locus-tag class description ASZ79_00001 ENOG4105QTB Flavodoxin ASZ79_00002 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) ASZ79_00003 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins ASZ79_00004 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) ASZ79_00007 ENOG4105E5Q amino acid AbC transporter ASZ79_00008 ENOG4105EAB amino acid AbC transporter ASZ79_00010 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) ASZ79_00011 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) ASZ79_00012 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) ASZ79_00013 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ASZ79_00016 ENOG4108ZNX Heat shock protein ASZ79_00017 ENOG4105JKW Valine--pyruvate aminotransferase ASZ79_00018 ENOG4105C38 Glycyl-tRNA synthetase beta subunit ASZ79_00019 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit ASZ79_00022 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) ASZ79_00024 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family ASZ79_00025 ENOG4105C7B Threonine dehydratase ASZ79_00026 ENOG4105C01 Dihydroxy-acid dehydratase ASZ79_00027 ENOG4105CM2 brancheD-chain amino acid aminotransferase ASZ79_00030 ENOG4105C0P Mg chelatase subunit ChlI ASZ79_00031 ENOG4106HNH Acyl-transferase ASZ79_00032 ENOG4108Z33 Thiol disulfide Interchange Protein ASZ79_00033 ENOG4105E27 serine threonine protein kinase ASZ79_00035 ENOG4105PC1 Conserved Protein ASZ79_00037 ENOG4108N23 SpoOM-related protein ASZ79_00038 ENOG4108UT2 hemolysin iii ASZ79_00040 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) ASZ79_00041 ENOG4105C1A potassium transporter peripheral membrane ASZ79_00042 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B ASZ79_00043 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) ASZ79_00044 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) ASZ79_00045 ENOG4108WZM domain protein ASZ79_00046 ENOG4105C79 DNA protecting protein DprA ASZ79_00047 ENOG4108RPN Protein smg homolog ASZ79_00048 ENOG4108WI1 Dna topoisomerase ASZ79_00049 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit ASZ79_00050 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) ASZ79_00051 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) ASZ79_00052 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) ASZ79_00053 ENOG4105E2X shikimate dehydrogenase ASZ79_00055 ENOG4108Z0R Transferase ASZ79_00063 ENOG4105WMR Protein CrcB homolog ASZ79_00064 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) ASZ79_00066 ENOG4105D06 uba thif-type nad fad binding protein ASZ79_00067 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) ASZ79_00068 ENOG4105D41 biosynthesis protein thiH ASZ79_00069 ENOG4105DC7 peptidase M24 ASZ79_00069 ENOG4105DC7 peptidase M24 ASZ79_00071 ENOG4105CNH Multidrug resistance protein MdtL ASZ79_00073 ENOG4108VVK transcriptional Regulator, AsnC ASZ79_00074 ENOG4105BZU Histidine kinase ASZ79_00075 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) ASZ79_00077 ENOG4105EMK carboxylate amino acid amine transporter ASZ79_00078 ENOG4108M6U Universal stress protein A ASZ79_00079 ENOG41090A1 ferritin ASZ79_00080 ENOG4108V6B universal stress protein B ASZ79_00081 ENOG4105CBX hi0933 family ASZ79_00083 ENOG4105CGY Dna recombination protein ASZ79_00084 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) ASZ79_00085 ENOG4105JC1 sterol-binding domain protein ASZ79_00086 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) ASZ79_00087 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) ASZ79_00088 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) ASZ79_00089 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) ASZ79_00090 ENOG4105CA0 peroxidase ASZ79_00091 ENOG4107R73 Mate efflux family protein ASZ79_00093 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) ASZ79_00094 ENOG4105E55 glycerol-3-phosphate acyltransferase ASZ79_00095 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) ASZ79_00096 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) ASZ79_00097 ENOG4105X6C Flagellar basal body-associated protein FliL ASZ79_00098 ENOG4105C8Q Methyl-accepting chemotaxis ASZ79_00100 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) ASZ79_00101 ENOG4105F8V Hydrolase, tatD family ASZ79_00103 ENOG4105D52 delta-aminolevulinic acid dehydratase ASZ79_00105 ENOG4105C2M dna polymerase I ASZ79_00107 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) ASZ79_00108 ENOG4106RE7 Cytochrome ASZ79_00110 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) ASZ79_00111 ENOG4105XCT Protein of unknown function (DUF2489) ASZ79_00112 ENOG4105D4P Coproporphyrinogen iii oxidase ASZ79_00113 ENOG410601J HemY protein ASZ79_00114 ENOG4105ECF c-methyltransferase ASZ79_00115 ENOG41076E6 Uroporphyrinogen-III Synthase ASZ79_00116 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) ASZ79_00117 ENOG4107T0K Adenylate cyclase ASZ79_00118 ENOG4105XQ6 frataxin-like protein ASZ79_00120 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) ASZ79_00121 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) ASZ79_00122 ENOG4105CT0 Protein of unknown function, DUF484 ASZ79_00123 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ASZ79_00124 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant ASZ79_00125 ENOG4105BZU Histidine kinase ASZ79_00128 ENOG4105DQF Hydrolase ASZ79_00129 ENOG4108EUD Lysophospholipase ASZ79_00130 ENOG410829K Lysine exporter protein (Lyse ygga) ASZ79_00131 ENOG4105D58 Diguanylate phosphodiesterase ASZ79_00132 ENOG4108RMU ferritin dps family protein ASZ79_00138 ENOG4106H78 methyltransferase ASZ79_00139 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ASZ79_00140 ENOG4105CAK Cell division ATP-binding protein ftsE ASZ79_00141 ENOG4105CRP Part of the ABC transporter FtsEX involved in ASZ79_00142 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ASZ79_00143 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) ASZ79_00146 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) ASZ79_00147 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) ASZ79_00148 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin ASZ79_00149 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) ASZ79_00161 ENOG4105EMY transcriptional regulator ASZ79_00162 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase ASZ79_00163 ENOG4105W0Z cytoplasmic protein ASZ79_00164 ENOG4105BZS acriflavin resistance protein ASZ79_00165 ENOG410624X efflux transporter, rnd family, mfp subunit ASZ79_00166 ENOG4105Y7M Transcriptional regulator, TetR family ASZ79_00167 ENOG4105C4R Atp-dependent dna helicase ASZ79_00168 ENOG4105MPD Cytochrome ASZ79_00175 ENOG4105DEF Extracellular solute-binding protein, family 5 ASZ79_00176 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ASZ79_00177 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ASZ79_00179 ENOG4108UK2 deaminase ASZ79_00183 ENOG4108ZXE ASZ79_00189 ENOG4105DC8 reductase ASZ79_00190 ENOG4105D6S protein involved in catabolism of external DNA ASZ79_00191 ENOG4105DGW oligopeptidase A ASZ79_00192 ENOG4105C4R Atp-dependent dna helicase ASZ79_00194 ENOG4108DMH HTH_ARAC ASZ79_00196 ENOG4105FR1 rard protein ASZ79_00198 ENOG4105C9U ATP-dependent DNA helicase RecQ ASZ79_00201 ENOG4105BZ1 (ABC) transporter ASZ79_00202 ENOG4105E0K tonB-dependent siderophore receptor ASZ79_00203 ENOG4105E0A ABC, transporter ASZ79_00204 ENOG4105J76 Periplasmic binding protein ASZ79_00205 ENOG4105S6R Iron-hydroxamate transporter permease subunit ASZ79_00206 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) ASZ79_00207 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate ASZ79_00208 ENOG4105C5Y PTS System ASZ79_00210 ENOG4105DSJ YicC domain protein ASZ79_00211 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) ASZ79_00212 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) ASZ79_00213 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase ASZ79_00214 ENOG4105D1S lipid A biosynthesis ASZ79_00215 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) ASZ79_00217 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase ASZ79_00218 ENOG4105C8Q Methyl-accepting chemotaxis ASZ79_00221 ENOG4105KDC 50s ribosomal protein l28 ASZ79_00222 ENOG4105W0E 50S ribosomal protein L33 ASZ79_00224 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) ASZ79_00225 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) ASZ79_00226 ENOG4105M5K heptosyltransferase ASZ79_00227 ENOG4106WTF Glycosyl transferase, family 2 ASZ79_00228 ENOG4105DKP glycosyl transferase, family 9 ASZ79_00229 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) ASZ79_00235 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase ASZ79_00236 ENOG4108ST3 glycosyltransferase ASZ79_00238 ENOG4105XA0 heptosyltransferase ii ASZ79_00241 ENOG4107T94 Endo-14-beta-xylanase ASZ79_00242 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) ASZ79_00243 ENOG4105CJT Mannose-1-phosphate guanylyltransferase ASZ79_00244 ENOG4107QKV phosphomannomutase ASZ79_00245 ENOG4105C0K Gdp-mannose 4,6-dehydratase ASZ79_00246 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase ASZ79_00249 ENOG4105EY8 ABC transporter ASZ79_00251 ENOG4105CEY Amp-dependent synthetase and ligase ASZ79_00252 ENOG4108EKI Dehydrogenase ASZ79_00254 ENOG4108UT6 Transferase hexapeptide repeat containing protein ASZ79_00255 ENOG410600T transposase ASZ79_00256 ENOG410600T transposase ASZ79_00261 ENOG4105D3Q Sugar transferase ASZ79_00263 ENOG4105CY0 Metallo-Beta-Lactamase ASZ79_00264 ENOG4105CUY Mechanosensitive ion channel ASZ79_00265 ENOG4108RG0 uracil-dna glycosylase ASZ79_00266 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase ASZ79_00267 ENOG4105R2J Conserved Protein ASZ79_00268 ENOG4105EIP mannose-6-phosphate isomerase ASZ79_00269 ENOG4105DKQ ROK family ASZ79_00271 ENOG4105K70 DNA-binding protein ASZ79_00273 ENOG4105C12 Phosphoribosylglycinamide synthetase ASZ79_00274 ENOG4105DC1 bifunctional purine biosynthesis protein purh ASZ79_00276 ENOG4105W1Y Transcriptional regulator ASZ79_00277 ENOG4108M3R transcriptional activator CadC ASZ79_00279 ENOG4105D5Q Arginine ornithine antiporter ASZ79_00280 ENOG4105CXN decarboxylase ASZ79_00281 ENOG4105C8Q Methyl-accepting chemotaxis ASZ79_00284 ENOG4105E0K tonB-dependent siderophore receptor ASZ79_00285 ENOG4108UHU Aldolase ASZ79_00286 ENOG4105C6Z Gluconate ASZ79_00287 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family ASZ79_00288 ENOG4105C01 Dihydroxy-acid dehydratase ASZ79_00289 ENOG4105DIQ Transcriptional regulator ASZ79_00290 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) ASZ79_00291 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) ASZ79_00292 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) ASZ79_00293 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase ASZ79_00294 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein ASZ79_00295 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) ASZ79_00296 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ASZ79_00299 ENOG4105D8G Major Facilitator superfamily ASZ79_00300 ENOG4105BZU Histidine kinase ASZ79_00301 ENOG4105C9X ppx gppa phosphatase ASZ79_00302 ENOG4105C1J atp-dependent rna helicase ASZ79_00303 ENOG4105K63 Thioredoxin ASZ79_00304 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) ASZ79_00306 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) ASZ79_00308 ENOG4107QK7 reductase ASZ79_00315 ENOG4105JIM Phosphatidylserine synthase ASZ79_00317 ENOG4105D4A Cell wall formation (By similarity) ASZ79_00318 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase ASZ79_00319 ENOG4105CS9 pantothenic acid kinase ASZ79_00324 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) ASZ79_00325 ENOG4105PM1 preprotein translocase subunit SecE ASZ79_00326 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) ASZ79_00327 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) ASZ79_00328 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) ASZ79_00329 ENOG4108VZM 50s ribosomal protein L10 ASZ79_00330 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) ASZ79_00331 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ASZ79_00332 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ASZ79_00333 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor ASZ79_00334 ENOG4105E09 nadh pyrophosphatase ASZ79_00335 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) ASZ79_00336 ENOG41062JF Transcriptional regulator ASZ79_00338 ENOG41063SB peptidase ASZ79_00339 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) ASZ79_00341 ENOG4105C8P )-transporter ASZ79_00342 ENOG4105DJ4 phosphatidylserine decarboxylase ASZ79_00343 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) ASZ79_00344 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) ASZ79_00354 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) ASZ79_00355 ENOG4105K8N protein family UPF0079, ATPase ASZ79_00356 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase ASZ79_00357 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) ASZ79_00358 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) ASZ79_00359 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) ASZ79_00360 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) ASZ79_00361 ENOG4107QJR hflk protein ASZ79_00362 ENOG4105EPW hflc protein ASZ79_00364 ENOG41069P5 Protein slyX homolog ASZ79_00367 ENOG4108V1T peptidylprolyl cis-trans isomerase ASZ79_00368 ENOG4105WWK YheO domain protein ASZ79_00369 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) ASZ79_00370 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) ASZ79_00372 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) ASZ79_00373 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) ASZ79_00374 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) ASZ79_00375 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) ASZ79_00376 ENOG4105W53 bacterioferritin-associated ferredoxin ASZ79_00377 ENOG4108UQY Iron-storage protein ASZ79_00378 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) ASZ79_00379 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) ASZ79_00380 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) ASZ79_00381 ENOG4105K9Q Binds to the 23S rRNA (By similarity) ASZ79_00383 ENOG4105CDU Replicative dna helicase ASZ79_00384 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ASZ79_00385 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme ASZ79_00386 ENOG4107QP8 phosphohexose isomerase ASZ79_00389 ENOG4105MYN Zinc uptake regulation protein ASZ79_00390 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) ASZ79_00392 ENOG4105P4Z Phage shock protein G ASZ79_00396 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) ASZ79_00397 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) ASZ79_00398 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) ASZ79_00411 ENOG4105EEQ Na H antiporter ASZ79_00412 ENOG4105C3R Methionine synthase ASZ79_00413 ENOG4105CFH Aspartokinase ASZ79_00414 ENOG4105C5R Aminotransferase ASZ79_00416 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) ASZ79_00417 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase ASZ79_00418 ENOG41086KC Transcriptional regulator ASZ79_00419 ENOG4108UUM single-stranded DNA-binding protein ASZ79_00420 ENOG41062P1 Diguanylate cyclase phosphodiesterase ASZ79_00424 ENOG4105E4G Type IV pilus ASZ79_00427 ENOG4107QHF type ii secretion system protein e ASZ79_00428 ENOG4105D7Q type ii secretion system ASZ79_00437 ENOG4105DFF Rod shape-determining protein mreb ASZ79_00438 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) ASZ79_00439 ENOG4105VQ7 Rod shape-determining protein MreD ASZ79_00440 ENOG4108Z03 MAF-like protein ASZ79_00441 ENOG4105C03 ribonuclease ASZ79_00442 ENOG4105QD6 exported protein ASZ79_00444 ENOG4105D1U peptidase U62 modulator of DNA gyrase ASZ79_00445 ENOG4105CEU Arginine dihydrolase ASZ79_00449 ENOG41081QV Universal stress protein ASZ79_00452 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) ASZ79_00453 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) ASZ79_00454 ENOG4105D5Q Arginine ornithine antiporter ASZ79_00455 ENOG4105EAH synthase ASZ79_00456 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) ASZ79_00457 ENOG4105K46 50S ribosomal protein l27 ASZ79_00458 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control ASZ79_00459 ENOG4105DWK Membrane ASZ79_00460 ENOG4107XM3 UPF0442 protein ASZ79_00462 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) ASZ79_00463 ENOG4105NWN ApaG protein ASZ79_00464 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) ASZ79_00465 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) ASZ79_00466 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) ASZ79_00467 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) ASZ79_00468 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) ASZ79_00479 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division ASZ79_00480 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) ASZ79_00481 ENOG4105CEN a g-specific adenine glycosylase ASZ79_00483 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) ASZ79_00484 ENOG4105CSV Glutaminase ASZ79_00485 ENOG4105CSA Coproporphyrinogen iii oxidase ASZ79_00486 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) ASZ79_00488 ENOG4105VZ9 UPF0235 protein ASZ79_00489 ENOG4108VIA integral membrane protein ASZ79_00490 ENOG4105II7 pyrroline-5-carboxylate reductase ASZ79_00491 ENOG4105DFA alanine racemase domain protein ASZ79_00492 ENOG4105CZX twitching motility protein ASZ79_00493 ENOG4105CZX twitching motility protein ASZ79_00495 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) ASZ79_00496 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) ASZ79_00497 ENOG4108UJU UPF0301 protein ASZ79_00498 ENOG4105D7Z glutathione synthase ASZ79_00499 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) ASZ79_00500 ENOG4105RWS endonuclease I ASZ79_00501 ENOG4105GPY SprT protein ASZ79_00502 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP ASZ79_00504 ENOG4105CV1 Transketolase (EC 2.2.1.1) ASZ79_00505 ENOG4108R4R Iron-regulated virulence regulatory protein ASZ79_00506 ENOG4105D05 Receptor ASZ79_00507 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase ASZ79_00508 ENOG4105BZA Phosphoglycerate kinase ASZ79_00509 ENOG4105D2N Aldolase ASZ79_00510 ENOG4105D64 Mechanosensitive ion channel ASZ79_00511 ENOG4108ZUB Lysine exporter protein (Lyse ygga) ASZ79_00512 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) ASZ79_00513 ENOG4105MPN Membrane ASZ79_00515 ENOG4105CA9 Pyruvate kinase ASZ79_00516 ENOG410804X Transcriptional regulator ASZ79_00517 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) ASZ79_00518 ENOG4105CH5 extracellular solute-binding protein, family 7 ASZ79_00529 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) ASZ79_00536 ENOG4105DR5 peptidase ASZ79_00543 ENOG4108YGG dna repair protein ASZ79_00545 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor ASZ79_00547 ENOG4105C8Q Methyl-accepting chemotaxis ASZ79_00548 ENOG4105D58 Diguanylate phosphodiesterase ASZ79_00549 ENOG4105DFP Integrase ASZ79_00551 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ASZ79_00552 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) ASZ79_00553 ENOG4105KTH gatB Yqey ASZ79_00554 ENOG4105VCC 30S ribosomal protein S21 ASZ79_00556 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) ASZ79_00558 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) ASZ79_00559 ENOG4107ZVW dihydroneopterin aldolase ASZ79_00560 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase ASZ79_00561 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) ASZ79_00563 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) ASZ79_00564 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) ASZ79_00565 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) ASZ79_00566 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) ASZ79_00567 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) ASZ79_00568 ENOG4108K5P (LipO)protein ASZ79_00569 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ASZ79_00570 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) ASZ79_00571 ENOG4105C6T cysteine synthase ASZ79_00572 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein ASZ79_00573 ENOG4108I5D sulfate abc transporter ASZ79_00574 ENOG4105ECW sulfate abc transporter ASZ79_00575 ENOG4108IJ6 ABC transporter ASZ79_00577 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) ASZ79_00578 ENOG4105Y3E Modulates RecA activity (By similarity) ASZ79_00579 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) ASZ79_00581 ENOG4105CFH Aspartokinase ASZ79_00582 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) ASZ79_00592 ENOG4107QSA Oxaloacetate decarboxylase ASZ79_00593 ENOG4105D9Q decarboxylase (Beta subunit) ASZ79_00597 ENOG41061A0 Mu-like prophage Flumu protein ASZ79_00598 ENOG4108T86 baseplate J family protein ASZ79_00600 ENOG4105PZ7 Baseplate assembly protein ASZ79_00605 ENOG41062PQ Mu-like prophage FluMu protein gp41 ASZ79_00607 ENOG4105TKZ Tail Sheath ASZ79_00612 ENOG4105Y5J prophage protein ASZ79_00614 ENOG4105EFV Major head subunit ASZ79_00621 ENOG4105QIB mu-like prophage Flumu protein gp29 ASZ79_00622 ENOG4105CF2 Mu-like prophage FluMu protein GP28 ASZ79_00624 ENOG4108Z6H mu-like prophage Flumu protein gp27 ASZ79_00635 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving ASZ79_00636 ENOG41065S5 ASZ79_00647 ENOG4108WTW DNA transposition protein ASZ79_00648 ENOG4106YXT transposase ASZ79_00649 ENOG4105R8V Transcriptional regulator ASZ79_00652 ENOG4105W39 Membrane ASZ79_00654 ENOG4105D9M gamma-glutamylcysteine synthetase ASZ79_00655 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) ASZ79_00656 ENOG4108JU6 CBS domain protein ASZ79_00657 ENOG4106KVJ cytochrome C assembly protein ASZ79_00658 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ASZ79_00659 ENOG4105K5M 30s ribosomal protein S16 ASZ79_00660 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) ASZ79_00661 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) ASZ79_00662 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) ASZ79_00663 ENOG4105C0H protease ASZ79_00664 ENOG4105C0H protease ASZ79_00666 ENOG4105D6Z AFG1 family ATPase ASZ79_00667 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) ASZ79_00668 ENOG4108UJD 30S ribosomal protein S9 ASZ79_00669 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) ASZ79_00670 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) ASZ79_00671 ENOG4105EIX cytochrome c1 ASZ79_00672 ENOG4107MKT Stringent starvation protein a ASZ79_00673 ENOG4105KB2 stringent starvation protein b ASZ79_00674 ENOG4105W4M Transport-associated protein ASZ79_00675 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) ASZ79_00676 ENOG41082RQ UPF0102 protein ASZ79_00677 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) ASZ79_00678 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) ASZ79_00679 ENOG410630P Transcriptional regulator ASZ79_00680 ENOG4108UGV hypoxanthine phosphoribosyltransferase ASZ79_00681 ENOG41077A9 carbonic anhydrase ASZ79_00682 ENOG4105CHH sulfate transporter ASZ79_00683 ENOG4105DA5 (ABC) transporter ASZ79_00684 ENOG4105E3A (ABC) transporter ASZ79_00685 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) ASZ79_00686 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) ASZ79_00687 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase ASZ79_00688 ENOG4105DJ0 Poly(A) Polymerase ASZ79_00689 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) ASZ79_00690 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters ASZ79_00691 ENOG4105PW4 Sugar fermentation stimulation protein homolog ASZ79_00693 ENOG4105CQ7 ATP-dependent helicase ASZ79_00694 ENOG4105BZ4 penicillin-binding protein ASZ79_00695 ENOG4105D78 K07001 NTE family protein ASZ79_00696 ENOG4107QIJ Aconitate hydratase 2 ASZ79_00697 ENOG4105XTV UPF0231 protein ASZ79_00698 ENOG4108YZA Nitrogen regulatory protein pii ASZ79_00702 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ASZ79_00704 ENOG4105E2V Glycosyltransferase 36 ASZ79_00705 ENOG4105E2D ec 3.2.1.52 ASZ79_00706 ENOG4105RD7 BadF BadG BcrA BcrD ASZ79_00708 ENOG4108JQ7 (ABC) transporter ASZ79_00709 ENOG4105C3U ABC transporter ASZ79_00710 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ASZ79_00712 ENOG4107QRA Extracellular solute-binding protein, family 5 ASZ79_00713 ENOG4105BZU Histidine kinase ASZ79_00714 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) ASZ79_00715 ENOG4105IPI Membrane ASZ79_00717 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase ASZ79_00719 ENOG4108YX9 iron--sulfur cluster insertion protein erpA ASZ79_00722 ENOG4105DR5 peptidase ASZ79_00723 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) ASZ79_00724 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase ASZ79_00725 ENOG4105FCK Membrane ASZ79_00726 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) ASZ79_00727 ENOG4105HBR Rna-binding protein ASZ79_00728 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) ASZ79_00729 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) ASZ79_00730 ENOG4105EEI dihydropteroate synthase ASZ79_00731 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) ASZ79_00735 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) ASZ79_00736 ENOG4105CHV Transcription elongation factor NusA ASZ79_00737 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) ASZ79_00738 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) ASZ79_00739 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) ASZ79_00740 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) ASZ79_00741 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) ASZ79_00742 ENOG4105RT1 May be involved in cell division (By similarity) ASZ79_00745 ENOG4106RZ4 Peptidase U32 ASZ79_00746 ENOG4105CFP Peptidase U32 ASZ79_00747 ENOG4105BZU Histidine kinase ASZ79_00749 ENOG4105XPQ lipid carrier protein ASZ79_00750 ENOG4108YYD acetyltransferase ASZ79_00753 ENOG4105BZU Histidine kinase ASZ79_00754 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) ASZ79_00755 ENOG4105C1J atp-dependent rna helicase ASZ79_00756 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) ASZ79_00757 ENOG4105CWM branched-chain amino acid transport system II carrier protein ASZ79_00758 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) ASZ79_00759 ENOG4105CRK lysyL-tRNA synthetase ASZ79_00761 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASZ79_00765 ENOG4105CPC Aldo Keto reductase ASZ79_00766 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) ASZ79_00769 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) ASZ79_00770 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase ASZ79_00771 ENOG4105HF0 Membrane ASZ79_00772 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) ASZ79_00773 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) ASZ79_00775 ENOG41063Z6 transcriptional regulator, lysR family ASZ79_00776 ENOG41080HT Transcriptional regulator, arsr family ASZ79_00777 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) ASZ79_00778 ENOG4105CJR Integral membrane protein (MviN ASZ79_00779 ENOG4105DTN riboflavin biosynthesis protein ribF ASZ79_00780 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) ASZ79_00781 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) ASZ79_00782 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase ASZ79_00783 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) ASZ79_00787 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate ASZ79_00788 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) ASZ79_00789 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) ASZ79_00790 ENOG4108NEV two component transcriptional regulator, LytTR family ASZ79_00791 ENOG4108HRK Histidine kinase ASZ79_00792 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) ASZ79_00795 ENOG4105C5H ABC transporter ASZ79_00796 ENOG4107SC1 transglycosylase ASZ79_00797 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) ASZ79_00798 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) ASZ79_00799 ENOG4108K0B C-di-gmp phosphodiesterase ASZ79_00800 ENOG4107XW0 Spermidine putrescine ABC transporter periplasmic spermidine putrescine-binding protein ASZ79_00802 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA ASZ79_00804 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane ASZ79_00805 ENOG4105C34 Pseudouridine synthase ASZ79_00806 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase ASZ79_00807 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ASZ79_00815 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding ASZ79_00816 ENOG4105CFP Peptidase U32 ASZ79_00817 ENOG4105DH7 May be involved in recombination (By similarity) ASZ79_00818 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ASZ79_00819 ENOG4105BZU Histidine kinase ASZ79_00821 ENOG4105C9X ppx gppa phosphatase ASZ79_00822 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) ASZ79_00823 ENOG4105C8U phosphate abc transporter ASZ79_00824 ENOG4105E2Z phosphate ABC transporter (Permease ASZ79_00825 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) ASZ79_00827 ENOG4105CSR polyphosphate kinase 2 ASZ79_00828 ENOG4106N3A copper homeostasis protein cutc ASZ79_00829 ENOG4105D3R alkyl hydroperoxide reductase ASZ79_00830 ENOG4105C5Q Transcriptional regulator ASZ79_00831 ENOG4107QP3 malate synthase g ASZ79_00832 ENOG4108I9X Isocitrate lyase ASZ79_00833 ENOG4105W87 Cbs domain ASZ79_00834 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) ASZ79_00835 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) ASZ79_00836 ENOG4105VIE preprotein translocase, subunit YajC ASZ79_00837 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ASZ79_00838 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ASZ79_00839 ENOG4105ECY inositol monophosphatase ASZ79_00840 ENOG4105CVS RNA methyltransferase TrmH family, group 1 ASZ79_00841 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family ASZ79_00842 ENOG4105C3J Cysteine desulfurase ASZ79_00843 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins ASZ79_00844 ENOG4108Z4V iron-sulfur cluster assembly ASZ79_00845 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) ASZ79_00846 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB ASZ79_00847 ENOG4108ZIT Ferredoxin, 2FE-2S ASZ79_00848 ENOG4105WVQ Fe-S assembly protein IscX ASZ79_00849 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) ASZ79_00850 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) ASZ79_00851 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs ASZ79_00853 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) ASZ79_00854 ENOG4105CUT histidyl-tRNA synthetase ASZ79_00855 ENOG4105N21 Membrane ASZ79_00856 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) ASZ79_00857 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) ASZ79_00860 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) ASZ79_00861 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) ASZ79_00862 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) ASZ79_00864 ENOG4106HK8 GPR1 FUN34 yaaH family protein ASZ79_00865 ENOG4105WQI isochorismatase ASZ79_00866 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase ASZ79_00867 ENOG4105E4F Isochorismate synthase ASZ79_00868 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase ASZ79_00870 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein ASZ79_00871 ENOG4105DQ5 transport system permease protein ASZ79_00872 ENOG4105TVJ transport system, permease ASZ79_00873 ENOG4105E0A ABC, transporter ASZ79_00875 ENOG41064T2 transcriptional regulator, lysR family ASZ79_00876 ENOG4105EUZ Beta-lactamase domain protein ASZ79_00877 ENOG4105BZG amino acid carrier protein ASZ79_00878 ENOG4105MWK D-amino acid dehydrogenase, small subunit ASZ79_00882 ENOG4106YYS transcriptional regulatory protein ASZ79_00883 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism ASZ79_00884 ENOG4105D9Q decarboxylase (Beta subunit) ASZ79_00885 ENOG4107QSA Oxaloacetate decarboxylase ASZ79_00888 ENOG4105DUA (citrate (pro-3S)-lyase ligase ASZ79_00889 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) ASZ79_00890 ENOG4105CI0 Citrate lyase ASZ79_00891 ENOG4105CHY citrate lyase, alpha ASZ79_00892 ENOG4105YGP holo-ACP synthase CitX ASZ79_00893 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase ASZ79_00896 ENOG4108Z4U Ferredoxin ASZ79_00897 ENOG4105DZ0 fad dependent oxidoreductase ASZ79_00907 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) ASZ79_00908 ENOG4108Z1B Cyclase dehydrase ASZ79_00909 ENOG4105VDB UPF0125 protein ASZ79_00910 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) ASZ79_00911 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) ASZ79_00912 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) ASZ79_00913 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ ASZ79_00915 ENOG4105CFG Acts as a chaperone (By similarity) ASZ79_00916 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) ASZ79_00922 ENOG4105CFC Transporter ASZ79_00923 ENOG4108Z6B deaminase ASZ79_00925 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) ASZ79_00928 ENOG4107QIK phosphoribosylformylglycinamidine synthase ASZ79_00932 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) ASZ79_00933 ENOG4108R96 Methyltransferase, YaeB family ASZ79_00934 ENOG4105NRA 50s ribosomal protein l31 type b ASZ79_00936 ENOG4105CFC Transporter ASZ79_00937 ENOG4108UPT UPF0178 protein ASZ79_00939 ENOG4108428 Inherit from COG: -acetyltransferase ASZ79_00942 ENOG4105WP7 tRNA pseudouridine synthase C ASZ79_00943 ENOG4105DR9 pseudouridine synthase ASZ79_00944 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) ASZ79_00945 ENOG4105CTB Polyprenyl synthetase ASZ79_00947 ENOG4105E14 MotA TolQ exbB proton channel ASZ79_00949 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) ASZ79_00950 ENOG4105ETT transcriptional Regulator, LysR family ASZ79_00951 ENOG4105M08 Membrane ASZ79_00952 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease ASZ79_00953 ENOG4105EWT decarboxylase family ASZ79_00954 ENOG4105BZU Histidine kinase ASZ79_00956 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) ASZ79_00957 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) ASZ79_00958 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein ASZ79_00959 ENOG4105D01 (LipO)protein ASZ79_00960 ENOG4108UMI ABC transporter, permease ASZ79_00961 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) ASZ79_00962 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase ASZ79_00963 ENOG4105D4X repressor ASZ79_00964 ENOG4105C5Y PTS System ASZ79_00965 ENOG4105CG3 alpha amylase, catalytic region ASZ79_00971 ENOG4105BZS acriflavin resistance protein ASZ79_00972 ENOG4107ZF2 Phosphatase ASZ79_00973 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase ASZ79_00975 ENOG4108UW5 maltose o-acetyltransferase ASZ79_00979 ENOG4105D7W serine acetyltransferase ASZ79_00981 ENOG4105Q84 sucrose synthase ASZ79_00983 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family ASZ79_00986 ENOG4108MA4 Peptidase M66 ASZ79_00989 ENOG4105D3Q Sugar transferase ASZ79_00991 ENOG4105DAY polysaccharide export protein ASZ79_00992 ENOG4105D75 Capsular exopolysaccharide family ASZ79_00997 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) ASZ79_00999 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) ASZ79_01000 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) ASZ79_01001 ENOG4108Z43 UPF0250 protein ASZ79_01002 ENOG4105DZ1 carboxypeptidase ASZ79_01003 ENOG4105K6T rare lipoprotein A ASZ79_01004 ENOG4105CNI cell division protein FtsW ASZ79_01005 ENOG4105CJN penicillin-binding protein ASZ79_01006 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) ASZ79_01007 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) ASZ79_01008 ENOG4105DJF DNA polymerase III, delta' subunit ASZ79_01009 ENOG4108U2H Rare lipoprotein B ASZ79_01010 ENOG4105C8T Leucyl-tRNA synthetase ASZ79_01011 ENOG4107PAI alpha helical protein ASZ79_01012 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) ASZ79_01013 ENOG4108JU5 Magnesium and cobalt efflux protein ASZ79_01014 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) ASZ79_01015 ENOG4105C9A Phoh family ASZ79_01016 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) ASZ79_01017 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family ASZ79_01018 ENOG4105C5Y PTS System ASZ79_01020 ENOG4105KZ7 phosphocarrier protein hpr ASZ79_01021 ENOG4105C6T cysteine synthase ASZ79_01022 ENOG4105EXN Sulfate transport protein CysZ ASZ79_01023 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) ASZ79_01024 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) ASZ79_01025 ENOG41081QG Porin Gram-negative type ASZ79_01027 ENOG4108Z6Z Transcriptional regulator ASZ79_01028 ENOG4105G5H Membrane ASZ79_01029 ENOG4107QX8 SPFH domain, Band 7 family protein ASZ79_01030 ENOG4107QR8 Thioredoxin ASZ79_01032 ENOG4105E1F short-chain dehydrogenase reductase ASZ79_01033 ENOG4105ECP epimerase ASZ79_01034 ENOG4108RE9 Phosphodiesterase ASZ79_01037 ENOG4108TU9 TRANSCRIPTIONal ASZ79_01038 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) ASZ79_01039 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) ASZ79_01040 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) ASZ79_01041 ENOG4105DUX Transporter ASZ79_01043 ENOG4105MDZ Transcriptional activator rfaH ASZ79_01044 ENOG4105CAQ asparagine synthetase ASZ79_01045 ENOG4105CKD glutathione-regulated potassium-efflux system protein ASZ79_01046 ENOG4105E2R ROK family ASZ79_01047 ENOG4105CE4 GlcNAc 6-P deacetylase ASZ79_01048 ENOG4105CI1 PTS System ASZ79_01049 ENOG4105CX6 glutaminyL-tRNA synthetase ASZ79_01052 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) ASZ79_01053 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) ASZ79_01054 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase ASZ79_01055 ENOG4108S3P Sporulation domain protein ASZ79_01056 ENOG4105E96 Colicin v production protein ASZ79_01057 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase ASZ79_01058 ENOG4105D3Y Na H antiporter ASZ79_01059 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) ASZ79_01061 ENOG4105EIY sodium-type flagellar protein motY ASZ79_01062 ENOG4106WH9 Protein of unknown function (DUF2753) ASZ79_01063 ENOG4108UYE Lactoylglutathione lyase ASZ79_01064 ENOG4105CSM endonuclease III ASZ79_01065 ENOG4105DZB Electron transport complex ASZ79_01066 ENOG4108UQQ Electron transport complex ASZ79_01067 ENOG4105D6A Electron transport complex ASZ79_01069 ENOG4108R3D Electron transport complex ASZ79_01073 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) ASZ79_01074 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASZ79_01076 ENOG4105CHW UPF0052 protein ASZ79_01077 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) ASZ79_01078 ENOG4108RIR Molybdenum cofactor biosynthesis protein ASZ79_01079 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) ASZ79_01080 ENOG4105M00 molybdopterin converting factor, subunit 1 ASZ79_01081 ENOG4108ZAF Molybdopterin ASZ79_01082 ENOG4105BZU Histidine kinase ASZ79_01085 ENOG4108I5U Uridine phosphorylase ASZ79_01087 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) ASZ79_01088 ENOG4105D1F ATP-binding protein ASZ79_01089 ENOG4105DBI uridine monophosphokinase ASZ79_01090 ENOG4108GAE asmA family ASZ79_01091 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase ASZ79_01093 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation ASZ79_01094 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation ASZ79_01097 ENOG4105CHU acetyl-coa acetyltransferase ASZ79_01098 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ASZ79_01099 ENOG41069NU Nitroreductase ASZ79_01100 ENOG4105EJC lysr family transcriptional regulator ASZ79_01101 ENOG4105I93 response regulator ASZ79_01104 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) ASZ79_01105 ENOG4107QMP dna polymerase iii subunits gamma and tau ASZ79_01106 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) ASZ79_01107 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) ASZ79_01108 ENOG4105KRS Proteinase inhibitor ASZ79_01110 ENOG4105UBK short-chain dehydrogenase reductase ASZ79_01111 ENOG4105ERU peptidase ASZ79_01113 ENOG4108XM1 transcriptional regulator AsnC family ASZ79_01114 ENOG4105C29 acyl-CoA thioesterase ASZ79_01118 ENOG4105BZU Histidine kinase ASZ79_01119 ENOG41082YX Transcriptional regulator, arsr family ASZ79_01120 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase ASZ79_01126 ENOG4108V1U phospholipid-binding protein ASZ79_01130 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) ASZ79_01133 ENOG4107YTP response regulator receiver protein ASZ79_01135 ENOG4105BZU Histidine kinase ASZ79_01136 ENOG4105BZU Histidine kinase ASZ79_01137 ENOG4105BZU Histidine kinase ASZ79_01138 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASZ79_01141 ENOG4107QSI ABC, transporter ASZ79_01142 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ASZ79_01143 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ASZ79_01144 ENOG4105C3U ABC transporter ASZ79_01145 ENOG4108JQ7 (ABC) transporter ASZ79_01146 ENOG4105CHF Glutathione S-transferase ASZ79_01147 ENOG4108DNC Involved in acetate metabolism (By similarity) ASZ79_01148 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) ASZ79_01149 ENOG4105PQ6 UPF0208 membrane protein ASZ79_01150 ENOG4105VYA Uncharacterized conserved protein (DUF2132) ASZ79_01152 ENOG4105C7J ABC transporter, permease ASZ79_01153 ENOG4108JJB ABC transporter ASZ79_01154 ENOG4105BZU Histidine kinase ASZ79_01155 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) ASZ79_01156 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving ASZ79_01158 ENOG4105D1H recombination factor protein RarA ASZ79_01159 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) ASZ79_01160 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) ASZ79_01161 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) ASZ79_01162 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) ASZ79_01163 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) ASZ79_01164 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) ASZ79_01166 ENOG4105D0M Protease HtpX homolog ASZ79_01168 ENOG4107FW0 short-chain dehydrogenase reductase ASZ79_01171 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase ASZ79_01173 ENOG4105RHG ASZ79_01175 ENOG4107QTF adenylosuccinate lyase ASZ79_01176 ENOG41075W9 High frequency lysogenization protein HflD homolog ASZ79_01177 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) ASZ79_01178 ENOG4107RE1 Inosine-guanosine kinase ASZ79_01180 ENOG4107S6Z Na H antiporter ASZ79_01181 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) ASZ79_01182 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) ASZ79_01183 ENOG4105CIH Imidazole acetol-phosphate transaminase ASZ79_01184 ENOG4105ECC imidazole-glycerol-phosphate dehydratase ASZ79_01185 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) ASZ79_01186 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase ASZ79_01187 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) ASZ79_01188 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase ASZ79_01189 ENOG4108R99 pseudouridine synthase ASZ79_01191 ENOG4105VEQ Cold shock protein ASZ79_01192 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) ASZ79_01193 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ASZ79_01195 ENOG41090BQ Glutaredoxin ASZ79_01196 ENOG4108EKI Dehydrogenase ASZ79_01197 ENOG4106KNT transcriptional regulator ASZ79_01198 ENOG4105DY8 decarboxylase ASZ79_01200 ENOG4105DWU Membrane ASZ79_01205 ENOG4105CUX Signal transduction histidine kinase ASZ79_01207 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) ASZ79_01210 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) ASZ79_01211 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) ASZ79_01212 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) ASZ79_01213 ENOG41081XQ Conserved Protein ASZ79_01214 ENOG4105C9M aspartyl-trna synthetase ASZ79_01215 ENOG4107104 thymidine kinase ASZ79_01216 ENOG4105CK2 sodium dicarboxylate symporter ASZ79_01217 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) ASZ79_01218 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) ASZ79_01219 ENOG4105DK0 Indole-3-glycerol phosphate synthase ASZ79_01220 ENOG4108I0Q anthranilate phosphoribosyltransferase ASZ79_01221 ENOG4105DDQ anthranilate synthase ASZ79_01222 ENOG4105CRQ synthase (Component I) ASZ79_01224 ENOG4105DB7 PHP domain protein ASZ79_01225 ENOG4107RTD sua5 ycio yrdc ywlc family protein ASZ79_01226 ENOG4105FE9 pseudouridine synthase ASZ79_01227 ENOG4108JJ8 (ABC) transporter ASZ79_01228 ENOG4108JJ9 ABC, transporter ASZ79_01229 ENOG4105C3M thioredoxin reductase ASZ79_01231 ENOG4105C9B Cysteine desulfurase ASZ79_01232 ENOG4105BZU Histidine kinase ASZ79_01233 ENOG4107GZ4 SanA protein ASZ79_01235 ENOG4107R1I NAD-dependent malic enzyme ASZ79_01237 ENOG4105C8V SAICAR synthetase ASZ79_01241 ENOG4108ZG0 Ompa motb domain protein ASZ79_01244 ENOG4105CQB FAD linked oxidase domain protein ASZ79_01246 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap ASZ79_01248 ENOG4105C84 Histidine ammonia-lyase ASZ79_01249 ENOG4105CGP Urocanate hydratase ASZ79_01250 ENOG41088SP formiminoglutamate hydrolase ASZ79_01251 ENOG4105CI2 imidazolone-5-propionate hydrolase ASZ79_01252 ENOG4105CZE histidine utilization repressor ASZ79_01255 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) ASZ79_01257 ENOG4105BZU Histidine kinase ASZ79_01258 ENOG4105CQ2 DNA polymerase ASZ79_01259 ENOG4105WH1 Two component transcriptional regulator luxr family ASZ79_01260 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) ASZ79_01266 ENOG4105BZU Histidine kinase ASZ79_01269 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) ASZ79_01270 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) ASZ79_01271 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) ASZ79_01273 ENOG4105FQ6 thiopurine methyltransferase ASZ79_01274 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR ASZ79_01276 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) ASZ79_01277 ENOG41067MG lrgb family ASZ79_01279 ENOG4105CJB Exodeoxyribonuclease I ASZ79_01280 ENOG4108ETY sodium dicarboxylate symporter ASZ79_01281 ENOG4105E0X reductase ASZ79_01283 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) ASZ79_01284 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) ASZ79_01285 ENOG4108YZT Adenosylcobinamide kinase ASZ79_01288 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) ASZ79_01289 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) ASZ79_01292 ENOG4105C8Q Methyl-accepting chemotaxis ASZ79_01297 ENOG4107QK7 reductase ASZ79_01298 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ASZ79_01299 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ASZ79_01300 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) ASZ79_01301 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ASZ79_01302 ENOG4105C72 UPF0176 protein ASZ79_01304 ENOG4105S8Q sugar efflux transporter ASZ79_01306 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) ASZ79_01311 ENOG4105DIT ErfK YbiS YcfS YnhG family protein ASZ79_01312 ENOG4105EAQ (twin-arginine translocation) pathway signal ASZ79_01313 ENOG4105C5X domain protein ASZ79_01316 ENOG4105CH5 extracellular solute-binding protein, family 7 ASZ79_01318 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ASZ79_01321 ENOG41067TZ transcriptional regulator, MarR family ASZ79_01322 ENOG4105C94 Transporter ASZ79_01324 ENOG4105VZJ PTS System ASZ79_01326 ENOG4105VCP PTS System ASZ79_01327 ENOG4105F8D glycoside hydrolase family 4 ASZ79_01328 ENOG410901P UPF0249 protein ASZ79_01329 ENOG41060NJ transcriptional regulator ASZ79_01330 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) ASZ79_01331 ENOG4105DJ9 glucan biosynthesis protein ASZ79_01332 ENOG4105C8Q Methyl-accepting chemotaxis ASZ79_01335 ENOG4105CGF Aromatic amino acid aminotransferase ASZ79_01337 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase ASZ79_01339 ENOG4105C5S asparaginyl-tRNA synthetase ASZ79_01340 ENOG4108NVR Methyl-accepting chemotaxis ASZ79_01341 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase ASZ79_01342 ENOG4105EJQ L-serine dehydratase ASZ79_01343 ENOG4105C44 Serine transporter ASZ79_01344 ENOG4105P8F nudix hydrolase ASZ79_01345 ENOG4105CRQ synthase (Component I) ASZ79_01348 ENOG4105CM6 amino acid regulated cytosolic protein ASZ79_01350 ENOG4108JU8 Transcriptional regulator ASZ79_01351 ENOG4105D9U N-acetyltransferase ASZ79_01354 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ASZ79_01355 ENOG4108NVR Methyl-accepting chemotaxis ASZ79_01356 ENOG4105C8P )-transporter ASZ79_01357 ENOG4105BZU Histidine kinase ASZ79_01358 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASZ79_01359 ENOG4108MJ5 VirK protein ASZ79_01360 ENOG4105RW8 MltA-interacting MipA family protein ASZ79_01361 ENOG4105EB3 Histidine kinase ASZ79_01362 ENOG4107EXC regulatoR ASZ79_01368 ENOG4105C2J ABC transporter ASZ79_01369 ENOG4107SDZ Galactoside transport system permease protein mglC ASZ79_01375 ENOG41073TP transcriptional regulator ASZ79_01376 ENOG4105CR4 methylisocitrate lyase ASZ79_01377 ENOG4105BZN citrate synthase ASZ79_01378 ENOG4108I0Z Aconitate hydratase ASZ79_01379 ENOG4105C7F AcnD-accessory protein PrpF ASZ79_01380 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ASZ79_01383 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) ASZ79_01384 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase ASZ79_01385 ENOG4105F1J Homogentisate 1,2-dioxygenase ASZ79_01387 ENOG4108RXX maleylacetoacetate isomerase ASZ79_01388 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase ASZ79_01389 ENOG4105BZU Histidine kinase ASZ79_01391 ENOG4106TD9 Diguanylate cyclase ASZ79_01392 ENOG4105DR4 Methyltransferase ASZ79_01393 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 ASZ79_01394 ENOG4108Z0T Part of a sulfur-relay system (By similarity) ASZ79_01395 ENOG4108MN8 Membrane ASZ79_01396 ENOG4105CDA abc transporter atp-binding protein ASZ79_01397 ENOG4105DRP amino acid AbC transporter ASZ79_01398 ENOG4105EZ7 amino acid ABC transporter ASZ79_01399 ENOG4107QXX ABC transporter ASZ79_01401 ENOG410667J hydrolase ASZ79_01402 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) ASZ79_01403 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) ASZ79_01404 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) ASZ79_01408 ENOG4105BZU Histidine kinase ASZ79_01410 ENOG4105BZU Histidine kinase ASZ79_01411 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB ASZ79_01412 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB ASZ79_01414 ENOG4105BZU Histidine kinase ASZ79_01420 ENOG4105CQ7 ATP-dependent helicase ASZ79_01422 ENOG4105R8A Heat shock protein ASZ79_01423 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) ASZ79_01425 ENOG4105EJC lysr family transcriptional regulator ASZ79_01426 ENOG4105C0R drug resistance transporter emrb qaca subfamily ASZ79_01427 ENOG4105CVP deoxyribo-dipyrimidine photolyase ASZ79_01428 ENOG4105KPY Small multidrug resistance protein ASZ79_01429 ENOG4108NVR Methyl-accepting chemotaxis ASZ79_01430 ENOG4108VYJ response regulator receiver protein ASZ79_01432 ENOG4105CBS Chea signal transduction histidine kinase ASZ79_01433 ENOG4105CBS Chea signal transduction histidine kinase ASZ79_01434 ENOG4105BZU Histidine kinase ASZ79_01436 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) ASZ79_01437 ENOG4108V3W Chemotaxis protein, CheW ASZ79_01438 ENOG4105C8Q Methyl-accepting chemotaxis ASZ79_01439 ENOG4108N3W hemolysin secretion protein ASZ79_01440 ENOG4107SDU Methyl-accepting chemotaxis ASZ79_01441 ENOG4105C1J atp-dependent rna helicase ASZ79_01443 ENOG4105ENJ RND efflux system, outer membrane lipoprotein ASZ79_01444 ENOG4105CW7 secretion protein, HlyD family ASZ79_01445 ENOG4105C0R drug resistance transporter emrb qaca subfamily ASZ79_01446 ENOG4105C8Q Methyl-accepting chemotaxis ASZ79_01447 ENOG4105CTD carboxy-peptidase ASZ79_01448 ENOG4108WC9 type VI secretion system effector, hcp1 family ASZ79_01449 ENOG4105CS6 Rhs element vgr protein ASZ79_01454 ENOG410829K Lysine exporter protein (Lyse ygga) ASZ79_01455 ENOG4105BZG amino acid carrier protein ASZ79_01458 ENOG4107RUE extracellular solute-binding protein family 1 ASZ79_01459 ENOG4107RUE extracellular solute-binding protein family 1 ASZ79_01460 ENOG4105D38 putrescine abc transporter ASZ79_01461 ENOG4105F38 ABC transporter, permease ASZ79_01462 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ASZ79_01466 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) ASZ79_01467 ENOG4105Q9Y Universal stress protein ASZ79_01468 ENOG4105DS0 Transcriptional regulator, Crp Fnr family ASZ79_01471 ENOG4105C59 p-type ATPase ASZ79_01473 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) ASZ79_01476 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i ASZ79_01478 ENOG4105BZU Histidine kinase ASZ79_01483 ENOG4108RC6 RTX toxin ASZ79_01484 ENOG4105EUK rtx toxin RtxA ASZ79_01485 ENOG4107927 Cholera enterotoxin, A subunit ASZ79_01486 ENOG4105MQ5 zona occludens toxin ASZ79_01507 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) ASZ79_01508 ENOG4105DAN ATP-dependent protease ASZ79_01509 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) ASZ79_01511 ENOG4105C5H ABC transporter ASZ79_01513 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) ASZ79_01515 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) ASZ79_01516 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) ASZ79_01517 ENOG4105C7I Dehydrogenase ASZ79_01519 ENOG4105CD8 aminopeptidase N ASZ79_01521 ENOG4105CN1 protease ASZ79_01522 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) ASZ79_01523 ENOG4108ZGC gaf domain protein ASZ79_01524 ENOG4105BZ1 (ABC) transporter ASZ79_01525 ENOG4105H2K paraquat-inducible protein a ASZ79_01526 ENOG4105DY2 Paraquat-inducible protein b ASZ79_01527 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B ASZ79_01528 ENOG4105QNR S1 RNA binding domain protein ASZ79_01531 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) ASZ79_01533 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) ASZ79_01536 ENOG4105QAX Iron-sulfur ASZ79_01537 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ASZ79_01539 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) ASZ79_01543 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) ASZ79_01544 ENOG4105C5H ABC transporter ASZ79_01545 ENOG4105BZU Histidine kinase ASZ79_01546 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASZ79_01548 ENOG4107A5B Binding-protein-dependent transport systems, inner membrane component ASZ79_01549 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ASZ79_01550 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) ASZ79_01551 ENOG4105CVM Molybdenum cofactor synthesis domain protein ASZ79_01556 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) ASZ79_01557 ENOG4106IUH DTW domain containing protein ASZ79_01559 ENOG4105C8Q Methyl-accepting chemotaxis ASZ79_01560 ENOG4107TT5 NLP P60 protein ASZ79_01562 ENOG4105FGM Fructosamine kinase ASZ79_01564 ENOG4107QI1 Mate efflux family protein ASZ79_01568 ENOG41067XB TonB family ASZ79_01569 ENOG4109015 Biopolymer transport protein exbD tolR ASZ79_01575 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component ASZ79_01576 ENOG4108IJ9 (ABC) transporter ASZ79_01577 ENOG4105E98 transcriptional regulator DeoR family ASZ79_01578 ENOG4107VXM glycerophosphoryl diester phosphodiesterase ASZ79_01579 ENOG4105XEP YhcH YjgK YiaL family protein ASZ79_01580 ENOG4105M4H endoribonuclease L-psp ASZ79_01582 ENOG4105DDV Transcriptional regulator (LacI family ASZ79_01583 ENOG4105CS2 ec 3.2.1.21 ASZ79_01584 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) ASZ79_01587 ENOG4107QZV Type I secretion membrane fusion protein ASZ79_01589 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ASZ79_01590 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ASZ79_01591 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) ASZ79_01592 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ASZ79_01593 ENOG4105C4M (Ubiquinol oxidase) subunit I ASZ79_01595 ENOG4105C9Q fumarate hydratase class II ASZ79_01601 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) ASZ79_01602 ENOG4105DUM transcriptional regulator, lysR family ASZ79_01603 ENOG4108TWJ NADH dehydrogenase subunit 5 ASZ79_01605 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ASZ79_01607 ENOG4105CH6 catalase ASZ79_01610 ENOG4107FQX Alpha-acetolactate decarboxylase ASZ79_01611 ENOG4105C7K acetolactate synthase ASZ79_01613 ENOG4105BZU Histidine kinase ASZ79_01614 ENOG4106TD9 Diguanylate cyclase ASZ79_01615 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) ASZ79_01616 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) ASZ79_01617 ENOG4105F0Z galactose-1-phosphate uridylyltransferase ASZ79_01622 ENOG4105BZU Histidine kinase ASZ79_01625 ENOG4107R88 Chemotaxis protein (CheV) ASZ79_01627 ENOG4106YYS transcriptional regulatory protein ASZ79_01628 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism ASZ79_01630 ENOG4107V40 secretion protein, HlyD family ASZ79_01634 ENOG4105CVG Homoserine O-transsuccinylase ASZ79_01635 ENOG41090FY type IV pilus biogenesis stability protein PilW ASZ79_01638 ENOG4108VKG metal-dependent hydrolase ASZ79_01640 ENOG4105F04 LysR family Transcriptional regulator ASZ79_01644 ENOG4105DFG type I secretion outer membrane protein ASZ79_01645 ENOG4105CDV Ompa motb domain protein ASZ79_01646 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) ASZ79_01647 ENOG4105E3Q saccharopine dehydrogenase ASZ79_01649 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) ASZ79_01652 ENOG4108I0Y (ABC) transporter ASZ79_01653 ENOG4105UQX Mate efflux family protein ASZ79_01654 ENOG4105CGD Nad-dependent epimerase dehydratase ASZ79_01656 ENOG4105C2C drug resistance transporter, Bcr CflA ASZ79_01657 ENOG4105I08 Pseudouridine synthase ASZ79_01658 ENOG4105CFI type iii restriction protein res subunit ASZ79_01662 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) ASZ79_01665 ENOG4108N3W hemolysin secretion protein ASZ79_01671 ENOG4105KXC Collagenase ASZ79_01673 ENOG4105BZU Histidine kinase ASZ79_01674 ENOG4105BZU Histidine kinase ASZ79_01675 ENOG4105CJW magnesium transporter ASZ79_01678 ENOG4105C44 Serine transporter ASZ79_01680 ENOG4105CJ1 ABC, transporter ASZ79_01681 ENOG4107QWP ABC-2 type transporter ASZ79_01683 ENOG4105XZD Fe-S protein ASZ79_01685 ENOG4105VNH ABC transporter solute-binding protein ASZ79_01686 ENOG4105CXZ ABC transporter, permease ASZ79_01687 ENOG4108VGW abc transporter atp-binding protein ASZ79_01688 ENOG4108T9J Cdp-alcohol phosphatidyltransferase ASZ79_01689 ENOG4108W1A pseudouridine synthase ASZ79_01691 ENOG4105C8J )-transporter ASZ79_01692 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) ASZ79_01693 ENOG4105C28 cystathionine ASZ79_01694 ENOG4108R3E Dna-3-methyladenine glycosylase i ASZ79_01697 ENOG4105C1P efflux transporter, rnd family, mfp subunit ASZ79_01700 ENOG41087YS Phage shock protein A ASZ79_01701 ENOG4105E51 psp operon transcriptional activator ASZ79_01702 ENOG4108J59 Extracellular solute-binding protein, family 5 ASZ79_01703 ENOG4108I5W peptide transport system, permease protein ASZ79_01704 ENOG4108EU3 peptide transport system, permease ASZ79_01705 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein ASZ79_01706 ENOG4108JQ2 peptide transport system atp-binding protein ASZ79_01709 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase ASZ79_01714 ENOG4107QY8 reductase ASZ79_01717 ENOG4105TMB Formate nitrite transporter ASZ79_01719 ENOG4108535 NAD dependent epimerase/dehydratase family ASZ79_01720 ENOG4105GFG DUF218 domain ASZ79_01722 ENOG4107835 probably involved in intracellular septation (By similarity) ASZ79_01723 ENOG4105NAU thioesterase Superfamily protein ASZ79_01724 ENOG4105K9H YciI-like protein ASZ79_01726 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) ASZ79_01727 ENOG4105DZ2 Transcriptional regulator ASZ79_01731 ENOG4105BZU Histidine kinase ASZ79_01732 ENOG4105CCT upf0313 protein ASZ79_01734 ENOG4105EW9 transcriptional regulator AsnC family ASZ79_01735 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) ASZ79_01736 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) ASZ79_01737 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) ASZ79_01738 ENOG4106371 Methyltransferase ASZ79_01739 ENOG4107S90 membrAne ASZ79_01740 ENOG4106WF9 DNA-binding transcriptional regulator TorR ASZ79_01741 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) ASZ79_01742 ENOG4105ETE Transcriptional regulator (LacI family ASZ79_01743 ENOG4105HP8 regulator of competence-specific genes ASZ79_01747 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) ASZ79_01748 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) ASZ79_01750 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) ASZ79_01751 ENOG4105RKX Protein of unknown function (DUF2498) ASZ79_01752 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase ASZ79_01754 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) ASZ79_01755 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate ASZ79_01756 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) ASZ79_01758 ENOG4107QPN acyl-Coa dehydrogenase ASZ79_01759 ENOG41067SE Tetr family transcriptional regulator ASZ79_01762 ENOG4105MTM Protein of unknown function (DUF1496) ASZ79_01763 ENOG4105C26 Dehydrogenase ASZ79_01764 ENOG4108R86 Transcriptional regulator ASZ79_01769 ENOG4105F1S paraquat-inducible protein a ASZ79_01770 ENOG4105DY2 Paraquat-inducible protein b ASZ79_01775 ENOG4105DFP Integrase ASZ79_01776 ENOG4105DFP Integrase ASZ79_01777 ENOG4105C0D helicase ASZ79_01781 ENOG4105DZR Type I site-specific deoxyribonuclease ASZ79_01785 ENOG4105CVR type I restriction-modification system ASZ79_01789 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) ASZ79_01790 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) ASZ79_01791 ENOG4105QEK Transcriptional regulator ASZ79_01793 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ASZ79_01794 ENOG41069H7 transport system small permease component ASZ79_01795 ENOG4108ERU trap dicarboxylate transporter subunit DctP ASZ79_01796 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) ASZ79_01797 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) ASZ79_01798 ENOG4105CE4 GlcNAc 6-P deacetylase ASZ79_01799 ENOG4108478 ec 3.2.1.18 ASZ79_01801 ENOG4108YGG dna repair protein ASZ79_01806 ENOG4108NYK Tape measure protein ASZ79_01828 ENOG4105CVP deoxyribo-dipyrimidine photolyase ASZ79_01830 ENOG4105VYA Uncharacterized conserved protein (DUF2132) ASZ79_01831 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family ASZ79_01832 ENOG4105C26 Dehydrogenase ASZ79_01834 ENOG4105DM4 PTS System ASZ79_01835 ENOG4105DM4 PTS System ASZ79_01836 ENOG4108YRF PTS System ASZ79_01838 ENOG4106R3P AraC family transcriptional regulator ASZ79_01839 ENOG4105DM4 PTS System ASZ79_01840 ENOG4105EIP mannose-6-phosphate isomerase ASZ79_01841 ENOG4108RNS Exports L-alanine (By similarity) ASZ79_01842 ENOG4105BZU Histidine kinase ASZ79_01844 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) ASZ79_01846 ENOG4105KCK Peptidoglycan-associated lipoprotein ASZ79_01847 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) ASZ79_01849 ENOG4105M8F Biopolymer transport protein exbD tolR ASZ79_01850 ENOG4105E02 MotA TolQ exbB proton channel ASZ79_01851 ENOG4107YD3 Thioesterase ASZ79_01852 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ASZ79_01853 ENOG4105C4M (Ubiquinol oxidase) subunit I ASZ79_01854 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) ASZ79_01855 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) ASZ79_01856 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) ASZ79_01857 ENOG4105C8N cysteinyl-tRNA synthetase ASZ79_01858 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) ASZ79_01859 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) ASZ79_01860 ENOG4105D58 Diguanylate phosphodiesterase ASZ79_01863 ENOG4105ZU8 porin-like protein H ASZ79_01864 ENOG4105DVT helicase ASZ79_01865 ENOG4105EJ9 Membrane ASZ79_01866 ENOG4108URS primosomal replication protein n'' ASZ79_01867 ENOG4106428 Protein of unknown function (DUF2496) ASZ79_01868 ENOG4105C8Q Methyl-accepting chemotaxis ASZ79_01869 ENOG4105CGK Exodeoxyribonuclease III ASZ79_01870 ENOG4106YG3 ABC transporter ASZ79_01871 ENOG4105DSP amino acid AbC transporter ASZ79_01872 ENOG4105E89 ABC transporter ASZ79_01873 ENOG4108JEH abc transporter atp-binding protein ASZ79_01875 ENOG4105C6N Formate acetyltransferase ASZ79_01877 ENOG4108N3W hemolysin secretion protein ASZ79_01878 ENOG4105F1A Pyruvate formate-lyase ASZ79_01880 ENOG4105XWI UPF0304 protein ASZ79_01881 ENOG4105CYN Serine protein kinase ASZ79_01882 ENOG4106AKX UPF0229 protein ASZ79_01883 ENOG4105ED1 spovr family ASZ79_01884 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) ASZ79_01886 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) ASZ79_01887 ENOG4105BZ1 (ABC) transporter ASZ79_01888 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 ASZ79_01890 ENOG4105D60 lipoprotein releasing system transmembrane protein ASZ79_01891 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) ASZ79_01892 ENOG4105D60 lipoprotein releasing system transmembrane protein ASZ79_01894 ENOG4108JA2 transcriptioN-repair coupling factor ASZ79_01896 ENOG4106M3D hemolysin ASZ79_01898 ENOG4105CEP NADH dehydrogenase ASZ79_01904 ENOG4105K59 histidine triad (HIT) protein ASZ79_01905 ENOG4108NVR Methyl-accepting chemotaxis ASZ79_01907 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) ASZ79_01908 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) ASZ79_01909 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) ASZ79_01910 ENOG4105CNU cell division protein FtsK ASZ79_01911 ENOG4105EW9 transcriptional regulator AsnC family ASZ79_01912 ENOG4105DCF alanine dehydrogenase ASZ79_01914 ENOG4107R11 Transcriptional regulator ASZ79_01917 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase ASZ79_01918 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) ASZ79_01919 ENOG4105CFV Tetratricopeptide repeat protein ASZ79_01920 ENOG4105Q4A inner membrane protein yciS ASZ79_01921 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) ASZ79_01922 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) ASZ79_01923 ENOG4105CAT Cytidine monophosphate kinase ASZ79_01924 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein ASZ79_01925 ENOG4105EIN peptidylprolyl cis-trans isomerase ASZ79_01926 ENOG4105K70 DNA-binding protein ASZ79_01927 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) ASZ79_01928 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) ASZ79_01929 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) ASZ79_01930 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation ASZ79_01933 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASZ79_01934 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ASZ79_01935 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ ASZ79_01936 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit ASZ79_01937 ENOG4105CNG UPF0061 protein ASZ79_01940 ENOG4105BZU Histidine kinase ASZ79_01942 ENOG4108HPI phosphatidate Cytidylyltransferase ASZ79_01949 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) ASZ79_01952 ENOG4105JQN Transcriptional regulator ASZ79_01955 ENOG4107QY8 reductase ASZ79_01956 ENOG4105CUW cytochrome C-TYPE protein ASZ79_01957 ENOG410662T chitinase ASZ79_01958 ENOG4105D9N nucleoside ASZ79_01959 ENOG4105JQN Transcriptional regulator ASZ79_01960 ENOG4105CVE Lytic murein transglycosylase ASZ79_01961 ENOG4105VNG YcgL domain-containing protein ASZ79_01962 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) ASZ79_01963 ENOG4107QMS site-determining protein ASZ79_01964 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) ASZ79_01970 ENOG4107S74 Lysophospholipid transporter LplT ASZ79_01972 ENOG4108N3W hemolysin secretion protein ASZ79_01973 ENOG4108JCI Transcriptional regulator ASZ79_01974 ENOG4105DKK Benzoate ASZ79_01975 ENOG4105CEY Amp-dependent synthetase and ligase ASZ79_01976 ENOG4105DNI Converts SHCHC to OSB (By similarity) ASZ79_01977 ENOG4108IPT Naphthoate synthase ASZ79_01978 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) ASZ79_01979 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) ASZ79_01980 ENOG4105E4F Isochorismate synthase ASZ79_01981 ENOG4105CHM Aminotransferase ASZ79_01982 ENOG4105DK2 UPF0207 protein ASZ79_01983 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein ASZ79_01987 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) ASZ79_01988 ENOG4105CEY Amp-dependent synthetase and ligase ASZ79_01989 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) ASZ79_01992 ENOG41072GX Peptidase M22 Glycoprotease ASZ79_01993 ENOG4105DVT helicase ASZ79_01995 ENOG4105CIY formyltetrahydrofolate deformylase ASZ79_01996 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ASZ79_01997 ENOG4105D07 Signal peptide peptidase, SppA ASZ79_01998 ENOG4105HDK L-asparaginase ASZ79_01999 ENOG4105VUT cytoplasmic protein ASZ79_02001 ENOG4105E0X reductase ASZ79_02002 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase ASZ79_02003 ENOG4105DSB aldose 1-epimerase ASZ79_02005 ENOG4105DHI Methyltransferase ASZ79_02008 ENOG4107R88 Chemotaxis protein (CheV) ASZ79_02009 ENOG4105DAG ROK family ASZ79_02010 ENOG4105CA9 Pyruvate kinase ASZ79_02011 ENOG4108NRW Phospholipase, patatin family ASZ79_02014 ENOG4105C8J )-transporter ASZ79_02015 ENOG4105CI1 PTS System ASZ79_02016 ENOG4105F8V Hydrolase, tatD family ASZ79_02017 ENOG4107QRG dna polymerase iii ASZ79_02018 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) ASZ79_02019 ENOG4105HHA aminodeoxychorismate lyase ASZ79_02020 ENOG4105YAZ 4-amino-4-deoxychorismate lyase ASZ79_02021 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) ASZ79_02022 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) ASZ79_02023 ENOG4105CHR reductase ASZ79_02024 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase ASZ79_02025 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) ASZ79_02026 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) ASZ79_02027 ENOG4105VGS 50s ribosomal protein l32 ASZ79_02028 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein ASZ79_02029 ENOG4108UHJ MAF-like protein ASZ79_02030 ENOG4105EI2 Pseudouridine synthase ASZ79_02031 ENOG4105C03 ribonuclease ASZ79_02032 ENOG4105CHH sulfate transporter ASZ79_02034 ENOG4108EKI Dehydrogenase ASZ79_02035 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein ASZ79_02036 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) ASZ79_02037 ENOG4105DFD Na H antiporter ASZ79_02039 ENOG4106V8H Nucleoid-associated protein ASZ79_02041 ENOG4105E68 Sulfatase ASZ79_02044 ENOG4105DGU Histone deacetylase ASZ79_02045 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) ASZ79_02046 ENOG4105M2J Glutaredoxin ASZ79_02047 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ASZ79_02051 ENOG410903C (LipO)protein ASZ79_02053 ENOG4105KWW Biogenesis protein ASZ79_02054 ENOG4107QX9 Thiol disulfide interChange protein ASZ79_02055 ENOG4105DA4 cytochrome c-type biogenesis protein ASZ79_02056 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) ASZ79_02057 ENOG41067VX Heme exporter protein ASZ79_02058 ENOG41060IM Heme exporter protein ASZ79_02059 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) ASZ79_02060 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) ASZ79_02062 ENOG4108V3W Chemotaxis protein, CheW ASZ79_02064 ENOG4107QJE Chromosome Partitioning Protein ASZ79_02065 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) ASZ79_02066 ENOG4105CBS Chea signal transduction histidine kinase ASZ79_02067 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) ASZ79_02068 ENOG4108VYJ response regulator receiver protein ASZ79_02069 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ASZ79_02070 ENOG4107R21 site-determining protein ASZ79_02071 ENOG4105FZW flagellar biosynthesis regulator FlhF ASZ79_02072 ENOG4105D7B Flagellar biosynthesis protein flha ASZ79_02073 ENOG4108BY2 phosphohistidine phosphatase ASZ79_02074 ENOG4108JQM Insulinase (Peptidase family M16) ASZ79_02076 ENOG4105C75 arginyL-tRNA synthetase ASZ79_02080 ENOG4105XFK Ferrous iron transport protein A ASZ79_02081 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) ASZ79_02082 ENOG4105NXV High-affinity zinc uptake system protein ASZ79_02083 ENOG4105FDK ABC transporter ASZ79_02084 ENOG4105FAV ABC, transporter ASZ79_02085 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha ASZ79_02086 ENOG4105CMV Succinyl-CoA synthetase subunit beta ASZ79_02087 ENOG4105C7S Dehydrogenase ASZ79_02088 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 ASZ79_02089 ENOG4105E33 succinate dehydrogenase ASZ79_02090 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) ASZ79_02091 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein ASZ79_02092 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit ASZ79_02093 ENOG4105BZN citrate synthase ASZ79_02094 ENOG4107QNR UPF0135 protein ASZ79_02096 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 ASZ79_02097 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) ASZ79_02098 ENOG4105EV9 Alpha Beta Hydrolase ASZ79_02100 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) ASZ79_02101 ENOG41067MG lrgb family ASZ79_02102 ENOG4105VAW lrga family ASZ79_02103 ENOG4105CMU LysR family (Transcriptional regulator ASZ79_02105 ENOG41090R7 Ferric uptake ASZ79_02106 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) ASZ79_02107 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) ASZ79_02108 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) ASZ79_02109 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) ASZ79_02110 ENOG4105Q8W reductase ASZ79_02111 ENOG4105MH2 YfcL protein ASZ79_02112 ENOG4108BPE -transporting atpase ASZ79_02113 ENOG4105EN6 Membrane ASZ79_02114 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase ASZ79_02115 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) ASZ79_02117 ENOG4105D00 flagellar biosynthetic protein flhB ASZ79_02118 ENOG4105D19 Role in flagellar biosynthesis (By similarity) ASZ79_02119 ENOG4105VS8 Flagellar biosynthetic protein fliq ASZ79_02120 ENOG4105CN7 Flagellar biosynthetic protein FliP ASZ79_02121 ENOG4105VTB flagellar biosynthesis protein fliO ASZ79_02122 ENOG4105DD5 Flagellar motor switch protein ASZ79_02123 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) ASZ79_02124 ENOG4105X6C Flagellar basal body-associated protein FliL ASZ79_02128 ENOG4108JIR Flagellum-specific ATP synthase ASZ79_02129 ENOG4105W2B Flagellar assembly protein ASZ79_02130 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) ASZ79_02131 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) ASZ79_02132 ENOG4105VQ0 flagellar hook-basal body complex protein fliE ASZ79_02133 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASZ79_02134 ENOG4105BZU Histidine kinase ASZ79_02135 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASZ79_02136 ENOG4108JUA Transcriptional regulator ASZ79_02137 ENOG4105MQ3 flagellar protein FliS ASZ79_02139 ENOG4107W9T flagellar hook-associated ASZ79_02140 ENOG41063QE flagellar protein FlaG ASZ79_02141 ENOG4105I03 Flagellin ASZ79_02142 ENOG4105I03 Flagellin ASZ79_02143 ENOG4105I03 Flagellin ASZ79_02144 ENOG4105EZR dyp-type peroxidase family protein ASZ79_02145 ENOG4105QZU Inner membrane protein YfeZ ASZ79_02148 ENOG4105KUZ arsenate reductase ASZ79_02149 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) ASZ79_02152 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) ASZ79_02153 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ASZ79_02155 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen ASZ79_02156 ENOG4105C8Q Methyl-accepting chemotaxis ASZ79_02159 ENOG4105ERG peptidase m48, ste24p ASZ79_02160 ENOG4105K89 arsenate reductase ASZ79_02161 ENOG4105CS1 NAD(P)H quinone oxidoreductase ASZ79_02164 ENOG4105C2W permease ASZ79_02165 ENOG4108Z66 YbaK ebsC protein ASZ79_02167 ENOG4105CGH 5'-nucleotidase ASZ79_02168 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase ASZ79_02169 ENOG41063JG Transcriptional regulator ASZ79_02170 ENOG4108YY7 Invasion gene expression up-regulator SirB ASZ79_02171 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) ASZ79_02172 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) ASZ79_02173 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) ASZ79_02174 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) ASZ79_02175 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) ASZ79_02176 ENOG4105C5T Phosphoribosyl pyrophosphate synthase ASZ79_02177 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) ASZ79_02178 ENOG4105C3G gtp-binding protein ASZ79_02196 ENOG4105I03 Flagellin ASZ79_02197 ENOG4105I03 Flagellin ASZ79_02201 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj ASZ79_02202 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) ASZ79_02203 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) ASZ79_02204 ENOG4105CGA flagellar basal-body rod protein FlgG ASZ79_02205 ENOG4108KPB Flagellar basal-body rod protein FlgF ASZ79_02206 ENOG4105BZE flagellar hook protein, FlgE ASZ79_02207 ENOG4105W00 Flagellar hook capping protein ASZ79_02208 ENOG4108ZC9 flagellar basal-body rod protein flgc ASZ79_02209 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) ASZ79_02210 ENOG4105BZU Histidine kinase ASZ79_02211 ENOG4107R88 Chemotaxis protein (CheV) ASZ79_02218 ENOG4105C0W non-ribosomal peptide synthetase ASZ79_02219 ENOG4105Q26 Siderophore-interacting protein ASZ79_02220 ENOG4107RBR Receptor ASZ79_02222 ENOG4105UYK outer membrane protein a ASZ79_02223 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) ASZ79_02224 ENOG4105C59 p-type ATPase ASZ79_02226 ENOG4105E2D ec 3.2.1.52 ASZ79_02229 ENOG4105MBR gumn family ASZ79_02232 ENOG4108DG9 Smr protein MutS2 ASZ79_02233 ENOG4105FE9 pseudouridine synthase ASZ79_02234 ENOG4105BZU Histidine kinase ASZ79_02235 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) ASZ79_02236 ENOG4105CXB phosphoribosylaminoimidazole synthetase ASZ79_02237 ENOG4108V3E phosphoribosylglycinamide formyltransferase ASZ79_02238 ENOG4105E7A Glutamine amidotransferase ASZ79_02239 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) ASZ79_02240 ENOG4107QPN acyl-Coa dehydrogenase ASZ79_02242 ENOG4108JDX DNA polymerase iii, epsilon subunit ASZ79_02243 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) ASZ79_02244 ENOG4105D1A Methyltransferase ASZ79_02245 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) ASZ79_02246 ENOG4105E9H Lytic Murein transglycosylase ASZ79_02248 ENOG4108YZA Nitrogen regulatory protein pii ASZ79_02249 ENOG4105PY6 Phenolic acid decarboxylase ASZ79_02250 ENOG4105N7H Cytochrome ASZ79_02251 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) ASZ79_02252 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) ASZ79_02253 ENOG4105C0B DNA polymerase III (alpha subunit) ASZ79_02254 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) ASZ79_02255 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) ASZ79_02256 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) ASZ79_02257 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) ASZ79_02258 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) ASZ79_02259 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) ASZ79_02261 ENOG4105DZP Membrane-associated zinc metalloprotease ASZ79_02262 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) ASZ79_02263 ENOG4105KNE Phosphatidate cytidylyltransferase ASZ79_02264 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) ASZ79_02265 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) ASZ79_02266 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) ASZ79_02267 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) ASZ79_02268 ENOG4105CE9 30S ribosomal protein S2 ASZ79_02269 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) ASZ79_02270 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) ASZ79_02271 ENOG4108T8E UPF0325 protein ASZ79_02272 ENOG4108ZAI phosphatidylglycerophosphatase a ASZ79_02273 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) ASZ79_02274 ENOG4107YIM Involved in the transcription termination process (By similarity) ASZ79_02275 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) ASZ79_02278 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) ASZ79_02279 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) ASZ79_02280 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) ASZ79_02281 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) ASZ79_02282 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) ASZ79_02284 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) ASZ79_02285 ENOG4105C7N Xanthine uracil vitamin C permease ASZ79_02286 ENOG4105CIN aminoacyl-histidine dipeptidase ASZ79_02287 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) ASZ79_02288 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) ASZ79_02290 ENOG4105C8J )-transporter ASZ79_02291 ENOG4105BZU Histidine kinase ASZ79_02293 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) ASZ79_02295 ENOG4105CJ2 (LipO)protein ASZ79_02296 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) ASZ79_02297 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ASZ79_02298 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ASZ79_02299 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ASZ79_02300 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ASZ79_02301 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ASZ79_02302 ENOG4105M85 Bola protein ASZ79_02303 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) ASZ79_02305 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) ASZ79_02306 ENOG4105EYM Major Facilitator superfamily ASZ79_02308 ENOG4105K6V RNA polymerase ASZ79_02310 ENOG4105DRB nucleoside-specific channel-forming protein ASZ79_02311 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) ASZ79_02312 ENOG4107S0N DJ-1 family ASZ79_02313 ENOG4105C9B Cysteine desulfurase ASZ79_02314 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) ASZ79_02315 ENOG4105CUZ uba thif-type nad fad binding protein ASZ79_02316 ENOG4105CA3 membrane-bound lytic murein transglycosylase ASZ79_02318 ENOG4107QZM n-acetylglutamate synthase ASZ79_02320 ENOG4107QYX exodeoxyribonuclease v alpha ASZ79_02321 ENOG4107QKA exodeoxyribonuclease V beta ASZ79_02322 ENOG4105DSY exodeoxyribonuclease V, gamma ASZ79_02325 ENOG4105X2V dna damage-inducible protein ASZ79_02326 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) ASZ79_02328 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) ASZ79_02329 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) ASZ79_02332 ENOG4108Y51 tRNA-binding protein ASZ79_02333 ENOG41060NJ transcriptional regulator ASZ79_02334 ENOG4105CNT hydrolase family 2 ASZ79_02336 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase ASZ79_02337 ENOG4108IQE Amp-dependent synthetase and ligase ASZ79_02338 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) ASZ79_02339 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) ASZ79_02341 ENOG4105EAC phosphoserine phosphatase ASZ79_02343 ENOG4105D3A purine nucleoside phosphorylase DeoD-type ASZ79_02344 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) ASZ79_02345 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) ASZ79_02346 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) ASZ79_02348 ENOG4105D9N nucleoside ASZ79_02349 ENOG4105EYA deoxyribonuclease ASZ79_02352 ENOG4105BZG amino acid carrier protein ASZ79_02355 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) ASZ79_02356 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) ASZ79_02357 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) ASZ79_02358 ENOG4105D98 threonine synthase ASZ79_02359 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) ASZ79_02362 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) ASZ79_02364 ENOG41065U4 response regulator ASZ79_02365 ENOG4105BZU Histidine kinase ASZ79_02367 ENOG4105N5T Radical SAM Protein ASZ79_02370 ENOG4105CBC glutamate synthase ASZ79_02371 ENOG4105BZ8 glutamate synthase ASZ79_02373 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) ASZ79_02375 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) ASZ79_02376 ENOG4105EN6 Membrane ASZ79_02377 ENOG4105EJ9 Membrane ASZ79_02378 ENOG4107RRE RNA-directed DNA polymerase ASZ79_02382 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain ASZ79_02383 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain ASZ79_02385 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) ASZ79_02386 ENOG4105M6F mutator MutT protein ASZ79_02387 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving ASZ79_02389 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) ASZ79_02390 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) ASZ79_02391 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) ASZ79_02392 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) ASZ79_02393 ENOG4105DFU Cell wall formation (By similarity) ASZ79_02394 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) ASZ79_02396 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) ASZ79_02397 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) ASZ79_02398 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) ASZ79_02399 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) ASZ79_02400 ENOG4105CJN penicillin-binding protein ASZ79_02401 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) ASZ79_02402 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) ASZ79_02403 ENOG4107QN2 dihydrolipoyl dehydrogenase ASZ79_02404 ENOG4107QSN dihydrolipoamide acetyltransferase ASZ79_02405 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) ASZ79_02406 ENOG41073TP transcriptional regulator ASZ79_02407 ENOG4105CGH 5'-nucleotidase ASZ79_02408 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) ASZ79_02409 ENOG4105T95 Thiol disulfide interChange protein ASZ79_02410 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ASZ79_02411 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) ASZ79_02413 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase ASZ79_02415 ENOG4107QHF type ii secretion system protein e ASZ79_02416 ENOG4105D7Q type ii secretion system ASZ79_02417 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) ASZ79_02418 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) ASZ79_02419 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) ASZ79_02420 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) ASZ79_02421 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ASZ79_02422 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ASZ79_02423 ENOG4105IPS esterase ASZ79_02424 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) ASZ79_02425 ENOG4108SX3 cytoplasmic protein ASZ79_02426 ENOG41087AY ADP-Ribose pyrophosphatase ASZ79_02427 ENOG4105DFG type I secretion outer membrane protein ASZ79_02429 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) ASZ79_02430 ENOG4105C8Q Methyl-accepting chemotaxis ASZ79_02431 ENOG4105I7R Adenylate cyclase ASZ79_02432 ENOG4107IX6 phosphate transport regulator ASZ79_02433 ENOG4105CJ3 phosphate transporter ASZ79_02434 ENOG4106MWK domain protein ASZ79_02437 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate ASZ79_02438 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) ASZ79_02439 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) ASZ79_02441 ENOG4105DXN mazG family ASZ79_02442 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) ASZ79_02443 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) ASZ79_02444 ENOG4105BZU Histidine kinase ASZ79_02445 ENOG4108K0B C-di-gmp phosphodiesterase ASZ79_02448 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) ASZ79_02449 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) ASZ79_02450 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) ASZ79_02451 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) ASZ79_02452 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) ASZ79_02453 ENOG4105C3F Signal peptidase i ASZ79_02454 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) ASZ79_02455 ENOG4105WMJ Positive regulator of sigma E, RseC MucC ASZ79_02456 ENOG4105VQK sigma E regulatory protein, MucB RseB ASZ79_02458 ENOG4105EMN RNA polymerase sigma factor ASZ79_02459 ENOG4108IYU L-aspartate oxidase ASZ79_02461 ENOG4105Y75 tpr repeat protein ASZ79_02462 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) ASZ79_02464 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family ASZ79_02465 ENOG4105D0A hydroxylase ASZ79_02467 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) ASZ79_02468 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase ASZ79_02469 ENOG4105E66 phosphoriboisomerase A ASZ79_02470 ENOG4108JQ1 Dehydrogenase ASZ79_02471 ENOG4108ZP8 Acetolactate synthase small subunit ASZ79_02472 ENOG4105C7K acetolactate synthase ASZ79_02473 ENOG4108IQE Amp-dependent synthetase and ligase ASZ79_02474 ENOG41064T2 transcriptional regulator, lysR family ASZ79_02478 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) ASZ79_02479 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) ASZ79_02480 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) ASZ79_02481 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) ASZ79_02490 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase ASZ79_02493 ENOG4108K5H permease YjgP YjgQ family protein ASZ79_02494 ENOG4108M8S permease YjgP YjgQ family protein ASZ79_02495 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) ASZ79_02496 ENOG4105MYG DNA polymerase iii, chi subunit ASZ79_02497 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) ASZ79_02498 ENOG4105C5I Dehydrogenase ASZ79_02499 ENOG4105D3G Pseudouridine synthase ASZ79_02500 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) ASZ79_02502 ENOG4108IAB Phoh family ASZ79_02503 ENOG4105DBV ornithine carbamoyltransferase ASZ79_02504 ENOG4105CXT aspartate transcarbamylase ASZ79_02505 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) ASZ79_02507 ENOG4105KME endoribonuclease L-psp ASZ79_02508 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase ASZ79_02509 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) ASZ79_02510 ENOG4105VFK BolA family ASZ79_02512 ENOG4105E3I toluene tolerance ASZ79_02513 ENOG4107PE3 Mammalian cell entry related domain protein ASZ79_02514 ENOG4105CY3 ABC transporter, permease ASZ79_02515 ENOG4105DHJ ABC, transporter ASZ79_02517 ENOG4105C2X Arabinose 5-phosphate isomerase ASZ79_02518 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase ASZ79_02520 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA ASZ79_02521 ENOG4108IUZ ABC transporter ASZ79_02522 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ASZ79_02523 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA ASZ79_02524 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN ASZ79_02525 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) ASZ79_02526 ENOG41080Z8 PHOSPHOCARRIER protein ASZ79_02527 ENOG4105CJW magnesium transporter ASZ79_02528 ENOG4105CMS peptidase U62, modulator of DNA gyrase ASZ79_02529 ENOG4105N42 UPF0307 protein ASZ79_02530 ENOG4107T0D ABC, transporter ASZ79_02531 ENOG4106SMU thiamine transporter membrane protein ASZ79_02532 ENOG4105DP9 ABC transporter ASZ79_02533 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase ASZ79_02534 ENOG4105DFU Cell wall formation (By similarity) ASZ79_02535 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 ASZ79_02536 ENOG4105F0N pyrophosphate phospho-hydrolase ASZ79_02537 ENOG41066HZ AIG2-like family ASZ79_02539 ENOG4105CFU surface antigen ASZ79_02540 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) ASZ79_02541 ENOG4108UUE Transcriptional regulator ASZ79_02544 ENOG4105C19 ABC transporter ASZ79_02548 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) ASZ79_02549 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) ASZ79_02550 ENOG4105C11 sulfate adenylyltransferase), subunit 2 ASZ79_02551 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) ASZ79_02552 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic ASZ79_02554 ENOG4105C1J atp-dependent rna helicase ASZ79_02555 ENOG4107YB6 acetyltransferase, (GNAT) family ASZ79_02556 ENOG4108SXK Transporter Drug Metabolite Exporter family ASZ79_02558 ENOG4108V1T peptidylprolyl cis-trans isomerase ASZ79_02560 ENOG4108ZT0 50S ribosomal protein l17 ASZ79_02561 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ASZ79_02562 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) ASZ79_02563 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) ASZ79_02564 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits ASZ79_02566 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) ASZ79_02567 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) ASZ79_02568 ENOG4105VPB 50S ribosomal protein L30 ASZ79_02569 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) ASZ79_02570 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) ASZ79_02571 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) ASZ79_02572 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) ASZ79_02573 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) ASZ79_02574 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits ASZ79_02575 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) ASZ79_02576 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) ASZ79_02577 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal ASZ79_02578 ENOG41083MP 50s ribosomal protein l29 ASZ79_02579 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) ASZ79_02580 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) ASZ79_02581 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) ASZ79_02582 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) ASZ79_02583 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity ASZ79_02584 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) ASZ79_02585 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) ASZ79_02586 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) ASZ79_02587 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) ASZ79_02588 ENOG4105C2N RNA methyltransferase TrmH family group 3 ASZ79_02589 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) ASZ79_02590 ENOG4105E68 Sulfatase ASZ79_02591 ENOG4108UV7 flagellar protein motX ASZ79_02593 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis ASZ79_02594 ENOG4105D44 asparaginase ASZ79_02595 ENOG4108YZY peptidylprolyl cis-trans isomerase ASZ79_02598 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein ASZ79_02599 ENOG4105C5H ABC transporter ASZ79_02601 ENOG4105DNZ Alpha Beta Hydrolase ASZ79_02603 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) ASZ79_02604 ENOG4107RYR Transcriptional regulator, Crp Fnr family ASZ79_02606 ENOG4105C26 Dehydrogenase ASZ79_02608 ENOG4105C8Y Acetylornithine aminotransferase ASZ79_02609 ENOG4105DDQ anthranilate synthase ASZ79_02610 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) ASZ79_02613 ENOG4105C31 Tryptophanyl-tRNA synthetase ASZ79_02614 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) ASZ79_02615 ENOG4105DJV ribulose-phosphate 3-epimerase ASZ79_02616 ENOG4105DFE Dna adenine methylase ASZ79_02618 ENOG4105D49 3-dehydroquinate synthase ASZ79_02619 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) ASZ79_02620 ENOG4105E4G Type IV pilus ASZ79_02625 ENOG4108JQC penicillin-binding protein 1A ASZ79_02627 ENOG4105EHV domain protein ASZ79_02628 ENOG4107QN2 dihydrolipoyl dehydrogenase ASZ79_02630 ENOG4105CH7 arginosuccinase ASZ79_02631 ENOG4105CDH Citrulline--aspartate ligase ASZ79_02632 ENOG4105CAS nag kinase ASZ79_02633 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase ASZ79_02634 ENOG4105CWC Acetylornithine deacetylase ASZ79_02635 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) ASZ79_02638 ENOG4105D7W serine acetyltransferase ASZ79_02639 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase ASZ79_02640 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) ASZ79_02641 ENOG4107YZP Rhodanese domain protein ASZ79_02642 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) ASZ79_02644 ENOG4105E33 succinate dehydrogenase ASZ79_02645 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) ASZ79_02646 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) ASZ79_02647 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) ASZ79_02648 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein ASZ79_02650 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) ASZ79_02651 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) ASZ79_02656 ENOG4105CP7 Triose-phosphate isomerase ASZ79_02658 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) ASZ79_02659 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase ASZ79_02660 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) ASZ79_02661 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) ASZ79_02662 ENOG41063M6 Cell Division Protein ASZ79_02664 ENOG4105ETE Transcriptional regulator (LacI family ASZ79_02665 ENOG4105C25 Primosomal protein n' ASZ79_02666 ENOG4105VFB Binds the 23S rRNA (By similarity) ASZ79_02668 ENOG4105C6K Malic enzyme ASZ79_02669 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) ASZ79_02670 ENOG4105C28 cystathionine ASZ79_02671 ENOG4105CFH Aspartokinase ASZ79_02672 ENOG4105SYT Methylenetetrahydrofolate reductase ASZ79_02673 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) ASZ79_02674 ENOG4105CBT Fructose-1,6-bisphosphatase ASZ79_02675 ENOG4105CTQ phosphohexokinase ASZ79_02676 ENOG41076HS cation diffusion facilitator family transporter ASZ79_02678 ENOG4105E3W Two component transcriptional regulator (Winged helix family ASZ79_02679 ENOG4105E0F Histidine kinase ASZ79_02681 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) ASZ79_02682 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 ASZ79_02683 ENOG4105BZU Histidine kinase ASZ79_02684 ENOG4108IJ0 Aspartate ammonia-lyase ASZ79_02685 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter ASZ79_02689 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) ASZ79_02691 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) ASZ79_02693 ENOG4107QN1 sodium solute ASZ79_02694 ENOG4105EX9 Membrane ASZ79_02695 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) ASZ79_02696 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) ASZ79_02697 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) ASZ79_02698 ENOG4105CB5 ATP-dependent DNA helicase recG ASZ79_02699 ENOG4105C2W permease ASZ79_02700 ENOG4105E0F Histidine kinase ASZ79_02701 ENOG4105DPZ Two component transcriptional regulator (Winged helix family ASZ79_02702 ENOG4108RRZ Transcription elongation factor GreB ASZ79_02703 ENOG4105BZM domain protein ASZ79_02705 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) ASZ79_02707 ENOG4105MJ2 Competence protein ASZ79_02708 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) ASZ79_02709 ENOG4107RK2 ADP-ribose diphosphatase NudE ASZ79_02710 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase ASZ79_02711 ENOG4105PIC general secretion pathway protein N ASZ79_02712 ENOG4105U1E general secretion pathway protein M ASZ79_02713 ENOG4108BY5 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) ASZ79_02714 ENOG4108RTD type II secretion system protein K ASZ79_02715 ENOG4108WWZ General secretion pathway protein J ASZ79_02716 ENOG4105X5Z General secretion pathway protein I ASZ79_02717 ENOG4105VWV general secretion pathway protein h ASZ79_02718 ENOG4108VAU general secretion pathway protein G ASZ79_02719 ENOG4105D7Q type ii secretion system ASZ79_02720 ENOG4107QHF type ii secretion system protein e ASZ79_02722 ENOG4108XKW General secretion pathway protein C ASZ79_02723 ENOG4105VEJ Heat shock protein ASZ79_02724 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) ASZ79_02725 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase ASZ79_02727 ENOG4105SUU thioesterase domain ASZ79_02728 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) ASZ79_02733 ENOG4105C5F glutamine synthetase ASZ79_02735 ENOG4105CUX Signal transduction histidine kinase ASZ79_02736 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASZ79_02737 ENOG4105BZU Histidine kinase ASZ79_02738 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) ASZ79_02754 ENOG4108RR8 protoporphyrinogen oxidase ASZ79_02755 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) ASZ79_02756 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein ASZ79_02757 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ASZ79_02758 ENOG4105CHU acetyl-coa acetyltransferase ASZ79_02759 ENOG4105F52 Transcriptional regulator ASZ79_02760 ENOG4105CZQ inner membrane transport protein YdhC ASZ79_02761 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) ASZ79_02762 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) ASZ79_02763 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) ASZ79_02764 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) ASZ79_02765 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) ASZ79_02766 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) ASZ79_02767 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) ASZ79_02768 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) ASZ79_02769 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) ASZ79_02770 ENOG410684E atp synthase ASZ79_02771 ENOG4105FA0 parb-like partition protein ASZ79_02772 ENOG4107QJE Chromosome Partitioning Protein ASZ79_02773 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) ASZ79_02774 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) ASZ79_02786 ENOG4105CDY transcriptional regulatory protein ASZ79_02787 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase ASZ79_02788 ENOG4105C8Q Methyl-accepting chemotaxis ASZ79_02789 ENOG4108YYI Protein of unknown function (DUF2810) ASZ79_02790 ENOG41061ZR Transcriptional regulator ASZ79_02791 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) ASZ79_02792 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) ASZ79_02793 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) ASZ79_02794 ENOG4108WC9 type VI secretion system effector, hcp1 family ASZ79_02795 ENOG4105CS6 Rhs element vgr protein ASZ79_02800 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ASZ79_02802 ENOG4105C8P )-transporter ASZ79_02803 ENOG4108Q67 UPF0319 protein ASZ79_02808 ENOG4105C8Q Methyl-accepting chemotaxis ASZ79_02812 ENOG4105EYK Phosphatidylglycerophosphatase B ASZ79_02813 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) ASZ79_02819 ENOG4105D6U Sodium Glutamate Symporter ASZ79_02820 ENOG4105YE1 PilZ domain ASZ79_02823 ENOG4105EFX secretion protein, HlyD family ASZ79_02824 ENOG4105KK7 inner membrane protein YiaW ASZ79_02825 ENOG4106TD9 Diguanylate cyclase ASZ79_02828 ENOG4105D3A purine nucleoside phosphorylase DeoD-type ASZ79_02830 ENOG4107SEY Conserved Protein ASZ79_02832 ENOG4105CVP deoxyribo-dipyrimidine photolyase ASZ79_02833 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein ASZ79_02836 ENOG4105C1J atp-dependent rna helicase ASZ79_02837 ENOG4105CUG Oligopeptidase b ASZ79_02843 ENOG4105CVA phosphate ASZ79_02844 ENOG4105C8U phosphate abc transporter ASZ79_02845 ENOG4105E2Z phosphate ABC transporter (Permease ASZ79_02846 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) ASZ79_02847 ENOG4105BZU Histidine kinase ASZ79_02849 ENOG4105DWD nucleoside recognition domain protein ASZ79_02850 ENOG4105CHH sulfate transporter ASZ79_02852 ENOG4105DR5 peptidase ASZ79_02853 ENOG4105BZU Histidine kinase ASZ79_02854 ENOG4105EQ2 LysR family Transcriptional regulator ASZ79_02855 ENOG4105E5M Multidrug resistance protein D ASZ79_02856 ENOG4108Z4X TRANSCRIPTIONal ASZ79_02860 ENOG4105CK2 sodium dicarboxylate symporter ASZ79_02870 ENOG4107RH7 Nicotinate phosphoribosyltransferase ASZ79_02871 ENOG4105D9R oxidoreductase ASZ79_02873 ENOG4105BZU Histidine kinase ASZ79_02874 ENOG4107VXZ Hydrolase ASZ79_02876 ENOG4105D3G Pseudouridine synthase ASZ79_02889 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ASZ79_02890 ENOG4108JUB Transcriptional regulator ASZ79_02895 ENOG4105CS6 Rhs element vgr protein ASZ79_02899 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) ASZ79_02900 ENOG4105C2J ABC transporter ASZ79_02901 ENOG4105CNN ABC, transporter ASZ79_02902 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator ASZ79_02903 ENOG4108RVA ribokinase ASZ79_02904 ENOG4105ETE Transcriptional regulator (LacI family ASZ79_02905 ENOG4106Z1T Nicotinamide Mononucleotide Transporter ASZ79_02906 ENOG4106Z1T Nicotinamide Mononucleotide Transporter ASZ79_02907 ENOG4108I5U Uridine phosphorylase ASZ79_02909 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase ASZ79_02910 ENOG4105CXY transporter ASZ79_02913 ENOG4105CQZ Histidine kinase ASZ79_02914 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ASZ79_02919 ENOG4105D5U fad dependent oxidoreductase ASZ79_02921 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) ASZ79_02923 ENOG4105KJM monovalent cation h antiporter subunit g ASZ79_02924 ENOG41080TA Multiple resistance and ph regulation protein f ASZ79_02925 ENOG4105SC1 monovalent cation H antiporter subunit E ASZ79_02926 ENOG4108JPZ Monovalent cation H antiporter subunit D ASZ79_02927 ENOG4105MKQ Monovalent cation H antiporter subunit C ASZ79_02928 ENOG4105D65 subunit l ASZ79_02930 ENOG4105Q9Y Universal stress protein ASZ79_02931 ENOG4105CIC tryptophan-specific transport protein ASZ79_02932 ENOG4105C0F tryptophanase EC 4.1.99.1 ASZ79_02936 ENOG4105VRT cytoplasmic protein ASZ79_02938 ENOG4105BZU Histidine kinase ASZ79_02939 ENOG4105VEQ Cold shock protein ASZ79_02947 ENOG4105C7R Atpase associated with various cellular activities aaa_3 ASZ79_02949 ENOG41069D7 Methyl-accepting chemotaxis ASZ79_02953 ENOG4105D9N nucleoside ASZ79_02955 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) ASZ79_02957 ENOG4108JUA Transcriptional regulator ASZ79_02958 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) ASZ79_02959 ENOG4105VEQ Cold shock protein ASZ79_02964 ENOG4108UNF response regulator ASZ79_02966 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) ASZ79_02967 ENOG4105C5I Dehydrogenase ASZ79_02972 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) ASZ79_02977 ENOG4108RS6 transposase ASZ79_02979 ENOG4105C1J atp-dependent rna helicase ASZ79_02980 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter ASZ79_02982 ENOG4107RA1 nh(3)-dependent nad( ) synthetase ASZ79_02983 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) ASZ79_02984 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase ASZ79_02985 ENOG4105BZU Histidine kinase ASZ79_02987 ENOG4107S6Z Na H antiporter ASZ79_02988 ENOG4105E5M Multidrug resistance protein D ASZ79_02991 ENOG4105BZU Histidine kinase ASZ79_02992 ENOG4105KUU lipolytic protein G-D-S-L family ASZ79_02993 ENOG4106M3D hemolysin ASZ79_02994 ENOG4108N3W hemolysin secretion protein ASZ79_02995 ENOG4107IFA Lipase (EC 3.1.1.3) ASZ79_02997 ENOG4107G87 m6 family metalloprotease domain protein ASZ79_03002 ENOG4105DHS permease protein ASZ79_03003 ENOG4105CM4 permease protein ASZ79_03004 ENOG4108IPW abc transporter atp-binding protein ASZ79_03008 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) ASZ79_03012 ENOG4105ETX regulatoR ASZ79_03014 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase ASZ79_03016 ENOG410667J hydrolase ASZ79_03022 ENOG4105DS1 cytochrome b561 ASZ79_03028 ENOG4105XJC Two component transcriptional regulator (Winged helix family ASZ79_03029 ENOG4105BZU Histidine kinase ASZ79_03036 ENOG4107QVI Methyltransferase, type 11 ASZ79_03039 ENOG4105C2C drug resistance transporter, Bcr CflA ASZ79_03040 ENOG4105C8Q Methyl-accepting chemotaxis ASZ79_03042 ENOG4105DZ1 carboxypeptidase ASZ79_03048 ENOG4108RS6 transposase ASZ79_03049 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor ASZ79_03051 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) ASZ79_03052 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) ASZ79_03054 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) ASZ79_03056 ENOG4105F2I Transposase ASZ79_03061 ENOG4105C22 threonyL-tRNA synthetase ASZ79_03062 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) ASZ79_03063 ENOG41082NX 50s ribosomal protein l35 ASZ79_03064 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) ASZ79_03071 ENOG4105YGK Pfam:UPF0157 ASZ79_03075 ENOG4105CYX Short-chain dehydrogenase reductase Sdr ASZ79_03079 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase ASZ79_03090 ENOG4105YGK Pfam:UPF0157 ASZ79_03122 ENOG4105EST Metal Dependent Phosphohydrolase ASZ79_03143 ENOG4105CYX Short-chain dehydrogenase reductase Sdr ASZ79_03144 ENOG4105YGK Pfam:UPF0157 ASZ79_03152 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein ASZ79_03157 ENOG4105YGK Pfam:UPF0157 ASZ79_03160 ENOG4105D9U N-acetyltransferase ASZ79_03162 ENOG4105QNF Outer membrane lipoprotein ASZ79_03168 ENOG4105VXN addiction module toxin, RelE StbE family ASZ79_03173 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase ASZ79_03186 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A ASZ79_03188 ENOG4105YGK Pfam:UPF0157 ASZ79_03192 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase ASZ79_03200 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase ASZ79_03204 ENOG4105QNF Outer membrane lipoprotein ASZ79_03208 ENOG4105YGK Pfam:UPF0157 ASZ79_03209 ENOG4105N14 lysine exporter protein LysE YggA ASZ79_03244 ENOG4105YGK Pfam:UPF0157 ASZ79_03249 ENOG41080ET plasmid maintenance system killer protein ASZ79_03250 ENOG4105VDM plasmid maintenance system antidote protein, xre family ASZ79_03252 ENOG4108S58 Phenazine biosynthesis protein PhzF ASZ79_03259 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase ASZ79_03266 ENOG4105QNF Outer membrane lipoprotein ASZ79_03276 ENOG4105YGK Pfam:UPF0157 ASZ79_03278 ENOG4105D9U N-acetyltransferase ASZ79_03282 ENOG4108S58 Phenazine biosynthesis protein PhzF ASZ79_03291 ENOG4105YGK Pfam:UPF0157 ASZ79_03296 ENOG4108S58 Phenazine biosynthesis protein PhzF ASZ79_03302 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A ASZ79_03307 ENOG4105QNF Outer membrane lipoprotein ASZ79_03319 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein ASZ79_03330 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase ASZ79_03334 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system ASZ79_03335 ENOG4105W08 virulence gene repressor rsal ASZ79_03338 ENOG4105F2I Transposase ASZ79_03339 ENOG4105EQK -acetyltransferase ASZ79_03342 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase ASZ79_03359 ENOG4108RS6 transposase ASZ79_03370 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase ASZ79_03375 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase ASZ79_03376 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) ASZ79_03377 ENOG4105CGF Aromatic amino acid aminotransferase ASZ79_03378 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) ASZ79_03380 ENOG4105DM4 PTS System ASZ79_03381 ENOG4105DE4 1-phosphofructokinase ASZ79_03382 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein ASZ79_03383 ENOG4107B7Y DNA-binding transcriptional regulator FruR ASZ79_03384 ENOG4107RFY SbcCD D subunit ASZ79_03385 ENOG4105EYH Exonuclease ASZ79_03386 ENOG4108MGY Histidine kinase ASZ79_03387 ENOG4107KBT 8-Amino-7-oxononanoate synthase ASZ79_03389 ENOG4105CMQ Chloride channel ASZ79_03390 ENOG4105CKI cobalamin synthesis protein ASZ79_03391 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) ASZ79_03392 ENOG4105DFH Transport of potassium into the cell (By similarity) ASZ79_03393 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) ASZ79_03394 ENOG4105C08 Histidine kinase ASZ79_03395 ENOG4105EEX Two component transcriptional regulator (Winged helix family ASZ79_03396 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) ASZ79_03397 ENOG4108RHM integral membrane protein ASZ79_03400 ENOG4105EPM Diguanylate phosphodiesterase ASZ79_03402 ENOG4105DS1 cytochrome b561 ASZ79_03404 ENOG4105TMB Formate nitrite transporter ASZ79_03405 ENOG4105DUM transcriptional regulator, lysR family ASZ79_03406 ENOG4108UQ5 membrane protein YcdZ ASZ79_03407 ENOG4105CPB ATP-dependent endonuclease of the OLD family ASZ79_03408 ENOG4105CGH 5'-nucleotidase ASZ79_03409 ENOG4105DU1 integral membrane protein, terc ASZ79_03412 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA ASZ79_03419 ENOG4105BZU Histidine kinase ASZ79_03421 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) ASZ79_03423 ENOG4105BZU Histidine kinase ASZ79_03426 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) ASZ79_03427 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) ASZ79_03429 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ASZ79_03433 ENOG4108ZJT translation initiation factor, Sui1 ASZ79_03435 ENOG4105CPF Cell wall formation (By similarity) ASZ79_03437 ENOG4105CD5 CoA-binding domain protein ASZ79_03438 ENOG4105CWB LysR family transcriptional Regulator ASZ79_03443 ENOG4105KA0 thioesterase Superfamily protein ASZ79_03448 ENOG4105CYM Glutathione S-transferase ASZ79_03451 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) ASZ79_03452 ENOG4108JQ5 ABC transporter ASZ79_03453 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component ASZ79_03454 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component ASZ79_03455 ENOG4105E43 Extracellular solute-binding protein, family 5 ASZ79_03460 ENOG4105DUX Transporter ASZ79_03463 ENOG4107RCV ABC transporter, permease ASZ79_03466 ENOG4107STF Involved in phosphonate degradation (By similarity) ASZ79_03467 ENOG4108JPW Aminotransferase ASZ79_03468 ENOG4108KAZ Involved in phosphonate degradation (By similarity) ASZ79_03469 ENOG4105NXH GreA GreB family elongation factor ASZ79_03470 ENOG4105PAD Hydrolase ASZ79_03472 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain ASZ79_03475 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) ASZ79_03477 ENOG4105CKU formyltetrahydrofolate synthetase ASZ79_03478 ENOG4105E0X reductase ASZ79_03479 ENOG4105EUJ GTP cyclohydrolase i ASZ79_03480 ENOG4105CVM Molybdenum cofactor synthesis domain protein ASZ79_03481 ENOG4105D06 uba thif-type nad fad binding protein ASZ79_03483 ENOG4105KHC sulfurtransferase ASZ79_03484 ENOG4107RHR regulatoR ASZ79_03485 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) ASZ79_03486 ENOG4105CV1 Transketolase (EC 2.2.1.1) ASZ79_03492 ENOG4108M3J Dehydrogenase ASZ79_03495 ENOG4105RA2 Membrane ASZ79_03498 ENOG4105ETT transcriptional Regulator, LysR family ASZ79_03499 ENOG41067V3 Antibiotic biosynthesis monooxygenase ASZ79_03500 ENOG4108RCM Nitroreductase ASZ79_03505 ENOG41080HT Transcriptional regulator, arsr family ASZ79_03507 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase ASZ79_03516 ENOG4105C5Y PTS System ASZ79_03517 ENOG4105ETE Transcriptional regulator (LacI family ASZ79_03518 ENOG4107R3K hydrolase ASZ79_03519 ENOG4105D7K pfkb domain protein ASZ79_03520 ENOG4105C6V Glycerol-3-phosphate dehydrogenase ASZ79_03521 ENOG4108NVR Methyl-accepting chemotaxis ASZ79_03522 ENOG4108ZG0 Ompa motb domain protein ASZ79_03523 ENOG4108V1T peptidylprolyl cis-trans isomerase ASZ79_03524 ENOG4107VXZ Hydrolase ASZ79_03525 ENOG4108N3W hemolysin secretion protein ASZ79_03526 ENOG4105CEE C4-dicarboxylate transporter ASZ79_03527 ENOG4105EJQ L-serine dehydratase ASZ79_03532 ENOG4105ETE Transcriptional regulator (LacI family ASZ79_03533 ENOG4105WH1 Two component transcriptional regulator luxr family ASZ79_03534 ENOG4105BZU Histidine kinase ASZ79_03537 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ASZ79_03541 ENOG4105DHT Metal Dependent Phosphohydrolase ASZ79_03542 ENOG4108KX4 response regulator ASZ79_03543 ENOG4105BZU Histidine kinase ASZ79_03544 ENOG4105CXY transporter ASZ79_03545 ENOG4105C4Y ABC transporter ASZ79_03546 ENOG4107RCV ABC transporter, permease ASZ79_03547 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ASZ79_03548 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class ASZ79_03550 ENOG4105CHU acetyl-coa acetyltransferase ASZ79_03552 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ASZ79_03553 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ASZ79_03556 ENOG4105BZU Histidine kinase ASZ79_03557 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) ASZ79_03560 ENOG4108I6A alcohol dehydrogenase ASZ79_03562 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta ASZ79_03564 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC ASZ79_03566 ENOG4105CXY transporter ASZ79_03567 ENOG4105CA9 Pyruvate kinase ASZ79_03568 ENOG4105BZU Histidine kinase ASZ79_03569 ENOG4108SV3 Tmao reductase system periplasmic protein tort ASZ79_03570 ENOG4108Z5K methylglyoxal synthase ASZ79_03571 ENOG4108RWI nicotinamidase ASZ79_03573 ENOG41080IJ Diacylglycerol kinase ASZ79_03576 ENOG41088T4 Helicase IV ASZ79_03577 ENOG4105EM2 membrane ASZ79_03583 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) ASZ79_03584 ENOG4105E0C molybdate abc transporter ASZ79_03585 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein ASZ79_03586 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) ASZ79_03595 ENOG4105BZU Histidine kinase ASZ79_03596 ENOG4108QGH periplasmic ASZ79_03598 ENOG41082IR Excinuclease ABC C subunit domain protein ASZ79_03605 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) ASZ79_03606 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) ASZ79_03608 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A ASZ79_03609 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B ASZ79_03610 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) ASZ79_03611 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) ASZ79_03612 ENOG4105K63 Thioredoxin ASZ79_03619 ENOG4105DUM transcriptional regulator, lysR family ASZ79_03620 ENOG4105DMR ABC, transporter ASZ79_03621 ENOG4105GBT ABC transporter ASZ79_03622 ENOG4106PMH Extracellular solute-binding protein family 3 ASZ79_03623 ENOG4105E5Z arginine transporter ATP-binding subunit ASZ79_03625 ENOG4105EV2 VWA domain protein interacting with AAA ATPase ASZ79_03627 ENOG4108YZ4 nudix hydrolase ASZ79_03628 ENOG4105C5W Aldolase ASZ79_03629 ENOG4106RE7 Cytochrome ASZ79_03630 ENOG4108IG5 Transcriptional regulator ASZ79_03631 ENOG4105C1J atp-dependent rna helicase ASZ79_03632 ENOG4108ZYK Acyl carrier protein phosphodiesterase ASZ79_03634 ENOG4105E0U tyrosine-specific transport protein ASZ79_03635 ENOG4108N3W hemolysin secretion protein ASZ79_03637 ENOG4105CMR udp-glucose 4-epimerase ASZ79_03638 ENOG4105E7W lamb ycsf family protein ASZ79_03640 ENOG4107R7A Allophanate hydrolase subunit 2 ASZ79_03642 ENOG4105C6Y Udp-glucose 6-dehydrogenase ASZ79_03644 ENOG4105CV6 ABC transporter, permease ASZ79_03645 ENOG4108I0Y (ABC) transporter ASZ79_03647 ENOG4105RKW reductase (By ASZ79_03650 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) ASZ79_03659 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) ASZ79_03662 ENOG4107RE1 Inosine-guanosine kinase ASZ79_03663 ENOG4105E0M Sulfatase ASZ79_03665 ENOG4105C1J atp-dependent rna helicase ASZ79_03666 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) ASZ79_03668 ENOG4105CVA phosphate ASZ79_03670 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein ASZ79_03672 ENOG4108M1A Chitin-binding protein ASZ79_03673 ENOG4105D4Y metalloprotease ASZ79_03675 ENOG4105CYW agmatinase ASZ79_03676 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) ASZ79_03679 ENOG4105CJW magnesium transporter ASZ79_03680 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) ASZ79_03681 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) ASZ79_03683 ENOG4105CZK Aspartate kinase ASZ79_03684 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) ASZ79_03685 ENOG4108JPW Aminotransferase ASZ79_03686 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase ASZ79_03688 ENOG41090A4 Pterin carbinolamine dehydratase ASZ79_03689 ENOG4105MIR Phenylalanine 4-monooxygenase ASZ79_03690 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ASZ79_03693 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) ASZ79_03694 ENOG4105EGI Transcriptional regulator ASZ79_03697 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) ASZ79_03698 ENOG4105C37 (CBS) domain ASZ79_03699 ENOG4108UKZ OsmC family ASZ79_03701 ENOG4107YWA deoxycytidylate deaminase ASZ79_03708 ENOG4105DVH amino acid ASZ79_03709 ENOG4106TD9 Diguanylate cyclase ASZ79_03711 ENOG4108VAC response regulator ASZ79_03712 ENOG4108HRK Histidine kinase ASZ79_03715 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ASZ79_03716 ENOG4105C19 ABC transporter ASZ79_03720 ENOG4107RGM aldo keto reductase ASZ79_03721 ENOG4107T9C Alpha amylase catalytic region ASZ79_03724 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation ASZ79_03725 ENOG4108M0H Extracellular lipase ASZ79_03726 ENOG4107SDU Methyl-accepting chemotaxis ASZ79_03727 ENOG4105D4Y metalloprotease ASZ79_03728 ENOG4105EIF outer membrane protein W ASZ79_03730 ENOG41061WM D-Alanyl-D-Alanine ASZ79_03731 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ASZ79_03733 ENOG4105C4M (Ubiquinol oxidase) subunit I ASZ79_03734 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ASZ79_03737 ENOG4105BZC d-serine deaminase ASZ79_03738 ENOG4105W8I Transcriptional regulator ASZ79_03748 ENOG4105CPQ Dehydrogenase ASZ79_03749 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) ASZ79_03750 ENOG4105TMR Functions as a holding molecular chaperone (holdase) which stabilizes unfolding intermediates and rapidly releases them in an active form once stress has abated. Plays an important role in protecting cells from severe heat shock and starvation, as well as in acid resistance of stationary-phase cells. It catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step (By similarity) ASZ79_03752 ENOG4105EXG Transcriptional regulator ASZ79_03753 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase ASZ79_03757 ENOG4107SSZ Phosphatase ASZ79_03758 ENOG4105DHT Metal Dependent Phosphohydrolase ASZ79_03759 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase ASZ79_03760 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) ASZ79_03761 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) ASZ79_03766 ENOG4105BZW Glycerate kinase ASZ79_03767 ENOG4105C6Z Gluconate ASZ79_03768 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR ASZ79_03769 ENOG4108NVR Methyl-accepting chemotaxis ASZ79_03770 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related ASZ79_03771 ENOG41090JE Utilization Protein ASZ79_03772 ENOG4105D4P Coproporphyrinogen iii oxidase ASZ79_03773 ENOG4105WQ5 TonB family ASZ79_03774 ENOG41090AP transport protein ASZ79_03775 ENOG4106GFD transport protein ASZ79_03776 ENOG4107R4I Periplasmic binding protein ASZ79_03777 ENOG4105EHG Permease protein ASZ79_03778 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) ASZ79_03784 ENOG4105C8Q Methyl-accepting chemotaxis ASZ79_03785 ENOG4105QVC MOSC domain-containing protein ASZ79_03785 ENOG4105QVC MOSC domain-containing protein ASZ79_03786 ENOG4105EKE dihydroorotase ASZ79_03788 ENOG4105KAF membrAne ASZ79_03790 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) ASZ79_03791 ENOG4105CKW Inner membrane protein yedI ASZ79_03792 ENOG4108ESY Metal dependent phosphohydrolase ASZ79_03794 ENOG4105VEQ Cold shock protein ASZ79_03799 ENOG4105BZU Histidine kinase ASZ79_03800 ENOG4105E98 transcriptional regulator DeoR family ASZ79_03803 ENOG4105EG2 ABC transporter, permease ASZ79_03804 ENOG4105D56 permease protein ASZ79_03805 ENOG4107FKK extracellular solute-binding protein family 1 ASZ79_03806 ENOG4108IJ9 (ABC) transporter ASZ79_03807 ENOG4108HK0 -acetyltransferase ASZ79_03810 ENOG4105K8R UPF0145 protein ASZ79_03811 ENOG41086KC Transcriptional regulator ASZ79_03812 ENOG4105KQ5 peptidylprolyl cis-trans isomerase ASZ79_03813 ENOG4107R88 Chemotaxis protein (CheV) ASZ79_03814 ENOG4105K56 Transcriptional regulator ASZ79_03815 ENOG4106TD9 Diguanylate cyclase ASZ79_03819 ENOG4105BZU Histidine kinase ASZ79_03823 ENOG4105ETT transcriptional Regulator, LysR family ASZ79_03824 ENOG4108K0B C-di-gmp phosphodiesterase ASZ79_03826 ENOG4105EUB pirin domain protein ASZ79_03827 ENOG4105NBK UPF0345 protein ASZ79_03829 ENOG4105E5W Transporter ASZ79_03831 ENOG4105C8Q Methyl-accepting chemotaxis ASZ79_03833 ENOG4105DAN ATP-dependent protease ASZ79_03835 ENOG4108JQ5 ABC transporter ASZ79_03836 ENOG4105E89 ABC transporter ASZ79_03837 ENOG4105C8Q Methyl-accepting chemotaxis ASZ79_03839 ENOG4105CC0 LysR family Transcriptional regulator ASZ79_03841 ENOG4105DAA L-lactate ASZ79_03842 ENOG4105DMF Dehydrogenase ASZ79_03844 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) ASZ79_03846 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor ASZ79_03848 ENOG4105C1J atp-dependent rna helicase ASZ79_03850 ENOG4105CR8 Transcriptional regulator ASZ79_03852 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ASZ79_03854 ENOG4105BZ1 (ABC) transporter ASZ79_03856 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ASZ79_03863 ENOG4105K56 Transcriptional regulator ASZ79_03864 ENOG4108ZHJ Organic hydroperoxide resistance protein ASZ79_03867 ENOG4108SXK Transporter Drug Metabolite Exporter family ASZ79_03868 ENOG4105VW4 glutaredoxin 3 ASZ79_03869 ENOG4108P2H Inner membrane protein YjiG ASZ79_03870 ENOG41074DU domain protein ASZ79_03871 ENOG4105DN9 Na H antiporter ASZ79_03873 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) ASZ79_03874 ENOG4105D03 DNA-3-methyladenine glycosylase II ASZ79_03875 ENOG4108VGI doxx family ASZ79_03880 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) ASZ79_03882 ENOG4107W52 maltose operon periplasmic protein ASZ79_03883 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) ASZ79_03886 ENOG4108N3W hemolysin secretion protein ASZ79_03889 ENOG4105C8Q Methyl-accepting chemotaxis ASZ79_03891 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) ASZ79_03892 ENOG4105CDA abc transporter atp-binding protein ASZ79_03894 ENOG4106TNF Periplasmic binding protein ASZ79_03895 ENOG4105EZ7 amino acid ABC transporter ASZ79_03896 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain ASZ79_03898 ENOG4105DR5 peptidase ASZ79_03900 ENOG4105CTS PTS system mannitol-specific ASZ79_03901 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase ASZ79_03902 ENOG4105E61 Mannitol repressor protein ASZ79_03903 ENOG4105EP9 oxidoreductase ASZ79_03909 ENOG4108RYK Nad-dependent epimerase dehydratase ASZ79_03910 ENOG4105JQN Transcriptional regulator ASZ79_03911 ENOG41069D7 Methyl-accepting chemotaxis ASZ79_03912 ENOG4105EMU Dehydrogenase ASZ79_03913 ENOG4105JQN Transcriptional regulator ASZ79_03915 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) ASZ79_03917 ENOG4105D5Q Arginine ornithine antiporter ASZ79_03918 ENOG4105CXN decarboxylase ASZ79_03922 ENOG4107RGH Aldehyde dehydrogenase ASZ79_03923 ENOG4105EW9 transcriptional regulator AsnC family ASZ79_03924 ENOG4105C8Q Methyl-accepting chemotaxis ASZ79_03926 ENOG4105CK7 Sodium proline symporter ASZ79_03928 ENOG4105C26 Dehydrogenase ASZ79_03932 ENOG4105E6M Sulphatase-modifying factor protein ASZ79_03934 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) ASZ79_03935 ENOG4107QZV Type I secretion membrane fusion protein ASZ79_03938 ENOG4108JJA ABC, transporter ASZ79_03940 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ASZ79_03942 ENOG4105C8Q Methyl-accepting chemotaxis ASZ79_03943 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) ASZ79_03944 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) ASZ79_03945 ENOG4105BZU Histidine kinase ASZ79_03946 ENOG4105C8Q Methyl-accepting chemotaxis ASZ79_03947 ENOG4108V3W Chemotaxis protein, CheW ASZ79_03948 ENOG4108V3W Chemotaxis protein, CheW ASZ79_03949 ENOG4105CBS Chea signal transduction histidine kinase ASZ79_03950 ENOG4108VYJ response regulator receiver protein ASZ79_03953 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ASZ79_03954 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ASZ79_03955 ENOG4108JQ6 ABC transporter ASZ79_03956 ENOG4105DIJ Phosphoethanolamine transferase ASZ79_03957 ENOG4105DHQ Histidine kinase ASZ79_03958 ENOG4105XJC Two component transcriptional regulator (Winged helix family ASZ79_03964 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) ASZ79_03965 ENOG4107RUE extracellular solute-binding protein family 1 ASZ79_03966 ENOG4106RMF ParB family