locus-tag	class	description
BBB50_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BBB50_00010	COG0592	DNA-directed DNA polymerase activity
BBB50_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BBB50_00020	COG0187	DNA topoisomerase II activity
BBB50_00035	COG0071	Belongs to the small heat shock protein (HSP20) family
BBB50_00040	COG3977	Valine--pyruvate aminotransferase
BBB50_00045	COG0751	glycine-tRNA ligase activity
BBB50_00050	COG0752	glycyl-tRNA synthetase alpha subunit
BBB50_00055	COG2119	membrane
BBB50_00065	COG0425	Belongs to the sulfur carrier protein TusA family
BBB50_00075	COG0604	alcohol dehydrogenase
BBB50_00085	COG0129	dihydroxy-acid dehydratase activity
BBB50_00090	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BBB50_00105	COG0606	chelatase, subunit chli
BBB50_00110	COG0204	Acyl-transferase
BBB50_00115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BBB50_00120	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BBB50_00130	COG3084	Protein conserved in bacteria
BBB50_00140	COG4326	sporulation control protein
BBB50_00145	COG1272	protein, Hemolysin III
BBB50_00155	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BBB50_00160	COG0569	domain protein
BBB50_00165	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BBB50_00165	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BBB50_00170	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BBB50_00175	COG0242	peptide deformylase activity
BBB50_00180	COG1652	LysM domain
BBB50_00185	COG0758	DNA mediated transformation
BBB50_00190	COG2922	Belongs to the Smg family
BBB50_00195	COG0551	DNA topoisomerase type I activity
BBB50_00200	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BBB50_00205	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BBB50_00210	COG0009	L-threonylcarbamoyladenylate synthase
BBB50_00215	COG0408	coproporphyrinogen oxidase activity
BBB50_00220	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BBB50_00230	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BBB50_00275	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BBB50_00280	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BBB50_00290	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BBB50_00295	COG2104	thiamine diphosphate biosynthetic process
BBB50_00300	COG2022	thiamine diphosphate biosynthetic process
BBB50_00305	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BBB50_00310	COG0006	proline dipeptidase activity
BBB50_00310	COG0006	proline dipeptidase activity
BBB50_00330	COG1522	sequence-specific DNA binding
BBB50_00335	COG5001	Diguanylate cyclase
BBB50_00335	COG5002	protein histidine kinase activity
BBB50_00340	COG0742	ribosomal rna small subunit methyltransferase
BBB50_00350	COG0697	spore germination
BBB50_00355	COG0589	response to stress
BBB50_00365	COG1528	Iron-storage protein
BBB50_00375	COG2081	HI0933 family
BBB50_00385	COG1322	Protein conserved in bacteria
BBB50_00390	COG2226	methyltransferase
BBB50_00400	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BBB50_00405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BBB50_00410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BBB50_00415	COG0805	protein transport
BBB50_00420	COG1858	cytochrome C peroxidase
BBB50_00425	COG0534	Mate efflux family protein
BBB50_00435	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BBB50_00440	COG2937	Belongs to the GPAT DAPAT family
BBB50_00445	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BBB50_00450	COG3161	chorismate lyase activity
BBB50_00460	COG1580	Controls the rotational direction of flagella during chemotaxis
BBB50_00465	COG0840	transmembrane signaling receptor activity
BBB50_00475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BBB50_00485	COG0084	hydrolase, TatD family'
BBB50_00500	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BBB50_00500	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BBB50_00505	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BBB50_00520	COG3078	GTPase activator activity
BBB50_00530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BBB50_00535	COG3071	HemY protein
BBB50_00540	COG2959	enzyme of heme biosynthesis
BBB50_00545	COG1587	Uroporphyrinogen-III synthase
BBB50_00550	COG0181	hydroxymethylbilane synthase activity
BBB50_00560	COG3072	Adenylate cyclase
BBB50_00565	COG1965	Belongs to the frataxin family
BBB50_00575	COG0019	diaminopimelate decarboxylase activity
BBB50_00580	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BBB50_00590	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BBB50_00595	COG1011	Hydrolase
BBB50_00600	COG3287	FIST C domain
BBB50_00600	COG2199	diguanylate cyclase activity
BBB50_00600	COG2200	EAL domain
BBB50_00620	COG0561	phosphatase activity
BBB50_00625	COG2267	carboxylic ester hydrolase activity
BBB50_00630	COG1280	lysine exporter protein (LysE YggA)
BBB50_00635	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BBB50_00640	COG0783	Belongs to the Dps family
BBB50_00675	COG0742	ribosomal rna small subunit methyltransferase
BBB50_00680	COG0552	protein localization to endoplasmic reticulum
BBB50_00685	COG2884	Cell division ATP-binding protein ftsE
BBB50_00690	COG2177	Part of the ABC transporter FtsEX involved in
BBB50_00695	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BBB50_00700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BBB50_00715	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BBB50_00720	COG4206	TonB-dependent receptor
BBB50_00725	COG1404	Belongs to the peptidase S8 family
BBB50_00730	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BBB50_00805	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BBB50_00810	COG3300	MHYT domain
BBB50_00810	COG5001	Diguanylate cyclase
BBB50_00820	COG3852	Histidine kinase
BBB50_00830	COG0174	glutamine synthetase
BBB50_00855	COG1490	D-aminoacyl-tRNA deacylase activity
BBB50_00860	COG0456	acetyltransferase
BBB50_00870	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BBB50_00875	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BBB50_00880	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BBB50_00885	COG3031	protein transport across the cell outer membrane
BBB50_00895	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BBB50_00900	COG1459	type II secretion system
BBB50_00905	COG2165	general secretion pathway protein
BBB50_00910	COG2165	general secretion pathway protein
BBB50_00915	COG2165	general secretion pathway protein
BBB50_00920	COG4795	General secretion pathway protein
BBB50_00925	COG3156	type II secretion system protein K
BBB50_00930	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
BBB50_00935	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
BBB50_00945	COG1218	3'(2'),5'-bisphosphate nucleotidase
BBB50_00950	COG0494	nUDIX hydrolase
BBB50_00955	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BBB50_00955	COG0316	Belongs to the HesB IscA family
BBB50_00960	COG1040	competence protein
BBB50_00965	COG0596	Alpha beta hydrolase
BBB50_00975	COG2183	response to ionizing radiation
BBB50_00980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BBB50_00985	COG0745	RESPONSE REGULATOR receiver
BBB50_00995	COG2233	PERMEase
BBB50_01000	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BBB50_01005	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BBB50_01010	COG1758	RNA polymerase activity
BBB50_01015	COG0194	GDP metabolic process
BBB50_01020	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BBB50_01025	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BBB50_01035	COG3263	regulation of cellular component size
BBB50_01045	COG4232	protein-disulfide reductase activity
BBB50_01060	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BBB50_01065	COG1027	Aspartate ammonia-lyase
BBB50_01070	COG3706	GGDEF domain
BBB50_01075	COG3030	protein affecting phage T7 exclusion by the F plasmid
BBB50_01080	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BBB50_01090	COG2205	protein histidine kinase activity
BBB50_01095	COG0745	RESPONSE REGULATOR receiver
BBB50_01105	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BBB50_01110	COG0205	6-phosphofructokinase activity
BBB50_01115	COG1494	fructose-1,6-bisphosphatase
BBB50_01120	COG3074	FtsZ-dependent cytokinesis
BBB50_01125	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BBB50_01130	COG0460	homoserine dehydrogenase
BBB50_01130	COG0527	aspartate kinase activity
BBB50_01135	COG0626	cystathionine gamma-synthase activity
BBB50_01140	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
BBB50_01145	COG0281	malic enzyme
BBB50_01150	COG0254	rRNA binding
BBB50_01155	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BBB50_01160	COG1609	Transcriptional regulator
BBB50_01165	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BBB50_01170	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BBB50_01175	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BBB50_01180	COG1575	Belongs to the MenA family. Type 1 subfamily
BBB50_01185	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BBB50_01195	COG0149	triose-phosphate isomerase activity
BBB50_01220	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BBB50_01225	COG0459	protein refolding
BBB50_01235	COG1509	lysine 2,3-aminomutase activity
BBB50_01240	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BBB50_01245	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
BBB50_01250	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
BBB50_01255	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BBB50_01260	COG1053	succinate dehydrogenase
BBB50_01265	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BBB50_01270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BBB50_01275	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BBB50_01280	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BBB50_01285	COG1045	serine acetyltransferase
BBB50_01295	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BBB50_01300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BBB50_01305	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BBB50_01310	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BBB50_01315	COG0137	argininosuccinate synthase activity
BBB50_01320	COG0165	Argininosuccinate lyase
BBB50_01330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BBB50_01335	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BBB50_01335	COG0678	peroxiredoxin activity
BBB50_01345	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BBB50_01365	COG3778	Protein conserved in bacteria
BBB50_01370	COG3299	homolog of phage Mu protein gp47
BBB50_01380	COG4384	Bacteriophage Mu Gp45 protein
BBB50_01415	COG4386	tail sheath protein
BBB50_01435	COG4387	Mu-like prophage protein GP36
BBB50_01445	COG4397	Mu-like prophage major head subunit gpT
BBB50_01480	COG4383	Mu-like prophage protein gp29
BBB50_01485	COG4373	Mu-like prophage FluMu protein gp28
BBB50_01495	COG0640	Transcriptional regulator
BBB50_01610	COG2842	Transposition protein
BBB50_01615	COG2801	Transposase and inactivated derivatives
BBB50_01620	COG3423	Transcriptional regulator
BBB50_01655	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BBB50_01660	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BBB50_01670	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BBB50_01675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BBB50_01680	COG0546	phosphoglycolate phosphatase activity
BBB50_01685	COG0180	Tryptophanyl-tRNA synthetase
BBB50_01700	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BBB50_01710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BBB50_01730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BBB50_01735	COG3954	Phosphoribulokinase
BBB50_01745	COG0429	hydrolase of the alpha beta-hydrolase fold
BBB50_01755	COG0488	(ABC) transporter
BBB50_01760	COG2249	NAD(P)H dehydrogenase (quinone) activity
BBB50_01775	COG1047	Peptidyl-prolyl cis-trans
BBB50_01785	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BBB50_01790	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
BBB50_01795	COG3083	sulfuric ester hydrolase activity
BBB50_01800	COG0557	exoribonuclease II activity
BBB50_01805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BBB50_01810	COG0051	transcription antitermination factor activity, RNA binding
BBB50_01815	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BBB50_01820	COG0088	Forms part of the polypeptide exit tunnel
BBB50_01825	COG0089	rRNA binding
BBB50_01830	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BBB50_01835	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BBB50_01840	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BBB50_01845	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BBB50_01850	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BBB50_01855	COG0255	Belongs to the universal ribosomal protein uL29 family
BBB50_01860	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BBB50_01865	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BBB50_01870	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BBB50_01875	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BBB50_01880	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BBB50_01885	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BBB50_01890	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BBB50_01895	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BBB50_01900	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BBB50_01905	COG1841	ribosomal large subunit assembly
BBB50_01910	COG0200	Binds to the 23S rRNA
BBB50_01915	COG0201	protein transport
BBB50_01925	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BBB50_01930	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BBB50_01935	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BBB50_01940	COG0202	RNA polymerase activity
BBB50_01945	COG0203	ribosomal protein L17
BBB50_01955	COG0545	Peptidyl-prolyl cis-trans isomerase
BBB50_01960	COG3061	Opacity-associated protein A
BBB50_01960	COG3266	domain, Protein
BBB50_01965	COG0697	spore germination
BBB50_01970	COG2153	protein acetylation
BBB50_01975	COG0513	Belongs to the DEAD box helicase family
BBB50_01985	COG0737	Belongs to the 5'-nucleotidase family
BBB50_01990	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BBB50_01990	COG1648	precorrin-2 dehydrogenase activity
BBB50_01995	COG0175	sulfate reduction
BBB50_02000	COG2895	sulfate adenylyltransferase (ATP) activity
BBB50_02005	COG0529	Catalyzes the synthesis of activated sulfate
BBB50_02025	COG1136	(ABC) transporter
BBB50_02040	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
BBB50_02045	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BBB50_02050	COG0729	surface antigen
BBB50_02060	COG2105	PFAM AIG2 family protein
BBB50_02065	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BBB50_02070	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BBB50_02080	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BBB50_02085	COG0163	prenyltransferase activity
BBB50_02090	COG4143	(ABC) transporter
BBB50_02095	COG1178	ABC-type Fe3 transport system permease component
BBB50_02100	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
BBB50_02105	COG3028	Belongs to the UPF0307 family
BBB50_02110	COG0312	modulator of DNA gyrase
BBB50_02115	COG2239	Acts as a magnesium transporter
BBB50_02120	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBB50_02130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBB50_02135	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BBB50_02145	COG1137	ATPase activity
BBB50_02150	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BBB50_02165	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BBB50_02165	COG0517	IMP dehydrogenase activity
BBB50_02180	COG1127	ABC transporter
BBB50_02185	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BBB50_02190	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BBB50_02195	COG2854	intermembrane phospholipid transfer
BBB50_02205	COG5007	Belongs to the BolA IbaG family
BBB50_02210	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BBB50_02215	COG0204	Acyl-transferase
BBB50_02220	COG0251	oxidation-reduction process
BBB50_02225	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
BBB50_02230	COG0540	Belongs to the ATCase OTCase family
BBB50_02240	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BBB50_02245	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BBB50_02255	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BBB50_02260	COG0564	pseudouridine synthase activity
BBB50_02265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BBB50_02270	COG0525	valine-tRNA ligase activity
BBB50_02275	COG2927	DNA polymerase III (CHI subunit)
BBB50_02280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BBB50_02285	COG0795	lipopolysaccharide-transporting ATPase activity
BBB50_02290	COG0795	lipopolysaccharide-transporting ATPase activity
BBB50_02305	COG3437	response regulator, receiver
BBB50_02350	COG0066	3-isopropylmalate dehydratase activity
BBB50_02355	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BBB50_02360	COG0473	3-isopropylmalate dehydrogenase activity
BBB50_02365	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BBB50_02385	COG0583	DNA-binding transcription factor activity
BBB50_02390	COG1022	Amp-dependent synthetase and ligase
BBB50_02395	COG0028	Belongs to the TPP enzyme family
BBB50_02400	COG0440	acetolactate synthase activity
BBB50_02405	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BBB50_02410	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BBB50_02415	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BBB50_02425	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BBB50_02435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BBB50_02440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BBB50_02450	COG0354	folic acid binding
BBB50_02455	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BBB50_02465	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BBB50_02475	COG1595	DNA-templated transcription, initiation
BBB50_02485	COG3026	antisigma factor binding
BBB50_02490	COG3086	response to oxidative stress
BBB50_02495	COG0481	GTPase activity
BBB50_02500	COG0681	Belongs to the peptidase S26 family
BBB50_02505	COG0571	ribonuclease III activity
BBB50_02510	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BBB50_02515	COG1381	Involved in DNA repair and RecF pathway recombination
BBB50_02520	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BBB50_02525	COG0736	holo-[acyl-carrier-protein] synthase activity
BBB50_02540	COG5001	Diguanylate cyclase
BBB50_02550	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BBB50_02555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BBB50_02560	COG3956	TIGRFAM MazG family protein
BBB50_02565	COG0504	CTP synthase activity
BBB50_02570	COG0148	phosphopyruvate hydratase activity
BBB50_02575	COG0617	tRNA 3'-terminal CCA addition
BBB50_02580	COG3409	Peptidoglycan-binding domain 1 protein
BBB50_02580	COG3267	Type II secretory pathway component ExeA
BBB50_02595	COG0306	phosphate transporter
BBB50_02600	COG1392	Phosphate transport regulator
BBB50_02605	COG3025	triphosphatase activity
BBB50_02610	COG0840	transmembrane signaling receptor activity
BBB50_02615	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BBB50_02625	COG1538	Outer membrane efflux protein
BBB50_02630	COG0494	nUDIX hydrolase
BBB50_02635	COG3151	Protein conserved in bacteria
BBB50_02645	COG3150	esterase
BBB50_02650	COG0187	DNA topoisomerase II activity
BBB50_02655	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BBB50_02660	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BBB50_02665	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
BBB50_02670	COG0237	dephospho-CoA kinase activity
BBB50_02680	COG1459	type II secretion system
BBB50_02685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BBB50_02705	COG0716	FMN binding
BBB50_02710	COG4974	Belongs to the 'phage' integrase family
BBB50_02715	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BBB50_02720	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BBB50_02725	COG0737	Belongs to the 5'-nucleotidase family
BBB50_02730	COG2186	Transcriptional regulator
BBB50_02735	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BBB50_02740	COG0508	dehydrogenase complex catalyzes the overall conversion of
BBB50_02745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BBB50_02755	COG0275	rRNA processing
BBB50_02760	COG3116	cell division
BBB50_02765	COG0768	penicillin binding
BBB50_02770	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BBB50_02775	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BBB50_02780	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BBB50_02785	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BBB50_02790	COG0772	Belongs to the SEDS family
BBB50_02795	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BBB50_02800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BBB50_02805	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BBB50_02810	COG0849	cell division
BBB50_02815	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BBB50_02820	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BBB50_02830	COG0653	protein targeting
BBB50_02840	COG0494	nUDIX hydrolase
BBB50_02845	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BBB50_02855	COG0505	Belongs to the CarA family
BBB50_02860	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BBB50_02880	COG4172	Belongs to the ABC transporter superfamily
BBB50_02890	COG0730	response to heat
BBB50_02895	COG0583	DNA-binding transcription factor activity
BBB50_02900	COG2860	membrane
BBB50_02905	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BBB50_02915	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BBB50_02925	COG0493	'glutamate synthase
BBB50_02930	COG0067	glutamate synthase
BBB50_02930	COG0070	glutamate synthase
BBB50_02930	COG0069	glutamate synthase activity
BBB50_02940	COG0069	glutamate synthase activity
BBB50_02940	COG0067	glutamate synthase
BBB50_02940	COG0070	glutamate synthase
BBB50_02945	COG1242	4 iron, 4 sulfur cluster binding
BBB50_02950	COG5001	Diguanylate cyclase
BBB50_02950	COG4251	negative regulation of phosphorylation
BBB50_02950	COG3706	GGDEF domain
BBB50_02950	COG2203	Gaf domain
BBB50_02955	COG5002	protein histidine kinase activity
BBB50_02955	COG2198	Histidine kinase
BBB50_02955	COG0784	Response regulator, receiver
BBB50_02960	COG0745	RESPONSE REGULATOR receiver
BBB50_02970	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BBB50_02985	COG0083	homoserine kinase activity
BBB50_02990	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BBB50_02995	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
BBB50_03000	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BBB50_03005	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BBB50_03020	COG1115	amino acid carrier protein
BBB50_03030	COG0084	hydrolase, TatD family'
BBB50_03035	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BBB50_03045	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BBB50_03050	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BBB50_03055	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BBB50_03060	COG0813	purine-nucleoside phosphorylase activity
BBB50_03070	COG0560	Phosphoserine phosphatase
BBB50_03080	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BBB50_03085	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BBB50_03090	COG1022	Amp-dependent synthetase and ligase
BBB50_03110	COG1609	Transcriptional regulator
BBB50_03115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BBB50_03130	COG0189	ligase activity
BBB50_03130	COG0569	domain protein
BBB50_03135	COG0456	acetyltransferase
BBB50_03145	COG2171	N-acyltransferase activity
BBB50_03150	COG3141	response to X-ray
BBB50_03165	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BBB50_03170	COG1074	ATP-dependent DNA helicase activity
BBB50_03175	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BBB50_03190	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BBB50_03190	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BBB50_03200	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
BBB50_03205	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BBB50_03210	COG2166	iron-sulfur cluster assembly
BBB50_03215	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BBB50_03220	COG0693	protein deglycase activity
BBB50_03225	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BBB50_03230	COG3248	Nucleoside-binding outer membrane protein
BBB50_03240	COG1595	DNA-templated transcription, initiation
BBB50_03250	COG2211	Major facilitator Superfamily
BBB50_03255	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BBB50_03265	COG2813	Specifically methylates the guanine in position
BBB50_03270	COG0271	Belongs to the BolA IbaG family
BBB50_03275	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BBB50_03280	COG1805	sodium ion transport
BBB50_03285	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BBB50_03290	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BBB50_03295	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BBB50_03300	COG2871	sodium ion transport
BBB50_03305	COG1477	protein flavinylation
BBB50_03315	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BBB50_03325	COG3706	GGDEF domain
BBB50_03330	COG0733	neurotransmitter:sodium symporter activity
BBB50_03340	COG0189	ligase activity
BBB50_03345	COG4067	protein conserved in archaea
BBB50_03345	COG0189	ligase activity
BBB50_03350	COG2195	Cleaves the N-terminal amino acid of tripeptides
BBB50_03355	COG2252	PERMEase
BBB50_03360	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
BBB50_03375	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BBB50_03380	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BBB50_03385	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BBB50_03390	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BBB50_03390	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BBB50_03405	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BBB50_03410	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BBB50_03415	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BBB50_03420	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BBB50_03430	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BBB50_03435	COG0024	Methionine aminopeptidase
BBB50_03440	COG0052	Belongs to the universal ribosomal protein uS2 family
BBB50_03445	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BBB50_03450	COG0528	UMP kinase activity
BBB50_03455	COG0233	cytoplasmic translational termination
BBB50_03460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BBB50_03465	COG0575	Belongs to the CDS family
BBB50_03470	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BBB50_03475	COG0750	zinc metalloprotease
BBB50_03485	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
BBB50_03490	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BBB50_03495	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BBB50_03500	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BBB50_03505	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BBB50_03510	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BBB50_03515	COG0587	DNA-directed DNA polymerase activity
BBB50_03520	COG0825	malonyl-CoA metabolic process
BBB50_03525	COG0037	tRNA processing
BBB50_03535	COG3479	Phenolic acid decarboxylase
BBB50_03540	COG0347	Belongs to the P(II) protein family
BBB50_03550	COG1388	LysM domain
BBB50_03550	COG0741	lytic transglycosylase activity
BBB50_03555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BBB50_03560	COG2226	methyltransferase
BBB50_03565	COG0328	RNA-DNA hybrid ribonuclease activity
BBB50_03570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BBB50_03580	COG1960	acyl-CoA dehydrogenase activity
BBB50_03585	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BBB50_03590	COG0121	glutamine amidotransferase
BBB50_03595	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BBB50_03600	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BBB50_03605	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BBB50_03610	COG3706	GGDEF domain
BBB50_03615	COG1187	pseudouridine synthase activity
BBB50_03620	COG2840	Smr protein MutS2
BBB50_03635	COG3735	TraB family
BBB50_03650	COG2608	mercury ion transmembrane transporter activity
BBB50_03650	COG2217	Heavy metal translocating P-type atpase
BBB50_03655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BBB50_03670	COG4774	siderophore transport
BBB50_03670	COG1629	transport
BBB50_03675	COG2375	cellular response to nickel ion
BBB50_03680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BBB50_03680	COG2226	methyltransferase
BBB50_03680	COG3433	isochorismatase activity
BBB50_03715	COG0835	chemotaxis
BBB50_03715	COG0784	Response regulator, receiver
BBB50_03720	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BBB50_03725	COG1815	bacterial-type flagellum-dependent cell motility
BBB50_03730	COG1558	bacterial-type flagellum-dependent cell motility
BBB50_03735	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BBB50_03740	COG1749	Flagellar hook protein flgE
BBB50_03745	COG4787	bacterial-type flagellum-dependent cell motility
BBB50_03750	COG4786	Flagellar basal body rod
BBB50_03755	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
BBB50_03760	COG1706	bacterial-type flagellum-dependent cell motility
BBB50_03765	COG3951	Flagellar rod assembly protein muramidase FlgJ
BBB50_03765	COG1705	Flagellar rod assembly protein muramidase FlgJ
BBB50_03785	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BBB50_03790	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BBB50_03875	COG0012	GTP binding
BBB50_03880	COG0193	aminoacyl-tRNA hydrolase activity
BBB50_03885	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BBB50_03890	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BBB50_03895	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BBB50_03900	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BBB50_03905	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BBB50_03910	COG2890	protein-(glutamine-N5) methyltransferase activity
BBB50_03915	COG3094	Invasion gene expression up-regulator, SirB
BBB50_03920	COG2912	Transglutaminase-like superfamily
BBB50_03925	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BBB50_03930	COG0737	Belongs to the 5'-nucleotidase family
BBB50_03935	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BBB50_03940	COG2233	PERMEase
BBB50_03960	COG1393	Belongs to the ArsC family
BBB50_03965	COG4783	chaperone-mediated protein folding
BBB50_03985	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BBB50_03995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BBB50_04000	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
BBB50_04010	COG1876	peptidase activity
BBB50_04015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BBB50_04020	COG1393	Belongs to the ArsC family
BBB50_04040	COG2837	iron assimilation
BBB50_04045	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BBB50_04050	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BBB50_04055	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BBB50_04060	COG1334	flagellar protein FlaG
BBB50_04065	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BBB50_04075	COG1516	flagellar protein fliS
BBB50_04080	COG2204	response regulator
BBB50_04085	COG4191	Histidine kinase
BBB50_04090	COG2204	response regulator
BBB50_04095	COG1677	Flagellar hook-basal body complex protein FliE
BBB50_04105	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BBB50_04130	COG1580	Controls the rotational direction of flagella during chemotaxis
BBB50_04155	COG1987	bacterial-type flagellum assembly
BBB50_04160	COG1684	flagellar biosynthetic protein fliR
BBB50_04175	COG2890	protein-(glutamine-N5) methyltransferase activity
BBB50_04185	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BBB50_04190	COG2860	membrane
BBB50_04195	COG3101	peptidyl-lysine hydroxylation
BBB50_04205	COG0431	NADPH-dependent FMN reductase
BBB50_04210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BBB50_04210	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BBB50_04215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BBB50_04220	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BBB50_04225	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BBB50_04230	COG0735	belongs to the Fur family
BBB50_04240	COG0583	DNA-binding transcription factor activity
BBB50_04250	COG1346	cytolysis
BBB50_04265	COG0596	Alpha beta hydrolase
BBB50_04270	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
BBB50_04275	COG0033	Phosphoglucomutase
BBB50_04285	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BBB50_04290	COG0372	Belongs to the citrate synthase family
BBB50_04295	COG2009	succinate dehydrogenase
BBB50_04300	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BBB50_04305	COG1053	succinate dehydrogenase
BBB50_04315	COG0567	Dehydrogenase, E1 component
BBB50_04320	COG0508	dehydrogenase complex catalyzes the overall conversion of
BBB50_04325	COG0045	succinate-CoA ligase (ADP-forming) activity
BBB50_04335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BBB50_04340	COG1121	(ABC) transporter
BBB50_04345	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
BBB50_04350	COG4977	sequence-specific DNA binding
BBB50_04355	COG1918	ferrous iron import across plasma membrane
BBB50_04375	COG0018	arginyl-trna synthetase
BBB50_04385	COG1025	Belongs to the peptidase M16 family
BBB50_04390	COG2062	phosphohistidine phosphatase, SixA
BBB50_04405	COG0455	bacterial-type flagellum organization
BBB50_04420	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
BBB50_04425	COG0643	Histidine kinase
BBB50_04425	COG2198	Histidine kinase
BBB50_04430	COG2201	protein-glutamate methylesterase activity
BBB50_04435	COG1192	Involved in chromosome partitioning
BBB50_04445	COG0835	chemotaxis
BBB50_04455	COG4133	protoheme IX ABC transporter activity
BBB50_04460	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BBB50_04465	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BBB50_04475	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BBB50_04480	COG1138	Cytochrome C-type biogenesis protein
BBB50_04485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BBB50_04500	COG2853	Lipoprotein
BBB50_04520	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BBB50_04525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BBB50_04530	COG0123	including yeast histone deacetylase and acetoin utilization protein
BBB50_04545	COG3083	sulfuric ester hydrolase activity
BBB50_04555	COG3081	Nucleoid-associated protein
BBB50_04565	COG1757	Na H antiporter
BBB50_04570	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BBB50_04575	COG2095	MarC family integral membrane protein
BBB50_04580	COG1454	alcohol dehydrogenase
BBB50_04580	COG1012	belongs to the aldehyde dehydrogenase family
BBB50_04590	COG0659	secondary active sulfate transmembrane transporter activity
BBB50_04595	COG1530	ribonuclease E activity
BBB50_04610	COG0564	pseudouridine synthase activity
BBB50_04615	COG0424	maF-like protein
BBB50_04620	COG1399	metal-binding, possibly nucleic acid-binding protein
BBB50_04625	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BBB50_04630	COG0416	fatty acid biosynthetic process
BBB50_04635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BBB50_04640	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BBB50_04645	COG1028	Short-chain dehydrogenase reductase Sdr
BBB50_04650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BBB50_04655	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BBB50_04660	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BBB50_04665	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BBB50_04670	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BBB50_04680	COG0084	hydrolase, TatD family'
BBB50_04685	COG1263	PTS System
BBB50_04685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BBB50_04690	COG0733	neurotransmitter:sodium symporter activity
BBB50_04700	COG4667	esterase of the alpha-beta hydrolase superfamily
BBB50_04710	COG1940	carbohydrate kinase activity
BBB50_04715	COG0784	Response regulator, receiver
BBB50_04715	COG0835	chemotaxis
BBB50_04730	COG2226	methyltransferase
BBB50_04740	COG0676	glucose-6-phosphate 1-epimerase activity
BBB50_04745	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BBB50_04750	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BBB50_04760	COG3139	Protein of unknown function (DUF1315)
BBB50_04765	COG0252	asparaginase activity
BBB50_04770	COG0616	signal peptide processing
BBB50_04775	COG1902	pentaerythritol trinitrate reductase activity
BBB50_04775	COG0446	pyridine nucleotide-disulphide oxidoreductase
BBB50_04780	COG0788	formyltetrahydrofolate deformylase activity
BBB50_04790	COG1199	ATP-dependent helicase activity
BBB50_04795	COG1214	PFAM Peptidase M22, glycoprotease
BBB50_04810	COG0596	Alpha beta hydrolase
BBB50_04815	COG0318	PFAM AMP-dependent synthetase and ligase
BBB50_04820	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BBB50_04840	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BBB50_04845	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BBB50_04850	COG0436	Aminotransferase
BBB50_04855	COG1169	isochorismate synthase
BBB50_04860	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BBB50_04865	COG0596	Alpha beta hydrolase
BBB50_04875	COG1441	menaquinone biosynthetic process
BBB50_04885	COG3135	benzoate transporter
BBB50_04890	COG1396	sequence-specific DNA binding
BBB50_04895	COG0840	transmembrane signaling receptor activity
BBB50_04905	COG0477	Major facilitator Superfamily
BBB50_04925	COG3015	lipoprotein NlpE involved in copper resistance
BBB50_04930	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BBB50_04935	COG2894	cell division
BBB50_04940	COG0850	regulation of cytokinetic process
BBB50_04945	COG3100	YcgL domain-containing protein
BBB50_04950	COG2951	lytic endotransglycosylase activity
BBB50_04960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BBB50_04965	COG3469	chitinase activity
BBB50_04965	COG3325	Belongs to the glycosyl hydrolase 18 family
BBB50_04970	COG3005	denitrification pathway
BBB50_04975	COG0243	molybdopterin cofactor binding
BBB50_04990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BBB50_05005	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BBB50_05040	COG4589	Belongs to the CDS family
BBB50_05050	COG5001	Diguanylate cyclase
BBB50_05050	COG3300	MHYT domain
BBB50_05065	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BBB50_05070	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BBB50_05075	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BBB50_05080	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BBB50_05090	COG4191	Histidine kinase
BBB50_05100	COG0544	peptidyl-prolyl cis-trans isomerase activity
BBB50_05110	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BBB50_05115	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BBB50_05120	COG0776	regulation of translation
BBB50_05125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BBB50_05130	COG1555	photosystem II stabilization
BBB50_05135	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BBB50_05140	COG0539	negative regulation of cytoplasmic translation
BBB50_05145	COG0776	regulation of translation
BBB50_05150	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
BBB50_05155	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BBB50_05160	COG0284	orotidine-5'-phosphate decarboxylase activity
BBB50_05175	COG0583	DNA-binding transcription factor activity
BBB50_05185	COG0686	Belongs to the AlaDH PNT family
BBB50_05195	COG1674	ftsk spoiiie
BBB50_05200	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BBB50_05205	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BBB50_05210	COG2186	Transcriptional regulator
BBB50_05225	COG0537	adenosine 5'-monophosphoramidase activity
BBB50_05255	COG1252	NADH dehydrogenase
BBB50_05275	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BBB50_05285	COG4591	ABC-type transport system involved in lipoprotein release permease component
BBB50_05290	COG1136	(ABC) transporter
BBB50_05295	COG4591	ABC-type transport system involved in lipoprotein release permease component
BBB50_05305	COG0658	competence protein
BBB50_05305	COG2333	competence protein COMEC
BBB50_05310	COG1132	(ABC) transporter
BBB50_05315	COG1663	tetraacyldisaccharide 4'-kinase activity
BBB50_05325	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BBB50_05330	COG2719	SpoVR family
BBB50_05335	COG2718	Belongs to the UPF0229 family
BBB50_05340	COG2766	serine protein kinase
BBB50_05345	COG3013	Belongs to the UPF0304 family
BBB50_05355	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BBB50_05360	COG0840	transmembrane signaling receptor activity
BBB50_05370	COG1882	Formate acetyltransferase
BBB50_05390	COG4215	(ABC) transporter
BBB50_05395	COG4160	amino acid transport
BBB50_05400	COG0708	Exodeoxyribonuclease III
BBB50_05405	COG0840	transmembrane signaling receptor activity
BBB50_05415	COG3923	Primosomal replication protein n
BBB50_05420	COG0730	response to heat
BBB50_05425	COG1199	ATP-dependent helicase activity
BBB50_05430	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BBB50_05435	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
BBB50_05445	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BBB50_05450	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BBB50_05455	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BBB50_05460	COG0215	cysteine-tRNA ligase activity
BBB50_05465	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BBB50_05470	COG0632	four-way junction helicase activity
BBB50_05475	COG2255	four-way junction helicase activity
BBB50_05480	COG1271	oxidase subunit
BBB50_05485	COG1294	oxidase, subunit
BBB50_05490	COG4890	Cyd operon protein YbgT
BBB50_05495	COG3790	cyd operon protein YbgE
BBB50_05500	COG0824	Thioesterase
BBB50_05505	COG0811	peptide transport
BBB50_05520	COG0823	Involved in the tonB-independent uptake of proteins
BBB50_05525	COG2885	chlorophyll binding
BBB50_05535	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BBB50_05545	COG0784	Response regulator, receiver
BBB50_05545	COG5002	protein histidine kinase activity
BBB50_05555	COG1482	cell wall glycoprotein biosynthetic process
BBB50_05560	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BBB50_05560	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BBB50_05560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBB50_05565	COG2207	Transcriptional regulator
BBB50_05575	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BBB50_05580	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BBB50_05585	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BBB50_05595	COG1012	belongs to the aldehyde dehydrogenase family
BBB50_05600	COG3284	Transcriptional regulator
BBB50_05605	COG4628	conserved protein (DUF2132)
BBB50_05615	COG0415	Belongs to the DNA photolyase family
BBB50_05685	COG0488	(ABC) transporter
BBB50_05725	COG3941	tape measure
BBB50_05745	COG2003	Belongs to the UPF0758 family
BBB50_05755	COG4409	exo-alpha-(2->6)-sialidase activity
BBB50_05760	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BBB50_05765	COG1940	carbohydrate kinase activity
BBB50_05770	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BBB50_05780	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BBB50_05785	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BBB50_05790	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BBB50_05795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BBB50_05800	COG1737	Transcriptional regulator
BBB50_05805	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
BBB50_05810	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
BBB50_05830	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BBB50_05850	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BBB50_05870	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BBB50_05880	COG0582	viral genome integration into host DNA
BBB50_05895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BBB50_05905	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BBB50_05905	COG3008	intermembrane lipid transfer
BBB50_05910	COG2995	paraquat-inducible protein a
BBB50_05915	COG0668	transmembrane transport
BBB50_05940	COG1309	transcriptional regulator
BBB50_05945	COG1012	belongs to the aldehyde dehydrogenase family
BBB50_05970	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BBB50_05975	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BBB50_05980	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BBB50_05985	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BBB50_05995	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BBB50_06005	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BBB50_06010	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BBB50_06015	COG0297	glycogen (starch) synthase activity
BBB50_06035	COG3070	regulator of competence-specific genes
BBB50_06040	COG1609	Transcriptional regulator
BBB50_06050	COG0745	RESPONSE REGULATOR receiver
BBB50_06055	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BBB50_06060	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BBB50_06065	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
BBB50_06070	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
BBB50_06075	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BBB50_06090	COG1032	radical SAM domain protein
BBB50_06095	COG5001	Diguanylate cyclase
BBB50_06100	COG0612	Peptidase, M16
BBB50_06115	COG0583	DNA-binding transcription factor activity
BBB50_06120	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BBB50_06130	COG2350	Protein conserved in bacteria
BBB50_06135	COG1607	acyl-coa hydrolase
BBB50_06140	COG2917	probably involved in intracellular septation
BBB50_06150	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BBB50_06155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BBB50_06165	COG2116	formate transmembrane transporter activity
BBB50_06175	COG4459	periplasmic nitrate reductase
BBB50_06180	COG3005	denitrification pathway
BBB50_06185	COG0243	molybdopterin cofactor binding
BBB50_06205	COG1227	inorganic diphosphatase activity
BBB50_06220	COG4172	Belongs to the ABC transporter superfamily
BBB50_06230	COG4171	peptide transport system, permease
BBB50_06235	COG4168	peptide transport system, permease
BBB50_06245	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BBB50_06250	COG1842	Phage shock protein A
BBB50_06265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BBB50_06280	COG2818	Glycosylase
BBB50_06285	COG0626	cystathionine gamma-synthase activity
BBB50_06295	COG0733	neurotransmitter:sodium symporter activity
BBB50_06300	COG0564	pseudouridine synthase activity
BBB50_06305	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BBB50_06310	COG4136	ATPase activity
BBB50_06315	COG4135	transport system, permease component
BBB50_06320	COG4134	Bacterial extracellular solute-binding protein
BBB50_06330	COG3313	Fe-S protein
BBB50_06340	COG0842	Transport permease protein
BBB50_06345	COG1131	(ABC) transporter
BBB50_06350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BBB50_06355	COG0814	amino acid
BBB50_06365	COG2239	Acts as a magnesium transporter
BBB50_06385	COG4934	collagen metabolic process
BBB50_06415	COG0840	transmembrane signaling receptor activity
BBB50_06430	COG3706	GGDEF domain
BBB50_06430	COG5001	Diguanylate cyclase
BBB50_06430	COG2203	Gaf domain
BBB50_06430	COG4251	negative regulation of phosphorylation
BBB50_06435	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BBB50_06455	COG1061	Type III restriction enzyme res subunit
BBB50_06460	COG1187	pseudouridine synthase activity
BBB50_06465	COG2814	Major facilitator Superfamily
BBB50_06475	COG0702	epimerase
BBB50_06480	COG0534	Mate efflux family protein
BBB50_06485	COG4181	ATPase activity
BBB50_06500	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BBB50_06510	COG1748	Saccharopine dehydrogenase
BBB50_06515	COG0019	diaminopimelate decarboxylase activity
BBB50_06525	COG1538	Outer membrane efflux protein
BBB50_06550	COG0583	DNA-binding transcription factor activity
BBB50_06560	COG1451	nucleotide metabolic process
BBB50_06575	COG3063	Type IV pilus biogenesis stability protein PilW
BBB50_06580	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BBB50_06600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BBB50_06615	COG3290	protein histidine kinase activity
BBB50_06620	COG4565	transcriptional regulatory protein
BBB50_06630	COG0835	chemotaxis
BBB50_06630	COG0784	Response regulator, receiver
BBB50_06645	COG0745	RESPONSE REGULATOR receiver
BBB50_06645	COG3706	GGDEF domain
BBB50_06670	COG1085	galactose-1-phosphate uridylyltransferase
BBB50_06675	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BBB50_06680	COG2017	converts alpha-aldose to the beta-anomer
BBB50_06685	COG3706	GGDEF domain
BBB50_06690	COG2199	diguanylate cyclase activity
BBB50_06690	COG2200	EAL domain
BBB50_06705	COG3527	Alpha-acetolactate decarboxylase
BBB50_06720	COG0753	catalase activity
BBB50_06740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BBB50_06750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BBB50_06790	COG1271	oxidase subunit
BBB50_06795	COG1294	oxidase, subunit
BBB50_06800	COG4591	ABC-type transport system involved in lipoprotein release permease component
BBB50_06800	COG1136	(ABC) transporter
BBB50_06805	COG1136	(ABC) transporter
BBB50_06805	COG0577	efflux transmembrane transporter activity
BBB50_06810	COG1136	(ABC) transporter
BBB50_06810	COG0577	efflux transmembrane transporter activity
BBB50_06830	COG0583	DNA-binding transcription factor activity
BBB50_06835	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BBB50_06840	COG2723	6-phospho-beta-galactosidase activity
BBB50_06845	COG1609	Transcriptional regulator
BBB50_06850	COG0251	oxidation-reduction process
BBB50_06855	COG2731	YhcH YjgK YiaL family protein
BBB50_06860	COG0584	glycerophosphoryl diester phosphodiesterase
BBB50_06865	COG1349	DNA-binding transcription factor activity
BBB50_06870	COG3842	ATPase activity
BBB50_06875	COG0395	ABC-type sugar transport system, permease component
BBB50_06880	COG1175	transmembrane transport
BBB50_06895	COG0811	peptide transport
BBB50_06900	COG0811	peptide transport
BBB50_06905	COG0848	biopolymer transport protein
BBB50_06910	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
BBB50_06920	COG1793	dna ligase
BBB50_06930	COG0534	Mate efflux family protein
BBB50_06950	COG0791	NLP P60 protein
BBB50_06955	COG0840	transmembrane signaling receptor activity
BBB50_06970	COG1940	carbohydrate kinase activity
BBB50_07000	COG0746	molybdenum cofactor guanylyltransferase activity
BBB50_07005	COG3842	ATPase activity
BBB50_07010	COG4662	Binding-protein-dependent transport system inner membrane component
BBB50_07020	COG2204	response regulator
BBB50_07025	COG3852	Histidine kinase
BBB50_07030	COG0488	(ABC) transporter
BBB50_07035	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BBB50_07065	COG0243	molybdopterin cofactor binding
BBB50_07065	COG3383	formate dehydrogenase (NAD+) activity
BBB50_07070	COG0437	4 iron, 4 sulfur cluster binding
BBB50_07085	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BBB50_07095	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BBB50_07110	COG2996	Protein conserved in bacteria
BBB50_07115	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
BBB50_07115	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BBB50_07120	COG3008	intermembrane lipid transfer
BBB50_07125	COG2995	paraquat-inducible protein a
BBB50_07130	COG1132	(ABC) transporter
BBB50_07135	COG1956	GAF domain-containing protein
BBB50_07140	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
BBB50_07155	COG0308	aminopeptidase N
BBB50_07170	COG0167	dihydroorotate dehydrogenase activity
BBB50_07180	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BBB50_07180	COG0116	Belongs to the methyltransferase superfamily
BBB50_07205	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BBB50_07210	COG1067	ATP-dependent peptidase activity
BBB50_07215	COG3120	sequence-specific DNA binding
BBB50_07300	COG1073	alpha beta
BBB50_07300	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
BBB50_07300	COG3064	Membrane
BBB50_07305	COG2994	toxin metabolic process
BBB50_07330	COG2205	protein histidine kinase activity
BBB50_07330	COG0784	Response regulator, receiver
BBB50_07345	COG3278	Belongs to the heme-copper respiratory oxidase family
BBB50_07360	COG2010	Cytochrome c
BBB50_07370	COG2217	Heavy metal translocating P-type atpase
BBB50_07385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BBB50_07390	COG0589	response to stress
BBB50_07395	COG0037	tRNA processing
BBB50_07435	COG0017	Asparaginyl-tRNA synthetase
BBB50_07440	COG0351	phosphomethylpyrimidine kinase
BBB50_07445	COG3437	response regulator, receiver
BBB50_07445	COG2770	Histidine kinase
BBB50_07455	COG1448	Aminotransferase
BBB50_07470	COG0840	transmembrane signaling receptor activity
BBB50_07485	COG3278	Belongs to the heme-copper respiratory oxidase family
BBB50_07500	COG2010	Cytochrome c
BBB50_07510	COG2217	Heavy metal translocating P-type atpase
BBB50_07525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BBB50_07530	COG0589	response to stress
BBB50_07535	COG0037	tRNA processing
BBB50_07555	COG3842	ATPase activity
BBB50_07560	COG1176	ABC-type spermidine putrescine transport system, permease component I
BBB50_07565	COG1177	transmembrane transport
BBB50_07570	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BBB50_07575	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BBB50_07590	COG1115	amino acid carrier protein
BBB50_07595	COG1280	lysine exporter protein (LysE YggA)
BBB50_07630	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BBB50_07635	COG0840	transmembrane signaling receptor activity
BBB50_07640	COG2814	Major facilitator Superfamily
BBB50_07645	COG1566	PFAM secretion protein HlyD family protein
BBB50_07650	COG1538	Outer membrane efflux protein
BBB50_07660	COG0513	Belongs to the DEAD box helicase family
BBB50_07670	COG0840	transmembrane signaling receptor activity
BBB50_07675	COG3290	protein histidine kinase activity
BBB50_07675	COG0840	transmembrane signaling receptor activity
BBB50_07680	COG0835	chemotaxis
BBB50_07685	COG2201	protein-glutamate methylesterase activity
BBB50_07695	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BBB50_07705	COG0643	Histidine kinase
BBB50_07705	COG2198	Histidine kinase
BBB50_07725	COG2076	Multidrug Resistance protein
BBB50_07730	COG0415	Belongs to the DNA photolyase family
BBB50_07735	COG0477	Major facilitator Superfamily
BBB50_07740	COG0583	DNA-binding transcription factor activity
BBB50_07750	COG0095	Lipoate-protein ligase
BBB50_07755	COG0443	Heat shock 70 kDa protein
BBB50_07765	COG1643	Atp-dependent helicase
BBB50_07805	COG0443	Heat shock 70 kDa protein
BBB50_07810	COG0443	Heat shock 70 kDa protein
BBB50_07815	COG3706	GGDEF domain
BBB50_07845	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BBB50_07850	COG0602	queuosine metabolic process
BBB50_07855	COG0561	phosphatase activity
BBB50_07865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBB50_07870	COG4597	amino acid ABC transporter
BBB50_07875	COG0765	amino acid transport
BBB50_07880	COG1126	abc transporter atp-binding protein
BBB50_07885	COG0670	Belongs to the BI1 family
BBB50_07890	COG2920	part of a sulfur-relay system
BBB50_07895	COG1254	Belongs to the acylphosphatase family
BBB50_07900	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BBB50_07905	COG3706	GGDEF domain
BBB50_07920	COG2205	protein histidine kinase activity
BBB50_07920	COG3850	Histidine kinase
BBB50_07920	COG3437	response regulator, receiver
BBB50_07920	COG4999	Histidine kinase
BBB50_07925	COG3437	response regulator, receiver
BBB50_07930	COG0625	glutathione transferase activity
BBB50_07940	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BBB50_07950	COG2195	Cleaves the N-terminal amino acid of tripeptides
BBB50_07980	COG0372	Belongs to the citrate synthase family
BBB50_07985	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BBB50_07990	COG2186	Transcriptional regulator
BBB50_08025	COG1129	ABC transporter
BBB50_08060	COG0745	RESPONSE REGULATOR receiver
BBB50_08065	COG2205	protein histidine kinase activity
BBB50_08070	COG3713	MltA-interacting MipA family protein
BBB50_08075	COG2990	Protein conserved in bacteria
BBB50_08085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBB50_08085	COG4191	Histidine kinase
BBB50_08090	COG0471	metal ion transport
BBB50_08100	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BBB50_08115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BBB50_08120	COG3283	Transcriptional regulator of aromatic amino acids metabolism
BBB50_08125	COG3768	UPF0283 membrane protein
BBB50_08130	COG3106	COG3106 Predicted ATPase
BBB50_08145	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BBB50_08150	COG0494	nUDIX hydrolase
BBB50_08155	COG0814	amino acid
BBB50_08160	COG1760	l-serine dehydratase
BBB50_08165	COG0720	synthase
BBB50_08175	COG0017	Asparaginyl-tRNA synthetase
BBB50_08180	COG0351	phosphomethylpyrimidine kinase
BBB50_08185	COG2770	Histidine kinase
BBB50_08185	COG3437	response regulator, receiver
BBB50_08195	COG1448	Aminotransferase
BBB50_08210	COG0840	transmembrane signaling receptor activity
BBB50_08215	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BBB50_08220	COG2943	transferase activity, transferring hexosyl groups
BBB50_08225	COG1609	Transcriptional regulator
BBB50_08230	COG3394	polysaccharide catabolic process
BBB50_08235	COG1486	melibiose metabolic process
BBB50_08240	COG1447	Phosphotransferase system cellobiose-specific component IIA
BBB50_08250	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BBB50_08255	COG0726	polysaccharide deacetylase
BBB50_08260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BBB50_08265	COG1846	Transcriptional regulator
BBB50_08290	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BBB50_08305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BBB50_08310	COG3108	Peptidase M15
BBB50_08315	COG2989	Protein conserved in bacteria
BBB50_08340	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BBB50_08350	COG2814	Major facilitator Superfamily
BBB50_08370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BBB50_08375	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BBB50_08380	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BBB50_08425	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
BBB50_08430	COG4139	cobalamin transport
BBB50_08435	COG2988	succinylglutamate desuccinylase activity
BBB50_08450	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BBB50_08455	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BBB50_08460	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BBB50_08470	COG2925	Exonuclease
BBB50_08480	COG1346	cytolysis
BBB50_08485	COG0295	cytidine deaminase activity
BBB50_08495	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BBB50_08505	COG0500	methyltransferase
BBB50_08520	COG0776	regulation of translation
BBB50_08525	COG0072	phenylalanine-tRNA ligase activity
BBB50_08525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BBB50_08530	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BBB50_08540	COG0745	RESPONSE REGULATOR receiver
BBB50_08540	COG3706	GGDEF domain
BBB50_08570	COG0322	excinuclease ABC activity
BBB50_08575	COG2197	response regulator
BBB50_08580	COG0417	DNA replication proofreading
BBB50_08585	COG5001	Diguanylate cyclase
BBB50_08595	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BBB50_08615	COG1228	amidohydrolase
BBB50_08620	COG0010	Belongs to the arginase family
BBB50_08625	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BBB50_08630	COG2986	histidine ammonia-lyase
BBB50_08650	COG0247	lactate metabolic process
BBB50_08650	COG0277	FAD linked oxidase domain protein
BBB50_08665	COG2885	chlorophyll binding
BBB50_08685	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BBB50_08695	COG0281	malic enzyme
BBB50_08705	COG2949	membrane
BBB50_08710	COG3706	GGDEF domain
BBB50_08715	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BBB50_08725	COG0492	ferredoxin-NADP+ reductase activity
BBB50_08730	COG4988	ABC transporter
BBB50_08735	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BBB50_08740	COG1187	pseudouridine synthase activity
BBB50_08745	COG0009	L-threonylcarbamoyladenylate synthase
BBB50_08750	COG0613	PHP domain protein
BBB50_08760	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BBB50_08765	COG0512	Glutamine amidotransferase of anthranilate synthase
BBB50_08770	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BBB50_08775	COG0134	indole-3-glycerol-phosphate synthase activity
BBB50_08775	COG0135	phosphoribosylanthranilate isomerase activity
BBB50_08780	COG0133	tryptophan synthase activity
BBB50_08785	COG0159	tryptophan synthase activity
BBB50_08795	COG1435	thymidine kinase activity
BBB50_08800	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BBB50_08805	COG1801	Protein of unknown function DUF72
BBB50_08810	COG4106	trans-aconitate 2-methyltransferase activity
BBB50_08815	COG0500	methyltransferase
BBB50_08820	COG0189	ligase activity
BBB50_08820	COG4067	protein conserved in archaea
BBB50_08835	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BBB50_08845	COG3852	Histidine kinase
BBB50_08860	COG3070	regulator of competence-specific genes
BBB50_08870	COG2431	L-lysine efflux transmembrane transporter activity
BBB50_08880	COG0076	glutamate decarboxylase activity
BBB50_08885	COG1737	Transcriptional regulator
BBB50_08890	COG1454	alcohol dehydrogenase
BBB50_08890	COG1012	belongs to the aldehyde dehydrogenase family
BBB50_08895	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BBB50_08905	COG0542	response to heat
BBB50_08910	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BBB50_08915	COG1278	Cold shock
BBB50_08925	COG1187	pseudouridine synthase activity
BBB50_08930	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BBB50_08930	COG0140	phosphoribosyl-ATP diphosphatase activity
BBB50_08935	COG0107	imidazoleglycerol-phosphate synthase activity
BBB50_08940	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BBB50_08945	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BBB50_08950	COG0131	Imidazoleglycerol-phosphate dehydratase
BBB50_08950	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BBB50_08955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BBB50_08960	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BBB50_08965	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BBB50_08970	COG1757	Na H antiporter
BBB50_08975	COG2916	Histone family protein nucleoid-structuring protein H-NS
BBB50_08980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BBB50_08985	COG0482	sulfurtransferase activity
BBB50_08990	COG2915	High frequency lysogenization protein hflD homolog
BBB50_08995	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BBB50_09005	COG2268	Band 7 protein
BBB50_09015	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BBB50_09030	COG0300	oxidoreductase activity
BBB50_09040	COG0501	Belongs to the peptidase M48B family
BBB50_09050	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BBB50_09055	COG2226	methyltransferase
BBB50_09060	COG0156	8-amino-7-oxononanoate synthase activity
BBB50_09065	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BBB50_09070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BBB50_09075	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BBB50_09080	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BBB50_09085	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BBB50_09095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BBB50_09100	COG2199	diguanylate cyclase activity
BBB50_09100	COG2203	Gaf domain
BBB50_09110	COG4120	Belongs to the binding-protein-dependent transport system permease family
BBB50_09120	COG4628	conserved protein (DUF2132)
BBB50_09125	COG3092	negative regulation of chromosome organization
BBB50_09130	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BBB50_09135	COG0857	belongs to the CobB CobQ family
BBB50_09135	COG0280	phosphate acetyltransferase
BBB50_09140	COG0435	Glutathione S-transferase
BBB50_09145	COG4608	Belongs to the ABC transporter superfamily
BBB50_09150	COG0444	Belongs to the ABC transporter superfamily
BBB50_09155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBB50_09160	COG0601	transmembrane transport
BBB50_09180	COG2204	response regulator
BBB50_09185	COG5001	Diguanylate cyclase
BBB50_09185	COG3300	MHYT domain
BBB50_09190	COG4191	Histidine kinase
BBB50_09195	COG5002	protein histidine kinase activity
BBB50_09205	COG2201	protein-glutamate methylesterase activity
BBB50_09220	COG0009	L-threonylcarbamoyladenylate synthase
BBB50_09240	COG1881	PFAM PEBP family protein
BBB50_09265	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BBB50_09270	COG0640	Transcriptional regulator
BBB50_09280	COG3706	GGDEF domain
BBB50_09300	COG1946	Acyl-CoA thioesterase
BBB50_09305	COG1522	sequence-specific DNA binding
BBB50_09315	COG0616	signal peptide processing
BBB50_09320	COG1028	Short-chain dehydrogenase reductase Sdr
BBB50_09335	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BBB50_09340	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BBB50_09350	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BBB50_09355	COG2832	Protein of unknown function (DUF454)
BBB50_09365	COG0745	RESPONSE REGULATOR receiver
BBB50_09370	COG0583	DNA-binding transcription factor activity
BBB50_09375	COG0778	Nitroreductase
BBB50_09380	COG1024	Enoyl-CoA hydratase
BBB50_09380	COG1250	3-hydroxyacyl-CoA dehydrogenase
BBB50_09385	COG0183	Belongs to the thiolase family
BBB50_09400	COG2067	long-chain fatty acid transport protein
BBB50_09410	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BBB50_09415	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
BBB50_09420	COG2982	Protein involved in outer membrane biogenesis
BBB50_09425	COG0572	uridine kinase
BBB50_09435	COG0489	protein tyrosine kinase activity
BBB50_09440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BBB50_09440	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BBB50_09450	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
BBB50_09465	COG4109	DRTGG domain
BBB50_09470	COG2199	diguanylate cyclase activity
BBB50_09475	COG0314	molybdopterin synthase activity
BBB50_09480	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BBB50_09485	COG0315	cyclic pyranopterin monophosphate synthase activity
BBB50_09490	COG0521	Mo-molybdopterin cofactor biosynthetic process
BBB50_09495	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BBB50_09500	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BBB50_09505	COG2198	Histidine kinase
BBB50_09510	COG2204	response regulator
BBB50_09520	COG0556	nucleotide-excision repair
BBB50_09530	COG4657	Part of a membrane complex involved in electron transport
BBB50_09535	COG2878	Part of a membrane complex involved in electron transport
BBB50_09540	COG4656	Part of a membrane complex involved in electron transport
BBB50_09545	COG4658	electron transport chain
BBB50_09550	COG4659	FMN binding
BBB50_09555	COG4660	Part of a membrane complex involved in electron transport
BBB50_09560	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BBB50_09565	COG0346	lactoylglutathione lyase activity
BBB50_09585	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BBB50_09590	COG2056	Na+-H+ antiporter family
BBB50_09595	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BBB50_09600	COG1286	toxin biosynthetic process
BBB50_09605	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
BBB50_09610	COG0285	dihydrofolate synthase activity
BBB50_09615	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BBB50_09620	COG0101	tRNA pseudouridine synthase activity
BBB50_09630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BBB50_09635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BBB50_09635	COG1263	PTS System
BBB50_09635	COG2190	(PTS) system
BBB50_09640	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BBB50_09645	COG1940	carbohydrate kinase activity
BBB50_09645	COG1846	Transcriptional regulator
BBB50_09650	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BBB50_09650	COG4651	solute:proton antiporter activity
BBB50_09655	COG0367	asparagine synthase
BBB50_09670	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BBB50_09675	COG0563	adenylate kinase activity
BBB50_09680	COG0326	Molecular chaperone. Has ATPase activity
BBB50_09685	COG3710	Transcriptional regulator
BBB50_09700	COG0622	Phosphoesterase
BBB50_09705	COG1090	epimerase
BBB50_09710	COG0300	oxidoreductase activity
BBB50_09715	COG3118	belongs to the thioredoxin family
BBB50_09720	COG0330	HflC and HflK could
BBB50_09725	COG1585	Membrane protein implicated in regulation of membrane protease activity
BBB50_09730	COG0789	Transcriptional regulator
BBB50_09745	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BBB50_09750	COG3115	cell septum assembly
BBB50_09755	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
BBB50_09760	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BBB50_09770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBB50_09780	COG2190	(PTS) system
BBB50_09785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BBB50_09790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BBB50_09795	COG1702	phosphate starvation-inducible protein PhoH
BBB50_09800	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BBB50_09805	COG4535	Mg2 and Co2 transporter CorC
BBB50_09810	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BBB50_09815	COG2888	peptidyl-tyrosine sulfation
BBB50_09820	COG0495	leucyl-tRNA aminoacylation
BBB50_09825	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
BBB50_09830	COG1466	dna polymerase III delta subunit
BBB50_09835	COG0799	negative regulation of ribosome biogenesis
BBB50_09840	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BBB50_09845	COG0768	penicillin binding
BBB50_09850	COG0772	Belongs to the SEDS family
BBB50_09855	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BBB50_09860	COG1686	Belongs to the peptidase S11 family
BBB50_09865	COG2921	Belongs to the UPF0250 family
BBB50_09870	COG0321	lipoyl(octanoyl) transferase activity
BBB50_09875	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BBB50_09885	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BBB50_09910	COG1596	polysaccharide export
BBB50_09920	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BBB50_09950	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BBB50_09960	COG0438	transferase activity, transferring glycosyl groups
BBB50_09970	COG1045	serine acetyltransferase
BBB50_09990	COG0110	maltose O-acetyltransferase activity
BBB50_09995	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BBB50_10000	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BBB50_10005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BBB50_10010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BBB50_10040	COG0366	Alpha amylase catalytic
BBB50_10045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BBB50_10045	COG1263	PTS System
BBB50_10050	COG1609	Transcriptional regulator
BBB50_10055	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BBB50_10060	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BBB50_10065	COG2011	ABC-type metal ion transport system permease component
BBB50_10070	COG1464	Belongs to the NlpA lipoprotein family
BBB50_10075	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
BBB50_10085	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BBB50_10085	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BBB50_10095	COG3706	GGDEF domain
BBB50_10100	COG1611	Belongs to the LOG family
BBB50_10105	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BBB50_10110	COG2363	Small membrane protein
BBB50_10115	COG0583	DNA-binding transcription factor activity
BBB50_10125	COG0301	tRNA thio-modification
BBB50_10125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BBB50_10135	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BBB50_10140	COG1722	exodeoxyribonuclease VII activity
BBB50_10145	COG0142	geranyltranstransferase activity
BBB50_10150	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BBB50_10155	COG0564	pseudouridine synthase activity
BBB50_10160	COG3098	single-species biofilm formation
BBB50_10175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BBB50_10185	COG1671	Belongs to the UPF0178 family
BBB50_10190	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BBB50_10195	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BBB50_10200	COG0254	rRNA binding
BBB50_10205	COG1720	tRNA m6t6A37 methyltransferase activity
BBB50_10210	COG0442	prolyl-tRNA aminoacylation
BBB50_10235	COG1943	Transposase
BBB50_10240	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BBB50_10240	COG0047	phosphoribosylformylglycinamidine synthase activity
BBB50_10250	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BBB50_10260	COG0590	tRNA wobble adenosine to inosine editing
BBB50_10265	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BBB50_10300	COG0484	heat shock protein binding
BBB50_10305	COG0443	Heat shock 70 kDa protein
BBB50_10310	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BBB50_10315	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BBB50_10320	COG0497	DNA recombination
BBB50_10325	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BBB50_10330	COG2914	Belongs to the UPF0125 (RnfH) family
BBB50_10335	COG2867	negative regulation of translational initiation
BBB50_10340	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BBB50_10350	COG0582	viral genome integration into host DNA
BBB50_10360	COG3064	Membrane
BBB50_10370	COG0739	heme binding
BBB50_10390	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BBB50_10395	COG2207	Transcriptional regulator
BBB50_10405	COG1459	type II secretion system
BBB50_10410	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BBB50_10430	COG4796	Type ii and iii secretion system protein
BBB50_10445	COG2165	general secretion pathway protein
BBB50_10455	COG3710	Transcriptional regulator
BBB50_10460	COG0840	transmembrane signaling receptor activity
BBB50_10465	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BBB50_10485	COG1012	belongs to the aldehyde dehydrogenase family
BBB50_10555	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
BBB50_10560	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BBB50_10565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BBB50_10575	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
BBB50_10580	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
BBB50_10585	COG3051	citrate lyase alpha subunit
BBB50_10590	COG2301	Belongs to the HpcH HpaI aldolase family
BBB50_10595	COG3052	prosthetic group binding
BBB50_10600	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
BBB50_10610	COG3630	sodium ion export across plasma membrane
BBB50_10615	COG5016	pyruvate
BBB50_10615	COG0511	ligase activity, forming carbon-carbon bonds
BBB50_10620	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BBB50_10630	COG4565	transcriptional regulatory protein
BBB50_10645	COG0583	DNA-binding transcription factor activity
BBB50_10650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BBB50_10655	COG1115	amino acid carrier protein
BBB50_10660	COG2015	COG2015, Alkyl sulfatase and related hydrolases
BBB50_10665	COG0583	DNA-binding transcription factor activity
BBB50_10675	COG1120	ATPase activity
BBB50_10680	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBB50_10685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBB50_10690	COG4592	Periplasmic binding protein
BBB50_10700	COG1028	Short-chain dehydrogenase reductase Sdr
BBB50_10705	COG1169	isochorismate synthase
BBB50_10710	COG1021	2,3-dihydroxybenzoate-AMP ligase
BBB50_10715	COG3433	isochorismatase activity
BBB50_10715	COG1535	isochorismatase
BBB50_10720	COG1584	GPR1 FUN34 yaaH family protein
BBB50_10730	COG0519	Catalyzes the synthesis of GMP from XMP
BBB50_10730	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BBB50_10735	COG0517	IMP dehydrogenase activity
BBB50_10735	COG0516	GMP reductase activity
BBB50_10740	COG1570	exodeoxyribonuclease VII activity
BBB50_10755	COG1160	GTP binding
BBB50_10760	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BBB50_10765	COG2976	Protein conserved in bacteria
BBB50_10770	COG0124	histidyl-tRNA synthetase
BBB50_10775	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BBB50_10785	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BBB50_10790	COG0105	UTP biosynthetic process
BBB50_10795	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BBB50_10800	COG2975	iron-sulfur cluster assembly
BBB50_10805	COG0633	Ferredoxin
BBB50_10810	COG0443	Heat shock 70 kDa protein
BBB50_10815	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BBB50_10825	COG0822	iron-sulfur transferase activity
BBB50_10830	COG1104	cysteine desulfurase activity
BBB50_10835	COG1959	2 iron, 2 sulfur cluster binding
BBB50_10845	COG0483	inositol monophosphate 1-phosphatase activity
BBB50_10850	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BBB50_10855	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BBB50_10860	COG1862	Preprotein translocase
BBB50_10865	COG0343	queuine tRNA-ribosyltransferase activity
BBB50_10875	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BBB50_10880	COG0517	IMP dehydrogenase activity
BBB50_10890	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BBB50_10895	COG0583	DNA-binding transcription factor activity
BBB50_10900	COG0450	alkyl hydroperoxide reductase
BBB50_10905	COG3142	Participates in the control of copper homeostasis
BBB50_10920	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BBB50_10925	COG0581	inorganic phosphate transmembrane transporter activity
BBB50_10935	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BBB50_10940	COG0248	Ppx GppA phosphatase
BBB50_10950	COG5002	protein histidine kinase activity
BBB50_10955	COG0745	RESPONSE REGULATOR receiver
BBB50_10960	COG2974	May be involved in recombination
BBB50_10970	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BBB50_11015	COG0542	response to heat
BBB50_11025	COG0564	pseudouridine synthase activity
BBB50_11030	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BBB50_11035	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BBB50_11040	COG0077	Prephenate dehydratase
BBB50_11040	COG1605	Chorismate mutase
BBB50_11045	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BBB50_11050	COG5001	Diguanylate cyclase
BBB50_11055	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
BBB50_11060	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
BBB50_11070	COG0488	(ABC) transporter
BBB50_11080	COG1605	Chorismate mutase
BBB50_11080	COG0287	Prephenate dehydrogenase
BBB50_11085	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BBB50_11090	COG3275	phosphorelay sensor kinase activity
BBB50_11095	COG3279	Response regulator of the LytR AlgR family
BBB50_11100	COG1472	Belongs to the glycosyl hydrolase 3 family
BBB50_11105	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BBB50_11110	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BBB50_11125	COG1966	Carbon starvation protein
BBB50_11130	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BBB50_11135	COG1047	Peptidyl-prolyl cis-trans
BBB50_11140	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BBB50_11145	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BBB50_11150	COG0196	riboflavin kinase activity
BBB50_11155	COG0728	peptidoglycan biosynthetic process
BBB50_11160	COG0268	Binds directly to 16S ribosomal RNA
BBB50_11165	COG0640	Transcriptional regulator
BBB50_11170	COG0583	DNA-binding transcription factor activity
BBB50_11175	COG1283	sodium-dependent phosphate transmembrane transporter activity
BBB50_11180	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BBB50_11185	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BBB50_11190	COG0730	response to heat
BBB50_11195	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
BBB50_11200	COG0494	nUDIX hydrolase
BBB50_11210	COG3066	DNA modification
BBB50_11215	COG0667	Aldo Keto reductase
BBB50_11225	COG2204	response regulator
BBB50_11230	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BBB50_11235	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BBB50_11245	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BBB50_11250	COG0513	Belongs to the DEAD box helicase family
BBB50_11255	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BBB50_11275	COG3153	acetyltransferase
BBB50_11310	COG4785	May be involved in cell division
BBB50_11315	COG1185	polyribonucleotide nucleotidyltransferase activity
BBB50_11320	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BBB50_11325	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BBB50_11330	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BBB50_11335	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BBB50_11340	COG0195	Participates in both transcription termination and antitermination
BBB50_11345	COG0779	Required for maturation of 30S ribosomal subunits
BBB50_11360	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BBB50_11365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BBB50_11370	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BBB50_11375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BBB50_11380	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BBB50_11385	COG1534	Rna-binding protein
BBB50_11390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BBB50_11395	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BBB50_11400	COG2027	D-alanyl-D-alanine carboxypeptidase
BBB50_11405	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BBB50_11410	COG0739	heme binding
BBB50_11425	COG0316	Belongs to the HesB IscA family
BBB50_11430	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BBB50_11440	COG0628	permease
BBB50_11445	COG2813	Specifically methylates the guanine in position
BBB50_11460	COG0747	negative chemotaxis
BBB50_11465	COG0601	transmembrane transport
BBB50_11470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBB50_11475	COG0444	Belongs to the ABC transporter superfamily
BBB50_11480	COG4608	Belongs to the ABC transporter superfamily
BBB50_11490	COG2971	BadF BadG BcrA BcrD
BBB50_11510	COG3842	ATPase activity
BBB50_11520	COG1840	ABC-type Fe3 transport system, periplasmic component
BBB50_11525	COG0004	ammonium transporteR
BBB50_11530	COG0347	Belongs to the P(II) protein family
BBB50_11535	COG3112	Uncharacterised protein family (UPF0231)
BBB50_11540	COG1049	propionate catabolic process, 2-methylcitrate cycle
BBB50_11545	COG1752	Esterase of the alpha-beta hydrolase superfamily
BBB50_11550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BBB50_11555	COG1643	Atp-dependent helicase
BBB50_11565	COG1489	DNA binding
BBB50_11570	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BBB50_11575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BBB50_11585	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BBB50_11590	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BBB50_11595	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BBB50_11600	COG0842	Transport permease protein
BBB50_11605	COG1131	(ABC) transporter
BBB50_11610	COG0659	secondary active sulfate transmembrane transporter activity
BBB50_11615	COG0288	reversible hydration of carbon dioxide
BBB50_11630	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BBB50_11635	COG3107	peptidoglycan biosynthetic process
BBB50_11640	COG0792	nuclease activity
BBB50_11645	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BBB50_11650	COG2823	Periplasmic or secreted lipoprotein
BBB50_11655	COG2969	positive regulation of protein catabolic process
BBB50_11660	COG0625	glutathione transferase activity
BBB50_11665	COG2857	Cytochrome c1
BBB50_11670	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BBB50_11675	COG0723	plastoquinol--plastocyanin reductase activity
BBB50_11680	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BBB50_11685	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BBB50_11695	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BBB50_11705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BBB50_11710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BBB50_11715	COG0335	large ribosomal subunit rRNA binding
BBB50_11720	COG0336	Belongs to the RNA methyltransferase TrmD family
BBB50_11725	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BBB50_11730	COG0228	four-way junction DNA binding
BBB50_11735	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BBB50_11740	COG4137	Cytochrome C assembly protein
BBB50_11745	COG4536	flavin adenine dinucleotide binding
BBB50_11750	COG1854	S-ribosylhomocysteine lyase activity
BBB50_11755	COG2918	glutathione biosynthetic process
BBB50_11760	COG0612	Peptidase, M16
BBB50_11765	COG1238	metal cluster binding
BBB50_11775	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BBB50_11780	COG0511	ligase activity, forming carbon-carbon bonds
BBB50_11780	COG5016	pyruvate
BBB50_11785	COG3630	sodium ion export across plasma membrane
BBB50_11830	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BBB50_11835	COG0527	aspartate kinase activity
BBB50_11840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BBB50_11845	COG2137	regulation of response to DNA damage stimulus
BBB50_11850	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BBB50_11860	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BBB50_11865	COG4208	sulfate ABC transporter
BBB50_11885	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BBB50_11890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BBB50_11895	COG1388	LysM domain
BBB50_11895	COG4942	peptidase
BBB50_11900	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BBB50_11905	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BBB50_11910	COG0585	pseudouridine synthase activity
BBB50_11915	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BBB50_11920	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BBB50_11925	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BBB50_11930	COG1968	undecaprenyl-diphosphatase activity
BBB50_11935	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BBB50_11940	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BBB50_11945	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BBB50_11955	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BBB50_11960	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BBB50_11965	COG1610	YqeY-like protein
BBB50_11970	COG0358	DNA primase activity
BBB50_11975	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BBB50_11990	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BBB50_11995	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BBB50_12000	COG1349	DNA-binding transcription factor activity
BBB50_12005	COG0469	pyruvate kinase activity
BBB50_12015	COG0583	DNA-binding transcription factor activity
BBB50_12020	COG1279	arginine transmembrane transporter activity
BBB50_12025	COG0668	transmembrane transport
BBB50_12035	COG0191	fructose-bisphosphate aldolase activity
BBB50_12040	COG0126	phosphoglycerate kinase activity
BBB50_12045	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BBB50_12050	COG4771	TonB-dependent receptor
BBB50_12055	COG0583	DNA-binding transcription factor activity
BBB50_12060	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BBB50_12070	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BBB50_12075	COG3091	SprT-like family
BBB50_12080	COG2356	endonuclease I
BBB50_12085	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BBB50_12090	COG0189	ligase activity
BBB50_12095	COG1678	Uncharacterized ACR, COG1678
BBB50_12100	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BBB50_12105	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BBB50_12125	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BBB50_12130	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BBB50_12135	COG0762	integral membrane protein
BBB50_12150	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BBB50_12155	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BBB50_12160	COG2066	Belongs to the glutaminase family
BBB50_12165	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BBB50_12170	COG1194	a g-specific adenine glycosylase
BBB50_12175	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BBB50_12180	COG0741	lytic transglycosylase activity
BBB50_12235	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BBB50_12240	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BBB50_12245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BBB50_12250	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BBB50_12255	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BBB50_12260	COG2967	ApaG domain
BBB50_12265	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BBB50_12275	COG3610	response to peptide
BBB50_12280	COG2966	Psort location CytoplasmicMembrane, score
BBB50_12285	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BBB50_12290	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BBB50_12295	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BBB50_12300	COG0142	geranyltranstransferase activity
BBB50_12305	COG0531	amino acid
BBB50_12310	COG0039	L-malate dehydrogenase activity
BBB50_12315	COG1438	arginine binding
BBB50_12330	COG0589	response to stress
BBB50_12350	COG2235	arginine
BBB50_12355	COG0312	modulator of DNA gyrase
BBB50_12360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BBB50_12365	COG3164	Protein of unknown function
BBB50_12370	COG1530	ribonuclease E activity
BBB50_12375	COG0424	maF-like protein
BBB50_12380	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BBB50_12385	COG1792	Involved in formation and maintenance of cell shape
BBB50_12390	COG1077	Cell shape determining protein MreB Mrl
BBB50_12435	COG1459	type II secretion system
BBB50_12440	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BBB50_12450	COG3267	Type II secretory pathway component ExeA
BBB50_12450	COG3409	Peptidoglycan-binding domain 1 protein
BBB50_12475	COG2199	diguanylate cyclase activity
BBB50_12475	COG2200	EAL domain
BBB50_12480	COG0629	single-stranded DNA binding
BBB50_12495	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BBB50_12505	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BBB50_12510	COG0527	aspartate kinase activity
BBB50_12515	COG1410	methionine synthase
BBB50_12515	COG0646	methionine synthase
BBB50_12590	COG0175	sulfate reduction
BBB50_12595	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BBB50_12600	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BBB50_12625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BBB50_12630	COG0735	belongs to the Fur family
BBB50_12645	COG0166	Belongs to the GPI family
BBB50_12650	COG0432	Pfam Uncharacterised protein family UPF0047
BBB50_12655	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BBB50_12660	COG0305	Participates in initiation and elongation during chromosome replication
BBB50_12670	COG0359	binds to the 23S rRNA
BBB50_12675	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BBB50_12680	COG2965	DNA replication, synthesis of RNA primer
BBB50_12685	COG0360	Binds together with S18 to 16S ribosomal RNA
BBB50_12695	COG2906	2 iron, 2 sulfur cluster binding
BBB50_12700	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BBB50_12705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BBB50_12710	COG0049	tRNA binding
BBB50_12715	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BBB50_12725	COG2923	Belongs to the DsrF TusC family
BBB50_12730	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BBB50_12735	COG2964	Protein conserved in bacteria
BBB50_12740	COG0545	Peptidyl-prolyl cis-trans isomerase
BBB50_12750	COG2900	Belongs to the SlyX family
BBB50_12755	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
BBB50_12760	COG0330	HflC and HflK could
BBB50_12765	COG0330	HflC and HflK could
BBB50_12770	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BBB50_12775	COG1923	regulation of RNA biosynthetic process
BBB50_12780	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BBB50_12785	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BBB50_12795	COG0802	atpase or kinase
BBB50_12800	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BBB50_12845	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BBB50_12850	COG1162	GTPase activity
BBB50_12855	COG0688	phosphatidylethanolamine metabolic process
BBB50_12860	COG0471	metal ion transport
BBB50_12870	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BBB50_12875	COG4942	peptidase
BBB50_12890	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BBB50_12895	COG2816	NAD+ diphosphatase activity
BBB50_12900	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
BBB50_12905	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BBB50_12910	COG0085	RNA polymerase activity
BBB50_12915	COG0222	ribosome binding
BBB50_12920	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BBB50_12925	COG0081	regulation of translation
BBB50_12930	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BBB50_12935	COG0250	Participates in transcription elongation, termination and antitermination
BBB50_12940	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BBB50_12945	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BBB50_12970	COG1072	(Pantothenic acid kinase))
BBB50_12980	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BBB50_12995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BBB50_13045	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BBB50_13055	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BBB50_13060	COG3118	belongs to the thioredoxin family
BBB50_13065	COG0513	Belongs to the DEAD box helicase family
BBB50_13070	COG0248	Ppx GppA phosphatase
BBB50_13075	COG0784	Response regulator, receiver
BBB50_13075	COG2205	protein histidine kinase activity
BBB50_13080	COG2814	Major facilitator Superfamily
BBB50_13100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BBB50_13105	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BBB50_13110	COG0511	ligase activity, forming carbon-carbon bonds
BBB50_13115	COG0439	Biotin carboxylase
BBB50_13125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BBB50_13130	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BBB50_13135	COG1609	Transcriptional regulator
BBB50_13140	COG0129	dihydroxy-acid dehydratase activity
BBB50_13145	COG3265	gluconokinase activity
BBB50_13155	COG0800	Aldolase
BBB50_13170	COG0840	transmembrane signaling receptor activity
BBB50_13175	COG1982	Orn Lys Arg decarboxylase major
BBB50_13180	COG0531	amino acid
BBB50_13185	COG3710	Transcriptional regulator
BBB50_13190	COG0789	Transcriptional regulator
BBB50_13195	COG0138	bifunctional purine biosynthesis protein purh
BBB50_13200	COG0151	Belongs to the GarS family
BBB50_13210	COG0776	regulation of translation
BBB50_13220	COG1253	flavin adenine dinucleotide binding
BBB50_13225	COG1940	carbohydrate kinase activity
BBB50_13235	COG3068	Protein conserved in bacteria
BBB50_13245	COG1573	uracil-dna glycosylase
BBB50_13250	COG0668	transmembrane transport
BBB50_13255	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BBB50_13260	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BBB50_13290	COG5433	transposase activity
BBB50_13305	COG1012	belongs to the aldehyde dehydrogenase family
BBB50_13305	COG1454	alcohol dehydrogenase
BBB50_13310	COG0318	PFAM AMP-dependent synthetase and ligase
BBB50_13340	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
BBB50_13345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BBB50_13350	COG0662	Cupin 2, conserved barrel domain protein
BBB50_13350	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BBB50_13355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BBB50_13390	COG1519	Transferase
BBB50_13420	COG3642	lipopolysaccharide core region biosynthetic process
BBB50_13425	COG0859	PFAM glycosyl transferase family 9
BBB50_13430	COG0463	Glycosyl transferase, family 2
BBB50_13435	COG0859	PFAM glycosyl transferase family 9
BBB50_13440	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BBB50_13445	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BBB50_13455	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BBB50_13460	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BBB50_13475	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BBB50_13480	COG1309	transcriptional regulator
BBB50_13485	COG1560	Kdo2-lipid A biosynthetic process
BBB50_13490	COG1560	Kdo2-lipid A biosynthetic process
BBB50_13495	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BBB50_13500	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BBB50_13505	COG1561	YicC-like family, N-terminal region
BBB50_13515	COG1263	PTS System
BBB50_13515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BBB50_13520	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BBB50_13545	COG1120	ATPase activity
BBB50_13550	COG4774	siderophore transport
BBB50_13555	COG1132	(ABC) transporter
BBB50_13570	COG0514	ATP-dependent DNA helicase (RecQ)
BBB50_13575	COG2962	Rard protein
BBB50_13590	COG1280	lysine exporter protein (LysE YggA)
BBB50_13595	COG0210	DNA helicase
BBB50_13605	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BBB50_13610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BBB50_13620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBB50_13630	COG0747	negative chemotaxis
BBB50_13685	COG1309	transcriptional regulator
BBB50_13690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BBB50_13695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BBB50_13700	COG2960	long-chain fatty acid transporting porin activity
BBB50_13705	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BBB50_13710	COG0583	DNA-binding transcription factor activity
BBB50_13785	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
BBB50_13790	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BBB50_13795	COG1739	Uncharacterized protein family UPF0029
BBB50_13800	COG1250	3-hydroxyacyl-CoA dehydrogenase
BBB50_13800	COG1024	Enoyl-CoA hydratase
BBB50_13805	COG0183	Belongs to the thiolase family
BBB50_13810	COG0583	DNA-binding transcription factor activity
BBB50_13815	COG2814	Major facilitator Superfamily
BBB50_13825	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BBB50_13830	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BBB50_13835	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BBB50_13840	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BBB50_13845	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BBB50_13850	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BBB50_13860	COG0356	it plays a direct role in the translocation of protons across the membrane
BBB50_13865	COG3312	ion transport
BBB50_13870	COG1475	DNA binding
BBB50_13875	COG1192	Involved in chromosome partitioning
BBB50_13880	COG0357	Ribosomal RNA small subunit methyltransferase G
BBB50_13885	COG0445	tRNA wobble uridine modification
BBB50_13895	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BBB50_13900	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BBB50_13905	COG0706	membrane insertase activity
BBB50_13910	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BBB50_13915	COG0594	ribonuclease P activity
BBB50_13920	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BBB50_13925	COG1126	abc transporter atp-binding protein
BBB50_13960	COG0217	transcriptional regulatory protein
BBB50_13965	COG2084	Dehydrogenase
BBB50_13985	COG2909	trisaccharide binding
BBB50_13990	COG0058	SHG alpha-glucan phosphorylase activity
BBB50_13995	COG1640	4-alpha-glucanotransferase
BBB50_14000	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BBB50_14010	COG3501	Rhs element vgr protein
BBB50_14045	COG0471	metal ion transport
BBB50_14050	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
BBB50_14095	COG0671	phosphoesterase, PA-phosphatase related
BBB50_14100	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BBB50_14110	COG1999	signal sequence binding
BBB50_14125	COG0786	glutamate:sodium symporter activity
BBB50_14145	COG1566	PFAM secretion protein HlyD family protein
BBB50_14155	COG3706	GGDEF domain
BBB50_14170	COG0813	purine-nucleoside phosphorylase activity
BBB50_14180	COG3272	Protein of unknown function (DUF1722)
BBB50_14190	COG0415	Belongs to the DNA photolyase family
BBB50_14195	COG1376	ErfK ybiS ycfS ynhG family protein
BBB50_14195	COG1388	LysM domain
BBB50_14210	COG0513	Belongs to the DEAD box helicase family
BBB50_14215	COG1770	oligopeptidase
BBB50_14245	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BBB50_14250	COG0573	inorganic phosphate transmembrane transporter activity
BBB50_14255	COG0581	inorganic phosphate transmembrane transporter activity
BBB50_14260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BBB50_14280	COG0659	secondary active sulfate transmembrane transporter activity
BBB50_14290	COG0739	heme binding
BBB50_14295	COG3300	MHYT domain
BBB50_14295	COG5001	Diguanylate cyclase
BBB50_14300	COG0583	DNA-binding transcription factor activity
BBB50_14305	COG2814	Major facilitator Superfamily
BBB50_14330	COG1301	dicarboxylic acid transport
BBB50_14340	COG1342	Belongs to the UPF0251 family
BBB50_14375	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BBB50_14380	COG0673	inositol 2-dehydrogenase activity
BBB50_14390	COG2200	EAL domain
BBB50_14390	COG2771	luxR family
BBB50_14395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BBB50_14405	COG0564	pseudouridine synthase activity
BBB50_14500	COG3501	Rhs element vgr protein
BBB50_14520	COG1869	D-ribose catabolic process
BBB50_14525	COG1129	ABC transporter
BBB50_14530	COG1172	Belongs to the binding-protein-dependent transport system permease family
BBB50_14535	COG1879	ABC-type sugar transport system periplasmic component
BBB50_14540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BBB50_14545	COG1609	Transcriptional regulator
BBB50_14555	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
BBB50_14565	COG0584	glycerophosphoryl diester phosphodiesterase
BBB50_14570	COG2271	Major facilitator Superfamily
BBB50_14610	COG0579	oxidoreductase
BBB50_14620	COG0242	peptide deformylase activity
BBB50_14630	COG1320	monovalent cation:proton antiporter activity
BBB50_14635	COG2212	antiporter activity
BBB50_14655	COG2111	Na H antiporter
BBB50_14655	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BBB50_14665	COG0589	response to stress
BBB50_14670	COG0814	amino acid
BBB50_14675	COG3033	Beta-eliminating lyase
BBB50_14685	COG3530	Putative quorum-sensing-regulated virulence factor
BBB50_14695	COG5001	Diguanylate cyclase
BBB50_14695	COG5002	protein histidine kinase activity
BBB50_14700	COG1278	Cold shock
BBB50_14715	COG2304	oxidoreductase activity
BBB50_14735	COG0714	Associated with various cellular activities
BBB50_14740	COG0840	transmembrane signaling receptor activity
BBB50_14755	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BBB50_14760	COG2195	Cleaves the N-terminal amino acid of tripeptides
BBB50_14770	COG3604	Transcriptional regulator
BBB50_14775	COG1017	nitric oxide dioxygenase activity
BBB50_14775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BBB50_14780	COG1278	Cold shock
BBB50_14785	COG3036	rescue of stalled ribosome
BBB50_14810	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BBB50_14810	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BBB50_14815	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BBB50_14825	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BBB50_14840	COG0516	GMP reductase activity
BBB50_14865	COG1943	Transposase
BBB50_14870	COG0513	Belongs to the DEAD box helicase family
BBB50_14875	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BBB50_14880	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BBB50_14885	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BBB50_14895	COG3437	response regulator, receiver
BBB50_14895	COG0784	Response regulator, receiver
BBB50_14900	COG4191	Histidine kinase
BBB50_14900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBB50_14910	COG1757	Na H antiporter
BBB50_14915	COG2814	Major facilitator Superfamily
BBB50_14930	COG3706	GGDEF domain
BBB50_14935	COG3240	lipase activity
BBB50_14945	COG0840	transmembrane signaling receptor activity
BBB50_14950	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BBB50_14955	COG5380	lipid catabolic process
BBB50_14960	COG4412	M6 family metalloprotease domain protein
BBB50_14960	COG3291	Pkd domain containing protein
BBB50_14980	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBB50_14985	COG4605	iron ion homeostasis
BBB50_14990	COG4604	ABC transporter, ATP-binding protein
BBB50_15010	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BBB50_15030	COG0745	RESPONSE REGULATOR receiver
BBB50_15040	COG3623	hexulose-6-phosphate isomerase
BBB50_15045	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
BBB50_15050	COG0561	phosphatase activity
BBB50_15080	COG3038	cytochrome b561
BBB50_15085	COG0366	Alpha amylase catalytic
BBB50_15110	COG0745	RESPONSE REGULATOR receiver
BBB50_15115	COG5002	protein histidine kinase activity
BBB50_15140	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BBB50_15155	COG2814	Major facilitator Superfamily
BBB50_15160	COG1943	Transposase
BBB50_15175	COG1686	Belongs to the peptidase S11 family
BBB50_15190	COG3338	carbonate dehydratase activity
BBB50_15195	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BBB50_15195	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BBB50_15200	COG0509	glycine decarboxylation via glycine cleavage system
BBB50_15205	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BBB50_15215	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BBB50_15225	COG3039	Transposase
BBB50_15250	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BBB50_15260	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BBB50_15265	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BBB50_15275	COG0346	lactoylglutathione lyase activity
BBB50_15290	COG3549	Plasmid maintenance system killer
BBB50_15295	COG3093	addiction module antidote protein HigA
BBB50_15340	COG1619	proteins homologs of microcin C7 resistance protein MccF
BBB50_15360	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BBB50_15365	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BBB50_15380	COG3040	lipid binding
BBB50_15390	COG3041	Addiction module toxin RelE StbE family
BBB50_15450	COG0456	acetyltransferase
BBB50_15525	COG0456	acetyltransferase
BBB50_15550	COG0346	lactoylglutathione lyase activity
BBB50_15590	COG1619	proteins homologs of microcin C7 resistance protein MccF
BBB50_15625	COG1418	mRNA catabolic process
BBB50_15670	COG1619	proteins homologs of microcin C7 resistance protein MccF
BBB50_15705	COG3040	lipid binding
BBB50_15770	COG3549	Plasmid maintenance system killer
BBB50_15775	COG3093	addiction module antidote protein HigA
BBB50_15780	COG0384	phenazine biosynthesis protein PhzF
BBB50_15810	COG0346	lactoylglutathione lyase activity
BBB50_15830	COG3040	lipid binding
BBB50_15905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BBB50_15985	COG1619	proteins homologs of microcin C7 resistance protein MccF
BBB50_16005	COG3040	lipid binding
BBB50_16065	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BBB50_16070	COG4977	sequence-specific DNA binding
BBB50_16125	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
BBB50_16130	COG2944	sequence-specific DNA binding
BBB50_16145	COG3039	Transposase
BBB50_16165	COG0346	lactoylglutathione lyase activity
BBB50_16270	COG0346	lactoylglutathione lyase activity
BBB50_16290	COG1328	CTP reductase activity
BBB50_16295	COG0602	queuosine metabolic process
BBB50_16305	COG0189	ligase activity
BBB50_16305	COG4067	protein conserved in archaea
BBB50_16310	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BBB50_16310	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
BBB50_16310	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BBB50_16315	COG1105	Belongs to the carbohydrate kinase PfkB family
BBB50_16320	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBB50_16320	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBB50_16325	COG1609	Transcriptional regulator
BBB50_16330	COG0420	3'-5' exonuclease activity
BBB50_16335	COG0419	ATPase involved in DNA repair
BBB50_16340	COG2205	protein histidine kinase activity
BBB50_16340	COG0784	Response regulator, receiver
BBB50_16345	COG0156	8-amino-7-oxononanoate synthase activity
BBB50_16355	COG0038	chloride channel
BBB50_16360	COG0523	cobalamin synthesis protein
BBB50_16370	COG3158	transport of potassium into the cell
BBB50_16375	COG0674	pyruvate-flavodoxin oxidoreductase activity
BBB50_16375	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BBB50_16375	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BBB50_16375	COG1013	pyruvate-flavodoxin oxidoreductase activity
BBB50_16380	COG2205	protein histidine kinase activity
BBB50_16385	COG0745	RESPONSE REGULATOR receiver
BBB50_16390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BBB50_16395	COG0586	Pfam SNARE associated Golgi protein
BBB50_16405	COG2200	EAL domain
BBB50_16415	COG3038	cytochrome b561
BBB50_16425	COG2116	formate transmembrane transporter activity
BBB50_16430	COG0583	DNA-binding transcription factor activity
BBB50_16440	COG3593	DNA synthesis involved in DNA repair
BBB50_16445	COG0737	Belongs to the 5'-nucleotidase family
BBB50_16460	COG2824	Alkylphosphonate utilization operon protein PhnA
BBB50_16515	COG3706	GGDEF domain
BBB50_16530	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BBB50_16535	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BBB50_16545	COG0745	RESPONSE REGULATOR receiver
BBB50_16565	COG0023	Translation Initiation Factor
BBB50_16575	COG1181	Belongs to the D-alanine--D-alanine ligase family
BBB50_16585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BBB50_16585	COG1042	CoA-binding domain protein
BBB50_16585	COG0045	succinate-CoA ligase (ADP-forming) activity
BBB50_16590	COG0583	DNA-binding transcription factor activity
BBB50_16595	COG1629	transport
BBB50_16595	COG4771	TonB-dependent receptor
BBB50_16610	COG2050	protein possibly involved in aromatic compounds catabolism
BBB50_16630	COG0625	glutathione transferase activity
BBB50_16645	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BBB50_16650	COG4172	Belongs to the ABC transporter superfamily
BBB50_16655	COG4239	(ABC) transporter, permease
BBB50_16660	COG4174	ABC transporter (Permease)
BBB50_16665	COG4166	transmembrane transport
BBB50_16710	COG3842	ATPase activity
BBB50_16720	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BBB50_16730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BBB50_16735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BBB50_16740	COG1011	Hydrolase
BBB50_16750	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
BBB50_16755	COG1970	mechanosensitive ion channel activity
BBB50_16760	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BBB50_16765	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BBB50_16765	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BBB50_16770	COG0302	gtp cyclohydrolase
BBB50_16780	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BBB50_16790	COG2897	thiosulfate sulfurtransferase activity
BBB50_16795	COG2390	Transcriptional regulator
BBB50_16805	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BBB50_16810	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BBB50_16835	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BBB50_16860	COG0583	DNA-binding transcription factor activity
BBB50_16865	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BBB50_16870	COG0778	Nitroreductase
BBB50_16895	COG0640	Transcriptional regulator
BBB50_16905	COG0446	pyridine nucleotide-disulphide oxidoreductase
BBB50_16950	COG1263	PTS System
BBB50_16950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BBB50_16960	COG1621	beta-fructofuranosidase activity
BBB50_16965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BBB50_16970	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BBB50_16980	COG2885	chlorophyll binding
BBB50_16985	COG0545	Peptidyl-prolyl cis-trans isomerase
BBB50_16990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BBB50_16995	COG0840	transmembrane signaling receptor activity
BBB50_17005	COG3069	C4-dicarboxylate transmembrane transporter activity
BBB50_17010	COG1760	l-serine dehydratase
BBB50_17035	COG1609	Transcriptional regulator
BBB50_17040	COG2197	response regulator
BBB50_17045	COG3850	Histidine kinase
BBB50_17050	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BBB50_17060	COG0243	molybdopterin cofactor binding
BBB50_17080	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BBB50_17085	COG2197	response regulator
BBB50_17090	COG3851	Histidine kinase
BBB50_17095	COG2271	Major facilitator Superfamily
BBB50_17100	COG1840	ABC-type Fe3 transport system, periplasmic component
BBB50_17110	COG3842	ATPase activity
BBB50_17115	COG3243	poly(R)-hydroxyalkanoic acid synthase
BBB50_17125	COG0183	Belongs to the thiolase family
BBB50_17135	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BBB50_17140	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BBB50_17155	COG3706	GGDEF domain
BBB50_17160	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BBB50_17170	COG1979	alcohol dehydrogenase
BBB50_17185	COG4191	Histidine kinase
BBB50_17190	COG1840	ABC-type Fe3 transport system, periplasmic component
BBB50_17195	COG2271	Major facilitator Superfamily
BBB50_17200	COG0469	pyruvate kinase activity
BBB50_17205	COG0784	Response regulator, receiver
BBB50_17205	COG2205	protein histidine kinase activity
BBB50_17205	COG2198	Histidine kinase
BBB50_17210	COG1879	ABC-type sugar transport system periplasmic component
BBB50_17215	COG1803	Methylglyoxal synthase
BBB50_17220	COG1335	isochorismatase
BBB50_17225	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BBB50_17240	COG0210	DNA helicase
BBB50_17245	COG1289	transmembrane transporter activity
BBB50_17275	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BBB50_17280	COG4149	molybdate abc transporter
BBB50_17285	COG0725	ABC transporter, periplasmic molybdate-binding protein
BBB50_17290	COG1492	cobalamin metabolic process
BBB50_17335	COG0784	Response regulator, receiver
BBB50_17335	COG5002	protein histidine kinase activity
BBB50_17340	COG1879	ABC-type sugar transport system periplasmic component
BBB50_17350	COG2827	Endonuclease containing a URI domain
BBB50_17385	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BBB50_17395	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BBB50_17400	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
BBB50_17405	COG0247	lactate metabolic process
BBB50_17410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BBB50_17415	COG3118	belongs to the thioredoxin family
BBB50_17445	COG0583	DNA-binding transcription factor activity
BBB50_17450	COG4160	amino acid transport
BBB50_17455	COG4215	(ABC) transporter
BBB50_17460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBB50_17465	COG1126	abc transporter atp-binding protein
BBB50_17475	COG2425	protein containing a von Willebrand factor type A (vWA) domain
BBB50_17485	COG0494	nUDIX hydrolase
BBB50_17490	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
BBB50_17500	COG1309	transcriptional regulator
BBB50_17505	COG0513	Belongs to the DEAD box helicase family
BBB50_17510	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
BBB50_17520	COG0814	amino acid
BBB50_17555	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
BBB50_17565	COG1309	transcriptional regulator
BBB50_17570	COG0513	Belongs to the DEAD box helicase family
BBB50_17575	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
BBB50_17585	COG0814	amino acid
BBB50_17590	COG0840	transmembrane signaling receptor activity
BBB50_17595	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BBB50_17605	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BBB50_17615	COG1984	allophanate hydrolase subunit 2
BBB50_17630	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
BBB50_17635	COG4181	ATPase activity
BBB50_17645	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BBB50_17650	COG5001	Diguanylate cyclase
BBB50_17650	COG1716	ATPase activity
BBB50_17665	COG0484	heat shock protein binding
BBB50_17710	COG0546	phosphoglycolate phosphatase activity
BBB50_17725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BBB50_17730	COG1368	sulfuric ester hydrolase activity
BBB50_17740	COG0513	Belongs to the DEAD box helicase family
BBB50_17745	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
BBB50_17755	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BBB50_17765	COG3046	protein related to deoxyribodipyrimidine photolyase
BBB50_17770	COG3397	chitin binding
BBB50_17775	COG3227	Zinc metalloprotease (Elastase)
BBB50_17785	COG0010	Belongs to the arginase family
BBB50_17790	COG1166	arginine decarboxylase activity
BBB50_17800	COG2239	Acts as a magnesium transporter
BBB50_17805	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BBB50_17810	COG0459	protein refolding
BBB50_17820	COG0527	aspartate kinase activity
BBB50_17825	COG0662	Cupin 2, conserved barrel domain protein
BBB50_17830	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BBB50_17835	COG0456	acetyltransferase
BBB50_17840	COG2154	pterin-4-alpha-carbinolamine dehydratase
BBB50_17845	COG3186	Phenylalanine-4-hydroxylase
BBB50_17850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BBB50_17865	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BBB50_17870	COG0583	DNA-binding transcription factor activity
BBB50_17885	COG2171	N-acyltransferase activity
BBB50_17890	COG1253	flavin adenine dinucleotide binding
BBB50_17895	COG1765	OsmC-like protein
BBB50_17930	COG3706	GGDEF domain
BBB50_17940	COG3279	Response regulator of the LytR AlgR family
BBB50_17945	COG3275	phosphorelay sensor kinase activity
BBB50_17960	COG0577	efflux transmembrane transporter activity
BBB50_17960	COG1136	(ABC) transporter
BBB50_17965	COG1136	(ABC) transporter
BBB50_17980	COG4989	oxidoreductase activity
BBB50_17985	COG0366	Alpha amylase catalytic
BBB50_18000	COG2067	long-chain fatty acid transport protein
BBB50_18005	COG2267	carboxylic ester hydrolase activity
BBB50_18015	COG3227	Zinc metalloprotease (Elastase)
BBB50_18035	COG1686	Belongs to the peptidase S11 family
BBB50_18040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BBB50_18045	COG1271	oxidase subunit
BBB50_18050	COG1294	oxidase, subunit
BBB50_18060	COG3048	D-serine ammonia-lyase activity
BBB50_18065	COG0583	DNA-binding transcription factor activity
BBB50_18110	COG1063	alcohol dehydrogenase
BBB50_18120	COG2873	o-acetylhomoserine
BBB50_18130	COG0346	lactoylglutathione lyase activity
BBB50_18155	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BBB50_18160	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BBB50_18165	COG0363	glucosamine-6-phosphate deaminase activity
BBB50_18170	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BBB50_18195	COG1929	Belongs to the glycerate kinase type-1 family
BBB50_18200	COG2610	gluconate transmembrane transporter activity
BBB50_18205	COG3835	regulator
BBB50_18215	COG0748	coenzyme F420 binding
BBB50_18220	COG3721	Heme iron utilization protein
BBB50_18230	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
BBB50_18235	COG0811	peptide transport
BBB50_18240	COG0848	biopolymer transport protein
BBB50_18245	COG4558	Periplasmic binding protein
BBB50_18250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBB50_18255	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BBB50_18290	COG3217	Mosc domain protein beta barrel domain protein
BBB50_18290	COG0633	Ferredoxin
BBB50_18290	COG3217	Mosc domain protein beta barrel domain protein
BBB50_18290	COG0633	Ferredoxin
BBB50_18295	COG0418	dihydroorotase activity
BBB50_18305	COG3152	Membrane
BBB50_18315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BBB50_18320	COG2354	Protein conserved in bacteria
BBB50_18325	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BBB50_18330	COG1278	Cold shock
BBB50_18345	COG2207	Transcriptional regulator
BBB50_18345	COG4753	response regulator
BBB50_18355	COG3706	GGDEF domain
BBB50_18360	COG1349	DNA-binding transcription factor activity
BBB50_18375	COG3833	ABC-type maltose transport systems, permease component
BBB50_18380	COG1175	transmembrane transport
BBB50_18390	COG3842	ATPase activity
BBB50_18395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BBB50_18410	COG0393	Putative heavy-metal-binding
BBB50_18415	COG2197	response regulator
BBB50_18420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BBB50_18425	COG0784	Response regulator, receiver
BBB50_18425	COG0835	chemotaxis
BBB50_18430	COG1846	Transcriptional regulator
BBB50_18435	COG3706	GGDEF domain
BBB50_18475	COG0583	DNA-binding transcription factor activity
BBB50_18480	COG5001	Diguanylate cyclase
BBB50_18490	COG1741	Belongs to the pirin family
BBB50_18495	COG3123	guanosine phosphorylase activity
BBB50_18505	COG2211	Major facilitator Superfamily
BBB50_18515	COG0840	transmembrane signaling receptor activity
BBB50_18520	COG1067	ATP-dependent peptidase activity
BBB50_18530	COG4172	Belongs to the ABC transporter superfamily
BBB50_18550	COG0583	DNA-binding transcription factor activity
BBB50_18555	COG1620	l-lactate permease
BBB50_18560	COG1304	FMN binding
BBB50_18570	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BBB50_18580	COG0840	transmembrane signaling receptor activity
BBB50_18590	COG0513	Belongs to the DEAD box helicase family
BBB50_18595	COG0583	DNA-binding transcription factor activity
BBB50_18605	COG1902	pentaerythritol trinitrate reductase activity
BBB50_18615	COG1132	(ABC) transporter
BBB50_18625	COG1902	pentaerythritol trinitrate reductase activity
BBB50_18635	COG1280	lysine exporter protein (LysE YggA)
BBB50_18640	COG2207	Transcriptional regulator
BBB50_18660	COG1846	Transcriptional regulator
BBB50_18665	COG1764	response to oxidative stress
BBB50_18670	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BBB50_18675	COG0697	spore germination
BBB50_18685	COG0700	Nucleoside recognition
BBB50_18690	COG3366	ferrous iron transmembrane transporter activity
BBB50_18695	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BBB50_18705	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BBB50_18710	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BBB50_18715	COG2259	Doxx family
BBB50_18740	COG0363	glucosamine-6-phosphate deaminase activity
BBB50_18755	COG4580	involved in the transport of maltose and maltodextrins
BBB50_18770	COG0840	transmembrane signaling receptor activity
BBB50_18785	COG0840	transmembrane signaling receptor activity
BBB50_18795	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BBB50_18800	COG1126	abc transporter atp-binding protein
BBB50_18810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBB50_18815	COG4597	amino acid ABC transporter
BBB50_18820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BBB50_18830	COG0739	heme binding
BBB50_18840	COG2213	PTS system mannitol-specific
BBB50_18840	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBB50_18845	COG0246	Mannitol dehydrogenase
BBB50_18850	COG3722	fumarate hydratase activity
BBB50_18855	COG0673	inositol 2-dehydrogenase activity
BBB50_18885	COG2910	NAD(P)H-binding
BBB50_18895	COG0840	transmembrane signaling receptor activity
BBB50_18900	COG4221	oxidoreductase activity
BBB50_18910	COG1901	pseudouridine methyltransferase
BBB50_18915	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BBB50_18920	COG0531	amino acid
BBB50_18925	COG1982	Orn Lys Arg decarboxylase major
BBB50_18955	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BBB50_18980	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BBB50_18990	COG0259	pyridoxamine-phosphate oxidase activity
BBB50_19020	COG0745	RESPONSE REGULATOR receiver
BBB50_19040	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BBB50_19045	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BBB50_19050	COG0840	transmembrane signaling receptor activity
BBB50_19055	COG0835	chemotaxis
BBB50_19060	COG0835	chemotaxis
BBB50_19065	COG0643	Histidine kinase
BBB50_19065	COG2198	Histidine kinase
BBB50_19085	COG0601	transmembrane transport
BBB50_19090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBB50_19100	COG2194	sulfuric ester hydrolase activity
BBB50_19105	COG0642	Histidine kinase
BBB50_19110	COG0745	RESPONSE REGULATOR receiver
BBB50_19140	COG1444	tRNA N-acetyltransferase activity
BBB50_19145	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine