locus-tag	class	description
EN18_00015	COG0745	RESPONSE REGULATOR receiver
EN18_00020	COG5002	protein histidine kinase activity
EN18_00050	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EN18_00065	COG2814	Major facilitator Superfamily
EN18_00080	COG1686	Belongs to the peptidase S11 family
EN18_00100	COG1943	Transposase
EN18_00105	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EN18_00105	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EN18_00110	COG0509	glycine decarboxylation via glycine cleavage system
EN18_00115	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EN18_00125	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EN18_00135	COG3039	Transposase
EN18_00160	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EN18_00170	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EN18_00175	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EN18_00210	COG1028	Short-chain dehydrogenase reductase Sdr
EN18_00250	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EN18_00275	COG0494	nUDIX hydrolase
EN18_00280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EN18_00285	COG3040	lipid binding
EN18_00310	COG3328	transposase activity
EN18_00315	COG3041	Addiction module toxin RelE StbE family
EN18_00380	COG1619	proteins homologs of microcin C7 resistance protein MccF
EN18_00425	COG0346	lactoylglutathione lyase activity
EN18_00440	COG3040	lipid binding
EN18_00455	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EN18_00460	COG1280	lysine exporter protein (LysE YggA)
EN18_00625	COG3549	Plasmid maintenance system killer
EN18_00630	COG3093	addiction module antidote protein HigA
EN18_00645	COG1619	proteins homologs of microcin C7 resistance protein MccF
EN18_00665	COG3040	lipid binding
EN18_00730	COG4977	sequence-specific DNA binding
EN18_00775	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
EN18_00780	COG2944	sequence-specific DNA binding
EN18_00795	COG3039	Transposase
EN18_00815	COG0346	lactoylglutathione lyase activity
EN18_00900	COG1943	Transposase
EN18_00960	COG0346	lactoylglutathione lyase activity
EN18_00985	COG1328	CTP reductase activity
EN18_00990	COG0602	queuosine metabolic process
EN18_01000	COG4067	protein conserved in archaea
EN18_01000	COG0189	ligase activity
EN18_01005	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EN18_01005	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EN18_01005	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
EN18_01010	COG1105	Belongs to the carbohydrate kinase PfkB family
EN18_01015	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EN18_01015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EN18_01020	COG1609	Transcriptional regulator
EN18_01025	COG0420	3'-5' exonuclease activity
EN18_01030	COG0419	ATPase involved in DNA repair
EN18_01035	COG0784	Response regulator, receiver
EN18_01035	COG2205	protein histidine kinase activity
EN18_01040	COG0156	8-amino-7-oxononanoate synthase activity
EN18_01050	COG0038	chloride channel
EN18_01055	COG0523	cobalamin synthesis protein
EN18_01065	COG3158	transport of potassium into the cell
EN18_01070	COG1013	pyruvate-flavodoxin oxidoreductase activity
EN18_01070	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EN18_01070	COG0674	pyruvate-flavodoxin oxidoreductase activity
EN18_01070	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EN18_01075	COG2205	protein histidine kinase activity
EN18_01080	COG0745	RESPONSE REGULATOR receiver
EN18_01085	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EN18_01090	COG0586	Pfam SNARE associated Golgi protein
EN18_01100	COG2200	EAL domain
EN18_01110	COG3038	cytochrome b561
EN18_01120	COG2116	formate transmembrane transporter activity
EN18_01130	COG0583	DNA-binding transcription factor activity
EN18_01140	COG3593	DNA synthesis involved in DNA repair
EN18_01145	COG0737	Belongs to the 5'-nucleotidase family
EN18_01160	COG2824	Alkylphosphonate utilization operon protein PhnA
EN18_01215	COG3706	GGDEF domain
EN18_01230	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EN18_01235	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EN18_01245	COG0745	RESPONSE REGULATOR receiver
EN18_01270	COG0023	Translation Initiation Factor
EN18_01280	COG1181	Belongs to the D-alanine--D-alanine ligase family
EN18_01290	COG0045	succinate-CoA ligase (ADP-forming) activity
EN18_01290	COG1042	CoA-binding domain protein
EN18_01290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EN18_01295	COG0583	DNA-binding transcription factor activity
EN18_01300	COG4771	TonB-dependent receptor
EN18_01300	COG1629	transport
EN18_01315	COG2050	protein possibly involved in aromatic compounds catabolism
EN18_01335	COG0625	glutathione transferase activity
EN18_01350	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EN18_01355	COG4172	Belongs to the ABC transporter superfamily
EN18_01360	COG4239	(ABC) transporter, permease
EN18_01365	COG4174	ABC transporter (Permease)
EN18_01370	COG4166	transmembrane transport
EN18_01415	COG3842	ATPase activity
EN18_01425	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EN18_01435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EN18_01440	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EN18_01445	COG1011	Hydrolase
EN18_01455	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
EN18_01460	COG1970	mechanosensitive ion channel activity
EN18_01465	COG2759	Belongs to the formate--tetrahydrofolate ligase family
EN18_01470	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EN18_01470	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EN18_01475	COG0302	gtp cyclohydrolase
EN18_01485	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EN18_01495	COG2897	thiosulfate sulfurtransferase activity
EN18_01500	COG2390	Transcriptional regulator
EN18_01510	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EN18_01515	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EN18_01540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EN18_01565	COG0583	DNA-binding transcription factor activity
EN18_01570	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
EN18_01600	COG0640	Transcriptional regulator
EN18_01610	COG0446	pyridine nucleotide-disulphide oxidoreductase
EN18_01655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EN18_01655	COG1263	PTS System
EN18_01665	COG1621	beta-fructofuranosidase activity
EN18_01670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EN18_01675	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EN18_01685	COG2885	chlorophyll binding
EN18_01690	COG0545	Peptidyl-prolyl cis-trans isomerase
EN18_01695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EN18_01700	COG0840	transmembrane signaling receptor activity
EN18_01705	COG3069	C4-dicarboxylate transmembrane transporter activity
EN18_01710	COG1760	l-serine dehydratase
EN18_01730	COG1609	Transcriptional regulator
EN18_01735	COG2197	response regulator
EN18_01740	COG3850	Histidine kinase
EN18_01745	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EN18_01755	COG0243	molybdopterin cofactor binding
EN18_01775	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EN18_01780	COG2197	response regulator
EN18_01785	COG3851	Histidine kinase
EN18_01790	COG2271	Major facilitator Superfamily
EN18_01795	COG1840	ABC-type Fe3 transport system, periplasmic component
EN18_01805	COG3842	ATPase activity
EN18_01810	COG3243	poly(R)-hydroxyalkanoic acid synthase
EN18_01820	COG0183	Belongs to the thiolase family
EN18_01830	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EN18_01835	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EN18_01850	COG3706	GGDEF domain
EN18_01855	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EN18_01865	COG1979	alcohol dehydrogenase
EN18_01880	COG4191	Histidine kinase
EN18_01885	COG1840	ABC-type Fe3 transport system, periplasmic component
EN18_01890	COG2271	Major facilitator Superfamily
EN18_01895	COG0469	pyruvate kinase activity
EN18_01900	COG2198	Histidine kinase
EN18_01900	COG2205	protein histidine kinase activity
EN18_01900	COG0784	Response regulator, receiver
EN18_01905	COG1879	ABC-type sugar transport system periplasmic component
EN18_01910	COG1803	Methylglyoxal synthase
EN18_01915	COG1335	isochorismatase
EN18_01920	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EN18_01935	COG0210	DNA helicase
EN18_01940	COG1289	transmembrane transporter activity
EN18_01970	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EN18_01975	COG4149	molybdate abc transporter
EN18_01980	COG0725	ABC transporter, periplasmic molybdate-binding protein
EN18_01985	COG1492	cobalamin metabolic process
EN18_02030	COG5002	protein histidine kinase activity
EN18_02030	COG0784	Response regulator, receiver
EN18_02035	COG1879	ABC-type sugar transport system periplasmic component
EN18_02075	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EN18_02080	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EN18_02085	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EN18_02090	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
EN18_02095	COG0247	lactate metabolic process
EN18_02100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EN18_02105	COG3118	belongs to the thioredoxin family
EN18_02135	COG0583	DNA-binding transcription factor activity
EN18_02140	COG4160	amino acid transport
EN18_02145	COG4215	(ABC) transporter
EN18_02150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EN18_02155	COG1126	abc transporter atp-binding protein
EN18_02165	COG2425	protein containing a von Willebrand factor type A (vWA) domain
EN18_02175	COG0494	nUDIX hydrolase
EN18_02180	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
EN18_02190	COG1309	transcriptional regulator
EN18_02195	COG0513	Belongs to the DEAD box helicase family
EN18_02200	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
EN18_02210	COG0814	amino acid
EN18_02215	COG0840	transmembrane signaling receptor activity
EN18_02220	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EN18_02225	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EN18_02235	COG1984	allophanate hydrolase subunit 2
EN18_02250	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EN18_02255	COG4181	ATPase activity
EN18_02265	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EN18_02270	COG5001	Diguanylate cyclase
EN18_02270	COG1716	ATPase activity
EN18_02285	COG0484	heat shock protein binding
EN18_02330	COG0546	phosphoglycolate phosphatase activity
EN18_02345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EN18_02350	COG1368	sulfuric ester hydrolase activity
EN18_02360	COG0513	Belongs to the DEAD box helicase family
EN18_02365	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
EN18_02375	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EN18_02385	COG3046	protein related to deoxyribodipyrimidine photolyase
EN18_02390	COG3397	chitin binding
EN18_02395	COG3227	Zinc metalloprotease (Elastase)
EN18_02405	COG0010	Belongs to the arginase family
EN18_02410	COG1166	arginine decarboxylase activity
EN18_02420	COG2239	Acts as a magnesium transporter
EN18_02425	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EN18_02430	COG0459	protein refolding
EN18_02440	COG0527	aspartate kinase activity
EN18_02445	COG0662	Cupin 2, conserved barrel domain protein
EN18_02450	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EN18_02455	COG0456	acetyltransferase
EN18_02460	COG2154	pterin-4-alpha-carbinolamine dehydratase
EN18_02465	COG3186	Phenylalanine-4-hydroxylase
EN18_02470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EN18_02485	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EN18_02490	COG0583	DNA-binding transcription factor activity
EN18_02505	COG2171	N-acyltransferase activity
EN18_02510	COG1253	flavin adenine dinucleotide binding
EN18_02515	COG1765	OsmC-like protein
EN18_02540	COG0531	amino acid
EN18_02545	COG3706	GGDEF domain
EN18_02555	COG3279	Response regulator of the LytR AlgR family
EN18_02560	COG3275	phosphorelay sensor kinase activity
EN18_02575	COG1136	(ABC) transporter
EN18_02575	COG0577	efflux transmembrane transporter activity
EN18_02580	COG1136	(ABC) transporter
EN18_02595	COG4989	oxidoreductase activity
EN18_02600	COG0366	Alpha amylase catalytic
EN18_02615	COG2067	long-chain fatty acid transport protein
EN18_02620	COG2267	carboxylic ester hydrolase activity
EN18_02630	COG3227	Zinc metalloprotease (Elastase)
EN18_02635	COG3047	cAMP biosynthetic process
EN18_02645	COG1686	Belongs to the peptidase S11 family
EN18_02650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EN18_02655	COG1271	oxidase subunit
EN18_02660	COG1294	oxidase, subunit
EN18_02670	COG3048	D-serine ammonia-lyase activity
EN18_02675	COG0583	DNA-binding transcription factor activity
EN18_02715	COG1063	alcohol dehydrogenase
EN18_02730	COG0693	protein deglycase activity
EN18_02745	COG0346	lactoylglutathione lyase activity
EN18_02765	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EN18_02770	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EN18_02775	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EN18_02780	COG0363	glucosamine-6-phosphate deaminase activity
EN18_02785	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EN18_02810	COG1929	Belongs to the glycerate kinase type-1 family
EN18_02815	COG2610	gluconate transmembrane transporter activity
EN18_02820	COG3835	regulator
EN18_02830	COG0748	coenzyme F420 binding
EN18_02835	COG3721	Heme iron utilization protein
EN18_02845	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EN18_02850	COG0811	peptide transport
EN18_02855	COG0848	biopolymer transport protein
EN18_02860	COG4558	Periplasmic binding protein
EN18_02865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EN18_02870	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EN18_02905	COG3217	Mosc domain protein beta barrel domain protein
EN18_02905	COG3217	Mosc domain protein beta barrel domain protein
EN18_02905	COG0633	Ferredoxin
EN18_02905	COG0633	Ferredoxin
EN18_02910	COG0418	dihydroorotase activity
EN18_02920	COG3152	Membrane
EN18_02930	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EN18_02935	COG2354	Protein conserved in bacteria
EN18_02940	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EN18_02945	COG1278	Cold shock
EN18_02960	COG2207	Transcriptional regulator
EN18_02960	COG4753	response regulator
EN18_02970	COG3706	GGDEF domain
EN18_02975	COG1349	DNA-binding transcription factor activity
EN18_02990	COG3833	ABC-type maltose transport systems, permease component
EN18_02995	COG1175	transmembrane transport
EN18_03005	COG3842	ATPase activity
EN18_03010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EN18_03025	COG0393	Putative heavy-metal-binding
EN18_03030	COG2197	response regulator
EN18_03035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EN18_03040	COG0784	Response regulator, receiver
EN18_03040	COG0835	chemotaxis
EN18_03045	COG1846	Transcriptional regulator
EN18_03050	COG3706	GGDEF domain
EN18_03085	COG0583	DNA-binding transcription factor activity
EN18_03090	COG5001	Diguanylate cyclase
EN18_03105	COG1741	Belongs to the pirin family
EN18_03110	COG3123	guanosine phosphorylase activity
EN18_03120	COG2211	Major facilitator Superfamily
EN18_03130	COG0840	transmembrane signaling receptor activity
EN18_03135	COG1067	ATP-dependent peptidase activity
EN18_03145	COG4172	Belongs to the ABC transporter superfamily
EN18_03170	COG0583	DNA-binding transcription factor activity
EN18_03175	COG1620	l-lactate permease
EN18_03180	COG1304	FMN binding
EN18_03190	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EN18_03205	COG0840	transmembrane signaling receptor activity
EN18_03215	COG0513	Belongs to the DEAD box helicase family
EN18_03220	COG0583	DNA-binding transcription factor activity
EN18_03230	COG1902	pentaerythritol trinitrate reductase activity
EN18_03240	COG1132	(ABC) transporter
EN18_03250	COG1902	pentaerythritol trinitrate reductase activity
EN18_03260	COG1280	lysine exporter protein (LysE YggA)
EN18_03265	COG2207	Transcriptional regulator
EN18_03285	COG1846	Transcriptional regulator
EN18_03290	COG1764	response to oxidative stress
EN18_03295	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EN18_03300	COG0697	spore germination
EN18_03310	COG0700	Nucleoside recognition
EN18_03315	COG3366	ferrous iron transmembrane transporter activity
EN18_03320	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EN18_03330	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EN18_03335	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EN18_03340	COG2259	Doxx family
EN18_03365	COG0363	glucosamine-6-phosphate deaminase activity
EN18_03380	COG4580	involved in the transport of maltose and maltodextrins
EN18_03395	COG0840	transmembrane signaling receptor activity
EN18_03410	COG0840	transmembrane signaling receptor activity
EN18_03420	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EN18_03425	COG1126	abc transporter atp-binding protein
EN18_03435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EN18_03440	COG4597	amino acid ABC transporter
EN18_03445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EN18_03455	COG0739	heme binding
EN18_03465	COG2213	PTS system mannitol-specific
EN18_03465	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EN18_03470	COG0246	Mannitol dehydrogenase
EN18_03475	COG3722	fumarate hydratase activity
EN18_03480	COG0673	inositol 2-dehydrogenase activity
EN18_03510	COG2910	NAD(P)H-binding
EN18_03520	COG0840	transmembrane signaling receptor activity
EN18_03525	COG4221	oxidoreductase activity
EN18_03535	COG1901	pseudouridine methyltransferase
EN18_03540	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EN18_03550	COG0531	amino acid
EN18_03555	COG1982	Orn Lys Arg decarboxylase major
EN18_03580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EN18_03605	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EN18_03615	COG0259	pyridoxamine-phosphate oxidase activity
EN18_03645	COG0745	RESPONSE REGULATOR receiver
EN18_03665	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
EN18_03670	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EN18_03675	COG0840	transmembrane signaling receptor activity
EN18_03680	COG0835	chemotaxis
EN18_03685	COG0835	chemotaxis
EN18_03690	COG2198	Histidine kinase
EN18_03690	COG0643	Histidine kinase
EN18_03695	COG2198	Histidine kinase
EN18_03695	COG0643	Histidine kinase
EN18_03720	COG0601	transmembrane transport
EN18_03725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EN18_03735	COG2194	sulfuric ester hydrolase activity
EN18_03740	COG0642	Histidine kinase
EN18_03745	COG0745	RESPONSE REGULATOR receiver
EN18_03775	COG1444	tRNA N-acetyltransferase activity
EN18_03780	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EN18_03815	COG0217	transcriptional regulatory protein
EN18_03820	COG2084	Dehydrogenase
EN18_03835	COG2909	trisaccharide binding
EN18_03840	COG0058	SHG alpha-glucan phosphorylase activity
EN18_03845	COG1640	4-alpha-glucanotransferase
EN18_03850	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EN18_03860	COG3501	Rhs element vgr protein
EN18_03895	COG0471	metal ion transport
EN18_03900	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EN18_03945	COG0671	phosphoesterase, PA-phosphatase related
EN18_03950	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
EN18_03960	COG1999	signal sequence binding
EN18_03975	COG0786	glutamate:sodium symporter activity
EN18_03995	COG1566	PFAM secretion protein HlyD family protein
EN18_04005	COG3706	GGDEF domain
EN18_04020	COG0813	purine-nucleoside phosphorylase activity
EN18_04025	COG3272	Protein of unknown function (DUF1722)
EN18_04035	COG0415	Belongs to the DNA photolyase family
EN18_04040	COG1388	LysM domain
EN18_04040	COG1376	ErfK ybiS ycfS ynhG family protein
EN18_04050	COG0513	Belongs to the DEAD box helicase family
EN18_04055	COG1770	oligopeptidase
EN18_04085	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EN18_04090	COG0573	inorganic phosphate transmembrane transporter activity
EN18_04095	COG0581	inorganic phosphate transmembrane transporter activity
EN18_04100	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EN18_04120	COG0659	secondary active sulfate transmembrane transporter activity
EN18_04130	COG0739	heme binding
EN18_04135	COG3300	MHYT domain
EN18_04135	COG5001	Diguanylate cyclase
EN18_04140	COG0583	DNA-binding transcription factor activity
EN18_04145	COG2814	Major facilitator Superfamily
EN18_04170	COG1301	dicarboxylic acid transport
EN18_04180	COG1342	Belongs to the UPF0251 family
EN18_04215	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EN18_04220	COG0673	inositol 2-dehydrogenase activity
EN18_04230	COG2771	luxR family
EN18_04230	COG2200	EAL domain
EN18_04235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EN18_04245	COG0564	pseudouridine synthase activity
EN18_04335	COG3501	Rhs element vgr protein
EN18_04350	COG1869	D-ribose catabolic process
EN18_04355	COG1129	ABC transporter
EN18_04360	COG1172	Belongs to the binding-protein-dependent transport system permease family
EN18_04365	COG1879	ABC-type sugar transport system periplasmic component
EN18_04370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EN18_04375	COG1609	Transcriptional regulator
EN18_04385	COG3201	nicotinamide mononucleotide transporter
EN18_04390	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
EN18_04400	COG0584	glycerophosphoryl diester phosphodiesterase
EN18_04405	COG2271	Major facilitator Superfamily
EN18_04445	COG0579	oxidoreductase
EN18_04455	COG0242	peptide deformylase activity
EN18_04465	COG1320	monovalent cation:proton antiporter activity
EN18_04470	COG2212	antiporter activity
EN18_04490	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EN18_04490	COG2111	Na H antiporter
EN18_04500	COG0589	response to stress
EN18_04505	COG0814	amino acid
EN18_04510	COG3033	Beta-eliminating lyase
EN18_04515	COG3530	Putative quorum-sensing-regulated virulence factor
EN18_04530	COG5001	Diguanylate cyclase
EN18_04530	COG5002	protein histidine kinase activity
EN18_04535	COG1278	Cold shock
EN18_04550	COG2304	oxidoreductase activity
EN18_04570	COG0714	Associated with various cellular activities
EN18_04575	COG0840	transmembrane signaling receptor activity
EN18_04590	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EN18_04595	COG2195	Cleaves the N-terminal amino acid of tripeptides
EN18_04605	COG3604	Transcriptional regulator
EN18_04610	COG1017	nitric oxide dioxygenase activity
EN18_04610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EN18_04615	COG1278	Cold shock
EN18_04620	COG3036	rescue of stalled ribosome
EN18_04645	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EN18_04645	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EN18_04650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EN18_04660	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EN18_04670	COG0516	GMP reductase activity
EN18_04695	COG1943	Transposase
EN18_04700	COG0513	Belongs to the DEAD box helicase family
EN18_04705	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EN18_04710	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EN18_04715	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EN18_04720	COG3437	response regulator, receiver
EN18_04720	COG0784	Response regulator, receiver
EN18_04725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EN18_04725	COG4191	Histidine kinase
EN18_04735	COG1757	Na H antiporter
EN18_04740	COG2814	Major facilitator Superfamily
EN18_04750	COG3706	GGDEF domain
EN18_04755	COG3240	lipase activity
EN18_04765	COG0840	transmembrane signaling receptor activity
EN18_04770	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
EN18_04775	COG5380	lipid catabolic process
EN18_04780	COG4412	M6 family metalloprotease domain protein
EN18_04780	COG3291	Pkd domain containing protein
EN18_04800	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EN18_04805	COG4605	iron ion homeostasis
EN18_04810	COG4604	ABC transporter, ATP-binding protein
EN18_04830	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EN18_04850	COG0745	RESPONSE REGULATOR receiver
EN18_04865	COG3623	hexulose-6-phosphate isomerase
EN18_04870	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
EN18_04875	COG0561	phosphatase activity
EN18_04905	COG3038	cytochrome b561
EN18_04910	COG0366	Alpha amylase catalytic
EN18_04925	COG4974	Belongs to the 'phage' integrase family
EN18_05075	COG0616	signal peptide processing
EN18_05125	COG0776	regulation of translation
EN18_05185	COG3316	Transposase and inactivated derivatives
EN18_05205	COG3316	Transposase and inactivated derivatives
EN18_05285	COG1192	Involved in chromosome partitioning
EN18_05370	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EN18_05490	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EN18_05515	COG5001	Diguanylate cyclase
EN18_05550	COG0714	Associated with various cellular activities
EN18_05560	COG0629	single-stranded DNA binding
EN18_05605	COG0633	Ferredoxin
EN18_05760	COG3344	reverse transcriptase
EN18_05815	COG1695	Transcriptional regulator
EN18_05820	COG3316	Transposase and inactivated derivatives
EN18_05835	COG3173	Aminoglycoside phosphotransferase
EN18_05840	COG3316	Transposase and inactivated derivatives
EN18_05925	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EN18_05935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EN18_05940	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EN18_05945	COG1489	DNA binding
EN18_05955	COG1643	Atp-dependent helicase
EN18_05960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EN18_05965	COG1752	Esterase of the alpha-beta hydrolase superfamily
EN18_05970	COG1049	propionate catabolic process, 2-methylcitrate cycle
EN18_05975	COG3112	Uncharacterised protein family (UPF0231)
EN18_05980	COG0347	Belongs to the P(II) protein family
EN18_05985	COG0004	ammonium transporteR
EN18_05990	COG1840	ABC-type Fe3 transport system, periplasmic component
EN18_06000	COG3842	ATPase activity
EN18_06020	COG2971	BadF BadG BcrA BcrD
EN18_06030	COG4608	Belongs to the ABC transporter superfamily
EN18_06035	COG0444	Belongs to the ABC transporter superfamily
EN18_06040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EN18_06045	COG0601	transmembrane transport
EN18_06050	COG0747	negative chemotaxis
EN18_06060	COG2813	Specifically methylates the guanine in position
EN18_06065	COG0628	permease
EN18_06070	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EN18_06080	COG0316	Belongs to the HesB IscA family
EN18_06095	COG0739	heme binding
EN18_06100	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EN18_06105	COG2027	D-alanyl-D-alanine carboxypeptidase
EN18_06110	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EN18_06115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EN18_06120	COG1534	Rna-binding protein
EN18_06125	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EN18_06130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EN18_06135	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EN18_06140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EN18_06145	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EN18_06160	COG0779	Required for maturation of 30S ribosomal subunits
EN18_06165	COG0195	Participates in both transcription termination and antitermination
EN18_06170	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EN18_06175	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EN18_06180	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EN18_06185	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EN18_06190	COG1185	polyribonucleotide nucleotidyltransferase activity
EN18_06195	COG4785	May be involved in cell division
EN18_06230	COG3153	acetyltransferase
EN18_06395	COG3328	transposase activity
EN18_06485	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EN18_06500	COG0681	Belongs to the peptidase S26 family
EN18_06540	COG2356	endonuclease I
EN18_06555	COG0629	single-stranded DNA binding
EN18_06575	COG0714	Associated with various cellular activities
EN18_06600	COG2003	Belongs to the UPF0758 family
EN18_06710	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EN18_06715	COG0513	Belongs to the DEAD box helicase family
EN18_06720	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EN18_06730	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EN18_06735	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EN18_06740	COG2204	response regulator
EN18_06750	COG0667	Aldo Keto reductase
EN18_06755	COG3066	DNA modification
EN18_06765	COG0494	nUDIX hydrolase
EN18_06770	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
EN18_06775	COG0730	response to heat
EN18_06780	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EN18_06785	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EN18_06790	COG1283	sodium-dependent phosphate transmembrane transporter activity
EN18_06795	COG0583	DNA-binding transcription factor activity
EN18_06800	COG0640	Transcriptional regulator
EN18_06805	COG0268	Binds directly to 16S ribosomal RNA
EN18_06810	COG0728	peptidoglycan biosynthetic process
EN18_06815	COG0196	riboflavin kinase activity
EN18_06820	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EN18_06825	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EN18_06830	COG1047	Peptidyl-prolyl cis-trans
EN18_06835	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EN18_06840	COG1966	Carbon starvation protein
EN18_06855	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EN18_06860	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EN18_06865	COG1472	Belongs to the glycosyl hydrolase 3 family
EN18_06870	COG3279	Response regulator of the LytR AlgR family
EN18_06875	COG3275	phosphorelay sensor kinase activity
EN18_06880	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EN18_06885	COG0287	Prephenate dehydrogenase
EN18_06885	COG1605	Chorismate mutase
EN18_06895	COG0488	(ABC) transporter
EN18_06905	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
EN18_06910	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EN18_06915	COG5001	Diguanylate cyclase
EN18_06920	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EN18_06925	COG1605	Chorismate mutase
EN18_06925	COG0077	Prephenate dehydratase
EN18_06930	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EN18_06935	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EN18_06940	COG0564	pseudouridine synthase activity
EN18_06950	COG0542	response to heat
EN18_06990	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EN18_07000	COG2974	May be involved in recombination
EN18_07005	COG0745	RESPONSE REGULATOR receiver
EN18_07010	COG5002	protein histidine kinase activity
EN18_07020	COG0248	Ppx GppA phosphatase
EN18_07025	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EN18_07035	COG0581	inorganic phosphate transmembrane transporter activity
EN18_07040	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EN18_07055	COG3142	Participates in the control of copper homeostasis
EN18_07060	COG0450	alkyl hydroperoxide reductase
EN18_07065	COG0583	DNA-binding transcription factor activity
EN18_07070	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EN18_07080	COG0517	IMP dehydrogenase activity
EN18_07085	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EN18_07090	COG0343	queuine tRNA-ribosyltransferase activity
EN18_07095	COG1862	Preprotein translocase
EN18_07100	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EN18_07105	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EN18_07110	COG0483	inositol monophosphate 1-phosphatase activity
EN18_07120	COG1959	2 iron, 2 sulfur cluster binding
EN18_07125	COG1104	cysteine desulfurase activity
EN18_07130	COG0822	iron-sulfur transferase activity
EN18_07140	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EN18_07145	COG0443	Heat shock 70 kDa protein
EN18_07150	COG0633	Ferredoxin
EN18_07155	COG2975	iron-sulfur cluster assembly
EN18_07160	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EN18_07165	COG0105	UTP biosynthetic process
EN18_07170	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EN18_07180	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EN18_07185	COG0124	histidyl-tRNA synthetase
EN18_07190	COG2976	Protein conserved in bacteria
EN18_07195	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EN18_07200	COG1160	GTP binding
EN18_07215	COG1570	exodeoxyribonuclease VII activity
EN18_07220	COG0516	GMP reductase activity
EN18_07220	COG0517	IMP dehydrogenase activity
EN18_07225	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EN18_07225	COG0519	Catalyzes the synthesis of GMP from XMP
EN18_07240	COG1584	GPR1 FUN34 yaaH family protein
EN18_07245	COG1535	isochorismatase
EN18_07245	COG3433	isochorismatase activity
EN18_07250	COG1021	2,3-dihydroxybenzoate-AMP ligase
EN18_07255	COG1169	isochorismate synthase
EN18_07260	COG1028	Short-chain dehydrogenase reductase Sdr
EN18_07270	COG4592	Periplasmic binding protein
EN18_07275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EN18_07280	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EN18_07285	COG1120	ATPase activity
EN18_07295	COG0583	DNA-binding transcription factor activity
EN18_07300	COG2015	COG2015, Alkyl sulfatase and related hydrolases
EN18_07305	COG1115	amino acid carrier protein
EN18_07310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EN18_07315	COG0583	DNA-binding transcription factor activity
EN18_07330	COG4565	transcriptional regulatory protein
EN18_07340	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EN18_07345	COG0511	ligase activity, forming carbon-carbon bonds
EN18_07345	COG5016	pyruvate
EN18_07350	COG3630	sodium ion export across plasma membrane
EN18_07360	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
EN18_07365	COG3052	prosthetic group binding
EN18_07370	COG2301	Belongs to the HpcH HpaI aldolase family
EN18_07375	COG3051	citrate lyase alpha subunit
EN18_07380	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
EN18_07385	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
EN18_07395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EN18_07400	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EN18_07405	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
EN18_07465	COG1012	belongs to the aldehyde dehydrogenase family
EN18_07485	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EN18_07490	COG0840	transmembrane signaling receptor activity
EN18_07495	COG3710	Transcriptional regulator
EN18_07505	COG2165	general secretion pathway protein
EN18_07520	COG4796	Type ii and iii secretion system protein
EN18_07540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EN18_07545	COG1459	type II secretion system
EN18_07555	COG2207	Transcriptional regulator
EN18_07560	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EN18_07585	COG0739	heme binding
EN18_07595	COG3064	Membrane
EN18_07605	COG0582	viral genome integration into host DNA
EN18_07610	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EN18_07615	COG2867	negative regulation of translational initiation
EN18_07620	COG2914	Belongs to the UPF0125 (RnfH) family
EN18_07625	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EN18_07630	COG0497	DNA recombination
EN18_07635	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EN18_07640	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EN18_07645	COG0443	Heat shock 70 kDa protein
EN18_07650	COG0484	heat shock protein binding
EN18_07680	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EN18_07685	COG0590	tRNA wobble adenosine to inosine editing
EN18_07695	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EN18_07705	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EN18_07705	COG0047	phosphoribosylformylglycinamidine synthase activity
EN18_07710	COG1943	Transposase
EN18_07730	COG0442	prolyl-tRNA aminoacylation
EN18_07735	COG1720	tRNA m6t6A37 methyltransferase activity
EN18_07740	COG0254	rRNA binding
EN18_07745	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EN18_07750	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EN18_07755	COG1671	Belongs to the UPF0178 family
EN18_07765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EN18_07780	COG3098	single-species biofilm formation
EN18_07785	COG0564	pseudouridine synthase activity
EN18_07790	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EN18_07795	COG0142	geranyltranstransferase activity
EN18_07800	COG1722	exodeoxyribonuclease VII activity
EN18_07805	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EN18_07815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EN18_07815	COG0301	tRNA thio-modification
EN18_07825	COG0583	DNA-binding transcription factor activity
EN18_07830	COG2363	Small membrane protein
EN18_07835	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EN18_07840	COG1611	Belongs to the LOG family
EN18_07845	COG3706	GGDEF domain
EN18_07855	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EN18_07855	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EN18_07865	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
EN18_07870	COG1464	Belongs to the NlpA lipoprotein family
EN18_07875	COG2011	ABC-type metal ion transport system permease component
EN18_07880	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EN18_07885	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EN18_07890	COG1609	Transcriptional regulator
EN18_07895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EN18_07895	COG1263	PTS System
EN18_07900	COG0366	Alpha amylase catalytic
EN18_07930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EN18_07935	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EN18_07940	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EN18_07945	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EN18_07950	COG0110	maltose O-acetyltransferase activity
EN18_07970	COG1045	serine acetyltransferase
EN18_07980	COG0438	transferase activity, transferring glycosyl groups
EN18_07990	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
EN18_08020	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EN18_08030	COG1596	polysaccharide export
EN18_08055	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EN18_08065	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EN18_08070	COG0321	lipoyl(octanoyl) transferase activity
EN18_08075	COG2921	Belongs to the UPF0250 family
EN18_08080	COG1686	Belongs to the peptidase S11 family
EN18_08085	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EN18_08090	COG0772	Belongs to the SEDS family
EN18_08095	COG0768	penicillin binding
EN18_08100	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EN18_08105	COG0799	negative regulation of ribosome biogenesis
EN18_08110	COG1466	dna polymerase III delta subunit
EN18_08115	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
EN18_08120	COG0495	leucyl-tRNA aminoacylation
EN18_08125	COG2888	peptidyl-tyrosine sulfation
EN18_08130	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EN18_08135	COG4535	Mg2 and Co2 transporter CorC
EN18_08140	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EN18_08145	COG1702	phosphate starvation-inducible protein PhoH
EN18_08150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EN18_08155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EN18_08160	COG2190	(PTS) system
EN18_08170	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EN18_08175	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EN18_08180	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
EN18_08185	COG3115	cell septum assembly
EN18_08190	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EN18_08205	COG0789	Transcriptional regulator
EN18_08210	COG1585	Membrane protein implicated in regulation of membrane protease activity
EN18_08215	COG0330	HflC and HflK could
EN18_08220	COG3118	belongs to the thioredoxin family
EN18_08230	COG0300	oxidoreductase activity
EN18_08235	COG1090	epimerase
EN18_08240	COG0622	Phosphoesterase
EN18_08255	COG3710	Transcriptional regulator
EN18_08260	COG0326	Molecular chaperone. Has ATPase activity
EN18_08265	COG0563	adenylate kinase activity
EN18_08270	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EN18_08285	COG0367	asparagine synthase
EN18_08290	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EN18_08290	COG4651	solute:proton antiporter activity
EN18_08295	COG1940	carbohydrate kinase activity
EN18_08295	COG1846	Transcriptional regulator
EN18_08300	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EN18_08305	COG1263	PTS System
EN18_08305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EN18_08305	COG2190	(PTS) system
EN18_08310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EN18_08320	COG0101	tRNA pseudouridine synthase activity
EN18_08325	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EN18_08330	COG0285	dihydrofolate synthase activity
EN18_08335	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
EN18_08340	COG1286	toxin biosynthetic process
EN18_08345	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EN18_08350	COG2056	Na+-H+ antiporter family
EN18_08355	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EN18_08375	COG0346	lactoylglutathione lyase activity
EN18_08380	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EN18_08385	COG4660	Part of a membrane complex involved in electron transport
EN18_08390	COG4659	FMN binding
EN18_08395	COG4658	electron transport chain
EN18_08400	COG4656	Part of a membrane complex involved in electron transport
EN18_08405	COG2878	Part of a membrane complex involved in electron transport
EN18_08410	COG4657	Part of a membrane complex involved in electron transport
EN18_08425	COG0556	nucleotide-excision repair
EN18_08435	COG2204	response regulator
EN18_08440	COG2198	Histidine kinase
EN18_08445	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EN18_08450	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EN18_08455	COG0521	Mo-molybdopterin cofactor biosynthetic process
EN18_08460	COG0315	cyclic pyranopterin monophosphate synthase activity
EN18_08465	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EN18_08470	COG0314	molybdopterin synthase activity
EN18_08475	COG2199	diguanylate cyclase activity
EN18_08480	COG4109	DRTGG domain
EN18_08490	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
EN18_08500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EN18_08500	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EN18_08505	COG0489	protein tyrosine kinase activity
EN18_08515	COG0572	uridine kinase
EN18_08520	COG2982	Protein involved in outer membrane biogenesis
EN18_08525	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
EN18_08530	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EN18_08540	COG2067	long-chain fatty acid transport protein
EN18_08565	COG0183	Belongs to the thiolase family
EN18_08570	COG1250	3-hydroxyacyl-CoA dehydrogenase
EN18_08570	COG1024	Enoyl-CoA hydratase
EN18_08575	COG0778	Nitroreductase
EN18_08580	COG0583	DNA-binding transcription factor activity
EN18_08585	COG0745	RESPONSE REGULATOR receiver
EN18_08595	COG2832	Protein of unknown function (DUF454)
EN18_08600	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EN18_08610	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EN18_08615	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EN18_08630	COG1028	Short-chain dehydrogenase reductase Sdr
EN18_08635	COG0616	signal peptide processing
EN18_08645	COG1522	sequence-specific DNA binding
EN18_08650	COG1946	Acyl-CoA thioesterase
EN18_08670	COG3706	GGDEF domain
EN18_08675	COG0640	Transcriptional regulator
EN18_08680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EN18_08705	COG1881	PFAM PEBP family protein
EN18_08725	COG0009	L-threonylcarbamoyladenylate synthase
EN18_08740	COG2201	protein-glutamate methylesterase activity
EN18_08750	COG5002	protein histidine kinase activity
EN18_08755	COG4191	Histidine kinase
EN18_08760	COG5001	Diguanylate cyclase
EN18_08760	COG3300	MHYT domain
EN18_08765	COG2204	response regulator
EN18_08785	COG0601	transmembrane transport
EN18_08790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EN18_08795	COG0444	Belongs to the ABC transporter superfamily
EN18_08800	COG4608	Belongs to the ABC transporter superfamily
EN18_08805	COG0435	Glutathione S-transferase
EN18_08810	COG0280	phosphate acetyltransferase
EN18_08810	COG0857	belongs to the CobB CobQ family
EN18_08815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EN18_08820	COG3092	negative regulation of chromosome organization
EN18_08825	COG4628	conserved protein (DUF2132)
EN18_08835	COG4120	Belongs to the binding-protein-dependent transport system permease family
EN18_08845	COG2199	diguanylate cyclase activity
EN18_08845	COG2203	Gaf domain
EN18_08850	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EN18_08860	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EN18_08865	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EN18_08870	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EN18_08875	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EN18_08880	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EN18_08885	COG0156	8-amino-7-oxononanoate synthase activity
EN18_08890	COG2226	methyltransferase
EN18_08895	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EN18_08905	COG0501	Belongs to the peptidase M48B family
EN18_08915	COG0300	oxidoreductase activity
EN18_08930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EN18_08940	COG2268	Band 7 protein
EN18_08950	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EN18_08955	COG2915	High frequency lysogenization protein hflD homolog
EN18_08960	COG0482	sulfurtransferase activity
EN18_08965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EN18_08970	COG2916	Histone family protein nucleoid-structuring protein H-NS
EN18_08975	COG1757	Na H antiporter
EN18_08980	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EN18_08985	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EN18_08990	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EN18_08995	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EN18_08995	COG0131	Imidazoleglycerol-phosphate dehydratase
EN18_09000	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EN18_09005	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EN18_09010	COG0107	imidazoleglycerol-phosphate synthase activity
EN18_09015	COG0140	phosphoribosyl-ATP diphosphatase activity
EN18_09015	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EN18_09020	COG1187	pseudouridine synthase activity
EN18_09030	COG1278	Cold shock
EN18_09035	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EN18_09040	COG0542	response to heat
EN18_09050	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EN18_09055	COG1454	alcohol dehydrogenase
EN18_09055	COG1012	belongs to the aldehyde dehydrogenase family
EN18_09060	COG1737	Transcriptional regulator
EN18_09065	COG0076	glutamate decarboxylase activity
EN18_09075	COG2431	L-lysine efflux transmembrane transporter activity
EN18_09085	COG3070	regulator of competence-specific genes
EN18_09100	COG3852	Histidine kinase
EN18_09110	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EN18_09125	COG0189	ligase activity
EN18_09125	COG4067	protein conserved in archaea
EN18_09130	COG0500	methyltransferase
EN18_09135	COG4106	trans-aconitate 2-methyltransferase activity
EN18_09140	COG1801	Protein of unknown function DUF72
EN18_09145	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EN18_09150	COG1435	thymidine kinase activity
EN18_09160	COG0159	tryptophan synthase activity
EN18_09165	COG0133	tryptophan synthase activity
EN18_09170	COG0134	indole-3-glycerol-phosphate synthase activity
EN18_09170	COG0135	phosphoribosylanthranilate isomerase activity
EN18_09175	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EN18_09180	COG0512	Glutamine amidotransferase of anthranilate synthase
EN18_09185	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EN18_09195	COG0613	PHP domain protein
EN18_09200	COG0009	L-threonylcarbamoyladenylate synthase
EN18_09205	COG1187	pseudouridine synthase activity
EN18_09210	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EN18_09215	COG4988	ABC transporter
EN18_09220	COG0492	ferredoxin-NADP+ reductase activity
EN18_09230	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EN18_09235	COG3706	GGDEF domain
EN18_09240	COG2949	membrane
EN18_09250	COG0281	malic enzyme
EN18_09260	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EN18_09280	COG2885	chlorophyll binding
EN18_09295	COG0277	FAD linked oxidase domain protein
EN18_09295	COG0247	lactate metabolic process
EN18_09315	COG2986	histidine ammonia-lyase
EN18_09320	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EN18_09325	COG0010	Belongs to the arginase family
EN18_09330	COG1228	amidohydrolase
EN18_09350	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EN18_09360	COG5001	Diguanylate cyclase
EN18_09365	COG0417	DNA replication proofreading
EN18_09370	COG2197	response regulator
EN18_09375	COG0322	excinuclease ABC activity
EN18_09405	COG0745	RESPONSE REGULATOR receiver
EN18_09405	COG3706	GGDEF domain
EN18_09415	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EN18_09420	COG0072	phenylalanine-tRNA ligase activity
EN18_09420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EN18_09425	COG0776	regulation of translation
EN18_09440	COG0500	methyltransferase
EN18_09455	COG0295	cytidine deaminase activity
EN18_09460	COG1346	cytolysis
EN18_09470	COG2925	Exonuclease
EN18_09480	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EN18_09490	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EN18_09495	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EN18_09510	COG2988	succinylglutamate desuccinylase activity
EN18_09515	COG4139	cobalamin transport
EN18_09520	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
EN18_09565	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EN18_09570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EN18_09575	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EN18_09595	COG2814	Major facilitator Superfamily
EN18_09605	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EN18_09630	COG2989	Protein conserved in bacteria
EN18_09635	COG3108	Peptidase M15
EN18_09640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EN18_09655	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EN18_09680	COG1846	Transcriptional regulator
EN18_09685	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EN18_09690	COG0726	polysaccharide deacetylase
EN18_09695	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EN18_09705	COG1447	Phosphotransferase system cellobiose-specific component IIA
EN18_09710	COG1486	melibiose metabolic process
EN18_09715	COG3394	polysaccharide catabolic process
EN18_09720	COG1609	Transcriptional regulator
EN18_09725	COG2943	transferase activity, transferring hexosyl groups
EN18_09730	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
EN18_09735	COG0840	transmembrane signaling receptor activity
EN18_09750	COG1448	Aminotransferase
EN18_09760	COG3437	response regulator, receiver
EN18_09760	COG2770	Histidine kinase
EN18_09765	COG0351	phosphomethylpyrimidine kinase
EN18_09770	COG0017	Asparaginyl-tRNA synthetase
EN18_09780	COG0720	synthase
EN18_09785	COG1760	l-serine dehydratase
EN18_09790	COG0814	amino acid
EN18_09795	COG0494	nUDIX hydrolase
EN18_09800	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EN18_09815	COG3106	COG3106 Predicted ATPase
EN18_09820	COG3768	UPF0283 membrane protein
EN18_09825	COG3283	Transcriptional regulator of aromatic amino acids metabolism
EN18_09830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EN18_09845	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EN18_09855	COG0471	metal ion transport
EN18_09860	COG4191	Histidine kinase
EN18_09860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EN18_09870	COG2990	Protein conserved in bacteria
EN18_09875	COG3713	MltA-interacting MipA family protein
EN18_09880	COG2205	protein histidine kinase activity
EN18_09885	COG0745	RESPONSE REGULATOR receiver
EN18_09910	COG1129	ABC transporter
EN18_09945	COG2186	Transcriptional regulator
EN18_09950	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EN18_09955	COG0372	Belongs to the citrate synthase family
EN18_09985	COG2195	Cleaves the N-terminal amino acid of tripeptides
EN18_10000	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EN18_10010	COG0625	glutathione transferase activity
EN18_10015	COG3437	response regulator, receiver
EN18_10030	COG3706	GGDEF domain
EN18_10035	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EN18_10040	COG1254	Belongs to the acylphosphatase family
EN18_10045	COG2920	part of a sulfur-relay system
EN18_10050	COG0670	Belongs to the BI1 family
EN18_10055	COG1126	abc transporter atp-binding protein
EN18_10060	COG0765	amino acid transport
EN18_10065	COG4597	amino acid ABC transporter
EN18_10070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EN18_10080	COG0561	phosphatase activity
EN18_10085	COG0602	queuosine metabolic process
EN18_10090	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EN18_10120	COG3706	GGDEF domain
EN18_10125	COG0443	Heat shock 70 kDa protein
EN18_10130	COG0443	Heat shock 70 kDa protein
EN18_10160	COG1643	Atp-dependent helicase
EN18_10170	COG0443	Heat shock 70 kDa protein
EN18_10175	COG0095	Lipoate-protein ligase
EN18_10180	COG0583	DNA-binding transcription factor activity
EN18_10185	COG0477	Major facilitator Superfamily
EN18_10190	COG0415	Belongs to the DNA photolyase family
EN18_10195	COG2076	Multidrug Resistance protein
EN18_10215	COG0643	Histidine kinase
EN18_10215	COG2198	Histidine kinase
EN18_10225	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EN18_10235	COG2201	protein-glutamate methylesterase activity
EN18_10240	COG0835	chemotaxis
EN18_10245	COG0840	transmembrane signaling receptor activity
EN18_10245	COG3290	protein histidine kinase activity
EN18_10250	COG0840	transmembrane signaling receptor activity
EN18_10260	COG0513	Belongs to the DEAD box helicase family
EN18_10270	COG1538	Outer membrane efflux protein
EN18_10275	COG1566	PFAM secretion protein HlyD family protein
EN18_10280	COG2814	Major facilitator Superfamily
EN18_10285	COG0840	transmembrane signaling receptor activity
EN18_10290	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EN18_10300	COG3501	Rhs element vgr protein
EN18_10325	COG1280	lysine exporter protein (LysE YggA)
EN18_10330	COG1115	amino acid carrier protein
EN18_10345	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EN18_10350	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EN18_10355	COG1177	transmembrane transport
EN18_10360	COG1176	ABC-type spermidine putrescine transport system, permease component I
EN18_10365	COG3842	ATPase activity
EN18_10385	COG0037	tRNA processing
EN18_10390	COG0589	response to stress
EN18_10395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EN18_10410	COG2217	Heavy metal translocating P-type atpase
EN18_10420	COG2010	Cytochrome c
EN18_10435	COG3278	Belongs to the heme-copper respiratory oxidase family
EN18_10450	COG0784	Response regulator, receiver
EN18_10450	COG2205	protein histidine kinase activity
EN18_10475	COG2994	toxin metabolic process
EN18_10480	COG3064	Membrane
EN18_10480	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
EN18_10480	COG1073	alpha beta
EN18_10495	COG4128	Pfam Zonular occludens toxin
EN18_10530	COG1476	TRANSCRIPTIONal
EN18_10550	COG1476	TRANSCRIPTIONal
EN18_10600	COG3328	transposase activity
EN18_10615	COG3120	sequence-specific DNA binding
EN18_10620	COG1067	ATP-dependent peptidase activity
EN18_10625	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EN18_10645	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EN18_10645	COG0116	Belongs to the methyltransferase superfamily
EN18_10655	COG0167	dihydroorotate dehydrogenase activity
EN18_10670	COG0308	aminopeptidase N
EN18_10685	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
EN18_10690	COG1956	GAF domain-containing protein
EN18_10695	COG1132	(ABC) transporter
EN18_10700	COG2995	paraquat-inducible protein a
EN18_10705	COG3008	intermembrane lipid transfer
EN18_10710	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
EN18_10710	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EN18_10715	COG2996	Protein conserved in bacteria
EN18_10730	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EN18_10740	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EN18_10755	COG0437	4 iron, 4 sulfur cluster binding
EN18_10760	COG3383	formate dehydrogenase (NAD+) activity
EN18_10760	COG0243	molybdopterin cofactor binding
EN18_10790	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EN18_10795	COG0488	(ABC) transporter
EN18_10800	COG3852	Histidine kinase
EN18_10805	COG2204	response regulator
EN18_10815	COG4662	Binding-protein-dependent transport system inner membrane component
EN18_10820	COG3842	ATPase activity
EN18_10825	COG0746	molybdenum cofactor guanylyltransferase activity
EN18_10855	COG1940	carbohydrate kinase activity
EN18_10870	COG0840	transmembrane signaling receptor activity
EN18_10875	COG0791	NLP P60 protein
EN18_10895	COG0534	Mate efflux family protein
EN18_10905	COG1793	dna ligase
EN18_10915	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EN18_10920	COG0848	biopolymer transport protein
EN18_10925	COG0811	peptide transport
EN18_10930	COG0811	peptide transport
EN18_10945	COG1175	transmembrane transport
EN18_10950	COG0395	ABC-type sugar transport system, permease component
EN18_10955	COG3842	ATPase activity
EN18_10960	COG1349	DNA-binding transcription factor activity
EN18_10965	COG0584	glycerophosphoryl diester phosphodiesterase
EN18_10970	COG2731	YhcH YjgK YiaL family protein
EN18_10975	COG0251	oxidation-reduction process
EN18_10980	COG1609	Transcriptional regulator
EN18_10985	COG2723	6-phospho-beta-galactosidase activity
EN18_10990	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EN18_10995	COG0583	DNA-binding transcription factor activity
EN18_11015	COG1136	(ABC) transporter
EN18_11015	COG0577	efflux transmembrane transporter activity
EN18_11020	COG1136	(ABC) transporter
EN18_11020	COG0577	efflux transmembrane transporter activity
EN18_11025	COG4591	ABC-type transport system involved in lipoprotein release permease component
EN18_11025	COG1136	(ABC) transporter
EN18_11030	COG1294	oxidase, subunit
EN18_11035	COG1271	oxidase subunit
EN18_11075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EN18_11085	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EN18_11105	COG0753	catalase activity
EN18_11135	COG2199	diguanylate cyclase activity
EN18_11135	COG2200	EAL domain
EN18_11140	COG3706	GGDEF domain
EN18_11145	COG2017	converts alpha-aldose to the beta-anomer
EN18_11150	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EN18_11155	COG1085	galactose-1-phosphate uridylyltransferase
EN18_11185	COG3706	GGDEF domain
EN18_11185	COG0745	RESPONSE REGULATOR receiver
EN18_11200	COG0835	chemotaxis
EN18_11200	COG0784	Response regulator, receiver
EN18_11210	COG4565	transcriptional regulatory protein
EN18_11215	COG3290	protein histidine kinase activity
EN18_11230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EN18_11250	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EN18_11255	COG3063	Type IV pilus biogenesis stability protein PilW
EN18_11265	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EN18_11270	COG1451	nucleotide metabolic process
EN18_11280	COG0583	DNA-binding transcription factor activity
EN18_11300	COG1538	Outer membrane efflux protein
EN18_11310	COG0019	diaminopimelate decarboxylase activity
EN18_11315	COG1748	Saccharopine dehydrogenase
EN18_11325	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EN18_11340	COG4181	ATPase activity
EN18_11345	COG0534	Mate efflux family protein
EN18_11350	COG0702	epimerase
EN18_11360	COG2814	Major facilitator Superfamily
EN18_11365	COG1187	pseudouridine synthase activity
EN18_11370	COG1061	Type III restriction enzyme res subunit
EN18_11390	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EN18_11395	COG3706	GGDEF domain
EN18_11395	COG4251	negative regulation of phosphorylation
EN18_11395	COG2203	Gaf domain
EN18_11395	COG5001	Diguanylate cyclase
EN18_11410	COG0840	transmembrane signaling receptor activity
EN18_11440	COG4934	collagen metabolic process
EN18_11460	COG2239	Acts as a magnesium transporter
EN18_11475	COG0814	amino acid
EN18_11480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EN18_11485	COG1131	(ABC) transporter
EN18_11490	COG0842	Transport permease protein
EN18_11500	COG3313	Fe-S protein
EN18_11510	COG4134	Bacterial extracellular solute-binding protein
EN18_11515	COG4135	transport system, permease component
EN18_11520	COG4136	ATPase activity
EN18_11525	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EN18_11530	COG0564	pseudouridine synthase activity
EN18_11535	COG0733	neurotransmitter:sodium symporter activity
EN18_11545	COG0626	cystathionine gamma-synthase activity
EN18_11550	COG2818	Glycosylase
EN18_11565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EN18_11580	COG1842	Phage shock protein A
EN18_11585	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EN18_11595	COG4168	peptide transport system, permease
EN18_11600	COG4171	peptide transport system, permease
EN18_11610	COG4172	Belongs to the ABC transporter superfamily
EN18_11625	COG1227	inorganic diphosphatase activity
EN18_11645	COG0243	molybdopterin cofactor binding
EN18_11650	COG3005	denitrification pathway
EN18_11655	COG4459	periplasmic nitrate reductase
EN18_11665	COG2116	formate transmembrane transporter activity
EN18_11675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EN18_11680	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EN18_11690	COG2917	probably involved in intracellular septation
EN18_11695	COG1607	acyl-coa hydrolase
EN18_11700	COG2350	Protein conserved in bacteria
EN18_11710	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EN18_11730	COG0612	Peptidase, M16
EN18_11740	COG1032	radical SAM domain protein
EN18_11755	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EN18_11760	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
EN18_11765	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
EN18_11770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EN18_11775	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EN18_11780	COG0745	RESPONSE REGULATOR receiver
EN18_11785	COG3381	protein complex oligomerization
EN18_11790	COG1609	Transcriptional regulator
EN18_11795	COG3070	regulator of competence-specific genes
EN18_11815	COG0297	glycogen (starch) synthase activity
EN18_11820	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EN18_11825	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EN18_11835	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EN18_11845	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EN18_11850	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EN18_11855	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EN18_11860	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EN18_11885	COG1012	belongs to the aldehyde dehydrogenase family
EN18_11890	COG1309	transcriptional regulator
EN18_11910	COG0668	transmembrane transport
EN18_11915	COG2995	paraquat-inducible protein a
EN18_11920	COG3008	intermembrane lipid transfer
EN18_11920	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EN18_11930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EN18_11945	COG0582	viral genome integration into host DNA
EN18_11955	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EN18_11975	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EN18_11995	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EN18_12015	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
EN18_12020	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
EN18_12025	COG1737	Transcriptional regulator
EN18_12030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EN18_12035	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EN18_12040	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EN18_12045	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EN18_12050	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
EN18_12055	COG1940	carbohydrate kinase activity
EN18_12060	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EN18_12065	COG4409	exo-alpha-(2->6)-sialidase activity
EN18_12075	COG2003	Belongs to the UPF0758 family
EN18_12095	COG3941	tape measure
EN18_12135	COG0488	(ABC) transporter
EN18_12215	COG0415	Belongs to the DNA photolyase family
EN18_12225	COG4628	conserved protein (DUF2132)
EN18_12230	COG3284	Transcriptional regulator
EN18_12235	COG1012	belongs to the aldehyde dehydrogenase family
EN18_12245	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EN18_12250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EN18_12255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EN18_12265	COG2207	Transcriptional regulator
EN18_12270	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EN18_12270	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EN18_12270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EN18_12275	COG1482	cell wall glycoprotein biosynthetic process
EN18_12285	COG5002	protein histidine kinase activity
EN18_12285	COG0784	Response regulator, receiver
EN18_12295	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EN18_12305	COG2885	chlorophyll binding
EN18_12310	COG0823	Involved in the tonB-independent uptake of proteins
EN18_12325	COG0811	peptide transport
EN18_12330	COG0824	Thioesterase
EN18_12335	COG3790	cyd operon protein YbgE
EN18_12340	COG4890	Cyd operon protein YbgT
EN18_12345	COG1294	oxidase, subunit
EN18_12350	COG1271	oxidase subunit
EN18_12355	COG2255	four-way junction helicase activity
EN18_12360	COG0632	four-way junction helicase activity
EN18_12365	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EN18_12370	COG0215	cysteine-tRNA ligase activity
EN18_12375	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EN18_12380	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EN18_12385	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EN18_12395	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EN18_12400	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EN18_12405	COG1199	ATP-dependent helicase activity
EN18_12410	COG0730	response to heat
EN18_12415	COG3923	Primosomal replication protein n
EN18_12425	COG0840	transmembrane signaling receptor activity
EN18_12430	COG0708	Exodeoxyribonuclease III
EN18_12435	COG4160	amino acid transport
EN18_12440	COG4215	(ABC) transporter
EN18_12460	COG1882	Formate acetyltransferase
EN18_12470	COG0840	transmembrane signaling receptor activity
EN18_12475	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EN18_12485	COG3013	Belongs to the UPF0304 family
EN18_12490	COG2766	serine protein kinase
EN18_12495	COG2718	Belongs to the UPF0229 family
EN18_12500	COG2719	SpoVR family
EN18_12505	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EN18_12515	COG1663	tetraacyldisaccharide 4'-kinase activity
EN18_12520	COG1132	(ABC) transporter
EN18_12525	COG0658	competence protein
EN18_12525	COG2333	competence protein COMEC
EN18_12535	COG4591	ABC-type transport system involved in lipoprotein release permease component
EN18_12540	COG1136	(ABC) transporter
EN18_12545	COG4591	ABC-type transport system involved in lipoprotein release permease component
EN18_12555	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EN18_12575	COG1252	NADH dehydrogenase
EN18_12605	COG0537	adenosine 5'-monophosphoramidase activity
EN18_12620	COG2186	Transcriptional regulator
EN18_12625	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EN18_12630	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EN18_12635	COG1674	ftsk spoiiie
EN18_12645	COG0686	Belongs to the AlaDH PNT family
EN18_12655	COG0583	DNA-binding transcription factor activity
EN18_12675	COG0284	orotidine-5'-phosphate decarboxylase activity
EN18_12680	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EN18_12685	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
EN18_12690	COG0776	regulation of translation
EN18_12695	COG0539	negative regulation of cytoplasmic translation
EN18_12700	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EN18_12705	COG1555	photosystem II stabilization
EN18_12710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EN18_12715	COG0776	regulation of translation
EN18_12720	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EN18_12725	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EN18_12735	COG0544	peptidyl-prolyl cis-trans isomerase activity
EN18_12745	COG4191	Histidine kinase
EN18_12755	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EN18_12760	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EN18_12765	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EN18_12770	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EN18_12785	COG3300	MHYT domain
EN18_12785	COG5001	Diguanylate cyclase
EN18_12795	COG4589	Belongs to the CDS family
EN18_12830	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EN18_12840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EN18_12860	COG0243	molybdopterin cofactor binding
EN18_12865	COG3005	denitrification pathway
EN18_12870	COG3469	chitinase activity
EN18_12870	COG3325	Belongs to the glycosyl hydrolase 18 family
EN18_12875	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EN18_12890	COG2951	lytic endotransglycosylase activity
EN18_12895	COG3100	YcgL domain-containing protein
EN18_12900	COG0850	regulation of cytokinetic process
EN18_12905	COG2894	cell division
EN18_12910	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EN18_12915	COG3015	lipoprotein NlpE involved in copper resistance
EN18_12935	COG0477	Major facilitator Superfamily
EN18_12945	COG0840	transmembrane signaling receptor activity
EN18_12950	COG1396	sequence-specific DNA binding
EN18_12955	COG3135	benzoate transporter
EN18_12965	COG1441	menaquinone biosynthetic process
EN18_12975	COG0596	Alpha beta hydrolase
EN18_12980	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EN18_12985	COG1169	isochorismate synthase
EN18_12990	COG0436	Aminotransferase
EN18_12995	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EN18_13000	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EN18_13020	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EN18_13025	COG0318	PFAM AMP-dependent synthetase and ligase
EN18_13030	COG0596	Alpha beta hydrolase
EN18_13045	COG1214	PFAM Peptidase M22, glycoprotease
EN18_13050	COG1199	ATP-dependent helicase activity
EN18_13060	COG0788	formyltetrahydrofolate deformylase activity
EN18_13065	COG0446	pyridine nucleotide-disulphide oxidoreductase
EN18_13065	COG1902	pentaerythritol trinitrate reductase activity
EN18_13070	COG0616	signal peptide processing
EN18_13075	COG0252	asparaginase activity
EN18_13080	COG3139	Protein of unknown function (DUF1315)
EN18_13090	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EN18_13095	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EN18_13100	COG0676	glucose-6-phosphate 1-epimerase activity
EN18_13110	COG2226	methyltransferase
EN18_13125	COG0835	chemotaxis
EN18_13125	COG0784	Response regulator, receiver
EN18_13130	COG1940	carbohydrate kinase activity
EN18_13140	COG4667	esterase of the alpha-beta hydrolase superfamily
EN18_13155	COG0733	neurotransmitter:sodium symporter activity
EN18_13165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EN18_13165	COG1263	PTS System
EN18_13170	COG0084	hydrolase, TatD family'
EN18_13180	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EN18_13185	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EN18_13190	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EN18_13195	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EN18_13200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EN18_13205	COG1028	Short-chain dehydrogenase reductase Sdr
EN18_13210	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EN18_13215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EN18_13220	COG0416	fatty acid biosynthetic process
EN18_13225	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EN18_13230	COG1399	metal-binding, possibly nucleic acid-binding protein
EN18_13235	COG0424	maF-like protein
EN18_13240	COG0564	pseudouridine synthase activity
EN18_13250	COG1530	ribonuclease E activity
EN18_13255	COG0659	secondary active sulfate transmembrane transporter activity
EN18_13265	COG1454	alcohol dehydrogenase
EN18_13265	COG1012	belongs to the aldehyde dehydrogenase family
EN18_13270	COG2095	MarC family integral membrane protein
EN18_13275	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EN18_13280	COG1757	Na H antiporter
EN18_13290	COG3081	Nucleoid-associated protein
EN18_13300	COG3083	sulfuric ester hydrolase activity
EN18_13315	COG0123	including yeast histone deacetylase and acetoin utilization protein
EN18_13320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EN18_13325	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EN18_13345	COG2853	Lipoprotein
EN18_13355	COG4235	cytochrome complex assembly
EN18_13355	COG3088	subunit of a heme lyase
EN18_13360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EN18_13365	COG1138	Cytochrome C-type biogenesis protein
EN18_13370	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EN18_13380	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EN18_13385	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EN18_13390	COG4133	protoheme IX ABC transporter activity
EN18_13400	COG0835	chemotaxis
EN18_13410	COG1192	Involved in chromosome partitioning
EN18_13415	COG2201	protein-glutamate methylesterase activity
EN18_13420	COG0643	Histidine kinase
EN18_13420	COG2198	Histidine kinase
EN18_13425	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EN18_13440	COG0455	bacterial-type flagellum organization
EN18_13455	COG2062	phosphohistidine phosphatase, SixA
EN18_13460	COG1025	Belongs to the peptidase M16 family
EN18_13470	COG0018	arginyl-trna synthetase
EN18_13490	COG1918	ferrous iron import across plasma membrane
EN18_13495	COG4977	sequence-specific DNA binding
EN18_13500	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
EN18_13505	COG1121	(ABC) transporter
EN18_13510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EN18_13520	COG0045	succinate-CoA ligase (ADP-forming) activity
EN18_13525	COG0508	dehydrogenase complex catalyzes the overall conversion of
EN18_13530	COG0567	Dehydrogenase, E1 component
EN18_13540	COG1053	succinate dehydrogenase
EN18_13545	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EN18_13550	COG2009	succinate dehydrogenase
EN18_13555	COG0372	Belongs to the citrate synthase family
EN18_13560	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EN18_13570	COG0033	Phosphoglucomutase
EN18_13575	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
EN18_13580	COG0596	Alpha beta hydrolase
EN18_13595	COG1346	cytolysis
EN18_13605	COG0583	DNA-binding transcription factor activity
EN18_13615	COG0735	belongs to the Fur family
EN18_13620	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EN18_13625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EN18_13630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EN18_13635	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EN18_13635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EN18_13640	COG0431	NADPH-dependent FMN reductase
EN18_13650	COG3101	peptidyl-lysine hydroxylation
EN18_13655	COG2860	membrane
EN18_13660	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EN18_13665	COG2890	protein-(glutamine-N5) methyltransferase activity
EN18_13675	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EN18_13680	COG1684	flagellar biosynthetic protein fliR
EN18_13685	COG1987	bacterial-type flagellum assembly
EN18_13710	COG1580	Controls the rotational direction of flagella during chemotaxis
EN18_13730	COG1317	bacterial-type flagellum organization
EN18_13735	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EN18_13745	COG1677	Flagellar hook-basal body complex protein FliE
EN18_13750	COG2204	response regulator
EN18_13755	COG4191	Histidine kinase
EN18_13760	COG2204	response regulator
EN18_13765	COG1516	flagellar protein fliS
EN18_13775	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EN18_13780	COG1334	flagellar protein FlaG
EN18_13785	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EN18_13790	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EN18_13795	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EN18_13800	COG2837	iron assimilation
EN18_13820	COG1393	Belongs to the ArsC family
EN18_13825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EN18_13830	COG1876	peptidase activity
EN18_13840	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EN18_13845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EN18_13855	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EN18_13875	COG4783	chaperone-mediated protein folding
EN18_13880	COG1393	Belongs to the ArsC family
EN18_13900	COG2233	PERMEase
EN18_13905	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EN18_13910	COG0737	Belongs to the 5'-nucleotidase family
EN18_13915	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EN18_13920	COG2912	Transglutaminase-like superfamily
EN18_13925	COG3094	Invasion gene expression up-regulator, SirB
EN18_13930	COG2890	protein-(glutamine-N5) methyltransferase activity
EN18_13935	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EN18_13940	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EN18_13945	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EN18_13950	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EN18_13955	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EN18_13960	COG0193	aminoacyl-tRNA hydrolase activity
EN18_13965	COG0012	GTP binding
EN18_14050	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EN18_14055	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EN18_14070	COG3951	Flagellar rod assembly protein muramidase FlgJ
EN18_14070	COG1705	Flagellar rod assembly protein muramidase FlgJ
EN18_14075	COG1706	bacterial-type flagellum-dependent cell motility
EN18_14080	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EN18_14085	COG4786	Flagellar basal body rod
EN18_14090	COG4787	bacterial-type flagellum-dependent cell motility
EN18_14095	COG1749	Flagellar hook protein flgE
EN18_14100	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EN18_14105	COG1558	bacterial-type flagellum-dependent cell motility
EN18_14110	COG1815	bacterial-type flagellum-dependent cell motility
EN18_14115	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EN18_14120	COG0784	Response regulator, receiver
EN18_14120	COG0835	chemotaxis
EN18_14155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EN18_14155	COG3433	isochorismatase activity
EN18_14155	COG2226	methyltransferase
EN18_14160	COG2375	cellular response to nickel ion
EN18_14165	COG1629	transport
EN18_14165	COG4774	siderophore transport
EN18_14180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EN18_14185	COG2217	Heavy metal translocating P-type atpase
EN18_14185	COG2608	mercury ion transmembrane transporter activity
EN18_14200	COG3735	TraB family
EN18_14215	COG2840	Smr protein MutS2
EN18_14220	COG1187	pseudouridine synthase activity
EN18_14225	COG3706	GGDEF domain
EN18_14230	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EN18_14235	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EN18_14240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EN18_14245	COG0121	glutamine amidotransferase
EN18_14250	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EN18_14255	COG1960	acyl-CoA dehydrogenase activity
EN18_14265	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EN18_14270	COG0328	RNA-DNA hybrid ribonuclease activity
EN18_14275	COG2226	methyltransferase
EN18_14280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EN18_14285	COG1388	LysM domain
EN18_14285	COG0741	lytic transglycosylase activity
EN18_14295	COG0347	Belongs to the P(II) protein family
EN18_14300	COG3479	Phenolic acid decarboxylase
EN18_14310	COG0037	tRNA processing
EN18_14315	COG0825	malonyl-CoA metabolic process
EN18_14320	COG0587	DNA-directed DNA polymerase activity
EN18_14325	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EN18_14330	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EN18_14335	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EN18_14340	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EN18_14345	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EN18_14350	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
EN18_14360	COG0750	zinc metalloprotease
EN18_14365	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EN18_14370	COG0575	Belongs to the CDS family
EN18_14375	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EN18_14380	COG0233	cytoplasmic translational termination
EN18_14385	COG0528	UMP kinase activity
EN18_14390	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EN18_14395	COG0052	Belongs to the universal ribosomal protein uS2 family
EN18_14400	COG0024	Methionine aminopeptidase
EN18_14405	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EN18_14415	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EN18_14420	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EN18_14425	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EN18_14430	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EN18_14445	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EN18_14445	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EN18_14450	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EN18_14455	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EN18_14460	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EN18_14475	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EN18_14480	COG2252	PERMEase
EN18_14485	COG2195	Cleaves the N-terminal amino acid of tripeptides
EN18_14490	COG0189	ligase activity
EN18_14490	COG4067	protein conserved in archaea
EN18_14495	COG0189	ligase activity
EN18_14505	COG0733	neurotransmitter:sodium symporter activity
EN18_14510	COG3706	GGDEF domain
EN18_14515	COG3328	transposase activity
EN18_14535	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EN18_14545	COG1477	protein flavinylation
EN18_14550	COG2871	sodium ion transport
EN18_14555	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EN18_14560	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EN18_14565	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EN18_14570	COG1805	sodium ion transport
EN18_14575	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EN18_14580	COG0271	Belongs to the BolA IbaG family
EN18_14585	COG2813	Specifically methylates the guanine in position
EN18_14595	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EN18_14600	COG2211	Major facilitator Superfamily
EN18_14610	COG1595	DNA-templated transcription, initiation
EN18_14620	COG3248	Nucleoside-binding outer membrane protein
EN18_14625	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EN18_14630	COG0693	protein deglycase activity
EN18_14635	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EN18_14640	COG2166	iron-sulfur cluster assembly
EN18_14645	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EN18_14650	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EN18_14660	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EN18_14660	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EN18_14675	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EN18_14680	COG1074	ATP-dependent DNA helicase activity
EN18_14685	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EN18_14700	COG3141	response to X-ray
EN18_14705	COG2171	N-acyltransferase activity
EN18_14715	COG0456	acetyltransferase
EN18_14725	COG0569	domain protein
EN18_14725	COG0189	ligase activity
EN18_14740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EN18_14745	COG1609	Transcriptional regulator
EN18_14750	COG3250	beta-galactosidase activity
EN18_14765	COG1022	Amp-dependent synthetase and ligase
EN18_14770	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EN18_14775	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EN18_14785	COG0560	Phosphoserine phosphatase
EN18_14795	COG0813	purine-nucleoside phosphorylase activity
EN18_14800	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EN18_14805	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EN18_14810	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EN18_14815	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EN18_14820	COG0084	hydrolase, TatD family'
EN18_14830	COG1115	amino acid carrier protein
EN18_14845	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EN18_14850	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EN18_14855	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
EN18_14860	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EN18_14865	COG0083	homoserine kinase activity
EN18_14880	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EN18_14890	COG0745	RESPONSE REGULATOR receiver
EN18_14895	COG5002	protein histidine kinase activity
EN18_14895	COG0784	Response regulator, receiver
EN18_14895	COG2198	Histidine kinase
EN18_14900	COG4251	negative regulation of phosphorylation
EN18_14900	COG3706	GGDEF domain
EN18_14900	COG2203	Gaf domain
EN18_14900	COG5001	Diguanylate cyclase
EN18_14905	COG1242	4 iron, 4 sulfur cluster binding
EN18_14910	COG0067	glutamate synthase
EN18_14910	COG0070	glutamate synthase
EN18_14910	COG0069	glutamate synthase activity
EN18_14920	COG0070	glutamate synthase
EN18_14920	COG0069	glutamate synthase activity
EN18_14920	COG0067	glutamate synthase
EN18_14925	COG0493	'glutamate synthase
EN18_14935	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EN18_14945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EN18_14950	COG2860	membrane
EN18_14955	COG0583	DNA-binding transcription factor activity
EN18_14960	COG0730	response to heat
EN18_14970	COG4172	Belongs to the ABC transporter superfamily
EN18_14990	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EN18_14995	COG0505	Belongs to the CarA family
EN18_15005	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EN18_15010	COG0494	nUDIX hydrolase
EN18_15015	COG0653	protein targeting
EN18_15025	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EN18_15030	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EN18_15035	COG0849	cell division
EN18_15040	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EN18_15045	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EN18_15050	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EN18_15055	COG0772	Belongs to the SEDS family
EN18_15060	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EN18_15065	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EN18_15070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EN18_15075	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EN18_15080	COG0768	penicillin binding
EN18_15085	COG3116	cell division
EN18_15090	COG0275	rRNA processing
EN18_15095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EN18_15100	COG0508	dehydrogenase complex catalyzes the overall conversion of
EN18_15105	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EN18_15110	COG2186	Transcriptional regulator
EN18_15115	COG0737	Belongs to the 5'-nucleotidase family
EN18_15120	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EN18_15125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EN18_15130	COG4974	Belongs to the 'phage' integrase family
EN18_15135	COG0716	FMN binding
EN18_15155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EN18_15160	COG1459	type II secretion system
EN18_15170	COG0237	dephospho-CoA kinase activity
EN18_15175	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EN18_15185	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EN18_15190	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EN18_15195	COG0187	DNA topoisomerase II activity
EN18_15200	COG3150	esterase
EN18_15210	COG3151	Protein conserved in bacteria
EN18_15215	COG0494	nUDIX hydrolase
EN18_15220	COG1538	Outer membrane efflux protein
EN18_15230	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EN18_15235	COG0840	transmembrane signaling receptor activity
EN18_15245	COG3025	triphosphatase activity
EN18_15250	COG1392	Phosphate transport regulator
EN18_15255	COG0306	phosphate transporter
EN18_15260	COG4991	sh3 domain protein
EN18_15270	COG3409	Peptidoglycan-binding domain 1 protein
EN18_15270	COG3267	Type II secretory pathway component ExeA
EN18_15275	COG0617	tRNA 3'-terminal CCA addition
EN18_15280	COG0148	phosphopyruvate hydratase activity
EN18_15285	COG0504	CTP synthase activity
EN18_15290	COG3956	TIGRFAM MazG family protein
EN18_15295	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EN18_15300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EN18_15310	COG5001	Diguanylate cyclase
EN18_15325	COG0736	holo-[acyl-carrier-protein] synthase activity
EN18_15330	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EN18_15335	COG1381	Involved in DNA repair and RecF pathway recombination
EN18_15340	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EN18_15345	COG0571	ribonuclease III activity
EN18_15350	COG0681	Belongs to the peptidase S26 family
EN18_15355	COG0481	GTPase activity
EN18_15360	COG3086	response to oxidative stress
EN18_15365	COG3026	antisigma factor binding
EN18_15375	COG1595	DNA-templated transcription, initiation
EN18_15380	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EN18_15390	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EN18_15395	COG0354	folic acid binding
EN18_15405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EN18_15410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EN18_15420	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EN18_15425	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EN18_15430	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EN18_15435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EN18_15440	COG0440	acetolactate synthase activity
EN18_15445	COG0028	Belongs to the TPP enzyme family
EN18_15450	COG1022	Amp-dependent synthetase and ligase
EN18_15455	COG0583	DNA-binding transcription factor activity
EN18_15475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EN18_15480	COG0473	3-isopropylmalate dehydrogenase activity
EN18_15485	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EN18_15490	COG0066	3-isopropylmalate dehydratase activity
EN18_15535	COG3437	response regulator, receiver
EN18_15550	COG0795	lipopolysaccharide-transporting ATPase activity
EN18_15555	COG0795	lipopolysaccharide-transporting ATPase activity
EN18_15560	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EN18_15565	COG2927	DNA polymerase III (CHI subunit)
EN18_15570	COG0525	valine-tRNA ligase activity
EN18_15575	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EN18_15580	COG0564	pseudouridine synthase activity
EN18_15585	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EN18_15595	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EN18_15600	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EN18_15610	COG0540	Belongs to the ATCase OTCase family
EN18_15615	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
EN18_15620	COG0251	oxidation-reduction process
EN18_15625	COG0204	Acyl-transferase
EN18_15630	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EN18_15635	COG5007	Belongs to the BolA IbaG family
EN18_15645	COG2854	intermembrane phospholipid transfer
EN18_15650	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EN18_15655	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EN18_15660	COG1127	ABC transporter
EN18_15670	COG0517	IMP dehydrogenase activity
EN18_15670	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EN18_15685	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EN18_15690	COG1137	ATPase activity
EN18_15700	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EN18_15705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EN18_15710	COG1660	Displays ATPase and GTPase activities
EN18_15715	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EN18_15720	COG2239	Acts as a magnesium transporter
EN18_15725	COG0312	modulator of DNA gyrase
EN18_15730	COG3028	Belongs to the UPF0307 family
EN18_15735	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
EN18_15740	COG1178	ABC-type Fe3 transport system permease component
EN18_15745	COG4143	(ABC) transporter
EN18_15750	COG0163	prenyltransferase activity
EN18_15755	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EN18_15760	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EN18_15765	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EN18_15770	COG2105	PFAM AIG2 family protein
EN18_15780	COG0729	surface antigen
EN18_15785	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EN18_15790	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
EN18_15805	COG1136	(ABC) transporter
EN18_15825	COG0529	Catalyzes the synthesis of activated sulfate
EN18_15830	COG2895	sulfate adenylyltransferase (ATP) activity
EN18_15835	COG0175	sulfate reduction
EN18_15840	COG1648	precorrin-2 dehydrogenase activity
EN18_15840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EN18_15855	COG0513	Belongs to the DEAD box helicase family
EN18_15860	COG2153	protein acetylation
EN18_15865	COG0697	spore germination
EN18_15870	COG3266	domain, Protein
EN18_15870	COG3061	Opacity-associated protein A
EN18_15875	COG0545	Peptidyl-prolyl cis-trans isomerase
EN18_15885	COG0203	ribosomal protein L17
EN18_15890	COG0202	RNA polymerase activity
EN18_15895	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EN18_15900	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EN18_15905	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EN18_15915	COG0201	protein transport
EN18_15920	COG0200	Binds to the 23S rRNA
EN18_15925	COG1841	ribosomal large subunit assembly
EN18_15930	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EN18_15935	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EN18_15940	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EN18_15945	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EN18_15950	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EN18_15955	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EN18_15960	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EN18_15965	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EN18_15970	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EN18_15975	COG0255	Belongs to the universal ribosomal protein uL29 family
EN18_15980	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EN18_15985	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EN18_15990	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EN18_15995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EN18_16000	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EN18_16005	COG0089	rRNA binding
EN18_16010	COG0088	Forms part of the polypeptide exit tunnel
EN18_16015	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EN18_16020	COG0051	transcription antitermination factor activity, RNA binding
EN18_16025	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EN18_16030	COG0557	exoribonuclease II activity
EN18_16035	COG3083	sulfuric ester hydrolase activity
EN18_16040	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
EN18_16045	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EN18_16055	COG1047	Peptidyl-prolyl cis-trans
EN18_16070	COG2249	NAD(P)H dehydrogenase (quinone) activity
EN18_16075	COG0488	(ABC) transporter
EN18_16085	COG0429	hydrolase of the alpha beta-hydrolase fold
EN18_16095	COG3954	Phosphoribulokinase
EN18_16100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EN18_16110	COG1012	belongs to the aldehyde dehydrogenase family
EN18_16120	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EN18_16130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EN18_16145	COG0180	Tryptophanyl-tRNA synthetase
EN18_16150	COG0546	phosphoglycolate phosphatase activity
EN18_16155	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EN18_16160	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EN18_16170	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EN18_16175	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EN18_16205	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EN18_16215	COG0678	peroxiredoxin activity
EN18_16215	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EN18_16220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EN18_16230	COG0165	Argininosuccinate lyase
EN18_16235	COG0137	argininosuccinate synthase activity
EN18_16240	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EN18_16245	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EN18_16250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EN18_16255	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EN18_16265	COG1045	serine acetyltransferase
EN18_16270	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EN18_16275	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EN18_16280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EN18_16285	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EN18_16290	COG1053	succinate dehydrogenase
EN18_16295	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EN18_16300	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EN18_16305	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EN18_16310	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EN18_16315	COG1509	lysine 2,3-aminomutase activity
EN18_16325	COG0459	protein refolding
EN18_16330	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EN18_16355	COG0149	triose-phosphate isomerase activity
EN18_16365	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EN18_16370	COG1575	Belongs to the MenA family. Type 1 subfamily
EN18_16375	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EN18_16380	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EN18_16385	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EN18_16390	COG1609	Transcriptional regulator
EN18_16395	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EN18_16400	COG0254	rRNA binding
EN18_16405	COG0281	malic enzyme
EN18_16410	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
EN18_16415	COG0626	cystathionine gamma-synthase activity
EN18_16420	COG0527	aspartate kinase activity
EN18_16420	COG0460	homoserine dehydrogenase
EN18_16430	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EN18_16435	COG3074	FtsZ-dependent cytokinesis
EN18_16440	COG1494	fructose-1,6-bisphosphatase
EN18_16445	COG0205	6-phosphofructokinase activity
EN18_16450	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EN18_16460	COG0745	RESPONSE REGULATOR receiver
EN18_16465	COG2205	protein histidine kinase activity
EN18_16475	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EN18_16480	COG3030	protein affecting phage T7 exclusion by the F plasmid
EN18_16485	COG3706	GGDEF domain
EN18_16490	COG1027	Aspartate ammonia-lyase
EN18_16495	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EN18_16510	COG4232	protein-disulfide reductase activity
EN18_16520	COG3263	regulation of cellular component size
EN18_16530	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EN18_16535	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EN18_16540	COG0194	GDP metabolic process
EN18_16545	COG1758	RNA polymerase activity
EN18_16550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EN18_16555	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EN18_16560	COG2233	PERMEase
EN18_16570	COG0745	RESPONSE REGULATOR receiver
EN18_16575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EN18_16580	COG2183	response to ionizing radiation
EN18_16590	COG0596	Alpha beta hydrolase
EN18_16595	COG1040	competence protein
EN18_16600	COG0316	Belongs to the HesB IscA family
EN18_16600	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EN18_16605	COG0494	nUDIX hydrolase
EN18_16610	COG1218	3'(2'),5'-bisphosphate nucleotidase
EN18_16620	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EN18_16625	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EN18_16630	COG3156	type II secretion system protein K
EN18_16635	COG4795	General secretion pathway protein
EN18_16640	COG2165	general secretion pathway protein
EN18_16645	COG2165	general secretion pathway protein
EN18_16650	COG2165	general secretion pathway protein
EN18_16655	COG1459	type II secretion system
EN18_16660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EN18_16670	COG3031	protein transport across the cell outer membrane
EN18_16675	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EN18_16680	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EN18_16685	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EN18_16695	COG0456	acetyltransferase
EN18_16700	COG1490	D-aminoacyl-tRNA deacylase activity
EN18_16725	COG0174	glutamine synthetase
EN18_16740	COG3852	Histidine kinase
EN18_16750	COG3300	MHYT domain
EN18_16750	COG5001	Diguanylate cyclase
EN18_16755	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EN18_16790	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EN18_16795	COG1404	Belongs to the peptidase S8 family
EN18_16800	COG4206	TonB-dependent receptor
EN18_16805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EN18_16820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EN18_16825	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EN18_16830	COG2177	Part of the ABC transporter FtsEX involved in
EN18_16835	COG2884	Cell division ATP-binding protein ftsE
EN18_16840	COG0552	protein localization to endoplasmic reticulum
EN18_16845	COG0742	ribosomal rna small subunit methyltransferase
EN18_16880	COG0783	Belongs to the Dps family
EN18_16885	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EN18_16890	COG1280	lysine exporter protein (LysE YggA)
EN18_16895	COG2267	carboxylic ester hydrolase activity
EN18_16900	COG0561	phosphatase activity
EN18_16915	COG3287	FIST C domain
EN18_16915	COG2199	diguanylate cyclase activity
EN18_16915	COG2200	EAL domain
EN18_16920	COG1011	Hydrolase
EN18_16925	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EN18_16935	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EN18_16940	COG0019	diaminopimelate decarboxylase activity
EN18_16950	COG1965	Belongs to the frataxin family
EN18_16955	COG3072	Adenylate cyclase
EN18_16965	COG0181	hydroxymethylbilane synthase activity
EN18_16970	COG1587	Uroporphyrinogen-III synthase
EN18_16975	COG2959	enzyme of heme biosynthesis
EN18_16980	COG3071	HemY protein
EN18_16985	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EN18_16995	COG3078	GTPase activator activity
EN18_17010	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EN18_17015	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EN18_17015	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EN18_17030	COG0084	hydrolase, TatD family'
EN18_17035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EN18_17050	COG0840	transmembrane signaling receptor activity
EN18_17055	COG1580	Controls the rotational direction of flagella during chemotaxis
EN18_17060	COG3161	chorismate lyase activity
EN18_17065	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EN18_17070	COG2937	Belongs to the GPAT DAPAT family
EN18_17075	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EN18_17085	COG0534	Mate efflux family protein
EN18_17090	COG1858	cytochrome C peroxidase
EN18_17095	COG0805	protein transport
EN18_17100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EN18_17105	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EN18_17110	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EN18_17120	COG2226	methyltransferase
EN18_17125	COG1322	Protein conserved in bacteria
EN18_17135	COG2081	HI0933 family
EN18_17145	COG1528	Iron-storage protein
EN18_17150	COG0589	response to stress
EN18_17155	COG0697	spore germination
EN18_17165	COG0742	ribosomal rna small subunit methyltransferase
EN18_17170	COG5002	protein histidine kinase activity
EN18_17170	COG5001	Diguanylate cyclase
EN18_17175	COG1522	sequence-specific DNA binding
EN18_17195	COG0006	proline dipeptidase activity
EN18_17195	COG0006	proline dipeptidase activity
EN18_17200	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EN18_17205	COG2022	thiamine diphosphate biosynthetic process
EN18_17210	COG2104	thiamine diphosphate biosynthetic process
EN18_17215	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EN18_17225	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EN18_17230	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EN18_17270	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EN18_17280	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EN18_17285	COG0408	coproporphyrinogen oxidase activity
EN18_17290	COG0009	L-threonylcarbamoyladenylate synthase
EN18_17295	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EN18_17300	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EN18_17305	COG0551	DNA topoisomerase type I activity
EN18_17310	COG2922	Belongs to the Smg family
EN18_17315	COG0758	DNA mediated transformation
EN18_17320	COG1652	LysM domain
EN18_17325	COG0242	peptide deformylase activity
EN18_17330	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EN18_17335	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EN18_17335	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EN18_17340	COG0569	domain protein
EN18_17345	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EN18_17355	COG1272	protein, Hemolysin III
EN18_17360	COG4326	sporulation control protein
EN18_17370	COG3084	Protein conserved in bacteria
EN18_17380	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EN18_17385	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EN18_17390	COG0204	Acyl-transferase
EN18_17395	COG0606	chelatase, subunit chli
EN18_17410	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EN18_17415	COG0129	dihydroxy-acid dehydratase activity
EN18_17425	COG0604	alcohol dehydrogenase
EN18_17435	COG0425	Belongs to the sulfur carrier protein TusA family
EN18_17445	COG2119	membrane
EN18_17450	COG0752	glycyl-tRNA synthetase alpha subunit
EN18_17455	COG0751	glycine-tRNA ligase activity
EN18_17460	COG3977	Valine--pyruvate aminotransferase
EN18_17465	COG0071	Belongs to the small heat shock protein (HSP20) family
EN18_17480	COG0187	DNA topoisomerase II activity
EN18_17485	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EN18_17490	COG0592	DNA-directed DNA polymerase activity
EN18_17495	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EN18_17510	COG1126	abc transporter atp-binding protein
EN18_17515	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EN18_17520	COG0594	ribonuclease P activity
EN18_17525	COG0706	membrane insertase activity
EN18_17530	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EN18_17535	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EN18_17540	COG0445	tRNA wobble uridine modification
EN18_17545	COG0357	Ribosomal RNA small subunit methyltransferase G
EN18_17550	COG1192	Involved in chromosome partitioning
EN18_17555	COG1475	DNA binding
EN18_17560	COG3312	ion transport
EN18_17565	COG0356	it plays a direct role in the translocation of protons across the membrane
EN18_17575	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EN18_17580	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EN18_17585	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EN18_17590	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EN18_17595	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EN18_17600	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EN18_17605	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EN18_17610	COG2814	Major facilitator Superfamily
EN18_17615	COG0583	DNA-binding transcription factor activity
EN18_17620	COG0183	Belongs to the thiolase family
EN18_17625	COG1250	3-hydroxyacyl-CoA dehydrogenase
EN18_17625	COG1024	Enoyl-CoA hydratase
EN18_17630	COG1739	Uncharacterized protein family UPF0029
EN18_17635	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EN18_17640	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
EN18_17685	COG0583	DNA-binding transcription factor activity
EN18_17690	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EN18_17695	COG2960	long-chain fatty acid transporting porin activity
EN18_17700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EN18_17705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EN18_17710	COG1309	transcriptional regulator
EN18_17760	COG0747	negative chemotaxis
EN18_17770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EN18_17780	COG2131	deaminase
EN18_17845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EN18_17850	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EN18_17860	COG0210	DNA helicase
EN18_17865	COG1280	lysine exporter protein (LysE YggA)
EN18_17880	COG2962	Rard protein
EN18_17885	COG0514	ATP-dependent DNA helicase (RecQ)
EN18_17900	COG1132	(ABC) transporter
EN18_17905	COG4774	siderophore transport
EN18_17910	COG1120	ATPase activity
EN18_17930	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EN18_17935	COG1263	PTS System
EN18_17935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EN18_17945	COG1561	YicC-like family, N-terminal region
EN18_17950	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EN18_17955	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EN18_17960	COG1560	Kdo2-lipid A biosynthetic process
EN18_17965	COG1560	Kdo2-lipid A biosynthetic process
EN18_17970	COG1309	transcriptional regulator
EN18_17975	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EN18_17990	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EN18_17995	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EN18_18005	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EN18_18010	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EN18_18015	COG0859	PFAM glycosyl transferase family 9
EN18_18020	COG0463	Glycosyl transferase, family 2
EN18_18025	COG0859	PFAM glycosyl transferase family 9
EN18_18030	COG3642	lipopolysaccharide core region biosynthetic process
EN18_18060	COG1519	Transferase
EN18_18095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EN18_18100	COG0662	Cupin 2, conserved barrel domain protein
EN18_18100	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
EN18_18105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EN18_18110	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
EN18_18140	COG0318	PFAM AMP-dependent synthetase and ligase
EN18_18145	COG1012	belongs to the aldehyde dehydrogenase family
EN18_18145	COG1454	alcohol dehydrogenase
EN18_18160	COG5433	transposase activity
EN18_18190	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EN18_18195	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EN18_18200	COG0668	transmembrane transport
EN18_18205	COG1573	uracil-dna glycosylase
EN18_18215	COG3068	Protein conserved in bacteria
EN18_18225	COG1940	carbohydrate kinase activity
EN18_18230	COG1253	flavin adenine dinucleotide binding
EN18_18235	COG0776	regulation of translation
EN18_18245	COG0151	Belongs to the GarS family
EN18_18250	COG0138	bifunctional purine biosynthesis protein purh
EN18_18260	COG0789	Transcriptional regulator
EN18_18265	COG3710	Transcriptional regulator
EN18_18270	COG0531	amino acid
EN18_18275	COG1982	Orn Lys Arg decarboxylase major
EN18_18280	COG0840	transmembrane signaling receptor activity
EN18_18300	COG0800	Aldolase
EN18_18310	COG3265	gluconokinase activity
EN18_18315	COG0129	dihydroxy-acid dehydratase activity
EN18_18320	COG1609	Transcriptional regulator
EN18_18325	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EN18_18330	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EN18_18335	COG2264	protein methyltransferase activity
EN18_18340	COG0439	Biotin carboxylase
EN18_18345	COG0511	ligase activity, forming carbon-carbon bonds
EN18_18350	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EN18_18355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EN18_18370	COG2814	Major facilitator Superfamily
EN18_18375	COG2205	protein histidine kinase activity
EN18_18375	COG0784	Response regulator, receiver
EN18_18380	COG0248	Ppx GppA phosphatase
EN18_18385	COG0513	Belongs to the DEAD box helicase family
EN18_18390	COG3118	belongs to the thioredoxin family
EN18_18395	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EN18_18405	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EN18_18450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EN18_18460	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EN18_18470	COG1072	(Pantothenic acid kinase))
EN18_18495	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EN18_18500	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EN18_18505	COG0250	Participates in transcription elongation, termination and antitermination
EN18_18510	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EN18_18515	COG0081	regulation of translation
EN18_18520	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EN18_18525	COG0222	ribosome binding
EN18_18530	COG0085	RNA polymerase activity
EN18_18535	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EN18_18540	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
EN18_18545	COG2816	NAD+ diphosphatase activity
EN18_18550	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EN18_18565	COG4942	peptidase
EN18_18570	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EN18_18580	COG0471	metal ion transport
EN18_18585	COG0688	phosphatidylethanolamine metabolic process
EN18_18590	COG1162	GTPase activity
EN18_18595	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EN18_18645	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EN18_18650	COG0802	atpase or kinase
EN18_18660	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EN18_18665	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EN18_18670	COG1923	regulation of RNA biosynthetic process
EN18_18675	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EN18_18680	COG0330	HflC and HflK could
EN18_18685	COG0330	HflC and HflK could
EN18_18690	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
EN18_18695	COG2900	Belongs to the SlyX family
EN18_18705	COG0545	Peptidyl-prolyl cis-trans isomerase
EN18_18710	COG2964	Protein conserved in bacteria
EN18_18715	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EN18_18720	COG2923	Belongs to the DsrF TusC family
EN18_18730	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EN18_18735	COG0049	tRNA binding
EN18_18740	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EN18_18745	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EN18_18750	COG2906	2 iron, 2 sulfur cluster binding
EN18_18760	COG0360	Binds together with S18 to 16S ribosomal RNA
EN18_18765	COG2965	DNA replication, synthesis of RNA primer
EN18_18770	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EN18_18775	COG0359	binds to the 23S rRNA
EN18_18785	COG0305	Participates in initiation and elongation during chromosome replication
EN18_18790	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EN18_18795	COG0432	Pfam Uncharacterised protein family UPF0047
EN18_18800	COG0166	Belongs to the GPI family
EN18_18815	COG0735	belongs to the Fur family
EN18_18820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EN18_18840	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EN18_18845	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EN18_18850	COG0175	sulfate reduction
EN18_18945	COG1410	methionine synthase
EN18_18945	COG0646	methionine synthase
EN18_18950	COG0527	aspartate kinase activity
EN18_18955	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EN18_18965	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EN18_18980	COG0629	single-stranded DNA binding
EN18_18985	COG2200	EAL domain
EN18_18985	COG2199	diguanylate cyclase activity
EN18_19010	COG3267	Type II secretory pathway component ExeA
EN18_19010	COG3409	Peptidoglycan-binding domain 1 protein
EN18_19020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EN18_19025	COG1459	type II secretion system
EN18_19070	COG1077	Cell shape determining protein MreB Mrl
EN18_19075	COG1792	Involved in formation and maintenance of cell shape
EN18_19080	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EN18_19085	COG0424	maF-like protein
EN18_19090	COG1530	ribonuclease E activity
EN18_19095	COG3164	Protein of unknown function
EN18_19100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EN18_19105	COG0312	modulator of DNA gyrase
EN18_19110	COG2235	arginine
EN18_19130	COG0589	response to stress
EN18_19145	COG1438	arginine binding
EN18_19150	COG0039	L-malate dehydrogenase activity
EN18_19155	COG0531	amino acid
EN18_19160	COG0531	amino acid
EN18_19165	COG0142	geranyltranstransferase activity
EN18_19170	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EN18_19175	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EN18_19180	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EN18_19185	COG2966	Psort location CytoplasmicMembrane, score
EN18_19190	COG3610	response to peptide
EN18_19200	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EN18_19205	COG2967	ApaG domain
EN18_19210	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EN18_19215	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EN18_19220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EN18_19225	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EN18_19230	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EN18_19285	COG0741	lytic transglycosylase activity
EN18_19290	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EN18_19295	COG1194	a g-specific adenine glycosylase
EN18_19300	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EN18_19305	COG2066	Belongs to the glutaminase family
EN18_19310	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EN18_19315	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EN18_19325	COG1872	DUF167
EN18_19330	COG0762	integral membrane protein
EN18_19335	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EN18_19340	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EN18_19360	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EN18_19365	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EN18_19370	COG1678	Uncharacterized ACR, COG1678
EN18_19375	COG0189	ligase activity
EN18_19380	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EN18_19385	COG2356	endonuclease I
EN18_19390	COG3091	SprT-like family
EN18_19395	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EN18_19405	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EN18_19410	COG0583	DNA-binding transcription factor activity
EN18_19415	COG4771	TonB-dependent receptor
EN18_19420	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EN18_19425	COG0126	phosphoglycerate kinase activity
EN18_19435	COG0191	fructose-bisphosphate aldolase activity
EN18_19445	COG0668	transmembrane transport
EN18_19450	COG1279	arginine transmembrane transporter activity
EN18_19455	COG0583	DNA-binding transcription factor activity
EN18_19465	COG0469	pyruvate kinase activity
EN18_19470	COG1349	DNA-binding transcription factor activity
EN18_19475	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EN18_19480	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EN18_19530	COG2207	Transcriptional regulator
EN18_19540	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EN18_19545	COG0582	viral genome integration into host DNA
EN18_19555	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EN18_19560	COG0358	DNA primase activity
EN18_19565	COG1610	YqeY-like protein
EN18_19570	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EN18_19575	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EN18_19585	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EN18_19590	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EN18_19595	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EN18_19600	COG1968	undecaprenyl-diphosphatase activity
EN18_19605	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EN18_19610	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EN18_19615	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EN18_19620	COG0585	pseudouridine synthase activity
EN18_19625	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EN18_19630	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EN18_19635	COG4942	peptidase
EN18_19635	COG1388	LysM domain
EN18_19640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EN18_19645	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EN18_19665	COG4208	sulfate ABC transporter
EN18_19670	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EN18_19680	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EN18_19685	COG2137	regulation of response to DNA damage stimulus
EN18_19690	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EN18_19695	COG0527	aspartate kinase activity
EN18_19700	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EN18_19750	COG3630	sodium ion export across plasma membrane
EN18_19755	COG5016	pyruvate
EN18_19755	COG0511	ligase activity, forming carbon-carbon bonds
EN18_19760	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EN18_19770	COG1238	metal cluster binding
EN18_19775	COG0612	Peptidase, M16
EN18_19780	COG2918	glutathione biosynthetic process
EN18_19785	COG1854	S-ribosylhomocysteine lyase activity
EN18_19790	COG4536	flavin adenine dinucleotide binding
EN18_19795	COG4137	Cytochrome C assembly protein
EN18_19800	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EN18_19805	COG0228	four-way junction DNA binding
EN18_19810	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EN18_19815	COG0336	Belongs to the RNA methyltransferase TrmD family
EN18_19820	COG0335	large ribosomal subunit rRNA binding
EN18_19825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EN18_19830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EN18_19840	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EN18_19845	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EN18_19850	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EN18_19855	COG0723	plastoquinol--plastocyanin reductase activity
EN18_19860	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EN18_19865	COG2857	Cytochrome c1
EN18_19870	COG0625	glutathione transferase activity
EN18_19875	COG2969	positive regulation of protein catabolic process
EN18_19880	COG2823	Periplasmic or secreted lipoprotein
EN18_19885	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EN18_19890	COG0792	nuclease activity
EN18_19895	COG3107	peptidoglycan biosynthetic process
EN18_19900	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EN18_19915	COG0288	reversible hydration of carbon dioxide
EN18_19920	COG0659	secondary active sulfate transmembrane transporter activity
EN18_19925	COG1131	(ABC) transporter
EN18_19930	COG0842	Transport permease protein
EN18_19935	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate