locus-tag	class	description
HPY10_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPY10_00010	COG0592	DNA-directed DNA polymerase activity
HPY10_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPY10_00020	COG0187	DNA topoisomerase II activity
HPY10_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
HPY10_00035	COG3977	Valine--pyruvate aminotransferase
HPY10_00040	COG0751	glycine-tRNA ligase activity
HPY10_00045	COG0752	glycyl-tRNA synthetase alpha subunit
HPY10_00050	COG2119	membrane
HPY10_00060	COG0425	Belongs to the sulfur carrier protein TusA family
HPY10_00070	COG0604	alcohol dehydrogenase
HPY10_00080	COG0129	dihydroxy-acid dehydratase activity
HPY10_00085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY10_00100	COG0606	chelatase, subunit chli
HPY10_00105	COG0204	Acyl-transferase
HPY10_00110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY10_00115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPY10_00125	COG3084	Protein conserved in bacteria
HPY10_00130	COG4326	sporulation control protein
HPY10_00135	COG1272	protein, Hemolysin III
HPY10_00145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY10_00150	COG0569	domain protein
HPY10_00155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY10_00155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPY10_00160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPY10_00165	COG0242	peptide deformylase activity
HPY10_00170	COG1652	LysM domain
HPY10_00175	COG0758	DNA mediated transformation
HPY10_00180	COG2922	Belongs to the Smg family
HPY10_00185	COG0551	DNA topoisomerase type I activity
HPY10_00190	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPY10_00195	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPY10_00200	COG0009	L-threonylcarbamoyladenylate synthase
HPY10_00205	COG0408	coproporphyrinogen oxidase activity
HPY10_00210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPY10_00220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPY10_00260	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPY10_00265	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HPY10_00275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY10_00280	COG2104	thiamine diphosphate biosynthetic process
HPY10_00285	COG2022	thiamine diphosphate biosynthetic process
HPY10_00290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY10_00295	COG0006	proline dipeptidase activity
HPY10_00295	COG0006	proline dipeptidase activity
HPY10_00315	COG1522	sequence-specific DNA binding
HPY10_00320	COG5001	Diguanylate cyclase
HPY10_00320	COG5002	protein histidine kinase activity
HPY10_00345	COG0589	response to stress
HPY10_00350	COG1528	Iron-storage protein
HPY10_00360	COG2081	HI0933 family
HPY10_00370	COG1322	Protein conserved in bacteria
HPY10_00375	COG2226	methyltransferase
HPY10_00390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY10_00395	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY10_00400	COG0805	protein transport
HPY10_00405	COG0534	Mate efflux family protein
HPY10_00415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPY10_00420	COG2937	Belongs to the GPAT DAPAT family
HPY10_00425	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HPY10_00430	COG3161	chorismate lyase activity
HPY10_00435	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY10_00440	COG0840	transmembrane signaling receptor activity
HPY10_00450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY10_00455	COG0084	hydrolase, TatD family'
HPY10_00470	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY10_00470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY10_00490	COG3078	GTPase activator activity
HPY10_00505	COG3071	HemY protein
HPY10_00510	COG2959	enzyme of heme biosynthesis
HPY10_00515	COG1587	Uroporphyrinogen-III synthase
HPY10_00520	COG0181	hydroxymethylbilane synthase activity
HPY10_00530	COG1965	Belongs to the frataxin family
HPY10_00540	COG0019	diaminopimelate decarboxylase activity
HPY10_00545	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPY10_00555	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HPY10_00560	COG1011	Hydrolase
HPY10_00565	COG2200	EAL domain
HPY10_00565	COG3287	FIST C domain
HPY10_00565	COG2199	diguanylate cyclase activity
HPY10_00580	COG0561	phosphatase activity
HPY10_00585	COG2267	carboxylic ester hydrolase activity
HPY10_00590	COG1280	lysine exporter protein (LysE YggA)
HPY10_00595	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY10_00600	COG0783	Belongs to the Dps family
HPY10_00630	COG0742	ribosomal rna small subunit methyltransferase
HPY10_00635	COG0552	protein localization to endoplasmic reticulum
HPY10_00640	COG2884	Cell division ATP-binding protein ftsE
HPY10_00645	COG2177	Part of the ABC transporter FtsEX involved in
HPY10_00650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY10_00655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY10_00670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY10_00680	COG1404	Belongs to the peptidase S8 family
HPY10_00685	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPY10_00750	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HPY10_00755	COG5001	Diguanylate cyclase
HPY10_00755	COG3300	MHYT domain
HPY10_00765	COG3852	Histidine kinase
HPY10_00775	COG0174	glutamine synthetase
HPY10_00795	COG1295	ribonuclease BN
HPY10_00800	COG1490	D-aminoacyl-tRNA deacylase activity
HPY10_00805	COG0456	acetyltransferase
HPY10_00815	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HPY10_00820	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HPY10_00825	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPY10_00830	COG3031	protein transport across the cell outer membrane
HPY10_00840	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY10_00845	COG1459	type II secretion system
HPY10_00850	COG2165	general secretion pathway protein
HPY10_00855	COG2165	general secretion pathway protein
HPY10_00860	COG2165	general secretion pathway protein
HPY10_00865	COG4795	General secretion pathway protein
HPY10_00870	COG3156	type II secretion system protein K
HPY10_00875	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY10_00880	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY10_00890	COG1218	3'(2'),5'-bisphosphate nucleotidase
HPY10_00895	COG0494	nUDIX hydrolase
HPY10_00905	COG1040	competence protein
HPY10_00915	COG0596	Alpha beta hydrolase
HPY10_00925	COG2183	response to ionizing radiation
HPY10_00965	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY10_00970	COG2199	diguanylate cyclase activity
HPY10_00975	COG0745	RESPONSE REGULATOR receiver
HPY10_00985	COG2233	PERMEase
HPY10_00990	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPY10_00995	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY10_01000	COG1758	RNA polymerase activity
HPY10_01005	COG0194	GDP metabolic process
HPY10_01010	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HPY10_01015	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY10_01035	COG4232	protein-disulfide reductase activity
HPY10_01045	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY10_01050	COG1027	Aspartate ammonia-lyase
HPY10_01055	COG3706	GGDEF domain
HPY10_01060	COG3030	protein affecting phage T7 exclusion by the F plasmid
HPY10_01065	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPY10_01075	COG2205	protein histidine kinase activity
HPY10_01080	COG0745	RESPONSE REGULATOR receiver
HPY10_01090	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPY10_01095	COG0205	6-phosphofructokinase activity
HPY10_01100	COG1494	fructose-1,6-bisphosphatase
HPY10_01105	COG3074	FtsZ-dependent cytokinesis
HPY10_01110	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPY10_01115	COG0460	homoserine dehydrogenase
HPY10_01115	COG0527	aspartate kinase activity
HPY10_01120	COG0626	cystathionine gamma-synthase activity
HPY10_01125	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HPY10_01130	COG0281	malic enzyme
HPY10_01135	COG0254	rRNA binding
HPY10_01140	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPY10_01145	COG1609	Transcriptional regulator
HPY10_01150	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY10_01155	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPY10_01160	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPY10_01165	COG1575	Belongs to the MenA family. Type 1 subfamily
HPY10_01170	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY10_01175	COG0534	Mate efflux family protein
HPY10_01180	COG0149	triose-phosphate isomerase activity
HPY10_01205	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPY10_01210	COG0459	protein refolding
HPY10_01220	COG1509	lysine 2,3-aminomutase activity
HPY10_01225	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY10_01235	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HPY10_01240	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPY10_01245	COG1053	succinate dehydrogenase
HPY10_01250	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HPY10_01255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY10_01260	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HPY10_01265	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPY10_01270	COG1045	serine acetyltransferase
HPY10_01280	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HPY10_01285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPY10_01290	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPY10_01295	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY10_01300	COG0137	argininosuccinate synthase activity
HPY10_01305	COG0165	Argininosuccinate lyase
HPY10_01315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY10_01320	COG0678	peroxiredoxin activity
HPY10_01320	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY10_01330	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPY10_01360	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPY10_01365	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPY10_01375	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HPY10_01380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPY10_01385	COG0546	phosphoglycolate phosphatase activity
HPY10_01390	COG0180	Tryptophanyl-tRNA synthetase
HPY10_01410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY10_01420	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPY10_01430	COG1012	belongs to the aldehyde dehydrogenase family
HPY10_01445	COG3954	Phosphoribulokinase
HPY10_01455	COG0429	hydrolase of the alpha beta-hydrolase fold
HPY10_01465	COG0488	(ABC) transporter
HPY10_01470	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPY10_01485	COG1047	Peptidyl-prolyl cis-trans
HPY10_01495	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY10_01500	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPY10_01505	COG3083	sulfuric ester hydrolase activity
HPY10_01510	COG0557	exoribonuclease II activity
HPY10_01515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY10_01520	COG0051	transcription antitermination factor activity, RNA binding
HPY10_01525	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPY10_01530	COG0088	Forms part of the polypeptide exit tunnel
HPY10_01535	COG0089	rRNA binding
HPY10_01540	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPY10_01545	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HPY10_01550	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPY10_01555	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HPY10_01560	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HPY10_01565	COG0255	Belongs to the universal ribosomal protein uL29 family
HPY10_01570	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPY10_01575	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPY10_01580	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HPY10_01585	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPY10_01590	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPY10_01595	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HPY10_01600	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HPY10_01605	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPY10_01610	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HPY10_01615	COG1841	ribosomal large subunit assembly
HPY10_01625	COG0201	protein transport
HPY10_01630	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY10_01635	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPY10_01640	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HPY10_01645	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPY10_01650	COG0202	RNA polymerase activity
HPY10_01655	COG0203	ribosomal protein L17
HPY10_01665	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY10_01670	COG3266	domain, Protein
HPY10_01670	COG3061	Opacity-associated protein A
HPY10_01675	COG0697	spore germination
HPY10_01680	COG2153	protein acetylation
HPY10_01685	COG0513	Belongs to the DEAD box helicase family
HPY10_01695	COG0737	Belongs to the 5'-nucleotidase family
HPY10_01700	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPY10_01700	COG1648	precorrin-2 dehydrogenase activity
HPY10_01705	COG0175	sulfate reduction
HPY10_01710	COG2895	sulfate adenylyltransferase (ATP) activity
HPY10_01715	COG0529	Catalyzes the synthesis of activated sulfate
HPY10_01735	COG1136	(ABC) transporter
HPY10_01750	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HPY10_01755	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY10_01760	COG0729	surface antigen
HPY10_01770	COG2105	PFAM AIG2 family protein
HPY10_01775	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPY10_01785	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY10_01790	COG0163	prenyltransferase activity
HPY10_01800	COG1178	ABC-type Fe3 transport system permease component
HPY10_01805	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HPY10_01810	COG3028	Belongs to the UPF0307 family
HPY10_01815	COG0312	modulator of DNA gyrase
HPY10_01820	COG2239	Acts as a magnesium transporter
HPY10_01825	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY10_01830	COG1660	Displays ATPase and GTPase activities
HPY10_01835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY10_01840	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY10_01850	COG1137	ATPase activity
HPY10_01855	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HPY10_01870	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPY10_01870	COG0517	IMP dehydrogenase activity
HPY10_01880	COG1127	ABC transporter
HPY10_01885	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPY10_01890	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY10_01895	COG2854	intermembrane phospholipid transfer
HPY10_01905	COG5007	Belongs to the BolA IbaG family
HPY10_01910	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPY10_01920	COG0251	oxidation-reduction process
HPY10_01930	COG0540	Belongs to the ATCase OTCase family
HPY10_01940	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HPY10_01945	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPY10_01950	COG0564	pseudouridine synthase activity
HPY10_01955	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY10_01960	COG0525	valine-tRNA ligase activity
HPY10_01965	COG2927	DNA polymerase III (CHI subunit)
HPY10_01970	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY10_01975	COG0795	lipopolysaccharide-transporting ATPase activity
HPY10_01980	COG0795	lipopolysaccharide-transporting ATPase activity
HPY10_01995	COG3437	response regulator, receiver
HPY10_02035	COG0066	3-isopropylmalate dehydratase activity
HPY10_02040	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HPY10_02045	COG0473	3-isopropylmalate dehydrogenase activity
HPY10_02065	COG0583	DNA-binding transcription factor activity
HPY10_02070	COG1022	Amp-dependent synthetase and ligase
HPY10_02075	COG0028	Belongs to the TPP enzyme family
HPY10_02080	COG0440	acetolactate synthase activity
HPY10_02085	COG3385	transposase activity
HPY10_02090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY10_02095	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HPY10_02100	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPY10_02110	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HPY10_02115	COG3079	Belongs to the UPF0149 family
HPY10_02120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY10_02125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY10_02140	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HPY10_02150	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPY10_02155	COG1595	DNA-templated transcription, initiation
HPY10_02170	COG3086	response to oxidative stress
HPY10_02175	COG0481	GTPase activity
HPY10_02185	COG0571	ribonuclease III activity
HPY10_02190	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPY10_02195	COG1381	Involved in DNA repair and RecF pathway recombination
HPY10_02200	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HPY10_02235	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY10_02240	COG3956	TIGRFAM MazG family protein
HPY10_02245	COG0504	CTP synthase activity
HPY10_02250	COG0148	phosphopyruvate hydratase activity
HPY10_02260	COG3267	Type II secretory pathway component ExeA
HPY10_02260	COG3409	Peptidoglycan-binding domain 1 protein
HPY10_02270	COG4991	sh3 domain protein
HPY10_02275	COG0306	phosphate transporter
HPY10_02280	COG1392	Phosphate transport regulator
HPY10_02285	COG3025	triphosphatase activity
HPY10_02290	COG0840	transmembrane signaling receptor activity
HPY10_02295	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HPY10_02300	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPY10_02300	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HPY10_02305	COG1538	Outer membrane efflux protein
HPY10_02310	COG0494	nUDIX hydrolase
HPY10_02315	COG3151	Protein conserved in bacteria
HPY10_02325	COG3150	esterase
HPY10_02330	COG0187	DNA topoisomerase II activity
HPY10_02335	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPY10_02345	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HPY10_02350	COG0237	dephospho-CoA kinase activity
HPY10_02360	COG1459	type II secretion system
HPY10_02365	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY10_02385	COG0716	FMN binding
HPY10_02390	COG4974	Belongs to the 'phage' integrase family
HPY10_02395	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY10_02400	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPY10_02405	COG2186	Transcriptional regulator
HPY10_02410	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPY10_02415	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY10_02420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY10_02435	COG3116	cell division
HPY10_02440	COG0768	penicillin binding
HPY10_02445	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPY10_02450	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPY10_02460	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPY10_02465	COG0772	Belongs to the SEDS family
HPY10_02470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPY10_02475	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY10_02480	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPY10_02485	COG0849	cell division
HPY10_02490	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPY10_02495	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HPY10_02505	COG0653	protein targeting
HPY10_02510	COG0494	nUDIX hydrolase
HPY10_02515	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HPY10_02525	COG0505	Belongs to the CarA family
HPY10_02530	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPY10_02545	COG0730	response to heat
HPY10_02550	COG0583	DNA-binding transcription factor activity
HPY10_02555	COG2860	membrane
HPY10_02560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPY10_02570	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPY10_02580	COG0493	'glutamate synthase
HPY10_02585	COG0070	glutamate synthase
HPY10_02585	COG0069	glutamate synthase activity
HPY10_02585	COG0067	glutamate synthase
HPY10_02595	COG0069	glutamate synthase activity
HPY10_02595	COG0070	glutamate synthase
HPY10_02595	COG0067	glutamate synthase
HPY10_02600	COG1242	4 iron, 4 sulfur cluster binding
HPY10_02605	COG5001	Diguanylate cyclase
HPY10_02605	COG3706	GGDEF domain
HPY10_02605	COG2203	Gaf domain
HPY10_02605	COG4251	negative regulation of phosphorylation
HPY10_02610	COG5002	protein histidine kinase activity
HPY10_02610	COG2198	Histidine kinase
HPY10_02610	COG0784	Response regulator, receiver
HPY10_02615	COG0745	RESPONSE REGULATOR receiver
HPY10_02625	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY10_02645	COG0083	homoserine kinase activity
HPY10_02650	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPY10_02655	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HPY10_02660	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HPY10_02665	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPY10_02680	COG1115	amino acid carrier protein
HPY10_02685	COG3022	response to hydroperoxide
HPY10_02695	COG0084	hydrolase, TatD family'
HPY10_02700	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY10_02710	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HPY10_02715	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HPY10_02720	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HPY10_02725	COG0813	purine-nucleoside phosphorylase activity
HPY10_02735	COG0560	Phosphoserine phosphatase
HPY10_02745	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPY10_02750	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY10_02755	COG1022	Amp-dependent synthetase and ligase
HPY10_02770	COG3250	beta-galactosidase activity
HPY10_02780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY10_02795	COG0189	ligase activity
HPY10_02795	COG0569	domain protein
HPY10_02800	COG0456	acetyltransferase
HPY10_02810	COG2171	N-acyltransferase activity
HPY10_02815	COG3141	response to X-ray
HPY10_02830	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HPY10_02835	COG1074	ATP-dependent DNA helicase activity
HPY10_02840	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HPY10_02850	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY10_02850	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPY10_02860	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HPY10_02865	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPY10_02870	COG2166	iron-sulfur cluster assembly
HPY10_02875	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY10_02880	COG0693	protein deglycase activity
HPY10_02885	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPY10_02890	COG3248	Nucleoside-binding outer membrane protein
HPY10_02900	COG1595	DNA-templated transcription, initiation
HPY10_02910	COG2211	Major facilitator Superfamily
HPY10_02925	COG2813	Specifically methylates the guanine in position
HPY10_02930	COG0271	Belongs to the BolA IbaG family
HPY10_02935	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY10_02940	COG1805	sodium ion transport
HPY10_02945	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY10_02950	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY10_02955	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY10_02960	COG2871	sodium ion transport
HPY10_02965	COG1477	protein flavinylation
HPY10_02985	COG3706	GGDEF domain
HPY10_02990	COG0733	neurotransmitter:sodium symporter activity
HPY10_03000	COG0189	ligase activity
HPY10_03005	COG0189	ligase activity
HPY10_03005	COG4067	protein conserved in archaea
HPY10_03010	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY10_03015	COG2252	PERMEase
HPY10_03020	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HPY10_03035	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPY10_03040	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HPY10_03045	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPY10_03050	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY10_03050	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY10_03065	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HPY10_03070	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY10_03075	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HPY10_03080	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPY10_03090	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HPY10_03095	COG0024	Methionine aminopeptidase
HPY10_03100	COG0052	Belongs to the universal ribosomal protein uS2 family
HPY10_03105	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPY10_03110	COG0528	UMP kinase activity
HPY10_03115	COG0233	cytoplasmic translational termination
HPY10_03120	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPY10_03125	COG0575	Belongs to the CDS family
HPY10_03130	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HPY10_03135	COG0750	zinc metalloprotease
HPY10_03145	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HPY10_03150	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY10_03155	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY10_03160	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY10_03165	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY10_03170	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPY10_03175	COG0587	DNA-directed DNA polymerase activity
HPY10_03180	COG0825	malonyl-CoA metabolic process
HPY10_03185	COG0037	tRNA processing
HPY10_03195	COG3479	Phenolic acid decarboxylase
HPY10_03200	COG0347	Belongs to the P(II) protein family
HPY10_03205	COG3021	interspecies interaction between organisms
HPY10_03210	COG1388	LysM domain
HPY10_03210	COG0741	lytic transglycosylase activity
HPY10_03215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY10_03220	COG2226	methyltransferase
HPY10_03225	COG0328	RNA-DNA hybrid ribonuclease activity
HPY10_03240	COG1960	acyl-CoA dehydrogenase activity
HPY10_03245	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY10_03250	COG0121	glutamine amidotransferase
HPY10_03255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPY10_03260	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPY10_03265	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPY10_03270	COG3706	GGDEF domain
HPY10_03275	COG1187	pseudouridine synthase activity
HPY10_03280	COG2840	Smr protein MutS2
HPY10_03295	COG3735	TraB family
HPY10_03310	COG2608	mercury ion transmembrane transporter activity
HPY10_03310	COG2217	Heavy metal translocating P-type atpase
HPY10_03315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY10_03330	COG1629	transport
HPY10_03330	COG4774	siderophore transport
HPY10_03335	COG2375	cellular response to nickel ion
HPY10_03340	COG2226	methyltransferase
HPY10_03340	COG3433	isochorismatase activity
HPY10_03340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY10_03375	COG0835	chemotaxis
HPY10_03375	COG0784	Response regulator, receiver
HPY10_03380	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY10_03385	COG1815	bacterial-type flagellum-dependent cell motility
HPY10_03400	COG1749	Flagellar hook protein flgE
HPY10_03405	COG4787	bacterial-type flagellum-dependent cell motility
HPY10_03415	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HPY10_03420	COG1706	bacterial-type flagellum-dependent cell motility
HPY10_03425	COG1705	Flagellar rod assembly protein muramidase FlgJ
HPY10_03425	COG3951	Flagellar rod assembly protein muramidase FlgJ
HPY10_03440	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY10_03445	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY10_03530	COG0012	GTP binding
HPY10_03535	COG0193	aminoacyl-tRNA hydrolase activity
HPY10_03540	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPY10_03545	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPY10_03550	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HPY10_03555	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HPY10_03560	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPY10_03565	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY10_03575	COG2912	Transglutaminase-like superfamily
HPY10_03580	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HPY10_03585	COG0737	Belongs to the 5'-nucleotidase family
HPY10_03590	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPY10_03595	COG2233	PERMEase
HPY10_03615	COG1393	Belongs to the ArsC family
HPY10_03620	COG4783	chaperone-mediated protein folding
HPY10_03640	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPY10_03655	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HPY10_03665	COG1876	peptidase activity
HPY10_03675	COG1393	Belongs to the ArsC family
HPY10_03695	COG2837	iron assimilation
HPY10_03700	COG2706	6-phosphogluconolactonase activity
HPY10_03710	COG0800	Aldolase
HPY10_03720	COG4145	pantothenate transmembrane transporter activity
HPY10_03730	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HPY10_03740	COG0837	glucose binding
HPY10_03740	COG1737	Transcriptional regulator
HPY10_03745	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY10_03750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY10_03755	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY10_03760	COG1334	flagellar protein FlaG
HPY10_03765	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPY10_03775	COG1516	flagellar protein fliS
HPY10_03785	COG4191	Histidine kinase
HPY10_03795	COG1677	Flagellar hook-basal body complex protein FliE
HPY10_03805	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPY10_03835	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY10_03860	COG1987	bacterial-type flagellum assembly
HPY10_03865	COG1684	flagellar biosynthetic protein fliR
HPY10_03875	COG2840	Smr protein MutS2
HPY10_03880	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY10_03885	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPY10_03890	COG2860	membrane
HPY10_03895	COG3101	peptidyl-lysine hydroxylation
HPY10_03905	COG0431	NADPH-dependent FMN reductase
HPY10_03910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPY10_03910	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HPY10_03915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY10_03920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY10_03925	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY10_03930	COG0735	belongs to the Fur family
HPY10_03940	COG0583	DNA-binding transcription factor activity
HPY10_03950	COG1346	cytolysis
HPY10_03965	COG0596	Alpha beta hydrolase
HPY10_03970	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HPY10_03975	COG0033	Phosphoglucomutase
HPY10_03985	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPY10_03990	COG0372	Belongs to the citrate synthase family
HPY10_03995	COG2009	succinate dehydrogenase
HPY10_04000	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HPY10_04005	COG1053	succinate dehydrogenase
HPY10_04015	COG0567	Dehydrogenase, E1 component
HPY10_04020	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY10_04025	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY10_04035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPY10_04040	COG1121	(ABC) transporter
HPY10_04045	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HPY10_04050	COG4977	sequence-specific DNA binding
HPY10_04055	COG1918	ferrous iron import across plasma membrane
HPY10_04075	COG0018	arginyl-trna synthetase
HPY10_04085	COG1025	Belongs to the peptidase M16 family
HPY10_04090	COG2062	phosphohistidine phosphatase, SixA
HPY10_04120	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HPY10_04125	COG0643	Histidine kinase
HPY10_04125	COG0784	Response regulator, receiver
HPY10_04125	COG2198	Histidine kinase
HPY10_04130	COG2201	protein-glutamate methylesterase activity
HPY10_04135	COG1192	Involved in chromosome partitioning
HPY10_04145	COG0835	chemotaxis
HPY10_04155	COG4133	protoheme IX ABC transporter activity
HPY10_04160	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY10_04165	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY10_04175	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HPY10_04180	COG1138	Cytochrome C-type biogenesis protein
HPY10_04185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPY10_04190	COG4235	cytochrome complex assembly
HPY10_04190	COG3088	subunit of a heme lyase
HPY10_04200	COG2853	Lipoprotein
HPY10_04220	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HPY10_04225	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY10_04230	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPY10_04245	COG3083	sulfuric ester hydrolase activity
HPY10_04250	COG3082	Protein of unknown function (DUF1414)
HPY10_04255	COG3081	Nucleoid-associated protein
HPY10_04265	COG1757	Na H antiporter
HPY10_04270	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY10_04275	COG2095	MarC family integral membrane protein
HPY10_04280	COG1012	belongs to the aldehyde dehydrogenase family
HPY10_04280	COG1454	alcohol dehydrogenase
HPY10_04290	COG0659	secondary active sulfate transmembrane transporter activity
HPY10_04295	COG1530	ribonuclease E activity
HPY10_04300	COG0564	pseudouridine synthase activity
HPY10_04305	COG0424	maF-like protein
HPY10_04310	COG1399	metal-binding, possibly nucleic acid-binding protein
HPY10_04315	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPY10_04320	COG0416	fatty acid biosynthetic process
HPY10_04325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY10_04335	COG1028	Short-chain dehydrogenase reductase Sdr
HPY10_04340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPY10_04345	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY10_04350	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY10_04355	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPY10_04360	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPY10_04370	COG0084	hydrolase, TatD family'
HPY10_04375	COG1263	PTS System
HPY10_04375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY10_04385	COG0733	neurotransmitter:sodium symporter activity
HPY10_04400	COG4667	esterase of the alpha-beta hydrolase superfamily
HPY10_04410	COG1940	carbohydrate kinase activity
HPY10_04415	COG0784	Response regulator, receiver
HPY10_04415	COG0835	chemotaxis
HPY10_04430	COG2226	methyltransferase
HPY10_04440	COG0676	glucose-6-phosphate 1-epimerase activity
HPY10_04445	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY10_04450	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY10_04460	COG3139	Protein of unknown function (DUF1315)
HPY10_04465	COG0252	asparaginase activity
HPY10_04470	COG0616	signal peptide processing
HPY10_04475	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY10_04475	COG1902	pentaerythritol trinitrate reductase activity
HPY10_04480	COG0788	formyltetrahydrofolate deformylase activity
HPY10_04490	COG1199	ATP-dependent helicase activity
HPY10_04495	COG1214	PFAM Peptidase M22, glycoprotease
HPY10_04510	COG0596	Alpha beta hydrolase
HPY10_04515	COG0318	PFAM AMP-dependent synthetase and ligase
HPY10_04520	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HPY10_04535	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HPY10_04540	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HPY10_04545	COG0436	Aminotransferase
HPY10_04550	COG1169	isochorismate synthase
HPY10_04555	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HPY10_04560	COG0596	Alpha beta hydrolase
HPY10_04580	COG3135	benzoate transporter
HPY10_04605	COG3015	lipoprotein NlpE involved in copper resistance
HPY10_04610	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HPY10_04615	COG2894	cell division
HPY10_04620	COG0850	regulation of cytokinetic process
HPY10_04625	COG3100	YcgL domain-containing protein
HPY10_04630	COG2951	lytic endotransglycosylase activity
HPY10_04640	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY10_04645	COG3005	denitrification pathway
HPY10_04650	COG0243	molybdopterin cofactor binding
HPY10_04665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY10_04680	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPY10_04715	COG0653	protein targeting
HPY10_04825	COG4589	Belongs to the CDS family
HPY10_04835	COG5001	Diguanylate cyclase
HPY10_04835	COG3300	MHYT domain
HPY10_04845	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HPY10_04850	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPY10_04855	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY10_04860	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPY10_04870	COG4191	Histidine kinase
HPY10_04880	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPY10_04890	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPY10_04895	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPY10_04900	COG0776	regulation of translation
HPY10_04905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY10_04910	COG1555	photosystem II stabilization
HPY10_04915	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HPY10_04920	COG0539	negative regulation of cytoplasmic translation
HPY10_04925	COG0776	regulation of translation
HPY10_04930	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HPY10_04935	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HPY10_04955	COG0583	DNA-binding transcription factor activity
HPY10_04965	COG0686	Belongs to the AlaDH PNT family
HPY10_04975	COG1674	ftsk spoiiie
HPY10_04980	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPY10_04985	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY10_04990	COG2186	Transcriptional regulator
HPY10_05005	COG0537	adenosine 5'-monophosphoramidase activity
HPY10_05030	COG3150	esterase
HPY10_05035	COG1252	NADH dehydrogenase
HPY10_05060	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPY10_05070	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY10_05075	COG1136	(ABC) transporter
HPY10_05080	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY10_05090	COG0658	competence protein
HPY10_05090	COG2333	competence protein COMEC
HPY10_05095	COG1132	(ABC) transporter
HPY10_05100	COG1663	tetraacyldisaccharide 4'-kinase activity
HPY10_05105	COG2835	tetraacyldisaccharide 4'-kinase activity
HPY10_05110	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPY10_05115	COG2719	SpoVR family
HPY10_05120	COG2718	Belongs to the UPF0229 family
HPY10_05125	COG2766	serine protein kinase
HPY10_05130	COG3013	Belongs to the UPF0304 family
HPY10_05140	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPY10_05145	COG0840	transmembrane signaling receptor activity
HPY10_05155	COG1882	Formate acetyltransferase
HPY10_05180	COG4160	amino acid transport
HPY10_05185	COG0708	Exodeoxyribonuclease III
HPY10_05195	COG3923	Primosomal replication protein n
HPY10_05200	COG0730	response to heat
HPY10_05205	COG1199	ATP-dependent helicase activity
HPY10_05215	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY10_05220	COG3012	SEC-C Motif Domain Protein
HPY10_05225	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY10_05230	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY10_05235	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPY10_05240	COG0215	cysteine-tRNA ligase activity
HPY10_05245	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HPY10_05250	COG0632	four-way junction helicase activity
HPY10_05260	COG1271	oxidase subunit
HPY10_05265	COG1294	oxidase, subunit
HPY10_05270	COG4890	Cyd operon protein YbgT
HPY10_05275	COG3790	cyd operon protein YbgE
HPY10_05280	COG0824	Thioesterase
HPY10_05285	COG0811	peptide transport
HPY10_05300	COG0823	Involved in the tonB-independent uptake of proteins
HPY10_05305	COG2885	chlorophyll binding
HPY10_05315	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPY10_05335	COG1482	cell wall glycoprotein biosynthetic process
HPY10_05340	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY10_05340	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY10_05340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY10_05345	COG2207	Transcriptional regulator
HPY10_05355	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY10_05360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY10_05365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY10_05375	COG1012	belongs to the aldehyde dehydrogenase family
HPY10_05380	COG3284	Transcriptional regulator
HPY10_05385	COG4628	conserved protein (DUF2132)
HPY10_05395	COG0415	Belongs to the DNA photolyase family
HPY10_05430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY10_05440	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY10_05440	COG3008	intermembrane lipid transfer
HPY10_05445	COG2995	paraquat-inducible protein a
HPY10_05450	COG0668	transmembrane transport
HPY10_05470	COG1309	transcriptional regulator
HPY10_05475	COG1012	belongs to the aldehyde dehydrogenase family
HPY10_05495	COG1960	acyl-CoA dehydrogenase activity
HPY10_05500	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY10_05505	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPY10_05515	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HPY10_05530	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY10_05535	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY10_05540	COG0297	glycogen (starch) synthase activity
HPY10_05560	COG3070	regulator of competence-specific genes
HPY10_05565	COG1609	Transcriptional regulator
HPY10_05575	COG0745	RESPONSE REGULATOR receiver
HPY10_05580	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY10_05585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY10_05590	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HPY10_05595	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HPY10_05610	COG1280	lysine exporter protein (LysE YggA)
HPY10_05615	COG1032	radical SAM domain protein
HPY10_05620	COG5001	Diguanylate cyclase
HPY10_05625	COG0612	Peptidase, M16
HPY10_05640	COG0583	DNA-binding transcription factor activity
HPY10_05645	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HPY10_05655	COG2350	Protein conserved in bacteria
HPY10_05660	COG1607	acyl-coa hydrolase
HPY10_05675	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY10_05680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY10_05690	COG2116	formate transmembrane transporter activity
HPY10_05695	COG4459	periplasmic nitrate reductase
HPY10_05700	COG3005	denitrification pathway
HPY10_05705	COG0243	molybdopterin cofactor binding
HPY10_05725	COG1227	inorganic diphosphatase activity
HPY10_05745	COG4172	Belongs to the ABC transporter superfamily
HPY10_05760	COG4168	peptide transport system, permease
HPY10_05770	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HPY10_05775	COG1842	Phage shock protein A
HPY10_05790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY10_05805	COG2818	Glycosylase
HPY10_05810	COG0626	cystathionine gamma-synthase activity
HPY10_05820	COG0733	neurotransmitter:sodium symporter activity
HPY10_05845	COG0564	pseudouridine synthase activity
HPY10_05850	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPY10_05855	COG4136	ATPase activity
HPY10_05860	COG4135	transport system, permease component
HPY10_05865	COG4134	Bacterial extracellular solute-binding protein
HPY10_05875	COG3313	Fe-S protein
HPY10_05885	COG0814	amino acid
HPY10_05895	COG2239	Acts as a magnesium transporter
HPY10_05900	COG2205	protein histidine kinase activity
HPY10_05900	COG0784	Response regulator, receiver
HPY10_05915	COG4934	collagen metabolic process
HPY10_05950	COG0840	transmembrane signaling receptor activity
HPY10_05960	COG5001	Diguanylate cyclase
HPY10_05960	COG3706	GGDEF domain
HPY10_05960	COG2203	Gaf domain
HPY10_05960	COG4251	negative regulation of phosphorylation
HPY10_05965	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HPY10_05985	COG1061	Type III restriction enzyme res subunit
HPY10_05990	COG1187	pseudouridine synthase activity
HPY10_05995	COG2814	Major facilitator Superfamily
HPY10_06005	COG0702	epimerase
HPY10_06010	COG0534	Mate efflux family protein
HPY10_06015	COG4181	ATPase activity
HPY10_06030	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY10_06040	COG1748	Saccharopine dehydrogenase
HPY10_06055	COG1538	Outer membrane efflux protein
HPY10_06120	COG0583	DNA-binding transcription factor activity
HPY10_06130	COG1451	nucleotide metabolic process
HPY10_06145	COG3063	Type IV pilus biogenesis stability protein PilW
HPY10_06150	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HPY10_06170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY10_06185	COG3290	protein histidine kinase activity
HPY10_06190	COG4565	transcriptional regulatory protein
HPY10_06200	COG0835	chemotaxis
HPY10_06200	COG0784	Response regulator, receiver
HPY10_06250	COG1085	galactose-1-phosphate uridylyltransferase
HPY10_06255	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPY10_06260	COG2017	converts alpha-aldose to the beta-anomer
HPY10_06275	COG3527	Alpha-acetolactate decarboxylase
HPY10_06285	COG3064	Membrane
HPY10_06295	COG0753	catalase activity
HPY10_06315	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY10_06365	COG1271	oxidase subunit
HPY10_06370	COG1294	oxidase, subunit
HPY10_06375	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY10_06375	COG1136	(ABC) transporter
HPY10_06380	COG0577	efflux transmembrane transporter activity
HPY10_06380	COG1136	(ABC) transporter
HPY10_06385	COG1136	(ABC) transporter
HPY10_06385	COG0577	efflux transmembrane transporter activity
HPY10_06415	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HPY10_06460	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY10_06475	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY10_06485	COG2723	6-phospho-beta-galactosidase activity
HPY10_06490	COG1609	Transcriptional regulator
HPY10_06495	COG0251	oxidation-reduction process
HPY10_06500	COG2731	YhcH YjgK YiaL family protein
HPY10_06505	COG0584	glycerophosphoryl diester phosphodiesterase
HPY10_06510	COG1349	DNA-binding transcription factor activity
HPY10_06515	COG3842	ATPase activity
HPY10_06520	COG0395	ABC-type sugar transport system, permease component
HPY10_06525	COG1175	transmembrane transport
HPY10_06540	COG0811	peptide transport
HPY10_06545	COG0811	peptide transport
HPY10_06550	COG0848	biopolymer transport protein
HPY10_06555	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY10_06565	COG1793	dna ligase
HPY10_06575	COG0534	Mate efflux family protein
HPY10_06585	COG3001	Fructosamine kinase
HPY10_06595	COG0791	NLP P60 protein
HPY10_06600	COG0840	transmembrane signaling receptor activity
HPY10_06615	COG1940	carbohydrate kinase activity
HPY10_06625	COG0303	'Molybdopterin
HPY10_06630	COG0746	molybdenum cofactor guanylyltransferase activity
HPY10_06635	COG3842	ATPase activity
HPY10_06640	COG4662	Binding-protein-dependent transport system inner membrane component
HPY10_06650	COG2204	response regulator
HPY10_06655	COG3852	Histidine kinase
HPY10_06660	COG0488	(ABC) transporter
HPY10_06665	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPY10_06695	COG3383	formate dehydrogenase (NAD+) activity
HPY10_06695	COG0243	molybdopterin cofactor binding
HPY10_06700	COG0437	4 iron, 4 sulfur cluster binding
HPY10_06715	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPY10_06720	COG1666	GTP binding
HPY10_06725	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY10_06740	COG2996	Protein conserved in bacteria
HPY10_06750	COG3008	intermembrane lipid transfer
HPY10_06755	COG2995	paraquat-inducible protein a
HPY10_06760	COG1132	(ABC) transporter
HPY10_06765	COG1956	GAF domain-containing protein
HPY10_06770	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HPY10_06785	COG0308	aminopeptidase N
HPY10_06800	COG0167	dihydroorotate dehydrogenase activity
HPY10_06810	COG0116	Belongs to the methyltransferase superfamily
HPY10_06810	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY10_06835	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY10_06840	COG1067	ATP-dependent peptidase activity
HPY10_06845	COG3120	sequence-specific DNA binding
HPY10_07010	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HPY10_07010	COG3064	Membrane
HPY10_07010	COG1073	alpha beta
HPY10_07015	COG2994	toxin metabolic process
HPY10_07040	COG2205	protein histidine kinase activity
HPY10_07040	COG0784	Response regulator, receiver
HPY10_07055	COG3278	Belongs to the heme-copper respiratory oxidase family
HPY10_07070	COG2010	Cytochrome c
HPY10_07080	COG2217	Heavy metal translocating P-type atpase
HPY10_07095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPY10_07100	COG0589	response to stress
HPY10_07105	COG0037	tRNA processing
HPY10_07125	COG3842	ATPase activity
HPY10_07135	COG1177	transmembrane transport
HPY10_07145	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY10_07160	COG1115	amino acid carrier protein
HPY10_07165	COG1280	lysine exporter protein (LysE YggA)
HPY10_07195	COG3501	Rhs element vgr protein
HPY10_07205	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HPY10_07210	COG1960	acyl-CoA dehydrogenase activity
HPY10_07220	COG1012	belongs to the aldehyde dehydrogenase family
HPY10_07225	COG3384	dioxygenase
HPY10_07260	COG3971	2-oxopent-4-enoate hydratase activity
HPY10_07280	COG1846	Transcriptional regulator
HPY10_07340	COG0513	Belongs to the DEAD box helicase family
HPY10_07345	COG2076	Multidrug Resistance protein
HPY10_07350	COG0477	Major facilitator Superfamily
HPY10_07355	COG0583	DNA-binding transcription factor activity
HPY10_07365	COG0402	S-adenosylhomocysteine deaminase activity
HPY10_07370	COG0095	Lipoate-protein ligase
HPY10_07375	COG0443	Heat shock 70 kDa protein
HPY10_07385	COG1643	Atp-dependent helicase
HPY10_07415	COG0443	Heat shock 70 kDa protein
HPY10_07420	COG0443	Heat shock 70 kDa protein
HPY10_07425	COG3706	GGDEF domain
HPY10_07455	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HPY10_07460	COG0602	queuosine metabolic process
HPY10_07465	COG0561	phosphatase activity
HPY10_07475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY10_07480	COG4597	amino acid ABC transporter
HPY10_07485	COG0765	amino acid transport
HPY10_07490	COG1126	abc transporter atp-binding protein
HPY10_07495	COG0670	Belongs to the BI1 family
HPY10_07500	COG2920	part of a sulfur-relay system
HPY10_07505	COG1254	Belongs to the acylphosphatase family
HPY10_07510	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY10_07515	COG3706	GGDEF domain
HPY10_07525	COG2205	protein histidine kinase activity
HPY10_07525	COG4999	Histidine kinase
HPY10_07525	COG3437	response regulator, receiver
HPY10_07525	COG3850	Histidine kinase
HPY10_07530	COG3437	response regulator, receiver
HPY10_07535	COG0625	glutathione transferase activity
HPY10_07545	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HPY10_07555	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY10_07585	COG0372	Belongs to the citrate synthase family
HPY10_07590	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HPY10_07615	COG0583	DNA-binding transcription factor activity
HPY10_07620	COG4771	TonB-dependent receptor
HPY10_07645	COG1566	PFAM secretion protein HlyD family protein
HPY10_07665	COG1129	ABC transporter
HPY10_07690	COG0745	RESPONSE REGULATOR receiver
HPY10_07695	COG5002	protein histidine kinase activity
HPY10_07700	COG3713	MltA-interacting MipA family protein
HPY10_07705	COG2990	Protein conserved in bacteria
HPY10_07715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY10_07715	COG4191	Histidine kinase
HPY10_07720	COG0471	metal ion transport
HPY10_07730	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY10_07745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY10_07755	COG3768	UPF0283 membrane protein
HPY10_07760	COG3106	COG3106 Predicted ATPase
HPY10_07775	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY10_07780	COG0494	nUDIX hydrolase
HPY10_07785	COG0814	amino acid
HPY10_07790	COG1760	l-serine dehydratase
HPY10_07795	COG0720	synthase
HPY10_07800	COG0840	transmembrane signaling receptor activity
HPY10_07805	COG0017	Asparaginyl-tRNA synthetase
HPY10_07810	COG0351	phosphomethylpyrimidine kinase
HPY10_07815	COG2770	Histidine kinase
HPY10_07815	COG3437	response regulator, receiver
HPY10_07820	COG1448	Aminotransferase
HPY10_07835	COG0840	transmembrane signaling receptor activity
HPY10_07840	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HPY10_07845	COG2943	transferase activity, transferring hexosyl groups
HPY10_07850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY10_07855	COG1846	Transcriptional regulator
HPY10_07880	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY10_07895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY10_07900	COG3108	Peptidase M15
HPY10_07930	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPY10_07940	COG2814	Major facilitator Superfamily
HPY10_07960	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY10_07965	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY10_07970	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY10_08015	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HPY10_08020	COG4139	cobalamin transport
HPY10_08025	COG2988	succinylglutamate desuccinylase activity
HPY10_08040	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HPY10_08045	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HPY10_08050	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY10_08060	COG2925	Exonuclease
HPY10_08065	COG1380	Effector of murein hydrolase LrgA
HPY10_08070	COG1346	cytolysis
HPY10_08090	COG0500	methyltransferase
HPY10_08100	COG0776	regulation of translation
HPY10_08105	COG0072	phenylalanine-tRNA ligase activity
HPY10_08105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY10_08110	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPY10_08150	COG0322	excinuclease ABC activity
HPY10_08155	COG2197	response regulator
HPY10_08160	COG0417	DNA replication proofreading
HPY10_08165	COG5001	Diguanylate cyclase
HPY10_08175	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY10_08180	COG3099	Belongs to the UPF0263 family
HPY10_08195	COG1228	amidohydrolase
HPY10_08200	COG0010	Belongs to the arginase family
HPY10_08205	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPY10_08210	COG2986	histidine ammonia-lyase
HPY10_08230	COG0247	lactate metabolic process
HPY10_08230	COG0277	FAD linked oxidase domain protein
HPY10_08245	COG2885	chlorophyll binding
HPY10_08265	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPY10_08275	COG0281	malic enzyme
HPY10_08285	COG2949	membrane
HPY10_08290	COG3706	GGDEF domain
HPY10_08295	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY10_08305	COG0492	ferredoxin-NADP+ reductase activity
HPY10_08310	COG4988	ABC transporter
HPY10_08315	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPY10_08320	COG1187	pseudouridine synthase activity
HPY10_08325	COG0009	L-threonylcarbamoyladenylate synthase
HPY10_08330	COG0613	PHP domain protein
HPY10_08340	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY10_08345	COG0512	Glutamine amidotransferase of anthranilate synthase
HPY10_08350	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPY10_08355	COG0134	indole-3-glycerol-phosphate synthase activity
HPY10_08355	COG0135	phosphoribosylanthranilate isomerase activity
HPY10_08360	COG0133	tryptophan synthase activity
HPY10_08365	COG0159	tryptophan synthase activity
HPY10_08375	COG1435	thymidine kinase activity
HPY10_08380	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPY10_08390	COG4106	trans-aconitate 2-methyltransferase activity
HPY10_08395	COG0500	methyltransferase
HPY10_08400	COG0189	ligase activity
HPY10_08400	COG4067	protein conserved in archaea
HPY10_08415	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HPY10_08425	COG3852	Histidine kinase
HPY10_08440	COG3070	regulator of competence-specific genes
HPY10_08450	COG2431	L-lysine efflux transmembrane transporter activity
HPY10_08460	COG0076	glutamate decarboxylase activity
HPY10_08465	COG1737	Transcriptional regulator
HPY10_08470	COG1454	alcohol dehydrogenase
HPY10_08470	COG1012	belongs to the aldehyde dehydrogenase family
HPY10_08475	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY10_08480	COG3273	potassium ion transport
HPY10_08480	COG2985	domain, Protein
HPY10_08485	COG0542	response to heat
HPY10_08490	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPY10_08495	COG1278	Cold shock
HPY10_08505	COG1187	pseudouridine synthase activity
HPY10_08510	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HPY10_08510	COG0140	phosphoribosyl-ATP diphosphatase activity
HPY10_08515	COG0107	imidazoleglycerol-phosphate synthase activity
HPY10_08520	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY10_08525	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPY10_08530	COG0131	Imidazoleglycerol-phosphate dehydratase
HPY10_08530	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY10_08535	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPY10_08540	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPY10_08545	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HPY10_08550	COG1757	Na H antiporter
HPY10_08555	COG2916	Histone family protein nucleoid-structuring protein H-NS
HPY10_08560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY10_08565	COG0482	sulfurtransferase activity
HPY10_08570	COG2915	High frequency lysogenization protein hflD homolog
HPY10_08575	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPY10_08585	COG2268	Band 7 protein
HPY10_08595	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPY10_08610	COG0300	oxidoreductase activity
HPY10_08620	COG0501	Belongs to the peptidase M48B family
HPY10_08630	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPY10_08635	COG2226	methyltransferase
HPY10_08640	COG0156	8-amino-7-oxononanoate synthase activity
HPY10_08645	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY10_08650	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPY10_08655	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPY10_08660	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPY10_08665	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPY10_08670	COG0653	protein targeting
HPY10_08675	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY10_08680	COG3706	GGDEF domain
HPY10_08690	COG4120	Belongs to the binding-protein-dependent transport system permease family
HPY10_08700	COG4628	conserved protein (DUF2132)
HPY10_08705	COG3092	negative regulation of chromosome organization
HPY10_08710	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY10_08715	COG0857	belongs to the CobB CobQ family
HPY10_08715	COG0280	phosphate acetyltransferase
HPY10_08720	COG0435	Glutathione S-transferase
HPY10_08725	COG4608	Belongs to the ABC transporter superfamily
HPY10_08730	COG0444	Belongs to the ABC transporter superfamily
HPY10_08735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY10_08740	COG0601	transmembrane transport
HPY10_08760	COG2204	response regulator
HPY10_08765	COG3300	MHYT domain
HPY10_08765	COG5001	Diguanylate cyclase
HPY10_08770	COG4191	Histidine kinase
HPY10_08775	COG5002	protein histidine kinase activity
HPY10_08785	COG2201	protein-glutamate methylesterase activity
HPY10_08800	COG0009	L-threonylcarbamoyladenylate synthase
HPY10_08815	COG1881	PFAM PEBP family protein
HPY10_08840	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY10_08845	COG0640	Transcriptional regulator
HPY10_08895	COG1396	sequence-specific DNA binding
HPY10_08920	COG3706	GGDEF domain
HPY10_08940	COG1946	Acyl-CoA thioesterase
HPY10_08945	COG1522	sequence-specific DNA binding
HPY10_08955	COG0616	signal peptide processing
HPY10_08960	COG1028	Short-chain dehydrogenase reductase Sdr
HPY10_08965	COG2983	Belongs to the UPF0260 family
HPY10_08975	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HPY10_08980	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HPY10_08990	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPY10_08995	COG2832	Protein of unknown function (DUF454)
HPY10_09000	COG0745	RESPONSE REGULATOR receiver
HPY10_09005	COG0583	DNA-binding transcription factor activity
HPY10_09010	COG0778	Nitroreductase
HPY10_09015	COG1024	Enoyl-CoA hydratase
HPY10_09015	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY10_09020	COG0183	Belongs to the thiolase family
HPY10_09035	COG2067	long-chain fatty acid transport protein
HPY10_09045	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY10_09050	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HPY10_09055	COG2982	Protein involved in outer membrane biogenesis
HPY10_09060	COG0572	uridine kinase
HPY10_09065	COG0489	protein tyrosine kinase activity
HPY10_09070	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY10_09070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY10_09080	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY10_09090	COG0617	tRNA 3'-terminal CCA addition
HPY10_09090	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HPY10_09090	COG0517	IMP dehydrogenase activity
HPY10_09095	COG2199	diguanylate cyclase activity
HPY10_09100	COG0314	molybdopterin synthase activity
HPY10_09105	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HPY10_09110	COG0315	cyclic pyranopterin monophosphate synthase activity
HPY10_09115	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPY10_09120	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPY10_09125	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HPY10_09130	COG2198	Histidine kinase
HPY10_09135	COG2204	response regulator
HPY10_09140	COG0556	nucleotide-excision repair
HPY10_09150	COG4657	Part of a membrane complex involved in electron transport
HPY10_09155	COG2878	Part of a membrane complex involved in electron transport
HPY10_09160	COG4656	Part of a membrane complex involved in electron transport
HPY10_09175	COG4660	Part of a membrane complex involved in electron transport
HPY10_09180	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPY10_09185	COG0346	lactoylglutathione lyase activity
HPY10_09200	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPY10_09205	COG2056	Na+-H+ antiporter family
HPY10_09210	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPY10_09215	COG1286	toxin biosynthetic process
HPY10_09220	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HPY10_09225	COG0285	dihydrofolate synthase activity
HPY10_09230	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPY10_09235	COG0101	tRNA pseudouridine synthase activity
HPY10_09250	COG2190	(PTS) system
HPY10_09250	COG1263	PTS System
HPY10_09250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY10_09255	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPY10_09260	COG1846	Transcriptional regulator
HPY10_09260	COG1940	carbohydrate kinase activity
HPY10_09265	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY10_09265	COG4651	solute:proton antiporter activity
HPY10_09270	COG0367	asparagine synthase
HPY10_09285	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPY10_09290	COG0563	adenylate kinase activity
HPY10_09295	COG0326	Molecular chaperone. Has ATPase activity
HPY10_09300	COG3710	Transcriptional regulator
HPY10_09315	COG0622	Phosphoesterase
HPY10_09320	COG1090	epimerase
HPY10_09325	COG0300	oxidoreductase activity
HPY10_09330	COG3118	belongs to the thioredoxin family
HPY10_09335	COG0330	HflC and HflK could
HPY10_09340	COG1585	Membrane protein implicated in regulation of membrane protease activity
HPY10_09345	COG0789	Transcriptional regulator
HPY10_09360	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPY10_09365	COG3115	cell septum assembly
HPY10_09370	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HPY10_09375	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPY10_09380	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY10_09390	COG2190	(PTS) system
HPY10_09395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY10_09400	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY10_09405	COG1702	phosphate starvation-inducible protein PhoH
HPY10_09415	COG4535	Mg2 and Co2 transporter CorC
HPY10_09420	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPY10_09425	COG2888	peptidyl-tyrosine sulfation
HPY10_09430	COG0495	leucyl-tRNA aminoacylation
HPY10_09435	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HPY10_09440	COG1466	dna polymerase III delta subunit
HPY10_09445	COG0799	negative regulation of ribosome biogenesis
HPY10_09450	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HPY10_09455	COG0768	penicillin binding
HPY10_09460	COG0772	Belongs to the SEDS family
HPY10_09465	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY10_09470	COG1686	Belongs to the peptidase S11 family
HPY10_09475	COG2921	Belongs to the UPF0250 family
HPY10_09480	COG0321	lipoyl(octanoyl) transferase activity
HPY10_09485	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPY10_09495	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY10_09520	COG1596	polysaccharide export
HPY10_09530	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY10_09560	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HPY10_09570	COG0438	transferase activity, transferring glycosyl groups
HPY10_09580	COG1045	serine acetyltransferase
HPY10_09600	COG0110	maltose O-acetyltransferase activity
HPY10_09605	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPY10_09610	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPY10_09615	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY10_09620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY10_09650	COG0366	Alpha amylase catalytic
HPY10_09655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY10_09655	COG1263	PTS System
HPY10_09660	COG1609	Transcriptional regulator
HPY10_09665	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY10_09670	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPY10_09675	COG2011	ABC-type metal ion transport system permease component
HPY10_09680	COG1464	Belongs to the NlpA lipoprotein family
HPY10_09685	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HPY10_09695	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY10_09695	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY10_09705	COG3706	GGDEF domain
HPY10_09710	COG1611	Belongs to the LOG family
HPY10_09715	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY10_09720	COG2363	Small membrane protein
HPY10_09725	COG0583	DNA-binding transcription factor activity
HPY10_09730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY10_09730	COG0301	tRNA thio-modification
HPY10_09740	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPY10_09745	COG1722	exodeoxyribonuclease VII activity
HPY10_09750	COG0142	geranyltranstransferase activity
HPY10_09755	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPY10_09760	COG0564	pseudouridine synthase activity
HPY10_09765	COG3098	single-species biofilm formation
HPY10_09780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY10_09790	COG1671	Belongs to the UPF0178 family
HPY10_09795	COG3385	transposase activity
HPY10_09800	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY10_09805	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY10_09810	COG0254	rRNA binding
HPY10_09815	COG1720	tRNA m6t6A37 methyltransferase activity
HPY10_09820	COG0442	prolyl-tRNA aminoacylation
HPY10_09840	COG0047	phosphoribosylformylglycinamidine synthase activity
HPY10_09840	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPY10_09850	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HPY10_09860	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY10_09890	COG0484	heat shock protein binding
HPY10_09895	COG0443	Heat shock 70 kDa protein
HPY10_09900	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPY10_09905	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPY10_09910	COG0497	DNA recombination
HPY10_09915	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY10_09920	COG2914	Belongs to the UPF0125 (RnfH) family
HPY10_09925	COG2867	negative regulation of translational initiation
HPY10_09930	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPY10_09940	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HPY10_09945	COG0732	type I restriction modification DNA specificity domain
HPY10_09950	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HPY10_09965	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HPY10_09970	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HPY10_09975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY10_10005	COG1115	amino acid carrier protein
HPY10_10010	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HPY10_10015	COG0583	DNA-binding transcription factor activity
HPY10_10025	COG1120	ATPase activity
HPY10_10030	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY10_10035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY10_10040	COG4592	Periplasmic binding protein
HPY10_10050	COG1028	Short-chain dehydrogenase reductase Sdr
HPY10_10055	COG1169	isochorismate synthase
HPY10_10060	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY10_10065	COG1535	isochorismatase
HPY10_10065	COG3433	isochorismatase activity
HPY10_10070	COG1584	GPR1 FUN34 yaaH family protein
HPY10_10080	COG3023	N-Acetylmuramoyl-L-alanine amidase
HPY10_10090	COG0519	Catalyzes the synthesis of GMP from XMP
HPY10_10090	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPY10_10095	COG0517	IMP dehydrogenase activity
HPY10_10095	COG0516	GMP reductase activity
HPY10_10100	COG1570	exodeoxyribonuclease VII activity
HPY10_10115	COG1160	GTP binding
HPY10_10120	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY10_10125	COG2976	Protein conserved in bacteria
HPY10_10130	COG0124	histidyl-tRNA synthetase
HPY10_10135	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HPY10_10150	COG0105	UTP biosynthetic process
HPY10_10155	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY10_10160	COG2975	iron-sulfur cluster assembly
HPY10_10165	COG0633	Ferredoxin
HPY10_10185	COG0822	iron-sulfur transferase activity
HPY10_10190	COG1104	cysteine desulfurase activity
HPY10_10195	COG1959	2 iron, 2 sulfur cluster binding
HPY10_10205	COG0483	inositol monophosphate 1-phosphatase activity
HPY10_10210	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY10_10215	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY10_10220	COG1862	Preprotein translocase
HPY10_10230	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HPY10_10235	COG0517	IMP dehydrogenase activity
HPY10_10245	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPY10_10250	COG0583	DNA-binding transcription factor activity
HPY10_10255	COG0450	alkyl hydroperoxide reductase
HPY10_10260	COG3142	Participates in the control of copper homeostasis
HPY10_10275	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY10_10280	COG0581	inorganic phosphate transmembrane transporter activity
HPY10_10290	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPY10_10295	COG0248	Ppx GppA phosphatase
HPY10_10305	COG5002	protein histidine kinase activity
HPY10_10310	COG0745	RESPONSE REGULATOR receiver
HPY10_10325	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY10_10370	COG0542	response to heat
HPY10_10380	COG0564	pseudouridine synthase activity
HPY10_10385	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY10_10390	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY10_10395	COG1605	Chorismate mutase
HPY10_10395	COG0077	Prephenate dehydratase
HPY10_10400	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY10_10405	COG5001	Diguanylate cyclase
HPY10_10415	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HPY10_10425	COG0488	(ABC) transporter
HPY10_10435	COG0287	Prephenate dehydrogenase
HPY10_10435	COG1605	Chorismate mutase
HPY10_10440	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY10_10445	COG3275	phosphorelay sensor kinase activity
HPY10_10450	COG3279	Response regulator of the LytR AlgR family
HPY10_10460	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HPY10_10465	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY10_10480	COG1966	Carbon starvation protein
HPY10_10485	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPY10_10490	COG1047	Peptidyl-prolyl cis-trans
HPY10_10495	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPY10_10505	COG0196	riboflavin kinase activity
HPY10_10510	COG0728	peptidoglycan biosynthetic process
HPY10_10515	COG0268	Binds directly to 16S ribosomal RNA
HPY10_10520	COG0640	Transcriptional regulator
HPY10_10525	COG0583	DNA-binding transcription factor activity
HPY10_10530	COG1283	sodium-dependent phosphate transmembrane transporter activity
HPY10_10540	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HPY10_10545	COG0730	response to heat
HPY10_10550	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HPY10_10555	COG0494	nUDIX hydrolase
HPY10_10565	COG0667	Aldo Keto reductase
HPY10_10575	COG2204	response regulator
HPY10_10580	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPY10_10600	COG0513	Belongs to the DEAD box helicase family
HPY10_10625	COG3153	acetyltransferase
HPY10_10630	COG3154	lipid carrier protein
HPY10_10640	COG0826	peptidase U32
HPY10_10645	COG0826	peptidase U32
HPY10_10660	COG3385	transposase activity
HPY10_10675	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HPY10_10685	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPY10_10690	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPY10_10695	COG0195	Participates in both transcription termination and antitermination
HPY10_10700	COG0779	Required for maturation of 30S ribosomal subunits
HPY10_10715	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY10_10725	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPY10_10730	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPY10_10735	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HPY10_10740	COG1534	Rna-binding protein
HPY10_10745	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY10_10750	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY10_10755	COG2027	D-alanyl-D-alanine carboxypeptidase
HPY10_10760	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY10_10765	COG0739	heme binding
HPY10_10780	COG0316	Belongs to the HesB IscA family
HPY10_10785	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPY10_10790	COG0628	permease
HPY10_10795	COG2813	Specifically methylates the guanine in position
HPY10_10805	COG0747	negative chemotaxis
HPY10_10815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY10_10820	COG0444	Belongs to the ABC transporter superfamily
HPY10_10825	COG4608	Belongs to the ABC transporter superfamily
HPY10_10835	COG2971	BadF BadG BcrA BcrD
HPY10_10855	COG3842	ATPase activity
HPY10_10865	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY10_10870	COG0004	ammonium transporteR
HPY10_10875	COG0347	Belongs to the P(II) protein family
HPY10_10880	COG3112	Uncharacterised protein family (UPF0231)
HPY10_10885	COG1049	propionate catabolic process, 2-methylcitrate cycle
HPY10_10890	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPY10_10895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPY10_10900	COG1643	Atp-dependent helicase
HPY10_10910	COG1489	DNA binding
HPY10_10920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY10_10930	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY10_10935	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HPY10_10940	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HPY10_10945	COG0842	Transport permease protein
HPY10_10950	COG1131	(ABC) transporter
HPY10_10955	COG0659	secondary active sulfate transmembrane transporter activity
HPY10_10960	COG0288	reversible hydration of carbon dioxide
HPY10_10975	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPY10_10980	COG3107	peptidoglycan biosynthetic process
HPY10_10985	COG0792	nuclease activity
HPY10_10990	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY10_10995	COG2823	Periplasmic or secreted lipoprotein
HPY10_11000	COG2969	positive regulation of protein catabolic process
HPY10_11005	COG0625	glutathione transferase activity
HPY10_11010	COG2857	Cytochrome c1
HPY10_11015	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPY10_11020	COG0723	plastoquinol--plastocyanin reductase activity
HPY10_11025	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HPY10_11030	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPY10_11035	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HPY10_11045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY10_11050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY10_11055	COG0335	large ribosomal subunit rRNA binding
HPY10_11060	COG0336	Belongs to the RNA methyltransferase TrmD family
HPY10_11065	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HPY10_11070	COG0228	four-way junction DNA binding
HPY10_11075	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPY10_11080	COG4137	Cytochrome C assembly protein
HPY10_11085	COG4536	flavin adenine dinucleotide binding
HPY10_11090	COG1854	S-ribosylhomocysteine lyase activity
HPY10_11095	COG2918	glutathione biosynthetic process
HPY10_11100	COG0612	Peptidase, M16
HPY10_11105	COG1238	metal cluster binding
HPY10_11115	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY10_11120	COG5016	pyruvate
HPY10_11120	COG0511	ligase activity, forming carbon-carbon bonds
HPY10_11125	COG3630	sodium ion export across plasma membrane
HPY10_11170	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HPY10_11175	COG0527	aspartate kinase activity
HPY10_11180	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPY10_11185	COG2137	regulation of response to DNA damage stimulus
HPY10_11190	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPY10_11200	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HPY10_11205	COG4208	sulfate ABC transporter
HPY10_11225	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HPY10_11230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY10_11240	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPY10_11245	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HPY10_11250	COG0585	pseudouridine synthase activity
HPY10_11255	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPY10_11260	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPY10_11265	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HPY10_11270	COG1968	undecaprenyl-diphosphatase activity
HPY10_11275	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY10_11280	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPY10_11285	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPY10_11295	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPY10_11300	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPY10_11305	COG1610	YqeY-like protein
HPY10_11330	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY10_11335	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPY10_11340	COG1349	DNA-binding transcription factor activity
HPY10_11360	COG1279	arginine transmembrane transporter activity
HPY10_11365	COG0668	transmembrane transport
HPY10_11370	COG0191	fructose-bisphosphate aldolase activity
HPY10_11375	COG0126	phosphoglycerate kinase activity
HPY10_11380	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY10_11385	COG4771	TonB-dependent receptor
HPY10_11390	COG0583	DNA-binding transcription factor activity
HPY10_11395	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY10_11400	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HPY10_11405	COG3091	SprT-like family
HPY10_11410	COG2356	endonuclease I
HPY10_11415	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPY10_11420	COG0189	ligase activity
HPY10_11425	COG1678	Uncharacterized ACR, COG1678
HPY10_11430	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPY10_11435	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY10_11455	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPY10_11460	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPY10_11465	COG0762	integral membrane protein
HPY10_11480	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPY10_11485	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPY10_11490	COG2066	Belongs to the glutaminase family
HPY10_11495	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPY10_11500	COG1194	a g-specific adenine glycosylase
HPY10_11505	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HPY10_11510	COG0741	lytic transglycosylase activity
HPY10_11565	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HPY10_11570	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HPY10_11575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY10_11580	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPY10_11585	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HPY10_11590	COG2967	ApaG domain
HPY10_11595	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPY10_11605	COG3610	response to peptide
HPY10_11610	COG2966	Psort location CytoplasmicMembrane, score
HPY10_11615	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPY10_11620	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HPY10_11625	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPY10_11630	COG0142	geranyltranstransferase activity
HPY10_11635	COG0531	amino acid
HPY10_11640	COG0039	L-malate dehydrogenase activity
HPY10_11645	COG1438	arginine binding
HPY10_11650	COG2358	TRAP transporter, solute receptor (TAXI family
HPY10_11660	COG0589	response to stress
HPY10_11680	COG2235	arginine
HPY10_11685	COG0312	modulator of DNA gyrase
HPY10_11690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPY10_11695	COG3164	Protein of unknown function
HPY10_11700	COG1530	ribonuclease E activity
HPY10_11705	COG0424	maF-like protein
HPY10_11710	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HPY10_11715	COG1792	Involved in formation and maintenance of cell shape
HPY10_11720	COG1077	Cell shape determining protein MreB Mrl
HPY10_11765	COG1459	type II secretion system
HPY10_11770	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY10_11780	COG3409	Peptidoglycan-binding domain 1 protein
HPY10_11780	COG3267	Type II secretory pathway component ExeA
HPY10_11805	COG2199	diguanylate cyclase activity
HPY10_11805	COG2200	EAL domain
HPY10_11810	COG0629	single-stranded DNA binding
HPY10_11825	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPY10_11835	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY10_11840	COG0527	aspartate kinase activity
HPY10_11845	COG0646	methionine synthase
HPY10_11845	COG1410	methionine synthase
HPY10_11920	COG0175	sulfate reduction
HPY10_11930	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY10_11955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY10_11960	COG0735	belongs to the Fur family
HPY10_11975	COG0166	Belongs to the GPI family
HPY10_11980	COG0432	Pfam Uncharacterised protein family UPF0047
HPY10_11985	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY10_12000	COG0359	binds to the 23S rRNA
HPY10_12005	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HPY10_12010	COG2965	DNA replication, synthesis of RNA primer
HPY10_12015	COG0360	Binds together with S18 to 16S ribosomal RNA
HPY10_12025	COG2906	2 iron, 2 sulfur cluster binding
HPY10_12030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY10_12035	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY10_12040	COG0049	tRNA binding
HPY10_12055	COG2923	Belongs to the DsrF TusC family
HPY10_12060	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HPY10_12065	COG2964	Protein conserved in bacteria
HPY10_12070	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY10_12080	COG2900	Belongs to the SlyX family
HPY10_12085	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HPY10_12090	COG0330	HflC and HflK could
HPY10_12095	COG0330	HflC and HflK could
HPY10_12100	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPY10_12105	COG1923	regulation of RNA biosynthetic process
HPY10_12110	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPY10_12115	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPY10_12125	COG0802	atpase or kinase
HPY10_12130	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPY10_12175	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HPY10_12180	COG1162	GTPase activity
HPY10_12185	COG0688	phosphatidylethanolamine metabolic process
HPY10_12190	COG0471	metal ion transport
HPY10_12200	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HPY10_12205	COG4942	peptidase
HPY10_12220	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HPY10_12225	COG2816	NAD+ diphosphatase activity
HPY10_12230	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HPY10_12235	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPY10_12240	COG0085	RNA polymerase activity
HPY10_12245	COG0222	ribosome binding
HPY10_12250	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPY10_12260	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPY10_12265	COG0250	Participates in transcription elongation, termination and antitermination
HPY10_12270	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY10_12275	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY10_12300	COG1072	(Pantothenic acid kinase))
HPY10_12310	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPY10_12320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPY10_12365	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPY10_12380	COG3118	belongs to the thioredoxin family
HPY10_12385	COG0513	Belongs to the DEAD box helicase family
HPY10_12390	COG0248	Ppx GppA phosphatase
HPY10_12395	COG0784	Response regulator, receiver
HPY10_12395	COG2205	protein histidine kinase activity
HPY10_12400	COG2814	Major facilitator Superfamily
HPY10_12415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY10_12420	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HPY10_12425	COG0511	ligase activity, forming carbon-carbon bonds
HPY10_12430	COG0439	Biotin carboxylase
HPY10_12435	COG2264	protein methyltransferase activity
HPY10_12440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY10_12445	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HPY10_12455	COG1609	Transcriptional regulator
HPY10_12465	COG0129	dihydroxy-acid dehydratase activity
HPY10_12470	COG3265	gluconokinase activity
HPY10_12475	COG2610	gluconate transmembrane transporter activity
HPY10_12480	COG0800	Aldolase
HPY10_12500	COG0840	transmembrane signaling receptor activity
HPY10_12505	COG1982	Orn Lys Arg decarboxylase major
HPY10_12510	COG0531	amino acid
HPY10_12515	COG3710	Transcriptional regulator
HPY10_12520	COG0789	Transcriptional regulator
HPY10_12535	COG0151	Belongs to the GarS family
HPY10_12545	COG0776	regulation of translation
HPY10_12550	COG1253	flavin adenine dinucleotide binding
HPY10_12565	COG3068	Protein conserved in bacteria
HPY10_12575	COG1573	uracil-dna glycosylase
HPY10_12580	COG0668	transmembrane transport
HPY10_12585	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HPY10_12595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPY10_12600	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HPY10_12605	COG1482	cell wall glycoprotein biosynthetic process
HPY10_12630	COG0438	transferase activity, transferring glycosyl groups
HPY10_12645	COG1216	Glycosyl transferase, family 2
HPY10_12685	COG1596	polysaccharide export
HPY10_12705	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY10_12715	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY10_12740	COG1215	transferase activity, transferring glycosyl groups
HPY10_12745	COG1132	(ABC) transporter
HPY10_12780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY10_12800	COG0859	PFAM glycosyl transferase family 9
HPY10_12810	COG1519	Transferase
HPY10_12815	COG0456	acetyltransferase
HPY10_12820	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPY10_12835	COG3642	lipopolysaccharide core region biosynthetic process
HPY10_12840	COG0859	PFAM glycosyl transferase family 9
HPY10_12845	COG0463	Glycosyl transferase, family 2
HPY10_12850	COG0859	PFAM glycosyl transferase family 9
HPY10_12855	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPY10_12860	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HPY10_12870	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPY10_12875	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HPY10_12880	COG2003	Belongs to the UPF0758 family
HPY10_12890	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPY10_12900	COG1309	transcriptional regulator
HPY10_12905	COG1560	Kdo2-lipid A biosynthetic process
HPY10_12910	COG1560	Kdo2-lipid A biosynthetic process
HPY10_12915	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPY10_12920	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HPY10_12925	COG1561	YicC-like family, N-terminal region
HPY10_12980	COG0270	DNA (cytosine-5-)-methyltransferase activity
HPY10_13030	COG2862	Uncharacterized protein family, UPF0114
HPY10_13035	COG3385	transposase activity
HPY10_13040	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY10_13045	COG1263	PTS System
HPY10_13045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY10_13050	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY10_13065	COG0514	ATP-dependent DNA helicase (RecQ)
HPY10_13070	COG2962	Rard protein
HPY10_13075	COG0405	Gamma-glutamyltransferase
HPY10_13085	COG1280	lysine exporter protein (LysE YggA)
HPY10_13090	COG0210	DNA helicase
HPY10_13100	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HPY10_13105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY10_13115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY10_13125	COG0747	negative chemotaxis
HPY10_13220	COG4964	Belongs to the GSP D family
HPY10_13255	COG1309	transcriptional regulator
HPY10_13260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY10_13265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY10_13270	COG2960	long-chain fatty acid transporting porin activity
HPY10_13275	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPY10_13280	COG0583	DNA-binding transcription factor activity
HPY10_13345	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HPY10_13350	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY10_13355	COG1739	Uncharacterized protein family UPF0029
HPY10_13360	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY10_13360	COG1024	Enoyl-CoA hydratase
HPY10_13365	COG0183	Belongs to the thiolase family
HPY10_13370	COG0583	DNA-binding transcription factor activity
HPY10_13375	COG2814	Major facilitator Superfamily
HPY10_13385	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPY10_13390	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HPY10_13395	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPY10_13400	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPY10_13405	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPY10_13410	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HPY10_13420	COG0356	it plays a direct role in the translocation of protons across the membrane
HPY10_13425	COG3312	ion transport
HPY10_13430	COG1475	DNA binding
HPY10_13435	COG1192	Involved in chromosome partitioning
HPY10_13440	COG0357	Ribosomal RNA small subunit methyltransferase G
HPY10_13445	COG0445	tRNA wobble uridine modification
HPY10_13450	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY10_13550	COG4974	Belongs to the 'phage' integrase family
HPY10_13555	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPY10_13560	COG0706	membrane insertase activity
HPY10_13570	COG0594	ribonuclease P activity
HPY10_13575	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPY10_13580	COG1126	abc transporter atp-binding protein
HPY10_13625	COG0217	transcriptional regulatory protein
HPY10_13630	COG2084	Dehydrogenase
HPY10_13645	COG2909	trisaccharide binding
HPY10_13650	COG0058	SHG alpha-glucan phosphorylase activity
HPY10_13655	COG1640	4-alpha-glucanotransferase
HPY10_13660	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HPY10_13670	COG3501	Rhs element vgr protein
HPY10_13705	COG0471	metal ion transport
HPY10_13710	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY10_13740	COG0671	phosphoesterase, PA-phosphatase related
HPY10_13750	COG3385	transposase activity
HPY10_13755	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HPY10_13765	COG1999	signal sequence binding
HPY10_13780	COG0786	glutamate:sodium symporter activity
HPY10_13800	COG1566	PFAM secretion protein HlyD family protein
HPY10_13810	COG3706	GGDEF domain
HPY10_13825	COG0813	purine-nucleoside phosphorylase activity
HPY10_13830	COG3272	Protein of unknown function (DUF1722)
HPY10_13840	COG0415	Belongs to the DNA photolyase family
HPY10_13845	COG1376	ErfK ybiS ycfS ynhG family protein
HPY10_13845	COG1388	LysM domain
HPY10_13855	COG0513	Belongs to the DEAD box helicase family
HPY10_13860	COG1770	oligopeptidase
HPY10_13890	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY10_13895	COG0573	inorganic phosphate transmembrane transporter activity
HPY10_13900	COG0581	inorganic phosphate transmembrane transporter activity
HPY10_13905	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY10_13925	COG0659	secondary active sulfate transmembrane transporter activity
HPY10_13935	COG0739	heme binding
HPY10_13940	COG5001	Diguanylate cyclase
HPY10_13940	COG3300	MHYT domain
HPY10_13945	COG0583	DNA-binding transcription factor activity
HPY10_13950	COG2814	Major facilitator Superfamily
HPY10_13970	COG1301	dicarboxylic acid transport
HPY10_13985	COG1342	Belongs to the UPF0251 family
HPY10_14015	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPY10_14020	COG0673	inositol 2-dehydrogenase activity
HPY10_14030	COG2771	luxR family
HPY10_14030	COG2200	EAL domain
HPY10_14035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY10_14045	COG0564	pseudouridine synthase activity
HPY10_14150	COG1869	D-ribose catabolic process
HPY10_14155	COG1129	ABC transporter
HPY10_14160	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPY10_14165	COG1879	ABC-type sugar transport system periplasmic component
HPY10_14170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY10_14175	COG1609	Transcriptional regulator
HPY10_14185	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY10_14195	COG0584	glycerophosphoryl diester phosphodiesterase
HPY10_14200	COG2271	Major facilitator Superfamily
HPY10_14235	COG0579	oxidoreductase
HPY10_14245	COG0242	peptide deformylase activity
HPY10_14250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY10_14250	COG1017	nitric oxide dioxygenase activity
HPY10_14255	COG1320	monovalent cation:proton antiporter activity
HPY10_14260	COG2212	antiporter activity
HPY10_14280	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY10_14280	COG2111	Na H antiporter
HPY10_14290	COG0589	response to stress
HPY10_14295	COG0814	amino acid
HPY10_14310	COG3530	Putative quorum-sensing-regulated virulence factor
HPY10_14320	COG5001	Diguanylate cyclase
HPY10_14320	COG5002	protein histidine kinase activity
HPY10_14325	COG1278	Cold shock
HPY10_14340	COG2304	oxidoreductase activity
HPY10_14360	COG0714	Associated with various cellular activities
HPY10_14365	COG0840	transmembrane signaling receptor activity
HPY10_14380	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY10_14385	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY10_14395	COG3604	Transcriptional regulator
HPY10_14400	COG1017	nitric oxide dioxygenase activity
HPY10_14400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY10_14405	COG1278	Cold shock
HPY10_14410	COG3036	rescue of stalled ribosome
HPY10_14435	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPY10_14435	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPY10_14440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY10_14450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY10_14460	COG0516	GMP reductase activity
HPY10_14465	COG1204	response to ionizing radiation
HPY10_14475	COG0513	Belongs to the DEAD box helicase family
HPY10_14480	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY10_14485	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HPY10_14495	COG0784	Response regulator, receiver
HPY10_14495	COG3437	response regulator, receiver
HPY10_14500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY10_14500	COG4191	Histidine kinase
HPY10_14510	COG1757	Na H antiporter
HPY10_14515	COG2814	Major facilitator Superfamily
HPY10_14525	COG3706	GGDEF domain
HPY10_14530	COG3240	lipase activity
HPY10_14545	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HPY10_14550	COG5380	lipid catabolic process
HPY10_14575	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY10_14580	COG4605	iron ion homeostasis
HPY10_14585	COG4604	ABC transporter, ATP-binding protein
HPY10_14590	COG2207	Transcriptional regulator
HPY10_14605	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY10_14620	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPY10_14630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY10_14640	COG0583	DNA-binding transcription factor activity
HPY10_14655	COG0745	RESPONSE REGULATOR receiver
HPY10_14665	COG3623	hexulose-6-phosphate isomerase
HPY10_14670	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HPY10_14675	COG0561	phosphatase activity
HPY10_14710	COG0366	Alpha amylase catalytic
HPY10_14730	COG0745	RESPONSE REGULATOR receiver
HPY10_14735	COG5002	protein histidine kinase activity
HPY10_14780	COG1686	Belongs to the peptidase S11 family
HPY10_14800	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY10_14800	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY10_14805	COG0509	glycine decarboxylation via glycine cleavage system
HPY10_14810	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY10_14820	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HPY10_14835	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HPY10_14840	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPY10_15065	COG0384	phenazine biosynthesis protein PhzF
HPY10_15190	COG0384	phenazine biosynthesis protein PhzF
HPY10_15200	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPY10_15280	COG1028	Short-chain dehydrogenase reductase Sdr
HPY10_15395	COG1011	Hydrolase
HPY10_15475	COG3041	Addiction module toxin RelE StbE family
HPY10_15485	COG0384	phenazine biosynthesis protein PhzF
HPY10_15490	COG0346	lactoylglutathione lyase activity
HPY10_15545	COG3171	Protein conserved in bacteria
HPY10_15605	COG0384	phenazine biosynthesis protein PhzF
HPY10_15905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY10_16100	COG0346	lactoylglutathione lyase activity
HPY10_16125	COG3040	lipid binding
HPY10_16140	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPY10_16245	COG0456	acetyltransferase
HPY10_16290	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY10_16290	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY10_16295	COG0494	nUDIX hydrolase
HPY10_16320	COG1028	Short-chain dehydrogenase reductase Sdr
HPY10_16335	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPY10_16370	COG0384	phenazine biosynthesis protein PhzF
HPY10_16530	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPY10_16555	COG0384	phenazine biosynthesis protein PhzF
HPY10_16565	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HPY10_16570	COG2944	sequence-specific DNA binding
HPY10_16635	COG0346	lactoylglutathione lyase activity
HPY10_16670	COG0384	phenazine biosynthesis protein PhzF
HPY10_16695	COG5642	Protein of unknown function (DUF2384)
HPY10_16700	COG0384	phenazine biosynthesis protein PhzF
HPY10_16720	COG0494	nUDIX hydrolase
HPY10_16725	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPY10_16735	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY10_16735	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY10_16765	COG3040	lipid binding
HPY10_16815	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY10_16830	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY10_16835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY10_16840	COG1621	beta-fructofuranosidase activity
HPY10_16850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY10_16850	COG1263	PTS System
HPY10_16895	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY10_16930	COG0778	Nitroreductase
HPY10_16935	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HPY10_16940	COG0583	DNA-binding transcription factor activity
HPY10_16965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY10_17000	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY10_17010	COG2390	Transcriptional regulator
HPY10_17020	COG2897	thiosulfate sulfurtransferase activity
HPY10_17030	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY10_17040	COG0302	gtp cyclohydrolase
HPY10_17045	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY10_17045	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY10_17050	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HPY10_17055	COG1970	mechanosensitive ion channel activity
HPY10_17060	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HPY10_17070	COG1011	Hydrolase
HPY10_17075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY10_17080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY10_17090	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY10_17100	COG3842	ATPase activity
HPY10_17120	COG3104	oligopeptide transport
HPY10_17145	COG4166	transmembrane transport
HPY10_17150	COG4174	ABC transporter (Permease)
HPY10_17155	COG4239	(ABC) transporter, permease
HPY10_17160	COG4172	Belongs to the ABC transporter superfamily
HPY10_17165	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPY10_17180	COG0625	glutathione transferase activity
HPY10_17200	COG2050	protein possibly involved in aromatic compounds catabolism
HPY10_17215	COG4771	TonB-dependent receptor
HPY10_17215	COG1629	transport
HPY10_17220	COG0583	DNA-binding transcription factor activity
HPY10_17225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY10_17225	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY10_17225	COG1042	CoA-binding domain protein
HPY10_17245	COG0023	Translation Initiation Factor
HPY10_17250	COG3140	Belongs to the UPF0181 family
HPY10_17265	COG0745	RESPONSE REGULATOR receiver
HPY10_17275	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HPY10_17280	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HPY10_17295	COG3706	GGDEF domain
HPY10_17350	COG2824	Alkylphosphonate utilization operon protein PhnA
HPY10_17355	COG3385	transposase activity
HPY10_17370	COG0737	Belongs to the 5'-nucleotidase family
HPY10_17375	COG3593	DNA synthesis involved in DNA repair
HPY10_17385	COG0583	DNA-binding transcription factor activity
HPY10_17390	COG2116	formate transmembrane transporter activity
HPY10_17400	COG3038	cytochrome b561
HPY10_17410	COG2200	EAL domain
HPY10_17425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY10_17430	COG0745	RESPONSE REGULATOR receiver
HPY10_17435	COG2205	protein histidine kinase activity
HPY10_17440	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPY10_17440	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPY10_17440	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPY10_17440	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPY10_17445	COG3158	transport of potassium into the cell
HPY10_17455	COG0523	cobalamin synthesis protein
HPY10_17470	COG0156	8-amino-7-oxononanoate synthase activity
HPY10_17475	COG2205	protein histidine kinase activity
HPY10_17475	COG0784	Response regulator, receiver
HPY10_17480	COG0419	ATPase involved in DNA repair
HPY10_17485	COG0420	3'-5' exonuclease activity
HPY10_17490	COG1609	Transcriptional regulator
HPY10_17495	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY10_17495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY10_17500	COG1105	Belongs to the carbohydrate kinase PfkB family
HPY10_17505	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY10_17505	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HPY10_17505	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY10_17510	COG4067	protein conserved in archaea
HPY10_17510	COG0189	ligase activity
HPY10_17520	COG0602	queuosine metabolic process
HPY10_17525	COG1328	CTP reductase activity
HPY10_17535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY10_17540	COG0840	transmembrane signaling receptor activity
HPY10_17545	COG3069	C4-dicarboxylate transmembrane transporter activity
HPY10_17550	COG1760	l-serine dehydratase
HPY10_17555	COG2197	response regulator
HPY10_17560	COG3850	Histidine kinase
HPY10_17565	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY10_17575	COG0243	molybdopterin cofactor binding
HPY10_17595	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY10_17600	COG2197	response regulator
HPY10_17605	COG3851	Histidine kinase
HPY10_17610	COG2271	Major facilitator Superfamily
HPY10_17615	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY10_17625	COG3842	ATPase activity
HPY10_17630	COG3243	poly(R)-hydroxyalkanoic acid synthase
HPY10_17640	COG0183	Belongs to the thiolase family
HPY10_17650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY10_17655	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY10_17670	COG3706	GGDEF domain
HPY10_17675	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY10_17685	COG1979	alcohol dehydrogenase
HPY10_17700	COG4191	Histidine kinase
HPY10_17710	COG2271	Major facilitator Superfamily
HPY10_17715	COG0469	pyruvate kinase activity
HPY10_17725	COG1879	ABC-type sugar transport system periplasmic component
HPY10_17730	COG1803	Methylglyoxal synthase
HPY10_17735	COG1335	isochorismatase
HPY10_17740	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPY10_17745	COG0210	DNA helicase
HPY10_17750	COG1289	transmembrane transporter activity
HPY10_17780	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HPY10_17785	COG4149	molybdate abc transporter
HPY10_17790	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPY10_17795	COG1492	cobalamin metabolic process
HPY10_17835	COG4977	sequence-specific DNA binding
HPY10_17835	COG1917	Cupin 2, conserved barrel domain protein
HPY10_17845	COG2814	Major facilitator Superfamily
HPY10_17850	COG3433	isochorismatase activity
HPY10_17850	COG2226	methyltransferase
HPY10_17850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY10_17875	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY10_17880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY10_17900	COG1132	(ABC) transporter
HPY10_17905	COG1132	(ABC) transporter
HPY10_17915	COG0784	Response regulator, receiver
HPY10_17915	COG5002	protein histidine kinase activity
HPY10_17920	COG1879	ABC-type sugar transport system periplasmic component
HPY10_17930	COG2827	Endonuclease containing a URI domain
HPY10_17945	COG2926	Belongs to the UPF0265 family
HPY10_17955	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HPY10_17960	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPY10_17970	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HPY10_17975	COG0247	lactate metabolic process
HPY10_17980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY10_17985	COG3118	belongs to the thioredoxin family
HPY10_18010	COG4160	amino acid transport
HPY10_18015	COG4215	(ABC) transporter
HPY10_18020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY10_18025	COG1126	abc transporter atp-binding protein
HPY10_18035	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HPY10_18045	COG0494	nUDIX hydrolase
HPY10_18050	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HPY10_18060	COG1309	transcriptional regulator
HPY10_18065	COG0513	Belongs to the DEAD box helicase family
HPY10_18070	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HPY10_18075	COG0814	amino acid
HPY10_18080	COG0840	transmembrane signaling receptor activity
HPY10_18085	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPY10_18100	COG1984	allophanate hydrolase subunit 2
HPY10_18115	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HPY10_18120	COG4181	ATPase activity
HPY10_18130	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY10_18135	COG1716	ATPase activity
HPY10_18135	COG5001	Diguanylate cyclase
HPY10_18145	COG0484	heat shock protein binding
HPY10_18160	COG0546	phosphoglycolate phosphatase activity
HPY10_18175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY10_18180	COG1368	sulfuric ester hydrolase activity
HPY10_18190	COG0513	Belongs to the DEAD box helicase family
HPY10_18205	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY10_18215	COG3046	protein related to deoxyribodipyrimidine photolyase
HPY10_18220	COG3397	chitin binding
HPY10_18225	COG3227	Zinc metalloprotease (Elastase)
HPY10_18240	COG1166	arginine decarboxylase activity
HPY10_18250	COG2239	Acts as a magnesium transporter
HPY10_18260	COG0527	aspartate kinase activity
HPY10_18270	COG2154	pterin-4-alpha-carbinolamine dehydratase
HPY10_18275	COG3186	Phenylalanine-4-hydroxylase
HPY10_18280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY10_18295	COG2264	protein methyltransferase activity
HPY10_18320	COG1253	flavin adenine dinucleotide binding
HPY10_18325	COG1765	OsmC-like protein
HPY10_18350	COG0531	amino acid
HPY10_18355	COG3706	GGDEF domain
HPY10_18365	COG4989	oxidoreductase activity
HPY10_18370	COG0366	Alpha amylase catalytic
HPY10_18380	COG2067	long-chain fatty acid transport protein
HPY10_18385	COG2267	carboxylic ester hydrolase activity
HPY10_18395	COG3227	Zinc metalloprotease (Elastase)
HPY10_18400	COG3047	cAMP biosynthetic process
HPY10_18410	COG1686	Belongs to the peptidase S11 family
HPY10_18415	COG0557	exoribonuclease II activity
HPY10_18420	COG1278	Cold shock
HPY10_18430	COG3048	D-serine ammonia-lyase activity
HPY10_18435	COG0583	DNA-binding transcription factor activity
HPY10_18455	COG2801	Transposase and inactivated derivatives
HPY10_18460	COG5002	protein histidine kinase activity
HPY10_18485	COG0582	viral genome integration into host DNA
HPY10_18505	COG1063	alcohol dehydrogenase
HPY10_18510	COG0156	8-amino-7-oxononanoate synthase activity
HPY10_18515	COG2873	o-acetylhomoserine
HPY10_18525	COG0346	lactoylglutathione lyase activity
HPY10_18550	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY10_18555	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPY10_18560	COG0363	glucosamine-6-phosphate deaminase activity
HPY10_18565	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPY10_18600	COG1929	Belongs to the glycerate kinase type-1 family
HPY10_18605	COG2610	gluconate transmembrane transporter activity
HPY10_18610	COG3835	regulator
HPY10_18620	COG0748	coenzyme F420 binding
HPY10_18625	COG3721	Heme iron utilization protein
HPY10_18635	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY10_18640	COG0811	peptide transport
HPY10_18645	COG0848	biopolymer transport protein
HPY10_18650	COG4558	Periplasmic binding protein
HPY10_18655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY10_18660	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPY10_18695	COG0633	Ferredoxin
HPY10_18695	COG3217	Mosc domain protein beta barrel domain protein
HPY10_18695	COG0633	Ferredoxin
HPY10_18695	COG3217	Mosc domain protein beta barrel domain protein
HPY10_18700	COG0418	dihydroorotase activity
HPY10_18705	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY10_18710	COG2354	Protein conserved in bacteria
HPY10_18720	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY10_18725	COG1278	Cold shock
HPY10_18750	COG3706	GGDEF domain
HPY10_18755	COG1349	DNA-binding transcription factor activity
HPY10_18770	COG3833	ABC-type maltose transport systems, permease component
HPY10_18775	COG1175	transmembrane transport
HPY10_18785	COG3842	ATPase activity
HPY10_18790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY10_18805	COG0393	Putative heavy-metal-binding
HPY10_18815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY10_18820	COG0784	Response regulator, receiver
HPY10_18820	COG0835	chemotaxis
HPY10_18825	COG1846	Transcriptional regulator
HPY10_18830	COG3706	GGDEF domain
HPY10_18865	COG0583	DNA-binding transcription factor activity
HPY10_18870	COG5001	Diguanylate cyclase
HPY10_18880	COG1741	Belongs to the pirin family
HPY10_18885	COG3123	guanosine phosphorylase activity
HPY10_18895	COG2211	Major facilitator Superfamily
HPY10_18900	COG0840	transmembrane signaling receptor activity
HPY10_18905	COG1067	ATP-dependent peptidase activity
HPY10_18915	COG4172	Belongs to the ABC transporter superfamily
HPY10_18935	COG0583	DNA-binding transcription factor activity
HPY10_18945	COG1620	l-lactate permease
HPY10_18960	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HPY10_18970	COG0840	transmembrane signaling receptor activity
HPY10_18990	COG2258	MOSC domain
HPY10_18995	COG0513	Belongs to the DEAD box helicase family
HPY10_19005	COG2186	Transcriptional regulator
HPY10_19015	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY10_19025	COG0246	Mannitol dehydrogenase
HPY10_19030	COG1904	glucuronate isomerase
HPY10_19035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY10_19040	COG0800	Aldolase
HPY10_19050	COG0583	DNA-binding transcription factor activity
HPY10_19060	COG1902	pentaerythritol trinitrate reductase activity
HPY10_19070	COG1132	(ABC) transporter
HPY10_19080	COG1902	pentaerythritol trinitrate reductase activity
HPY10_19090	COG1280	lysine exporter protein (LysE YggA)
HPY10_19095	COG2207	Transcriptional regulator
HPY10_19115	COG1846	Transcriptional regulator
HPY10_19120	COG1764	response to oxidative stress
HPY10_19125	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY10_19130	COG0697	spore germination
HPY10_19140	COG0700	Nucleoside recognition
HPY10_19145	COG3366	ferrous iron transmembrane transporter activity
HPY10_19150	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPY10_19160	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPY10_19165	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPY10_19170	COG2259	Doxx family
HPY10_19195	COG0363	glucosamine-6-phosphate deaminase activity
HPY10_19210	COG4580	involved in the transport of maltose and maltodextrins
HPY10_19225	COG0840	transmembrane signaling receptor activity
HPY10_19235	COG0840	transmembrane signaling receptor activity
HPY10_19240	COG3706	GGDEF domain
HPY10_19250	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY10_19255	COG1126	abc transporter atp-binding protein
HPY10_19265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY10_19270	COG4597	amino acid ABC transporter
HPY10_19275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPY10_19280	COG2213	PTS system mannitol-specific
HPY10_19280	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY10_19285	COG0246	Mannitol dehydrogenase
HPY10_19290	COG3722	fumarate hydratase activity
HPY10_19325	COG2910	NAD(P)H-binding
HPY10_19335	COG0840	transmembrane signaling receptor activity
HPY10_19340	COG4221	oxidoreductase activity
HPY10_19350	COG1901	pseudouridine methyltransferase
HPY10_19365	COG0531	amino acid
HPY10_19370	COG1982	Orn Lys Arg decarboxylase major
HPY10_19380	COG2197	response regulator
HPY10_19430	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY10_19455	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPY10_19520	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY10_19525	COG0840	transmembrane signaling receptor activity
HPY10_19530	COG0835	chemotaxis
HPY10_19535	COG0835	chemotaxis
HPY10_19540	COG2198	Histidine kinase
HPY10_19540	COG0643	Histidine kinase
HPY10_19560	COG0601	transmembrane transport
HPY10_19565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY10_19570	COG4608	Belongs to the ABC transporter superfamily
HPY10_19575	COG1444	tRNA N-acetyltransferase activity
HPY10_19580	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY10_19585	COG2974	May be involved in recombination
HPY10_19680	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPY10_20020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair