locus-tag	class	description
O3Y_00005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
O3Y_00010	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
O3Y_00015	COG0706	membrane insertase activity
O3Y_00020	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
O3Y_00025	COG0594	ribonuclease P activity
O3Y_00030	COG0230	Belongs to the bacterial ribosomal protein bL34 family
O3Y_00035	COG1126	abc transporter atp-binding protein
O3Y_00050	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
O3Y_00055	COG0592	DNA-directed DNA polymerase activity
O3Y_00060	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
O3Y_00065	COG0187	DNA topoisomerase II activity
O3Y_00080	COG0071	Belongs to the small heat shock protein (HSP20) family
O3Y_00085	COG3977	Valine--pyruvate aminotransferase
O3Y_00090	COG0751	glycine-tRNA ligase activity
O3Y_00095	COG0752	glycyl-tRNA synthetase alpha subunit
O3Y_00100	COG2119	membrane
O3Y_00110	COG0425	Belongs to the sulfur carrier protein TusA family
O3Y_00120	COG0604	alcohol dehydrogenase
O3Y_00130	COG0129	dihydroxy-acid dehydratase activity
O3Y_00135	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O3Y_00150	COG0606	chelatase, subunit chli
O3Y_00155	COG0204	Acyl-transferase
O3Y_00160	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
O3Y_00165	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
O3Y_00175	COG3084	Protein conserved in bacteria
O3Y_00180	COG4326	sporulation control protein
O3Y_00185	COG1272	protein, Hemolysin III
O3Y_00195	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
O3Y_00200	COG0569	domain protein
O3Y_00205	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
O3Y_00205	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
O3Y_00210	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
O3Y_00215	COG0242	peptide deformylase activity
O3Y_00220	COG1652	LysM domain
O3Y_00225	COG0758	DNA mediated transformation
O3Y_00230	COG2922	Belongs to the Smg family
O3Y_00235	COG0551	DNA topoisomerase type I activity
O3Y_00240	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
O3Y_00245	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
O3Y_00250	COG0009	L-threonylcarbamoyladenylate synthase
O3Y_00255	COG0408	coproporphyrinogen oxidase activity
O3Y_00260	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
O3Y_00270	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
O3Y_00280	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
O3Y_00285	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
O3Y_00295	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
O3Y_00300	COG2104	thiamine diphosphate biosynthetic process
O3Y_00305	COG2022	thiamine diphosphate biosynthetic process
O3Y_00310	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
O3Y_00315	COG0006	proline dipeptidase activity
O3Y_00315	COG0006	proline dipeptidase activity
O3Y_00335	COG1522	sequence-specific DNA binding
O3Y_00340	COG5001	Diguanylate cyclase
O3Y_00340	COG5002	protein histidine kinase activity
O3Y_00345	COG0742	ribosomal rna small subunit methyltransferase
O3Y_00355	COG0697	spore germination
O3Y_00360	COG0589	response to stress
O3Y_00365	COG1528	Iron-storage protein
O3Y_00375	COG2081	HI0933 family
O3Y_00385	COG1322	Protein conserved in bacteria
O3Y_00390	COG2226	methyltransferase
O3Y_00400	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
O3Y_00405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O3Y_00410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O3Y_00415	COG0805	protein transport
O3Y_00420	COG1858	cytochrome C peroxidase
O3Y_00425	COG0534	Mate efflux family protein
O3Y_00435	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
O3Y_00440	COG2937	Belongs to the GPAT DAPAT family
O3Y_00445	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
O3Y_00450	COG3161	chorismate lyase activity
O3Y_00455	COG1580	Controls the rotational direction of flagella during chemotaxis
O3Y_00460	COG0840	transmembrane signaling receptor activity
O3Y_00470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O3Y_00475	COG0084	hydrolase, TatD family'
O3Y_00490	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O3Y_00490	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O3Y_00495	COG0218	Necessary for normal cell division and for the maintenance of normal septation
O3Y_00510	COG3078	GTPase activator activity
O3Y_00520	COG0635	Involved in the biosynthesis of porphyrin-containing compound
O3Y_00525	COG3071	HemY protein
O3Y_00530	COG2959	enzyme of heme biosynthesis
O3Y_00535	COG1587	Uroporphyrinogen-III synthase
O3Y_00540	COG0181	hydroxymethylbilane synthase activity
O3Y_00545	COG3072	Adenylate cyclase
O3Y_00550	COG1965	Belongs to the frataxin family
O3Y_00560	COG0019	diaminopimelate decarboxylase activity
O3Y_00565	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
O3Y_00575	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
O3Y_00580	COG1011	Hydrolase
O3Y_00585	COG3287	FIST C domain
O3Y_00585	COG2200	EAL domain
O3Y_00585	COG2199	diguanylate cyclase activity
O3Y_00600	COG0561	phosphatase activity
O3Y_00605	COG2267	carboxylic ester hydrolase activity
O3Y_00610	COG1280	lysine exporter protein (LysE YggA)
O3Y_00615	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
O3Y_00620	COG0783	Belongs to the Dps family
O3Y_00655	COG0742	ribosomal rna small subunit methyltransferase
O3Y_00660	COG0552	protein localization to endoplasmic reticulum
O3Y_00665	COG2884	Cell division ATP-binding protein ftsE
O3Y_00670	COG2177	Part of the ABC transporter FtsEX involved in
O3Y_00675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
O3Y_00680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O3Y_00695	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O3Y_00700	COG4206	TonB-dependent receptor
O3Y_00705	COG1404	Belongs to the peptidase S8 family
O3Y_00710	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
O3Y_00720	COG0583	DNA-binding transcription factor activity
O3Y_00725	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
O3Y_00730	COG2960	long-chain fatty acid transporting porin activity
O3Y_00735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O3Y_00740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O3Y_00745	COG1309	transcriptional regulator
O3Y_00770	COG0747	negative chemotaxis
O3Y_00780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O3Y_00790	COG2131	deaminase
O3Y_00855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O3Y_00860	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
O3Y_00870	COG0210	DNA helicase
O3Y_00875	COG1280	lysine exporter protein (LysE YggA)
O3Y_00890	COG2962	Rard protein
O3Y_00895	COG0514	ATP-dependent DNA helicase (RecQ)
O3Y_00910	COG1132	(ABC) transporter
O3Y_00915	COG4774	siderophore transport
O3Y_00920	COG1120	ATPase activity
O3Y_00940	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
O3Y_00945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O3Y_00945	COG1263	PTS System
O3Y_00955	COG1561	YicC-like family, N-terminal region
O3Y_00960	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
O3Y_00965	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
O3Y_00970	COG1560	Kdo2-lipid A biosynthetic process
O3Y_00975	COG1560	Kdo2-lipid A biosynthetic process
O3Y_00980	COG1309	transcriptional regulator
O3Y_00985	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
O3Y_01000	COG0227	Belongs to the bacterial ribosomal protein bL28 family
O3Y_01005	COG0267	Belongs to the bacterial ribosomal protein bL33 family
O3Y_01015	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
O3Y_01020	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
O3Y_01025	COG0859	PFAM glycosyl transferase family 9
O3Y_01030	COG0463	Glycosyl transferase, family 2
O3Y_01035	COG0859	PFAM glycosyl transferase family 9
O3Y_01040	COG3642	lipopolysaccharide core region biosynthetic process
O3Y_01070	COG1519	Transferase
O3Y_01105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O3Y_01110	COG0662	Cupin 2, conserved barrel domain protein
O3Y_01110	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
O3Y_01115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O3Y_01120	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
O3Y_01150	COG0318	PFAM AMP-dependent synthetase and ligase
O3Y_01155	COG1454	alcohol dehydrogenase
O3Y_01155	COG1012	belongs to the aldehyde dehydrogenase family
O3Y_01225	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
O3Y_01230	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
O3Y_01235	COG0668	transmembrane transport
O3Y_01240	COG1573	uracil-dna glycosylase
O3Y_01250	COG3068	Protein conserved in bacteria
O3Y_01260	COG1940	carbohydrate kinase activity
O3Y_01265	COG1253	flavin adenine dinucleotide binding
O3Y_01270	COG0776	regulation of translation
O3Y_01280	COG0151	Belongs to the GarS family
O3Y_01285	COG0138	bifunctional purine biosynthesis protein purh
O3Y_01290	COG0789	Transcriptional regulator
O3Y_01295	COG3710	Transcriptional regulator
O3Y_01300	COG0531	amino acid
O3Y_01305	COG1982	Orn Lys Arg decarboxylase major
O3Y_01310	COG0840	transmembrane signaling receptor activity
O3Y_01330	COG0800	Aldolase
O3Y_01340	COG3265	gluconokinase activity
O3Y_01345	COG0129	dihydroxy-acid dehydratase activity
O3Y_01350	COG1609	Transcriptional regulator
O3Y_01355	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
O3Y_01360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O3Y_01365	COG2264	protein methyltransferase activity
O3Y_01370	COG0439	Biotin carboxylase
O3Y_01375	COG0511	ligase activity, forming carbon-carbon bonds
O3Y_01380	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
O3Y_01385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O3Y_01400	COG2814	Major facilitator Superfamily
O3Y_01405	COG0784	Response regulator, receiver
O3Y_01405	COG2205	protein histidine kinase activity
O3Y_01410	COG0248	Ppx GppA phosphatase
O3Y_01415	COG0513	Belongs to the DEAD box helicase family
O3Y_01420	COG3118	belongs to the thioredoxin family
O3Y_01425	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
O3Y_01435	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
O3Y_01450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O3Y_01460	COG0812	UDP-N-acetylmuramate dehydrogenase activity
O3Y_01470	COG1072	(Pantothenic acid kinase))
O3Y_01475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
O3Y_01480	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
O3Y_01485	COG0250	Participates in transcription elongation, termination and antitermination
O3Y_01490	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
O3Y_01495	COG0081	regulation of translation
O3Y_01500	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
O3Y_01505	COG0222	ribosome binding
O3Y_01510	COG0085	RNA polymerase activity
O3Y_01515	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
O3Y_01520	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
O3Y_01525	COG2816	NAD+ diphosphatase activity
O3Y_01530	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
O3Y_01545	COG4942	peptidase
O3Y_01550	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
O3Y_01560	COG0471	metal ion transport
O3Y_01565	COG0688	phosphatidylethanolamine metabolic process
O3Y_01570	COG1162	GTPase activity
O3Y_01575	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
O3Y_01580	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
O3Y_01585	COG0802	atpase or kinase
O3Y_01595	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
O3Y_01600	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
O3Y_01605	COG1923	regulation of RNA biosynthetic process
O3Y_01610	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
O3Y_01615	COG0330	HflC and HflK could
O3Y_01620	COG0330	HflC and HflK could
O3Y_01625	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
O3Y_01630	COG2900	Belongs to the SlyX family
O3Y_01640	COG0545	Peptidyl-prolyl cis-trans isomerase
O3Y_01645	COG2964	Protein conserved in bacteria
O3Y_01650	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
O3Y_01655	COG2923	Belongs to the DsrF TusC family
O3Y_01665	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
O3Y_01670	COG0049	tRNA binding
O3Y_01675	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
O3Y_01680	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
O3Y_01685	COG2906	2 iron, 2 sulfur cluster binding
O3Y_01695	COG0360	Binds together with S18 to 16S ribosomal RNA
O3Y_01700	COG2965	DNA replication, synthesis of RNA primer
O3Y_01705	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
O3Y_01710	COG0359	binds to the 23S rRNA
O3Y_01720	COG0305	Participates in initiation and elongation during chromosome replication
O3Y_01725	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
O3Y_01730	COG0432	Pfam Uncharacterised protein family UPF0047
O3Y_01735	COG0166	Belongs to the GPI family
O3Y_01750	COG0735	belongs to the Fur family
O3Y_01755	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O3Y_01775	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
O3Y_01780	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O3Y_01785	COG0175	sulfate reduction
O3Y_01795	COG1410	methionine synthase
O3Y_01795	COG0646	methionine synthase
O3Y_01800	COG0527	aspartate kinase activity
O3Y_01805	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
O3Y_01815	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
O3Y_01830	COG0629	single-stranded DNA binding
O3Y_01835	COG2199	diguanylate cyclase activity
O3Y_01835	COG2200	EAL domain
O3Y_01860	COG3267	Type II secretory pathway component ExeA
O3Y_01860	COG3409	Peptidoglycan-binding domain 1 protein
O3Y_01870	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O3Y_01875	COG1459	type II secretion system
O3Y_01920	COG1077	Cell shape determining protein MreB Mrl
O3Y_01925	COG1792	Involved in formation and maintenance of cell shape
O3Y_01930	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
O3Y_01935	COG0424	maF-like protein
O3Y_01940	COG1530	ribonuclease E activity
O3Y_01945	COG3164	Protein of unknown function
O3Y_01950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O3Y_01955	COG0312	modulator of DNA gyrase
O3Y_01960	COG2235	arginine
O3Y_01980	COG0589	response to stress
O3Y_01995	COG1438	arginine binding
O3Y_02000	COG0039	L-malate dehydrogenase activity
O3Y_02005	COG0531	amino acid
O3Y_02010	COG0142	geranyltranstransferase activity
O3Y_02015	COG0261	This protein binds to 23S rRNA in the presence of protein L20
O3Y_02020	COG0211	Belongs to the bacterial ribosomal protein bL27 family
O3Y_02025	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
O3Y_02030	COG2966	Psort location CytoplasmicMembrane, score
O3Y_02035	COG3610	response to peptide
O3Y_02045	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
O3Y_02050	COG2967	ApaG domain
O3Y_02055	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
O3Y_02060	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
O3Y_02065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O3Y_02070	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
O3Y_02075	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
O3Y_02085	COG0741	lytic transglycosylase activity
O3Y_02090	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
O3Y_02095	COG1194	a g-specific adenine glycosylase
O3Y_02100	COG0220	tRNA (guanine-N7-)-methyltransferase activity
O3Y_02105	COG2066	Belongs to the glutaminase family
O3Y_02110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
O3Y_02115	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
O3Y_02125	COG1872	DUF167
O3Y_02130	COG0762	integral membrane protein
O3Y_02135	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
O3Y_02140	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
O3Y_02160	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
O3Y_02165	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
O3Y_02170	COG1678	Uncharacterized ACR, COG1678
O3Y_02175	COG0189	ligase activity
O3Y_02180	COG1385	rRNA (uridine-N3-)-methyltransferase activity
O3Y_02185	COG2356	endonuclease I
O3Y_02190	COG3091	SprT-like family
O3Y_02195	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
O3Y_02205	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
O3Y_02210	COG0583	DNA-binding transcription factor activity
O3Y_02215	COG4771	TonB-dependent receptor
O3Y_02220	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O3Y_02225	COG0126	phosphoglycerate kinase activity
O3Y_02230	COG0191	fructose-bisphosphate aldolase activity
O3Y_02240	COG0668	transmembrane transport
O3Y_02245	COG1279	arginine transmembrane transporter activity
O3Y_02250	COG0583	DNA-binding transcription factor activity
O3Y_02260	COG0469	pyruvate kinase activity
O3Y_02265	COG1349	DNA-binding transcription factor activity
O3Y_02270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
O3Y_02275	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
O3Y_02330	COG0328	RNA-DNA hybrid ribonuclease activity
O3Y_02370	COG0739	heme binding
O3Y_02400	COG2003	Belongs to the UPF0758 family
O3Y_02430	COG0582	viral genome integration into host DNA
O3Y_02435	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
O3Y_02440	COG0358	DNA primase activity
O3Y_02445	COG1610	YqeY-like protein
O3Y_02450	COG0828	Belongs to the bacterial ribosomal protein bS21 family
O3Y_02455	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
O3Y_02465	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
O3Y_02475	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
O3Y_02480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
O3Y_02485	COG1968	undecaprenyl-diphosphatase activity
O3Y_02490	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
O3Y_02495	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
O3Y_02500	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
O3Y_02505	COG0585	pseudouridine synthase activity
O3Y_02510	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
O3Y_02515	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
O3Y_02520	COG4942	peptidase
O3Y_02520	COG1388	LysM domain
O3Y_02525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
O3Y_02530	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
O3Y_02550	COG4208	sulfate ABC transporter
O3Y_02555	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
O3Y_02565	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
O3Y_02570	COG2137	regulation of response to DNA damage stimulus
O3Y_02575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
O3Y_02580	COG0527	aspartate kinase activity
O3Y_02585	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
O3Y_02590	COG3630	sodium ion export across plasma membrane
O3Y_02595	COG5016	pyruvate
O3Y_02595	COG0511	ligase activity, forming carbon-carbon bonds
O3Y_02600	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
O3Y_02610	COG1238	metal cluster binding
O3Y_02615	COG0612	Peptidase, M16
O3Y_02620	COG2918	glutathione biosynthetic process
O3Y_02625	COG1854	S-ribosylhomocysteine lyase activity
O3Y_02630	COG4536	flavin adenine dinucleotide binding
O3Y_02635	COG4137	Cytochrome C assembly protein
O3Y_02640	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
O3Y_02645	COG0228	four-way junction DNA binding
O3Y_02650	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
O3Y_02655	COG0336	Belongs to the RNA methyltransferase TrmD family
O3Y_02660	COG0335	large ribosomal subunit rRNA binding
O3Y_02665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O3Y_02670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O3Y_02680	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
O3Y_02685	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
O3Y_02690	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
O3Y_02695	COG0723	plastoquinol--plastocyanin reductase activity
O3Y_02700	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
O3Y_02705	COG2857	Cytochrome c1
O3Y_02710	COG0625	glutathione transferase activity
O3Y_02715	COG2969	positive regulation of protein catabolic process
O3Y_02720	COG2823	Periplasmic or secreted lipoprotein
O3Y_02725	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
O3Y_02730	COG0792	nuclease activity
O3Y_02735	COG3107	peptidoglycan biosynthetic process
O3Y_02740	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
O3Y_02745	COG1131	(ABC) transporter
O3Y_02750	COG0842	Transport permease protein
O3Y_02755	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
O3Y_02760	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
O3Y_02765	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
O3Y_02775	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O3Y_02780	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
O3Y_02785	COG1489	DNA binding
O3Y_02795	COG1643	Atp-dependent helicase
O3Y_02800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O3Y_02805	COG1752	Esterase of the alpha-beta hydrolase superfamily
O3Y_02810	COG1049	propionate catabolic process, 2-methylcitrate cycle
O3Y_02815	COG3112	Uncharacterised protein family (UPF0231)
O3Y_02820	COG0347	Belongs to the P(II) protein family
O3Y_02825	COG0004	ammonium transporteR
O3Y_02830	COG1840	ABC-type Fe3 transport system, periplasmic component
O3Y_02840	COG3842	ATPase activity
O3Y_02860	COG2971	BadF BadG BcrA BcrD
O3Y_02870	COG4608	Belongs to the ABC transporter superfamily
O3Y_02875	COG0444	Belongs to the ABC transporter superfamily
O3Y_02880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O3Y_02885	COG0601	transmembrane transport
O3Y_02890	COG0747	negative chemotaxis
O3Y_02900	COG2813	Specifically methylates the guanine in position
O3Y_02905	COG0628	permease
O3Y_02910	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
O3Y_02920	COG0316	Belongs to the HesB IscA family
O3Y_02935	COG0739	heme binding
O3Y_02940	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
O3Y_02945	COG2027	D-alanyl-D-alanine carboxypeptidase
O3Y_02950	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
O3Y_02955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O3Y_02960	COG1534	Rna-binding protein
O3Y_02965	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
O3Y_02970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
O3Y_02975	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
O3Y_02980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O3Y_02985	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
O3Y_02990	COG0779	Required for maturation of 30S ribosomal subunits
O3Y_02995	COG0195	Participates in both transcription termination and antitermination
O3Y_03000	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
O3Y_03005	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
O3Y_03010	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
O3Y_03015	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
O3Y_03020	COG1185	polyribonucleotide nucleotidyltransferase activity
O3Y_03025	COG4785	May be involved in cell division
O3Y_03060	COG3153	acetyltransferase
O3Y_03080	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
O3Y_03085	COG0513	Belongs to the DEAD box helicase family
O3Y_03090	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
O3Y_03100	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
O3Y_03105	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
O3Y_03110	COG2204	response regulator
O3Y_03120	COG0667	Aldo Keto reductase
O3Y_03125	COG3066	DNA modification
O3Y_03135	COG0494	nUDIX hydrolase
O3Y_03140	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
O3Y_03145	COG0730	response to heat
O3Y_03150	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
O3Y_03155	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
O3Y_03160	COG1283	sodium-dependent phosphate transmembrane transporter activity
O3Y_03165	COG0583	DNA-binding transcription factor activity
O3Y_03170	COG0640	Transcriptional regulator
O3Y_03175	COG0268	Binds directly to 16S ribosomal RNA
O3Y_03180	COG0728	peptidoglycan biosynthetic process
O3Y_03185	COG0196	riboflavin kinase activity
O3Y_03190	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
O3Y_03195	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
O3Y_03200	COG1047	Peptidyl-prolyl cis-trans
O3Y_03205	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
O3Y_03210	COG1966	Carbon starvation protein
O3Y_03225	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
O3Y_03230	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
O3Y_03235	COG1472	Belongs to the glycosyl hydrolase 3 family
O3Y_03240	COG3279	Response regulator of the LytR AlgR family
O3Y_03245	COG3275	phosphorelay sensor kinase activity
O3Y_03250	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
O3Y_03255	COG1605	Chorismate mutase
O3Y_03255	COG0287	Prephenate dehydrogenase
O3Y_03265	COG0488	(ABC) transporter
O3Y_03275	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
O3Y_03280	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
O3Y_03285	COG5001	Diguanylate cyclase
O3Y_03290	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
O3Y_03295	COG0077	Prephenate dehydratase
O3Y_03295	COG1605	Chorismate mutase
O3Y_03300	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
O3Y_03305	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O3Y_03310	COG0564	pseudouridine synthase activity
O3Y_03320	COG0542	response to heat
O3Y_03335	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
O3Y_03345	COG2974	May be involved in recombination
O3Y_03350	COG0745	RESPONSE REGULATOR receiver
O3Y_03355	COG5002	protein histidine kinase activity
O3Y_03365	COG0248	Ppx GppA phosphatase
O3Y_03385	COG0581	inorganic phosphate transmembrane transporter activity
O3Y_03390	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
O3Y_03405	COG3142	Participates in the control of copper homeostasis
O3Y_03410	COG0450	alkyl hydroperoxide reductase
O3Y_03415	COG0583	DNA-binding transcription factor activity
O3Y_03420	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
O3Y_03430	COG0517	IMP dehydrogenase activity
O3Y_03435	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
O3Y_03440	COG0343	queuine tRNA-ribosyltransferase activity
O3Y_03445	COG1862	Preprotein translocase
O3Y_03450	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O3Y_03455	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O3Y_03460	COG0483	inositol monophosphate 1-phosphatase activity
O3Y_03470	COG1959	2 iron, 2 sulfur cluster binding
O3Y_03475	COG1104	cysteine desulfurase activity
O3Y_03480	COG0822	iron-sulfur transferase activity
O3Y_03490	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
O3Y_03495	COG0443	Heat shock 70 kDa protein
O3Y_03500	COG0633	Ferredoxin
O3Y_03505	COG2975	iron-sulfur cluster assembly
O3Y_03510	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
O3Y_03515	COG0105	UTP biosynthetic process
O3Y_03520	COG0820	rRNA (adenine-C2-)-methyltransferase activity
O3Y_03530	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
O3Y_03535	COG0124	histidyl-tRNA synthetase
O3Y_03540	COG2976	Protein conserved in bacteria
O3Y_03545	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O3Y_03550	COG1160	GTP binding
O3Y_03565	COG1570	exodeoxyribonuclease VII activity
O3Y_03570	COG0517	IMP dehydrogenase activity
O3Y_03570	COG0516	GMP reductase activity
O3Y_03575	COG0519	Catalyzes the synthesis of GMP from XMP
O3Y_03575	COG0518	GMP synthase (glutamine-hydrolyzing) activity
O3Y_03585	COG1584	GPR1 FUN34 yaaH family protein
O3Y_03590	COG1535	isochorismatase
O3Y_03590	COG3433	isochorismatase activity
O3Y_03595	COG1021	2,3-dihydroxybenzoate-AMP ligase
O3Y_03600	COG1169	isochorismate synthase
O3Y_03605	COG1028	Short-chain dehydrogenase reductase Sdr
O3Y_03615	COG4592	Periplasmic binding protein
O3Y_03620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O3Y_03625	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O3Y_03630	COG1120	ATPase activity
O3Y_03640	COG0583	DNA-binding transcription factor activity
O3Y_03645	COG2015	COG2015, Alkyl sulfatase and related hydrolases
O3Y_03650	COG1115	amino acid carrier protein
O3Y_03655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O3Y_03660	COG0583	DNA-binding transcription factor activity
O3Y_03675	COG4565	transcriptional regulatory protein
O3Y_03685	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
O3Y_03690	COG0511	ligase activity, forming carbon-carbon bonds
O3Y_03690	COG5016	pyruvate
O3Y_03695	COG3630	sodium ion export across plasma membrane
O3Y_03705	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
O3Y_03710	COG3052	prosthetic group binding
O3Y_03715	COG2301	Belongs to the HpcH HpaI aldolase family
O3Y_03720	COG3051	citrate lyase alpha subunit
O3Y_03725	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
O3Y_03730	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
O3Y_03740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O3Y_03745	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
O3Y_03750	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
O3Y_03810	COG1012	belongs to the aldehyde dehydrogenase family
O3Y_03830	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
O3Y_03835	COG0840	transmembrane signaling receptor activity
O3Y_03840	COG3710	Transcriptional regulator
O3Y_03850	COG2165	general secretion pathway protein
O3Y_03865	COG4796	Type ii and iii secretion system protein
O3Y_03885	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O3Y_03890	COG1459	type II secretion system
O3Y_03900	COG2207	Transcriptional regulator
O3Y_03905	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
O3Y_03925	COG0739	heme binding
O3Y_03935	COG3064	Membrane
O3Y_03945	COG0582	viral genome integration into host DNA
O3Y_03950	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
O3Y_03955	COG2867	negative regulation of translational initiation
O3Y_03960	COG2914	Belongs to the UPF0125 (RnfH) family
O3Y_03965	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O3Y_03970	COG0497	DNA recombination
O3Y_03975	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
O3Y_03980	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
O3Y_03985	COG0443	Heat shock 70 kDa protein
O3Y_03990	COG0484	heat shock protein binding
O3Y_04020	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
O3Y_04025	COG0590	tRNA wobble adenosine to inosine editing
O3Y_04035	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
O3Y_04045	COG0047	phosphoribosylformylglycinamidine synthase activity
O3Y_04045	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
O3Y_04050	COG1943	Transposase
O3Y_04070	COG0442	prolyl-tRNA aminoacylation
O3Y_04075	COG1720	tRNA m6t6A37 methyltransferase activity
O3Y_04080	COG0254	rRNA binding
O3Y_04085	COG0257	Belongs to the bacterial ribosomal protein bL36 family
O3Y_04090	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
O3Y_04095	COG1671	Belongs to the UPF0178 family
O3Y_04105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O3Y_04120	COG3098	single-species biofilm formation
O3Y_04125	COG0564	pseudouridine synthase activity
O3Y_04130	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
O3Y_04135	COG0142	geranyltranstransferase activity
O3Y_04140	COG1722	exodeoxyribonuclease VII activity
O3Y_04145	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
O3Y_04155	COG0301	tRNA thio-modification
O3Y_04155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O3Y_04160	COG0583	DNA-binding transcription factor activity
O3Y_04165	COG2363	Small membrane protein
O3Y_04170	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O3Y_04175	COG1611	Belongs to the LOG family
O3Y_04180	COG3706	GGDEF domain
O3Y_04190	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
O3Y_04190	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
O3Y_04200	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
O3Y_04205	COG1464	Belongs to the NlpA lipoprotein family
O3Y_04210	COG2011	ABC-type metal ion transport system permease component
O3Y_04215	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
O3Y_04220	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
O3Y_04225	COG1609	Transcriptional regulator
O3Y_04230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O3Y_04230	COG1263	PTS System
O3Y_04235	COG0366	Alpha amylase catalytic
O3Y_04250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O3Y_04255	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O3Y_04260	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
O3Y_04265	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
O3Y_04270	COG0110	maltose O-acetyltransferase activity
O3Y_04290	COG1045	serine acetyltransferase
O3Y_04300	COG0438	transferase activity, transferring glycosyl groups
O3Y_04310	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
O3Y_04340	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
O3Y_04350	COG1596	polysaccharide export
O3Y_04375	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
O3Y_04385	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
O3Y_04390	COG0321	lipoyl(octanoyl) transferase activity
O3Y_04395	COG2921	Belongs to the UPF0250 family
O3Y_04400	COG1686	Belongs to the peptidase S11 family
O3Y_04405	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
O3Y_04410	COG0772	Belongs to the SEDS family
O3Y_04415	COG0768	penicillin binding
O3Y_04420	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
O3Y_04425	COG0799	negative regulation of ribosome biogenesis
O3Y_04430	COG1466	dna polymerase III delta subunit
O3Y_04435	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
O3Y_04440	COG0495	leucyl-tRNA aminoacylation
O3Y_04445	COG2888	peptidyl-tyrosine sulfation
O3Y_04450	COG0815	Transfers the fatty acyl group on membrane lipoproteins
O3Y_04455	COG4535	Mg2 and Co2 transporter CorC
O3Y_04460	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
O3Y_04465	COG1702	phosphate starvation-inducible protein PhoH
O3Y_04470	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O3Y_04475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O3Y_04480	COG2190	(PTS) system
O3Y_04490	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O3Y_04495	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
O3Y_04500	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
O3Y_04505	COG3115	cell septum assembly
O3Y_04510	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
O3Y_04525	COG0789	Transcriptional regulator
O3Y_04530	COG1585	Membrane protein implicated in regulation of membrane protease activity
O3Y_04535	COG0330	HflC and HflK could
O3Y_04540	COG3118	belongs to the thioredoxin family
O3Y_04545	COG0300	oxidoreductase activity
O3Y_04550	COG1090	epimerase
O3Y_04555	COG0622	Phosphoesterase
O3Y_04570	COG3710	Transcriptional regulator
O3Y_04575	COG0326	Molecular chaperone. Has ATPase activity
O3Y_04580	COG0563	adenylate kinase activity
O3Y_04585	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
O3Y_04600	COG0367	asparagine synthase
O3Y_04605	COG4651	solute:proton antiporter activity
O3Y_04605	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
O3Y_04610	COG1846	Transcriptional regulator
O3Y_04610	COG1940	carbohydrate kinase activity
O3Y_04615	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
O3Y_04620	COG1263	PTS System
O3Y_04620	COG2190	(PTS) system
O3Y_04620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O3Y_04625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O3Y_04635	COG0101	tRNA pseudouridine synthase activity
O3Y_04640	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
O3Y_04645	COG0285	dihydrofolate synthase activity
O3Y_04650	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
O3Y_04655	COG1286	toxin biosynthetic process
O3Y_04660	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
O3Y_04665	COG2056	Na+-H+ antiporter family
O3Y_04670	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
O3Y_04690	COG0346	lactoylglutathione lyase activity
O3Y_04695	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
O3Y_04700	COG4660	Part of a membrane complex involved in electron transport
O3Y_04705	COG4659	FMN binding
O3Y_04710	COG4658	electron transport chain
O3Y_04715	COG4656	Part of a membrane complex involved in electron transport
O3Y_04720	COG2878	Part of a membrane complex involved in electron transport
O3Y_04725	COG4657	Part of a membrane complex involved in electron transport
O3Y_04730	COG0556	nucleotide-excision repair
O3Y_04735	COG2204	response regulator
O3Y_04740	COG2198	Histidine kinase
O3Y_04745	COG0391	Required for morphogenesis under gluconeogenic growth conditions
O3Y_04750	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
O3Y_04755	COG0521	Mo-molybdopterin cofactor biosynthetic process
O3Y_04760	COG0315	cyclic pyranopterin monophosphate synthase activity
O3Y_04765	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
O3Y_04770	COG0314	molybdopterin synthase activity
O3Y_04775	COG2199	diguanylate cyclase activity
O3Y_04780	COG4109	DRTGG domain
O3Y_04790	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
O3Y_04800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O3Y_04800	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O3Y_04805	COG0489	protein tyrosine kinase activity
O3Y_04815	COG0572	uridine kinase
O3Y_04820	COG2982	Protein involved in outer membrane biogenesis
O3Y_04825	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
O3Y_04830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O3Y_04840	COG2067	long-chain fatty acid transport protein
O3Y_04855	COG0183	Belongs to the thiolase family
O3Y_04860	COG1024	Enoyl-CoA hydratase
O3Y_04860	COG1250	3-hydroxyacyl-CoA dehydrogenase
O3Y_04865	COG0778	Nitroreductase
O3Y_04870	COG0583	DNA-binding transcription factor activity
O3Y_04875	COG0745	RESPONSE REGULATOR receiver
O3Y_04890	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O3Y_04900	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
O3Y_04905	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
O3Y_04920	COG1028	Short-chain dehydrogenase reductase Sdr
O3Y_04925	COG0616	signal peptide processing
O3Y_04935	COG1522	sequence-specific DNA binding
O3Y_04940	COG1946	Acyl-CoA thioesterase
O3Y_04960	COG3706	GGDEF domain
O3Y_04970	COG0640	Transcriptional regulator
O3Y_04975	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O3Y_05000	COG1881	PFAM PEBP family protein
O3Y_05020	COG0009	L-threonylcarbamoyladenylate synthase
O3Y_05035	COG2201	protein-glutamate methylesterase activity
O3Y_05045	COG5002	protein histidine kinase activity
O3Y_05050	COG4191	Histidine kinase
O3Y_05055	COG3300	MHYT domain
O3Y_05055	COG5001	Diguanylate cyclase
O3Y_05060	COG2204	response regulator
O3Y_05080	COG0601	transmembrane transport
O3Y_05085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O3Y_05090	COG0444	Belongs to the ABC transporter superfamily
O3Y_05095	COG4608	Belongs to the ABC transporter superfamily
O3Y_05100	COG0435	Glutathione S-transferase
O3Y_05105	COG0857	belongs to the CobB CobQ family
O3Y_05105	COG0280	phosphate acetyltransferase
O3Y_05110	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
O3Y_05115	COG3092	negative regulation of chromosome organization
O3Y_05120	COG4628	conserved protein (DUF2132)
O3Y_05130	COG4120	Belongs to the binding-protein-dependent transport system permease family
O3Y_05140	COG2199	diguanylate cyclase activity
O3Y_05140	COG2203	Gaf domain
O3Y_05145	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O3Y_05155	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
O3Y_05160	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
O3Y_05165	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
O3Y_05170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
O3Y_05175	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
O3Y_05180	COG0156	8-amino-7-oxononanoate synthase activity
O3Y_05185	COG2226	methyltransferase
O3Y_05190	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
O3Y_05200	COG0501	Belongs to the peptidase M48B family
O3Y_05210	COG0300	oxidoreductase activity
O3Y_05225	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
O3Y_05235	COG2268	Band 7 protein
O3Y_05245	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
O3Y_05250	COG2915	High frequency lysogenization protein hflD homolog
O3Y_05255	COG0482	sulfurtransferase activity
O3Y_05260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O3Y_05265	COG2916	Histone family protein nucleoid-structuring protein H-NS
O3Y_05270	COG1757	Na H antiporter
O3Y_05275	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
O3Y_05280	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
O3Y_05285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
O3Y_05290	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
O3Y_05290	COG0131	Imidazoleglycerol-phosphate dehydratase
O3Y_05295	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
O3Y_05300	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
O3Y_05305	COG0107	imidazoleglycerol-phosphate synthase activity
O3Y_05310	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
O3Y_05310	COG0140	phosphoribosyl-ATP diphosphatase activity
O3Y_05315	COG1187	pseudouridine synthase activity
O3Y_05325	COG1278	Cold shock
O3Y_05330	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
O3Y_05335	COG0542	response to heat
O3Y_05345	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
O3Y_05350	COG1012	belongs to the aldehyde dehydrogenase family
O3Y_05350	COG1454	alcohol dehydrogenase
O3Y_05355	COG1737	Transcriptional regulator
O3Y_05360	COG0076	glutamate decarboxylase activity
O3Y_05370	COG2431	L-lysine efflux transmembrane transporter activity
O3Y_05380	COG3070	regulator of competence-specific genes
O3Y_05395	COG3852	Histidine kinase
O3Y_05405	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
O3Y_05420	COG0189	ligase activity
O3Y_05420	COG4067	protein conserved in archaea
O3Y_05425	COG0500	methyltransferase
O3Y_05430	COG4106	trans-aconitate 2-methyltransferase activity
O3Y_05435	COG1801	Protein of unknown function DUF72
O3Y_05440	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
O3Y_05445	COG1435	thymidine kinase activity
O3Y_05455	COG0159	tryptophan synthase activity
O3Y_05460	COG0133	tryptophan synthase activity
O3Y_05465	COG0135	phosphoribosylanthranilate isomerase activity
O3Y_05465	COG0134	indole-3-glycerol-phosphate synthase activity
O3Y_05470	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
O3Y_05475	COG0512	Glutamine amidotransferase of anthranilate synthase
O3Y_05480	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
O3Y_05490	COG0613	PHP domain protein
O3Y_05495	COG0009	L-threonylcarbamoyladenylate synthase
O3Y_05500	COG1187	pseudouridine synthase activity
O3Y_05505	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
O3Y_05510	COG4988	ABC transporter
O3Y_05515	COG0492	ferredoxin-NADP+ reductase activity
O3Y_05525	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
O3Y_05530	COG3706	GGDEF domain
O3Y_05535	COG2949	membrane
O3Y_05545	COG0281	malic enzyme
O3Y_05555	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
O3Y_05575	COG2885	chlorophyll binding
O3Y_05590	COG0247	lactate metabolic process
O3Y_05590	COG0277	FAD linked oxidase domain protein
O3Y_05610	COG2986	histidine ammonia-lyase
O3Y_05615	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
O3Y_05620	COG0010	Belongs to the arginase family
O3Y_05625	COG1228	amidohydrolase
O3Y_05645	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
O3Y_05655	COG5001	Diguanylate cyclase
O3Y_05660	COG0417	DNA replication proofreading
O3Y_05665	COG2197	response regulator
O3Y_05670	COG0322	excinuclease ABC activity
O3Y_05680	COG3706	GGDEF domain
O3Y_05680	COG0745	RESPONSE REGULATOR receiver
O3Y_05690	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
O3Y_05695	COG0072	phenylalanine-tRNA ligase activity
O3Y_05695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O3Y_05700	COG0776	regulation of translation
O3Y_05715	COG0500	methyltransferase
O3Y_05730	COG0295	cytidine deaminase activity
O3Y_05735	COG1346	cytolysis
O3Y_05745	COG2925	Exonuclease
O3Y_05755	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O3Y_05760	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
O3Y_05765	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
O3Y_05780	COG2988	succinylglutamate desuccinylase activity
O3Y_05785	COG4139	cobalamin transport
O3Y_05790	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
O3Y_05830	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O3Y_05835	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O3Y_05840	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
O3Y_05860	COG2814	Major facilitator Superfamily
O3Y_05870	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O3Y_05895	COG2989	Protein conserved in bacteria
O3Y_05900	COG3108	Peptidase M15
O3Y_05905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O3Y_05920	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
O3Y_05945	COG1846	Transcriptional regulator
O3Y_05950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
O3Y_05955	COG0726	polysaccharide deacetylase
O3Y_05960	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O3Y_05970	COG1447	Phosphotransferase system cellobiose-specific component IIA
O3Y_05975	COG1486	melibiose metabolic process
O3Y_05980	COG3394	polysaccharide catabolic process
O3Y_05985	COG1609	Transcriptional regulator
O3Y_05990	COG2943	transferase activity, transferring hexosyl groups
O3Y_05995	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
O3Y_06000	COG0840	transmembrane signaling receptor activity
O3Y_06015	COG1448	Aminotransferase
O3Y_06030	COG0351	phosphomethylpyrimidine kinase
O3Y_06035	COG0017	Asparaginyl-tRNA synthetase
O3Y_06045	COG0720	synthase
O3Y_06050	COG1760	l-serine dehydratase
O3Y_06055	COG0814	amino acid
O3Y_06060	COG0494	nUDIX hydrolase
O3Y_06065	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
O3Y_06080	COG3106	COG3106 Predicted ATPase
O3Y_06085	COG3768	UPF0283 membrane protein
O3Y_06090	COG3283	Transcriptional regulator of aromatic amino acids metabolism
O3Y_06095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O3Y_06110	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
O3Y_06120	COG0471	metal ion transport
O3Y_06125	COG4191	Histidine kinase
O3Y_06125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O3Y_06135	COG2990	Protein conserved in bacteria
O3Y_06140	COG3713	MltA-interacting MipA family protein
O3Y_06145	COG2205	protein histidine kinase activity
O3Y_06150	COG0745	RESPONSE REGULATOR receiver
O3Y_06175	COG1129	ABC transporter
O3Y_06210	COG2186	Transcriptional regulator
O3Y_06215	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
O3Y_06220	COG0372	Belongs to the citrate synthase family
O3Y_06250	COG2195	Cleaves the N-terminal amino acid of tripeptides
O3Y_06260	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
O3Y_06270	COG0625	glutathione transferase activity
O3Y_06275	COG3437	response regulator, receiver
O3Y_06290	COG3706	GGDEF domain
O3Y_06295	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
O3Y_06300	COG1254	Belongs to the acylphosphatase family
O3Y_06305	COG2920	part of a sulfur-relay system
O3Y_06310	COG0670	Belongs to the BI1 family
O3Y_06315	COG1126	abc transporter atp-binding protein
O3Y_06320	COG0765	amino acid transport
O3Y_06325	COG4597	amino acid ABC transporter
O3Y_06330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O3Y_06340	COG0561	phosphatase activity
O3Y_06345	COG0602	queuosine metabolic process
O3Y_06350	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
O3Y_06380	COG3706	GGDEF domain
O3Y_06385	COG0443	Heat shock 70 kDa protein
O3Y_06390	COG0443	Heat shock 70 kDa protein
O3Y_06420	COG1643	Atp-dependent helicase
O3Y_06430	COG0443	Heat shock 70 kDa protein
O3Y_06435	COG0095	Lipoate-protein ligase
O3Y_06445	COG0583	DNA-binding transcription factor activity
O3Y_06450	COG0477	Major facilitator Superfamily
O3Y_06455	COG0415	Belongs to the DNA photolyase family
O3Y_06460	COG2076	Multidrug Resistance protein
O3Y_06480	COG0643	Histidine kinase
O3Y_06480	COG2198	Histidine kinase
O3Y_06490	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
O3Y_06500	COG2201	protein-glutamate methylesterase activity
O3Y_06505	COG0835	chemotaxis
O3Y_06510	COG0840	transmembrane signaling receptor activity
O3Y_06510	COG3290	protein histidine kinase activity
O3Y_06515	COG0840	transmembrane signaling receptor activity
O3Y_06525	COG0513	Belongs to the DEAD box helicase family
O3Y_06535	COG1538	Outer membrane efflux protein
O3Y_06540	COG1566	PFAM secretion protein HlyD family protein
O3Y_06545	COG2814	Major facilitator Superfamily
O3Y_06550	COG0840	transmembrane signaling receptor activity
O3Y_06555	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
O3Y_06565	COG3501	Rhs element vgr protein
O3Y_06590	COG1280	lysine exporter protein (LysE YggA)
O3Y_06595	COG1115	amino acid carrier protein
O3Y_06610	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
O3Y_06615	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
O3Y_06620	COG1177	transmembrane transport
O3Y_06625	COG1176	ABC-type spermidine putrescine transport system, permease component I
O3Y_06630	COG3842	ATPase activity
O3Y_06650	COG0037	tRNA processing
O3Y_06655	COG0589	response to stress
O3Y_06660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O3Y_06675	COG2217	Heavy metal translocating P-type atpase
O3Y_06685	COG2010	Cytochrome c
O3Y_06700	COG3278	Belongs to the heme-copper respiratory oxidase family
O3Y_06715	COG0784	Response regulator, receiver
O3Y_06715	COG2205	protein histidine kinase activity
O3Y_06740	COG2994	toxin metabolic process
O3Y_06745	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
O3Y_06745	COG3064	Membrane
O3Y_06745	COG1073	alpha beta
O3Y_06765	COG1476	TRANSCRIPTIONal
O3Y_06780	COG4128	Pfam Zonular occludens toxin
O3Y_06815	COG1476	TRANSCRIPTIONal
O3Y_06900	COG3120	sequence-specific DNA binding
O3Y_06905	COG1067	ATP-dependent peptidase activity
O3Y_06910	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
O3Y_06935	COG0116	Belongs to the methyltransferase superfamily
O3Y_06935	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
O3Y_06945	COG0167	dihydroorotate dehydrogenase activity
O3Y_06960	COG0308	aminopeptidase N
O3Y_06995	COG0641	radical SAM
O3Y_07075	COG4695	Portal protein
O3Y_07175	COG1428	Deoxynucleoside kinase
O3Y_07250	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
O3Y_07255	COG0308	aminopeptidase N
O3Y_07270	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
O3Y_07275	COG1956	GAF domain-containing protein
O3Y_07280	COG1132	(ABC) transporter
O3Y_07285	COG2995	paraquat-inducible protein a
O3Y_07290	COG3008	intermembrane lipid transfer
O3Y_07295	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
O3Y_07295	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
O3Y_07300	COG2996	Protein conserved in bacteria
O3Y_07315	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
O3Y_07325	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
O3Y_07340	COG0437	4 iron, 4 sulfur cluster binding
O3Y_07345	COG0243	molybdopterin cofactor binding
O3Y_07345	COG3383	formate dehydrogenase (NAD+) activity
O3Y_07375	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
O3Y_07380	COG0488	(ABC) transporter
O3Y_07385	COG3852	Histidine kinase
O3Y_07390	COG2204	response regulator
O3Y_07400	COG4662	Binding-protein-dependent transport system inner membrane component
O3Y_07405	COG3842	ATPase activity
O3Y_07410	COG0746	molybdenum cofactor guanylyltransferase activity
O3Y_07440	COG1940	carbohydrate kinase activity
O3Y_07455	COG0840	transmembrane signaling receptor activity
O3Y_07460	COG0791	NLP P60 protein
O3Y_07480	COG0534	Mate efflux family protein
O3Y_07490	COG1793	dna ligase
O3Y_07500	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
O3Y_07505	COG0848	biopolymer transport protein
O3Y_07510	COG0811	peptide transport
O3Y_07515	COG0811	peptide transport
O3Y_07530	COG1175	transmembrane transport
O3Y_07535	COG0395	ABC-type sugar transport system, permease component
O3Y_07540	COG3842	ATPase activity
O3Y_07545	COG1349	DNA-binding transcription factor activity
O3Y_07550	COG0584	glycerophosphoryl diester phosphodiesterase
O3Y_07555	COG2731	YhcH YjgK YiaL family protein
O3Y_07560	COG0251	oxidation-reduction process
O3Y_07565	COG1609	Transcriptional regulator
O3Y_07570	COG2723	6-phospho-beta-galactosidase activity
O3Y_07575	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
O3Y_07580	COG0583	DNA-binding transcription factor activity
O3Y_07600	COG1136	(ABC) transporter
O3Y_07600	COG0577	efflux transmembrane transporter activity
O3Y_07605	COG0577	efflux transmembrane transporter activity
O3Y_07605	COG1136	(ABC) transporter
O3Y_07610	COG1136	(ABC) transporter
O3Y_07610	COG0577	efflux transmembrane transporter activity
O3Y_07615	COG1294	oxidase, subunit
O3Y_07620	COG1271	oxidase subunit
O3Y_07660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O3Y_07670	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
O3Y_07690	COG0753	catalase activity
O3Y_07705	COG3527	Alpha-acetolactate decarboxylase
O3Y_07720	COG2199	diguanylate cyclase activity
O3Y_07720	COG2200	EAL domain
O3Y_07725	COG3706	GGDEF domain
O3Y_07730	COG2017	converts alpha-aldose to the beta-anomer
O3Y_07735	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
O3Y_07740	COG1085	galactose-1-phosphate uridylyltransferase
O3Y_07755	COG0745	RESPONSE REGULATOR receiver
O3Y_07755	COG3706	GGDEF domain
O3Y_07770	COG0835	chemotaxis
O3Y_07770	COG0784	Response regulator, receiver
O3Y_07780	COG4565	transcriptional regulatory protein
O3Y_07785	COG3290	protein histidine kinase activity
O3Y_07800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O3Y_07820	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
O3Y_07825	COG3063	Type IV pilus biogenesis stability protein PilW
O3Y_07840	COG1451	nucleotide metabolic process
O3Y_07850	COG0583	DNA-binding transcription factor activity
O3Y_07875	COG1538	Outer membrane efflux protein
O3Y_07885	COG0019	diaminopimelate decarboxylase activity
O3Y_07890	COG1748	Saccharopine dehydrogenase
O3Y_07900	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
O3Y_07915	COG4181	ATPase activity
O3Y_07920	COG0534	Mate efflux family protein
O3Y_07925	COG0702	epimerase
O3Y_07935	COG2814	Major facilitator Superfamily
O3Y_07940	COG1187	pseudouridine synthase activity
O3Y_07945	COG1061	Type III restriction enzyme res subunit
O3Y_07965	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
O3Y_07970	COG2203	Gaf domain
O3Y_07970	COG3706	GGDEF domain
O3Y_07970	COG4251	negative regulation of phosphorylation
O3Y_07970	COG5001	Diguanylate cyclase
O3Y_07985	COG0840	transmembrane signaling receptor activity
O3Y_08015	COG4934	collagen metabolic process
O3Y_08035	COG2239	Acts as a magnesium transporter
O3Y_08050	COG0814	amino acid
O3Y_08055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O3Y_08060	COG1131	(ABC) transporter
O3Y_08065	COG0842	Transport permease protein
O3Y_08075	COG3313	Fe-S protein
O3Y_08085	COG4134	Bacterial extracellular solute-binding protein
O3Y_08090	COG4135	transport system, permease component
O3Y_08095	COG4136	ATPase activity
O3Y_08100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
O3Y_08105	COG0564	pseudouridine synthase activity
O3Y_08110	COG0733	neurotransmitter:sodium symporter activity
O3Y_08120	COG0626	cystathionine gamma-synthase activity
O3Y_08125	COG2818	Glycosylase
O3Y_08140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O3Y_08155	COG1842	Phage shock protein A
O3Y_08160	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
O3Y_08170	COG4168	peptide transport system, permease
O3Y_08175	COG4171	peptide transport system, permease
O3Y_08185	COG4172	Belongs to the ABC transporter superfamily
O3Y_08200	COG1227	inorganic diphosphatase activity
O3Y_08220	COG0243	molybdopterin cofactor binding
O3Y_08225	COG3005	denitrification pathway
O3Y_08230	COG4459	periplasmic nitrate reductase
O3Y_08240	COG2116	formate transmembrane transporter activity
O3Y_08250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O3Y_08255	COG1434	Gram-negative-bacterium-type cell wall biogenesis
O3Y_08265	COG2917	probably involved in intracellular septation
O3Y_08270	COG1607	acyl-coa hydrolase
O3Y_08275	COG2350	Protein conserved in bacteria
O3Y_08285	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
O3Y_08290	COG0583	DNA-binding transcription factor activity
O3Y_08305	COG0612	Peptidase, M16
O3Y_08315	COG1032	radical SAM domain protein
O3Y_08330	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
O3Y_08335	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
O3Y_08340	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
O3Y_08345	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
O3Y_08350	COG1434	Gram-negative-bacterium-type cell wall biogenesis
O3Y_08355	COG0745	RESPONSE REGULATOR receiver
O3Y_08360	COG3381	protein complex oligomerization
O3Y_08365	COG1609	Transcriptional regulator
O3Y_08370	COG3070	regulator of competence-specific genes
O3Y_08390	COG0297	glycogen (starch) synthase activity
O3Y_08395	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
O3Y_08400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O3Y_08410	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
O3Y_08420	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
O3Y_08425	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
O3Y_08430	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
O3Y_08435	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
O3Y_08460	COG1012	belongs to the aldehyde dehydrogenase family
O3Y_08465	COG1309	transcriptional regulator
O3Y_08485	COG0668	transmembrane transport
O3Y_08490	COG2995	paraquat-inducible protein a
O3Y_08495	COG3008	intermembrane lipid transfer
O3Y_08495	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
O3Y_08505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O3Y_08515	COG0582	viral genome integration into host DNA
O3Y_08520	COG0582	viral genome integration into host DNA
O3Y_08525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O3Y_08545	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
O3Y_08565	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
O3Y_08585	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
O3Y_08590	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
O3Y_08595	COG1737	Transcriptional regulator
O3Y_08600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O3Y_08605	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
O3Y_08610	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
O3Y_08615	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
O3Y_08620	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
O3Y_08625	COG1940	carbohydrate kinase activity
O3Y_08630	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
O3Y_08635	COG4409	exo-alpha-(2->6)-sialidase activity
O3Y_08645	COG2003	Belongs to the UPF0758 family
O3Y_08670	COG3941	tape measure
O3Y_08715	COG0488	(ABC) transporter
O3Y_08800	COG0415	Belongs to the DNA photolyase family
O3Y_08810	COG4628	conserved protein (DUF2132)
O3Y_08815	COG3284	Transcriptional regulator
O3Y_08820	COG1012	belongs to the aldehyde dehydrogenase family
O3Y_08830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O3Y_08835	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O3Y_08840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O3Y_08850	COG2207	Transcriptional regulator
O3Y_08855	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O3Y_08855	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O3Y_08855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O3Y_08860	COG1482	cell wall glycoprotein biosynthetic process
O3Y_08870	COG5002	protein histidine kinase activity
O3Y_08870	COG0784	Response regulator, receiver
O3Y_08880	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
O3Y_08890	COG2885	chlorophyll binding
O3Y_08895	COG0823	Involved in the tonB-independent uptake of proteins
O3Y_08910	COG0811	peptide transport
O3Y_08915	COG0824	Thioesterase
O3Y_08920	COG3790	cyd operon protein YbgE
O3Y_08925	COG4890	Cyd operon protein YbgT
O3Y_08930	COG1294	oxidase, subunit
O3Y_08935	COG1271	oxidase subunit
O3Y_08940	COG2255	four-way junction helicase activity
O3Y_08945	COG0632	four-way junction helicase activity
O3Y_08950	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
O3Y_08955	COG0215	cysteine-tRNA ligase activity
O3Y_08960	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
O3Y_08965	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O3Y_08970	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
O3Y_08980	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
O3Y_08985	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
O3Y_08990	COG1199	ATP-dependent helicase activity
O3Y_08995	COG0730	response to heat
O3Y_09000	COG3923	Primosomal replication protein n
O3Y_09010	COG0840	transmembrane signaling receptor activity
O3Y_09015	COG0708	Exodeoxyribonuclease III
O3Y_09020	COG4160	amino acid transport
O3Y_09025	COG4215	(ABC) transporter
O3Y_09045	COG1882	Formate acetyltransferase
O3Y_09055	COG0840	transmembrane signaling receptor activity
O3Y_09060	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
O3Y_09070	COG3013	Belongs to the UPF0304 family
O3Y_09075	COG2766	serine protein kinase
O3Y_09080	COG2718	Belongs to the UPF0229 family
O3Y_09085	COG2719	SpoVR family
O3Y_09090	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
O3Y_09100	COG1663	tetraacyldisaccharide 4'-kinase activity
O3Y_09105	COG1132	(ABC) transporter
O3Y_09110	COG0658	competence protein
O3Y_09110	COG2333	competence protein COMEC
O3Y_09120	COG4591	ABC-type transport system involved in lipoprotein release permease component
O3Y_09125	COG1136	(ABC) transporter
O3Y_09130	COG4591	ABC-type transport system involved in lipoprotein release permease component
O3Y_09140	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
O3Y_09160	COG1252	NADH dehydrogenase
O3Y_09190	COG0537	adenosine 5'-monophosphoramidase activity
O3Y_09205	COG2186	Transcriptional regulator
O3Y_09210	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
O3Y_09215	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
O3Y_09220	COG1674	ftsk spoiiie
O3Y_09230	COG0686	Belongs to the AlaDH PNT family
O3Y_09240	COG0583	DNA-binding transcription factor activity
O3Y_09255	COG0284	orotidine-5'-phosphate decarboxylase activity
O3Y_09260	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
O3Y_09265	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
O3Y_09270	COG0776	regulation of translation
O3Y_09275	COG0539	negative regulation of cytoplasmic translation
O3Y_09280	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
O3Y_09285	COG1555	photosystem II stabilization
O3Y_09290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O3Y_09295	COG0776	regulation of translation
O3Y_09300	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
O3Y_09305	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
O3Y_09315	COG0544	peptidyl-prolyl cis-trans isomerase activity
O3Y_09320	COG4191	Histidine kinase
O3Y_09330	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
O3Y_09335	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
O3Y_09340	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
O3Y_09345	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
O3Y_09360	COG3300	MHYT domain
O3Y_09360	COG5001	Diguanylate cyclase
O3Y_09370	COG4589	Belongs to the CDS family
O3Y_09400	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
O3Y_09410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O3Y_09425	COG0243	molybdopterin cofactor binding
O3Y_09430	COG3005	denitrification pathway
O3Y_09435	COG3325	Belongs to the glycosyl hydrolase 18 family
O3Y_09435	COG3469	chitinase activity
O3Y_09440	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
O3Y_09450	COG2951	lytic endotransglycosylase activity
O3Y_09455	COG3100	YcgL domain-containing protein
O3Y_09460	COG0850	regulation of cytokinetic process
O3Y_09465	COG2894	cell division
O3Y_09470	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
O3Y_09475	COG3015	lipoprotein NlpE involved in copper resistance
O3Y_09495	COG0477	Major facilitator Superfamily
O3Y_09505	COG0840	transmembrane signaling receptor activity
O3Y_09510	COG1396	sequence-specific DNA binding
O3Y_09515	COG3135	benzoate transporter
O3Y_09525	COG1441	menaquinone biosynthetic process
O3Y_09535	COG0596	Alpha beta hydrolase
O3Y_09540	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
O3Y_09545	COG1169	isochorismate synthase
O3Y_09550	COG0436	Aminotransferase
O3Y_09555	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
O3Y_09560	COG0232	Belongs to the dGTPase family. Type 2 subfamily
O3Y_09580	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
O3Y_09585	COG0318	PFAM AMP-dependent synthetase and ligase
O3Y_09590	COG0596	Alpha beta hydrolase
O3Y_09605	COG1214	PFAM Peptidase M22, glycoprotease
O3Y_09610	COG1199	ATP-dependent helicase activity
O3Y_09620	COG0788	formyltetrahydrofolate deformylase activity
O3Y_09625	COG1902	pentaerythritol trinitrate reductase activity
O3Y_09625	COG0446	pyridine nucleotide-disulphide oxidoreductase
O3Y_09630	COG0616	signal peptide processing
O3Y_09635	COG0252	asparaginase activity
O3Y_09640	COG3139	Protein of unknown function (DUF1315)
O3Y_09650	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O3Y_09655	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O3Y_09660	COG0676	glucose-6-phosphate 1-epimerase activity
O3Y_09670	COG2226	methyltransferase
O3Y_09685	COG0835	chemotaxis
O3Y_09685	COG0784	Response regulator, receiver
O3Y_09690	COG1940	carbohydrate kinase activity
O3Y_09700	COG4667	esterase of the alpha-beta hydrolase superfamily
O3Y_09715	COG0733	neurotransmitter:sodium symporter activity
O3Y_09725	COG1263	PTS System
O3Y_09725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O3Y_09730	COG0084	hydrolase, TatD family'
O3Y_09740	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
O3Y_09745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
O3Y_09750	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O3Y_09755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O3Y_09760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O3Y_09765	COG1028	Short-chain dehydrogenase reductase Sdr
O3Y_09770	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
O3Y_09775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O3Y_09780	COG0416	fatty acid biosynthetic process
O3Y_09785	COG0333	Belongs to the bacterial ribosomal protein bL32 family
O3Y_09790	COG1399	metal-binding, possibly nucleic acid-binding protein
O3Y_09795	COG0424	maF-like protein
O3Y_09800	COG0564	pseudouridine synthase activity
O3Y_09810	COG1530	ribonuclease E activity
O3Y_09815	COG0659	secondary active sulfate transmembrane transporter activity
O3Y_09825	COG1454	alcohol dehydrogenase
O3Y_09825	COG1012	belongs to the aldehyde dehydrogenase family
O3Y_09830	COG2095	MarC family integral membrane protein
O3Y_09835	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
O3Y_09840	COG1757	Na H antiporter
O3Y_09850	COG3081	Nucleoid-associated protein
O3Y_09860	COG3083	sulfuric ester hydrolase activity
O3Y_09865	COG0123	including yeast histone deacetylase and acetoin utilization protein
O3Y_09870	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O3Y_09875	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
O3Y_09895	COG2853	Lipoprotein
O3Y_09905	COG3088	subunit of a heme lyase
O3Y_09905	COG4235	cytochrome complex assembly
O3Y_09910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O3Y_09915	COG1138	Cytochrome C-type biogenesis protein
O3Y_09920	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
O3Y_09930	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O3Y_09935	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O3Y_09940	COG4133	protoheme IX ABC transporter activity
O3Y_09950	COG0835	chemotaxis
O3Y_09960	COG1192	Involved in chromosome partitioning
O3Y_09965	COG2201	protein-glutamate methylesterase activity
O3Y_09970	COG0643	Histidine kinase
O3Y_09970	COG2198	Histidine kinase
O3Y_09975	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
O3Y_09990	COG0455	bacterial-type flagellum organization
O3Y_10005	COG2062	phosphohistidine phosphatase, SixA
O3Y_10010	COG1025	Belongs to the peptidase M16 family
O3Y_10020	COG0018	arginyl-trna synthetase
O3Y_10040	COG1918	ferrous iron import across plasma membrane
O3Y_10045	COG4977	sequence-specific DNA binding
O3Y_10050	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
O3Y_10055	COG1121	(ABC) transporter
O3Y_10060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O3Y_10070	COG0045	succinate-CoA ligase (ADP-forming) activity
O3Y_10075	COG0508	dehydrogenase complex catalyzes the overall conversion of
O3Y_10080	COG0567	Dehydrogenase, E1 component
O3Y_10090	COG1053	succinate dehydrogenase
O3Y_10095	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
O3Y_10100	COG2009	succinate dehydrogenase
O3Y_10105	COG0372	Belongs to the citrate synthase family
O3Y_10110	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
O3Y_10120	COG0033	Phosphoglucomutase
O3Y_10125	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
O3Y_10130	COG0596	Alpha beta hydrolase
O3Y_10145	COG1346	cytolysis
O3Y_10155	COG0583	DNA-binding transcription factor activity
O3Y_10165	COG0735	belongs to the Fur family
O3Y_10170	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
O3Y_10175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O3Y_10180	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O3Y_10185	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
O3Y_10185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O3Y_10190	COG0431	NADPH-dependent FMN reductase
O3Y_10200	COG3101	peptidyl-lysine hydroxylation
O3Y_10205	COG2860	membrane
O3Y_10210	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
O3Y_10215	COG2890	protein-(glutamine-N5) methyltransferase activity
O3Y_10230	COG1684	flagellar biosynthetic protein fliR
O3Y_10235	COG1987	bacterial-type flagellum assembly
O3Y_10260	COG1580	Controls the rotational direction of flagella during chemotaxis
O3Y_10280	COG1317	bacterial-type flagellum organization
O3Y_10285	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
O3Y_10295	COG1677	Flagellar hook-basal body complex protein FliE
O3Y_10300	COG2204	response regulator
O3Y_10305	COG4191	Histidine kinase
O3Y_10310	COG2204	response regulator
O3Y_10315	COG1516	flagellar protein fliS
O3Y_10325	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
O3Y_10330	COG1334	flagellar protein FlaG
O3Y_10335	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O3Y_10340	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O3Y_10345	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O3Y_10350	COG2837	iron assimilation
O3Y_10370	COG1393	Belongs to the ArsC family
O3Y_10375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O3Y_10380	COG1876	peptidase activity
O3Y_10390	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
O3Y_10395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O3Y_10405	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
O3Y_10425	COG4783	chaperone-mediated protein folding
O3Y_10430	COG1393	Belongs to the ArsC family
O3Y_10450	COG2233	PERMEase
O3Y_10455	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
O3Y_10460	COG0737	Belongs to the 5'-nucleotidase family
O3Y_10465	COG2877	3-deoxy-8-phosphooctulonate synthase activity
O3Y_10470	COG2912	Transglutaminase-like superfamily
O3Y_10475	COG3094	Invasion gene expression up-regulator, SirB
O3Y_10480	COG2890	protein-(glutamine-N5) methyltransferase activity
O3Y_10485	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
O3Y_10490	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
O3Y_10495	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
O3Y_10500	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
O3Y_10505	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
O3Y_10510	COG0193	aminoacyl-tRNA hydrolase activity
O3Y_10515	COG0012	GTP binding
O3Y_10530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O3Y_10535	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O3Y_10550	COG3951	Flagellar rod assembly protein muramidase FlgJ
O3Y_10550	COG1705	Flagellar rod assembly protein muramidase FlgJ
O3Y_10555	COG1706	bacterial-type flagellum-dependent cell motility
O3Y_10560	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
O3Y_10565	COG4786	Flagellar basal body rod
O3Y_10570	COG4787	bacterial-type flagellum-dependent cell motility
O3Y_10575	COG1749	Flagellar hook protein flgE
O3Y_10580	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
O3Y_10585	COG1558	bacterial-type flagellum-dependent cell motility
O3Y_10590	COG1815	bacterial-type flagellum-dependent cell motility
O3Y_10595	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
O3Y_10600	COG0784	Response regulator, receiver
O3Y_10600	COG0835	chemotaxis
O3Y_10635	COG3433	isochorismatase activity
O3Y_10635	COG2226	methyltransferase
O3Y_10635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O3Y_10640	COG2375	cellular response to nickel ion
O3Y_10645	COG4774	siderophore transport
O3Y_10645	COG1629	transport
O3Y_10660	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O3Y_10665	COG2608	mercury ion transmembrane transporter activity
O3Y_10665	COG2217	Heavy metal translocating P-type atpase
O3Y_10680	COG3735	TraB family
O3Y_10690	COG2840	Smr protein MutS2
O3Y_10695	COG1187	pseudouridine synthase activity
O3Y_10700	COG3706	GGDEF domain
O3Y_10705	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
O3Y_10710	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
O3Y_10715	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
O3Y_10720	COG0121	glutamine amidotransferase
O3Y_10725	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
O3Y_10745	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
O3Y_10750	COG0328	RNA-DNA hybrid ribonuclease activity
O3Y_10755	COG2226	methyltransferase
O3Y_10760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O3Y_10765	COG1388	LysM domain
O3Y_10765	COG0741	lytic transglycosylase activity
O3Y_10775	COG0347	Belongs to the P(II) protein family
O3Y_10780	COG3479	Phenolic acid decarboxylase
O3Y_10790	COG0037	tRNA processing
O3Y_10795	COG0825	malonyl-CoA metabolic process
O3Y_10800	COG0587	DNA-directed DNA polymerase activity
O3Y_10805	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
O3Y_10810	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O3Y_10815	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O3Y_10820	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
O3Y_10825	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O3Y_10830	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
O3Y_10840	COG0750	zinc metalloprotease
O3Y_10845	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
O3Y_10850	COG0575	Belongs to the CDS family
O3Y_10855	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
O3Y_10860	COG0233	cytoplasmic translational termination
O3Y_10865	COG0528	UMP kinase activity
O3Y_10870	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
O3Y_10875	COG0052	Belongs to the universal ribosomal protein uS2 family
O3Y_10880	COG0024	Methionine aminopeptidase
O3Y_10885	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
O3Y_10895	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
O3Y_10900	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
O3Y_10905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
O3Y_10910	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
O3Y_10925	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O3Y_10925	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O3Y_10930	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
O3Y_10935	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
O3Y_10940	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
O3Y_10955	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
O3Y_10960	COG2252	PERMEase
O3Y_10965	COG2195	Cleaves the N-terminal amino acid of tripeptides
O3Y_10970	COG4067	protein conserved in archaea
O3Y_10970	COG0189	ligase activity
O3Y_10975	COG0189	ligase activity
O3Y_10985	COG0733	neurotransmitter:sodium symporter activity
O3Y_10990	COG3706	GGDEF domain
O3Y_11000	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
O3Y_11010	COG1477	protein flavinylation
O3Y_11015	COG2871	sodium ion transport
O3Y_11020	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
O3Y_11025	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
O3Y_11030	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
O3Y_11035	COG1805	sodium ion transport
O3Y_11040	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
O3Y_11045	COG0271	Belongs to the BolA IbaG family
O3Y_11050	COG2813	Specifically methylates the guanine in position
O3Y_11060	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
O3Y_11065	COG2211	Major facilitator Superfamily
O3Y_11075	COG1595	DNA-templated transcription, initiation
O3Y_11085	COG3248	Nucleoside-binding outer membrane protein
O3Y_11090	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
O3Y_11095	COG0693	protein deglycase activity
O3Y_11100	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
O3Y_11105	COG2166	iron-sulfur cluster assembly
O3Y_11110	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
O3Y_11115	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
O3Y_11125	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
O3Y_11125	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
O3Y_11135	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
O3Y_11140	COG1074	ATP-dependent DNA helicase activity
O3Y_11145	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
O3Y_11160	COG3141	response to X-ray
O3Y_11165	COG2171	N-acyltransferase activity
O3Y_11175	COG0456	acetyltransferase
O3Y_11180	COG0189	ligase activity
O3Y_11180	COG0569	domain protein
O3Y_11195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O3Y_11200	COG1609	Transcriptional regulator
O3Y_11205	COG3250	beta-galactosidase activity
O3Y_11220	COG1022	Amp-dependent synthetase and ligase
O3Y_11225	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
O3Y_11230	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
O3Y_11240	COG0560	Phosphoserine phosphatase
O3Y_11250	COG0813	purine-nucleoside phosphorylase activity
O3Y_11255	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
O3Y_11260	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
O3Y_11265	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
O3Y_11270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
O3Y_11275	COG0084	hydrolase, TatD family'
O3Y_11285	COG1115	amino acid carrier protein
O3Y_11300	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
O3Y_11305	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
O3Y_11310	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
O3Y_11315	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
O3Y_11320	COG0083	homoserine kinase activity
O3Y_11335	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
O3Y_11345	COG0745	RESPONSE REGULATOR receiver
O3Y_11350	COG5002	protein histidine kinase activity
O3Y_11350	COG2198	Histidine kinase
O3Y_11350	COG0784	Response regulator, receiver
O3Y_11355	COG5001	Diguanylate cyclase
O3Y_11355	COG2203	Gaf domain
O3Y_11355	COG3706	GGDEF domain
O3Y_11355	COG4251	negative regulation of phosphorylation
O3Y_11360	COG1242	4 iron, 4 sulfur cluster binding
O3Y_11365	COG0067	glutamate synthase
O3Y_11365	COG0069	glutamate synthase activity
O3Y_11365	COG0070	glutamate synthase
O3Y_11375	COG0070	glutamate synthase
O3Y_11375	COG0067	glutamate synthase
O3Y_11375	COG0069	glutamate synthase activity
O3Y_11380	COG0493	'glutamate synthase
O3Y_11390	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
O3Y_11400	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O3Y_11405	COG2860	membrane
O3Y_11410	COG0583	DNA-binding transcription factor activity
O3Y_11415	COG0730	response to heat
O3Y_11425	COG4172	Belongs to the ABC transporter superfamily
O3Y_11445	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
O3Y_11450	COG0505	Belongs to the CarA family
O3Y_11460	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
O3Y_11465	COG0494	nUDIX hydrolase
O3Y_11470	COG0653	protein targeting
O3Y_11480	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
O3Y_11485	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
O3Y_11490	COG0849	cell division
O3Y_11495	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
O3Y_11500	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
O3Y_11505	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
O3Y_11510	COG0772	Belongs to the SEDS family
O3Y_11515	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
O3Y_11520	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
O3Y_11525	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
O3Y_11530	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
O3Y_11535	COG0768	penicillin binding
O3Y_11540	COG3116	cell division
O3Y_11545	COG0275	rRNA processing
O3Y_11550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O3Y_11555	COG0508	dehydrogenase complex catalyzes the overall conversion of
O3Y_11560	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
O3Y_11565	COG2186	Transcriptional regulator
O3Y_11570	COG0737	Belongs to the 5'-nucleotidase family
O3Y_11575	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
O3Y_11580	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
O3Y_11585	COG4974	Belongs to the 'phage' integrase family
O3Y_11590	COG0716	FMN binding
O3Y_11610	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O3Y_11615	COG1459	type II secretion system
O3Y_11625	COG0237	dephospho-CoA kinase activity
O3Y_11630	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
O3Y_11640	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
O3Y_11645	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
O3Y_11650	COG0187	DNA topoisomerase II activity
O3Y_11655	COG3150	esterase
O3Y_11665	COG3151	Protein conserved in bacteria
O3Y_11670	COG0494	nUDIX hydrolase
O3Y_11675	COG1538	Outer membrane efflux protein
O3Y_11685	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
O3Y_11690	COG0840	transmembrane signaling receptor activity
O3Y_11695	COG3025	triphosphatase activity
O3Y_11700	COG1392	Phosphate transport regulator
O3Y_11705	COG0306	phosphate transporter
O3Y_11710	COG4991	sh3 domain protein
O3Y_11720	COG3267	Type II secretory pathway component ExeA
O3Y_11720	COG3409	Peptidoglycan-binding domain 1 protein
O3Y_11725	COG0617	tRNA 3'-terminal CCA addition
O3Y_11730	COG0148	phosphopyruvate hydratase activity
O3Y_11735	COG0504	CTP synthase activity
O3Y_11745	COG3956	TIGRFAM MazG family protein
O3Y_11750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O3Y_11755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O3Y_11765	COG5001	Diguanylate cyclase
O3Y_11780	COG0736	holo-[acyl-carrier-protein] synthase activity
O3Y_11785	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
O3Y_11790	COG1381	Involved in DNA repair and RecF pathway recombination
O3Y_11795	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
O3Y_11800	COG0571	ribonuclease III activity
O3Y_11805	COG0681	Belongs to the peptidase S26 family
O3Y_11810	COG0481	GTPase activity
O3Y_11815	COG3086	response to oxidative stress
O3Y_11820	COG3026	antisigma factor binding
O3Y_11830	COG1595	DNA-templated transcription, initiation
O3Y_11835	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
O3Y_11845	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
O3Y_11850	COG0354	folic acid binding
O3Y_11860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O3Y_11865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O3Y_11875	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
O3Y_11880	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
O3Y_11885	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
O3Y_11890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O3Y_11895	COG0440	acetolactate synthase activity
O3Y_11900	COG0028	Belongs to the TPP enzyme family
O3Y_11905	COG1022	Amp-dependent synthetase and ligase
O3Y_11910	COG0583	DNA-binding transcription factor activity
O3Y_11930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O3Y_11935	COG0473	3-isopropylmalate dehydrogenase activity
O3Y_11940	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
O3Y_11945	COG0066	3-isopropylmalate dehydratase activity
O3Y_11955	COG3437	response regulator, receiver
O3Y_11965	COG0795	lipopolysaccharide-transporting ATPase activity
O3Y_11970	COG0795	lipopolysaccharide-transporting ATPase activity
O3Y_11975	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
O3Y_11980	COG2927	DNA polymerase III (CHI subunit)
O3Y_11985	COG0525	valine-tRNA ligase activity
O3Y_11990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
O3Y_11995	COG0564	pseudouridine synthase activity
O3Y_12000	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O3Y_12010	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
O3Y_12015	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
O3Y_12025	COG0540	Belongs to the ATCase OTCase family
O3Y_12030	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
O3Y_12035	COG0251	oxidation-reduction process
O3Y_12040	COG0204	Acyl-transferase
O3Y_12045	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
O3Y_12050	COG5007	Belongs to the BolA IbaG family
O3Y_12060	COG2854	intermembrane phospholipid transfer
O3Y_12065	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
O3Y_12070	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
O3Y_12075	COG1127	ABC transporter
O3Y_12085	COG0517	IMP dehydrogenase activity
O3Y_12085	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
O3Y_12100	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
O3Y_12105	COG1137	ATPase activity
O3Y_12115	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
O3Y_12120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O3Y_12125	COG1660	Displays ATPase and GTPase activities
O3Y_12130	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O3Y_12135	COG2239	Acts as a magnesium transporter
O3Y_12140	COG0312	modulator of DNA gyrase
O3Y_12145	COG3028	Belongs to the UPF0307 family
O3Y_12150	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
O3Y_12155	COG1178	ABC-type Fe3 transport system permease component
O3Y_12160	COG4143	(ABC) transporter
O3Y_12165	COG0163	prenyltransferase activity
O3Y_12170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
O3Y_12175	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
O3Y_12180	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
O3Y_12185	COG2105	PFAM AIG2 family protein
O3Y_12195	COG0729	surface antigen
O3Y_12200	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O3Y_12205	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
O3Y_12220	COG1136	(ABC) transporter
O3Y_12240	COG0529	Catalyzes the synthesis of activated sulfate
O3Y_12245	COG2895	sulfate adenylyltransferase (ATP) activity
O3Y_12250	COG0175	sulfate reduction
O3Y_12255	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
O3Y_12255	COG1648	precorrin-2 dehydrogenase activity
O3Y_12260	COG0737	Belongs to the 5'-nucleotidase family
O3Y_12270	COG0513	Belongs to the DEAD box helicase family
O3Y_12275	COG2153	protein acetylation
O3Y_12280	COG0697	spore germination
O3Y_12285	COG3266	domain, Protein
O3Y_12285	COG3061	Opacity-associated protein A
O3Y_12290	COG0545	Peptidyl-prolyl cis-trans isomerase
O3Y_12300	COG0203	ribosomal protein L17
O3Y_12305	COG0202	RNA polymerase activity
O3Y_12310	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
O3Y_12315	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
O3Y_12320	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
O3Y_12330	COG0201	protein transport
O3Y_12335	COG0200	Binds to the 23S rRNA
O3Y_12340	COG1841	ribosomal large subunit assembly
O3Y_12345	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
O3Y_12350	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
O3Y_12355	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
O3Y_12360	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
O3Y_12365	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
O3Y_12370	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
O3Y_12375	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
O3Y_12380	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
O3Y_12385	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
O3Y_12390	COG0255	Belongs to the universal ribosomal protein uL29 family
O3Y_12395	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
O3Y_12400	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
O3Y_12405	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
O3Y_12410	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
O3Y_12415	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
O3Y_12420	COG0089	rRNA binding
O3Y_12425	COG0088	Forms part of the polypeptide exit tunnel
O3Y_12430	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
O3Y_12435	COG0051	transcription antitermination factor activity, RNA binding
O3Y_12440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O3Y_12445	COG0557	exoribonuclease II activity
O3Y_12450	COG3083	sulfuric ester hydrolase activity
O3Y_12455	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
O3Y_12460	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
O3Y_12470	COG1047	Peptidyl-prolyl cis-trans
O3Y_12485	COG2249	NAD(P)H dehydrogenase (quinone) activity
O3Y_12490	COG0488	(ABC) transporter
O3Y_12500	COG0429	hydrolase of the alpha beta-hydrolase fold
O3Y_12510	COG3954	Phosphoribulokinase
O3Y_12515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O3Y_12525	COG1012	belongs to the aldehyde dehydrogenase family
O3Y_12535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O3Y_12545	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O3Y_12560	COG0180	Tryptophanyl-tRNA synthetase
O3Y_12565	COG0546	phosphoglycolate phosphatase activity
O3Y_12570	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
O3Y_12575	COG0338	D12 class N6 adenine-specific DNA methyltransferase
O3Y_12585	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
O3Y_12590	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
O3Y_12620	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
O3Y_12630	COG0678	peroxiredoxin activity
O3Y_12630	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
O3Y_12635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O3Y_12645	COG0165	Argininosuccinate lyase
O3Y_12650	COG0137	argininosuccinate synthase activity
O3Y_12655	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
O3Y_12660	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
O3Y_12665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O3Y_12670	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
O3Y_12680	COG1045	serine acetyltransferase
O3Y_12685	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
O3Y_12690	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
O3Y_12695	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O3Y_12700	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
O3Y_12705	COG1053	succinate dehydrogenase
O3Y_12710	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
O3Y_12715	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
O3Y_12720	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
O3Y_12725	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
O3Y_12730	COG1509	lysine 2,3-aminomutase activity
O3Y_12740	COG0459	protein refolding
O3Y_12745	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
O3Y_12770	COG0149	triose-phosphate isomerase activity
O3Y_12780	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
O3Y_12785	COG1575	Belongs to the MenA family. Type 1 subfamily
O3Y_12790	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
O3Y_12795	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
O3Y_12800	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
O3Y_12805	COG1609	Transcriptional regulator
O3Y_12810	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
O3Y_12815	COG0254	rRNA binding
O3Y_12820	COG0281	malic enzyme
O3Y_12825	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
O3Y_12830	COG0626	cystathionine gamma-synthase activity
O3Y_12835	COG0460	homoserine dehydrogenase
O3Y_12835	COG0527	aspartate kinase activity
O3Y_12845	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
O3Y_12850	COG3074	FtsZ-dependent cytokinesis
O3Y_12855	COG1494	fructose-1,6-bisphosphatase
O3Y_12860	COG0205	6-phosphofructokinase activity
O3Y_12865	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
O3Y_12875	COG0745	RESPONSE REGULATOR receiver
O3Y_12880	COG2205	protein histidine kinase activity
O3Y_12890	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
O3Y_12895	COG3030	protein affecting phage T7 exclusion by the F plasmid
O3Y_12900	COG3706	GGDEF domain
O3Y_12905	COG1027	Aspartate ammonia-lyase
O3Y_12910	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
O3Y_12925	COG4232	protein-disulfide reductase activity
O3Y_12935	COG3263	regulation of cellular component size
O3Y_12945	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O3Y_12950	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
O3Y_12955	COG0194	GDP metabolic process
O3Y_12960	COG1758	RNA polymerase activity
O3Y_12965	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O3Y_12970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
O3Y_12975	COG2233	PERMEase
O3Y_12985	COG0745	RESPONSE REGULATOR receiver
O3Y_12990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O3Y_12995	COG2183	response to ionizing radiation
O3Y_13005	COG0596	Alpha beta hydrolase
O3Y_13010	COG1040	competence protein
O3Y_13015	COG0316	Belongs to the HesB IscA family
O3Y_13015	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
O3Y_13020	COG0494	nUDIX hydrolase
O3Y_13025	COG1218	3'(2'),5'-bisphosphate nucleotidase
O3Y_13035	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
O3Y_13040	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
O3Y_13045	COG3156	type II secretion system protein K
O3Y_13050	COG4795	General secretion pathway protein
O3Y_13055	COG2165	general secretion pathway protein
O3Y_13060	COG2165	general secretion pathway protein
O3Y_13065	COG2165	general secretion pathway protein
O3Y_13070	COG1459	type II secretion system
O3Y_13075	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O3Y_13085	COG3031	protein transport across the cell outer membrane
O3Y_13090	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
O3Y_13095	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
O3Y_13100	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
O3Y_13110	COG0456	acetyltransferase
O3Y_13115	COG1490	D-aminoacyl-tRNA deacylase activity
O3Y_13135	COG0174	glutamine synthetase
O3Y_13145	COG3852	Histidine kinase
O3Y_13155	COG3300	MHYT domain
O3Y_13155	COG5001	Diguanylate cyclase
O3Y_13160	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
O3Y_13170	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
O3Y_13175	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
O3Y_13180	COG1739	Uncharacterized protein family UPF0029
O3Y_13185	COG1024	Enoyl-CoA hydratase
O3Y_13185	COG1250	3-hydroxyacyl-CoA dehydrogenase
O3Y_13190	COG0183	Belongs to the thiolase family
O3Y_13195	COG0583	DNA-binding transcription factor activity
O3Y_13200	COG2814	Major facilitator Superfamily
O3Y_13205	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
O3Y_13210	COG0355	proton-transporting ATP synthase activity, rotational mechanism
O3Y_13215	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
O3Y_13220	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
O3Y_13225	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
O3Y_13230	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
O3Y_13235	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
O3Y_13245	COG0356	it plays a direct role in the translocation of protons across the membrane
O3Y_13250	COG3312	ion transport
O3Y_13255	COG1475	DNA binding
O3Y_13260	COG1192	Involved in chromosome partitioning
O3Y_13265	COG0357	Ribosomal RNA small subunit methyltransferase G
O3Y_13270	COG0445	tRNA wobble uridine modification
O3Y_13533	COG0217	transcriptional regulatory protein
O3Y_13538	COG2084	Dehydrogenase
O3Y_13553	COG2909	trisaccharide binding
O3Y_13558	COG0058	SHG alpha-glucan phosphorylase activity
O3Y_13563	COG1640	4-alpha-glucanotransferase
O3Y_13568	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
O3Y_13578	COG3501	Rhs element vgr protein
O3Y_13613	COG0471	metal ion transport
O3Y_13618	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
O3Y_13663	COG0671	phosphoesterase, PA-phosphatase related
O3Y_13668	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
O3Y_13678	COG1999	signal sequence binding
O3Y_13693	COG0786	glutamate:sodium symporter activity
O3Y_13713	COG1566	PFAM secretion protein HlyD family protein
O3Y_13723	COG3706	GGDEF domain
O3Y_13738	COG0813	purine-nucleoside phosphorylase activity
O3Y_13743	COG3272	Protein of unknown function (DUF1722)
O3Y_13753	COG0415	Belongs to the DNA photolyase family
O3Y_13758	COG1376	ErfK ybiS ycfS ynhG family protein
O3Y_13758	COG1388	LysM domain
O3Y_13768	COG0513	Belongs to the DEAD box helicase family
O3Y_13773	COG1770	oligopeptidase
O3Y_13803	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
O3Y_13808	COG0573	inorganic phosphate transmembrane transporter activity
O3Y_13813	COG0581	inorganic phosphate transmembrane transporter activity
O3Y_13818	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
O3Y_13838	COG0659	secondary active sulfate transmembrane transporter activity
O3Y_13848	COG0739	heme binding
O3Y_13853	COG3300	MHYT domain
O3Y_13853	COG5001	Diguanylate cyclase
O3Y_13858	COG0583	DNA-binding transcription factor activity
O3Y_13863	COG2814	Major facilitator Superfamily
O3Y_13888	COG1301	dicarboxylic acid transport
O3Y_13898	COG1342	Belongs to the UPF0251 family
O3Y_13928	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
O3Y_13933	COG0673	inositol 2-dehydrogenase activity
O3Y_13943	COG2200	EAL domain
O3Y_13943	COG2771	luxR family
O3Y_13948	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O3Y_13958	COG0564	pseudouridine synthase activity
O3Y_14053	COG3501	Rhs element vgr protein
O3Y_14068	COG1869	D-ribose catabolic process
O3Y_14073	COG1129	ABC transporter
O3Y_14078	COG1172	Belongs to the binding-protein-dependent transport system permease family
O3Y_14083	COG1879	ABC-type sugar transport system periplasmic component
O3Y_14088	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O3Y_14093	COG1609	Transcriptional regulator
O3Y_14103	COG3201	nicotinamide mononucleotide transporter
O3Y_14108	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
O3Y_14118	COG0584	glycerophosphoryl diester phosphodiesterase
O3Y_14123	COG2271	Major facilitator Superfamily
O3Y_14163	COG0579	oxidoreductase
O3Y_14173	COG0242	peptide deformylase activity
O3Y_14183	COG1320	monovalent cation:proton antiporter activity
O3Y_14188	COG2212	antiporter activity
O3Y_14208	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
O3Y_14208	COG2111	Na H antiporter
O3Y_14218	COG0589	response to stress
O3Y_14223	COG0814	amino acid
O3Y_14228	COG3033	Beta-eliminating lyase
O3Y_14233	COG3530	Putative quorum-sensing-regulated virulence factor
O3Y_14243	COG5001	Diguanylate cyclase
O3Y_14243	COG5002	protein histidine kinase activity
O3Y_14248	COG1278	Cold shock
O3Y_14263	COG2304	oxidoreductase activity
O3Y_14283	COG0714	Associated with various cellular activities
O3Y_14288	COG0840	transmembrane signaling receptor activity
O3Y_14308	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
O3Y_14313	COG2195	Cleaves the N-terminal amino acid of tripeptides
O3Y_14323	COG3604	Transcriptional regulator
O3Y_14328	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
O3Y_14328	COG1017	nitric oxide dioxygenase activity
O3Y_14333	COG1278	Cold shock
O3Y_14338	COG3036	rescue of stalled ribosome
O3Y_14368	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
O3Y_14368	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
O3Y_14373	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
O3Y_14383	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
O3Y_14393	COG0516	GMP reductase activity
O3Y_14423	COG1943	Transposase
O3Y_14428	COG0513	Belongs to the DEAD box helicase family
O3Y_14433	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
O3Y_14438	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
O3Y_14443	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
O3Y_14448	COG0784	Response regulator, receiver
O3Y_14448	COG3437	response regulator, receiver
O3Y_14453	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O3Y_14453	COG4191	Histidine kinase
O3Y_14463	COG1757	Na H antiporter
O3Y_14468	COG2814	Major facilitator Superfamily
O3Y_14478	COG3706	GGDEF domain
O3Y_14483	COG3240	lipase activity
O3Y_14493	COG0840	transmembrane signaling receptor activity
O3Y_14498	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
O3Y_14503	COG5380	lipid catabolic process
O3Y_14508	COG3291	Pkd domain containing protein
O3Y_14508	COG4412	M6 family metalloprotease domain protein
O3Y_14528	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O3Y_14533	COG4605	iron ion homeostasis
O3Y_14538	COG4604	ABC transporter, ATP-binding protein
O3Y_14558	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
O3Y_14578	COG0745	RESPONSE REGULATOR receiver
O3Y_14593	COG3623	hexulose-6-phosphate isomerase
O3Y_14598	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
O3Y_14603	COG0561	phosphatase activity
O3Y_14633	COG3038	cytochrome b561
O3Y_14638	COG0366	Alpha amylase catalytic
O3Y_14663	COG0745	RESPONSE REGULATOR receiver
O3Y_14668	COG5002	protein histidine kinase activity
O3Y_14693	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
O3Y_14708	COG2814	Major facilitator Superfamily
O3Y_14723	COG1686	Belongs to the peptidase S11 family
O3Y_14743	COG1943	Transposase
O3Y_14748	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
O3Y_14748	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
O3Y_14753	COG0509	glycine decarboxylation via glycine cleavage system
O3Y_14758	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
O3Y_14768	COG0404	The glycine cleavage system catalyzes the degradation of glycine
O3Y_14778	COG3039	Transposase
O3Y_14803	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
O3Y_14813	COG0291	Belongs to the bacterial ribosomal protein bL35 family
O3Y_14818	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
O3Y_14873	COG1028	Short-chain dehydrogenase reductase Sdr
O3Y_14913	COG0232	Belongs to the dGTPase family. Type 2 subfamily
O3Y_14938	COG0494	nUDIX hydrolase
O3Y_14953	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O3Y_14958	COG3040	lipid binding
O3Y_14988	COG3041	Addiction module toxin RelE StbE family
O3Y_15053	COG1619	proteins homologs of microcin C7 resistance protein MccF
O3Y_15098	COG0346	lactoylglutathione lyase activity
O3Y_15113	COG3040	lipid binding
O3Y_15133	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
O3Y_15143	COG1280	lysine exporter protein (LysE YggA)
O3Y_15343	COG3549	Plasmid maintenance system killer
O3Y_15348	COG3093	addiction module antidote protein HigA
O3Y_15363	COG0384	phenazine biosynthesis protein PhzF
O3Y_15393	COG0346	lactoylglutathione lyase activity
O3Y_15418	COG3040	lipid binding
O3Y_15473	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O3Y_15573	COG1619	proteins homologs of microcin C7 resistance protein MccF
O3Y_15593	COG3040	lipid binding
O3Y_15648	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
O3Y_15653	COG4977	sequence-specific DNA binding
O3Y_15733	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
O3Y_15738	COG2944	sequence-specific DNA binding
O3Y_15753	COG3039	Transposase
O3Y_15758	COG0110	maltose O-acetyltransferase activity
O3Y_15773	COG0346	lactoylglutathione lyase activity
O3Y_15858	COG1943	Transposase
O3Y_15918	COG0346	lactoylglutathione lyase activity
O3Y_15938	COG1328	CTP reductase activity
O3Y_15943	COG0602	queuosine metabolic process
O3Y_15953	COG0189	ligase activity
O3Y_15953	COG4067	protein conserved in archaea
O3Y_15958	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O3Y_15958	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O3Y_15958	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
O3Y_15963	COG1105	Belongs to the carbohydrate kinase PfkB family
O3Y_15968	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
O3Y_15968	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O3Y_15973	COG1609	Transcriptional regulator
O3Y_15978	COG0420	3'-5' exonuclease activity
O3Y_15983	COG0419	ATPase involved in DNA repair
O3Y_15988	COG0784	Response regulator, receiver
O3Y_15988	COG2205	protein histidine kinase activity
O3Y_15993	COG0156	8-amino-7-oxononanoate synthase activity
O3Y_16003	COG0038	chloride channel
O3Y_16008	COG0523	cobalamin synthesis protein
O3Y_16018	COG3158	transport of potassium into the cell
O3Y_16023	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O3Y_16023	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
O3Y_16023	COG1013	pyruvate-flavodoxin oxidoreductase activity
O3Y_16023	COG0674	pyruvate-flavodoxin oxidoreductase activity
O3Y_16028	COG2205	protein histidine kinase activity
O3Y_16033	COG0745	RESPONSE REGULATOR receiver
O3Y_16038	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O3Y_16043	COG0586	Pfam SNARE associated Golgi protein
O3Y_16058	COG2200	EAL domain
O3Y_16068	COG3038	cytochrome b561
O3Y_16078	COG2116	formate transmembrane transporter activity
O3Y_16088	COG0583	DNA-binding transcription factor activity
O3Y_16098	COG3593	DNA synthesis involved in DNA repair
O3Y_16103	COG0737	Belongs to the 5'-nucleotidase family
O3Y_16118	COG2824	Alkylphosphonate utilization operon protein PhnA
O3Y_16163	COG3706	GGDEF domain
O3Y_16178	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
O3Y_16183	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
O3Y_16193	COG0745	RESPONSE REGULATOR receiver
O3Y_16213	COG0023	Translation Initiation Factor
O3Y_16223	COG1181	Belongs to the D-alanine--D-alanine ligase family
O3Y_16233	COG0045	succinate-CoA ligase (ADP-forming) activity
O3Y_16233	COG1042	CoA-binding domain protein
O3Y_16233	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O3Y_16238	COG0583	DNA-binding transcription factor activity
O3Y_16243	COG4771	TonB-dependent receptor
O3Y_16243	COG1629	transport
O3Y_16258	COG2050	protein possibly involved in aromatic compounds catabolism
O3Y_16278	COG0625	glutathione transferase activity
O3Y_16293	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
O3Y_16298	COG4172	Belongs to the ABC transporter superfamily
O3Y_16303	COG4239	(ABC) transporter, permease
O3Y_16308	COG4174	ABC transporter (Permease)
O3Y_16313	COG4166	transmembrane transport
O3Y_16358	COG3842	ATPase activity
O3Y_16368	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
O3Y_16378	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O3Y_16383	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O3Y_16388	COG1011	Hydrolase
O3Y_16398	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
O3Y_16403	COG1970	mechanosensitive ion channel activity
O3Y_16408	COG2759	Belongs to the formate--tetrahydrofolate ligase family
O3Y_16413	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O3Y_16413	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O3Y_16418	COG0302	gtp cyclohydrolase
O3Y_16428	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
O3Y_16438	COG2897	thiosulfate sulfurtransferase activity
O3Y_16443	COG2390	Transcriptional regulator
O3Y_16453	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
O3Y_16458	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
O3Y_16483	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O3Y_16508	COG0583	DNA-binding transcription factor activity
O3Y_16513	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
O3Y_16518	COG0778	Nitroreductase
O3Y_16543	COG0640	Transcriptional regulator
O3Y_16553	COG0446	pyridine nucleotide-disulphide oxidoreductase
O3Y_16613	COG1621	beta-fructofuranosidase activity
O3Y_16618	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O3Y_16623	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
O3Y_16633	COG2885	chlorophyll binding
O3Y_16638	COG0545	Peptidyl-prolyl cis-trans isomerase
O3Y_16643	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O3Y_16648	COG0840	transmembrane signaling receptor activity
O3Y_16653	COG3069	C4-dicarboxylate transmembrane transporter activity
O3Y_16658	COG1760	l-serine dehydratase
O3Y_16678	COG1609	Transcriptional regulator
O3Y_16683	COG2197	response regulator
O3Y_16688	COG3850	Histidine kinase
O3Y_16693	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
O3Y_16703	COG0243	molybdopterin cofactor binding
O3Y_16723	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
O3Y_16728	COG2197	response regulator
O3Y_16733	COG3851	Histidine kinase
O3Y_16738	COG2271	Major facilitator Superfamily
O3Y_16743	COG1840	ABC-type Fe3 transport system, periplasmic component
O3Y_16753	COG3842	ATPase activity
O3Y_16758	COG3243	poly(R)-hydroxyalkanoic acid synthase
O3Y_16768	COG0183	Belongs to the thiolase family
O3Y_16778	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O3Y_16783	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O3Y_16798	COG3706	GGDEF domain
O3Y_16803	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
O3Y_16813	COG1979	alcohol dehydrogenase
O3Y_16828	COG4191	Histidine kinase
O3Y_16833	COG1840	ABC-type Fe3 transport system, periplasmic component
O3Y_16838	COG2271	Major facilitator Superfamily
O3Y_16843	COG0469	pyruvate kinase activity
O3Y_16848	COG2205	protein histidine kinase activity
O3Y_16848	COG2198	Histidine kinase
O3Y_16848	COG0784	Response regulator, receiver
O3Y_16853	COG1879	ABC-type sugar transport system periplasmic component
O3Y_16858	COG1803	Methylglyoxal synthase
O3Y_16863	COG1335	isochorismatase
O3Y_16868	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
O3Y_16883	COG0210	DNA helicase
O3Y_16888	COG1289	transmembrane transporter activity
O3Y_16918	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
O3Y_16923	COG4149	molybdate abc transporter
O3Y_16928	COG0725	ABC transporter, periplasmic molybdate-binding protein
O3Y_16933	COG1492	cobalamin metabolic process
O3Y_16973	COG0784	Response regulator, receiver
O3Y_16973	COG5002	protein histidine kinase activity
O3Y_16978	COG1879	ABC-type sugar transport system periplasmic component
O3Y_16988	COG2827	Endonuclease containing a URI domain
O3Y_17018	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
O3Y_17023	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
O3Y_17028	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
O3Y_17033	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
O3Y_17038	COG0247	lactate metabolic process
O3Y_17043	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O3Y_17048	COG3118	belongs to the thioredoxin family
O3Y_17068	COG0583	DNA-binding transcription factor activity
O3Y_17073	COG4160	amino acid transport
O3Y_17078	COG4215	(ABC) transporter
O3Y_17083	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O3Y_17088	COG1126	abc transporter atp-binding protein
O3Y_17093	COG2425	protein containing a von Willebrand factor type A (vWA) domain
O3Y_17103	COG0494	nUDIX hydrolase
O3Y_17108	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
O3Y_17118	COG1309	transcriptional regulator
O3Y_17123	COG0513	Belongs to the DEAD box helicase family
O3Y_17128	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
O3Y_17138	COG0814	amino acid
O3Y_17143	COG0840	transmembrane signaling receptor activity
O3Y_17148	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
O3Y_17153	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
O3Y_17163	COG1984	allophanate hydrolase subunit 2
O3Y_17178	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
O3Y_17183	COG4181	ATPase activity
O3Y_17193	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
O3Y_17198	COG5001	Diguanylate cyclase
O3Y_17198	COG1716	ATPase activity
O3Y_17213	COG0484	heat shock protein binding
O3Y_17258	COG0546	phosphoglycolate phosphatase activity
O3Y_17273	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O3Y_17278	COG1368	sulfuric ester hydrolase activity
O3Y_17288	COG0513	Belongs to the DEAD box helicase family
O3Y_17293	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
O3Y_17303	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
O3Y_17313	COG3046	protein related to deoxyribodipyrimidine photolyase
O3Y_17318	COG3397	chitin binding
O3Y_17323	COG3227	Zinc metalloprotease (Elastase)
O3Y_17333	COG0010	Belongs to the arginase family
O3Y_17338	COG1166	arginine decarboxylase activity
O3Y_17348	COG2239	Acts as a magnesium transporter
O3Y_17353	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
O3Y_17358	COG0459	protein refolding
O3Y_17368	COG0527	aspartate kinase activity
O3Y_17373	COG0662	Cupin 2, conserved barrel domain protein
O3Y_17378	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
O3Y_17383	COG0456	acetyltransferase
O3Y_17388	COG2154	pterin-4-alpha-carbinolamine dehydratase
O3Y_17393	COG3186	Phenylalanine-4-hydroxylase
O3Y_17398	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O3Y_17408	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
O3Y_17413	COG0583	DNA-binding transcription factor activity
O3Y_17428	COG2171	N-acyltransferase activity
O3Y_17433	COG1253	flavin adenine dinucleotide binding
O3Y_17438	COG1765	OsmC-like protein
O3Y_17463	COG0531	amino acid
O3Y_17468	COG3706	GGDEF domain
O3Y_17478	COG3279	Response regulator of the LytR AlgR family
O3Y_17483	COG3275	phosphorelay sensor kinase activity
O3Y_17498	COG0577	efflux transmembrane transporter activity
O3Y_17498	COG1136	(ABC) transporter
O3Y_17503	COG1136	(ABC) transporter
O3Y_17518	COG4989	oxidoreductase activity
O3Y_17523	COG0366	Alpha amylase catalytic
O3Y_17538	COG2067	long-chain fatty acid transport protein
O3Y_17543	COG2267	carboxylic ester hydrolase activity
O3Y_17553	COG3227	Zinc metalloprotease (Elastase)
O3Y_17558	COG3047	cAMP biosynthetic process
O3Y_17563	COG1686	Belongs to the peptidase S11 family
O3Y_17568	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O3Y_17573	COG1271	oxidase subunit
O3Y_17578	COG1294	oxidase, subunit
O3Y_17593	COG3048	D-serine ammonia-lyase activity
O3Y_17598	COG0583	DNA-binding transcription factor activity
O3Y_17638	COG1063	alcohol dehydrogenase
O3Y_17668	COG0346	lactoylglutathione lyase activity
O3Y_17688	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
O3Y_17693	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
O3Y_17698	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
O3Y_17703	COG0363	glucosamine-6-phosphate deaminase activity
O3Y_17708	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
O3Y_17733	COG1929	Belongs to the glycerate kinase type-1 family
O3Y_17738	COG2610	gluconate transmembrane transporter activity
O3Y_17743	COG3835	regulator
O3Y_17753	COG0748	coenzyme F420 binding
O3Y_17758	COG3721	Heme iron utilization protein
O3Y_17768	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
O3Y_17773	COG0811	peptide transport
O3Y_17778	COG0848	biopolymer transport protein
O3Y_17783	COG4558	Periplasmic binding protein
O3Y_17788	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O3Y_17793	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
O3Y_17828	COG3217	Mosc domain protein beta barrel domain protein
O3Y_17828	COG0633	Ferredoxin
O3Y_17828	COG3217	Mosc domain protein beta barrel domain protein
O3Y_17828	COG0633	Ferredoxin
O3Y_17833	COG0418	dihydroorotase activity
O3Y_17843	COG3152	Membrane
O3Y_17853	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O3Y_17858	COG2354	Protein conserved in bacteria
O3Y_17863	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
O3Y_17868	COG1278	Cold shock
O3Y_17893	COG3706	GGDEF domain
O3Y_17898	COG1349	DNA-binding transcription factor activity
O3Y_17913	COG3833	ABC-type maltose transport systems, permease component
O3Y_17918	COG1175	transmembrane transport
O3Y_17928	COG3842	ATPase activity
O3Y_17933	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O3Y_17948	COG0393	Putative heavy-metal-binding
O3Y_17953	COG2197	response regulator
O3Y_17958	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O3Y_17963	COG0835	chemotaxis
O3Y_17963	COG0784	Response regulator, receiver
O3Y_17968	COG1846	Transcriptional regulator
O3Y_17973	COG3706	GGDEF domain
O3Y_18008	COG0583	DNA-binding transcription factor activity
O3Y_18013	COG5001	Diguanylate cyclase
O3Y_18023	COG1741	Belongs to the pirin family
O3Y_18028	COG3123	guanosine phosphorylase activity
O3Y_18038	COG2211	Major facilitator Superfamily
O3Y_18048	COG0840	transmembrane signaling receptor activity
O3Y_18053	COG1067	ATP-dependent peptidase activity
O3Y_18063	COG4172	Belongs to the ABC transporter superfamily
O3Y_18088	COG0583	DNA-binding transcription factor activity
O3Y_18093	COG1620	l-lactate permease
O3Y_18098	COG1304	FMN binding
O3Y_18108	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
O3Y_18118	COG0840	transmembrane signaling receptor activity
O3Y_18128	COG0513	Belongs to the DEAD box helicase family
O3Y_18133	COG0583	DNA-binding transcription factor activity
O3Y_18143	COG1902	pentaerythritol trinitrate reductase activity
O3Y_18158	COG1132	(ABC) transporter
O3Y_18168	COG1902	pentaerythritol trinitrate reductase activity
O3Y_18178	COG1280	lysine exporter protein (LysE YggA)
O3Y_18183	COG2207	Transcriptional regulator
O3Y_18203	COG1846	Transcriptional regulator
O3Y_18208	COG1764	response to oxidative stress
O3Y_18213	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
O3Y_18218	COG0697	spore germination
O3Y_18228	COG0700	Nucleoside recognition
O3Y_18233	COG3366	ferrous iron transmembrane transporter activity
O3Y_18238	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
O3Y_18248	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
O3Y_18253	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
O3Y_18258	COG2259	Doxx family
O3Y_18283	COG0363	glucosamine-6-phosphate deaminase activity
O3Y_18298	COG4580	involved in the transport of maltose and maltodextrins
O3Y_18313	COG0840	transmembrane signaling receptor activity
O3Y_18328	COG0840	transmembrane signaling receptor activity
O3Y_18338	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
O3Y_18343	COG1126	abc transporter atp-binding protein
O3Y_18353	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O3Y_18358	COG4597	amino acid ABC transporter
O3Y_18363	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O3Y_18373	COG0739	heme binding
O3Y_18378	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
O3Y_18378	COG2213	PTS system mannitol-specific
O3Y_18383	COG0246	Mannitol dehydrogenase
O3Y_18388	COG3722	fumarate hydratase activity
O3Y_18393	COG0673	inositol 2-dehydrogenase activity
O3Y_18423	COG2910	NAD(P)H-binding
O3Y_18433	COG0840	transmembrane signaling receptor activity
O3Y_18438	COG4221	oxidoreductase activity
O3Y_18448	COG1901	pseudouridine methyltransferase
O3Y_18453	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O3Y_18458	COG0531	amino acid
O3Y_18463	COG1982	Orn Lys Arg decarboxylase major
O3Y_18493	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O3Y_18518	COG1262	PFAM Formylglycine-generating sulfatase enzyme
O3Y_18528	COG0259	pyridoxamine-phosphate oxidase activity
O3Y_18558	COG0745	RESPONSE REGULATOR receiver
O3Y_18578	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
O3Y_18583	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
O3Y_18588	COG0840	transmembrane signaling receptor activity
O3Y_18593	COG0835	chemotaxis
O3Y_18598	COG0835	chemotaxis
O3Y_18603	COG0643	Histidine kinase
O3Y_18603	COG2198	Histidine kinase
O3Y_18623	COG0601	transmembrane transport
O3Y_18628	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O3Y_18638	COG2194	sulfuric ester hydrolase activity
O3Y_18643	COG0642	Histidine kinase
O3Y_18648	COG0745	RESPONSE REGULATOR receiver
O3Y_18678	COG1444	tRNA N-acetyltransferase activity
O3Y_18683	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine