locus-tag	class	description
NH62_10001	COG2271	Major facilitator Superfamily
NH62_10002	COG0584	glycerophosphoryl diester phosphodiesterase
NH62_10004	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
NH62_10006	COG1609	Transcriptional regulator
NH62_10007	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NH62_10008	COG1879	ABC-type sugar transport system periplasmic component
NH62_10009	COG1172	Belongs to the binding-protein-dependent transport system permease family
NH62_10010	COG1129	ABC transporter
NH62_10011	COG1869	D-ribose catabolic process
NH62_10014	COG3501	Rhs element vgr protein
NH62_10032	COG0564	pseudouridine synthase activity
NH62_10034	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NH62_10035	COG2771	luxR family
NH62_10035	COG2200	EAL domain
NH62_10036	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NH62_10037	COG0673	inositol 2-dehydrogenase activity
NH62_10038	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NH62_10044	COG1342	Belongs to the UPF0251 family
NH62_10047	COG1301	dicarboxylic acid transport
NH62_10052	COG2814	Major facilitator Superfamily
NH62_10053	COG0583	DNA-binding transcription factor activity
NH62_10054	COG5001	Diguanylate cyclase
NH62_10054	COG3300	MHYT domain
NH62_10055	COG0739	heme binding
NH62_10057	COG0659	secondary active sulfate transmembrane transporter activity
NH62_10060	COG0745	RESPONSE REGULATOR receiver
NH62_10060	COG3706	GGDEF domain
NH62_10061	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NH62_10062	COG0581	inorganic phosphate transmembrane transporter activity
NH62_10063	COG0573	inorganic phosphate transmembrane transporter activity
NH62_10064	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NH62_10070	COG1770	oligopeptidase
NH62_10071	COG0513	Belongs to the DEAD box helicase family
NH62_10073	COG1388	LysM domain
NH62_10073	COG1376	ErfK ybiS ycfS ynhG family protein
NH62_10074	COG0415	Belongs to the DNA photolyase family
NH62_10076	COG3272	Protein of unknown function (DUF1722)
NH62_10077	COG0813	purine-nucleoside phosphorylase activity
NH62_10080	COG3706	GGDEF domain
NH62_10082	COG1566	PFAM secretion protein HlyD family protein
NH62_10086	COG0786	glutamate:sodium symporter activity
NH62_10089	COG1999	signal sequence binding
NH62_10091	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
NH62_10092	COG0671	phosphoesterase, PA-phosphatase related
NH62_10100	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
NH62_10101	COG0471	metal ion transport
NH62_10108	COG3501	Rhs element vgr protein
NH62_10110	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NH62_10111	COG1640	4-alpha-glucanotransferase
NH62_10112	COG0058	SHG alpha-glucan phosphorylase activity
NH62_10113	COG2909	trisaccharide binding
NH62_10116	COG2084	Dehydrogenase
NH62_10117	COG0217	transcriptional regulatory protein
NH62_10124	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NH62_10125	COG1444	tRNA N-acetyltransferase activity
NH62_10131	COG0745	RESPONSE REGULATOR receiver
NH62_10132	COG0642	Histidine kinase
NH62_10133	COG2194	sulfuric ester hydrolase activity
NH62_10134	COG4608	Belongs to the ABC transporter superfamily
NH62_10135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NH62_10136	COG0601	transmembrane transport
NH62_10140	COG0643	Histidine kinase
NH62_10140	COG2198	Histidine kinase
NH62_10141	COG0835	chemotaxis
NH62_10142	COG0835	chemotaxis
NH62_10143	COG0840	transmembrane signaling receptor activity
NH62_10144	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NH62_10145	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
NH62_10149	COG0745	RESPONSE REGULATOR receiver
NH62_10155	COG0259	pyridoxamine-phosphate oxidase activity
NH62_10158	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NH62_10163	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NH62_10168	COG1982	Orn Lys Arg decarboxylase major
NH62_10169	COG0531	amino acid
NH62_10170	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NH62_10171	COG1901	pseudouridine methyltransferase
NH62_10173	COG4221	oxidoreductase activity
NH62_10174	COG0840	transmembrane signaling receptor activity
NH62_10176	COG2910	NAD(P)H-binding
NH62_10178	COG1335	isochorismatase
NH62_10181	COG0697	spore germination
NH62_10186	COG0673	inositol 2-dehydrogenase activity
NH62_10187	COG3722	fumarate hydratase activity
NH62_10188	COG0246	Mannitol dehydrogenase
NH62_10189	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NH62_10189	COG2213	PTS system mannitol-specific
NH62_10191	COG0739	heme binding
NH62_10192	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NH62_10193	COG4597	amino acid ABC transporter
NH62_10194	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NH62_10196	COG1126	abc transporter atp-binding protein
NH62_10197	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NH62_10199	COG0840	transmembrane signaling receptor activity
NH62_10202	COG0840	transmembrane signaling receptor activity
NH62_10205	COG4580	involved in the transport of maltose and maltodextrins
NH62_10208	COG0363	glucosamine-6-phosphate deaminase activity
NH62_10213	COG2259	Doxx family
NH62_10214	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
NH62_10215	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NH62_10217	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NH62_10218	COG3366	ferrous iron transmembrane transporter activity
NH62_10219	COG0700	Nucleoside recognition
NH62_10221	COG0697	spore germination
NH62_10222	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
NH62_10223	COG1764	response to oxidative stress
NH62_10224	COG1846	Transcriptional regulator
NH62_10228	COG2207	Transcriptional regulator
NH62_10229	COG1280	lysine exporter protein (LysE YggA)
NH62_10231	COG1902	pentaerythritol trinitrate reductase activity
NH62_10233	COG1132	(ABC) transporter
NH62_10235	COG1902	pentaerythritol trinitrate reductase activity
NH62_10237	COG0583	DNA-binding transcription factor activity
NH62_10238	COG0513	Belongs to the DEAD box helicase family
NH62_10241	COG0840	transmembrane signaling receptor activity
NH62_10243	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NH62_10245	COG1304	FMN binding
NH62_10246	COG1620	l-lactate permease
NH62_10247	COG0583	DNA-binding transcription factor activity
NH62_10251	COG4172	Belongs to the ABC transporter superfamily
NH62_10253	COG1067	ATP-dependent peptidase activity
NH62_10254	COG0840	transmembrane signaling receptor activity
NH62_10256	COG2211	Major facilitator Superfamily
NH62_10258	COG3123	guanosine phosphorylase activity
NH62_10259	COG1741	Belongs to the pirin family
NH62_10261	COG5001	Diguanylate cyclase
NH62_10262	COG0583	DNA-binding transcription factor activity
NH62_10269	COG3706	GGDEF domain
NH62_10270	COG1846	Transcriptional regulator
NH62_10271	COG0784	Response regulator, receiver
NH62_10271	COG0835	chemotaxis
NH62_10272	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NH62_10273	COG2197	response regulator
NH62_10274	COG0393	Putative heavy-metal-binding
NH62_10277	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NH62_10278	COG3842	ATPase activity
NH62_10280	COG1175	transmembrane transport
NH62_10281	COG3833	ABC-type maltose transport systems, permease component
NH62_10284	COG1349	DNA-binding transcription factor activity
NH62_10285	COG3706	GGDEF domain
NH62_10287	COG2207	Transcriptional regulator
NH62_10287	COG4753	response regulator
NH62_10290	COG1278	Cold shock
NH62_10291	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NH62_10292	COG2354	Protein conserved in bacteria
NH62_10293	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NH62_10295	COG3152	Membrane
NH62_10297	COG0418	dihydroorotase activity
NH62_10298	COG3217	Mosc domain protein beta barrel domain protein
NH62_10298	COG3217	Mosc domain protein beta barrel domain protein
NH62_10298	COG0633	Ferredoxin
NH62_10298	COG0633	Ferredoxin
NH62_10305	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
NH62_10306	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NH62_10307	COG4558	Periplasmic binding protein
NH62_10308	COG0848	biopolymer transport protein
NH62_10309	COG0811	peptide transport
NH62_10310	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
NH62_10312	COG3721	Heme iron utilization protein
NH62_10313	COG0748	coenzyme F420 binding
NH62_10315	COG3835	regulator
NH62_10316	COG2610	gluconate transmembrane transporter activity
NH62_10317	COG1929	Belongs to the glycerate kinase type-1 family
NH62_10322	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NH62_10323	COG0363	glucosamine-6-phosphate deaminase activity
NH62_10324	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NH62_10325	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NH62_10326	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NH62_10330	COG0346	lactoylglutathione lyase activity
NH62_10332	COG2873	o-acetylhomoserine
NH62_10334	COG1063	alcohol dehydrogenase
NH62_10339	COG0582	viral genome integration into host DNA
NH62_10346	COG1802	Transcriptional regulator
NH62_10346	COG4626	Terminase
NH62_10352	COG1278	Cold shock
NH62_10357	COG0640	Transcriptional regulator
NH62_10358	COG0798	PFAM Bile acid sodium symporter
NH62_10381	COG2610	gluconate transmembrane transporter activity
NH62_10382	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NH62_10383	COG3622	Belongs to the hyi family
NH62_10384	COG0235	Class ii aldolase
NH62_10385	COG3395	kinase activity
NH62_10386	COG2084	Dehydrogenase
NH62_10387	COG1349	DNA-binding transcription factor activity
NH62_10389	COG3039	Transposase
NH62_10390	COG3048	D-serine ammonia-lyase activity
NH62_10393	COG1294	oxidase, subunit
NH62_10394	COG1271	oxidase subunit
NH62_10395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NH62_10396	COG1686	Belongs to the peptidase S11 family
NH62_10399	COG3047	cAMP biosynthetic process
NH62_10400	COG3227	Zinc metalloprotease (Elastase)
NH62_10402	COG2267	carboxylic ester hydrolase activity
NH62_10403	COG2067	long-chain fatty acid transport protein
NH62_10404	COG0366	Alpha amylase catalytic
NH62_10405	COG4989	oxidoreductase activity
NH62_10407	COG1136	(ABC) transporter
NH62_10408	COG1136	(ABC) transporter
NH62_10408	COG0577	efflux transmembrane transporter activity
NH62_10411	COG3275	phosphorelay sensor kinase activity
NH62_10412	COG3279	Response regulator of the LytR AlgR family
NH62_10414	COG3706	GGDEF domain
NH62_10415	COG0531	amino acid
NH62_10420	COG1765	OsmC-like protein
NH62_10421	COG1253	flavin adenine dinucleotide binding
NH62_10422	COG2171	N-acyltransferase activity
NH62_10425	COG0583	DNA-binding transcription factor activity
NH62_10426	COG2264	protein methyltransferase activity
NH62_10429	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NH62_10430	COG3186	Phenylalanine-4-hydroxylase
NH62_10431	COG2154	pterin-4-alpha-carbinolamine dehydratase
NH62_10432	COG0456	acetyltransferase
NH62_10433	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NH62_10434	COG0662	Cupin 2, conserved barrel domain protein
NH62_10435	COG0527	aspartate kinase activity
NH62_10437	COG0459	protein refolding
NH62_10438	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NH62_10439	COG2239	Acts as a magnesium transporter
NH62_10441	COG1166	arginine decarboxylase activity
NH62_10442	COG0010	Belongs to the arginase family
NH62_10444	COG3227	Zinc metalloprotease (Elastase)
NH62_10445	COG3397	chitin binding
NH62_10446	COG3046	protein related to deoxyribodipyrimidine photolyase
NH62_10448	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NH62_10450	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
NH62_10451	COG0513	Belongs to the DEAD box helicase family
NH62_10453	COG1368	sulfuric ester hydrolase activity
NH62_10454	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NH62_10457	COG0546	phosphoglycolate phosphatase activity
NH62_10467	COG1328	CTP reductase activity
NH62_10468	COG0602	queuosine metabolic process
NH62_10470	COG4067	protein conserved in archaea
NH62_10470	COG0189	ligase activity
NH62_10471	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NH62_10471	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NH62_10471	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
NH62_10472	COG1105	Belongs to the carbohydrate kinase PfkB family
NH62_10473	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NH62_10473	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NH62_10474	COG1609	Transcriptional regulator
NH62_10475	COG0420	3'-5' exonuclease activity
NH62_10476	COG0419	ATPase involved in DNA repair
NH62_10477	COG0784	Response regulator, receiver
NH62_10477	COG2205	protein histidine kinase activity
NH62_10478	COG0156	8-amino-7-oxononanoate synthase activity
NH62_10479	COG0156	8-amino-7-oxononanoate synthase activity
NH62_10481	COG0038	chloride channel
NH62_10482	COG0523	cobalamin synthesis protein
NH62_10484	COG3158	transport of potassium into the cell
NH62_10485	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NH62_10485	COG0674	pyruvate-flavodoxin oxidoreductase activity
NH62_10485	COG1013	pyruvate-flavodoxin oxidoreductase activity
NH62_10485	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NH62_10486	COG2205	protein histidine kinase activity
NH62_10487	COG0745	RESPONSE REGULATOR receiver
NH62_10488	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NH62_10489	COG0586	Pfam SNARE associated Golgi protein
NH62_10491	COG2200	EAL domain
NH62_10493	COG3038	cytochrome b561
NH62_10495	COG2116	formate transmembrane transporter activity
NH62_10496	COG0583	DNA-binding transcription factor activity
NH62_10498	COG3593	DNA synthesis involved in DNA repair
NH62_10499	COG0737	Belongs to the 5'-nucleotidase family
NH62_10501	COG0861	Integral membrane protein TerC family
NH62_10503	COG2824	Alkylphosphonate utilization operon protein PhnA
NH62_10513	COG3706	GGDEF domain
NH62_10516	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NH62_10517	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
NH62_10519	COG0745	RESPONSE REGULATOR receiver
NH62_10524	COG0023	Translation Initiation Factor
NH62_10526	COG1181	Belongs to the D-alanine--D-alanine ligase family
NH62_10528	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NH62_10528	COG1042	CoA-binding domain protein
NH62_10528	COG0045	succinate-CoA ligase (ADP-forming) activity
NH62_10529	COG0583	DNA-binding transcription factor activity
NH62_10530	COG4771	TonB-dependent receptor
NH62_10530	COG1629	transport
NH62_10535	COG2050	protein possibly involved in aromatic compounds catabolism
NH62_10539	COG0625	glutathione transferase activity
NH62_10542	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NH62_10543	COG4172	Belongs to the ABC transporter superfamily
NH62_10544	COG4239	(ABC) transporter, permease
NH62_10545	COG4174	ABC transporter (Permease)
NH62_10546	COG4166	transmembrane transport
NH62_10556	COG3842	ATPase activity
NH62_10557	COG1840	ABC-type Fe3 transport system, periplasmic component
NH62_10558	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NH62_10560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NH62_10561	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NH62_10562	COG1011	Hydrolase
NH62_10564	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
NH62_10565	COG1970	mechanosensitive ion channel activity
NH62_10566	COG2759	Belongs to the formate--tetrahydrofolate ligase family
NH62_10567	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NH62_10567	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NH62_10568	COG0302	gtp cyclohydrolase
NH62_10570	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NH62_10572	COG2897	thiosulfate sulfurtransferase activity
NH62_10574	COG2390	Transcriptional regulator
NH62_10575	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NH62_10576	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NH62_10582	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NH62_10587	COG0583	DNA-binding transcription factor activity
NH62_10588	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
NH62_10589	COG0778	Nitroreductase
NH62_10594	COG0640	Transcriptional regulator
NH62_10596	COG0446	pyridine nucleotide-disulphide oxidoreductase
NH62_10605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NH62_10605	COG1263	PTS System
NH62_10607	COG1621	beta-fructofuranosidase activity
NH62_10608	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NH62_10609	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NH62_10611	COG2885	chlorophyll binding
NH62_10612	COG0545	Peptidyl-prolyl cis-trans isomerase
NH62_10613	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NH62_10614	COG0840	transmembrane signaling receptor activity
NH62_10615	COG3069	C4-dicarboxylate transmembrane transporter activity
NH62_10616	COG1760	l-serine dehydratase
NH62_10620	COG1609	Transcriptional regulator
NH62_10621	COG2197	response regulator
NH62_10622	COG3850	Histidine kinase
NH62_10623	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NH62_10625	COG0243	molybdopterin cofactor binding
NH62_10629	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NH62_10630	COG2197	response regulator
NH62_10631	COG3851	Histidine kinase
NH62_10632	COG2271	Major facilitator Superfamily
NH62_10633	COG1840	ABC-type Fe3 transport system, periplasmic component
NH62_10635	COG3842	ATPase activity
NH62_10636	COG3243	poly(R)-hydroxyalkanoic acid synthase
NH62_10638	COG0183	Belongs to the thiolase family
NH62_10640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NH62_10641	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NH62_10644	COG3706	GGDEF domain
NH62_10645	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NH62_10647	COG1979	alcohol dehydrogenase
NH62_10650	COG4191	Histidine kinase
NH62_10651	COG1840	ABC-type Fe3 transport system, periplasmic component
NH62_10653	COG2271	Major facilitator Superfamily
NH62_10654	COG0469	pyruvate kinase activity
NH62_10655	COG2198	Histidine kinase
NH62_10655	COG0784	Response regulator, receiver
NH62_10655	COG2205	protein histidine kinase activity
NH62_10656	COG1879	ABC-type sugar transport system periplasmic component
NH62_10657	COG1803	Methylglyoxal synthase
NH62_10658	COG1335	isochorismatase
NH62_10659	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NH62_10662	COG0210	DNA helicase
NH62_10663	COG1289	transmembrane transporter activity
NH62_10669	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NH62_10670	COG4149	molybdate abc transporter
NH62_10671	COG0725	ABC transporter, periplasmic molybdate-binding protein
NH62_10672	COG1492	cobalamin metabolic process
NH62_10673	COG3039	Transposase
NH62_10679	COG5002	protein histidine kinase activity
NH62_10679	COG0784	Response regulator, receiver
NH62_10680	COG1879	ABC-type sugar transport system periplasmic component
NH62_10682	COG2827	Endonuclease containing a URI domain
NH62_10689	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NH62_10690	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NH62_10691	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
NH62_10692	COG0247	lactate metabolic process
NH62_10693	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NH62_10694	COG3118	belongs to the thioredoxin family
NH62_10699	COG4160	amino acid transport
NH62_10700	COG4215	(ABC) transporter
NH62_10701	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NH62_10702	COG1126	abc transporter atp-binding protein
NH62_10704	COG2425	protein containing a von Willebrand factor type A (vWA) domain
NH62_10706	COG0494	nUDIX hydrolase
NH62_10707	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
NH62_10709	COG1309	transcriptional regulator
NH62_10710	COG0513	Belongs to the DEAD box helicase family
NH62_10711	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
NH62_10713	COG0814	amino acid
NH62_10714	COG0840	transmembrane signaling receptor activity
NH62_10715	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NH62_10716	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NH62_10718	COG1984	allophanate hydrolase subunit 2
NH62_10721	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
NH62_10722	COG4181	ATPase activity
NH62_10724	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NH62_10725	COG1716	ATPase activity
NH62_10725	COG5001	Diguanylate cyclase
NH62_10727	COG0484	heat shock protein binding
NH62_10733	COG0346	lactoylglutathione lyase activity
NH62_10743	COG1943	Transposase
NH62_10755	COG3039	Transposase
NH62_10762	COG0346	lactoylglutathione lyase activity
NH62_10765	COG0110	maltose O-acetyltransferase activity
NH62_10766	COG3039	Transposase
NH62_10771	COG4977	sequence-specific DNA binding
NH62_10772	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
NH62_10782	COG3040	lipid binding
NH62_10802	COG3039	Transposase
NH62_10804	COG0346	lactoylglutathione lyase activity
NH62_10810	COG0384	phenazine biosynthesis protein PhzF
NH62_10811	COG3093	addiction module antidote protein HigA
NH62_10812	COG3549	Plasmid maintenance system killer
NH62_10827	COG3039	Transposase
NH62_10831	COG4977	sequence-specific DNA binding
NH62_10833	COG2801	Transposase and inactivated derivatives
NH62_10837	COG3039	Transposase
NH62_10838	COG1619	proteins homologs of microcin C7 resistance protein MccF
NH62_10841	COG0384	phenazine biosynthesis protein PhzF
NH62_10851	COG0346	lactoylglutathione lyase activity
NH62_10860	COG0346	lactoylglutathione lyase activity
NH62_10886	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NH62_10887	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NH62_10889	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NH62_10918	COG3772	lysozyme
NH62_10937	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NH62_10939	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NH62_10940	COG0509	glycine decarboxylation via glycine cleavage system
NH62_10941	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NH62_10941	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NH62_10942	COG1943	Transposase
NH62_10947	COG1686	Belongs to the peptidase S11 family
NH62_10950	COG2814	Major facilitator Superfamily
NH62_10953	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NH62_10958	COG5002	protein histidine kinase activity
NH62_10958	COG5000	phosphorelay sensor kinase activity
NH62_10959	COG0745	RESPONSE REGULATOR receiver
NH62_10964	COG0366	Alpha amylase catalytic
NH62_10965	COG3038	cytochrome b561
NH62_10971	COG0561	phosphatase activity
NH62_10972	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
NH62_10973	COG3623	hexulose-6-phosphate isomerase
NH62_10975	COG0745	RESPONSE REGULATOR receiver
NH62_10979	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NH62_10983	COG4604	ABC transporter, ATP-binding protein
NH62_10984	COG4605	iron ion homeostasis
NH62_10985	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NH62_10989	COG3291	Pkd domain containing protein
NH62_10989	COG4412	M6 family metalloprotease domain protein
NH62_10990	COG5380	lipid catabolic process
NH62_10991	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NH62_10992	COG0840	transmembrane signaling receptor activity
NH62_10994	COG3240	lipase activity
NH62_10995	COG3706	GGDEF domain
NH62_10996	COG2814	Major facilitator Superfamily
NH62_10997	COG1757	Na H antiporter
NH62_10999	COG4191	Histidine kinase
NH62_10999	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NH62_11000	COG0784	Response regulator, receiver
NH62_11000	COG3437	response regulator, receiver
NH62_11001	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NH62_11002	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NH62_11003	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
NH62_11004	COG0513	Belongs to the DEAD box helicase family
NH62_11006	COG0516	GMP reductase activity
NH62_11008	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NH62_11010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NH62_11011	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NH62_11011	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NH62_11016	COG3036	rescue of stalled ribosome
NH62_11017	COG1278	Cold shock
NH62_11018	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NH62_11018	COG1017	nitric oxide dioxygenase activity
NH62_11019	COG3604	Transcriptional regulator
NH62_11021	COG2195	Cleaves the N-terminal amino acid of tripeptides
NH62_11022	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NH62_11025	COG0840	transmembrane signaling receptor activity
NH62_11026	COG0714	Associated with various cellular activities
NH62_11030	COG2304	oxidoreductase activity
NH62_11033	COG1278	Cold shock
NH62_11034	COG5002	protein histidine kinase activity
NH62_11034	COG5001	Diguanylate cyclase
NH62_11036	COG3530	Putative quorum-sensing-regulated virulence factor
NH62_11037	COG3033	Beta-eliminating lyase
NH62_11038	COG0814	amino acid
NH62_11039	COG0589	response to stress
NH62_11041	COG2111	Na H antiporter
NH62_11041	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NH62_11045	COG2212	antiporter activity
NH62_11046	COG1320	monovalent cation:proton antiporter activity
NH62_11047	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NH62_11047	COG1017	nitric oxide dioxygenase activity
NH62_11048	COG0242	peptide deformylase activity
NH62_11050	COG0579	oxidoreductase
NH62_20001	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
NH62_20002	COG1194	a g-specific adenine glycosylase
NH62_20003	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NH62_20004	COG2066	Belongs to the glutaminase family
NH62_20005	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NH62_20006	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NH62_20008	COG1872	DUF167
NH62_20009	COG0762	integral membrane protein
NH62_20010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NH62_20011	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NH62_20015	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NH62_20016	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NH62_20017	COG1678	Uncharacterized ACR, COG1678
NH62_20018	COG0189	ligase activity
NH62_20019	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NH62_20020	COG2356	endonuclease I
NH62_20021	COG3091	SprT-like family
NH62_20022	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NH62_20023	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NH62_20024	COG0583	DNA-binding transcription factor activity
NH62_20025	COG4771	TonB-dependent receptor
NH62_20026	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NH62_20027	COG0126	phosphoglycerate kinase activity
NH62_20028	COG0191	fructose-bisphosphate aldolase activity
NH62_20029	COG0668	transmembrane transport
NH62_20030	COG1279	arginine transmembrane transporter activity
NH62_20031	COG0583	DNA-binding transcription factor activity
NH62_20034	COG0469	pyruvate kinase activity
NH62_20035	COG1349	DNA-binding transcription factor activity
NH62_20036	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NH62_20037	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
NH62_20040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NH62_20041	COG0358	DNA primase activity
NH62_20042	COG1610	YqeY-like protein
NH62_20043	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NH62_20044	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NH62_20046	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NH62_20047	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NH62_20048	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NH62_20049	COG1968	undecaprenyl-diphosphatase activity
NH62_20050	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NH62_20051	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NH62_20052	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NH62_20053	COG0585	pseudouridine synthase activity
NH62_20054	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NH62_20055	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NH62_20056	COG1388	LysM domain
NH62_20056	COG4942	peptidase
NH62_20057	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NH62_20058	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NH62_20062	COG4208	sulfate ABC transporter
NH62_20063	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NH62_20065	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NH62_20066	COG2137	regulation of response to DNA damage stimulus
NH62_20067	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NH62_20068	COG0527	aspartate kinase activity
NH62_20069	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
NH62_20078	COG3630	sodium ion export across plasma membrane
NH62_20079	COG5016	pyruvate
NH62_20079	COG0511	ligase activity, forming carbon-carbon bonds
NH62_20080	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
NH62_20082	COG1238	metal cluster binding
NH62_20083	COG0612	Peptidase, M16
NH62_20084	COG2918	glutathione biosynthetic process
NH62_20085	COG1854	S-ribosylhomocysteine lyase activity
NH62_20086	COG4536	flavin adenine dinucleotide binding
NH62_20087	COG4137	Cytochrome C assembly protein
NH62_20089	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NH62_20090	COG0228	four-way junction DNA binding
NH62_20091	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NH62_20092	COG0336	Belongs to the RNA methyltransferase TrmD family
NH62_20093	COG0335	large ribosomal subunit rRNA binding
NH62_20094	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NH62_20095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NH62_20097	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NH62_20098	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NH62_20099	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NH62_20100	COG0723	plastoquinol--plastocyanin reductase activity
NH62_20101	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NH62_20102	COG2857	Cytochrome c1
NH62_20103	COG0625	glutathione transferase activity
NH62_20104	COG2969	positive regulation of protein catabolic process
NH62_20105	COG2823	Periplasmic or secreted lipoprotein
NH62_20106	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NH62_20107	COG0792	nuclease activity
NH62_20108	COG3107	peptidoglycan biosynthetic process
NH62_20109	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NH62_20112	COG0288	reversible hydration of carbon dioxide
NH62_20113	COG0659	secondary active sulfate transmembrane transporter activity
NH62_20114	COG1131	(ABC) transporter
NH62_20115	COG0842	Transport permease protein
NH62_20116	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NH62_20117	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NH62_20118	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NH62_20120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NH62_20121	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NH62_20122	COG1489	DNA binding
NH62_20124	COG1643	Atp-dependent helicase
NH62_20125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NH62_20126	COG1752	Esterase of the alpha-beta hydrolase superfamily
NH62_20127	COG1049	propionate catabolic process, 2-methylcitrate cycle
NH62_20128	COG3112	Uncharacterised protein family (UPF0231)
NH62_20129	COG0347	Belongs to the P(II) protein family
NH62_20130	COG0004	ammonium transporteR
NH62_20131	COG1840	ABC-type Fe3 transport system, periplasmic component
NH62_20133	COG3842	ATPase activity
NH62_20137	COG2971	BadF BadG BcrA BcrD
NH62_20139	COG4608	Belongs to the ABC transporter superfamily
NH62_20140	COG0444	Belongs to the ABC transporter superfamily
NH62_20141	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NH62_20142	COG0601	transmembrane transport
NH62_20143	COG0747	negative chemotaxis
NH62_20145	COG2813	Specifically methylates the guanine in position
NH62_20146	COG0628	permease
NH62_20148	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NH62_20149	COG0316	Belongs to the HesB IscA family
NH62_20152	COG0739	heme binding
NH62_20153	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NH62_20154	COG2027	D-alanyl-D-alanine carboxypeptidase
NH62_20155	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
NH62_20156	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NH62_20157	COG1534	Rna-binding protein
NH62_20158	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
NH62_20159	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NH62_20160	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NH62_20161	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NH62_20163	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NH62_20166	COG0779	Required for maturation of 30S ribosomal subunits
NH62_20167	COG0195	Participates in both transcription termination and antitermination
NH62_20168	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NH62_20169	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NH62_20170	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NH62_20171	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NH62_20172	COG1185	polyribonucleotide nucleotidyltransferase activity
NH62_20173	COG4785	May be involved in cell division
NH62_20180	COG3153	acetyltransferase
NH62_20184	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NH62_20185	COG0513	Belongs to the DEAD box helicase family
NH62_20186	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NH62_20188	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NH62_20189	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NH62_20190	COG2204	response regulator
NH62_20192	COG0667	Aldo Keto reductase
NH62_20193	COG3066	DNA modification
NH62_20194	COG0494	nUDIX hydrolase
NH62_20195	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
NH62_20196	COG0730	response to heat
NH62_20197	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NH62_20198	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NH62_20199	COG1283	sodium-dependent phosphate transmembrane transporter activity
NH62_20200	COG0583	DNA-binding transcription factor activity
NH62_20201	COG0640	Transcriptional regulator
NH62_20202	COG0268	Binds directly to 16S ribosomal RNA
NH62_20203	COG0728	peptidoglycan biosynthetic process
NH62_20204	COG0196	riboflavin kinase activity
NH62_20205	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NH62_20206	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NH62_20207	COG1047	Peptidyl-prolyl cis-trans
NH62_20208	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NH62_20209	COG1966	Carbon starvation protein
NH62_20212	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NH62_20213	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NH62_20214	COG1472	Belongs to the glycosyl hydrolase 3 family
NH62_20215	COG3279	Response regulator of the LytR AlgR family
NH62_20216	COG3275	phosphorelay sensor kinase activity
NH62_20217	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NH62_20218	COG1605	Chorismate mutase
NH62_20218	COG0287	Prephenate dehydrogenase
NH62_20220	COG0488	(ABC) transporter
NH62_20222	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
NH62_20223	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
NH62_20224	COG5001	Diguanylate cyclase
NH62_20225	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NH62_20226	COG0077	Prephenate dehydratase
NH62_20226	COG1605	Chorismate mutase
NH62_20227	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NH62_20228	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NH62_20229	COG0564	pseudouridine synthase activity
NH62_20231	COG0542	response to heat
NH62_20239	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NH62_20241	COG2974	May be involved in recombination
NH62_20242	COG0745	RESPONSE REGULATOR receiver
NH62_20243	COG5002	protein histidine kinase activity
NH62_20245	COG0248	Ppx GppA phosphatase
NH62_20246	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NH62_20248	COG0581	inorganic phosphate transmembrane transporter activity
NH62_20249	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NH62_20252	COG3142	Participates in the control of copper homeostasis
NH62_20253	COG0450	alkyl hydroperoxide reductase
NH62_20254	COG0583	DNA-binding transcription factor activity
NH62_20255	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NH62_20257	COG0517	IMP dehydrogenase activity
NH62_20258	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NH62_20259	COG0343	queuine tRNA-ribosyltransferase activity
NH62_20260	COG1862	Preprotein translocase
NH62_20261	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NH62_20262	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NH62_20263	COG0483	inositol monophosphate 1-phosphatase activity
NH62_20265	COG1959	2 iron, 2 sulfur cluster binding
NH62_20266	COG1104	cysteine desulfurase activity
NH62_20267	COG0822	iron-sulfur transferase activity
NH62_20269	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
NH62_20271	COG0633	Ferredoxin
NH62_20272	COG2975	iron-sulfur cluster assembly
NH62_20273	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NH62_20274	COG0105	UTP biosynthetic process
NH62_20277	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NH62_20278	COG0124	histidyl-tRNA synthetase
NH62_20279	COG2976	Protein conserved in bacteria
NH62_20280	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NH62_20281	COG1160	GTP binding
NH62_20284	COG1570	exodeoxyribonuclease VII activity
NH62_20285	COG0516	GMP reductase activity
NH62_20285	COG0517	IMP dehydrogenase activity
NH62_20286	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NH62_20286	COG0519	Catalyzes the synthesis of GMP from XMP
NH62_20288	COG1584	GPR1 FUN34 yaaH family protein
NH62_20289	COG3433	isochorismatase activity
NH62_20289	COG1535	isochorismatase
NH62_20290	COG1021	2,3-dihydroxybenzoate-AMP ligase
NH62_20291	COG1169	isochorismate synthase
NH62_20292	COG1028	Short-chain dehydrogenase reductase Sdr
NH62_20294	COG4592	Periplasmic binding protein
NH62_20295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NH62_20296	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NH62_20297	COG1120	ATPase activity
NH62_20299	COG0583	DNA-binding transcription factor activity
NH62_20300	COG2015	COG2015, Alkyl sulfatase and related hydrolases
NH62_20301	COG1115	amino acid carrier protein
NH62_20302	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NH62_20303	COG0583	DNA-binding transcription factor activity
NH62_20306	COG4565	transcriptional regulatory protein
NH62_20308	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
NH62_20309	COG5016	pyruvate
NH62_20309	COG0511	ligase activity, forming carbon-carbon bonds
NH62_20310	COG3630	sodium ion export across plasma membrane
NH62_20312	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
NH62_20313	COG3052	prosthetic group binding
NH62_20314	COG2301	Belongs to the HpcH HpaI aldolase family
NH62_20315	COG3051	citrate lyase alpha subunit
NH62_20316	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
NH62_20317	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
NH62_20319	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NH62_20320	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NH62_20321	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
NH62_20330	COG3039	Transposase
NH62_20343	COG1012	belongs to the aldehyde dehydrogenase family
NH62_20347	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
NH62_20348	COG0840	transmembrane signaling receptor activity
NH62_20349	COG3710	Transcriptional regulator
NH62_20354	COG4796	Type ii and iii secretion system protein
NH62_20358	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NH62_20359	COG1459	type II secretion system
NH62_20361	COG2207	Transcriptional regulator
NH62_20362	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NH62_20367	COG0739	heme binding
NH62_20369	COG3064	Membrane
NH62_20370	COG0582	viral genome integration into host DNA
NH62_20371	COG0582	viral genome integration into host DNA
NH62_20373	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NH62_20374	COG2867	negative regulation of translational initiation
NH62_20375	COG2914	Belongs to the UPF0125 (RnfH) family
NH62_20376	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NH62_20377	COG0497	DNA recombination
NH62_20378	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NH62_20379	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NH62_20380	COG0443	Heat shock 70 kDa protein
NH62_20381	COG0484	heat shock protein binding
NH62_20387	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
NH62_20388	COG0590	tRNA wobble adenosine to inosine editing
NH62_20390	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
NH62_20391	COG0047	phosphoribosylformylglycinamidine synthase activity
NH62_20391	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NH62_20392	COG1943	Transposase
NH62_20396	COG0442	prolyl-tRNA aminoacylation
NH62_20397	COG1720	tRNA m6t6A37 methyltransferase activity
NH62_20398	COG0254	rRNA binding
NH62_20399	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NH62_20400	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
NH62_20401	COG1671	Belongs to the UPF0178 family
NH62_20403	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NH62_20406	COG3098	single-species biofilm formation
NH62_20407	COG0564	pseudouridine synthase activity
NH62_20408	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NH62_20409	COG0142	geranyltranstransferase activity
NH62_20410	COG1722	exodeoxyribonuclease VII activity
NH62_20411	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NH62_20413	COG0301	tRNA thio-modification
NH62_20413	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NH62_20414	COG0583	DNA-binding transcription factor activity
NH62_20415	COG0583	DNA-binding transcription factor activity
NH62_20416	COG2363	Small membrane protein
NH62_20417	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NH62_20418	COG1611	Belongs to the LOG family
NH62_20419	COG3706	GGDEF domain
NH62_20421	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NH62_20421	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NH62_20423	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
NH62_20424	COG1464	Belongs to the NlpA lipoprotein family
NH62_20425	COG2011	ABC-type metal ion transport system permease component
NH62_20426	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NH62_20427	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NH62_20428	COG1609	Transcriptional regulator
NH62_20429	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NH62_20429	COG1263	PTS System
NH62_20430	COG0366	Alpha amylase catalytic
NH62_20435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NH62_20436	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NH62_20437	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NH62_20438	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NH62_20439	COG0110	maltose O-acetyltransferase activity
NH62_20443	COG1045	serine acetyltransferase
NH62_20445	COG0438	transferase activity, transferring glycosyl groups
NH62_20447	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
NH62_20453	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NH62_20455	COG1596	polysaccharide export
NH62_20460	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NH62_20462	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NH62_20463	COG0321	lipoyl(octanoyl) transferase activity
NH62_20464	COG2921	Belongs to the UPF0250 family
NH62_20465	COG1686	Belongs to the peptidase S11 family
NH62_20466	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NH62_20467	COG0772	Belongs to the SEDS family
NH62_20468	COG0768	penicillin binding
NH62_20469	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NH62_20470	COG0799	negative regulation of ribosome biogenesis
NH62_20471	COG1466	dna polymerase III delta subunit
NH62_20472	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
NH62_20473	COG0495	leucyl-tRNA aminoacylation
NH62_20474	COG2888	peptidyl-tyrosine sulfation
NH62_20475	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NH62_20476	COG4535	Mg2 and Co2 transporter CorC
NH62_20477	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NH62_20478	COG1702	phosphate starvation-inducible protein PhoH
NH62_20479	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NH62_20480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NH62_20481	COG2190	(PTS) system
NH62_20483	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NH62_20484	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NH62_20485	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
NH62_20486	COG3115	cell septum assembly
NH62_20487	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NH62_20490	COG0789	Transcriptional regulator
NH62_20491	COG1585	Membrane protein implicated in regulation of membrane protease activity
NH62_20492	COG0330	HflC and HflK could
NH62_20493	COG3118	belongs to the thioredoxin family
NH62_20494	COG3039	Transposase
NH62_20495	COG0300	oxidoreductase activity
NH62_20496	COG1090	epimerase
NH62_20497	COG0622	Phosphoesterase
NH62_20500	COG3710	Transcriptional regulator
NH62_20501	COG0326	Molecular chaperone. Has ATPase activity
NH62_20502	COG0563	adenylate kinase activity
NH62_20503	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NH62_20506	COG0367	asparagine synthase
NH62_20507	COG4651	solute:proton antiporter activity
NH62_20507	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NH62_20508	COG1940	carbohydrate kinase activity
NH62_20508	COG1846	Transcriptional regulator
NH62_20509	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NH62_20510	COG1263	PTS System
NH62_20510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NH62_20510	COG2190	(PTS) system
NH62_20511	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NH62_20513	COG0101	tRNA pseudouridine synthase activity
NH62_20514	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NH62_20515	COG0285	dihydrofolate synthase activity
NH62_20516	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
NH62_20517	COG1286	toxin biosynthetic process
NH62_20518	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NH62_20519	COG2056	Na+-H+ antiporter family
NH62_20520	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NH62_20523	COG0346	lactoylglutathione lyase activity
NH62_20524	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NH62_20525	COG4660	Part of a membrane complex involved in electron transport
NH62_20526	COG4659	FMN binding
NH62_20527	COG4658	electron transport chain
NH62_20528	COG4656	Part of a membrane complex involved in electron transport
NH62_20529	COG2878	Part of a membrane complex involved in electron transport
NH62_20530	COG4657	Part of a membrane complex involved in electron transport
NH62_20532	COG0556	nucleotide-excision repair
NH62_20533	COG2204	response regulator
NH62_20534	COG2198	Histidine kinase
NH62_20535	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NH62_20536	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NH62_20537	COG0521	Mo-molybdopterin cofactor biosynthetic process
NH62_20538	COG0315	cyclic pyranopterin monophosphate synthase activity
NH62_20539	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NH62_20540	COG0314	molybdopterin synthase activity
NH62_20541	COG2199	diguanylate cyclase activity
NH62_20542	COG4109	DRTGG domain
NH62_20544	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
NH62_20545	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
NH62_20547	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NH62_20547	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NH62_20548	COG0489	protein tyrosine kinase activity
NH62_20549	COG0572	uridine kinase
NH62_20550	COG2982	Protein involved in outer membrane biogenesis
NH62_20551	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
NH62_20552	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NH62_20554	COG2067	long-chain fatty acid transport protein
NH62_20557	COG0183	Belongs to the thiolase family
NH62_20558	COG1024	Enoyl-CoA hydratase
NH62_20558	COG1250	3-hydroxyacyl-CoA dehydrogenase
NH62_20559	COG0778	Nitroreductase
NH62_20560	COG0583	DNA-binding transcription factor activity
NH62_20561	COG0745	RESPONSE REGULATOR receiver
NH62_20563	COG2832	Protein of unknown function (DUF454)
NH62_20564	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NH62_20565	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NH62_20566	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NH62_20567	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NH62_20570	COG1028	Short-chain dehydrogenase reductase Sdr
NH62_20571	COG0616	signal peptide processing
NH62_20573	COG1522	sequence-specific DNA binding
NH62_20574	COG1946	Acyl-CoA thioesterase
NH62_20578	COG3706	GGDEF domain
NH62_20579	COG0640	Transcriptional regulator
NH62_20580	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NH62_20585	COG1881	PFAM PEBP family protein
NH62_20588	COG0009	L-threonylcarbamoyladenylate synthase
NH62_20591	COG2201	protein-glutamate methylesterase activity
NH62_20593	COG5002	protein histidine kinase activity
NH62_20594	COG4191	Histidine kinase
NH62_20595	COG5001	Diguanylate cyclase
NH62_20595	COG3300	MHYT domain
NH62_20596	COG2204	response regulator
NH62_20598	COG4191	Histidine kinase
NH62_20601	COG0601	transmembrane transport
NH62_20602	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NH62_20603	COG0444	Belongs to the ABC transporter superfamily
NH62_20604	COG4608	Belongs to the ABC transporter superfamily
NH62_20605	COG0435	Glutathione S-transferase
NH62_20606	COG0280	phosphate acetyltransferase
NH62_20606	COG0857	belongs to the CobB CobQ family
NH62_20607	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NH62_20608	COG3092	negative regulation of chromosome organization
NH62_20609	COG4628	conserved protein (DUF2132)
NH62_20611	COG4120	Belongs to the binding-protein-dependent transport system permease family
NH62_20613	COG2203	Gaf domain
NH62_20613	COG2199	diguanylate cyclase activity
NH62_20614	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NH62_20616	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NH62_20617	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NH62_20618	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NH62_20619	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NH62_20620	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NH62_20621	COG0156	8-amino-7-oxononanoate synthase activity
NH62_20622	COG2226	methyltransferase
NH62_20623	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NH62_20625	COG0501	Belongs to the peptidase M48B family
NH62_20627	COG0300	oxidoreductase activity
NH62_20630	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NH62_20632	COG2268	Band 7 protein
NH62_20634	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NH62_20635	COG2915	High frequency lysogenization protein hflD homolog
NH62_20636	COG0482	sulfurtransferase activity
NH62_20637	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NH62_20638	COG2916	Histone family protein nucleoid-structuring protein H-NS
NH62_20639	COG1757	Na H antiporter
NH62_20640	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NH62_20641	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NH62_20642	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NH62_20643	COG0131	Imidazoleglycerol-phosphate dehydratase
NH62_20643	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NH62_20644	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NH62_20645	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NH62_20646	COG0107	imidazoleglycerol-phosphate synthase activity
NH62_20647	COG0140	phosphoribosyl-ATP diphosphatase activity
NH62_20647	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NH62_20648	COG1187	pseudouridine synthase activity
NH62_20650	COG1278	Cold shock
NH62_20651	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NH62_20652	COG0542	response to heat
NH62_20654	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NH62_20655	COG1012	belongs to the aldehyde dehydrogenase family
NH62_20655	COG1454	alcohol dehydrogenase
NH62_20656	COG1737	Transcriptional regulator
NH62_20657	COG0076	glutamate decarboxylase activity
NH62_20659	COG2431	L-lysine efflux transmembrane transporter activity
NH62_20661	COG3070	regulator of competence-specific genes
NH62_20664	COG3852	Histidine kinase
NH62_20666	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NH62_20669	COG0189	ligase activity
NH62_20669	COG4067	protein conserved in archaea
NH62_20670	COG0500	methyltransferase
NH62_20671	COG4106	trans-aconitate 2-methyltransferase activity
NH62_20672	COG1801	Protein of unknown function DUF72
NH62_20673	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NH62_20674	COG1435	thymidine kinase activity
NH62_20676	COG0159	tryptophan synthase activity
NH62_20677	COG0133	tryptophan synthase activity
NH62_20678	COG0134	indole-3-glycerol-phosphate synthase activity
NH62_20678	COG0135	phosphoribosylanthranilate isomerase activity
NH62_20679	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NH62_20680	COG0512	Glutamine amidotransferase of anthranilate synthase
NH62_20681	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NH62_20682	COG0613	PHP domain protein
NH62_20683	COG0009	L-threonylcarbamoyladenylate synthase
NH62_20684	COG1187	pseudouridine synthase activity
NH62_20685	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NH62_20686	COG4988	ABC transporter
NH62_20687	COG0492	ferredoxin-NADP+ reductase activity
NH62_20690	COG3706	GGDEF domain
NH62_20691	COG2949	membrane
NH62_20693	COG0281	malic enzyme
NH62_20695	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NH62_20699	COG2885	chlorophyll binding
NH62_20702	COG0277	FAD linked oxidase domain protein
NH62_20702	COG0247	lactate metabolic process
NH62_20706	COG2986	histidine ammonia-lyase
NH62_20707	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NH62_20708	COG0010	Belongs to the arginase family
NH62_20709	COG1228	amidohydrolase
NH62_20713	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NH62_20715	COG5001	Diguanylate cyclase
NH62_20716	COG0417	DNA replication proofreading
NH62_20717	COG2197	response regulator
NH62_20718	COG0322	excinuclease ABC activity
NH62_20724	COG3706	GGDEF domain
NH62_20724	COG0745	RESPONSE REGULATOR receiver
NH62_20726	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NH62_20727	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NH62_20727	COG0072	phenylalanine-tRNA ligase activity
NH62_20728	COG0776	regulation of translation
NH62_20731	COG0500	methyltransferase
NH62_20732	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
NH62_20734	COG0295	cytidine deaminase activity
NH62_20735	COG1346	cytolysis
NH62_20737	COG2925	Exonuclease
NH62_20739	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NH62_20740	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NH62_20741	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
NH62_20744	COG2988	succinylglutamate desuccinylase activity
NH62_20745	COG4139	cobalamin transport
NH62_20746	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
NH62_20755	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NH62_20756	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NH62_20757	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NH62_20761	COG2814	Major facilitator Superfamily
NH62_20763	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NH62_20769	COG3108	Peptidase M15
NH62_20770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NH62_20773	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
NH62_20778	COG1846	Transcriptional regulator
NH62_20779	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NH62_20780	COG0726	polysaccharide deacetylase
NH62_20781	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NH62_20783	COG1447	Phosphotransferase system cellobiose-specific component IIA
NH62_20784	COG1486	melibiose metabolic process
NH62_20785	COG3394	polysaccharide catabolic process
NH62_20786	COG1609	Transcriptional regulator
NH62_20787	COG2943	transferase activity, transferring hexosyl groups
NH62_20788	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
NH62_20789	COG0840	transmembrane signaling receptor activity
NH62_20792	COG1448	Aminotransferase
NH62_20793	COG3437	response regulator, receiver
NH62_20793	COG2770	Histidine kinase
NH62_20794	COG0351	phosphomethylpyrimidine kinase
NH62_20794	COG0352	thiamine-phosphate diphosphorylase activity
NH62_20795	COG0017	Asparaginyl-tRNA synthetase
NH62_20797	COG0720	synthase
NH62_20798	COG1760	l-serine dehydratase
NH62_20799	COG0814	amino acid
NH62_20800	COG0494	nUDIX hydrolase
NH62_20801	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NH62_20804	COG3106	COG3106 Predicted ATPase
NH62_20805	COG3768	UPF0283 membrane protein
NH62_20806	COG3283	Transcriptional regulator of aromatic amino acids metabolism
NH62_20807	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NH62_20810	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NH62_20812	COG0471	metal ion transport
NH62_20813	COG4191	Histidine kinase
NH62_20813	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NH62_20815	COG2990	Protein conserved in bacteria
NH62_20816	COG3713	MltA-interacting MipA family protein
NH62_20817	COG2205	protein histidine kinase activity
NH62_20818	COG0745	RESPONSE REGULATOR receiver
NH62_20823	COG1129	ABC transporter
NH62_20825	COG3039	Transposase
NH62_20830	COG2186	Transcriptional regulator
NH62_20831	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NH62_20832	COG0372	Belongs to the citrate synthase family
NH62_20838	COG2195	Cleaves the N-terminal amino acid of tripeptides
NH62_20840	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
NH62_20843	COG0625	glutathione transferase activity
NH62_20844	COG3437	response regulator, receiver
NH62_20845	COG3437	response regulator, receiver
NH62_20846	COG4999	Histidine kinase
NH62_20846	COG2205	protein histidine kinase activity
NH62_20846	COG3850	Histidine kinase
NH62_20846	COG3437	response regulator, receiver
NH62_20848	COG3706	GGDEF domain
NH62_20849	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NH62_20850	COG1254	Belongs to the acylphosphatase family
NH62_20851	COG2920	part of a sulfur-relay system
NH62_20852	COG0670	Belongs to the BI1 family
NH62_20853	COG1126	abc transporter atp-binding protein
NH62_20854	COG0765	amino acid transport
NH62_20855	COG4597	amino acid ABC transporter
NH62_20856	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NH62_20858	COG0561	phosphatase activity
NH62_20860	COG0602	queuosine metabolic process
NH62_20861	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NH62_20867	COG3706	GGDEF domain
NH62_20868	COG0443	Heat shock 70 kDa protein
NH62_20869	COG0443	Heat shock 70 kDa protein
NH62_20876	COG1643	Atp-dependent helicase
NH62_20878	COG0443	Heat shock 70 kDa protein
NH62_20879	COG0095	Lipoate-protein ligase
NH62_20880	COG0583	DNA-binding transcription factor activity
NH62_20881	COG0477	Major facilitator Superfamily
NH62_20882	COG0415	Belongs to the DNA photolyase family
NH62_20883	COG2076	Multidrug Resistance protein
NH62_20887	COG2198	Histidine kinase
NH62_20887	COG0643	Histidine kinase
NH62_20889	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NH62_20891	COG2201	protein-glutamate methylesterase activity
NH62_20892	COG0835	chemotaxis
NH62_20893	COG0840	transmembrane signaling receptor activity
NH62_20893	COG3290	protein histidine kinase activity
NH62_20894	COG0840	transmembrane signaling receptor activity
NH62_20896	COG0513	Belongs to the DEAD box helicase family
NH62_20899	COG1566	PFAM secretion protein HlyD family protein
NH62_20900	COG2814	Major facilitator Superfamily
NH62_20902	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
NH62_20904	COG3501	Rhs element vgr protein
NH62_20908	COG1280	lysine exporter protein (LysE YggA)
NH62_20909	COG1115	amino acid carrier protein
NH62_20912	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NH62_20913	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NH62_20914	COG1177	transmembrane transport
NH62_20915	COG1176	ABC-type spermidine putrescine transport system, permease component I
NH62_20916	COG3842	ATPase activity
NH62_20920	COG0037	tRNA processing
NH62_20921	COG0589	response to stress
NH62_20922	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NH62_20925	COG2217	Heavy metal translocating P-type atpase
NH62_20927	COG2010	Cytochrome c
NH62_20930	COG3278	Belongs to the heme-copper respiratory oxidase family
NH62_20933	COG0784	Response regulator, receiver
NH62_20933	COG2205	protein histidine kinase activity
NH62_20938	COG2994	toxin metabolic process
NH62_20939	COG3064	Membrane
NH62_20939	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
NH62_20939	COG1073	alpha beta
NH62_20942	COG3120	sequence-specific DNA binding
NH62_20943	COG1067	ATP-dependent peptidase activity
NH62_20944	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NH62_20949	COG0116	Belongs to the methyltransferase superfamily
NH62_20949	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NH62_20952	COG0167	dihydroorotate dehydrogenase activity
NH62_20954	COG0308	aminopeptidase N
NH62_20957	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
NH62_20958	COG1956	GAF domain-containing protein
NH62_20959	COG1132	(ABC) transporter
NH62_20960	COG2995	paraquat-inducible protein a
NH62_20961	COG3008	intermembrane lipid transfer
NH62_20962	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NH62_20962	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
NH62_20963	COG2996	Protein conserved in bacteria
NH62_20966	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NH62_20968	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NH62_20971	COG0437	4 iron, 4 sulfur cluster binding
NH62_20972	COG3383	formate dehydrogenase (NAD+) activity
NH62_20972	COG0243	molybdopterin cofactor binding
NH62_20978	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NH62_20980	COG0488	(ABC) transporter
NH62_20981	COG3852	Histidine kinase
NH62_20982	COG2204	response regulator
NH62_20984	COG4662	Binding-protein-dependent transport system inner membrane component
NH62_20985	COG3842	ATPase activity
NH62_20986	COG0746	molybdenum cofactor guanylyltransferase activity
NH62_20989	COG1940	carbohydrate kinase activity
NH62_20992	COG0840	transmembrane signaling receptor activity
NH62_20993	COG0791	NLP P60 protein
NH62_20997	COG0534	Mate efflux family protein
NH62_20999	COG1793	dna ligase
NH62_21002	COG0848	biopolymer transport protein
NH62_21003	COG0811	peptide transport
NH62_21004	COG0811	peptide transport
NH62_21007	COG1175	transmembrane transport
NH62_21008	COG0395	ABC-type sugar transport system, permease component
NH62_21009	COG3842	ATPase activity
NH62_21010	COG1349	DNA-binding transcription factor activity
NH62_21011	COG0584	glycerophosphoryl diester phosphodiesterase
NH62_21012	COG2731	YhcH YjgK YiaL family protein
NH62_21013	COG0251	oxidation-reduction process
NH62_21014	COG1609	Transcriptional regulator
NH62_21015	COG2723	6-phospho-beta-galactosidase activity
NH62_21016	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
NH62_21017	COG0583	DNA-binding transcription factor activity
NH62_21021	COG0577	efflux transmembrane transporter activity
NH62_21021	COG1136	(ABC) transporter
NH62_21022	COG0577	efflux transmembrane transporter activity
NH62_21022	COG1136	(ABC) transporter
NH62_21023	COG1136	(ABC) transporter
NH62_21023	COG4591	ABC-type transport system involved in lipoprotein release permease component
NH62_21024	COG1294	oxidase, subunit
NH62_21025	COG1271	oxidase subunit
NH62_21033	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NH62_21038	COG0753	catalase activity
NH62_21041	COG3527	Alpha-acetolactate decarboxylase
NH62_21044	COG2200	EAL domain
NH62_21044	COG2199	diguanylate cyclase activity
NH62_21045	COG3706	GGDEF domain
NH62_21046	COG2017	converts alpha-aldose to the beta-anomer
NH62_21047	COG2017	converts alpha-aldose to the beta-anomer
NH62_21048	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NH62_21049	COG1085	galactose-1-phosphate uridylyltransferase
NH62_21054	COG3706	GGDEF domain
NH62_21054	COG0745	RESPONSE REGULATOR receiver
NH62_21057	COG0784	Response regulator, receiver
NH62_21057	COG0835	chemotaxis
NH62_21059	COG4565	transcriptional regulatory protein
NH62_21060	COG3290	protein histidine kinase activity
NH62_21063	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NH62_21067	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
NH62_21068	COG3063	Type IV pilus biogenesis stability protein PilW
NH62_21071	COG1451	nucleotide metabolic process
NH62_21073	COG0583	DNA-binding transcription factor activity
NH62_21077	COG1538	Outer membrane efflux protein
NH62_21079	COG0019	diaminopimelate decarboxylase activity
NH62_21080	COG1748	Saccharopine dehydrogenase
NH62_21082	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NH62_21085	COG4181	ATPase activity
NH62_21086	COG0534	Mate efflux family protein
NH62_21087	COG0702	epimerase
NH62_21089	COG2814	Major facilitator Superfamily
NH62_21090	COG1187	pseudouridine synthase activity
NH62_21091	COG1061	Type III restriction enzyme res subunit
NH62_21094	COG5002	protein histidine kinase activity
NH62_21095	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NH62_21096	COG3706	GGDEF domain
NH62_21096	COG4251	negative regulation of phosphorylation
NH62_21096	COG5001	Diguanylate cyclase
NH62_21096	COG2203	Gaf domain
NH62_21098	COG0840	transmembrane signaling receptor activity
NH62_21104	COG4934	collagen metabolic process
NH62_21108	COG2239	Acts as a magnesium transporter
NH62_21110	COG0814	amino acid
NH62_21111	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NH62_21112	COG1131	(ABC) transporter
NH62_21113	COG0842	Transport permease protein
NH62_21115	COG3313	Fe-S protein
NH62_21117	COG4134	Bacterial extracellular solute-binding protein
NH62_21118	COG4135	transport system, permease component
NH62_21119	COG4136	ATPase activity
NH62_21120	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NH62_21121	COG0564	pseudouridine synthase activity
NH62_21122	COG0733	neurotransmitter:sodium symporter activity
NH62_21124	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NH62_21125	COG0626	cystathionine gamma-synthase activity
NH62_21126	COG2818	Glycosylase
NH62_21129	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NH62_21132	COG1842	Phage shock protein A
NH62_21133	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NH62_21135	COG4168	peptide transport system, permease
NH62_21136	COG4171	peptide transport system, permease
NH62_21138	COG4172	Belongs to the ABC transporter superfamily
NH62_21141	COG1227	inorganic diphosphatase activity
NH62_21145	COG0243	molybdopterin cofactor binding
NH62_21146	COG3005	denitrification pathway
NH62_21147	COG4459	periplasmic nitrate reductase
NH62_21148	COG2116	formate transmembrane transporter activity
NH62_21150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NH62_21151	COG1434	Gram-negative-bacterium-type cell wall biogenesis
NH62_21153	COG2917	probably involved in intracellular septation
NH62_21154	COG1607	acyl-coa hydrolase
NH62_21155	COG2350	Protein conserved in bacteria
NH62_21157	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NH62_21158	COG0583	DNA-binding transcription factor activity
NH62_21161	COG0612	Peptidase, M16
NH62_21162	COG5001	Diguanylate cyclase
NH62_21163	COG1032	radical SAM domain protein
NH62_21164	COG1280	lysine exporter protein (LysE YggA)
NH62_21166	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
NH62_21167	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
NH62_21168	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
NH62_21169	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NH62_21170	COG1434	Gram-negative-bacterium-type cell wall biogenesis
NH62_21171	COG0745	RESPONSE REGULATOR receiver
NH62_21172	COG3381	protein complex oligomerization
NH62_21173	COG1609	Transcriptional regulator
NH62_21174	COG3070	regulator of competence-specific genes
NH62_21178	COG0297	glycogen (starch) synthase activity
NH62_21179	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NH62_21180	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NH62_21182	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NH62_21183	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NH62_21184	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
NH62_21185	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NH62_21186	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NH62_21187	COG1960	acyl-CoA dehydrogenase activity
NH62_21191	COG1012	belongs to the aldehyde dehydrogenase family
NH62_21192	COG1309	transcriptional regulator
NH62_21196	COG0668	transmembrane transport
NH62_21197	COG2995	paraquat-inducible protein a
NH62_21198	COG3008	intermembrane lipid transfer
NH62_21198	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NH62_21200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NH62_21203	COG0582	viral genome integration into host DNA
NH62_21204	COG0582	viral genome integration into host DNA
NH62_21205	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NH62_21211	COG0415	Belongs to the DNA photolyase family
NH62_21213	COG4628	conserved protein (DUF2132)
NH62_21214	COG3284	Transcriptional regulator
NH62_21215	COG1012	belongs to the aldehyde dehydrogenase family
NH62_21217	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NH62_21218	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NH62_21219	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NH62_21221	COG2207	Transcriptional regulator
NH62_21222	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NH62_21222	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NH62_21222	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NH62_21223	COG1482	cell wall glycoprotein biosynthetic process
NH62_21225	COG5002	protein histidine kinase activity
NH62_21225	COG0784	Response regulator, receiver
NH62_21227	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NH62_21229	COG2885	chlorophyll binding
NH62_21230	COG0823	Involved in the tonB-independent uptake of proteins
NH62_21233	COG0811	peptide transport
NH62_21234	COG0824	Thioesterase
NH62_21235	COG3790	cyd operon protein YbgE
NH62_21236	COG4890	Cyd operon protein YbgT
NH62_21237	COG1294	oxidase, subunit
NH62_21238	COG1271	oxidase subunit
NH62_21240	COG2255	four-way junction helicase activity
NH62_21241	COG0632	four-way junction helicase activity
NH62_21242	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NH62_21243	COG0215	cysteine-tRNA ligase activity
NH62_21244	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NH62_21245	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NH62_21246	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NH62_21248	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
NH62_21249	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
NH62_21250	COG1199	ATP-dependent helicase activity
NH62_21251	COG0730	response to heat
NH62_21252	COG3923	Primosomal replication protein n
NH62_21254	COG0840	transmembrane signaling receptor activity
NH62_21255	COG0708	Exodeoxyribonuclease III
NH62_21256	COG4160	amino acid transport
NH62_21257	COG4215	(ABC) transporter
NH62_21262	COG1882	Formate acetyltransferase
NH62_21264	COG0840	transmembrane signaling receptor activity
NH62_21265	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NH62_21267	COG3013	Belongs to the UPF0304 family
NH62_21268	COG2766	serine protein kinase
NH62_21269	COG2718	Belongs to the UPF0229 family
NH62_21270	COG2719	SpoVR family
NH62_21271	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
NH62_21273	COG1663	tetraacyldisaccharide 4'-kinase activity
NH62_21274	COG1132	(ABC) transporter
NH62_21275	COG2333	competence protein COMEC
NH62_21275	COG0658	competence protein
NH62_21277	COG4591	ABC-type transport system involved in lipoprotein release permease component
NH62_21278	COG1136	(ABC) transporter
NH62_21279	COG4591	ABC-type transport system involved in lipoprotein release permease component
NH62_21281	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NH62_21285	COG1252	NADH dehydrogenase
NH62_21291	COG0537	adenosine 5'-monophosphoramidase activity
NH62_21295	COG2186	Transcriptional regulator
NH62_21296	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NH62_21297	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NH62_21298	COG1674	ftsk spoiiie
NH62_21300	COG0686	Belongs to the AlaDH PNT family
NH62_21302	COG0583	DNA-binding transcription factor activity
NH62_21305	COG0284	orotidine-5'-phosphate decarboxylase activity
NH62_21306	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
NH62_21307	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
NH62_21308	COG0776	regulation of translation
NH62_21309	COG0539	negative regulation of cytoplasmic translation
NH62_21310	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NH62_21311	COG1555	photosystem II stabilization
NH62_21312	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NH62_21313	COG0776	regulation of translation
NH62_21314	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NH62_21315	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NH62_21317	COG0544	peptidyl-prolyl cis-trans isomerase activity
NH62_21318	COG0544	peptidyl-prolyl cis-trans isomerase activity
NH62_21319	COG4191	Histidine kinase
NH62_21321	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NH62_21322	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
NH62_21323	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NH62_21324	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NH62_21327	COG3300	MHYT domain
NH62_21327	COG5001	Diguanylate cyclase
NH62_21329	COG4589	Belongs to the CDS family
NH62_21336	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NH62_21338	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NH62_21341	COG0243	molybdopterin cofactor binding
NH62_21342	COG3005	denitrification pathway
NH62_21343	COG3325	Belongs to the glycosyl hydrolase 18 family
NH62_21343	COG3469	chitinase activity
NH62_21344	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NH62_21346	COG2951	lytic endotransglycosylase activity
NH62_21347	COG3100	YcgL domain-containing protein
NH62_21348	COG0850	regulation of cytokinetic process
NH62_21349	COG2894	cell division
NH62_21350	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
NH62_21351	COG3015	lipoprotein NlpE involved in copper resistance
NH62_21357	COG0477	Major facilitator Superfamily
NH62_21358	COG0840	transmembrane signaling receptor activity
NH62_21359	COG1396	sequence-specific DNA binding
NH62_21360	COG3135	benzoate transporter
NH62_21362	COG1441	menaquinone biosynthetic process
NH62_21364	COG0596	Alpha beta hydrolase
NH62_21365	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NH62_21366	COG1169	isochorismate synthase
NH62_21367	COG0436	Aminotransferase
NH62_21368	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
NH62_21369	COG0232	Belongs to the dGTPase family. Type 2 subfamily
NH62_21373	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
NH62_21374	COG0318	PFAM AMP-dependent synthetase and ligase
NH62_21375	COG0596	Alpha beta hydrolase
NH62_21378	COG1214	PFAM Peptidase M22, glycoprotease
NH62_21379	COG1199	ATP-dependent helicase activity
NH62_21381	COG0788	formyltetrahydrofolate deformylase activity
NH62_21382	COG1902	pentaerythritol trinitrate reductase activity
NH62_21382	COG0446	pyridine nucleotide-disulphide oxidoreductase
NH62_21383	COG0616	signal peptide processing
NH62_21384	COG0252	asparaginase activity
NH62_21385	COG3139	Protein of unknown function (DUF1315)
NH62_21387	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NH62_21388	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NH62_21389	COG0676	glucose-6-phosphate 1-epimerase activity
NH62_21391	COG2226	methyltransferase
NH62_21394	COG0835	chemotaxis
NH62_21394	COG0784	Response regulator, receiver
NH62_21395	COG1940	carbohydrate kinase activity
NH62_21397	COG4667	esterase of the alpha-beta hydrolase superfamily
NH62_21400	COG0733	neurotransmitter:sodium symporter activity
NH62_21402	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NH62_21402	COG1263	PTS System
NH62_21403	COG0084	hydrolase, TatD family'
NH62_21405	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NH62_21406	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NH62_21407	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NH62_21408	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NH62_21409	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NH62_21410	COG1028	Short-chain dehydrogenase reductase Sdr
NH62_21411	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NH62_21412	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NH62_21413	COG0416	fatty acid biosynthetic process
NH62_21414	COG0416	fatty acid biosynthetic process
NH62_21415	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NH62_21416	COG1399	metal-binding, possibly nucleic acid-binding protein
NH62_21417	COG0424	maF-like protein
NH62_21418	COG0564	pseudouridine synthase activity
NH62_21419	COG1530	ribonuclease E activity
NH62_21420	COG0659	secondary active sulfate transmembrane transporter activity
NH62_21422	COG1012	belongs to the aldehyde dehydrogenase family
NH62_21422	COG1454	alcohol dehydrogenase
NH62_21423	COG2095	MarC family integral membrane protein
NH62_21424	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NH62_21425	COG1757	Na H antiporter
NH62_21427	COG3081	Nucleoid-associated protein
NH62_21429	COG3083	sulfuric ester hydrolase activity
NH62_21444	COG4974	Belongs to the 'phage' integrase family
NH62_21446	COG3617	BRO family, N-terminal domain
NH62_21472	COG3039	Transposase
NH62_21480	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NH62_21485	COG0123	including yeast histone deacetylase and acetoin utilization protein
NH62_21486	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NH62_21487	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NH62_21491	COG2853	Lipoprotein
NH62_21493	COG4235	cytochrome complex assembly
NH62_21493	COG3088	subunit of a heme lyase
NH62_21494	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NH62_21495	COG1138	Cytochrome C-type biogenesis protein
NH62_21496	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
NH62_21498	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NH62_21499	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NH62_21500	COG4133	protoheme IX ABC transporter activity
NH62_21502	COG0835	chemotaxis
NH62_21504	COG1192	Involved in chromosome partitioning
NH62_21505	COG2201	protein-glutamate methylesterase activity
NH62_21506	COG0643	Histidine kinase
NH62_21506	COG2198	Histidine kinase
NH62_21507	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
NH62_21510	COG0455	bacterial-type flagellum organization
NH62_21513	COG2062	phosphohistidine phosphatase, SixA
NH62_21514	COG1025	Belongs to the peptidase M16 family
NH62_21516	COG0018	arginyl-trna synthetase
NH62_21520	COG1918	ferrous iron import across plasma membrane
NH62_21521	COG4977	sequence-specific DNA binding
NH62_21522	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
NH62_21523	COG1121	(ABC) transporter
NH62_21524	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NH62_21526	COG0045	succinate-CoA ligase (ADP-forming) activity
NH62_21527	COG0045	succinate-CoA ligase (ADP-forming) activity
NH62_21528	COG0508	dehydrogenase complex catalyzes the overall conversion of
NH62_21529	COG0567	Dehydrogenase, E1 component
NH62_21531	COG1053	succinate dehydrogenase
NH62_21532	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
NH62_21533	COG2009	succinate dehydrogenase
NH62_21534	COG0372	Belongs to the citrate synthase family
NH62_21535	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NH62_21537	COG0033	Phosphoglucomutase
NH62_21538	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
NH62_21539	COG0596	Alpha beta hydrolase
NH62_21542	COG1346	cytolysis
NH62_21544	COG0583	DNA-binding transcription factor activity
NH62_21545	COG0583	DNA-binding transcription factor activity
NH62_21547	COG0735	belongs to the Fur family
NH62_21548	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NH62_21549	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NH62_21550	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NH62_21551	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NH62_21551	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
NH62_21552	COG0431	NADPH-dependent FMN reductase
NH62_21554	COG3101	peptidyl-lysine hydroxylation
NH62_21555	COG2860	membrane
NH62_21556	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NH62_21557	COG2890	protein-(glutamine-N5) methyltransferase activity
NH62_21559	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NH62_21560	COG1684	flagellar biosynthetic protein fliR
NH62_21561	COG1987	bacterial-type flagellum assembly
NH62_21566	COG1580	Controls the rotational direction of flagella during chemotaxis
NH62_21570	COG1317	bacterial-type flagellum organization
NH62_21571	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NH62_21573	COG1677	Flagellar hook-basal body complex protein FliE
NH62_21574	COG2204	response regulator
NH62_21575	COG4191	Histidine kinase
NH62_21576	COG2204	response regulator
NH62_21577	COG1516	flagellar protein fliS
NH62_21579	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
NH62_21580	COG1334	flagellar protein FlaG
NH62_21581	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NH62_21582	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NH62_21583	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NH62_21584	COG2837	iron assimilation
NH62_21588	COG1393	Belongs to the ArsC family
NH62_21589	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NH62_21590	COG1876	peptidase activity
NH62_21592	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
NH62_21593	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NH62_21595	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NH62_21599	COG4783	chaperone-mediated protein folding
NH62_21600	COG1393	Belongs to the ArsC family
NH62_21604	COG2233	PERMEase
NH62_21605	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NH62_21606	COG0737	Belongs to the 5'-nucleotidase family
NH62_21607	COG2877	3-deoxy-8-phosphooctulonate synthase activity
NH62_21608	COG2912	Transglutaminase-like superfamily
NH62_21609	COG3094	Invasion gene expression up-regulator, SirB
NH62_21610	COG2890	protein-(glutamine-N5) methyltransferase activity
NH62_21611	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NH62_21612	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NH62_21613	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
NH62_21614	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NH62_21615	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NH62_21616	COG0193	aminoacyl-tRNA hydrolase activity
NH62_21617	COG0012	GTP binding
NH62_21634	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NH62_21635	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NH62_21638	COG3951	Flagellar rod assembly protein muramidase FlgJ
NH62_21638	COG1705	Flagellar rod assembly protein muramidase FlgJ
NH62_21639	COG1706	bacterial-type flagellum-dependent cell motility
NH62_21640	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
NH62_21641	COG4786	Flagellar basal body rod
NH62_21642	COG4787	bacterial-type flagellum-dependent cell motility
NH62_21643	COG1749	Flagellar hook protein flgE
NH62_21644	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
NH62_21645	COG1558	bacterial-type flagellum-dependent cell motility
NH62_21646	COG1815	bacterial-type flagellum-dependent cell motility
NH62_21647	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NH62_21648	COG0784	Response regulator, receiver
NH62_21648	COG0835	chemotaxis
NH62_21655	COG2226	methyltransferase
NH62_21655	COG3433	isochorismatase activity
NH62_21655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NH62_21656	COG2375	cellular response to nickel ion
NH62_21657	COG1629	transport
NH62_21657	COG4774	siderophore transport
NH62_21660	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NH62_21661	COG2608	mercury ion transmembrane transporter activity
NH62_21661	COG2217	Heavy metal translocating P-type atpase
NH62_21664	COG3735	TraB family
NH62_21667	COG2840	Smr protein MutS2
NH62_21668	COG1187	pseudouridine synthase activity
NH62_21669	COG3706	GGDEF domain
NH62_21671	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NH62_21672	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NH62_21673	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NH62_21674	COG0121	glutamine amidotransferase
NH62_21675	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NH62_21676	COG1960	acyl-CoA dehydrogenase activity
NH62_21678	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NH62_21679	COG0328	RNA-DNA hybrid ribonuclease activity
NH62_21680	COG2226	methyltransferase
NH62_21681	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NH62_21682	COG1388	LysM domain
NH62_21682	COG0741	lytic transglycosylase activity
NH62_21683	COG1388	LysM domain
NH62_21683	COG3942	CHAP domain
NH62_21685	COG0347	Belongs to the P(II) protein family
NH62_21686	COG3479	Phenolic acid decarboxylase
NH62_21688	COG0037	tRNA processing
NH62_21689	COG0825	malonyl-CoA metabolic process
NH62_21690	COG0587	DNA-directed DNA polymerase activity
NH62_21691	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NH62_21692	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NH62_21693	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NH62_21694	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NH62_21695	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NH62_21696	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
NH62_21698	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NH62_21699	COG0750	zinc metalloprotease
NH62_21700	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NH62_21701	COG0575	Belongs to the CDS family
NH62_21702	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NH62_21703	COG0233	cytoplasmic translational termination
NH62_21704	COG0528	UMP kinase activity
NH62_21705	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NH62_21706	COG0052	Belongs to the universal ribosomal protein uS2 family
NH62_21707	COG0024	Methionine aminopeptidase
NH62_21708	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NH62_21710	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NH62_21711	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NH62_21712	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NH62_21713	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NH62_21716	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NH62_21716	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NH62_21717	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NH62_21718	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NH62_21719	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NH62_21722	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
NH62_21723	COG2252	PERMEase
NH62_21724	COG2195	Cleaves the N-terminal amino acid of tripeptides
NH62_21725	COG0189	ligase activity
NH62_21725	COG4067	protein conserved in archaea
NH62_21726	COG0189	ligase activity
NH62_21729	COG0733	neurotransmitter:sodium symporter activity
NH62_21730	COG3706	GGDEF domain
NH62_21732	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NH62_21734	COG1477	protein flavinylation
NH62_21735	COG2871	sodium ion transport
NH62_21736	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NH62_21737	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NH62_21738	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NH62_21739	COG1805	sodium ion transport
NH62_21740	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NH62_21741	COG0271	Belongs to the BolA IbaG family
NH62_21742	COG2813	Specifically methylates the guanine in position
NH62_21744	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NH62_21745	COG2211	Major facilitator Superfamily
NH62_21747	COG1595	DNA-templated transcription, initiation
NH62_21749	COG3248	Nucleoside-binding outer membrane protein
NH62_21750	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NH62_21751	COG0693	protein deglycase activity
NH62_21752	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NH62_21753	COG2166	iron-sulfur cluster assembly
NH62_21754	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NH62_21755	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
NH62_21757	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NH62_21757	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NH62_21759	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NH62_21760	COG1074	ATP-dependent DNA helicase activity
NH62_21761	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
NH62_21764	COG3141	response to X-ray
NH62_21765	COG2171	N-acyltransferase activity
NH62_21767	COG0456	acetyltransferase
NH62_21768	COG0189	ligase activity
NH62_21768	COG0569	domain protein
NH62_21771	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NH62_21772	COG1609	Transcriptional regulator
NH62_21773	COG3250	beta-galactosidase activity
NH62_21776	COG1022	Amp-dependent synthetase and ligase
NH62_21777	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NH62_21778	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NH62_21780	COG0560	Phosphoserine phosphatase
NH62_21781	COG0560	Phosphoserine phosphatase
NH62_21783	COG0813	purine-nucleoside phosphorylase activity
NH62_21784	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
NH62_21785	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NH62_21786	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NH62_21787	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NH62_21788	COG0084	hydrolase, TatD family'
NH62_21791	COG1115	amino acid carrier protein
NH62_21794	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NH62_21795	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NH62_21796	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
NH62_21797	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NH62_21798	COG0083	homoserine kinase activity
NH62_21801	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NH62_21803	COG0745	RESPONSE REGULATOR receiver
NH62_21804	COG5002	protein histidine kinase activity
NH62_21804	COG0784	Response regulator, receiver
NH62_21804	COG2198	Histidine kinase
NH62_21805	COG2203	Gaf domain
NH62_21805	COG5001	Diguanylate cyclase
NH62_21805	COG4251	negative regulation of phosphorylation
NH62_21805	COG3706	GGDEF domain
NH62_21806	COG1242	4 iron, 4 sulfur cluster binding
NH62_21807	COG0069	glutamate synthase activity
NH62_21807	COG0070	glutamate synthase
NH62_21807	COG0067	glutamate synthase
NH62_21809	COG0070	glutamate synthase
NH62_21809	COG0067	glutamate synthase
NH62_21809	COG0069	glutamate synthase activity
NH62_21810	COG0493	'glutamate synthase
NH62_21812	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NH62_21814	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NH62_21815	COG2860	membrane
NH62_21816	COG0583	DNA-binding transcription factor activity
NH62_21817	COG0730	response to heat
NH62_21819	COG4172	Belongs to the ABC transporter superfamily
NH62_21823	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NH62_21824	COG0505	Belongs to the CarA family
NH62_21825	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NH62_21826	COG0494	nUDIX hydrolase
NH62_21827	COG0653	protein targeting
NH62_21829	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
NH62_21830	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NH62_21831	COG0849	cell division
NH62_21832	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NH62_21833	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NH62_21834	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NH62_21835	COG0772	Belongs to the SEDS family
NH62_21836	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NH62_21837	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NH62_21838	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NH62_21839	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NH62_21840	COG0768	penicillin binding
NH62_21841	COG3116	cell division
NH62_21842	COG0275	rRNA processing
NH62_21843	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NH62_21844	COG0508	dehydrogenase complex catalyzes the overall conversion of
NH62_21845	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NH62_21846	COG2186	Transcriptional regulator
NH62_21847	COG0737	Belongs to the 5'-nucleotidase family
NH62_21848	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NH62_21849	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NH62_21850	COG4974	Belongs to the 'phage' integrase family
NH62_21851	COG0716	FMN binding
NH62_21855	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NH62_21856	COG1459	type II secretion system
NH62_21858	COG0237	dephospho-CoA kinase activity
NH62_21859	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
NH62_21860	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
NH62_21861	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NH62_21862	COG0187	DNA topoisomerase II activity
NH62_21863	COG3150	esterase
NH62_21865	COG3151	Protein conserved in bacteria
NH62_21866	COG0494	nUDIX hydrolase
NH62_21867	COG1538	Outer membrane efflux protein
NH62_21868	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NH62_21868	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NH62_21869	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NH62_21870	COG0840	transmembrane signaling receptor activity
NH62_21872	COG3025	triphosphatase activity
NH62_21873	COG1392	Phosphate transport regulator
NH62_21874	COG0306	phosphate transporter
NH62_21875	COG4991	sh3 domain protein
NH62_21877	COG3409	Peptidoglycan-binding domain 1 protein
NH62_21877	COG3267	Type II secretory pathway component ExeA
NH62_21878	COG0617	tRNA 3'-terminal CCA addition
NH62_21879	COG0148	phosphopyruvate hydratase activity
NH62_21880	COG0504	CTP synthase activity
NH62_21881	COG3956	TIGRFAM MazG family protein
NH62_21882	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NH62_21883	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NH62_21888	COG0736	holo-[acyl-carrier-protein] synthase activity
NH62_21889	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NH62_21890	COG1381	Involved in DNA repair and RecF pathway recombination
NH62_21891	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NH62_21892	COG0571	ribonuclease III activity
NH62_21893	COG0681	Belongs to the peptidase S26 family
NH62_21894	COG0481	GTPase activity
NH62_21895	COG3086	response to oxidative stress
NH62_21896	COG3026	antisigma factor binding
NH62_21898	COG1595	DNA-templated transcription, initiation
NH62_21899	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NH62_21901	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
NH62_21902	COG0354	folic acid binding
NH62_21904	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NH62_21905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NH62_21907	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
NH62_21908	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NH62_21909	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NH62_21910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NH62_21911	COG0440	acetolactate synthase activity
NH62_21912	COG0028	Belongs to the TPP enzyme family
NH62_21913	COG1022	Amp-dependent synthetase and ligase
NH62_21914	COG0583	DNA-binding transcription factor activity
NH62_21918	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NH62_21919	COG0473	3-isopropylmalate dehydrogenase activity
NH62_21920	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NH62_21921	COG0066	3-isopropylmalate dehydratase activity
NH62_21930	COG3437	response regulator, receiver
NH62_21933	COG0795	lipopolysaccharide-transporting ATPase activity
NH62_21934	COG0795	lipopolysaccharide-transporting ATPase activity
NH62_21935	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NH62_21936	COG2927	DNA polymerase III (CHI subunit)
NH62_21937	COG0525	valine-tRNA ligase activity
NH62_21938	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NH62_21939	COG0564	pseudouridine synthase activity
NH62_21940	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NH62_21941	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NH62_21942	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NH62_21943	COG0540	Belongs to the ATCase OTCase family
NH62_21944	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
NH62_21945	COG0251	oxidation-reduction process
NH62_21946	COG0204	Acyl-transferase
NH62_21947	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NH62_21948	COG5007	Belongs to the BolA IbaG family
NH62_21950	COG2854	intermembrane phospholipid transfer
NH62_21951	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NH62_21952	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NH62_21953	COG1127	ABC transporter
NH62_21955	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NH62_21955	COG0517	IMP dehydrogenase activity
NH62_21958	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
NH62_21959	COG1137	ATPase activity
NH62_21961	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NH62_21962	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NH62_21964	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NH62_21965	COG2239	Acts as a magnesium transporter
NH62_21966	COG0312	modulator of DNA gyrase
NH62_21967	COG3028	Belongs to the UPF0307 family
NH62_21968	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
NH62_21969	COG1178	ABC-type Fe3 transport system permease component
NH62_21970	COG4143	(ABC) transporter
NH62_21971	COG0163	prenyltransferase activity
NH62_21972	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NH62_21973	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
NH62_21974	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NH62_21975	COG2105	PFAM AIG2 family protein
NH62_21977	COG0729	surface antigen
NH62_21978	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NH62_21979	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
NH62_21982	COG1136	(ABC) transporter
NH62_21986	COG0529	Catalyzes the synthesis of activated sulfate
NH62_21987	COG2895	sulfate adenylyltransferase (ATP) activity
NH62_21988	COG0175	sulfate reduction
NH62_21989	COG1648	precorrin-2 dehydrogenase activity
NH62_21989	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NH62_21990	COG0737	Belongs to the 5'-nucleotidase family
NH62_21992	COG0513	Belongs to the DEAD box helicase family
NH62_21993	COG2153	protein acetylation
NH62_21994	COG0697	spore germination
NH62_21995	COG3061	Opacity-associated protein A
NH62_21995	COG3266	domain, Protein
NH62_21996	COG0545	Peptidyl-prolyl cis-trans isomerase
NH62_21997	COG1943	Transposase
NH62_21999	COG0203	ribosomal protein L17
NH62_22000	COG0202	RNA polymerase activity
NH62_22001	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NH62_22002	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NH62_22003	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NH62_22005	COG0201	protein transport
NH62_22006	COG0200	Binds to the 23S rRNA
NH62_22007	COG1841	ribosomal large subunit assembly
NH62_22008	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NH62_22009	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NH62_22010	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NH62_22011	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NH62_22012	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NH62_22013	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NH62_22014	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NH62_22015	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NH62_22016	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NH62_22017	COG0255	Belongs to the universal ribosomal protein uL29 family
NH62_22018	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NH62_22019	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NH62_22020	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NH62_22021	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NH62_22022	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NH62_22023	COG0089	rRNA binding
NH62_22024	COG0088	Forms part of the polypeptide exit tunnel
NH62_22025	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NH62_22026	COG0051	transcription antitermination factor activity, RNA binding
NH62_22027	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NH62_22028	COG0557	exoribonuclease II activity
NH62_22029	COG3083	sulfuric ester hydrolase activity
NH62_22030	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
NH62_22031	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NH62_22033	COG1047	Peptidyl-prolyl cis-trans
NH62_22036	COG2249	NAD(P)H dehydrogenase (quinone) activity
NH62_22037	COG0488	(ABC) transporter
NH62_22039	COG0429	hydrolase of the alpha beta-hydrolase fold
NH62_22041	COG3954	Phosphoribulokinase
NH62_22042	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NH62_22044	COG1012	belongs to the aldehyde dehydrogenase family
NH62_22046	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NH62_22048	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NH62_22051	COG0180	Tryptophanyl-tRNA synthetase
NH62_22052	COG0546	phosphoglycolate phosphatase activity
NH62_22053	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NH62_22054	COG0338	D12 class N6 adenine-specific DNA methyltransferase
NH62_22056	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NH62_22057	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NH62_22063	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NH62_22065	COG0678	peroxiredoxin activity
NH62_22065	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NH62_22066	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NH62_22068	COG0165	Argininosuccinate lyase
NH62_22069	COG0137	argininosuccinate synthase activity
NH62_22070	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NH62_22071	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NH62_22072	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NH62_22073	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NH62_22075	COG1045	serine acetyltransferase
NH62_22076	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NH62_22077	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
NH62_22078	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NH62_22079	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
NH62_22080	COG1053	succinate dehydrogenase
NH62_22081	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NH62_22082	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
NH62_22083	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
NH62_22084	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NH62_22085	COG1509	lysine 2,3-aminomutase activity
NH62_22087	COG0459	protein refolding
NH62_22088	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NH62_22093	COG0149	triose-phosphate isomerase activity
NH62_22095	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NH62_22096	COG1575	Belongs to the MenA family. Type 1 subfamily
NH62_22097	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NH62_22098	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NH62_22099	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NH62_22100	COG1609	Transcriptional regulator
NH62_22101	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NH62_22102	COG0254	rRNA binding
NH62_22103	COG0281	malic enzyme
NH62_22104	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
NH62_22105	COG0626	cystathionine gamma-synthase activity
NH62_22106	COG0527	aspartate kinase activity
NH62_22106	COG0460	homoserine dehydrogenase
NH62_22107	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NH62_22108	COG3074	FtsZ-dependent cytokinesis
NH62_22109	COG1494	fructose-1,6-bisphosphatase
NH62_22110	COG0205	6-phosphofructokinase activity
NH62_22111	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NH62_22113	COG0745	RESPONSE REGULATOR receiver
NH62_22114	COG2205	protein histidine kinase activity
NH62_22116	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NH62_22117	COG3030	protein affecting phage T7 exclusion by the F plasmid
NH62_22118	COG3706	GGDEF domain
NH62_22119	COG1027	Aspartate ammonia-lyase
NH62_22120	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
NH62_22122	COG4232	protein-disulfide reductase activity
NH62_22124	COG3263	regulation of cellular component size
NH62_22126	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NH62_22127	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NH62_22128	COG0194	GDP metabolic process
NH62_22129	COG1758	RNA polymerase activity
NH62_22130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NH62_22131	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NH62_22132	COG2233	PERMEase
NH62_22134	COG0745	RESPONSE REGULATOR receiver
NH62_22135	COG2199	diguanylate cyclase activity
NH62_22136	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NH62_22137	COG2183	response to ionizing radiation
NH62_22139	COG0596	Alpha beta hydrolase
NH62_22140	COG1040	competence protein
NH62_22141	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NH62_22141	COG0316	Belongs to the HesB IscA family
NH62_22142	COG0494	nUDIX hydrolase
NH62_22143	COG1218	3'(2'),5'-bisphosphate nucleotidase
NH62_22145	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
NH62_22146	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
NH62_22147	COG3156	type II secretion system protein K
NH62_22148	COG4795	General secretion pathway protein
NH62_22149	COG2165	general secretion pathway protein
NH62_22150	COG2165	general secretion pathway protein
NH62_22151	COG2165	general secretion pathway protein
NH62_22152	COG1459	type II secretion system
NH62_22153	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NH62_22155	COG3031	protein transport across the cell outer membrane
NH62_22156	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NH62_22157	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NH62_22158	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NH62_22160	COG0456	acetyltransferase
NH62_22161	COG1490	D-aminoacyl-tRNA deacylase activity
NH62_22166	COG0174	glutamine synthetase
NH62_22168	COG3852	Histidine kinase
NH62_22170	COG3300	MHYT domain
NH62_22170	COG5001	Diguanylate cyclase
NH62_22171	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NH62_22185	COG0175	sulfate reduction
NH62_22186	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NH62_22187	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NH62_22191	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NH62_22192	COG0735	belongs to the Fur family
NH62_22195	COG0166	Belongs to the GPI family
NH62_22196	COG0432	Pfam Uncharacterised protein family UPF0047
NH62_22197	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NH62_22198	COG0305	Participates in initiation and elongation during chromosome replication
NH62_22200	COG0359	binds to the 23S rRNA
NH62_22201	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NH62_22202	COG2965	DNA replication, synthesis of RNA primer
NH62_22203	COG0360	Binds together with S18 to 16S ribosomal RNA
NH62_22205	COG2906	2 iron, 2 sulfur cluster binding
NH62_22206	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NH62_22207	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NH62_22208	COG0049	tRNA binding
NH62_22209	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NH62_22211	COG2923	Belongs to the DsrF TusC family
NH62_22212	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
NH62_22213	COG2964	Protein conserved in bacteria
NH62_22214	COG0545	Peptidyl-prolyl cis-trans isomerase
NH62_22216	COG2900	Belongs to the SlyX family
NH62_22217	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
NH62_22218	COG0330	HflC and HflK could
NH62_22219	COG0330	HflC and HflK could
NH62_22220	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NH62_22221	COG1923	regulation of RNA biosynthetic process
NH62_22222	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NH62_22223	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NH62_22225	COG0802	atpase or kinase
NH62_22226	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NH62_22236	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NH62_22237	COG1162	GTPase activity
NH62_22238	COG0688	phosphatidylethanolamine metabolic process
NH62_22239	COG0471	metal ion transport
NH62_22241	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NH62_22242	COG4942	peptidase
NH62_22245	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NH62_22246	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NH62_22247	COG2816	NAD+ diphosphatase activity
NH62_22248	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
NH62_22249	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NH62_22250	COG0085	RNA polymerase activity
NH62_22251	COG0222	ribosome binding
NH62_22252	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NH62_22253	COG0081	regulation of translation
NH62_22254	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NH62_22255	COG0250	Participates in transcription elongation, termination and antitermination
NH62_22256	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NH62_22257	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NH62_22262	COG1072	(Pantothenic acid kinase))
NH62_22264	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NH62_22266	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NH62_22275	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NH62_22277	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NH62_22278	COG3118	belongs to the thioredoxin family
NH62_22279	COG0513	Belongs to the DEAD box helicase family
NH62_22280	COG0248	Ppx GppA phosphatase
NH62_22281	COG2205	protein histidine kinase activity
NH62_22281	COG0784	Response regulator, receiver
NH62_22282	COG2814	Major facilitator Superfamily
NH62_22285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NH62_22286	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NH62_22287	COG0511	ligase activity, forming carbon-carbon bonds
NH62_22288	COG0439	Biotin carboxylase
NH62_22289	COG2264	protein methyltransferase activity
NH62_22290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NH62_22291	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
NH62_22293	COG1609	Transcriptional regulator
NH62_22294	COG0129	dihydroxy-acid dehydratase activity
NH62_22295	COG3265	gluconokinase activity
NH62_22297	COG0800	Aldolase
NH62_22300	COG0840	transmembrane signaling receptor activity
NH62_22301	COG1982	Orn Lys Arg decarboxylase major
NH62_22302	COG0531	amino acid
NH62_22303	COG3710	Transcriptional regulator
NH62_22304	COG0789	Transcriptional regulator
NH62_22305	COG0138	bifunctional purine biosynthesis protein purh
NH62_22306	COG0151	Belongs to the GarS family
NH62_22308	COG0776	regulation of translation
NH62_22309	COG1253	flavin adenine dinucleotide binding
NH62_22310	COG1940	carbohydrate kinase activity
NH62_22312	COG3068	Protein conserved in bacteria
NH62_22314	COG1573	uracil-dna glycosylase
NH62_22315	COG0668	transmembrane transport
NH62_22316	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NH62_22322	COG5433	transposase activity
NH62_22323	COG5433	transposase activity
NH62_22326	COG1012	belongs to the aldehyde dehydrogenase family
NH62_22326	COG1454	alcohol dehydrogenase
NH62_22327	COG0318	PFAM AMP-dependent synthetase and ligase
NH62_22333	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
NH62_22334	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NH62_22335	COG0662	Cupin 2, conserved barrel domain protein
NH62_22335	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
NH62_22336	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NH62_22343	COG1519	Transferase
NH62_22350	COG3642	lipopolysaccharide core region biosynthetic process
NH62_22351	COG0859	PFAM glycosyl transferase family 9
NH62_22352	COG0463	Glycosyl transferase, family 2
NH62_22353	COG0859	PFAM glycosyl transferase family 9
NH62_22354	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NH62_22355	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NH62_22357	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NH62_22358	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NH62_22370	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NH62_22371	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NH62_22380	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NH62_22381	COG1309	transcriptional regulator
NH62_22382	COG1560	Kdo2-lipid A biosynthetic process
NH62_22383	COG1560	Kdo2-lipid A biosynthetic process
NH62_22384	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NH62_22385	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NH62_22386	COG1561	YicC-like family, N-terminal region
NH62_22387	COG1561	YicC-like family, N-terminal region
NH62_22389	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
NH62_22390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NH62_22390	COG1263	PTS System
NH62_22391	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NH62_22395	COG1120	ATPase activity
NH62_22396	COG4774	siderophore transport
NH62_22397	COG1132	(ABC) transporter
NH62_22400	COG0514	ATP-dependent DNA helicase (RecQ)
NH62_22401	COG2962	Rard protein
NH62_22402	COG0405	Gamma-glutamyltransferase
NH62_22404	COG1280	lysine exporter protein (LysE YggA)
NH62_22405	COG0210	DNA helicase
NH62_22407	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NH62_22408	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NH62_22410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NH62_22412	COG0747	negative chemotaxis
NH62_22421	COG1309	transcriptional regulator
NH62_22422	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NH62_22423	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NH62_22424	COG2960	long-chain fatty acid transporting porin activity
NH62_22425	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NH62_22426	COG0583	DNA-binding transcription factor activity
NH62_22439	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
NH62_22440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NH62_22441	COG1739	Uncharacterized protein family UPF0029
NH62_22442	COG1024	Enoyl-CoA hydratase
NH62_22442	COG1250	3-hydroxyacyl-CoA dehydrogenase
NH62_22443	COG0183	Belongs to the thiolase family
NH62_22444	COG0583	DNA-binding transcription factor activity
NH62_22445	COG2814	Major facilitator Superfamily
NH62_22447	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NH62_22448	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NH62_22449	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NH62_22450	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NH62_22451	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NH62_22452	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NH62_22454	COG0356	it plays a direct role in the translocation of protons across the membrane
NH62_22455	COG3312	ion transport
NH62_22456	COG1475	DNA binding
NH62_22457	COG1192	Involved in chromosome partitioning
NH62_22458	COG0357	Ribosomal RNA small subunit methyltransferase G
NH62_22459	COG0445	tRNA wobble uridine modification
NH62_22460	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NH62_22461	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NH62_22462	COG0706	membrane insertase activity
NH62_22463	COG0594	ribonuclease P activity
NH62_22464	COG0230	Belongs to the bacterial ribosomal protein bL34 family
NH62_22465	COG1126	abc transporter atp-binding protein
NH62_22468	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NH62_22469	COG0592	DNA-directed DNA polymerase activity
NH62_22470	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NH62_22471	COG0187	DNA topoisomerase II activity
NH62_22474	COG0071	Belongs to the small heat shock protein (HSP20) family
NH62_22475	COG3977	Valine--pyruvate aminotransferase
NH62_22476	COG0751	glycine-tRNA ligase activity
NH62_22477	COG0752	glycyl-tRNA synthetase alpha subunit
NH62_22478	COG2119	membrane
NH62_22480	COG0425	Belongs to the sulfur carrier protein TusA family
NH62_22482	COG0604	alcohol dehydrogenase
NH62_22484	COG0129	dihydroxy-acid dehydratase activity
NH62_22485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NH62_22488	COG0606	chelatase, subunit chli
NH62_22489	COG0204	Acyl-transferase
NH62_22490	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NH62_22491	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NH62_22493	COG3084	Protein conserved in bacteria
NH62_22494	COG4326	sporulation control protein
NH62_22495	COG1272	protein, Hemolysin III
NH62_22497	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NH62_22498	COG0569	domain protein
NH62_22499	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NH62_22499	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NH62_22500	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NH62_22501	COG0242	peptide deformylase activity
NH62_22502	COG1652	LysM domain
NH62_22503	COG0758	DNA mediated transformation
NH62_22504	COG2922	Belongs to the Smg family
NH62_22505	COG0551	DNA topoisomerase type I activity
NH62_22506	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NH62_22507	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NH62_22508	COG0009	L-threonylcarbamoyladenylate synthase
NH62_22509	COG0408	coproporphyrinogen oxidase activity
NH62_22510	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NH62_22512	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NH62_22519	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NH62_22520	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NH62_22522	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NH62_22523	COG2104	thiamine diphosphate biosynthetic process
NH62_22524	COG2022	thiamine diphosphate biosynthetic process
NH62_22525	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NH62_22526	COG0006	proline dipeptidase activity
NH62_22526	COG0006	proline dipeptidase activity
NH62_22530	COG1522	sequence-specific DNA binding
NH62_22531	COG5002	protein histidine kinase activity
NH62_22531	COG5001	Diguanylate cyclase
NH62_22532	COG0742	ribosomal rna small subunit methyltransferase
NH62_22534	COG0697	spore germination
NH62_22535	COG0589	response to stress
NH62_22536	COG1528	Iron-storage protein
NH62_22538	COG2081	HI0933 family
NH62_22540	COG1322	Protein conserved in bacteria
NH62_22541	COG2226	methyltransferase
NH62_22543	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NH62_22544	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NH62_22545	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NH62_22546	COG0805	protein transport
NH62_22547	COG0534	Mate efflux family protein
NH62_22549	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NH62_22550	COG2937	Belongs to the GPAT DAPAT family
NH62_22551	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NH62_22552	COG3161	chorismate lyase activity
NH62_22553	COG1580	Controls the rotational direction of flagella during chemotaxis
NH62_22554	COG0840	transmembrane signaling receptor activity
NH62_22556	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NH62_22557	COG0084	hydrolase, TatD family'
NH62_22560	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NH62_22560	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NH62_22561	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NH62_22564	COG3078	GTPase activator activity
NH62_22566	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NH62_22567	COG3071	HemY protein
NH62_22568	COG2959	enzyme of heme biosynthesis
NH62_22569	COG1587	Uroporphyrinogen-III synthase
NH62_22570	COG0181	hydroxymethylbilane synthase activity
NH62_22571	COG3072	Adenylate cyclase
NH62_22572	COG1965	Belongs to the frataxin family
NH62_22573	COG1965	Belongs to the frataxin family
NH62_22574	COG0019	diaminopimelate decarboxylase activity
NH62_22575	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NH62_22577	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
NH62_22578	COG1011	Hydrolase
NH62_22579	COG3287	FIST C domain
NH62_22579	COG2200	EAL domain
NH62_22579	COG2199	diguanylate cyclase activity
NH62_22582	COG0561	phosphatase activity
NH62_22583	COG2267	carboxylic ester hydrolase activity
NH62_22584	COG1280	lysine exporter protein (LysE YggA)
NH62_22585	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NH62_22586	COG0783	Belongs to the Dps family
NH62_22591	COG0742	ribosomal rna small subunit methyltransferase
NH62_22592	COG0552	protein localization to endoplasmic reticulum
NH62_22593	COG2884	Cell division ATP-binding protein ftsE
NH62_22594	COG2177	Part of the ABC transporter FtsEX involved in
NH62_22595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NH62_22596	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NH62_22599	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NH62_22600	COG4206	TonB-dependent receptor
NH62_22601	COG1404	Belongs to the peptidase S8 family
NH62_22602	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NH62_22616	COG1410	methionine synthase
NH62_22616	COG0646	methionine synthase
NH62_22617	COG0527	aspartate kinase activity
NH62_22618	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NH62_22620	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NH62_22623	COG0629	single-stranded DNA binding
NH62_22624	COG2199	diguanylate cyclase activity
NH62_22624	COG2200	EAL domain
NH62_22629	COG3267	Type II secretory pathway component ExeA
NH62_22629	COG3409	Peptidoglycan-binding domain 1 protein
NH62_22631	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NH62_22632	COG1459	type II secretion system
NH62_22641	COG1077	Cell shape determining protein MreB Mrl
NH62_22642	COG1792	Involved in formation and maintenance of cell shape
NH62_22643	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NH62_22644	COG0424	maF-like protein
NH62_22645	COG1530	ribonuclease E activity
NH62_22646	COG3164	Protein of unknown function
NH62_22647	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NH62_22648	COG0312	modulator of DNA gyrase
NH62_22649	COG2235	arginine
NH62_22653	COG0589	response to stress
NH62_22656	COG1438	arginine binding
NH62_22657	COG0039	L-malate dehydrogenase activity
NH62_22658	COG0531	amino acid
NH62_22659	COG0142	geranyltranstransferase activity
NH62_22660	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NH62_22661	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NH62_22662	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NH62_22663	COG2966	Psort location CytoplasmicMembrane, score
NH62_22664	COG3610	response to peptide
NH62_22666	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NH62_22667	COG2967	ApaG domain
NH62_22668	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NH62_22669	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NH62_22670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NH62_22671	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
NH62_22672	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA