriptional regulator EN18_07070 ENOG4107QP3 malate synthase g EN18_07075 ENOG4108I9X Isocitrate lyase EN18_07080 ENOG4105W87 Cbs domain EN18_07085 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) EN18_07090 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) EN18_07095 ENOG4105VIE preprotein translocase, subunit YajC EN18_07100 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EN18_07105 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EN18_07110 ENOG4105ECY inositol monophosphatase EN18_07115 ENOG4105CVS RNA methyltransferase TrmH family, group 1 EN18_07120 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family EN18_07125 ENOG4105C3J Cysteine desulfurase EN18_07130 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins EN18_07135 ENOG4108Z4V iron-sulfur cluster assembly EN18_07140 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) EN18_07145 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB EN18_07150 ENOG4108ZIT Ferredoxin, 2FE-2S EN18_07155 ENOG4105WVQ Fe-S assembly protein IscX EN18_07160 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) EN18_07165 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) EN18_07170 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs EN18_07180 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) EN18_07185 ENOG4105CUT histidyl-tRNA synthetase EN18_07190 ENOG4105N21 Membrane EN18_07195 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) EN18_07200 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) EN18_07215 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EN18_07220 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EN18_07225 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EN18_07240 ENOG4106HK8 GPR1 FUN34 yaaH family protein EN18_07245 ENOG4105WQI isochorismatase EN18_07250 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase EN18_07255 ENOG4105E4F Isochorismate synthase EN18_07260 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase EN18_07270 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein EN18_07275 ENOG4105DQ5 transport system permease protein EN18_07280 ENOG4105TVJ transport system, permease EN18_07285 ENOG4105E0A ABC, transporter EN18_07295 ENOG41064T2 transcriptional regulator, lysR family EN18_07300 ENOG4105EUZ Beta-lactamase domain protein EN18_07305 ENOG4105BZG amino acid carrier protein EN18_07310 ENOG4105MWK D-amino acid dehydrogenase, small subunit EN18_07330 ENOG4106YYS transcriptional regulatory protein EN18_07335 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism EN18_07340 ENOG4105D9Q decarboxylase (Beta subunit) EN18_07345 ENOG4107QSA Oxaloacetate decarboxylase EN18_07360 ENOG4105DUA (citrate (pro-3S)-lyase ligase EN18_07365 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) EN18_07370 ENOG4105CI0 Citrate lyase EN18_07375 ENOG4105CHY citrate lyase, alpha EN18_07380 ENOG4105YGP holo-ACP synthase CitX EN18_07385 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase EN18_07400 ENOG4108Z4U Ferredoxin EN18_07405 ENOG4105DZ0 fad dependent oxidoreductase EN18_07465 ENOG4105C26 Dehydrogenase EN18_07485 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) EN18_07490 ENOG4107RK6 Methyl-accepting chemotaxis EN18_07505 ENOG4105XB6 Toxin coregulated pilin EN18_07520 ENOG4105GRU toxin co-regulated pilus biosynthesis outer membrane protein C EN18_07540 ENOG4107QHF type ii secretion system protein e EN18_07545 ENOG4108VEY type ii secretion system EN18_07560 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) EN18_07565 ENOG4105C8Q Methyl-accepting chemotaxis EN18_07585 ENOG4105DR5 peptidase EN18_07595 ENOG4105F88 accessory colonization factor AcfD EN18_07605 ENOG4105DFP Integrase EN18_07610 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) EN18_07615 ENOG4108Z1B Cyclase dehydrase EN18_07620 ENOG4105VDB UPF0125 protein EN18_07625 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) EN18_07630 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) EN18_07635 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) EN18_07640 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ EN18_07645 ENOG4105CFG Acts as a chaperone (By similarity) EN18_07650 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) EN18_07680 ENOG4105CFC Transporter EN18_07685 ENOG4108Z6B deaminase EN18_07695 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) EN18_07705 ENOG4107QIK phosphoribosylformylglycinamidine synthase EN18_07710 ENOG4108RS6 transposase EN18_07730 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) EN18_07735 ENOG4108R96 Methyltransferase, YaeB family EN18_07740 ENOG4105NRA 50s ribosomal protein l31 type b EN18_07750 ENOG4105CFC Transporter EN18_07755 ENOG4108UPT UPF0178 protein EN18_07765 ENOG4108428 Inherit from COG: -acetyltransferase EN18_07780 ENOG4105WP7 tRNA pseudouridine synthase C EN18_07785 ENOG4105DR9 pseudouridine synthase EN18_07790 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) EN18_07795 ENOG4105CTB Polyprenyl synthetase EN18_07805 ENOG4105E14 MotA TolQ exbB proton channel EN18_07815 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) EN18_07825 ENOG4105ETT transcriptional Regulator, LysR family EN18_07830 ENOG4105M08 Membrane EN18_07835 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease EN18_07840 ENOG4105EWT decarboxylase family EN18_07845 ENOG4105BZU Histidine kinase EN18_07855 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) EN18_07860 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) EN18_07865 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein EN18_07870 ENOG4105D01 (LipO)protein EN18_07875 ENOG4108UMI ABC transporter, permease EN18_07880 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EN18_07885 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase EN18_07890 ENOG4105D4X repressor EN18_07895 ENOG4105C5Y PTS System EN18_07900 ENOG4105CG3 alpha amylase, catalytic region EN18_07930 ENOG4105BZS acriflavin resistance protein EN18_07935 ENOG4107ZF2 Phosphatase EN18_07940 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase EN18_07950 ENOG4108UW5 maltose o-acetyltransferase EN18_07970 ENOG4105D7W serine acetyltransferase EN18_07980 ENOG4105Q84 sucrose synthase EN18_07990 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family EN18_08005 ENOG4108MA4 Peptidase M66 EN18_08020 ENOG4105D3Q Sugar transferase EN18_08030 ENOG4105DAY polysaccharide export protein EN18_08035 ENOG4105D75 Capsular exopolysaccharide family EN18_08055 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) EN18_08065 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) EN18_08070 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) EN18_08075 ENOG4108Z43 UPF0250 protein EN18_08080 ENOG4105DZ1 carboxypeptidase EN18_08085 ENOG4105K6T rare lipoprotein A EN18_08090 ENOG4105CNI cell division protein FtsW EN18_08095 ENOG4105CJN penicillin-binding protein EN18_08100 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) EN18_08105 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) EN18_08110 ENOG4105DJF DNA polymerase III, delta' subunit EN18_08115 ENOG4108U2H Rare lipoprotein B EN18_08120 ENOG4105C8T Leucyl-tRNA synthetase EN18_08125 ENOG4107PAI alpha helical protein EN18_08130 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) EN18_08135 ENOG4108JU5 Magnesium and cobalt efflux protein EN18_08140 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) EN18_08145 ENOG4105C9A Phoh family EN18_08150 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EN18_08155 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family EN18_08160 ENOG4105C5Y PTS System EN18_08170 ENOG4105KZ7 phosphocarrier protein hpr EN18_08175 ENOG4105C6T cysteine synthase EN18_08180 ENOG4105EXN Sulfate transport protein CysZ EN18_08185 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) EN18_08190 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) EN18_08195 ENOG41081QG Porin Gram-negative type EN18_08205 ENOG4108Z6Z Transcriptional regulator EN18_08210 ENOG4105G5H Membrane EN18_08215 ENOG4107QX8 SPFH domain, Band 7 family protein EN18_08220 ENOG4107QR8 Thioredoxin EN18_08230 ENOG4105E1F short-chain dehydrogenase reductase EN18_08235 ENOG4105ECP epimerase EN18_08240 ENOG4108RE9 Phosphodiesterase EN18_08255 ENOG4108TU9 TRANSCRIPTIONal EN18_08260 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) EN18_08265 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) EN18_08270 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) EN18_08275 ENOG4105DUX Transporter EN18_08280 ENOG4105MDZ Transcriptional activator rfaH EN18_08285 ENOG4105CAQ asparagine synthetase EN18_08290 ENOG4105CKD glutathione-regulated potassium-efflux system protein EN18_08295 ENOG4105E2R ROK family EN18_08300 ENOG4105CE4 GlcNAc 6-P deacetylase EN18_08305 ENOG4105CI1 PTS System EN18_08310 ENOG4105CX6 glutaminyL-tRNA synthetase EN18_08320 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) EN18_08325 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) EN18_08330 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase EN18_08335 ENOG4108S3P Sporulation domain protein EN18_08340 ENOG4105E96 Colicin v production protein EN18_08345 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase EN18_08350 ENOG4105D3Y Na H antiporter EN18_08355 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) EN18_08365 ENOG4105EIY sodium-type flagellar protein motY EN18_08370 ENOG4106WH9 Protein of unknown function (DUF2753) EN18_08375 ENOG4108UYE Lactoylglutathione lyase EN18_08380 ENOG4105CSM endonuclease III EN18_08385 ENOG4105DZB Electron transport complex EN18_08390 ENOG4108UQQ Electron transport complex EN18_08395 ENOG4105D6A Electron transport complex EN18_08405 ENOG4108R3D Electron transport complex EN18_08425 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) EN18_08435 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EN18_08445 ENOG4105CHW UPF0052 protein EN18_08450 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EN18_08455 ENOG4108RIR Molybdenum cofactor biosynthesis protein EN18_08460 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EN18_08465 ENOG4105M00 molybdopterin converting factor, subunit 1 EN18_08470 ENOG4108ZAF Molybdopterin EN18_08475 ENOG4105BZU Histidine kinase EN18_08490 ENOG4108I5U Uridine phosphorylase EN18_08500 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) EN18_08505 ENOG4105D1F ATP-binding protein EN18_08515 ENOG4105DBI uridine monophosphokinase EN18_08520 ENOG4108GAE asmA family EN18_08525 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase EN18_08535 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation EN18_08540 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation EN18_08565 ENOG4105CHU acetyl-coa acetyltransferase EN18_08570 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EN18_08575 ENOG41069NU Nitroreductase EN18_08580 ENOG4105EJC lysr family transcriptional regulator EN18_08585 ENOG4105I93 response regulator EN18_08595 ENOG4105WD1 Membrane EN18_08600 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) EN18_08605 ENOG4107QMP dna polymerase iii subunits gamma and tau EN18_08610 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) EN18_08615 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) EN18_08620 ENOG4105KRS Proteinase inhibitor EN18_08630 ENOG4105UBK short-chain dehydrogenase reductase EN18_08635 ENOG4105ERU peptidase EN18_08645 ENOG4108XM1 transcriptional regulator AsnC family EN18_08650 ENOG4105C29 acyl-CoA thioesterase EN18_08670 ENOG4105BZU Histidine kinase EN18_08675 ENOG41082YX Transcriptional regulator, arsr family EN18_08680 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EN18_08705 ENOG4108V1U phospholipid-binding protein EN18_08725 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EN18_08740 ENOG4107YTP response regulator receiver protein EN18_08750 ENOG4105BZU Histidine kinase EN18_08755 ENOG4105BZU Histidine kinase EN18_08760 ENOG4105BZU Histidine kinase EN18_08765 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EN18_08780 ENOG4107QSI ABC, transporter EN18_08785 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EN18_08790 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EN18_08795 ENOG4105C3U ABC transporter EN18_08800 ENOG4108JQ7 (ABC) transporter EN18_08805 ENOG4105CHF Glutathione S-transferase EN18_08810 ENOG4108DNC Involved in acetate metabolism (By similarity) EN18_08815 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) EN18_08820 ENOG4105PQ6 UPF0208 membrane protein EN18_08825 ENOG4105VYA Uncharacterized conserved protein (DUF2132) EN18_08835 ENOG4105C7J ABC transporter, permease EN18_08840 ENOG4108JJB ABC transporter EN18_08845 ENOG4105BZU Histidine kinase EN18_08850 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) EN18_08855 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving EN18_08865 ENOG4105D1H recombination factor protein RarA EN18_08870 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) EN18_08875 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EN18_08880 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) EN18_08885 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EN18_08890 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) EN18_08895 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) EN18_08905 ENOG4105D0M Protease HtpX homolog EN18_08915 ENOG4107FW0 short-chain dehydrogenase reductase EN18_08930 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase EN18_08940 ENOG4105RHG EN18_08950 ENOG4107QTF adenylosuccinate lyase EN18_08955 ENOG41075W9 High frequency lysogenization protein HflD homolog EN18_08960 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) EN18_08965 ENOG4107RE1 Inosine-guanosine kinase EN18_08975 ENOG4107S6Z Na H antiporter EN18_08980 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) EN18_08985 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) EN18_08990 ENOG4105CIH Imidazole acetol-phosphate transaminase EN18_08995 ENOG4105ECC imidazole-glycerol-phosphate dehydratase EN18_09000 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) EN18_09005 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase EN18_09010 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) EN18_09015 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase EN18_09020 ENOG4108R99 pseudouridine synthase EN18_09030 ENOG4105VEQ Cold shock protein EN18_09035 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) EN18_09040 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EN18_09050 ENOG41090BQ Glutaredoxin EN18_09055 ENOG4108EKI Dehydrogenase EN18_09060 ENOG4106KNT transcriptional regulator EN18_09065 ENOG4105DY8 decarboxylase EN18_09075 ENOG4105DWU Membrane EN18_09100 ENOG4105CUX Signal transduction histidine kinase EN18_09110 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) EN18_09125 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) EN18_09130 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) EN18_09135 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) EN18_09140 ENOG41081XQ Conserved Protein EN18_09145 ENOG4105C9M aspartyl-trna synthetase EN18_09150 ENOG4107104 thymidine kinase EN18_09155 ENOG4105CK2 sodium dicarboxylate symporter EN18_09160 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) EN18_09165 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) EN18_09170 ENOG4105DK0 Indole-3-glycerol phosphate synthase EN18_09175 ENOG4108I0Q anthranilate phosphoribosyltransferase EN18_09180 ENOG4105DDQ anthranilate synthase EN18_09185 ENOG4105CRQ synthase (Component I) EN18_09195 ENOG4105DB7 PHP domain protein EN18_09200 ENOG4107RTD sua5 ycio yrdc ywlc family protein EN18_09205 ENOG4105FE9 pseudouridine synthase EN18_09210 ENOG4108JJ8 (ABC) transporter EN18_09215 ENOG4108JJ9 ABC, transporter EN18_09220 ENOG4105C3M thioredoxin reductase EN18_09230 ENOG4105C9B Cysteine desulfurase EN18_09235 ENOG4105BZU Histidine kinase EN18_09240 ENOG4107GZ4 SanA protein EN18_09250 ENOG4107R1I NAD-dependent malic enzyme EN18_09260 ENOG4105C8V SAICAR synthetase EN18_09280 ENOG4108ZG0 Ompa motb domain protein EN18_09295 ENOG4105CQB FAD linked oxidase domain protein EN18_09305 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap EN18_09315 ENOG4105C84 Histidine ammonia-lyase EN18_09320 ENOG4105CGP Urocanate hydratase EN18_09325 ENOG41088SP formiminoglutamate hydrolase EN18_09330 ENOG4105CI2 imidazolone-5-propionate hydrolase EN18_09335 ENOG4105CZE histidine utilization repressor EN18_09350 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) EN18_09360 ENOG4105BZU Histidine kinase EN18_09365 ENOG4105CQ2 DNA polymerase EN18_09370 ENOG4105WH1 Two component transcriptional regulator luxr family EN18_09375 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) EN18_09405 ENOG4105BZU Histidine kinase EN18_09415 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) EN18_09420 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) EN18_09425 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) EN18_09440 ENOG4105FQ6 thiopurine methyltransferase EN18_09455 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) EN18_09460 ENOG41067MG lrgb family EN18_09470 ENOG4105CJB Exodeoxyribonuclease I EN18_09475 ENOG4108ETY sodium dicarboxylate symporter EN18_09480 ENOG4105E0X reductase EN18_09490 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) EN18_09495 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) EN18_09500 ENOG4108YZT Adenosylcobinamide kinase EN18_09515 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) EN18_09520 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) EN18_09535 ENOG4105C8Q Methyl-accepting chemotaxis EN18_09560 ENOG4107QK7 reductase EN18_09565 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EN18_09570 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EN18_09575 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) EN18_09580 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EN18_09585 ENOG4105C72 UPF0176 protein EN18_09595 ENOG4105S8Q sugar efflux transporter EN18_09605 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) EN18_09630 ENOG4105DIT ErfK YbiS YcfS YnhG family protein EN18_09635 ENOG4105EAQ (twin-arginine translocation) pathway signal EN18_09640 ENOG4105C5X domain protein EN18_09655 ENOG4105CH5 extracellular solute-binding protein, family 7 EN18_09665 ENOG4105CG6 trap dicarboxylate transporter dctm subunit EN18_09680 ENOG41067TZ transcriptional regulator, MarR family EN18_09685 ENOG4105C94 Transporter EN18_09695 ENOG4105VZJ PTS System EN18_09705 ENOG4105VCP PTS System EN18_09710 ENOG4105F8D glycoside hydrolase family 4 EN18_09715 ENOG410901P UPF0249 protein EN18_09720 ENOG41060NJ transcriptional regulator EN18_09725 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) EN18_09730 ENOG4105DJ9 glucan biosynthesis protein EN18_09735 ENOG4105C8Q Methyl-accepting chemotaxis EN18_09750 ENOG4105CGF Aromatic amino acid aminotransferase EN18_09760 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase EN18_09770 ENOG4105C5S asparaginyl-tRNA synthetase EN18_09775 ENOG4108NVR Methyl-accepting chemotaxis EN18_09780 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase EN18_09785 ENOG4105EJQ L-serine dehydratase EN18_09790 ENOG4105C44 Serine transporter EN18_09795 ENOG4105P8F nudix hydrolase EN18_09800 ENOG4105CRQ synthase (Component I) EN18_09815 ENOG4105CM6 amino acid regulated cytosolic protein EN18_09825 ENOG4108JU8 Transcriptional regulator EN18_09830 ENOG4105D9U N-acetyltransferase EN18_09845 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EN18_09850 ENOG4108NVR Methyl-accepting chemotaxis EN18_09855 ENOG4105C8P )-transporter EN18_09860 ENOG4105BZU Histidine kinase EN18_09865 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EN18_09870 ENOG4108MJ5 VirK protein EN18_09875 ENOG4105RW8 MltA-interacting MipA family protein EN18_09880 ENOG4105EB3 Histidine kinase EN18_09885 ENOG4107EXC regulatoR EN18_09910 ENOG4105C2J ABC transporter EN18_09915 ENOG4107SDZ Galactoside transport system permease protein mglC EN18_09945 ENOG41073TP transcriptional regulator EN18_09950 ENOG4105CR4 methylisocitrate lyase EN18_09955 ENOG4105BZN citrate synthase EN18_09960 ENOG4108I0Z Aconitate hydratase EN18_09965 ENOG4105C7F AcnD-accessory protein PrpF EN18_09970 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EN18_09985 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) EN18_09995 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase EN18_10000 ENOG4105F1J Homogentisate 1,2-dioxygenase EN18_10010 ENOG4108RXX maleylacetoacetate isomerase EN18_10015 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase EN18_10020 ENOG4105BZU Histidine kinase EN18_10030 ENOG4106TD9 Diguanylate cyclase EN18_10035 ENOG4105DR4 Methyltransferase EN18_10040 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 EN18_10045 ENOG4108Z0T Part of a sulfur-relay system (By similarity) EN18_10050 ENOG4108MN8 Membrane EN18_10055 ENOG4105CDA abc transporter atp-binding protein EN18_10060 ENOG4105DRP amino acid AbC transporter EN18_10065 ENOG4105EZ7 amino acid ABC transporter EN18_10070 ENOG4107QXX ABC transporter EN18_10080 ENOG410667J hydrolase EN18_10085 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) EN18_10090 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) EN18_10110 ENOG4105BZU Histidine kinase EN18_10120 ENOG4105BZU Histidine kinase EN18_10125 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB EN18_10130 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB EN18_10140 ENOG4105BZU Histidine kinase EN18_10160 ENOG4105CQ7 ATP-dependent helicase EN18_10170 ENOG4105R8A Heat shock protein EN18_10175 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) EN18_10180 ENOG4105EJC lysr family transcriptional regulator EN18_10185 ENOG4105C0R drug resistance transporter emrb qaca subfamily EN18_10190 ENOG4105CVP deoxyribo-dipyrimidine photolyase EN18_10195 ENOG4105KPY Small multidrug resistance protein EN18_10200 ENOG4108NVR Methyl-accepting chemotaxis EN18_10205 ENOG4108VYJ response regulator receiver protein EN18_10215 ENOG4105CBS Chea signal transduction histidine kinase EN18_10220 ENOG4105CBS Chea signal transduction histidine kinase EN18_10225 ENOG4105BZU Histidine kinase EN18_10235 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) EN18_10240 ENOG4108V3W Chemotaxis protein, CheW EN18_10245 ENOG4105C8Q Methyl-accepting chemotaxis EN18_10250 ENOG4108N3W hemolysin secretion protein EN18_10255 ENOG4107SDU Methyl-accepting chemotaxis EN18_10260 ENOG4105C1J atp-dependent rna helicase EN18_10270 ENOG4105ENJ RND efflux system, outer membrane lipoprotein EN18_10275 ENOG4105CW7 secretion protein, HlyD family EN18_10280 ENOG4105C0R drug resistance transporter emrb qaca subfamily EN18_10285 ENOG4105C8Q Methyl-accepting chemotaxis EN18_10290 ENOG4105CTD carboxy-peptidase EN18_10295 ENOG4108WC9 type VI secretion system effector, hcp1 family EN18_10300 ENOG4105CS6 Rhs element vgr protein EN18_10325 ENOG410829K Lysine exporter protein (Lyse ygga) EN18_10330 ENOG4105BZG amino acid carrier protein EN18_10345 ENOG4107RUE extracellular solute-binding protein family 1 EN18_10350 ENOG4107RUE extracellular solute-binding protein family 1 EN18_10355 ENOG4105D38 putrescine abc transporter EN18_10360 ENOG4105F38 ABC transporter, permease EN18_10365 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EN18_10385 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) EN18_10390 ENOG4105Q9Y Universal stress protein EN18_10395 ENOG4105DS0 Transcriptional regulator, Crp Fnr family EN18_10410 ENOG4105C59 p-type ATPase EN18_10420 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) EN18_10435 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i EN18_10450 ENOG4105BZU Histidine kinase EN18_10475 ENOG4108RC6 RTX toxin EN18_10480 ENOG4105EUK rtx toxin RtxA EN18_10490 ENOG4107927 Cholera enterotoxin, A subunit EN18_10495 ENOG4105MQ5 zona occludens toxin EN18_10530 ENOG4105TIV Cryptic phage CTXphi transcriptional repressor RstR EN18_10550 ENOG4105TIV Cryptic phage CTXphi transcriptional repressor RstR EN18_10615 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) EN18_10620 ENOG4105DAN ATP-dependent protease EN18_10625 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) EN18_10635 ENOG4105C5H ABC transporter EN18_10645 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) EN18_10650 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) EN18_10655 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) EN18_10660 ENOG4105C7I Dehydrogenase EN18_10670 ENOG4105CD8 aminopeptidase N EN18_10680 ENOG4105CN1 protease EN18_10685 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) EN18_10690 ENOG4108ZGC gaf domain protein EN18_10695 ENOG4105BZ1 (ABC) transporter EN18_10700 ENOG4105H2K paraquat-inducible protein a EN18_10705 ENOG4105DY2 Paraquat-inducible protein b EN18_10710 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B EN18_10715 ENOG4105QNR S1 RNA binding domain protein EN18_10730 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) EN18_10740 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) EN18_10755 ENOG4105QAX Iron-sulfur EN18_10760 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) EN18_10770 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) EN18_10790 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) EN18_10795 ENOG4105C5H ABC transporter EN18_10800 ENOG4105BZU Histidine kinase EN18_10805 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EN18_10815 ENOG4107A5B Binding-protein-dependent transport systems, inner membrane component EN18_10820 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EN18_10825 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) EN18_10830 ENOG4105CVM Molybdenum cofactor synthesis domain protein EN18_10855 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) EN18_10860 ENOG4106IUH DTW domain containing protein EN18_10870 ENOG4105C8Q Methyl-accepting chemotaxis EN18_10875 ENOG4107TT5 NLP P60 protein EN18_10885 ENOG4105FGM Fructosamine kinase EN18_10895 ENOG4107QI1 Mate efflux family protein EN18_10915 ENOG41067XB TonB family EN18_10920 ENOG4109015 Biopolymer transport protein exbD tolR EN18_10950 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component EN18_10955 ENOG4108IJ9 (ABC) transporter EN18_10960 ENOG4105E98 transcriptional regulator DeoR family EN18_10965 ENOG4107VXM glycerophosphoryl diester phosphodiesterase EN18_10970 ENOG4105XEP YhcH YjgK YiaL family protein EN18_10975 ENOG4105M4H endoribonuclease L-psp EN18_10980 ENOG4105DDV Transcriptional regulator (LacI family EN18_10985 ENOG4105CS2 ec 3.2.1.21 EN18_10990 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) EN18_11005 ENOG4107QZV Type I secretion membrane fusion protein EN18_11015 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EN18_11020 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EN18_11025 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EN18_11030 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EN18_11035 ENOG4105C4M (Ubiquinol oxidase) subunit I EN18_11045 ENOG4105C9Q fumarate hydratase class II EN18_11075 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) EN18_11080 ENOG4105DUM transcriptional regulator, lysR family EN18_11085 ENOG4108TWJ NADH dehydrogenase subunit 5 EN18_11095 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EN18_11105 ENOG4105CH6 catalase EN18_11125 ENOG4105C7K acetolactate synthase EN18_11135 ENOG4105BZU Histidine kinase EN18_11140 ENOG4106TD9 Diguanylate cyclase EN18_11145 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) EN18_11150 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) EN18_11155 ENOG4105F0Z galactose-1-phosphate uridylyltransferase EN18_11185 ENOG4105BZU Histidine kinase EN18_11200 ENOG4107R88 Chemotaxis protein (CheV) EN18_11210 ENOG4106YYS transcriptional regulatory protein EN18_11215 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism EN18_11230 ENOG4107V40 secretion protein, HlyD family EN18_11250 ENOG4105CVG Homoserine O-transsuccinylase EN18_11255 ENOG41090FY type IV pilus biogenesis stability protein PilW EN18_11265 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) EN18_11270 ENOG4108VKG metal-dependent hydrolase EN18_11280 ENOG4105F04 LysR family Transcriptional regulator EN18_11300 ENOG4105DFG type I secretion outer membrane protein EN18_11305 ENOG4105CDV Ompa motb domain protein EN18_11310 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) EN18_11315 ENOG4105E3Q saccharopine dehydrogenase EN18_11325 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) EN18_11340 ENOG4108I0Y (ABC) transporter EN18_11345 ENOG4105UQX Mate efflux family protein EN18_11350 ENOG4105CGD Nad-dependent epimerase dehydratase EN18_11360 ENOG4105C2C drug resistance transporter, Bcr CflA EN18_11365 ENOG4105I08 Pseudouridine synthase EN18_11370 ENOG4105CFI type iii restriction protein res subunit EN18_11390 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) EN18_11410 ENOG4108N3W hemolysin secretion protein EN18_11440 ENOG4105KXC Collagenase EN18_11450 ENOG4105BZU Histidine kinase EN18_11455 ENOG4105BZU Histidine kinase EN18_11460 ENOG4105CJW magnesium transporter EN18_11475 ENOG4105C44 Serine transporter EN18_11485 ENOG4105CJ1 ABC, transporter EN18_11490 ENOG4107QWP ABC-2 type transporter EN18_11500 ENOG4105XZD Fe-S protein EN18_11510 ENOG4105VNH ABC transporter solute-binding protein EN18_11515 ENOG4105CXZ ABC transporter, permease EN18_11520 ENOG4108VGW abc transporter atp-binding protein EN18_11525 ENOG4108T9J Cdp-alcohol phosphatidyltransferase EN18_11530 ENOG4108W1A pseudouridine synthase EN18_11535 ENOG4105C8J )-transporter EN18_11540 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) EN18_11545 ENOG4105C28 cystathionine EN18_11550 ENOG4108R3E Dna-3-methyladenine glycosylase i EN18_11565 ENOG4105C1P efflux transporter, rnd family, mfp subunit EN18_11580 ENOG41087YS Phage shock protein A EN18_11585 ENOG4105E51 psp operon transcriptional activator EN18_11590 ENOG4108J59 Extracellular solute-binding protein, family 5 EN18_11595 ENOG4108I5W peptide transport system, permease protein EN18_11600 ENOG4108EU3 peptide transport system, permease EN18_11605 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein EN18_11610 ENOG4108JQ2 peptide transport system atp-binding protein EN18_11625 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase EN18_11645 ENOG4107QY8 reductase EN18_11665 ENOG4105TMB Formate nitrite transporter EN18_11675 ENOG4108535 NAD dependent epimerase/dehydratase family EN18_11680 ENOG4105GFG DUF218 domain EN18_11690 ENOG4107835 probably involved in intracellular septation (By similarity) EN18_11695 ENOG4105NAU thioesterase Superfamily protein EN18_11700 ENOG4105K9H YciI-like protein EN18_11710 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) EN18_11735 ENOG4105BZU Histidine kinase EN18_11740 ENOG4105CCT upf0313 protein EN18_11750 ENOG4105EW9 transcriptional regulator AsnC family EN18_11755 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) EN18_11760 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) EN18_11765 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) EN18_11770 ENOG4106371 Methyltransferase EN18_11775 ENOG4107S90 membrAne EN18_11780 ENOG4106WF9 DNA-binding transcriptional regulator TorR EN18_11785 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) EN18_11790 ENOG4105ETE Transcriptional regulator (LacI family EN18_11795 ENOG4105HP8 regulator of competence-specific genes EN18_11815 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) EN18_11820 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) EN18_11825 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) EN18_11830 ENOG4105RKX Protein of unknown function (DUF2498) EN18_11835 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase EN18_11845 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) EN18_11850 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate EN18_11855 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) EN18_11865 ENOG4107QPN acyl-Coa dehydrogenase EN18_11870 ENOG41067SE Tetr family transcriptional regulator EN18_11880 ENOG4105MTM Protein of unknown function (DUF1496) EN18_11885 ENOG4105C26 Dehydrogenase EN18_11890 ENOG4108R86 Transcriptional regulator EN18_11915 ENOG4105F1S paraquat-inducible protein a EN18_11920 ENOG4105DY2 Paraquat-inducible protein b EN18_11945 ENOG4105DFP Integrase EN18_11955 ENOG4105C0D helicase EN18_11975 ENOG4105DZR Type I site-specific deoxyribonuclease EN18_11995 ENOG4105CVR type I restriction-modification system EN18_12015 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) EN18_12020 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) EN18_12025 ENOG4105QEK Transcriptional regulator EN18_12035 ENOG4105CG6 trap dicarboxylate transporter dctm subunit EN18_12040 ENOG41069H7 transport system small permease component EN18_12045 ENOG4108ERU trap dicarboxylate transporter subunit DctP EN18_12050 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) EN18_12055 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) EN18_12060 ENOG4105CE4 GlcNAc 6-P deacetylase EN18_12065 ENOG4108478 ec 3.2.1.18 EN18_12075 ENOG4108YGG dna repair protein EN18_12095 ENOG4108NYK Tape measure protein EN18_12215 ENOG4105CVP deoxyribo-dipyrimidine photolyase EN18_12225 ENOG4105VYA Uncharacterized conserved protein (DUF2132) EN18_12230 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family EN18_12235 ENOG4105C26 Dehydrogenase EN18_12245 ENOG4105DM4 PTS System EN18_12250 ENOG4105DM4 PTS System EN18_12255 ENOG4108YRF PTS System EN18_12265 ENOG4106R3P AraC family transcriptional regulator EN18_12270 ENOG4105DM4 PTS System EN18_12275 ENOG4105EIP mannose-6-phosphate isomerase EN18_12280 ENOG4108RNS Exports L-alanine (By similarity) EN18_12285 ENOG4105BZU Histidine kinase EN18_12295 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) EN18_12305 ENOG4105KCK Peptidoglycan-associated lipoprotein EN18_12310 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) EN18_12320 ENOG4105M8F Biopolymer transport protein exbD tolR EN18_12325 ENOG4105E02 MotA TolQ exbB proton channel EN18_12330 ENOG4107YD3 Thioesterase EN18_12335 ENOG4105KJB cyd operon protein YbgE EN18_12345 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EN18_12350 ENOG4105C4M (Ubiquinol oxidase) subunit I EN18_12355 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) EN18_12360 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) EN18_12365 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) EN18_12370 ENOG4105C8N cysteinyl-tRNA synthetase EN18_12375 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) EN18_12380 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) EN18_12385 ENOG4105D58 Diguanylate phosphodiesterase EN18_12400 ENOG4105ZU8 porin-like protein H EN18_12405 ENOG4105DVT helicase EN18_12410 ENOG4105EJ9 Membrane EN18_12415 ENOG4108URS primosomal replication protein n'' EN18_12420 ENOG4106428 Protein of unknown function (DUF2496) EN18_12425 ENOG4105C8Q Methyl-accepting chemotaxis EN18_12430 ENOG4105CGK Exodeoxyribonuclease III EN18_12435 ENOG4106YG3 ABC transporter EN18_12440 ENOG4105DSP amino acid AbC transporter EN18_12445 ENOG4105E89 ABC transporter EN18_12450 ENOG4108JEH abc transporter atp-binding protein EN18_12460 ENOG4105C6N Formate acetyltransferase EN18_12470 ENOG4108N3W hemolysin secretion protein EN18_12475 ENOG4105F1A Pyruvate formate-lyase EN18_12485 ENOG4105XWI UPF0304 protein EN18_12490 ENOG4105CYN Serine protein kinase EN18_12495 ENOG4106AKX UPF0229 protein EN18_12500 ENOG4105ED1 spovr family EN18_12505 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) EN18_12515 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) EN18_12520 ENOG4105BZ1 (ABC) transporter EN18_12525 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 EN18_12535 ENOG4105D60 lipoprotein releasing system transmembrane protein EN18_12540 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EN18_12545 ENOG4105D60 lipoprotein releasing system transmembrane protein EN18_12555 ENOG4108JA2 transcriptioN-repair coupling factor EN18_12565 ENOG4106M3D hemolysin EN18_12575 ENOG4105CEP NADH dehydrogenase EN18_12605 ENOG4105K59 histidine triad (HIT) protein EN18_12610 ENOG4108NVR Methyl-accepting chemotaxis EN18_12620 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) EN18_12625 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) EN18_12630 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) EN18_12635 ENOG4105CNU cell division protein FtsK EN18_12640 ENOG4105EW9 transcriptional regulator AsnC family EN18_12645 ENOG4105DCF alanine dehydrogenase EN18_12655 ENOG4107R11 Transcriptional regulator EN18_12670 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase EN18_12675 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) EN18_12680 ENOG4105CFV Tetratricopeptide repeat protein EN18_12685 ENOG4105Q4A inner membrane protein yciS EN18_12690 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) EN18_12695 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) EN18_12700 ENOG4105CAT Cytidine monophosphate kinase EN18_12705 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein EN18_12710 ENOG4105EIN peptidylprolyl cis-trans isomerase EN18_12715 ENOG4105K70 DNA-binding protein EN18_12720 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) EN18_12725 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) EN18_12730 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EN18_12735 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation EN18_12750 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EN18_12755 ENOG4105CG6 trap dicarboxylate transporter dctm subunit EN18_12760 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ EN18_12765 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit EN18_12770 ENOG4105CNG UPF0061 protein EN18_12785 ENOG4105BZU Histidine kinase EN18_12795 ENOG4108HPI phosphatidate Cytidylyltransferase EN18_12830 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) EN18_12850 ENOG4105JQN Transcriptional regulator EN18_12860 ENOG4107QY8 reductase EN18_12865 ENOG4105CUW cytochrome C-TYPE protein EN18_12870 ENOG410662T chitinase EN18_12875 ENOG4105D9N nucleoside EN18_12885 ENOG4105JQN Transcriptional regulator EN18_12890 ENOG4105CVE Lytic murein transglycosylase EN18_12895 ENOG4105VNG YcgL domain-containing protein EN18_12900 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) EN18_12905 ENOG4107QMS site-determining protein EN18_12910 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) EN18_12935 ENOG4107S74 Lysophospholipid transporter LplT EN18_12945 ENOG4108N3W hemolysin secretion protein EN18_12950 ENOG4108JCI Transcriptional regulator EN18_12955 ENOG4105DKK Benzoate EN18_12960 ENOG4105CEY Amp-dependent synthetase and ligase EN18_12965 ENOG4105DNI Converts SHCHC to OSB (By similarity) EN18_12970 ENOG4108IPT Naphthoate synthase EN18_12975 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) EN18_12980 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) EN18_12985 ENOG4105E4F Isochorismate synthase EN18_12990 ENOG4105CHM Aminotransferase EN18_12995 ENOG4105DK2 UPF0207 protein EN18_13000 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein EN18_13020 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) EN18_13025 ENOG4105CEY Amp-dependent synthetase and ligase EN18_13030 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) EN18_13045 ENOG41072GX Peptidase M22 Glycoprotease EN18_13050 ENOG4105DVT helicase EN18_13060 ENOG4105CIY formyltetrahydrofolate deformylase EN18_13065 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EN18_13070 ENOG4105D07 Signal peptide peptidase, SppA EN18_13075 ENOG4105HDK L-asparaginase EN18_13080 ENOG4105VUT cytoplasmic protein EN18_13090 ENOG4105E0X reductase EN18_13095 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EN18_13100 ENOG4105DSB aldose 1-epimerase EN18_13110 ENOG4105DHI Methyltransferase EN18_13125 ENOG4107R88 Chemotaxis protein (CheV) EN18_13130 ENOG4105DAG ROK family EN18_13135 ENOG4105CA9 Pyruvate kinase EN18_13140 ENOG4108NRW Phospholipase, patatin family EN18_13155 ENOG4105C8J )-transporter EN18_13165 ENOG4105CI1 PTS System EN18_13170 ENOG4105F8V Hydrolase, tatD family EN18_13175 ENOG4107QRG dna polymerase iii EN18_13180 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) EN18_13185 ENOG4105HHA aminodeoxychorismate lyase EN18_13190 ENOG4105YAZ 4-amino-4-deoxychorismate lyase EN18_13195 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EN18_13200 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EN18_13205 ENOG4105CHR reductase EN18_13210 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase EN18_13215 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) EN18_13220 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) EN18_13225 ENOG4105VGS 50s ribosomal protein l32 EN18_13230 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein EN18_13235 ENOG4108UHJ MAF-like protein EN18_13240 ENOG4105EI2 Pseudouridine synthase EN18_13250 ENOG4105C03 ribonuclease EN18_13255 ENOG4105CHH sulfate transporter EN18_13265 ENOG4108EKI Dehydrogenase EN18_13270 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein EN18_13275 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) EN18_13280 ENOG4105DFD Na H antiporter EN18_13290 ENOG4106V8H Nucleoid-associated protein EN18_13300 ENOG4105E68 Sulfatase EN18_13315 ENOG4105DGU Histone deacetylase EN18_13320 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) EN18_13325 ENOG4105M2J Glutaredoxin EN18_13330 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EN18_13345 ENOG410903C (LipO)protein EN18_13355 ENOG4105KWW Biogenesis protein EN18_13360 ENOG4107QX9 Thiol disulfide interChange protein EN18_13365 ENOG4105DA4 cytochrome c-type biogenesis protein EN18_13370 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) EN18_13375 ENOG41067VX Heme exporter protein EN18_13380 ENOG41060IM Heme exporter protein EN18_13385 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) EN18_13390 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) EN18_13400 ENOG4108V3W Chemotaxis protein, CheW EN18_13410 ENOG4107QJE Chromosome Partitioning Protein EN18_13415 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) EN18_13420 ENOG4105CBS Chea signal transduction histidine kinase EN18_13425 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) EN18_13430 ENOG4108VYJ response regulator receiver protein EN18_13435 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EN18_13440 ENOG4107R21 site-determining protein EN18_13445 ENOG4105FZW flagellar biosynthesis regulator FlhF EN18_13450 ENOG4105D7B Flagellar biosynthesis protein flha EN18_13455 ENOG4108BY2 phosphohistidine phosphatase EN18_13460 ENOG4108JQM Insulinase (Peptidase family M16) EN18_13470 ENOG4105C75 arginyL-tRNA synthetase EN18_13490 ENOG4105XFK Ferrous iron transport protein A EN18_13495 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) EN18_13500 ENOG4105NXV High-affinity zinc uptake system protein EN18_13505 ENOG4105FDK ABC transporter EN18_13510 ENOG4105FAV ABC, transporter EN18_13515 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha EN18_13520 ENOG4105CMV Succinyl-CoA synthetase subunit beta EN18_13525 ENOG4105C7S Dehydrogenase EN18_13530 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 EN18_13535 ENOG4105E33 succinate dehydrogenase EN18_13540 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) EN18_13545 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein EN18_13550 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit EN18_13555 ENOG4105BZN citrate synthase EN18_13560 ENOG4107QNR UPF0135 protein EN18_13570 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 EN18_13575 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) EN18_13580 ENOG4105EV9 Alpha Beta Hydrolase EN18_13590 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) EN18_13595 ENOG41067MG lrgb family EN18_13600 ENOG4105VAW lrga family EN18_13605 ENOG4105CMU LysR family (Transcriptional regulator EN18_13615 ENOG41090R7 Ferric uptake EN18_13620 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) EN18_13625 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) EN18_13630 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EN18_13635 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) EN18_13640 ENOG4105Q8W reductase EN18_13645 ENOG4105MH2 YfcL protein EN18_13650 ENOG4108BPE -transporting atpase EN18_13655 ENOG4105EN6 Membrane EN18_13660 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase EN18_13665 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) EN18_13675 ENOG4105D00 flagellar biosynthetic protein flhB EN18_13680 ENOG4105D19 Role in flagellar biosynthesis (By similarity) EN18_13685 ENOG4105VS8 Flagellar biosynthetic protein fliq EN18_13690 ENOG4105CN7 Flagellar biosynthetic protein FliP EN18_13695 ENOG4105VTB flagellar biosynthesis protein fliO EN18_13700 ENOG4105DD5 Flagellar motor switch protein EN18_13705 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EN18_13710 ENOG4105X6C Flagellar basal body-associated protein FliL EN18_13725 ENOG4108JIR Flagellum-specific ATP synthase EN18_13730 ENOG4105W2B Flagellar assembly protein EN18_13735 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EN18_13740 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) EN18_13745 ENOG4105VQ0 flagellar hook-basal body complex protein fliE EN18_13750 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EN18_13755 ENOG4105BZU Histidine kinase EN18_13760 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EN18_13765 ENOG4105MQ3 flagellar protein FliS EN18_13775 ENOG4107W9T flagellar hook-associated EN18_13780 ENOG41063QE flagellar protein FlaG EN18_13785 ENOG4105I03 Flagellin EN18_13790 ENOG4105I03 Flagellin EN18_13795 ENOG4105I03 Flagellin EN18_13800 ENOG4105EZR dyp-type peroxidase family protein EN18_13805 ENOG4105QZU Inner membrane protein YfeZ EN18_13820 ENOG4105KUZ arsenate reductase EN18_13825 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) EN18_13840 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) EN18_13845 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EN18_13855 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EN18_13860 ENOG4105C8Q Methyl-accepting chemotaxis EN18_13875 ENOG4105ERG peptidase m48, ste24p EN18_13880 ENOG4105K89 arsenate reductase EN18_13885 ENOG4105CS1 NAD(P)H quinone oxidoreductase EN18_13900 ENOG4105C2W permease EN18_13905 ENOG4108Z66 YbaK ebsC protein EN18_13910 ENOG4105CGH 5'-nucleotidase EN18_13915 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase EN18_13920 ENOG41063JG Transcriptional regulator EN18_13925 ENOG4108YY7 Invasion gene expression up-regulator SirB EN18_13930 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EN18_13935 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) EN18_13940 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) EN18_13945 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) EN18_13950 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) EN18_13955 ENOG4105C5T Phosphoribosyl pyrophosphate synthase EN18_13960 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) EN18_13965 ENOG4105C3G gtp-binding protein EN18_14050 ENOG4105I03 Flagellin EN18_14055 ENOG4105I03 Flagellin EN18_14070 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj EN18_14075 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) EN18_14080 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) EN18_14085 ENOG4105CGA flagellar basal-body rod protein FlgG EN18_14090 ENOG4108KPB Flagellar basal-body rod protein FlgF EN18_14095 ENOG4105BZE flagellar hook protein, FlgE EN18_14100 ENOG4105W00 Flagellar hook capping protein EN18_14105 ENOG4108ZC9 flagellar basal-body rod protein flgc EN18_14110 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) EN18_14115 ENOG4105BZU Histidine kinase EN18_14120 ENOG4107R88 Chemotaxis protein (CheV) EN18_14155 ENOG4105C0W non-ribosomal peptide synthetase EN18_14160 ENOG4105Q26 Siderophore-interacting protein EN18_14165 ENOG4107RBR Receptor EN18_14175 ENOG4105UYK outer membrane protein a EN18_14180 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) EN18_14185 ENOG4105C59 p-type ATPase EN18_14195 ENOG4105E2D ec 3.2.1.52 EN18_14200 ENOG4105MBR gumn family EN18_14215 ENOG4108DG9 Smr protein MutS2 EN18_14220 ENOG4105FE9 pseudouridine synthase EN18_14225 ENOG4105BZU Histidine kinase EN18_14230 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) EN18_14235 ENOG4105CXB phosphoribosylaminoimidazole synthetase EN18_14240 ENOG4108V3E phosphoribosylglycinamide formyltransferase EN18_14245 ENOG4105E7A Glutamine amidotransferase EN18_14250 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) EN18_14255 ENOG4107QPN acyl-Coa dehydrogenase EN18_14265 ENOG4108JDX DNA polymerase iii, epsilon subunit EN18_14270 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EN18_14275 ENOG4105D1A Methyltransferase EN18_14280 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) EN18_14285 ENOG4105E9H Lytic Murein transglycosylase EN18_14295 ENOG4108YZA Nitrogen regulatory protein pii EN18_14300 ENOG4105PY6 Phenolic acid decarboxylase EN18_14305 ENOG4105N7H Cytochrome EN18_14310 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) EN18_14315 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) EN18_14320 ENOG4105C0B DNA polymerase III (alpha subunit) EN18_14325 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EN18_14330 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EN18_14335 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EN18_14340 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) EN18_14345 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EN18_14350 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) EN18_14360 ENOG4105DZP Membrane-associated zinc metalloprotease EN18_14365 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) EN18_14370 ENOG4105KNE Phosphatidate cytidylyltransferase EN18_14375 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) EN18_14380 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) EN18_14385 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) EN18_14390 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) EN18_14395 ENOG4105CE9 30S ribosomal protein S2 EN18_14400 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) EN18_14405 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) EN18_14410 ENOG4108T8E UPF0325 protein EN18_14415 ENOG4108ZAI phosphatidylglycerophosphatase a EN18_14420 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) EN18_14425 ENOG4107YIM Involved in the transcription termination process (By similarity) EN18_14430 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) EN18_14445 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) EN18_14450 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) EN18_14455 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) EN18_14460 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) EN18_14465 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) EN18_14475 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) EN18_14480 ENOG4105C7N Xanthine uracil vitamin C permease EN18_14485 ENOG4105CIN aminoacyl-histidine dipeptidase EN18_14490 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) EN18_14495 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) EN18_14505 ENOG4105C8J )-transporter EN18_14510 ENOG4105BZU Histidine kinase EN18_14535 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EN18_14545 ENOG4105CJ2 (LipO)protein EN18_14550 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) EN18_14555 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) EN18_14560 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) EN18_14565 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) EN18_14570 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) EN18_14575 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) EN18_14580 ENOG4105M85 Bola protein EN18_14585 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) EN18_14595 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) EN18_14600 ENOG4105EYM Major Facilitator superfamily EN18_14610 ENOG4105K6V RNA polymerase EN18_14620 ENOG4105DRB nucleoside-specific channel-forming protein EN18_14625 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) EN18_14630 ENOG4107S0N DJ-1 family EN18_14635 ENOG4105C9B Cysteine desulfurase EN18_14640 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) EN18_14645 ENOG4105CUZ uba thif-type nad fad binding protein EN18_14650 ENOG4105CA3 membrane-bound lytic murein transglycosylase EN18_14660 ENOG4107QZM n-acetylglutamate synthase EN18_14675 ENOG4107QYX exodeoxyribonuclease v alpha EN18_14680 ENOG4107QKA exodeoxyribonuclease V beta EN18_14685 ENOG4105DSY exodeoxyribonuclease V, gamma EN18_14700 ENOG4105X2V dna damage-inducible protein EN18_14705 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) EN18_14715 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) EN18_14725 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) EN18_14740 ENOG4108Y51 tRNA-binding protein EN18_14745 ENOG41060NJ transcriptional regulator EN18_14750 ENOG4105CNT hydrolase family 2 EN18_14760 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase EN18_14765 ENOG4108IQE Amp-dependent synthetase and ligase EN18_14770 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) EN18_14775 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) EN18_14785 ENOG4105EAC phosphoserine phosphatase EN18_14795 ENOG4105D3A purine nucleoside phosphorylase DeoD-type EN18_14800 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) EN18_14805 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) EN18_14810 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) EN18_14815 ENOG4105D9N nucleoside EN18_14820 ENOG4105EYA deoxyribonuclease EN18_14830 ENOG4105BZG amino acid carrier protein EN18_14845 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) EN18_14850 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) EN18_14855 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) EN18_14860 ENOG4105D98 threonine synthase EN18_14865 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) EN18_14880 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) EN18_14890 ENOG41065U4 response regulator EN18_14895 ENOG4105BZU Histidine kinase EN18_14905 ENOG4105N5T Radical SAM Protein EN18_14920 ENOG4105CBC glutamate synthase EN18_14925 ENOG4105BZ8 glutamate synthase EN18_14935 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) EN18_14945 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) EN18_14950 ENOG4105EN6 Membrane EN18_14955 ENOG4105VP0 transcriptional regulator, lysR family EN18_14960 ENOG4105EJ9 Membrane EN18_14965 ENOG4107RRE RNA-directed DNA polymerase EN18_14990 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain EN18_14995 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain EN18_15005 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) EN18_15010 ENOG4105M6F mutator MutT protein EN18_15015 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving EN18_15025 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EN18_15030 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) EN18_15035 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) EN18_15040 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) EN18_15045 ENOG4105DFU Cell wall formation (By similarity) EN18_15050 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) EN18_15060 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) EN18_15065 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) EN18_15070 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) EN18_15075 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) EN18_15080 ENOG4105CJN penicillin-binding protein EN18_15085 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) EN18_15090 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) EN18_15095 ENOG4107QN2 dihydrolipoyl dehydrogenase EN18_15100 ENOG4107QSN dihydrolipoamide acetyltransferase EN18_15105 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) EN18_15110 ENOG41073TP transcriptional regulator EN18_15115 ENOG4105CGH 5'-nucleotidase EN18_15120 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) EN18_15125 ENOG4105T95 Thiol disulfide interChange protein EN18_15130 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EN18_15135 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) EN18_15145 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase EN18_15155 ENOG4107QHF type ii secretion system protein e EN18_15160 ENOG4105D7Q type ii secretion system EN18_15165 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) EN18_15170 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) EN18_15175 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) EN18_15185 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) EN18_15190 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EN18_15195 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EN18_15200 ENOG4105IPS esterase EN18_15205 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) EN18_15210 ENOG4108SX3 cytoplasmic protein EN18_15215 ENOG41087AY ADP-Ribose pyrophosphatase EN18_15220 ENOG4105DFG type I secretion outer membrane protein EN18_15230 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) EN18_15235 ENOG4105C8Q Methyl-accepting chemotaxis EN18_15245 ENOG4105I7R Adenylate cyclase EN18_15250 ENOG4107IX6 phosphate transport regulator EN18_15255 ENOG4105CJ3 phosphate transporter EN18_15260 ENOG4106MWK domain protein EN18_15275 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate EN18_15280 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) EN18_15285 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) EN18_15290 ENOG4105DXN mazG family EN18_15295 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EN18_15300 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) EN18_15305 ENOG4105BZU Histidine kinase EN18_15310 ENOG4108K0B C-di-gmp phosphodiesterase EN18_15325 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) EN18_15330 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) EN18_15335 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) EN18_15340 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) EN18_15345 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) EN18_15350 ENOG4105C3F Signal peptidase i EN18_15355 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) EN18_15360 ENOG4105WMJ Positive regulator of sigma E, RseC MucC EN18_15365 ENOG4105VQK sigma E regulatory protein, MucB RseB EN18_15375 ENOG4105EMN RNA polymerase sigma factor EN18_15380 ENOG4108IYU L-aspartate oxidase EN18_15390 ENOG4105Y75 tpr repeat protein EN18_15395 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) EN18_15405 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family EN18_15410 ENOG4105D0A hydroxylase EN18_15420 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) EN18_15425 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase EN18_15430 ENOG4105E66 phosphoriboisomerase A EN18_15435 ENOG4108JQ1 Dehydrogenase EN18_15440 ENOG4108ZP8 Acetolactate synthase small subunit EN18_15445 ENOG4105C7K acetolactate synthase EN18_15450 ENOG4108IQE Amp-dependent synthetase and ligase EN18_15455 ENOG41064T2 transcriptional regulator, lysR family EN18_15475 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) EN18_15480 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EN18_15485 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EN18_15490 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EN18_15535 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase EN18_15550 ENOG4108K5H permease YjgP YjgQ family protein EN18_15555 ENOG4108M8S permease YjgP YjgQ family protein EN18_15560 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) EN18_15565 ENOG4105MYG DNA polymerase iii, chi subunit EN18_15570 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) EN18_15575 ENOG4105C5I Dehydrogenase EN18_15580 ENOG4105D3G Pseudouridine synthase EN18_15585 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) EN18_15595 ENOG4108IAB Phoh family EN18_15600 ENOG4105DBV ornithine carbamoyltransferase EN18_15610 ENOG4105CXT aspartate transcarbamylase EN18_15615 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) EN18_15620 ENOG4105KME endoribonuclease L-psp EN18_15625 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase EN18_15630 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EN18_15635 ENOG4105VFK BolA family EN18_15645 ENOG4105E3I toluene tolerance EN18_15650 ENOG4107PE3 Mammalian cell entry related domain protein EN18_15655 ENOG4105CY3 ABC transporter, permease EN18_15660 ENOG4105DHJ ABC, transporter EN18_15670 ENOG4105C2X Arabinose 5-phosphate isomerase EN18_15675 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase EN18_15685 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA EN18_15690 ENOG4108IUZ ABC transporter EN18_15695 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EN18_15700 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA EN18_15705 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN EN18_15710 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) EN18_15715 ENOG41080Z8 PHOSPHOCARRIER protein EN18_15720 ENOG4105CJW magnesium transporter EN18_15725 ENOG4105CMS peptidase U62, modulator of DNA gyrase EN18_15730 ENOG4105N42 UPF0307 protein EN18_15735 ENOG4107T0D ABC, transporter EN18_15740 ENOG4106SMU thiamine transporter membrane protein EN18_15745 ENOG4105DP9 ABC transporter EN18_15750 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase EN18_15755 ENOG4105DFU Cell wall formation (By similarity) EN18_15760 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 EN18_15765 ENOG4105F0N pyrophosphate phospho-hydrolase EN18_15770 ENOG41066HZ AIG2-like family EN18_15780 ENOG4105CFU surface antigen EN18_15785 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) EN18_15790 ENOG4108UUE Transcriptional regulator EN18_15805 ENOG4105C19 ABC transporter EN18_15825 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) EN18_15830 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) EN18_15835 ENOG4105C11 sulfate adenylyltransferase), subunit 2 EN18_15840 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) EN18_15845 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic EN18_15855 ENOG4105C1J atp-dependent rna helicase EN18_15860 ENOG4107YB6 acetyltransferase, (GNAT) family EN18_15865 ENOG4108SXK Transporter Drug Metabolite Exporter family EN18_15870 ENOG4108UBT opacity-associated protein EN18_15875 ENOG4108V1T peptidylprolyl cis-trans isomerase EN18_15885 ENOG4108ZT0 50S ribosomal protein l17 EN18_15890 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EN18_15895 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) EN18_15900 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) EN18_15905 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits EN18_15915 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) EN18_15920 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) EN18_15925 ENOG4105VPB 50S ribosomal protein L30 EN18_15930 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) EN18_15935 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) EN18_15940 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) EN18_15945 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) EN18_15950 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) EN18_15955 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits EN18_15960 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) EN18_15965 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) EN18_15970 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal EN18_15975 ENOG41083MP 50s ribosomal protein l29 EN18_15980 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) EN18_15985 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) EN18_15990 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) EN18_15995 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) EN18_16000 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity EN18_16005 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) EN18_16010 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) EN18_16015 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) EN18_16020 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) EN18_16025 ENOG4105C2N RNA methyltransferase TrmH family group 3 EN18_16030 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) EN18_16035 ENOG4105E68 Sulfatase EN18_16040 ENOG4108UV7 flagellar protein motX EN18_16045 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis EN18_16050 ENOG4105D44 asparaginase EN18_16055 ENOG4108YZY peptidylprolyl cis-trans isomerase EN18_16070 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein EN18_16075 ENOG4105C5H ABC transporter EN18_16085 ENOG4105DNZ Alpha Beta Hydrolase EN18_16095 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) EN18_16100 ENOG4107RYR Transcriptional regulator, Crp Fnr family EN18_16110 ENOG4105C26 Dehydrogenase EN18_16120 ENOG4105C8Y Acetylornithine aminotransferase EN18_16125 ENOG4105DDQ anthranilate synthase EN18_16130 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) EN18_16145 ENOG4105C31 Tryptophanyl-tRNA synthetase EN18_16150 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) EN18_16155 ENOG4105DJV ribulose-phosphate 3-epimerase EN18_16160 ENOG4105DFE Dna adenine methylase EN18_16170 ENOG4105D49 3-dehydroquinate synthase EN18_16175 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) EN18_16180 ENOG4105E4G Type IV pilus EN18_16205 ENOG4108JQC penicillin-binding protein 1A EN18_16215 ENOG4105EHV domain protein EN18_16220 ENOG4107QN2 dihydrolipoyl dehydrogenase EN18_16230 ENOG4105CH7 arginosuccinase EN18_16235 ENOG4105CDH Citrulline--aspartate ligase EN18_16240 ENOG4105CAS nag kinase EN18_16245 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase EN18_16250 ENOG4105CWC Acetylornithine deacetylase EN18_16255 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) EN18_16265 ENOG4105D7W serine acetyltransferase EN18_16270 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase EN18_16275 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) EN18_16280 ENOG4107YZP Rhodanese domain protein EN18_16285 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) EN18_16295 ENOG4105E33 succinate dehydrogenase EN18_16300 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) EN18_16305 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) EN18_16310 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) EN18_16315 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein EN18_16325 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) EN18_16330 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) EN18_16355 ENOG4105CP7 Triose-phosphate isomerase EN18_16365 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) EN18_16370 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase EN18_16375 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) EN18_16380 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) EN18_16385 ENOG41063M6 Cell Division Protein EN18_16390 ENOG4105ETE Transcriptional regulator (LacI family EN18_16395 ENOG4105C25 Primosomal protein n' EN18_16400 ENOG4105VFB Binds the 23S rRNA (By similarity) EN18_16405 ENOG4105C6K Malic enzyme EN18_16410 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) EN18_16415 ENOG4105C28 cystathionine EN18_16420 ENOG4105CFH Aspartokinase EN18_16430 ENOG4105SYT Methylenetetrahydrofolate reductase EN18_16435 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) EN18_16440 ENOG4105CBT Fructose-1,6-bisphosphatase EN18_16445 ENOG4105CTQ phosphohexokinase EN18_16450 ENOG41076HS cation diffusion facilitator family transporter EN18_16460 ENOG4105E3W Two component transcriptional regulator (Winged helix family EN18_16465 ENOG4105E0F Histidine kinase EN18_16475 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) EN18_16480 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 EN18_16485 ENOG4105BZU Histidine kinase EN18_16490 ENOG4108IJ0 Aspartate ammonia-lyase EN18_16495 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter EN18_16510 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) EN18_16520 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) EN18_16530 ENOG4107QN1 sodium solute EN18_16535 ENOG4105EX9 Membrane EN18_16540 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) EN18_16545 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) EN18_16550 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EN18_16555 ENOG4105CB5 ATP-dependent DNA helicase recG EN18_16560 ENOG4105C2W permease EN18_16565 ENOG4105E0F Histidine kinase EN18_16570 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EN18_16575 ENOG4108RRZ Transcription elongation factor GreB EN18_16580 ENOG4105BZM domain protein EN18_16590 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) EN18_16595 ENOG4105MJ2 Competence protein EN18_16600 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) EN18_16605 ENOG4107RK2 ADP-ribose diphosphatase NudE EN18_16610 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase EN18_16615 ENOG4105PIC general secretion pathway protein N EN18_16620 ENOG4105U1E general secretion pathway protein M EN18_16625 ENOG4108BY5 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) EN18_16630 ENOG4108RTD type II secretion system protein K EN18_16635 ENOG4108WWZ General secretion pathway protein J EN18_16640 ENOG4105X5Z General secretion pathway protein I EN18_16645 ENOG4105VWV general secretion pathway protein h EN18_16650 ENOG4108VAU general secretion pathway protein G EN18_16655 ENOG4105D7Q type ii secretion system EN18_16660 ENOG4107QHF type ii secretion system protein e EN18_16670 ENOG4108XKW General secretion pathway protein C EN18_16675 ENOG4105VEJ Heat shock protein EN18_16680 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) EN18_16685 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase EN18_16695 ENOG4105SUU thioesterase domain EN18_16700 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) EN18_16725 ENOG4105C5F glutamine synthetase EN18_16740 ENOG4105CUX Signal transduction histidine kinase EN18_16745 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EN18_16750 ENOG4105BZU Histidine kinase EN18_16755 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) EN18_16790 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) EN18_16795 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin EN18_16800 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) EN18_16805 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) EN18_16820 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) EN18_16825 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EN18_16830 ENOG4105CRP Part of the ABC transporter FtsEX involved in EN18_16835 ENOG4105CAK Cell division ATP-binding protein ftsE EN18_16840 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) EN18_16845 ENOG4106H78 methyltransferase EN18_16880 ENOG4108RMU ferritin dps family protein EN18_16885 ENOG4105D58 Diguanylate phosphodiesterase EN18_16890 ENOG410829K Lysine exporter protein (Lyse ygga) EN18_16895 ENOG4108EUD Lysophospholipase EN18_16900 ENOG4105DQF Hydrolase EN18_16915 ENOG4105BZU Histidine kinase EN18_16920 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant EN18_16925 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EN18_16930 ENOG4105CT0 Protein of unknown function, DUF484 EN18_16935 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) EN18_16940 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) EN18_16950 ENOG4105XQ6 frataxin-like protein EN18_16955 ENOG4107T0K Adenylate cyclase EN18_16965 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) EN18_16970 ENOG41076E6 Uroporphyrinogen-III Synthase EN18_16975 ENOG4105ECF c-methyltransferase EN18_16980 ENOG410601J HemY protein EN18_16985 ENOG4105D4P Coproporphyrinogen iii oxidase EN18_16990 ENOG4105XCT Protein of unknown function (DUF2489) EN18_16995 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) EN18_17005 ENOG4106RE7 Cytochrome EN18_17010 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) EN18_17015 ENOG4105C2M dna polymerase I EN18_17025 ENOG4105D52 delta-aminolevulinic acid dehydratase EN18_17030 ENOG4105F8V Hydrolase, tatD family EN18_17035 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) EN18_17050 ENOG4105C8Q Methyl-accepting chemotaxis EN18_17055 ENOG4105X6C Flagellar basal body-associated protein FliL EN18_17060 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) EN18_17065 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) EN18_17070 ENOG4105E55 glycerol-3-phosphate acyltransferase EN18_17075 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) EN18_17085 ENOG4107R73 Mate efflux family protein EN18_17090 ENOG4105CA0 peroxidase EN18_17095 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) EN18_17100 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) EN18_17105 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) EN18_17110 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) EN18_17115 ENOG4105JC1 sterol-binding domain protein EN18_17120 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EN18_17125 ENOG4105CGY Dna recombination protein EN18_17135 ENOG4105CBX hi0933 family EN18_17140 ENOG4108V6B universal stress protein B EN18_17145 ENOG41090A1 ferritin EN18_17150 ENOG4108M6U Universal stress protein A EN18_17155 ENOG4105EMK carboxylate amino acid amine transporter EN18_17165 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) EN18_17170 ENOG4105BZU Histidine kinase EN18_17175 ENOG4108VVK transcriptional Regulator, AsnC EN18_17185 ENOG4105CNH Multidrug resistance protein MdtL EN18_17195 ENOG4105DC7 peptidase M24 EN18_17195 ENOG4105DC7 peptidase M24 EN18_17200 ENOG4105D41 biosynthesis protein thiH EN18_17205 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) EN18_17210 ENOG4105WHD thiamine biosynthesis protein ThiS EN18_17215 ENOG4105D06 uba thif-type nad fad binding protein EN18_17225 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) EN18_17230 ENOG4105WMR Protein CrcB homolog EN18_17270 ENOG4108Z0R Transferase EN18_17280 ENOG4105E2X shikimate dehydrogenase EN18_17285 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) EN18_17290 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EN18_17295 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) EN18_17300 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit EN18_17305 ENOG4108WI1 Dna topoisomerase EN18_17310 ENOG4108RPN Protein smg homolog EN18_17315 ENOG4105C79 DNA protecting protein DprA EN18_17320 ENOG4108WZM domain protein EN18_17325 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EN18_17330 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) EN18_17335 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B EN18_17340 ENOG4105C1A potassium transporter peripheral membrane EN18_17345 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) EN18_17355 ENOG4108UT2 hemolysin iii EN18_17360 ENOG4108N23 SpoOM-related protein EN18_17370 ENOG4105PC1 Conserved Protein EN18_17380 ENOG4105E27 serine threonine protein kinase EN18_17385 ENOG4108Z33 Thiol disulfide Interchange Protein EN18_17390 ENOG4106HNH Acyl-transferase EN18_17395 ENOG4105C0P Mg chelatase subunit ChlI EN18_17410 ENOG4105CM2 brancheD-chain amino acid aminotransferase EN18_17415 ENOG4105C01 Dihydroxy-acid dehydratase EN18_17420 ENOG4105C7B Threonine dehydratase EN18_17425 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family EN18_17435 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) EN18_17450 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit EN18_17455 ENOG4105C38 Glycyl-tRNA synthetase beta subunit EN18_17460 ENOG4105JKW Valine--pyruvate aminotransferase EN18_17465 ENOG4108ZNX Heat shock protein EN18_17480 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EN18_17485 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) EN18_17490 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) EN18_17495 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) EN18_17500 ENOG4105EAB amino acid AbC transporter EN18_17505 ENOG4105E5Q amino acid AbC transporter EN18_17520 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) EN18_17525 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins EN18_17530 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) EN18_17535 ENOG4105QTB Flavodoxin EN18_17540 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) EN18_17545 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) EN18_17550 ENOG4107QJE Chromosome Partitioning Protein EN18_17555 ENOG4105FA0 parb-like partition protein EN18_17560 ENOG410684E atp synthase EN18_17565 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) EN18_17570 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) EN18_17575 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) EN18_17580 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) EN18_17585 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) EN18_17590 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) EN18_17595 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) EN18_17600 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) EN18_17605 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) EN18_17610 ENOG4105CZQ inner membrane transport protein YdhC EN18_17615 ENOG4105F52 Transcriptional regulator EN18_17620 ENOG4105CHU acetyl-coa acetyltransferase EN18_17625 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EN18_17630 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein EN18_17635 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) EN18_17640 ENOG4108RR8 protoporphyrinogen oxidase EN18_17685 ENOG4105EMY transcriptional regulator EN18_17690 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase EN18_17695 ENOG4105W0Z cytoplasmic protein EN18_17700 ENOG4105BZS acriflavin resistance protein EN18_17705 ENOG410624X efflux transporter, rnd family, mfp subunit EN18_17710 ENOG4105Y7M Transcriptional regulator, TetR family EN18_17715 ENOG4105C4R Atp-dependent dna helicase EN18_17720 ENOG4105MPD Cytochrome EN18_17760 ENOG4105DEF Extracellular solute-binding protein, family 5 EN18_17765 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EN18_17770 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EN18_17780 ENOG4108UK2 deaminase EN18_17810 ENOG4108ZXE EN18_17845 ENOG4105DC8 reductase EN18_17850 ENOG4105D6S protein involved in catabolism of external DNA EN18_17855 ENOG4105DGW oligopeptidase A EN18_17860 ENOG4105C4R Atp-dependent dna helicase EN18_17870 ENOG4108DMH HTH_ARAC EN18_17880 ENOG4105FR1 rard protein EN18_17885 ENOG4105C9U ATP-dependent DNA helicase RecQ EN18_17900 ENOG4105BZ1 (ABC) transporter EN18_17905 ENOG4105E0K tonB-dependent siderophore receptor EN18_17910 ENOG4105E0A ABC, transporter EN18_17915 ENOG4105J76 Periplasmic binding protein EN18_17920 ENOG4105S6R Iron-hydroxamate transporter permease subunit EN18_17925 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) EN18_17930 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate EN18_17935 ENOG4105C5Y PTS System EN18_17945 ENOG4105DSJ YicC domain protein EN18_17950 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) EN18_17955 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) EN18_17960 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase EN18_17965 ENOG4105D1S lipid A biosynthesis EN18_17970 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) EN18_17975 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase EN18_17980 ENOG4105C8Q Methyl-accepting chemotaxis EN18_17990 ENOG4105KDC 50s ribosomal protein l28 EN18_17995 ENOG4105W0E 50S ribosomal protein L33 EN18_18005 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) EN18_18010 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) EN18_18015 ENOG4105M5K heptosyltransferase EN18_18020 ENOG4106WTF Glycosyl transferase, family 2 EN18_18025 ENOG4105DKP glycosyl transferase, family 9 EN18_18030 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) EN18_18060 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase EN18_18065 ENOG4108ST3 glycosyltransferase EN18_18075 ENOG4105XA0 heptosyltransferase ii EN18_18090 ENOG4107T94 Endo-14-beta-xylanase EN18_18095 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) EN18_18100 ENOG4105CJT Mannose-1-phosphate guanylyltransferase EN18_18105 ENOG4107QKV phosphomannomutase EN18_18110 ENOG4105C0K Gdp-mannose 4,6-dehydratase EN18_18115 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase EN18_18130 ENOG4105EY8 ABC transporter EN18_18140 ENOG4105CEY Amp-dependent synthetase and ligase EN18_18145 ENOG4108EKI Dehydrogenase EN18_18155 ENOG4108UT6 Transferase hexapeptide repeat containing protein EN18_18160 ENOG410600T transposase EN18_18190 ENOG4105D3Q Sugar transferase EN18_18195 ENOG4105CY0 Metallo-Beta-Lactamase EN18_18200 ENOG4105CUY Mechanosensitive ion channel EN18_18205 ENOG4108RG0 uracil-dna glycosylase EN18_18210 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase EN18_18215 ENOG4105R2J Conserved Protein EN18_18220 ENOG4105EIP mannose-6-phosphate isomerase EN18_18225 ENOG4105DKQ ROK family EN18_18235 ENOG4105K70 DNA-binding protein EN18_18245 ENOG4105C12 Phosphoribosylglycinamide synthetase EN18_18250 ENOG4105DC1 bifunctional purine biosynthesis protein purh EN18_18260 ENOG4105W1Y Transcriptional regulator EN18_18265 ENOG4108M3R transcriptional activator CadC EN18_18270 ENOG4105D5Q Arginine ornithine antiporter EN18_18275 ENOG4105CXN decarboxylase EN18_18280 ENOG4105C8Q Methyl-accepting chemotaxis EN18_18295 ENOG4105E0K tonB-dependent siderophore receptor EN18_18300 ENOG4108UHU Aldolase EN18_18305 ENOG4105C6Z Gluconate EN18_18310 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family EN18_18315 ENOG4105C01 Dihydroxy-acid dehydratase EN18_18320 ENOG4105DIQ Transcriptional regulator EN18_18325 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) EN18_18330 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) EN18_18335 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) EN18_18340 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EN18_18345 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein EN18_18350 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) EN18_18355 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EN18_18370 ENOG4105D8G Major Facilitator superfamily EN18_18375 ENOG4105BZU Histidine kinase EN18_18380 ENOG4105C9X ppx gppa phosphatase EN18_18385 ENOG4105C1J atp-dependent rna helicase EN18_18390 ENOG4105K63 Thioredoxin EN18_18395 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) EN18_18405 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) EN18_18415 ENOG4107QK7 reductase EN18_18450 ENOG4105JIM Phosphatidylserine synthase EN18_18460 ENOG4105D4A Cell wall formation (By similarity) EN18_18465 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase EN18_18470 ENOG4105CS9 pantothenic acid kinase EN18_18495 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) EN18_18500 ENOG4105PM1 preprotein translocase subunit SecE EN18_18505 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) EN18_18510 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) EN18_18515 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) EN18_18520 ENOG4108VZM 50s ribosomal protein L10 EN18_18525 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) EN18_18530 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EN18_18535 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EN18_18540 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor EN18_18545 ENOG4105E09 nadh pyrophosphatase EN18_18550 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) EN18_18555 ENOG41062JF Transcriptional regulator EN18_18565 ENOG41063SB peptidase EN18_18570 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) EN18_18580 ENOG4105C8P )-transporter EN18_18585 ENOG4105DJ4 phosphatidylserine decarboxylase EN18_18590 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) EN18_18595 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) EN18_18645 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) EN18_18650 ENOG4105K8N protein family UPF0079, ATPase EN18_18655 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EN18_18660 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) EN18_18665 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) EN18_18670 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) EN18_18675 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) EN18_18680 ENOG4107QJR hflk protein EN18_18685 ENOG4105EPW hflc protein EN18_18695 ENOG41069P5 Protein slyX homolog EN18_18705 ENOG4108V1T peptidylprolyl cis-trans isomerase EN18_18710 ENOG4105WWK YheO domain protein EN18_18715 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) EN18_18720 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) EN18_18730 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) EN18_18735 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) EN18_18740 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) EN18_18745 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) EN18_18750 ENOG4105W53 bacterioferritin-associated ferredoxin EN18_18755 ENOG4108UQY Iron-storage protein EN18_18760 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) EN18_18765 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) EN18_18770 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) EN18_18775 ENOG4105K9Q Binds to the 23S rRNA (By similarity) EN18_18785 ENOG4105CDU Replicative dna helicase EN18_18790 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EN18_18795 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme EN18_18800 ENOG4107QP8 phosphohexose isomerase EN18_18815 ENOG4105MYN Zinc uptake regulation protein EN18_18820 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) EN18_18825 ENOG4105P4Z Phage shock protein G EN18_18840 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EN18_18845 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) EN18_18850 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) EN18_18940 ENOG4105EEQ Na H antiporter EN18_18945 ENOG4105C3R Methionine synthase EN18_18950 ENOG4105CFH Aspartokinase EN18_18955 ENOG4105C5R Aminotransferase EN18_18965 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) EN18_18970 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EN18_18975 ENOG41086KC Transcriptional regulator EN18_18980 ENOG4108UUM single-stranded DNA-binding protein EN18_18985 ENOG41062P1 Diguanylate cyclase phosphodiesterase EN18_19005 ENOG4105E4G Type IV pilus EN18_19020 ENOG4107QHF type ii secretion system protein e EN18_19025 ENOG4105D7Q type ii secretion system EN18_19035 ENOG4105X0D Fimbrial protein EN18_19070 ENOG4105DFF Rod shape-determining protein mreb EN18_19075 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) EN18_19080 ENOG4105VQ7 Rod shape-determining protein MreD EN18_19085 ENOG4108Z03 MAF-like protein EN18_19090 ENOG4105C03 ribonuclease EN18_19095 ENOG4105QD6 exported protein EN18_19105 ENOG4105D1U peptidase U62 modulator of DNA gyrase EN18_19110 ENOG4105CEU Arginine dihydrolase EN18_19130 ENOG41081QV Universal stress protein EN18_19145 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) EN18_19150 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) EN18_19155 ENOG4105D5Q Arginine ornithine antiporter EN18_19160 ENOG4105D5Q Arginine ornithine antiporter EN18_19165 ENOG4105EAH synthase EN18_19170 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) EN18_19175 ENOG4105K46 50S ribosomal protein l27 EN18_19180 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control EN18_19185 ENOG4105DWK Membrane EN18_19190 ENOG4107XM3 UPF0442 protein EN18_19200 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) EN18_19205 ENOG4105NWN ApaG protein EN18_19210 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) EN18_19215 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) EN18_19220 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) EN18_19225 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) EN18_19230 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) EN18_19285 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division EN18_19290 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) EN18_19295 ENOG4105CEN a g-specific adenine glycosylase EN18_19300 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) EN18_19305 ENOG4105CSV Glutaminase EN18_19310 ENOG4105CSA Coproporphyrinogen iii oxidase EN18_19315 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) EN18_19325 ENOG4105VZ9 UPF0235 protein EN18_19330 ENOG4108VIA integral membrane protein EN18_19335 ENOG4105II7 pyrroline-5-carboxylate reductase EN18_19340 ENOG4105DFA alanine racemase domain protein EN18_19345 ENOG4105CZX twitching motility protein EN18_19350 ENOG4105CZX twitching motility protein EN18_19360 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) EN18_19365 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) EN18_19370 ENOG4108UJU UPF0301 protein EN18_19375 ENOG4105D7Z glutathione synthase EN18_19380 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) EN18_19385 ENOG4105RWS endonuclease I EN18_19390 ENOG4105GPY SprT protein EN18_19395 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP EN18_19405 ENOG4105CV1 Transketolase (EC 2.2.1.1) EN18_19410 ENOG4108R4R Iron-regulated virulence regulatory protein EN18_19415 ENOG4105D05 Receptor EN18_19420 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EN18_19425 ENOG4105BZA Phosphoglycerate kinase EN18_19435 ENOG4105D2N Aldolase EN18_19445 ENOG4105D64 Mechanosensitive ion channel EN18_19450 ENOG4108ZUB Lysine exporter protein (Lyse ygga) EN18_19455 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) EN18_19460 ENOG4105MPN Membrane EN18_19465 ENOG4105CA9 Pyruvate kinase EN18_19470 ENOG410804X Transcriptional regulator EN18_19475 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EN18_19480 ENOG4105CH5 extracellular solute-binding protein, family 7 EN18_19535 ENOG4105C8Q Methyl-accepting chemotaxis EN18_19540 ENOG4105D58 Diguanylate phosphodiesterase EN18_19545 ENOG4105DFP Integrase EN18_19555 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EN18_19560 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) EN18_19565 ENOG4105KTH gatB Yqey EN18_19570 ENOG4105VCC 30S ribosomal protein S21 EN18_19575 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EN18_19585 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) EN18_19590 ENOG4107ZVW dihydroneopterin aldolase EN18_19595 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase EN18_19600 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) EN18_19610 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) EN18_19615 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) EN18_19620 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) EN18_19625 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) EN18_19630 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) EN18_19635 ENOG4108K5P (LipO)protein EN18_19640 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EN18_19645 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) EN18_19650 ENOG4105C6T cysteine synthase EN18_19655 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein EN18_19660 ENOG4108I5D sulfate abc transporter EN18_19665 ENOG4105ECW sulfate abc transporter EN18_19670 ENOG4108IJ6 ABC transporter EN18_19680 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) EN18_19685 ENOG4105Y3E Modulates RecA activity (By similarity) EN18_19690 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) EN18_19695 ENOG4105CFH Aspartokinase EN18_19700 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) EN18_19755 ENOG4107QSA Oxaloacetate decarboxylase EN18_19760 ENOG4105D9Q decarboxylase (Beta subunit) EN18_19770 ENOG4105W39 Membrane EN18_19780 ENOG4105D9M gamma-glutamylcysteine synthetase EN18_19785 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) EN18_19790 ENOG4108JU6 CBS domain protein EN18_19795 ENOG4106KVJ cytochrome C assembly protein EN18_19800 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY EN18_19805 ENOG4105K5M 30s ribosomal protein S16 EN18_19810 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) EN18_19815 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) EN18_19820 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) EN18_19825 ENOG4105C0H protease EN18_19830 ENOG4105C0H protease EN18_19840 ENOG4105D6Z AFG1 family ATPase EN18_19845 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) EN18_19850 ENOG4108UJD 30S ribosomal protein S9 EN18_19855 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) EN18_19860 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) EN18_19865 ENOG4105EIX cytochrome c1 EN18_19870 ENOG4107MKT Stringent starvation protein a EN18_19875 ENOG4105KB2 stringent starvation protein b EN18_19880 ENOG4105W4M Transport-associated protein EN18_19885 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) EN18_19890 ENOG41082RQ UPF0102 protein EN18_19895 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) EN18_19900 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) EN18_19905 ENOG410630P Transcriptional regulator EN18_19910 ENOG4108UGV hypoxanthine phosphoribosyltransferase EN18_19915 ENOG41077A9 carbonic anhydrase EN18_19920 ENOG4105CHH sulfate transporter EN18_19925 ENOG4105DA5 (ABC) transporter EN18_19930 ENOG4105E3A (ABC) transporter EN18_19935 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)