locus-tag	class	description
CSW01_00010	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CSW01_00015	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CSW01_00020	COG0706	membrane insertase activity
CSW01_00025	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CSW01_00030	COG0594	ribonuclease P activity
CSW01_00035	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CSW01_00040	COG1126	abc transporter atp-binding protein
CSW01_00055	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CSW01_00060	COG0592	DNA-directed DNA polymerase activity
CSW01_00065	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CSW01_00070	COG0187	DNA topoisomerase II activity
CSW01_00085	COG0071	Belongs to the small heat shock protein (HSP20) family
CSW01_00090	COG3977	Valine--pyruvate aminotransferase
CSW01_00100	COG0751	glycine-tRNA ligase activity
CSW01_00105	COG0752	glycyl-tRNA synthetase alpha subunit
CSW01_00110	COG2119	membrane
CSW01_00120	COG0425	Belongs to the sulfur carrier protein TusA family
CSW01_00130	COG0604	alcohol dehydrogenase
CSW01_00140	COG0129	dihydroxy-acid dehydratase activity
CSW01_00145	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CSW01_00160	COG0606	chelatase, subunit chli
CSW01_00165	COG0204	Acyl-transferase
CSW01_00170	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CSW01_00175	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CSW01_00190	COG3084	Protein conserved in bacteria
CSW01_00200	COG4326	sporulation control protein
CSW01_00205	COG1272	protein, Hemolysin III
CSW01_00215	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CSW01_00220	COG0569	domain protein
CSW01_00225	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CSW01_00225	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CSW01_00230	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CSW01_00235	COG0242	peptide deformylase activity
CSW01_00240	COG1652	LysM domain
CSW01_00245	COG0758	DNA mediated transformation
CSW01_00250	COG2922	Belongs to the Smg family
CSW01_00255	COG0551	DNA topoisomerase type I activity
CSW01_00260	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CSW01_00265	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CSW01_00270	COG0009	L-threonylcarbamoyladenylate synthase
CSW01_00275	COG0408	coproporphyrinogen oxidase activity
CSW01_00280	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CSW01_00290	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CSW01_00330	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CSW01_00335	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CSW01_00345	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CSW01_00350	COG2104	thiamine diphosphate biosynthetic process
CSW01_00355	COG2022	thiamine diphosphate biosynthetic process
CSW01_00360	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CSW01_00365	COG0006	proline dipeptidase activity
CSW01_00365	COG0006	proline dipeptidase activity
CSW01_00385	COG1522	sequence-specific DNA binding
CSW01_00390	COG5001	Diguanylate cyclase
CSW01_00390	COG5002	protein histidine kinase activity
CSW01_00395	COG0742	ribosomal rna small subunit methyltransferase
CSW01_00405	COG0697	spore germination
CSW01_00410	COG0589	response to stress
CSW01_00420	COG1528	Iron-storage protein
CSW01_00430	COG2081	HI0933 family
CSW01_00440	COG1322	Protein conserved in bacteria
CSW01_00445	COG2226	methyltransferase
CSW01_00455	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CSW01_00460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CSW01_00465	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CSW01_00470	COG0805	protein transport
CSW01_00475	COG1858	cytochrome C peroxidase
CSW01_00480	COG0534	Mate efflux family protein
CSW01_00490	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CSW01_00500	COG2937	Belongs to the GPAT DAPAT family
CSW01_00505	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CSW01_00510	COG3161	chorismate lyase activity
CSW01_00520	COG1580	Controls the rotational direction of flagella during chemotaxis
CSW01_00525	COG0840	transmembrane signaling receptor activity
CSW01_00535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CSW01_00545	COG0084	hydrolase, TatD family'
CSW01_00560	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CSW01_00560	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CSW01_00565	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CSW01_00580	COG3078	GTPase activator activity
CSW01_00590	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CSW01_00595	COG3071	HemY protein
CSW01_00600	COG2959	enzyme of heme biosynthesis
CSW01_00605	COG1587	Uroporphyrinogen-III synthase
CSW01_00610	COG0181	hydroxymethylbilane synthase activity
CSW01_00620	COG3072	Adenylate cyclase
CSW01_00625	COG1965	Belongs to the frataxin family
CSW01_00635	COG0019	diaminopimelate decarboxylase activity
CSW01_00640	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CSW01_00650	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CSW01_00655	COG1011	Hydrolase
CSW01_00660	COG2199	diguanylate cyclase activity
CSW01_00660	COG2200	EAL domain
CSW01_00660	COG3287	FIST C domain
CSW01_00680	COG0561	phosphatase activity
CSW01_00685	COG2267	carboxylic ester hydrolase activity
CSW01_00690	COG1280	lysine exporter protein (LysE YggA)
CSW01_00695	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CSW01_00700	COG0783	Belongs to the Dps family
CSW01_00740	COG0742	ribosomal rna small subunit methyltransferase
CSW01_00745	COG0552	protein localization to endoplasmic reticulum
CSW01_00750	COG2884	Cell division ATP-binding protein ftsE
CSW01_00755	COG2177	Part of the ABC transporter FtsEX involved in
CSW01_00760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CSW01_00765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CSW01_00785	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CSW01_00790	COG4206	TonB-dependent receptor
CSW01_00795	COG1404	Belongs to the peptidase S8 family
CSW01_00800	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CSW01_00835	COG0583	DNA-binding transcription factor activity
CSW01_00840	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CSW01_00845	COG2960	long-chain fatty acid transporting porin activity
CSW01_00850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CSW01_00855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CSW01_00860	COG1309	transcriptional regulator
CSW01_00915	COG0747	negative chemotaxis
CSW01_00925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CSW01_00935	COG2131	deaminase
CSW01_01000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CSW01_01005	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CSW01_01015	COG0210	DNA helicase
CSW01_01025	COG1280	lysine exporter protein (LysE YggA)
CSW01_01040	COG2962	Rard protein
CSW01_01045	COG0514	ATP-dependent DNA helicase (RecQ)
CSW01_01060	COG1132	(ABC) transporter
CSW01_01065	COG4774	siderophore transport
CSW01_01070	COG1120	ATPase activity
CSW01_01095	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CSW01_01100	COG1263	PTS System
CSW01_01100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CSW01_01110	COG1561	YicC-like family, N-terminal region
CSW01_01115	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CSW01_01120	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CSW01_01125	COG1560	Kdo2-lipid A biosynthetic process
CSW01_01130	COG1560	Kdo2-lipid A biosynthetic process
CSW01_01135	COG1309	transcriptional regulator
CSW01_01145	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CSW01_01160	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CSW01_01165	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CSW01_01175	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CSW01_01180	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CSW01_01185	COG0859	PFAM glycosyl transferase family 9
CSW01_01190	COG0463	Glycosyl transferase, family 2
CSW01_01195	COG0859	PFAM glycosyl transferase family 9
CSW01_01200	COG3642	lipopolysaccharide core region biosynthetic process
CSW01_01230	COG1519	Transferase
CSW01_01265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CSW01_01270	COG0662	Cupin 2, conserved barrel domain protein
CSW01_01270	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CSW01_01275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CSW01_01280	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CSW01_01310	COG0318	PFAM AMP-dependent synthetase and ligase
CSW01_01315	COG1454	alcohol dehydrogenase
CSW01_01315	COG1012	belongs to the aldehyde dehydrogenase family
CSW01_01360	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CSW01_01365	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CSW01_01370	COG0668	transmembrane transport
CSW01_01375	COG1573	uracil-dna glycosylase
CSW01_01385	COG3068	Protein conserved in bacteria
CSW01_01395	COG1940	carbohydrate kinase activity
CSW01_01400	COG1253	flavin adenine dinucleotide binding
CSW01_01405	COG0776	regulation of translation
CSW01_01415	COG0151	Belongs to the GarS family
CSW01_01420	COG0138	bifunctional purine biosynthesis protein purh
CSW01_01430	COG0789	Transcriptional regulator
CSW01_01435	COG3710	Transcriptional regulator
CSW01_01440	COG0531	amino acid
CSW01_01445	COG1982	Orn Lys Arg decarboxylase major
CSW01_01450	COG0840	transmembrane signaling receptor activity
CSW01_01465	COG0800	Aldolase
CSW01_01475	COG3265	gluconokinase activity
CSW01_01480	COG0129	dihydroxy-acid dehydratase activity
CSW01_01485	COG1609	Transcriptional regulator
CSW01_01490	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CSW01_01495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CSW01_01500	COG2264	protein methyltransferase activity
CSW01_01505	COG0439	Biotin carboxylase
CSW01_01510	COG0511	ligase activity, forming carbon-carbon bonds
CSW01_01515	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CSW01_01520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CSW01_01540	COG2814	Major facilitator Superfamily
CSW01_01545	COG0784	Response regulator, receiver
CSW01_01545	COG2205	protein histidine kinase activity
CSW01_01550	COG0248	Ppx GppA phosphatase
CSW01_01555	COG0513	Belongs to the DEAD box helicase family
CSW01_01560	COG3118	belongs to the thioredoxin family
CSW01_01565	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CSW01_01575	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CSW01_01620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CSW01_01630	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CSW01_01640	COG1072	(Pantothenic acid kinase))
CSW01_01665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CSW01_01670	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CSW01_01675	COG0250	Participates in transcription elongation, termination and antitermination
CSW01_01680	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CSW01_01685	COG0081	regulation of translation
CSW01_01690	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CSW01_01695	COG0222	ribosome binding
CSW01_01700	COG0085	RNA polymerase activity
CSW01_01705	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CSW01_01710	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
CSW01_01715	COG2816	NAD+ diphosphatase activity
CSW01_01720	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CSW01_01735	COG4942	peptidase
CSW01_01740	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CSW01_01750	COG0490	domain, Protein
CSW01_01750	COG0471	metal ion transport
CSW01_01755	COG0688	phosphatidylethanolamine metabolic process
CSW01_01765	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CSW01_01810	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CSW01_01815	COG0802	atpase or kinase
CSW01_01825	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CSW01_01830	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CSW01_01835	COG1923	regulation of RNA biosynthetic process
CSW01_01840	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CSW01_01845	COG0330	HflC and HflK could
CSW01_01850	COG0330	HflC and HflK could
CSW01_01855	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CSW01_01860	COG2900	Belongs to the SlyX family
CSW01_01870	COG0545	Peptidyl-prolyl cis-trans isomerase
CSW01_01875	COG2964	Protein conserved in bacteria
CSW01_01880	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CSW01_01885	COG2923	Belongs to the DsrF TusC family
CSW01_01895	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CSW01_01900	COG0049	tRNA binding
CSW01_01905	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CSW01_01910	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CSW01_01915	COG2906	2 iron, 2 sulfur cluster binding
CSW01_01925	COG0360	Binds together with S18 to 16S ribosomal RNA
CSW01_01930	COG2965	DNA replication, synthesis of RNA primer
CSW01_01935	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CSW01_01940	COG0359	binds to the 23S rRNA
CSW01_01950	COG0305	Participates in initiation and elongation during chromosome replication
CSW01_01955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CSW01_01960	COG0432	Pfam Uncharacterised protein family UPF0047
CSW01_01965	COG0166	Belongs to the GPI family
CSW01_01980	COG0735	belongs to the Fur family
CSW01_01985	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CSW01_02010	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CSW01_02015	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CSW01_02020	COG0175	sulfate reduction
CSW01_02060	COG0646	methionine synthase
CSW01_02060	COG1410	methionine synthase
CSW01_02065	COG0527	aspartate kinase activity
CSW01_02070	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CSW01_02080	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CSW01_02095	COG0629	single-stranded DNA binding
CSW01_02100	COG2199	diguanylate cyclase activity
CSW01_02100	COG2200	EAL domain
CSW01_02125	COG3409	Peptidoglycan-binding domain 1 protein
CSW01_02125	COG3267	Type II secretory pathway component ExeA
CSW01_02135	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CSW01_02140	COG1459	type II secretion system
CSW01_02185	COG1077	Cell shape determining protein MreB Mrl
CSW01_02190	COG1792	Involved in formation and maintenance of cell shape
CSW01_02195	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CSW01_02200	COG0424	maF-like protein
CSW01_02205	COG1530	ribonuclease E activity
CSW01_02210	COG3164	Protein of unknown function
CSW01_02215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CSW01_02220	COG0312	modulator of DNA gyrase
CSW01_02225	COG2235	arginine
CSW01_02245	COG0589	response to stress
CSW01_02265	COG1438	arginine binding
CSW01_02270	COG0039	L-malate dehydrogenase activity
CSW01_02275	COG0531	amino acid
CSW01_02280	COG0142	geranyltranstransferase activity
CSW01_02285	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CSW01_02290	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CSW01_02295	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CSW01_02300	COG2966	Psort location CytoplasmicMembrane, score
CSW01_02305	COG3610	response to peptide
CSW01_02315	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CSW01_02320	COG2967	ApaG domain
CSW01_02325	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CSW01_02330	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CSW01_02335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CSW01_02340	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CSW01_02345	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CSW01_02400	COG0741	lytic transglycosylase activity
CSW01_02405	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CSW01_02410	COG1194	a g-specific adenine glycosylase
CSW01_02415	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CSW01_02420	COG2066	Belongs to the glutaminase family
CSW01_02425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CSW01_02430	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CSW01_02440	COG1872	DUF167
CSW01_02445	COG0762	integral membrane protein
CSW01_02450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CSW01_02455	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CSW01_02475	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CSW01_02480	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CSW01_02485	COG1678	Uncharacterized ACR, COG1678
CSW01_02490	COG0189	ligase activity
CSW01_02495	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CSW01_02500	COG2356	endonuclease I
CSW01_02505	COG3091	SprT-like family
CSW01_02510	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CSW01_02515	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CSW01_02520	COG0583	DNA-binding transcription factor activity
CSW01_02525	COG4771	TonB-dependent receptor
CSW01_02530	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CSW01_02535	COG0126	phosphoglycerate kinase activity
CSW01_02540	COG0191	fructose-bisphosphate aldolase activity
CSW01_02550	COG0668	transmembrane transport
CSW01_02555	COG1279	arginine transmembrane transporter activity
CSW01_02560	COG0583	DNA-binding transcription factor activity
CSW01_02575	COG0469	pyruvate kinase activity
CSW01_02580	COG1349	DNA-binding transcription factor activity
CSW01_02585	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CSW01_02590	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CSW01_02640	COG0328	RNA-DNA hybrid ribonuclease activity
CSW01_02665	COG0739	heme binding
CSW01_02700	COG2003	Belongs to the UPF0758 family
CSW01_02710	COG0840	transmembrane signaling receptor activity
CSW01_02720	COG2207	Transcriptional regulator
CSW01_02725	COG0840	transmembrane signaling receptor activity
CSW01_02730	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CSW01_02735	COG0582	viral genome integration into host DNA
CSW01_02745	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CSW01_02750	COG0358	DNA primase activity
CSW01_02755	COG1610	YqeY-like protein
CSW01_02760	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CSW01_02765	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CSW01_02775	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CSW01_02785	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CSW01_02790	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CSW01_02795	COG1968	undecaprenyl-diphosphatase activity
CSW01_02800	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CSW01_02805	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CSW01_02810	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CSW01_02815	COG0585	pseudouridine synthase activity
CSW01_02820	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CSW01_02825	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CSW01_02830	COG4942	peptidase
CSW01_02830	COG1388	LysM domain
CSW01_02835	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CSW01_02840	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CSW01_02860	COG4208	sulfate ABC transporter
CSW01_02865	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CSW01_02875	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CSW01_02880	COG2137	regulation of response to DNA damage stimulus
CSW01_02885	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CSW01_02890	COG0527	aspartate kinase activity
CSW01_02895	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CSW01_02940	COG3630	sodium ion export across plasma membrane
CSW01_02945	COG0511	ligase activity, forming carbon-carbon bonds
CSW01_02945	COG5016	pyruvate
CSW01_02950	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CSW01_02960	COG1238	metal cluster binding
CSW01_02965	COG0612	Peptidase, M16
CSW01_02970	COG2918	glutathione biosynthetic process
CSW01_02975	COG1854	S-ribosylhomocysteine lyase activity
CSW01_02980	COG4536	flavin adenine dinucleotide binding
CSW01_02985	COG4137	Cytochrome C assembly protein
CSW01_02990	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CSW01_02995	COG0228	four-way junction DNA binding
CSW01_03000	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CSW01_03005	COG0336	Belongs to the RNA methyltransferase TrmD family
CSW01_03010	COG0335	large ribosomal subunit rRNA binding
CSW01_03015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CSW01_03020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CSW01_03030	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CSW01_03035	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CSW01_03040	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CSW01_03045	COG0723	plastoquinol--plastocyanin reductase activity
CSW01_03050	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CSW01_03055	COG2857	Cytochrome c1
CSW01_03060	COG0625	glutathione transferase activity
CSW01_03065	COG2969	positive regulation of protein catabolic process
CSW01_03070	COG2823	Periplasmic or secreted lipoprotein
CSW01_03075	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CSW01_03080	COG0792	nuclease activity
CSW01_03085	COG3107	peptidoglycan biosynthetic process
CSW01_03090	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CSW01_03110	COG0288	reversible hydration of carbon dioxide
CSW01_03115	COG0659	secondary active sulfate transmembrane transporter activity
CSW01_03120	COG1131	(ABC) transporter
CSW01_03125	COG0842	Transport permease protein
CSW01_03130	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CSW01_03135	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CSW01_03140	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CSW01_03150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CSW01_03155	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CSW01_03160	COG1489	DNA binding
CSW01_03170	COG1643	Atp-dependent helicase
CSW01_03175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CSW01_03180	COG1752	Esterase of the alpha-beta hydrolase superfamily
CSW01_03185	COG1049	propionate catabolic process, 2-methylcitrate cycle
CSW01_03190	COG3112	Uncharacterised protein family (UPF0231)
CSW01_03195	COG0347	Belongs to the P(II) protein family
CSW01_03200	COG0004	ammonium transporteR
CSW01_03205	COG1840	ABC-type Fe3 transport system, periplasmic component
CSW01_03215	COG3842	ATPase activity
CSW01_03235	COG2971	BadF BadG BcrA BcrD
CSW01_03245	COG4608	Belongs to the ABC transporter superfamily
CSW01_03250	COG0444	Belongs to the ABC transporter superfamily
CSW01_03255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CSW01_03260	COG0601	transmembrane transport
CSW01_03265	COG0747	negative chemotaxis
CSW01_03280	COG2813	Specifically methylates the guanine in position
CSW01_03285	COG0628	permease
CSW01_03290	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CSW01_03295	COG0316	Belongs to the HesB IscA family
CSW01_03310	COG0739	heme binding
CSW01_03315	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CSW01_03320	COG2027	D-alanyl-D-alanine carboxypeptidase
CSW01_03325	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CSW01_03330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CSW01_03335	COG1534	Rna-binding protein
CSW01_03340	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CSW01_03345	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CSW01_03350	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CSW01_03355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CSW01_03365	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CSW01_03380	COG0779	Required for maturation of 30S ribosomal subunits
CSW01_03385	COG0195	Participates in both transcription termination and antitermination
CSW01_03390	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CSW01_03395	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CSW01_03400	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CSW01_03405	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CSW01_03410	COG1185	polyribonucleotide nucleotidyltransferase activity
CSW01_03415	COG4785	May be involved in cell division
CSW01_03450	COG3153	acetyltransferase
CSW01_03470	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CSW01_03475	COG0513	Belongs to the DEAD box helicase family
CSW01_03480	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CSW01_03495	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CSW01_03500	COG2204	response regulator
CSW01_03510	COG0667	Aldo Keto reductase
CSW01_03515	COG3066	DNA modification
CSW01_03520	COG0494	nUDIX hydrolase
CSW01_03525	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
CSW01_03530	COG0730	response to heat
CSW01_03535	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CSW01_03540	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CSW01_03545	COG1283	sodium-dependent phosphate transmembrane transporter activity
CSW01_03550	COG0583	DNA-binding transcription factor activity
CSW01_03555	COG0640	Transcriptional regulator
CSW01_03560	COG0268	Binds directly to 16S ribosomal RNA
CSW01_03565	COG0728	peptidoglycan biosynthetic process
CSW01_03570	COG0196	riboflavin kinase activity
CSW01_03575	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CSW01_03580	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CSW01_03585	COG1047	Peptidyl-prolyl cis-trans
CSW01_03590	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CSW01_03595	COG1966	Carbon starvation protein
CSW01_03610	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CSW01_03615	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CSW01_03620	COG1472	Belongs to the glycosyl hydrolase 3 family
CSW01_03625	COG3279	Response regulator of the LytR AlgR family
CSW01_03630	COG3275	phosphorelay sensor kinase activity
CSW01_03635	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CSW01_03640	COG0287	Prephenate dehydrogenase
CSW01_03640	COG1605	Chorismate mutase
CSW01_03650	COG0488	(ABC) transporter
CSW01_03660	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
CSW01_03665	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CSW01_03670	COG5001	Diguanylate cyclase
CSW01_03675	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CSW01_03680	COG1605	Chorismate mutase
CSW01_03680	COG0077	Prephenate dehydratase
CSW01_03685	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CSW01_03690	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CSW01_03695	COG0564	pseudouridine synthase activity
CSW01_03705	COG0542	response to heat
CSW01_03745	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CSW01_03755	COG2974	May be involved in recombination
CSW01_03760	COG0745	RESPONSE REGULATOR receiver
CSW01_03765	COG5002	protein histidine kinase activity
CSW01_03775	COG0248	Ppx GppA phosphatase
CSW01_03780	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CSW01_03790	COG0581	inorganic phosphate transmembrane transporter activity
CSW01_03795	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CSW01_03810	COG3142	Participates in the control of copper homeostasis
CSW01_03815	COG0450	alkyl hydroperoxide reductase
CSW01_03820	COG0583	DNA-binding transcription factor activity
CSW01_03825	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CSW01_03835	COG0517	IMP dehydrogenase activity
CSW01_03840	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CSW01_03850	COG0343	queuine tRNA-ribosyltransferase activity
CSW01_03855	COG1862	Preprotein translocase
CSW01_03860	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CSW01_03865	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CSW01_03870	COG0483	inositol monophosphate 1-phosphatase activity
CSW01_03880	COG1959	2 iron, 2 sulfur cluster binding
CSW01_03885	COG1104	cysteine desulfurase activity
CSW01_03890	COG0822	iron-sulfur transferase activity
CSW01_03900	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CSW01_03905	COG0443	Heat shock 70 kDa protein
CSW01_03910	COG0633	Ferredoxin
CSW01_03915	COG2975	iron-sulfur cluster assembly
CSW01_03920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CSW01_03925	COG0105	UTP biosynthetic process
CSW01_03930	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CSW01_03940	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CSW01_03945	COG0124	histidyl-tRNA synthetase
CSW01_03950	COG2976	Protein conserved in bacteria
CSW01_03955	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CSW01_03960	COG1160	GTP binding
CSW01_03975	COG1570	exodeoxyribonuclease VII activity
CSW01_03980	COG0517	IMP dehydrogenase activity
CSW01_03980	COG0516	GMP reductase activity
CSW01_03985	COG0519	Catalyzes the synthesis of GMP from XMP
CSW01_03985	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CSW01_03995	COG1584	GPR1 FUN34 yaaH family protein
CSW01_04000	COG1535	isochorismatase
CSW01_04000	COG3433	isochorismatase activity
CSW01_04005	COG1021	2,3-dihydroxybenzoate-AMP ligase
CSW01_04010	COG1169	isochorismate synthase
CSW01_04015	COG1028	Short-chain dehydrogenase reductase Sdr
CSW01_04025	COG4592	Periplasmic binding protein
CSW01_04030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CSW01_04035	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CSW01_04040	COG1120	ATPase activity
CSW01_04050	COG0583	DNA-binding transcription factor activity
CSW01_04055	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CSW01_04060	COG1115	amino acid carrier protein
CSW01_04065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CSW01_04070	COG0583	DNA-binding transcription factor activity
CSW01_04085	COG4565	transcriptional regulatory protein
CSW01_04095	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CSW01_04100	COG0511	ligase activity, forming carbon-carbon bonds
CSW01_04100	COG5016	pyruvate
CSW01_04105	COG3630	sodium ion export across plasma membrane
CSW01_04115	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
CSW01_04120	COG3052	prosthetic group binding
CSW01_04125	COG2301	Belongs to the HpcH HpaI aldolase family
CSW01_04130	COG3051	citrate lyase alpha subunit
CSW01_04135	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
CSW01_04140	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
CSW01_04150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CSW01_04155	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CSW01_04160	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CSW01_04225	COG1012	belongs to the aldehyde dehydrogenase family
CSW01_04245	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CSW01_04250	COG0840	transmembrane signaling receptor activity
CSW01_04255	COG3710	Transcriptional regulator
CSW01_04265	COG2165	general secretion pathway protein
CSW01_04280	COG4796	Type ii and iii secretion system protein
CSW01_04300	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CSW01_04305	COG1459	type II secretion system
CSW01_04315	COG2207	Transcriptional regulator
CSW01_04320	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CSW01_04325	COG0840	transmembrane signaling receptor activity
CSW01_04340	COG0739	heme binding
CSW01_04350	COG3064	Membrane
CSW01_04355	COG0582	viral genome integration into host DNA
CSW01_04365	COG0582	viral genome integration into host DNA
CSW01_04375	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CSW01_04380	COG2867	negative regulation of translational initiation
CSW01_04385	COG2914	Belongs to the UPF0125 (RnfH) family
CSW01_04390	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CSW01_04395	COG0497	DNA recombination
CSW01_04400	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CSW01_04405	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CSW01_04410	COG0443	Heat shock 70 kDa protein
CSW01_04415	COG0484	heat shock protein binding
CSW01_04425	COG4968	Prepilin-type N-terminal cleavage methylation domain
CSW01_04450	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CSW01_04455	COG0590	tRNA wobble adenosine to inosine editing
CSW01_04460	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CSW01_04470	COG0047	phosphoribosylformylglycinamidine synthase activity
CSW01_04470	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CSW01_04475	COG1943	Transposase
CSW01_04500	COG0442	prolyl-tRNA aminoacylation
CSW01_04505	COG1720	tRNA m6t6A37 methyltransferase activity
CSW01_04510	COG0254	rRNA binding
CSW01_04515	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CSW01_04520	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CSW01_04525	COG1671	Belongs to the UPF0178 family
CSW01_04535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CSW01_04550	COG3098	single-species biofilm formation
CSW01_04555	COG0564	pseudouridine synthase activity
CSW01_04560	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CSW01_04565	COG0142	geranyltranstransferase activity
CSW01_04570	COG1722	exodeoxyribonuclease VII activity
CSW01_04575	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CSW01_04585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CSW01_04585	COG0301	tRNA thio-modification
CSW01_04590	COG0583	DNA-binding transcription factor activity
CSW01_04595	COG2363	Small membrane protein
CSW01_04600	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CSW01_04605	COG1611	Belongs to the LOG family
CSW01_04610	COG3706	GGDEF domain
CSW01_04620	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CSW01_04620	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CSW01_04630	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
CSW01_04635	COG1464	Belongs to the NlpA lipoprotein family
CSW01_04640	COG2011	ABC-type metal ion transport system permease component
CSW01_04645	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CSW01_04650	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CSW01_04655	COG1609	Transcriptional regulator
CSW01_04660	COG1263	PTS System
CSW01_04660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CSW01_04665	COG0366	Alpha amylase catalytic
CSW01_04695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CSW01_04700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CSW01_04705	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CSW01_04710	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CSW01_04715	COG0110	maltose O-acetyltransferase activity
CSW01_04735	COG1045	serine acetyltransferase
CSW01_04745	COG0438	transferase activity, transferring glycosyl groups
CSW01_04755	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CSW01_04785	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CSW01_04795	COG1596	polysaccharide export
CSW01_04820	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CSW01_04830	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CSW01_04835	COG0321	lipoyl(octanoyl) transferase activity
CSW01_04840	COG2921	Belongs to the UPF0250 family
CSW01_04845	COG1686	Belongs to the peptidase S11 family
CSW01_04850	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CSW01_04855	COG0772	Belongs to the SEDS family
CSW01_04860	COG0768	penicillin binding
CSW01_04865	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CSW01_04870	COG0799	negative regulation of ribosome biogenesis
CSW01_04875	COG1466	dna polymerase III delta subunit
CSW01_04880	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
CSW01_04885	COG0495	leucyl-tRNA aminoacylation
CSW01_04890	COG2888	peptidyl-tyrosine sulfation
CSW01_04895	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CSW01_04900	COG4535	Mg2 and Co2 transporter CorC
CSW01_04905	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CSW01_04910	COG1702	phosphate starvation-inducible protein PhoH
CSW01_04915	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CSW01_04920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CSW01_04925	COG2190	(PTS) system
CSW01_04935	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CSW01_04945	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CSW01_04950	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
CSW01_04955	COG3115	cell septum assembly
CSW01_04960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CSW01_04975	COG0789	Transcriptional regulator
CSW01_04980	COG1585	Membrane protein implicated in regulation of membrane protease activity
CSW01_04985	COG0330	HflC and HflK could
CSW01_04995	COG3118	belongs to the thioredoxin family
CSW01_05000	COG0300	oxidoreductase activity
CSW01_05005	COG1090	epimerase
CSW01_05010	COG0622	Phosphoesterase
CSW01_05025	COG3710	Transcriptional regulator
CSW01_05030	COG0326	Molecular chaperone. Has ATPase activity
CSW01_05035	COG0563	adenylate kinase activity
CSW01_05040	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CSW01_05055	COG0367	asparagine synthase
CSW01_05060	COG4651	solute:proton antiporter activity
CSW01_05060	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CSW01_05065	COG1940	carbohydrate kinase activity
CSW01_05065	COG1846	Transcriptional regulator
CSW01_05070	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CSW01_05075	COG1263	PTS System
CSW01_05075	COG2190	(PTS) system
CSW01_05075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CSW01_05080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CSW01_05090	COG0101	tRNA pseudouridine synthase activity
CSW01_05095	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CSW01_05100	COG0285	dihydrofolate synthase activity
CSW01_05105	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CSW01_05110	COG1286	toxin biosynthetic process
CSW01_05115	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CSW01_05120	COG2056	Na+-H+ antiporter family
CSW01_05125	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CSW01_05140	COG0346	lactoylglutathione lyase activity
CSW01_05145	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CSW01_05150	COG4660	Part of a membrane complex involved in electron transport
CSW01_05155	COG4659	FMN binding
CSW01_05160	COG4658	electron transport chain
CSW01_05165	COG4656	Part of a membrane complex involved in electron transport
CSW01_05170	COG2878	Part of a membrane complex involved in electron transport
CSW01_05175	COG4657	Part of a membrane complex involved in electron transport
CSW01_05185	COG0556	nucleotide-excision repair
CSW01_05195	COG2204	response regulator
CSW01_05200	COG2198	Histidine kinase
CSW01_05205	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CSW01_05210	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CSW01_05215	COG0521	Mo-molybdopterin cofactor biosynthetic process
CSW01_05220	COG0315	cyclic pyranopterin monophosphate synthase activity
CSW01_05225	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CSW01_05230	COG0314	molybdopterin synthase activity
CSW01_05235	COG2199	diguanylate cyclase activity
CSW01_05240	COG4109	DRTGG domain
CSW01_05255	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CSW01_05265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CSW01_05265	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CSW01_05270	COG0489	protein tyrosine kinase activity
CSW01_05280	COG0572	uridine kinase
CSW01_05285	COG2982	Protein involved in outer membrane biogenesis
CSW01_05290	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CSW01_05295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CSW01_05305	COG2067	long-chain fatty acid transport protein
CSW01_05325	COG0183	Belongs to the thiolase family
CSW01_05330	COG1024	Enoyl-CoA hydratase
CSW01_05330	COG1250	3-hydroxyacyl-CoA dehydrogenase
CSW01_05335	COG0778	Nitroreductase
CSW01_05340	COG0583	DNA-binding transcription factor activity
CSW01_05345	COG0745	RESPONSE REGULATOR receiver
CSW01_05355	COG2832	Protein of unknown function (DUF454)
CSW01_05360	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CSW01_05370	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CSW01_05375	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CSW01_05390	COG1028	Short-chain dehydrogenase reductase Sdr
CSW01_05395	COG0616	signal peptide processing
CSW01_05405	COG1522	sequence-specific DNA binding
CSW01_05410	COG1946	Acyl-CoA thioesterase
CSW01_05430	COG3706	GGDEF domain
CSW01_05440	COG0640	Transcriptional regulator
CSW01_05445	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CSW01_05470	COG1881	PFAM PEBP family protein
CSW01_05490	COG0009	L-threonylcarbamoyladenylate synthase
CSW01_05505	COG2201	protein-glutamate methylesterase activity
CSW01_05515	COG5002	protein histidine kinase activity
CSW01_05520	COG4191	Histidine kinase
CSW01_05525	COG3300	MHYT domain
CSW01_05525	COG5001	Diguanylate cyclase
CSW01_05530	COG2204	response regulator
CSW01_05550	COG0601	transmembrane transport
CSW01_05555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CSW01_05560	COG0444	Belongs to the ABC transporter superfamily
CSW01_05565	COG4608	Belongs to the ABC transporter superfamily
CSW01_05570	COG0435	Glutathione S-transferase
CSW01_05575	COG0857	belongs to the CobB CobQ family
CSW01_05575	COG0280	phosphate acetyltransferase
CSW01_05580	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CSW01_05585	COG3092	negative regulation of chromosome organization
CSW01_05590	COG4628	conserved protein (DUF2132)
CSW01_05600	COG4120	Belongs to the binding-protein-dependent transport system permease family
CSW01_05610	COG2203	Gaf domain
CSW01_05610	COG2199	diguanylate cyclase activity
CSW01_05615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CSW01_05625	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CSW01_05630	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CSW01_05635	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CSW01_05640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CSW01_05645	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CSW01_05650	COG0156	8-amino-7-oxononanoate synthase activity
CSW01_05655	COG2226	methyltransferase
CSW01_05660	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CSW01_05670	COG0501	Belongs to the peptidase M48B family
CSW01_05680	COG0300	oxidoreductase activity
CSW01_05695	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CSW01_05705	COG2268	Band 7 protein
CSW01_05715	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CSW01_05720	COG2915	High frequency lysogenization protein hflD homolog
CSW01_05725	COG0482	sulfurtransferase activity
CSW01_05730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CSW01_05735	COG2916	Histone family protein nucleoid-structuring protein H-NS
CSW01_05740	COG1757	Na H antiporter
CSW01_05745	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CSW01_05750	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CSW01_05755	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CSW01_05760	COG0131	Imidazoleglycerol-phosphate dehydratase
CSW01_05760	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CSW01_05765	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CSW01_05770	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CSW01_05775	COG0107	imidazoleglycerol-phosphate synthase activity
CSW01_05780	COG0140	phosphoribosyl-ATP diphosphatase activity
CSW01_05780	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CSW01_05785	COG1187	pseudouridine synthase activity
CSW01_05795	COG1278	Cold shock
CSW01_05800	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CSW01_05805	COG0542	response to heat
CSW01_05815	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CSW01_05820	COG1454	alcohol dehydrogenase
CSW01_05820	COG1012	belongs to the aldehyde dehydrogenase family
CSW01_05825	COG1737	Transcriptional regulator
CSW01_05830	COG0076	glutamate decarboxylase activity
CSW01_05840	COG2431	L-lysine efflux transmembrane transporter activity
CSW01_05850	COG3070	regulator of competence-specific genes
CSW01_05865	COG3852	Histidine kinase
CSW01_05875	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CSW01_05890	COG0189	ligase activity
CSW01_05890	COG4067	protein conserved in archaea
CSW01_05895	COG0500	methyltransferase
CSW01_05900	COG4106	trans-aconitate 2-methyltransferase activity
CSW01_05905	COG1801	Protein of unknown function DUF72
CSW01_05910	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CSW01_05915	COG1435	thymidine kinase activity
CSW01_05925	COG0159	tryptophan synthase activity
CSW01_05930	COG0133	tryptophan synthase activity
CSW01_05935	COG0135	phosphoribosylanthranilate isomerase activity
CSW01_05935	COG0134	indole-3-glycerol-phosphate synthase activity
CSW01_05940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CSW01_05945	COG0512	Glutamine amidotransferase of anthranilate synthase
CSW01_05950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CSW01_05960	COG0613	PHP domain protein
CSW01_05965	COG0009	L-threonylcarbamoyladenylate synthase
CSW01_05970	COG1187	pseudouridine synthase activity
CSW01_05975	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CSW01_05980	COG4988	ABC transporter
CSW01_05985	COG0492	ferredoxin-NADP+ reductase activity
CSW01_05995	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CSW01_06000	COG3706	GGDEF domain
CSW01_06005	COG2949	membrane
CSW01_06015	COG0281	malic enzyme
CSW01_06025	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CSW01_06045	COG2885	chlorophyll binding
CSW01_06060	COG0247	lactate metabolic process
CSW01_06060	COG0277	FAD linked oxidase domain protein
CSW01_06080	COG2986	histidine ammonia-lyase
CSW01_06085	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CSW01_06090	COG0010	Belongs to the arginase family
CSW01_06095	COG1228	amidohydrolase
CSW01_06115	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CSW01_06125	COG5001	Diguanylate cyclase
CSW01_06130	COG0417	DNA replication proofreading
CSW01_06135	COG2197	response regulator
CSW01_06140	COG0322	excinuclease ABC activity
CSW01_06170	COG0745	RESPONSE REGULATOR receiver
CSW01_06170	COG3706	GGDEF domain
CSW01_06180	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CSW01_06185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CSW01_06185	COG0072	phenylalanine-tRNA ligase activity
CSW01_06190	COG0776	regulation of translation
CSW01_06205	COG0500	methyltransferase
CSW01_06225	COG0295	cytidine deaminase activity
CSW01_06230	COG1346	cytolysis
CSW01_06240	COG2925	Exonuclease
CSW01_06250	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CSW01_06260	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CSW01_06265	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CSW01_06280	COG2988	succinylglutamate desuccinylase activity
CSW01_06285	COG4139	cobalamin transport
CSW01_06290	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
CSW01_06340	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CSW01_06345	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CSW01_06350	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CSW01_06370	COG2814	Major facilitator Superfamily
CSW01_06380	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CSW01_06405	COG2989	Protein conserved in bacteria
CSW01_06410	COG3108	Peptidase M15
CSW01_06415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CSW01_06430	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CSW01_06460	COG1846	Transcriptional regulator
CSW01_06465	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CSW01_06470	COG0726	polysaccharide deacetylase
CSW01_06475	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CSW01_06485	COG1447	Phosphotransferase system cellobiose-specific component IIA
CSW01_06490	COG1486	melibiose metabolic process
CSW01_06495	COG3394	polysaccharide catabolic process
CSW01_06500	COG1609	Transcriptional regulator
CSW01_06505	COG2943	transferase activity, transferring hexosyl groups
CSW01_06510	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CSW01_06515	COG0840	transmembrane signaling receptor activity
CSW01_06530	COG1448	Aminotransferase
CSW01_06540	COG2770	Histidine kinase
CSW01_06540	COG3437	response regulator, receiver
CSW01_06545	COG0351	phosphomethylpyrimidine kinase
CSW01_06550	COG0017	Asparaginyl-tRNA synthetase
CSW01_06560	COG0720	synthase
CSW01_06565	COG1760	l-serine dehydratase
CSW01_06570	COG0814	amino acid
CSW01_06575	COG0494	nUDIX hydrolase
CSW01_06580	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CSW01_06595	COG3106	COG3106 Predicted ATPase
CSW01_06600	COG3768	UPF0283 membrane protein
CSW01_06605	COG3283	Transcriptional regulator of aromatic amino acids metabolism
CSW01_06610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CSW01_06625	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CSW01_06635	COG0471	metal ion transport
CSW01_06640	COG4191	Histidine kinase
CSW01_06640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CSW01_06650	COG2990	Protein conserved in bacteria
CSW01_06655	COG3713	MltA-interacting MipA family protein
CSW01_06660	COG2205	protein histidine kinase activity
CSW01_06665	COG0745	RESPONSE REGULATOR receiver
CSW01_06695	COG1129	ABC transporter
CSW01_06730	COG2186	Transcriptional regulator
CSW01_06735	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CSW01_06740	COG0372	Belongs to the citrate synthase family
CSW01_06770	COG2195	Cleaves the N-terminal amino acid of tripeptides
CSW01_06780	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CSW01_06790	COG0625	glutathione transferase activity
CSW01_06795	COG3437	response regulator, receiver
CSW01_06815	COG3706	GGDEF domain
CSW01_06820	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CSW01_06825	COG1254	Belongs to the acylphosphatase family
CSW01_06830	COG2920	part of a sulfur-relay system
CSW01_06835	COG0670	Belongs to the BI1 family
CSW01_06840	COG1126	abc transporter atp-binding protein
CSW01_06845	COG0765	amino acid transport
CSW01_06850	COG4597	amino acid ABC transporter
CSW01_06855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CSW01_06865	COG0561	phosphatase activity
CSW01_06870	COG0602	queuosine metabolic process
CSW01_06875	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CSW01_06905	COG3706	GGDEF domain
CSW01_06910	COG0443	Heat shock 70 kDa protein
CSW01_06915	COG0443	Heat shock 70 kDa protein
CSW01_06950	COG1643	Atp-dependent helicase
CSW01_06960	COG0443	Heat shock 70 kDa protein
CSW01_06965	COG0095	Lipoate-protein ligase
CSW01_06975	COG0583	DNA-binding transcription factor activity
CSW01_06980	COG0477	Major facilitator Superfamily
CSW01_06985	COG0415	Belongs to the DNA photolyase family
CSW01_06990	COG2076	Multidrug Resistance protein
CSW01_07010	COG0643	Histidine kinase
CSW01_07010	COG2198	Histidine kinase
CSW01_07030	COG2201	protein-glutamate methylesterase activity
CSW01_07035	COG0835	chemotaxis
CSW01_07040	COG3290	protein histidine kinase activity
CSW01_07040	COG0840	transmembrane signaling receptor activity
CSW01_07045	COG0840	transmembrane signaling receptor activity
CSW01_07055	COG0513	Belongs to the DEAD box helicase family
CSW01_07065	COG1538	Outer membrane efflux protein
CSW01_07070	COG1566	PFAM secretion protein HlyD family protein
CSW01_07075	COG2814	Major facilitator Superfamily
CSW01_07080	COG0840	transmembrane signaling receptor activity
CSW01_07085	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CSW01_07095	COG3501	Rhs element vgr protein
CSW01_07120	COG1280	lysine exporter protein (LysE YggA)
CSW01_07125	COG1115	amino acid carrier protein
CSW01_07140	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CSW01_07145	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CSW01_07150	COG1177	transmembrane transport
CSW01_07155	COG1176	ABC-type spermidine putrescine transport system, permease component I
CSW01_07160	COG3842	ATPase activity
CSW01_07180	COG0037	tRNA processing
CSW01_07185	COG0589	response to stress
CSW01_07190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CSW01_07205	COG2217	Heavy metal translocating P-type atpase
CSW01_07215	COG2010	Cytochrome c
CSW01_07230	COG3278	Belongs to the heme-copper respiratory oxidase family
CSW01_07245	COG0784	Response regulator, receiver
CSW01_07245	COG2205	protein histidine kinase activity
CSW01_07270	COG2994	toxin metabolic process
CSW01_07275	COG3064	Membrane
CSW01_07275	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CSW01_07275	COG1073	alpha beta
CSW01_07295	COG1476	TRANSCRIPTIONal
CSW01_07315	COG4128	Pfam Zonular occludens toxin
CSW01_07345	COG1476	TRANSCRIPTIONal
CSW01_07445	COG3120	sequence-specific DNA binding
CSW01_07450	COG1067	ATP-dependent peptidase activity
CSW01_07455	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CSW01_07480	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CSW01_07480	COG0116	Belongs to the methyltransferase superfamily
CSW01_07490	COG0167	dihydroorotate dehydrogenase activity
CSW01_07505	COG0308	aminopeptidase N
CSW01_07520	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
CSW01_07525	COG1956	GAF domain-containing protein
CSW01_07530	COG1132	(ABC) transporter
CSW01_07535	COG2995	paraquat-inducible protein a
CSW01_07540	COG3008	intermembrane lipid transfer
CSW01_07545	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CSW01_07545	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CSW01_07550	COG2996	Protein conserved in bacteria
CSW01_07565	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CSW01_07575	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CSW01_07590	COG0437	4 iron, 4 sulfur cluster binding
CSW01_07595	COG3383	formate dehydrogenase (NAD+) activity
CSW01_07595	COG0243	molybdopterin cofactor binding
CSW01_07625	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CSW01_07630	COG0488	(ABC) transporter
CSW01_07635	COG3852	Histidine kinase
CSW01_07640	COG2204	response regulator
CSW01_07650	COG4662	Binding-protein-dependent transport system inner membrane component
CSW01_07655	COG3842	ATPase activity
CSW01_07660	COG0746	molybdenum cofactor guanylyltransferase activity
CSW01_07695	COG1940	carbohydrate kinase activity
CSW01_07710	COG0840	transmembrane signaling receptor activity
CSW01_07715	COG0791	NLP P60 protein
CSW01_07735	COG0534	Mate efflux family protein
CSW01_07745	COG1793	dna ligase
CSW01_07760	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CSW01_07765	COG0848	biopolymer transport protein
CSW01_07770	COG0811	peptide transport
CSW01_07775	COG0811	peptide transport
CSW01_07790	COG1175	transmembrane transport
CSW01_07795	COG0395	ABC-type sugar transport system, permease component
CSW01_07800	COG3842	ATPase activity
CSW01_07805	COG1349	DNA-binding transcription factor activity
CSW01_07810	COG0584	glycerophosphoryl diester phosphodiesterase
CSW01_07815	COG2731	YhcH YjgK YiaL family protein
CSW01_07820	COG0251	oxidation-reduction process
CSW01_07825	COG1609	Transcriptional regulator
CSW01_07830	COG2723	6-phospho-beta-galactosidase activity
CSW01_07835	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CSW01_07840	COG0583	DNA-binding transcription factor activity
CSW01_07860	COG0577	efflux transmembrane transporter activity
CSW01_07860	COG1136	(ABC) transporter
CSW01_07865	COG0577	efflux transmembrane transporter activity
CSW01_07865	COG1136	(ABC) transporter
CSW01_07870	COG4591	ABC-type transport system involved in lipoprotein release permease component
CSW01_07870	COG1136	(ABC) transporter
CSW01_07875	COG1294	oxidase, subunit
CSW01_07880	COG1271	oxidase subunit
CSW01_07925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CSW01_07935	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CSW01_07955	COG0753	catalase activity
CSW01_07970	COG3527	Alpha-acetolactate decarboxylase
CSW01_07985	COG2200	EAL domain
CSW01_07985	COG2199	diguanylate cyclase activity
CSW01_07990	COG3706	GGDEF domain
CSW01_07995	COG2017	converts alpha-aldose to the beta-anomer
CSW01_08000	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CSW01_08005	COG1085	galactose-1-phosphate uridylyltransferase
CSW01_08030	COG3706	GGDEF domain
CSW01_08030	COG0745	RESPONSE REGULATOR receiver
CSW01_08050	COG0784	Response regulator, receiver
CSW01_08050	COG0835	chemotaxis
CSW01_08060	COG4565	transcriptional regulatory protein
CSW01_08065	COG3290	protein histidine kinase activity
CSW01_08080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CSW01_08100	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CSW01_08105	COG3063	Type IV pilus biogenesis stability protein PilW
CSW01_08115	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CSW01_08120	COG1451	nucleotide metabolic process
CSW01_08130	COG0583	DNA-binding transcription factor activity
CSW01_08150	COG1538	Outer membrane efflux protein
CSW01_08160	COG0019	diaminopimelate decarboxylase activity
CSW01_08165	COG1748	Saccharopine dehydrogenase
CSW01_08180	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CSW01_08195	COG4181	ATPase activity
CSW01_08200	COG0534	Mate efflux family protein
CSW01_08205	COG0702	epimerase
CSW01_08215	COG2814	Major facilitator Superfamily
CSW01_08220	COG1187	pseudouridine synthase activity
CSW01_08225	COG1061	Type III restriction enzyme res subunit
CSW01_08245	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CSW01_08250	COG2203	Gaf domain
CSW01_08250	COG3706	GGDEF domain
CSW01_08250	COG4251	negative regulation of phosphorylation
CSW01_08250	COG5001	Diguanylate cyclase
CSW01_08265	COG0840	transmembrane signaling receptor activity
CSW01_08295	COG4934	collagen metabolic process
CSW01_08315	COG2239	Acts as a magnesium transporter
CSW01_08325	COG0814	amino acid
CSW01_08330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CSW01_08335	COG1131	(ABC) transporter
CSW01_08340	COG0842	Transport permease protein
CSW01_08350	COG3313	Fe-S protein
CSW01_08360	COG4134	Bacterial extracellular solute-binding protein
CSW01_08365	COG4135	transport system, permease component
CSW01_08370	COG4136	ATPase activity
CSW01_08375	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CSW01_08380	COG0564	pseudouridine synthase activity
CSW01_08385	COG0733	neurotransmitter:sodium symporter activity
CSW01_08400	COG0626	cystathionine gamma-synthase activity
CSW01_08405	COG2818	Glycosylase
CSW01_08420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CSW01_08435	COG1842	Phage shock protein A
CSW01_08440	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CSW01_08450	COG4168	peptide transport system, permease
CSW01_08455	COG4171	peptide transport system, permease
CSW01_08465	COG4172	Belongs to the ABC transporter superfamily
CSW01_08480	COG1227	inorganic diphosphatase activity
CSW01_08505	COG0243	molybdopterin cofactor binding
CSW01_08510	COG3005	denitrification pathway
CSW01_08515	COG4459	periplasmic nitrate reductase
CSW01_08525	COG2116	formate transmembrane transporter activity
CSW01_08540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CSW01_08545	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CSW01_08555	COG2917	probably involved in intracellular septation
CSW01_08560	COG1607	acyl-coa hydrolase
CSW01_08565	COG2350	Protein conserved in bacteria
CSW01_08575	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CSW01_08580	COG0583	DNA-binding transcription factor activity
CSW01_08595	COG0612	Peptidase, M16
CSW01_08605	COG1032	radical SAM domain protein
CSW01_08620	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CSW01_08625	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CSW01_08630	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
CSW01_08635	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CSW01_08640	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CSW01_08645	COG0745	RESPONSE REGULATOR receiver
CSW01_08650	COG3381	protein complex oligomerization
CSW01_08660	COG1609	Transcriptional regulator
CSW01_08665	COG3070	regulator of competence-specific genes
CSW01_08685	COG0297	glycogen (starch) synthase activity
CSW01_08690	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CSW01_08695	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CSW01_08705	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CSW01_08715	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CSW01_08720	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CSW01_08725	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CSW01_08735	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CSW01_08760	COG1012	belongs to the aldehyde dehydrogenase family
CSW01_08765	COG1309	transcriptional regulator
CSW01_08790	COG0668	transmembrane transport
CSW01_08795	COG2995	paraquat-inducible protein a
CSW01_08800	COG3008	intermembrane lipid transfer
CSW01_08800	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CSW01_08810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CSW01_08825	COG0582	viral genome integration into host DNA
CSW01_08830	COG0582	viral genome integration into host DNA
CSW01_08835	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CSW01_08855	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CSW01_08875	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CSW01_08895	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
CSW01_08900	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
CSW01_08905	COG1737	Transcriptional regulator
CSW01_08910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CSW01_08915	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CSW01_08920	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CSW01_08925	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CSW01_08935	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CSW01_08940	COG1940	carbohydrate kinase activity
CSW01_08945	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CSW01_08950	COG4409	exo-alpha-(2->6)-sialidase activity
CSW01_08960	COG2003	Belongs to the UPF0758 family
CSW01_08975	COG3941	tape measure
CSW01_09020	COG0488	(ABC) transporter
CSW01_09100	COG0415	Belongs to the DNA photolyase family
CSW01_09110	COG4628	conserved protein (DUF2132)
CSW01_09115	COG3284	Transcriptional regulator
CSW01_09120	COG1012	belongs to the aldehyde dehydrogenase family
CSW01_09130	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CSW01_09135	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CSW01_09140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CSW01_09150	COG2207	Transcriptional regulator
CSW01_09155	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CSW01_09155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CSW01_09155	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CSW01_09160	COG1482	cell wall glycoprotein biosynthetic process
CSW01_09170	COG0784	Response regulator, receiver
CSW01_09170	COG5002	protein histidine kinase activity
CSW01_09180	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CSW01_09190	COG2885	chlorophyll binding
CSW01_09195	COG0823	Involved in the tonB-independent uptake of proteins
CSW01_09210	COG0811	peptide transport
CSW01_09215	COG0824	Thioesterase
CSW01_09220	COG3790	cyd operon protein YbgE
CSW01_09225	COG4890	Cyd operon protein YbgT
CSW01_09230	COG1294	oxidase, subunit
CSW01_09235	COG1271	oxidase subunit
CSW01_09240	COG2255	four-way junction helicase activity
CSW01_09245	COG0632	four-way junction helicase activity
CSW01_09250	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CSW01_09255	COG0215	cysteine-tRNA ligase activity
CSW01_09260	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CSW01_09270	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CSW01_09280	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
CSW01_09285	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CSW01_09290	COG1199	ATP-dependent helicase activity
CSW01_09295	COG0730	response to heat
CSW01_09300	COG3923	Primosomal replication protein n
CSW01_09310	COG0840	transmembrane signaling receptor activity
CSW01_09315	COG0708	Exodeoxyribonuclease III
CSW01_09320	COG4160	amino acid transport
CSW01_09325	COG4215	(ABC) transporter
CSW01_09350	COG1882	Formate acetyltransferase
CSW01_09360	COG0840	transmembrane signaling receptor activity
CSW01_09365	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CSW01_09375	COG3013	Belongs to the UPF0304 family
CSW01_09380	COG2766	serine protein kinase
CSW01_09385	COG2718	Belongs to the UPF0229 family
CSW01_09390	COG2719	SpoVR family
CSW01_09395	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CSW01_09405	COG1663	tetraacyldisaccharide 4'-kinase activity
CSW01_09410	COG1132	(ABC) transporter
CSW01_09415	COG0658	competence protein
CSW01_09415	COG2333	competence protein COMEC
CSW01_09425	COG4591	ABC-type transport system involved in lipoprotein release permease component
CSW01_09430	COG1136	(ABC) transporter
CSW01_09435	COG4591	ABC-type transport system involved in lipoprotein release permease component
CSW01_09445	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CSW01_09465	COG1252	NADH dehydrogenase
CSW01_09495	COG0537	adenosine 5'-monophosphoramidase activity
CSW01_09510	COG2186	Transcriptional regulator
CSW01_09515	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CSW01_09520	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CSW01_09525	COG1674	ftsk spoiiie
CSW01_09535	COG0686	Belongs to the AlaDH PNT family
CSW01_09545	COG0583	DNA-binding transcription factor activity
CSW01_09560	COG0284	orotidine-5'-phosphate decarboxylase activity
CSW01_09565	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CSW01_09570	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CSW01_09575	COG0776	regulation of translation
CSW01_09580	COG0539	negative regulation of cytoplasmic translation
CSW01_09585	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CSW01_09590	COG1555	photosystem II stabilization
CSW01_09595	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CSW01_09600	COG0776	regulation of translation
CSW01_09605	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CSW01_09610	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CSW01_09620	COG0544	peptidyl-prolyl cis-trans isomerase activity
CSW01_09630	COG4191	Histidine kinase
CSW01_09640	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CSW01_09645	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CSW01_09650	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CSW01_09655	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CSW01_09670	COG5001	Diguanylate cyclase
CSW01_09670	COG3300	MHYT domain
CSW01_09680	COG4589	Belongs to the CDS family
CSW01_09720	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CSW01_09730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CSW01_09750	COG0243	molybdopterin cofactor binding
CSW01_09755	COG3005	denitrification pathway
CSW01_09760	COG3325	Belongs to the glycosyl hydrolase 18 family
CSW01_09760	COG3469	chitinase activity
CSW01_09765	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CSW01_09775	COG2951	lytic endotransglycosylase activity
CSW01_09780	COG3100	YcgL domain-containing protein
CSW01_09785	COG0850	regulation of cytokinetic process
CSW01_09790	COG2894	cell division
CSW01_09795	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CSW01_09800	COG3015	lipoprotein NlpE involved in copper resistance
CSW01_09820	COG0477	Major facilitator Superfamily
CSW01_09825	COG0840	transmembrane signaling receptor activity
CSW01_09830	COG1396	sequence-specific DNA binding
CSW01_09835	COG3135	benzoate transporter
CSW01_09845	COG1441	menaquinone biosynthetic process
CSW01_09855	COG0596	Alpha beta hydrolase
CSW01_09860	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CSW01_09865	COG1169	isochorismate synthase
CSW01_09870	COG0436	Aminotransferase
CSW01_09875	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CSW01_09880	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CSW01_09900	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CSW01_09905	COG0318	PFAM AMP-dependent synthetase and ligase
CSW01_09910	COG0596	Alpha beta hydrolase
CSW01_09925	COG1214	PFAM Peptidase M22, glycoprotease
CSW01_09930	COG1199	ATP-dependent helicase activity
CSW01_09940	COG0788	formyltetrahydrofolate deformylase activity
CSW01_09945	COG0446	pyridine nucleotide-disulphide oxidoreductase
CSW01_09945	COG1902	pentaerythritol trinitrate reductase activity
CSW01_09950	COG0616	signal peptide processing
CSW01_09955	COG0252	asparaginase activity
CSW01_09960	COG3139	Protein of unknown function (DUF1315)
CSW01_09970	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CSW01_09975	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CSW01_09980	COG0676	glucose-6-phosphate 1-epimerase activity
CSW01_10000	COG2226	methyltransferase
CSW01_10015	COG0784	Response regulator, receiver
CSW01_10015	COG0835	chemotaxis
CSW01_10020	COG1940	carbohydrate kinase activity
CSW01_10030	COG4667	esterase of the alpha-beta hydrolase superfamily
CSW01_10045	COG0733	neurotransmitter:sodium symporter activity
CSW01_10055	COG1263	PTS System
CSW01_10055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CSW01_10060	COG0084	hydrolase, TatD family'
CSW01_10070	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CSW01_10075	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CSW01_10080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CSW01_10085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CSW01_10090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CSW01_10095	COG1028	Short-chain dehydrogenase reductase Sdr
CSW01_10100	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CSW01_10105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CSW01_10110	COG0416	fatty acid biosynthetic process
CSW01_10115	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CSW01_10120	COG1399	metal-binding, possibly nucleic acid-binding protein
CSW01_10125	COG0424	maF-like protein
CSW01_10130	COG0564	pseudouridine synthase activity
CSW01_10145	COG1530	ribonuclease E activity
CSW01_10150	COG0659	secondary active sulfate transmembrane transporter activity
CSW01_10165	COG1454	alcohol dehydrogenase
CSW01_10165	COG1012	belongs to the aldehyde dehydrogenase family
CSW01_10170	COG2095	MarC family integral membrane protein
CSW01_10175	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CSW01_10180	COG1757	Na H antiporter
CSW01_10190	COG3081	Nucleoid-associated protein
CSW01_10200	COG3083	sulfuric ester hydrolase activity
CSW01_10215	COG0123	including yeast histone deacetylase and acetoin utilization protein
CSW01_10220	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CSW01_10225	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CSW01_10245	COG2853	Lipoprotein
CSW01_10255	COG3088	subunit of a heme lyase
CSW01_10255	COG4235	cytochrome complex assembly
CSW01_10260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CSW01_10265	COG1138	Cytochrome C-type biogenesis protein
CSW01_10270	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CSW01_10280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CSW01_10285	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CSW01_10290	COG4133	protoheme IX ABC transporter activity
CSW01_10300	COG0835	chemotaxis
CSW01_10310	COG1192	Involved in chromosome partitioning
CSW01_10315	COG2201	protein-glutamate methylesterase activity
CSW01_10320	COG2198	Histidine kinase
CSW01_10320	COG0643	Histidine kinase
CSW01_10325	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CSW01_10340	COG0455	bacterial-type flagellum organization
CSW01_10355	COG2062	phosphohistidine phosphatase, SixA
CSW01_10360	COG1025	Belongs to the peptidase M16 family
CSW01_10370	COG0018	arginyl-trna synthetase
CSW01_10390	COG1918	ferrous iron import across plasma membrane
CSW01_10395	COG4977	sequence-specific DNA binding
CSW01_10400	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CSW01_10405	COG1121	(ABC) transporter
CSW01_10410	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CSW01_10420	COG0045	succinate-CoA ligase (ADP-forming) activity
CSW01_10425	COG0508	dehydrogenase complex catalyzes the overall conversion of
CSW01_10430	COG0567	Dehydrogenase, E1 component
CSW01_10440	COG1053	succinate dehydrogenase
CSW01_10445	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CSW01_10450	COG2009	succinate dehydrogenase
CSW01_10455	COG0372	Belongs to the citrate synthase family
CSW01_10460	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CSW01_10470	COG0033	Phosphoglucomutase
CSW01_10475	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CSW01_10480	COG0596	Alpha beta hydrolase
CSW01_10495	COG1346	cytolysis
CSW01_10505	COG0583	DNA-binding transcription factor activity
CSW01_10515	COG0735	belongs to the Fur family
CSW01_10520	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CSW01_10525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CSW01_10530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CSW01_10535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CSW01_10535	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CSW01_10540	COG0431	NADPH-dependent FMN reductase
CSW01_10550	COG3101	peptidyl-lysine hydroxylation
CSW01_10555	COG2860	membrane
CSW01_10560	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CSW01_10570	COG2890	protein-(glutamine-N5) methyltransferase activity
CSW01_10585	COG1684	flagellar biosynthetic protein fliR
CSW01_10590	COG1987	bacterial-type flagellum assembly
CSW01_10615	COG1580	Controls the rotational direction of flagella during chemotaxis
CSW01_10640	COG1317	bacterial-type flagellum organization
CSW01_10645	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CSW01_10655	COG1677	Flagellar hook-basal body complex protein FliE
CSW01_10660	COG2204	response regulator
CSW01_10665	COG4191	Histidine kinase
CSW01_10670	COG2204	response regulator
CSW01_10675	COG1516	flagellar protein fliS
CSW01_10685	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CSW01_10690	COG1334	flagellar protein FlaG
CSW01_10695	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CSW01_10700	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CSW01_10705	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CSW01_10710	COG2837	iron assimilation
CSW01_10730	COG1393	Belongs to the ArsC family
CSW01_10735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CSW01_10740	COG1876	peptidase activity
CSW01_10750	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CSW01_10755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CSW01_10765	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CSW01_10770	COG0840	transmembrane signaling receptor activity
CSW01_10785	COG4783	chaperone-mediated protein folding
CSW01_10790	COG1393	Belongs to the ArsC family
CSW01_10810	COG2233	PERMEase
CSW01_10815	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CSW01_10820	COG0737	Belongs to the 5'-nucleotidase family
CSW01_10825	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CSW01_10830	COG2912	Transglutaminase-like superfamily
CSW01_10835	COG3094	Invasion gene expression up-regulator, SirB
CSW01_10840	COG2890	protein-(glutamine-N5) methyltransferase activity
CSW01_10845	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CSW01_10850	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CSW01_10855	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CSW01_10860	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CSW01_10865	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CSW01_10870	COG0193	aminoacyl-tRNA hydrolase activity
CSW01_10875	COG0012	GTP binding
CSW01_10940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CSW01_11070	COG4695	Portal protein
CSW01_11165	COG4974	Belongs to the 'phage' integrase family
CSW01_11170	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CSW01_11185	COG3951	Flagellar rod assembly protein muramidase FlgJ
CSW01_11185	COG1705	Flagellar rod assembly protein muramidase FlgJ
CSW01_11190	COG1706	bacterial-type flagellum-dependent cell motility
CSW01_11195	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CSW01_11200	COG4786	Flagellar basal body rod
CSW01_11205	COG4787	bacterial-type flagellum-dependent cell motility
CSW01_11210	COG1749	Flagellar hook protein flgE
CSW01_11215	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CSW01_11220	COG1558	bacterial-type flagellum-dependent cell motility
CSW01_11225	COG1815	bacterial-type flagellum-dependent cell motility
CSW01_11230	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CSW01_11235	COG0784	Response regulator, receiver
CSW01_11235	COG0835	chemotaxis
CSW01_11270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CSW01_11270	COG2226	methyltransferase
CSW01_11270	COG3433	isochorismatase activity
CSW01_11275	COG2375	cellular response to nickel ion
CSW01_11280	COG4774	siderophore transport
CSW01_11280	COG1629	transport
CSW01_11295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CSW01_11300	COG2217	Heavy metal translocating P-type atpase
CSW01_11300	COG2608	mercury ion transmembrane transporter activity
CSW01_11315	COG3735	TraB family
CSW01_11330	COG2840	Smr protein MutS2
CSW01_11335	COG1187	pseudouridine synthase activity
CSW01_11340	COG3706	GGDEF domain
CSW01_11345	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CSW01_11350	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CSW01_11355	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CSW01_11360	COG0121	glutamine amidotransferase
CSW01_11365	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CSW01_11370	COG1960	acyl-CoA dehydrogenase activity
CSW01_11380	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CSW01_11385	COG0328	RNA-DNA hybrid ribonuclease activity
CSW01_11390	COG2226	methyltransferase
CSW01_11395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CSW01_11400	COG1388	LysM domain
CSW01_11400	COG0741	lytic transglycosylase activity
CSW01_11410	COG0347	Belongs to the P(II) protein family
CSW01_11415	COG3479	Phenolic acid decarboxylase
CSW01_11425	COG0037	tRNA processing
CSW01_11430	COG0825	malonyl-CoA metabolic process
CSW01_11435	COG0587	DNA-directed DNA polymerase activity
CSW01_11440	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CSW01_11445	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CSW01_11450	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CSW01_11455	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CSW01_11460	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CSW01_11465	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CSW01_11475	COG0750	zinc metalloprotease
CSW01_11480	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CSW01_11485	COG0575	Belongs to the CDS family
CSW01_11490	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CSW01_11495	COG0233	cytoplasmic translational termination
CSW01_11500	COG0528	UMP kinase activity
CSW01_11505	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CSW01_11510	COG0052	Belongs to the universal ribosomal protein uS2 family
CSW01_11515	COG0024	Methionine aminopeptidase
CSW01_11520	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CSW01_11530	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CSW01_11535	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CSW01_11540	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CSW01_11545	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CSW01_11560	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CSW01_11560	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CSW01_11565	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CSW01_11570	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CSW01_11575	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CSW01_11590	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CSW01_11595	COG2252	PERMEase
CSW01_11600	COG2195	Cleaves the N-terminal amino acid of tripeptides
CSW01_11605	COG4067	protein conserved in archaea
CSW01_11605	COG0189	ligase activity
CSW01_11610	COG0189	ligase activity
CSW01_11620	COG0733	neurotransmitter:sodium symporter activity
CSW01_11625	COG3706	GGDEF domain
CSW01_11635	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CSW01_11645	COG1477	protein flavinylation
CSW01_11650	COG2871	sodium ion transport
CSW01_11655	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CSW01_11660	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CSW01_11665	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CSW01_11670	COG1805	sodium ion transport
CSW01_11675	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CSW01_11680	COG0271	Belongs to the BolA IbaG family
CSW01_11685	COG2813	Specifically methylates the guanine in position
CSW01_11695	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CSW01_11705	COG2211	Major facilitator Superfamily
CSW01_11715	COG1595	DNA-templated transcription, initiation
CSW01_11725	COG3248	Nucleoside-binding outer membrane protein
CSW01_11730	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CSW01_11735	COG0693	protein deglycase activity
CSW01_11740	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CSW01_11745	COG2166	iron-sulfur cluster assembly
CSW01_11750	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CSW01_11755	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CSW01_11765	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CSW01_11765	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CSW01_11775	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CSW01_11780	COG1074	ATP-dependent DNA helicase activity
CSW01_11785	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CSW01_11800	COG3141	response to X-ray
CSW01_11805	COG2171	N-acyltransferase activity
CSW01_11815	COG0456	acetyltransferase
CSW01_11820	COG0189	ligase activity
CSW01_11820	COG0569	domain protein
CSW01_11835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CSW01_11840	COG1609	Transcriptional regulator
CSW01_11845	COG3250	beta-galactosidase activity
CSW01_11860	COG1022	Amp-dependent synthetase and ligase
CSW01_11865	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CSW01_11870	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CSW01_11885	COG0560	Phosphoserine phosphatase
CSW01_11895	COG0813	purine-nucleoside phosphorylase activity
CSW01_11900	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CSW01_11905	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CSW01_11910	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CSW01_11920	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CSW01_11925	COG0084	hydrolase, TatD family'
CSW01_11935	COG1115	amino acid carrier protein
CSW01_11950	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CSW01_11955	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CSW01_11960	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
CSW01_11965	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CSW01_11970	COG0083	homoserine kinase activity
CSW01_11990	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CSW01_12000	COG0745	RESPONSE REGULATOR receiver
CSW01_12005	COG2198	Histidine kinase
CSW01_12005	COG5002	protein histidine kinase activity
CSW01_12005	COG0784	Response regulator, receiver
CSW01_12010	COG5001	Diguanylate cyclase
CSW01_12010	COG3706	GGDEF domain
CSW01_12010	COG4251	negative regulation of phosphorylation
CSW01_12010	COG2203	Gaf domain
CSW01_12015	COG1242	4 iron, 4 sulfur cluster binding
CSW01_12020	COG0067	glutamate synthase
CSW01_12020	COG0069	glutamate synthase activity
CSW01_12020	COG0070	glutamate synthase
CSW01_12030	COG0070	glutamate synthase
CSW01_12030	COG0067	glutamate synthase
CSW01_12030	COG0069	glutamate synthase activity
CSW01_12035	COG0493	'glutamate synthase
CSW01_12045	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CSW01_12055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CSW01_12060	COG2860	membrane
CSW01_12065	COG0583	DNA-binding transcription factor activity
CSW01_12070	COG0730	response to heat
CSW01_12080	COG4172	Belongs to the ABC transporter superfamily
CSW01_12100	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CSW01_12105	COG0505	Belongs to the CarA family
CSW01_12115	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CSW01_12120	COG0494	nUDIX hydrolase
CSW01_12125	COG0653	protein targeting
CSW01_12135	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CSW01_12140	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CSW01_12145	COG0849	cell division
CSW01_12150	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CSW01_12155	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CSW01_12160	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CSW01_12165	COG0772	Belongs to the SEDS family
CSW01_12170	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CSW01_12175	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CSW01_12180	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CSW01_12185	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CSW01_12190	COG0768	penicillin binding
CSW01_12195	COG3116	cell division
CSW01_12200	COG0275	rRNA processing
CSW01_12210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CSW01_12215	COG0508	dehydrogenase complex catalyzes the overall conversion of
CSW01_12220	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CSW01_12225	COG2186	Transcriptional regulator
CSW01_12235	COG0737	Belongs to the 5'-nucleotidase family
CSW01_12240	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CSW01_12245	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CSW01_12250	COG4974	Belongs to the 'phage' integrase family
CSW01_12255	COG0716	FMN binding
CSW01_12275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CSW01_12280	COG1459	type II secretion system
CSW01_12290	COG0237	dephospho-CoA kinase activity
CSW01_12295	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CSW01_12300	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CSW01_12305	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CSW01_12310	COG0187	DNA topoisomerase II activity
CSW01_12315	COG3150	esterase
CSW01_12325	COG3151	Protein conserved in bacteria
CSW01_12330	COG0494	nUDIX hydrolase
CSW01_12335	COG1538	Outer membrane efflux protein
CSW01_12345	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CSW01_12350	COG0840	transmembrane signaling receptor activity
CSW01_12355	COG3025	triphosphatase activity
CSW01_12360	COG1392	Phosphate transport regulator
CSW01_12365	COG0306	phosphate transporter
CSW01_12370	COG4991	sh3 domain protein
CSW01_12380	COG3409	Peptidoglycan-binding domain 1 protein
CSW01_12380	COG3267	Type II secretory pathway component ExeA
CSW01_12385	COG0617	tRNA 3'-terminal CCA addition
CSW01_12390	COG0148	phosphopyruvate hydratase activity
CSW01_12395	COG0504	CTP synthase activity
CSW01_12400	COG3956	TIGRFAM MazG family protein
CSW01_12405	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CSW01_12410	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CSW01_12420	COG5001	Diguanylate cyclase
CSW01_12435	COG0736	holo-[acyl-carrier-protein] synthase activity
CSW01_12440	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CSW01_12445	COG1381	Involved in DNA repair and RecF pathway recombination
CSW01_12450	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CSW01_12455	COG0571	ribonuclease III activity
CSW01_12460	COG0681	Belongs to the peptidase S26 family
CSW01_12465	COG0481	GTPase activity
CSW01_12470	COG3086	response to oxidative stress
CSW01_12475	COG3026	antisigma factor binding
CSW01_12485	COG1595	DNA-templated transcription, initiation
CSW01_12495	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CSW01_12505	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CSW01_12510	COG0354	folic acid binding
CSW01_12520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CSW01_12525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CSW01_12535	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CSW01_12545	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CSW01_12550	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CSW01_12555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CSW01_12560	COG0440	acetolactate synthase activity
CSW01_12565	COG0028	Belongs to the TPP enzyme family
CSW01_12570	COG1022	Amp-dependent synthetase and ligase
CSW01_12575	COG0583	DNA-binding transcription factor activity
CSW01_12595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CSW01_12600	COG0473	3-isopropylmalate dehydrogenase activity
CSW01_12605	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CSW01_12610	COG0066	3-isopropylmalate dehydratase activity
CSW01_12655	COG3437	response regulator, receiver
CSW01_12670	COG0795	lipopolysaccharide-transporting ATPase activity
CSW01_12675	COG0795	lipopolysaccharide-transporting ATPase activity
CSW01_12680	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CSW01_12685	COG2927	DNA polymerase III (CHI subunit)
CSW01_12690	COG0525	valine-tRNA ligase activity
CSW01_12695	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CSW01_12700	COG0564	pseudouridine synthase activity
CSW01_12705	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CSW01_12715	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CSW01_12720	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CSW01_12725	COG0540	Belongs to the ATCase OTCase family
CSW01_12730	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CSW01_12735	COG0251	oxidation-reduction process
CSW01_12740	COG0204	Acyl-transferase
CSW01_12745	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CSW01_12750	COG5007	Belongs to the BolA IbaG family
CSW01_12760	COG2854	intermembrane phospholipid transfer
CSW01_12765	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CSW01_12770	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CSW01_12775	COG1127	ABC transporter
CSW01_12790	COG0517	IMP dehydrogenase activity
CSW01_12790	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CSW01_12805	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CSW01_12810	COG1137	ATPase activity
CSW01_12820	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CSW01_12825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CSW01_12830	COG1660	Displays ATPase and GTPase activities
CSW01_12835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CSW01_12840	COG2239	Acts as a magnesium transporter
CSW01_12845	COG0312	modulator of DNA gyrase
CSW01_12850	COG3028	Belongs to the UPF0307 family
CSW01_12855	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CSW01_12860	COG1178	ABC-type Fe3 transport system permease component
CSW01_12865	COG4143	(ABC) transporter
CSW01_12870	COG0163	prenyltransferase activity
CSW01_12875	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CSW01_12885	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CSW01_12890	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CSW01_12895	COG2105	PFAM AIG2 family protein
CSW01_12905	COG0729	surface antigen
CSW01_12910	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CSW01_12915	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CSW01_12930	COG1136	(ABC) transporter
CSW01_12950	COG0529	Catalyzes the synthesis of activated sulfate
CSW01_12955	COG2895	sulfate adenylyltransferase (ATP) activity
CSW01_12960	COG0175	sulfate reduction
CSW01_12965	COG1648	precorrin-2 dehydrogenase activity
CSW01_12965	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CSW01_12970	COG0737	Belongs to the 5'-nucleotidase family
CSW01_12980	COG0513	Belongs to the DEAD box helicase family
CSW01_12985	COG2153	protein acetylation
CSW01_12990	COG0697	spore germination
CSW01_12995	COG3266	domain, Protein
CSW01_12995	COG3061	Opacity-associated protein A
CSW01_13000	COG0545	Peptidyl-prolyl cis-trans isomerase
CSW01_13010	COG0203	ribosomal protein L17
CSW01_13015	COG0202	RNA polymerase activity
CSW01_13020	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CSW01_13025	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CSW01_13030	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CSW01_13040	COG0201	protein transport
CSW01_13045	COG0200	Binds to the 23S rRNA
CSW01_13050	COG1841	ribosomal large subunit assembly
CSW01_13055	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CSW01_13060	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CSW01_13065	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CSW01_13070	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CSW01_13075	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CSW01_13080	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CSW01_13085	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CSW01_13090	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CSW01_13095	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CSW01_13100	COG0255	Belongs to the universal ribosomal protein uL29 family
CSW01_13105	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CSW01_13110	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CSW01_13115	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CSW01_13120	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CSW01_13125	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CSW01_13130	COG0089	rRNA binding
CSW01_13135	COG0088	Forms part of the polypeptide exit tunnel
CSW01_13140	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CSW01_13145	COG0051	transcription antitermination factor activity, RNA binding
CSW01_13150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CSW01_13155	COG0557	exoribonuclease II activity
CSW01_13160	COG3083	sulfuric ester hydrolase activity
CSW01_13165	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CSW01_13175	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CSW01_13185	COG1047	Peptidyl-prolyl cis-trans
CSW01_13200	COG2249	NAD(P)H dehydrogenase (quinone) activity
CSW01_13205	COG0488	(ABC) transporter
CSW01_13215	COG0429	hydrolase of the alpha beta-hydrolase fold
CSW01_13225	COG3954	Phosphoribulokinase
CSW01_13230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CSW01_13240	COG1012	belongs to the aldehyde dehydrogenase family
CSW01_13250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CSW01_13260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CSW01_13275	COG0180	Tryptophanyl-tRNA synthetase
CSW01_13280	COG0546	phosphoglycolate phosphatase activity
CSW01_13285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CSW01_13290	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CSW01_13300	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CSW01_13305	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CSW01_13335	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CSW01_13345	COG0678	peroxiredoxin activity
CSW01_13345	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CSW01_13350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CSW01_13360	COG0165	Argininosuccinate lyase
CSW01_13370	COG0137	argininosuccinate synthase activity
CSW01_13375	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CSW01_13380	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CSW01_13385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CSW01_13390	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CSW01_13400	COG1045	serine acetyltransferase
CSW01_13405	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CSW01_13410	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CSW01_13415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CSW01_13420	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CSW01_13425	COG1053	succinate dehydrogenase
CSW01_13430	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CSW01_13435	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CSW01_13440	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CSW01_13445	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CSW01_13450	COG1509	lysine 2,3-aminomutase activity
CSW01_13460	COG0459	protein refolding
CSW01_13465	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CSW01_13490	COG0149	triose-phosphate isomerase activity
CSW01_13500	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CSW01_13505	COG1575	Belongs to the MenA family. Type 1 subfamily
CSW01_13510	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CSW01_13515	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CSW01_13520	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CSW01_13525	COG1609	Transcriptional regulator
CSW01_13530	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CSW01_13535	COG0254	rRNA binding
CSW01_13540	COG0281	malic enzyme
CSW01_13545	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
CSW01_13550	COG0626	cystathionine gamma-synthase activity
CSW01_13555	COG0527	aspartate kinase activity
CSW01_13555	COG0460	homoserine dehydrogenase
CSW01_13560	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CSW01_13565	COG3074	FtsZ-dependent cytokinesis
CSW01_13570	COG1494	fructose-1,6-bisphosphatase
CSW01_13575	COG0205	6-phosphofructokinase activity
CSW01_13580	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CSW01_13590	COG0745	RESPONSE REGULATOR receiver
CSW01_13595	COG2205	protein histidine kinase activity
CSW01_13605	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CSW01_13610	COG3030	protein affecting phage T7 exclusion by the F plasmid
CSW01_13615	COG3706	GGDEF domain
CSW01_13620	COG1027	Aspartate ammonia-lyase
CSW01_13625	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CSW01_13635	COG4232	protein-disulfide reductase activity
CSW01_13645	COG3263	regulation of cellular component size
CSW01_13655	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CSW01_13660	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CSW01_13665	COG0194	GDP metabolic process
CSW01_13670	COG1758	RNA polymerase activity
CSW01_13675	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CSW01_13680	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CSW01_13685	COG2233	PERMEase
CSW01_13695	COG0745	RESPONSE REGULATOR receiver
CSW01_13700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CSW01_13705	COG2183	response to ionizing radiation
CSW01_13715	COG0596	Alpha beta hydrolase
CSW01_13720	COG1040	competence protein
CSW01_13725	COG0316	Belongs to the HesB IscA family
CSW01_13725	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CSW01_13730	COG0494	nUDIX hydrolase
CSW01_13735	COG1218	3'(2'),5'-bisphosphate nucleotidase
CSW01_13745	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
CSW01_13750	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
CSW01_13755	COG3156	type II secretion system protein K
CSW01_13760	COG4795	General secretion pathway protein
CSW01_13765	COG2165	general secretion pathway protein
CSW01_13770	COG2165	general secretion pathway protein
CSW01_13775	COG2165	general secretion pathway protein
CSW01_13780	COG1459	type II secretion system
CSW01_13785	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CSW01_13795	COG3031	protein transport across the cell outer membrane
CSW01_13800	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CSW01_13805	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CSW01_13810	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CSW01_13820	COG0456	acetyltransferase
CSW01_13825	COG1490	D-aminoacyl-tRNA deacylase activity
CSW01_13835	COG1660	Displays ATPase and GTPase activities
CSW01_13850	COG0174	glutamine synthetase
CSW01_13860	COG3852	Histidine kinase
CSW01_13870	COG3300	MHYT domain
CSW01_13870	COG5001	Diguanylate cyclase
CSW01_13875	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CSW01_13955	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
CSW01_13960	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CSW01_13965	COG1739	Uncharacterized protein family UPF0029
CSW01_13970	COG1024	Enoyl-CoA hydratase
CSW01_13970	COG1250	3-hydroxyacyl-CoA dehydrogenase
CSW01_13975	COG0183	Belongs to the thiolase family
CSW01_13980	COG0583	DNA-binding transcription factor activity
CSW01_13985	COG2814	Major facilitator Superfamily
CSW01_13990	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CSW01_13995	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CSW01_14000	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CSW01_14005	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CSW01_14010	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CSW01_14015	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CSW01_14020	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CSW01_14030	COG0356	it plays a direct role in the translocation of protons across the membrane
CSW01_14035	COG3312	ion transport
CSW01_14040	COG1475	DNA binding
CSW01_14045	COG1192	Involved in chromosome partitioning
CSW01_14050	COG0357	Ribosomal RNA small subunit methyltransferase G
CSW01_14055	COG0445	tRNA wobble uridine modification
CSW01_14085	COG0217	transcriptional regulatory protein
CSW01_14090	COG2084	Dehydrogenase
CSW01_14110	COG2909	trisaccharide binding
CSW01_14115	COG0058	SHG alpha-glucan phosphorylase activity
CSW01_14120	COG1640	4-alpha-glucanotransferase
CSW01_14125	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CSW01_14140	COG3501	Rhs element vgr protein
CSW01_14175	COG0471	metal ion transport
CSW01_14180	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
CSW01_14225	COG0671	phosphoesterase, PA-phosphatase related
CSW01_14230	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CSW01_14240	COG1999	signal sequence binding
CSW01_14255	COG0786	glutamate:sodium symporter activity
CSW01_14275	COG1566	PFAM secretion protein HlyD family protein
CSW01_14285	COG3706	GGDEF domain
CSW01_14300	COG0813	purine-nucleoside phosphorylase activity
CSW01_14310	COG3272	Protein of unknown function (DUF1722)
CSW01_14320	COG0415	Belongs to the DNA photolyase family
CSW01_14325	COG1388	LysM domain
CSW01_14325	COG1376	ErfK ybiS ycfS ynhG family protein
CSW01_14335	COG0513	Belongs to the DEAD box helicase family
CSW01_14340	COG1770	oligopeptidase
CSW01_14370	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CSW01_14375	COG0573	inorganic phosphate transmembrane transporter activity
CSW01_14380	COG0581	inorganic phosphate transmembrane transporter activity
CSW01_14385	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CSW01_14410	COG0659	secondary active sulfate transmembrane transporter activity
CSW01_14420	COG0739	heme binding
CSW01_14425	COG5001	Diguanylate cyclase
CSW01_14425	COG3300	MHYT domain
CSW01_14430	COG0583	DNA-binding transcription factor activity
CSW01_14435	COG2814	Major facilitator Superfamily
CSW01_14470	COG1342	Belongs to the UPF0251 family
CSW01_14505	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CSW01_14510	COG0673	inositol 2-dehydrogenase activity
CSW01_14520	COG2771	luxR family
CSW01_14520	COG2200	EAL domain
CSW01_14525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CSW01_14535	COG0564	pseudouridine synthase activity
CSW01_14630	COG3501	Rhs element vgr protein
CSW01_14645	COG1869	D-ribose catabolic process
CSW01_14650	COG1129	ABC transporter
CSW01_14655	COG1172	Belongs to the binding-protein-dependent transport system permease family
CSW01_14660	COG1879	ABC-type sugar transport system periplasmic component
CSW01_14665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CSW01_14670	COG1609	Transcriptional regulator
CSW01_14680	COG3201	nicotinamide mononucleotide transporter
CSW01_14685	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CSW01_14695	COG0584	glycerophosphoryl diester phosphodiesterase
CSW01_14700	COG2271	Major facilitator Superfamily
CSW01_14740	COG0579	oxidoreductase
CSW01_14750	COG0242	peptide deformylase activity
CSW01_14760	COG1320	monovalent cation:proton antiporter activity
CSW01_14765	COG2212	antiporter activity
CSW01_14785	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CSW01_14785	COG2111	Na H antiporter
CSW01_14795	COG0589	response to stress
CSW01_14800	COG0814	amino acid
CSW01_14805	COG3033	Beta-eliminating lyase
CSW01_14815	COG3530	Putative quorum-sensing-regulated virulence factor
CSW01_14825	COG5002	protein histidine kinase activity
CSW01_14825	COG5001	Diguanylate cyclase
CSW01_14830	COG1278	Cold shock
CSW01_14845	COG2304	oxidoreductase activity
CSW01_14865	COG0714	Associated with various cellular activities
CSW01_14870	COG0840	transmembrane signaling receptor activity
CSW01_14885	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CSW01_14890	COG2195	Cleaves the N-terminal amino acid of tripeptides
CSW01_14900	COG3604	Transcriptional regulator
CSW01_14905	COG1017	nitric oxide dioxygenase activity
CSW01_14905	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CSW01_14910	COG1278	Cold shock
CSW01_14915	COG3036	rescue of stalled ribosome
CSW01_14940	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CSW01_14940	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CSW01_14945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CSW01_14955	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CSW01_14970	COG0516	GMP reductase activity
CSW01_14995	COG1943	Transposase
CSW01_15010	COG0513	Belongs to the DEAD box helicase family
CSW01_15015	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CSW01_15020	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CSW01_15025	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CSW01_15035	COG0784	Response regulator, receiver
CSW01_15035	COG3437	response regulator, receiver
CSW01_15040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CSW01_15040	COG4191	Histidine kinase
CSW01_15050	COG1757	Na H antiporter
CSW01_15055	COG2814	Major facilitator Superfamily
CSW01_15065	COG3706	GGDEF domain
CSW01_15070	COG3240	lipase activity
CSW01_15080	COG0840	transmembrane signaling receptor activity
CSW01_15085	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CSW01_15090	COG5380	lipid catabolic process
CSW01_15095	COG4412	M6 family metalloprotease domain protein
CSW01_15095	COG3291	Pkd domain containing protein
CSW01_15115	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CSW01_15120	COG4605	iron ion homeostasis
CSW01_15125	COG4604	ABC transporter, ATP-binding protein
CSW01_15145	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CSW01_15165	COG0745	RESPONSE REGULATOR receiver
CSW01_15175	COG3623	hexulose-6-phosphate isomerase
CSW01_15180	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CSW01_15185	COG0561	phosphatase activity
CSW01_15215	COG3038	cytochrome b561
CSW01_15220	COG0366	Alpha amylase catalytic
CSW01_15240	COG0745	RESPONSE REGULATOR receiver
CSW01_15245	COG5002	protein histidine kinase activity
CSW01_15270	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CSW01_15285	COG2814	Major facilitator Superfamily
CSW01_15300	COG1686	Belongs to the peptidase S11 family
CSW01_15320	COG1943	Transposase
CSW01_15330	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CSW01_15330	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CSW01_15335	COG0509	glycine decarboxylation via glycine cleavage system
CSW01_15340	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CSW01_15350	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CSW01_15360	COG3039	Transposase
CSW01_15385	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CSW01_15395	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CSW01_15400	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CSW01_15470	COG1028	Short-chain dehydrogenase reductase Sdr
CSW01_15510	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CSW01_15535	COG0494	nUDIX hydrolase
CSW01_15555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CSW01_15560	COG3040	lipid binding
CSW01_15605	COG3041	Addiction module toxin RelE StbE family
CSW01_15720	COG1619	proteins homologs of microcin C7 resistance protein MccF
CSW01_15790	COG0346	lactoylglutathione lyase activity
CSW01_15805	COG3040	lipid binding
CSW01_15825	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CSW01_15835	COG1280	lysine exporter protein (LysE YggA)
CSW01_16040	COG3549	Plasmid maintenance system killer
CSW01_16045	COG3093	addiction module antidote protein HigA
CSW01_16070	COG0384	phenazine biosynthesis protein PhzF
CSW01_16110	COG0346	lactoylglutathione lyase activity
CSW01_16155	COG3040	lipid binding
CSW01_16220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CSW01_16250	COG0384	phenazine biosynthesis protein PhzF
CSW01_16365	COG1619	proteins homologs of microcin C7 resistance protein MccF
CSW01_16390	COG3040	lipid binding
CSW01_16455	COG4977	sequence-specific DNA binding
CSW01_16560	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
CSW01_16565	COG2944	sequence-specific DNA binding
CSW01_16580	COG3039	Transposase
CSW01_16585	COG0110	maltose O-acetyltransferase activity
CSW01_16605	COG0346	lactoylglutathione lyase activity
CSW01_16715	COG1943	Transposase
CSW01_16780	COG0346	lactoylglutathione lyase activity
CSW01_16800	COG1328	CTP reductase activity
CSW01_16805	COG0602	queuosine metabolic process
CSW01_16815	COG4067	protein conserved in archaea
CSW01_16815	COG0189	ligase activity
CSW01_16820	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CSW01_16820	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CSW01_16820	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CSW01_16825	COG1105	Belongs to the carbohydrate kinase PfkB family
CSW01_16830	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CSW01_16830	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CSW01_16835	COG1609	Transcriptional regulator
CSW01_16840	COG0420	3'-5' exonuclease activity
CSW01_16845	COG0419	ATPase involved in DNA repair
CSW01_16850	COG0784	Response regulator, receiver
CSW01_16850	COG2205	protein histidine kinase activity
CSW01_16855	COG0156	8-amino-7-oxononanoate synthase activity
CSW01_16865	COG0038	chloride channel
CSW01_16870	COG0523	cobalamin synthesis protein
CSW01_16880	COG3158	transport of potassium into the cell
CSW01_16885	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CSW01_16885	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CSW01_16885	COG1013	pyruvate-flavodoxin oxidoreductase activity
CSW01_16885	COG0674	pyruvate-flavodoxin oxidoreductase activity
CSW01_16890	COG2205	protein histidine kinase activity
CSW01_16895	COG0745	RESPONSE REGULATOR receiver
CSW01_16900	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CSW01_16905	COG0586	Pfam SNARE associated Golgi protein
CSW01_16915	COG2200	EAL domain
CSW01_16925	COG3038	cytochrome b561
CSW01_16935	COG2116	formate transmembrane transporter activity
CSW01_16940	COG0583	DNA-binding transcription factor activity
CSW01_16950	COG3593	DNA synthesis involved in DNA repair
CSW01_16955	COG0737	Belongs to the 5'-nucleotidase family
CSW01_16970	COG2824	Alkylphosphonate utilization operon protein PhnA
CSW01_17025	COG3706	GGDEF domain
CSW01_17040	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CSW01_17045	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CSW01_17055	COG0745	RESPONSE REGULATOR receiver
CSW01_17075	COG0023	Translation Initiation Factor
CSW01_17085	COG1181	Belongs to the D-alanine--D-alanine ligase family
CSW01_17095	COG0045	succinate-CoA ligase (ADP-forming) activity
CSW01_17095	COG1042	CoA-binding domain protein
CSW01_17095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CSW01_17100	COG0583	DNA-binding transcription factor activity
CSW01_17105	COG4771	TonB-dependent receptor
CSW01_17105	COG1629	transport
CSW01_17125	COG2050	protein possibly involved in aromatic compounds catabolism
CSW01_17150	COG0625	glutathione transferase activity
CSW01_17165	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CSW01_17170	COG4172	Belongs to the ABC transporter superfamily
CSW01_17175	COG4239	(ABC) transporter, permease
CSW01_17180	COG4174	ABC transporter (Permease)
CSW01_17185	COG4166	transmembrane transport
CSW01_17230	COG3842	ATPase activity
CSW01_17240	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CSW01_17250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CSW01_17255	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CSW01_17260	COG1011	Hydrolase
CSW01_17270	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CSW01_17275	COG1970	mechanosensitive ion channel activity
CSW01_17280	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CSW01_17285	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CSW01_17285	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CSW01_17290	COG0302	gtp cyclohydrolase
CSW01_17300	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CSW01_17310	COG2897	thiosulfate sulfurtransferase activity
CSW01_17315	COG2390	Transcriptional regulator
CSW01_17325	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CSW01_17330	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CSW01_17355	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CSW01_17380	COG0583	DNA-binding transcription factor activity
CSW01_17385	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CSW01_17390	COG0778	Nitroreductase
CSW01_17420	COG0640	Transcriptional regulator
CSW01_17430	COG0446	pyridine nucleotide-disulphide oxidoreductase
CSW01_17475	COG1263	PTS System
CSW01_17475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CSW01_17485	COG1621	beta-fructofuranosidase activity
CSW01_17490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CSW01_17495	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CSW01_17505	COG2885	chlorophyll binding
CSW01_17510	COG0545	Peptidyl-prolyl cis-trans isomerase
CSW01_17515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CSW01_17520	COG0840	transmembrane signaling receptor activity
CSW01_17530	COG3069	C4-dicarboxylate transmembrane transporter activity
CSW01_17535	COG1760	l-serine dehydratase
CSW01_17555	COG1609	Transcriptional regulator
CSW01_17560	COG2197	response regulator
CSW01_17565	COG3850	Histidine kinase
CSW01_17570	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CSW01_17580	COG0243	molybdopterin cofactor binding
CSW01_17600	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CSW01_17605	COG2197	response regulator
CSW01_17610	COG3851	Histidine kinase
CSW01_17615	COG2271	Major facilitator Superfamily
CSW01_17620	COG1840	ABC-type Fe3 transport system, periplasmic component
CSW01_17630	COG3842	ATPase activity
CSW01_17635	COG3243	poly(R)-hydroxyalkanoic acid synthase
CSW01_17645	COG0183	Belongs to the thiolase family
CSW01_17655	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CSW01_17660	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CSW01_17675	COG3706	GGDEF domain
CSW01_17680	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CSW01_17690	COG1979	alcohol dehydrogenase
CSW01_17705	COG4191	Histidine kinase
CSW01_17710	COG1840	ABC-type Fe3 transport system, periplasmic component
CSW01_17715	COG2271	Major facilitator Superfamily
CSW01_17720	COG0469	pyruvate kinase activity
CSW01_17725	COG0784	Response regulator, receiver
CSW01_17725	COG2198	Histidine kinase
CSW01_17725	COG2205	protein histidine kinase activity
CSW01_17730	COG1879	ABC-type sugar transport system periplasmic component
CSW01_17735	COG1803	Methylglyoxal synthase
CSW01_17740	COG1335	isochorismatase
CSW01_17745	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CSW01_17760	COG0210	DNA helicase
CSW01_17765	COG1289	transmembrane transporter activity
CSW01_17795	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CSW01_17800	COG4149	molybdate abc transporter
CSW01_17805	COG0725	ABC transporter, periplasmic molybdate-binding protein
CSW01_17810	COG1492	cobalamin metabolic process
CSW01_17855	COG0784	Response regulator, receiver
CSW01_17855	COG5002	protein histidine kinase activity
CSW01_17860	COG1879	ABC-type sugar transport system periplasmic component
CSW01_17870	COG2827	Endonuclease containing a URI domain
CSW01_17900	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CSW01_17905	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CSW01_17910	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CSW01_17915	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
CSW01_17920	COG0247	lactate metabolic process
CSW01_17925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CSW01_17930	COG3118	belongs to the thioredoxin family
CSW01_17960	COG0583	DNA-binding transcription factor activity
CSW01_17965	COG4160	amino acid transport
CSW01_17970	COG4215	(ABC) transporter
CSW01_17975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CSW01_17980	COG1126	abc transporter atp-binding protein
CSW01_17990	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CSW01_18000	COG0494	nUDIX hydrolase
CSW01_18005	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CSW01_18015	COG1309	transcriptional regulator
CSW01_18020	COG0513	Belongs to the DEAD box helicase family
CSW01_18025	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
CSW01_18035	COG0814	amino acid
CSW01_18040	COG0840	transmembrane signaling receptor activity
CSW01_18045	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CSW01_18055	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CSW01_18065	COG1984	allophanate hydrolase subunit 2
CSW01_18080	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CSW01_18085	COG4181	ATPase activity
CSW01_18095	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CSW01_18100	COG1716	ATPase activity
CSW01_18100	COG5001	Diguanylate cyclase
CSW01_18115	COG0484	heat shock protein binding
CSW01_18155	COG0546	phosphoglycolate phosphatase activity
CSW01_18170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CSW01_18175	COG1368	sulfuric ester hydrolase activity
CSW01_18185	COG0513	Belongs to the DEAD box helicase family
CSW01_18190	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
CSW01_18200	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CSW01_18210	COG3046	protein related to deoxyribodipyrimidine photolyase
CSW01_18215	COG3397	chitin binding
CSW01_18220	COG3227	Zinc metalloprotease (Elastase)
CSW01_18230	COG0010	Belongs to the arginase family
CSW01_18235	COG1166	arginine decarboxylase activity
CSW01_18250	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CSW01_18255	COG0459	protein refolding
CSW01_18265	COG0527	aspartate kinase activity
CSW01_18270	COG0662	Cupin 2, conserved barrel domain protein
CSW01_18275	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CSW01_18280	COG0456	acetyltransferase
CSW01_18285	COG2154	pterin-4-alpha-carbinolamine dehydratase
CSW01_18290	COG3186	Phenylalanine-4-hydroxylase
CSW01_18315	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CSW01_18320	COG0583	DNA-binding transcription factor activity
CSW01_18335	COG2171	N-acyltransferase activity
CSW01_18340	COG1253	flavin adenine dinucleotide binding
CSW01_18345	COG1765	OsmC-like protein
CSW01_18370	COG0531	amino acid
CSW01_18375	COG3706	GGDEF domain
CSW01_18385	COG3279	Response regulator of the LytR AlgR family
CSW01_18390	COG3275	phosphorelay sensor kinase activity
CSW01_18405	COG1136	(ABC) transporter
CSW01_18405	COG0577	efflux transmembrane transporter activity
CSW01_18410	COG1136	(ABC) transporter
CSW01_18425	COG4989	oxidoreductase activity
CSW01_18430	COG0366	Alpha amylase catalytic
CSW01_18440	COG2067	long-chain fatty acid transport protein
CSW01_18445	COG2267	carboxylic ester hydrolase activity
CSW01_18455	COG3227	Zinc metalloprotease (Elastase)
CSW01_18465	COG3047	cAMP biosynthetic process
CSW01_18475	COG1686	Belongs to the peptidase S11 family
CSW01_18480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CSW01_18485	COG1271	oxidase subunit
CSW01_18490	COG1294	oxidase, subunit
CSW01_18510	COG3048	D-serine ammonia-lyase activity
CSW01_18515	COG0583	DNA-binding transcription factor activity
CSW01_18565	COG1063	alcohol dehydrogenase
CSW01_18595	COG0346	lactoylglutathione lyase activity
CSW01_18615	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CSW01_18620	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CSW01_18625	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CSW01_18630	COG0363	glucosamine-6-phosphate deaminase activity
CSW01_18635	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CSW01_18660	COG1929	Belongs to the glycerate kinase type-1 family
CSW01_18665	COG2610	gluconate transmembrane transporter activity
CSW01_18670	COG3835	regulator
CSW01_18680	COG0748	coenzyme F420 binding
CSW01_18685	COG3721	Heme iron utilization protein
CSW01_18695	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CSW01_18700	COG0811	peptide transport
CSW01_18705	COG0848	biopolymer transport protein
CSW01_18710	COG4558	Periplasmic binding protein
CSW01_18715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CSW01_18720	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CSW01_18755	COG3217	Mosc domain protein beta barrel domain protein
CSW01_18755	COG0633	Ferredoxin
CSW01_18755	COG3217	Mosc domain protein beta barrel domain protein
CSW01_18755	COG0633	Ferredoxin
CSW01_18760	COG0418	dihydroorotase activity
CSW01_18770	COG3152	Membrane
CSW01_18780	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CSW01_18785	COG2354	Protein conserved in bacteria
CSW01_18790	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CSW01_18795	COG1278	Cold shock
CSW01_18825	COG3706	GGDEF domain
CSW01_18830	COG1349	DNA-binding transcription factor activity
CSW01_18845	COG3833	ABC-type maltose transport systems, permease component
CSW01_18850	COG1175	transmembrane transport
CSW01_18860	COG3842	ATPase activity
CSW01_18865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CSW01_18880	COG0393	Putative heavy-metal-binding
CSW01_18885	COG2197	response regulator
CSW01_18890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CSW01_18895	COG0784	Response regulator, receiver
CSW01_18895	COG0835	chemotaxis
CSW01_18900	COG1846	Transcriptional regulator
CSW01_18905	COG3706	GGDEF domain
CSW01_18945	COG0583	DNA-binding transcription factor activity
CSW01_18950	COG5001	Diguanylate cyclase
CSW01_18960	COG1741	Belongs to the pirin family
CSW01_18965	COG3123	guanosine phosphorylase activity
CSW01_18975	COG2211	Major facilitator Superfamily
CSW01_18985	COG0840	transmembrane signaling receptor activity
CSW01_18990	COG1067	ATP-dependent peptidase activity
CSW01_19000	COG4172	Belongs to the ABC transporter superfamily
CSW01_19025	COG0583	DNA-binding transcription factor activity
CSW01_19030	COG1620	l-lactate permease
CSW01_19035	COG1304	FMN binding
CSW01_19045	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CSW01_19055	COG0840	transmembrane signaling receptor activity
CSW01_19065	COG0513	Belongs to the DEAD box helicase family
CSW01_19070	COG0583	DNA-binding transcription factor activity
CSW01_19080	COG1902	pentaerythritol trinitrate reductase activity
CSW01_19090	COG1132	(ABC) transporter
CSW01_19100	COG1902	pentaerythritol trinitrate reductase activity
CSW01_19110	COG1280	lysine exporter protein (LysE YggA)
CSW01_19115	COG2207	Transcriptional regulator
CSW01_19135	COG1846	Transcriptional regulator
CSW01_19140	COG1764	response to oxidative stress
CSW01_19145	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CSW01_19150	COG0697	spore germination
CSW01_19160	COG0700	Nucleoside recognition
CSW01_19165	COG3366	ferrous iron transmembrane transporter activity
CSW01_19170	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CSW01_19180	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CSW01_19185	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CSW01_19190	COG2259	Doxx family
CSW01_19215	COG0363	glucosamine-6-phosphate deaminase activity
CSW01_19230	COG4580	involved in the transport of maltose and maltodextrins
CSW01_19245	COG0840	transmembrane signaling receptor activity
CSW01_19260	COG0840	transmembrane signaling receptor activity
CSW01_19270	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CSW01_19275	COG1126	abc transporter atp-binding protein
CSW01_19285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CSW01_19290	COG4597	amino acid ABC transporter
CSW01_19295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CSW01_19305	COG0739	heme binding
CSW01_19315	COG2213	PTS system mannitol-specific
CSW01_19315	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CSW01_19320	COG0246	Mannitol dehydrogenase
CSW01_19325	COG3722	fumarate hydratase activity
CSW01_19330	COG0673	inositol 2-dehydrogenase activity
CSW01_19360	COG2910	NAD(P)H-binding
CSW01_19370	COG0840	transmembrane signaling receptor activity
CSW01_19375	COG4221	oxidoreductase activity
CSW01_19385	COG1901	pseudouridine methyltransferase
CSW01_19390	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CSW01_19400	COG0531	amino acid
CSW01_19405	COG1982	Orn Lys Arg decarboxylase major
CSW01_19440	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CSW01_19465	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CSW01_19475	COG0259	pyridoxamine-phosphate oxidase activity
CSW01_19505	COG0745	RESPONSE REGULATOR receiver
CSW01_19525	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CSW01_19530	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CSW01_19535	COG0840	transmembrane signaling receptor activity
CSW01_19540	COG0835	chemotaxis
CSW01_19545	COG0835	chemotaxis
CSW01_19550	COG0643	Histidine kinase
CSW01_19550	COG2198	Histidine kinase
CSW01_19570	COG0601	transmembrane transport
CSW01_19575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CSW01_19585	COG2194	sulfuric ester hydrolase activity
CSW01_19590	COG0642	Histidine kinase
CSW01_19595	COG0745	RESPONSE REGULATOR receiver
CSW01_19625	COG1444	tRNA N-acetyltransferase activity
CSW01_19630	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine