locus-tag class description ASZ82_00001 ENOG4105QTB Flavodoxin ASZ82_00002 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) ASZ82_00003 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins ASZ82_00004 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) ASZ82_00007 ENOG4105E5Q amino acid AbC transporter ASZ82_00008 ENOG4105EAB amino acid AbC transporter ASZ82_00010 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) ASZ82_00011 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) ASZ82_00012 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) ASZ82_00013 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ASZ82_00016 ENOG4108ZNX Heat shock protein ASZ82_00017 ENOG4105JKW Valine--pyruvate aminotransferase ASZ82_00018 ENOG4105C38 Glycyl-tRNA synthetase beta subunit ASZ82_00019 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit ASZ82_00022 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) ASZ82_00024 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family ASZ82_00025 ENOG4105C7B Threonine dehydratase ASZ82_00026 ENOG4105C01 Dihydroxy-acid dehydratase ASZ82_00027 ENOG4105CM2 brancheD-chain amino acid aminotransferase ASZ82_00030 ENOG4105C0P Mg chelatase subunit ChlI ASZ82_00031 ENOG4106HNH Acyl-transferase ASZ82_00032 ENOG4108Z33 Thiol disulfide Interchange Protein ASZ82_00033 ENOG4105E27 serine threonine protein kinase ASZ82_00035 ENOG4105PC1 Conserved Protein ASZ82_00037 ENOG4108N23 SpoOM-related protein ASZ82_00038 ENOG4108UT2 hemolysin iii ASZ82_00040 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) ASZ82_00041 ENOG4105C1A potassium transporter peripheral membrane ASZ82_00042 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B ASZ82_00043 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) ASZ82_00044 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) ASZ82_00045 ENOG4108WZM domain protein ASZ82_00046 ENOG4105C79 DNA protecting protein DprA ASZ82_00047 ENOG4108RPN Protein smg homolog ASZ82_00048 ENOG4108WI1 Dna topoisomerase ASZ82_00049 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit ASZ82_00050 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) ASZ82_00051 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) ASZ82_00052 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) ASZ82_00053 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) ASZ82_00054 ENOG4105E2X shikimate dehydrogenase ASZ82_00056 ENOG4108Z0R Transferase ASZ82_00064 ENOG4105WMR Protein CrcB homolog ASZ82_00065 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) ASZ82_00067 ENOG4105D06 uba thif-type nad fad binding protein ASZ82_00068 ENOG4105WHD thiamine biosynthesis protein ThiS ASZ82_00069 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) ASZ82_00070 ENOG4105D41 biosynthesis protein thiH ASZ82_00071 ENOG4105DC7 peptidase M24 ASZ82_00071 ENOG4105DC7 peptidase M24 ASZ82_00073 ENOG4105CNH Multidrug resistance protein MdtL ASZ82_00075 ENOG4108VVK transcriptional Regulator, AsnC ASZ82_00076 ENOG4105BZU Histidine kinase ASZ82_00077 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) ASZ82_00079 ENOG4105EMK carboxylate amino acid amine transporter ASZ82_00080 ENOG4108M6U Universal stress protein A ASZ82_00081 ENOG41090A1 ferritin ASZ82_00082 ENOG4108V6B universal stress protein B ASZ82_00083 ENOG4105CBX hi0933 family ASZ82_00085 ENOG4105CGY Dna recombination protein ASZ82_00086 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) ASZ82_00087 ENOG4105JC1 sterol-binding domain protein ASZ82_00088 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) ASZ82_00089 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) ASZ82_00090 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) ASZ82_00091 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) ASZ82_00092 ENOG4105CA0 peroxidase ASZ82_00093 ENOG4107R73 Mate efflux family protein ASZ82_00095 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) ASZ82_00096 ENOG4105E55 glycerol-3-phosphate acyltransferase ASZ82_00097 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) ASZ82_00098 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) ASZ82_00099 ENOG4105X6C Flagellar basal body-associated protein FliL ASZ82_00100 ENOG4105C8Q Methyl-accepting chemotaxis ASZ82_00102 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) ASZ82_00103 ENOG4105F8V Hydrolase, tatD family ASZ82_00105 ENOG4105D52 delta-aminolevulinic acid dehydratase ASZ82_00108 ENOG4105C2M dna polymerase I ASZ82_00110 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) ASZ82_00111 ENOG4106RE7 Cytochrome ASZ82_00113 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) ASZ82_00114 ENOG4105XCT Protein of unknown function (DUF2489) ASZ82_00115 ENOG4105D4P Coproporphyrinogen iii oxidase ASZ82_00116 ENOG410601J HemY protein ASZ82_00117 ENOG4105ECF c-methyltransferase ASZ82_00118 ENOG41076E6 Uroporphyrinogen-III Synthase ASZ82_00119 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) ASZ82_00120 ENOG4107T0K Adenylate cyclase ASZ82_00121 ENOG4105XQ6 frataxin-like protein ASZ82_00123 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) ASZ82_00124 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) ASZ82_00125 ENOG4105CT0 Protein of unknown function, DUF484 ASZ82_00126 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ASZ82_00127 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant ASZ82_00128 ENOG4105BZU Histidine kinase ASZ82_00131 ENOG4105DQF Hydrolase ASZ82_00132 ENOG4108EUD Lysophospholipase ASZ82_00133 ENOG410829K Lysine exporter protein (Lyse ygga) ASZ82_00134 ENOG4105D58 Diguanylate phosphodiesterase ASZ82_00136 ENOG4108RMU ferritin dps family protein ASZ82_00142 ENOG4106H78 methyltransferase ASZ82_00143 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ASZ82_00144 ENOG4105CAK Cell division ATP-binding protein ftsE ASZ82_00145 ENOG4105CRP Part of the ABC transporter FtsEX involved in ASZ82_00146 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ASZ82_00147 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) ASZ82_00150 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) ASZ82_00151 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) ASZ82_00152 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin ASZ82_00153 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) ASZ82_00160 ENOG4105EMY transcriptional regulator ASZ82_00161 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase ASZ82_00162 ENOG4105W0Z cytoplasmic protein ASZ82_00163 ENOG4105BZS acriflavin resistance protein ASZ82_00164 ENOG410624X efflux transporter, rnd family, mfp subunit ASZ82_00165 ENOG4105Y7M Transcriptional regulator, TetR family ASZ82_00166 ENOG4105C4R Atp-dependent dna helicase ASZ82_00167 ENOG4105MPD Cytochrome ASZ82_00175 ENOG4105DEF Extracellular solute-binding protein, family 5 ASZ82_00176 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ASZ82_00177 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ASZ82_00179 ENOG4108UK2 deaminase ASZ82_00182 ENOG4108ZXE ASZ82_00188 ENOG4105DC8 reductase ASZ82_00189 ENOG4105D6S protein involved in catabolism of external DNA ASZ82_00190 ENOG4105DGW oligopeptidase A ASZ82_00191 ENOG4105C4R Atp-dependent dna helicase ASZ82_00193 ENOG4108DMH HTH_ARAC ASZ82_00195 ENOG4105FR1 rard protein ASZ82_00197 ENOG4105C9U ATP-dependent DNA helicase RecQ ASZ82_00200 ENOG4105BZ1 (ABC) transporter ASZ82_00201 ENOG4105E0K tonB-dependent siderophore receptor ASZ82_00202 ENOG4105E0A ABC, transporter ASZ82_00203 ENOG4105J76 Periplasmic binding protein ASZ82_00204 ENOG4105S6R Iron-hydroxamate transporter permease subunit ASZ82_00205 ENOG4105S6R Iron-hydroxamate transporter permease subunit ASZ82_00206 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) ASZ82_00207 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate ASZ82_00208 ENOG4105C5Y PTS System ASZ82_00210 ENOG4105DSJ YicC domain protein ASZ82_00211 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) ASZ82_00212 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) ASZ82_00213 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase ASZ82_00214 ENOG4105D1S lipid A biosynthesis ASZ82_00215 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) ASZ82_00217 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase ASZ82_00218 ENOG4108NVR Methyl-accepting chemotaxis ASZ82_00221 ENOG4105KDC 50s ribosomal protein l28 ASZ82_00222 ENOG4105W0E 50S ribosomal protein L33 ASZ82_00224 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) ASZ82_00225 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) ASZ82_00226 ENOG4105M5K heptosyltransferase ASZ82_00227 ENOG4106WTF Glycosyl transferase, family 2 ASZ82_00228 ENOG4105DKP glycosyl transferase, family 9 ASZ82_00229 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) ASZ82_00235 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase ASZ82_00236 ENOG4108ST3 glycosyltransferase ASZ82_00238 ENOG4105XA0 heptosyltransferase ii ASZ82_00241 ENOG4107T94 Endo-14-beta-xylanase ASZ82_00242 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) ASZ82_00243 ENOG4105CJT Mannose-1-phosphate guanylyltransferase ASZ82_00244 ENOG4107QKV phosphomannomutase ASZ82_00245 ENOG4105C0K Gdp-mannose 4,6-dehydratase ASZ82_00246 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase ASZ82_00249 ENOG4105EY8 ABC transporter ASZ82_00251 ENOG4105CEY Amp-dependent synthetase and ligase ASZ82_00252 ENOG4108EKI Dehydrogenase ASZ82_00254 ENOG4108UT6 Transferase hexapeptide repeat containing protein ASZ82_00255 ENOG410600T transposase ASZ82_00256 ENOG410600T transposase ASZ82_00261 ENOG4105D3Q Sugar transferase ASZ82_00263 ENOG4105CY0 Metallo-Beta-Lactamase ASZ82_00264 ENOG4105CUY Mechanosensitive ion channel ASZ82_00265 ENOG4108RG0 uracil-dna glycosylase ASZ82_00266 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase ASZ82_00267 ENOG4105R2J Conserved Protein ASZ82_00268 ENOG4105EIP mannose-6-phosphate isomerase ASZ82_00269 ENOG4105DKQ ROK family ASZ82_00271 ENOG4105K70 DNA-binding protein ASZ82_00273 ENOG4105C12 Phosphoribosylglycinamide synthetase ASZ82_00274 ENOG4105DC1 bifunctional purine biosynthesis protein purh ASZ82_00276 ENOG4105W1Y Transcriptional regulator ASZ82_00277 ENOG4108M3R transcriptional activator CadC ASZ82_00278 ENOG4105D5Q Arginine ornithine antiporter ASZ82_00279 ENOG4105CXN decarboxylase ASZ82_00280 ENOG4105C8Q Methyl-accepting chemotaxis ASZ82_00283 ENOG4105E0K tonB-dependent siderophore receptor ASZ82_00284 ENOG4108UHU Aldolase ASZ82_00285 ENOG4105C6Z Gluconate ASZ82_00286 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family ASZ82_00287 ENOG4105C01 Dihydroxy-acid dehydratase ASZ82_00288 ENOG4105DIQ Transcriptional regulator ASZ82_00289 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) ASZ82_00290 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) ASZ82_00291 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) ASZ82_00292 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase ASZ82_00293 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein ASZ82_00294 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) ASZ82_00295 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ASZ82_00298 ENOG4105D8G Major Facilitator superfamily ASZ82_00299 ENOG4105BZU Histidine kinase ASZ82_00300 ENOG4105C9X ppx gppa phosphatase ASZ82_00301 ENOG4105C1J atp-dependent rna helicase ASZ82_00302 ENOG4105K63 Thioredoxin ASZ82_00303 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) ASZ82_00305 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) ASZ82_00307 ENOG4107QK7 reductase ASZ82_00314 ENOG4105JIM Phosphatidylserine synthase ASZ82_00316 ENOG4105D4A Cell wall formation (By similarity) ASZ82_00317 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase ASZ82_00318 ENOG4105CS9 pantothenic acid kinase ASZ82_00323 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) ASZ82_00324 ENOG4105PM1 preprotein translocase subunit SecE ASZ82_00325 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) ASZ82_00326 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) ASZ82_00327 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) ASZ82_00328 ENOG4108VZM 50s ribosomal protein L10 ASZ82_00329 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) ASZ82_00330 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ASZ82_00331 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ASZ82_00332 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor ASZ82_00333 ENOG4105E09 nadh pyrophosphatase ASZ82_00334 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) ASZ82_00335 ENOG41062JF Transcriptional regulator ASZ82_00337 ENOG41063SB peptidase ASZ82_00338 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) ASZ82_00340 ENOG4105C8P )-transporter ASZ82_00341 ENOG4105DJ4 phosphatidylserine decarboxylase ASZ82_00342 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) ASZ82_00343 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) ASZ82_00353 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) ASZ82_00354 ENOG4105K8N protein family UPF0079, ATPase ASZ82_00355 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase ASZ82_00356 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) ASZ82_00357 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) ASZ82_00358 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) ASZ82_00359 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) ASZ82_00360 ENOG4107QJR hflk protein ASZ82_00361 ENOG4105EPW hflc protein ASZ82_00363 ENOG41069P5 Protein slyX homolog ASZ82_00365 ENOG4108V1T peptidylprolyl cis-trans isomerase ASZ82_00366 ENOG4105WWK YheO domain protein ASZ82_00367 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) ASZ82_00368 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) ASZ82_00370 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) ASZ82_00371 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) ASZ82_00372 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) ASZ82_00373 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) ASZ82_00374 ENOG4105W53 bacterioferritin-associated ferredoxin ASZ82_00375 ENOG4108UQY Iron-storage protein ASZ82_00376 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) ASZ82_00377 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) ASZ82_00378 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) ASZ82_00379 ENOG4105K9Q Binds to the 23S rRNA (By similarity) ASZ82_00381 ENOG4105CDU Replicative dna helicase ASZ82_00382 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ASZ82_00383 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme ASZ82_00384 ENOG4107QP8 phosphohexose isomerase ASZ82_00387 ENOG4105MYN Zinc uptake regulation protein ASZ82_00388 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) ASZ82_00390 ENOG4105P4Z Phage shock protein G ASZ82_00394 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) ASZ82_00395 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) ASZ82_00396 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) ASZ82_00409 ENOG4105EEQ Na H antiporter ASZ82_00410 ENOG4105C3R Methionine synthase ASZ82_00411 ENOG4105CFH Aspartokinase ASZ82_00412 ENOG4105C5R Aminotransferase ASZ82_00414 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) ASZ82_00415 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase ASZ82_00416 ENOG41086KC Transcriptional regulator ASZ82_00417 ENOG4108UUM single-stranded DNA-binding protein ASZ82_00418 ENOG41062P1 Diguanylate cyclase phosphodiesterase ASZ82_00422 ENOG4105E4G Type IV pilus ASZ82_00425 ENOG4107QHF type ii secretion system protein e ASZ82_00426 ENOG4105D7Q type ii secretion system ASZ82_00435 ENOG4105DFF Rod shape-determining protein mreb ASZ82_00436 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) ASZ82_00437 ENOG4105VQ7 Rod shape-determining protein MreD ASZ82_00438 ENOG4108Z03 MAF-like protein ASZ82_00439 ENOG4105C03 ribonuclease ASZ82_00440 ENOG4105QD6 exported protein ASZ82_00442 ENOG4105D1U peptidase U62 modulator of DNA gyrase ASZ82_00443 ENOG4105CEU Arginine dihydrolase ASZ82_00447 ENOG41081QV Universal stress protein ASZ82_00450 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) ASZ82_00451 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) ASZ82_00452 ENOG4105D5Q Arginine ornithine antiporter ASZ82_00453 ENOG4105EAH synthase ASZ82_00454 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) ASZ82_00455 ENOG4105K46 50S ribosomal protein l27 ASZ82_00456 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control ASZ82_00457 ENOG4105DWK Membrane ASZ82_00458 ENOG4107XM3 UPF0442 protein ASZ82_00460 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) ASZ82_00461 ENOG4105NWN ApaG protein ASZ82_00462 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) ASZ82_00463 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) ASZ82_00464 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) ASZ82_00465 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) ASZ82_00466 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) ASZ82_00477 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division ASZ82_00478 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) ASZ82_00479 ENOG4105CEN a g-specific adenine glycosylase ASZ82_00481 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) ASZ82_00482 ENOG4105CSV Glutaminase ASZ82_00483 ENOG4105CSA Coproporphyrinogen iii oxidase ASZ82_00484 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) ASZ82_00486 ENOG4105VZ9 UPF0235 protein ASZ82_00487 ENOG4108VIA integral membrane protein ASZ82_00488 ENOG4105II7 pyrroline-5-carboxylate reductase ASZ82_00489 ENOG4105DFA alanine racemase domain protein ASZ82_00490 ENOG4105CZX twitching motility protein ASZ82_00491 ENOG4105CZX twitching motility protein ASZ82_00493 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) ASZ82_00494 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) ASZ82_00495 ENOG4108UJU UPF0301 protein ASZ82_00496 ENOG4105D7Z glutathione synthase ASZ82_00497 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) ASZ82_00498 ENOG4105RWS endonuclease I ASZ82_00499 ENOG4105GPY SprT protein ASZ82_00500 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP ASZ82_00502 ENOG4105CV1 Transketolase (EC 2.2.1.1) ASZ82_00503 ENOG4108R4R Iron-regulated virulence regulatory protein ASZ82_00504 ENOG4105D05 Receptor ASZ82_00505 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase ASZ82_00506 ENOG4105BZA Phosphoglycerate kinase ASZ82_00507 ENOG4105D2N Aldolase ASZ82_00508 ENOG4105D64 Mechanosensitive ion channel ASZ82_00509 ENOG4108ZUB Lysine exporter protein (Lyse ygga) ASZ82_00510 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) ASZ82_00511 ENOG4105MPN Membrane ASZ82_00513 ENOG4105CA9 Pyruvate kinase ASZ82_00514 ENOG410804X Transcriptional regulator ASZ82_00515 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) ASZ82_00516 ENOG4105CH5 extracellular solute-binding protein, family 7 ASZ82_00527 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) ASZ82_00535 ENOG4105DR5 peptidase ASZ82_00542 ENOG4108YGG dna repair protein ASZ82_00544 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor ASZ82_00546 ENOG4105C8Q Methyl-accepting chemotaxis ASZ82_00547 ENOG4105D58 Diguanylate phosphodiesterase ASZ82_00548 ENOG4105DFP Integrase ASZ82_00550 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ASZ82_00551 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) ASZ82_00552 ENOG4105KTH gatB Yqey ASZ82_00553 ENOG4105VCC 30S ribosomal protein S21 ASZ82_00555 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) ASZ82_00557 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) ASZ82_00558 ENOG4107ZVW dihydroneopterin aldolase ASZ82_00559 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase ASZ82_00560 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) ASZ82_00562 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) ASZ82_00563 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) ASZ82_00564 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) ASZ82_00565 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) ASZ82_00566 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) ASZ82_00567 ENOG4108K5P (LipO)protein ASZ82_00568 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ASZ82_00569 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) ASZ82_00570 ENOG4105C6T cysteine synthase ASZ82_00571 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein ASZ82_00572 ENOG4108I5D sulfate abc transporter ASZ82_00573 ENOG4105ECW sulfate abc transporter ASZ82_00574 ENOG4108IJ6 ABC transporter ASZ82_00576 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) ASZ82_00577 ENOG4105Y3E Modulates RecA activity (By similarity) ASZ82_00578 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) ASZ82_00580 ENOG4105CFH Aspartokinase ASZ82_00581 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) ASZ82_00591 ENOG4107QSA Oxaloacetate decarboxylase ASZ82_00592 ENOG4105D9Q decarboxylase (Beta subunit) ASZ82_00594 ENOG4105W39 Membrane ASZ82_00596 ENOG4105D9M gamma-glutamylcysteine synthetase ASZ82_00597 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) ASZ82_00598 ENOG4108JU6 CBS domain protein ASZ82_00599 ENOG4106KVJ cytochrome C assembly protein ASZ82_00600 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ASZ82_00601 ENOG4105K5M 30s ribosomal protein S16 ASZ82_00602 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) ASZ82_00603 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) ASZ82_00604 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) ASZ82_00605 ENOG4105C0H protease ASZ82_00606 ENOG4105C0H protease ASZ82_00608 ENOG4105D6Z AFG1 family ATPase ASZ82_00609 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) ASZ82_00610 ENOG4108UJD 30S ribosomal protein S9 ASZ82_00611 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) ASZ82_00612 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) ASZ82_00613 ENOG4105EIX cytochrome c1 ASZ82_00614 ENOG4107MKT Stringent starvation protein a ASZ82_00615 ENOG4105KB2 stringent starvation protein b ASZ82_00616 ENOG4105W4M Transport-associated protein ASZ82_00617 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) ASZ82_00618 ENOG41082RQ UPF0102 protein ASZ82_00619 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) ASZ82_00620 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) ASZ82_00621 ENOG410630P Transcriptional regulator ASZ82_00622 ENOG4108UGV hypoxanthine phosphoribosyltransferase ASZ82_00623 ENOG41077A9 carbonic anhydrase ASZ82_00624 ENOG4105CHH sulfate transporter ASZ82_00625 ENOG4105DA5 (ABC) transporter ASZ82_00626 ENOG4105E3A (ABC) transporter ASZ82_00627 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) ASZ82_00628 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) ASZ82_00629 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase ASZ82_00630 ENOG4105DJ0 Poly(A) Polymerase ASZ82_00631 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) ASZ82_00632 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters ASZ82_00633 ENOG4105PW4 Sugar fermentation stimulation protein homolog ASZ82_00635 ENOG4105CQ7 ATP-dependent helicase ASZ82_00636 ENOG4105BZ4 penicillin-binding protein ASZ82_00637 ENOG4105D78 K07001 NTE family protein ASZ82_00638 ENOG4107QIJ Aconitate hydratase 2 ASZ82_00639 ENOG4105XTV UPF0231 protein ASZ82_00640 ENOG4108YZA Nitrogen regulatory protein pii ASZ82_00644 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ASZ82_00646 ENOG4105E2V Glycosyltransferase 36 ASZ82_00647 ENOG4105E2D ec 3.2.1.52 ASZ82_00648 ENOG4105RD7 BadF BadG BcrA BcrD ASZ82_00650 ENOG4108JQ7 (ABC) transporter ASZ82_00651 ENOG4105C3U ABC transporter ASZ82_00652 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ASZ82_00654 ENOG4107QRA Extracellular solute-binding protein, family 5 ASZ82_00655 ENOG4105BZU Histidine kinase ASZ82_00656 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) ASZ82_00657 ENOG4105IPI Membrane ASZ82_00659 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase ASZ82_00661 ENOG4108YX9 iron--sulfur cluster insertion protein erpA ASZ82_00664 ENOG4105DR5 peptidase ASZ82_00665 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) ASZ82_00666 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase ASZ82_00667 ENOG4105FCK Membrane ASZ82_00668 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) ASZ82_00669 ENOG4105HBR Rna-binding protein ASZ82_00670 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) ASZ82_00671 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) ASZ82_00672 ENOG4105EEI dihydropteroate synthase ASZ82_00673 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) ASZ82_00677 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) ASZ82_00678 ENOG4105CHV Transcription elongation factor NusA ASZ82_00679 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) ASZ82_00680 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) ASZ82_00681 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) ASZ82_00682 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) ASZ82_00683 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) ASZ82_00684 ENOG4105RT1 May be involved in cell division (By similarity) ASZ82_00687 ENOG4106RZ4 Peptidase U32 ASZ82_00688 ENOG4105CFP Peptidase U32 ASZ82_00689 ENOG4105BZU Histidine kinase ASZ82_00690 ENOG4105XPQ lipid carrier protein ASZ82_00691 ENOG4108YYD acetyltransferase ASZ82_00694 ENOG4105BZU Histidine kinase ASZ82_00695 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) ASZ82_00696 ENOG4105C1J atp-dependent rna helicase ASZ82_00697 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) ASZ82_00698 ENOG4105CWM branched-chain amino acid transport system II carrier protein ASZ82_00699 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) ASZ82_00700 ENOG4105CRK lysyL-tRNA synthetase ASZ82_00701 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASZ82_00705 ENOG4105CPC Aldo Keto reductase ASZ82_00706 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) ASZ82_00709 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) ASZ82_00710 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase ASZ82_00711 ENOG4105HF0 Membrane ASZ82_00712 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) ASZ82_00713 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) ASZ82_00715 ENOG41063Z6 transcriptional regulator, lysR family ASZ82_00716 ENOG41080HT Transcriptional regulator, arsr family ASZ82_00717 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) ASZ82_00718 ENOG4105CJR Integral membrane protein (MviN ASZ82_00719 ENOG4105DTN riboflavin biosynthesis protein ribF ASZ82_00720 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) ASZ82_00721 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) ASZ82_00722 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase ASZ82_00723 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) ASZ82_00727 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate ASZ82_00728 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) ASZ82_00729 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) ASZ82_00730 ENOG4108NEV two component transcriptional regulator, LytTR family ASZ82_00731 ENOG4108HRK Histidine kinase ASZ82_00732 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) ASZ82_00735 ENOG4105C5H ABC transporter ASZ82_00736 ENOG4107SC1 transglycosylase ASZ82_00737 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) ASZ82_00738 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) ASZ82_00739 ENOG4108K0B C-di-gmp phosphodiesterase ASZ82_00740 ENOG4107XW0 Spermidine putrescine ABC transporter periplasmic spermidine putrescine-binding protein ASZ82_00742 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA ASZ82_00744 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane ASZ82_00745 ENOG4105C34 Pseudouridine synthase ASZ82_00746 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase ASZ82_00747 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ASZ82_00755 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding ASZ82_00756 ENOG4105CFP Peptidase U32 ASZ82_00757 ENOG4105DH7 May be involved in recombination (By similarity) ASZ82_00758 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ASZ82_00759 ENOG4105BZU Histidine kinase ASZ82_00761 ENOG4105C9X ppx gppa phosphatase ASZ82_00762 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) ASZ82_00763 ENOG4105C8U phosphate abc transporter ASZ82_00764 ENOG4105E2Z phosphate ABC transporter (Permease ASZ82_00765 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) ASZ82_00767 ENOG4105CSR polyphosphate kinase 2 ASZ82_00768 ENOG4106N3A copper homeostasis protein cutc ASZ82_00769 ENOG4105D3R alkyl hydroperoxide reductase ASZ82_00770 ENOG4105C5Q Transcriptional regulator ASZ82_00771 ENOG4107QP3 malate synthase g ASZ82_00772 ENOG4108I9X Isocitrate lyase ASZ82_00773 ENOG4105W87 Cbs domain ASZ82_00774 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) ASZ82_00775 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) ASZ82_00776 ENOG4105VIE preprotein translocase, subunit YajC ASZ82_00777 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ASZ82_00778 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ASZ82_00779 ENOG4105ECY inositol monophosphatase ASZ82_00780 ENOG4105CVS RNA methyltransferase TrmH family, group 1 ASZ82_00781 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family ASZ82_00782 ENOG4105C3J Cysteine desulfurase ASZ82_00783 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins ASZ82_00784 ENOG4108Z4V iron-sulfur cluster assembly ASZ82_00785 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) ASZ82_00786 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB ASZ82_00787 ENOG4108ZIT Ferredoxin, 2FE-2S ASZ82_00788 ENOG4105WVQ Fe-S assembly protein IscX ASZ82_00789 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) ASZ82_00790 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) ASZ82_00791 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs ASZ82_00793 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) ASZ82_00794 ENOG4105CUT histidyl-tRNA synthetase ASZ82_00795 ENOG4105N21 Membrane ASZ82_00796 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) ASZ82_00797 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) ASZ82_00800 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) ASZ82_00801 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) ASZ82_00802 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) ASZ82_00804 ENOG4106HK8 GPR1 FUN34 yaaH family protein ASZ82_00805 ENOG4105WQI isochorismatase ASZ82_00806 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase ASZ82_00807 ENOG4105E4F Isochorismate synthase ASZ82_00808 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase ASZ82_00810 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein ASZ82_00811 ENOG4105DQ5 transport system permease protein ASZ82_00812 ENOG4105TVJ transport system, permease ASZ82_00813 ENOG4105E0A ABC, transporter ASZ82_00815 ENOG41064T2 transcriptional regulator, lysR family ASZ82_00816 ENOG4105EUZ Beta-lactamase domain protein ASZ82_00817 ENOG4105BZG amino acid carrier protein ASZ82_00818 ENOG4105MWK D-amino acid dehydrogenase, small subunit ASZ82_00822 ENOG4106YYS transcriptional regulatory protein ASZ82_00823 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism ASZ82_00824 ENOG4105D9Q decarboxylase (Beta subunit) ASZ82_00825 ENOG4107QSA Oxaloacetate decarboxylase ASZ82_00828 ENOG4105DUA (citrate (pro-3S)-lyase ligase ASZ82_00829 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) ASZ82_00830 ENOG4105CI0 Citrate lyase ASZ82_00831 ENOG4105CHY citrate lyase, alpha ASZ82_00832 ENOG4105YGP holo-ACP synthase CitX ASZ82_00833 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase ASZ82_00836 ENOG4108Z4U Ferredoxin ASZ82_00837 ENOG4105DZ0 fad dependent oxidoreductase ASZ82_00849 ENOG4105C26 Dehydrogenase ASZ82_00853 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) ASZ82_00854 ENOG4107RK6 Methyl-accepting chemotaxis ASZ82_00857 ENOG4105XB6 Toxin coregulated pilin ASZ82_00860 ENOG4105GRU toxin co-regulated pilus biosynthesis outer membrane protein C ASZ82_00864 ENOG4107QHF type ii secretion system protein e ASZ82_00865 ENOG4108VEY type ii secretion system ASZ82_00868 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) ASZ82_00869 ENOG4105C8Q Methyl-accepting chemotaxis ASZ82_00871 ENOG4105DR5 peptidase ASZ82_00873 ENOG4105F88 accessory colonization factor AcfD ASZ82_00875 ENOG4105DFP Integrase ASZ82_00876 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) ASZ82_00877 ENOG4108Z1B Cyclase dehydrase ASZ82_00878 ENOG4105VDB UPF0125 protein ASZ82_00879 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) ASZ82_00880 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) ASZ82_00881 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) ASZ82_00882 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ ASZ82_00884 ENOG4105CFG Acts as a chaperone (By similarity) ASZ82_00885 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) ASZ82_00891 ENOG4105CFC Transporter ASZ82_00892 ENOG4108Z6B deaminase ASZ82_00894 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) ASZ82_00897 ENOG4107QIK phosphoribosylformylglycinamidine synthase ASZ82_00901 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) ASZ82_00902 ENOG4108R96 Methyltransferase, YaeB family ASZ82_00903 ENOG4105NRA 50s ribosomal protein l31 type b ASZ82_00905 ENOG4105CFC Transporter ASZ82_00906 ENOG4108UPT UPF0178 protein ASZ82_00908 ENOG4108428 Inherit from COG: -acetyltransferase ASZ82_00911 ENOG4105WP7 tRNA pseudouridine synthase C ASZ82_00912 ENOG4105DR9 pseudouridine synthase ASZ82_00913 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) ASZ82_00914 ENOG4105CTB Polyprenyl synthetase ASZ82_00916 ENOG4105E14 MotA TolQ exbB proton channel ASZ82_00918 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) ASZ82_00919 ENOG4105ETT transcriptional Regulator, LysR family ASZ82_00920 ENOG4105M08 Membrane ASZ82_00921 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease ASZ82_00922 ENOG4105EWT decarboxylase family ASZ82_00923 ENOG4105BZU Histidine kinase ASZ82_00925 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) ASZ82_00926 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) ASZ82_00927 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein ASZ82_00928 ENOG4105D01 (LipO)protein ASZ82_00929 ENOG4108UMI ABC transporter, permease ASZ82_00930 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) ASZ82_00931 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase ASZ82_00932 ENOG4105D4X repressor ASZ82_00933 ENOG4105C5Y PTS System ASZ82_00934 ENOG4105CG3 alpha amylase, catalytic region ASZ82_00940 ENOG4105BZS acriflavin resistance protein ASZ82_00941 ENOG4107ZF2 Phosphatase ASZ82_00942 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase ASZ82_00944 ENOG4108UW5 maltose o-acetyltransferase ASZ82_00948 ENOG4105D7W serine acetyltransferase ASZ82_00950 ENOG4105Q84 sucrose synthase ASZ82_00952 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family ASZ82_00955 ENOG4108MA4 Peptidase M66 ASZ82_00958 ENOG4105D3Q Sugar transferase ASZ82_00960 ENOG4105DAY polysaccharide export protein ASZ82_00961 ENOG4105D75 Capsular exopolysaccharide family ASZ82_00966 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) ASZ82_00968 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) ASZ82_00969 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) ASZ82_00970 ENOG4108Z43 UPF0250 protein ASZ82_00971 ENOG4105DZ1 carboxypeptidase ASZ82_00972 ENOG4105K6T rare lipoprotein A ASZ82_00973 ENOG4105CNI cell division protein FtsW ASZ82_00974 ENOG4105CJN penicillin-binding protein ASZ82_00975 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) ASZ82_00976 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) ASZ82_00977 ENOG4105DJF DNA polymerase III, delta' subunit ASZ82_00978 ENOG4108U2H Rare lipoprotein B ASZ82_00979 ENOG4105C8T Leucyl-tRNA synthetase ASZ82_00980 ENOG4107PAI alpha helical protein ASZ82_00981 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) ASZ82_00982 ENOG4108JU5 Magnesium and cobalt efflux protein ASZ82_00983 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) ASZ82_00984 ENOG4105C9A Phoh family ASZ82_00985 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) ASZ82_00986 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family ASZ82_00987 ENOG4105C5Y PTS System ASZ82_00989 ENOG4105KZ7 phosphocarrier protein hpr ASZ82_00990 ENOG4105C6T cysteine synthase ASZ82_00991 ENOG4105EXN Sulfate transport protein CysZ ASZ82_00992 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) ASZ82_00993 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) ASZ82_00994 ENOG41081QG Porin Gram-negative type ASZ82_00996 ENOG4108Z6Z Transcriptional regulator ASZ82_00997 ENOG4105G5H Membrane ASZ82_00998 ENOG4107QX8 SPFH domain, Band 7 family protein ASZ82_00999 ENOG4107QR8 Thioredoxin ASZ82_01001 ENOG4105E1F short-chain dehydrogenase reductase ASZ82_01002 ENOG4105ECP epimerase ASZ82_01003 ENOG4108RE9 Phosphodiesterase ASZ82_01006 ENOG4108TU9 TRANSCRIPTIONal ASZ82_01007 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) ASZ82_01008 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) ASZ82_01009 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) ASZ82_01010 ENOG4105DUX Transporter ASZ82_01012 ENOG4105MDZ Transcriptional activator rfaH ASZ82_01013 ENOG4105CAQ asparagine synthetase ASZ82_01014 ENOG4105CKD glutathione-regulated potassium-efflux system protein ASZ82_01015 ENOG4105E2R ROK family ASZ82_01016 ENOG4105CE4 GlcNAc 6-P deacetylase ASZ82_01017 ENOG4105CI1 PTS System ASZ82_01018 ENOG4105CX6 glutaminyL-tRNA synthetase ASZ82_01021 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) ASZ82_01022 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) ASZ82_01023 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase ASZ82_01024 ENOG4108S3P Sporulation domain protein ASZ82_01025 ENOG4105E96 Colicin v production protein ASZ82_01026 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase ASZ82_01027 ENOG4105D3Y Na H antiporter ASZ82_01028 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) ASZ82_01030 ENOG4105EIY sodium-type flagellar protein motY ASZ82_01031 ENOG4106WH9 Protein of unknown function (DUF2753) ASZ82_01032 ENOG4108UYE Lactoylglutathione lyase ASZ82_01033 ENOG4105CSM endonuclease III ASZ82_01034 ENOG4105DZB Electron transport complex ASZ82_01035 ENOG4108UQQ Electron transport complex ASZ82_01036 ENOG4105D6A Electron transport complex ASZ82_01038 ENOG4108R3D Electron transport complex ASZ82_01041 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) ASZ82_01042 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASZ82_01044 ENOG4105CHW UPF0052 protein ASZ82_01045 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) ASZ82_01046 ENOG4108RIR Molybdenum cofactor biosynthesis protein ASZ82_01047 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) ASZ82_01048 ENOG4105M00 molybdopterin converting factor, subunit 1 ASZ82_01049 ENOG4108ZAF Molybdopterin ASZ82_01050 ENOG4105BZU Histidine kinase ASZ82_01053 ENOG4108I5U Uridine phosphorylase ASZ82_01055 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) ASZ82_01056 ENOG4105D1F ATP-binding protein ASZ82_01057 ENOG4105DBI uridine monophosphokinase ASZ82_01058 ENOG4108GAE asmA family ASZ82_01059 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase ASZ82_01061 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation ASZ82_01062 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation ASZ82_01065 ENOG4105CHU acetyl-coa acetyltransferase ASZ82_01066 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ASZ82_01067 ENOG41069NU Nitroreductase ASZ82_01068 ENOG4105EJC lysr family transcriptional regulator ASZ82_01069 ENOG4105I93 response regulator ASZ82_01072 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) ASZ82_01073 ENOG4107QMP dna polymerase iii subunits gamma and tau ASZ82_01074 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) ASZ82_01075 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) ASZ82_01076 ENOG4105KRS Proteinase inhibitor ASZ82_01078 ENOG4105UBK short-chain dehydrogenase reductase ASZ82_01079 ENOG4105ERU peptidase ASZ82_01081 ENOG4108XM1 transcriptional regulator AsnC family ASZ82_01082 ENOG4105C29 acyl-CoA thioesterase ASZ82_01086 ENOG4105BZU Histidine kinase ASZ82_01087 ENOG41082YX Transcriptional regulator, arsr family ASZ82_01088 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase ASZ82_01094 ENOG4108V1U phospholipid-binding protein ASZ82_01098 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) ASZ82_01101 ENOG4107YTP response regulator receiver protein ASZ82_01103 ENOG4105BZU Histidine kinase ASZ82_01104 ENOG4105BZU Histidine kinase ASZ82_01105 ENOG4105BZU Histidine kinase ASZ82_01106 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASZ82_01109 ENOG4107QSI ABC, transporter ASZ82_01110 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ASZ82_01111 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ASZ82_01112 ENOG4105C3U ABC transporter ASZ82_01113 ENOG4108JQ7 (ABC) transporter ASZ82_01114 ENOG4105CHF Glutathione S-transferase ASZ82_01115 ENOG4108DNC Involved in acetate metabolism (By similarity) ASZ82_01116 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) ASZ82_01117 ENOG4105PQ6 UPF0208 membrane protein ASZ82_01118 ENOG4105VYA Uncharacterized conserved protein (DUF2132) ASZ82_01120 ENOG4105C7J ABC transporter, permease ASZ82_01121 ENOG4108JJB ABC transporter ASZ82_01122 ENOG4105BZU Histidine kinase ASZ82_01123 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) ASZ82_01124 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving ASZ82_01126 ENOG4105D1H recombination factor protein RarA ASZ82_01127 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) ASZ82_01128 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) ASZ82_01129 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) ASZ82_01130 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) ASZ82_01131 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) ASZ82_01132 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) ASZ82_01134 ENOG4105D0M Protease HtpX homolog ASZ82_01136 ENOG4107FW0 short-chain dehydrogenase reductase ASZ82_01139 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase ASZ82_01141 ENOG4105RHG ASZ82_01143 ENOG4107QTF adenylosuccinate lyase ASZ82_01144 ENOG41075W9 High frequency lysogenization protein HflD homolog ASZ82_01145 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) ASZ82_01146 ENOG4107RE1 Inosine-guanosine kinase ASZ82_01148 ENOG4107S6Z Na H antiporter ASZ82_01149 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) ASZ82_01150 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) ASZ82_01151 ENOG4105CIH Imidazole acetol-phosphate transaminase ASZ82_01152 ENOG4105ECC imidazole-glycerol-phosphate dehydratase ASZ82_01153 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) ASZ82_01154 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase ASZ82_01155 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) ASZ82_01156 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase ASZ82_01157 ENOG4108R99 pseudouridine synthase ASZ82_01159 ENOG4105VEQ Cold shock protein ASZ82_01160 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) ASZ82_01161 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ASZ82_01163 ENOG41090BQ Glutaredoxin ASZ82_01164 ENOG4108EKI Dehydrogenase ASZ82_01165 ENOG4106KNT transcriptional regulator ASZ82_01166 ENOG4105DY8 decarboxylase ASZ82_01168 ENOG4105DWU Membrane ASZ82_01173 ENOG4105CUX Signal transduction histidine kinase ASZ82_01175 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) ASZ82_01178 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) ASZ82_01179 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) ASZ82_01180 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) ASZ82_01181 ENOG41081XQ Conserved Protein ASZ82_01182 ENOG4105C9M aspartyl-trna synthetase ASZ82_01183 ENOG4107104 thymidine kinase ASZ82_01184 ENOG4105CK2 sodium dicarboxylate symporter ASZ82_01185 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) ASZ82_01186 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) ASZ82_01187 ENOG4105DK0 Indole-3-glycerol phosphate synthase ASZ82_01188 ENOG4108I0Q anthranilate phosphoribosyltransferase ASZ82_01189 ENOG4105DDQ anthranilate synthase ASZ82_01190 ENOG4105CRQ synthase (Component I) ASZ82_01192 ENOG4105DB7 PHP domain protein ASZ82_01193 ENOG4107RTD sua5 ycio yrdc ywlc family protein ASZ82_01194 ENOG4105FE9 pseudouridine synthase ASZ82_01195 ENOG4108JJ8 (ABC) transporter ASZ82_01196 ENOG4108JJ9 ABC, transporter ASZ82_01197 ENOG4105C3M thioredoxin reductase ASZ82_01199 ENOG4105C9B Cysteine desulfurase ASZ82_01200 ENOG4105BZU Histidine kinase ASZ82_01201 ENOG4107GZ4 SanA protein ASZ82_01203 ENOG4107R1I NAD-dependent malic enzyme ASZ82_01205 ENOG4105C8V SAICAR synthetase ASZ82_01209 ENOG4108ZG0 Ompa motb domain protein ASZ82_01212 ENOG4105CQB FAD linked oxidase domain protein ASZ82_01214 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap ASZ82_01216 ENOG4105C84 Histidine ammonia-lyase ASZ82_01217 ENOG4105CGP Urocanate hydratase ASZ82_01218 ENOG41088SP formiminoglutamate hydrolase ASZ82_01219 ENOG4105CI2 imidazolone-5-propionate hydrolase ASZ82_01220 ENOG4105CZE histidine utilization repressor ASZ82_01223 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) ASZ82_01225 ENOG4105BZU Histidine kinase ASZ82_01226 ENOG4105CQ2 DNA polymerase ASZ82_01227 ENOG4105WH1 Two component transcriptional regulator luxr family ASZ82_01228 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) ASZ82_01234 ENOG4105BZU Histidine kinase ASZ82_01237 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) ASZ82_01238 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) ASZ82_01240 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) ASZ82_01243 ENOG4105FQ6 thiopurine methyltransferase ASZ82_01244 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR ASZ82_01246 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) ASZ82_01247 ENOG41067MG lrgb family ASZ82_01249 ENOG4105CJB Exodeoxyribonuclease I ASZ82_01250 ENOG4108ETY sodium dicarboxylate symporter ASZ82_01251 ENOG4105E0X reductase ASZ82_01253 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) ASZ82_01254 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) ASZ82_01255 ENOG4108YZT Adenosylcobinamide kinase ASZ82_01258 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) ASZ82_01259 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) ASZ82_01262 ENOG4105C8Q Methyl-accepting chemotaxis ASZ82_01267 ENOG4107QK7 reductase ASZ82_01268 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ASZ82_01269 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ASZ82_01270 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) ASZ82_01271 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ASZ82_01272 ENOG4105C72 UPF0176 protein ASZ82_01274 ENOG4105S8Q sugar efflux transporter ASZ82_01276 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) ASZ82_01281 ENOG4105DIT ErfK YbiS YcfS YnhG family protein ASZ82_01282 ENOG4105EAQ (twin-arginine translocation) pathway signal ASZ82_01283 ENOG4105C5X domain protein ASZ82_01286 ENOG4105CH5 extracellular solute-binding protein, family 7 ASZ82_01288 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ASZ82_01291 ENOG41067TZ transcriptional regulator, MarR family ASZ82_01292 ENOG4105C94 Transporter ASZ82_01294 ENOG4105VZJ PTS System ASZ82_01296 ENOG4105VCP PTS System ASZ82_01297 ENOG4105F8D glycoside hydrolase family 4 ASZ82_01298 ENOG410901P UPF0249 protein ASZ82_01299 ENOG41060NJ transcriptional regulator ASZ82_01300 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) ASZ82_01301 ENOG4105DJ9 glucan biosynthesis protein ASZ82_01302 ENOG4105C8Q Methyl-accepting chemotaxis ASZ82_01306 ENOG4105CGF Aromatic amino acid aminotransferase ASZ82_01308 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase ASZ82_01310 ENOG4105C5S asparaginyl-tRNA synthetase ASZ82_01311 ENOG4108NVR Methyl-accepting chemotaxis ASZ82_01312 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase ASZ82_01313 ENOG4105EJQ L-serine dehydratase ASZ82_01314 ENOG4105C44 Serine transporter ASZ82_01315 ENOG4105P8F nudix hydrolase ASZ82_01316 ENOG4105CRQ synthase (Component I) ASZ82_01319 ENOG4105CM6 amino acid regulated cytosolic protein ASZ82_01321 ENOG4108JU8 Transcriptional regulator ASZ82_01322 ENOG4105D9U N-acetyltransferase ASZ82_01325 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ASZ82_01326 ENOG4108NVR Methyl-accepting chemotaxis ASZ82_01327 ENOG4105C8P )-transporter ASZ82_01328 ENOG4105BZU Histidine kinase ASZ82_01329 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASZ82_01330 ENOG4108MJ5 VirK protein ASZ82_01331 ENOG4105RW8 MltA-interacting MipA family protein ASZ82_01332 ENOG4105EB3 Histidine kinase ASZ82_01333 ENOG4107EXC regulatoR ASZ82_01339 ENOG4105C2J ABC transporter ASZ82_01340 ENOG4107SDZ Galactoside transport system permease protein mglC ASZ82_01346 ENOG41073TP transcriptional regulator ASZ82_01347 ENOG4105CR4 methylisocitrate lyase ASZ82_01348 ENOG4105BZN citrate synthase ASZ82_01349 ENOG4108I0Z Aconitate hydratase ASZ82_01350 ENOG4105C7F AcnD-accessory protein PrpF ASZ82_01351 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ASZ82_01354 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) ASZ82_01355 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase ASZ82_01356 ENOG4105F1J Homogentisate 1,2-dioxygenase ASZ82_01358 ENOG4108RXX maleylacetoacetate isomerase ASZ82_01359 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase ASZ82_01360 ENOG4105BZU Histidine kinase ASZ82_01362 ENOG4106TD9 Diguanylate cyclase ASZ82_01363 ENOG4105DR4 Methyltransferase ASZ82_01364 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 ASZ82_01365 ENOG4108Z0T Part of a sulfur-relay system (By similarity) ASZ82_01366 ENOG4108MN8 Membrane ASZ82_01367 ENOG4105CDA abc transporter atp-binding protein ASZ82_01368 ENOG4105DRP amino acid AbC transporter ASZ82_01369 ENOG4105EZ7 amino acid ABC transporter ASZ82_01370 ENOG4107QXX ABC transporter ASZ82_01372 ENOG410667J hydrolase ASZ82_01373 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) ASZ82_01374 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) ASZ82_01378 ENOG4105BZU Histidine kinase ASZ82_01380 ENOG4105BZU Histidine kinase ASZ82_01381 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB ASZ82_01382 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB ASZ82_01384 ENOG4105BZU Histidine kinase ASZ82_01390 ENOG4105CQ7 ATP-dependent helicase ASZ82_01392 ENOG4105R8A Heat shock protein ASZ82_01393 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) ASZ82_01395 ENOG4105EJC lysr family transcriptional regulator ASZ82_01396 ENOG4105C0R drug resistance transporter emrb qaca subfamily ASZ82_01397 ENOG4105CVP deoxyribo-dipyrimidine photolyase ASZ82_01398 ENOG4105KPY Small multidrug resistance protein ASZ82_01399 ENOG4108NVR Methyl-accepting chemotaxis ASZ82_01400 ENOG4108VYJ response regulator receiver protein ASZ82_01402 ENOG4105CBS Chea signal transduction histidine kinase ASZ82_01403 ENOG4105CBS Chea signal transduction histidine kinase ASZ82_01404 ENOG4105BZU Histidine kinase ASZ82_01406 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) ASZ82_01407 ENOG4108V3W Chemotaxis protein, CheW ASZ82_01408 ENOG4105C8Q Methyl-accepting chemotaxis ASZ82_01410 ENOG4108N3W hemolysin secretion protein ASZ82_01411 ENOG4107SDU Methyl-accepting chemotaxis ASZ82_01412 ENOG4105C1J atp-dependent rna helicase ASZ82_01414 ENOG4105ENJ RND efflux system, outer membrane lipoprotein ASZ82_01415 ENOG4105CW7 secretion protein, HlyD family ASZ82_01416 ENOG4105C0R drug resistance transporter emrb qaca subfamily ASZ82_01417 ENOG4105C8Q Methyl-accepting chemotaxis ASZ82_01418 ENOG4105CTD carboxy-peptidase ASZ82_01419 ENOG4108WC9 type VI secretion system effector, hcp1 family ASZ82_01420 ENOG4105CS6 Rhs element vgr protein ASZ82_01425 ENOG410829K Lysine exporter protein (Lyse ygga) ASZ82_01426 ENOG4105BZG amino acid carrier protein ASZ82_01429 ENOG4107RUE extracellular solute-binding protein family 1 ASZ82_01430 ENOG4107RUE extracellular solute-binding protein family 1 ASZ82_01431 ENOG4105D38 putrescine abc transporter ASZ82_01432 ENOG4105F38 ABC transporter, permease ASZ82_01433 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ASZ82_01437 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) ASZ82_01438 ENOG4105Q9Y Universal stress protein ASZ82_01439 ENOG4105DS0 Transcriptional regulator, Crp Fnr family ASZ82_01442 ENOG4105C59 p-type ATPase ASZ82_01444 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) ASZ82_01447 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i ASZ82_01449 ENOG4105BZU Histidine kinase ASZ82_01454 ENOG4108RC6 RTX toxin ASZ82_01455 ENOG4105EUK rtx toxin RtxA ASZ82_01456 ENOG4107927 Cholera enterotoxin, A subunit ASZ82_01457 ENOG4105MQ5 zona occludens toxin ASZ82_01481 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) ASZ82_01482 ENOG4105DAN ATP-dependent protease ASZ82_01483 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) ASZ82_01485 ENOG4105C5H ABC transporter ASZ82_01487 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) ASZ82_01489 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) ASZ82_01490 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) ASZ82_01491 ENOG4105C7I Dehydrogenase ASZ82_01493 ENOG4105CD8 aminopeptidase N ASZ82_01495 ENOG4105CN1 protease ASZ82_01496 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) ASZ82_01497 ENOG4108ZGC gaf domain protein ASZ82_01498 ENOG4105BZ1 (ABC) transporter ASZ82_01499 ENOG4105H2K paraquat-inducible protein a ASZ82_01500 ENOG4105DY2 Paraquat-inducible protein b ASZ82_01501 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B ASZ82_01502 ENOG4105QNR S1 RNA binding domain protein ASZ82_01505 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) ASZ82_01507 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) ASZ82_01510 ENOG4105QAX Iron-sulfur ASZ82_01511 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ASZ82_01513 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) ASZ82_01517 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) ASZ82_01518 ENOG4105C5H ABC transporter ASZ82_01519 ENOG4105BZU Histidine kinase ASZ82_01520 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASZ82_01522 ENOG4107A5B Binding-protein-dependent transport systems, inner membrane component ASZ82_01523 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ASZ82_01524 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) ASZ82_01525 ENOG4105CVM Molybdenum cofactor synthesis domain protein ASZ82_01530 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) ASZ82_01531 ENOG4106IUH DTW domain containing protein ASZ82_01533 ENOG4105C8Q Methyl-accepting chemotaxis ASZ82_01534 ENOG4107TT5 NLP P60 protein ASZ82_01536 ENOG4105FGM Fructosamine kinase ASZ82_01538 ENOG4107QI1 Mate efflux family protein ASZ82_01542 ENOG41067XB TonB family ASZ82_01543 ENOG4109015 Biopolymer transport protein exbD tolR ASZ82_01549 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component ASZ82_01550 ENOG4108IJ9 (ABC) transporter ASZ82_01551 ENOG4105E98 transcriptional regulator DeoR family ASZ82_01552 ENOG4107VXM glycerophosphoryl diester phosphodiesterase ASZ82_01553 ENOG4105XEP YhcH YjgK YiaL family protein ASZ82_01554 ENOG4105M4H endoribonuclease L-psp ASZ82_01556 ENOG4105DDV Transcriptional regulator (LacI family ASZ82_01557 ENOG4105CS2 ec 3.2.1.21 ASZ82_01558 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) ASZ82_01561 ENOG4107QZV Type I secretion membrane fusion protein ASZ82_01563 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ASZ82_01564 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ASZ82_01565 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) ASZ82_01566 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ASZ82_01567 ENOG4105C4M (Ubiquinol oxidase) subunit I ASZ82_01569 ENOG4105C9Q fumarate hydratase class II ASZ82_01575 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) ASZ82_01576 ENOG4105DUM transcriptional regulator, lysR family ASZ82_01577 ENOG4108TWJ NADH dehydrogenase subunit 5 ASZ82_01579 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ASZ82_01581 ENOG4105CH6 catalase ASZ82_01584 ENOG4107FQX Alpha-acetolactate decarboxylase ASZ82_01585 ENOG4105C7K acetolactate synthase ASZ82_01587 ENOG4105BZU Histidine kinase ASZ82_01588 ENOG4106TD9 Diguanylate cyclase ASZ82_01589 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) ASZ82_01590 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) ASZ82_01591 ENOG4105F0Z galactose-1-phosphate uridylyltransferase ASZ82_01596 ENOG4105BZU Histidine kinase ASZ82_01599 ENOG4107R88 Chemotaxis protein (CheV) ASZ82_01601 ENOG4106YYS transcriptional regulatory protein ASZ82_01602 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism ASZ82_01604 ENOG4107V40 secretion protein, HlyD family ASZ82_01608 ENOG4105CVG Homoserine O-transsuccinylase ASZ82_01609 ENOG41090FY type IV pilus biogenesis stability protein PilW ASZ82_01612 ENOG4108VKG metal-dependent hydrolase ASZ82_01614 ENOG4105F04 LysR family Transcriptional regulator ASZ82_01618 ENOG4105DFG type I secretion outer membrane protein ASZ82_01619 ENOG4105CDV Ompa motb domain protein ASZ82_01620 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) ASZ82_01621 ENOG4105E3Q saccharopine dehydrogenase ASZ82_01623 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) ASZ82_01626 ENOG4108I0Y (ABC) transporter ASZ82_01627 ENOG4105UQX Mate efflux family protein ASZ82_01628 ENOG4105CGD Nad-dependent epimerase dehydratase ASZ82_01630 ENOG4105C2C drug resistance transporter, Bcr CflA ASZ82_01631 ENOG4105I08 Pseudouridine synthase ASZ82_01632 ENOG4105CFI type iii restriction protein res subunit ASZ82_01636 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) ASZ82_01639 ENOG4108N3W hemolysin secretion protein ASZ82_01645 ENOG4105KXC Collagenase ASZ82_01647 ENOG4105BZU Histidine kinase ASZ82_01648 ENOG4105BZU Histidine kinase ASZ82_01649 ENOG4105CJW magnesium transporter ASZ82_01652 ENOG4105C44 Serine transporter ASZ82_01654 ENOG4105CJ1 ABC, transporter ASZ82_01655 ENOG4107QWP ABC-2 type transporter ASZ82_01657 ENOG4105XZD Fe-S protein ASZ82_01659 ENOG4105VNH ABC transporter solute-binding protein ASZ82_01660 ENOG4105CXZ ABC transporter, permease ASZ82_01661 ENOG4108VGW abc transporter atp-binding protein ASZ82_01662 ENOG4108T9J Cdp-alcohol phosphatidyltransferase ASZ82_01663 ENOG4108W1A pseudouridine synthase ASZ82_01665 ENOG4105C8J )-transporter ASZ82_01666 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) ASZ82_01667 ENOG4105C28 cystathionine ASZ82_01668 ENOG4108R3E Dna-3-methyladenine glycosylase i ASZ82_01671 ENOG4105C1P efflux transporter, rnd family, mfp subunit ASZ82_01674 ENOG41087YS Phage shock protein A ASZ82_01675 ENOG4105E51 psp operon transcriptional activator ASZ82_01676 ENOG4108J59 Extracellular solute-binding protein, family 5 ASZ82_01677 ENOG4108I5W peptide transport system, permease protein ASZ82_01678 ENOG4108EU3 peptide transport system, permease ASZ82_01679 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein ASZ82_01680 ENOG4108JQ2 peptide transport system atp-binding protein ASZ82_01683 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase ASZ82_01688 ENOG4107QY8 reductase ASZ82_01692 ENOG4105TMB Formate nitrite transporter ASZ82_01694 ENOG4108535 NAD dependent epimerase/dehydratase family ASZ82_01695 ENOG4105GFG DUF218 domain ASZ82_01697 ENOG4107835 probably involved in intracellular septation (By similarity) ASZ82_01698 ENOG4105NAU thioesterase Superfamily protein ASZ82_01699 ENOG4105K9H YciI-like protein ASZ82_01701 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) ASZ82_01702 ENOG4105DZ2 Transcriptional regulator ASZ82_01706 ENOG4105BZU Histidine kinase ASZ82_01707 ENOG4105CCT upf0313 protein ASZ82_01709 ENOG4105EW9 transcriptional regulator AsnC family ASZ82_01710 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) ASZ82_01711 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) ASZ82_01712 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) ASZ82_01713 ENOG4106371 Methyltransferase ASZ82_01714 ENOG4107S90 membrAne ASZ82_01715 ENOG4106WF9 DNA-binding transcriptional regulator TorR ASZ82_01716 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) ASZ82_01717 ENOG4105ETE Transcriptional regulator (LacI family ASZ82_01718 ENOG4105HP8 regulator of competence-specific genes ASZ82_01722 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) ASZ82_01723 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) ASZ82_01725 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) ASZ82_01726 ENOG4105RKX Protein of unknown function (DUF2498) ASZ82_01727 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase ASZ82_01728 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) ASZ82_01729 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate ASZ82_01730 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) ASZ82_01733 ENOG4107QPN acyl-Coa dehydrogenase ASZ82_01734 ENOG41067SE Tetr family transcriptional regulator ASZ82_01737 ENOG4105MTM Protein of unknown function (DUF1496) ASZ82_01738 ENOG4105C26 Dehydrogenase ASZ82_01739 ENOG4108R86 Transcriptional regulator ASZ82_01744 ENOG4105F1S paraquat-inducible protein a ASZ82_01745 ENOG4105DY2 Paraquat-inducible protein b ASZ82_01750 ENOG4105DFP Integrase ASZ82_01751 ENOG4105DFP Integrase ASZ82_01752 ENOG4105C0D helicase ASZ82_01756 ENOG4105DZR Type I site-specific deoxyribonuclease ASZ82_01760 ENOG4105CVR type I restriction-modification system ASZ82_01764 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) ASZ82_01765 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) ASZ82_01766 ENOG4105QEK Transcriptional regulator ASZ82_01768 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ASZ82_01769 ENOG41069H7 transport system small permease component ASZ82_01770 ENOG4108ERU trap dicarboxylate transporter subunit DctP ASZ82_01771 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) ASZ82_01772 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) ASZ82_01773 ENOG4105CE4 GlcNAc 6-P deacetylase ASZ82_01774 ENOG4108478 ec 3.2.1.18 ASZ82_01776 ENOG4108YGG dna repair protein ASZ82_01782 ENOG4108NYK Tape measure protein ASZ82_01804 ENOG4105CVP deoxyribo-dipyrimidine photolyase ASZ82_01806 ENOG4105VYA Uncharacterized conserved protein (DUF2132) ASZ82_01807 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family ASZ82_01808 ENOG4105C26 Dehydrogenase ASZ82_01810 ENOG4105DM4 PTS System ASZ82_01811 ENOG4105DM4 PTS System ASZ82_01812 ENOG4108YRF PTS System ASZ82_01814 ENOG4106R3P AraC family transcriptional regulator ASZ82_01815 ENOG4105DM4 PTS System ASZ82_01816 ENOG4105EIP mannose-6-phosphate isomerase ASZ82_01817 ENOG4108RNS Exports L-alanine (By similarity) ASZ82_01818 ENOG4105BZU Histidine kinase ASZ82_01820 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) ASZ82_01822 ENOG4105KCK Peptidoglycan-associated lipoprotein ASZ82_01823 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) ASZ82_01825 ENOG4105M8F Biopolymer transport protein exbD tolR ASZ82_01826 ENOG4105E02 MotA TolQ exbB proton channel ASZ82_01827 ENOG4107YD3 Thioesterase ASZ82_01828 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ASZ82_01829 ENOG4105C4M (Ubiquinol oxidase) subunit I ASZ82_01830 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) ASZ82_01831 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) ASZ82_01832 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) ASZ82_01833 ENOG4105C8N cysteinyl-tRNA synthetase ASZ82_01834 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) ASZ82_01835 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) ASZ82_01836 ENOG4105D58 Diguanylate phosphodiesterase ASZ82_01839 ENOG4105ZU8 porin-like protein H ASZ82_01840 ENOG4105DVT helicase ASZ82_01841 ENOG4105EJ9 Membrane ASZ82_01842 ENOG4108URS primosomal replication protein n'' ASZ82_01843 ENOG4106428 Protein of unknown function (DUF2496) ASZ82_01844 ENOG4105C8Q Methyl-accepting chemotaxis ASZ82_01845 ENOG4105CGK Exodeoxyribonuclease III ASZ82_01846 ENOG4106YG3 ABC transporter ASZ82_01847 ENOG4105DSP amino acid AbC transporter ASZ82_01848 ENOG4105E89 ABC transporter ASZ82_01849 ENOG4108JEH abc transporter atp-binding protein ASZ82_01851 ENOG4105C6N Formate acetyltransferase ASZ82_01853 ENOG4105C8Q Methyl-accepting chemotaxis ASZ82_01854 ENOG4105F1A Pyruvate formate-lyase ASZ82_01856 ENOG4105XWI UPF0304 protein ASZ82_01857 ENOG4105CYN Serine protein kinase ASZ82_01858 ENOG4106AKX UPF0229 protein ASZ82_01859 ENOG4105ED1 spovr family ASZ82_01860 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) ASZ82_01862 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) ASZ82_01863 ENOG4105BZ1 (ABC) transporter ASZ82_01864 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 ASZ82_01866 ENOG4105D60 lipoprotein releasing system transmembrane protein ASZ82_01867 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) ASZ82_01868 ENOG4105D60 lipoprotein releasing system transmembrane protein ASZ82_01870 ENOG4108JA2 transcriptioN-repair coupling factor ASZ82_01872 ENOG4106M3D hemolysin ASZ82_01874 ENOG4105CEP NADH dehydrogenase ASZ82_01881 ENOG4105K59 histidine triad (HIT) protein ASZ82_01882 ENOG4108NVR Methyl-accepting chemotaxis ASZ82_01884 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) ASZ82_01885 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) ASZ82_01886 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) ASZ82_01887 ENOG4105CNU cell division protein FtsK ASZ82_01888 ENOG4105EW9 transcriptional regulator AsnC family ASZ82_01889 ENOG4105DCF alanine dehydrogenase ASZ82_01891 ENOG4107R11 Transcriptional regulator ASZ82_01894 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase ASZ82_01895 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) ASZ82_01896 ENOG4105CFV Tetratricopeptide repeat protein ASZ82_01897 ENOG4105Q4A inner membrane protein yciS ASZ82_01898 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) ASZ82_01899 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) ASZ82_01900 ENOG4105CAT Cytidine monophosphate kinase ASZ82_01901 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein ASZ82_01902 ENOG4105EIN peptidylprolyl cis-trans isomerase ASZ82_01903 ENOG4105K70 DNA-binding protein ASZ82_01904 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) ASZ82_01905 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) ASZ82_01906 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) ASZ82_01907 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation ASZ82_01910 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASZ82_01911 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ASZ82_01912 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ ASZ82_01913 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit ASZ82_01914 ENOG4105CNG UPF0061 protein ASZ82_01917 ENOG4105BZU Histidine kinase ASZ82_01919 ENOG4108HPI phosphatidate Cytidylyltransferase ASZ82_01926 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) ASZ82_01929 ENOG4105JQN Transcriptional regulator ASZ82_01932 ENOG4107QY8 reductase ASZ82_01933 ENOG4105CUW cytochrome C-TYPE protein ASZ82_01934 ENOG410662T chitinase ASZ82_01935 ENOG4105D9N nucleoside ASZ82_01936 ENOG4105JQN Transcriptional regulator ASZ82_01937 ENOG4105CVE Lytic murein transglycosylase ASZ82_01938 ENOG4105VNG YcgL domain-containing protein ASZ82_01939 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) ASZ82_01940 ENOG4107QMS site-determining protein ASZ82_01941 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) ASZ82_01946 ENOG4107S74 Lysophospholipid transporter LplT ASZ82_01948 ENOG4108N3W hemolysin secretion protein ASZ82_01949 ENOG4108JCI Transcriptional regulator ASZ82_01950 ENOG4105DKK Benzoate ASZ82_01951 ENOG4105CEY Amp-dependent synthetase and ligase ASZ82_01952 ENOG4105DNI Converts SHCHC to OSB (By similarity) ASZ82_01953 ENOG4108IPT Naphthoate synthase ASZ82_01954 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) ASZ82_01955 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) ASZ82_01956 ENOG4105E4F Isochorismate synthase ASZ82_01957 ENOG4105CHM Aminotransferase ASZ82_01958 ENOG4105DK2 UPF0207 protein ASZ82_01959 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein ASZ82_01963 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) ASZ82_01964 ENOG4105CEY Amp-dependent synthetase and ligase ASZ82_01965 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) ASZ82_01968 ENOG41072GX Peptidase M22 Glycoprotease ASZ82_01969 ENOG4105DVT helicase ASZ82_01971 ENOG4105CIY formyltetrahydrofolate deformylase ASZ82_01972 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ASZ82_01973 ENOG4105D07 Signal peptide peptidase, SppA ASZ82_01974 ENOG4105HDK L-asparaginase ASZ82_01975 ENOG4105VUT cytoplasmic protein ASZ82_01978 ENOG4105E0X reductase ASZ82_01979 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase ASZ82_01980 ENOG4105DSB aldose 1-epimerase ASZ82_01982 ENOG4105DHI Methyltransferase ASZ82_01985 ENOG4107R88 Chemotaxis protein (CheV) ASZ82_01986 ENOG4105DAG ROK family ASZ82_01987 ENOG4105CA9 Pyruvate kinase ASZ82_01988 ENOG4108NRW Phospholipase, patatin family ASZ82_01991 ENOG4105C8J )-transporter ASZ82_01992 ENOG4105CI1 PTS System ASZ82_01993 ENOG4105F8V Hydrolase, tatD family ASZ82_01994 ENOG4107QRG dna polymerase iii ASZ82_01995 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) ASZ82_01996 ENOG4105HHA aminodeoxychorismate lyase ASZ82_01997 ENOG4105YAZ 4-amino-4-deoxychorismate lyase ASZ82_01998 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) ASZ82_01999 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) ASZ82_02000 ENOG4105CHR reductase ASZ82_02001 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase ASZ82_02002 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) ASZ82_02003 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) ASZ82_02004 ENOG4105VGS 50s ribosomal protein l32 ASZ82_02005 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein ASZ82_02006 ENOG4108UHJ MAF-like protein ASZ82_02007 ENOG4105EI2 Pseudouridine synthase ASZ82_02008 ENOG4105C03 ribonuclease ASZ82_02009 ENOG4105CHH sulfate transporter ASZ82_02011 ENOG4108EKI Dehydrogenase ASZ82_02012 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein ASZ82_02013 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) ASZ82_02014 ENOG4105DFD Na H antiporter ASZ82_02016 ENOG4106V8H Nucleoid-associated protein ASZ82_02018 ENOG4105E68 Sulfatase ASZ82_02021 ENOG4105DGU Histone deacetylase ASZ82_02022 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) ASZ82_02023 ENOG4105M2J Glutaredoxin ASZ82_02024 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ASZ82_02028 ENOG410903C (LipO)protein ASZ82_02030 ENOG4105KWW Biogenesis protein ASZ82_02031 ENOG4107QX9 Thiol disulfide interChange protein ASZ82_02032 ENOG4105DA4 cytochrome c-type biogenesis protein ASZ82_02033 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) ASZ82_02034 ENOG41067VX Heme exporter protein ASZ82_02035 ENOG41060IM Heme exporter protein ASZ82_02036 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) ASZ82_02037 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) ASZ82_02039 ENOG4108V3W Chemotaxis protein, CheW ASZ82_02041 ENOG4107QJE Chromosome Partitioning Protein ASZ82_02042 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) ASZ82_02043 ENOG4105CBS Chea signal transduction histidine kinase ASZ82_02044 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) ASZ82_02045 ENOG4108VYJ response regulator receiver protein ASZ82_02046 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ASZ82_02047 ENOG4107R21 site-determining protein ASZ82_02048 ENOG4105FZW flagellar biosynthesis regulator FlhF ASZ82_02049 ENOG4105D7B Flagellar biosynthesis protein flha ASZ82_02050 ENOG4108BY2 phosphohistidine phosphatase ASZ82_02052 ENOG4108JQM Insulinase (Peptidase family M16) ASZ82_02054 ENOG4105C75 arginyL-tRNA synthetase ASZ82_02058 ENOG4105XFK Ferrous iron transport protein A ASZ82_02059 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) ASZ82_02060 ENOG4105NXV High-affinity zinc uptake system protein ASZ82_02061 ENOG4105FDK ABC transporter ASZ82_02062 ENOG4105FAV ABC, transporter ASZ82_02063 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha ASZ82_02064 ENOG4105CMV Succinyl-CoA synthetase subunit beta ASZ82_02065 ENOG4105C7S Dehydrogenase ASZ82_02066 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 ASZ82_02067 ENOG4105E33 succinate dehydrogenase ASZ82_02068 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) ASZ82_02069 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein ASZ82_02070 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit ASZ82_02071 ENOG4105BZN citrate synthase ASZ82_02072 ENOG4107QNR UPF0135 protein ASZ82_02074 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 ASZ82_02075 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) ASZ82_02076 ENOG4105EV9 Alpha Beta Hydrolase ASZ82_02078 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) ASZ82_02079 ENOG41067MG lrgb family ASZ82_02080 ENOG4105VAW lrga family ASZ82_02081 ENOG4105CMU LysR family (Transcriptional regulator ASZ82_02083 ENOG41090R7 Ferric uptake ASZ82_02084 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) ASZ82_02085 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) ASZ82_02086 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) ASZ82_02087 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) ASZ82_02088 ENOG4105Q8W reductase ASZ82_02089 ENOG4105MH2 YfcL protein ASZ82_02090 ENOG4108BPE -transporting atpase ASZ82_02091 ENOG4105EN6 Membrane ASZ82_02092 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase ASZ82_02093 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) ASZ82_02095 ENOG4105D00 flagellar biosynthetic protein flhB ASZ82_02096 ENOG4105D19 Role in flagellar biosynthesis (By similarity) ASZ82_02097 ENOG4105VS8 Flagellar biosynthetic protein fliq ASZ82_02098 ENOG4105CN7 Flagellar biosynthetic protein FliP ASZ82_02099 ENOG4105VTB flagellar biosynthesis protein fliO ASZ82_02100 ENOG4105DD5 Flagellar motor switch protein ASZ82_02101 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) ASZ82_02102 ENOG4105X6C Flagellar basal body-associated protein FliL ASZ82_02106 ENOG4108JIR Flagellum-specific ATP synthase ASZ82_02107 ENOG4105W2B Flagellar assembly protein ASZ82_02108 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) ASZ82_02109 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) ASZ82_02110 ENOG4105VQ0 flagellar hook-basal body complex protein fliE ASZ82_02111 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASZ82_02112 ENOG4105BZU Histidine kinase ASZ82_02113 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASZ82_02114 ENOG4105MQ3 flagellar protein FliS ASZ82_02116 ENOG4107W9T flagellar hook-associated ASZ82_02117 ENOG41063QE flagellar protein FlaG ASZ82_02118 ENOG4105I03 Flagellin ASZ82_02119 ENOG4105I03 Flagellin ASZ82_02120 ENOG4105I03 Flagellin ASZ82_02121 ENOG4105EZR dyp-type peroxidase family protein ASZ82_02122 ENOG4105QZU Inner membrane protein YfeZ ASZ82_02125 ENOG4105KUZ arsenate reductase ASZ82_02126 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) ASZ82_02129 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) ASZ82_02130 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ASZ82_02132 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen ASZ82_02133 ENOG4105C8Q Methyl-accepting chemotaxis ASZ82_02136 ENOG4105ERG peptidase m48, ste24p ASZ82_02137 ENOG4105K89 arsenate reductase ASZ82_02138 ENOG4105CS1 NAD(P)H quinone oxidoreductase ASZ82_02141 ENOG4105C2W permease ASZ82_02142 ENOG4108Z66 YbaK ebsC protein ASZ82_02144 ENOG4105CGH 5'-nucleotidase ASZ82_02145 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase ASZ82_02146 ENOG41063JG Transcriptional regulator ASZ82_02147 ENOG4108YY7 Invasion gene expression up-regulator SirB ASZ82_02148 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) ASZ82_02149 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) ASZ82_02150 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) ASZ82_02151 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) ASZ82_02152 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) ASZ82_02153 ENOG4105C5T Phosphoribosyl pyrophosphate synthase ASZ82_02154 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) ASZ82_02155 ENOG4105C3G gtp-binding protein ASZ82_02173 ENOG4105I03 Flagellin ASZ82_02202 ENOG4105ED4 portal protein ASZ82_02219 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ASZ82_02221 ENOG4105I03 Flagellin ASZ82_02225 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj ASZ82_02226 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) ASZ82_02227 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) ASZ82_02228 ENOG4105CGA flagellar basal-body rod protein FlgG ASZ82_02229 ENOG4108KPB Flagellar basal-body rod protein FlgF ASZ82_02230 ENOG4105BZE flagellar hook protein, FlgE ASZ82_02231 ENOG4105W00 Flagellar hook capping protein ASZ82_02232 ENOG4108ZC9 flagellar basal-body rod protein flgc ASZ82_02233 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) ASZ82_02234 ENOG4105BZU Histidine kinase ASZ82_02235 ENOG4107R88 Chemotaxis protein (CheV) ASZ82_02242 ENOG4105C0W non-ribosomal peptide synthetase ASZ82_02243 ENOG4105Q26 Siderophore-interacting protein ASZ82_02244 ENOG4107RBR Receptor ASZ82_02246 ENOG4105UYK outer membrane protein a ASZ82_02247 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) ASZ82_02248 ENOG4105C59 p-type ATPase ASZ82_02250 ENOG4105E2D ec 3.2.1.52 ASZ82_02253 ENOG4105MBR gumn family ASZ82_02256 ENOG4108DG9 Smr protein MutS2 ASZ82_02257 ENOG4105FE9 pseudouridine synthase ASZ82_02258 ENOG4105BZU Histidine kinase ASZ82_02259 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) ASZ82_02260 ENOG4105CXB phosphoribosylaminoimidazole synthetase ASZ82_02261 ENOG4108V3E phosphoribosylglycinamide formyltransferase ASZ82_02262 ENOG4105E7A Glutamine amidotransferase ASZ82_02263 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) ASZ82_02264 ENOG4107QPN acyl-Coa dehydrogenase ASZ82_02266 ENOG4108JDX DNA polymerase iii, epsilon subunit ASZ82_02267 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) ASZ82_02268 ENOG4105D1A Methyltransferase ASZ82_02269 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) ASZ82_02270 ENOG4105E9H Lytic Murein transglycosylase ASZ82_02272 ENOG4108YZA Nitrogen regulatory protein pii ASZ82_02273 ENOG4105PY6 Phenolic acid decarboxylase ASZ82_02274 ENOG4105N7H Cytochrome ASZ82_02275 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) ASZ82_02276 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) ASZ82_02277 ENOG4105C0B DNA polymerase III (alpha subunit) ASZ82_02278 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) ASZ82_02279 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) ASZ82_02280 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) ASZ82_02281 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) ASZ82_02282 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) ASZ82_02283 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) ASZ82_02285 ENOG4105DZP Membrane-associated zinc metalloprotease ASZ82_02286 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) ASZ82_02287 ENOG4105KNE Phosphatidate cytidylyltransferase ASZ82_02288 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) ASZ82_02289 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) ASZ82_02290 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) ASZ82_02291 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) ASZ82_02292 ENOG4105CE9 30S ribosomal protein S2 ASZ82_02293 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) ASZ82_02294 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) ASZ82_02295 ENOG4108T8E UPF0325 protein ASZ82_02296 ENOG4108ZAI phosphatidylglycerophosphatase a ASZ82_02297 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) ASZ82_02298 ENOG4107YIM Involved in the transcription termination process (By similarity) ASZ82_02299 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) ASZ82_02302 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) ASZ82_02303 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) ASZ82_02304 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) ASZ82_02305 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) ASZ82_02306 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) ASZ82_02308 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) ASZ82_02309 ENOG4105C7N Xanthine uracil vitamin C permease ASZ82_02310 ENOG4105CIN aminoacyl-histidine dipeptidase ASZ82_02311 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) ASZ82_02312 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) ASZ82_02314 ENOG4105C8J )-transporter ASZ82_02315 ENOG4105BZU Histidine kinase ASZ82_02317 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) ASZ82_02319 ENOG4105CJ2 (LipO)protein ASZ82_02320 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) ASZ82_02321 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ASZ82_02322 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ASZ82_02323 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ASZ82_02324 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ASZ82_02325 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ASZ82_02326 ENOG4105M85 Bola protein ASZ82_02327 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) ASZ82_02329 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) ASZ82_02330 ENOG4105EYM Major Facilitator superfamily ASZ82_02332 ENOG4105K6V RNA polymerase ASZ82_02334 ENOG4105DRB nucleoside-specific channel-forming protein ASZ82_02335 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) ASZ82_02336 ENOG4107S0N DJ-1 family ASZ82_02337 ENOG4105C9B Cysteine desulfurase ASZ82_02338 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) ASZ82_02339 ENOG4105CUZ uba thif-type nad fad binding protein ASZ82_02340 ENOG4105CA3 membrane-bound lytic murein transglycosylase ASZ82_02342 ENOG4107QZM n-acetylglutamate synthase ASZ82_02344 ENOG4107QYX exodeoxyribonuclease v alpha ASZ82_02345 ENOG4107QKA exodeoxyribonuclease V beta ASZ82_02346 ENOG4105DSY exodeoxyribonuclease V, gamma ASZ82_02349 ENOG4105X2V dna damage-inducible protein ASZ82_02350 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) ASZ82_02352 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) ASZ82_02353 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) ASZ82_02356 ENOG4108Y51 tRNA-binding protein ASZ82_02357 ENOG41060NJ transcriptional regulator ASZ82_02358 ENOG4105CNT hydrolase family 2 ASZ82_02360 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase ASZ82_02361 ENOG4108IQE Amp-dependent synthetase and ligase ASZ82_02362 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) ASZ82_02363 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) ASZ82_02365 ENOG4105EAC phosphoserine phosphatase ASZ82_02367 ENOG4105D3A purine nucleoside phosphorylase DeoD-type ASZ82_02368 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) ASZ82_02369 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) ASZ82_02370 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) ASZ82_02372 ENOG4105D9N nucleoside ASZ82_02373 ENOG4105EYA deoxyribonuclease ASZ82_02376 ENOG4105BZG amino acid carrier protein ASZ82_02379 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) ASZ82_02380 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) ASZ82_02381 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) ASZ82_02382 ENOG4105D98 threonine synthase ASZ82_02383 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) ASZ82_02386 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) ASZ82_02388 ENOG41065U4 response regulator ASZ82_02389 ENOG4105BZU Histidine kinase ASZ82_02391 ENOG4105N5T Radical SAM Protein ASZ82_02395 ENOG4105CBC glutamate synthase ASZ82_02396 ENOG4105BZ8 glutamate synthase ASZ82_02398 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) ASZ82_02400 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) ASZ82_02401 ENOG4105EN6 Membrane ASZ82_02402 ENOG4105EJ9 Membrane ASZ82_02403 ENOG4107RRE RNA-directed DNA polymerase ASZ82_02407 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain ASZ82_02408 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain ASZ82_02410 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) ASZ82_02411 ENOG4105M6F mutator MutT protein ASZ82_02412 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving ASZ82_02414 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) ASZ82_02415 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) ASZ82_02416 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) ASZ82_02417 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) ASZ82_02418 ENOG4105DFU Cell wall formation (By similarity) ASZ82_02419 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) ASZ82_02421 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) ASZ82_02422 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) ASZ82_02423 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) ASZ82_02424 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) ASZ82_02425 ENOG4105CJN penicillin-binding protein ASZ82_02426 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) ASZ82_02427 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) ASZ82_02428 ENOG4107QN2 dihydrolipoyl dehydrogenase ASZ82_02429 ENOG4107QSN dihydrolipoamide acetyltransferase ASZ82_02430 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) ASZ82_02431 ENOG41073TP transcriptional regulator ASZ82_02432 ENOG4105CGH 5'-nucleotidase ASZ82_02433 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) ASZ82_02434 ENOG4105T95 Thiol disulfide interChange protein ASZ82_02435 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ASZ82_02436 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) ASZ82_02438 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase ASZ82_02440 ENOG4107QHF type ii secretion system protein e ASZ82_02441 ENOG4105D7Q type ii secretion system ASZ82_02442 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) ASZ82_02443 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) ASZ82_02444 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) ASZ82_02445 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) ASZ82_02446 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ASZ82_02447 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ASZ82_02448 ENOG4105IPS esterase ASZ82_02449 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) ASZ82_02450 ENOG4108SX3 cytoplasmic protein ASZ82_02451 ENOG41087AY ADP-Ribose pyrophosphatase ASZ82_02452 ENOG4105DFG type I secretion outer membrane protein ASZ82_02454 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) ASZ82_02455 ENOG4105C8Q Methyl-accepting chemotaxis ASZ82_02456 ENOG4105I7R Adenylate cyclase ASZ82_02457 ENOG4107IX6 phosphate transport regulator ASZ82_02458 ENOG4105CJ3 phosphate transporter ASZ82_02459 ENOG4106MWK domain protein ASZ82_02462 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate ASZ82_02463 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) ASZ82_02464 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) ASZ82_02466 ENOG4105DXN mazG family ASZ82_02467 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) ASZ82_02468 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) ASZ82_02469 ENOG4105BZU Histidine kinase ASZ82_02470 ENOG4108K0B C-di-gmp phosphodiesterase ASZ82_02473 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) ASZ82_02474 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) ASZ82_02475 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) ASZ82_02476 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) ASZ82_02477 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) ASZ82_02478 ENOG4105C3F Signal peptidase i ASZ82_02479 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) ASZ82_02480 ENOG4105WMJ Positive regulator of sigma E, RseC MucC ASZ82_02481 ENOG4105VQK sigma E regulatory protein, MucB RseB ASZ82_02483 ENOG4105EMN RNA polymerase sigma factor ASZ82_02484 ENOG4108IYU L-aspartate oxidase ASZ82_02486 ENOG4105Y75 tpr repeat protein ASZ82_02487 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) ASZ82_02489 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family ASZ82_02490 ENOG4105D0A hydroxylase ASZ82_02492 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) ASZ82_02493 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase ASZ82_02494 ENOG4105E66 phosphoriboisomerase A ASZ82_02495 ENOG4108JQ1 Dehydrogenase ASZ82_02496 ENOG4108ZP8 Acetolactate synthase small subunit ASZ82_02497 ENOG4105C7K acetolactate synthase ASZ82_02498 ENOG4108IQE Amp-dependent synthetase and ligase ASZ82_02499 ENOG41064T2 transcriptional regulator, lysR family ASZ82_02503 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) ASZ82_02504 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) ASZ82_02505 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) ASZ82_02506 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) ASZ82_02515 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase ASZ82_02518 ENOG4108K5H permease YjgP YjgQ family protein ASZ82_02519 ENOG4108M8S permease YjgP YjgQ family protein ASZ82_02520 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) ASZ82_02521 ENOG4105MYG DNA polymerase iii, chi subunit ASZ82_02522 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) ASZ82_02523 ENOG4105C5I Dehydrogenase ASZ82_02524 ENOG4105D3G Pseudouridine synthase ASZ82_02525 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) ASZ82_02527 ENOG4108IAB Phoh family ASZ82_02528 ENOG4105DBV ornithine carbamoyltransferase ASZ82_02529 ENOG4105CXT aspartate transcarbamylase ASZ82_02530 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) ASZ82_02531 ENOG4105KME endoribonuclease L-psp ASZ82_02532 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase ASZ82_02533 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) ASZ82_02534 ENOG4105VFK BolA family ASZ82_02536 ENOG4105E3I toluene tolerance ASZ82_02537 ENOG4107PE3 Mammalian cell entry related domain protein ASZ82_02538 ENOG4105CY3 ABC transporter, permease ASZ82_02539 ENOG4105DHJ ABC, transporter ASZ82_02541 ENOG4105C2X Arabinose 5-phosphate isomerase ASZ82_02542 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase ASZ82_02544 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA ASZ82_02545 ENOG4108IUZ ABC transporter ASZ82_02546 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ASZ82_02547 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA ASZ82_02548 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN ASZ82_02549 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) ASZ82_02550 ENOG41080Z8 PHOSPHOCARRIER protein ASZ82_02551 ENOG4105CJW magnesium transporter ASZ82_02552 ENOG4105CMS peptidase U62, modulator of DNA gyrase ASZ82_02553 ENOG4105N42 UPF0307 protein ASZ82_02554 ENOG4107T0D ABC, transporter ASZ82_02555 ENOG4106SMU thiamine transporter membrane protein ASZ82_02556 ENOG4105DP9 ABC transporter ASZ82_02557 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase ASZ82_02558 ENOG4105DFU Cell wall formation (By similarity) ASZ82_02559 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 ASZ82_02560 ENOG4105F0N pyrophosphate phospho-hydrolase ASZ82_02561 ENOG41066HZ AIG2-like family ASZ82_02563 ENOG4105CFU surface antigen ASZ82_02564 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) ASZ82_02565 ENOG4108UUE Transcriptional regulator ASZ82_02568 ENOG4105C19 ABC transporter ASZ82_02572 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) ASZ82_02573 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) ASZ82_02574 ENOG4105C11 sulfate adenylyltransferase), subunit 2 ASZ82_02575 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) ASZ82_02576 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic ASZ82_02578 ENOG4105C1J atp-dependent rna helicase ASZ82_02579 ENOG4107YB6 acetyltransferase, (GNAT) family ASZ82_02580 ENOG4108SXK Transporter Drug Metabolite Exporter family ASZ82_02582 ENOG4108V1T peptidylprolyl cis-trans isomerase ASZ82_02584 ENOG4108ZT0 50S ribosomal protein l17 ASZ82_02585 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ASZ82_02586 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) ASZ82_02587 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) ASZ82_02588 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits ASZ82_02590 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) ASZ82_02591 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) ASZ82_02592 ENOG4105VPB 50S ribosomal protein L30 ASZ82_02593 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) ASZ82_02594 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) ASZ82_02595 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) ASZ82_02596 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) ASZ82_02597 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) ASZ82_02598 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits ASZ82_02599 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) ASZ82_02600 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) ASZ82_02601 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal ASZ82_02602 ENOG41083MP 50s ribosomal protein l29 ASZ82_02603 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) ASZ82_02604 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) ASZ82_02605 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) ASZ82_02606 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) ASZ82_02607 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity ASZ82_02608 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) ASZ82_02609 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) ASZ82_02610 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) ASZ82_02611 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) ASZ82_02612 ENOG4105C2N RNA methyltransferase TrmH family group 3 ASZ82_02613 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) ASZ82_02614 ENOG4105E68 Sulfatase ASZ82_02615 ENOG4108UV7 flagellar protein motX ASZ82_02617 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis ASZ82_02618 ENOG4105D44 asparaginase ASZ82_02619 ENOG4108YZY peptidylprolyl cis-trans isomerase ASZ82_02622 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein ASZ82_02623 ENOG4105C5H ABC transporter ASZ82_02625 ENOG4105DNZ Alpha Beta Hydrolase ASZ82_02627 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) ASZ82_02628 ENOG4107RYR Transcriptional regulator, Crp Fnr family ASZ82_02630 ENOG4105C26 Dehydrogenase ASZ82_02632 ENOG4105C8Y Acetylornithine aminotransferase ASZ82_02633 ENOG4105DDQ anthranilate synthase ASZ82_02634 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) ASZ82_02637 ENOG4105C31 Tryptophanyl-tRNA synthetase ASZ82_02638 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) ASZ82_02639 ENOG4105DJV ribulose-phosphate 3-epimerase ASZ82_02640 ENOG4105DFE Dna adenine methylase ASZ82_02642 ENOG4105D49 3-dehydroquinate synthase ASZ82_02643 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) ASZ82_02644 ENOG4105E4G Type IV pilus ASZ82_02649 ENOG4108JQC penicillin-binding protein 1A ASZ82_02651 ENOG4105EHV domain protein ASZ82_02652 ENOG4107QN2 dihydrolipoyl dehydrogenase ASZ82_02654 ENOG4105CH7 arginosuccinase ASZ82_02655 ENOG4105CDH Citrulline--aspartate ligase ASZ82_02656 ENOG4105CAS nag kinase ASZ82_02657 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase ASZ82_02658 ENOG4105CWC Acetylornithine deacetylase ASZ82_02659 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) ASZ82_02662 ENOG4105D7W serine acetyltransferase ASZ82_02663 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase ASZ82_02664 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) ASZ82_02665 ENOG4107YZP Rhodanese domain protein ASZ82_02666 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) ASZ82_02668 ENOG4105E33 succinate dehydrogenase ASZ82_02669 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) ASZ82_02670 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) ASZ82_02671 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) ASZ82_02672 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein ASZ82_02674 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) ASZ82_02675 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) ASZ82_02680 ENOG4105CP7 Triose-phosphate isomerase ASZ82_02682 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) ASZ82_02683 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase ASZ82_02684 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) ASZ82_02685 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) ASZ82_02686 ENOG41063M6 Cell Division Protein ASZ82_02688 ENOG4105ETE Transcriptional regulator (LacI family ASZ82_02689 ENOG4105C25 Primosomal protein n' ASZ82_02690 ENOG4105VFB Binds the 23S rRNA (By similarity) ASZ82_02692 ENOG4105C6K Malic enzyme ASZ82_02693 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) ASZ82_02694 ENOG4105C28 cystathionine ASZ82_02695 ENOG4105CFH Aspartokinase ASZ82_02696 ENOG4105SYT Methylenetetrahydrofolate reductase ASZ82_02697 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) ASZ82_02698 ENOG4105CBT Fructose-1,6-bisphosphatase ASZ82_02699 ENOG4105CTQ phosphohexokinase ASZ82_02700 ENOG41076HS cation diffusion facilitator family transporter ASZ82_02702 ENOG4105E3W Two component transcriptional regulator (Winged helix family ASZ82_02703 ENOG4105E0F Histidine kinase ASZ82_02705 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) ASZ82_02706 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 ASZ82_02707 ENOG4105BZU Histidine kinase ASZ82_02708 ENOG4108IJ0 Aspartate ammonia-lyase ASZ82_02709 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter ASZ82_02713 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) ASZ82_02715 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) ASZ82_02717 ENOG4107QN1 sodium solute ASZ82_02718 ENOG4105EX9 Membrane ASZ82_02719 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) ASZ82_02720 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) ASZ82_02721 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) ASZ82_02722 ENOG4105CB5 ATP-dependent DNA helicase recG ASZ82_02723 ENOG4105C2W permease ASZ82_02724 ENOG4105E0F Histidine kinase ASZ82_02725 ENOG4105DPZ Two component transcriptional regulator (Winged helix family ASZ82_02726 ENOG4108RRZ Transcription elongation factor GreB ASZ82_02727 ENOG4105BZM domain protein ASZ82_02729 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) ASZ82_02731 ENOG4105MJ2 Competence protein ASZ82_02732 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) ASZ82_02733 ENOG4107RK2 ADP-ribose diphosphatase NudE ASZ82_02734 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase ASZ82_02735 ENOG4105PIC general secretion pathway protein N ASZ82_02736 ENOG4105U1E general secretion pathway protein M ASZ82_02737 ENOG4108BY5 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) ASZ82_02738 ENOG4108RTD type II secretion system protein K ASZ82_02739 ENOG4108WWZ General secretion pathway protein J ASZ82_02740 ENOG4105X5Z General secretion pathway protein I ASZ82_02741 ENOG4105VWV general secretion pathway protein h ASZ82_02742 ENOG4108VAU general secretion pathway protein G ASZ82_02743 ENOG4105D7Q type ii secretion system ASZ82_02744 ENOG4107QHF type ii secretion system protein e ASZ82_02746 ENOG4108XKW General secretion pathway protein C ASZ82_02747 ENOG4105VEJ Heat shock protein ASZ82_02748 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) ASZ82_02749 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase ASZ82_02751 ENOG4105SUU thioesterase domain ASZ82_02752 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) ASZ82_02757 ENOG4105C5F glutamine synthetase ASZ82_02759 ENOG4105CUX Signal transduction histidine kinase ASZ82_02760 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASZ82_02761 ENOG4105BZU Histidine kinase ASZ82_02762 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) ASZ82_02771 ENOG4108RR8 protoporphyrinogen oxidase ASZ82_02772 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) ASZ82_02773 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein ASZ82_02774 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ASZ82_02775 ENOG4105CHU acetyl-coa acetyltransferase ASZ82_02776 ENOG4105F52 Transcriptional regulator ASZ82_02777 ENOG4105CZQ inner membrane transport protein YdhC ASZ82_02778 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) ASZ82_02779 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) ASZ82_02780 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) ASZ82_02781 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) ASZ82_02782 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) ASZ82_02783 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) ASZ82_02784 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) ASZ82_02785 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) ASZ82_02786 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) ASZ82_02787 ENOG410684E atp synthase ASZ82_02788 ENOG4105FA0 parb-like partition protein ASZ82_02789 ENOG4107QJE Chromosome Partitioning Protein ASZ82_02790 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) ASZ82_02791 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) ASZ82_02806 ENOG4105CDY transcriptional regulatory protein ASZ82_02807 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase ASZ82_02808 ENOG4105C8Q Methyl-accepting chemotaxis ASZ82_02809 ENOG4108YYI Protein of unknown function (DUF2810) ASZ82_02810 ENOG41061ZR Transcriptional regulator ASZ82_02811 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) ASZ82_02812 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) ASZ82_02813 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) ASZ82_02814 ENOG4108WC9 type VI secretion system effector, hcp1 family ASZ82_02815 ENOG4105CS6 Rhs element vgr protein ASZ82_02820 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ASZ82_02822 ENOG4105C8P )-transporter ASZ82_02823 ENOG4108Q67 UPF0319 protein ASZ82_02827 ENOG4105C8Q Methyl-accepting chemotaxis ASZ82_02831 ENOG4105EYK Phosphatidylglycerophosphatase B ASZ82_02832 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) ASZ82_02838 ENOG4105D6U Sodium Glutamate Symporter ASZ82_02839 ENOG4105YE1 PilZ domain ASZ82_02842 ENOG4105EFX secretion protein, HlyD family ASZ82_02843 ENOG4105KK7 inner membrane protein YiaW ASZ82_02844 ENOG4106TD9 Diguanylate cyclase ASZ82_02847 ENOG4105D3A purine nucleoside phosphorylase DeoD-type ASZ82_02849 ENOG4107SEY Conserved Protein ASZ82_02851 ENOG4105CVP deoxyribo-dipyrimidine photolyase ASZ82_02852 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein ASZ82_02855 ENOG4105C1J atp-dependent rna helicase ASZ82_02856 ENOG4105CUG Oligopeptidase b ASZ82_02862 ENOG4105CVA phosphate ASZ82_02863 ENOG4105C8U phosphate abc transporter ASZ82_02864 ENOG4105E2Z phosphate ABC transporter (Permease ASZ82_02865 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) ASZ82_02866 ENOG4105BZU Histidine kinase ASZ82_02868 ENOG4105DWD nucleoside recognition domain protein ASZ82_02869 ENOG4105CHH sulfate transporter ASZ82_02871 ENOG4105DR5 peptidase ASZ82_02872 ENOG4105BZU Histidine kinase ASZ82_02873 ENOG4105EQ2 LysR family Transcriptional regulator ASZ82_02874 ENOG4105E5M Multidrug resistance protein D ASZ82_02875 ENOG4108Z4X TRANSCRIPTIONal ASZ82_02879 ENOG4105CK2 sodium dicarboxylate symporter ASZ82_02889 ENOG4107RH7 Nicotinate phosphoribosyltransferase ASZ82_02890 ENOG4105D9R oxidoreductase ASZ82_02892 ENOG4105BZU Histidine kinase ASZ82_02893 ENOG4107VXZ Hydrolase ASZ82_02895 ENOG4105D3G Pseudouridine synthase ASZ82_02906 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ASZ82_02907 ENOG4108JUB Transcriptional regulator ASZ82_02912 ENOG4105CS6 Rhs element vgr protein ASZ82_02916 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) ASZ82_02917 ENOG4105C2J ABC transporter ASZ82_02918 ENOG4105CNN ABC, transporter ASZ82_02919 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator ASZ82_02920 ENOG4108RVA ribokinase ASZ82_02921 ENOG4105ETE Transcriptional regulator (LacI family ASZ82_02922 ENOG4106Z1T Nicotinamide Mononucleotide Transporter ASZ82_02923 ENOG4106Z1T Nicotinamide Mononucleotide Transporter ASZ82_02924 ENOG4108I5U Uridine phosphorylase ASZ82_02926 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase ASZ82_02927 ENOG4105CXY transporter ASZ82_02930 ENOG4105CQZ Histidine kinase ASZ82_02931 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASZ82_02935 ENOG4105D5U fad dependent oxidoreductase ASZ82_02937 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) ASZ82_02939 ENOG4105KJM monovalent cation h antiporter subunit g ASZ82_02940 ENOG41080TA Multiple resistance and ph regulation protein f ASZ82_02941 ENOG4105SC1 monovalent cation H antiporter subunit E ASZ82_02942 ENOG4108JPZ Monovalent cation H antiporter subunit D ASZ82_02943 ENOG4105MKQ Monovalent cation H antiporter subunit C ASZ82_02944 ENOG4105D65 subunit l ASZ82_02946 ENOG4105Q9Y Universal stress protein ASZ82_02947 ENOG4105CIC tryptophan-specific transport protein ASZ82_02948 ENOG4105C0F tryptophanase EC 4.1.99.1 ASZ82_02951 ENOG4105VRT cytoplasmic protein ASZ82_02953 ENOG4105BZU Histidine kinase ASZ82_02954 ENOG4105VEQ Cold shock protein ASZ82_02962 ENOG4105C7R Atpase associated with various cellular activities aaa_3 ASZ82_02964 ENOG41069D7 Methyl-accepting chemotaxis ASZ82_02968 ENOG4105D9N nucleoside ASZ82_02970 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) ASZ82_02972 ENOG4108JUA Transcriptional regulator ASZ82_02973 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) ASZ82_02974 ENOG4105VEQ Cold shock protein ASZ82_02979 ENOG4108UNF response regulator ASZ82_02981 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) ASZ82_02982 ENOG4105C5I Dehydrogenase ASZ82_02986 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) ASZ82_02991 ENOG4108RS6 transposase ASZ82_02992 ENOG4105C1J atp-dependent rna helicase ASZ82_02993 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter ASZ82_02995 ENOG4107RA1 nh(3)-dependent nad( ) synthetase ASZ82_02996 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) ASZ82_02997 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase ASZ82_02998 ENOG4105BZU Histidine kinase ASZ82_03000 ENOG4107S6Z Na H antiporter ASZ82_03001 ENOG4105E5M Multidrug resistance protein D ASZ82_03004 ENOG4105BZU Histidine kinase ASZ82_03005 ENOG4105KUU lipolytic protein G-D-S-L family ASZ82_03007 ENOG4106M3D hemolysin ASZ82_03008 ENOG4108N3W hemolysin secretion protein ASZ82_03009 ENOG4107IFA Lipase (EC 3.1.1.3) ASZ82_03011 ENOG4107G87 m6 family metalloprotease domain protein ASZ82_03016 ENOG4105DHS permease protein ASZ82_03017 ENOG4105CM4 permease protein ASZ82_03018 ENOG4108IPW abc transporter atp-binding protein ASZ82_03022 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) ASZ82_03026 ENOG4105ETX regulatoR ASZ82_03028 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase ASZ82_03030 ENOG410667J hydrolase ASZ82_03036 ENOG4105DS1 cytochrome b561 ASZ82_03043 ENOG4105XJC Two component transcriptional regulator (Winged helix family ASZ82_03044 ENOG4105BZU Histidine kinase ASZ82_03051 ENOG4107QVI Methyltransferase, type 11 ASZ82_03054 ENOG4105C2C drug resistance transporter, Bcr CflA ASZ82_03055 ENOG4105C8Q Methyl-accepting chemotaxis ASZ82_03057 ENOG4105DZ1 carboxypeptidase ASZ82_03063 ENOG4108RS6 transposase ASZ82_03064 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor ASZ82_03066 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) ASZ82_03067 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) ASZ82_03070 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) ASZ82_03072 ENOG4105F2I Transposase ASZ82_03077 ENOG4105C22 threonyL-tRNA synthetase ASZ82_03078 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) ASZ82_03079 ENOG41082NX 50s ribosomal protein l35 ASZ82_03080 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) ASZ82_03086 ENOG4105YGK Pfam:UPF0157 ASZ82_03089 ENOG4105CYX Short-chain dehydrogenase reductase Sdr ASZ82_03093 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase ASZ82_03102 ENOG4105YGK Pfam:UPF0157 ASZ82_03131 ENOG4105EST Metal Dependent Phosphohydrolase ASZ82_03151 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A ASZ82_03155 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase ASZ82_03161 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase ASZ82_03162 ENOG4108S58 Phenazine biosynthesis protein PhzF ASZ82_03165 ENOG4105QNF Outer membrane lipoprotein ASZ82_03169 ENOG4105YGK Pfam:UPF0157 ASZ82_03170 ENOG4105N14 lysine exporter protein LysE YggA ASZ82_03175 ENOG4105YGK Pfam:UPF0157 ASZ82_03196 ENOG4105YGK Pfam:UPF0157 ASZ82_03199 ENOG41080ET plasmid maintenance system killer protein ASZ82_03200 ENOG4105VDM plasmid maintenance system antidote protein, xre family ASZ82_03202 ENOG4108S58 Phenazine biosynthesis protein PhzF ASZ82_03209 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase ASZ82_03215 ENOG4105QNF Outer membrane lipoprotein ASZ82_03226 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein ASZ82_03235 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase ASZ82_03239 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system ASZ82_03240 ENOG4105W08 virulence gene repressor rsal ASZ82_03243 ENOG4105F2I Transposase ASZ82_03244 ENOG4105EQK -acetyltransferase ASZ82_03247 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase ASZ82_03264 ENOG4108RS6 transposase ASZ82_03275 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase ASZ82_03280 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase ASZ82_03281 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) ASZ82_03282 ENOG4105CGF Aromatic amino acid aminotransferase ASZ82_03283 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) ASZ82_03285 ENOG4105DM4 PTS System ASZ82_03286 ENOG4105DE4 1-phosphofructokinase ASZ82_03287 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein ASZ82_03288 ENOG4107B7Y DNA-binding transcriptional regulator FruR ASZ82_03289 ENOG4107RFY SbcCD D subunit ASZ82_03290 ENOG4105EYH Exonuclease ASZ82_03291 ENOG4108MGY Histidine kinase ASZ82_03292 ENOG4107KBT 8-Amino-7-oxononanoate synthase ASZ82_03294 ENOG4105CMQ Chloride channel ASZ82_03295 ENOG4105CKI cobalamin synthesis protein ASZ82_03296 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) ASZ82_03297 ENOG4105DFH Transport of potassium into the cell (By similarity) ASZ82_03298 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) ASZ82_03299 ENOG4105C08 Histidine kinase ASZ82_03300 ENOG4105EEX Two component transcriptional regulator (Winged helix family ASZ82_03301 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) ASZ82_03302 ENOG4108RHM integral membrane protein ASZ82_03304 ENOG4105EPM Diguanylate phosphodiesterase ASZ82_03306 ENOG4105DS1 cytochrome b561 ASZ82_03308 ENOG4105TMB Formate nitrite transporter ASZ82_03309 ENOG4105DUM transcriptional regulator, lysR family ASZ82_03310 ENOG4108UQ5 membrane protein YcdZ ASZ82_03311 ENOG4105CPB ATP-dependent endonuclease of the OLD family ASZ82_03312 ENOG4105CGH 5'-nucleotidase ASZ82_03313 ENOG4105DU1 integral membrane protein, terc ASZ82_03316 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA ASZ82_03324 ENOG4105BZU Histidine kinase ASZ82_03326 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) ASZ82_03328 ENOG4105BZU Histidine kinase ASZ82_03331 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) ASZ82_03332 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) ASZ82_03334 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ASZ82_03338 ENOG4108ZJT translation initiation factor, Sui1 ASZ82_03340 ENOG4105CPF Cell wall formation (By similarity) ASZ82_03342 ENOG4105CD5 CoA-binding domain protein ASZ82_03343 ENOG4105CWB LysR family transcriptional Regulator ASZ82_03348 ENOG4105KA0 thioesterase Superfamily protein ASZ82_03353 ENOG4105CYM Glutathione S-transferase ASZ82_03356 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) ASZ82_03357 ENOG4108JQ5 ABC transporter ASZ82_03358 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component ASZ82_03359 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component ASZ82_03360 ENOG4105E43 Extracellular solute-binding protein, family 5 ASZ82_03365 ENOG4105DUX Transporter ASZ82_03368 ENOG4107RCV ABC transporter, permease ASZ82_03371 ENOG4107STF Involved in phosphonate degradation (By similarity) ASZ82_03372 ENOG4108JPW Aminotransferase ASZ82_03373 ENOG4108KAZ Involved in phosphonate degradation (By similarity) ASZ82_03374 ENOG4105NXH GreA GreB family elongation factor ASZ82_03375 ENOG4105PAD Hydrolase ASZ82_03377 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain ASZ82_03380 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) ASZ82_03382 ENOG4105CKU formyltetrahydrofolate synthetase ASZ82_03383 ENOG4105E0X reductase ASZ82_03384 ENOG4105EUJ GTP cyclohydrolase i ASZ82_03385 ENOG4105CVM Molybdenum cofactor synthesis domain protein ASZ82_03386 ENOG4105D06 uba thif-type nad fad binding protein ASZ82_03388 ENOG4105KHC sulfurtransferase ASZ82_03389 ENOG4107RHR regulatoR ASZ82_03390 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) ASZ82_03391 ENOG4105CV1 Transketolase (EC 2.2.1.1) ASZ82_03397 ENOG4108M3J Dehydrogenase ASZ82_03400 ENOG4105RA2 Membrane ASZ82_03403 ENOG4105ETT transcriptional Regulator, LysR family ASZ82_03404 ENOG41067V3 Antibiotic biosynthesis monooxygenase ASZ82_03405 ENOG4108RCM Nitroreductase ASZ82_03410 ENOG41080HT Transcriptional regulator, arsr family ASZ82_03412 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase ASZ82_03421 ENOG4105C5Y PTS System ASZ82_03422 ENOG4105ETE Transcriptional regulator (LacI family ASZ82_03423 ENOG4107R3K hydrolase ASZ82_03424 ENOG4105D7K pfkb domain protein ASZ82_03425 ENOG4105C6V Glycerol-3-phosphate dehydrogenase ASZ82_03426 ENOG4108NVR Methyl-accepting chemotaxis ASZ82_03427 ENOG4108ZG0 Ompa motb domain protein ASZ82_03428 ENOG4108V1T peptidylprolyl cis-trans isomerase ASZ82_03429 ENOG4107VXZ Hydrolase ASZ82_03430 ENOG4108N3W hemolysin secretion protein ASZ82_03431 ENOG4105CEE C4-dicarboxylate transporter ASZ82_03432 ENOG4105EJQ L-serine dehydratase ASZ82_03437 ENOG4105ETE Transcriptional regulator (LacI family ASZ82_03438 ENOG4105WH1 Two component transcriptional regulator luxr family ASZ82_03439 ENOG4105BZU Histidine kinase ASZ82_03442 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ASZ82_03446 ENOG4105DHT Metal Dependent Phosphohydrolase ASZ82_03447 ENOG4108KX4 response regulator ASZ82_03448 ENOG4105BZU Histidine kinase ASZ82_03449 ENOG4105CXY transporter ASZ82_03450 ENOG4105C4Y ABC transporter ASZ82_03451 ENOG4107RCV ABC transporter, permease ASZ82_03452 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ASZ82_03453 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class ASZ82_03455 ENOG4105CHU acetyl-coa acetyltransferase ASZ82_03457 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ASZ82_03458 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ASZ82_03461 ENOG4105BZU Histidine kinase ASZ82_03462 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) ASZ82_03465 ENOG4108I6A alcohol dehydrogenase ASZ82_03467 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta ASZ82_03469 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC ASZ82_03471 ENOG4105CXY transporter ASZ82_03472 ENOG4105CA9 Pyruvate kinase ASZ82_03473 ENOG4105BZU Histidine kinase ASZ82_03474 ENOG4108SV3 Tmao reductase system periplasmic protein tort ASZ82_03475 ENOG4108Z5K methylglyoxal synthase ASZ82_03476 ENOG4108RWI nicotinamidase ASZ82_03478 ENOG41080IJ Diacylglycerol kinase ASZ82_03481 ENOG41088T4 Helicase IV ASZ82_03482 ENOG4105EM2 membrane ASZ82_03488 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) ASZ82_03489 ENOG4105E0C molybdate abc transporter ASZ82_03490 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein ASZ82_03491 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) ASZ82_03500 ENOG4105BZU Histidine kinase ASZ82_03501 ENOG4108QGH periplasmic ASZ82_03503 ENOG41082IR Excinuclease ABC C subunit domain protein ASZ82_03510 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) ASZ82_03511 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) ASZ82_03513 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A ASZ82_03514 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B ASZ82_03515 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) ASZ82_03516 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) ASZ82_03517 ENOG4105K63 Thioredoxin ASZ82_03524 ENOG4105DUM transcriptional regulator, lysR family ASZ82_03525 ENOG4105DMR ABC, transporter ASZ82_03526 ENOG4105GBT ABC transporter ASZ82_03527 ENOG4106PMH Extracellular solute-binding protein family 3 ASZ82_03528 ENOG4105E5Z arginine transporter ATP-binding subunit ASZ82_03530 ENOG4105EV2 VWA domain protein interacting with AAA ATPase ASZ82_03532 ENOG4108YZ4 nudix hydrolase ASZ82_03533 ENOG4105C5W Aldolase ASZ82_03534 ENOG4106RE7 Cytochrome ASZ82_03535 ENOG4108IG5 Transcriptional regulator ASZ82_03536 ENOG4105C1J atp-dependent rna helicase ASZ82_03537 ENOG4108ZYK Acyl carrier protein phosphodiesterase ASZ82_03539 ENOG4105E0U tyrosine-specific transport protein ASZ82_03540 ENOG4108N3W hemolysin secretion protein ASZ82_03542 ENOG4105CMR udp-glucose 4-epimerase ASZ82_03544 ENOG4105E7W lamb ycsf family protein ASZ82_03546 ENOG4107R7A Allophanate hydrolase subunit 2 ASZ82_03548 ENOG4105C6Y Udp-glucose 6-dehydrogenase ASZ82_03550 ENOG4105CV6 ABC transporter, permease ASZ82_03551 ENOG4108I0Y (ABC) transporter ASZ82_03552 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) ASZ82_03554 ENOG4105RKW reductase (By ASZ82_03557 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) ASZ82_03566 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) ASZ82_03569 ENOG4107RE1 Inosine-guanosine kinase ASZ82_03570 ENOG4105E0M Sulfatase ASZ82_03572 ENOG4105C1J atp-dependent rna helicase ASZ82_03573 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) ASZ82_03575 ENOG4105CVA phosphate ASZ82_03577 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein ASZ82_03578 ENOG4108M1A Chitin-binding protein ASZ82_03579 ENOG4105D4Y metalloprotease ASZ82_03581 ENOG4105CYW agmatinase ASZ82_03582 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) ASZ82_03585 ENOG4105CJW magnesium transporter ASZ82_03586 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) ASZ82_03587 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) ASZ82_03589 ENOG4105CZK Aspartate kinase ASZ82_03590 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) ASZ82_03591 ENOG4108JPW Aminotransferase ASZ82_03592 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase ASZ82_03593 ENOG41090A4 Pterin carbinolamine dehydratase ASZ82_03594 ENOG4105MIR Phenylalanine 4-monooxygenase ASZ82_03595 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ASZ82_03598 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) ASZ82_03599 ENOG4105EGI Transcriptional regulator ASZ82_03602 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) ASZ82_03603 ENOG4105C37 (CBS) domain ASZ82_03604 ENOG4108UKZ OsmC family ASZ82_03605 ENOG4107YWA deoxycytidylate deaminase ASZ82_03612 ENOG4105DVH amino acid ASZ82_03613 ENOG4106TD9 Diguanylate cyclase ASZ82_03615 ENOG4108VAC response regulator ASZ82_03616 ENOG4108HRK Histidine kinase ASZ82_03619 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ASZ82_03620 ENOG4105C19 ABC transporter ASZ82_03624 ENOG4107RGM aldo keto reductase ASZ82_03625 ENOG4107T9C Alpha amylase catalytic region ASZ82_03628 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation ASZ82_03629 ENOG4108M0H Extracellular lipase ASZ82_03630 ENOG4107SDU Methyl-accepting chemotaxis ASZ82_03631 ENOG4105D4Y metalloprotease ASZ82_03632 ENOG4105EIF outer membrane protein W ASZ82_03634 ENOG41061WM D-Alanyl-D-Alanine ASZ82_03635 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ASZ82_03637 ENOG4105C4M (Ubiquinol oxidase) subunit I ASZ82_03638 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ASZ82_03641 ENOG4105BZC d-serine deaminase ASZ82_03642 ENOG4105W8I Transcriptional regulator ASZ82_03651 ENOG4105CPQ Dehydrogenase ASZ82_03652 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) ASZ82_03653 ENOG4105TMR Functions as a holding molecular chaperone (holdase) which stabilizes unfolding intermediates and rapidly releases them in an active form once stress has abated. Plays an important role in protecting cells from severe heat shock and starvation, as well as in acid resistance of stationary-phase cells. It catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step (By similarity) ASZ82_03655 ENOG4105EXG Transcriptional regulator ASZ82_03656 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase ASZ82_03660 ENOG4107SSZ Phosphatase ASZ82_03661 ENOG4105DHT Metal Dependent Phosphohydrolase ASZ82_03662 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase ASZ82_03663 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) ASZ82_03664 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) ASZ82_03669 ENOG4105BZW Glycerate kinase ASZ82_03670 ENOG4105C6Z Gluconate ASZ82_03671 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR ASZ82_03672 ENOG4108NVR Methyl-accepting chemotaxis ASZ82_03673 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related ASZ82_03674 ENOG41090JE Utilization Protein ASZ82_03675 ENOG4105D4P Coproporphyrinogen iii oxidase ASZ82_03676 ENOG4105WQ5 TonB family ASZ82_03677 ENOG41090AP transport protein ASZ82_03678 ENOG4106GFD transport protein ASZ82_03679 ENOG4107R4I Periplasmic binding protein ASZ82_03680 ENOG4105EHG Permease protein ASZ82_03681 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) ASZ82_03687 ENOG4105C8Q Methyl-accepting chemotaxis ASZ82_03688 ENOG4105QVC MOSC domain-containing protein ASZ82_03688 ENOG4105QVC MOSC domain-containing protein ASZ82_03689 ENOG4105EKE dihydroorotase ASZ82_03691 ENOG4105KAF membrAne ASZ82_03693 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) ASZ82_03694 ENOG4105CKW Inner membrane protein yedI ASZ82_03695 ENOG4108ESY Metal dependent phosphohydrolase ASZ82_03696 ENOG4105VEQ Cold shock protein ASZ82_03700 ENOG4105EQD regulatoR ASZ82_03702 ENOG4105BZU Histidine kinase ASZ82_03703 ENOG4105E98 transcriptional regulator DeoR family ASZ82_03706 ENOG4105EG2 ABC transporter, permease ASZ82_03707 ENOG4105D56 permease protein ASZ82_03708 ENOG4107FKK extracellular solute-binding protein family 1 ASZ82_03709 ENOG4108IJ9 (ABC) transporter ASZ82_03710 ENOG4108HK0 -acetyltransferase ASZ82_03713 ENOG4105K8R UPF0145 protein ASZ82_03714 ENOG41086KC Transcriptional regulator ASZ82_03715 ENOG4105KQ5 peptidylprolyl cis-trans isomerase ASZ82_03716 ENOG4107R88 Chemotaxis protein (CheV) ASZ82_03717 ENOG4105K56 Transcriptional regulator ASZ82_03718 ENOG4106TD9 Diguanylate cyclase ASZ82_03721 ENOG4105BZU Histidine kinase ASZ82_03725 ENOG4105ETT transcriptional Regulator, LysR family ASZ82_03726 ENOG4108K0B C-di-gmp phosphodiesterase ASZ82_03728 ENOG4105EUB pirin domain protein ASZ82_03729 ENOG4105NBK UPF0345 protein ASZ82_03731 ENOG4105E5W Transporter ASZ82_03733 ENOG4105C8Q Methyl-accepting chemotaxis ASZ82_03735 ENOG4105DAN ATP-dependent protease ASZ82_03737 ENOG4108JQ5 ABC transporter ASZ82_03738 ENOG4105E89 ABC transporter ASZ82_03739 ENOG4105C8Q Methyl-accepting chemotaxis ASZ82_03741 ENOG4105CC0 LysR family Transcriptional regulator ASZ82_03743 ENOG4105DAA L-lactate ASZ82_03744 ENOG4105DMF Dehydrogenase ASZ82_03746 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) ASZ82_03748 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor ASZ82_03750 ENOG4105C1J atp-dependent rna helicase ASZ82_03752 ENOG4105CR8 Transcriptional regulator ASZ82_03754 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ASZ82_03756 ENOG4105BZ1 (ABC) transporter ASZ82_03758 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ASZ82_03765 ENOG4105K56 Transcriptional regulator ASZ82_03766 ENOG4108ZHJ Organic hydroperoxide resistance protein ASZ82_03769 ENOG4108SXK Transporter Drug Metabolite Exporter family ASZ82_03770 ENOG4105VW4 glutaredoxin 3 ASZ82_03771 ENOG4108P2H Inner membrane protein YjiG ASZ82_03772 ENOG41074DU domain protein ASZ82_03773 ENOG4105DN9 Na H antiporter ASZ82_03775 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) ASZ82_03776 ENOG4105D03 DNA-3-methyladenine glycosylase II ASZ82_03777 ENOG4108VGI doxx family ASZ82_03782 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) ASZ82_03784 ENOG4107W52 maltose operon periplasmic protein ASZ82_03785 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) ASZ82_03788 ENOG4105C8Q Methyl-accepting chemotaxis ASZ82_03791 ENOG4105C8Q Methyl-accepting chemotaxis ASZ82_03793 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) ASZ82_03794 ENOG4105CDA abc transporter atp-binding protein ASZ82_03796 ENOG4106TNF Periplasmic binding protein ASZ82_03797 ENOG4105EZ7 amino acid ABC transporter ASZ82_03798 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain ASZ82_03800 ENOG4105DR5 peptidase ASZ82_03802 ENOG4105CTS PTS system mannitol-specific ASZ82_03803 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase ASZ82_03804 ENOG4105E61 Mannitol repressor protein ASZ82_03805 ENOG4105EP9 oxidoreductase ASZ82_03811 ENOG4108RYK Nad-dependent epimerase dehydratase ASZ82_03812 ENOG4105JQN Transcriptional regulator ASZ82_03813 ENOG41069D7 Methyl-accepting chemotaxis ASZ82_03814 ENOG4105EMU Dehydrogenase ASZ82_03815 ENOG4105JQN Transcriptional regulator ASZ82_03817 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) ASZ82_03819 ENOG4105D5Q Arginine ornithine antiporter ASZ82_03820 ENOG4105CXN decarboxylase ASZ82_03824 ENOG4107RGH Aldehyde dehydrogenase ASZ82_03825 ENOG4105EW9 transcriptional regulator AsnC family ASZ82_03826 ENOG4105C8Q Methyl-accepting chemotaxis ASZ82_03828 ENOG4105CK7 Sodium proline symporter ASZ82_03830 ENOG4105C26 Dehydrogenase ASZ82_03834 ENOG4105E6M Sulphatase-modifying factor protein ASZ82_03836 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) ASZ82_03837 ENOG4107QZV Type I secretion membrane fusion protein ASZ82_03840 ENOG4108JJA ABC, transporter ASZ82_03842 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ASZ82_03844 ENOG4105C8Q Methyl-accepting chemotaxis ASZ82_03845 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) ASZ82_03846 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) ASZ82_03847 ENOG4105BZU Histidine kinase ASZ82_03848 ENOG4105C8Q Methyl-accepting chemotaxis ASZ82_03849 ENOG4108V3W Chemotaxis protein, CheW ASZ82_03850 ENOG4108V3W Chemotaxis protein, CheW ASZ82_03851 ENOG4105CBS Chea signal transduction histidine kinase ASZ82_03852 ENOG4108VYJ response regulator receiver protein ASZ82_03855 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ASZ82_03856 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ASZ82_03857 ENOG4108JQ6 ABC transporter ASZ82_03858 ENOG4105DIJ Phosphoethanolamine transferase ASZ82_03859 ENOG4105DHQ Histidine kinase ASZ82_03860 ENOG4105XJC Two component transcriptional regulator (Winged helix family ASZ82_03866 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) ASZ82_03867 ENOG4107RUE extracellular solute-binding protein family 1 ASZ82_03868 ENOG4106RMF ParB family