locus-tag class description BBB50_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BBB50_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BBB50_00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BBB50_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BBB50_00035 ENOG4108ZNX Heat shock protein BBB50_00040 ENOG4105JKW Valine--pyruvate aminotransferase BBB50_00045 ENOG4105C38 Glycyl-tRNA synthetase beta subunit BBB50_00050 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit BBB50_00065 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) BBB50_00075 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family BBB50_00080 ENOG4105C7B Threonine dehydratase BBB50_00085 ENOG4105C01 Dihydroxy-acid dehydratase BBB50_00090 ENOG4105CM2 brancheD-chain amino acid aminotransferase BBB50_00105 ENOG4105C0P Mg chelatase subunit ChlI BBB50_00110 ENOG4106HNH Acyl-transferase BBB50_00115 ENOG4108Z33 Thiol disulfide Interchange Protein BBB50_00120 ENOG4105E27 serine threonine protein kinase BBB50_00130 ENOG4105PC1 Conserved Protein BBB50_00140 ENOG4108N23 SpoOM-related protein BBB50_00145 ENOG4108UT2 hemolysin iii BBB50_00155 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) BBB50_00160 ENOG4105C1A potassium transporter peripheral membrane BBB50_00165 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BBB50_00170 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BBB50_00175 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BBB50_00180 ENOG4108WZM domain protein BBB50_00185 ENOG4105C79 DNA protecting protein DprA BBB50_00190 ENOG4108RPN Protein smg homolog BBB50_00195 ENOG4108WI1 Dna topoisomerase BBB50_00200 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BBB50_00205 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BBB50_00210 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BBB50_00215 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) BBB50_00220 ENOG4105E2X shikimate dehydrogenase BBB50_00230 ENOG4108Z0R Transferase BBB50_00275 ENOG4105WMR Protein CrcB homolog BBB50_00280 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) BBB50_00290 ENOG4105D06 uba thif-type nad fad binding protein BBB50_00295 ENOG4105WHD thiamine biosynthesis protein ThiS BBB50_00300 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) BBB50_00305 ENOG4105D41 biosynthesis protein thiH BBB50_00310 ENOG4105DC7 peptidase M24 BBB50_00310 ENOG4105DC7 peptidase M24 BBB50_00320 ENOG4105CNH Multidrug resistance protein MdtL BBB50_00330 ENOG4108VVK transcriptional Regulator, AsnC BBB50_00335 ENOG4105BZU Histidine kinase BBB50_00340 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) BBB50_00350 ENOG4105EMK carboxylate amino acid amine transporter BBB50_00355 ENOG4108M6U Universal stress protein A BBB50_00365 ENOG41090A1 ferritin BBB50_00370 ENOG4108V6B universal stress protein B BBB50_00375 ENOG4105CBX hi0933 family BBB50_00385 ENOG4105CGY Dna recombination protein BBB50_00390 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BBB50_00395 ENOG4105JC1 sterol-binding domain protein BBB50_00400 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) BBB50_00405 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BBB50_00410 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) BBB50_00415 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BBB50_00420 ENOG4105CA0 peroxidase BBB50_00425 ENOG4107R73 Mate efflux family protein BBB50_00435 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BBB50_00440 ENOG4105E55 glycerol-3-phosphate acyltransferase BBB50_00445 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) BBB50_00450 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) BBB50_00460 ENOG4105X6C Flagellar basal body-associated protein FliL BBB50_00465 ENOG4105C8Q Methyl-accepting chemotaxis BBB50_00475 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) BBB50_00485 ENOG4105F8V Hydrolase, tatD family BBB50_00490 ENOG4105D52 delta-aminolevulinic acid dehydratase BBB50_00500 ENOG4105C2M dna polymerase I BBB50_00505 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) BBB50_00510 ENOG4106RE7 Cytochrome BBB50_00520 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) BBB50_00525 ENOG4105XCT Protein of unknown function (DUF2489) BBB50_00530 ENOG4105D4P Coproporphyrinogen iii oxidase BBB50_00535 ENOG410601J HemY protein BBB50_00540 ENOG4105ECF c-methyltransferase BBB50_00545 ENOG41076E6 Uroporphyrinogen-III Synthase BBB50_00550 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BBB50_00560 ENOG4107T0K Adenylate cyclase BBB50_00565 ENOG4105XQ6 frataxin-like protein BBB50_00575 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BBB50_00580 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) BBB50_00585 ENOG4105CT0 Protein of unknown function, DUF484 BBB50_00590 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BBB50_00595 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant BBB50_00600 ENOG4105BZU Histidine kinase BBB50_00620 ENOG4105DQF Hydrolase BBB50_00625 ENOG4108EUD Lysophospholipase BBB50_00630 ENOG410829K Lysine exporter protein (Lyse ygga) BBB50_00635 ENOG4105D58 Diguanylate phosphodiesterase BBB50_00640 ENOG4108RMU ferritin dps family protein BBB50_00675 ENOG4106H78 methyltransferase BBB50_00680 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BBB50_00685 ENOG4105CAK Cell division ATP-binding protein ftsE BBB50_00690 ENOG4105CRP Part of the ABC transporter FtsEX involved in BBB50_00695 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BBB50_00700 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) BBB50_00715 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) BBB50_00720 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) BBB50_00725 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin BBB50_00730 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BBB50_00805 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) BBB50_00810 ENOG4105BZU Histidine kinase BBB50_00815 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BBB50_00820 ENOG4105CUX Signal transduction histidine kinase BBB50_00830 ENOG4105C5F glutamine synthetase BBB50_00855 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BBB50_00860 ENOG4105SUU thioesterase domain BBB50_00870 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase BBB50_00875 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) BBB50_00880 ENOG4105VEJ Heat shock protein BBB50_00885 ENOG4108XKW General secretion pathway protein C BBB50_00895 ENOG4107QHF type ii secretion system protein e BBB50_00900 ENOG4105D7Q type ii secretion system BBB50_00905 ENOG4108VAU general secretion pathway protein G BBB50_00910 ENOG4105VWV general secretion pathway protein h BBB50_00915 ENOG4105X5Z General secretion pathway protein I BBB50_00920 ENOG4108WWZ General secretion pathway protein J BBB50_00925 ENOG4108RTD type II secretion system protein K BBB50_00930 ENOG4108BY5 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) BBB50_00935 ENOG4105U1E general secretion pathway protein M BBB50_00940 ENOG4105PIC general secretion pathway protein N BBB50_00945 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase BBB50_00950 ENOG4107RK2 ADP-ribose diphosphatase NudE BBB50_00955 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) BBB50_00960 ENOG4105MJ2 Competence protein BBB50_00965 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BBB50_00975 ENOG4105BZM domain protein BBB50_00980 ENOG4108RRZ Transcription elongation factor GreB BBB50_00985 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BBB50_00990 ENOG4105E0F Histidine kinase BBB50_00995 ENOG4105C2W permease BBB50_01000 ENOG4105CB5 ATP-dependent DNA helicase recG BBB50_01005 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BBB50_01010 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) BBB50_01015 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BBB50_01020 ENOG4105EX9 Membrane BBB50_01025 ENOG4107QN1 sodium solute BBB50_01035 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) BBB50_01045 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) BBB50_01060 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BBB50_01065 ENOG4108IJ0 Aspartate ammonia-lyase BBB50_01070 ENOG4105BZU Histidine kinase BBB50_01075 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 BBB50_01080 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BBB50_01090 ENOG4105E0F Histidine kinase BBB50_01095 ENOG4105E3W Two component transcriptional regulator (Winged helix family BBB50_01105 ENOG41076HS cation diffusion facilitator family transporter BBB50_01110 ENOG4105CTQ phosphohexokinase BBB50_01115 ENOG4105CBT Fructose-1,6-bisphosphatase BBB50_01120 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) BBB50_01125 ENOG4105SYT Methylenetetrahydrofolate reductase BBB50_01130 ENOG4105CFH Aspartokinase BBB50_01135 ENOG4105C28 cystathionine BBB50_01140 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) BBB50_01145 ENOG4105C6K Malic enzyme BBB50_01150 ENOG4105VFB Binds the 23S rRNA (By similarity) BBB50_01155 ENOG4105C25 Primosomal protein n' BBB50_01160 ENOG4105ETE Transcriptional regulator (LacI family BBB50_01165 ENOG41063M6 Cell Division Protein BBB50_01170 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) BBB50_01175 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) BBB50_01180 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BBB50_01185 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) BBB50_01195 ENOG4105CP7 Triose-phosphate isomerase BBB50_01220 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BBB50_01225 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BBB50_01235 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BBB50_01240 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BBB50_01245 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) BBB50_01250 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) BBB50_01255 ENOG4105E33 succinate dehydrogenase BBB50_01265 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) BBB50_01270 ENOG4107YZP Rhodanese domain protein BBB50_01275 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) BBB50_01280 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BBB50_01285 ENOG4105D7W serine acetyltransferase BBB50_01295 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) BBB50_01300 ENOG4105CWC Acetylornithine deacetylase BBB50_01305 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BBB50_01310 ENOG4105CAS nag kinase BBB50_01315 ENOG4105CDH Citrulline--aspartate ligase BBB50_01320 ENOG4105CH7 arginosuccinase BBB50_01330 ENOG4107QN2 dihydrolipoyl dehydrogenase BBB50_01335 ENOG4105EHV domain protein BBB50_01345 ENOG4108JQC penicillin-binding protein 1A BBB50_01365 ENOG41061A0 Mu-like prophage Flumu protein BBB50_01370 ENOG4108T86 baseplate J family protein BBB50_01380 ENOG4105PZ7 Baseplate assembly protein BBB50_01415 ENOG4105TKZ Tail Sheath BBB50_01435 ENOG4105Y5J prophage protein BBB50_01445 ENOG4105EFV Major head subunit BBB50_01480 ENOG4105QIB mu-like prophage Flumu protein gp29 BBB50_01485 ENOG4105CF2 Mu-like prophage FluMu protein GP28 BBB50_01490 ENOG4108Z6H mu-like prophage Flumu protein gp27 BBB50_01555 ENOG41065S5 BBB50_01610 ENOG4108WTW DNA transposition protein BBB50_01615 ENOG4106YXT transposase BBB50_01620 ENOG4105R8V Transcriptional regulator BBB50_01650 ENOG4105E4G Type IV pilus BBB50_01655 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BBB50_01660 ENOG4105D49 3-dehydroquinate synthase BBB50_01670 ENOG4105DFE Dna adenine methylase BBB50_01675 ENOG4105DJV ribulose-phosphate 3-epimerase BBB50_01680 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BBB50_01685 ENOG4105C31 Tryptophanyl-tRNA synthetase BBB50_01700 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) BBB50_01705 ENOG4105DDQ anthranilate synthase BBB50_01710 ENOG4105C8Y Acetylornithine aminotransferase BBB50_01730 ENOG4107RYR Transcriptional regulator, Crp Fnr family BBB50_01735 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) BBB50_01745 ENOG4105DNZ Alpha Beta Hydrolase BBB50_01755 ENOG4105C5H ABC transporter BBB50_01760 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BBB50_01775 ENOG4108YZY peptidylprolyl cis-trans isomerase BBB50_01780 ENOG4105D44 asparaginase BBB50_01785 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BBB50_01790 ENOG4108UV7 flagellar protein motX BBB50_01795 ENOG4105E68 Sulfatase BBB50_01800 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BBB50_01805 ENOG4105C2N RNA methyltransferase TrmH family group 3 BBB50_01810 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) BBB50_01815 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BBB50_01820 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BBB50_01825 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BBB50_01830 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BBB50_01835 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BBB50_01840 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BBB50_01845 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BBB50_01850 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BBB50_01855 ENOG41083MP 50s ribosomal protein l29 BBB50_01860 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BBB50_01865 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) BBB50_01870 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) BBB50_01875 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits BBB50_01880 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BBB50_01885 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BBB50_01890 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BBB50_01895 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) BBB50_01900 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BBB50_01905 ENOG4105VPB 50S ribosomal protein L30 BBB50_01910 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BBB50_01915 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BBB50_01925 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits BBB50_01930 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BBB50_01935 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BBB50_01940 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BBB50_01945 ENOG4108ZT0 50S ribosomal protein l17 BBB50_01955 ENOG4108V1T peptidylprolyl cis-trans isomerase BBB50_01960 ENOG4108UBT opacity-associated protein BBB50_01965 ENOG4108SXK Transporter Drug Metabolite Exporter family BBB50_01970 ENOG4107YB6 acetyltransferase, (GNAT) family BBB50_01975 ENOG4105C1J atp-dependent rna helicase BBB50_01985 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic BBB50_01990 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BBB50_01995 ENOG4105C11 sulfate adenylyltransferase), subunit 2 BBB50_02000 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) BBB50_02005 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) BBB50_02025 ENOG4105C19 ABC transporter BBB50_02040 ENOG4108UUE Transcriptional regulator BBB50_02045 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BBB50_02050 ENOG4105CFU surface antigen BBB50_02060 ENOG41066HZ AIG2-like family BBB50_02065 ENOG4105F0N pyrophosphate phospho-hydrolase BBB50_02070 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 BBB50_02080 ENOG4105DFU Cell wall formation (By similarity) BBB50_02085 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase BBB50_02090 ENOG4105DP9 ABC transporter BBB50_02095 ENOG4106SMU thiamine transporter membrane protein BBB50_02100 ENOG4107T0D ABC, transporter BBB50_02105 ENOG4105N42 UPF0307 protein BBB50_02110 ENOG4105CMS peptidase U62, modulator of DNA gyrase BBB50_02115 ENOG4105CJW magnesium transporter BBB50_02120 ENOG41080Z8 PHOSPHOCARRIER protein BBB50_02130 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN BBB50_02135 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA BBB50_02140 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BBB50_02145 ENOG4108IUZ ABC transporter BBB50_02150 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA BBB50_02160 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase BBB50_02165 ENOG4105C2X Arabinose 5-phosphate isomerase BBB50_02180 ENOG4105DHJ ABC, transporter BBB50_02185 ENOG4105CY3 ABC transporter, permease BBB50_02190 ENOG4107PE3 Mammalian cell entry related domain protein BBB50_02195 ENOG4105E3I toluene tolerance BBB50_02205 ENOG4105VFK BolA family BBB50_02210 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BBB50_02215 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase BBB50_02220 ENOG4105KME endoribonuclease L-psp BBB50_02225 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) BBB50_02230 ENOG4105CXT aspartate transcarbamylase BBB50_02240 ENOG4105DBV ornithine carbamoyltransferase BBB50_02245 ENOG4108IAB Phoh family BBB50_02255 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) BBB50_02260 ENOG4105D3G Pseudouridine synthase BBB50_02265 ENOG4105C5I Dehydrogenase BBB50_02270 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BBB50_02275 ENOG4105MYG DNA polymerase iii, chi subunit BBB50_02280 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BBB50_02285 ENOG4108M8S permease YjgP YjgQ family protein BBB50_02290 ENOG4108K5H permease YjgP YjgQ family protein BBB50_02305 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BBB50_02350 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BBB50_02355 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BBB50_02360 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BBB50_02365 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BBB50_02385 ENOG41064T2 transcriptional regulator, lysR family BBB50_02390 ENOG4108IQE Amp-dependent synthetase and ligase BBB50_02395 ENOG4105C7K acetolactate synthase BBB50_02400 ENOG4108ZP8 Acetolactate synthase small subunit BBB50_02405 ENOG4108JQ1 Dehydrogenase BBB50_02410 ENOG4105E66 phosphoriboisomerase A BBB50_02415 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BBB50_02425 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) BBB50_02435 ENOG4105D0A hydroxylase BBB50_02440 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family BBB50_02450 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) BBB50_02455 ENOG4105Y75 tpr repeat protein BBB50_02465 ENOG4108IYU L-aspartate oxidase BBB50_02475 ENOG4105EMN RNA polymerase sigma factor BBB50_02485 ENOG4105VQK sigma E regulatory protein, MucB RseB BBB50_02490 ENOG4105WMJ Positive regulator of sigma E, RseC MucC BBB50_02495 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BBB50_02500 ENOG4105C3F Signal peptidase i BBB50_02505 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BBB50_02510 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BBB50_02515 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) BBB50_02520 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) BBB50_02525 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) BBB50_02540 ENOG4108K0B C-di-gmp phosphodiesterase BBB50_02545 ENOG4105BZU Histidine kinase BBB50_02550 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BBB50_02555 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BBB50_02560 ENOG4105DXN mazG family BBB50_02565 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BBB50_02570 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BBB50_02575 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate BBB50_02595 ENOG4105CJ3 phosphate transporter BBB50_02600 ENOG4107IX6 phosphate transport regulator BBB50_02605 ENOG4105I7R Adenylate cyclase BBB50_02610 ENOG4105C8Q Methyl-accepting chemotaxis BBB50_02615 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) BBB50_02625 ENOG4105DFG type I secretion outer membrane protein BBB50_02630 ENOG41087AY ADP-Ribose pyrophosphatase BBB50_02635 ENOG4108SX3 cytoplasmic protein BBB50_02640 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) BBB50_02645 ENOG4105IPS esterase BBB50_02650 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BBB50_02655 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BBB50_02660 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) BBB50_02665 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) BBB50_02670 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BBB50_02675 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) BBB50_02680 ENOG4105D7Q type ii secretion system BBB50_02685 ENOG4107QHF type ii secretion system protein e BBB50_02695 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BBB50_02705 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) BBB50_02710 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BBB50_02715 ENOG4105T95 Thiol disulfide interChange protein BBB50_02720 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BBB50_02725 ENOG4105CGH 5'-nucleotidase BBB50_02730 ENOG41073TP transcriptional regulator BBB50_02735 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) BBB50_02740 ENOG4107QSN dihydrolipoamide acetyltransferase BBB50_02745 ENOG4107QN2 dihydrolipoyl dehydrogenase BBB50_02755 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BBB50_02760 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) BBB50_02765 ENOG4105CJN penicillin-binding protein BBB50_02770 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BBB50_02775 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) BBB50_02780 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BBB50_02785 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BBB50_02795 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BBB50_02800 ENOG4105DFU Cell wall formation (By similarity) BBB50_02805 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) BBB50_02810 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BBB50_02815 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BBB50_02820 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BBB50_02830 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BBB50_02840 ENOG4105M6F mutator MutT protein BBB50_02845 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BBB50_02855 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BBB50_02860 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BBB50_02885 ENOG4107RRE RNA-directed DNA polymerase BBB50_02890 ENOG4105EJ9 Membrane BBB50_02895 ENOG4105VP0 transcriptional regulator, lysR family BBB50_02900 ENOG4105EN6 Membrane BBB50_02905 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) BBB50_02915 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BBB50_02925 ENOG4105BZ8 glutamate synthase BBB50_02930 ENOG4105CBC glutamate synthase BBB50_02945 ENOG4105N5T Radical SAM Protein BBB50_02955 ENOG4105BZU Histidine kinase BBB50_02960 ENOG41065U4 response regulator BBB50_02970 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) BBB50_02985 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BBB50_02990 ENOG4105D98 threonine synthase BBB50_02995 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) BBB50_03000 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) BBB50_03005 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BBB50_03020 ENOG4105BZG amino acid carrier protein BBB50_03030 ENOG4105EYA deoxyribonuclease BBB50_03035 ENOG4105D9N nucleoside BBB50_03045 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) BBB50_03050 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BBB50_03055 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) BBB50_03060 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BBB50_03070 ENOG4105EAC phosphoserine phosphatase BBB50_03080 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BBB50_03085 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BBB50_03090 ENOG4108IQE Amp-dependent synthetase and ligase BBB50_03095 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BBB50_03110 ENOG41060NJ transcriptional regulator BBB50_03115 ENOG4108Y51 tRNA-binding protein BBB50_03130 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) BBB50_03135 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BBB50_03145 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) BBB50_03150 ENOG4105X2V dna damage-inducible protein BBB50_03165 ENOG4105DSY exodeoxyribonuclease V, gamma BBB50_03170 ENOG4107QKA exodeoxyribonuclease V beta BBB50_03175 ENOG4107QYX exodeoxyribonuclease v alpha BBB50_03190 ENOG4107QZM n-acetylglutamate synthase BBB50_03200 ENOG4105CA3 membrane-bound lytic murein transglycosylase BBB50_03205 ENOG4105CUZ uba thif-type nad fad binding protein BBB50_03210 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) BBB50_03215 ENOG4105C9B Cysteine desulfurase BBB50_03220 ENOG4107S0N DJ-1 family BBB50_03225 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BBB50_03230 ENOG4105DRB nucleoside-specific channel-forming protein BBB50_03240 ENOG4105K6V RNA polymerase BBB50_03250 ENOG4105EYM Major Facilitator superfamily BBB50_03255 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) BBB50_03265 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) BBB50_03270 ENOG4105M85 Bola protein BBB50_03275 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BBB50_03280 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BBB50_03285 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BBB50_03290 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BBB50_03295 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BBB50_03300 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) BBB50_03305 ENOG4105CJ2 (LipO)protein BBB50_03315 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BBB50_03325 ENOG4105BZU Histidine kinase BBB50_03330 ENOG4105C8J )-transporter BBB50_03340 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) BBB50_03345 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) BBB50_03350 ENOG4105CIN aminoacyl-histidine dipeptidase BBB50_03355 ENOG4105C7N Xanthine uracil vitamin C permease BBB50_03360 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) BBB50_03370 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) BBB50_03375 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BBB50_03380 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) BBB50_03385 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) BBB50_03390 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BBB50_03405 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BBB50_03410 ENOG4107YIM Involved in the transcription termination process (By similarity) BBB50_03415 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) BBB50_03420 ENOG4108ZAI phosphatidylglycerophosphatase a BBB50_03425 ENOG4108T8E UPF0325 protein BBB50_03430 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) BBB50_03435 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BBB50_03440 ENOG4105CE9 30S ribosomal protein S2 BBB50_03445 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) BBB50_03450 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BBB50_03455 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BBB50_03460 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BBB50_03465 ENOG4105KNE Phosphatidate cytidylyltransferase BBB50_03470 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BBB50_03475 ENOG4105DZP Membrane-associated zinc metalloprotease BBB50_03485 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) BBB50_03490 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BBB50_03495 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) BBB50_03500 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BBB50_03505 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BBB50_03510 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BBB50_03515 ENOG4105C0B DNA polymerase III (alpha subunit) BBB50_03520 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) BBB50_03525 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BBB50_03530 ENOG4105N7H Cytochrome BBB50_03535 ENOG4105PY6 Phenolic acid decarboxylase BBB50_03540 ENOG4108YZA Nitrogen regulatory protein pii BBB50_03550 ENOG4105E9H Lytic Murein transglycosylase BBB50_03555 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BBB50_03560 ENOG4105D1A Methyltransferase BBB50_03565 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BBB50_03570 ENOG4108JDX DNA polymerase iii, epsilon subunit BBB50_03580 ENOG4107QPN acyl-Coa dehydrogenase BBB50_03585 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) BBB50_03590 ENOG4105E7A Glutamine amidotransferase BBB50_03595 ENOG4108V3E phosphoribosylglycinamide formyltransferase BBB50_03600 ENOG4105CXB phosphoribosylaminoimidazole synthetase BBB50_03605 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BBB50_03610 ENOG4105BZU Histidine kinase BBB50_03615 ENOG4105FE9 pseudouridine synthase BBB50_03620 ENOG4108DG9 Smr protein MutS2 BBB50_03635 ENOG4105MBR gumn family BBB50_03640 ENOG4105E2D ec 3.2.1.52 BBB50_03650 ENOG4105C59 p-type ATPase BBB50_03655 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BBB50_03660 ENOG4105UYK outer membrane protein a BBB50_03670 ENOG4107RBR Receptor BBB50_03675 ENOG4105Q26 Siderophore-interacting protein BBB50_03680 ENOG4105C0W non-ribosomal peptide synthetase BBB50_03715 ENOG4107R88 Chemotaxis protein (CheV) BBB50_03720 ENOG4105BZU Histidine kinase BBB50_03725 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BBB50_03730 ENOG4108ZC9 flagellar basal-body rod protein flgc BBB50_03735 ENOG4105W00 Flagellar hook capping protein BBB50_03740 ENOG4105BZE flagellar hook protein, FlgE BBB50_03745 ENOG4108KPB Flagellar basal-body rod protein FlgF BBB50_03750 ENOG4105CGA flagellar basal-body rod protein FlgG BBB50_03755 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) BBB50_03760 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) BBB50_03765 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj BBB50_03785 ENOG4105I03 Flagellin BBB50_03790 ENOG4105I03 Flagellin BBB50_03875 ENOG4105C3G gtp-binding protein BBB50_03880 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BBB50_03885 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BBB50_03890 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) BBB50_03895 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) BBB50_03900 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BBB50_03905 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BBB50_03910 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BBB50_03915 ENOG4108YY7 Invasion gene expression up-regulator SirB BBB50_03920 ENOG41063JG Transcriptional regulator BBB50_03925 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BBB50_03930 ENOG4105CGH 5'-nucleotidase BBB50_03935 ENOG4108Z66 YbaK ebsC protein BBB50_03940 ENOG4105C2W permease BBB50_03955 ENOG4105CS1 NAD(P)H quinone oxidoreductase BBB50_03960 ENOG4105K89 arsenate reductase BBB50_03965 ENOG4105ERG peptidase m48, ste24p BBB50_03980 ENOG4105C8Q Methyl-accepting chemotaxis BBB50_03985 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BBB50_03995 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BBB50_04000 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) BBB50_04015 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) BBB50_04020 ENOG4105KUZ arsenate reductase BBB50_04035 ENOG4105QZU Inner membrane protein YfeZ BBB50_04040 ENOG4105EZR dyp-type peroxidase family protein BBB50_04045 ENOG4105I03 Flagellin BBB50_04050 ENOG4105I03 Flagellin BBB50_04055 ENOG4105I03 Flagellin BBB50_04060 ENOG41063QE flagellar protein FlaG BBB50_04065 ENOG4107W9T flagellar hook-associated BBB50_04075 ENOG4105MQ3 flagellar protein FliS BBB50_04080 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BBB50_04085 ENOG4105BZU Histidine kinase BBB50_04090 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BBB50_04095 ENOG4105VQ0 flagellar hook-basal body complex protein fliE BBB50_04100 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) BBB50_04105 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BBB50_04115 ENOG4108JIR Flagellum-specific ATP synthase BBB50_04130 ENOG4105X6C Flagellar basal body-associated protein FliL BBB50_04135 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BBB50_04140 ENOG4105DD5 Flagellar motor switch protein BBB50_04145 ENOG4105VTB flagellar biosynthesis protein fliO BBB50_04150 ENOG4105CN7 Flagellar biosynthetic protein FliP BBB50_04155 ENOG4105VS8 Flagellar biosynthetic protein fliq BBB50_04160 ENOG4105D19 Role in flagellar biosynthesis (By similarity) BBB50_04165 ENOG4105D00 flagellar biosynthetic protein flhB BBB50_04175 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) BBB50_04185 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BBB50_04190 ENOG4105EN6 Membrane BBB50_04195 ENOG4108BPE -transporting atpase BBB50_04200 ENOG4105MH2 YfcL protein BBB50_04205 ENOG4105Q8W reductase BBB50_04210 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) BBB50_04215 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BBB50_04220 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) BBB50_04225 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BBB50_04230 ENOG41090R7 Ferric uptake BBB50_04240 ENOG4105CMU LysR family (Transcriptional regulator BBB50_04245 ENOG4105VAW lrga family BBB50_04250 ENOG41067MG lrgb family BBB50_04255 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) BBB50_04265 ENOG4105EV9 Alpha Beta Hydrolase BBB50_04270 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) BBB50_04275 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 BBB50_04285 ENOG4107QNR UPF0135 protein BBB50_04290 ENOG4105BZN citrate synthase BBB50_04295 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit BBB50_04300 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein BBB50_04305 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) BBB50_04310 ENOG4105E33 succinate dehydrogenase BBB50_04315 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BBB50_04320 ENOG4105C7S Dehydrogenase BBB50_04325 ENOG4105CMV Succinyl-CoA synthetase subunit beta BBB50_04330 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BBB50_04335 ENOG4105FAV ABC, transporter BBB50_04340 ENOG4105FDK ABC transporter BBB50_04345 ENOG4105NXV High-affinity zinc uptake system protein BBB50_04350 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) BBB50_04355 ENOG4105XFK Ferrous iron transport protein A BBB50_04375 ENOG4105C75 arginyL-tRNA synthetase BBB50_04385 ENOG4108JQM Insulinase (Peptidase family M16) BBB50_04390 ENOG4108BY2 phosphohistidine phosphatase BBB50_04395 ENOG4105D7B Flagellar biosynthesis protein flha BBB50_04400 ENOG4105FZW flagellar biosynthesis regulator FlhF BBB50_04405 ENOG4107R21 site-determining protein BBB50_04410 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BBB50_04415 ENOG4108VYJ response regulator receiver protein BBB50_04420 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) BBB50_04425 ENOG4105CBS Chea signal transduction histidine kinase BBB50_04430 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) BBB50_04435 ENOG4107QJE Chromosome Partitioning Protein BBB50_04445 ENOG4108V3W Chemotaxis protein, CheW BBB50_04455 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) BBB50_04460 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) BBB50_04465 ENOG41060IM Heme exporter protein BBB50_04470 ENOG41067VX Heme exporter protein BBB50_04475 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) BBB50_04480 ENOG4105DA4 cytochrome c-type biogenesis protein BBB50_04485 ENOG4107QX9 Thiol disulfide interChange protein BBB50_04490 ENOG4108M1T Cytochrome c-type biogenesis protein BBB50_04500 ENOG410903C (LipO)protein BBB50_04515 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BBB50_04520 ENOG4105M2J Glutaredoxin BBB50_04525 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BBB50_04530 ENOG4105DGU Histone deacetylase BBB50_04545 ENOG4105E68 Sulfatase BBB50_04555 ENOG4106V8H Nucleoid-associated protein BBB50_04565 ENOG4105DFD Na H antiporter BBB50_04570 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BBB50_04575 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein BBB50_04580 ENOG4108EKI Dehydrogenase BBB50_04590 ENOG4105CHH sulfate transporter BBB50_04595 ENOG4105C03 ribonuclease BBB50_04610 ENOG4105EI2 Pseudouridine synthase BBB50_04615 ENOG4108UHJ MAF-like protein BBB50_04620 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein BBB50_04625 ENOG4105VGS 50s ribosomal protein l32 BBB50_04630 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) BBB50_04635 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BBB50_04640 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BBB50_04645 ENOG4105CHR reductase BBB50_04650 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BBB50_04655 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BBB50_04660 ENOG4105YAZ 4-amino-4-deoxychorismate lyase BBB50_04665 ENOG4105HHA aminodeoxychorismate lyase BBB50_04670 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BBB50_04675 ENOG4107QRG dna polymerase iii BBB50_04680 ENOG4105F8V Hydrolase, tatD family BBB50_04685 ENOG4105CI1 PTS System BBB50_04690 ENOG4105C8J )-transporter BBB50_04700 ENOG4108NRW Phospholipase, patatin family BBB50_04705 ENOG4105CA9 Pyruvate kinase BBB50_04710 ENOG4105DAG ROK family BBB50_04715 ENOG4107R88 Chemotaxis protein (CheV) BBB50_04730 ENOG4105DHI Methyltransferase BBB50_04740 ENOG4105DSB aldose 1-epimerase BBB50_04745 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BBB50_04750 ENOG4105E0X reductase BBB50_04760 ENOG4105VUT cytoplasmic protein BBB50_04765 ENOG4105HDK L-asparaginase BBB50_04770 ENOG4105D07 Signal peptide peptidase, SppA BBB50_04775 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BBB50_04780 ENOG4105CIY formyltetrahydrofolate deformylase BBB50_04790 ENOG4105DVT helicase BBB50_04795 ENOG41072GX Peptidase M22 Glycoprotease BBB50_04810 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BBB50_04815 ENOG4105CEY Amp-dependent synthetase and ligase BBB50_04820 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) BBB50_04840 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein BBB50_04845 ENOG4105DK2 UPF0207 protein BBB50_04850 ENOG4105CHM Aminotransferase BBB50_04855 ENOG4105E4F Isochorismate synthase BBB50_04860 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BBB50_04865 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BBB50_04870 ENOG4108IPT Naphthoate synthase BBB50_04875 ENOG4105DNI Converts SHCHC to OSB (By similarity) BBB50_04880 ENOG4105CEY Amp-dependent synthetase and ligase BBB50_04885 ENOG4105DKK Benzoate BBB50_04890 ENOG4108JCI Transcriptional regulator BBB50_04895 ENOG4108N3W hemolysin secretion protein BBB50_04905 ENOG4107S74 Lysophospholipid transporter LplT BBB50_04930 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) BBB50_04935 ENOG4107QMS site-determining protein BBB50_04940 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) BBB50_04945 ENOG4105VNG YcgL domain-containing protein BBB50_04950 ENOG4105CVE Lytic murein transglycosylase BBB50_04955 ENOG4105JQN Transcriptional regulator BBB50_04960 ENOG4105D9N nucleoside BBB50_04965 ENOG410662T chitinase BBB50_04970 ENOG4105CUW cytochrome C-TYPE protein BBB50_04975 ENOG4107QY8 reductase BBB50_04985 ENOG4105JQN Transcriptional regulator BBB50_05005 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BBB50_05040 ENOG4108HPI phosphatidate Cytidylyltransferase BBB50_05050 ENOG4105BZU Histidine kinase BBB50_05065 ENOG4105CNG UPF0061 protein BBB50_05070 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BBB50_05075 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ BBB50_05080 ENOG4105CG6 trap dicarboxylate transporter dctm subunit BBB50_05085 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BBB50_05100 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BBB50_05105 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BBB50_05110 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BBB50_05115 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BBB50_05120 ENOG4105K70 DNA-binding protein BBB50_05125 ENOG4105EIN peptidylprolyl cis-trans isomerase BBB50_05130 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein BBB50_05135 ENOG4105CAT Cytidine monophosphate kinase BBB50_05140 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BBB50_05145 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) BBB50_05150 ENOG4105Q4A inner membrane protein yciS BBB50_05155 ENOG4105CFV Tetratricopeptide repeat protein BBB50_05160 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) BBB50_05165 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase BBB50_05175 ENOG4107R11 Transcriptional regulator BBB50_05185 ENOG4105DCF alanine dehydrogenase BBB50_05190 ENOG4105EW9 transcriptional regulator AsnC family BBB50_05195 ENOG4105CNU cell division protein FtsK BBB50_05200 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) BBB50_05205 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) BBB50_05210 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) BBB50_05220 ENOG4108NVR Methyl-accepting chemotaxis BBB50_05225 ENOG4105K59 histidine triad (HIT) protein BBB50_05255 ENOG4105CEP NADH dehydrogenase BBB50_05265 ENOG4106M3D hemolysin BBB50_05275 ENOG4108JA2 transcriptioN-repair coupling factor BBB50_05285 ENOG4105D60 lipoprotein releasing system transmembrane protein BBB50_05290 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BBB50_05295 ENOG4105D60 lipoprotein releasing system transmembrane protein BBB50_05305 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 BBB50_05310 ENOG4105BZ1 (ABC) transporter BBB50_05315 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) BBB50_05325 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) BBB50_05330 ENOG4105ED1 spovr family BBB50_05335 ENOG4106AKX UPF0229 protein BBB50_05340 ENOG4105CYN Serine protein kinase BBB50_05345 ENOG4105XWI UPF0304 protein BBB50_05355 ENOG4105F1A Pyruvate formate-lyase BBB50_05360 ENOG4108N3W hemolysin secretion protein BBB50_05370 ENOG4105C6N Formate acetyltransferase BBB50_05380 ENOG4108JEH abc transporter atp-binding protein BBB50_05385 ENOG4105E89 ABC transporter BBB50_05390 ENOG4105DSP amino acid AbC transporter BBB50_05395 ENOG4106YG3 ABC transporter BBB50_05400 ENOG4105CGK Exodeoxyribonuclease III BBB50_05405 ENOG4105C8Q Methyl-accepting chemotaxis BBB50_05410 ENOG4106428 Protein of unknown function (DUF2496) BBB50_05415 ENOG4108URS primosomal replication protein n'' BBB50_05420 ENOG4105EJ9 Membrane BBB50_05425 ENOG4105DVT helicase BBB50_05430 ENOG4105ZU8 porin-like protein H BBB50_05445 ENOG4105D58 Diguanylate phosphodiesterase BBB50_05450 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) BBB50_05455 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) BBB50_05460 ENOG4105C8N cysteinyl-tRNA synthetase BBB50_05465 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) BBB50_05470 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BBB50_05475 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) BBB50_05480 ENOG4105C4M (Ubiquinol oxidase) subunit I BBB50_05485 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BBB50_05495 ENOG4105KJB cyd operon protein YbgE BBB50_05500 ENOG4107YD3 Thioesterase BBB50_05505 ENOG4105E02 MotA TolQ exbB proton channel BBB50_05510 ENOG4105M8F Biopolymer transport protein exbD tolR BBB50_05520 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) BBB50_05525 ENOG4105KCK Peptidoglycan-associated lipoprotein BBB50_05535 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) BBB50_05545 ENOG4105BZU Histidine kinase BBB50_05550 ENOG4108RNS Exports L-alanine (By similarity) BBB50_05555 ENOG4105EIP mannose-6-phosphate isomerase BBB50_05560 ENOG4105DM4 PTS System BBB50_05565 ENOG4106R3P AraC family transcriptional regulator BBB50_05575 ENOG4108YRF PTS System BBB50_05580 ENOG4105DM4 PTS System BBB50_05585 ENOG4105DM4 PTS System BBB50_05595 ENOG4105C26 Dehydrogenase BBB50_05600 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BBB50_05605 ENOG4105VYA Uncharacterized conserved protein (DUF2132) BBB50_05615 ENOG4105CVP deoxyribo-dipyrimidine photolyase BBB50_05725 ENOG4108NYK Tape measure protein BBB50_05745 ENOG4108YGG dna repair protein BBB50_05755 ENOG4108478 ec 3.2.1.18 BBB50_05760 ENOG4105CE4 GlcNAc 6-P deacetylase BBB50_05765 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) BBB50_05770 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) BBB50_05780 ENOG4108ERU trap dicarboxylate transporter subunit DctP BBB50_05785 ENOG41069H7 transport system small permease component BBB50_05790 ENOG4105CG6 trap dicarboxylate transporter dctm subunit BBB50_05800 ENOG4105QEK Transcriptional regulator BBB50_05805 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) BBB50_05810 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) BBB50_05830 ENOG4105CVR type I restriction-modification system BBB50_05850 ENOG4105DZR Type I site-specific deoxyribonuclease BBB50_05870 ENOG4105C0D helicase BBB50_05880 ENOG4105DFP Integrase BBB50_05905 ENOG4105DY2 Paraquat-inducible protein b BBB50_05910 ENOG4105F1S paraquat-inducible protein a BBB50_05940 ENOG4108R86 Transcriptional regulator BBB50_05945 ENOG4105C26 Dehydrogenase BBB50_05950 ENOG4105MTM Protein of unknown function (DUF1496) BBB50_05960 ENOG41067SE Tetr family transcriptional regulator BBB50_05965 ENOG4107QPN acyl-Coa dehydrogenase BBB50_05975 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) BBB50_05980 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate BBB50_05985 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) BBB50_05995 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BBB50_06000 ENOG4105RKX Protein of unknown function (DUF2498) BBB50_06005 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BBB50_06010 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BBB50_06015 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BBB50_06035 ENOG4105HP8 regulator of competence-specific genes BBB50_06040 ENOG4105ETE Transcriptional regulator (LacI family BBB50_06050 ENOG4106WF9 DNA-binding transcriptional regulator TorR BBB50_06055 ENOG4107S90 membrAne BBB50_06060 ENOG4106371 Methyltransferase BBB50_06065 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) BBB50_06070 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) BBB50_06075 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) BBB50_06080 ENOG4105EW9 transcriptional regulator AsnC family BBB50_06090 ENOG4105CCT upf0313 protein BBB50_06115 ENOG4105DZ2 Transcriptional regulator BBB50_06120 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BBB50_06130 ENOG4105K9H YciI-like protein BBB50_06135 ENOG4105NAU thioesterase Superfamily protein BBB50_06140 ENOG4107835 probably involved in intracellular septation (By similarity) BBB50_06150 ENOG4105GFG DUF218 domain BBB50_06155 ENOG4108535 NAD dependent epimerase/dehydratase family BBB50_06165 ENOG4105TMB Formate nitrite transporter BBB50_06185 ENOG4107QY8 reductase BBB50_06205 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase BBB50_06220 ENOG4108JQ2 peptide transport system atp-binding protein BBB50_06225 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein BBB50_06230 ENOG4108EU3 peptide transport system, permease BBB50_06235 ENOG4108I5W peptide transport system, permease protein BBB50_06240 ENOG4108J59 Extracellular solute-binding protein, family 5 BBB50_06245 ENOG4105E51 psp operon transcriptional activator BBB50_06250 ENOG41087YS Phage shock protein A BBB50_06265 ENOG4105C1P efflux transporter, rnd family, mfp subunit BBB50_06280 ENOG4108R3E Dna-3-methyladenine glycosylase i BBB50_06285 ENOG4105C28 cystathionine BBB50_06290 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BBB50_06295 ENOG4105C8J )-transporter BBB50_06300 ENOG4108W1A pseudouridine synthase BBB50_06305 ENOG4108T9J Cdp-alcohol phosphatidyltransferase BBB50_06310 ENOG4108VGW abc transporter atp-binding protein BBB50_06315 ENOG4105CXZ ABC transporter, permease BBB50_06320 ENOG4105VNH ABC transporter solute-binding protein BBB50_06330 ENOG4105XZD Fe-S protein BBB50_06340 ENOG4107QWP ABC-2 type transporter BBB50_06345 ENOG4105CJ1 ABC, transporter BBB50_06355 ENOG4105C44 Serine transporter BBB50_06365 ENOG4105CJW magnesium transporter BBB50_06370 ENOG4105BZU Histidine kinase BBB50_06375 ENOG4105BZU Histidine kinase BBB50_06385 ENOG4105KXC Collagenase BBB50_06415 ENOG4108N3W hemolysin secretion protein BBB50_06435 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BBB50_06455 ENOG4105CFI type iii restriction protein res subunit BBB50_06460 ENOG4105I08 Pseudouridine synthase BBB50_06465 ENOG4105C2C drug resistance transporter, Bcr CflA BBB50_06475 ENOG4105CGD Nad-dependent epimerase dehydratase BBB50_06480 ENOG4105UQX Mate efflux family protein BBB50_06485 ENOG4108I0Y (ABC) transporter BBB50_06500 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) BBB50_06510 ENOG4105E3Q saccharopine dehydrogenase BBB50_06515 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) BBB50_06520 ENOG4105CDV Ompa motb domain protein BBB50_06525 ENOG4105DFG type I secretion outer membrane protein BBB50_06550 ENOG4105F04 LysR family Transcriptional regulator BBB50_06560 ENOG4108VKG metal-dependent hydrolase BBB50_06575 ENOG41090FY type IV pilus biogenesis stability protein PilW BBB50_06580 ENOG4105CVG Homoserine O-transsuccinylase BBB50_06600 ENOG4107V40 secretion protein, HlyD family BBB50_06615 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BBB50_06620 ENOG4106YYS transcriptional regulatory protein BBB50_06630 ENOG4107R88 Chemotaxis protein (CheV) BBB50_06645 ENOG4105BZU Histidine kinase BBB50_06670 ENOG4105F0Z galactose-1-phosphate uridylyltransferase BBB50_06675 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BBB50_06680 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) BBB50_06685 ENOG4106TD9 Diguanylate cyclase BBB50_06690 ENOG4105BZU Histidine kinase BBB50_06700 ENOG4105C7K acetolactate synthase BBB50_06705 ENOG4107FQX Alpha-acetolactate decarboxylase BBB50_06720 ENOG4105CH6 catalase BBB50_06730 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BBB50_06740 ENOG4108TWJ NADH dehydrogenase subunit 5 BBB50_06745 ENOG4105DUM transcriptional regulator, lysR family BBB50_06750 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) BBB50_06780 ENOG4105C9Q fumarate hydratase class II BBB50_06790 ENOG4105C4M (Ubiquinol oxidase) subunit I BBB50_06795 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BBB50_06800 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BBB50_06805 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BBB50_06810 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BBB50_06820 ENOG4107QZV Type I secretion membrane fusion protein BBB50_06835 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) BBB50_06840 ENOG4105CS2 ec 3.2.1.21 BBB50_06845 ENOG4105DDV Transcriptional regulator (LacI family BBB50_06850 ENOG4105M4H endoribonuclease L-psp BBB50_06855 ENOG4105XEP YhcH YjgK YiaL family protein BBB50_06860 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BBB50_06865 ENOG4105E98 transcriptional regulator DeoR family BBB50_06870 ENOG4108IJ9 (ABC) transporter BBB50_06875 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BBB50_06905 ENOG4109015 Biopolymer transport protein exbD tolR BBB50_06910 ENOG41067XB TonB family BBB50_06930 ENOG4107QI1 Mate efflux family protein BBB50_06940 ENOG4105FGM Fructosamine kinase BBB50_06950 ENOG4107TT5 NLP P60 protein BBB50_06955 ENOG4105C8Q Methyl-accepting chemotaxis BBB50_06965 ENOG4106IUH DTW domain containing protein BBB50_06970 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) BBB50_06995 ENOG4105CVM Molybdenum cofactor synthesis domain protein BBB50_07000 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) BBB50_07005 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BBB50_07010 ENOG4107A5B Binding-protein-dependent transport systems, inner membrane component BBB50_07020 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BBB50_07025 ENOG4105BZU Histidine kinase BBB50_07030 ENOG4105C5H ABC transporter BBB50_07035 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BBB50_07055 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) BBB50_07065 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BBB50_07070 ENOG4105QAX Iron-sulfur BBB50_07085 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BBB50_07095 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) BBB50_07110 ENOG4105QNR S1 RNA binding domain protein BBB50_07115 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BBB50_07120 ENOG4105DY2 Paraquat-inducible protein b BBB50_07125 ENOG4105H2K paraquat-inducible protein a BBB50_07130 ENOG4105BZ1 (ABC) transporter BBB50_07135 ENOG4108ZGC gaf domain protein BBB50_07140 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) BBB50_07145 ENOG4105CN1 protease BBB50_07155 ENOG4105CD8 aminopeptidase N BBB50_07165 ENOG4105C7I Dehydrogenase BBB50_07170 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) BBB50_07175 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) BBB50_07180 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BBB50_07190 ENOG4105C5H ABC transporter BBB50_07205 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) BBB50_07210 ENOG4105DAN ATP-dependent protease BBB50_07215 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) BBB50_07300 ENOG4105EUK rtx toxin RtxA BBB50_07305 ENOG4108RC6 RTX toxin BBB50_07330 ENOG4105BZU Histidine kinase BBB50_07345 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i BBB50_07360 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) BBB50_07370 ENOG4105C59 p-type ATPase BBB50_07385 ENOG4105DS0 Transcriptional regulator, Crp Fnr family BBB50_07390 ENOG4105Q9Y Universal stress protein BBB50_07395 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) BBB50_07435 ENOG4105C5S asparaginyl-tRNA synthetase BBB50_07445 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BBB50_07455 ENOG4105CGF Aromatic amino acid aminotransferase BBB50_07470 ENOG4105C8Q Methyl-accepting chemotaxis BBB50_07485 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i BBB50_07500 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) BBB50_07510 ENOG4105C59 p-type ATPase BBB50_07525 ENOG4105DS0 Transcriptional regulator, Crp Fnr family BBB50_07530 ENOG4105Q9Y Universal stress protein BBB50_07535 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) BBB50_07555 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BBB50_07560 ENOG4105F38 ABC transporter, permease BBB50_07565 ENOG4105D38 putrescine abc transporter BBB50_07570 ENOG4107RUE extracellular solute-binding protein family 1 BBB50_07575 ENOG4107RUE extracellular solute-binding protein family 1 BBB50_07590 ENOG4105BZG amino acid carrier protein BBB50_07595 ENOG410829K Lysine exporter protein (Lyse ygga) BBB50_07625 ENOG4108WC9 type VI secretion system effector, hcp1 family BBB50_07630 ENOG4105CTD carboxy-peptidase BBB50_07635 ENOG4105C8Q Methyl-accepting chemotaxis BBB50_07640 ENOG4105C0R drug resistance transporter emrb qaca subfamily BBB50_07645 ENOG4105CW7 secretion protein, HlyD family BBB50_07650 ENOG4105ENJ RND efflux system, outer membrane lipoprotein BBB50_07660 ENOG4105C1J atp-dependent rna helicase BBB50_07665 ENOG4107SDU Methyl-accepting chemotaxis BBB50_07670 ENOG4108N3W hemolysin secretion protein BBB50_07675 ENOG4105C8Q Methyl-accepting chemotaxis BBB50_07680 ENOG4108V3W Chemotaxis protein, CheW BBB50_07685 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) BBB50_07695 ENOG4105BZU Histidine kinase BBB50_07700 ENOG4105CBS Chea signal transduction histidine kinase BBB50_07705 ENOG4105CBS Chea signal transduction histidine kinase BBB50_07715 ENOG4108VYJ response regulator receiver protein BBB50_07720 ENOG4108NVR Methyl-accepting chemotaxis BBB50_07725 ENOG4105KPY Small multidrug resistance protein BBB50_07730 ENOG4105CVP deoxyribo-dipyrimidine photolyase BBB50_07735 ENOG4105C0R drug resistance transporter emrb qaca subfamily BBB50_07740 ENOG4105EJC lysr family transcriptional regulator BBB50_07750 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) BBB50_07755 ENOG4105R8A Heat shock protein BBB50_07765 ENOG4105CQ7 ATP-dependent helicase BBB50_07795 ENOG4105BZU Histidine kinase BBB50_07805 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB BBB50_07810 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB BBB50_07815 ENOG4105BZU Histidine kinase BBB50_07825 ENOG4105BZU Histidine kinase BBB50_07845 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BBB50_07850 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BBB50_07855 ENOG410667J hydrolase BBB50_07865 ENOG4107QXX ABC transporter BBB50_07870 ENOG4105EZ7 amino acid ABC transporter BBB50_07875 ENOG4105DRP amino acid AbC transporter BBB50_07880 ENOG4105CDA abc transporter atp-binding protein BBB50_07885 ENOG4108MN8 Membrane BBB50_07890 ENOG4108Z0T Part of a sulfur-relay system (By similarity) BBB50_07895 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 BBB50_07900 ENOG4105DR4 Methyltransferase BBB50_07905 ENOG4106TD9 Diguanylate cyclase BBB50_07920 ENOG4105BZU Histidine kinase BBB50_07925 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BBB50_07930 ENOG4108RXX maleylacetoacetate isomerase BBB50_07940 ENOG4105F1J Homogentisate 1,2-dioxygenase BBB50_07945 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BBB50_07950 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BBB50_07965 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BBB50_07970 ENOG4105C7F AcnD-accessory protein PrpF BBB50_07975 ENOG4108I0Z Aconitate hydratase BBB50_07980 ENOG4105BZN citrate synthase BBB50_07985 ENOG4105CR4 methylisocitrate lyase BBB50_07990 ENOG41073TP transcriptional regulator BBB50_08020 ENOG4107SDZ Galactoside transport system permease protein mglC BBB50_08025 ENOG4105C2J ABC transporter BBB50_08060 ENOG4107EXC regulatoR BBB50_08065 ENOG4105EB3 Histidine kinase BBB50_08070 ENOG4105RW8 MltA-interacting MipA family protein BBB50_08075 ENOG4108MJ5 VirK protein BBB50_08080 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BBB50_08085 ENOG4105BZU Histidine kinase BBB50_08090 ENOG4105C8P )-transporter BBB50_08095 ENOG4108NVR Methyl-accepting chemotaxis BBB50_08100 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BBB50_08115 ENOG4105D9U N-acetyltransferase BBB50_08120 ENOG4108JU8 Transcriptional regulator BBB50_08130 ENOG4105CM6 amino acid regulated cytosolic protein BBB50_08145 ENOG4105CRQ synthase (Component I) BBB50_08150 ENOG4105P8F nudix hydrolase BBB50_08155 ENOG4105C44 Serine transporter BBB50_08160 ENOG4105EJQ L-serine dehydratase BBB50_08165 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BBB50_08170 ENOG4108NVR Methyl-accepting chemotaxis BBB50_08175 ENOG4105C5S asparaginyl-tRNA synthetase BBB50_08185 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BBB50_08195 ENOG4105CGF Aromatic amino acid aminotransferase BBB50_08210 ENOG4105C8Q Methyl-accepting chemotaxis BBB50_08215 ENOG4105DJ9 glucan biosynthesis protein BBB50_08220 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) BBB50_08225 ENOG41060NJ transcriptional regulator BBB50_08230 ENOG410901P UPF0249 protein BBB50_08235 ENOG4105F8D glycoside hydrolase family 4 BBB50_08240 ENOG4105VCP PTS System BBB50_08250 ENOG4105VZJ PTS System BBB50_08260 ENOG4105C94 Transporter BBB50_08265 ENOG41067TZ transcriptional regulator, MarR family BBB50_08280 ENOG4105CG6 trap dicarboxylate transporter dctm subunit BBB50_08290 ENOG4105CH5 extracellular solute-binding protein, family 7 BBB50_08305 ENOG4105C5X domain protein BBB50_08310 ENOG4105EAQ (twin-arginine translocation) pathway signal BBB50_08315 ENOG4105DIT ErfK YbiS YcfS YnhG family protein BBB50_08340 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) BBB50_08350 ENOG4105S8Q sugar efflux transporter BBB50_08360 ENOG4105C72 UPF0176 protein BBB50_08365 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BBB50_08370 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BBB50_08375 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BBB50_08380 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BBB50_08385 ENOG4107QK7 reductase BBB50_08410 ENOG4105C8Q Methyl-accepting chemotaxis BBB50_08425 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) BBB50_08430 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) BBB50_08445 ENOG4108YZT Adenosylcobinamide kinase BBB50_08450 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) BBB50_08455 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) BBB50_08460 ENOG4105E0X reductase BBB50_08465 ENOG4108ETY sodium dicarboxylate symporter BBB50_08470 ENOG4105CJB Exodeoxyribonuclease I BBB50_08480 ENOG41067MG lrgb family BBB50_08485 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) BBB50_08495 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR BBB50_08505 ENOG4105FQ6 thiopurine methyltransferase BBB50_08520 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) BBB50_08525 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BBB50_08530 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BBB50_08540 ENOG4105BZU Histidine kinase BBB50_08570 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BBB50_08575 ENOG4105WH1 Two component transcriptional regulator luxr family BBB50_08580 ENOG4105CQ2 DNA polymerase BBB50_08585 ENOG4105BZU Histidine kinase BBB50_08595 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BBB50_08610 ENOG4105CZE histidine utilization repressor BBB50_08615 ENOG4105CI2 imidazolone-5-propionate hydrolase BBB50_08620 ENOG41088SP formiminoglutamate hydrolase BBB50_08625 ENOG4105CGP Urocanate hydratase BBB50_08630 ENOG4105C84 Histidine ammonia-lyase BBB50_08640 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap BBB50_08650 ENOG4105CQB FAD linked oxidase domain protein BBB50_08665 ENOG4108ZG0 Ompa motb domain protein BBB50_08685 ENOG4105C8V SAICAR synthetase BBB50_08695 ENOG4107R1I NAD-dependent malic enzyme BBB50_08705 ENOG4107GZ4 SanA protein BBB50_08710 ENOG4105BZU Histidine kinase BBB50_08715 ENOG4105C9B Cysteine desulfurase BBB50_08725 ENOG4105C3M thioredoxin reductase BBB50_08730 ENOG4108JJ9 ABC, transporter BBB50_08735 ENOG4108JJ8 (ABC) transporter BBB50_08740 ENOG4105FE9 pseudouridine synthase BBB50_08745 ENOG4107RTD sua5 ycio yrdc ywlc family protein BBB50_08750 ENOG4105DB7 PHP domain protein BBB50_08760 ENOG4105CRQ synthase (Component I) BBB50_08765 ENOG4105DDQ anthranilate synthase BBB50_08770 ENOG4108I0Q anthranilate phosphoribosyltransferase BBB50_08775 ENOG4105DK0 Indole-3-glycerol phosphate synthase BBB50_08780 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BBB50_08785 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) BBB50_08790 ENOG4105CK2 sodium dicarboxylate symporter BBB50_08795 ENOG4107104 thymidine kinase BBB50_08800 ENOG4105C9M aspartyl-trna synthetase BBB50_08805 ENOG41081XQ Conserved Protein BBB50_08810 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) BBB50_08815 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) BBB50_08820 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) BBB50_08835 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BBB50_08845 ENOG4105CUX Signal transduction histidine kinase BBB50_08870 ENOG4105DWU Membrane BBB50_08880 ENOG4105DY8 decarboxylase BBB50_08885 ENOG4106KNT transcriptional regulator BBB50_08890 ENOG4108EKI Dehydrogenase BBB50_08895 ENOG41090BQ Glutaredoxin BBB50_08905 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BBB50_08910 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) BBB50_08915 ENOG4105VEQ Cold shock protein BBB50_08925 ENOG4108R99 pseudouridine synthase BBB50_08930 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BBB50_08935 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BBB50_08940 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BBB50_08945 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BBB50_08950 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BBB50_08955 ENOG4105CIH Imidazole acetol-phosphate transaminase BBB50_08960 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BBB50_08965 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BBB50_08970 ENOG4107S6Z Na H antiporter BBB50_08980 ENOG4107RE1 Inosine-guanosine kinase BBB50_08985 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BBB50_08990 ENOG41075W9 High frequency lysogenization protein HflD homolog BBB50_08995 ENOG4107QTF adenylosuccinate lyase BBB50_09005 ENOG4105RHG BBB50_09015 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BBB50_09030 ENOG4107FW0 short-chain dehydrogenase reductase BBB50_09040 ENOG4105D0M Protease HtpX homolog BBB50_09050 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) BBB50_09055 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BBB50_09060 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BBB50_09065 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BBB50_09070 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BBB50_09075 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) BBB50_09080 ENOG4105D1H recombination factor protein RarA BBB50_09090 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BBB50_09095 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) BBB50_09100 ENOG4105BZU Histidine kinase BBB50_09105 ENOG4108JJB ABC transporter BBB50_09110 ENOG4105C7J ABC transporter, permease BBB50_09120 ENOG4105VYA Uncharacterized conserved protein (DUF2132) BBB50_09125 ENOG4105PQ6 UPF0208 membrane protein BBB50_09130 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BBB50_09135 ENOG4108DNC Involved in acetate metabolism (By similarity) BBB50_09140 ENOG4105CHF Glutathione S-transferase BBB50_09145 ENOG4108JQ7 (ABC) transporter BBB50_09150 ENOG4105C3U ABC transporter BBB50_09155 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BBB50_09160 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BBB50_09165 ENOG4107QSI ABC, transporter BBB50_09180 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BBB50_09185 ENOG4105BZU Histidine kinase BBB50_09190 ENOG4105BZU Histidine kinase BBB50_09195 ENOG4105BZU Histidine kinase BBB50_09205 ENOG4107YTP response regulator receiver protein BBB50_09220 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BBB50_09240 ENOG4108V1U phospholipid-binding protein BBB50_09265 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BBB50_09270 ENOG41082YX Transcriptional regulator, arsr family BBB50_09280 ENOG4105BZU Histidine kinase BBB50_09300 ENOG4105C29 acyl-CoA thioesterase BBB50_09305 ENOG4108XM1 transcriptional regulator AsnC family BBB50_09315 ENOG4105ERU peptidase BBB50_09320 ENOG4105UBK short-chain dehydrogenase reductase BBB50_09330 ENOG4105KRS Proteinase inhibitor BBB50_09335 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BBB50_09340 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) BBB50_09345 ENOG4107QMP dna polymerase iii subunits gamma and tau BBB50_09350 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BBB50_09355 ENOG4105WD1 Membrane BBB50_09365 ENOG4105I93 response regulator BBB50_09370 ENOG4105EJC lysr family transcriptional regulator BBB50_09375 ENOG41069NU Nitroreductase BBB50_09380 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BBB50_09385 ENOG4105CHU acetyl-coa acetyltransferase BBB50_09400 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation BBB50_09405 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation BBB50_09415 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase BBB50_09420 ENOG4108GAE asmA family BBB50_09425 ENOG4105DBI uridine monophosphokinase BBB50_09435 ENOG4105D1F ATP-binding protein BBB50_09440 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BBB50_09450 ENOG4108I5U Uridine phosphorylase BBB50_09470 ENOG4105BZU Histidine kinase BBB50_09475 ENOG4108ZAF Molybdopterin BBB50_09480 ENOG4105M00 molybdopterin converting factor, subunit 1 BBB50_09485 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BBB50_09490 ENOG4108RIR Molybdenum cofactor biosynthesis protein BBB50_09495 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BBB50_09500 ENOG4105CHW UPF0052 protein BBB50_09510 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BBB50_09520 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BBB50_09535 ENOG4108R3D Electron transport complex BBB50_09545 ENOG4105D6A Electron transport complex BBB50_09550 ENOG4108UQQ Electron transport complex BBB50_09555 ENOG4105DZB Electron transport complex BBB50_09560 ENOG4105CSM endonuclease III BBB50_09565 ENOG4108UYE Lactoylglutathione lyase BBB50_09570 ENOG4106WH9 Protein of unknown function (DUF2753) BBB50_09575 ENOG4105EIY sodium-type flagellar protein motY BBB50_09585 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) BBB50_09590 ENOG4105D3Y Na H antiporter BBB50_09595 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase BBB50_09600 ENOG4105E96 Colicin v production protein BBB50_09605 ENOG4108S3P Sporulation domain protein BBB50_09610 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BBB50_09615 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) BBB50_09620 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BBB50_09630 ENOG4105CX6 glutaminyL-tRNA synthetase BBB50_09635 ENOG4105CI1 PTS System BBB50_09640 ENOG4105CE4 GlcNAc 6-P deacetylase BBB50_09645 ENOG4105E2R ROK family BBB50_09650 ENOG4105CKD glutathione-regulated potassium-efflux system protein BBB50_09655 ENOG4105CAQ asparagine synthetase BBB50_09660 ENOG4105MDZ Transcriptional activator rfaH BBB50_09665 ENOG4105DUX Transporter BBB50_09670 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BBB50_09675 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BBB50_09680 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) BBB50_09685 ENOG4108TU9 TRANSCRIPTIONal BBB50_09700 ENOG4108RE9 Phosphodiesterase BBB50_09705 ENOG4105ECP epimerase BBB50_09710 ENOG4105E1F short-chain dehydrogenase reductase BBB50_09715 ENOG4107QR8 Thioredoxin BBB50_09720 ENOG4107QX8 SPFH domain, Band 7 family protein BBB50_09725 ENOG4105G5H Membrane BBB50_09730 ENOG4108Z6Z Transcriptional regulator BBB50_09740 ENOG41081QG Porin Gram-negative type BBB50_09745 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BBB50_09750 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) BBB50_09755 ENOG4105EXN Sulfate transport protein CysZ BBB50_09760 ENOG4105C6T cysteine synthase BBB50_09770 ENOG4105KZ7 phosphocarrier protein hpr BBB50_09780 ENOG4105C5Y PTS System BBB50_09785 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family BBB50_09790 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BBB50_09795 ENOG4105C9A Phoh family BBB50_09800 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BBB50_09805 ENOG4108JU5 Magnesium and cobalt efflux protein BBB50_09810 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) BBB50_09815 ENOG4107PAI alpha helical protein BBB50_09820 ENOG4105C8T Leucyl-tRNA synthetase BBB50_09825 ENOG4108U2H Rare lipoprotein B BBB50_09830 ENOG4105DJF DNA polymerase III, delta' subunit BBB50_09835 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) BBB50_09840 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) BBB50_09845 ENOG4105CJN penicillin-binding protein BBB50_09850 ENOG4105CNI cell division protein FtsW BBB50_09855 ENOG4105K6T rare lipoprotein A BBB50_09860 ENOG4105DZ1 carboxypeptidase BBB50_09865 ENOG4108Z43 UPF0250 protein BBB50_09870 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) BBB50_09875 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BBB50_09885 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BBB50_09905 ENOG4105D75 Capsular exopolysaccharide family BBB50_09910 ENOG4105DAY polysaccharide export protein BBB50_09920 ENOG4105D3Q Sugar transferase BBB50_09935 ENOG4108MA4 Peptidase M66 BBB50_09950 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family BBB50_09960 ENOG4105Q84 sucrose synthase BBB50_09970 ENOG4105D7W serine acetyltransferase BBB50_09990 ENOG4108UW5 maltose o-acetyltransferase BBB50_10000 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BBB50_10005 ENOG4107ZF2 Phosphatase BBB50_10010 ENOG4105BZS acriflavin resistance protein BBB50_10040 ENOG4105CG3 alpha amylase, catalytic region BBB50_10045 ENOG4105C5Y PTS System BBB50_10050 ENOG4105D4X repressor BBB50_10055 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BBB50_10060 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BBB50_10065 ENOG4108UMI ABC transporter, permease BBB50_10070 ENOG4105D01 (LipO)protein BBB50_10075 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein BBB50_10080 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) BBB50_10085 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) BBB50_10095 ENOG4105BZU Histidine kinase BBB50_10100 ENOG4105EWT decarboxylase family BBB50_10105 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease BBB50_10110 ENOG4105M08 Membrane BBB50_10115 ENOG4105ETT transcriptional Regulator, LysR family BBB50_10125 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) BBB50_10135 ENOG4105E14 MotA TolQ exbB proton channel BBB50_10145 ENOG4105CTB Polyprenyl synthetase BBB50_10150 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) BBB50_10155 ENOG4105DR9 pseudouridine synthase BBB50_10160 ENOG4105WP7 tRNA pseudouridine synthase C BBB50_10175 ENOG4108428 Inherit from COG: -acetyltransferase BBB50_10185 ENOG4108UPT UPF0178 protein BBB50_10190 ENOG4105CFC Transporter BBB50_10200 ENOG4105NRA 50s ribosomal protein l31 type b BBB50_10205 ENOG4108R96 Methyltransferase, YaeB family BBB50_10210 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BBB50_10235 ENOG4108RS6 transposase BBB50_10240 ENOG4107QIK phosphoribosylformylglycinamidine synthase BBB50_10250 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) BBB50_10260 ENOG4108Z6B deaminase BBB50_10265 ENOG4105CFC Transporter BBB50_10300 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BBB50_10305 ENOG4105CFG Acts as a chaperone (By similarity) BBB50_10310 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BBB50_10315 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BBB50_10320 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BBB50_10325 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) BBB50_10330 ENOG4105VDB UPF0125 protein BBB50_10335 ENOG4108Z1B Cyclase dehydrase BBB50_10340 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BBB50_10350 ENOG4105DFP Integrase BBB50_10360 ENOG4105F88 accessory colonization factor AcfD BBB50_10370 ENOG4105DR5 peptidase BBB50_10385 ENOG4105C8Q Methyl-accepting chemotaxis BBB50_10390 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) BBB50_10405 ENOG4108VEY type ii secretion system BBB50_10410 ENOG4107QHF type ii secretion system protein e BBB50_10430 ENOG4105GRU toxin co-regulated pilus biosynthesis outer membrane protein C BBB50_10445 ENOG4105XB6 Toxin coregulated pilin BBB50_10460 ENOG4107RK6 Methyl-accepting chemotaxis BBB50_10465 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BBB50_10485 ENOG4105C26 Dehydrogenase BBB50_10555 ENOG4105DZ0 fad dependent oxidoreductase BBB50_10560 ENOG4108Z4U Ferredoxin BBB50_10575 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase BBB50_10580 ENOG4105YGP holo-ACP synthase CitX BBB50_10585 ENOG4105CHY citrate lyase, alpha BBB50_10590 ENOG4105CI0 Citrate lyase BBB50_10595 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) BBB50_10600 ENOG4105DUA (citrate (pro-3S)-lyase ligase BBB50_10615 ENOG4107QSA Oxaloacetate decarboxylase BBB50_10620 ENOG4105D9Q decarboxylase (Beta subunit) BBB50_10625 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BBB50_10630 ENOG4106YYS transcriptional regulatory protein BBB50_10650 ENOG4105MWK D-amino acid dehydrogenase, small subunit BBB50_10655 ENOG4105BZG amino acid carrier protein BBB50_10660 ENOG4105EUZ Beta-lactamase domain protein BBB50_10665 ENOG41064T2 transcriptional regulator, lysR family BBB50_10675 ENOG4105E0A ABC, transporter BBB50_10680 ENOG4105TVJ transport system, permease BBB50_10685 ENOG4105DQ5 transport system permease protein BBB50_10690 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein BBB50_10700 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BBB50_10705 ENOG4105E4F Isochorismate synthase BBB50_10710 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BBB50_10715 ENOG4105WQI isochorismatase BBB50_10720 ENOG4106HK8 GPR1 FUN34 yaaH family protein BBB50_10730 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BBB50_10735 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BBB50_10740 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BBB50_10755 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BBB50_10760 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) BBB50_10765 ENOG4105N21 Membrane BBB50_10770 ENOG4105CUT histidyl-tRNA synthetase BBB50_10775 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) BBB50_10785 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BBB50_10790 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BBB50_10795 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BBB50_10800 ENOG4105WVQ Fe-S assembly protein IscX BBB50_10805 ENOG4108ZIT Ferredoxin, 2FE-2S BBB50_10810 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB BBB50_10815 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) BBB50_10820 ENOG4108Z4V iron-sulfur cluster assembly BBB50_10825 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins BBB50_10830 ENOG4105C3J Cysteine desulfurase BBB50_10835 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family BBB50_10840 ENOG4105CVS RNA methyltransferase TrmH family, group 1 BBB50_10845 ENOG4105ECY inositol monophosphatase BBB50_10850 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BBB50_10855 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BBB50_10860 ENOG4105VIE preprotein translocase, subunit YajC BBB50_10865 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BBB50_10875 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) BBB50_10880 ENOG4105W87 Cbs domain BBB50_10885 ENOG4108I9X Isocitrate lyase BBB50_10890 ENOG4107QP3 malate synthase g BBB50_10895 ENOG4105C5Q Transcriptional regulator BBB50_10900 ENOG4105D3R alkyl hydroperoxide reductase BBB50_10905 ENOG4106N3A copper homeostasis protein cutc BBB50_10910 ENOG4105CSR polyphosphate kinase 2 BBB50_10920 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BBB50_10925 ENOG4105E2Z phosphate ABC transporter (Permease BBB50_10930 ENOG4105C8U phosphate abc transporter BBB50_10935 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BBB50_10940 ENOG4105C9X ppx gppa phosphatase BBB50_10950 ENOG4105BZU Histidine kinase BBB50_10955 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BBB50_10960 ENOG4105DH7 May be involved in recombination (By similarity) BBB50_10965 ENOG4105CFP Peptidase U32 BBB50_10970 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding BBB50_11015 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BBB50_11020 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BBB50_11025 ENOG4105C34 Pseudouridine synthase BBB50_11030 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane BBB50_11035 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA BBB50_11045 ENOG4107XW0 Spermidine putrescine ABC transporter periplasmic spermidine putrescine-binding protein BBB50_11050 ENOG4108K0B C-di-gmp phosphodiesterase BBB50_11055 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BBB50_11060 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) BBB50_11065 ENOG4107SC1 transglycosylase BBB50_11070 ENOG4105C5H ABC transporter BBB50_11085 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) BBB50_11090 ENOG4108HRK Histidine kinase BBB50_11095 ENOG4108NEV two component transcriptional regulator, LytTR family BBB50_11100 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) BBB50_11105 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) BBB50_11110 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BBB50_11130 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BBB50_11135 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase BBB50_11140 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BBB50_11145 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BBB50_11150 ENOG4105DTN riboflavin biosynthesis protein ribF BBB50_11155 ENOG4105CJR Integral membrane protein (MviN BBB50_11160 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) BBB50_11165 ENOG41080HT Transcriptional regulator, arsr family BBB50_11170 ENOG41063Z6 transcriptional regulator, lysR family BBB50_11180 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BBB50_11185 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) BBB50_11190 ENOG4105HF0 Membrane BBB50_11195 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase BBB50_11200 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BBB50_11210 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) BBB50_11215 ENOG4105CPC Aldo Keto reductase BBB50_11225 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BBB50_11230 ENOG4105CRK lysyL-tRNA synthetase BBB50_11235 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BBB50_11240 ENOG4105CWM branched-chain amino acid transport system II carrier protein BBB50_11245 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) BBB50_11250 ENOG4105C1J atp-dependent rna helicase BBB50_11255 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) BBB50_11260 ENOG4105BZU Histidine kinase BBB50_11275 ENOG4108YYD acetyltransferase BBB50_11280 ENOG4105XPQ lipid carrier protein BBB50_11285 ENOG4105BZU Histidine kinase BBB50_11290 ENOG4105CFP Peptidase U32 BBB50_11295 ENOG4106RZ4 Peptidase U32 BBB50_11310 ENOG4105RT1 May be involved in cell division (By similarity) BBB50_11315 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BBB50_11320 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BBB50_11325 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BBB50_11330 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) BBB50_11335 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BBB50_11340 ENOG4105CHV Transcription elongation factor NusA BBB50_11345 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) BBB50_11365 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BBB50_11370 ENOG4105EEI dihydropteroate synthase BBB50_11375 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BBB50_11380 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) BBB50_11385 ENOG4105HBR Rna-binding protein BBB50_11390 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BBB50_11395 ENOG4105FCK Membrane BBB50_11400 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase BBB50_11405 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BBB50_11410 ENOG4105DR5 peptidase BBB50_11425 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BBB50_11430 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BBB50_11440 ENOG4105IPI Membrane BBB50_11445 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) BBB50_11450 ENOG4105BZU Histidine kinase BBB50_11460 ENOG4107QRA Extracellular solute-binding protein, family 5 BBB50_11470 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BBB50_11475 ENOG4105C3U ABC transporter BBB50_11480 ENOG4108JQ7 (ABC) transporter BBB50_11490 ENOG4105RD7 BadF BadG BcrA BcrD BBB50_11495 ENOG4105E2D ec 3.2.1.52 BBB50_11500 ENOG4105E2V Glycosyltransferase 36 BBB50_11510 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BBB50_11530 ENOG4108YZA Nitrogen regulatory protein pii BBB50_11535 ENOG4105XTV UPF0231 protein BBB50_11540 ENOG4107QIJ Aconitate hydratase 2 BBB50_11545 ENOG4105D78 K07001 NTE family protein BBB50_11550 ENOG4105BZ4 penicillin-binding protein BBB50_11555 ENOG4105CQ7 ATP-dependent helicase BBB50_11565 ENOG4105PW4 Sugar fermentation stimulation protein homolog BBB50_11570 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters BBB50_11575 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) BBB50_11580 ENOG4105DJ0 Poly(A) Polymerase BBB50_11585 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BBB50_11590 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BBB50_11595 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) BBB50_11600 ENOG4105E3A (ABC) transporter BBB50_11605 ENOG4105DA5 (ABC) transporter BBB50_11610 ENOG4105CHH sulfate transporter BBB50_11615 ENOG41077A9 carbonic anhydrase BBB50_11620 ENOG4108UGV hypoxanthine phosphoribosyltransferase BBB50_11625 ENOG410630P Transcriptional regulator BBB50_11630 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BBB50_11635 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) BBB50_11640 ENOG41082RQ UPF0102 protein BBB50_11645 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) BBB50_11650 ENOG4105W4M Transport-associated protein BBB50_11655 ENOG4105KB2 stringent starvation protein b BBB50_11660 ENOG4107MKT Stringent starvation protein a BBB50_11665 ENOG4105EIX cytochrome c1 BBB50_11670 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BBB50_11675 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BBB50_11680 ENOG4108UJD 30S ribosomal protein S9 BBB50_11685 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BBB50_11695 ENOG4105D6Z AFG1 family ATPase BBB50_11705 ENOG4105C0H protease BBB50_11710 ENOG4105C0H protease BBB50_11715 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BBB50_11720 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) BBB50_11725 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) BBB50_11730 ENOG4105K5M 30s ribosomal protein S16 BBB50_11735 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY BBB50_11740 ENOG4106KVJ cytochrome C assembly protein BBB50_11745 ENOG4108JU6 CBS domain protein BBB50_11750 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) BBB50_11755 ENOG4105D9M gamma-glutamylcysteine synthetase BBB50_11765 ENOG4105W39 Membrane BBB50_11775 ENOG4105D9Q decarboxylase (Beta subunit) BBB50_11780 ENOG4107QSA Oxaloacetate decarboxylase BBB50_11830 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) BBB50_11835 ENOG4105CFH Aspartokinase BBB50_11840 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BBB50_11845 ENOG4105Y3E Modulates RecA activity (By similarity) BBB50_11850 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BBB50_11860 ENOG4108IJ6 ABC transporter BBB50_11865 ENOG4105ECW sulfate abc transporter BBB50_11870 ENOG4108I5D sulfate abc transporter BBB50_11875 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein BBB50_11880 ENOG4105C6T cysteine synthase BBB50_11885 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) BBB50_11890 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BBB50_11895 ENOG4108K5P (LipO)protein BBB50_11900 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) BBB50_11905 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) BBB50_11910 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) BBB50_11915 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BBB50_11920 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BBB50_11930 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BBB50_11935 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BBB50_11940 ENOG4107ZVW dihydroneopterin aldolase BBB50_11945 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BBB50_11955 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BBB50_11960 ENOG4105VCC 30S ribosomal protein S21 BBB50_11965 ENOG4105KTH gatB Yqey BBB50_11970 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BBB50_11975 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BBB50_11990 ENOG4105CH5 extracellular solute-binding protein, family 7 BBB50_11995 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BBB50_12000 ENOG410804X Transcriptional regulator BBB50_12005 ENOG4105CA9 Pyruvate kinase BBB50_12010 ENOG4105MPN Membrane BBB50_12015 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) BBB50_12020 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BBB50_12025 ENOG4105D64 Mechanosensitive ion channel BBB50_12035 ENOG4105D2N Aldolase BBB50_12040 ENOG4105BZA Phosphoglycerate kinase BBB50_12045 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BBB50_12050 ENOG4105D05 Receptor BBB50_12055 ENOG4108R4R Iron-regulated virulence regulatory protein BBB50_12060 ENOG4105CV1 Transketolase (EC 2.2.1.1) BBB50_12070 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BBB50_12075 ENOG4105GPY SprT protein BBB50_12080 ENOG4105RWS endonuclease I BBB50_12085 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BBB50_12090 ENOG4105D7Z glutathione synthase BBB50_12095 ENOG4108UJU UPF0301 protein BBB50_12100 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) BBB50_12105 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BBB50_12115 ENOG4105CZX twitching motility protein BBB50_12120 ENOG4105CZX twitching motility protein BBB50_12125 ENOG4105DFA alanine racemase domain protein BBB50_12130 ENOG4105II7 pyrroline-5-carboxylate reductase BBB50_12135 ENOG4108VIA integral membrane protein BBB50_12150 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BBB50_12155 ENOG4105CSA Coproporphyrinogen iii oxidase BBB50_12160 ENOG4105CSV Glutaminase BBB50_12165 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BBB50_12170 ENOG4105CEN a g-specific adenine glycosylase BBB50_12175 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) BBB50_12180 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division BBB50_12235 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) BBB50_12240 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) BBB50_12245 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) BBB50_12250 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) BBB50_12255 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BBB50_12260 ENOG4105NWN ApaG protein BBB50_12265 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BBB50_12275 ENOG4107XM3 UPF0442 protein BBB50_12280 ENOG4105DWK Membrane BBB50_12285 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BBB50_12290 ENOG4105K46 50S ribosomal protein l27 BBB50_12295 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BBB50_12300 ENOG4105EAH synthase BBB50_12305 ENOG4105D5Q Arginine ornithine antiporter BBB50_12310 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BBB50_12315 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) BBB50_12330 ENOG41081QV Universal stress protein BBB50_12350 ENOG4105CEU Arginine dihydrolase BBB50_12355 ENOG4105D1U peptidase U62 modulator of DNA gyrase BBB50_12365 ENOG4105QD6 exported protein BBB50_12370 ENOG4105C03 ribonuclease BBB50_12375 ENOG4108Z03 MAF-like protein BBB50_12380 ENOG4105VQ7 Rod shape-determining protein MreD BBB50_12385 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BBB50_12390 ENOG4105DFF Rod shape-determining protein mreb BBB50_12425 ENOG4105X0D Fimbrial protein BBB50_12435 ENOG4105D7Q type ii secretion system BBB50_12440 ENOG4107QHF type ii secretion system protein e BBB50_12455 ENOG4105E4G Type IV pilus BBB50_12475 ENOG41062P1 Diguanylate cyclase phosphodiesterase BBB50_12480 ENOG4108UUM single-stranded DNA-binding protein BBB50_12485 ENOG41086KC Transcriptional regulator BBB50_12490 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BBB50_12495 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BBB50_12505 ENOG4105C5R Aminotransferase BBB50_12510 ENOG4105CFH Aspartokinase BBB50_12515 ENOG4105C3R Methionine synthase BBB50_12520 ENOG4105EEQ Na H antiporter BBB50_12590 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) BBB50_12595 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BBB50_12600 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BBB50_12620 ENOG4105P4Z Phage shock protein G BBB50_12625 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BBB50_12630 ENOG4105MYN Zinc uptake regulation protein BBB50_12645 ENOG4107QP8 phosphohexose isomerase BBB50_12650 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme BBB50_12655 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BBB50_12660 ENOG4105CDU Replicative dna helicase BBB50_12670 ENOG4105K9Q Binds to the 23S rRNA (By similarity) BBB50_12675 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BBB50_12680 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) BBB50_12685 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) BBB50_12690 ENOG4108UQY Iron-storage protein BBB50_12695 ENOG4105W53 bacterioferritin-associated ferredoxin BBB50_12700 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BBB50_12705 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BBB50_12710 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BBB50_12715 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BBB50_12725 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) BBB50_12730 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) BBB50_12735 ENOG4105WWK YheO domain protein BBB50_12740 ENOG4108V1T peptidylprolyl cis-trans isomerase BBB50_12750 ENOG41069P5 Protein slyX homolog BBB50_12760 ENOG4105EPW hflc protein BBB50_12765 ENOG4107QJR hflk protein BBB50_12770 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BBB50_12775 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BBB50_12780 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BBB50_12785 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) BBB50_12790 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BBB50_12795 ENOG4105K8N protein family UPF0079, ATPase BBB50_12800 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BBB50_12845 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) BBB50_12850 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BBB50_12855 ENOG4105DJ4 phosphatidylserine decarboxylase BBB50_12860 ENOG4105C8P )-transporter BBB50_12870 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BBB50_12875 ENOG41063SB peptidase BBB50_12885 ENOG41062JF Transcriptional regulator BBB50_12890 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BBB50_12895 ENOG4105E09 nadh pyrophosphatase BBB50_12900 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor BBB50_12905 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BBB50_12910 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BBB50_12915 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BBB50_12920 ENOG4108VZM 50s ribosomal protein L10 BBB50_12925 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) BBB50_12930 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) BBB50_12935 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BBB50_12940 ENOG4105PM1 preprotein translocase subunit SecE BBB50_12945 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BBB50_12970 ENOG4105CS9 pantothenic acid kinase BBB50_12975 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase BBB50_12980 ENOG4105D4A Cell wall formation (By similarity) BBB50_12995 ENOG4105JIM Phosphatidylserine synthase BBB50_13035 ENOG4107QK7 reductase BBB50_13045 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) BBB50_13055 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BBB50_13060 ENOG4105K63 Thioredoxin BBB50_13065 ENOG4105C1J atp-dependent rna helicase BBB50_13070 ENOG4105C9X ppx gppa phosphatase BBB50_13075 ENOG4105BZU Histidine kinase BBB50_13080 ENOG4105D8G Major Facilitator superfamily BBB50_13100 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BBB50_13105 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BBB50_13110 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein BBB50_13115 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BBB50_13125 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BBB50_13130 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) BBB50_13135 ENOG4105DIQ Transcriptional regulator BBB50_13140 ENOG4105C01 Dihydroxy-acid dehydratase BBB50_13145 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family BBB50_13150 ENOG4105C6Z Gluconate BBB50_13155 ENOG4108UHU Aldolase BBB50_13160 ENOG4105E0K tonB-dependent siderophore receptor BBB50_13170 ENOG4105C8Q Methyl-accepting chemotaxis BBB50_13175 ENOG4105CXN decarboxylase BBB50_13180 ENOG4105D5Q Arginine ornithine antiporter BBB50_13185 ENOG4108M3R transcriptional activator CadC BBB50_13190 ENOG4105W1Y Transcriptional regulator BBB50_13195 ENOG4105DC1 bifunctional purine biosynthesis protein purh BBB50_13200 ENOG4105C12 Phosphoribosylglycinamide synthetase BBB50_13210 ENOG4105K70 DNA-binding protein BBB50_13225 ENOG4105DKQ ROK family BBB50_13230 ENOG4105EIP mannose-6-phosphate isomerase BBB50_13235 ENOG4105R2J Conserved Protein BBB50_13240 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase BBB50_13245 ENOG4108RG0 uracil-dna glycosylase BBB50_13250 ENOG4105CUY Mechanosensitive ion channel BBB50_13255 ENOG4105CY0 Metallo-Beta-Lactamase BBB50_13260 ENOG4105D3Q Sugar transferase BBB50_13290 ENOG410600T transposase BBB50_13295 ENOG4108UT6 Transferase hexapeptide repeat containing protein BBB50_13305 ENOG4108EKI Dehydrogenase BBB50_13310 ENOG4105CEY Amp-dependent synthetase and ligase BBB50_13320 ENOG4105EY8 ABC transporter BBB50_13335 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BBB50_13340 ENOG4105C0K Gdp-mannose 4,6-dehydratase BBB50_13345 ENOG4107QKV phosphomannomutase BBB50_13350 ENOG4105CJT Mannose-1-phosphate guanylyltransferase BBB50_13355 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) BBB50_13360 ENOG4107T94 Endo-14-beta-xylanase BBB50_13375 ENOG4105XA0 heptosyltransferase ii BBB50_13385 ENOG4108ST3 glycosyltransferase BBB50_13390 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase BBB50_13420 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) BBB50_13425 ENOG4105DKP glycosyl transferase, family 9 BBB50_13430 ENOG4106WTF Glycosyl transferase, family 2 BBB50_13435 ENOG4105M5K heptosyltransferase BBB50_13440 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BBB50_13445 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BBB50_13455 ENOG4105W0E 50S ribosomal protein L33 BBB50_13460 ENOG4105KDC 50s ribosomal protein l28 BBB50_13470 ENOG4105C8Q Methyl-accepting chemotaxis BBB50_13475 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BBB50_13480 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) BBB50_13485 ENOG4105D1S lipid A biosynthesis BBB50_13490 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase BBB50_13495 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BBB50_13500 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) BBB50_13505 ENOG4105DSJ YicC domain protein BBB50_13515 ENOG4105C5Y PTS System BBB50_13520 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BBB50_13530 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) BBB50_13535 ENOG4105S6R Iron-hydroxamate transporter permease subunit BBB50_13540 ENOG4105J76 Periplasmic binding protein BBB50_13545 ENOG4105E0A ABC, transporter BBB50_13550 ENOG4105E0K tonB-dependent siderophore receptor BBB50_13555 ENOG4105BZ1 (ABC) transporter BBB50_13570 ENOG4105C9U ATP-dependent DNA helicase RecQ BBB50_13575 ENOG4105FR1 rard protein BBB50_13585 ENOG4108DMH HTH_ARAC BBB50_13595 ENOG4105C4R Atp-dependent dna helicase BBB50_13600 ENOG4105DGW oligopeptidase A BBB50_13605 ENOG4105D6S protein involved in catabolism of external DNA BBB50_13610 ENOG4105DC8 reductase BBB50_13620 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BBB50_13625 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BBB50_13630 ENOG4105DEF Extracellular solute-binding protein, family 5 BBB50_13675 ENOG4105MPD Cytochrome BBB50_13680 ENOG4105C4R Atp-dependent dna helicase BBB50_13685 ENOG4105Y7M Transcriptional regulator, TetR family BBB50_13690 ENOG410624X efflux transporter, rnd family, mfp subunit BBB50_13695 ENOG4105BZS acriflavin resistance protein BBB50_13700 ENOG4105W0Z cytoplasmic protein BBB50_13705 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BBB50_13710 ENOG4105EMY transcriptional regulator BBB50_13785 ENOG4108RR8 protoporphyrinogen oxidase BBB50_13790 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) BBB50_13795 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BBB50_13800 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BBB50_13805 ENOG4105CHU acetyl-coa acetyltransferase BBB50_13810 ENOG4105F52 Transcriptional regulator BBB50_13815 ENOG4105CZQ inner membrane transport protein YdhC BBB50_13825 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BBB50_13830 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BBB50_13835 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BBB50_13840 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BBB50_13845 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BBB50_13850 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BBB50_13855 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BBB50_13860 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) BBB50_13865 ENOG410684E atp synthase BBB50_13870 ENOG4105FA0 parb-like partition protein BBB50_13875 ENOG4107QJE Chromosome Partitioning Protein BBB50_13880 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) BBB50_13885 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BBB50_13895 ENOG4105QTB Flavodoxin BBB50_13900 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BBB50_13905 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BBB50_13910 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) BBB50_13915 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) BBB50_13930 ENOG4105E5Q amino acid AbC transporter BBB50_13935 ENOG4105EAB amino acid AbC transporter BBB50_13960 ENOG4105CDY transcriptional regulatory protein BBB50_13965 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BBB50_13970 ENOG4105C8Q Methyl-accepting chemotaxis BBB50_13980 ENOG4108YYI Protein of unknown function (DUF2810) BBB50_13985 ENOG41061ZR Transcriptional regulator BBB50_13990 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) BBB50_13995 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) BBB50_14000 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) BBB50_14005 ENOG4108WC9 type VI secretion system effector, hcp1 family BBB50_14010 ENOG4105CS6 Rhs element vgr protein BBB50_14035 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BBB50_14045 ENOG4105C8P )-transporter BBB50_14050 ENOG4108Q67 UPF0319 protein BBB50_14075 ENOG4105C8Q Methyl-accepting chemotaxis BBB50_14095 ENOG4105EYK Phosphatidylglycerophosphatase B BBB50_14100 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) BBB50_14125 ENOG4105D6U Sodium Glutamate Symporter BBB50_14130 ENOG4105YE1 PilZ domain BBB50_14145 ENOG4105EFX secretion protein, HlyD family BBB50_14150 ENOG4105KK7 inner membrane protein YiaW BBB50_14155 ENOG4106TD9 Diguanylate cyclase BBB50_14170 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BBB50_14180 ENOG4107SEY Conserved Protein BBB50_14190 ENOG4105CVP deoxyribo-dipyrimidine photolyase BBB50_14195 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BBB50_14210 ENOG4105C1J atp-dependent rna helicase BBB50_14215 ENOG4105CUG Oligopeptidase b BBB50_14245 ENOG4105CVA phosphate BBB50_14250 ENOG4105C8U phosphate abc transporter BBB50_14255 ENOG4105E2Z phosphate ABC transporter (Permease BBB50_14260 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BBB50_14265 ENOG4105BZU Histidine kinase BBB50_14275 ENOG4105DWD nucleoside recognition domain protein BBB50_14280 ENOG4105CHH sulfate transporter BBB50_14290 ENOG4105DR5 peptidase BBB50_14295 ENOG4105BZU Histidine kinase BBB50_14300 ENOG4105EQ2 LysR family Transcriptional regulator BBB50_14305 ENOG4105E5M Multidrug resistance protein D BBB50_14310 ENOG4108Z4X TRANSCRIPTIONal BBB50_14330 ENOG4105CK2 sodium dicarboxylate symporter BBB50_14375 ENOG4107RH7 Nicotinate phosphoribosyltransferase BBB50_14380 ENOG4105D9R oxidoreductase BBB50_14390 ENOG4105BZU Histidine kinase BBB50_14395 ENOG4107VXZ Hydrolase BBB50_14405 ENOG4105D3G Pseudouridine synthase BBB50_14465 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BBB50_14470 ENOG4108JUB Transcriptional regulator BBB50_14500 ENOG4105CS6 Rhs element vgr protein BBB50_14520 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) BBB50_14525 ENOG4105C2J ABC transporter BBB50_14530 ENOG4105CNN ABC, transporter BBB50_14535 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BBB50_14540 ENOG4108RVA ribokinase BBB50_14545 ENOG4105ETE Transcriptional regulator (LacI family BBB50_14550 ENOG4106Z1T Nicotinamide Mononucleotide Transporter BBB50_14555 ENOG4108I5U Uridine phosphorylase BBB50_14565 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase BBB50_14570 ENOG4105CXY transporter BBB50_14585 ENOG4105CQZ Histidine kinase BBB50_14590 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BBB50_14610 ENOG4105D5U fad dependent oxidoreductase BBB50_14620 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BBB50_14630 ENOG4105KJM monovalent cation h antiporter subunit g BBB50_14635 ENOG41080TA Multiple resistance and ph regulation protein f BBB50_14640 ENOG4105SC1 monovalent cation H antiporter subunit E BBB50_14645 ENOG4108JPZ Monovalent cation H antiporter subunit D BBB50_14650 ENOG4105MKQ Monovalent cation H antiporter subunit C BBB50_14655 ENOG4105D65 subunit l BBB50_14665 ENOG4105Q9Y Universal stress protein BBB50_14670 ENOG4105CIC tryptophan-specific transport protein BBB50_14675 ENOG4105C0F tryptophanase EC 4.1.99.1 BBB50_14685 ENOG4105VRT cytoplasmic protein BBB50_14695 ENOG4105BZU Histidine kinase BBB50_14700 ENOG4105VEQ Cold shock protein BBB50_14735 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BBB50_14740 ENOG41069D7 Methyl-accepting chemotaxis BBB50_14755 ENOG4105D9N nucleoside BBB50_14760 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BBB50_14770 ENOG4108JUA Transcriptional regulator BBB50_14775 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BBB50_14780 ENOG4105VEQ Cold shock protein BBB50_14800 ENOG4108UNF response regulator BBB50_14810 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) BBB50_14815 ENOG4105C5I Dehydrogenase BBB50_14840 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BBB50_14865 ENOG4108RS6 transposase BBB50_14870 ENOG4105C1J atp-dependent rna helicase BBB50_14875 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BBB50_14880 ENOG4107RA1 nh(3)-dependent nad( ) synthetase BBB50_14885 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BBB50_14895 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BBB50_14900 ENOG4105BZU Histidine kinase BBB50_14910 ENOG4107S6Z Na H antiporter BBB50_14915 ENOG4105E5M Multidrug resistance protein D BBB50_14930 ENOG4105BZU Histidine kinase BBB50_14935 ENOG4105KUU lipolytic protein G-D-S-L family BBB50_14940 ENOG4106M3D hemolysin BBB50_14945 ENOG4108N3W hemolysin secretion protein BBB50_14950 ENOG4107IFA Lipase (EC 3.1.1.3) BBB50_14960 ENOG4107G87 m6 family metalloprotease domain protein BBB50_14980 ENOG4105DHS permease protein BBB50_14985 ENOG4105CM4 permease protein BBB50_14990 ENOG4108IPW abc transporter atp-binding protein BBB50_15010 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BBB50_15030 ENOG4105ETX regulatoR BBB50_15040 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase BBB50_15050 ENOG410667J hydrolase BBB50_15080 ENOG4105DS1 cytochrome b561 BBB50_15110 ENOG4105XJC Two component transcriptional regulator (Winged helix family BBB50_15115 ENOG4105BZU Histidine kinase BBB50_15140 ENOG4107QVI Methyltransferase, type 11 BBB50_15155 ENOG4105C2C drug resistance transporter, Bcr CflA BBB50_15160 ENOG4108RS6 transposase BBB50_15165 ENOG4105C8Q Methyl-accepting chemotaxis BBB50_15175 ENOG4105DZ1 carboxypeptidase BBB50_15190 ENOG4108UHE carbonic anhydrase BBB50_15195 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BBB50_15200 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BBB50_15205 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BBB50_15215 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BBB50_15225 ENOG4105F2I Transposase BBB50_15250 ENOG4105C22 threonyL-tRNA synthetase BBB50_15255 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BBB50_15260 ENOG41082NX 50s ribosomal protein l35 BBB50_15265 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BBB50_15275 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase BBB50_15290 ENOG41080ET plasmid maintenance system killer protein BBB50_15295 ENOG4105VDM plasmid maintenance system antidote protein, xre family BBB50_15340 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BBB50_15360 ENOG4105YGK Pfam:UPF0157 BBB50_15365 ENOG4105YGK Pfam:UPF0157 BBB50_15380 ENOG4105QNF Outer membrane lipoprotein BBB50_15390 ENOG4105VXN addiction module toxin, RelE StbE family BBB50_15450 ENOG4105KD7 acetyltransferase BBB50_15525 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase BBB50_15550 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase BBB50_15590 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BBB50_15625 ENOG4105EST Metal Dependent Phosphohydrolase BBB50_15670 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BBB50_15705 ENOG4105QNF Outer membrane lipoprotein BBB50_15770 ENOG41080ET plasmid maintenance system killer protein BBB50_15775 ENOG4105VDM plasmid maintenance system antidote protein, xre family BBB50_15780 ENOG4108S58 Phenazine biosynthesis protein PhzF BBB50_15810 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase BBB50_15830 ENOG4105QNF Outer membrane lipoprotein BBB50_15905 ENOG4105D9U N-acetyltransferase BBB50_15985 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BBB50_16005 ENOG4105QNF Outer membrane lipoprotein BBB50_16065 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein BBB50_16100 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase BBB50_16125 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system BBB50_16130 ENOG4105W08 virulence gene repressor rsal BBB50_16145 ENOG4105F2I Transposase BBB50_16165 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase BBB50_16270 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase BBB50_16290 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BBB50_16295 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) BBB50_16300 ENOG4105CGF Aromatic amino acid aminotransferase BBB50_16305 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) BBB50_16310 ENOG4105DM4 PTS System BBB50_16315 ENOG4105DE4 1-phosphofructokinase BBB50_16320 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein BBB50_16325 ENOG4107B7Y DNA-binding transcriptional regulator FruR BBB50_16330 ENOG4107RFY SbcCD D subunit BBB50_16335 ENOG4105EYH Exonuclease BBB50_16340 ENOG4108MGY Histidine kinase BBB50_16345 ENOG4107KBT 8-Amino-7-oxononanoate synthase BBB50_16355 ENOG4105CMQ Chloride channel BBB50_16360 ENOG4105CKI cobalamin synthesis protein BBB50_16365 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BBB50_16370 ENOG4105DFH Transport of potassium into the cell (By similarity) BBB50_16375 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) BBB50_16380 ENOG4105C08 Histidine kinase BBB50_16385 ENOG4105EEX Two component transcriptional regulator (Winged helix family BBB50_16390 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) BBB50_16395 ENOG4108RHM integral membrane protein BBB50_16405 ENOG4105EPM Diguanylate phosphodiesterase BBB50_16415 ENOG4105DS1 cytochrome b561 BBB50_16425 ENOG4105TMB Formate nitrite transporter BBB50_16430 ENOG4105DUM transcriptional regulator, lysR family BBB50_16435 ENOG4108UQ5 membrane protein YcdZ BBB50_16440 ENOG4105CPB ATP-dependent endonuclease of the OLD family BBB50_16445 ENOG4105CGH 5'-nucleotidase BBB50_16450 ENOG4105DU1 integral membrane protein, terc BBB50_16460 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BBB50_16495 ENOG4105BZU Histidine kinase BBB50_16505 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BBB50_16515 ENOG4105BZU Histidine kinase BBB50_16530 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) BBB50_16535 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) BBB50_16545 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BBB50_16565 ENOG4108ZJT translation initiation factor, Sui1 BBB50_16575 ENOG4105CPF Cell wall formation (By similarity) BBB50_16585 ENOG4105CD5 CoA-binding domain protein BBB50_16590 ENOG4105CWB LysR family transcriptional Regulator BBB50_16610 ENOG4105KA0 thioesterase Superfamily protein BBB50_16630 ENOG4105CYM Glutathione S-transferase BBB50_16645 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BBB50_16650 ENOG4108JQ5 ABC transporter BBB50_16655 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component BBB50_16660 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component BBB50_16665 ENOG4105E43 Extracellular solute-binding protein, family 5 BBB50_16690 ENOG4105DUX Transporter BBB50_16705 ENOG4107RCV ABC transporter, permease BBB50_16720 ENOG4107STF Involved in phosphonate degradation (By similarity) BBB50_16725 ENOG4108JPW Aminotransferase BBB50_16730 ENOG4108KAZ Involved in phosphonate degradation (By similarity) BBB50_16735 ENOG4105NXH GreA GreB family elongation factor BBB50_16740 ENOG4105PAD Hydrolase BBB50_16750 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain BBB50_16755 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) BBB50_16760 ENOG4105CKU formyltetrahydrofolate synthetase BBB50_16765 ENOG4105E0X reductase BBB50_16770 ENOG4105EUJ GTP cyclohydrolase i BBB50_16775 ENOG4105CVM Molybdenum cofactor synthesis domain protein BBB50_16780 ENOG4105D06 uba thif-type nad fad binding protein BBB50_16790 ENOG4105KHC sulfurtransferase BBB50_16795 ENOG4107RHR regulatoR BBB50_16805 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BBB50_16810 ENOG4105CV1 Transketolase (EC 2.2.1.1) BBB50_16835 ENOG4108M3J Dehydrogenase BBB50_16850 ENOG4105RA2 Membrane BBB50_16860 ENOG4105ETT transcriptional Regulator, LysR family BBB50_16865 ENOG41067V3 Antibiotic biosynthesis monooxygenase BBB50_16870 ENOG4108RCM Nitroreductase BBB50_16895 ENOG41080HT Transcriptional regulator, arsr family BBB50_16905 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BBB50_16950 ENOG4105C5Y PTS System BBB50_16955 ENOG4105ETE Transcriptional regulator (LacI family BBB50_16960 ENOG4107R3K hydrolase BBB50_16965 ENOG4105D7K pfkb domain protein BBB50_16970 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BBB50_16975 ENOG4108NVR Methyl-accepting chemotaxis BBB50_16980 ENOG4108ZG0 Ompa motb domain protein BBB50_16985 ENOG4108V1T peptidylprolyl cis-trans isomerase BBB50_16990 ENOG4107VXZ Hydrolase BBB50_16995 ENOG4108N3W hemolysin secretion protein BBB50_17005 ENOG4105CEE C4-dicarboxylate transporter BBB50_17010 ENOG4105EJQ L-serine dehydratase BBB50_17035 ENOG4105ETE Transcriptional regulator (LacI family BBB50_17040 ENOG4105WH1 Two component transcriptional regulator luxr family BBB50_17045 ENOG4105BZU Histidine kinase BBB50_17060 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BBB50_17080 ENOG4105DHT Metal Dependent Phosphohydrolase BBB50_17085 ENOG4108KX4 response regulator BBB50_17090 ENOG4105BZU Histidine kinase BBB50_17095 ENOG4105CXY transporter BBB50_17100 ENOG4105C4Y ABC transporter BBB50_17105 ENOG4107RCV ABC transporter, permease BBB50_17110 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BBB50_17115 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class BBB50_17125 ENOG4105CHU acetyl-coa acetyltransferase BBB50_17135 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BBB50_17140 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BBB50_17155 ENOG4105BZU Histidine kinase BBB50_17160 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BBB50_17170 ENOG4108I6A alcohol dehydrogenase BBB50_17180 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta BBB50_17190 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC BBB50_17195 ENOG4105CXY transporter BBB50_17200 ENOG4105CA9 Pyruvate kinase BBB50_17205 ENOG4105BZU Histidine kinase BBB50_17210 ENOG4108SV3 Tmao reductase system periplasmic protein tort BBB50_17215 ENOG4108Z5K methylglyoxal synthase BBB50_17220 ENOG4108RWI nicotinamidase BBB50_17225 ENOG41080IJ Diacylglycerol kinase BBB50_17240 ENOG41088T4 Helicase IV BBB50_17245 ENOG4105EM2 membrane BBB50_17275 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) BBB50_17280 ENOG4105E0C molybdate abc transporter BBB50_17285 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BBB50_17290 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) BBB50_17335 ENOG4105BZU Histidine kinase BBB50_17340 ENOG4108QGH periplasmic BBB50_17350 ENOG41082IR Excinuclease ABC C subunit domain protein BBB50_17385 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BBB50_17395 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A BBB50_17400 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B BBB50_17405 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BBB50_17410 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BBB50_17415 ENOG4105K63 Thioredoxin BBB50_17445 ENOG4105DUM transcriptional regulator, lysR family BBB50_17450 ENOG4105DMR ABC, transporter BBB50_17455 ENOG4105GBT ABC transporter BBB50_17460 ENOG4106PMH Extracellular solute-binding protein family 3 BBB50_17465 ENOG4105E5Z arginine transporter ATP-binding subunit BBB50_17475 ENOG4105EV2 VWA domain protein interacting with AAA ATPase BBB50_17485 ENOG4108YZ4 nudix hydrolase BBB50_17490 ENOG4105C5W Aldolase BBB50_17495 ENOG4106RE7 Cytochrome BBB50_17500 ENOG4108IG5 Transcriptional regulator BBB50_17505 ENOG4105C1J atp-dependent rna helicase BBB50_17510 ENOG4108ZYK Acyl carrier protein phosphodiesterase BBB50_17520 ENOG4105E0U tyrosine-specific transport protein BBB50_17555 ENOG4105C5W Aldolase BBB50_17560 ENOG4106RE7 Cytochrome BBB50_17565 ENOG4108IG5 Transcriptional regulator BBB50_17570 ENOG4105C1J atp-dependent rna helicase BBB50_17575 ENOG4108ZYK Acyl carrier protein phosphodiesterase BBB50_17585 ENOG4105E0U tyrosine-specific transport protein BBB50_17590 ENOG4108N3W hemolysin secretion protein BBB50_17595 ENOG4105CMR udp-glucose 4-epimerase BBB50_17605 ENOG4105E7W lamb ycsf family protein BBB50_17615 ENOG4107R7A Allophanate hydrolase subunit 2 BBB50_17625 ENOG4105C6Y Udp-glucose 6-dehydrogenase BBB50_17630 ENOG4105CV6 ABC transporter, permease BBB50_17635 ENOG4108I0Y (ABC) transporter BBB50_17645 ENOG4105RKW reductase (By BBB50_17665 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BBB50_17710 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BBB50_17725 ENOG4107RE1 Inosine-guanosine kinase BBB50_17730 ENOG4105E0M Sulfatase BBB50_17740 ENOG4105C1J atp-dependent rna helicase BBB50_17745 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) BBB50_17755 ENOG4105CVA phosphate BBB50_17765 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein BBB50_17770 ENOG4108M1A Chitin-binding protein BBB50_17775 ENOG4105D4Y metalloprotease BBB50_17785 ENOG4105CYW agmatinase BBB50_17790 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) BBB50_17800 ENOG4105CJW magnesium transporter BBB50_17805 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BBB50_17810 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BBB50_17820 ENOG4105CZK Aspartate kinase BBB50_17825 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) BBB50_17830 ENOG4108JPW Aminotransferase BBB50_17835 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase BBB50_17840 ENOG41090A4 Pterin carbinolamine dehydratase BBB50_17845 ENOG4105MIR Phenylalanine 4-monooxygenase BBB50_17850 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BBB50_17865 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BBB50_17870 ENOG4105EGI Transcriptional regulator BBB50_17885 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) BBB50_17890 ENOG4105C37 (CBS) domain BBB50_17895 ENOG4108UKZ OsmC family BBB50_17900 ENOG4107YWA deoxycytidylate deaminase BBB50_17930 ENOG4106TD9 Diguanylate cyclase BBB50_17940 ENOG4108VAC response regulator BBB50_17945 ENOG4108HRK Histidine kinase BBB50_17960 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BBB50_17965 ENOG4105C19 ABC transporter BBB50_17980 ENOG4107RGM aldo keto reductase BBB50_17985 ENOG4107T9C Alpha amylase catalytic region BBB50_18000 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation BBB50_18005 ENOG4108M0H Extracellular lipase BBB50_18010 ENOG4107SDU Methyl-accepting chemotaxis BBB50_18015 ENOG4105D4Y metalloprotease BBB50_18035 ENOG41061WM D-Alanyl-D-Alanine BBB50_18040 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BBB50_18045 ENOG4105C4M (Ubiquinol oxidase) subunit I BBB50_18050 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BBB50_18060 ENOG4105BZC d-serine deaminase BBB50_18065 ENOG4105W8I Transcriptional regulator BBB50_18110 ENOG4105CPQ Dehydrogenase BBB50_18115 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BBB50_18120 ENOG4108IQK o-acetylhomoserine BBB50_18125 ENOG4105EXG Transcriptional regulator BBB50_18130 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BBB50_18155 ENOG4105DHT Metal Dependent Phosphohydrolase BBB50_18160 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BBB50_18165 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) BBB50_18170 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BBB50_18195 ENOG4105BZW Glycerate kinase BBB50_18200 ENOG4105C6Z Gluconate BBB50_18205 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR BBB50_18210 ENOG4108NVR Methyl-accepting chemotaxis BBB50_18215 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related BBB50_18220 ENOG41090JE Utilization Protein BBB50_18225 ENOG4105D4P Coproporphyrinogen iii oxidase BBB50_18230 ENOG4105WQ5 TonB family BBB50_18235 ENOG41090AP transport protein BBB50_18240 ENOG4106GFD transport protein BBB50_18245 ENOG4107R4I Periplasmic binding protein BBB50_18250 ENOG4105EHG Permease protein BBB50_18255 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) BBB50_18285 ENOG4105C8Q Methyl-accepting chemotaxis BBB50_18290 ENOG4105QVC MOSC domain-containing protein BBB50_18290 ENOG4105QVC MOSC domain-containing protein BBB50_18295 ENOG4105EKE dihydroorotase BBB50_18305 ENOG4105KAF membrAne BBB50_18315 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) BBB50_18320 ENOG4105CKW Inner membrane protein yedI BBB50_18325 ENOG4108ESY Metal dependent phosphohydrolase BBB50_18330 ENOG4105VEQ Cold shock protein BBB50_18345 ENOG4105EQD regulatoR BBB50_18355 ENOG4105BZU Histidine kinase BBB50_18360 ENOG4105E98 transcriptional regulator DeoR family BBB50_18375 ENOG4105EG2 ABC transporter, permease BBB50_18380 ENOG4105D56 permease protein BBB50_18385 ENOG4107FKK extracellular solute-binding protein family 1 BBB50_18390 ENOG4108IJ9 (ABC) transporter BBB50_18395 ENOG4108HK0 -acetyltransferase BBB50_18410 ENOG4105K8R UPF0145 protein BBB50_18415 ENOG41086KC Transcriptional regulator BBB50_18420 ENOG4105KQ5 peptidylprolyl cis-trans isomerase BBB50_18425 ENOG4107R88 Chemotaxis protein (CheV) BBB50_18430 ENOG4105K56 Transcriptional regulator BBB50_18435 ENOG4106TD9 Diguanylate cyclase BBB50_18455 ENOG4105BZU Histidine kinase BBB50_18475 ENOG4105ETT transcriptional Regulator, LysR family BBB50_18480 ENOG4108K0B C-di-gmp phosphodiesterase BBB50_18490 ENOG4105EUB pirin domain protein BBB50_18495 ENOG4105NBK UPF0345 protein BBB50_18505 ENOG4105E5W Transporter BBB50_18515 ENOG4105C8Q Methyl-accepting chemotaxis BBB50_18520 ENOG4105DAN ATP-dependent protease BBB50_18530 ENOG4108JQ5 ABC transporter BBB50_18535 ENOG4105E89 ABC transporter BBB50_18540 ENOG4105C8Q Methyl-accepting chemotaxis BBB50_18550 ENOG4105CC0 LysR family Transcriptional regulator BBB50_18555 ENOG4105DAA L-lactate BBB50_18560 ENOG4105DMF Dehydrogenase BBB50_18570 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BBB50_18580 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor BBB50_18590 ENOG4105C1J atp-dependent rna helicase BBB50_18595 ENOG4105CR8 Transcriptional regulator BBB50_18605 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BBB50_18615 ENOG4105BZ1 (ABC) transporter BBB50_18625 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BBB50_18660 ENOG4105K56 Transcriptional regulator BBB50_18665 ENOG4108ZHJ Organic hydroperoxide resistance protein BBB50_18675 ENOG4108SXK Transporter Drug Metabolite Exporter family BBB50_18680 ENOG4105VW4 glutaredoxin 3 BBB50_18685 ENOG4108P2H Inner membrane protein YjiG BBB50_18690 ENOG41074DU domain protein BBB50_18695 ENOG4105DN9 Na H antiporter BBB50_18705 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BBB50_18710 ENOG4105D03 DNA-3-methyladenine glycosylase II BBB50_18715 ENOG4108VGI doxx family BBB50_18740 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BBB50_18750 ENOG4107W52 maltose operon periplasmic protein BBB50_18755 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) BBB50_18770 ENOG4108N3W hemolysin secretion protein BBB50_18785 ENOG4105C8Q Methyl-accepting chemotaxis BBB50_18795 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) BBB50_18800 ENOG4105CDA abc transporter atp-binding protein BBB50_18810 ENOG4106TNF Periplasmic binding protein BBB50_18815 ENOG4105EZ7 amino acid ABC transporter BBB50_18820 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain BBB50_18830 ENOG4105DR5 peptidase BBB50_18840 ENOG4105CTS PTS system mannitol-specific BBB50_18845 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase BBB50_18850 ENOG4105E61 Mannitol repressor protein BBB50_18855 ENOG4105EP9 oxidoreductase BBB50_18885 ENOG4108RYK Nad-dependent epimerase dehydratase BBB50_18890 ENOG4105JQN Transcriptional regulator BBB50_18895 ENOG41069D7 Methyl-accepting chemotaxis BBB50_18900 ENOG4105EMU Dehydrogenase BBB50_18905 ENOG4105JQN Transcriptional regulator BBB50_18915 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BBB50_18920 ENOG4105D5Q Arginine ornithine antiporter BBB50_18925 ENOG4105CXN decarboxylase BBB50_18935 ENOG4107RGH Aldehyde dehydrogenase BBB50_18940 ENOG4105EW9 transcriptional regulator AsnC family BBB50_18945 ENOG4105C8Q Methyl-accepting chemotaxis BBB50_18955 ENOG4105CK7 Sodium proline symporter BBB50_18965 ENOG4105C26 Dehydrogenase BBB50_18980 ENOG4105E6M Sulphatase-modifying factor protein BBB50_18990 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) BBB50_18995 ENOG4107QZV Type I secretion membrane fusion protein BBB50_19010 ENOG4108JJA ABC, transporter BBB50_19020 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BBB50_19030 ENOG4105C8Q Methyl-accepting chemotaxis BBB50_19035 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) BBB50_19040 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) BBB50_19045 ENOG4105BZU Histidine kinase BBB50_19050 ENOG4105C8Q Methyl-accepting chemotaxis BBB50_19055 ENOG4108V3W Chemotaxis protein, CheW BBB50_19060 ENOG4108V3W Chemotaxis protein, CheW BBB50_19065 ENOG4105CBS Chea signal transduction histidine kinase BBB50_19070 ENOG4108VYJ response regulator receiver protein BBB50_19085 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BBB50_19090 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BBB50_19095 ENOG4108JQ6 ABC transporter BBB50_19100 ENOG4105DIJ Phosphoethanolamine transferase BBB50_19105 ENOG4105DHQ Histidine kinase BBB50_19110 ENOG4105XJC Two component transcriptional regulator (Winged helix family BBB50_19140 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) BBB50_19145 ENOG4107RUE extracellular solute-binding protein family 1 BBB50_19150 ENOG4106RMF ParB family