locus-tag	class	description
AN947_00025	COG0217	transcriptional regulatory protein
AN947_00030	COG2084	Dehydrogenase
AN947_00050	COG2909	trisaccharide binding
AN947_00055	COG0058	SHG alpha-glucan phosphorylase activity
AN947_00060	COG1640	4-alpha-glucanotransferase
AN947_00065	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AN947_00075	COG3501	Rhs element vgr protein
AN947_00110	COG0471	metal ion transport
AN947_00115	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AN947_00160	COG0671	phosphoesterase, PA-phosphatase related
AN947_00165	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AN947_00175	COG1999	signal sequence binding
AN947_00190	COG0786	glutamate:sodium symporter activity
AN947_00210	COG1566	PFAM secretion protein HlyD family protein
AN947_00220	COG3706	GGDEF domain
AN947_00245	COG3272	Protein of unknown function (DUF1722)
AN947_00255	COG0415	Belongs to the DNA photolyase family
AN947_00260	COG1376	ErfK ybiS ycfS ynhG family protein
AN947_00260	COG1388	LysM domain
AN947_00275	COG0513	Belongs to the DEAD box helicase family
AN947_00310	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AN947_00315	COG0573	inorganic phosphate transmembrane transporter activity
AN947_00320	COG0581	inorganic phosphate transmembrane transporter activity
AN947_00325	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AN947_00345	COG0659	secondary active sulfate transmembrane transporter activity
AN947_00355	COG0739	heme binding
AN947_00360	COG3300	MHYT domain
AN947_00360	COG5001	Diguanylate cyclase
AN947_00365	COG0583	DNA-binding transcription factor activity
AN947_00370	COG2814	Major facilitator Superfamily
AN947_00395	COG1301	dicarboxylic acid transport
AN947_00405	COG1342	Belongs to the UPF0251 family
AN947_00440	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AN947_00445	COG0673	inositol 2-dehydrogenase activity
AN947_00455	COG2200	EAL domain
AN947_00455	COG2771	luxR family
AN947_00460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AN947_00470	COG0564	pseudouridine synthase activity
AN947_00585	COG1869	D-ribose catabolic process
AN947_00590	COG1129	ABC transporter
AN947_00595	COG1172	Belongs to the binding-protein-dependent transport system permease family
AN947_00600	COG1879	ABC-type sugar transport system periplasmic component
AN947_00605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AN947_00610	COG1609	Transcriptional regulator
AN947_00620	COG3201	nicotinamide mononucleotide transporter
AN947_00625	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AN947_00635	COG0584	glycerophosphoryl diester phosphodiesterase
AN947_00640	COG2271	Major facilitator Superfamily
AN947_00680	COG0579	oxidoreductase
AN947_00690	COG0242	peptide deformylase activity
AN947_00700	COG1320	monovalent cation:proton antiporter activity
AN947_00705	COG2212	antiporter activity
AN947_00725	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AN947_00725	COG2111	Na H antiporter
AN947_00740	COG0814	amino acid
AN947_00755	COG3530	Putative quorum-sensing-regulated virulence factor
AN947_00765	COG5002	protein histidine kinase activity
AN947_00765	COG5001	Diguanylate cyclase
AN947_00770	COG1278	Cold shock
AN947_00785	COG2304	oxidoreductase activity
AN947_00805	COG0714	Associated with various cellular activities
AN947_00810	COG0840	transmembrane signaling receptor activity
AN947_00825	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AN947_00830	COG2195	Cleaves the N-terminal amino acid of tripeptides
AN947_00840	COG3604	Transcriptional regulator
AN947_00845	COG1017	nitric oxide dioxygenase activity
AN947_00845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AN947_00850	COG1278	Cold shock
AN947_00855	COG3036	rescue of stalled ribosome
AN947_00880	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AN947_00880	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AN947_00885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AN947_00895	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AN947_00910	COG0516	GMP reductase activity
AN947_00935	COG1943	Transposase
AN947_00940	COG0513	Belongs to the DEAD box helicase family
AN947_00945	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AN947_00950	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AN947_00955	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AN947_00965	COG0784	Response regulator, receiver
AN947_00965	COG3437	response regulator, receiver
AN947_00970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AN947_00970	COG4191	Histidine kinase
AN947_00980	COG1757	Na H antiporter
AN947_00985	COG2814	Major facilitator Superfamily
AN947_01000	COG3706	GGDEF domain
AN947_01005	COG3240	lipase activity
AN947_01015	COG0840	transmembrane signaling receptor activity
AN947_01020	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AN947_01025	COG5380	lipid catabolic process
AN947_01030	COG4412	M6 family metalloprotease domain protein
AN947_01030	COG3291	Pkd domain containing protein
AN947_01050	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN947_01055	COG4605	iron ion homeostasis
AN947_01060	COG4604	ABC transporter, ATP-binding protein
AN947_01080	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AN947_01100	COG0745	RESPONSE REGULATOR receiver
AN947_01110	COG3623	hexulose-6-phosphate isomerase
AN947_01115	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AN947_01120	COG0561	phosphatase activity
AN947_01150	COG3038	cytochrome b561
AN947_01155	COG0366	Alpha amylase catalytic
AN947_01180	COG0745	RESPONSE REGULATOR receiver
AN947_01185	COG5002	protein histidine kinase activity
AN947_01210	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AN947_01225	COG2814	Major facilitator Superfamily
AN947_01240	COG1686	Belongs to the peptidase S11 family
AN947_01260	COG1943	Transposase
AN947_01265	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AN947_01265	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AN947_01270	COG0509	glycine decarboxylation via glycine cleavage system
AN947_01275	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AN947_01285	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AN947_01295	COG3039	Transposase
AN947_01320	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AN947_01330	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AN947_01335	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AN947_01375	COG1028	Short-chain dehydrogenase reductase Sdr
AN947_01435	COG0494	nUDIX hydrolase
AN947_01450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AN947_01455	COG3040	lipid binding
AN947_01480	COG3041	Addiction module toxin RelE StbE family
AN947_01545	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AN947_01550	COG1280	lysine exporter protein (LysE YggA)
AN947_01720	COG3549	Plasmid maintenance system killer
AN947_01725	COG3093	addiction module antidote protein HigA
AN947_01730	COG1619	proteins homologs of microcin C7 resistance protein MccF
AN947_01750	COG3040	lipid binding
AN947_01815	COG4977	sequence-specific DNA binding
AN947_01865	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
AN947_01870	COG2944	sequence-specific DNA binding
AN947_01885	COG3039	Transposase
AN947_01905	COG0346	lactoylglutathione lyase activity
AN947_01990	COG1943	Transposase
AN947_02040	COG0346	lactoylglutathione lyase activity
AN947_02060	COG1328	CTP reductase activity
AN947_02065	COG0602	queuosine metabolic process
AN947_02080	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AN947_02080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AN947_02080	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AN947_02085	COG1105	Belongs to the carbohydrate kinase PfkB family
AN947_02090	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AN947_02090	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AN947_02095	COG1609	Transcriptional regulator
AN947_02100	COG0420	3'-5' exonuclease activity
AN947_02105	COG0419	ATPase involved in DNA repair
AN947_02110	COG0784	Response regulator, receiver
AN947_02110	COG2205	protein histidine kinase activity
AN947_02115	COG0156	8-amino-7-oxononanoate synthase activity
AN947_02130	COG0523	cobalamin synthesis protein
AN947_02140	COG3158	transport of potassium into the cell
AN947_02145	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AN947_02145	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AN947_02145	COG1013	pyruvate-flavodoxin oxidoreductase activity
AN947_02145	COG0674	pyruvate-flavodoxin oxidoreductase activity
AN947_02155	COG0745	RESPONSE REGULATOR receiver
AN947_02160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AN947_02165	COG0586	Pfam SNARE associated Golgi protein
AN947_02175	COG2200	EAL domain
AN947_02185	COG3038	cytochrome b561
AN947_02195	COG2116	formate transmembrane transporter activity
AN947_02200	COG0583	DNA-binding transcription factor activity
AN947_02215	COG0737	Belongs to the 5'-nucleotidase family
AN947_02230	COG2824	Alkylphosphonate utilization operon protein PhnA
AN947_02285	COG3706	GGDEF domain
AN947_02300	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AN947_02305	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AN947_02315	COG0745	RESPONSE REGULATOR receiver
AN947_02335	COG4128	Pfam Zonular occludens toxin
AN947_02370	COG0023	Translation Initiation Factor
AN947_02380	COG1181	Belongs to the D-alanine--D-alanine ligase family
AN947_02390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AN947_02390	COG1042	CoA-binding domain protein
AN947_02390	COG0045	succinate-CoA ligase (ADP-forming) activity
AN947_02395	COG0583	DNA-binding transcription factor activity
AN947_02400	COG1629	transport
AN947_02400	COG4771	TonB-dependent receptor
AN947_02415	COG2050	protein possibly involved in aromatic compounds catabolism
AN947_02435	COG0625	glutathione transferase activity
AN947_02450	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AN947_02455	COG4172	Belongs to the ABC transporter superfamily
AN947_02460	COG4239	(ABC) transporter, permease
AN947_02465	COG4174	ABC transporter (Permease)
AN947_02470	COG4166	transmembrane transport
AN947_02515	COG3842	ATPase activity
AN947_02525	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AN947_02535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AN947_02540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AN947_02545	COG1011	Hydrolase
AN947_02555	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AN947_02560	COG1970	mechanosensitive ion channel activity
AN947_02565	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AN947_02570	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AN947_02570	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AN947_02575	COG0302	gtp cyclohydrolase
AN947_02585	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AN947_02595	COG2897	thiosulfate sulfurtransferase activity
AN947_02600	COG2390	Transcriptional regulator
AN947_02610	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AN947_02615	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AN947_02640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AN947_02665	COG0583	DNA-binding transcription factor activity
AN947_02670	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AN947_02700	COG0640	Transcriptional regulator
AN947_02710	COG0446	pyridine nucleotide-disulphide oxidoreductase
AN947_02755	COG1263	PTS System
AN947_02755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AN947_02770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AN947_02775	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AN947_02785	COG2885	chlorophyll binding
AN947_02790	COG0545	Peptidyl-prolyl cis-trans isomerase
AN947_02795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AN947_02800	COG0840	transmembrane signaling receptor activity
AN947_02810	COG3069	C4-dicarboxylate transmembrane transporter activity
AN947_02815	COG1760	l-serine dehydratase
AN947_02840	COG1609	Transcriptional regulator
AN947_02845	COG2197	response regulator
AN947_02850	COG3850	Histidine kinase
AN947_02855	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AN947_02865	COG0243	molybdopterin cofactor binding
AN947_02885	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AN947_02890	COG2197	response regulator
AN947_02895	COG3851	Histidine kinase
AN947_02900	COG2271	Major facilitator Superfamily
AN947_02905	COG1840	ABC-type Fe3 transport system, periplasmic component
AN947_02915	COG3842	ATPase activity
AN947_02920	COG3243	poly(R)-hydroxyalkanoic acid synthase
AN947_02930	COG0183	Belongs to the thiolase family
AN947_02940	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AN947_02945	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AN947_02960	COG2131	deaminase
AN947_03025	COG3706	GGDEF domain
AN947_03030	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AN947_03040	COG1979	alcohol dehydrogenase
AN947_03055	COG4191	Histidine kinase
AN947_03060	COG1840	ABC-type Fe3 transport system, periplasmic component
AN947_03065	COG2271	Major facilitator Superfamily
AN947_03070	COG0469	pyruvate kinase activity
AN947_03075	COG2198	Histidine kinase
AN947_03075	COG2205	protein histidine kinase activity
AN947_03075	COG0784	Response regulator, receiver
AN947_03080	COG1879	ABC-type sugar transport system periplasmic component
AN947_03085	COG1803	Methylglyoxal synthase
AN947_03090	COG1335	isochorismatase
AN947_03095	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AN947_03110	COG0210	DNA helicase
AN947_03115	COG1289	transmembrane transporter activity
AN947_03145	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AN947_03150	COG4149	molybdate abc transporter
AN947_03155	COG0725	ABC transporter, periplasmic molybdate-binding protein
AN947_03160	COG1492	cobalamin metabolic process
AN947_03205	COG5002	protein histidine kinase activity
AN947_03205	COG0784	Response regulator, receiver
AN947_03210	COG1879	ABC-type sugar transport system periplasmic component
AN947_03220	COG2827	Endonuclease containing a URI domain
AN947_03250	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AN947_03255	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AN947_03265	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AN947_03270	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
AN947_03275	COG0247	lactate metabolic process
AN947_03280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AN947_03285	COG3118	belongs to the thioredoxin family
AN947_03315	COG0583	DNA-binding transcription factor activity
AN947_03320	COG4160	amino acid transport
AN947_03325	COG4215	(ABC) transporter
AN947_03330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AN947_03335	COG1126	abc transporter atp-binding protein
AN947_03345	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AN947_03355	COG0494	nUDIX hydrolase
AN947_03360	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AN947_03370	COG1309	transcriptional regulator
AN947_03375	COG0513	Belongs to the DEAD box helicase family
AN947_03380	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
AN947_03390	COG0814	amino acid
AN947_03395	COG0840	transmembrane signaling receptor activity
AN947_03400	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AN947_03410	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AN947_03420	COG1984	allophanate hydrolase subunit 2
AN947_03435	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AN947_03440	COG4181	ATPase activity
AN947_03450	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AN947_03455	COG1716	ATPase activity
AN947_03455	COG5001	Diguanylate cyclase
AN947_03470	COG0484	heat shock protein binding
AN947_03515	COG0546	phosphoglycolate phosphatase activity
AN947_03530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AN947_03535	COG1368	sulfuric ester hydrolase activity
AN947_03545	COG0513	Belongs to the DEAD box helicase family
AN947_03550	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AN947_03560	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AN947_03570	COG3046	protein related to deoxyribodipyrimidine photolyase
AN947_03575	COG3397	chitin binding
AN947_03580	COG3227	Zinc metalloprotease (Elastase)
AN947_03590	COG0010	Belongs to the arginase family
AN947_03595	COG1166	arginine decarboxylase activity
AN947_03605	COG2239	Acts as a magnesium transporter
AN947_03610	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AN947_03625	COG0527	aspartate kinase activity
AN947_03630	COG0662	Cupin 2, conserved barrel domain protein
AN947_03640	COG0456	acetyltransferase
AN947_03645	COG2154	pterin-4-alpha-carbinolamine dehydratase
AN947_03650	COG3186	Phenylalanine-4-hydroxylase
AN947_03655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AN947_03670	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AN947_03675	COG0583	DNA-binding transcription factor activity
AN947_03695	COG1253	flavin adenine dinucleotide binding
AN947_03700	COG1765	OsmC-like protein
AN947_03730	COG0531	amino acid
AN947_03735	COG3706	GGDEF domain
AN947_03745	COG3279	Response regulator of the LytR AlgR family
AN947_03750	COG3275	phosphorelay sensor kinase activity
AN947_03765	COG1136	(ABC) transporter
AN947_03765	COG0577	efflux transmembrane transporter activity
AN947_03770	COG1136	(ABC) transporter
AN947_03785	COG4989	oxidoreductase activity
AN947_03790	COG0366	Alpha amylase catalytic
AN947_03805	COG2067	long-chain fatty acid transport protein
AN947_03810	COG2267	carboxylic ester hydrolase activity
AN947_03820	COG3227	Zinc metalloprotease (Elastase)
AN947_03830	COG3047	cAMP biosynthetic process
AN947_03840	COG1686	Belongs to the peptidase S11 family
AN947_03845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AN947_03850	COG1271	oxidase subunit
AN947_03855	COG1294	oxidase, subunit
AN947_03865	COG3048	D-serine ammonia-lyase activity
AN947_03870	COG0583	DNA-binding transcription factor activity
AN947_03915	COG1063	alcohol dehydrogenase
AN947_03930	COG0693	protein deglycase activity
AN947_03945	COG0346	lactoylglutathione lyase activity
AN947_03965	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AN947_03970	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AN947_03975	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AN947_03980	COG0363	glucosamine-6-phosphate deaminase activity
AN947_03985	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AN947_04010	COG1929	Belongs to the glycerate kinase type-1 family
AN947_04015	COG2610	gluconate transmembrane transporter activity
AN947_04020	COG3835	regulator
AN947_04030	COG0748	coenzyme F420 binding
AN947_04035	COG3721	Heme iron utilization protein
AN947_04045	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AN947_04050	COG0811	peptide transport
AN947_04055	COG0848	biopolymer transport protein
AN947_04060	COG4558	Periplasmic binding protein
AN947_04070	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AN947_04105	COG0633	Ferredoxin
AN947_04105	COG3217	Mosc domain protein beta barrel domain protein
AN947_04105	COG0633	Ferredoxin
AN947_04105	COG3217	Mosc domain protein beta barrel domain protein
AN947_04110	COG0418	dihydroorotase activity
AN947_04120	COG3152	Membrane
AN947_04130	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AN947_04135	COG2354	Protein conserved in bacteria
AN947_04140	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AN947_04145	COG1278	Cold shock
AN947_04170	COG3706	GGDEF domain
AN947_04175	COG1349	DNA-binding transcription factor activity
AN947_04190	COG3833	ABC-type maltose transport systems, permease component
AN947_04195	COG1175	transmembrane transport
AN947_04205	COG3842	ATPase activity
AN947_04210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AN947_04225	COG0393	Putative heavy-metal-binding
AN947_04230	COG2197	response regulator
AN947_04235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AN947_04240	COG0784	Response regulator, receiver
AN947_04240	COG0835	chemotaxis
AN947_04245	COG1846	Transcriptional regulator
AN947_04250	COG3706	GGDEF domain
AN947_04290	COG0583	DNA-binding transcription factor activity
AN947_04295	COG5001	Diguanylate cyclase
AN947_04305	COG1741	Belongs to the pirin family
AN947_04310	COG3123	guanosine phosphorylase activity
AN947_04320	COG2211	Major facilitator Superfamily
AN947_04330	COG0840	transmembrane signaling receptor activity
AN947_04335	COG1067	ATP-dependent peptidase activity
AN947_04345	COG4172	Belongs to the ABC transporter superfamily
AN947_04370	COG0583	DNA-binding transcription factor activity
AN947_04375	COG1620	l-lactate permease
AN947_04380	COG1304	FMN binding
AN947_04390	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AN947_04400	COG0840	transmembrane signaling receptor activity
AN947_04410	COG0513	Belongs to the DEAD box helicase family
AN947_04415	COG0583	DNA-binding transcription factor activity
AN947_04425	COG1902	pentaerythritol trinitrate reductase activity
AN947_04435	COG1132	(ABC) transporter
AN947_04445	COG1902	pentaerythritol trinitrate reductase activity
AN947_04455	COG1280	lysine exporter protein (LysE YggA)
AN947_04460	COG2207	Transcriptional regulator
AN947_04480	COG1846	Transcriptional regulator
AN947_04485	COG1764	response to oxidative stress
AN947_04490	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AN947_04495	COG0697	spore germination
AN947_04505	COG0700	Nucleoside recognition
AN947_04510	COG3366	ferrous iron transmembrane transporter activity
AN947_04525	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AN947_04530	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AN947_04535	COG2259	Doxx family
AN947_04560	COG0363	glucosamine-6-phosphate deaminase activity
AN947_04575	COG4580	involved in the transport of maltose and maltodextrins
AN947_04590	COG0840	transmembrane signaling receptor activity
AN947_04605	COG0840	transmembrane signaling receptor activity
AN947_04615	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AN947_04620	COG1126	abc transporter atp-binding protein
AN947_04630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AN947_04635	COG4597	amino acid ABC transporter
AN947_04640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AN947_04650	COG0739	heme binding
AN947_04665	COG0246	Mannitol dehydrogenase
AN947_04670	COG3722	fumarate hydratase activity
AN947_04675	COG0673	inositol 2-dehydrogenase activity
AN947_04705	COG2910	NAD(P)H-binding
AN947_04715	COG0840	transmembrane signaling receptor activity
AN947_04720	COG4221	oxidoreductase activity
AN947_04730	COG1901	pseudouridine methyltransferase
AN947_04735	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AN947_04740	COG0531	amino acid
AN947_04745	COG1982	Orn Lys Arg decarboxylase major
AN947_04775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AN947_04800	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AN947_04810	COG0259	pyridoxamine-phosphate oxidase activity
AN947_04840	COG0745	RESPONSE REGULATOR receiver
AN947_04860	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AN947_04865	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AN947_04870	COG0840	transmembrane signaling receptor activity
AN947_04875	COG0835	chemotaxis
AN947_04880	COG0835	chemotaxis
AN947_04885	COG2198	Histidine kinase
AN947_04885	COG0643	Histidine kinase
AN947_04905	COG0601	transmembrane transport
AN947_04910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AN947_04920	COG2194	sulfuric ester hydrolase activity
AN947_04925	COG0642	Histidine kinase
AN947_04930	COG0745	RESPONSE REGULATOR receiver
AN947_04960	COG1444	tRNA N-acetyltransferase activity
AN947_04965	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AN947_04985	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AN947_04990	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AN947_05000	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AN947_05005	COG0594	ribonuclease P activity
AN947_05010	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AN947_05015	COG1126	abc transporter atp-binding protein
AN947_05030	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AN947_05035	COG0592	DNA-directed DNA polymerase activity
AN947_05040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AN947_05045	COG0187	DNA topoisomerase II activity
AN947_05060	COG0071	Belongs to the small heat shock protein (HSP20) family
AN947_05065	COG3977	Valine--pyruvate aminotransferase
AN947_05070	COG0751	glycine-tRNA ligase activity
AN947_05075	COG0752	glycyl-tRNA synthetase alpha subunit
AN947_05080	COG2119	membrane
AN947_05090	COG0425	Belongs to the sulfur carrier protein TusA family
AN947_05100	COG0604	alcohol dehydrogenase
AN947_05110	COG0129	dihydroxy-acid dehydratase activity
AN947_05115	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AN947_05130	COG0606	chelatase, subunit chli
AN947_05135	COG0204	Acyl-transferase
AN947_05140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AN947_05155	COG3084	Protein conserved in bacteria
AN947_05165	COG4326	sporulation control protein
AN947_05170	COG1272	protein, Hemolysin III
AN947_05180	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AN947_05185	COG0569	domain protein
AN947_05190	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AN947_05190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AN947_05195	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AN947_05200	COG0242	peptide deformylase activity
AN947_05205	COG1652	LysM domain
AN947_05210	COG0758	DNA mediated transformation
AN947_05215	COG2922	Belongs to the Smg family
AN947_05220	COG0551	DNA topoisomerase type I activity
AN947_05225	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AN947_05230	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AN947_05235	COG0009	L-threonylcarbamoyladenylate synthase
AN947_05240	COG0408	coproporphyrinogen oxidase activity
AN947_05245	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AN947_05255	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AN947_05295	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AN947_05300	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AN947_05310	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AN947_05315	COG2104	thiamine diphosphate biosynthetic process
AN947_05320	COG2022	thiamine diphosphate biosynthetic process
AN947_05325	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AN947_05330	COG0006	proline dipeptidase activity
AN947_05330	COG0006	proline dipeptidase activity
AN947_05350	COG1522	sequence-specific DNA binding
AN947_05355	COG5001	Diguanylate cyclase
AN947_05355	COG5002	protein histidine kinase activity
AN947_05360	COG0742	ribosomal rna small subunit methyltransferase
AN947_05370	COG0697	spore germination
AN947_05375	COG0589	response to stress
AN947_05385	COG1528	Iron-storage protein
AN947_05395	COG2081	HI0933 family
AN947_05405	COG1322	Protein conserved in bacteria
AN947_05410	COG2226	methyltransferase
AN947_05420	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AN947_05425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AN947_05430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AN947_05435	COG0805	protein transport
AN947_05440	COG1858	cytochrome C peroxidase
AN947_05445	COG0534	Mate efflux family protein
AN947_05455	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AN947_05460	COG2937	Belongs to the GPAT DAPAT family
AN947_05465	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AN947_05470	COG3161	chorismate lyase activity
AN947_05480	COG1580	Controls the rotational direction of flagella during chemotaxis
AN947_05485	COG0840	transmembrane signaling receptor activity
AN947_05495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AN947_05520	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AN947_05520	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AN947_05525	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AN947_05540	COG3078	GTPase activator activity
AN947_05550	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AN947_05555	COG3071	HemY protein
AN947_05560	COG2959	enzyme of heme biosynthesis
AN947_05565	COG1587	Uroporphyrinogen-III synthase
AN947_05570	COG0181	hydroxymethylbilane synthase activity
AN947_05580	COG3072	Adenylate cyclase
AN947_05585	COG1965	Belongs to the frataxin family
AN947_05595	COG0019	diaminopimelate decarboxylase activity
AN947_05600	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AN947_05610	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AN947_05615	COG1011	Hydrolase
AN947_05620	COG3287	FIST C domain
AN947_05620	COG2199	diguanylate cyclase activity
AN947_05620	COG2200	EAL domain
AN947_05640	COG0561	phosphatase activity
AN947_05645	COG2267	carboxylic ester hydrolase activity
AN947_05650	COG1280	lysine exporter protein (LysE YggA)
AN947_05655	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AN947_05660	COG0783	Belongs to the Dps family
AN947_05695	COG0742	ribosomal rna small subunit methyltransferase
AN947_05705	COG2884	Cell division ATP-binding protein ftsE
AN947_05710	COG2177	Part of the ABC transporter FtsEX involved in
AN947_05715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AN947_05735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AN947_05745	COG1404	Belongs to the peptidase S8 family
AN947_05750	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AN947_05785	COG0583	DNA-binding transcription factor activity
AN947_05790	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AN947_05795	COG2960	long-chain fatty acid transporting porin activity
AN947_05800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AN947_05805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AN947_05810	COG1309	transcriptional regulator
AN947_05865	COG0747	negative chemotaxis
AN947_05875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AN947_05885	COG2131	deaminase
AN947_05950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AN947_05955	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AN947_05965	COG0210	DNA helicase
AN947_05970	COG1280	lysine exporter protein (LysE YggA)
AN947_05985	COG2962	Rard protein
AN947_05990	COG0514	ATP-dependent DNA helicase (RecQ)
AN947_06005	COG1132	(ABC) transporter
AN947_06010	COG4774	siderophore transport
AN947_06015	COG1120	ATPase activity
AN947_06040	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AN947_06045	COG1263	PTS System
AN947_06045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AN947_06055	COG1561	YicC-like family, N-terminal region
AN947_06060	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AN947_06065	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AN947_06070	COG1560	Kdo2-lipid A biosynthetic process
AN947_06075	COG1560	Kdo2-lipid A biosynthetic process
AN947_06080	COG1309	transcriptional regulator
AN947_06085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AN947_06100	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AN947_06105	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AN947_06115	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AN947_06120	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AN947_06125	COG0859	PFAM glycosyl transferase family 9
AN947_06130	COG0463	Glycosyl transferase, family 2
AN947_06135	COG0859	PFAM glycosyl transferase family 9
AN947_06140	COG3642	lipopolysaccharide core region biosynthetic process
AN947_06170	COG1519	Transferase
AN947_06205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AN947_06215	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AN947_06250	COG5433	transposase activity
AN947_06270	COG1051	belongs to the nudix hydrolase family
AN947_06295	COG1215	transferase activity, transferring glycosyl groups
AN947_06300	COG1216	Glycosyl transferase, family 2
AN947_06310	COG0367	asparagine synthase
AN947_06315	COG0438	transferase activity, transferring glycosyl groups
AN947_06320	COG0662	Cupin 2, conserved barrel domain protein
AN947_06320	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AN947_06335	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AN947_06355	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AN947_06370	COG0668	transmembrane transport
AN947_06380	COG3068	Protein conserved in bacteria
AN947_06385	COG1253	flavin adenine dinucleotide binding
AN947_06395	COG0776	regulation of translation
AN947_06405	COG0151	Belongs to the GarS family
AN947_06410	COG0138	bifunctional purine biosynthesis protein purh
AN947_06420	COG0789	Transcriptional regulator
AN947_06425	COG3710	Transcriptional regulator
AN947_06430	COG0531	amino acid
AN947_06435	COG1982	Orn Lys Arg decarboxylase major
AN947_06440	COG0840	transmembrane signaling receptor activity
AN947_06460	COG0800	Aldolase
AN947_06475	COG0129	dihydroxy-acid dehydratase activity
AN947_06480	COG1609	Transcriptional regulator
AN947_06485	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AN947_06490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AN947_06495	COG2264	protein methyltransferase activity
AN947_06500	COG0439	Biotin carboxylase
AN947_06505	COG0511	ligase activity, forming carbon-carbon bonds
AN947_06510	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AN947_06515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AN947_06535	COG2814	Major facilitator Superfamily
AN947_06540	COG0784	Response regulator, receiver
AN947_06540	COG2205	protein histidine kinase activity
AN947_06545	COG0248	Ppx GppA phosphatase
AN947_06550	COG0513	Belongs to the DEAD box helicase family
AN947_06555	COG3118	belongs to the thioredoxin family
AN947_06570	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AN947_06615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AN947_06630	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AN947_06640	COG1072	(Pantothenic acid kinase))
AN947_06665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AN947_06670	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AN947_06675	COG0250	Participates in transcription elongation, termination and antitermination
AN947_06680	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AN947_06685	COG0081	regulation of translation
AN947_06690	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AN947_06695	COG0222	ribosome binding
AN947_06700	COG0085	RNA polymerase activity
AN947_06705	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AN947_06710	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AN947_06715	COG2816	NAD+ diphosphatase activity
AN947_06720	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AN947_06735	COG4942	peptidase
AN947_06740	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AN947_06750	COG0471	metal ion transport
AN947_06755	COG0688	phosphatidylethanolamine metabolic process
AN947_06760	COG1162	GTPase activity
AN947_06765	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AN947_06810	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AN947_06815	COG0802	atpase or kinase
AN947_06825	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AN947_06830	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AN947_06835	COG1923	regulation of RNA biosynthetic process
AN947_06840	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AN947_06845	COG0330	HflC and HflK could
AN947_06850	COG0330	HflC and HflK could
AN947_06855	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AN947_06860	COG2900	Belongs to the SlyX family
AN947_06870	COG0545	Peptidyl-prolyl cis-trans isomerase
AN947_06875	COG2964	Protein conserved in bacteria
AN947_06880	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AN947_06885	COG2923	Belongs to the DsrF TusC family
AN947_06895	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AN947_06900	COG0049	tRNA binding
AN947_06905	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AN947_06910	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AN947_06915	COG2906	2 iron, 2 sulfur cluster binding
AN947_06925	COG0360	Binds together with S18 to 16S ribosomal RNA
AN947_06935	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AN947_06950	COG0305	Participates in initiation and elongation during chromosome replication
AN947_06955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AN947_06960	COG0432	Pfam Uncharacterised protein family UPF0047
AN947_06965	COG0166	Belongs to the GPI family
AN947_06980	COG0735	belongs to the Fur family
AN947_06985	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AN947_07010	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AN947_07020	COG0175	sulfate reduction
AN947_07060	COG0646	methionine synthase
AN947_07060	COG1410	methionine synthase
AN947_07065	COG0527	aspartate kinase activity
AN947_07070	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AN947_07080	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AN947_07095	COG0629	single-stranded DNA binding
AN947_07100	COG2200	EAL domain
AN947_07100	COG2199	diguanylate cyclase activity
AN947_07125	COG3409	Peptidoglycan-binding domain 1 protein
AN947_07125	COG3267	Type II secretory pathway component ExeA
AN947_07135	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AN947_07140	COG1459	type II secretion system
AN947_07185	COG1077	Cell shape determining protein MreB Mrl
AN947_07190	COG1792	Involved in formation and maintenance of cell shape
AN947_07195	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AN947_07200	COG0424	maF-like protein
AN947_07210	COG3164	Protein of unknown function
AN947_07215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AN947_07220	COG0312	modulator of DNA gyrase
AN947_07225	COG2235	arginine
AN947_07245	COG0589	response to stress
AN947_07260	COG1438	arginine binding
AN947_07265	COG0039	L-malate dehydrogenase activity
AN947_07270	COG0531	amino acid
AN947_07275	COG0531	amino acid
AN947_07280	COG0142	geranyltranstransferase activity
AN947_07285	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AN947_07290	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AN947_07295	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AN947_07300	COG2966	Psort location CytoplasmicMembrane, score
AN947_07305	COG3610	response to peptide
AN947_07315	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AN947_07320	COG2967	ApaG domain
AN947_07325	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AN947_07330	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AN947_07335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AN947_07340	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AN947_07345	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AN947_07400	COG0741	lytic transglycosylase activity
AN947_07405	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AN947_07410	COG1194	a g-specific adenine glycosylase
AN947_07415	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AN947_07425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AN947_07430	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AN947_07440	COG1872	DUF167
AN947_07445	COG0762	integral membrane protein
AN947_07450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AN947_07455	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AN947_07475	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AN947_07480	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AN947_07485	COG1678	Uncharacterized ACR, COG1678
AN947_07490	COG0189	ligase activity
AN947_07495	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AN947_07500	COG2356	endonuclease I
AN947_07505	COG3091	SprT-like family
AN947_07510	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AN947_07525	COG0583	DNA-binding transcription factor activity
AN947_07530	COG4771	TonB-dependent receptor
AN947_07535	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AN947_07540	COG0126	phosphoglycerate kinase activity
AN947_07545	COG0191	fructose-bisphosphate aldolase activity
AN947_07555	COG0668	transmembrane transport
AN947_07560	COG1279	arginine transmembrane transporter activity
AN947_07565	COG0583	DNA-binding transcription factor activity
AN947_07575	COG0469	pyruvate kinase activity
AN947_07580	COG1349	DNA-binding transcription factor activity
AN947_07585	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AN947_07590	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AN947_07640	COG0328	RNA-DNA hybrid ribonuclease activity
AN947_07665	COG0739	heme binding
AN947_07700	COG2003	Belongs to the UPF0758 family
AN947_07710	COG0840	transmembrane signaling receptor activity
AN947_07715	COG2207	Transcriptional regulator
AN947_07725	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AN947_07730	COG0582	viral genome integration into host DNA
AN947_07740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AN947_07745	COG0358	DNA primase activity
AN947_07750	COG1610	YqeY-like protein
AN947_07755	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AN947_07760	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AN947_07770	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AN947_07775	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AN947_07780	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AN947_07790	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AN947_07795	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AN947_07800	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AN947_07805	COG0585	pseudouridine synthase activity
AN947_07810	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AN947_07815	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AN947_07820	COG4942	peptidase
AN947_07820	COG1388	LysM domain
AN947_07825	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AN947_07830	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AN947_07850	COG4208	sulfate ABC transporter
AN947_07855	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AN947_07865	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AN947_07870	COG2137	regulation of response to DNA damage stimulus
AN947_07875	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AN947_07880	COG0527	aspartate kinase activity
AN947_07885	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AN947_07935	COG3630	sodium ion export across plasma membrane
AN947_07940	COG5016	pyruvate
AN947_07940	COG0511	ligase activity, forming carbon-carbon bonds
AN947_07945	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AN947_07955	COG1238	metal cluster binding
AN947_07960	COG0612	Peptidase, M16
AN947_07965	COG2918	glutathione biosynthetic process
AN947_07970	COG1854	S-ribosylhomocysteine lyase activity
AN947_07975	COG4536	flavin adenine dinucleotide binding
AN947_07980	COG4137	Cytochrome C assembly protein
AN947_07985	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AN947_07990	COG0228	four-way junction DNA binding
AN947_07995	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AN947_08000	COG0336	Belongs to the RNA methyltransferase TrmD family
AN947_08005	COG0335	large ribosomal subunit rRNA binding
AN947_08010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AN947_08015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AN947_08025	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AN947_08035	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AN947_08040	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AN947_08045	COG0723	plastoquinol--plastocyanin reductase activity
AN947_08050	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AN947_08055	COG2857	Cytochrome c1
AN947_08060	COG0625	glutathione transferase activity
AN947_08065	COG2969	positive regulation of protein catabolic process
AN947_08070	COG2823	Periplasmic or secreted lipoprotein
AN947_08075	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AN947_08080	COG0792	nuclease activity
AN947_08085	COG3107	peptidoglycan biosynthetic process
AN947_08090	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AN947_08110	COG0659	secondary active sulfate transmembrane transporter activity
AN947_08115	COG1131	(ABC) transporter
AN947_08120	COG0842	Transport permease protein
AN947_08125	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AN947_08130	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AN947_08135	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AN947_08145	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AN947_08150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AN947_08165	COG1643	Atp-dependent helicase
AN947_08175	COG1752	Esterase of the alpha-beta hydrolase superfamily
AN947_08185	COG3112	Uncharacterised protein family (UPF0231)
AN947_08190	COG0347	Belongs to the P(II) protein family
AN947_08195	COG0004	ammonium transporteR
AN947_08200	COG1840	ABC-type Fe3 transport system, periplasmic component
AN947_08210	COG3842	ATPase activity
AN947_08230	COG2971	BadF BadG BcrA BcrD
AN947_08240	COG4608	Belongs to the ABC transporter superfamily
AN947_08245	COG0444	Belongs to the ABC transporter superfamily
AN947_08250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AN947_08255	COG0601	transmembrane transport
AN947_08260	COG0747	negative chemotaxis
AN947_08275	COG2813	Specifically methylates the guanine in position
AN947_08280	COG0628	permease
AN947_08290	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AN947_08300	COG0316	Belongs to the HesB IscA family
AN947_08315	COG0739	heme binding
AN947_08320	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AN947_08325	COG2027	D-alanyl-D-alanine carboxypeptidase
AN947_08330	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AN947_08335	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AN947_08340	COG1534	Rna-binding protein
AN947_08345	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AN947_08350	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AN947_08355	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AN947_08360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AN947_08365	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AN947_08380	COG0779	Required for maturation of 30S ribosomal subunits
AN947_08385	COG0195	Participates in both transcription termination and antitermination
AN947_08390	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AN947_08395	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AN947_08400	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AN947_08405	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AN947_08410	COG1185	polyribonucleotide nucleotidyltransferase activity
AN947_08415	COG4785	May be involved in cell division
AN947_08450	COG3153	acetyltransferase
AN947_08515	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AN947_08580	COG1196	nuclear chromosome segregation
AN947_08610	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
AN947_08655	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AN947_08670	COG0681	Belongs to the peptidase S26 family
AN947_08705	COG2356	endonuclease I
AN947_08720	COG0629	single-stranded DNA binding
AN947_08735	COG0714	Associated with various cellular activities
AN947_08760	COG2003	Belongs to the UPF0758 family
AN947_08780	COG0745	RESPONSE REGULATOR receiver
AN947_08780	COG3706	GGDEF domain
AN947_08785	COG4999	Histidine kinase
AN947_08785	COG2205	protein histidine kinase activity
AN947_08785	COG3850	Histidine kinase
AN947_08785	COG3437	response regulator, receiver
AN947_08845	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AN947_08850	COG0513	Belongs to the DEAD box helicase family
AN947_08855	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AN947_08865	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AN947_08870	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AN947_08875	COG2204	response regulator
AN947_08885	COG0667	Aldo Keto reductase
AN947_08890	COG3066	DNA modification
AN947_08900	COG0494	nUDIX hydrolase
AN947_08905	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
AN947_08910	COG0730	response to heat
AN947_08915	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AN947_08920	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AN947_08925	COG1283	sodium-dependent phosphate transmembrane transporter activity
AN947_08930	COG0583	DNA-binding transcription factor activity
AN947_08935	COG0640	Transcriptional regulator
AN947_08940	COG0268	Binds directly to 16S ribosomal RNA
AN947_08950	COG0196	riboflavin kinase activity
AN947_08955	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AN947_08960	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AN947_08965	COG1047	Peptidyl-prolyl cis-trans
AN947_08970	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AN947_08975	COG1966	Carbon starvation protein
AN947_08990	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AN947_08995	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AN947_09000	COG1472	Belongs to the glycosyl hydrolase 3 family
AN947_09005	COG3279	Response regulator of the LytR AlgR family
AN947_09010	COG3275	phosphorelay sensor kinase activity
AN947_09015	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AN947_09020	COG0287	Prephenate dehydrogenase
AN947_09020	COG1605	Chorismate mutase
AN947_09030	COG0488	(ABC) transporter
AN947_09040	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
AN947_09045	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AN947_09050	COG5001	Diguanylate cyclase
AN947_09055	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AN947_09060	COG0077	Prephenate dehydratase
AN947_09060	COG1605	Chorismate mutase
AN947_09065	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AN947_09070	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AN947_09075	COG0564	pseudouridine synthase activity
AN947_09085	COG0542	response to heat
AN947_09130	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AN947_09140	COG2974	May be involved in recombination
AN947_09145	COG0745	RESPONSE REGULATOR receiver
AN947_09150	COG5002	protein histidine kinase activity
AN947_09160	COG0248	Ppx GppA phosphatase
AN947_09165	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AN947_09175	COG0581	inorganic phosphate transmembrane transporter activity
AN947_09180	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AN947_09200	COG0450	alkyl hydroperoxide reductase
AN947_09205	COG0583	DNA-binding transcription factor activity
AN947_09220	COG0517	IMP dehydrogenase activity
AN947_09225	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AN947_09235	COG0343	queuine tRNA-ribosyltransferase activity
AN947_09240	COG1862	Preprotein translocase
AN947_09245	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AN947_09250	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AN947_09255	COG0483	inositol monophosphate 1-phosphatase activity
AN947_09265	COG1959	2 iron, 2 sulfur cluster binding
AN947_09270	COG1104	cysteine desulfurase activity
AN947_09275	COG0822	iron-sulfur transferase activity
AN947_09285	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AN947_09290	COG0443	Heat shock 70 kDa protein
AN947_09295	COG0633	Ferredoxin
AN947_09300	COG2975	iron-sulfur cluster assembly
AN947_09305	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AN947_09310	COG0105	UTP biosynthetic process
AN947_09315	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AN947_09325	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AN947_09330	COG0124	histidyl-tRNA synthetase
AN947_09335	COG2976	Protein conserved in bacteria
AN947_09340	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AN947_09345	COG1160	GTP binding
AN947_09360	COG1570	exodeoxyribonuclease VII activity
AN947_09365	COG0517	IMP dehydrogenase activity
AN947_09365	COG0516	GMP reductase activity
AN947_09370	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AN947_09370	COG0519	Catalyzes the synthesis of GMP from XMP
AN947_09380	COG1584	GPR1 FUN34 yaaH family protein
AN947_09385	COG3433	isochorismatase activity
AN947_09385	COG1535	isochorismatase
AN947_09390	COG1021	2,3-dihydroxybenzoate-AMP ligase
AN947_09395	COG1169	isochorismate synthase
AN947_09400	COG1028	Short-chain dehydrogenase reductase Sdr
AN947_09410	COG4592	Periplasmic binding protein
AN947_09415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN947_09420	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN947_09425	COG1120	ATPase activity
AN947_09435	COG0583	DNA-binding transcription factor activity
AN947_09440	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AN947_09445	COG1115	amino acid carrier protein
AN947_09450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AN947_09455	COG0583	DNA-binding transcription factor activity
AN947_09470	COG4565	transcriptional regulatory protein
AN947_09480	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AN947_09485	COG0511	ligase activity, forming carbon-carbon bonds
AN947_09485	COG5016	pyruvate
AN947_09490	COG3630	sodium ion export across plasma membrane
AN947_09500	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
AN947_09505	COG3052	prosthetic group binding
AN947_09510	COG2301	Belongs to the HpcH HpaI aldolase family
AN947_09515	COG3051	citrate lyase alpha subunit
AN947_09520	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
AN947_09525	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AN947_09535	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AN947_09540	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AN947_09545	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AN947_09615	COG1012	belongs to the aldehyde dehydrogenase family
AN947_09635	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AN947_09640	COG0840	transmembrane signaling receptor activity
AN947_09645	COG3710	Transcriptional regulator
AN947_09655	COG2165	general secretion pathway protein
AN947_09670	COG4796	Type ii and iii secretion system protein
AN947_09690	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AN947_09695	COG1459	type II secretion system
AN947_09705	COG2207	Transcriptional regulator
AN947_09710	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AN947_09730	COG0739	heme binding
AN947_09740	COG3064	Membrane
AN947_09750	COG0582	viral genome integration into host DNA
AN947_09755	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AN947_09760	COG2867	negative regulation of translational initiation
AN947_09765	COG2914	Belongs to the UPF0125 (RnfH) family
AN947_09770	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AN947_09775	COG0497	DNA recombination
AN947_09780	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AN947_09785	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AN947_09790	COG0443	Heat shock 70 kDa protein
AN947_09795	COG0484	heat shock protein binding
AN947_09830	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AN947_09835	COG0590	tRNA wobble adenosine to inosine editing
AN947_09845	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AN947_09855	COG0047	phosphoribosylformylglycinamidine synthase activity
AN947_09855	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AN947_09860	COG1943	Transposase
AN947_09885	COG0442	prolyl-tRNA aminoacylation
AN947_09890	COG1720	tRNA m6t6A37 methyltransferase activity
AN947_09895	COG0254	rRNA binding
AN947_09900	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AN947_09905	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AN947_09910	COG1671	Belongs to the UPF0178 family
AN947_09920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AN947_09935	COG3098	single-species biofilm formation
AN947_09940	COG0564	pseudouridine synthase activity
AN947_09945	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AN947_09950	COG0142	geranyltranstransferase activity
AN947_09955	COG1722	exodeoxyribonuclease VII activity
AN947_09960	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AN947_09970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AN947_09970	COG0301	tRNA thio-modification
AN947_09980	COG0583	DNA-binding transcription factor activity
AN947_09985	COG2363	Small membrane protein
AN947_09990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AN947_09995	COG1611	Belongs to the LOG family
AN947_10000	COG3706	GGDEF domain
AN947_10010	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AN947_10010	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AN947_10020	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
AN947_10025	COG1464	Belongs to the NlpA lipoprotein family
AN947_10030	COG2011	ABC-type metal ion transport system permease component
AN947_10035	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AN947_10040	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AN947_10045	COG1609	Transcriptional regulator
AN947_10050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AN947_10050	COG1263	PTS System
AN947_10055	COG0366	Alpha amylase catalytic
AN947_10090	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AN947_10095	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AN947_10100	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AN947_10105	COG0110	maltose O-acetyltransferase activity
AN947_10125	COG1045	serine acetyltransferase
AN947_10135	COG0438	transferase activity, transferring glycosyl groups
AN947_10145	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AN947_10175	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AN947_10185	COG1596	polysaccharide export
AN947_10210	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AN947_10225	COG0321	lipoyl(octanoyl) transferase activity
AN947_10230	COG2921	Belongs to the UPF0250 family
AN947_10240	COG1686	Belongs to the peptidase S11 family
AN947_10245	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AN947_10250	COG0772	Belongs to the SEDS family
AN947_10255	COG0768	penicillin binding
AN947_10260	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AN947_10265	COG0799	negative regulation of ribosome biogenesis
AN947_10270	COG1466	dna polymerase III delta subunit
AN947_10275	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
AN947_10280	COG0495	leucyl-tRNA aminoacylation
AN947_10285	COG2888	peptidyl-tyrosine sulfation
AN947_10290	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AN947_10295	COG4535	Mg2 and Co2 transporter CorC
AN947_10300	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AN947_10305	COG1702	phosphate starvation-inducible protein PhoH
AN947_10310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AN947_10315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AN947_10320	COG2190	(PTS) system
AN947_10330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AN947_10340	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AN947_10345	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AN947_10350	COG3115	cell septum assembly
AN947_10355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AN947_10370	COG0789	Transcriptional regulator
AN947_10375	COG1585	Membrane protein implicated in regulation of membrane protease activity
AN947_10380	COG0330	HflC and HflK could
AN947_10385	COG3118	belongs to the thioredoxin family
AN947_10390	COG0300	oxidoreductase activity
AN947_10395	COG1090	epimerase
AN947_10400	COG0622	Phosphoesterase
AN947_10415	COG3710	Transcriptional regulator
AN947_10420	COG0326	Molecular chaperone. Has ATPase activity
AN947_10425	COG0563	adenylate kinase activity
AN947_10430	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AN947_10445	COG0367	asparagine synthase
AN947_10450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AN947_10450	COG4651	solute:proton antiporter activity
AN947_10455	COG1940	carbohydrate kinase activity
AN947_10455	COG1846	Transcriptional regulator
AN947_10465	COG2190	(PTS) system
AN947_10465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AN947_10465	COG1263	PTS System
AN947_10480	COG0101	tRNA pseudouridine synthase activity
AN947_10485	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AN947_10490	COG0285	dihydrofolate synthase activity
AN947_10495	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AN947_10500	COG1286	toxin biosynthetic process
AN947_10505	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AN947_10510	COG2056	Na+-H+ antiporter family
AN947_10515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AN947_10535	COG0346	lactoylglutathione lyase activity
AN947_10540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AN947_10545	COG4660	Part of a membrane complex involved in electron transport
AN947_10550	COG4659	FMN binding
AN947_10555	COG4658	electron transport chain
AN947_10560	COG4656	Part of a membrane complex involved in electron transport
AN947_10565	COG2878	Part of a membrane complex involved in electron transport
AN947_10570	COG4657	Part of a membrane complex involved in electron transport
AN947_10580	COG0556	nucleotide-excision repair
AN947_10590	COG2204	response regulator
AN947_10595	COG2198	Histidine kinase
AN947_10600	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AN947_10605	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AN947_10610	COG0521	Mo-molybdopterin cofactor biosynthetic process
AN947_10615	COG0315	cyclic pyranopterin monophosphate synthase activity
AN947_10620	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AN947_10625	COG0314	molybdopterin synthase activity
AN947_10630	COG2199	diguanylate cyclase activity
AN947_10635	COG4109	DRTGG domain
AN947_10650	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AN947_10660	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AN947_10660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AN947_10665	COG0489	protein tyrosine kinase activity
AN947_10675	COG0572	uridine kinase
AN947_10680	COG2982	Protein involved in outer membrane biogenesis
AN947_10685	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AN947_10690	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AN947_10720	COG0183	Belongs to the thiolase family
AN947_10725	COG1250	3-hydroxyacyl-CoA dehydrogenase
AN947_10725	COG1024	Enoyl-CoA hydratase
AN947_10730	COG0778	Nitroreductase
AN947_10735	COG0583	DNA-binding transcription factor activity
AN947_10740	COG0745	RESPONSE REGULATOR receiver
AN947_10750	COG2832	Protein of unknown function (DUF454)
AN947_10755	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AN947_10765	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AN947_10770	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AN947_10785	COG1028	Short-chain dehydrogenase reductase Sdr
AN947_10790	COG0616	signal peptide processing
AN947_10800	COG1522	sequence-specific DNA binding
AN947_10805	COG1946	Acyl-CoA thioesterase
AN947_10825	COG3706	GGDEF domain
AN947_10830	COG0640	Transcriptional regulator
AN947_10835	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AN947_10860	COG1881	PFAM PEBP family protein
AN947_10880	COG0009	L-threonylcarbamoyladenylate synthase
AN947_10895	COG2201	protein-glutamate methylesterase activity
AN947_10905	COG5002	protein histidine kinase activity
AN947_10910	COG4191	Histidine kinase
AN947_10915	COG5001	Diguanylate cyclase
AN947_10915	COG3300	MHYT domain
AN947_10920	COG2204	response regulator
AN947_10940	COG0601	transmembrane transport
AN947_10945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AN947_10950	COG0444	Belongs to the ABC transporter superfamily
AN947_10955	COG4608	Belongs to the ABC transporter superfamily
AN947_10960	COG0435	Glutathione S-transferase
AN947_10965	COG0857	belongs to the CobB CobQ family
AN947_10965	COG0280	phosphate acetyltransferase
AN947_10970	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AN947_10975	COG3092	negative regulation of chromosome organization
AN947_10980	COG4628	conserved protein (DUF2132)
AN947_10990	COG4120	Belongs to the binding-protein-dependent transport system permease family
AN947_11000	COG2203	Gaf domain
AN947_11000	COG2199	diguanylate cyclase activity
AN947_11005	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AN947_11015	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AN947_11020	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AN947_11025	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AN947_11035	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AN947_11040	COG0156	8-amino-7-oxononanoate synthase activity
AN947_11045	COG2226	methyltransferase
AN947_11050	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AN947_11085	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AN947_11095	COG2268	Band 7 protein
AN947_11105	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AN947_11110	COG2915	High frequency lysogenization protein hflD homolog
AN947_11120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AN947_11125	COG2916	Histone family protein nucleoid-structuring protein H-NS
AN947_11130	COG1757	Na H antiporter
AN947_11135	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AN947_11140	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AN947_11145	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AN947_11150	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AN947_11150	COG0131	Imidazoleglycerol-phosphate dehydratase
AN947_11155	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AN947_11160	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AN947_11165	COG0107	imidazoleglycerol-phosphate synthase activity
AN947_11170	COG0140	phosphoribosyl-ATP diphosphatase activity
AN947_11170	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AN947_11175	COG1187	pseudouridine synthase activity
AN947_11185	COG1278	Cold shock
AN947_11190	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AN947_11195	COG0542	response to heat
AN947_11205	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AN947_11210	COG1012	belongs to the aldehyde dehydrogenase family
AN947_11210	COG1454	alcohol dehydrogenase
AN947_11215	COG1737	Transcriptional regulator
AN947_11220	COG0076	glutamate decarboxylase activity
AN947_11230	COG2431	L-lysine efflux transmembrane transporter activity
AN947_11240	COG3070	regulator of competence-specific genes
AN947_11255	COG3852	Histidine kinase
AN947_11265	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AN947_11280	COG0189	ligase activity
AN947_11280	COG4067	protein conserved in archaea
AN947_11285	COG0500	methyltransferase
AN947_11290	COG4106	trans-aconitate 2-methyltransferase activity
AN947_11295	COG1801	Protein of unknown function DUF72
AN947_11300	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AN947_11305	COG1435	thymidine kinase activity
AN947_11315	COG0159	tryptophan synthase activity
AN947_11320	COG0133	tryptophan synthase activity
AN947_11325	COG0134	indole-3-glycerol-phosphate synthase activity
AN947_11325	COG0135	phosphoribosylanthranilate isomerase activity
AN947_11330	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AN947_11335	COG0512	Glutamine amidotransferase of anthranilate synthase
AN947_11340	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AN947_11350	COG0613	PHP domain protein
AN947_11355	COG0009	L-threonylcarbamoyladenylate synthase
AN947_11360	COG1187	pseudouridine synthase activity
AN947_11365	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AN947_11370	COG4988	ABC transporter
AN947_11375	COG0492	ferredoxin-NADP+ reductase activity
AN947_11385	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AN947_11390	COG3706	GGDEF domain
AN947_11395	COG2949	membrane
AN947_11405	COG0281	malic enzyme
AN947_11415	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AN947_11435	COG2885	chlorophyll binding
AN947_11450	COG0277	FAD linked oxidase domain protein
AN947_11450	COG0247	lactate metabolic process
AN947_11470	COG2986	histidine ammonia-lyase
AN947_11475	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AN947_11480	COG0010	Belongs to the arginase family
AN947_11485	COG1228	amidohydrolase
AN947_11505	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AN947_11515	COG5001	Diguanylate cyclase
AN947_11520	COG0417	DNA replication proofreading
AN947_11525	COG2197	response regulator
AN947_11530	COG0322	excinuclease ABC activity
AN947_11560	COG3706	GGDEF domain
AN947_11560	COG0745	RESPONSE REGULATOR receiver
AN947_11570	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AN947_11575	COG0072	phenylalanine-tRNA ligase activity
AN947_11575	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AN947_11595	COG0500	methyltransferase
AN947_11605	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AN947_11615	COG0295	cytidine deaminase activity
AN947_11620	COG1346	cytolysis
AN947_11630	COG2925	Exonuclease
AN947_11640	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AN947_11645	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AN947_11650	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AN947_11665	COG2988	succinylglutamate desuccinylase activity
AN947_11670	COG4139	cobalamin transport
AN947_11675	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
AN947_11720	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AN947_11725	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AN947_11730	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AN947_11750	COG2814	Major facilitator Superfamily
AN947_11760	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AN947_11785	COG2989	Protein conserved in bacteria
AN947_11790	COG3108	Peptidase M15
AN947_11795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AN947_11810	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AN947_11835	COG1846	Transcriptional regulator
AN947_11840	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AN947_11845	COG0726	polysaccharide deacetylase
AN947_11850	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AN947_11860	COG1447	Phosphotransferase system cellobiose-specific component IIA
AN947_11865	COG1486	melibiose metabolic process
AN947_11870	COG3394	polysaccharide catabolic process
AN947_11875	COG1609	Transcriptional regulator
AN947_11880	COG2943	transferase activity, transferring hexosyl groups
AN947_11885	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AN947_11890	COG0840	transmembrane signaling receptor activity
AN947_11905	COG1448	Aminotransferase
AN947_11915	COG3437	response regulator, receiver
AN947_11915	COG2770	Histidine kinase
AN947_11920	COG0351	phosphomethylpyrimidine kinase
AN947_11925	COG0017	Asparaginyl-tRNA synthetase
AN947_11935	COG0720	synthase
AN947_11940	COG1760	l-serine dehydratase
AN947_11945	COG0814	amino acid
AN947_11950	COG0494	nUDIX hydrolase
AN947_11955	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AN947_11970	COG3106	COG3106 Predicted ATPase
AN947_11975	COG3768	UPF0283 membrane protein
AN947_11980	COG3283	Transcriptional regulator of aromatic amino acids metabolism
AN947_11985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AN947_12000	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AN947_12010	COG0471	metal ion transport
AN947_12015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AN947_12015	COG4191	Histidine kinase
AN947_12025	COG2990	Protein conserved in bacteria
AN947_12035	COG2205	protein histidine kinase activity
AN947_12040	COG0745	RESPONSE REGULATOR receiver
AN947_12110	COG2186	Transcriptional regulator
AN947_12115	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AN947_12120	COG0372	Belongs to the citrate synthase family
AN947_12150	COG2195	Cleaves the N-terminal amino acid of tripeptides
AN947_12160	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AN947_12170	COG0625	glutathione transferase activity
AN947_12175	COG3437	response regulator, receiver
AN947_12200	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AN947_12205	COG1254	Belongs to the acylphosphatase family
AN947_12210	COG2920	part of a sulfur-relay system
AN947_12215	COG0670	Belongs to the BI1 family
AN947_12220	COG1126	abc transporter atp-binding protein
AN947_12225	COG0765	amino acid transport
AN947_12230	COG4597	amino acid ABC transporter
AN947_12235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AN947_12245	COG0561	phosphatase activity
AN947_12250	COG0602	queuosine metabolic process
AN947_12255	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AN947_12285	COG3706	GGDEF domain
AN947_12290	COG0443	Heat shock 70 kDa protein
AN947_12295	COG0443	Heat shock 70 kDa protein
AN947_12335	COG1643	Atp-dependent helicase
AN947_12345	COG0443	Heat shock 70 kDa protein
AN947_12350	COG0095	Lipoate-protein ligase
AN947_12360	COG0583	DNA-binding transcription factor activity
AN947_12365	COG0477	Major facilitator Superfamily
AN947_12370	COG0415	Belongs to the DNA photolyase family
AN947_12375	COG2076	Multidrug Resistance protein
AN947_12405	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AN947_12415	COG2201	protein-glutamate methylesterase activity
AN947_12420	COG0835	chemotaxis
AN947_12425	COG3290	protein histidine kinase activity
AN947_12425	COG0840	transmembrane signaling receptor activity
AN947_12430	COG0840	transmembrane signaling receptor activity
AN947_12440	COG0513	Belongs to the DEAD box helicase family
AN947_12450	COG1538	Outer membrane efflux protein
AN947_12455	COG1566	PFAM secretion protein HlyD family protein
AN947_12460	COG2814	Major facilitator Superfamily
AN947_12465	COG0840	transmembrane signaling receptor activity
AN947_12470	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AN947_12480	COG3501	Rhs element vgr protein
AN947_12505	COG1280	lysine exporter protein (LysE YggA)
AN947_12510	COG1115	amino acid carrier protein
AN947_12525	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AN947_12530	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AN947_12535	COG1177	transmembrane transport
AN947_12540	COG1176	ABC-type spermidine putrescine transport system, permease component I
AN947_12545	COG3842	ATPase activity
AN947_12565	COG0037	tRNA processing
AN947_12570	COG0589	response to stress
AN947_12575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AN947_12590	COG2217	Heavy metal translocating P-type atpase
AN947_12600	COG2010	Cytochrome c
AN947_12615	COG3278	Belongs to the heme-copper respiratory oxidase family
AN947_12630	COG0784	Response regulator, receiver
AN947_12630	COG2205	protein histidine kinase activity
AN947_12655	COG2994	toxin metabolic process
AN947_12660	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AN947_12660	COG3064	Membrane
AN947_12660	COG1073	alpha beta
AN947_12665	COG4128	Pfam Zonular occludens toxin
AN947_12705	COG4128	Pfam Zonular occludens toxin
AN947_12735	COG1476	TRANSCRIPTIONal
AN947_12750	COG4128	Pfam Zonular occludens toxin
AN947_12865	COG3120	sequence-specific DNA binding
AN947_12870	COG1067	ATP-dependent peptidase activity
AN947_12875	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AN947_12900	COG0116	Belongs to the methyltransferase superfamily
AN947_12900	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AN947_12910	COG0167	dihydroorotate dehydrogenase activity
AN947_12925	COG0308	aminopeptidase N
AN947_12945	COG1956	GAF domain-containing protein
AN947_12950	COG1132	(ABC) transporter
AN947_12955	COG2995	paraquat-inducible protein a
AN947_12960	COG3008	intermembrane lipid transfer
AN947_12965	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AN947_12965	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AN947_12970	COG2996	Protein conserved in bacteria
AN947_12985	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AN947_12995	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AN947_13010	COG0437	4 iron, 4 sulfur cluster binding
AN947_13015	COG3383	formate dehydrogenase (NAD+) activity
AN947_13015	COG0243	molybdopterin cofactor binding
AN947_13045	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AN947_13050	COG0488	(ABC) transporter
AN947_13055	COG3852	Histidine kinase
AN947_13060	COG2204	response regulator
AN947_13070	COG4662	Binding-protein-dependent transport system inner membrane component
AN947_13075	COG3842	ATPase activity
AN947_13080	COG0746	molybdenum cofactor guanylyltransferase activity
AN947_13110	COG1940	carbohydrate kinase activity
AN947_13125	COG0840	transmembrane signaling receptor activity
AN947_13130	COG0791	NLP P60 protein
AN947_13150	COG0534	Mate efflux family protein
AN947_13160	COG1793	dna ligase
AN947_13170	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AN947_13175	COG0848	biopolymer transport protein
AN947_13180	COG0811	peptide transport
AN947_13185	COG0811	peptide transport
AN947_13200	COG1175	transmembrane transport
AN947_13205	COG0395	ABC-type sugar transport system, permease component
AN947_13215	COG1349	DNA-binding transcription factor activity
AN947_13220	COG0584	glycerophosphoryl diester phosphodiesterase
AN947_13225	COG2731	YhcH YjgK YiaL family protein
AN947_13230	COG0251	oxidation-reduction process
AN947_13235	COG1609	Transcriptional regulator
AN947_13240	COG2723	6-phospho-beta-galactosidase activity
AN947_13250	COG0583	DNA-binding transcription factor activity
AN947_13270	COG0577	efflux transmembrane transporter activity
AN947_13270	COG1136	(ABC) transporter
AN947_13275	COG0577	efflux transmembrane transporter activity
AN947_13275	COG1136	(ABC) transporter
AN947_13280	COG1136	(ABC) transporter
AN947_13280	COG4591	ABC-type transport system involved in lipoprotein release permease component
AN947_13285	COG1294	oxidase, subunit
AN947_13290	COG1271	oxidase subunit
AN947_13330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AN947_13340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AN947_13360	COG0753	catalase activity
AN947_13375	COG3527	Alpha-acetolactate decarboxylase
AN947_13390	COG2200	EAL domain
AN947_13390	COG2199	diguanylate cyclase activity
AN947_13395	COG3706	GGDEF domain
AN947_13405	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AN947_13410	COG1085	galactose-1-phosphate uridylyltransferase
AN947_13460	COG4565	transcriptional regulatory protein
AN947_13465	COG3290	protein histidine kinase activity
AN947_13480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AN947_13500	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AN947_13505	COG3063	Type IV pilus biogenesis stability protein PilW
AN947_13520	COG1451	nucleotide metabolic process
AN947_13530	COG0583	DNA-binding transcription factor activity
AN947_13560	COG0019	diaminopimelate decarboxylase activity
AN947_13565	COG1748	Saccharopine dehydrogenase
AN947_13575	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AN947_13595	COG0534	Mate efflux family protein
AN947_13610	COG2814	Major facilitator Superfamily
AN947_13615	COG1187	pseudouridine synthase activity
AN947_13620	COG1061	Type III restriction enzyme res subunit
AN947_13640	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AN947_13645	COG3706	GGDEF domain
AN947_13645	COG4251	negative regulation of phosphorylation
AN947_13645	COG2203	Gaf domain
AN947_13645	COG5001	Diguanylate cyclase
AN947_13660	COG0840	transmembrane signaling receptor activity
AN947_13690	COG4934	collagen metabolic process
AN947_13710	COG2239	Acts as a magnesium transporter
AN947_13720	COG0814	amino acid
AN947_13725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AN947_13730	COG1131	(ABC) transporter
AN947_13735	COG0842	Transport permease protein
AN947_13745	COG3313	Fe-S protein
AN947_13755	COG4134	Bacterial extracellular solute-binding protein
AN947_13760	COG4135	transport system, permease component
AN947_13765	COG4136	ATPase activity
AN947_13775	COG0564	pseudouridine synthase activity
AN947_13780	COG0733	neurotransmitter:sodium symporter activity
AN947_13790	COG0626	cystathionine gamma-synthase activity
AN947_13795	COG2818	Glycosylase
AN947_13810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AN947_13825	COG1842	Phage shock protein A
AN947_13830	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AN947_13840	COG4168	peptide transport system, permease
AN947_13845	COG4171	peptide transport system, permease
AN947_13855	COG4172	Belongs to the ABC transporter superfamily
AN947_13870	COG1227	inorganic diphosphatase activity
AN947_13890	COG0243	molybdopterin cofactor binding
AN947_13895	COG3005	denitrification pathway
AN947_13900	COG4459	periplasmic nitrate reductase
AN947_13910	COG2116	formate transmembrane transporter activity
AN947_13920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AN947_13925	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AN947_13935	COG2917	probably involved in intracellular septation
AN947_13945	COG2350	Protein conserved in bacteria
AN947_13955	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AN947_13960	COG0583	DNA-binding transcription factor activity
AN947_13975	COG0612	Peptidase, M16
AN947_13985	COG1032	radical SAM domain protein
AN947_14000	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AN947_14005	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AN947_14010	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
AN947_14015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AN947_14020	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AN947_14025	COG0745	RESPONSE REGULATOR receiver
AN947_14030	COG3381	protein complex oligomerization
AN947_14035	COG1609	Transcriptional regulator
AN947_14040	COG3070	regulator of competence-specific genes
AN947_14060	COG0297	glycogen (starch) synthase activity
AN947_14065	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AN947_14070	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AN947_14080	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AN947_14090	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AN947_14100	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AN947_14105	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AN947_14135	COG1309	transcriptional regulator
AN947_14160	COG0668	transmembrane transport
AN947_14170	COG3008	intermembrane lipid transfer
AN947_14170	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AN947_14180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AN947_14195	COG0582	viral genome integration into host DNA
AN947_14220	COG3941	tape measure
AN947_14260	COG0488	(ABC) transporter
AN947_14335	COG0415	Belongs to the DNA photolyase family
AN947_14345	COG4628	conserved protein (DUF2132)
AN947_14350	COG3284	Transcriptional regulator
AN947_14355	COG1012	belongs to the aldehyde dehydrogenase family
AN947_14365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AN947_14370	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AN947_14375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AN947_14385	COG2207	Transcriptional regulator
AN947_14390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AN947_14390	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AN947_14390	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AN947_14395	COG1482	cell wall glycoprotein biosynthetic process
AN947_14405	COG5002	protein histidine kinase activity
AN947_14405	COG0784	Response regulator, receiver
AN947_14415	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AN947_14425	COG2885	chlorophyll binding
AN947_14430	COG0823	Involved in the tonB-independent uptake of proteins
AN947_14445	COG0811	peptide transport
AN947_14450	COG0824	Thioesterase
AN947_14455	COG3790	cyd operon protein YbgE
AN947_14460	COG4890	Cyd operon protein YbgT
AN947_14465	COG1294	oxidase, subunit
AN947_14470	COG1271	oxidase subunit
AN947_14475	COG2255	four-way junction helicase activity
AN947_14480	COG0632	four-way junction helicase activity
AN947_14485	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AN947_14490	COG0215	cysteine-tRNA ligase activity
AN947_14495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AN947_14500	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AN947_14505	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AN947_14515	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AN947_14520	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AN947_14525	COG1199	ATP-dependent helicase activity
AN947_14530	COG0730	response to heat
AN947_14535	COG3923	Primosomal replication protein n
AN947_14545	COG0840	transmembrane signaling receptor activity
AN947_14550	COG0708	Exodeoxyribonuclease III
AN947_14555	COG4160	amino acid transport
AN947_14560	COG4215	(ABC) transporter
AN947_14580	COG1882	Formate acetyltransferase
AN947_14590	COG0840	transmembrane signaling receptor activity
AN947_14595	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AN947_14605	COG3013	Belongs to the UPF0304 family
AN947_14610	COG2766	serine protein kinase
AN947_14615	COG2718	Belongs to the UPF0229 family
AN947_14620	COG2719	SpoVR family
AN947_14625	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AN947_14635	COG1663	tetraacyldisaccharide 4'-kinase activity
AN947_14640	COG1132	(ABC) transporter
AN947_14645	COG0658	competence protein
AN947_14645	COG2333	competence protein COMEC
AN947_14655	COG4591	ABC-type transport system involved in lipoprotein release permease component
AN947_14660	COG1136	(ABC) transporter
AN947_14665	COG4591	ABC-type transport system involved in lipoprotein release permease component
AN947_14675	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AN947_14695	COG1252	NADH dehydrogenase
AN947_14725	COG0537	adenosine 5'-monophosphoramidase activity
AN947_14740	COG2186	Transcriptional regulator
AN947_14745	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AN947_14750	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AN947_14755	COG1674	ftsk spoiiie
AN947_14765	COG0686	Belongs to the AlaDH PNT family
AN947_14775	COG0583	DNA-binding transcription factor activity
AN947_14790	COG0284	orotidine-5'-phosphate decarboxylase activity
AN947_14795	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AN947_14800	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AN947_14805	COG0776	regulation of translation
AN947_14810	COG0539	negative regulation of cytoplasmic translation
AN947_14815	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AN947_14820	COG1555	photosystem II stabilization
AN947_14825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AN947_14830	COG0776	regulation of translation
AN947_14835	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AN947_14840	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AN947_14850	COG0544	peptidyl-prolyl cis-trans isomerase activity
AN947_14870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AN947_14875	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AN947_14880	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AN947_14885	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AN947_14900	COG3300	MHYT domain
AN947_14900	COG5001	Diguanylate cyclase
AN947_14910	COG4589	Belongs to the CDS family
AN947_14945	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AN947_14955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AN947_14970	COG0243	molybdopterin cofactor binding
AN947_14975	COG3005	denitrification pathway
AN947_14980	COG3325	Belongs to the glycosyl hydrolase 18 family
AN947_14980	COG3469	chitinase activity
AN947_14985	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AN947_14995	COG2951	lytic endotransglycosylase activity
AN947_15000	COG3100	YcgL domain-containing protein
AN947_15005	COG0850	regulation of cytokinetic process
AN947_15010	COG2894	cell division
AN947_15015	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AN947_15020	COG3015	lipoprotein NlpE involved in copper resistance
AN947_15050	COG0840	transmembrane signaling receptor activity
AN947_15055	COG1396	sequence-specific DNA binding
AN947_15060	COG3135	benzoate transporter
AN947_15070	COG1441	menaquinone biosynthetic process
AN947_15080	COG0596	Alpha beta hydrolase
AN947_15085	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AN947_15090	COG1169	isochorismate synthase
AN947_15095	COG0436	Aminotransferase
AN947_15100	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AN947_15105	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AN947_15125	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AN947_15130	COG0318	PFAM AMP-dependent synthetase and ligase
AN947_15135	COG0596	Alpha beta hydrolase
AN947_15150	COG1214	PFAM Peptidase M22, glycoprotease
AN947_15155	COG1199	ATP-dependent helicase activity
AN947_15165	COG0788	formyltetrahydrofolate deformylase activity
AN947_15170	COG0446	pyridine nucleotide-disulphide oxidoreductase
AN947_15170	COG1902	pentaerythritol trinitrate reductase activity
AN947_15175	COG0616	signal peptide processing
AN947_15180	COG0252	asparaginase activity
AN947_15185	COG3139	Protein of unknown function (DUF1315)
AN947_15195	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AN947_15200	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AN947_15215	COG2226	methyltransferase
AN947_15230	COG0784	Response regulator, receiver
AN947_15230	COG0835	chemotaxis
AN947_15235	COG1940	carbohydrate kinase activity
AN947_15255	COG0733	neurotransmitter:sodium symporter activity
AN947_15260	COG1263	PTS System
AN947_15260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AN947_15265	COG0084	hydrolase, TatD family'
AN947_15275	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AN947_15280	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AN947_15285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AN947_15290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AN947_15295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AN947_15300	COG1028	Short-chain dehydrogenase reductase Sdr
AN947_15305	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AN947_15310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AN947_15315	COG0416	fatty acid biosynthetic process
AN947_15320	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AN947_15325	COG1399	metal-binding, possibly nucleic acid-binding protein
AN947_15330	COG0424	maF-like protein
AN947_15335	COG0564	pseudouridine synthase activity
AN947_15350	COG1530	ribonuclease E activity
AN947_15365	COG1454	alcohol dehydrogenase
AN947_15365	COG1012	belongs to the aldehyde dehydrogenase family
AN947_15370	COG2095	MarC family integral membrane protein
AN947_15375	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AN947_15380	COG1757	Na H antiporter
AN947_15390	COG3081	Nucleoid-associated protein
AN947_15400	COG3083	sulfuric ester hydrolase activity
AN947_15415	COG0123	including yeast histone deacetylase and acetoin utilization protein
AN947_15425	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AN947_15445	COG2853	Lipoprotein
AN947_15455	COG3088	subunit of a heme lyase
AN947_15455	COG4235	cytochrome complex assembly
AN947_15460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AN947_15465	COG1138	Cytochrome C-type biogenesis protein
AN947_15470	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AN947_15480	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AN947_15485	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AN947_15490	COG4133	protoheme IX ABC transporter activity
AN947_15500	COG0835	chemotaxis
AN947_15510	COG1192	Involved in chromosome partitioning
AN947_15515	COG2201	protein-glutamate methylesterase activity
AN947_15520	COG2198	Histidine kinase
AN947_15520	COG0643	Histidine kinase
AN947_15525	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AN947_15555	COG2062	phosphohistidine phosphatase, SixA
AN947_15560	COG1025	Belongs to the peptidase M16 family
AN947_15570	COG0018	arginyl-trna synthetase
AN947_15590	COG1918	ferrous iron import across plasma membrane
AN947_15595	COG4977	sequence-specific DNA binding
AN947_15600	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AN947_15605	COG1121	(ABC) transporter
AN947_15610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AN947_15620	COG0045	succinate-CoA ligase (ADP-forming) activity
AN947_15625	COG0508	dehydrogenase complex catalyzes the overall conversion of
AN947_15630	COG0567	Dehydrogenase, E1 component
AN947_15640	COG1053	succinate dehydrogenase
AN947_15645	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AN947_15650	COG2009	succinate dehydrogenase
AN947_15655	COG0372	Belongs to the citrate synthase family
AN947_15660	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AN947_15675	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AN947_15680	COG0596	Alpha beta hydrolase
AN947_15695	COG1346	cytolysis
AN947_15705	COG0583	DNA-binding transcription factor activity
AN947_15715	COG0735	belongs to the Fur family
AN947_15720	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AN947_15725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AN947_15730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AN947_15735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AN947_15735	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AN947_15740	COG0431	NADPH-dependent FMN reductase
AN947_15750	COG3101	peptidyl-lysine hydroxylation
AN947_15755	COG2860	membrane
AN947_15760	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AN947_15770	COG2890	protein-(glutamine-N5) methyltransferase activity
AN947_15785	COG1684	flagellar biosynthetic protein fliR
AN947_15790	COG1987	bacterial-type flagellum assembly
AN947_15815	COG1580	Controls the rotational direction of flagella during chemotaxis
AN947_15835	COG1317	bacterial-type flagellum organization
AN947_15840	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AN947_15850	COG1677	Flagellar hook-basal body complex protein FliE
AN947_15860	COG4191	Histidine kinase
AN947_15865	COG2204	response regulator
AN947_15870	COG1516	flagellar protein fliS
AN947_15880	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AN947_15885	COG1334	flagellar protein FlaG
AN947_15890	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AN947_15895	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AN947_15900	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AN947_15905	COG2837	iron assimilation
AN947_15925	COG1393	Belongs to the ArsC family
AN947_15930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AN947_15935	COG1876	peptidase activity
AN947_15945	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AN947_15950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AN947_15960	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AN947_15980	COG4783	chaperone-mediated protein folding
AN947_15985	COG1393	Belongs to the ArsC family
AN947_16005	COG2233	PERMEase
AN947_16010	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AN947_16015	COG0737	Belongs to the 5'-nucleotidase family
AN947_16020	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AN947_16025	COG2912	Transglutaminase-like superfamily
AN947_16030	COG3094	Invasion gene expression up-regulator, SirB
AN947_16035	COG2890	protein-(glutamine-N5) methyltransferase activity
AN947_16040	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AN947_16045	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AN947_16050	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AN947_16055	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AN947_16060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AN947_16065	COG0193	aminoacyl-tRNA hydrolase activity
AN947_16070	COG0012	GTP binding
AN947_16145	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AN947_16150	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AN947_16170	COG3951	Flagellar rod assembly protein muramidase FlgJ
AN947_16170	COG1705	Flagellar rod assembly protein muramidase FlgJ
AN947_16175	COG1706	bacterial-type flagellum-dependent cell motility
AN947_16180	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AN947_16185	COG4786	Flagellar basal body rod
AN947_16190	COG4787	bacterial-type flagellum-dependent cell motility
AN947_16195	COG1749	Flagellar hook protein flgE
AN947_16200	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AN947_16205	COG1558	bacterial-type flagellum-dependent cell motility
AN947_16210	COG1815	bacterial-type flagellum-dependent cell motility
AN947_16215	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AN947_16220	COG0784	Response regulator, receiver
AN947_16220	COG0835	chemotaxis
AN947_16255	COG2226	methyltransferase
AN947_16255	COG3433	isochorismatase activity
AN947_16255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AN947_16260	COG2375	cellular response to nickel ion
AN947_16265	COG4774	siderophore transport
AN947_16265	COG1629	transport
AN947_16280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AN947_16285	COG2217	Heavy metal translocating P-type atpase
AN947_16285	COG2608	mercury ion transmembrane transporter activity
AN947_16300	COG3735	TraB family
AN947_16315	COG2840	Smr protein MutS2
AN947_16320	COG1187	pseudouridine synthase activity
AN947_16325	COG3706	GGDEF domain
AN947_16330	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AN947_16335	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AN947_16340	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AN947_16345	COG0121	glutamine amidotransferase
AN947_16350	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AN947_16355	COG1960	acyl-CoA dehydrogenase activity
AN947_16365	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AN947_16370	COG0328	RNA-DNA hybrid ribonuclease activity
AN947_16375	COG2226	methyltransferase
AN947_16380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AN947_16385	COG1388	LysM domain
AN947_16385	COG0741	lytic transglycosylase activity
AN947_16395	COG0347	Belongs to the P(II) protein family
AN947_16400	COG3479	Phenolic acid decarboxylase
AN947_16410	COG0037	tRNA processing
AN947_16415	COG0825	malonyl-CoA metabolic process
AN947_16420	COG0587	DNA-directed DNA polymerase activity
AN947_16425	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AN947_16430	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AN947_16435	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AN947_16440	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AN947_16445	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AN947_16450	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
AN947_16465	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AN947_16470	COG0575	Belongs to the CDS family
AN947_16475	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AN947_16480	COG0233	cytoplasmic translational termination
AN947_16485	COG0528	UMP kinase activity
AN947_16490	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AN947_16495	COG0052	Belongs to the universal ribosomal protein uS2 family
AN947_16500	COG0024	Methionine aminopeptidase
AN947_16505	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AN947_16515	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AN947_16520	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AN947_16525	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AN947_16530	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AN947_16545	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AN947_16545	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AN947_16550	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AN947_16555	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AN947_16560	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AN947_16575	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AN947_16580	COG2252	PERMEase
AN947_16585	COG2195	Cleaves the N-terminal amino acid of tripeptides
AN947_16590	COG0189	ligase activity
AN947_16590	COG4067	protein conserved in archaea
AN947_16595	COG0189	ligase activity
AN947_16605	COG0733	neurotransmitter:sodium symporter activity
AN947_16610	COG3706	GGDEF domain
AN947_16625	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AN947_16635	COG1477	protein flavinylation
AN947_16640	COG2871	sodium ion transport
AN947_16645	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AN947_16650	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AN947_16655	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AN947_16660	COG1805	sodium ion transport
AN947_16665	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AN947_16670	COG0271	Belongs to the BolA IbaG family
AN947_16675	COG2813	Specifically methylates the guanine in position
AN947_16685	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AN947_16690	COG2211	Major facilitator Superfamily
AN947_16700	COG1595	DNA-templated transcription, initiation
AN947_16710	COG3248	Nucleoside-binding outer membrane protein
AN947_16715	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AN947_16720	COG0693	protein deglycase activity
AN947_16725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AN947_16730	COG2166	iron-sulfur cluster assembly
AN947_16735	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AN947_16740	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AN947_16750	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AN947_16750	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AN947_16765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AN947_16770	COG1074	ATP-dependent DNA helicase activity
AN947_16775	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AN947_16790	COG3141	response to X-ray
AN947_16805	COG0456	acetyltransferase
AN947_16810	COG0569	domain protein
AN947_16810	COG0189	ligase activity
AN947_16825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AN947_16830	COG1609	Transcriptional regulator
AN947_16835	COG3250	beta-galactosidase activity
AN947_16850	COG1022	Amp-dependent synthetase and ligase
AN947_16855	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AN947_16860	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AN947_16870	COG0560	Phosphoserine phosphatase
AN947_16880	COG0813	purine-nucleoside phosphorylase activity
AN947_16885	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AN947_16890	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AN947_16895	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AN947_16905	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AN947_16910	COG0084	hydrolase, TatD family'
AN947_16920	COG1115	amino acid carrier protein
AN947_16935	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AN947_16940	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AN947_16945	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
AN947_16950	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AN947_16955	COG0083	homoserine kinase activity
AN947_16970	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AN947_16980	COG0745	RESPONSE REGULATOR receiver
AN947_16985	COG5002	protein histidine kinase activity
AN947_16985	COG2198	Histidine kinase
AN947_16985	COG0784	Response regulator, receiver
AN947_16990	COG5001	Diguanylate cyclase
AN947_16990	COG4251	negative regulation of phosphorylation
AN947_16990	COG2203	Gaf domain
AN947_16990	COG3706	GGDEF domain
AN947_16995	COG1242	4 iron, 4 sulfur cluster binding
AN947_17000	COG0069	glutamate synthase activity
AN947_17000	COG0070	glutamate synthase
AN947_17000	COG0067	glutamate synthase
AN947_17010	COG0070	glutamate synthase
AN947_17010	COG0069	glutamate synthase activity
AN947_17010	COG0067	glutamate synthase
AN947_17015	COG0493	'glutamate synthase
AN947_17025	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AN947_17035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AN947_17040	COG2860	membrane
AN947_17045	COG0583	DNA-binding transcription factor activity
AN947_17050	COG0730	response to heat
AN947_17060	COG4172	Belongs to the ABC transporter superfamily
AN947_17080	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AN947_17085	COG0505	Belongs to the CarA family
AN947_17095	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AN947_17100	COG0494	nUDIX hydrolase
AN947_17110	COG0653	protein targeting
AN947_17120	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AN947_17125	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AN947_17135	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AN947_17140	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AN947_17145	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AN947_17150	COG0772	Belongs to the SEDS family
AN947_17155	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AN947_17160	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AN947_17165	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AN947_17170	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AN947_17175	COG0768	penicillin binding
AN947_17180	COG3116	cell division
AN947_17185	COG0275	rRNA processing
AN947_17190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AN947_17195	COG0508	dehydrogenase complex catalyzes the overall conversion of
AN947_17200	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AN947_17205	COG2186	Transcriptional regulator
AN947_17210	COG0737	Belongs to the 5'-nucleotidase family
AN947_17215	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AN947_17220	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AN947_17225	COG4974	Belongs to the 'phage' integrase family
AN947_17230	COG0716	FMN binding
AN947_17250	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AN947_17255	COG1459	type II secretion system
AN947_17265	COG0237	dephospho-CoA kinase activity
AN947_17270	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AN947_17275	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AN947_17285	COG0187	DNA topoisomerase II activity
AN947_17290	COG3150	esterase
AN947_17300	COG3151	Protein conserved in bacteria
AN947_17305	COG0494	nUDIX hydrolase
AN947_17310	COG1538	Outer membrane efflux protein
AN947_17320	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AN947_17325	COG0840	transmembrane signaling receptor activity
AN947_17330	COG3025	triphosphatase activity
AN947_17335	COG1392	Phosphate transport regulator
AN947_17340	COG0306	phosphate transporter
AN947_17345	COG4991	sh3 domain protein
AN947_17355	COG3409	Peptidoglycan-binding domain 1 protein
AN947_17355	COG3267	Type II secretory pathway component ExeA
AN947_17365	COG0148	phosphopyruvate hydratase activity
AN947_17370	COG0504	CTP synthase activity
AN947_17375	COG3956	TIGRFAM MazG family protein
AN947_17380	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AN947_17385	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AN947_17395	COG5001	Diguanylate cyclase
AN947_17410	COG0736	holo-[acyl-carrier-protein] synthase activity
AN947_17415	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AN947_17420	COG1381	Involved in DNA repair and RecF pathway recombination
AN947_17425	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AN947_17430	COG0571	ribonuclease III activity
AN947_17435	COG0681	Belongs to the peptidase S26 family
AN947_17440	COG0481	GTPase activity
AN947_17445	COG3086	response to oxidative stress
AN947_17450	COG3026	antisigma factor binding
AN947_17460	COG1595	DNA-templated transcription, initiation
AN947_17470	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AN947_17480	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AN947_17485	COG0354	folic acid binding
AN947_17495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AN947_17500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AN947_17510	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AN947_17515	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AN947_17520	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AN947_17525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AN947_17530	COG0440	acetolactate synthase activity
AN947_17535	COG0028	Belongs to the TPP enzyme family
AN947_17540	COG1022	Amp-dependent synthetase and ligase
AN947_17545	COG0583	DNA-binding transcription factor activity
AN947_17565	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AN947_17570	COG0473	3-isopropylmalate dehydrogenase activity
AN947_17575	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AN947_17580	COG0066	3-isopropylmalate dehydratase activity
AN947_17625	COG3437	response regulator, receiver
AN947_17640	COG0795	lipopolysaccharide-transporting ATPase activity
AN947_17645	COG0795	lipopolysaccharide-transporting ATPase activity
AN947_17650	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AN947_17655	COG2927	DNA polymerase III (CHI subunit)
AN947_17660	COG0525	valine-tRNA ligase activity
AN947_17665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AN947_17670	COG0564	pseudouridine synthase activity
AN947_17685	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AN947_17690	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AN947_17700	COG0540	Belongs to the ATCase OTCase family
AN947_17705	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AN947_17710	COG0251	oxidation-reduction process
AN947_17715	COG0204	Acyl-transferase
AN947_17720	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AN947_17725	COG5007	Belongs to the BolA IbaG family
AN947_17735	COG2854	intermembrane phospholipid transfer
AN947_17740	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AN947_17745	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AN947_17750	COG1127	ABC transporter
AN947_17765	COG0517	IMP dehydrogenase activity
AN947_17765	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AN947_17780	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AN947_17785	COG1137	ATPase activity
AN947_17795	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AN947_17800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AN947_17805	COG1660	Displays ATPase and GTPase activities
AN947_17810	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AN947_17815	COG2239	Acts as a magnesium transporter
AN947_17820	COG0312	modulator of DNA gyrase
AN947_17825	COG3028	Belongs to the UPF0307 family
AN947_17830	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AN947_17835	COG1178	ABC-type Fe3 transport system permease component
AN947_17840	COG4143	(ABC) transporter
AN947_17845	COG0163	prenyltransferase activity
AN947_17850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AN947_17860	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AN947_17865	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AN947_17870	COG2105	PFAM AIG2 family protein
AN947_17880	COG0729	surface antigen
AN947_17885	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AN947_17890	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AN947_17905	COG1136	(ABC) transporter
AN947_17925	COG0529	Catalyzes the synthesis of activated sulfate
AN947_17930	COG2895	sulfate adenylyltransferase (ATP) activity
AN947_17935	COG0175	sulfate reduction
AN947_17940	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AN947_17940	COG1648	precorrin-2 dehydrogenase activity
AN947_17945	COG0737	Belongs to the 5'-nucleotidase family
AN947_17955	COG0513	Belongs to the DEAD box helicase family
AN947_17960	COG2153	protein acetylation
AN947_17965	COG0697	spore germination
AN947_17970	COG3266	domain, Protein
AN947_17970	COG3061	Opacity-associated protein A
AN947_17975	COG0545	Peptidyl-prolyl cis-trans isomerase
AN947_17990	COG0202	RNA polymerase activity
AN947_17995	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AN947_18005	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AN947_18015	COG0201	protein transport
AN947_18020	COG0200	Binds to the 23S rRNA
AN947_18025	COG1841	ribosomal large subunit assembly
AN947_18030	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AN947_18035	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AN947_18040	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AN947_18045	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AN947_18050	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AN947_18055	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AN947_18060	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AN947_18065	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AN947_18070	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AN947_18075	COG0255	Belongs to the universal ribosomal protein uL29 family
AN947_18080	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AN947_18085	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AN947_18090	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AN947_18095	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AN947_18100	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AN947_18105	COG0089	rRNA binding
AN947_18110	COG0088	Forms part of the polypeptide exit tunnel
AN947_18115	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AN947_18120	COG0051	transcription antitermination factor activity, RNA binding
AN947_18125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AN947_18130	COG0557	exoribonuclease II activity
AN947_18135	COG3083	sulfuric ester hydrolase activity
AN947_18140	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AN947_18145	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AN947_18155	COG1047	Peptidyl-prolyl cis-trans
AN947_18170	COG2249	NAD(P)H dehydrogenase (quinone) activity
AN947_18175	COG0488	(ABC) transporter
AN947_18185	COG0429	hydrolase of the alpha beta-hydrolase fold
AN947_18195	COG3954	Phosphoribulokinase
AN947_18200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AN947_18210	COG1012	belongs to the aldehyde dehydrogenase family
AN947_18220	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AN947_18230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AN947_18245	COG0180	Tryptophanyl-tRNA synthetase
AN947_18250	COG0546	phosphoglycolate phosphatase activity
AN947_18255	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AN947_18260	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AN947_18275	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AN947_18305	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AN947_18315	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AN947_18315	COG0678	peroxiredoxin activity
AN947_18320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AN947_18330	COG0165	Argininosuccinate lyase
AN947_18335	COG0137	argininosuccinate synthase activity
AN947_18340	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AN947_18345	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AN947_18350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AN947_18355	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AN947_18365	COG1045	serine acetyltransferase
AN947_18370	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AN947_18375	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AN947_18380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AN947_18385	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AN947_18390	COG1053	succinate dehydrogenase
AN947_18395	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AN947_18400	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AN947_18405	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AN947_18410	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AN947_18425	COG0459	protein refolding
AN947_18430	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AN947_18465	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AN947_18470	COG1575	Belongs to the MenA family. Type 1 subfamily
AN947_18475	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AN947_18480	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AN947_18485	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AN947_18490	COG1609	Transcriptional regulator
AN947_18495	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AN947_18500	COG0254	rRNA binding
AN947_18505	COG0281	malic enzyme
AN947_18510	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
AN947_18515	COG0626	cystathionine gamma-synthase activity
AN947_18520	COG0460	homoserine dehydrogenase
AN947_18520	COG0527	aspartate kinase activity
AN947_18525	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AN947_18530	COG3074	FtsZ-dependent cytokinesis
AN947_18535	COG1494	fructose-1,6-bisphosphatase
AN947_18540	COG0205	6-phosphofructokinase activity
AN947_18545	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AN947_18555	COG0745	RESPONSE REGULATOR receiver
AN947_18560	COG2205	protein histidine kinase activity
AN947_18570	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AN947_18575	COG3030	protein affecting phage T7 exclusion by the F plasmid
AN947_18580	COG3706	GGDEF domain
AN947_18585	COG1027	Aspartate ammonia-lyase
AN947_18590	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AN947_18605	COG4232	protein-disulfide reductase activity
AN947_18615	COG3263	regulation of cellular component size
AN947_18625	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AN947_18630	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AN947_18635	COG0194	GDP metabolic process
AN947_18640	COG1758	RNA polymerase activity
AN947_18645	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AN947_18650	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AN947_18655	COG2233	PERMEase
AN947_18665	COG0745	RESPONSE REGULATOR receiver
AN947_18670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AN947_18675	COG2183	response to ionizing radiation
AN947_18685	COG0596	Alpha beta hydrolase
AN947_18690	COG1040	competence protein
AN947_18695	COG0316	Belongs to the HesB IscA family
AN947_18695	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AN947_18700	COG0494	nUDIX hydrolase
AN947_18705	COG1218	3'(2'),5'-bisphosphate nucleotidase
AN947_18720	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AN947_18725	COG3156	type II secretion system protein K
AN947_18730	COG4795	General secretion pathway protein
AN947_18735	COG2165	general secretion pathway protein
AN947_18740	COG2165	general secretion pathway protein
AN947_18745	COG2165	general secretion pathway protein
AN947_18750	COG1459	type II secretion system
AN947_18755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AN947_18765	COG3031	protein transport across the cell outer membrane
AN947_18770	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AN947_18775	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AN947_18780	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AN947_18790	COG0456	acetyltransferase
AN947_18795	COG1490	D-aminoacyl-tRNA deacylase activity
AN947_18820	COG0174	glutamine synthetase
AN947_18830	COG3852	Histidine kinase
AN947_18840	COG3300	MHYT domain
AN947_18840	COG5001	Diguanylate cyclase
AN947_18845	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AN947_18925	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
AN947_18930	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AN947_18935	COG1739	Uncharacterized protein family UPF0029
AN947_18940	COG1024	Enoyl-CoA hydratase
AN947_18940	COG1250	3-hydroxyacyl-CoA dehydrogenase
AN947_18950	COG0583	DNA-binding transcription factor activity
AN947_18955	COG2814	Major facilitator Superfamily
AN947_18960	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AN947_18965	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AN947_18970	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AN947_18975	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AN947_18980	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AN947_18985	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AN947_18990	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AN947_19000	COG0356	it plays a direct role in the translocation of protons across the membrane
AN947_19005	COG3312	ion transport
AN947_19010	COG1475	DNA binding
AN947_19015	COG1192	Involved in chromosome partitioning
AN947_19020	COG0357	Ribosomal RNA small subunit methyltransferase G
AN947_19025	COG0445	tRNA wobble uridine modification
AN947_19035	COG3316	Transposase and inactivated derivatives
AN947_19065	COG1660	Displays ATPase and GTPase activities
AN947_19085	COG3316	Transposase and inactivated derivatives
AN947_19100	COG3316	Transposase and inactivated derivatives
AN947_19135	COG3316	Transposase and inactivated derivatives
AN947_19145	COG3173	Aminoglycoside phosphotransferase
AN947_19160	COG3316	Transposase and inactivated derivatives
AN947_19200	COG3316	Transposase and inactivated derivatives
AN947_19275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AN947_19290	COG1192	Involved in chromosome partitioning
AN947_19375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AN947_19465	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AN947_19490	COG5001	Diguanylate cyclase
AN947_19525	COG0714	Associated with various cellular activities
AN947_19535	COG0629	single-stranded DNA binding
AN947_19580	COG0633	Ferredoxin
AN947_19750	COG4974	Belongs to the 'phage' integrase family
AN947_19920	COG0616	signal peptide processing
AN947_19970	COG0776	regulation of translation
AN947_20035	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AN947_20095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol