locus-tag	class	description
AP033_10001	COG2271	Major facilitator Superfamily
AP033_10002	COG0584	glycerophosphoryl diester phosphodiesterase
AP033_10004	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AP033_10006	COG1609	Transcriptional regulator
AP033_10007	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AP033_10008	COG1879	ABC-type sugar transport system periplasmic component
AP033_10009	COG1172	Belongs to the binding-protein-dependent transport system permease family
AP033_10010	COG1129	ABC transporter
AP033_10011	COG1869	D-ribose catabolic process
AP033_10014	COG3501	Rhs element vgr protein
AP033_10033	COG0564	pseudouridine synthase activity
AP033_10035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AP033_10036	COG2771	luxR family
AP033_10036	COG2200	EAL domain
AP033_10037	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AP033_10038	COG0673	inositol 2-dehydrogenase activity
AP033_10039	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AP033_10045	COG1342	Belongs to the UPF0251 family
AP033_10048	COG1301	dicarboxylic acid transport
AP033_10053	COG2814	Major facilitator Superfamily
AP033_10054	COG0583	DNA-binding transcription factor activity
AP033_10055	COG5001	Diguanylate cyclase
AP033_10055	COG3300	MHYT domain
AP033_10056	COG0739	heme binding
AP033_10058	COG0659	secondary active sulfate transmembrane transporter activity
AP033_10061	COG0745	RESPONSE REGULATOR receiver
AP033_10061	COG3706	GGDEF domain
AP033_10062	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AP033_10063	COG0581	inorganic phosphate transmembrane transporter activity
AP033_10064	COG0573	inorganic phosphate transmembrane transporter activity
AP033_10065	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AP033_10071	COG1770	oligopeptidase
AP033_10072	COG0513	Belongs to the DEAD box helicase family
AP033_10074	COG1388	LysM domain
AP033_10074	COG1376	ErfK ybiS ycfS ynhG family protein
AP033_10075	COG0415	Belongs to the DNA photolyase family
AP033_10077	COG3272	Protein of unknown function (DUF1722)
AP033_10078	COG0813	purine-nucleoside phosphorylase activity
AP033_10081	COG3706	GGDEF domain
AP033_10083	COG1566	PFAM secretion protein HlyD family protein
AP033_10087	COG0786	glutamate:sodium symporter activity
AP033_10090	COG1999	signal sequence binding
AP033_10092	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AP033_10093	COG0671	phosphoesterase, PA-phosphatase related
AP033_10101	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AP033_10102	COG0471	metal ion transport
AP033_10109	COG3501	Rhs element vgr protein
AP033_10111	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AP033_10112	COG1640	4-alpha-glucanotransferase
AP033_10113	COG0058	SHG alpha-glucan phosphorylase activity
AP033_10114	COG2909	trisaccharide binding
AP033_10117	COG2084	Dehydrogenase
AP033_10118	COG0217	transcriptional regulatory protein
AP033_10125	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AP033_10126	COG1444	tRNA N-acetyltransferase activity
AP033_10132	COG0745	RESPONSE REGULATOR receiver
AP033_10133	COG0642	Histidine kinase
AP033_10134	COG2194	sulfuric ester hydrolase activity
AP033_10135	COG4608	Belongs to the ABC transporter superfamily
AP033_10136	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AP033_10137	COG0601	transmembrane transport
AP033_10141	COG2198	Histidine kinase
AP033_10141	COG0643	Histidine kinase
AP033_10142	COG0835	chemotaxis
AP033_10143	COG0835	chemotaxis
AP033_10144	COG0840	transmembrane signaling receptor activity
AP033_10145	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AP033_10146	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AP033_10150	COG0745	RESPONSE REGULATOR receiver
AP033_10156	COG0259	pyridoxamine-phosphate oxidase activity
AP033_10159	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AP033_10164	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AP033_10169	COG1982	Orn Lys Arg decarboxylase major
AP033_10170	COG0531	amino acid
AP033_10171	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AP033_10172	COG1901	pseudouridine methyltransferase
AP033_10174	COG4221	oxidoreductase activity
AP033_10175	COG0840	transmembrane signaling receptor activity
AP033_10177	COG2910	NAD(P)H-binding
AP033_10179	COG1335	isochorismatase
AP033_10182	COG0697	spore germination
AP033_10187	COG0673	inositol 2-dehydrogenase activity
AP033_10188	COG3722	fumarate hydratase activity
AP033_10189	COG0246	Mannitol dehydrogenase
AP033_10190	COG2213	PTS system mannitol-specific
AP033_10190	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AP033_10192	COG0739	heme binding
AP033_10193	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AP033_10194	COG4597	amino acid ABC transporter
AP033_10195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AP033_10197	COG1126	abc transporter atp-binding protein
AP033_10198	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AP033_10200	COG0840	transmembrane signaling receptor activity
AP033_10203	COG0840	transmembrane signaling receptor activity
AP033_10206	COG4580	involved in the transport of maltose and maltodextrins
AP033_10210	COG0363	glucosamine-6-phosphate deaminase activity
AP033_10215	COG2259	Doxx family
AP033_10216	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AP033_10217	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AP033_10219	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AP033_10220	COG3366	ferrous iron transmembrane transporter activity
AP033_10221	COG0700	Nucleoside recognition
AP033_10223	COG0697	spore germination
AP033_10224	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AP033_10225	COG1764	response to oxidative stress
AP033_10226	COG1846	Transcriptional regulator
AP033_10230	COG2207	Transcriptional regulator
AP033_10231	COG1280	lysine exporter protein (LysE YggA)
AP033_10233	COG1902	pentaerythritol trinitrate reductase activity
AP033_10235	COG1132	(ABC) transporter
AP033_10237	COG1902	pentaerythritol trinitrate reductase activity
AP033_10239	COG0583	DNA-binding transcription factor activity
AP033_10240	COG0513	Belongs to the DEAD box helicase family
AP033_10243	COG0840	transmembrane signaling receptor activity
AP033_10245	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AP033_10247	COG1304	FMN binding
AP033_10248	COG1620	l-lactate permease
AP033_10249	COG0583	DNA-binding transcription factor activity
AP033_10253	COG4172	Belongs to the ABC transporter superfamily
AP033_10255	COG1067	ATP-dependent peptidase activity
AP033_10256	COG0840	transmembrane signaling receptor activity
AP033_10258	COG2211	Major facilitator Superfamily
AP033_10260	COG3123	guanosine phosphorylase activity
AP033_10261	COG1741	Belongs to the pirin family
AP033_10263	COG5001	Diguanylate cyclase
AP033_10264	COG0583	DNA-binding transcription factor activity
AP033_10271	COG3706	GGDEF domain
AP033_10272	COG1846	Transcriptional regulator
AP033_10273	COG0784	Response regulator, receiver
AP033_10273	COG0835	chemotaxis
AP033_10274	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AP033_10275	COG2197	response regulator
AP033_10276	COG0393	Putative heavy-metal-binding
AP033_10279	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AP033_10280	COG3842	ATPase activity
AP033_10282	COG1175	transmembrane transport
AP033_10283	COG3833	ABC-type maltose transport systems, permease component
AP033_10286	COG1349	DNA-binding transcription factor activity
AP033_10287	COG3706	GGDEF domain
AP033_10292	COG1278	Cold shock
AP033_10293	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AP033_10294	COG2354	Protein conserved in bacteria
AP033_10295	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AP033_10297	COG3152	Membrane
AP033_10299	COG0418	dihydroorotase activity
AP033_10300	COG0633	Ferredoxin
AP033_10300	COG0633	Ferredoxin
AP033_10300	COG3217	Mosc domain protein beta barrel domain protein
AP033_10300	COG3217	Mosc domain protein beta barrel domain protein
AP033_10307	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AP033_10308	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AP033_10309	COG4558	Periplasmic binding protein
AP033_10310	COG0848	biopolymer transport protein
AP033_10311	COG0811	peptide transport
AP033_10312	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AP033_10314	COG3721	Heme iron utilization protein
AP033_10315	COG0748	coenzyme F420 binding
AP033_10317	COG3835	regulator
AP033_10318	COG2610	gluconate transmembrane transporter activity
AP033_10319	COG1929	Belongs to the glycerate kinase type-1 family
AP033_10324	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AP033_10325	COG0363	glucosamine-6-phosphate deaminase activity
AP033_10326	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AP033_10327	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AP033_10328	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AP033_10332	COG0346	lactoylglutathione lyase activity
AP033_10334	COG2873	o-acetylhomoserine
AP033_10336	COG1063	alcohol dehydrogenase
AP033_10342	COG0582	viral genome integration into host DNA
AP033_10349	COG4626	Terminase
AP033_10349	COG1802	Transcriptional regulator
AP033_10354	COG1278	Cold shock
AP033_10359	COG0640	Transcriptional regulator
AP033_10360	COG0798	PFAM Bile acid sodium symporter
AP033_10383	COG2610	gluconate transmembrane transporter activity
AP033_10384	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AP033_10385	COG3622	Belongs to the hyi family
AP033_10386	COG0235	Class ii aldolase
AP033_10387	COG3395	kinase activity
AP033_10388	COG2084	Dehydrogenase
AP033_10389	COG1349	DNA-binding transcription factor activity
AP033_10391	COG3039	Transposase
AP033_10392	COG3048	D-serine ammonia-lyase activity
AP033_10395	COG1294	oxidase, subunit
AP033_10396	COG1271	oxidase subunit
AP033_10397	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AP033_10398	COG1686	Belongs to the peptidase S11 family
AP033_10401	COG3047	cAMP biosynthetic process
AP033_10402	COG3227	Zinc metalloprotease (Elastase)
AP033_10404	COG2267	carboxylic ester hydrolase activity
AP033_10405	COG2067	long-chain fatty acid transport protein
AP033_10406	COG0366	Alpha amylase catalytic
AP033_10407	COG4989	oxidoreductase activity
AP033_10409	COG1136	(ABC) transporter
AP033_10410	COG1136	(ABC) transporter
AP033_10410	COG0577	efflux transmembrane transporter activity
AP033_10413	COG3275	phosphorelay sensor kinase activity
AP033_10414	COG3279	Response regulator of the LytR AlgR family
AP033_10417	COG3706	GGDEF domain
AP033_10418	COG0531	amino acid
AP033_10423	COG1765	OsmC-like protein
AP033_10424	COG1253	flavin adenine dinucleotide binding
AP033_10425	COG2171	N-acyltransferase activity
AP033_10428	COG0583	DNA-binding transcription factor activity
AP033_10429	COG2264	protein methyltransferase activity
AP033_10432	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AP033_10433	COG3186	Phenylalanine-4-hydroxylase
AP033_10434	COG2154	pterin-4-alpha-carbinolamine dehydratase
AP033_10435	COG0456	acetyltransferase
AP033_10436	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AP033_10437	COG0662	Cupin 2, conserved barrel domain protein
AP033_10438	COG0527	aspartate kinase activity
AP033_10440	COG0459	protein refolding
AP033_10441	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AP033_10442	COG2239	Acts as a magnesium transporter
AP033_10444	COG1166	arginine decarboxylase activity
AP033_10445	COG0010	Belongs to the arginase family
AP033_10447	COG3227	Zinc metalloprotease (Elastase)
AP033_10448	COG3397	chitin binding
AP033_10449	COG3046	protein related to deoxyribodipyrimidine photolyase
AP033_10451	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AP033_10453	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AP033_10454	COG0513	Belongs to the DEAD box helicase family
AP033_10456	COG1368	sulfuric ester hydrolase activity
AP033_10457	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AP033_10460	COG0546	phosphoglycolate phosphatase activity
AP033_10470	COG1328	CTP reductase activity
AP033_10471	COG0602	queuosine metabolic process
AP033_10473	COG0189	ligase activity
AP033_10473	COG4067	protein conserved in archaea
AP033_10474	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AP033_10474	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AP033_10474	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AP033_10475	COG1105	Belongs to the carbohydrate kinase PfkB family
AP033_10476	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AP033_10476	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AP033_10477	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AP033_10477	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AP033_10478	COG1609	Transcriptional regulator
AP033_10479	COG0420	3'-5' exonuclease activity
AP033_10480	COG0419	ATPase involved in DNA repair
AP033_10481	COG0784	Response regulator, receiver
AP033_10481	COG2205	protein histidine kinase activity
AP033_10482	COG0156	8-amino-7-oxononanoate synthase activity
AP033_10484	COG0038	chloride channel
AP033_10485	COG0523	cobalamin synthesis protein
AP033_10487	COG3158	transport of potassium into the cell
AP033_10488	COG1013	pyruvate-flavodoxin oxidoreductase activity
AP033_10488	COG0674	pyruvate-flavodoxin oxidoreductase activity
AP033_10488	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AP033_10488	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AP033_10489	COG2205	protein histidine kinase activity
AP033_10490	COG0745	RESPONSE REGULATOR receiver
AP033_10491	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AP033_10492	COG0586	Pfam SNARE associated Golgi protein
AP033_10494	COG2200	EAL domain
AP033_10496	COG3038	cytochrome b561
AP033_10498	COG2116	formate transmembrane transporter activity
AP033_10499	COG0583	DNA-binding transcription factor activity
AP033_10501	COG3593	DNA synthesis involved in DNA repair
AP033_10502	COG0737	Belongs to the 5'-nucleotidase family
AP033_10504	COG0861	Integral membrane protein TerC family
AP033_10506	COG2824	Alkylphosphonate utilization operon protein PhnA
AP033_10516	COG3706	GGDEF domain
AP033_10519	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AP033_10520	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AP033_10522	COG0745	RESPONSE REGULATOR receiver
AP033_10527	COG0023	Translation Initiation Factor
AP033_10529	COG1181	Belongs to the D-alanine--D-alanine ligase family
AP033_10531	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AP033_10531	COG1042	CoA-binding domain protein
AP033_10531	COG0045	succinate-CoA ligase (ADP-forming) activity
AP033_10532	COG0583	DNA-binding transcription factor activity
AP033_10533	COG4771	TonB-dependent receptor
AP033_10533	COG1629	transport
AP033_10538	COG2050	protein possibly involved in aromatic compounds catabolism
AP033_10542	COG0625	glutathione transferase activity
AP033_10545	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AP033_10546	COG4172	Belongs to the ABC transporter superfamily
AP033_10547	COG4239	(ABC) transporter, permease
AP033_10548	COG4174	ABC transporter (Permease)
AP033_10549	COG4166	transmembrane transport
AP033_10558	COG3842	ATPase activity
AP033_10559	COG1840	ABC-type Fe3 transport system, periplasmic component
AP033_10560	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AP033_10562	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AP033_10563	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AP033_10564	COG1011	Hydrolase
AP033_10566	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AP033_10567	COG1970	mechanosensitive ion channel activity
AP033_10568	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AP033_10569	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AP033_10569	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AP033_10570	COG0302	gtp cyclohydrolase
AP033_10572	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AP033_10574	COG2897	thiosulfate sulfurtransferase activity
AP033_10576	COG2390	Transcriptional regulator
AP033_10577	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AP033_10578	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AP033_10584	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AP033_10589	COG0583	DNA-binding transcription factor activity
AP033_10590	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AP033_10591	COG0778	Nitroreductase
AP033_10596	COG0640	Transcriptional regulator
AP033_10598	COG0446	pyridine nucleotide-disulphide oxidoreductase
AP033_10607	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AP033_10607	COG1263	PTS System
AP033_10609	COG1621	beta-fructofuranosidase activity
AP033_10610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AP033_10611	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AP033_10613	COG2885	chlorophyll binding
AP033_10614	COG0545	Peptidyl-prolyl cis-trans isomerase
AP033_10615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AP033_10616	COG0840	transmembrane signaling receptor activity
AP033_10617	COG3069	C4-dicarboxylate transmembrane transporter activity
AP033_10618	COG1760	l-serine dehydratase
AP033_10623	COG1609	Transcriptional regulator
AP033_10624	COG2197	response regulator
AP033_10625	COG3850	Histidine kinase
AP033_10626	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AP033_10628	COG0243	molybdopterin cofactor binding
AP033_10632	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AP033_10633	COG2197	response regulator
AP033_10634	COG3851	Histidine kinase
AP033_10635	COG2271	Major facilitator Superfamily
AP033_10636	COG1840	ABC-type Fe3 transport system, periplasmic component
AP033_10638	COG3842	ATPase activity
AP033_10639	COG3243	poly(R)-hydroxyalkanoic acid synthase
AP033_10641	COG0183	Belongs to the thiolase family
AP033_10643	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AP033_10644	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AP033_10647	COG3706	GGDEF domain
AP033_10648	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AP033_10650	COG1979	alcohol dehydrogenase
AP033_10653	COG4191	Histidine kinase
AP033_10654	COG1840	ABC-type Fe3 transport system, periplasmic component
AP033_10656	COG2271	Major facilitator Superfamily
AP033_10657	COG0469	pyruvate kinase activity
AP033_10658	COG2205	protein histidine kinase activity
AP033_10658	COG0784	Response regulator, receiver
AP033_10658	COG2198	Histidine kinase
AP033_10659	COG1879	ABC-type sugar transport system periplasmic component
AP033_10660	COG1803	Methylglyoxal synthase
AP033_10661	COG1335	isochorismatase
AP033_10662	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AP033_10665	COG0210	DNA helicase
AP033_10666	COG1289	transmembrane transporter activity
AP033_10672	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AP033_10673	COG4149	molybdate abc transporter
AP033_10674	COG0725	ABC transporter, periplasmic molybdate-binding protein
AP033_10675	COG1492	cobalamin metabolic process
AP033_10676	COG3039	Transposase
AP033_10677	COG3039	Transposase
AP033_10683	COG5002	protein histidine kinase activity
AP033_10683	COG0784	Response regulator, receiver
AP033_10684	COG1879	ABC-type sugar transport system periplasmic component
AP033_10686	COG2827	Endonuclease containing a URI domain
AP033_10693	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AP033_10694	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AP033_10695	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
AP033_10696	COG0247	lactate metabolic process
AP033_10697	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AP033_10698	COG3118	belongs to the thioredoxin family
AP033_10703	COG4160	amino acid transport
AP033_10704	COG4215	(ABC) transporter
AP033_10705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AP033_10706	COG1126	abc transporter atp-binding protein
AP033_10708	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AP033_10710	COG0494	nUDIX hydrolase
AP033_10711	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AP033_10713	COG1309	transcriptional regulator
AP033_10714	COG0513	Belongs to the DEAD box helicase family
AP033_10715	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
AP033_10717	COG0814	amino acid
AP033_10718	COG0840	transmembrane signaling receptor activity
AP033_10719	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AP033_10720	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AP033_10722	COG1984	allophanate hydrolase subunit 2
AP033_10725	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AP033_10726	COG4181	ATPase activity
AP033_10728	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AP033_10729	COG1716	ATPase activity
AP033_10729	COG5001	Diguanylate cyclase
AP033_10731	COG0484	heat shock protein binding
AP033_10737	COG0346	lactoylglutathione lyase activity
AP033_10747	COG1943	Transposase
AP033_10759	COG3039	Transposase
AP033_10766	COG0346	lactoylglutathione lyase activity
AP033_10769	COG0110	maltose O-acetyltransferase activity
AP033_10770	COG3039	Transposase
AP033_10775	COG4977	sequence-specific DNA binding
AP033_10776	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AP033_10786	COG3040	lipid binding
AP033_10806	COG3039	Transposase
AP033_10808	COG0346	lactoylglutathione lyase activity
AP033_10814	COG0384	phenazine biosynthesis protein PhzF
AP033_10815	COG3093	addiction module antidote protein HigA
AP033_10816	COG3549	Plasmid maintenance system killer
AP033_10831	COG3039	Transposase
AP033_10835	COG4977	sequence-specific DNA binding
AP033_10841	COG3039	Transposase
AP033_10842	COG1619	proteins homologs of microcin C7 resistance protein MccF
AP033_10845	COG0384	phenazine biosynthesis protein PhzF
AP033_10855	COG0346	lactoylglutathione lyase activity
AP033_10864	COG0346	lactoylglutathione lyase activity
AP033_10890	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AP033_10891	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AP033_10893	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AP033_10922	COG3772	lysozyme
AP033_10941	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AP033_10943	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AP033_10944	COG0509	glycine decarboxylation via glycine cleavage system
AP033_10945	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AP033_10945	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AP033_10946	COG1943	Transposase
AP033_10951	COG1686	Belongs to the peptidase S11 family
AP033_10954	COG2814	Major facilitator Superfamily
AP033_10957	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AP033_10962	COG5000	phosphorelay sensor kinase activity
AP033_10962	COG5002	protein histidine kinase activity
AP033_10963	COG0745	RESPONSE REGULATOR receiver
AP033_10967	COG0366	Alpha amylase catalytic
AP033_10968	COG3038	cytochrome b561
AP033_10974	COG0561	phosphatase activity
AP033_10975	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AP033_10976	COG3623	hexulose-6-phosphate isomerase
AP033_10978	COG0745	RESPONSE REGULATOR receiver
AP033_10982	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AP033_10986	COG4604	ABC transporter, ATP-binding protein
AP033_10987	COG4605	iron ion homeostasis
AP033_10988	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AP033_10992	COG4412	M6 family metalloprotease domain protein
AP033_10992	COG3291	Pkd domain containing protein
AP033_10993	COG5380	lipid catabolic process
AP033_10994	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AP033_10995	COG0840	transmembrane signaling receptor activity
AP033_10997	COG3240	lipase activity
AP033_10998	COG3706	GGDEF domain
AP033_10999	COG2814	Major facilitator Superfamily
AP033_11000	COG1757	Na H antiporter
AP033_11002	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AP033_11002	COG4191	Histidine kinase
AP033_11003	COG3437	response regulator, receiver
AP033_11003	COG0784	Response regulator, receiver
AP033_11004	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AP033_11005	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AP033_11006	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AP033_11007	COG0513	Belongs to the DEAD box helicase family
AP033_11009	COG0516	GMP reductase activity
AP033_11011	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AP033_11013	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AP033_11014	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AP033_11014	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AP033_11019	COG3036	rescue of stalled ribosome
AP033_11020	COG1278	Cold shock
AP033_11021	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AP033_11021	COG1017	nitric oxide dioxygenase activity
AP033_11022	COG3604	Transcriptional regulator
AP033_11024	COG2195	Cleaves the N-terminal amino acid of tripeptides
AP033_11025	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AP033_11028	COG0840	transmembrane signaling receptor activity
AP033_11029	COG0714	Associated with various cellular activities
AP033_11033	COG2304	oxidoreductase activity
AP033_11036	COG1278	Cold shock
AP033_11037	COG5001	Diguanylate cyclase
AP033_11037	COG5002	protein histidine kinase activity
AP033_11039	COG3530	Putative quorum-sensing-regulated virulence factor
AP033_11040	COG3033	Beta-eliminating lyase
AP033_11041	COG0814	amino acid
AP033_11042	COG0589	response to stress
AP033_11044	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AP033_11044	COG2111	Na H antiporter
AP033_11048	COG2212	antiporter activity
AP033_11049	COG1320	monovalent cation:proton antiporter activity
AP033_11050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AP033_11050	COG1017	nitric oxide dioxygenase activity
AP033_11051	COG0242	peptide deformylase activity
AP033_11053	COG0579	oxidoreductase
AP033_20001	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AP033_20002	COG1194	a g-specific adenine glycosylase
AP033_20003	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AP033_20004	COG2066	Belongs to the glutaminase family
AP033_20005	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AP033_20006	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AP033_20008	COG1872	DUF167
AP033_20009	COG0762	integral membrane protein
AP033_20010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AP033_20011	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AP033_20015	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AP033_20016	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AP033_20017	COG1678	Uncharacterized ACR, COG1678
AP033_20018	COG0189	ligase activity
AP033_20019	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AP033_20020	COG2356	endonuclease I
AP033_20021	COG3091	SprT-like family
AP033_20022	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AP033_20023	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AP033_20024	COG0583	DNA-binding transcription factor activity
AP033_20025	COG4771	TonB-dependent receptor
AP033_20026	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AP033_20027	COG0126	phosphoglycerate kinase activity
AP033_20028	COG0191	fructose-bisphosphate aldolase activity
AP033_20029	COG0668	transmembrane transport
AP033_20030	COG1279	arginine transmembrane transporter activity
AP033_20031	COG0583	DNA-binding transcription factor activity
AP033_20034	COG0469	pyruvate kinase activity
AP033_20035	COG1349	DNA-binding transcription factor activity
AP033_20036	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AP033_20037	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AP033_20040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AP033_20041	COG0358	DNA primase activity
AP033_20042	COG1610	YqeY-like protein
AP033_20043	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AP033_20044	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AP033_20046	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AP033_20047	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AP033_20048	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AP033_20049	COG1968	undecaprenyl-diphosphatase activity
AP033_20050	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AP033_20051	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AP033_20052	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AP033_20053	COG0585	pseudouridine synthase activity
AP033_20054	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AP033_20055	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AP033_20056	COG4942	peptidase
AP033_20056	COG1388	LysM domain
AP033_20057	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AP033_20058	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AP033_20062	COG4208	sulfate ABC transporter
AP033_20063	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AP033_20065	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AP033_20066	COG2137	regulation of response to DNA damage stimulus
AP033_20067	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AP033_20068	COG0527	aspartate kinase activity
AP033_20069	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AP033_20078	COG3630	sodium ion export across plasma membrane
AP033_20079	COG0511	ligase activity, forming carbon-carbon bonds
AP033_20079	COG5016	pyruvate
AP033_20080	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AP033_20082	COG1238	metal cluster binding
AP033_20083	COG0612	Peptidase, M16
AP033_20084	COG2918	glutathione biosynthetic process
AP033_20085	COG1854	S-ribosylhomocysteine lyase activity
AP033_20086	COG4536	flavin adenine dinucleotide binding
AP033_20087	COG4137	Cytochrome C assembly protein
AP033_20089	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AP033_20090	COG0228	four-way junction DNA binding
AP033_20091	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AP033_20092	COG0336	Belongs to the RNA methyltransferase TrmD family
AP033_20093	COG0335	large ribosomal subunit rRNA binding
AP033_20094	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AP033_20095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AP033_20097	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AP033_20098	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AP033_20099	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AP033_20100	COG0723	plastoquinol--plastocyanin reductase activity
AP033_20101	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AP033_20102	COG2857	Cytochrome c1
AP033_20103	COG0625	glutathione transferase activity
AP033_20104	COG2969	positive regulation of protein catabolic process
AP033_20105	COG2823	Periplasmic or secreted lipoprotein
AP033_20106	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AP033_20107	COG0792	nuclease activity
AP033_20108	COG3107	peptidoglycan biosynthetic process
AP033_20109	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AP033_20112	COG0288	reversible hydration of carbon dioxide
AP033_20113	COG0659	secondary active sulfate transmembrane transporter activity
AP033_20114	COG1131	(ABC) transporter
AP033_20115	COG0842	Transport permease protein
AP033_20116	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AP033_20117	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AP033_20118	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AP033_20120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AP033_20121	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AP033_20122	COG1489	DNA binding
AP033_20124	COG1643	Atp-dependent helicase
AP033_20125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AP033_20126	COG1752	Esterase of the alpha-beta hydrolase superfamily
AP033_20127	COG1049	propionate catabolic process, 2-methylcitrate cycle
AP033_20128	COG3112	Uncharacterised protein family (UPF0231)
AP033_20129	COG0347	Belongs to the P(II) protein family
AP033_20130	COG0004	ammonium transporteR
AP033_20131	COG1840	ABC-type Fe3 transport system, periplasmic component
AP033_20133	COG3842	ATPase activity
AP033_20137	COG2971	BadF BadG BcrA BcrD
AP033_20139	COG4608	Belongs to the ABC transporter superfamily
AP033_20140	COG0444	Belongs to the ABC transporter superfamily
AP033_20141	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AP033_20142	COG0601	transmembrane transport
AP033_20143	COG0747	negative chemotaxis
AP033_20145	COG2813	Specifically methylates the guanine in position
AP033_20146	COG0628	permease
AP033_20148	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AP033_20149	COG0316	Belongs to the HesB IscA family
AP033_20152	COG0739	heme binding
AP033_20153	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AP033_20154	COG2027	D-alanyl-D-alanine carboxypeptidase
AP033_20155	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AP033_20156	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AP033_20157	COG1534	Rna-binding protein
AP033_20158	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AP033_20159	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AP033_20160	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AP033_20161	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AP033_20163	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AP033_20166	COG0779	Required for maturation of 30S ribosomal subunits
AP033_20167	COG0195	Participates in both transcription termination and antitermination
AP033_20168	COG0195	Participates in both transcription termination and antitermination
AP033_20169	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AP033_20170	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AP033_20171	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AP033_20172	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AP033_20173	COG1185	polyribonucleotide nucleotidyltransferase activity
AP033_20174	COG4785	May be involved in cell division
AP033_20181	COG3153	acetyltransferase
AP033_20185	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AP033_20186	COG0513	Belongs to the DEAD box helicase family
AP033_20187	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AP033_20189	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AP033_20190	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AP033_20191	COG2204	response regulator
AP033_20193	COG0667	Aldo Keto reductase
AP033_20194	COG3066	DNA modification
AP033_20195	COG0494	nUDIX hydrolase
AP033_20196	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
AP033_20197	COG0730	response to heat
AP033_20198	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AP033_20199	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AP033_20200	COG1283	sodium-dependent phosphate transmembrane transporter activity
AP033_20201	COG0583	DNA-binding transcription factor activity
AP033_20202	COG0640	Transcriptional regulator
AP033_20203	COG0268	Binds directly to 16S ribosomal RNA
AP033_20204	COG0728	peptidoglycan biosynthetic process
AP033_20205	COG0196	riboflavin kinase activity
AP033_20206	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AP033_20207	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AP033_20208	COG1047	Peptidyl-prolyl cis-trans
AP033_20209	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AP033_20210	COG1966	Carbon starvation protein
AP033_20213	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AP033_20214	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AP033_20215	COG1472	Belongs to the glycosyl hydrolase 3 family
AP033_20216	COG3279	Response regulator of the LytR AlgR family
AP033_20217	COG3275	phosphorelay sensor kinase activity
AP033_20218	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AP033_20219	COG1605	Chorismate mutase
AP033_20219	COG0287	Prephenate dehydrogenase
AP033_20221	COG0488	(ABC) transporter
AP033_20223	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
AP033_20224	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AP033_20225	COG5001	Diguanylate cyclase
AP033_20226	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AP033_20227	COG0077	Prephenate dehydratase
AP033_20227	COG1605	Chorismate mutase
AP033_20228	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AP033_20229	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AP033_20230	COG0564	pseudouridine synthase activity
AP033_20232	COG0542	response to heat
AP033_20240	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AP033_20242	COG2974	May be involved in recombination
AP033_20243	COG0745	RESPONSE REGULATOR receiver
AP033_20244	COG5002	protein histidine kinase activity
AP033_20246	COG0248	Ppx GppA phosphatase
AP033_20247	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AP033_20249	COG0581	inorganic phosphate transmembrane transporter activity
AP033_20250	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AP033_20253	COG3142	Participates in the control of copper homeostasis
AP033_20254	COG0450	alkyl hydroperoxide reductase
AP033_20255	COG0583	DNA-binding transcription factor activity
AP033_20256	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AP033_20258	COG0517	IMP dehydrogenase activity
AP033_20259	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AP033_20260	COG0343	queuine tRNA-ribosyltransferase activity
AP033_20261	COG1862	Preprotein translocase
AP033_20262	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AP033_20263	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AP033_20264	COG0483	inositol monophosphate 1-phosphatase activity
AP033_20266	COG1959	2 iron, 2 sulfur cluster binding
AP033_20267	COG1104	cysteine desulfurase activity
AP033_20268	COG0822	iron-sulfur transferase activity
AP033_20270	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AP033_20272	COG0633	Ferredoxin
AP033_20273	COG2975	iron-sulfur cluster assembly
AP033_20274	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AP033_20275	COG0105	UTP biosynthetic process
AP033_20278	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AP033_20279	COG0124	histidyl-tRNA synthetase
AP033_20280	COG2976	Protein conserved in bacteria
AP033_20281	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AP033_20282	COG1160	GTP binding
AP033_20285	COG1570	exodeoxyribonuclease VII activity
AP033_20286	COG0517	IMP dehydrogenase activity
AP033_20286	COG0516	GMP reductase activity
AP033_20287	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AP033_20287	COG0519	Catalyzes the synthesis of GMP from XMP
AP033_20289	COG1584	GPR1 FUN34 yaaH family protein
AP033_20290	COG1535	isochorismatase
AP033_20290	COG3433	isochorismatase activity
AP033_20291	COG1021	2,3-dihydroxybenzoate-AMP ligase
AP033_20292	COG1169	isochorismate synthase
AP033_20293	COG1028	Short-chain dehydrogenase reductase Sdr
AP033_20295	COG4592	Periplasmic binding protein
AP033_20296	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AP033_20297	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AP033_20298	COG1120	ATPase activity
AP033_20300	COG0583	DNA-binding transcription factor activity
AP033_20301	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AP033_20302	COG1115	amino acid carrier protein
AP033_20303	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AP033_20304	COG0583	DNA-binding transcription factor activity
AP033_20307	COG4565	transcriptional regulatory protein
AP033_20309	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AP033_20310	COG0511	ligase activity, forming carbon-carbon bonds
AP033_20310	COG5016	pyruvate
AP033_20311	COG3630	sodium ion export across plasma membrane
AP033_20313	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
AP033_20314	COG3052	prosthetic group binding
AP033_20315	COG2301	Belongs to the HpcH HpaI aldolase family
AP033_20316	COG3051	citrate lyase alpha subunit
AP033_20317	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
AP033_20318	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AP033_20320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AP033_20321	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AP033_20322	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AP033_20331	COG3039	Transposase
AP033_20343	COG1012	belongs to the aldehyde dehydrogenase family
AP033_20347	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AP033_20348	COG0840	transmembrane signaling receptor activity
AP033_20349	COG3710	Transcriptional regulator
AP033_20354	COG4796	Type ii and iii secretion system protein
AP033_20358	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AP033_20359	COG1459	type II secretion system
AP033_20362	COG2207	Transcriptional regulator
AP033_20363	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AP033_20368	COG0739	heme binding
AP033_20370	COG3064	Membrane
AP033_20371	COG0582	viral genome integration into host DNA
AP033_20372	COG0582	viral genome integration into host DNA
AP033_20374	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AP033_20375	COG2867	negative regulation of translational initiation
AP033_20376	COG2914	Belongs to the UPF0125 (RnfH) family
AP033_20377	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AP033_20378	COG0497	DNA recombination
AP033_20379	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AP033_20380	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AP033_20381	COG0443	Heat shock 70 kDa protein
AP033_20382	COG0484	heat shock protein binding
AP033_20388	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AP033_20389	COG0590	tRNA wobble adenosine to inosine editing
AP033_20391	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AP033_20392	COG0047	phosphoribosylformylglycinamidine synthase activity
AP033_20392	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AP033_20393	COG1943	Transposase
AP033_20397	COG0442	prolyl-tRNA aminoacylation
AP033_20398	COG1720	tRNA m6t6A37 methyltransferase activity
AP033_20399	COG0254	rRNA binding
AP033_20400	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AP033_20401	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AP033_20402	COG1671	Belongs to the UPF0178 family
AP033_20404	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AP033_20407	COG3098	single-species biofilm formation
AP033_20408	COG0564	pseudouridine synthase activity
AP033_20409	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AP033_20410	COG0142	geranyltranstransferase activity
AP033_20411	COG1722	exodeoxyribonuclease VII activity
AP033_20412	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AP033_20414	COG0301	tRNA thio-modification
AP033_20414	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AP033_20415	COG0583	DNA-binding transcription factor activity
AP033_20416	COG2363	Small membrane protein
AP033_20417	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AP033_20418	COG1611	Belongs to the LOG family
AP033_20419	COG3706	GGDEF domain
AP033_20421	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AP033_20421	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AP033_20423	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
AP033_20424	COG1464	Belongs to the NlpA lipoprotein family
AP033_20425	COG2011	ABC-type metal ion transport system permease component
AP033_20426	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AP033_20427	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AP033_20428	COG1609	Transcriptional regulator
AP033_20429	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AP033_20429	COG1263	PTS System
AP033_20430	COG0366	Alpha amylase catalytic
AP033_20436	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AP033_20437	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AP033_20438	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AP033_20439	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AP033_20440	COG0110	maltose O-acetyltransferase activity
AP033_20444	COG1045	serine acetyltransferase
AP033_20446	COG0438	transferase activity, transferring glycosyl groups
AP033_20448	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AP033_20454	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AP033_20456	COG1596	polysaccharide export
AP033_20461	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AP033_20463	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AP033_20464	COG0321	lipoyl(octanoyl) transferase activity
AP033_20465	COG2921	Belongs to the UPF0250 family
AP033_20466	COG1686	Belongs to the peptidase S11 family
AP033_20467	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AP033_20468	COG0772	Belongs to the SEDS family
AP033_20469	COG0768	penicillin binding
AP033_20470	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AP033_20471	COG0799	negative regulation of ribosome biogenesis
AP033_20472	COG1466	dna polymerase III delta subunit
AP033_20473	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
AP033_20474	COG0495	leucyl-tRNA aminoacylation
AP033_20475	COG2888	peptidyl-tyrosine sulfation
AP033_20476	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AP033_20477	COG4535	Mg2 and Co2 transporter CorC
AP033_20478	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AP033_20479	COG1702	phosphate starvation-inducible protein PhoH
AP033_20480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AP033_20481	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AP033_20482	COG2190	(PTS) system
AP033_20484	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AP033_20485	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AP033_20486	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AP033_20487	COG3115	cell septum assembly
AP033_20488	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AP033_20491	COG0789	Transcriptional regulator
AP033_20492	COG1585	Membrane protein implicated in regulation of membrane protease activity
AP033_20493	COG0330	HflC and HflK could
AP033_20494	COG3118	belongs to the thioredoxin family
AP033_20495	COG3039	Transposase
AP033_20496	COG0300	oxidoreductase activity
AP033_20497	COG1090	epimerase
AP033_20498	COG0622	Phosphoesterase
AP033_20501	COG3710	Transcriptional regulator
AP033_20502	COG0326	Molecular chaperone. Has ATPase activity
AP033_20503	COG0563	adenylate kinase activity
AP033_20504	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AP033_20507	COG0367	asparagine synthase
AP033_20508	COG4651	solute:proton antiporter activity
AP033_20508	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AP033_20509	COG1846	Transcriptional regulator
AP033_20509	COG1940	carbohydrate kinase activity
AP033_20510	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AP033_20511	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AP033_20511	COG1263	PTS System
AP033_20511	COG2190	(PTS) system
AP033_20512	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AP033_20514	COG0101	tRNA pseudouridine synthase activity
AP033_20515	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AP033_20516	COG0285	dihydrofolate synthase activity
AP033_20517	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AP033_20518	COG1286	toxin biosynthetic process
AP033_20519	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AP033_20520	COG2056	Na+-H+ antiporter family
AP033_20521	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AP033_20524	COG0346	lactoylglutathione lyase activity
AP033_20525	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AP033_20526	COG4660	Part of a membrane complex involved in electron transport
AP033_20527	COG4659	FMN binding
AP033_20528	COG4658	electron transport chain
AP033_20529	COG4656	Part of a membrane complex involved in electron transport
AP033_20530	COG2878	Part of a membrane complex involved in electron transport
AP033_20531	COG4657	Part of a membrane complex involved in electron transport
AP033_20533	COG0556	nucleotide-excision repair
AP033_20534	COG2204	response regulator
AP033_20535	COG2198	Histidine kinase
AP033_20536	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AP033_20537	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AP033_20538	COG0521	Mo-molybdopterin cofactor biosynthetic process
AP033_20539	COG0315	cyclic pyranopterin monophosphate synthase activity
AP033_20540	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AP033_20541	COG0314	molybdopterin synthase activity
AP033_20542	COG2199	diguanylate cyclase activity
AP033_20543	COG4109	DRTGG domain
AP033_20545	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AP033_20546	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AP033_20548	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AP033_20548	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AP033_20549	COG0489	protein tyrosine kinase activity
AP033_20550	COG0572	uridine kinase
AP033_20551	COG2982	Protein involved in outer membrane biogenesis
AP033_20552	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AP033_20553	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AP033_20555	COG2067	long-chain fatty acid transport protein
AP033_20558	COG0183	Belongs to the thiolase family
AP033_20559	COG1024	Enoyl-CoA hydratase
AP033_20559	COG1250	3-hydroxyacyl-CoA dehydrogenase
AP033_20560	COG0778	Nitroreductase
AP033_20561	COG0583	DNA-binding transcription factor activity
AP033_20562	COG0745	RESPONSE REGULATOR receiver
AP033_20564	COG2832	Protein of unknown function (DUF454)
AP033_20565	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AP033_20566	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AP033_20567	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AP033_20568	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AP033_20571	COG1028	Short-chain dehydrogenase reductase Sdr
AP033_20572	COG0616	signal peptide processing
AP033_20574	COG1522	sequence-specific DNA binding
AP033_20575	COG1946	Acyl-CoA thioesterase
AP033_20579	COG3706	GGDEF domain
AP033_20580	COG0640	Transcriptional regulator
AP033_20581	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AP033_20586	COG1881	PFAM PEBP family protein
AP033_20587	COG1881	PFAM PEBP family protein
AP033_20590	COG0009	L-threonylcarbamoyladenylate synthase
AP033_20593	COG2201	protein-glutamate methylesterase activity
AP033_20595	COG5002	protein histidine kinase activity
AP033_20596	COG4191	Histidine kinase
AP033_20597	COG3300	MHYT domain
AP033_20597	COG5001	Diguanylate cyclase
AP033_20598	COG2204	response regulator
AP033_20602	COG0601	transmembrane transport
AP033_20603	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AP033_20604	COG0444	Belongs to the ABC transporter superfamily
AP033_20605	COG4608	Belongs to the ABC transporter superfamily
AP033_20606	COG0435	Glutathione S-transferase
AP033_20607	COG0280	phosphate acetyltransferase
AP033_20607	COG0857	belongs to the CobB CobQ family
AP033_20608	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AP033_20609	COG3092	negative regulation of chromosome organization
AP033_20610	COG4628	conserved protein (DUF2132)
AP033_20612	COG4120	Belongs to the binding-protein-dependent transport system permease family
AP033_20614	COG2203	Gaf domain
AP033_20614	COG2199	diguanylate cyclase activity
AP033_20615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AP033_20617	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AP033_20618	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AP033_20619	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AP033_20620	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AP033_20621	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AP033_20622	COG0156	8-amino-7-oxononanoate synthase activity
AP033_20623	COG2226	methyltransferase
AP033_20624	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AP033_20626	COG0501	Belongs to the peptidase M48B family
AP033_20628	COG0300	oxidoreductase activity
AP033_20631	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AP033_20633	COG2268	Band 7 protein
AP033_20635	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AP033_20636	COG2915	High frequency lysogenization protein hflD homolog
AP033_20637	COG0482	sulfurtransferase activity
AP033_20638	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AP033_20639	COG2916	Histone family protein nucleoid-structuring protein H-NS
AP033_20640	COG1757	Na H antiporter
AP033_20641	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AP033_20642	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AP033_20643	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AP033_20644	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AP033_20644	COG0131	Imidazoleglycerol-phosphate dehydratase
AP033_20645	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AP033_20646	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AP033_20647	COG0107	imidazoleglycerol-phosphate synthase activity
AP033_20648	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AP033_20648	COG0140	phosphoribosyl-ATP diphosphatase activity
AP033_20649	COG1187	pseudouridine synthase activity
AP033_20651	COG1278	Cold shock
AP033_20652	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AP033_20653	COG0542	response to heat
AP033_20655	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AP033_20656	COG1012	belongs to the aldehyde dehydrogenase family
AP033_20656	COG1454	alcohol dehydrogenase
AP033_20657	COG1737	Transcriptional regulator
AP033_20658	COG0076	glutamate decarboxylase activity
AP033_20660	COG2431	L-lysine efflux transmembrane transporter activity
AP033_20662	COG3070	regulator of competence-specific genes
AP033_20665	COG3852	Histidine kinase
AP033_20667	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AP033_20670	COG0189	ligase activity
AP033_20670	COG4067	protein conserved in archaea
AP033_20671	COG0500	methyltransferase
AP033_20672	COG4106	trans-aconitate 2-methyltransferase activity
AP033_20673	COG1801	Protein of unknown function DUF72
AP033_20674	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AP033_20675	COG1435	thymidine kinase activity
AP033_20677	COG0159	tryptophan synthase activity
AP033_20678	COG0133	tryptophan synthase activity
AP033_20679	COG0134	indole-3-glycerol-phosphate synthase activity
AP033_20679	COG0135	phosphoribosylanthranilate isomerase activity
AP033_20680	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AP033_20681	COG0512	Glutamine amidotransferase of anthranilate synthase
AP033_20682	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AP033_20683	COG0613	PHP domain protein
AP033_20684	COG0009	L-threonylcarbamoyladenylate synthase
AP033_20685	COG1187	pseudouridine synthase activity
AP033_20686	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AP033_20687	COG4988	ABC transporter
AP033_20688	COG0492	ferredoxin-NADP+ reductase activity
AP033_20691	COG3706	GGDEF domain
AP033_20692	COG2949	membrane
AP033_20694	COG0281	malic enzyme
AP033_20696	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AP033_20700	COG2885	chlorophyll binding
AP033_20703	COG0277	FAD linked oxidase domain protein
AP033_20703	COG0247	lactate metabolic process
AP033_20707	COG2986	histidine ammonia-lyase
AP033_20708	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AP033_20709	COG0010	Belongs to the arginase family
AP033_20710	COG1228	amidohydrolase
AP033_20714	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AP033_20716	COG5001	Diguanylate cyclase
AP033_20717	COG0417	DNA replication proofreading
AP033_20718	COG2197	response regulator
AP033_20719	COG0322	excinuclease ABC activity
AP033_20725	COG0745	RESPONSE REGULATOR receiver
AP033_20725	COG3706	GGDEF domain
AP033_20727	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AP033_20728	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AP033_20728	COG0072	phenylalanine-tRNA ligase activity
AP033_20729	COG0776	regulation of translation
AP033_20732	COG0500	methyltransferase
AP033_20733	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AP033_20735	COG0295	cytidine deaminase activity
AP033_20736	COG1346	cytolysis
AP033_20738	COG2925	Exonuclease
AP033_20740	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AP033_20741	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AP033_20742	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AP033_20745	COG2988	succinylglutamate desuccinylase activity
AP033_20746	COG4139	cobalamin transport
AP033_20747	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
AP033_20756	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AP033_20757	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AP033_20758	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AP033_20762	COG2814	Major facilitator Superfamily
AP033_20764	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AP033_20770	COG3108	Peptidase M15
AP033_20771	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AP033_20774	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AP033_20779	COG1846	Transcriptional regulator
AP033_20780	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AP033_20781	COG0726	polysaccharide deacetylase
AP033_20782	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AP033_20784	COG1447	Phosphotransferase system cellobiose-specific component IIA
AP033_20785	COG1486	melibiose metabolic process
AP033_20786	COG3394	polysaccharide catabolic process
AP033_20787	COG1609	Transcriptional regulator
AP033_20788	COG2943	transferase activity, transferring hexosyl groups
AP033_20789	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AP033_20790	COG0840	transmembrane signaling receptor activity
AP033_20793	COG1448	Aminotransferase
AP033_20794	COG2770	Histidine kinase
AP033_20794	COG3437	response regulator, receiver
AP033_20795	COG0352	thiamine-phosphate diphosphorylase activity
AP033_20795	COG0351	phosphomethylpyrimidine kinase
AP033_20796	COG0017	Asparaginyl-tRNA synthetase
AP033_20798	COG0720	synthase
AP033_20799	COG1760	l-serine dehydratase
AP033_20800	COG0814	amino acid
AP033_20801	COG0494	nUDIX hydrolase
AP033_20802	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AP033_20805	COG3106	COG3106 Predicted ATPase
AP033_20806	COG3768	UPF0283 membrane protein
AP033_20807	COG3283	Transcriptional regulator of aromatic amino acids metabolism
AP033_20808	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AP033_20811	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AP033_20813	COG0471	metal ion transport
AP033_20814	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AP033_20814	COG4191	Histidine kinase
AP033_20816	COG2990	Protein conserved in bacteria
AP033_20817	COG3713	MltA-interacting MipA family protein
AP033_20818	COG2205	protein histidine kinase activity
AP033_20819	COG0745	RESPONSE REGULATOR receiver
AP033_20824	COG1129	ABC transporter
AP033_20826	COG3039	Transposase
AP033_20831	COG2186	Transcriptional regulator
AP033_20832	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AP033_20833	COG0372	Belongs to the citrate synthase family
AP033_20839	COG2195	Cleaves the N-terminal amino acid of tripeptides
AP033_20841	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AP033_20843	COG0625	glutathione transferase activity
AP033_20844	COG3437	response regulator, receiver
AP033_20845	COG4999	Histidine kinase
AP033_20845	COG2205	protein histidine kinase activity
AP033_20845	COG3437	response regulator, receiver
AP033_20845	COG3850	Histidine kinase
AP033_20847	COG3706	GGDEF domain
AP033_20848	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AP033_20849	COG1254	Belongs to the acylphosphatase family
AP033_20850	COG2920	part of a sulfur-relay system
AP033_20851	COG0670	Belongs to the BI1 family
AP033_20852	COG1126	abc transporter atp-binding protein
AP033_20853	COG0765	amino acid transport
AP033_20854	COG4597	amino acid ABC transporter
AP033_20855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AP033_20857	COG0561	phosphatase activity
AP033_20859	COG0602	queuosine metabolic process
AP033_20860	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AP033_20866	COG3706	GGDEF domain
AP033_20867	COG0443	Heat shock 70 kDa protein
AP033_20868	COG0443	Heat shock 70 kDa protein
AP033_20875	COG1643	Atp-dependent helicase
AP033_20877	COG0443	Heat shock 70 kDa protein
AP033_20878	COG0095	Lipoate-protein ligase
AP033_20879	COG0583	DNA-binding transcription factor activity
AP033_20880	COG0477	Major facilitator Superfamily
AP033_20881	COG0415	Belongs to the DNA photolyase family
AP033_20882	COG2076	Multidrug Resistance protein
AP033_20886	COG0643	Histidine kinase
AP033_20886	COG2198	Histidine kinase
AP033_20888	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AP033_20890	COG2201	protein-glutamate methylesterase activity
AP033_20891	COG0835	chemotaxis
AP033_20892	COG3290	protein histidine kinase activity
AP033_20892	COG0840	transmembrane signaling receptor activity
AP033_20893	COG0840	transmembrane signaling receptor activity
AP033_20895	COG0513	Belongs to the DEAD box helicase family
AP033_20898	COG1566	PFAM secretion protein HlyD family protein
AP033_20899	COG2814	Major facilitator Superfamily
AP033_20901	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AP033_20903	COG3501	Rhs element vgr protein
AP033_20907	COG1280	lysine exporter protein (LysE YggA)
AP033_20908	COG1115	amino acid carrier protein
AP033_20911	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AP033_20912	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AP033_20913	COG1177	transmembrane transport
AP033_20914	COG1176	ABC-type spermidine putrescine transport system, permease component I
AP033_20915	COG3842	ATPase activity
AP033_20919	COG0037	tRNA processing
AP033_20920	COG0589	response to stress
AP033_20921	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AP033_20924	COG2217	Heavy metal translocating P-type atpase
AP033_20926	COG2010	Cytochrome c
AP033_20929	COG3278	Belongs to the heme-copper respiratory oxidase family
AP033_20932	COG0784	Response regulator, receiver
AP033_20932	COG2205	protein histidine kinase activity
AP033_20937	COG2994	toxin metabolic process
AP033_20938	COG1073	alpha beta
AP033_20938	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AP033_20938	COG3064	Membrane
AP033_20941	COG3120	sequence-specific DNA binding
AP033_20942	COG1067	ATP-dependent peptidase activity
AP033_20943	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AP033_20948	COG0116	Belongs to the methyltransferase superfamily
AP033_20948	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AP033_20951	COG0167	dihydroorotate dehydrogenase activity
AP033_20953	COG0308	aminopeptidase N
AP033_20956	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AP033_20957	COG1956	GAF domain-containing protein
AP033_20958	COG1132	(ABC) transporter
AP033_20959	COG2995	paraquat-inducible protein a
AP033_20960	COG3008	intermembrane lipid transfer
AP033_20961	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AP033_20961	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AP033_20962	COG2996	Protein conserved in bacteria
AP033_20965	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AP033_20967	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AP033_20970	COG0437	4 iron, 4 sulfur cluster binding
AP033_20971	COG3383	formate dehydrogenase (NAD+) activity
AP033_20971	COG0243	molybdopterin cofactor binding
AP033_20977	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AP033_20979	COG0488	(ABC) transporter
AP033_20980	COG3852	Histidine kinase
AP033_20981	COG2204	response regulator
AP033_20983	COG4662	Binding-protein-dependent transport system inner membrane component
AP033_20984	COG3842	ATPase activity
AP033_20985	COG0746	molybdenum cofactor guanylyltransferase activity
AP033_20988	COG1940	carbohydrate kinase activity
AP033_20991	COG0840	transmembrane signaling receptor activity
AP033_20992	COG0791	NLP P60 protein
AP033_20996	COG0534	Mate efflux family protein
AP033_20998	COG1793	dna ligase
AP033_21001	COG0848	biopolymer transport protein
AP033_21002	COG0811	peptide transport
AP033_21003	COG0811	peptide transport
AP033_21006	COG1175	transmembrane transport
AP033_21007	COG0395	ABC-type sugar transport system, permease component
AP033_21008	COG3842	ATPase activity
AP033_21009	COG1349	DNA-binding transcription factor activity
AP033_21010	COG0584	glycerophosphoryl diester phosphodiesterase
AP033_21011	COG2731	YhcH YjgK YiaL family protein
AP033_21012	COG0251	oxidation-reduction process
AP033_21013	COG1609	Transcriptional regulator
AP033_21014	COG2723	6-phospho-beta-galactosidase activity
AP033_21015	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AP033_21016	COG0583	DNA-binding transcription factor activity
AP033_21020	COG0577	efflux transmembrane transporter activity
AP033_21020	COG1136	(ABC) transporter
AP033_21021	COG0577	efflux transmembrane transporter activity
AP033_21021	COG1136	(ABC) transporter
AP033_21022	COG4591	ABC-type transport system involved in lipoprotein release permease component
AP033_21022	COG1136	(ABC) transporter
AP033_21023	COG1294	oxidase, subunit
AP033_21024	COG1271	oxidase subunit
AP033_21032	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AP033_21034	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AP033_21038	COG0753	catalase activity
AP033_21041	COG3527	Alpha-acetolactate decarboxylase
AP033_21044	COG2200	EAL domain
AP033_21044	COG2199	diguanylate cyclase activity
AP033_21045	COG3706	GGDEF domain
AP033_21046	COG2017	converts alpha-aldose to the beta-anomer
AP033_21047	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AP033_21048	COG1085	galactose-1-phosphate uridylyltransferase
AP033_21053	COG3706	GGDEF domain
AP033_21053	COG0745	RESPONSE REGULATOR receiver
AP033_21056	COG0784	Response regulator, receiver
AP033_21056	COG0835	chemotaxis
AP033_21058	COG4565	transcriptional regulatory protein
AP033_21059	COG3290	protein histidine kinase activity
AP033_21062	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AP033_21066	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AP033_21067	COG3063	Type IV pilus biogenesis stability protein PilW
AP033_21070	COG1451	nucleotide metabolic process
AP033_21072	COG0583	DNA-binding transcription factor activity
AP033_21076	COG1538	Outer membrane efflux protein
AP033_21078	COG0019	diaminopimelate decarboxylase activity
AP033_21079	COG1748	Saccharopine dehydrogenase
AP033_21080	COG0076	glutamate decarboxylase activity
AP033_21082	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AP033_21085	COG4181	ATPase activity
AP033_21086	COG0534	Mate efflux family protein
AP033_21087	COG0702	epimerase
AP033_21089	COG2814	Major facilitator Superfamily
AP033_21090	COG1187	pseudouridine synthase activity
AP033_21091	COG1061	Type III restriction enzyme res subunit
AP033_21094	COG5002	protein histidine kinase activity
AP033_21095	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AP033_21096	COG5001	Diguanylate cyclase
AP033_21096	COG4251	negative regulation of phosphorylation
AP033_21096	COG3706	GGDEF domain
AP033_21096	COG2203	Gaf domain
AP033_21098	COG0840	transmembrane signaling receptor activity
AP033_21104	COG4934	collagen metabolic process
AP033_21108	COG2239	Acts as a magnesium transporter
AP033_21110	COG0814	amino acid
AP033_21111	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AP033_21112	COG1131	(ABC) transporter
AP033_21113	COG0842	Transport permease protein
AP033_21115	COG3313	Fe-S protein
AP033_21117	COG4134	Bacterial extracellular solute-binding protein
AP033_21118	COG4135	transport system, permease component
AP033_21119	COG4136	ATPase activity
AP033_21120	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AP033_21121	COG0564	pseudouridine synthase activity
AP033_21122	COG0733	neurotransmitter:sodium symporter activity
AP033_21124	COG0626	cystathionine gamma-synthase activity
AP033_21125	COG2818	Glycosylase
AP033_21128	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AP033_21131	COG1842	Phage shock protein A
AP033_21132	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AP033_21134	COG4168	peptide transport system, permease
AP033_21135	COG4171	peptide transport system, permease
AP033_21137	COG4172	Belongs to the ABC transporter superfamily
AP033_21140	COG1227	inorganic diphosphatase activity
AP033_21145	COG0243	molybdopterin cofactor binding
AP033_21146	COG3005	denitrification pathway
AP033_21147	COG4459	periplasmic nitrate reductase
AP033_21148	COG2116	formate transmembrane transporter activity
AP033_21150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AP033_21151	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AP033_21153	COG2917	probably involved in intracellular septation
AP033_21154	COG1607	acyl-coa hydrolase
AP033_21155	COG2350	Protein conserved in bacteria
AP033_21157	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AP033_21158	COG0583	DNA-binding transcription factor activity
AP033_21161	COG0612	Peptidase, M16
AP033_21162	COG5001	Diguanylate cyclase
AP033_21163	COG1032	radical SAM domain protein
AP033_21164	COG1280	lysine exporter protein (LysE YggA)
AP033_21166	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AP033_21167	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AP033_21168	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
AP033_21169	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AP033_21170	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AP033_21171	COG0745	RESPONSE REGULATOR receiver
AP033_21172	COG3381	protein complex oligomerization
AP033_21173	COG1609	Transcriptional regulator
AP033_21174	COG3070	regulator of competence-specific genes
AP033_21178	COG0297	glycogen (starch) synthase activity
AP033_21179	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AP033_21180	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AP033_21182	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AP033_21183	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AP033_21184	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AP033_21185	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AP033_21186	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AP033_21187	COG1960	acyl-CoA dehydrogenase activity
AP033_21191	COG1012	belongs to the aldehyde dehydrogenase family
AP033_21192	COG1309	transcriptional regulator
AP033_21196	COG0668	transmembrane transport
AP033_21197	COG2995	paraquat-inducible protein a
AP033_21198	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AP033_21198	COG3008	intermembrane lipid transfer
AP033_21200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AP033_21203	COG0582	viral genome integration into host DNA
AP033_21204	COG0582	viral genome integration into host DNA
AP033_21205	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AP033_21211	COG0415	Belongs to the DNA photolyase family
AP033_21213	COG4628	conserved protein (DUF2132)
AP033_21214	COG3284	Transcriptional regulator
AP033_21215	COG1012	belongs to the aldehyde dehydrogenase family
AP033_21217	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AP033_21218	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AP033_21219	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AP033_21221	COG2207	Transcriptional regulator
AP033_21222	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AP033_21222	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AP033_21222	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AP033_21223	COG1482	cell wall glycoprotein biosynthetic process
AP033_21225	COG5002	protein histidine kinase activity
AP033_21225	COG0784	Response regulator, receiver
AP033_21227	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AP033_21229	COG2885	chlorophyll binding
AP033_21230	COG0823	Involved in the tonB-independent uptake of proteins
AP033_21233	COG0811	peptide transport
AP033_21234	COG0824	Thioesterase
AP033_21235	COG3790	cyd operon protein YbgE
AP033_21236	COG4890	Cyd operon protein YbgT
AP033_21237	COG1294	oxidase, subunit
AP033_21238	COG1271	oxidase subunit
AP033_21240	COG2255	four-way junction helicase activity
AP033_21241	COG0632	four-way junction helicase activity
AP033_21242	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AP033_21243	COG0215	cysteine-tRNA ligase activity
AP033_21244	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AP033_21245	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AP033_21246	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AP033_21248	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AP033_21249	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AP033_21250	COG1199	ATP-dependent helicase activity
AP033_21251	COG0730	response to heat
AP033_21252	COG3923	Primosomal replication protein n
AP033_21254	COG0840	transmembrane signaling receptor activity
AP033_21255	COG0708	Exodeoxyribonuclease III
AP033_21256	COG4160	amino acid transport
AP033_21257	COG4215	(ABC) transporter
AP033_21262	COG1882	Formate acetyltransferase
AP033_21264	COG0840	transmembrane signaling receptor activity
AP033_21265	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AP033_21267	COG3013	Belongs to the UPF0304 family
AP033_21268	COG2766	serine protein kinase
AP033_21269	COG2718	Belongs to the UPF0229 family
AP033_21270	COG2719	SpoVR family
AP033_21271	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AP033_21273	COG1663	tetraacyldisaccharide 4'-kinase activity
AP033_21274	COG1132	(ABC) transporter
AP033_21275	COG0658	competence protein
AP033_21275	COG2333	competence protein COMEC
AP033_21277	COG4591	ABC-type transport system involved in lipoprotein release permease component
AP033_21278	COG1136	(ABC) transporter
AP033_21279	COG4591	ABC-type transport system involved in lipoprotein release permease component
AP033_21281	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AP033_21285	COG1252	NADH dehydrogenase
AP033_21291	COG0537	adenosine 5'-monophosphoramidase activity
AP033_21294	COG2186	Transcriptional regulator
AP033_21295	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AP033_21296	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AP033_21297	COG1674	ftsk spoiiie
AP033_21299	COG0686	Belongs to the AlaDH PNT family
AP033_21301	COG0583	DNA-binding transcription factor activity
AP033_21304	COG0284	orotidine-5'-phosphate decarboxylase activity
AP033_21305	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AP033_21306	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AP033_21307	COG0776	regulation of translation
AP033_21308	COG0539	negative regulation of cytoplasmic translation
AP033_21309	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AP033_21310	COG1555	photosystem II stabilization
AP033_21311	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AP033_21312	COG0776	regulation of translation
AP033_21313	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AP033_21314	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AP033_21316	COG0544	peptidyl-prolyl cis-trans isomerase activity
AP033_21317	COG4191	Histidine kinase
AP033_21319	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AP033_21320	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AP033_21321	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AP033_21322	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AP033_21325	COG3300	MHYT domain
AP033_21325	COG5001	Diguanylate cyclase
AP033_21327	COG4589	Belongs to the CDS family
AP033_21334	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AP033_21336	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AP033_21339	COG0243	molybdopterin cofactor binding
AP033_21340	COG3005	denitrification pathway
AP033_21341	COG3469	chitinase activity
AP033_21341	COG3325	Belongs to the glycosyl hydrolase 18 family
AP033_21342	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AP033_21344	COG2951	lytic endotransglycosylase activity
AP033_21345	COG3100	YcgL domain-containing protein
AP033_21346	COG0850	regulation of cytokinetic process
AP033_21347	COG2894	cell division
AP033_21348	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AP033_21349	COG3015	lipoprotein NlpE involved in copper resistance
AP033_21354	COG0477	Major facilitator Superfamily
AP033_21355	COG0840	transmembrane signaling receptor activity
AP033_21356	COG1396	sequence-specific DNA binding
AP033_21357	COG3135	benzoate transporter
AP033_21359	COG1441	menaquinone biosynthetic process
AP033_21361	COG0596	Alpha beta hydrolase
AP033_21362	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AP033_21363	COG1169	isochorismate synthase
AP033_21364	COG0436	Aminotransferase
AP033_21365	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AP033_21366	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AP033_21370	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AP033_21371	COG0318	PFAM AMP-dependent synthetase and ligase
AP033_21372	COG0596	Alpha beta hydrolase
AP033_21375	COG1214	PFAM Peptidase M22, glycoprotease
AP033_21376	COG1199	ATP-dependent helicase activity
AP033_21378	COG0788	formyltetrahydrofolate deformylase activity
AP033_21379	COG1902	pentaerythritol trinitrate reductase activity
AP033_21379	COG0446	pyridine nucleotide-disulphide oxidoreductase
AP033_21380	COG0616	signal peptide processing
AP033_21381	COG0252	asparaginase activity
AP033_21382	COG3139	Protein of unknown function (DUF1315)
AP033_21384	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AP033_21385	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AP033_21386	COG0676	glucose-6-phosphate 1-epimerase activity
AP033_21388	COG2226	methyltransferase
AP033_21391	COG0784	Response regulator, receiver
AP033_21391	COG0835	chemotaxis
AP033_21392	COG1940	carbohydrate kinase activity
AP033_21394	COG4667	esterase of the alpha-beta hydrolase superfamily
AP033_21397	COG0733	neurotransmitter:sodium symporter activity
AP033_21399	COG1263	PTS System
AP033_21399	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AP033_21400	COG0084	hydrolase, TatD family'
AP033_21402	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AP033_21403	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AP033_21404	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AP033_21405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AP033_21406	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AP033_21407	COG1028	Short-chain dehydrogenase reductase Sdr
AP033_21408	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AP033_21409	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AP033_21410	COG0416	fatty acid biosynthetic process
AP033_21411	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AP033_21412	COG1399	metal-binding, possibly nucleic acid-binding protein
AP033_21413	COG0424	maF-like protein
AP033_21414	COG0564	pseudouridine synthase activity
AP033_21415	COG1530	ribonuclease E activity
AP033_21416	COG0659	secondary active sulfate transmembrane transporter activity
AP033_21418	COG1012	belongs to the aldehyde dehydrogenase family
AP033_21418	COG1454	alcohol dehydrogenase
AP033_21419	COG2095	MarC family integral membrane protein
AP033_21420	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AP033_21421	COG1757	Na H antiporter
AP033_21423	COG3081	Nucleoid-associated protein
AP033_21425	COG3083	sulfuric ester hydrolase activity
AP033_21440	COG4974	Belongs to the 'phage' integrase family
AP033_21442	COG3617	BRO family, N-terminal domain
AP033_21468	COG3039	Transposase
AP033_21476	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AP033_21481	COG0123	including yeast histone deacetylase and acetoin utilization protein
AP033_21482	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AP033_21483	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AP033_21487	COG2853	Lipoprotein
AP033_21489	COG4235	cytochrome complex assembly
AP033_21489	COG3088	subunit of a heme lyase
AP033_21490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AP033_21491	COG1138	Cytochrome C-type biogenesis protein
AP033_21492	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AP033_21494	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AP033_21495	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AP033_21496	COG4133	protoheme IX ABC transporter activity
AP033_21498	COG0835	chemotaxis
AP033_21500	COG1192	Involved in chromosome partitioning
AP033_21501	COG2201	protein-glutamate methylesterase activity
AP033_21502	COG0643	Histidine kinase
AP033_21502	COG2198	Histidine kinase
AP033_21503	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AP033_21506	COG0455	bacterial-type flagellum organization
AP033_21509	COG2062	phosphohistidine phosphatase, SixA
AP033_21510	COG1025	Belongs to the peptidase M16 family
AP033_21512	COG0018	arginyl-trna synthetase
AP033_21516	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AP033_21517	COG1918	ferrous iron import across plasma membrane
AP033_21518	COG4977	sequence-specific DNA binding
AP033_21519	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AP033_21520	COG1121	(ABC) transporter
AP033_21521	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AP033_21523	COG0045	succinate-CoA ligase (ADP-forming) activity
AP033_21524	COG0508	dehydrogenase complex catalyzes the overall conversion of
AP033_21525	COG0567	Dehydrogenase, E1 component
AP033_21527	COG1053	succinate dehydrogenase
AP033_21528	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AP033_21529	COG2009	succinate dehydrogenase
AP033_21530	COG0372	Belongs to the citrate synthase family
AP033_21531	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AP033_21533	COG0033	Phosphoglucomutase
AP033_21534	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AP033_21535	COG0596	Alpha beta hydrolase
AP033_21538	COG1346	cytolysis
AP033_21540	COG0583	DNA-binding transcription factor activity
AP033_21542	COG0735	belongs to the Fur family
AP033_21543	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AP033_21544	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AP033_21545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AP033_21546	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AP033_21546	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AP033_21547	COG0431	NADPH-dependent FMN reductase
AP033_21549	COG3101	peptidyl-lysine hydroxylation
AP033_21550	COG2860	membrane
AP033_21551	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AP033_21552	COG2890	protein-(glutamine-N5) methyltransferase activity
AP033_21554	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AP033_21555	COG1684	flagellar biosynthetic protein fliR
AP033_21556	COG1987	bacterial-type flagellum assembly
AP033_21561	COG1580	Controls the rotational direction of flagella during chemotaxis
AP033_21565	COG1317	bacterial-type flagellum organization
AP033_21566	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AP033_21568	COG1677	Flagellar hook-basal body complex protein FliE
AP033_21569	COG2204	response regulator
AP033_21570	COG4191	Histidine kinase
AP033_21571	COG2204	response regulator
AP033_21572	COG1516	flagellar protein fliS
AP033_21574	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AP033_21575	COG1334	flagellar protein FlaG
AP033_21576	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AP033_21577	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AP033_21578	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AP033_21579	COG2837	iron assimilation
AP033_21583	COG1393	Belongs to the ArsC family
AP033_21584	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AP033_21585	COG1876	peptidase activity
AP033_21587	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AP033_21588	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AP033_21590	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AP033_21594	COG4783	chaperone-mediated protein folding
AP033_21595	COG1393	Belongs to the ArsC family
AP033_21599	COG2233	PERMEase
AP033_21600	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AP033_21601	COG0737	Belongs to the 5'-nucleotidase family
AP033_21602	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AP033_21603	COG2912	Transglutaminase-like superfamily
AP033_21604	COG3094	Invasion gene expression up-regulator, SirB
AP033_21605	COG2890	protein-(glutamine-N5) methyltransferase activity
AP033_21606	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AP033_21607	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AP033_21608	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AP033_21609	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AP033_21610	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AP033_21611	COG0193	aminoacyl-tRNA hydrolase activity
AP033_21612	COG0012	GTP binding
AP033_21629	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AP033_21630	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AP033_21633	COG1705	Flagellar rod assembly protein muramidase FlgJ
AP033_21633	COG3951	Flagellar rod assembly protein muramidase FlgJ
AP033_21634	COG1706	bacterial-type flagellum-dependent cell motility
AP033_21635	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AP033_21636	COG4786	Flagellar basal body rod
AP033_21637	COG4787	bacterial-type flagellum-dependent cell motility
AP033_21638	COG1749	Flagellar hook protein flgE
AP033_21639	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AP033_21640	COG1558	bacterial-type flagellum-dependent cell motility
AP033_21641	COG1815	bacterial-type flagellum-dependent cell motility
AP033_21642	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AP033_21643	COG0835	chemotaxis
AP033_21643	COG0784	Response regulator, receiver
AP033_21650	COG2226	methyltransferase
AP033_21650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AP033_21650	COG3433	isochorismatase activity
AP033_21651	COG2375	cellular response to nickel ion
AP033_21652	COG4774	siderophore transport
AP033_21652	COG1629	transport
AP033_21655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AP033_21656	COG2217	Heavy metal translocating P-type atpase
AP033_21656	COG2608	mercury ion transmembrane transporter activity
AP033_21659	COG3735	TraB family
AP033_21662	COG2840	Smr protein MutS2
AP033_21663	COG1187	pseudouridine synthase activity
AP033_21664	COG3706	GGDEF domain
AP033_21666	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AP033_21667	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AP033_21668	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AP033_21669	COG0121	glutamine amidotransferase
AP033_21670	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AP033_21671	COG1960	acyl-CoA dehydrogenase activity
AP033_21673	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AP033_21674	COG0328	RNA-DNA hybrid ribonuclease activity
AP033_21675	COG2226	methyltransferase
AP033_21676	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AP033_21677	COG1388	LysM domain
AP033_21677	COG0741	lytic transglycosylase activity
AP033_21678	COG3942	CHAP domain
AP033_21678	COG1388	LysM domain
AP033_21680	COG0347	Belongs to the P(II) protein family
AP033_21681	COG3479	Phenolic acid decarboxylase
AP033_21683	COG0037	tRNA processing
AP033_21684	COG0825	malonyl-CoA metabolic process
AP033_21685	COG0587	DNA-directed DNA polymerase activity
AP033_21686	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AP033_21687	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AP033_21688	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AP033_21689	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AP033_21690	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AP033_21691	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
AP033_21693	COG0750	zinc metalloprotease
AP033_21694	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AP033_21695	COG0575	Belongs to the CDS family
AP033_21696	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AP033_21697	COG0233	cytoplasmic translational termination
AP033_21698	COG0528	UMP kinase activity
AP033_21699	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AP033_21700	COG0052	Belongs to the universal ribosomal protein uS2 family
AP033_21701	COG0024	Methionine aminopeptidase
AP033_21702	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AP033_21704	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AP033_21705	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AP033_21706	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AP033_21707	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AP033_21710	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AP033_21710	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AP033_21711	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AP033_21712	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AP033_21713	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AP033_21716	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AP033_21717	COG2252	PERMEase
AP033_21718	COG2195	Cleaves the N-terminal amino acid of tripeptides
AP033_21719	COG0189	ligase activity
AP033_21719	COG4067	protein conserved in archaea
AP033_21720	COG0189	ligase activity
AP033_21722	COG0733	neurotransmitter:sodium symporter activity
AP033_21723	COG3706	GGDEF domain
AP033_21725	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AP033_21727	COG1477	protein flavinylation
AP033_21728	COG2871	sodium ion transport
AP033_21729	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AP033_21730	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AP033_21731	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AP033_21732	COG1805	sodium ion transport
AP033_21733	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AP033_21734	COG0271	Belongs to the BolA IbaG family
AP033_21735	COG2813	Specifically methylates the guanine in position
AP033_21737	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AP033_21738	COG2211	Major facilitator Superfamily
AP033_21740	COG1595	DNA-templated transcription, initiation
AP033_21742	COG3248	Nucleoside-binding outer membrane protein
AP033_21743	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AP033_21744	COG0693	protein deglycase activity
AP033_21745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AP033_21746	COG2166	iron-sulfur cluster assembly
AP033_21747	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AP033_21748	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AP033_21750	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AP033_21750	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AP033_21752	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AP033_21753	COG1074	ATP-dependent DNA helicase activity
AP033_21754	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AP033_21757	COG3141	response to X-ray
AP033_21758	COG2171	N-acyltransferase activity
AP033_21760	COG0456	acetyltransferase
AP033_21761	COG0569	domain protein
AP033_21761	COG0189	ligase activity
AP033_21764	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AP033_21765	COG1609	Transcriptional regulator
AP033_21766	COG3250	beta-galactosidase activity
AP033_21769	COG1022	Amp-dependent synthetase and ligase
AP033_21770	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AP033_21771	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AP033_21773	COG0560	Phosphoserine phosphatase
AP033_21775	COG0813	purine-nucleoside phosphorylase activity
AP033_21776	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AP033_21777	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AP033_21778	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AP033_21779	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AP033_21780	COG0084	hydrolase, TatD family'
AP033_21783	COG1115	amino acid carrier protein
AP033_21786	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AP033_21787	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AP033_21788	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
AP033_21789	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AP033_21790	COG0083	homoserine kinase activity
AP033_21793	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AP033_21795	COG0745	RESPONSE REGULATOR receiver
AP033_21796	COG5002	protein histidine kinase activity
AP033_21796	COG0784	Response regulator, receiver
AP033_21796	COG2198	Histidine kinase
AP033_21797	COG2203	Gaf domain
AP033_21797	COG4251	negative regulation of phosphorylation
AP033_21797	COG5001	Diguanylate cyclase
AP033_21797	COG3706	GGDEF domain
AP033_21798	COG1242	4 iron, 4 sulfur cluster binding
AP033_21799	COG0070	glutamate synthase
AP033_21799	COG0069	glutamate synthase activity
AP033_21799	COG0067	glutamate synthase
AP033_21801	COG0067	glutamate synthase
AP033_21801	COG0069	glutamate synthase activity
AP033_21801	COG0070	glutamate synthase
AP033_21802	COG0493	'glutamate synthase
AP033_21804	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AP033_21806	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AP033_21807	COG2860	membrane
AP033_21808	COG0583	DNA-binding transcription factor activity
AP033_21809	COG0730	response to heat
AP033_21811	COG4172	Belongs to the ABC transporter superfamily
AP033_21815	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AP033_21816	COG0505	Belongs to the CarA family
AP033_21817	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AP033_21818	COG0494	nUDIX hydrolase
AP033_21819	COG0653	protein targeting
AP033_21821	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AP033_21822	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AP033_21823	COG0849	cell division
AP033_21824	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AP033_21825	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AP033_21826	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AP033_21827	COG0772	Belongs to the SEDS family
AP033_21828	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AP033_21829	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AP033_21830	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AP033_21831	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AP033_21832	COG0768	penicillin binding
AP033_21833	COG3116	cell division
AP033_21834	COG0275	rRNA processing
AP033_21835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AP033_21836	COG0508	dehydrogenase complex catalyzes the overall conversion of
AP033_21837	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AP033_21838	COG2186	Transcriptional regulator
AP033_21839	COG0737	Belongs to the 5'-nucleotidase family
AP033_21840	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AP033_21841	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AP033_21842	COG4974	Belongs to the 'phage' integrase family
AP033_21843	COG0716	FMN binding
AP033_21848	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AP033_21849	COG1459	type II secretion system
AP033_21851	COG0237	dephospho-CoA kinase activity
AP033_21852	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AP033_21853	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AP033_21854	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AP033_21855	COG0187	DNA topoisomerase II activity
AP033_21856	COG3150	esterase
AP033_21858	COG3151	Protein conserved in bacteria
AP033_21859	COG0494	nUDIX hydrolase
AP033_21860	COG1538	Outer membrane efflux protein
AP033_21861	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AP033_21861	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AP033_21862	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AP033_21863	COG0840	transmembrane signaling receptor activity
AP033_21865	COG3025	triphosphatase activity
AP033_21866	COG1392	Phosphate transport regulator
AP033_21867	COG0306	phosphate transporter
AP033_21868	COG4991	sh3 domain protein
AP033_21870	COG3409	Peptidoglycan-binding domain 1 protein
AP033_21870	COG3267	Type II secretory pathway component ExeA
AP033_21871	COG0617	tRNA 3'-terminal CCA addition
AP033_21872	COG0148	phosphopyruvate hydratase activity
AP033_21873	COG0504	CTP synthase activity
AP033_21874	COG3956	TIGRFAM MazG family protein
AP033_21875	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AP033_21876	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AP033_21881	COG0736	holo-[acyl-carrier-protein] synthase activity
AP033_21882	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AP033_21883	COG1381	Involved in DNA repair and RecF pathway recombination
AP033_21884	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AP033_21885	COG0571	ribonuclease III activity
AP033_21886	COG0681	Belongs to the peptidase S26 family
AP033_21887	COG0481	GTPase activity
AP033_21888	COG3086	response to oxidative stress
AP033_21889	COG3026	antisigma factor binding
AP033_21891	COG1595	DNA-templated transcription, initiation
AP033_21892	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AP033_21894	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AP033_21895	COG0354	folic acid binding
AP033_21897	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AP033_21898	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AP033_21900	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AP033_21901	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AP033_21902	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AP033_21903	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AP033_21904	COG0440	acetolactate synthase activity
AP033_21905	COG0028	Belongs to the TPP enzyme family
AP033_21906	COG1022	Amp-dependent synthetase and ligase
AP033_21907	COG0583	DNA-binding transcription factor activity
AP033_21911	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AP033_21912	COG0473	3-isopropylmalate dehydrogenase activity
AP033_21913	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AP033_21914	COG0066	3-isopropylmalate dehydratase activity
AP033_21923	COG3437	response regulator, receiver
AP033_21926	COG0795	lipopolysaccharide-transporting ATPase activity
AP033_21927	COG0795	lipopolysaccharide-transporting ATPase activity
AP033_21928	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AP033_21929	COG2927	DNA polymerase III (CHI subunit)
AP033_21930	COG0525	valine-tRNA ligase activity
AP033_21931	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AP033_21932	COG0564	pseudouridine synthase activity
AP033_21933	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AP033_21934	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AP033_21935	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AP033_21936	COG0540	Belongs to the ATCase OTCase family
AP033_21937	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AP033_21938	COG0251	oxidation-reduction process
AP033_21939	COG0204	Acyl-transferase
AP033_21940	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AP033_21941	COG5007	Belongs to the BolA IbaG family
AP033_21943	COG2854	intermembrane phospholipid transfer
AP033_21944	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AP033_21945	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AP033_21946	COG1127	ABC transporter
AP033_21948	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AP033_21948	COG0517	IMP dehydrogenase activity
AP033_21951	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AP033_21952	COG1137	ATPase activity
AP033_21954	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AP033_21955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AP033_21957	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AP033_21958	COG2239	Acts as a magnesium transporter
AP033_21959	COG0312	modulator of DNA gyrase
AP033_21960	COG3028	Belongs to the UPF0307 family
AP033_21961	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AP033_21962	COG1178	ABC-type Fe3 transport system permease component
AP033_21963	COG4143	(ABC) transporter
AP033_21964	COG0163	prenyltransferase activity
AP033_21965	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AP033_21966	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AP033_21967	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AP033_21968	COG2105	PFAM AIG2 family protein
AP033_21970	COG0729	surface antigen
AP033_21971	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AP033_21972	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AP033_21975	COG1136	(ABC) transporter
AP033_21979	COG0529	Catalyzes the synthesis of activated sulfate
AP033_21980	COG2895	sulfate adenylyltransferase (ATP) activity
AP033_21981	COG0175	sulfate reduction
AP033_21982	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AP033_21982	COG1648	precorrin-2 dehydrogenase activity
AP033_21983	COG0737	Belongs to the 5'-nucleotidase family
AP033_21985	COG0513	Belongs to the DEAD box helicase family
AP033_21986	COG2153	protein acetylation
AP033_21987	COG0697	spore germination
AP033_21988	COG3061	Opacity-associated protein A
AP033_21988	COG3266	domain, Protein
AP033_21989	COG0545	Peptidyl-prolyl cis-trans isomerase
AP033_21990	COG1943	Transposase
AP033_21992	COG0203	ribosomal protein L17
AP033_21993	COG0202	RNA polymerase activity
AP033_21994	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AP033_21995	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AP033_21996	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AP033_21998	COG0201	protein transport
AP033_21999	COG0200	Binds to the 23S rRNA
AP033_22000	COG1841	ribosomal large subunit assembly
AP033_22001	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AP033_22002	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AP033_22003	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AP033_22004	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AP033_22005	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AP033_22006	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AP033_22007	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AP033_22008	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AP033_22009	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AP033_22010	COG0255	Belongs to the universal ribosomal protein uL29 family
AP033_22011	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AP033_22012	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AP033_22013	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AP033_22014	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AP033_22015	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AP033_22016	COG0089	rRNA binding
AP033_22017	COG0088	Forms part of the polypeptide exit tunnel
AP033_22018	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AP033_22019	COG0051	transcription antitermination factor activity, RNA binding
AP033_22020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AP033_22021	COG0557	exoribonuclease II activity
AP033_22022	COG3083	sulfuric ester hydrolase activity
AP033_22023	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AP033_22024	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AP033_22026	COG1047	Peptidyl-prolyl cis-trans
AP033_22030	COG2249	NAD(P)H dehydrogenase (quinone) activity
AP033_22031	COG0488	(ABC) transporter
AP033_22033	COG0429	hydrolase of the alpha beta-hydrolase fold
AP033_22035	COG3954	Phosphoribulokinase
AP033_22036	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AP033_22038	COG1012	belongs to the aldehyde dehydrogenase family
AP033_22040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AP033_22042	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AP033_22045	COG0180	Tryptophanyl-tRNA synthetase
AP033_22046	COG0546	phosphoglycolate phosphatase activity
AP033_22047	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AP033_22048	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AP033_22050	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AP033_22051	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AP033_22057	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AP033_22059	COG0678	peroxiredoxin activity
AP033_22059	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AP033_22060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AP033_22062	COG0165	Argininosuccinate lyase
AP033_22063	COG0137	argininosuccinate synthase activity
AP033_22064	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AP033_22065	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AP033_22066	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AP033_22067	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AP033_22069	COG1045	serine acetyltransferase
AP033_22070	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AP033_22071	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AP033_22072	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AP033_22073	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AP033_22074	COG1053	succinate dehydrogenase
AP033_22075	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AP033_22076	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AP033_22077	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AP033_22078	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AP033_22079	COG1509	lysine 2,3-aminomutase activity
AP033_22081	COG0459	protein refolding
AP033_22082	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AP033_22087	COG0149	triose-phosphate isomerase activity
AP033_22089	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AP033_22090	COG1575	Belongs to the MenA family. Type 1 subfamily
AP033_22091	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AP033_22092	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AP033_22093	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AP033_22094	COG1609	Transcriptional regulator
AP033_22095	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AP033_22096	COG0254	rRNA binding
AP033_22097	COG0281	malic enzyme
AP033_22098	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
AP033_22099	COG0626	cystathionine gamma-synthase activity
AP033_22100	COG0527	aspartate kinase activity
AP033_22100	COG0460	homoserine dehydrogenase
AP033_22101	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AP033_22102	COG3074	FtsZ-dependent cytokinesis
AP033_22103	COG1494	fructose-1,6-bisphosphatase
AP033_22104	COG0205	6-phosphofructokinase activity
AP033_22105	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AP033_22107	COG0745	RESPONSE REGULATOR receiver
AP033_22108	COG2205	protein histidine kinase activity
AP033_22110	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AP033_22111	COG3030	protein affecting phage T7 exclusion by the F plasmid
AP033_22112	COG3706	GGDEF domain
AP033_22113	COG1027	Aspartate ammonia-lyase
AP033_22114	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AP033_22116	COG4232	protein-disulfide reductase activity
AP033_22118	COG3263	regulation of cellular component size
AP033_22120	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AP033_22121	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AP033_22122	COG0194	GDP metabolic process
AP033_22123	COG1758	RNA polymerase activity
AP033_22124	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AP033_22125	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AP033_22126	COG2233	PERMEase
AP033_22128	COG0745	RESPONSE REGULATOR receiver
AP033_22129	COG2199	diguanylate cyclase activity
AP033_22130	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AP033_22131	COG2183	response to ionizing radiation
AP033_22133	COG0596	Alpha beta hydrolase
AP033_22134	COG1040	competence protein
AP033_22135	COG0316	Belongs to the HesB IscA family
AP033_22135	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AP033_22136	COG0494	nUDIX hydrolase
AP033_22137	COG1218	3'(2'),5'-bisphosphate nucleotidase
AP033_22139	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AP033_22140	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AP033_22141	COG3156	type II secretion system protein K
AP033_22142	COG4795	General secretion pathway protein
AP033_22143	COG2165	general secretion pathway protein
AP033_22144	COG2165	general secretion pathway protein
AP033_22145	COG2165	general secretion pathway protein
AP033_22146	COG1459	type II secretion system
AP033_22147	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AP033_22149	COG3031	protein transport across the cell outer membrane
AP033_22150	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AP033_22151	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AP033_22152	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AP033_22154	COG0456	acetyltransferase
AP033_22155	COG1490	D-aminoacyl-tRNA deacylase activity
AP033_22160	COG0174	glutamine synthetase
AP033_22162	COG3852	Histidine kinase
AP033_22164	COG3300	MHYT domain
AP033_22164	COG5001	Diguanylate cyclase
AP033_22165	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AP033_22179	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AP033_22180	COG1404	Belongs to the peptidase S8 family
AP033_22181	COG4206	TonB-dependent receptor
AP033_22182	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AP033_22185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AP033_22186	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AP033_22187	COG2177	Part of the ABC transporter FtsEX involved in
AP033_22188	COG2884	Cell division ATP-binding protein ftsE
AP033_22189	COG0552	protein localization to endoplasmic reticulum
AP033_22190	COG0742	ribosomal rna small subunit methyltransferase
AP033_22195	COG0783	Belongs to the Dps family
AP033_22196	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AP033_22197	COG1280	lysine exporter protein (LysE YggA)
AP033_22198	COG2267	carboxylic ester hydrolase activity
AP033_22199	COG0561	phosphatase activity
AP033_22202	COG3287	FIST C domain
AP033_22202	COG2199	diguanylate cyclase activity
AP033_22202	COG2200	EAL domain
AP033_22203	COG1011	Hydrolase
AP033_22204	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AP033_22206	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AP033_22207	COG0019	diaminopimelate decarboxylase activity
AP033_22208	COG1965	Belongs to the frataxin family
AP033_22209	COG3072	Adenylate cyclase
AP033_22210	COG0181	hydroxymethylbilane synthase activity
AP033_22211	COG1587	Uroporphyrinogen-III synthase
AP033_22212	COG2959	enzyme of heme biosynthesis
AP033_22213	COG3071	HemY protein
AP033_22214	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AP033_22216	COG3078	GTPase activator activity
AP033_22219	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AP033_22220	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AP033_22220	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AP033_22223	COG0084	hydrolase, TatD family'
AP033_22224	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AP033_22226	COG0840	transmembrane signaling receptor activity
AP033_22227	COG1580	Controls the rotational direction of flagella during chemotaxis
AP033_22228	COG3161	chorismate lyase activity
AP033_22229	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AP033_22230	COG2937	Belongs to the GPAT DAPAT family
AP033_22231	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AP033_22233	COG0534	Mate efflux family protein
AP033_22234	COG0805	protein transport
AP033_22235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AP033_22236	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AP033_22237	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AP033_22239	COG2226	methyltransferase
AP033_22240	COG1322	Protein conserved in bacteria
AP033_22242	COG2081	HI0933 family
AP033_22244	COG1528	Iron-storage protein
AP033_22245	COG0589	response to stress
AP033_22246	COG0697	spore germination
AP033_22248	COG0742	ribosomal rna small subunit methyltransferase
AP033_22249	COG5002	protein histidine kinase activity
AP033_22249	COG5001	Diguanylate cyclase
AP033_22250	COG1522	sequence-specific DNA binding
AP033_22254	COG0006	proline dipeptidase activity
AP033_22254	COG0006	proline dipeptidase activity
AP033_22255	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AP033_22256	COG2022	thiamine diphosphate biosynthetic process
AP033_22257	COG2104	thiamine diphosphate biosynthetic process
AP033_22258	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AP033_22260	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AP033_22261	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AP033_22268	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AP033_22270	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AP033_22271	COG0408	coproporphyrinogen oxidase activity
AP033_22272	COG0009	L-threonylcarbamoyladenylate synthase
AP033_22273	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AP033_22274	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AP033_22275	COG0551	DNA topoisomerase type I activity
AP033_22276	COG2922	Belongs to the Smg family
AP033_22277	COG0758	DNA mediated transformation
AP033_22278	COG1652	LysM domain
AP033_22279	COG0242	peptide deformylase activity
AP033_22280	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AP033_22281	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AP033_22281	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AP033_22282	COG0569	domain protein
AP033_22283	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AP033_22285	COG1272	protein, Hemolysin III
AP033_22286	COG4326	sporulation control protein
AP033_22287	COG3084	Protein conserved in bacteria
AP033_22289	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AP033_22290	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AP033_22291	COG0204	Acyl-transferase
AP033_22292	COG0606	chelatase, subunit chli
AP033_22295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AP033_22296	COG0129	dihydroxy-acid dehydratase activity
AP033_22298	COG0604	alcohol dehydrogenase
AP033_22300	COG0425	Belongs to the sulfur carrier protein TusA family
AP033_22302	COG2119	membrane
AP033_22303	COG0752	glycyl-tRNA synthetase alpha subunit
AP033_22304	COG0751	glycine-tRNA ligase activity
AP033_22305	COG3977	Valine--pyruvate aminotransferase
AP033_22306	COG0071	Belongs to the small heat shock protein (HSP20) family
AP033_22309	COG0187	DNA topoisomerase II activity
AP033_22310	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AP033_22311	COG0592	DNA-directed DNA polymerase activity
AP033_22312	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AP033_22315	COG1126	abc transporter atp-binding protein
AP033_22316	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AP033_22317	COG0594	ribonuclease P activity
AP033_22318	COG0706	membrane insertase activity
AP033_22319	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AP033_22320	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AP033_22321	COG0445	tRNA wobble uridine modification
AP033_22322	COG0357	Ribosomal RNA small subunit methyltransferase G
AP033_22323	COG1192	Involved in chromosome partitioning
AP033_22324	COG1475	DNA binding
AP033_22325	COG3312	ion transport
AP033_22326	COG0356	it plays a direct role in the translocation of protons across the membrane
AP033_22328	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AP033_22329	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AP033_22330	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AP033_22331	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AP033_22332	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AP033_22333	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AP033_22335	COG2814	Major facilitator Superfamily
AP033_22336	COG0583	DNA-binding transcription factor activity
AP033_22337	COG0183	Belongs to the thiolase family
AP033_22338	COG1250	3-hydroxyacyl-CoA dehydrogenase
AP033_22338	COG1024	Enoyl-CoA hydratase
AP033_22339	COG1739	Uncharacterized protein family UPF0029
AP033_22340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AP033_22341	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
AP033_22349	COG0583	DNA-binding transcription factor activity
AP033_22350	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AP033_22351	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AP033_22352	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AP033_22353	COG1309	transcriptional regulator
AP033_22362	COG0747	negative chemotaxis
AP033_22364	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AP033_22366	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AP033_22367	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AP033_22369	COG0210	DNA helicase
AP033_22370	COG1280	lysine exporter protein (LysE YggA)
AP033_22372	COG0405	Gamma-glutamyltransferase
AP033_22373	COG2962	Rard protein
AP033_22374	COG0514	ATP-dependent DNA helicase (RecQ)
AP033_22377	COG1132	(ABC) transporter
AP033_22378	COG4774	siderophore transport
AP033_22379	COG1120	ATPase activity
AP033_22383	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AP033_22384	COG1263	PTS System
AP033_22384	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AP033_22385	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AP033_22387	COG1561	YicC-like family, N-terminal region
AP033_22388	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AP033_22389	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AP033_22390	COG1560	Kdo2-lipid A biosynthetic process
AP033_22391	COG1560	Kdo2-lipid A biosynthetic process
AP033_22392	COG1309	transcriptional regulator
AP033_22393	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AP033_22403	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AP033_22404	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AP033_22416	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AP033_22417	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AP033_22419	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AP033_22420	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AP033_22421	COG0859	PFAM glycosyl transferase family 9
AP033_22422	COG0463	Glycosyl transferase, family 2
AP033_22423	COG0859	PFAM glycosyl transferase family 9
AP033_22424	COG3642	lipopolysaccharide core region biosynthetic process
AP033_22430	COG1519	Transferase
AP033_22437	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AP033_22438	COG0662	Cupin 2, conserved barrel domain protein
AP033_22438	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AP033_22439	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AP033_22440	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AP033_22441	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AP033_22447	COG0318	PFAM AMP-dependent synthetase and ligase
AP033_22448	COG1454	alcohol dehydrogenase
AP033_22448	COG1012	belongs to the aldehyde dehydrogenase family
AP033_22451	COG5433	transposase activity
AP033_22452	COG5433	transposase activity
AP033_22458	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AP033_22459	COG0668	transmembrane transport
AP033_22460	COG1573	uracil-dna glycosylase
AP033_22462	COG3068	Protein conserved in bacteria
AP033_22464	COG1940	carbohydrate kinase activity
AP033_22465	COG1253	flavin adenine dinucleotide binding
AP033_22466	COG0776	regulation of translation
AP033_22468	COG0151	Belongs to the GarS family
AP033_22469	COG0138	bifunctional purine biosynthesis protein purh
AP033_22470	COG0789	Transcriptional regulator
AP033_22471	COG3710	Transcriptional regulator
AP033_22472	COG0531	amino acid
AP033_22473	COG1982	Orn Lys Arg decarboxylase major
AP033_22474	COG0840	transmembrane signaling receptor activity
AP033_22477	COG0800	Aldolase
AP033_22479	COG3265	gluconokinase activity
AP033_22480	COG0129	dihydroxy-acid dehydratase activity
AP033_22481	COG1609	Transcriptional regulator
AP033_22483	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AP033_22484	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AP033_22485	COG2264	protein methyltransferase activity
AP033_22486	COG0439	Biotin carboxylase
AP033_22487	COG0511	ligase activity, forming carbon-carbon bonds
AP033_22488	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AP033_22489	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AP033_22492	COG2814	Major facilitator Superfamily
AP033_22493	COG2205	protein histidine kinase activity
AP033_22493	COG0784	Response regulator, receiver
AP033_22494	COG0248	Ppx GppA phosphatase
AP033_22495	COG0513	Belongs to the DEAD box helicase family
AP033_22496	COG3118	belongs to the thioredoxin family
AP033_22497	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AP033_22499	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AP033_22508	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AP033_22510	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AP033_22512	COG1072	(Pantothenic acid kinase))
AP033_22517	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AP033_22518	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AP033_22519	COG0250	Participates in transcription elongation, termination and antitermination
AP033_22520	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AP033_22521	COG0081	regulation of translation
AP033_22522	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AP033_22523	COG0222	ribosome binding
AP033_22524	COG0085	RNA polymerase activity
AP033_22525	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AP033_22526	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AP033_22527	COG2816	NAD+ diphosphatase activity
AP033_22528	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AP033_22531	COG4942	peptidase
AP033_22532	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AP033_22534	COG0471	metal ion transport
AP033_22535	COG0688	phosphatidylethanolamine metabolic process
AP033_22536	COG1162	GTPase activity
AP033_22537	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AP033_22547	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AP033_22548	COG0802	atpase or kinase
AP033_22550	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AP033_22551	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AP033_22552	COG1923	regulation of RNA biosynthetic process
AP033_22553	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AP033_22554	COG0330	HflC and HflK could
AP033_22555	COG0330	HflC and HflK could
AP033_22556	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AP033_22557	COG2900	Belongs to the SlyX family
AP033_22559	COG0545	Peptidyl-prolyl cis-trans isomerase
AP033_22560	COG2964	Protein conserved in bacteria
AP033_22561	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AP033_22562	COG2923	Belongs to the DsrF TusC family
AP033_22564	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AP033_22565	COG0049	tRNA binding
AP033_22566	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AP033_22567	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AP033_22568	COG2906	2 iron, 2 sulfur cluster binding
AP033_22570	COG0360	Binds together with S18 to 16S ribosomal RNA
AP033_22571	COG2965	DNA replication, synthesis of RNA primer
AP033_22572	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AP033_22573	COG0359	binds to the 23S rRNA
AP033_22575	COG0305	Participates in initiation and elongation during chromosome replication
AP033_22576	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AP033_22577	COG0432	Pfam Uncharacterised protein family UPF0047
AP033_22578	COG0166	Belongs to the GPI family
AP033_22581	COG0735	belongs to the Fur family
AP033_22582	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AP033_22586	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AP033_22587	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AP033_22588	COG0175	sulfate reduction
AP033_22596	COG1410	methionine synthase
AP033_22596	COG0646	methionine synthase
AP033_22597	COG0527	aspartate kinase activity
AP033_22598	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AP033_22600	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AP033_22603	COG0629	single-stranded DNA binding
AP033_22604	COG2199	diguanylate cyclase activity
AP033_22604	COG2200	EAL domain
AP033_22609	COG3409	Peptidoglycan-binding domain 1 protein
AP033_22609	COG3267	Type II secretory pathway component ExeA
AP033_22611	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AP033_22612	COG1459	type II secretion system
AP033_22621	COG1077	Cell shape determining protein MreB Mrl
AP033_22622	COG1792	Involved in formation and maintenance of cell shape
AP033_22623	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AP033_22624	COG0424	maF-like protein
AP033_22625	COG1530	ribonuclease E activity
AP033_22626	COG3164	Protein of unknown function
AP033_22627	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AP033_22628	COG0312	modulator of DNA gyrase
AP033_22629	COG2235	arginine
AP033_22633	COG0589	response to stress
AP033_22636	COG1438	arginine binding
AP033_22637	COG0039	L-malate dehydrogenase activity
AP033_22638	COG0531	amino acid
AP033_22639	COG0142	geranyltranstransferase activity
AP033_22640	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AP033_22641	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AP033_22642	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AP033_22643	COG2966	Psort location CytoplasmicMembrane, score
AP033_22644	COG3610	response to peptide
AP033_22646	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AP033_22647	COG2967	ApaG domain
AP033_22648	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AP033_22649	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AP033_22650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AP033_22651	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AP033_22652	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA