locus-tag class description ASZ87_00018 ENOG4108NYK Tape measure protein ASZ87_00026 ENOG4105C0D helicase ASZ87_00027 ENOG4105DFP Integrase ASZ87_00028 ENOG4105DFP Integrase ASZ87_00033 ENOG4105DY2 Paraquat-inducible protein b ASZ87_00034 ENOG4105F1S paraquat-inducible protein a ASZ87_00039 ENOG4108R86 Transcriptional regulator ASZ87_00040 ENOG4105C26 Dehydrogenase ASZ87_00041 ENOG4105MTM Protein of unknown function (DUF1496) ASZ87_00043 ENOG41067SE Tetr family transcriptional regulator ASZ87_00044 ENOG4107QPN acyl-Coa dehydrogenase ASZ87_00046 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) ASZ87_00047 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate ASZ87_00048 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) ASZ87_00049 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase ASZ87_00050 ENOG4105RKX Protein of unknown function (DUF2498) ASZ87_00051 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) ASZ87_00052 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) ASZ87_00053 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) ASZ87_00057 ENOG4105HP8 regulator of competence-specific genes ASZ87_00058 ENOG4105ETE Transcriptional regulator (LacI family ASZ87_00059 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) ASZ87_00060 ENOG4106WF9 DNA-binding transcriptional regulator TorR ASZ87_00061 ENOG4107S90 membrAne ASZ87_00062 ENOG4106371 Methyltransferase ASZ87_00063 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) ASZ87_00064 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) ASZ87_00065 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) ASZ87_00066 ENOG4105EW9 transcriptional regulator AsnC family ASZ87_00068 ENOG4105CCT upf0313 protein ASZ87_00069 ENOG4105BZU Histidine kinase ASZ87_00073 ENOG4105DZ2 Transcriptional regulator ASZ87_00074 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) ASZ87_00076 ENOG4105K9H YciI-like protein ASZ87_00077 ENOG4105NAU thioesterase Superfamily protein ASZ87_00078 ENOG4107835 probably involved in intracellular septation (By similarity) ASZ87_00080 ENOG4105GFG DUF218 domain ASZ87_00081 ENOG4108535 NAD dependent epimerase/dehydratase family ASZ87_00083 ENOG4105TMB Formate nitrite transporter ASZ87_00086 ENOG4107QY8 reductase ASZ87_00090 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase ASZ87_00093 ENOG4108JQ2 peptide transport system atp-binding protein ASZ87_00094 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein ASZ87_00095 ENOG4108EU3 peptide transport system, permease ASZ87_00096 ENOG4108I5W peptide transport system, permease protein ASZ87_00097 ENOG4108J59 Extracellular solute-binding protein, family 5 ASZ87_00098 ENOG4105E51 psp operon transcriptional activator ASZ87_00099 ENOG41087YS Phage shock protein A ASZ87_00102 ENOG4105C1P efflux transporter, rnd family, mfp subunit ASZ87_00105 ENOG4108R3E Dna-3-methyladenine glycosylase i ASZ87_00106 ENOG4105C28 cystathionine ASZ87_00107 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) ASZ87_00108 ENOG4105C8J )-transporter ASZ87_00109 ENOG4108W1A pseudouridine synthase ASZ87_00110 ENOG4108T9J Cdp-alcohol phosphatidyltransferase ASZ87_00111 ENOG4108VGW abc transporter atp-binding protein ASZ87_00112 ENOG4105CXZ ABC transporter, permease ASZ87_00113 ENOG4105VNH ABC transporter solute-binding protein ASZ87_00115 ENOG4105XZD Fe-S protein ASZ87_00117 ENOG4107QWP ABC-2 type transporter ASZ87_00118 ENOG4105CJ1 ABC, transporter ASZ87_00120 ENOG4105C44 Serine transporter ASZ87_00123 ENOG4105CJW magnesium transporter ASZ87_00124 ENOG4105BZU Histidine kinase ASZ87_00125 ENOG4105BZU Histidine kinase ASZ87_00127 ENOG4105KXC Collagenase ASZ87_00133 ENOG4108N3W hemolysin secretion protein ASZ87_00136 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) ASZ87_00140 ENOG4105CFI type iii restriction protein res subunit ASZ87_00141 ENOG4105I08 Pseudouridine synthase ASZ87_00142 ENOG4105C2C drug resistance transporter, Bcr CflA ASZ87_00144 ENOG4105CGD Nad-dependent epimerase dehydratase ASZ87_00145 ENOG4105UQX Mate efflux family protein ASZ87_00146 ENOG4108I0Y (ABC) transporter ASZ87_00149 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) ASZ87_00151 ENOG4105E3Q saccharopine dehydrogenase ASZ87_00152 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) ASZ87_00153 ENOG4105CDV Ompa motb domain protein ASZ87_00154 ENOG4105DFG type I secretion outer membrane protein ASZ87_00158 ENOG4105F04 LysR family Transcriptional regulator ASZ87_00160 ENOG4108VKG metal-dependent hydrolase ASZ87_00163 ENOG41090FY type IV pilus biogenesis stability protein PilW ASZ87_00164 ENOG4105CVG Homoserine O-transsuccinylase ASZ87_00168 ENOG4107V40 secretion protein, HlyD family ASZ87_00171 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism ASZ87_00172 ENOG4106YYS transcriptional regulatory protein ASZ87_00174 ENOG4107R88 Chemotaxis protein (CheV) ASZ87_00177 ENOG4105BZU Histidine kinase ASZ87_00182 ENOG4105F0Z galactose-1-phosphate uridylyltransferase ASZ87_00183 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) ASZ87_00184 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) ASZ87_00185 ENOG4106TD9 Diguanylate cyclase ASZ87_00186 ENOG4105BZU Histidine kinase ASZ87_00188 ENOG4105C7K acetolactate synthase ASZ87_00189 ENOG4107FQX Alpha-acetolactate decarboxylase ASZ87_00192 ENOG4105CH6 catalase ASZ87_00194 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ASZ87_00196 ENOG4108TWJ NADH dehydrogenase subunit 5 ASZ87_00197 ENOG4105DUM transcriptional regulator, lysR family ASZ87_00198 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) ASZ87_00204 ENOG4105C9Q fumarate hydratase class II ASZ87_00206 ENOG4105C4M (Ubiquinol oxidase) subunit I ASZ87_00207 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ASZ87_00208 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) ASZ87_00209 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ASZ87_00210 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ASZ87_00212 ENOG4107QZV Type I secretion membrane fusion protein ASZ87_00215 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) ASZ87_00216 ENOG4105CS2 ec 3.2.1.21 ASZ87_00217 ENOG4105DDV Transcriptional regulator (LacI family ASZ87_00218 ENOG4105M4H endoribonuclease L-psp ASZ87_00219 ENOG4105XEP YhcH YjgK YiaL family protein ASZ87_00220 ENOG4107VXM glycerophosphoryl diester phosphodiesterase ASZ87_00221 ENOG4105E98 transcriptional regulator DeoR family ASZ87_00222 ENOG4108IJ9 (ABC) transporter ASZ87_00223 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component ASZ87_00229 ENOG4109015 Biopolymer transport protein exbD tolR ASZ87_00230 ENOG41067XB TonB family ASZ87_00234 ENOG4107QI1 Mate efflux family protein ASZ87_00236 ENOG4105FGM Fructosamine kinase ASZ87_00238 ENOG4107TT5 NLP P60 protein ASZ87_00239 ENOG4105C8Q Methyl-accepting chemotaxis ASZ87_00241 ENOG4106IUH DTW domain containing protein ASZ87_00242 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) ASZ87_00246 ENOG4105CVM Molybdenum cofactor synthesis domain protein ASZ87_00247 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) ASZ87_00248 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ASZ87_00249 ENOG4107A5B Binding-protein-dependent transport systems, inner membrane component ASZ87_00251 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASZ87_00252 ENOG4105BZU Histidine kinase ASZ87_00253 ENOG4105C5H ABC transporter ASZ87_00254 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) ASZ87_00258 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) ASZ87_00260 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ASZ87_00261 ENOG4105QAX Iron-sulfur ASZ87_00264 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) ASZ87_00266 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) ASZ87_00269 ENOG4105QNR S1 RNA binding domain protein ASZ87_00270 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B ASZ87_00271 ENOG4105DY2 Paraquat-inducible protein b ASZ87_00272 ENOG4105H2K paraquat-inducible protein a ASZ87_00273 ENOG4105BZ1 (ABC) transporter ASZ87_00274 ENOG4108ZGC gaf domain protein ASZ87_00275 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) ASZ87_00276 ENOG4105CN1 protease ASZ87_00278 ENOG4105CD8 aminopeptidase N ASZ87_00280 ENOG4105C7I Dehydrogenase ASZ87_00281 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) ASZ87_00282 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) ASZ87_00284 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) ASZ87_00286 ENOG4105C5H ABC transporter ASZ87_00289 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) ASZ87_00290 ENOG4105DAN ATP-dependent protease ASZ87_00291 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) ASZ87_00308 ENOG4105TIV Cryptic phage CTXphi transcriptional repressor RstR ASZ87_00315 ENOG4105MQ5 zona occludens toxin ASZ87_00316 ENOG4107927 Cholera enterotoxin, A subunit ASZ87_00318 ENOG4105TIV Cryptic phage CTXphi transcriptional repressor RstR ASZ87_00322 ENOG4105TIV Cryptic phage CTXphi transcriptional repressor RstR ASZ87_00329 ENOG4105MQ5 zona occludens toxin ASZ87_00330 ENOG4107927 Cholera enterotoxin, A subunit ASZ87_00332 ENOG4105EUK rtx toxin RtxA ASZ87_00333 ENOG4108RC6 RTX toxin ASZ87_00338 ENOG4105BZU Histidine kinase ASZ87_00341 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i ASZ87_00344 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) ASZ87_00346 ENOG4105C59 p-type ATPase ASZ87_00349 ENOG4105DS0 Transcriptional regulator, Crp Fnr family ASZ87_00350 ENOG4105Q9Y Universal stress protein ASZ87_00351 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) ASZ87_00355 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ASZ87_00356 ENOG4105F38 ABC transporter, permease ASZ87_00357 ENOG4105D38 putrescine abc transporter ASZ87_00358 ENOG4107RUE extracellular solute-binding protein family 1 ASZ87_00359 ENOG4107RUE extracellular solute-binding protein family 1 ASZ87_00362 ENOG4105BZG amino acid carrier protein ASZ87_00363 ENOG410829K Lysine exporter protein (Lyse ygga) ASZ87_00368 ENOG4105CS6 Rhs element vgr protein ASZ87_00369 ENOG4108WC9 type VI secretion system effector, hcp1 family ASZ87_00370 ENOG4105CTD carboxy-peptidase ASZ87_00371 ENOG4105C8Q Methyl-accepting chemotaxis ASZ87_00372 ENOG4105C0R drug resistance transporter emrb qaca subfamily ASZ87_00373 ENOG4105CW7 secretion protein, HlyD family ASZ87_00374 ENOG4105ENJ RND efflux system, outer membrane lipoprotein ASZ87_00376 ENOG4105C1J atp-dependent rna helicase ASZ87_00377 ENOG4107SDU Methyl-accepting chemotaxis ASZ87_00378 ENOG4108N3W hemolysin secretion protein ASZ87_00379 ENOG4105C8Q Methyl-accepting chemotaxis ASZ87_00380 ENOG4108V3W Chemotaxis protein, CheW ASZ87_00381 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) ASZ87_00383 ENOG4105BZU Histidine kinase ASZ87_00384 ENOG4105CBS Chea signal transduction histidine kinase ASZ87_00385 ENOG4105CBS Chea signal transduction histidine kinase ASZ87_00387 ENOG4108VYJ response regulator receiver protein ASZ87_00388 ENOG4108NVR Methyl-accepting chemotaxis ASZ87_00389 ENOG4105KPY Small multidrug resistance protein ASZ87_00390 ENOG4105CVP deoxyribo-dipyrimidine photolyase ASZ87_00391 ENOG4105C0R drug resistance transporter emrb qaca subfamily ASZ87_00392 ENOG4105EJC lysr family transcriptional regulator ASZ87_00393 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) ASZ87_00394 ENOG4105R8A Heat shock protein ASZ87_00396 ENOG4105CQ7 ATP-dependent helicase ASZ87_00401 ENOG4105BZU Histidine kinase ASZ87_00403 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB ASZ87_00404 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB ASZ87_00405 ENOG4105BZU Histidine kinase ASZ87_00407 ENOG4105BZU Histidine kinase ASZ87_00411 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) ASZ87_00412 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) ASZ87_00414 ENOG410667J hydrolase ASZ87_00416 ENOG4107QXX ABC transporter ASZ87_00417 ENOG4105EZ7 amino acid ABC transporter ASZ87_00418 ENOG4105DRP amino acid AbC transporter ASZ87_00419 ENOG4105CDA abc transporter atp-binding protein ASZ87_00420 ENOG4108MN8 Membrane ASZ87_00421 ENOG4108Z0T Part of a sulfur-relay system (By similarity) ASZ87_00422 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 ASZ87_00423 ENOG4105DR4 Methyltransferase ASZ87_00424 ENOG4106TD9 Diguanylate cyclase ASZ87_00426 ENOG4105BZU Histidine kinase ASZ87_00427 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase ASZ87_00428 ENOG4108RXX maleylacetoacetate isomerase ASZ87_00430 ENOG4105F1J Homogentisate 1,2-dioxygenase ASZ87_00431 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase ASZ87_00432 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) ASZ87_00435 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ASZ87_00436 ENOG4105C7F AcnD-accessory protein PrpF ASZ87_00437 ENOG4108I0Z Aconitate hydratase ASZ87_00438 ENOG4105BZN citrate synthase ASZ87_00439 ENOG4105CR4 methylisocitrate lyase ASZ87_00440 ENOG41073TP transcriptional regulator ASZ87_00446 ENOG4107SDZ Galactoside transport system permease protein mglC ASZ87_00447 ENOG4105C2J ABC transporter ASZ87_00452 ENOG4107EXC regulatoR ASZ87_00453 ENOG4105EB3 Histidine kinase ASZ87_00454 ENOG4105RW8 MltA-interacting MipA family protein ASZ87_00455 ENOG4108MJ5 VirK protein ASZ87_00456 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASZ87_00457 ENOG4105BZU Histidine kinase ASZ87_00458 ENOG4105C8P )-transporter ASZ87_00459 ENOG4108NVR Methyl-accepting chemotaxis ASZ87_00460 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ASZ87_00463 ENOG4105D9U N-acetyltransferase ASZ87_00464 ENOG4108JU8 Transcriptional regulator ASZ87_00466 ENOG4105CM6 amino acid regulated cytosolic protein ASZ87_00469 ENOG4105CRQ synthase (Component I) ASZ87_00470 ENOG4105P8F nudix hydrolase ASZ87_00471 ENOG4105C44 Serine transporter ASZ87_00472 ENOG4105EJQ L-serine dehydratase ASZ87_00473 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase ASZ87_00474 ENOG4108NVR Methyl-accepting chemotaxis ASZ87_00475 ENOG4105C5S asparaginyl-tRNA synthetase ASZ87_00477 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase ASZ87_00478 ENOG4105CGF Aromatic amino acid aminotransferase ASZ87_00482 ENOG4105C8Q Methyl-accepting chemotaxis ASZ87_00483 ENOG4105DJ9 glucan biosynthesis protein ASZ87_00484 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) ASZ87_00485 ENOG41060NJ transcriptional regulator ASZ87_00486 ENOG410901P UPF0249 protein ASZ87_00487 ENOG4105F8D glycoside hydrolase family 4 ASZ87_00488 ENOG4105VCP PTS System ASZ87_00490 ENOG4105VZJ PTS System ASZ87_00492 ENOG4105C94 Transporter ASZ87_00493 ENOG41067TZ transcriptional regulator, MarR family ASZ87_00496 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ASZ87_00498 ENOG4105CH5 extracellular solute-binding protein, family 7 ASZ87_00501 ENOG4105C5X domain protein ASZ87_00502 ENOG4105EAQ (twin-arginine translocation) pathway signal ASZ87_00503 ENOG4105DIT ErfK YbiS YcfS YnhG family protein ASZ87_00508 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) ASZ87_00510 ENOG4105S8Q sugar efflux transporter ASZ87_00512 ENOG4105C72 UPF0176 protein ASZ87_00513 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ASZ87_00514 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) ASZ87_00515 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ASZ87_00516 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ASZ87_00517 ENOG4107QK7 reductase ASZ87_00522 ENOG4105C8Q Methyl-accepting chemotaxis ASZ87_00525 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) ASZ87_00526 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) ASZ87_00529 ENOG4108YZT Adenosylcobinamide kinase ASZ87_00530 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) ASZ87_00531 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) ASZ87_00532 ENOG4105E0X reductase ASZ87_00533 ENOG4108ETY sodium dicarboxylate symporter ASZ87_00534 ENOG4105CJB Exodeoxyribonuclease I ASZ87_00536 ENOG41067MG lrgb family ASZ87_00537 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) ASZ87_00539 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR ASZ87_00540 ENOG4105FQ6 thiopurine methyltransferase ASZ87_00543 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) ASZ87_00544 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) ASZ87_00545 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) ASZ87_00547 ENOG4105BZU Histidine kinase ASZ87_00553 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) ASZ87_00554 ENOG4105WH1 Two component transcriptional regulator luxr family ASZ87_00555 ENOG4105CQ2 DNA polymerase ASZ87_00556 ENOG4105BZU Histidine kinase ASZ87_00558 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) ASZ87_00561 ENOG4105CZE histidine utilization repressor ASZ87_00562 ENOG4105CI2 imidazolone-5-propionate hydrolase ASZ87_00563 ENOG41088SP formiminoglutamate hydrolase ASZ87_00564 ENOG4105CGP Urocanate hydratase ASZ87_00565 ENOG4105C84 Histidine ammonia-lyase ASZ87_00567 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap ASZ87_00569 ENOG4105CQB FAD linked oxidase domain protein ASZ87_00572 ENOG4108ZG0 Ompa motb domain protein ASZ87_00576 ENOG4105C8V SAICAR synthetase ASZ87_00578 ENOG4107R1I NAD-dependent malic enzyme ASZ87_00580 ENOG4107GZ4 SanA protein ASZ87_00581 ENOG4105BZU Histidine kinase ASZ87_00582 ENOG4105C9B Cysteine desulfurase ASZ87_00584 ENOG4105C3M thioredoxin reductase ASZ87_00585 ENOG4108JJ9 ABC, transporter ASZ87_00586 ENOG4108JJ8 (ABC) transporter ASZ87_00587 ENOG4105FE9 pseudouridine synthase ASZ87_00588 ENOG4107RTD sua5 ycio yrdc ywlc family protein ASZ87_00589 ENOG4105DB7 PHP domain protein ASZ87_00590 ENOG4105CRQ synthase (Component I) ASZ87_00591 ENOG4105DDQ anthranilate synthase ASZ87_00592 ENOG4108I0Q anthranilate phosphoribosyltransferase ASZ87_00593 ENOG4105DK0 Indole-3-glycerol phosphate synthase ASZ87_00594 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) ASZ87_00595 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) ASZ87_00596 ENOG4105CK2 sodium dicarboxylate symporter ASZ87_00597 ENOG4107104 thymidine kinase ASZ87_00598 ENOG4105C9M aspartyl-trna synthetase ASZ87_00599 ENOG41081XQ Conserved Protein ASZ87_00600 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) ASZ87_00601 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) ASZ87_00602 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) ASZ87_00605 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) ASZ87_00607 ENOG4105CUX Signal transduction histidine kinase ASZ87_00612 ENOG4105DWU Membrane ASZ87_00614 ENOG4105DY8 decarboxylase ASZ87_00615 ENOG4106KNT transcriptional regulator ASZ87_00616 ENOG4108EKI Dehydrogenase ASZ87_00617 ENOG41090BQ Glutaredoxin ASZ87_00619 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ASZ87_00620 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) ASZ87_00621 ENOG4105VEQ Cold shock protein ASZ87_00623 ENOG4108R99 pseudouridine synthase ASZ87_00624 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase ASZ87_00625 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) ASZ87_00626 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase ASZ87_00627 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) ASZ87_00628 ENOG4105ECC imidazole-glycerol-phosphate dehydratase ASZ87_00629 ENOG4105CIH Imidazole acetol-phosphate transaminase ASZ87_00630 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) ASZ87_00631 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) ASZ87_00632 ENOG4107S6Z Na H antiporter ASZ87_00634 ENOG4107RE1 Inosine-guanosine kinase ASZ87_00635 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) ASZ87_00636 ENOG41075W9 High frequency lysogenization protein HflD homolog ASZ87_00637 ENOG4107QTF adenylosuccinate lyase ASZ87_00639 ENOG4105RHG ASZ87_00641 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase ASZ87_00644 ENOG4107FW0 short-chain dehydrogenase reductase ASZ87_00646 ENOG4105D0M Protease HtpX homolog ASZ87_00648 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) ASZ87_00649 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) ASZ87_00650 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) ASZ87_00651 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) ASZ87_00652 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) ASZ87_00653 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) ASZ87_00654 ENOG4105D1H recombination factor protein RarA ASZ87_00656 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving ASZ87_00657 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) ASZ87_00658 ENOG4105BZU Histidine kinase ASZ87_00659 ENOG4108JJB ABC transporter ASZ87_00660 ENOG4105C7J ABC transporter, permease ASZ87_00662 ENOG4105VYA Uncharacterized conserved protein (DUF2132) ASZ87_00663 ENOG4105PQ6 UPF0208 membrane protein ASZ87_00664 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) ASZ87_00665 ENOG4108DNC Involved in acetate metabolism (By similarity) ASZ87_00666 ENOG4105CHF Glutathione S-transferase ASZ87_00667 ENOG4108JQ7 (ABC) transporter ASZ87_00668 ENOG4105C3U ABC transporter ASZ87_00669 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ASZ87_00670 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ASZ87_00671 ENOG4107QSI ABC, transporter ASZ87_00674 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASZ87_00675 ENOG4105BZU Histidine kinase ASZ87_00676 ENOG4105BZU Histidine kinase ASZ87_00677 ENOG4105BZU Histidine kinase ASZ87_00679 ENOG4107YTP response regulator receiver protein ASZ87_00682 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) ASZ87_00685 ENOG4108V1U phospholipid-binding protein ASZ87_00690 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase ASZ87_00691 ENOG41082YX Transcriptional regulator, arsr family ASZ87_00692 ENOG4105BZU Histidine kinase ASZ87_00696 ENOG4105C29 acyl-CoA thioesterase ASZ87_00697 ENOG4108XM1 transcriptional regulator AsnC family ASZ87_00699 ENOG4105ERU peptidase ASZ87_00700 ENOG4105UBK short-chain dehydrogenase reductase ASZ87_00702 ENOG4105KRS Proteinase inhibitor ASZ87_00703 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) ASZ87_00704 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) ASZ87_00705 ENOG4107QMP dna polymerase iii subunits gamma and tau ASZ87_00706 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) ASZ87_00707 ENOG4105WD1 Membrane ASZ87_00709 ENOG4105I93 response regulator ASZ87_00710 ENOG4105EJC lysr family transcriptional regulator ASZ87_00711 ENOG41069NU Nitroreductase ASZ87_00712 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ASZ87_00713 ENOG4105CHU acetyl-coa acetyltransferase ASZ87_00716 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation ASZ87_00717 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation ASZ87_00719 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase ASZ87_00720 ENOG4108GAE asmA family ASZ87_00721 ENOG4105DBI uridine monophosphokinase ASZ87_00722 ENOG4105D1F ATP-binding protein ASZ87_00723 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) ASZ87_00725 ENOG4108I5U Uridine phosphorylase ASZ87_00728 ENOG4105BZU Histidine kinase ASZ87_00729 ENOG4108ZAF Molybdopterin ASZ87_00730 ENOG4105M00 molybdopterin converting factor, subunit 1 ASZ87_00731 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) ASZ87_00732 ENOG4108RIR Molybdenum cofactor biosynthesis protein ASZ87_00733 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) ASZ87_00734 ENOG4105CHW UPF0052 protein ASZ87_00736 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASZ87_00737 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) ASZ87_00740 ENOG4108R3D Electron transport complex ASZ87_00742 ENOG4105D6A Electron transport complex ASZ87_00743 ENOG4108UQQ Electron transport complex ASZ87_00744 ENOG4105DZB Electron transport complex ASZ87_00745 ENOG4105CSM endonuclease III ASZ87_00746 ENOG4108UYE Lactoylglutathione lyase ASZ87_00747 ENOG4106WH9 Protein of unknown function (DUF2753) ASZ87_00748 ENOG4105EIY sodium-type flagellar protein motY ASZ87_00749 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) ASZ87_00750 ENOG4105D3Y Na H antiporter ASZ87_00751 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase ASZ87_00752 ENOG4105E96 Colicin v production protein ASZ87_00753 ENOG4108S3P Sporulation domain protein ASZ87_00754 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase ASZ87_00755 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) ASZ87_00756 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) ASZ87_00758 ENOG4105CX6 glutaminyL-tRNA synthetase ASZ87_00759 ENOG4105CI1 PTS System ASZ87_00760 ENOG4105CE4 GlcNAc 6-P deacetylase ASZ87_00761 ENOG4105E2R ROK family ASZ87_00762 ENOG4105CKD glutathione-regulated potassium-efflux system protein ASZ87_00763 ENOG4105CAQ asparagine synthetase ASZ87_00764 ENOG4105MDZ Transcriptional activator rfaH ASZ87_00765 ENOG4105DUX Transporter ASZ87_00766 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) ASZ87_00767 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) ASZ87_00768 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) ASZ87_00769 ENOG4108TU9 TRANSCRIPTIONal ASZ87_00772 ENOG4108RE9 Phosphodiesterase ASZ87_00773 ENOG4105ECP epimerase ASZ87_00774 ENOG4105E1F short-chain dehydrogenase reductase ASZ87_00775 ENOG4107QR8 Thioredoxin ASZ87_00776 ENOG4107QX8 SPFH domain, Band 7 family protein ASZ87_00777 ENOG4105G5H Membrane ASZ87_00778 ENOG4108Z6Z Transcriptional regulator ASZ87_00780 ENOG41081QG Porin Gram-negative type ASZ87_00781 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) ASZ87_00782 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) ASZ87_00783 ENOG4105EXN Sulfate transport protein CysZ ASZ87_00784 ENOG4105C6T cysteine synthase ASZ87_00785 ENOG4105KZ7 phosphocarrier protein hpr ASZ87_00787 ENOG4105C5Y PTS System ASZ87_00788 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family ASZ87_00789 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) ASZ87_00790 ENOG4105C9A Phoh family ASZ87_00791 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) ASZ87_00792 ENOG4108JU5 Magnesium and cobalt efflux protein ASZ87_00793 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) ASZ87_00794 ENOG4107PAI alpha helical protein ASZ87_00795 ENOG4105C8T Leucyl-tRNA synthetase ASZ87_00796 ENOG4108U2H Rare lipoprotein B ASZ87_00797 ENOG4105DJF DNA polymerase III, delta' subunit ASZ87_00798 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) ASZ87_00799 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) ASZ87_00800 ENOG4105CJN penicillin-binding protein ASZ87_00801 ENOG4105CNI cell division protein FtsW ASZ87_00802 ENOG4105K6T rare lipoprotein A ASZ87_00803 ENOG4105DZ1 carboxypeptidase ASZ87_00804 ENOG4108Z43 UPF0250 protein ASZ87_00805 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) ASZ87_00806 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) ASZ87_00808 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) ASZ87_00812 ENOG4105D75 Capsular exopolysaccharide family ASZ87_00813 ENOG4105DAY polysaccharide export protein ASZ87_00815 ENOG4105D3Q Sugar transferase ASZ87_00818 ENOG4108MA4 Peptidase M66 ASZ87_00821 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family ASZ87_00823 ENOG4105Q84 sucrose synthase ASZ87_00825 ENOG4105D7W serine acetyltransferase ASZ87_00829 ENOG4108UW5 maltose o-acetyltransferase ASZ87_00831 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase ASZ87_00834 ENOG4105BZS acriflavin resistance protein ASZ87_00840 ENOG4105CG3 alpha amylase, catalytic region ASZ87_00841 ENOG4105C5Y PTS System ASZ87_00842 ENOG4105D4X repressor ASZ87_00843 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase ASZ87_00844 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) ASZ87_00845 ENOG4108UMI ABC transporter, permease ASZ87_00846 ENOG4105D01 (LipO)protein ASZ87_00847 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein ASZ87_00848 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) ASZ87_00849 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) ASZ87_00851 ENOG4105BZU Histidine kinase ASZ87_00852 ENOG4105EWT decarboxylase family ASZ87_00853 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease ASZ87_00854 ENOG4105M08 Membrane ASZ87_00855 ENOG4105ETT transcriptional Regulator, LysR family ASZ87_00856 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) ASZ87_00857 ENOG4106VK6 Flagellar motor protein ASZ87_00858 ENOG4105E14 MotA TolQ exbB proton channel ASZ87_00860 ENOG4105CTB Polyprenyl synthetase ASZ87_00861 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) ASZ87_00862 ENOG4105DR9 pseudouridine synthase ASZ87_00863 ENOG4105WP7 tRNA pseudouridine synthase C ASZ87_00866 ENOG4108428 Inherit from COG: -acetyltransferase ASZ87_00868 ENOG4108UPT UPF0178 protein ASZ87_00869 ENOG4105CFC Transporter ASZ87_00871 ENOG4105NRA 50s ribosomal protein l31 type b ASZ87_00872 ENOG4108R96 Methyltransferase, YaeB family ASZ87_00873 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) ASZ87_00877 ENOG4108RS6 transposase ASZ87_00878 ENOG4107QIK phosphoribosylformylglycinamidine synthase ASZ87_00879 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) ASZ87_00881 ENOG4108Z6B deaminase ASZ87_00882 ENOG4105CFC Transporter ASZ87_00888 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) ASZ87_00889 ENOG4105CFG Acts as a chaperone (By similarity) ASZ87_00890 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ ASZ87_00891 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) ASZ87_00892 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) ASZ87_00893 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) ASZ87_00894 ENOG4105VDB UPF0125 protein ASZ87_00895 ENOG4108Z1B Cyclase dehydrase ASZ87_00896 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) ASZ87_00898 ENOG4105DFP Integrase ASZ87_00899 ENOG4105F88 accessory colonization factor AcfD ASZ87_00901 ENOG4105DR5 peptidase ASZ87_00905 ENOG4105C8Q Methyl-accepting chemotaxis ASZ87_00906 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) ASZ87_00909 ENOG4108VEY type ii secretion system ASZ87_00910 ENOG4107QHF type ii secretion system protein e ASZ87_00914 ENOG4105GRU toxin co-regulated pilus biosynthesis outer membrane protein C ASZ87_00917 ENOG4105XB6 Toxin coregulated pilin ASZ87_00920 ENOG4107RK6 Methyl-accepting chemotaxis ASZ87_00921 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) ASZ87_00925 ENOG4105C26 Dehydrogenase ASZ87_00936 ENOG4105DZ0 fad dependent oxidoreductase ASZ87_00937 ENOG4108Z4U Ferredoxin ASZ87_00940 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase ASZ87_00941 ENOG4105YGP holo-ACP synthase CitX ASZ87_00942 ENOG4105CHY citrate lyase, alpha ASZ87_00943 ENOG4105CI0 Citrate lyase ASZ87_00944 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) ASZ87_00945 ENOG4105DUA (citrate (pro-3S)-lyase ligase ASZ87_00948 ENOG4107QSA Oxaloacetate decarboxylase ASZ87_00949 ENOG4105D9Q decarboxylase (Beta subunit) ASZ87_00950 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism ASZ87_00951 ENOG4106YYS transcriptional regulatory protein ASZ87_00955 ENOG4105MWK D-amino acid dehydrogenase, small subunit ASZ87_00956 ENOG4105BZG amino acid carrier protein ASZ87_00957 ENOG4105EUZ Beta-lactamase domain protein ASZ87_00958 ENOG41064T2 transcriptional regulator, lysR family ASZ87_00960 ENOG4105E0A ABC, transporter ASZ87_00961 ENOG4105TVJ transport system, permease ASZ87_00962 ENOG4105DQ5 transport system permease protein ASZ87_00963 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein ASZ87_00965 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase ASZ87_00966 ENOG4105E4F Isochorismate synthase ASZ87_00967 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase ASZ87_00968 ENOG4105WQI isochorismatase ASZ87_00969 ENOG4106HK8 GPR1 FUN34 yaaH family protein ASZ87_00971 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) ASZ87_00972 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) ASZ87_00973 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) ASZ87_00976 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) ASZ87_00977 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) ASZ87_00978 ENOG4105N21 Membrane ASZ87_00979 ENOG4105CUT histidyl-tRNA synthetase ASZ87_00980 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) ASZ87_00982 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs ASZ87_00983 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) ASZ87_00984 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) ASZ87_00985 ENOG4105WVQ Fe-S assembly protein IscX ASZ87_00986 ENOG4108ZIT Ferredoxin, 2FE-2S ASZ87_00987 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB ASZ87_00988 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) ASZ87_00989 ENOG4108Z4V iron-sulfur cluster assembly ASZ87_00990 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins ASZ87_00991 ENOG4105C3J Cysteine desulfurase ASZ87_00992 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family ASZ87_00993 ENOG4105CVS RNA methyltransferase TrmH family, group 1 ASZ87_00994 ENOG4105ECY inositol monophosphatase ASZ87_00995 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ASZ87_00996 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ASZ87_00997 ENOG4105VIE preprotein translocase, subunit YajC ASZ87_00998 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) ASZ87_00999 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) ASZ87_01000 ENOG4105W87 Cbs domain ASZ87_01001 ENOG4108I9X Isocitrate lyase ASZ87_01002 ENOG4107QP3 malate synthase g ASZ87_01003 ENOG4105C5Q Transcriptional regulator ASZ87_01004 ENOG4105D3R alkyl hydroperoxide reductase ASZ87_01005 ENOG4106N3A copper homeostasis protein cutc ASZ87_01006 ENOG4105CSR polyphosphate kinase 2 ASZ87_01008 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) ASZ87_01009 ENOG4105E2Z phosphate ABC transporter (Permease ASZ87_01010 ENOG4105C8U phosphate abc transporter ASZ87_01011 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) ASZ87_01012 ENOG4105C9X ppx gppa phosphatase ASZ87_01014 ENOG4105BZU Histidine kinase ASZ87_01015 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ASZ87_01016 ENOG4105DH7 May be involved in recombination (By similarity) ASZ87_01017 ENOG4105CFP Peptidase U32 ASZ87_01018 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding ASZ87_01026 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ASZ87_01027 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase ASZ87_01028 ENOG4105C34 Pseudouridine synthase ASZ87_01029 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane ASZ87_01030 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA ASZ87_01032 ENOG4107XW0 Spermidine putrescine ABC transporter periplasmic spermidine putrescine-binding protein ASZ87_01033 ENOG4108K0B C-di-gmp phosphodiesterase ASZ87_01034 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) ASZ87_01035 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) ASZ87_01036 ENOG4107SC1 transglycosylase ASZ87_01037 ENOG4105C5H ABC transporter ASZ87_01040 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) ASZ87_01041 ENOG4108HRK Histidine kinase ASZ87_01042 ENOG4108NEV two component transcriptional regulator, LytTR family ASZ87_01043 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) ASZ87_01044 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) ASZ87_01045 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate ASZ87_01049 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) ASZ87_01050 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase ASZ87_01051 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) ASZ87_01052 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) ASZ87_01053 ENOG4105DTN riboflavin biosynthesis protein ribF ASZ87_01054 ENOG4105CJR Integral membrane protein (MviN ASZ87_01055 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) ASZ87_01056 ENOG41080HT Transcriptional regulator, arsr family ASZ87_01057 ENOG41063Z6 transcriptional regulator, lysR family ASZ87_01060 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) ASZ87_01061 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) ASZ87_01062 ENOG4105HF0 Membrane ASZ87_01063 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase ASZ87_01064 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) ASZ87_01065 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) ASZ87_01066 ENOG4105CPC Aldo Keto reductase ASZ87_01068 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASZ87_01069 ENOG4105CRK lysyL-tRNA synthetase ASZ87_01070 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) ASZ87_01071 ENOG4105CWM branched-chain amino acid transport system II carrier protein ASZ87_01072 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) ASZ87_01073 ENOG4105C1J atp-dependent rna helicase ASZ87_01074 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) ASZ87_01075 ENOG4105BZU Histidine kinase ASZ87_01078 ENOG4108YYD acetyltransferase ASZ87_01079 ENOG4105XPQ lipid carrier protein ASZ87_01080 ENOG4105BZU Histidine kinase ASZ87_01081 ENOG4105CFP Peptidase U32 ASZ87_01082 ENOG4106RZ4 Peptidase U32 ASZ87_01085 ENOG4105RT1 May be involved in cell division (By similarity) ASZ87_01086 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) ASZ87_01087 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) ASZ87_01088 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) ASZ87_01089 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) ASZ87_01090 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) ASZ87_01091 ENOG4105CHV Transcription elongation factor NusA ASZ87_01092 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) ASZ87_01097 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) ASZ87_01098 ENOG4105EEI dihydropteroate synthase ASZ87_01099 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) ASZ87_01100 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) ASZ87_01101 ENOG4105HBR Rna-binding protein ASZ87_01102 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) ASZ87_01103 ENOG4105FCK Membrane ASZ87_01104 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase ASZ87_01105 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) ASZ87_01106 ENOG4105DR5 peptidase ASZ87_01109 ENOG4108YX9 iron--sulfur cluster insertion protein erpA ASZ87_01110 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase ASZ87_01112 ENOG4105IPI Membrane ASZ87_01113 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) ASZ87_01114 ENOG4105BZU Histidine kinase ASZ87_01115 ENOG4107QRA Extracellular solute-binding protein, family 5 ASZ87_01117 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ASZ87_01118 ENOG4105C3U ABC transporter ASZ87_01119 ENOG4108JQ7 (ABC) transporter ASZ87_01121 ENOG4105RD7 BadF BadG BcrA BcrD ASZ87_01122 ENOG4105E2D ec 3.2.1.52 ASZ87_01123 ENOG4105E2V Glycosyltransferase 36 ASZ87_01125 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ASZ87_01129 ENOG4108YZA Nitrogen regulatory protein pii ASZ87_01130 ENOG4105XTV UPF0231 protein ASZ87_01131 ENOG4107QIJ Aconitate hydratase 2 ASZ87_01132 ENOG4105D78 K07001 NTE family protein ASZ87_01133 ENOG4105BZ4 penicillin-binding protein ASZ87_01134 ENOG4105CQ7 ATP-dependent helicase ASZ87_01136 ENOG4105PW4 Sugar fermentation stimulation protein homolog ASZ87_01137 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters ASZ87_01138 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) ASZ87_01139 ENOG4105DJ0 Poly(A) Polymerase ASZ87_01140 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase ASZ87_01141 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) ASZ87_01142 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) ASZ87_01143 ENOG4105E3A (ABC) transporter ASZ87_01144 ENOG4105DA5 (ABC) transporter ASZ87_01145 ENOG4105CHH sulfate transporter ASZ87_01146 ENOG41077A9 carbonic anhydrase ASZ87_01147 ENOG4108UGV hypoxanthine phosphoribosyltransferase ASZ87_01148 ENOG410630P Transcriptional regulator ASZ87_01149 ENOG410630P Transcriptional regulator ASZ87_01150 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) ASZ87_01151 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) ASZ87_01152 ENOG41082RQ UPF0102 protein ASZ87_01153 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) ASZ87_01154 ENOG4105W4M Transport-associated protein ASZ87_01155 ENOG4105KB2 stringent starvation protein b ASZ87_01156 ENOG4107MKT Stringent starvation protein a ASZ87_01157 ENOG4105EIX cytochrome c1 ASZ87_01158 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) ASZ87_01159 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) ASZ87_01160 ENOG4108UJD 30S ribosomal protein S9 ASZ87_01161 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) ASZ87_01162 ENOG4105D6Z AFG1 family ATPase ASZ87_01164 ENOG4105C0H protease ASZ87_01165 ENOG4105C0H protease ASZ87_01166 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) ASZ87_01167 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) ASZ87_01168 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) ASZ87_01169 ENOG4105K5M 30s ribosomal protein S16 ASZ87_01170 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ASZ87_01171 ENOG4106KVJ cytochrome C assembly protein ASZ87_01172 ENOG4108JU6 CBS domain protein ASZ87_01173 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) ASZ87_01174 ENOG4105D9M gamma-glutamylcysteine synthetase ASZ87_01176 ENOG4105W39 Membrane ASZ87_01178 ENOG4105D9Q decarboxylase (Beta subunit) ASZ87_01179 ENOG4107QSA Oxaloacetate decarboxylase ASZ87_01189 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) ASZ87_01190 ENOG4105CFH Aspartokinase ASZ87_01191 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) ASZ87_01192 ENOG4105Y3E Modulates RecA activity (By similarity) ASZ87_01193 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) ASZ87_01195 ENOG4108IJ6 ABC transporter ASZ87_01196 ENOG4105ECW sulfate abc transporter ASZ87_01197 ENOG4108I5D sulfate abc transporter ASZ87_01198 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein ASZ87_01199 ENOG4105C6T cysteine synthase ASZ87_01200 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) ASZ87_01201 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ASZ87_01202 ENOG4108K5P (LipO)protein ASZ87_01203 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) ASZ87_01204 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) ASZ87_01205 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) ASZ87_01206 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) ASZ87_01207 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) ASZ87_01209 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) ASZ87_01210 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase ASZ87_01211 ENOG4107ZVW dihydroneopterin aldolase ASZ87_01212 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) ASZ87_01214 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) ASZ87_01215 ENOG4105VCC 30S ribosomal protein S21 ASZ87_01216 ENOG4105KTH gatB Yqey ASZ87_01217 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) ASZ87_01218 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ASZ87_01220 ENOG4105DFP Integrase ASZ87_01221 ENOG4105D58 Diguanylate phosphodiesterase ASZ87_01222 ENOG4105C8Q Methyl-accepting chemotaxis ASZ87_01224 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor ASZ87_01226 ENOG4108YGG dna repair protein ASZ87_01232 ENOG4105DR5 peptidase ASZ87_01237 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) ASZ87_01247 ENOG4105CH5 extracellular solute-binding protein, family 7 ASZ87_01248 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) ASZ87_01249 ENOG410804X Transcriptional regulator ASZ87_01250 ENOG4105CA9 Pyruvate kinase ASZ87_01252 ENOG4105MPN Membrane ASZ87_01253 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) ASZ87_01254 ENOG4108ZUB Lysine exporter protein (Lyse ygga) ASZ87_01255 ENOG4105D64 Mechanosensitive ion channel ASZ87_01256 ENOG4105D2N Aldolase ASZ87_01257 ENOG4105BZA Phosphoglycerate kinase ASZ87_01258 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase ASZ87_01259 ENOG4105D05 Receptor ASZ87_01260 ENOG4108R4R Iron-regulated virulence regulatory protein ASZ87_01261 ENOG4105CV1 Transketolase (EC 2.2.1.1) ASZ87_01262 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP ASZ87_01263 ENOG4105GPY SprT protein ASZ87_01264 ENOG4105RWS endonuclease I ASZ87_01265 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) ASZ87_01266 ENOG4105D7Z glutathione synthase ASZ87_01267 ENOG4108UJU UPF0301 protein ASZ87_01268 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) ASZ87_01269 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) ASZ87_01271 ENOG4105CZX twitching motility protein ASZ87_01272 ENOG4105CZX twitching motility protein ASZ87_01273 ENOG4105DFA alanine racemase domain protein ASZ87_01274 ENOG4105II7 pyrroline-5-carboxylate reductase ASZ87_01275 ENOG4108VIA integral membrane protein ASZ87_01276 ENOG4105VZ9 UPF0235 protein ASZ87_01278 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) ASZ87_01279 ENOG4105CSA Coproporphyrinogen iii oxidase ASZ87_01280 ENOG4105CSV Glutaminase ASZ87_01281 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) ASZ87_01282 ENOG4105CEN a g-specific adenine glycosylase ASZ87_01283 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) ASZ87_01284 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division ASZ87_01295 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) ASZ87_01296 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) ASZ87_01297 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) ASZ87_01298 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) ASZ87_01299 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) ASZ87_01300 ENOG4105NWN ApaG protein ASZ87_01301 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) ASZ87_01303 ENOG4107XM3 UPF0442 protein ASZ87_01304 ENOG4105DWK Membrane ASZ87_01305 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control ASZ87_01306 ENOG4105K46 50S ribosomal protein l27 ASZ87_01307 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) ASZ87_01308 ENOG4105EAH synthase ASZ87_01309 ENOG4105D5Q Arginine ornithine antiporter ASZ87_01310 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) ASZ87_01311 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) ASZ87_01314 ENOG41081QV Universal stress protein ASZ87_01318 ENOG4105CEU Arginine dihydrolase ASZ87_01319 ENOG4105D1U peptidase U62 modulator of DNA gyrase ASZ87_01321 ENOG4105QD6 exported protein ASZ87_01322 ENOG4105C03 ribonuclease ASZ87_01323 ENOG4108Z03 MAF-like protein ASZ87_01324 ENOG4105VQ7 Rod shape-determining protein MreD ASZ87_01325 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) ASZ87_01326 ENOG4105DFF Rod shape-determining protein mreb ASZ87_01335 ENOG4105D7Q type ii secretion system ASZ87_01336 ENOG4107QHF type ii secretion system protein e ASZ87_01339 ENOG4105E4G Type IV pilus ASZ87_01343 ENOG41062P1 Diguanylate cyclase phosphodiesterase ASZ87_01344 ENOG4108UUM single-stranded DNA-binding protein ASZ87_01345 ENOG41086KC Transcriptional regulator ASZ87_01346 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase ASZ87_01347 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) ASZ87_01349 ENOG4105C5R Aminotransferase ASZ87_01350 ENOG4105CFH Aspartokinase ASZ87_01351 ENOG4105C3R Methionine synthase ASZ87_01352 ENOG4105EEQ Na H antiporter ASZ87_01359 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) ASZ87_01360 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) ASZ87_01361 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) ASZ87_01364 ENOG4105P4Z Phage shock protein G ASZ87_01365 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) ASZ87_01366 ENOG4105MYN Zinc uptake regulation protein ASZ87_01369 ENOG4107QP8 phosphohexose isomerase ASZ87_01370 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme ASZ87_01371 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ASZ87_01372 ENOG4105CDU Replicative dna helicase ASZ87_01374 ENOG4105K9Q Binds to the 23S rRNA (By similarity) ASZ87_01375 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) ASZ87_01376 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) ASZ87_01377 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) ASZ87_01378 ENOG4108UQY Iron-storage protein ASZ87_01379 ENOG4105W53 bacterioferritin-associated ferredoxin ASZ87_01380 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) ASZ87_01381 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) ASZ87_01382 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) ASZ87_01383 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) ASZ87_01385 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) ASZ87_01386 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) ASZ87_01387 ENOG4105WWK YheO domain protein ASZ87_01388 ENOG4108V1T peptidylprolyl cis-trans isomerase ASZ87_01390 ENOG41069P5 Protein slyX homolog ASZ87_01392 ENOG4105EPW hflc protein ASZ87_01393 ENOG4107QJR hflk protein ASZ87_01394 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) ASZ87_01395 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) ASZ87_01396 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) ASZ87_01397 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) ASZ87_01398 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase ASZ87_01399 ENOG4105K8N protein family UPF0079, ATPase ASZ87_01400 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) ASZ87_01409 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) ASZ87_01410 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) ASZ87_01411 ENOG4105DJ4 phosphatidylserine decarboxylase ASZ87_01412 ENOG4105C8P )-transporter ASZ87_01414 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) ASZ87_01415 ENOG41063SB peptidase ASZ87_01417 ENOG41062JF Transcriptional regulator ASZ87_01418 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) ASZ87_01419 ENOG4105E09 nadh pyrophosphatase ASZ87_01420 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor ASZ87_01421 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ASZ87_01422 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ASZ87_01423 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) ASZ87_01424 ENOG4108VZM 50s ribosomal protein L10 ASZ87_01425 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) ASZ87_01426 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) ASZ87_01427 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) ASZ87_01428 ENOG4105PM1 preprotein translocase subunit SecE ASZ87_01429 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) ASZ87_01434 ENOG4105CS9 pantothenic acid kinase ASZ87_01435 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase ASZ87_01436 ENOG4105D4A Cell wall formation (By similarity) ASZ87_01438 ENOG4105JIM Phosphatidylserine synthase ASZ87_01445 ENOG4107QK7 reductase ASZ87_01447 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) ASZ87_01449 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) ASZ87_01450 ENOG4105K63 Thioredoxin ASZ87_01451 ENOG4105C1J atp-dependent rna helicase ASZ87_01452 ENOG4105C9X ppx gppa phosphatase ASZ87_01453 ENOG4105BZU Histidine kinase ASZ87_01454 ENOG4105D8G Major Facilitator superfamily ASZ87_01470 ENOG4108NYK Tape measure protein ASZ87_01476 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ASZ87_01477 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) ASZ87_01478 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein ASZ87_01479 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase ASZ87_01480 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) ASZ87_01481 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) ASZ87_01482 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) ASZ87_01483 ENOG4105DIQ Transcriptional regulator ASZ87_01484 ENOG4105C01 Dihydroxy-acid dehydratase ASZ87_01485 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family ASZ87_01486 ENOG4105C6Z Gluconate ASZ87_01487 ENOG4108UHU Aldolase ASZ87_01488 ENOG4105E0K tonB-dependent siderophore receptor ASZ87_01491 ENOG4105C8Q Methyl-accepting chemotaxis ASZ87_01492 ENOG4105CXN decarboxylase ASZ87_01493 ENOG4105D5Q Arginine ornithine antiporter ASZ87_01494 ENOG4108M3R transcriptional activator CadC ASZ87_01495 ENOG4105W1Y Transcriptional regulator ASZ87_01496 ENOG4105DC1 bifunctional purine biosynthesis protein purh ASZ87_01497 ENOG4105C12 Phosphoribosylglycinamide synthetase ASZ87_01499 ENOG4105K70 DNA-binding protein ASZ87_01501 ENOG4105DKQ ROK family ASZ87_01502 ENOG4105EIP mannose-6-phosphate isomerase ASZ87_01503 ENOG4105R2J Conserved Protein ASZ87_01504 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase ASZ87_01505 ENOG4108RG0 uracil-dna glycosylase ASZ87_01506 ENOG4105CUY Mechanosensitive ion channel ASZ87_01507 ENOG4105CY0 Metallo-Beta-Lactamase ASZ87_01508 ENOG4105D3Q Sugar transferase ASZ87_01513 ENOG410600T transposase ASZ87_01514 ENOG410600T transposase ASZ87_01515 ENOG4108UT6 Transferase hexapeptide repeat containing protein ASZ87_01517 ENOG4108EKI Dehydrogenase ASZ87_01518 ENOG4105CEY Amp-dependent synthetase and ligase ASZ87_01520 ENOG4105EY8 ABC transporter ASZ87_01523 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase ASZ87_01524 ENOG4105C0K Gdp-mannose 4,6-dehydratase ASZ87_01525 ENOG4107QKV phosphomannomutase ASZ87_01526 ENOG4105CJT Mannose-1-phosphate guanylyltransferase ASZ87_01527 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) ASZ87_01528 ENOG4107T94 Endo-14-beta-xylanase ASZ87_01531 ENOG4105XA0 heptosyltransferase ii ASZ87_01533 ENOG4108ST3 glycosyltransferase ASZ87_01534 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase ASZ87_01540 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) ASZ87_01541 ENOG4105DKP glycosyl transferase, family 9 ASZ87_01542 ENOG4106WTF Glycosyl transferase, family 2 ASZ87_01543 ENOG4105M5K heptosyltransferase ASZ87_01544 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) ASZ87_01545 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) ASZ87_01547 ENOG4105W0E 50S ribosomal protein L33 ASZ87_01548 ENOG4105KDC 50s ribosomal protein l28 ASZ87_01550 ENOG4105C8Q Methyl-accepting chemotaxis ASZ87_01551 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase ASZ87_01552 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) ASZ87_01553 ENOG4105D1S lipid A biosynthesis ASZ87_01554 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase ASZ87_01555 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) ASZ87_01556 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) ASZ87_01557 ENOG4105DSJ YicC domain protein ASZ87_01559 ENOG4105C5Y PTS System ASZ87_01560 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate ASZ87_01561 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) ASZ87_01562 ENOG4105S6R Iron-hydroxamate transporter permease subunit ASZ87_01563 ENOG4105J76 Periplasmic binding protein ASZ87_01564 ENOG4105E0A ABC, transporter ASZ87_01565 ENOG4105E0K tonB-dependent siderophore receptor ASZ87_01566 ENOG4105BZ1 (ABC) transporter ASZ87_01569 ENOG4105C9U ATP-dependent DNA helicase RecQ ASZ87_01570 ENOG4105FR1 rard protein ASZ87_01572 ENOG4108DMH HTH_ARAC ASZ87_01574 ENOG4105C4R Atp-dependent dna helicase ASZ87_01575 ENOG4105DGW oligopeptidase A ASZ87_01576 ENOG4105D6S protein involved in catabolism of external DNA ASZ87_01577 ENOG4105DC8 reductase ASZ87_01584 ENOG4108ZXE ASZ87_01590 ENOG4108UK2 deaminase ASZ87_01592 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ASZ87_01593 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ASZ87_01594 ENOG4105DEF Extracellular solute-binding protein, family 5 ASZ87_01601 ENOG4105MPD Cytochrome ASZ87_01602 ENOG4105C4R Atp-dependent dna helicase ASZ87_01603 ENOG4105Y7M Transcriptional regulator, TetR family ASZ87_01604 ENOG410624X efflux transporter, rnd family, mfp subunit ASZ87_01605 ENOG4105BZS acriflavin resistance protein ASZ87_01606 ENOG4105W0Z cytoplasmic protein ASZ87_01607 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase ASZ87_01608 ENOG4105EMY transcriptional regulator ASZ87_01621 ENOG4108RR8 protoporphyrinogen oxidase ASZ87_01622 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) ASZ87_01623 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein ASZ87_01624 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ASZ87_01625 ENOG4105CHU acetyl-coa acetyltransferase ASZ87_01626 ENOG4105F52 Transcriptional regulator ASZ87_01627 ENOG4105CZQ inner membrane transport protein YdhC ASZ87_01628 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) ASZ87_01629 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) ASZ87_01630 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) ASZ87_01631 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) ASZ87_01632 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) ASZ87_01633 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) ASZ87_01634 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) ASZ87_01635 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) ASZ87_01636 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) ASZ87_01637 ENOG410684E atp synthase ASZ87_01638 ENOG4105FA0 parb-like partition protein ASZ87_01639 ENOG4107QJE Chromosome Partitioning Protein ASZ87_01640 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) ASZ87_01641 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) ASZ87_01642 ENOG4105QTB Flavodoxin ASZ87_01643 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) ASZ87_01644 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins ASZ87_01645 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) ASZ87_01648 ENOG4105E5Q amino acid AbC transporter ASZ87_01649 ENOG4105EAB amino acid AbC transporter ASZ87_01650 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) ASZ87_01651 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) ASZ87_01652 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) ASZ87_01653 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ASZ87_01656 ENOG4108ZNX Heat shock protein ASZ87_01657 ENOG4105JKW Valine--pyruvate aminotransferase ASZ87_01658 ENOG4105C38 Glycyl-tRNA synthetase beta subunit ASZ87_01659 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit ASZ87_01662 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) ASZ87_01664 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family ASZ87_01665 ENOG4105C7B Threonine dehydratase ASZ87_01666 ENOG4105C01 Dihydroxy-acid dehydratase ASZ87_01667 ENOG4105CM2 brancheD-chain amino acid aminotransferase ASZ87_01670 ENOG4105C0P Mg chelatase subunit ChlI ASZ87_01671 ENOG4106HNH Acyl-transferase ASZ87_01672 ENOG4108Z33 Thiol disulfide Interchange Protein ASZ87_01673 ENOG4105E27 serine threonine protein kinase ASZ87_01675 ENOG4105PC1 Conserved Protein ASZ87_01676 ENOG4108N23 SpoOM-related protein ASZ87_01677 ENOG4108UT2 hemolysin iii ASZ87_01679 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) ASZ87_01680 ENOG4105C1A potassium transporter peripheral membrane ASZ87_01681 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B ASZ87_01682 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) ASZ87_01683 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) ASZ87_01684 ENOG4108WZM domain protein ASZ87_01685 ENOG4105C79 DNA protecting protein DprA ASZ87_01686 ENOG4108RPN Protein smg homolog ASZ87_01687 ENOG4108WI1 Dna topoisomerase ASZ87_01688 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit ASZ87_01689 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) ASZ87_01690 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) ASZ87_01691 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) ASZ87_01692 ENOG4105E2X shikimate dehydrogenase ASZ87_01694 ENOG4108Z0R Transferase ASZ87_01701 ENOG4105WMR Protein CrcB homolog ASZ87_01702 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) ASZ87_01704 ENOG4105D06 uba thif-type nad fad binding protein ASZ87_01705 ENOG4105WHD thiamine biosynthesis protein ThiS ASZ87_01706 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) ASZ87_01707 ENOG4105D41 biosynthesis protein thiH ASZ87_01708 ENOG4105DC7 peptidase M24 ASZ87_01708 ENOG4105DC7 peptidase M24 ASZ87_01710 ENOG4105CNH Multidrug resistance protein MdtL ASZ87_01712 ENOG4108VVK transcriptional Regulator, AsnC ASZ87_01713 ENOG4105BZU Histidine kinase ASZ87_01714 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) ASZ87_01716 ENOG4105EMK carboxylate amino acid amine transporter ASZ87_01717 ENOG4108M6U Universal stress protein A ASZ87_01718 ENOG41090A1 ferritin ASZ87_01719 ENOG4108V6B universal stress protein B ASZ87_01720 ENOG4105CBX hi0933 family ASZ87_01722 ENOG4105CGY Dna recombination protein ASZ87_01723 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) ASZ87_01724 ENOG4105JC1 sterol-binding domain protein ASZ87_01725 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) ASZ87_01726 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) ASZ87_01727 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) ASZ87_01728 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) ASZ87_01729 ENOG4105CA0 peroxidase ASZ87_01730 ENOG4107R73 Mate efflux family protein ASZ87_01732 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) ASZ87_01733 ENOG4105E55 glycerol-3-phosphate acyltransferase ASZ87_01734 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) ASZ87_01735 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) ASZ87_01736 ENOG4105X6C Flagellar basal body-associated protein FliL ASZ87_01737 ENOG4105C8Q Methyl-accepting chemotaxis ASZ87_01739 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) ASZ87_01740 ENOG4105F8V Hydrolase, tatD family ASZ87_01741 ENOG4105D52 delta-aminolevulinic acid dehydratase ASZ87_01743 ENOG4105C2M dna polymerase I ASZ87_01744 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) ASZ87_01745 ENOG4106RE7 Cytochrome ASZ87_01747 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) ASZ87_01748 ENOG4105XCT Protein of unknown function (DUF2489) ASZ87_01749 ENOG4105D4P Coproporphyrinogen iii oxidase ASZ87_01750 ENOG410601J HemY protein ASZ87_01751 ENOG4105ECF c-methyltransferase ASZ87_01752 ENOG41076E6 Uroporphyrinogen-III Synthase ASZ87_01753 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) ASZ87_01754 ENOG4107T0K Adenylate cyclase ASZ87_01755 ENOG4105XQ6 frataxin-like protein ASZ87_01756 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) ASZ87_01757 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) ASZ87_01758 ENOG4105CT0 Protein of unknown function, DUF484 ASZ87_01759 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ASZ87_01760 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant ASZ87_01761 ENOG4105BZU Histidine kinase ASZ87_01764 ENOG4105DQF Hydrolase ASZ87_01765 ENOG4108EUD Lysophospholipase ASZ87_01766 ENOG410829K Lysine exporter protein (Lyse ygga) ASZ87_01767 ENOG4105D58 Diguanylate phosphodiesterase ASZ87_01768 ENOG4108RMU ferritin dps family protein ASZ87_01773 ENOG4106H78 methyltransferase ASZ87_01774 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ASZ87_01775 ENOG4105CAK Cell division ATP-binding protein ftsE ASZ87_01776 ENOG4105CRP Part of the ABC transporter FtsEX involved in ASZ87_01777 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ASZ87_01778 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) ASZ87_01781 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) ASZ87_01782 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) ASZ87_01783 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin ASZ87_01784 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) ASZ87_01798 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) ASZ87_01799 ENOG4105BZU Histidine kinase ASZ87_01800 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASZ87_01801 ENOG4105CUX Signal transduction histidine kinase ASZ87_01803 ENOG4105C5F glutamine synthetase ASZ87_01808 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) ASZ87_01809 ENOG4105SUU thioesterase domain ASZ87_01811 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase ASZ87_01812 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) ASZ87_01813 ENOG4105VEJ Heat shock protein ASZ87_01814 ENOG4108XKW General secretion pathway protein C ASZ87_01816 ENOG4107QHF type ii secretion system protein e ASZ87_01817 ENOG4105D7Q type ii secretion system ASZ87_01818 ENOG4108VAU general secretion pathway protein G ASZ87_01819 ENOG4105VWV general secretion pathway protein h ASZ87_01820 ENOG4105X5Z General secretion pathway protein I ASZ87_01821 ENOG4108WWZ General secretion pathway protein J ASZ87_01822 ENOG4108RTD type II secretion system protein K ASZ87_01823 ENOG4108BY5 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) ASZ87_01824 ENOG4105U1E general secretion pathway protein M ASZ87_01825 ENOG4105PIC general secretion pathway protein N ASZ87_01826 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase ASZ87_01827 ENOG4107RK2 ADP-ribose diphosphatase NudE ASZ87_01828 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) ASZ87_01829 ENOG4105MJ2 Competence protein ASZ87_01830 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) ASZ87_01832 ENOG4105BZM domain protein ASZ87_01833 ENOG4108RRZ Transcription elongation factor GreB ASZ87_01834 ENOG4105DPZ Two component transcriptional regulator (Winged helix family ASZ87_01835 ENOG4105E0F Histidine kinase ASZ87_01836 ENOG4105C2W permease ASZ87_01837 ENOG4105CB5 ATP-dependent DNA helicase recG ASZ87_01838 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) ASZ87_01839 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) ASZ87_01840 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) ASZ87_01841 ENOG4105EX9 Membrane ASZ87_01842 ENOG4107QN1 sodium solute ASZ87_01844 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) ASZ87_01846 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) ASZ87_01849 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter ASZ87_01850 ENOG4108IJ0 Aspartate ammonia-lyase ASZ87_01851 ENOG4105BZU Histidine kinase ASZ87_01852 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 ASZ87_01853 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) ASZ87_01855 ENOG4105E0F Histidine kinase ASZ87_01856 ENOG4105E3W Two component transcriptional regulator (Winged helix family ASZ87_01858 ENOG41076HS cation diffusion facilitator family transporter ASZ87_01859 ENOG4105CTQ phosphohexokinase ASZ87_01860 ENOG4105CBT Fructose-1,6-bisphosphatase ASZ87_01861 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) ASZ87_01862 ENOG4105SYT Methylenetetrahydrofolate reductase ASZ87_01863 ENOG4105CFH Aspartokinase ASZ87_01864 ENOG4105C28 cystathionine ASZ87_01865 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) ASZ87_01866 ENOG4105C6K Malic enzyme ASZ87_01867 ENOG4105VFB Binds the 23S rRNA (By similarity) ASZ87_01868 ENOG4105C25 Primosomal protein n' ASZ87_01869 ENOG4105ETE Transcriptional regulator (LacI family ASZ87_01870 ENOG41063M6 Cell Division Protein ASZ87_01871 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) ASZ87_01872 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) ASZ87_01873 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase ASZ87_01874 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) ASZ87_01876 ENOG4105CP7 Triose-phosphate isomerase ASZ87_01881 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) ASZ87_01882 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) ASZ87_01884 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein ASZ87_01885 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) ASZ87_01886 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) ASZ87_01887 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) ASZ87_01888 ENOG4105E33 succinate dehydrogenase ASZ87_01890 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) ASZ87_01891 ENOG4107YZP Rhodanese domain protein ASZ87_01892 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) ASZ87_01893 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase ASZ87_01894 ENOG4105D7W serine acetyltransferase ASZ87_01896 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) ASZ87_01897 ENOG4105CWC Acetylornithine deacetylase ASZ87_01898 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase ASZ87_01899 ENOG4105CAS nag kinase ASZ87_01900 ENOG4105CDH Citrulline--aspartate ligase ASZ87_01901 ENOG4105CH7 arginosuccinase ASZ87_01903 ENOG4107QN2 dihydrolipoyl dehydrogenase ASZ87_01904 ENOG4105EHV domain protein ASZ87_01906 ENOG4108JQC penicillin-binding protein 1A ASZ87_01911 ENOG4105E4G Type IV pilus ASZ87_01912 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) ASZ87_01913 ENOG4105D49 3-dehydroquinate synthase ASZ87_01915 ENOG4105DFE Dna adenine methylase ASZ87_01916 ENOG4105DJV ribulose-phosphate 3-epimerase ASZ87_01917 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) ASZ87_01918 ENOG4105C31 Tryptophanyl-tRNA synthetase ASZ87_01921 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) ASZ87_01922 ENOG4105DDQ anthranilate synthase ASZ87_01923 ENOG4105C8Y Acetylornithine aminotransferase ASZ87_01925 ENOG4105C26 Dehydrogenase ASZ87_01927 ENOG4107RYR Transcriptional regulator, Crp Fnr family ASZ87_01928 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) ASZ87_01930 ENOG4105DNZ Alpha Beta Hydrolase ASZ87_01932 ENOG4105C5H ABC transporter ASZ87_01933 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein ASZ87_01936 ENOG4108YZY peptidylprolyl cis-trans isomerase ASZ87_01937 ENOG4105D44 asparaginase ASZ87_01938 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis ASZ87_01939 ENOG4108UV7 flagellar protein motX ASZ87_01940 ENOG4105E68 Sulfatase ASZ87_01941 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) ASZ87_01942 ENOG4105C2N RNA methyltransferase TrmH family group 3 ASZ87_01943 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) ASZ87_01944 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) ASZ87_01945 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) ASZ87_01946 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) ASZ87_01947 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity ASZ87_01948 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) ASZ87_01949 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) ASZ87_01950 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) ASZ87_01951 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) ASZ87_01952 ENOG41083MP 50s ribosomal protein l29 ASZ87_01953 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal ASZ87_01954 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) ASZ87_01955 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) ASZ87_01956 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits ASZ87_01957 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) ASZ87_01958 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) ASZ87_01959 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) ASZ87_01960 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) ASZ87_01961 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) ASZ87_01962 ENOG4105VPB 50S ribosomal protein L30 ASZ87_01963 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) ASZ87_01964 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) ASZ87_01966 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits ASZ87_01967 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) ASZ87_01968 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) ASZ87_01969 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ASZ87_01970 ENOG4108ZT0 50S ribosomal protein l17 ASZ87_01972 ENOG4108V1T peptidylprolyl cis-trans isomerase ASZ87_01973 ENOG4108UBT opacity-associated protein ASZ87_01974 ENOG4108SXK Transporter Drug Metabolite Exporter family ASZ87_01975 ENOG4107YB6 acetyltransferase, (GNAT) family ASZ87_01976 ENOG4105C1J atp-dependent rna helicase ASZ87_01978 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic ASZ87_01979 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) ASZ87_01980 ENOG4105C11 sulfate adenylyltransferase), subunit 2 ASZ87_01981 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) ASZ87_01982 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) ASZ87_01986 ENOG4105C19 ABC transporter ASZ87_01989 ENOG4108UUE Transcriptional regulator ASZ87_01990 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) ASZ87_01991 ENOG4105CFU surface antigen ASZ87_01993 ENOG41066HZ AIG2-like family ASZ87_01994 ENOG4105F0N pyrophosphate phospho-hydrolase ASZ87_01995 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 ASZ87_01996 ENOG4105DFU Cell wall formation (By similarity) ASZ87_01997 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase ASZ87_01998 ENOG4105DP9 ABC transporter ASZ87_01999 ENOG4106SMU thiamine transporter membrane protein ASZ87_02000 ENOG4107T0D ABC, transporter ASZ87_02001 ENOG4105N42 UPF0307 protein ASZ87_02002 ENOG4105CMS peptidase U62, modulator of DNA gyrase ASZ87_02003 ENOG4105CJW magnesium transporter ASZ87_02004 ENOG41080Z8 PHOSPHOCARRIER protein ASZ87_02005 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) ASZ87_02006 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN ASZ87_02007 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA ASZ87_02008 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ASZ87_02009 ENOG4108IUZ ABC transporter ASZ87_02010 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA ASZ87_02012 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase ASZ87_02013 ENOG4105C2X Arabinose 5-phosphate isomerase ASZ87_02015 ENOG4105DHJ ABC, transporter ASZ87_02016 ENOG4105CY3 ABC transporter, permease ASZ87_02017 ENOG4107PE3 Mammalian cell entry related domain protein ASZ87_02018 ENOG4105E3I toluene tolerance ASZ87_02020 ENOG4105VFK BolA family ASZ87_02021 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) ASZ87_02022 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase ASZ87_02023 ENOG4105KME endoribonuclease L-psp ASZ87_02024 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) ASZ87_02025 ENOG4105CXT aspartate transcarbamylase ASZ87_02026 ENOG4105DBV ornithine carbamoyltransferase ASZ87_02027 ENOG4108IAB Phoh family ASZ87_02028 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) ASZ87_02029 ENOG4105D3G Pseudouridine synthase ASZ87_02030 ENOG4105C5I Dehydrogenase ASZ87_02031 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) ASZ87_02032 ENOG4105MYG DNA polymerase iii, chi subunit ASZ87_02033 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) ASZ87_02034 ENOG4108M8S permease YjgP YjgQ family protein ASZ87_02035 ENOG4108K5H permease YjgP YjgQ family protein ASZ87_02038 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase ASZ87_02047 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) ASZ87_02048 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) ASZ87_02049 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) ASZ87_02050 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) ASZ87_02054 ENOG41064T2 transcriptional regulator, lysR family ASZ87_02055 ENOG4108IQE Amp-dependent synthetase and ligase ASZ87_02056 ENOG4105C7K acetolactate synthase ASZ87_02057 ENOG4108ZP8 Acetolactate synthase small subunit ASZ87_02058 ENOG4108JQ1 Dehydrogenase ASZ87_02059 ENOG4105E66 phosphoriboisomerase A ASZ87_02060 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase ASZ87_02061 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) ASZ87_02063 ENOG4105D0A hydroxylase ASZ87_02064 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family ASZ87_02066 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) ASZ87_02067 ENOG4105Y75 tpr repeat protein ASZ87_02069 ENOG4108IYU L-aspartate oxidase ASZ87_02070 ENOG4105EMN RNA polymerase sigma factor ASZ87_02072 ENOG4105VQK sigma E regulatory protein, MucB RseB ASZ87_02073 ENOG4105WMJ Positive regulator of sigma E, RseC MucC ASZ87_02074 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) ASZ87_02075 ENOG4105C3F Signal peptidase i ASZ87_02076 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) ASZ87_02077 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) ASZ87_02078 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) ASZ87_02079 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) ASZ87_02080 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) ASZ87_02083 ENOG4108K0B C-di-gmp phosphodiesterase ASZ87_02084 ENOG4105BZU Histidine kinase ASZ87_02085 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) ASZ87_02086 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) ASZ87_02087 ENOG4105DXN mazG family ASZ87_02088 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) ASZ87_02089 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) ASZ87_02090 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate ASZ87_02093 ENOG4106MWK domain protein ASZ87_02094 ENOG4105CJ3 phosphate transporter ASZ87_02095 ENOG4107IX6 phosphate transport regulator ASZ87_02096 ENOG4105I7R Adenylate cyclase ASZ87_02098 ENOG4105C8Q Methyl-accepting chemotaxis ASZ87_02099 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) ASZ87_02101 ENOG4105DFG type I secretion outer membrane protein ASZ87_02102 ENOG41087AY ADP-Ribose pyrophosphatase ASZ87_02103 ENOG4108SX3 cytoplasmic protein ASZ87_02104 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) ASZ87_02105 ENOG4105IPS esterase ASZ87_02106 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ASZ87_02107 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ASZ87_02108 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) ASZ87_02109 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) ASZ87_02110 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) ASZ87_02111 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) ASZ87_02112 ENOG4105D7Q type ii secretion system ASZ87_02113 ENOG4107QHF type ii secretion system protein e ASZ87_02115 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase ASZ87_02117 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) ASZ87_02118 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ASZ87_02119 ENOG4105T95 Thiol disulfide interChange protein ASZ87_02120 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) ASZ87_02121 ENOG4105CGH 5'-nucleotidase ASZ87_02122 ENOG41073TP transcriptional regulator ASZ87_02123 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) ASZ87_02124 ENOG4107QSN dihydrolipoamide acetyltransferase ASZ87_02125 ENOG4107QN2 dihydrolipoyl dehydrogenase ASZ87_02126 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) ASZ87_02127 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) ASZ87_02128 ENOG4105CJN penicillin-binding protein ASZ87_02129 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) ASZ87_02130 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) ASZ87_02131 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) ASZ87_02132 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) ASZ87_02134 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) ASZ87_02135 ENOG4105DFU Cell wall formation (By similarity) ASZ87_02136 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) ASZ87_02137 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) ASZ87_02138 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) ASZ87_02139 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) ASZ87_02141 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving ASZ87_02142 ENOG4105M6F mutator MutT protein ASZ87_02143 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) ASZ87_02144 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain ASZ87_02145 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain ASZ87_02150 ENOG4107RRE RNA-directed DNA polymerase ASZ87_02151 ENOG4105EJ9 Membrane ASZ87_02152 ENOG4105VP0 transcriptional regulator, lysR family ASZ87_02153 ENOG4105EN6 Membrane ASZ87_02154 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) ASZ87_02156 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) ASZ87_02158 ENOG4105BZ8 glutamate synthase ASZ87_02159 ENOG4105CBC glutamate synthase ASZ87_02162 ENOG4105N5T Radical SAM Protein ASZ87_02164 ENOG4105BZU Histidine kinase ASZ87_02165 ENOG41065U4 response regulator ASZ87_02167 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) ASZ87_02170 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) ASZ87_02171 ENOG4105D98 threonine synthase ASZ87_02172 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) ASZ87_02173 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) ASZ87_02174 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) ASZ87_02177 ENOG4105BZG amino acid carrier protein ASZ87_02180 ENOG4105EYA deoxyribonuclease ASZ87_02181 ENOG4105D9N nucleoside ASZ87_02182 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) ASZ87_02183 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) ASZ87_02184 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) ASZ87_02185 ENOG4105D3A purine nucleoside phosphorylase DeoD-type ASZ87_02187 ENOG4105EAC phosphoserine phosphatase ASZ87_02189 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) ASZ87_02190 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) ASZ87_02191 ENOG4108IQE Amp-dependent synthetase and ligase ASZ87_02192 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase ASZ87_02194 ENOG4105CNT hydrolase family 2 ASZ87_02195 ENOG41060NJ transcriptional regulator ASZ87_02196 ENOG4108Y51 tRNA-binding protein ASZ87_02199 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) ASZ87_02201 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) ASZ87_02203 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) ASZ87_02204 ENOG4105X2V dna damage-inducible protein ASZ87_02207 ENOG4105DSY exodeoxyribonuclease V, gamma ASZ87_02208 ENOG4107QKA exodeoxyribonuclease V beta ASZ87_02209 ENOG4107QYX exodeoxyribonuclease v alpha ASZ87_02211 ENOG4107QZM n-acetylglutamate synthase ASZ87_02213 ENOG4105CA3 membrane-bound lytic murein transglycosylase ASZ87_02214 ENOG4105CUZ uba thif-type nad fad binding protein ASZ87_02215 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) ASZ87_02216 ENOG4105C9B Cysteine desulfurase ASZ87_02217 ENOG4107S0N DJ-1 family ASZ87_02218 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) ASZ87_02219 ENOG4105DRB nucleoside-specific channel-forming protein ASZ87_02221 ENOG4105K6V RNA polymerase ASZ87_02223 ENOG4105EYM Major Facilitator superfamily ASZ87_02224 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) ASZ87_02226 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) ASZ87_02227 ENOG4105M85 Bola protein ASZ87_02228 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ASZ87_02229 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ASZ87_02230 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ASZ87_02231 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ASZ87_02232 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ASZ87_02233 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) ASZ87_02234 ENOG4105CJ2 (LipO)protein ASZ87_02236 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) ASZ87_02238 ENOG4105BZU Histidine kinase ASZ87_02239 ENOG4105C8J )-transporter ASZ87_02241 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) ASZ87_02242 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) ASZ87_02243 ENOG4105CIN aminoacyl-histidine dipeptidase ASZ87_02244 ENOG4105C7N Xanthine uracil vitamin C permease ASZ87_02245 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) ASZ87_02247 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) ASZ87_02248 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) ASZ87_02249 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) ASZ87_02250 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) ASZ87_02251 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) ASZ87_02254 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) ASZ87_02255 ENOG4107YIM Involved in the transcription termination process (By similarity) ASZ87_02256 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) ASZ87_02257 ENOG4108ZAI phosphatidylglycerophosphatase a ASZ87_02258 ENOG4108T8E UPF0325 protein ASZ87_02259 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) ASZ87_02260 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) ASZ87_02261 ENOG4105CE9 30S ribosomal protein S2 ASZ87_02262 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) ASZ87_02263 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) ASZ87_02264 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) ASZ87_02265 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) ASZ87_02266 ENOG4105KNE Phosphatidate cytidylyltransferase ASZ87_02267 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) ASZ87_02268 ENOG4105DZP Membrane-associated zinc metalloprotease ASZ87_02270 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) ASZ87_02271 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) ASZ87_02272 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) ASZ87_02273 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) ASZ87_02274 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) ASZ87_02275 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) ASZ87_02276 ENOG4105C0B DNA polymerase III (alpha subunit) ASZ87_02277 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) ASZ87_02278 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) ASZ87_02279 ENOG4105N7H Cytochrome ASZ87_02280 ENOG4105PY6 Phenolic acid decarboxylase ASZ87_02281 ENOG4108YZA Nitrogen regulatory protein pii ASZ87_02283 ENOG4105E9H Lytic Murein transglycosylase ASZ87_02284 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) ASZ87_02285 ENOG4105D1A Methyltransferase ASZ87_02286 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) ASZ87_02287 ENOG4108JDX DNA polymerase iii, epsilon subunit ASZ87_02289 ENOG4107QPN acyl-Coa dehydrogenase ASZ87_02290 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) ASZ87_02291 ENOG4105E7A Glutamine amidotransferase ASZ87_02292 ENOG4108V3E phosphoribosylglycinamide formyltransferase ASZ87_02293 ENOG4105CXB phosphoribosylaminoimidazole synthetase ASZ87_02294 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) ASZ87_02295 ENOG4105BZU Histidine kinase ASZ87_02296 ENOG4105FE9 pseudouridine synthase ASZ87_02297 ENOG4108DG9 Smr protein MutS2 ASZ87_02300 ENOG4105MBR gumn family ASZ87_02301 ENOG4105E2D ec 3.2.1.52 ASZ87_02303 ENOG4105C59 p-type ATPase ASZ87_02304 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) ASZ87_02305 ENOG4105UYK outer membrane protein a ASZ87_02307 ENOG4107RBR Receptor ASZ87_02308 ENOG4105Q26 Siderophore-interacting protein ASZ87_02309 ENOG4105C0W non-ribosomal peptide synthetase ASZ87_02316 ENOG4107R88 Chemotaxis protein (CheV) ASZ87_02317 ENOG4105BZU Histidine kinase ASZ87_02318 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) ASZ87_02319 ENOG4108ZC9 flagellar basal-body rod protein flgc ASZ87_02320 ENOG4105W00 Flagellar hook capping protein ASZ87_02321 ENOG4105BZE flagellar hook protein, FlgE ASZ87_02322 ENOG4108KPB Flagellar basal-body rod protein FlgF ASZ87_02323 ENOG4105CGA flagellar basal-body rod protein FlgG ASZ87_02324 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) ASZ87_02325 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) ASZ87_02326 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj ASZ87_02329 ENOG4105I03 Flagellin ASZ87_02330 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ASZ87_02334 ENOG4105MEH ASZ87_02350 ENOG4105ED4 portal protein ASZ87_02375 ENOG4105I03 Flagellin ASZ87_02392 ENOG4105C3G gtp-binding protein ASZ87_02393 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) ASZ87_02394 ENOG4105C5T Phosphoribosyl pyrophosphate synthase ASZ87_02395 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) ASZ87_02396 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) ASZ87_02397 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) ASZ87_02398 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) ASZ87_02399 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) ASZ87_02400 ENOG4108YY7 Invasion gene expression up-regulator SirB ASZ87_02401 ENOG41063JG Transcriptional regulator ASZ87_02402 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase ASZ87_02403 ENOG4105CGH 5'-nucleotidase ASZ87_02404 ENOG4108Z66 YbaK ebsC protein ASZ87_02405 ENOG4105C2W permease ASZ87_02408 ENOG4105CS1 NAD(P)H quinone oxidoreductase ASZ87_02409 ENOG4105K89 arsenate reductase ASZ87_02410 ENOG4105ERG peptidase m48, ste24p ASZ87_02413 ENOG4105C8Q Methyl-accepting chemotaxis ASZ87_02414 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen ASZ87_02416 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ASZ87_02417 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) ASZ87_02420 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) ASZ87_02421 ENOG4105KUZ arsenate reductase ASZ87_02424 ENOG4105QZU Inner membrane protein YfeZ ASZ87_02425 ENOG4105EZR dyp-type peroxidase family protein ASZ87_02426 ENOG4105I03 Flagellin ASZ87_02427 ENOG4105I03 Flagellin ASZ87_02428 ENOG4105I03 Flagellin ASZ87_02429 ENOG41063QE flagellar protein FlaG ASZ87_02430 ENOG4107W9T flagellar hook-associated ASZ87_02432 ENOG4105MQ3 flagellar protein FliS ASZ87_02433 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASZ87_02434 ENOG4105BZU Histidine kinase ASZ87_02435 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASZ87_02436 ENOG4105VQ0 flagellar hook-basal body complex protein fliE ASZ87_02437 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) ASZ87_02438 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) ASZ87_02439 ENOG4105W2B Flagellar assembly protein ASZ87_02440 ENOG4108JIR Flagellum-specific ATP synthase ASZ87_02443 ENOG4105X6C Flagellar basal body-associated protein FliL ASZ87_02444 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) ASZ87_02445 ENOG4105DD5 Flagellar motor switch protein ASZ87_02446 ENOG4105VTB flagellar biosynthesis protein fliO ASZ87_02447 ENOG4105CN7 Flagellar biosynthetic protein FliP ASZ87_02448 ENOG4105VS8 Flagellar biosynthetic protein fliq ASZ87_02449 ENOG4105D19 Role in flagellar biosynthesis (By similarity) ASZ87_02450 ENOG4105D00 flagellar biosynthetic protein flhB ASZ87_02452 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) ASZ87_02453 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase ASZ87_02454 ENOG4105EN6 Membrane ASZ87_02455 ENOG4108BPE -transporting atpase ASZ87_02456 ENOG4105MH2 YfcL protein ASZ87_02457 ENOG4105Q8W reductase ASZ87_02458 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) ASZ87_02459 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) ASZ87_02460 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) ASZ87_02461 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) ASZ87_02462 ENOG41090R7 Ferric uptake ASZ87_02464 ENOG4105CMU LysR family (Transcriptional regulator ASZ87_02465 ENOG4105VAW lrga family ASZ87_02466 ENOG41067MG lrgb family ASZ87_02467 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) ASZ87_02469 ENOG4105EV9 Alpha Beta Hydrolase ASZ87_02470 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) ASZ87_02471 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 ASZ87_02473 ENOG4107QNR UPF0135 protein ASZ87_02474 ENOG4105BZN citrate synthase ASZ87_02475 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit ASZ87_02476 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein ASZ87_02477 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) ASZ87_02478 ENOG4105E33 succinate dehydrogenase ASZ87_02479 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 ASZ87_02480 ENOG4105C7S Dehydrogenase ASZ87_02481 ENOG4105CMV Succinyl-CoA synthetase subunit beta ASZ87_02482 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha ASZ87_02483 ENOG4105FAV ABC, transporter ASZ87_02484 ENOG4105FDK ABC transporter ASZ87_02485 ENOG4105NXV High-affinity zinc uptake system protein ASZ87_02486 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) ASZ87_02487 ENOG4105XFK Ferrous iron transport protein A ASZ87_02491 ENOG4105C75 arginyL-tRNA synthetase ASZ87_02493 ENOG4108JQM Insulinase (Peptidase family M16) ASZ87_02494 ENOG4108BY2 phosphohistidine phosphatase ASZ87_02495 ENOG4105D7B Flagellar biosynthesis protein flha ASZ87_02496 ENOG4105FZW flagellar biosynthesis regulator FlhF ASZ87_02497 ENOG4107R21 site-determining protein ASZ87_02498 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ASZ87_02499 ENOG4108VYJ response regulator receiver protein ASZ87_02500 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) ASZ87_02501 ENOG4105CBS Chea signal transduction histidine kinase ASZ87_02502 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) ASZ87_02503 ENOG4107QJE Chromosome Partitioning Protein ASZ87_02505 ENOG4108V3W Chemotaxis protein, CheW ASZ87_02507 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) ASZ87_02508 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) ASZ87_02509 ENOG41060IM Heme exporter protein ASZ87_02510 ENOG41067VX Heme exporter protein ASZ87_02511 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) ASZ87_02512 ENOG4105DA4 cytochrome c-type biogenesis protein ASZ87_02513 ENOG4107QX9 Thiol disulfide interChange protein ASZ87_02514 ENOG4105KWW Biogenesis protein ASZ87_02516 ENOG410903C (LipO)protein ASZ87_02519 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ASZ87_02520 ENOG4105M2J Glutaredoxin ASZ87_02521 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) ASZ87_02522 ENOG4105DGU Histone deacetylase ASZ87_02525 ENOG4105E68 Sulfatase ASZ87_02527 ENOG4106V8H Nucleoid-associated protein ASZ87_02529 ENOG4105DFD Na H antiporter ASZ87_02530 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) ASZ87_02531 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein ASZ87_02532 ENOG4108EKI Dehydrogenase ASZ87_02534 ENOG4105CHH sulfate transporter ASZ87_02535 ENOG4105C03 ribonuclease ASZ87_02536 ENOG4105EI2 Pseudouridine synthase ASZ87_02537 ENOG4108UHJ MAF-like protein ASZ87_02538 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein ASZ87_02539 ENOG4105VGS 50s ribosomal protein l32 ASZ87_02540 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) ASZ87_02541 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) ASZ87_02542 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase ASZ87_02543 ENOG4105CHR reductase ASZ87_02544 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) ASZ87_02545 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) ASZ87_02546 ENOG4105YAZ 4-amino-4-deoxychorismate lyase ASZ87_02547 ENOG4105HHA aminodeoxychorismate lyase ASZ87_02548 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) ASZ87_02549 ENOG4107QRG dna polymerase iii ASZ87_02550 ENOG4105F8V Hydrolase, tatD family ASZ87_02551 ENOG4105CI1 PTS System ASZ87_02553 ENOG4105C8J )-transporter ASZ87_02556 ENOG4108NRW Phospholipase, patatin family ASZ87_02557 ENOG4105CA9 Pyruvate kinase ASZ87_02558 ENOG4105DAG ROK family ASZ87_02559 ENOG4107R88 Chemotaxis protein (CheV) ASZ87_02562 ENOG4105DHI Methyltransferase ASZ87_02564 ENOG4105DSB aldose 1-epimerase ASZ87_02565 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase ASZ87_02566 ENOG4105E0X reductase ASZ87_02568 ENOG4105VUT cytoplasmic protein ASZ87_02569 ENOG4105HDK L-asparaginase ASZ87_02570 ENOG4105D07 Signal peptide peptidase, SppA ASZ87_02571 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ASZ87_02572 ENOG4105CIY formyltetrahydrofolate deformylase ASZ87_02574 ENOG4105DVT helicase ASZ87_02575 ENOG41072GX Peptidase M22 Glycoprotease ASZ87_02578 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) ASZ87_02579 ENOG4105CEY Amp-dependent synthetase and ligase ASZ87_02580 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) ASZ87_02584 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein ASZ87_02585 ENOG4105DK2 UPF0207 protein ASZ87_02586 ENOG4105CHM Aminotransferase ASZ87_02587 ENOG4105E4F Isochorismate synthase ASZ87_02588 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) ASZ87_02589 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) ASZ87_02590 ENOG4108IPT Naphthoate synthase ASZ87_02591 ENOG4105DNI Converts SHCHC to OSB (By similarity) ASZ87_02592 ENOG4105CEY Amp-dependent synthetase and ligase ASZ87_02593 ENOG4105DKK Benzoate ASZ87_02594 ENOG4108JCI Transcriptional regulator ASZ87_02595 ENOG4108N3W hemolysin secretion protein ASZ87_02596 ENOG4107S74 Lysophospholipid transporter LplT ASZ87_02602 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) ASZ87_02603 ENOG4107QMS site-determining protein ASZ87_02604 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) ASZ87_02605 ENOG4105VNG YcgL domain-containing protein ASZ87_02606 ENOG4105CVE Lytic murein transglycosylase ASZ87_02607 ENOG4105JQN Transcriptional regulator ASZ87_02608 ENOG4105D9N nucleoside ASZ87_02609 ENOG410662T chitinase ASZ87_02610 ENOG4105CUW cytochrome C-TYPE protein ASZ87_02611 ENOG4107QY8 reductase ASZ87_02613 ENOG4105JQN Transcriptional regulator ASZ87_02617 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) ASZ87_02624 ENOG4108HPI phosphatidate Cytidylyltransferase ASZ87_02626 ENOG4105BZU Histidine kinase ASZ87_02629 ENOG4105CNG UPF0061 protein ASZ87_02630 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit ASZ87_02631 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ ASZ87_02632 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ASZ87_02633 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASZ87_02635 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation ASZ87_02636 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) ASZ87_02637 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) ASZ87_02638 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) ASZ87_02639 ENOG4105K70 DNA-binding protein ASZ87_02640 ENOG4105EIN peptidylprolyl cis-trans isomerase ASZ87_02641 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein ASZ87_02642 ENOG4105CAT Cytidine monophosphate kinase ASZ87_02643 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) ASZ87_02644 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) ASZ87_02645 ENOG4105Q4A inner membrane protein yciS ASZ87_02646 ENOG4105CFV Tetratricopeptide repeat protein ASZ87_02647 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) ASZ87_02648 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase ASZ87_02650 ENOG4107R11 Transcriptional regulator ASZ87_02652 ENOG4105DCF alanine dehydrogenase ASZ87_02653 ENOG4105EW9 transcriptional regulator AsnC family ASZ87_02654 ENOG4105CNU cell division protein FtsK ASZ87_02655 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) ASZ87_02656 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) ASZ87_02657 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) ASZ87_02659 ENOG4108NVR Methyl-accepting chemotaxis ASZ87_02660 ENOG4105K59 histidine triad (HIT) protein ASZ87_02666 ENOG4105CEP NADH dehydrogenase ASZ87_02668 ENOG4106M3D hemolysin ASZ87_02670 ENOG4108JA2 transcriptioN-repair coupling factor ASZ87_02672 ENOG4105D60 lipoprotein releasing system transmembrane protein ASZ87_02673 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) ASZ87_02674 ENOG4105D60 lipoprotein releasing system transmembrane protein ASZ87_02676 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 ASZ87_02677 ENOG4105BZ1 (ABC) transporter ASZ87_02678 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) ASZ87_02680 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) ASZ87_02681 ENOG4105ED1 spovr family ASZ87_02682 ENOG4106AKX UPF0229 protein ASZ87_02683 ENOG4105CYN Serine protein kinase ASZ87_02684 ENOG4105XWI UPF0304 protein ASZ87_02686 ENOG4105F1A Pyruvate formate-lyase ASZ87_02687 ENOG4108N3W hemolysin secretion protein ASZ87_02689 ENOG4105C6N Formate acetyltransferase ASZ87_02692 ENOG4108JEH abc transporter atp-binding protein ASZ87_02693 ENOG4105E89 ABC transporter ASZ87_02694 ENOG4105DSP amino acid AbC transporter ASZ87_02695 ENOG4106YG3 ABC transporter ASZ87_02696 ENOG4105CGK Exodeoxyribonuclease III ASZ87_02697 ENOG4105C8Q Methyl-accepting chemotaxis ASZ87_02698 ENOG4106428 Protein of unknown function (DUF2496) ASZ87_02699 ENOG4108URS primosomal replication protein n'' ASZ87_02700 ENOG4105EJ9 Membrane ASZ87_02701 ENOG4105DVT helicase ASZ87_02702 ENOG4105ZU8 porin-like protein H ASZ87_02705 ENOG4105D58 Diguanylate phosphodiesterase ASZ87_02706 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) ASZ87_02707 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) ASZ87_02708 ENOG4105C8N cysteinyl-tRNA synthetase ASZ87_02709 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) ASZ87_02710 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) ASZ87_02711 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) ASZ87_02713 ENOG4105C4M (Ubiquinol oxidase) subunit I ASZ87_02714 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ASZ87_02716 ENOG4107YD3 Thioesterase ASZ87_02717 ENOG4105E02 MotA TolQ exbB proton channel ASZ87_02718 ENOG4105M8F Biopolymer transport protein exbD tolR ASZ87_02720 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) ASZ87_02721 ENOG4105KCK Peptidoglycan-associated lipoprotein ASZ87_02723 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) ASZ87_02725 ENOG4105BZU Histidine kinase ASZ87_02726 ENOG4108RNS Exports L-alanine (By similarity) ASZ87_02727 ENOG4105EIP mannose-6-phosphate isomerase ASZ87_02728 ENOG4105DM4 PTS System ASZ87_02729 ENOG4106R3P AraC family transcriptional regulator ASZ87_02731 ENOG4108YRF PTS System ASZ87_02732 ENOG4105DM4 PTS System ASZ87_02733 ENOG4105DM4 PTS System ASZ87_02735 ENOG4105C26 Dehydrogenase ASZ87_02736 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family ASZ87_02737 ENOG4105VYA Uncharacterized conserved protein (DUF2132) ASZ87_02739 ENOG4105CVP deoxyribo-dipyrimidine photolyase ASZ87_02771 ENOG4107U4H Methyl-accepting chemotaxis ASZ87_02773 ENOG4105UQX Mate efflux family protein ASZ87_02774 ENOG4105C1J atp-dependent rna helicase ASZ87_02775 ENOG4105CR8 Transcriptional regulator ASZ87_02777 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ASZ87_02779 ENOG4105BZ1 (ABC) transporter ASZ87_02781 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ASZ87_02788 ENOG4105K56 Transcriptional regulator ASZ87_02789 ENOG4108ZHJ Organic hydroperoxide resistance protein ASZ87_02791 ENOG4108SXK Transporter Drug Metabolite Exporter family ASZ87_02792 ENOG4105VW4 glutaredoxin 3 ASZ87_02793 ENOG4108P2H Inner membrane protein YjiG ASZ87_02794 ENOG41074DU domain protein ASZ87_02795 ENOG4105DN9 Na H antiporter ASZ87_02797 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) ASZ87_02798 ENOG4105D03 DNA-3-methyladenine glycosylase II ASZ87_02799 ENOG4108VGI doxx family ASZ87_02804 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) ASZ87_02806 ENOG4107W52 maltose operon periplasmic protein ASZ87_02807 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) ASZ87_02810 ENOG4108N3W hemolysin secretion protein ASZ87_02813 ENOG4105C8Q Methyl-accepting chemotaxis ASZ87_02815 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) ASZ87_02816 ENOG4105CDA abc transporter atp-binding protein ASZ87_02818 ENOG4106TNF Periplasmic binding protein ASZ87_02819 ENOG4105EZ7 amino acid ABC transporter ASZ87_02820 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain ASZ87_02821 ENOG4105DR5 peptidase ASZ87_02823 ENOG4105CTS PTS system mannitol-specific ASZ87_02824 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase ASZ87_02825 ENOG4105E61 Mannitol repressor protein ASZ87_02826 ENOG4105EP9 oxidoreductase ASZ87_02832 ENOG4108RYK Nad-dependent epimerase dehydratase ASZ87_02833 ENOG4105JQN Transcriptional regulator ASZ87_02834 ENOG41069D7 Methyl-accepting chemotaxis ASZ87_02835 ENOG4105EMU Dehydrogenase ASZ87_02836 ENOG4105JQN Transcriptional regulator ASZ87_02838 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) ASZ87_02839 ENOG4105D5Q Arginine ornithine antiporter ASZ87_02840 ENOG4105CXN decarboxylase ASZ87_02841 ENOG4107RGH Aldehyde dehydrogenase ASZ87_02842 ENOG4105EW9 transcriptional regulator AsnC family ASZ87_02843 ENOG4105C8Q Methyl-accepting chemotaxis ASZ87_02845 ENOG4105CK7 Sodium proline symporter ASZ87_02847 ENOG4105C26 Dehydrogenase ASZ87_02850 ENOG4105E6M Sulphatase-modifying factor protein ASZ87_02852 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) ASZ87_02853 ENOG4107QZV Type I secretion membrane fusion protein ASZ87_02856 ENOG4108JJA ABC, transporter ASZ87_02858 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ASZ87_02860 ENOG4105C8Q Methyl-accepting chemotaxis ASZ87_02861 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) ASZ87_02862 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) ASZ87_02863 ENOG4105BZU Histidine kinase ASZ87_02864 ENOG4105C8Q Methyl-accepting chemotaxis ASZ87_02865 ENOG4108V3W Chemotaxis protein, CheW ASZ87_02866 ENOG4108V3W Chemotaxis protein, CheW ASZ87_02867 ENOG4105CBS Chea signal transduction histidine kinase ASZ87_02868 ENOG4108VYJ response regulator receiver protein ASZ87_02871 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ASZ87_02872 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ASZ87_02873 ENOG4108JQ6 ABC transporter ASZ87_02874 ENOG4105DIJ Phosphoethanolamine transferase ASZ87_02875 ENOG4105DHQ Histidine kinase ASZ87_02876 ENOG4105XJC Two component transcriptional regulator (Winged helix family ASZ87_02882 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) ASZ87_02883 ENOG4107RUE extracellular solute-binding protein family 1 ASZ87_02884 ENOG4106RMF ParB family ASZ87_02890 ENOG4105CDY transcriptional regulatory protein ASZ87_02891 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase ASZ87_02892 ENOG4105C8Q Methyl-accepting chemotaxis ASZ87_02893 ENOG4108YYI Protein of unknown function (DUF2810) ASZ87_02894 ENOG41061ZR Transcriptional regulator ASZ87_02895 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) ASZ87_02896 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) ASZ87_02897 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) ASZ87_02898 ENOG4108WC9 type VI secretion system effector, hcp1 family ASZ87_02899 ENOG4105CS6 Rhs element vgr protein ASZ87_02904 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ASZ87_02906 ENOG4105C8P )-transporter ASZ87_02907 ENOG4108Q67 UPF0319 protein ASZ87_02912 ENOG4105C8Q Methyl-accepting chemotaxis ASZ87_02916 ENOG4105EYK Phosphatidylglycerophosphatase B ASZ87_02917 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) ASZ87_02922 ENOG4105D6U Sodium Glutamate Symporter ASZ87_02923 ENOG4105YE1 PilZ domain ASZ87_02926 ENOG4105EFX secretion protein, HlyD family ASZ87_02927 ENOG4105KK7 inner membrane protein YiaW ASZ87_02928 ENOG4106TD9 Diguanylate cyclase ASZ87_02931 ENOG4105D3A purine nucleoside phosphorylase DeoD-type ASZ87_02932 ENOG4107SEY Conserved Protein ASZ87_02934 ENOG4105CVP deoxyribo-dipyrimidine photolyase ASZ87_02935 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein ASZ87_02937 ENOG4105C1J atp-dependent rna helicase ASZ87_02938 ENOG4105CUG Oligopeptidase b ASZ87_02944 ENOG4105CVA phosphate ASZ87_02945 ENOG4105C8U phosphate abc transporter ASZ87_02946 ENOG4105E2Z phosphate ABC transporter (Permease ASZ87_02947 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) ASZ87_02950 ENOG4105DWD nucleoside recognition domain protein ASZ87_02951 ENOG4105CHH sulfate transporter ASZ87_02953 ENOG4105DR5 peptidase ASZ87_02954 ENOG4105BZU Histidine kinase ASZ87_02956 ENOG4105EQ2 LysR family Transcriptional regulator ASZ87_02957 ENOG4105E5M Multidrug resistance protein D ASZ87_02958 ENOG4108Z4X TRANSCRIPTIONal ASZ87_02962 ENOG4105CK2 sodium dicarboxylate symporter ASZ87_02970 ENOG4107RH7 Nicotinate phosphoribosyltransferase ASZ87_02971 ENOG4105D9R oxidoreductase ASZ87_02973 ENOG4105BZU Histidine kinase ASZ87_02974 ENOG4107VXZ Hydrolase ASZ87_02976 ENOG4105D3G Pseudouridine synthase ASZ87_02988 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ASZ87_02989 ENOG4108JUB Transcriptional regulator ASZ87_02994 ENOG4105CS6 Rhs element vgr protein ASZ87_02997 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) ASZ87_02998 ENOG4105C2J ABC transporter ASZ87_02999 ENOG4105CNN ABC, transporter ASZ87_03000 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator ASZ87_03001 ENOG4108RVA ribokinase ASZ87_03002 ENOG4105ETE Transcriptional regulator (LacI family ASZ87_03004 ENOG4106Z1T Nicotinamide Mononucleotide Transporter ASZ87_03005 ENOG4108I5U Uridine phosphorylase ASZ87_03007 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase ASZ87_03008 ENOG4105CXY transporter ASZ87_03011 ENOG4105CQZ Histidine kinase ASZ87_03012 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASZ87_03015 ENOG4105D5U fad dependent oxidoreductase ASZ87_03017 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) ASZ87_03019 ENOG4105KJM monovalent cation h antiporter subunit g ASZ87_03020 ENOG41080TA Multiple resistance and ph regulation protein f ASZ87_03021 ENOG4105SC1 monovalent cation H antiporter subunit E ASZ87_03022 ENOG4108JPZ Monovalent cation H antiporter subunit D ASZ87_03023 ENOG4105MKQ Monovalent cation H antiporter subunit C ASZ87_03024 ENOG4105D65 subunit l ASZ87_03026 ENOG4105Q9Y Universal stress protein ASZ87_03027 ENOG4105CIC tryptophan-specific transport protein ASZ87_03028 ENOG4105C0F tryptophanase EC 4.1.99.1 ASZ87_03030 ENOG4105VRT cytoplasmic protein ASZ87_03032 ENOG4105BZU Histidine kinase ASZ87_03033 ENOG4105VEQ Cold shock protein ASZ87_03040 ENOG4105C7R Atpase associated with various cellular activities aaa_3 ASZ87_03041 ENOG41069D7 Methyl-accepting chemotaxis ASZ87_03044 ENOG4105D9N nucleoside ASZ87_03045 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) ASZ87_03047 ENOG4108JUA Transcriptional regulator ASZ87_03048 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) ASZ87_03049 ENOG4105VEQ Cold shock protein ASZ87_03054 ENOG4108UNF response regulator ASZ87_03056 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) ASZ87_03057 ENOG4105C5I Dehydrogenase ASZ87_03061 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) ASZ87_03066 ENOG4108RS6 transposase ASZ87_03067 ENOG4105C1J atp-dependent rna helicase ASZ87_03068 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter ASZ87_03069 ENOG4107RA1 nh(3)-dependent nad( ) synthetase ASZ87_03070 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) ASZ87_03072 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase ASZ87_03073 ENOG4105BZU Histidine kinase ASZ87_03075 ENOG4107S6Z Na H antiporter ASZ87_03076 ENOG4105E5M Multidrug resistance protein D ASZ87_03077 ENOG4105BZU Histidine kinase ASZ87_03078 ENOG4105KUU lipolytic protein G-D-S-L family ASZ87_03079 ENOG4106M3D hemolysin ASZ87_03080 ENOG4108N3W hemolysin secretion protein ASZ87_03081 ENOG4107IFA Lipase (EC 3.1.1.3) ASZ87_03083 ENOG4107G87 m6 family metalloprotease domain protein ASZ87_03087 ENOG4105DHS permease protein ASZ87_03088 ENOG4105CM4 permease protein ASZ87_03089 ENOG4108IPW abc transporter atp-binding protein ASZ87_03093 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) ASZ87_03097 ENOG4105ETX regulatoR ASZ87_03099 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase ASZ87_03101 ENOG410667J hydrolase ASZ87_03107 ENOG4105DS1 cytochrome b561 ASZ87_03113 ENOG4105XJC Two component transcriptional regulator (Winged helix family ASZ87_03114 ENOG4105BZU Histidine kinase ASZ87_03119 ENOG4107QVI Methyltransferase, type 11 ASZ87_03122 ENOG4105C2C drug resistance transporter, Bcr CflA ASZ87_03123 ENOG4105C8Q Methyl-accepting chemotaxis ASZ87_03125 ENOG4105DZ1 carboxypeptidase ASZ87_03130 ENOG4108RS6 transposase ASZ87_03131 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor ASZ87_03132 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) ASZ87_03133 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) ASZ87_03135 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) ASZ87_03137 ENOG4105F2I Transposase ASZ87_03142 ENOG4105C22 threonyL-tRNA synthetase ASZ87_03143 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) ASZ87_03144 ENOG41082NX 50s ribosomal protein l35 ASZ87_03145 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) ASZ87_03152 ENOG4105CYX Short-chain dehydrogenase reductase Sdr ASZ87_03153 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase ASZ87_03181 ENOG4105EST Metal Dependent Phosphohydrolase ASZ87_03193 ENOG4105CYX Short-chain dehydrogenase reductase Sdr ASZ87_03196 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein ASZ87_03203 ENOG4105D9U N-acetyltransferase ASZ87_03204 ENOG4105QNF Outer membrane lipoprotein ASZ87_03208 ENOG4105VXN addiction module toxin, RelE StbE family ASZ87_03210 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase ASZ87_03220 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A ASZ87_03223 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase ASZ87_03231 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase ASZ87_03234 ENOG4105QNF Outer membrane lipoprotein ASZ87_03236 ENOG4105YGK Pfam:UPF0157 ASZ87_03237 ENOG4105N14 lysine exporter protein LysE YggA ASZ87_03266 ENOG41080ET plasmid maintenance system killer protein ASZ87_03267 ENOG4105VDM plasmid maintenance system antidote protein, xre family ASZ87_03268 ENOG4108S58 Phenazine biosynthesis protein PhzF ASZ87_03274 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase ASZ87_03277 ENOG4105QNF Outer membrane lipoprotein ASZ87_03282 ENOG4105D9U N-acetyltransferase ASZ87_03298 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A ASZ87_03302 ENOG4105QNF Outer membrane lipoprotein ASZ87_03313 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein ASZ87_03314 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein ASZ87_03321 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase ASZ87_03328 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system ASZ87_03329 ENOG4105W08 virulence gene repressor rsal ASZ87_03332 ENOG4105F2I Transposase ASZ87_03333 ENOG4105EQK -acetyltransferase ASZ87_03336 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase ASZ87_03352 ENOG4108RS6 transposase ASZ87_03362 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase ASZ87_03367 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase ASZ87_03368 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) ASZ87_03369 ENOG4105CGF Aromatic amino acid aminotransferase ASZ87_03370 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) ASZ87_03371 ENOG4105DM4 PTS System ASZ87_03372 ENOG4105DE4 1-phosphofructokinase ASZ87_03373 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein ASZ87_03374 ENOG4107B7Y DNA-binding transcriptional regulator FruR ASZ87_03375 ENOG4107RFY SbcCD D subunit ASZ87_03376 ENOG4105EYH Exonuclease ASZ87_03377 ENOG4108MGY Histidine kinase ASZ87_03378 ENOG4107KBT 8-Amino-7-oxononanoate synthase ASZ87_03380 ENOG4105CMQ Chloride channel ASZ87_03381 ENOG4105CKI cobalamin synthesis protein ASZ87_03382 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) ASZ87_03383 ENOG4105DFH Transport of potassium into the cell (By similarity) ASZ87_03384 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) ASZ87_03385 ENOG4105C08 Histidine kinase ASZ87_03386 ENOG4105EEX Two component transcriptional regulator (Winged helix family ASZ87_03387 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) ASZ87_03388 ENOG4108RHM integral membrane protein ASZ87_03390 ENOG4105EPM Diguanylate phosphodiesterase ASZ87_03392 ENOG4105DS1 cytochrome b561 ASZ87_03394 ENOG4105TMB Formate nitrite transporter ASZ87_03395 ENOG4105DUM transcriptional regulator, lysR family ASZ87_03396 ENOG4108UQ5 membrane protein YcdZ ASZ87_03397 ENOG4105CPB ATP-dependent endonuclease of the OLD family ASZ87_03398 ENOG4105CGH 5'-nucleotidase ASZ87_03400 ENOG4105DU1 integral membrane protein, terc ASZ87_03402 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA ASZ87_03408 ENOG4105BZU Histidine kinase ASZ87_03410 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) ASZ87_03412 ENOG4105BZU Histidine kinase ASZ87_03415 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) ASZ87_03416 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) ASZ87_03418 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ASZ87_03422 ENOG4108ZJT translation initiation factor, Sui1 ASZ87_03424 ENOG4105CPF Cell wall formation (By similarity) ASZ87_03426 ENOG4105CD5 CoA-binding domain protein ASZ87_03427 ENOG4105CWB LysR family transcriptional Regulator ASZ87_03431 ENOG4105KA0 thioesterase Superfamily protein ASZ87_03435 ENOG4105CYM Glutathione S-transferase ASZ87_03438 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) ASZ87_03439 ENOG4108JQ5 ABC transporter ASZ87_03440 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component ASZ87_03441 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component ASZ87_03442 ENOG4105E43 Extracellular solute-binding protein, family 5 ASZ87_03447 ENOG4105DUX Transporter ASZ87_03450 ENOG4107RCV ABC transporter, permease ASZ87_03453 ENOG4107STF Involved in phosphonate degradation (By similarity) ASZ87_03454 ENOG4108JPW Aminotransferase ASZ87_03455 ENOG4108KAZ Involved in phosphonate degradation (By similarity) ASZ87_03456 ENOG4105NXH GreA GreB family elongation factor ASZ87_03457 ENOG4105PAD Hydrolase ASZ87_03459 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain ASZ87_03460 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) ASZ87_03461 ENOG4105CKU formyltetrahydrofolate synthetase ASZ87_03462 ENOG4105E0X reductase ASZ87_03463 ENOG4105EUJ GTP cyclohydrolase i ASZ87_03464 ENOG4105CVM Molybdenum cofactor synthesis domain protein ASZ87_03465 ENOG4105D06 uba thif-type nad fad binding protein ASZ87_03467 ENOG4105KHC sulfurtransferase ASZ87_03468 ENOG4107RHR regulatoR ASZ87_03469 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) ASZ87_03470 ENOG4105CV1 Transketolase (EC 2.2.1.1) ASZ87_03476 ENOG4108M3J Dehydrogenase ASZ87_03479 ENOG4105RA2 Membrane ASZ87_03481 ENOG4105ETT transcriptional Regulator, LysR family ASZ87_03482 ENOG41067V3 Antibiotic biosynthesis monooxygenase ASZ87_03483 ENOG4108RCM Nitroreductase ASZ87_03488 ENOG41080HT Transcriptional regulator, arsr family ASZ87_03490 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase ASZ87_03499 ENOG4105C5Y PTS System ASZ87_03500 ENOG4105ETE Transcriptional regulator (LacI family ASZ87_03501 ENOG4107R3K hydrolase ASZ87_03502 ENOG4105D7K pfkb domain protein ASZ87_03503 ENOG4105C6V Glycerol-3-phosphate dehydrogenase ASZ87_03504 ENOG4108NVR Methyl-accepting chemotaxis ASZ87_03505 ENOG4108ZG0 Ompa motb domain protein ASZ87_03506 ENOG4108V1T peptidylprolyl cis-trans isomerase ASZ87_03507 ENOG4107VXZ Hydrolase ASZ87_03508 ENOG4108N3W hemolysin secretion protein ASZ87_03509 ENOG4105CEE C4-dicarboxylate transporter ASZ87_03510 ENOG4105EJQ L-serine dehydratase ASZ87_03514 ENOG4105ETE Transcriptional regulator (LacI family ASZ87_03515 ENOG4105WH1 Two component transcriptional regulator luxr family ASZ87_03516 ENOG4105BZU Histidine kinase ASZ87_03519 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ASZ87_03523 ENOG4105DHT Metal Dependent Phosphohydrolase ASZ87_03524 ENOG4108KX4 response regulator ASZ87_03525 ENOG4105BZU Histidine kinase ASZ87_03526 ENOG4105CXY transporter ASZ87_03527 ENOG4105C4Y ABC transporter ASZ87_03528 ENOG4107RCV ABC transporter, permease ASZ87_03529 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ASZ87_03530 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class ASZ87_03532 ENOG4105CHU acetyl-coa acetyltransferase ASZ87_03534 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ASZ87_03535 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ASZ87_03538 ENOG4105BZU Histidine kinase ASZ87_03539 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) ASZ87_03541 ENOG4108I6A alcohol dehydrogenase ASZ87_03543 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta ASZ87_03545 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC ASZ87_03547 ENOG4105CXY transporter ASZ87_03548 ENOG4105CA9 Pyruvate kinase ASZ87_03549 ENOG4105BZU Histidine kinase ASZ87_03550 ENOG4108SV3 Tmao reductase system periplasmic protein tort ASZ87_03551 ENOG4108Z5K methylglyoxal synthase ASZ87_03552 ENOG4108RWI nicotinamidase ASZ87_03553 ENOG41080IJ Diacylglycerol kinase ASZ87_03556 ENOG41088T4 Helicase IV ASZ87_03557 ENOG4105EM2 membrane ASZ87_03563 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) ASZ87_03564 ENOG4105E0C molybdate abc transporter ASZ87_03565 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein ASZ87_03566 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) ASZ87_03575 ENOG4105BZU Histidine kinase ASZ87_03576 ENOG4108QGH periplasmic ASZ87_03578 ENOG41082IR Excinuclease ABC C subunit domain protein ASZ87_03584 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) ASZ87_03585 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) ASZ87_03586 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A ASZ87_03587 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B ASZ87_03588 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) ASZ87_03589 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) ASZ87_03590 ENOG4105K63 Thioredoxin ASZ87_03596 ENOG4105DUM transcriptional regulator, lysR family ASZ87_03597 ENOG4105DMR ABC, transporter ASZ87_03598 ENOG4105GBT ABC transporter ASZ87_03599 ENOG4106PMH Extracellular solute-binding protein family 3 ASZ87_03600 ENOG4105E5Z arginine transporter ATP-binding subunit ASZ87_03602 ENOG4105EV2 VWA domain protein interacting with AAA ATPase ASZ87_03604 ENOG4108YZ4 nudix hydrolase ASZ87_03605 ENOG4105C5W Aldolase ASZ87_03606 ENOG4106RE7 Cytochrome ASZ87_03607 ENOG4108IG5 Transcriptional regulator ASZ87_03608 ENOG4105C1J atp-dependent rna helicase ASZ87_03609 ENOG4108ZYK Acyl carrier protein phosphodiesterase ASZ87_03611 ENOG4105E0U tyrosine-specific transport protein ASZ87_03612 ENOG4108N3W hemolysin secretion protein ASZ87_03613 ENOG4105CMR udp-glucose 4-epimerase ASZ87_03614 ENOG4105E7W lamb ycsf family protein ASZ87_03616 ENOG4107R7A Allophanate hydrolase subunit 2 ASZ87_03618 ENOG4105C6Y Udp-glucose 6-dehydrogenase ASZ87_03619 ENOG4105CV6 ABC transporter, permease ASZ87_03620 ENOG4108I0Y (ABC) transporter ASZ87_03622 ENOG4105RKW reductase (By ASZ87_03625 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) ASZ87_03634 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) ASZ87_03637 ENOG4107RE1 Inosine-guanosine kinase ASZ87_03638 ENOG4105E0M Sulfatase ASZ87_03640 ENOG4105C1J atp-dependent rna helicase ASZ87_03641 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) ASZ87_03643 ENOG4105CVA phosphate ASZ87_03645 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein ASZ87_03646 ENOG4108M1A Chitin-binding protein ASZ87_03647 ENOG4105D4Y metalloprotease ASZ87_03649 ENOG4105CYW agmatinase ASZ87_03650 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) ASZ87_03652 ENOG4105CJW magnesium transporter ASZ87_03653 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) ASZ87_03654 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) ASZ87_03656 ENOG4105CZK Aspartate kinase ASZ87_03657 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) ASZ87_03658 ENOG4108JPW Aminotransferase ASZ87_03659 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase ASZ87_03660 ENOG41090A4 Pterin carbinolamine dehydratase ASZ87_03661 ENOG4105MIR Phenylalanine 4-monooxygenase ASZ87_03662 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ASZ87_03665 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) ASZ87_03666 ENOG4105EGI Transcriptional regulator ASZ87_03669 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) ASZ87_03670 ENOG4105C37 (CBS) domain ASZ87_03671 ENOG4108UKZ OsmC family ASZ87_03672 ENOG4107YWA deoxycytidylate deaminase ASZ87_03676 ENOG4105DVH amino acid ASZ87_03677 ENOG4106TD9 Diguanylate cyclase ASZ87_03679 ENOG4108VAC response regulator ASZ87_03680 ENOG4108HRK Histidine kinase ASZ87_03683 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ASZ87_03684 ENOG4105C19 ABC transporter ASZ87_03686 ENOG4107RGM aldo keto reductase ASZ87_03687 ENOG4107T9C Alpha amylase catalytic region ASZ87_03688 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation ASZ87_03689 ENOG4108M0H Extracellular lipase ASZ87_03690 ENOG4107SDU Methyl-accepting chemotaxis ASZ87_03691 ENOG4105D4Y metalloprotease ASZ87_03692 ENOG4105EIF outer membrane protein W ASZ87_03694 ENOG41061WM D-Alanyl-D-Alanine ASZ87_03695 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ASZ87_03696 ENOG4105C4M (Ubiquinol oxidase) subunit I ASZ87_03697 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ASZ87_03700 ENOG4105BZC d-serine deaminase ASZ87_03701 ENOG4105W8I Transcriptional regulator ASZ87_03708 ENOG4105CPQ Dehydrogenase ASZ87_03709 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) ASZ87_03710 ENOG4105TMR Functions as a holding molecular chaperone (holdase) which stabilizes unfolding intermediates and rapidly releases them in an active form once stress has abated. Plays an important role in protecting cells from severe heat shock and starvation, as well as in acid resistance of stationary-phase cells. It catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step (By similarity) ASZ87_03711 ENOG4105TMR Functions as a holding molecular chaperone (holdase) which stabilizes unfolding intermediates and rapidly releases them in an active form once stress has abated. Plays an important role in protecting cells from severe heat shock and starvation, as well as in acid resistance of stationary-phase cells. It catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step (By similarity) ASZ87_03713 ENOG4105EXG Transcriptional regulator ASZ87_03714 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase ASZ87_03718 ENOG4107SSZ Phosphatase ASZ87_03719 ENOG4105DHT Metal Dependent Phosphohydrolase ASZ87_03720 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase ASZ87_03721 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) ASZ87_03722 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) ASZ87_03727 ENOG4105BZW Glycerate kinase ASZ87_03728 ENOG4105C6Z Gluconate ASZ87_03729 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR ASZ87_03730 ENOG4108NVR Methyl-accepting chemotaxis ASZ87_03731 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related ASZ87_03732 ENOG41090JE Utilization Protein ASZ87_03733 ENOG4105D4P Coproporphyrinogen iii oxidase ASZ87_03734 ENOG4105WQ5 TonB family ASZ87_03735 ENOG41090AP transport protein ASZ87_03736 ENOG4106GFD transport protein ASZ87_03737 ENOG4107R4I Periplasmic binding protein ASZ87_03738 ENOG4105EHG Permease protein ASZ87_03739 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) ASZ87_03745 ENOG4105C8Q Methyl-accepting chemotaxis ASZ87_03746 ENOG4105QVC MOSC domain-containing protein ASZ87_03746 ENOG4105QVC MOSC domain-containing protein ASZ87_03747 ENOG4105EKE dihydroorotase ASZ87_03749 ENOG4105KAF membrAne ASZ87_03751 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) ASZ87_03752 ENOG4105CKW Inner membrane protein yedI ASZ87_03753 ENOG4108ESY Metal dependent phosphohydrolase ASZ87_03754 ENOG4105VEQ Cold shock protein ASZ87_03759 ENOG4105BZU Histidine kinase ASZ87_03760 ENOG4105E98 transcriptional regulator DeoR family ASZ87_03763 ENOG4105EG2 ABC transporter, permease ASZ87_03764 ENOG4105D56 permease protein ASZ87_03765 ENOG4107FKK extracellular solute-binding protein family 1 ASZ87_03766 ENOG4108IJ9 (ABC) transporter ASZ87_03767 ENOG4108HK0 -acetyltransferase ASZ87_03770 ENOG4105K8R UPF0145 protein ASZ87_03771 ENOG41086KC Transcriptional regulator ASZ87_03772 ENOG4105KQ5 peptidylprolyl cis-trans isomerase ASZ87_03773 ENOG4107R88 Chemotaxis protein (CheV) ASZ87_03774 ENOG4105K56 Transcriptional regulator ASZ87_03775 ENOG4106TD9 Diguanylate cyclase ASZ87_03778 ENOG4105BZU Histidine kinase ASZ87_03782 ENOG4105ETT transcriptional Regulator, LysR family ASZ87_03783 ENOG4108K0B C-di-gmp phosphodiesterase ASZ87_03785 ENOG4105EUB pirin domain protein ASZ87_03786 ENOG4105NBK UPF0345 protein ASZ87_03788 ENOG4105E5W Transporter ASZ87_03790 ENOG4105C8Q Methyl-accepting chemotaxis ASZ87_03791 ENOG4105DAN ATP-dependent protease ASZ87_03793 ENOG4108JQ5 ABC transporter ASZ87_03794 ENOG4105E89 ABC transporter ASZ87_03795 ENOG4105C8Q Methyl-accepting chemotaxis ASZ87_03797 ENOG4105CC0 LysR family Transcriptional regulator ASZ87_03798 ENOG4105DAA L-lactate ASZ87_03799 ENOG4105DMF Dehydrogenase ASZ87_03801 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) ASZ87_03803 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor ASZ87_03805 ENOG4105C1J atp-dependent rna helicase ASZ87_03806 ENOG4105CR8 Transcriptional regulator ASZ87_03808 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ASZ87_03810 ENOG4105BZ1 (ABC) transporter ASZ87_03811 ENOG4105BZ1 (ABC) transporter ASZ87_03812 ENOG4105BZ1 (ABC) transporter ASZ87_03815 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase