locus-tag	class	description
HPY16_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPY16_00010	COG0592	DNA-directed DNA polymerase activity
HPY16_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPY16_00020	COG0187	DNA topoisomerase II activity
HPY16_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
HPY16_00035	COG3977	Valine--pyruvate aminotransferase
HPY16_00040	COG0751	glycine-tRNA ligase activity
HPY16_00045	COG0752	glycyl-tRNA synthetase alpha subunit
HPY16_00050	COG2119	membrane
HPY16_00060	COG0425	Belongs to the sulfur carrier protein TusA family
HPY16_00070	COG0604	alcohol dehydrogenase
HPY16_00080	COG0129	dihydroxy-acid dehydratase activity
HPY16_00085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY16_00100	COG0606	chelatase, subunit chli
HPY16_00105	COG0204	Acyl-transferase
HPY16_00110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY16_00115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPY16_00125	COG3084	Protein conserved in bacteria
HPY16_00130	COG4326	sporulation control protein
HPY16_00135	COG1272	protein, Hemolysin III
HPY16_00145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY16_00150	COG0569	domain protein
HPY16_00155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPY16_00155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY16_00160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPY16_00165	COG0242	peptide deformylase activity
HPY16_00170	COG1652	LysM domain
HPY16_00175	COG0758	DNA mediated transformation
HPY16_00180	COG2922	Belongs to the Smg family
HPY16_00185	COG0551	DNA topoisomerase type I activity
HPY16_00190	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPY16_00195	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPY16_00200	COG0009	L-threonylcarbamoyladenylate synthase
HPY16_00205	COG0408	coproporphyrinogen oxidase activity
HPY16_00210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPY16_00220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPY16_00260	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPY16_00265	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HPY16_00275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY16_00280	COG2104	thiamine diphosphate biosynthetic process
HPY16_00285	COG2022	thiamine diphosphate biosynthetic process
HPY16_00290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY16_00295	COG0006	proline dipeptidase activity
HPY16_00295	COG0006	proline dipeptidase activity
HPY16_00315	COG1522	sequence-specific DNA binding
HPY16_00320	COG5001	Diguanylate cyclase
HPY16_00320	COG5002	protein histidine kinase activity
HPY16_00340	COG0589	response to stress
HPY16_00345	COG1528	Iron-storage protein
HPY16_00355	COG2081	HI0933 family
HPY16_00365	COG1322	Protein conserved in bacteria
HPY16_00370	COG2226	methyltransferase
HPY16_00385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY16_00390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY16_00395	COG0805	protein transport
HPY16_00400	COG1858	cytochrome C peroxidase
HPY16_00405	COG0534	Mate efflux family protein
HPY16_00420	COG2937	Belongs to the GPAT DAPAT family
HPY16_00425	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HPY16_00430	COG3161	chorismate lyase activity
HPY16_00435	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY16_00450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY16_00455	COG0084	hydrolase, TatD family'
HPY16_00470	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY16_00470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY16_00490	COG3078	GTPase activator activity
HPY16_00510	COG2959	enzyme of heme biosynthesis
HPY16_00515	COG1587	Uroporphyrinogen-III synthase
HPY16_00520	COG0181	hydroxymethylbilane synthase activity
HPY16_00530	COG1965	Belongs to the frataxin family
HPY16_00540	COG0019	diaminopimelate decarboxylase activity
HPY16_00545	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPY16_00555	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HPY16_00560	COG1011	Hydrolase
HPY16_00565	COG2199	diguanylate cyclase activity
HPY16_00565	COG2200	EAL domain
HPY16_00565	COG3287	FIST C domain
HPY16_00580	COG0561	phosphatase activity
HPY16_00585	COG2267	carboxylic ester hydrolase activity
HPY16_00590	COG1280	lysine exporter protein (LysE YggA)
HPY16_00595	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY16_00600	COG0783	Belongs to the Dps family
HPY16_00630	COG0742	ribosomal rna small subunit methyltransferase
HPY16_00635	COG0552	protein localization to endoplasmic reticulum
HPY16_00640	COG2884	Cell division ATP-binding protein ftsE
HPY16_00645	COG2177	Part of the ABC transporter FtsEX involved in
HPY16_00650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY16_00655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY16_00670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY16_00675	COG4206	TonB-dependent receptor
HPY16_00680	COG1404	Belongs to the peptidase S8 family
HPY16_00685	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPY16_00750	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HPY16_00755	COG5001	Diguanylate cyclase
HPY16_00755	COG3300	MHYT domain
HPY16_00765	COG3852	Histidine kinase
HPY16_00775	COG0174	glutamine synthetase
HPY16_00795	COG1295	ribonuclease BN
HPY16_00800	COG1490	D-aminoacyl-tRNA deacylase activity
HPY16_00805	COG0456	acetyltransferase
HPY16_00815	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HPY16_00820	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HPY16_00825	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPY16_00830	COG3031	protein transport across the cell outer membrane
HPY16_00840	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY16_00845	COG1459	type II secretion system
HPY16_00850	COG2165	general secretion pathway protein
HPY16_00855	COG2165	general secretion pathway protein
HPY16_00860	COG2165	general secretion pathway protein
HPY16_00865	COG4795	General secretion pathway protein
HPY16_00870	COG3156	type II secretion system protein K
HPY16_00875	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY16_00880	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY16_00890	COG1218	3'(2'),5'-bisphosphate nucleotidase
HPY16_00895	COG0494	nUDIX hydrolase
HPY16_00905	COG1040	competence protein
HPY16_00915	COG0596	Alpha beta hydrolase
HPY16_00925	COG2183	response to ionizing radiation
HPY16_00930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY16_00935	COG0745	RESPONSE REGULATOR receiver
HPY16_00945	COG2233	PERMEase
HPY16_00950	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPY16_00955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY16_00960	COG1758	RNA polymerase activity
HPY16_00965	COG0194	GDP metabolic process
HPY16_00970	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HPY16_00975	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY16_00995	COG4232	protein-disulfide reductase activity
HPY16_01010	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY16_01015	COG1027	Aspartate ammonia-lyase
HPY16_01020	COG3706	GGDEF domain
HPY16_01025	COG3030	protein affecting phage T7 exclusion by the F plasmid
HPY16_01030	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPY16_01040	COG2205	protein histidine kinase activity
HPY16_01045	COG0745	RESPONSE REGULATOR receiver
HPY16_01055	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPY16_01060	COG0205	6-phosphofructokinase activity
HPY16_01065	COG1494	fructose-1,6-bisphosphatase
HPY16_01070	COG3074	FtsZ-dependent cytokinesis
HPY16_01075	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPY16_01080	COG0460	homoserine dehydrogenase
HPY16_01080	COG0527	aspartate kinase activity
HPY16_01085	COG0626	cystathionine gamma-synthase activity
HPY16_01090	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HPY16_01095	COG0281	malic enzyme
HPY16_01100	COG0254	rRNA binding
HPY16_01105	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPY16_01110	COG1609	Transcriptional regulator
HPY16_01115	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY16_01120	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPY16_01125	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPY16_01130	COG1575	Belongs to the MenA family. Type 1 subfamily
HPY16_01135	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY16_01140	COG0534	Mate efflux family protein
HPY16_01145	COG0149	triose-phosphate isomerase activity
HPY16_01170	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPY16_01175	COG0459	protein refolding
HPY16_01185	COG1509	lysine 2,3-aminomutase activity
HPY16_01190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY16_01200	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HPY16_01205	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPY16_01210	COG1053	succinate dehydrogenase
HPY16_01215	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HPY16_01220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY16_01225	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HPY16_01230	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPY16_01235	COG1045	serine acetyltransferase
HPY16_01245	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HPY16_01250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPY16_01255	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPY16_01260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY16_01265	COG0137	argininosuccinate synthase activity
HPY16_01270	COG0165	Argininosuccinate lyase
HPY16_01280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY16_01285	COG0678	peroxiredoxin activity
HPY16_01285	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY16_01295	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPY16_01325	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPY16_01330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPY16_01340	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HPY16_01345	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPY16_01350	COG0546	phosphoglycolate phosphatase activity
HPY16_01355	COG0180	Tryptophanyl-tRNA synthetase
HPY16_01370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY16_01380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPY16_01390	COG1012	belongs to the aldehyde dehydrogenase family
HPY16_01405	COG3954	Phosphoribulokinase
HPY16_01415	COG0429	hydrolase of the alpha beta-hydrolase fold
HPY16_01425	COG0488	(ABC) transporter
HPY16_01430	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPY16_01445	COG1047	Peptidyl-prolyl cis-trans
HPY16_01455	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY16_01460	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPY16_01470	COG0557	exoribonuclease II activity
HPY16_01475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY16_01480	COG0051	transcription antitermination factor activity, RNA binding
HPY16_01485	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPY16_01490	COG0088	Forms part of the polypeptide exit tunnel
HPY16_01495	COG0089	rRNA binding
HPY16_01500	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPY16_01505	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HPY16_01510	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPY16_01515	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HPY16_01520	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HPY16_01525	COG0255	Belongs to the universal ribosomal protein uL29 family
HPY16_01530	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPY16_01535	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPY16_01540	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HPY16_01545	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPY16_01550	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPY16_01555	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HPY16_01560	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HPY16_01565	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPY16_01570	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HPY16_01575	COG1841	ribosomal large subunit assembly
HPY16_01585	COG0201	protein transport
HPY16_01590	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY16_01595	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPY16_01600	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HPY16_01605	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPY16_01610	COG0202	RNA polymerase activity
HPY16_01615	COG0203	ribosomal protein L17
HPY16_01625	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY16_01630	COG3061	Opacity-associated protein A
HPY16_01630	COG3266	domain, Protein
HPY16_01635	COG0697	spore germination
HPY16_01640	COG2153	protein acetylation
HPY16_01645	COG0513	Belongs to the DEAD box helicase family
HPY16_01655	COG0737	Belongs to the 5'-nucleotidase family
HPY16_01660	COG1648	precorrin-2 dehydrogenase activity
HPY16_01660	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPY16_01665	COG0175	sulfate reduction
HPY16_01670	COG2895	sulfate adenylyltransferase (ATP) activity
HPY16_01675	COG0529	Catalyzes the synthesis of activated sulfate
HPY16_01695	COG1136	(ABC) transporter
HPY16_01710	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HPY16_01715	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY16_01720	COG0729	surface antigen
HPY16_01730	COG2105	PFAM AIG2 family protein
HPY16_01735	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPY16_01745	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY16_01750	COG0163	prenyltransferase activity
HPY16_01760	COG1178	ABC-type Fe3 transport system permease component
HPY16_01765	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HPY16_01770	COG3028	Belongs to the UPF0307 family
HPY16_01775	COG0312	modulator of DNA gyrase
HPY16_01780	COG2239	Acts as a magnesium transporter
HPY16_01785	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY16_01790	COG1660	Displays ATPase and GTPase activities
HPY16_01795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY16_01800	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY16_01810	COG1137	ATPase activity
HPY16_01815	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HPY16_01830	COG0517	IMP dehydrogenase activity
HPY16_01830	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPY16_01840	COG1127	ABC transporter
HPY16_01845	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPY16_01850	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY16_01855	COG2854	intermembrane phospholipid transfer
HPY16_01865	COG5007	Belongs to the BolA IbaG family
HPY16_01870	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPY16_01880	COG0251	oxidation-reduction process
HPY16_01890	COG0540	Belongs to the ATCase OTCase family
HPY16_01900	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HPY16_01910	COG0564	pseudouridine synthase activity
HPY16_01915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY16_01920	COG0525	valine-tRNA ligase activity
HPY16_01925	COG2927	DNA polymerase III (CHI subunit)
HPY16_01930	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY16_01935	COG0795	lipopolysaccharide-transporting ATPase activity
HPY16_01940	COG0795	lipopolysaccharide-transporting ATPase activity
HPY16_01955	COG3437	response regulator, receiver
HPY16_01995	COG0066	3-isopropylmalate dehydratase activity
HPY16_02000	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HPY16_02005	COG0473	3-isopropylmalate dehydrogenase activity
HPY16_02025	COG0583	DNA-binding transcription factor activity
HPY16_02030	COG1022	Amp-dependent synthetase and ligase
HPY16_02035	COG0028	Belongs to the TPP enzyme family
HPY16_02040	COG0440	acetolactate synthase activity
HPY16_02045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY16_02050	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HPY16_02055	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPY16_02065	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HPY16_02070	COG3079	Belongs to the UPF0149 family
HPY16_02075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY16_02080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY16_02090	COG0354	folic acid binding
HPY16_02095	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HPY16_02105	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPY16_02110	COG1595	DNA-templated transcription, initiation
HPY16_02125	COG3086	response to oxidative stress
HPY16_02130	COG0481	GTPase activity
HPY16_02140	COG0571	ribonuclease III activity
HPY16_02145	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPY16_02150	COG1381	Involved in DNA repair and RecF pathway recombination
HPY16_02155	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HPY16_02185	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY16_02190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY16_02195	COG3956	TIGRFAM MazG family protein
HPY16_02200	COG0504	CTP synthase activity
HPY16_02205	COG0148	phosphopyruvate hydratase activity
HPY16_02225	COG4991	sh3 domain protein
HPY16_02230	COG0306	phosphate transporter
HPY16_02235	COG1392	Phosphate transport regulator
HPY16_02240	COG3025	triphosphatase activity
HPY16_02250	COG0840	transmembrane signaling receptor activity
HPY16_02255	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HPY16_02260	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPY16_02260	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HPY16_02265	COG1538	Outer membrane efflux protein
HPY16_02270	COG0494	nUDIX hydrolase
HPY16_02275	COG3151	Protein conserved in bacteria
HPY16_02285	COG3150	esterase
HPY16_02290	COG0187	DNA topoisomerase II activity
HPY16_02295	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPY16_02305	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HPY16_02310	COG0237	dephospho-CoA kinase activity
HPY16_02320	COG1459	type II secretion system
HPY16_02325	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY16_02330	COG4969	Belongs to the N-Me-Phe pilin family
HPY16_02335	COG0157	Belongs to the NadC ModD family
HPY16_02350	COG0716	FMN binding
HPY16_02355	COG4974	Belongs to the 'phage' integrase family
HPY16_02360	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY16_02365	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPY16_02370	COG2186	Transcriptional regulator
HPY16_02375	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPY16_02380	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY16_02385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY16_02400	COG3116	cell division
HPY16_02405	COG0768	penicillin binding
HPY16_02410	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPY16_02415	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPY16_02425	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPY16_02430	COG0772	Belongs to the SEDS family
HPY16_02435	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPY16_02440	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY16_02450	COG0849	cell division
HPY16_02455	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPY16_02460	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HPY16_02470	COG0653	protein targeting
HPY16_02475	COG0494	nUDIX hydrolase
HPY16_02480	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HPY16_02490	COG0505	Belongs to the CarA family
HPY16_02495	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPY16_02510	COG0730	response to heat
HPY16_02515	COG0583	DNA-binding transcription factor activity
HPY16_02520	COG2860	membrane
HPY16_02525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPY16_02535	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPY16_02545	COG0493	'glutamate synthase
HPY16_02550	COG0069	glutamate synthase activity
HPY16_02550	COG0067	glutamate synthase
HPY16_02550	COG0070	glutamate synthase
HPY16_02560	COG0069	glutamate synthase activity
HPY16_02560	COG0067	glutamate synthase
HPY16_02560	COG0070	glutamate synthase
HPY16_02565	COG1242	4 iron, 4 sulfur cluster binding
HPY16_02570	COG5001	Diguanylate cyclase
HPY16_02570	COG4251	negative regulation of phosphorylation
HPY16_02570	COG3706	GGDEF domain
HPY16_02570	COG2203	Gaf domain
HPY16_02575	COG5002	protein histidine kinase activity
HPY16_02575	COG2198	Histidine kinase
HPY16_02575	COG0784	Response regulator, receiver
HPY16_02580	COG0745	RESPONSE REGULATOR receiver
HPY16_02590	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY16_02610	COG0083	homoserine kinase activity
HPY16_02615	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPY16_02620	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HPY16_02625	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HPY16_02630	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPY16_02645	COG1115	amino acid carrier protein
HPY16_02650	COG3022	response to hydroperoxide
HPY16_02660	COG0084	hydrolase, TatD family'
HPY16_02665	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY16_02675	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HPY16_02680	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HPY16_02685	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HPY16_02690	COG0813	purine-nucleoside phosphorylase activity
HPY16_02700	COG0560	Phosphoserine phosphatase
HPY16_02710	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPY16_02715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY16_02720	COG1022	Amp-dependent synthetase and ligase
HPY16_02735	COG3250	beta-galactosidase activity
HPY16_02740	COG1609	Transcriptional regulator
HPY16_02745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY16_02760	COG0189	ligase activity
HPY16_02760	COG0569	domain protein
HPY16_02765	COG0456	acetyltransferase
HPY16_02775	COG2171	N-acyltransferase activity
HPY16_02780	COG3141	response to X-ray
HPY16_02795	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HPY16_02800	COG1074	ATP-dependent DNA helicase activity
HPY16_02805	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HPY16_02815	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY16_02815	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPY16_02825	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HPY16_02830	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPY16_02835	COG2166	iron-sulfur cluster assembly
HPY16_02840	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY16_02845	COG0693	protein deglycase activity
HPY16_02850	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPY16_02865	COG1595	DNA-templated transcription, initiation
HPY16_02875	COG2211	Major facilitator Superfamily
HPY16_02880	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPY16_02890	COG2813	Specifically methylates the guanine in position
HPY16_02895	COG0271	Belongs to the BolA IbaG family
HPY16_02900	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY16_02905	COG1805	sodium ion transport
HPY16_02910	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY16_02915	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY16_02920	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY16_02925	COG2871	sodium ion transport
HPY16_02930	COG1477	protein flavinylation
HPY16_02950	COG3706	GGDEF domain
HPY16_02955	COG0733	neurotransmitter:sodium symporter activity
HPY16_02965	COG0189	ligase activity
HPY16_02970	COG4067	protein conserved in archaea
HPY16_02970	COG0189	ligase activity
HPY16_02975	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY16_02980	COG2252	PERMEase
HPY16_02985	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HPY16_03000	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPY16_03005	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HPY16_03010	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPY16_03015	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY16_03015	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY16_03030	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HPY16_03035	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY16_03040	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HPY16_03045	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPY16_03055	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HPY16_03060	COG0024	Methionine aminopeptidase
HPY16_03065	COG0052	Belongs to the universal ribosomal protein uS2 family
HPY16_03070	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPY16_03075	COG0528	UMP kinase activity
HPY16_03080	COG0233	cytoplasmic translational termination
HPY16_03085	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPY16_03090	COG0575	Belongs to the CDS family
HPY16_03095	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HPY16_03100	COG0750	zinc metalloprotease
HPY16_03110	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HPY16_03115	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY16_03120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY16_03125	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY16_03130	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY16_03135	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPY16_03140	COG0587	DNA-directed DNA polymerase activity
HPY16_03145	COG0825	malonyl-CoA metabolic process
HPY16_03155	COG0037	tRNA processing
HPY16_03165	COG3479	Phenolic acid decarboxylase
HPY16_03170	COG0347	Belongs to the P(II) protein family
HPY16_03175	COG3021	interspecies interaction between organisms
HPY16_03180	COG1388	LysM domain
HPY16_03180	COG0741	lytic transglycosylase activity
HPY16_03185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY16_03190	COG2226	methyltransferase
HPY16_03195	COG0328	RNA-DNA hybrid ribonuclease activity
HPY16_03210	COG1960	acyl-CoA dehydrogenase activity
HPY16_03215	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY16_03220	COG0121	glutamine amidotransferase
HPY16_03225	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPY16_03230	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPY16_03235	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPY16_03240	COG3706	GGDEF domain
HPY16_03245	COG1187	pseudouridine synthase activity
HPY16_03250	COG2840	Smr protein MutS2
HPY16_03265	COG3735	TraB family
HPY16_03280	COG2608	mercury ion transmembrane transporter activity
HPY16_03280	COG2217	Heavy metal translocating P-type atpase
HPY16_03285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY16_03300	COG4774	siderophore transport
HPY16_03300	COG1629	transport
HPY16_03305	COG2375	cellular response to nickel ion
HPY16_03310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY16_03310	COG3433	isochorismatase activity
HPY16_03310	COG2226	methyltransferase
HPY16_03345	COG0835	chemotaxis
HPY16_03345	COG0784	Response regulator, receiver
HPY16_03350	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY16_03355	COG1815	bacterial-type flagellum-dependent cell motility
HPY16_03370	COG1749	Flagellar hook protein flgE
HPY16_03375	COG4787	bacterial-type flagellum-dependent cell motility
HPY16_03385	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HPY16_03390	COG1706	bacterial-type flagellum-dependent cell motility
HPY16_03395	COG3951	Flagellar rod assembly protein muramidase FlgJ
HPY16_03395	COG1705	Flagellar rod assembly protein muramidase FlgJ
HPY16_03410	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY16_03415	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY16_03500	COG0012	GTP binding
HPY16_03505	COG0193	aminoacyl-tRNA hydrolase activity
HPY16_03510	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPY16_03515	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPY16_03520	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HPY16_03525	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HPY16_03530	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPY16_03535	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY16_03545	COG2912	Transglutaminase-like superfamily
HPY16_03550	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HPY16_03555	COG0737	Belongs to the 5'-nucleotidase family
HPY16_03560	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPY16_03565	COG2233	PERMEase
HPY16_03585	COG1393	Belongs to the ArsC family
HPY16_03590	COG4783	chaperone-mediated protein folding
HPY16_03610	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPY16_03625	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HPY16_03635	COG1876	peptidase activity
HPY16_03645	COG1393	Belongs to the ArsC family
HPY16_03665	COG2837	iron assimilation
HPY16_03670	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY16_03675	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY16_03680	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY16_03685	COG1334	flagellar protein FlaG
HPY16_03690	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPY16_03700	COG1516	flagellar protein fliS
HPY16_03710	COG4191	Histidine kinase
HPY16_03720	COG1677	Flagellar hook-basal body complex protein FliE
HPY16_03730	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPY16_03735	COG1317	bacterial-type flagellum organization
HPY16_03760	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY16_03785	COG1987	bacterial-type flagellum assembly
HPY16_03790	COG1684	flagellar biosynthetic protein fliR
HPY16_03795	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPY16_03800	COG2840	Smr protein MutS2
HPY16_03805	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY16_03810	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPY16_03815	COG2860	membrane
HPY16_03820	COG3101	peptidyl-lysine hydroxylation
HPY16_03830	COG0431	NADPH-dependent FMN reductase
HPY16_03840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY16_03845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY16_03850	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY16_03855	COG0735	belongs to the Fur family
HPY16_03865	COG0583	DNA-binding transcription factor activity
HPY16_03875	COG1346	cytolysis
HPY16_03890	COG0596	Alpha beta hydrolase
HPY16_03895	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HPY16_03900	COG0033	Phosphoglucomutase
HPY16_03910	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPY16_03915	COG0372	Belongs to the citrate synthase family
HPY16_03920	COG2009	succinate dehydrogenase
HPY16_03925	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HPY16_03930	COG1053	succinate dehydrogenase
HPY16_03940	COG0567	Dehydrogenase, E1 component
HPY16_03945	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY16_03950	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY16_03960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPY16_03965	COG1121	(ABC) transporter
HPY16_03970	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HPY16_03975	COG4977	sequence-specific DNA binding
HPY16_03980	COG1918	ferrous iron import across plasma membrane
HPY16_04000	COG0018	arginyl-trna synthetase
HPY16_04010	COG1025	Belongs to the peptidase M16 family
HPY16_04015	COG2062	phosphohistidine phosphatase, SixA
HPY16_04045	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HPY16_04050	COG0643	Histidine kinase
HPY16_04050	COG2198	Histidine kinase
HPY16_04050	COG0784	Response regulator, receiver
HPY16_04055	COG2201	protein-glutamate methylesterase activity
HPY16_04060	COG1192	Involved in chromosome partitioning
HPY16_04070	COG0835	chemotaxis
HPY16_04080	COG4133	protoheme IX ABC transporter activity
HPY16_04085	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY16_04090	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY16_04100	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HPY16_04105	COG1138	Cytochrome C-type biogenesis protein
HPY16_04110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPY16_04125	COG2853	Lipoprotein
HPY16_04145	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HPY16_04150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY16_04155	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPY16_04170	COG3083	sulfuric ester hydrolase activity
HPY16_04175	COG3082	Protein of unknown function (DUF1414)
HPY16_04180	COG3081	Nucleoid-associated protein
HPY16_04190	COG1757	Na H antiporter
HPY16_04195	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY16_04200	COG2095	MarC family integral membrane protein
HPY16_04205	COG1454	alcohol dehydrogenase
HPY16_04205	COG1012	belongs to the aldehyde dehydrogenase family
HPY16_04215	COG0659	secondary active sulfate transmembrane transporter activity
HPY16_04220	COG1530	ribonuclease E activity
HPY16_04225	COG0564	pseudouridine synthase activity
HPY16_04230	COG0424	maF-like protein
HPY16_04235	COG1399	metal-binding, possibly nucleic acid-binding protein
HPY16_04240	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPY16_04245	COG0416	fatty acid biosynthetic process
HPY16_04250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY16_04260	COG1028	Short-chain dehydrogenase reductase Sdr
HPY16_04265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPY16_04270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY16_04275	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY16_04280	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPY16_04285	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPY16_04295	COG0084	hydrolase, TatD family'
HPY16_04300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY16_04300	COG1263	PTS System
HPY16_04315	COG0733	neurotransmitter:sodium symporter activity
HPY16_04330	COG4667	esterase of the alpha-beta hydrolase superfamily
HPY16_04340	COG1940	carbohydrate kinase activity
HPY16_04345	COG0784	Response regulator, receiver
HPY16_04345	COG0835	chemotaxis
HPY16_04360	COG2226	methyltransferase
HPY16_04370	COG0676	glucose-6-phosphate 1-epimerase activity
HPY16_04375	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY16_04380	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY16_04390	COG3139	Protein of unknown function (DUF1315)
HPY16_04395	COG0252	asparaginase activity
HPY16_04400	COG0616	signal peptide processing
HPY16_04405	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY16_04405	COG1902	pentaerythritol trinitrate reductase activity
HPY16_04410	COG0788	formyltetrahydrofolate deformylase activity
HPY16_04420	COG1199	ATP-dependent helicase activity
HPY16_04425	COG1214	PFAM Peptidase M22, glycoprotease
HPY16_04440	COG0596	Alpha beta hydrolase
HPY16_04445	COG0318	PFAM AMP-dependent synthetase and ligase
HPY16_04450	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HPY16_04465	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HPY16_04470	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HPY16_04475	COG0436	Aminotransferase
HPY16_04480	COG1169	isochorismate synthase
HPY16_04485	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HPY16_04490	COG0596	Alpha beta hydrolase
HPY16_04510	COG3135	benzoate transporter
HPY16_04535	COG3015	lipoprotein NlpE involved in copper resistance
HPY16_04540	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HPY16_04545	COG2894	cell division
HPY16_04550	COG0850	regulation of cytokinetic process
HPY16_04555	COG3100	YcgL domain-containing protein
HPY16_04560	COG2951	lytic endotransglycosylase activity
HPY16_04570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY16_04575	COG3005	denitrification pathway
HPY16_04580	COG0243	molybdopterin cofactor binding
HPY16_04595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY16_04610	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPY16_04655	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HPY16_04660	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPY16_04665	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY16_04670	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPY16_04680	COG4191	Histidine kinase
HPY16_04690	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPY16_04700	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPY16_04705	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPY16_04710	COG0776	regulation of translation
HPY16_04715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY16_04720	COG1555	photosystem II stabilization
HPY16_04725	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HPY16_04730	COG0539	negative regulation of cytoplasmic translation
HPY16_04735	COG0776	regulation of translation
HPY16_04740	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HPY16_04745	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HPY16_04765	COG0583	DNA-binding transcription factor activity
HPY16_04775	COG0686	Belongs to the AlaDH PNT family
HPY16_04785	COG1674	ftsk spoiiie
HPY16_04790	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPY16_04795	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY16_04800	COG2186	Transcriptional regulator
HPY16_04815	COG0537	adenosine 5'-monophosphoramidase activity
HPY16_04840	COG3150	esterase
HPY16_04845	COG1252	NADH dehydrogenase
HPY16_04870	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPY16_04880	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY16_04885	COG1136	(ABC) transporter
HPY16_04890	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY16_04900	COG2333	competence protein COMEC
HPY16_04900	COG0658	competence protein
HPY16_04905	COG1132	(ABC) transporter
HPY16_04910	COG1663	tetraacyldisaccharide 4'-kinase activity
HPY16_04915	COG2835	tetraacyldisaccharide 4'-kinase activity
HPY16_04920	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPY16_04925	COG2719	SpoVR family
HPY16_04930	COG2718	Belongs to the UPF0229 family
HPY16_04935	COG2766	serine protein kinase
HPY16_04940	COG3013	Belongs to the UPF0304 family
HPY16_04950	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPY16_04955	COG0840	transmembrane signaling receptor activity
HPY16_04965	COG1882	Formate acetyltransferase
HPY16_04990	COG4160	amino acid transport
HPY16_04995	COG0708	Exodeoxyribonuclease III
HPY16_05005	COG3923	Primosomal replication protein n
HPY16_05010	COG0730	response to heat
HPY16_05015	COG1199	ATP-dependent helicase activity
HPY16_05025	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY16_05030	COG3012	SEC-C Motif Domain Protein
HPY16_05035	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY16_05040	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY16_05045	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPY16_05050	COG0215	cysteine-tRNA ligase activity
HPY16_05055	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HPY16_05060	COG0632	four-way junction helicase activity
HPY16_05070	COG1271	oxidase subunit
HPY16_05075	COG1294	oxidase, subunit
HPY16_05080	COG4890	Cyd operon protein YbgT
HPY16_05085	COG3790	cyd operon protein YbgE
HPY16_05090	COG0824	Thioesterase
HPY16_05095	COG0811	peptide transport
HPY16_05110	COG0823	Involved in the tonB-independent uptake of proteins
HPY16_05115	COG2885	chlorophyll binding
HPY16_05125	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPY16_05135	COG0784	Response regulator, receiver
HPY16_05135	COG5002	protein histidine kinase activity
HPY16_05145	COG1482	cell wall glycoprotein biosynthetic process
HPY16_05150	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY16_05150	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY16_05150	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY16_05155	COG2207	Transcriptional regulator
HPY16_05165	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY16_05170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY16_05175	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY16_05190	COG4628	conserved protein (DUF2132)
HPY16_05200	COG0415	Belongs to the DNA photolyase family
HPY16_05235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY16_05245	COG3008	intermembrane lipid transfer
HPY16_05245	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY16_05250	COG2995	paraquat-inducible protein a
HPY16_05255	COG0668	transmembrane transport
HPY16_05275	COG1309	transcriptional regulator
HPY16_05280	COG1012	belongs to the aldehyde dehydrogenase family
HPY16_05310	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY16_05315	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPY16_05320	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HPY16_05325	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HPY16_05340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY16_05345	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY16_05350	COG0297	glycogen (starch) synthase activity
HPY16_05370	COG3070	regulator of competence-specific genes
HPY16_05375	COG1609	Transcriptional regulator
HPY16_05380	COG3381	protein complex oligomerization
HPY16_05385	COG0745	RESPONSE REGULATOR receiver
HPY16_05390	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY16_05395	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY16_05400	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HPY16_05405	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HPY16_05425	COG1032	radical SAM domain protein
HPY16_05430	COG5001	Diguanylate cyclase
HPY16_05435	COG0612	Peptidase, M16
HPY16_05450	COG0583	DNA-binding transcription factor activity
HPY16_05455	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HPY16_05465	COG2350	Protein conserved in bacteria
HPY16_05470	COG1607	acyl-coa hydrolase
HPY16_05485	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY16_05490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY16_05500	COG2116	formate transmembrane transporter activity
HPY16_05505	COG4459	periplasmic nitrate reductase
HPY16_05510	COG3005	denitrification pathway
HPY16_05515	COG0243	molybdopterin cofactor binding
HPY16_05535	COG1227	inorganic diphosphatase activity
HPY16_05555	COG4172	Belongs to the ABC transporter superfamily
HPY16_05570	COG4168	peptide transport system, permease
HPY16_05580	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HPY16_05585	COG1842	Phage shock protein A
HPY16_05600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY16_05615	COG2818	Glycosylase
HPY16_05620	COG0626	cystathionine gamma-synthase activity
HPY16_05630	COG0733	neurotransmitter:sodium symporter activity
HPY16_05635	COG0564	pseudouridine synthase activity
HPY16_05640	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPY16_05645	COG4136	ATPase activity
HPY16_05650	COG4135	transport system, permease component
HPY16_05655	COG4134	Bacterial extracellular solute-binding protein
HPY16_05665	COG3313	Fe-S protein
HPY16_05675	COG0814	amino acid
HPY16_05685	COG2239	Acts as a magnesium transporter
HPY16_05690	COG2205	protein histidine kinase activity
HPY16_05690	COG0784	Response regulator, receiver
HPY16_05705	COG4934	collagen metabolic process
HPY16_05740	COG0840	transmembrane signaling receptor activity
HPY16_05750	COG4251	negative regulation of phosphorylation
HPY16_05750	COG3706	GGDEF domain
HPY16_05750	COG2203	Gaf domain
HPY16_05750	COG5001	Diguanylate cyclase
HPY16_05755	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HPY16_05760	COG5002	protein histidine kinase activity
HPY16_05775	COG1061	Type III restriction enzyme res subunit
HPY16_05780	COG1187	pseudouridine synthase activity
HPY16_05785	COG2814	Major facilitator Superfamily
HPY16_05795	COG0702	epimerase
HPY16_05800	COG0534	Mate efflux family protein
HPY16_05805	COG4181	ATPase activity
HPY16_05820	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY16_05830	COG1748	Saccharopine dehydrogenase
HPY16_05845	COG1538	Outer membrane efflux protein
HPY16_05865	COG0583	DNA-binding transcription factor activity
HPY16_05875	COG1451	nucleotide metabolic process
HPY16_05890	COG3063	Type IV pilus biogenesis stability protein PilW
HPY16_05895	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HPY16_05915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY16_05930	COG3290	protein histidine kinase activity
HPY16_05935	COG4565	transcriptional regulatory protein
HPY16_05945	COG0784	Response regulator, receiver
HPY16_05945	COG0835	chemotaxis
HPY16_05995	COG1085	galactose-1-phosphate uridylyltransferase
HPY16_06000	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPY16_06005	COG2017	converts alpha-aldose to the beta-anomer
HPY16_06020	COG3527	Alpha-acetolactate decarboxylase
HPY16_06040	COG0753	catalase activity
HPY16_06060	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY16_06110	COG1271	oxidase subunit
HPY16_06115	COG1294	oxidase, subunit
HPY16_06120	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY16_06120	COG1136	(ABC) transporter
HPY16_06125	COG0577	efflux transmembrane transporter activity
HPY16_06125	COG1136	(ABC) transporter
HPY16_06130	COG0577	efflux transmembrane transporter activity
HPY16_06130	COG1136	(ABC) transporter
HPY16_06180	COG2816	NAD+ diphosphatase activity
HPY16_06185	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY16_06200	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY16_06210	COG2723	6-phospho-beta-galactosidase activity
HPY16_06215	COG1609	Transcriptional regulator
HPY16_06220	COG0251	oxidation-reduction process
HPY16_06225	COG2731	YhcH YjgK YiaL family protein
HPY16_06230	COG0584	glycerophosphoryl diester phosphodiesterase
HPY16_06235	COG1349	DNA-binding transcription factor activity
HPY16_06240	COG3842	ATPase activity
HPY16_06245	COG0395	ABC-type sugar transport system, permease component
HPY16_06250	COG1175	transmembrane transport
HPY16_06265	COG0811	peptide transport
HPY16_06270	COG0811	peptide transport
HPY16_06275	COG0848	biopolymer transport protein
HPY16_06280	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY16_06290	COG1793	dna ligase
HPY16_06300	COG0534	Mate efflux family protein
HPY16_06310	COG3001	Fructosamine kinase
HPY16_06320	COG0791	NLP P60 protein
HPY16_06325	COG0840	transmembrane signaling receptor activity
HPY16_06340	COG1940	carbohydrate kinase activity
HPY16_06355	COG0746	molybdenum cofactor guanylyltransferase activity
HPY16_06360	COG3842	ATPase activity
HPY16_06365	COG4662	Binding-protein-dependent transport system inner membrane component
HPY16_06375	COG2204	response regulator
HPY16_06380	COG3852	Histidine kinase
HPY16_06385	COG0488	(ABC) transporter
HPY16_06390	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPY16_06420	COG0243	molybdopterin cofactor binding
HPY16_06420	COG3383	formate dehydrogenase (NAD+) activity
HPY16_06425	COG0437	4 iron, 4 sulfur cluster binding
HPY16_06440	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPY16_06445	COG1666	GTP binding
HPY16_06450	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY16_06465	COG2996	Protein conserved in bacteria
HPY16_06475	COG3008	intermembrane lipid transfer
HPY16_06480	COG2995	paraquat-inducible protein a
HPY16_06485	COG1132	(ABC) transporter
HPY16_06490	COG1956	GAF domain-containing protein
HPY16_06495	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HPY16_06510	COG0308	aminopeptidase N
HPY16_06525	COG0167	dihydroorotate dehydrogenase activity
HPY16_06535	COG0116	Belongs to the methyltransferase superfamily
HPY16_06535	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY16_06560	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY16_06565	COG1067	ATP-dependent peptidase activity
HPY16_06570	COG3120	sequence-specific DNA binding
HPY16_06585	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HPY16_06585	COG1073	alpha beta
HPY16_06585	COG3064	Membrane
HPY16_06590	COG2994	toxin metabolic process
HPY16_06615	COG0784	Response regulator, receiver
HPY16_06615	COG2205	protein histidine kinase activity
HPY16_06630	COG3278	Belongs to the heme-copper respiratory oxidase family
HPY16_06645	COG2010	Cytochrome c
HPY16_06655	COG2217	Heavy metal translocating P-type atpase
HPY16_06670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPY16_06675	COG0589	response to stress
HPY16_06680	COG0037	tRNA processing
HPY16_06700	COG3842	ATPase activity
HPY16_06710	COG1177	transmembrane transport
HPY16_06720	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY16_06735	COG1115	amino acid carrier protein
HPY16_06740	COG1280	lysine exporter protein (LysE YggA)
HPY16_06770	COG3501	Rhs element vgr protein
HPY16_06780	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HPY16_06800	COG0513	Belongs to the DEAD box helicase family
HPY16_06805	COG2076	Multidrug Resistance protein
HPY16_06810	COG0415	Belongs to the DNA photolyase family
HPY16_06815	COG0477	Major facilitator Superfamily
HPY16_06820	COG0583	DNA-binding transcription factor activity
HPY16_06830	COG0402	S-adenosylhomocysteine deaminase activity
HPY16_06835	COG0095	Lipoate-protein ligase
HPY16_06840	COG0443	Heat shock 70 kDa protein
HPY16_06850	COG1643	Atp-dependent helicase
HPY16_06880	COG0443	Heat shock 70 kDa protein
HPY16_06885	COG0443	Heat shock 70 kDa protein
HPY16_06890	COG3706	GGDEF domain
HPY16_06920	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HPY16_06925	COG0602	queuosine metabolic process
HPY16_06930	COG0561	phosphatase activity
HPY16_06940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY16_06945	COG4597	amino acid ABC transporter
HPY16_06950	COG0765	amino acid transport
HPY16_06955	COG1126	abc transporter atp-binding protein
HPY16_06960	COG0670	Belongs to the BI1 family
HPY16_06965	COG2920	part of a sulfur-relay system
HPY16_06970	COG1254	Belongs to the acylphosphatase family
HPY16_06975	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY16_06980	COG3706	GGDEF domain
HPY16_06995	COG3437	response regulator, receiver
HPY16_07000	COG0625	glutathione transferase activity
HPY16_07010	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HPY16_07020	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY16_07050	COG0372	Belongs to the citrate synthase family
HPY16_07055	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HPY16_07080	COG0583	DNA-binding transcription factor activity
HPY16_07085	COG4771	TonB-dependent receptor
HPY16_07110	COG1129	ABC transporter
HPY16_07135	COG0745	RESPONSE REGULATOR receiver
HPY16_07140	COG5002	protein histidine kinase activity
HPY16_07145	COG3713	MltA-interacting MipA family protein
HPY16_07150	COG2990	Protein conserved in bacteria
HPY16_07160	COG4191	Histidine kinase
HPY16_07160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY16_07165	COG0471	metal ion transport
HPY16_07175	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY16_07190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY16_07200	COG3768	UPF0283 membrane protein
HPY16_07205	COG3106	COG3106 Predicted ATPase
HPY16_07225	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY16_07230	COG0494	nUDIX hydrolase
HPY16_07235	COG0814	amino acid
HPY16_07240	COG1760	l-serine dehydratase
HPY16_07245	COG0720	synthase
HPY16_07250	COG0840	transmembrane signaling receptor activity
HPY16_07255	COG0017	Asparaginyl-tRNA synthetase
HPY16_07260	COG0351	phosphomethylpyrimidine kinase
HPY16_07260	COG0352	thiamine-phosphate diphosphorylase activity
HPY16_07265	COG3437	response regulator, receiver
HPY16_07265	COG2770	Histidine kinase
HPY16_07270	COG1448	Aminotransferase
HPY16_07285	COG0840	transmembrane signaling receptor activity
HPY16_07290	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HPY16_07295	COG2943	transferase activity, transferring hexosyl groups
HPY16_07300	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY16_07305	COG1846	Transcriptional regulator
HPY16_07330	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY16_07345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY16_07350	COG3108	Peptidase M15
HPY16_07380	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPY16_07390	COG2814	Major facilitator Superfamily
HPY16_07410	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY16_07415	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY16_07420	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY16_07450	COG0840	transmembrane signaling receptor activity
HPY16_07465	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HPY16_07470	COG4139	cobalamin transport
HPY16_07475	COG2988	succinylglutamate desuccinylase activity
HPY16_07495	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HPY16_07500	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY16_07510	COG2925	Exonuclease
HPY16_07515	COG1380	Effector of murein hydrolase LrgA
HPY16_07520	COG1346	cytolysis
HPY16_07550	COG0776	regulation of translation
HPY16_07555	COG0072	phenylalanine-tRNA ligase activity
HPY16_07555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY16_07560	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPY16_07600	COG0322	excinuclease ABC activity
HPY16_07605	COG2197	response regulator
HPY16_07610	COG0417	DNA replication proofreading
HPY16_07615	COG5001	Diguanylate cyclase
HPY16_07625	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY16_07630	COG3099	Belongs to the UPF0263 family
HPY16_07645	COG1228	amidohydrolase
HPY16_07650	COG0010	Belongs to the arginase family
HPY16_07655	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPY16_07660	COG2986	histidine ammonia-lyase
HPY16_07680	COG0247	lactate metabolic process
HPY16_07680	COG0277	FAD linked oxidase domain protein
HPY16_07695	COG2885	chlorophyll binding
HPY16_07715	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPY16_07725	COG0281	malic enzyme
HPY16_07735	COG2949	membrane
HPY16_07740	COG3706	GGDEF domain
HPY16_07745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY16_07755	COG0492	ferredoxin-NADP+ reductase activity
HPY16_07760	COG4988	ABC transporter
HPY16_07765	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPY16_07770	COG1187	pseudouridine synthase activity
HPY16_07775	COG0009	L-threonylcarbamoyladenylate synthase
HPY16_07780	COG0613	PHP domain protein
HPY16_07790	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY16_07795	COG0512	Glutamine amidotransferase of anthranilate synthase
HPY16_07800	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPY16_07805	COG0135	phosphoribosylanthranilate isomerase activity
HPY16_07805	COG0134	indole-3-glycerol-phosphate synthase activity
HPY16_07810	COG0133	tryptophan synthase activity
HPY16_07815	COG0159	tryptophan synthase activity
HPY16_07825	COG1435	thymidine kinase activity
HPY16_07830	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPY16_07835	COG1801	Protein of unknown function DUF72
HPY16_07840	COG4106	trans-aconitate 2-methyltransferase activity
HPY16_07845	COG0500	methyltransferase
HPY16_07850	COG4067	protein conserved in archaea
HPY16_07850	COG0189	ligase activity
HPY16_07865	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HPY16_07875	COG3852	Histidine kinase
HPY16_07890	COG3070	regulator of competence-specific genes
HPY16_07900	COG2431	L-lysine efflux transmembrane transporter activity
HPY16_07910	COG0076	glutamate decarboxylase activity
HPY16_07915	COG1737	Transcriptional regulator
HPY16_07920	COG1454	alcohol dehydrogenase
HPY16_07920	COG1012	belongs to the aldehyde dehydrogenase family
HPY16_07925	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY16_07930	COG2985	domain, Protein
HPY16_07930	COG3273	potassium ion transport
HPY16_07935	COG0542	response to heat
HPY16_07940	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPY16_07945	COG1278	Cold shock
HPY16_07955	COG1187	pseudouridine synthase activity
HPY16_07960	COG0140	phosphoribosyl-ATP diphosphatase activity
HPY16_07960	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HPY16_07965	COG0107	imidazoleglycerol-phosphate synthase activity
HPY16_07970	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY16_07975	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPY16_07980	COG0131	Imidazoleglycerol-phosphate dehydratase
HPY16_07980	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY16_07985	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPY16_07990	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPY16_07995	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HPY16_08000	COG1757	Na H antiporter
HPY16_08005	COG2916	Histone family protein nucleoid-structuring protein H-NS
HPY16_08010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY16_08015	COG0482	sulfurtransferase activity
HPY16_08020	COG2915	High frequency lysogenization protein hflD homolog
HPY16_08025	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPY16_08035	COG2268	Band 7 protein
HPY16_08045	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPY16_08060	COG0300	oxidoreductase activity
HPY16_08070	COG0501	Belongs to the peptidase M48B family
HPY16_08080	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPY16_08085	COG2226	methyltransferase
HPY16_08090	COG0156	8-amino-7-oxononanoate synthase activity
HPY16_08095	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY16_08100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPY16_08105	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPY16_08110	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPY16_08115	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPY16_08120	COG0653	protein targeting
HPY16_08125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY16_08130	COG3706	GGDEF domain
HPY16_08140	COG4120	Belongs to the binding-protein-dependent transport system permease family
HPY16_08150	COG4628	conserved protein (DUF2132)
HPY16_08155	COG3092	negative regulation of chromosome organization
HPY16_08160	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY16_08165	COG0280	phosphate acetyltransferase
HPY16_08165	COG0857	belongs to the CobB CobQ family
HPY16_08170	COG0435	Glutathione S-transferase
HPY16_08175	COG4608	Belongs to the ABC transporter superfamily
HPY16_08180	COG0444	Belongs to the ABC transporter superfamily
HPY16_08185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY16_08190	COG0601	transmembrane transport
HPY16_08210	COG2204	response regulator
HPY16_08215	COG3300	MHYT domain
HPY16_08215	COG5001	Diguanylate cyclase
HPY16_08220	COG4191	Histidine kinase
HPY16_08225	COG5002	protein histidine kinase activity
HPY16_08235	COG2201	protein-glutamate methylesterase activity
HPY16_08250	COG0009	L-threonylcarbamoyladenylate synthase
HPY16_08265	COG1881	PFAM PEBP family protein
HPY16_08290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY16_08295	COG0640	Transcriptional regulator
HPY16_08305	COG3706	GGDEF domain
HPY16_08325	COG1946	Acyl-CoA thioesterase
HPY16_08330	COG1522	sequence-specific DNA binding
HPY16_08340	COG0616	signal peptide processing
HPY16_08345	COG1028	Short-chain dehydrogenase reductase Sdr
HPY16_08350	COG2983	Belongs to the UPF0260 family
HPY16_08360	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HPY16_08365	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HPY16_08370	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPY16_08375	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPY16_08380	COG2832	Protein of unknown function (DUF454)
HPY16_08385	COG0745	RESPONSE REGULATOR receiver
HPY16_08390	COG0583	DNA-binding transcription factor activity
HPY16_08395	COG0778	Nitroreductase
HPY16_08400	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY16_08400	COG1024	Enoyl-CoA hydratase
HPY16_08405	COG0183	Belongs to the thiolase family
HPY16_08420	COG2067	long-chain fatty acid transport protein
HPY16_08430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY16_08435	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HPY16_08440	COG2982	Protein involved in outer membrane biogenesis
HPY16_08445	COG0572	uridine kinase
HPY16_08450	COG0489	protein tyrosine kinase activity
HPY16_08455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY16_08455	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY16_08465	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY16_08475	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HPY16_08475	COG0517	IMP dehydrogenase activity
HPY16_08475	COG0617	tRNA 3'-terminal CCA addition
HPY16_08480	COG2199	diguanylate cyclase activity
HPY16_08485	COG0314	molybdopterin synthase activity
HPY16_08490	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HPY16_08495	COG0315	cyclic pyranopterin monophosphate synthase activity
HPY16_08500	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPY16_08505	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPY16_08510	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HPY16_08515	COG2198	Histidine kinase
HPY16_08520	COG2204	response regulator
HPY16_08525	COG0556	nucleotide-excision repair
HPY16_08535	COG4657	Part of a membrane complex involved in electron transport
HPY16_08540	COG2878	Part of a membrane complex involved in electron transport
HPY16_08545	COG4656	Part of a membrane complex involved in electron transport
HPY16_08560	COG4660	Part of a membrane complex involved in electron transport
HPY16_08565	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPY16_08570	COG0346	lactoylglutathione lyase activity
HPY16_08585	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPY16_08590	COG2056	Na+-H+ antiporter family
HPY16_08600	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPY16_08605	COG1286	toxin biosynthetic process
HPY16_08610	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HPY16_08615	COG0285	dihydrofolate synthase activity
HPY16_08620	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPY16_08625	COG0101	tRNA pseudouridine synthase activity
HPY16_08640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY16_08640	COG1263	PTS System
HPY16_08640	COG2190	(PTS) system
HPY16_08645	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPY16_08650	COG1940	carbohydrate kinase activity
HPY16_08650	COG1846	Transcriptional regulator
HPY16_08655	COG4651	solute:proton antiporter activity
HPY16_08655	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY16_08660	COG0367	asparagine synthase
HPY16_08670	COG3104	oligopeptide transport
HPY16_08675	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPY16_08680	COG0563	adenylate kinase activity
HPY16_08685	COG0326	Molecular chaperone. Has ATPase activity
HPY16_08690	COG3710	Transcriptional regulator
HPY16_08705	COG0622	Phosphoesterase
HPY16_08710	COG1090	epimerase
HPY16_08715	COG0300	oxidoreductase activity
HPY16_08720	COG3118	belongs to the thioredoxin family
HPY16_08725	COG0330	HflC and HflK could
HPY16_08730	COG1585	Membrane protein implicated in regulation of membrane protease activity
HPY16_08735	COG0789	Transcriptional regulator
HPY16_08750	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPY16_08755	COG3115	cell septum assembly
HPY16_08760	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HPY16_08765	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPY16_08770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY16_08780	COG2190	(PTS) system
HPY16_08785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY16_08790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY16_08795	COG1702	phosphate starvation-inducible protein PhoH
HPY16_08805	COG4535	Mg2 and Co2 transporter CorC
HPY16_08810	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPY16_08815	COG2888	peptidyl-tyrosine sulfation
HPY16_08820	COG0495	leucyl-tRNA aminoacylation
HPY16_08825	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HPY16_08830	COG1466	dna polymerase III delta subunit
HPY16_08835	COG0799	negative regulation of ribosome biogenesis
HPY16_08840	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HPY16_08845	COG0768	penicillin binding
HPY16_08850	COG0772	Belongs to the SEDS family
HPY16_08855	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY16_08860	COG1686	Belongs to the peptidase S11 family
HPY16_08865	COG2921	Belongs to the UPF0250 family
HPY16_08870	COG0321	lipoyl(octanoyl) transferase activity
HPY16_08875	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPY16_08885	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY16_08910	COG1596	polysaccharide export
HPY16_08920	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY16_08950	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HPY16_08960	COG0438	transferase activity, transferring glycosyl groups
HPY16_08970	COG1045	serine acetyltransferase
HPY16_08990	COG0110	maltose O-acetyltransferase activity
HPY16_08995	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPY16_09000	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPY16_09005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY16_09010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY16_09040	COG0366	Alpha amylase catalytic
HPY16_09045	COG1263	PTS System
HPY16_09045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY16_09050	COG1609	Transcriptional regulator
HPY16_09055	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY16_09060	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPY16_09065	COG2011	ABC-type metal ion transport system permease component
HPY16_09070	COG1464	Belongs to the NlpA lipoprotein family
HPY16_09075	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HPY16_09085	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY16_09085	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY16_09095	COG3706	GGDEF domain
HPY16_09100	COG1611	Belongs to the LOG family
HPY16_09105	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY16_09110	COG2363	Small membrane protein
HPY16_09115	COG0583	DNA-binding transcription factor activity
HPY16_09120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY16_09120	COG0301	tRNA thio-modification
HPY16_09130	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPY16_09135	COG1722	exodeoxyribonuclease VII activity
HPY16_09140	COG0142	geranyltranstransferase activity
HPY16_09145	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPY16_09150	COG0564	pseudouridine synthase activity
HPY16_09155	COG3098	single-species biofilm formation
HPY16_09170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY16_09180	COG1671	Belongs to the UPF0178 family
HPY16_09185	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY16_09190	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY16_09195	COG0254	rRNA binding
HPY16_09200	COG1720	tRNA m6t6A37 methyltransferase activity
HPY16_09205	COG0442	prolyl-tRNA aminoacylation
HPY16_09225	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPY16_09225	COG0047	phosphoribosylformylglycinamidine synthase activity
HPY16_09235	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HPY16_09245	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY16_09275	COG0484	heat shock protein binding
HPY16_09280	COG0443	Heat shock 70 kDa protein
HPY16_09285	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPY16_09290	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPY16_09295	COG0497	DNA recombination
HPY16_09300	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY16_09305	COG2914	Belongs to the UPF0125 (RnfH) family
HPY16_09310	COG2867	negative regulation of translational initiation
HPY16_09315	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPY16_09395	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HPY16_09400	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HPY16_09405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY16_09425	COG3051	citrate lyase alpha subunit
HPY16_09430	COG2301	Belongs to the HpcH HpaI aldolase family
HPY16_09440	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HPY16_09450	COG3630	sodium ion export across plasma membrane
HPY16_09455	COG5016	pyruvate
HPY16_09455	COG0511	ligase activity, forming carbon-carbon bonds
HPY16_09460	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY16_09470	COG4565	transcriptional regulatory protein
HPY16_09500	COG1115	amino acid carrier protein
HPY16_09505	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HPY16_09510	COG0583	DNA-binding transcription factor activity
HPY16_09520	COG1120	ATPase activity
HPY16_09525	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY16_09530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY16_09535	COG4592	Periplasmic binding protein
HPY16_09545	COG1028	Short-chain dehydrogenase reductase Sdr
HPY16_09550	COG1169	isochorismate synthase
HPY16_09555	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY16_09560	COG1535	isochorismatase
HPY16_09560	COG3433	isochorismatase activity
HPY16_09565	COG1584	GPR1 FUN34 yaaH family protein
HPY16_09575	COG3023	N-Acetylmuramoyl-L-alanine amidase
HPY16_09585	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPY16_09585	COG0519	Catalyzes the synthesis of GMP from XMP
HPY16_09590	COG0516	GMP reductase activity
HPY16_09590	COG0517	IMP dehydrogenase activity
HPY16_09595	COG1570	exodeoxyribonuclease VII activity
HPY16_09610	COG1160	GTP binding
HPY16_09615	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY16_09620	COG2976	Protein conserved in bacteria
HPY16_09625	COG0124	histidyl-tRNA synthetase
HPY16_09630	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HPY16_09645	COG0105	UTP biosynthetic process
HPY16_09650	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY16_09655	COG2975	iron-sulfur cluster assembly
HPY16_09660	COG0633	Ferredoxin
HPY16_09680	COG0822	iron-sulfur transferase activity
HPY16_09685	COG1104	cysteine desulfurase activity
HPY16_09690	COG1959	2 iron, 2 sulfur cluster binding
HPY16_09700	COG0483	inositol monophosphate 1-phosphatase activity
HPY16_09705	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY16_09710	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY16_09715	COG1862	Preprotein translocase
HPY16_09725	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HPY16_09730	COG0517	IMP dehydrogenase activity
HPY16_09740	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPY16_09745	COG0583	DNA-binding transcription factor activity
HPY16_09750	COG0450	alkyl hydroperoxide reductase
HPY16_09755	COG3142	Participates in the control of copper homeostasis
HPY16_09770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY16_09775	COG0581	inorganic phosphate transmembrane transporter activity
HPY16_09785	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPY16_09790	COG0248	Ppx GppA phosphatase
HPY16_09800	COG5002	protein histidine kinase activity
HPY16_09805	COG0745	RESPONSE REGULATOR receiver
HPY16_09820	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY16_09865	COG0542	response to heat
HPY16_09875	COG0564	pseudouridine synthase activity
HPY16_09880	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY16_09885	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY16_09890	COG0077	Prephenate dehydratase
HPY16_09890	COG1605	Chorismate mutase
HPY16_09895	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY16_09900	COG5001	Diguanylate cyclase
HPY16_09910	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HPY16_09920	COG0488	(ABC) transporter
HPY16_09930	COG0287	Prephenate dehydrogenase
HPY16_09930	COG1605	Chorismate mutase
HPY16_09935	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY16_09940	COG3275	phosphorelay sensor kinase activity
HPY16_09945	COG3279	Response regulator of the LytR AlgR family
HPY16_09955	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HPY16_09960	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY16_09970	COG1966	Carbon starvation protein
HPY16_09975	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPY16_09980	COG1047	Peptidyl-prolyl cis-trans
HPY16_09985	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPY16_09995	COG0196	riboflavin kinase activity
HPY16_10000	COG0728	peptidoglycan biosynthetic process
HPY16_10005	COG0268	Binds directly to 16S ribosomal RNA
HPY16_10010	COG0640	Transcriptional regulator
HPY16_10015	COG0583	DNA-binding transcription factor activity
HPY16_10020	COG1283	sodium-dependent phosphate transmembrane transporter activity
HPY16_10030	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HPY16_10035	COG0730	response to heat
HPY16_10040	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HPY16_10045	COG0494	nUDIX hydrolase
HPY16_10050	COG3066	DNA modification
HPY16_10055	COG0667	Aldo Keto reductase
HPY16_10065	COG2204	response regulator
HPY16_10070	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPY16_10090	COG0513	Belongs to the DEAD box helicase family
HPY16_10115	COG3153	acetyltransferase
HPY16_10120	COG3154	lipid carrier protein
HPY16_10130	COG0826	peptidase U32
HPY16_10135	COG0826	peptidase U32
HPY16_10155	COG1185	polyribonucleotide nucleotidyltransferase activity
HPY16_10160	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HPY16_10170	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPY16_10175	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPY16_10180	COG0195	Participates in both transcription termination and antitermination
HPY16_10185	COG0779	Required for maturation of 30S ribosomal subunits
HPY16_10200	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY16_10210	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPY16_10215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPY16_10220	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HPY16_10225	COG1534	Rna-binding protein
HPY16_10230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY16_10235	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY16_10240	COG2027	D-alanyl-D-alanine carboxypeptidase
HPY16_10245	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY16_10250	COG0739	heme binding
HPY16_10265	COG0316	Belongs to the HesB IscA family
HPY16_10275	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPY16_10280	COG0628	permease
HPY16_10285	COG2813	Specifically methylates the guanine in position
HPY16_10290	COG2205	protein histidine kinase activity
HPY16_10290	COG0784	Response regulator, receiver
HPY16_10295	COG0747	negative chemotaxis
HPY16_10305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY16_10310	COG0444	Belongs to the ABC transporter superfamily
HPY16_10315	COG4608	Belongs to the ABC transporter superfamily
HPY16_10325	COG2971	BadF BadG BcrA BcrD
HPY16_10345	COG3842	ATPase activity
HPY16_10355	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY16_10360	COG0004	ammonium transporteR
HPY16_10365	COG0347	Belongs to the P(II) protein family
HPY16_10370	COG3112	Uncharacterised protein family (UPF0231)
HPY16_10375	COG1049	propionate catabolic process, 2-methylcitrate cycle
HPY16_10380	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPY16_10385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPY16_10390	COG1643	Atp-dependent helicase
HPY16_10400	COG1489	DNA binding
HPY16_10410	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY16_10420	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY16_10425	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HPY16_10430	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HPY16_10435	COG0842	Transport permease protein
HPY16_10440	COG1131	(ABC) transporter
HPY16_10445	COG0659	secondary active sulfate transmembrane transporter activity
HPY16_10450	COG0288	reversible hydration of carbon dioxide
HPY16_10465	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPY16_10470	COG3107	peptidoglycan biosynthetic process
HPY16_10475	COG0792	nuclease activity
HPY16_10480	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY16_10485	COG2823	Periplasmic or secreted lipoprotein
HPY16_10490	COG2969	positive regulation of protein catabolic process
HPY16_10495	COG0625	glutathione transferase activity
HPY16_10500	COG2857	Cytochrome c1
HPY16_10505	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPY16_10510	COG0723	plastoquinol--plastocyanin reductase activity
HPY16_10515	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HPY16_10520	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPY16_10525	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HPY16_10535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY16_10540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY16_10545	COG0335	large ribosomal subunit rRNA binding
HPY16_10550	COG0336	Belongs to the RNA methyltransferase TrmD family
HPY16_10555	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HPY16_10560	COG0228	four-way junction DNA binding
HPY16_10565	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPY16_10570	COG4137	Cytochrome C assembly protein
HPY16_10575	COG4536	flavin adenine dinucleotide binding
HPY16_10580	COG1854	S-ribosylhomocysteine lyase activity
HPY16_10585	COG2918	glutathione biosynthetic process
HPY16_10590	COG0612	Peptidase, M16
HPY16_10595	COG1238	metal cluster binding
HPY16_10605	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY16_10610	COG5016	pyruvate
HPY16_10610	COG0511	ligase activity, forming carbon-carbon bonds
HPY16_10615	COG3630	sodium ion export across plasma membrane
HPY16_10660	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HPY16_10665	COG0527	aspartate kinase activity
HPY16_10670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPY16_10680	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPY16_10690	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HPY16_10695	COG4208	sulfate ABC transporter
HPY16_10715	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HPY16_10720	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY16_10730	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPY16_10735	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HPY16_10740	COG0585	pseudouridine synthase activity
HPY16_10745	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPY16_10750	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPY16_10755	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HPY16_10760	COG1968	undecaprenyl-diphosphatase activity
HPY16_10765	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY16_10770	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPY16_10775	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPY16_10785	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPY16_10790	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPY16_10795	COG1610	YqeY-like protein
HPY16_10800	COG0358	DNA primase activity
HPY16_10820	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY16_10825	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPY16_10830	COG1349	DNA-binding transcription factor activity
HPY16_10850	COG1279	arginine transmembrane transporter activity
HPY16_10855	COG0668	transmembrane transport
HPY16_10860	COG0191	fructose-bisphosphate aldolase activity
HPY16_10865	COG0126	phosphoglycerate kinase activity
HPY16_10870	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY16_10875	COG4771	TonB-dependent receptor
HPY16_10880	COG0583	DNA-binding transcription factor activity
HPY16_10885	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY16_10890	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HPY16_10895	COG3091	SprT-like family
HPY16_10900	COG2356	endonuclease I
HPY16_10905	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPY16_10910	COG0189	ligase activity
HPY16_10915	COG1678	Uncharacterized ACR, COG1678
HPY16_10920	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPY16_10925	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY16_10945	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPY16_10950	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPY16_10955	COG0762	integral membrane protein
HPY16_10960	COG1872	DUF167
HPY16_10970	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPY16_10975	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPY16_10980	COG2066	Belongs to the glutaminase family
HPY16_10985	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPY16_10990	COG1194	a g-specific adenine glycosylase
HPY16_10995	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HPY16_11000	COG0741	lytic transglycosylase activity
HPY16_11025	COG0840	transmembrane signaling receptor activity
HPY16_11055	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HPY16_11060	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HPY16_11065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY16_11070	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPY16_11075	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HPY16_11080	COG2967	ApaG domain
HPY16_11085	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPY16_11095	COG3610	response to peptide
HPY16_11100	COG2966	Psort location CytoplasmicMembrane, score
HPY16_11105	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPY16_11110	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HPY16_11115	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPY16_11120	COG0142	geranyltranstransferase activity
HPY16_11125	COG0531	amino acid
HPY16_11130	COG0039	L-malate dehydrogenase activity
HPY16_11135	COG1438	arginine binding
HPY16_11140	COG2358	TRAP transporter, solute receptor (TAXI family
HPY16_11150	COG0589	response to stress
HPY16_11170	COG2235	arginine
HPY16_11175	COG0312	modulator of DNA gyrase
HPY16_11180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPY16_11185	COG3164	Protein of unknown function
HPY16_11190	COG1530	ribonuclease E activity
HPY16_11195	COG0424	maF-like protein
HPY16_11200	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HPY16_11205	COG1792	Involved in formation and maintenance of cell shape
HPY16_11210	COG1077	Cell shape determining protein MreB Mrl
HPY16_11255	COG1459	type II secretion system
HPY16_11260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY16_11270	COG3267	Type II secretory pathway component ExeA
HPY16_11270	COG3409	Peptidoglycan-binding domain 1 protein
HPY16_11295	COG2200	EAL domain
HPY16_11295	COG2199	diguanylate cyclase activity
HPY16_11300	COG0629	single-stranded DNA binding
HPY16_11315	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPY16_11325	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY16_11330	COG0527	aspartate kinase activity
HPY16_11335	COG0646	methionine synthase
HPY16_11335	COG1410	methionine synthase
HPY16_11410	COG0175	sulfate reduction
HPY16_11420	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY16_11445	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY16_11450	COG0735	belongs to the Fur family
HPY16_11465	COG0166	Belongs to the GPI family
HPY16_11470	COG0432	Pfam Uncharacterised protein family UPF0047
HPY16_11475	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY16_11490	COG0359	binds to the 23S rRNA
HPY16_11495	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HPY16_11500	COG2965	DNA replication, synthesis of RNA primer
HPY16_11505	COG0360	Binds together with S18 to 16S ribosomal RNA
HPY16_11515	COG2906	2 iron, 2 sulfur cluster binding
HPY16_11520	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY16_11525	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY16_11530	COG0049	tRNA binding
HPY16_11545	COG2923	Belongs to the DsrF TusC family
HPY16_11550	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HPY16_11555	COG2964	Protein conserved in bacteria
HPY16_11565	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY16_11575	COG2900	Belongs to the SlyX family
HPY16_11580	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HPY16_11585	COG0330	HflC and HflK could
HPY16_11590	COG0330	HflC and HflK could
HPY16_11595	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPY16_11600	COG1923	regulation of RNA biosynthetic process
HPY16_11605	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPY16_11610	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPY16_11620	COG0802	atpase or kinase
HPY16_11625	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPY16_11675	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HPY16_11680	COG1162	GTPase activity
HPY16_11685	COG0688	phosphatidylethanolamine metabolic process
HPY16_11690	COG0471	metal ion transport
HPY16_11700	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HPY16_11705	COG4942	peptidase
HPY16_11720	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HPY16_11725	COG2816	NAD+ diphosphatase activity
HPY16_11730	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HPY16_11735	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPY16_11740	COG0085	RNA polymerase activity
HPY16_11745	COG0222	ribosome binding
HPY16_11750	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPY16_11760	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPY16_11765	COG0250	Participates in transcription elongation, termination and antitermination
HPY16_11770	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY16_11775	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY16_11800	COG1072	(Pantothenic acid kinase))
HPY16_11810	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPY16_11820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPY16_11865	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPY16_11880	COG3118	belongs to the thioredoxin family
HPY16_11885	COG0513	Belongs to the DEAD box helicase family
HPY16_11895	COG0784	Response regulator, receiver
HPY16_11895	COG2205	protein histidine kinase activity
HPY16_11900	COG2814	Major facilitator Superfamily
HPY16_11915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY16_11920	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HPY16_11925	COG0511	ligase activity, forming carbon-carbon bonds
HPY16_11930	COG0439	Biotin carboxylase
HPY16_11935	COG2264	protein methyltransferase activity
HPY16_11940	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY16_11945	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HPY16_11955	COG1609	Transcriptional regulator
HPY16_11965	COG0387	Pfam Sodium calcium exchanger
HPY16_11970	COG0129	dihydroxy-acid dehydratase activity
HPY16_11975	COG3265	gluconokinase activity
HPY16_11985	COG0800	Aldolase
HPY16_12005	COG0840	transmembrane signaling receptor activity
HPY16_12010	COG1982	Orn Lys Arg decarboxylase major
HPY16_12015	COG0531	amino acid
HPY16_12020	COG3710	Transcriptional regulator
HPY16_12025	COG0789	Transcriptional regulator
HPY16_12040	COG0151	Belongs to the GarS family
HPY16_12050	COG0776	regulation of translation
HPY16_12055	COG1253	flavin adenine dinucleotide binding
HPY16_12060	COG3068	Protein conserved in bacteria
HPY16_12070	COG1573	uracil-dna glycosylase
HPY16_12075	COG0668	transmembrane transport
HPY16_12095	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HPY16_12105	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPY16_12115	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY16_12175	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPY16_12180	COG0367	asparagine synthase
HPY16_12190	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HPY16_12190	COG2755	lipolytic protein G-D-S-L family
HPY16_12205	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPY16_12215	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HPY16_12220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY16_12245	COG0859	PFAM glycosyl transferase family 9
HPY16_12255	COG1519	Transferase
HPY16_12280	COG3642	lipopolysaccharide core region biosynthetic process
HPY16_12285	COG0859	PFAM glycosyl transferase family 9
HPY16_12290	COG0463	Glycosyl transferase, family 2
HPY16_12295	COG0859	PFAM glycosyl transferase family 9
HPY16_12300	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPY16_12305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HPY16_12315	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPY16_12320	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HPY16_12325	COG2003	Belongs to the UPF0758 family
HPY16_12330	COG0840	transmembrane signaling receptor activity
HPY16_12335	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPY16_12345	COG1309	transcriptional regulator
HPY16_12350	COG1560	Kdo2-lipid A biosynthetic process
HPY16_12355	COG1560	Kdo2-lipid A biosynthetic process
HPY16_12360	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPY16_12365	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HPY16_12370	COG1561	YicC-like family, N-terminal region
HPY16_12375	COG2862	Uncharacterized protein family, UPF0114
HPY16_12380	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY16_12385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY16_12385	COG1263	PTS System
HPY16_12390	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY16_12405	COG0514	ATP-dependent DNA helicase (RecQ)
HPY16_12410	COG2962	Rard protein
HPY16_12415	COG0405	Gamma-glutamyltransferase
HPY16_12425	COG1280	lysine exporter protein (LysE YggA)
HPY16_12430	COG0210	DNA helicase
HPY16_12440	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HPY16_12445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY16_12450	COG2131	deaminase
HPY16_12460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY16_12470	COG0747	negative chemotaxis
HPY16_12520	COG1309	transcriptional regulator
HPY16_12525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY16_12530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY16_12535	COG2960	long-chain fatty acid transporting porin activity
HPY16_12540	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPY16_12545	COG0583	DNA-binding transcription factor activity
HPY16_12615	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HPY16_12620	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY16_12625	COG1739	Uncharacterized protein family UPF0029
HPY16_12630	COG1024	Enoyl-CoA hydratase
HPY16_12630	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY16_12635	COG0183	Belongs to the thiolase family
HPY16_12640	COG0583	DNA-binding transcription factor activity
HPY16_12645	COG2814	Major facilitator Superfamily
HPY16_12655	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPY16_12660	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HPY16_12665	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPY16_12670	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPY16_12675	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPY16_12680	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HPY16_12690	COG0356	it plays a direct role in the translocation of protons across the membrane
HPY16_12695	COG3312	ion transport
HPY16_12700	COG1475	DNA binding
HPY16_12705	COG1192	Involved in chromosome partitioning
HPY16_12710	COG0357	Ribosomal RNA small subunit methyltransferase G
HPY16_12715	COG0445	tRNA wobble uridine modification
HPY16_12720	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY16_12725	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPY16_12730	COG0706	membrane insertase activity
HPY16_12740	COG0594	ribonuclease P activity
HPY16_12745	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPY16_12750	COG1126	abc transporter atp-binding protein
HPY16_12795	COG0217	transcriptional regulatory protein
HPY16_12800	COG2084	Dehydrogenase
HPY16_12815	COG2909	trisaccharide binding
HPY16_12820	COG0058	SHG alpha-glucan phosphorylase activity
HPY16_12825	COG1640	4-alpha-glucanotransferase
HPY16_12830	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HPY16_12840	COG3501	Rhs element vgr protein
HPY16_12875	COG0471	metal ion transport
HPY16_12880	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY16_12910	COG0671	phosphoesterase, PA-phosphatase related
HPY16_12920	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HPY16_12930	COG1999	signal sequence binding
HPY16_12945	COG0786	glutamate:sodium symporter activity
HPY16_12965	COG1566	PFAM secretion protein HlyD family protein
HPY16_12975	COG3706	GGDEF domain
HPY16_12990	COG0813	purine-nucleoside phosphorylase activity
HPY16_12995	COG3272	Protein of unknown function (DUF1722)
HPY16_13005	COG0415	Belongs to the DNA photolyase family
HPY16_13010	COG1376	ErfK ybiS ycfS ynhG family protein
HPY16_13010	COG1388	LysM domain
HPY16_13020	COG0513	Belongs to the DEAD box helicase family
HPY16_13025	COG1770	oligopeptidase
HPY16_13050	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY16_13055	COG0573	inorganic phosphate transmembrane transporter activity
HPY16_13060	COG0581	inorganic phosphate transmembrane transporter activity
HPY16_13065	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY16_13090	COG0659	secondary active sulfate transmembrane transporter activity
HPY16_13100	COG0739	heme binding
HPY16_13105	COG3300	MHYT domain
HPY16_13105	COG5001	Diguanylate cyclase
HPY16_13110	COG0583	DNA-binding transcription factor activity
HPY16_13115	COG2814	Major facilitator Superfamily
HPY16_13135	COG1301	dicarboxylic acid transport
HPY16_13150	COG1342	Belongs to the UPF0251 family
HPY16_13185	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPY16_13190	COG0673	inositol 2-dehydrogenase activity
HPY16_13200	COG2200	EAL domain
HPY16_13200	COG2771	luxR family
HPY16_13205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY16_13215	COG0564	pseudouridine synthase activity
HPY16_13325	COG1869	D-ribose catabolic process
HPY16_13330	COG1129	ABC transporter
HPY16_13335	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPY16_13340	COG1879	ABC-type sugar transport system periplasmic component
HPY16_13345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY16_13350	COG1609	Transcriptional regulator
HPY16_13360	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY16_13370	COG0584	glycerophosphoryl diester phosphodiesterase
HPY16_13375	COG2271	Major facilitator Superfamily
HPY16_13410	COG0579	oxidoreductase
HPY16_13420	COG0242	peptide deformylase activity
HPY16_13435	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY16_13445	COG1017	nitric oxide dioxygenase activity
HPY16_13445	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY16_13450	COG1320	monovalent cation:proton antiporter activity
HPY16_13455	COG2212	antiporter activity
HPY16_13475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY16_13475	COG2111	Na H antiporter
HPY16_13485	COG0589	response to stress
HPY16_13490	COG0814	amino acid
HPY16_13505	COG3530	Putative quorum-sensing-regulated virulence factor
HPY16_13515	COG5002	protein histidine kinase activity
HPY16_13515	COG5001	Diguanylate cyclase
HPY16_13520	COG1278	Cold shock
HPY16_13535	COG2304	oxidoreductase activity
HPY16_13555	COG0714	Associated with various cellular activities
HPY16_13560	COG0840	transmembrane signaling receptor activity
HPY16_13575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY16_13580	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY16_13590	COG3604	Transcriptional regulator
HPY16_13595	COG1017	nitric oxide dioxygenase activity
HPY16_13595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY16_13600	COG1278	Cold shock
HPY16_13605	COG3036	rescue of stalled ribosome
HPY16_13630	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPY16_13630	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPY16_13635	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY16_13645	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY16_13655	COG0516	GMP reductase activity
HPY16_13680	COG0513	Belongs to the DEAD box helicase family
HPY16_13685	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY16_13690	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HPY16_13695	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HPY16_13700	COG3437	response regulator, receiver
HPY16_13700	COG0784	Response regulator, receiver
HPY16_13710	COG4191	Histidine kinase
HPY16_13710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY16_13720	COG1757	Na H antiporter
HPY16_13725	COG2814	Major facilitator Superfamily
HPY16_13735	COG3240	lipase activity
HPY16_13745	COG0840	transmembrane signaling receptor activity
HPY16_13750	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HPY16_13755	COG5380	lipid catabolic process
HPY16_13785	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY16_13790	COG4605	iron ion homeostasis
HPY16_13795	COG4604	ABC transporter, ATP-binding protein
HPY16_13800	COG2207	Transcriptional regulator
HPY16_13815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY16_13820	COG0640	Transcriptional regulator
HPY16_13825	COG0798	PFAM Bile acid sodium symporter
HPY16_13840	COG0583	DNA-binding transcription factor activity
HPY16_13855	COG0745	RESPONSE REGULATOR receiver
HPY16_13865	COG3623	hexulose-6-phosphate isomerase
HPY16_13870	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HPY16_13875	COG0561	phosphatase activity
HPY16_13910	COG0366	Alpha amylase catalytic
HPY16_13930	COG0745	RESPONSE REGULATOR receiver
HPY16_13935	COG5002	protein histidine kinase activity
HPY16_13960	COG0583	DNA-binding transcription factor activity
HPY16_13975	COG1686	Belongs to the peptidase S11 family
HPY16_13995	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY16_13995	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY16_14000	COG0509	glycine decarboxylation via glycine cleavage system
HPY16_14005	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY16_14015	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HPY16_14030	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HPY16_14035	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPY16_14185	COG3549	Plasmid maintenance system killer
HPY16_14190	COG3093	addiction module antidote protein HigA
HPY16_14340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY16_14400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY16_14600	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPY16_14720	COG0346	lactoylglutathione lyase activity
HPY16_14785	COG3549	Plasmid maintenance system killer
HPY16_14790	COG3093	addiction module antidote protein HigA
HPY16_14850	COG2161	toxin-antitoxin pair type II binding
HPY16_14855	COG4115	mRNA cleavage
HPY16_14940	COG2026	Addiction module toxin, RelE StbE family
HPY16_15000	COG0653	protein targeting
HPY16_15030	COG5642	Protein of unknown function (DUF2384)
HPY16_15060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY16_15090	COG1418	mRNA catabolic process
HPY16_15295	COG0494	nUDIX hydrolase
HPY16_15415	COG3613	nucleoside 2-deoxyribosyltransferase
HPY16_15440	COG0653	protein targeting
HPY16_15470	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPY16_15550	COG0456	acetyltransferase
HPY16_15575	COG3040	lipid binding
HPY16_15585	COG1028	Short-chain dehydrogenase reductase Sdr
HPY16_15705	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY16_15705	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY16_15770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY16_15810	COG0346	lactoylglutathione lyase activity
HPY16_15815	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPY16_15835	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HPY16_15840	COG2944	sequence-specific DNA binding
HPY16_15870	COG3549	Plasmid maintenance system killer
HPY16_15875	COG3093	addiction module antidote protein HigA
HPY16_15915	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY16_15920	COG2885	chlorophyll binding
HPY16_15925	COG0840	transmembrane signaling receptor activity
HPY16_15930	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY16_15935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY16_15940	COG1621	beta-fructofuranosidase activity
HPY16_15950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY16_15950	COG1263	PTS System
HPY16_15995	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY16_16035	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HPY16_16040	COG0583	DNA-binding transcription factor activity
HPY16_16065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY16_16100	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY16_16110	COG2390	Transcriptional regulator
HPY16_16115	COG2897	thiosulfate sulfurtransferase activity
HPY16_16125	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY16_16135	COG0302	gtp cyclohydrolase
HPY16_16140	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY16_16140	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY16_16145	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HPY16_16150	COG1970	mechanosensitive ion channel activity
HPY16_16155	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HPY16_16165	COG1011	Hydrolase
HPY16_16170	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY16_16175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY16_16185	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY16_16190	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY16_16195	COG3842	ATPase activity
HPY16_16215	COG3104	oligopeptide transport
HPY16_16240	COG4166	transmembrane transport
HPY16_16245	COG4174	ABC transporter (Permease)
HPY16_16250	COG4239	(ABC) transporter, permease
HPY16_16255	COG4172	Belongs to the ABC transporter superfamily
HPY16_16260	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPY16_16275	COG0625	glutathione transferase activity
HPY16_16295	COG2050	protein possibly involved in aromatic compounds catabolism
HPY16_16310	COG4771	TonB-dependent receptor
HPY16_16315	COG0583	DNA-binding transcription factor activity
HPY16_16320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY16_16320	COG1042	CoA-binding domain protein
HPY16_16320	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY16_16340	COG0023	Translation Initiation Factor
HPY16_16345	COG3140	Belongs to the UPF0181 family
HPY16_16360	COG0745	RESPONSE REGULATOR receiver
HPY16_16370	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HPY16_16375	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HPY16_16390	COG3706	GGDEF domain
HPY16_16440	COG2824	Alkylphosphonate utilization operon protein PhnA
HPY16_16455	COG0737	Belongs to the 5'-nucleotidase family
HPY16_16460	COG3593	DNA synthesis involved in DNA repair
HPY16_16470	COG0583	DNA-binding transcription factor activity
HPY16_16475	COG2116	formate transmembrane transporter activity
HPY16_16485	COG3038	cytochrome b561
HPY16_16495	COG2200	EAL domain
HPY16_16510	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY16_16515	COG0745	RESPONSE REGULATOR receiver
HPY16_16520	COG2205	protein histidine kinase activity
HPY16_16525	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPY16_16525	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPY16_16525	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPY16_16525	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPY16_16530	COG3158	transport of potassium into the cell
HPY16_16540	COG0523	cobalamin synthesis protein
HPY16_16545	COG0038	chloride channel
HPY16_16555	COG0156	8-amino-7-oxononanoate synthase activity
HPY16_16565	COG0419	ATPase involved in DNA repair
HPY16_16570	COG0420	3'-5' exonuclease activity
HPY16_16575	COG1609	Transcriptional regulator
HPY16_16580	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY16_16580	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY16_16585	COG1105	Belongs to the carbohydrate kinase PfkB family
HPY16_16590	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY16_16590	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HPY16_16590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY16_16595	COG4067	protein conserved in archaea
HPY16_16595	COG0189	ligase activity
HPY16_16605	COG0602	queuosine metabolic process
HPY16_16610	COG1328	CTP reductase activity
HPY16_16620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY16_16625	COG0840	transmembrane signaling receptor activity
HPY16_16630	COG3069	C4-dicarboxylate transmembrane transporter activity
HPY16_16635	COG1760	l-serine dehydratase
HPY16_16640	COG2197	response regulator
HPY16_16645	COG3850	Histidine kinase
HPY16_16650	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY16_16660	COG0243	molybdopterin cofactor binding
HPY16_16680	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY16_16685	COG2197	response regulator
HPY16_16690	COG3851	Histidine kinase
HPY16_16695	COG2271	Major facilitator Superfamily
HPY16_16700	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY16_16710	COG3842	ATPase activity
HPY16_16715	COG3243	poly(R)-hydroxyalkanoic acid synthase
HPY16_16725	COG0183	Belongs to the thiolase family
HPY16_16735	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY16_16740	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY16_16755	COG3706	GGDEF domain
HPY16_16760	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY16_16770	COG1979	alcohol dehydrogenase
HPY16_16785	COG4191	Histidine kinase
HPY16_16795	COG2271	Major facilitator Superfamily
HPY16_16800	COG0469	pyruvate kinase activity
HPY16_16810	COG1879	ABC-type sugar transport system periplasmic component
HPY16_16815	COG1803	Methylglyoxal synthase
HPY16_16820	COG1335	isochorismatase
HPY16_16825	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPY16_16830	COG0210	DNA helicase
HPY16_16835	COG1289	transmembrane transporter activity
HPY16_16865	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HPY16_16870	COG4149	molybdate abc transporter
HPY16_16875	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPY16_16880	COG1492	cobalamin metabolic process
HPY16_16910	COG1917	Cupin 2, conserved barrel domain protein
HPY16_16910	COG4977	sequence-specific DNA binding
HPY16_16920	COG2814	Major facilitator Superfamily
HPY16_16925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY16_16925	COG3433	isochorismatase activity
HPY16_16925	COG2226	methyltransferase
HPY16_16950	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY16_16955	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY16_16975	COG1132	(ABC) transporter
HPY16_16980	COG1132	(ABC) transporter
HPY16_16990	COG0784	Response regulator, receiver
HPY16_16990	COG5002	protein histidine kinase activity
HPY16_16995	COG1879	ABC-type sugar transport system periplasmic component
HPY16_17005	COG2827	Endonuclease containing a URI domain
HPY16_17010	COG3132	Protein of unknown function, DUF480
HPY16_17020	COG2926	Belongs to the UPF0265 family
HPY16_17030	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HPY16_17035	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPY16_17040	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY16_17050	COG0247	lactate metabolic process
HPY16_17055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY16_17060	COG3118	belongs to the thioredoxin family
HPY16_17085	COG4160	amino acid transport
HPY16_17090	COG4215	(ABC) transporter
HPY16_17095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY16_17100	COG1126	abc transporter atp-binding protein
HPY16_17110	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HPY16_17120	COG0494	nUDIX hydrolase
HPY16_17125	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HPY16_17135	COG1309	transcriptional regulator
HPY16_17140	COG0513	Belongs to the DEAD box helicase family
HPY16_17145	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HPY16_17150	COG0814	amino acid
HPY16_17160	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPY16_17165	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HPY16_17170	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HPY16_17175	COG1984	allophanate hydrolase subunit 2
HPY16_17190	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HPY16_17195	COG4181	ATPase activity
HPY16_17205	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY16_17210	COG1716	ATPase activity
HPY16_17210	COG5001	Diguanylate cyclase
HPY16_17220	COG0484	heat shock protein binding
HPY16_17235	COG0546	phosphoglycolate phosphatase activity
HPY16_17250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY16_17260	COG0513	Belongs to the DEAD box helicase family
HPY16_17275	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY16_17285	COG3046	protein related to deoxyribodipyrimidine photolyase
HPY16_17290	COG3397	chitin binding
HPY16_17295	COG3227	Zinc metalloprotease (Elastase)
HPY16_17310	COG1166	arginine decarboxylase activity
HPY16_17320	COG2239	Acts as a magnesium transporter
HPY16_17330	COG0527	aspartate kinase activity
HPY16_17335	COG0662	Cupin 2, conserved barrel domain protein
HPY16_17340	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPY16_17345	COG0456	acetyltransferase
HPY16_17350	COG2154	pterin-4-alpha-carbinolamine dehydratase
HPY16_17355	COG3186	Phenylalanine-4-hydroxylase
HPY16_17360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY16_17375	COG2264	protein methyltransferase activity
HPY16_17400	COG1253	flavin adenine dinucleotide binding
HPY16_17405	COG1765	OsmC-like protein
HPY16_17450	COG1765	OsmC-like protein
HPY16_17480	COG1252	NADH dehydrogenase
HPY16_17485	COG0531	amino acid
HPY16_17490	COG3706	GGDEF domain
HPY16_17500	COG4989	oxidoreductase activity
HPY16_17505	COG0366	Alpha amylase catalytic
HPY16_17515	COG2067	long-chain fatty acid transport protein
HPY16_17520	COG2267	carboxylic ester hydrolase activity
HPY16_17530	COG3227	Zinc metalloprotease (Elastase)
HPY16_17535	COG3047	cAMP biosynthetic process
HPY16_17545	COG1686	Belongs to the peptidase S11 family
HPY16_17550	COG0557	exoribonuclease II activity
HPY16_17555	COG1278	Cold shock
HPY16_17565	COG3048	D-serine ammonia-lyase activity
HPY16_17570	COG0583	DNA-binding transcription factor activity
HPY16_17595	COG5002	protein histidine kinase activity
HPY16_17620	COG0582	viral genome integration into host DNA
HPY16_17640	COG1063	alcohol dehydrogenase
HPY16_17645	COG0156	8-amino-7-oxononanoate synthase activity
HPY16_17665	COG0346	lactoylglutathione lyase activity
HPY16_17685	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HPY16_17690	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY16_17695	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPY16_17700	COG0363	glucosamine-6-phosphate deaminase activity
HPY16_17705	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPY16_17730	COG1929	Belongs to the glycerate kinase type-1 family
HPY16_17735	COG2610	gluconate transmembrane transporter activity
HPY16_17740	COG3835	regulator
HPY16_17750	COG0748	coenzyme F420 binding
HPY16_17755	COG3721	Heme iron utilization protein
HPY16_17765	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY16_17770	COG0811	peptide transport
HPY16_17775	COG0848	biopolymer transport protein
HPY16_17780	COG4558	Periplasmic binding protein
HPY16_17785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY16_17790	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPY16_17825	COG3217	Mosc domain protein beta barrel domain protein
HPY16_17825	COG0633	Ferredoxin
HPY16_17825	COG3217	Mosc domain protein beta barrel domain protein
HPY16_17825	COG0633	Ferredoxin
HPY16_17830	COG0418	dihydroorotase activity
HPY16_17835	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY16_17840	COG2354	Protein conserved in bacteria
HPY16_17850	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY16_17855	COG1278	Cold shock
HPY16_17880	COG3706	GGDEF domain
HPY16_17885	COG1349	DNA-binding transcription factor activity
HPY16_17900	COG3833	ABC-type maltose transport systems, permease component
HPY16_17905	COG1175	transmembrane transport
HPY16_17915	COG3842	ATPase activity
HPY16_17920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY16_17935	COG0393	Putative heavy-metal-binding
HPY16_17945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY16_17950	COG0784	Response regulator, receiver
HPY16_17950	COG0835	chemotaxis
HPY16_17955	COG1846	Transcriptional regulator
HPY16_17960	COG3706	GGDEF domain
HPY16_17995	COG0583	DNA-binding transcription factor activity
HPY16_18000	COG5001	Diguanylate cyclase
HPY16_18010	COG1741	Belongs to the pirin family
HPY16_18015	COG3123	guanosine phosphorylase activity
HPY16_18025	COG2211	Major facilitator Superfamily
HPY16_18035	COG1067	ATP-dependent peptidase activity
HPY16_18045	COG4172	Belongs to the ABC transporter superfamily
HPY16_18065	COG0583	DNA-binding transcription factor activity
HPY16_18075	COG1620	l-lactate permease
HPY16_18090	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HPY16_18100	COG0840	transmembrane signaling receptor activity
HPY16_18120	COG2258	MOSC domain
HPY16_18125	COG0513	Belongs to the DEAD box helicase family
HPY16_18135	COG2186	Transcriptional regulator
HPY16_18145	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY16_18155	COG0246	Mannitol dehydrogenase
HPY16_18160	COG1904	glucuronate isomerase
HPY16_18165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY16_18170	COG0800	Aldolase
HPY16_18180	COG0583	DNA-binding transcription factor activity
HPY16_18190	COG1902	pentaerythritol trinitrate reductase activity
HPY16_18200	COG1132	(ABC) transporter
HPY16_18210	COG1902	pentaerythritol trinitrate reductase activity
HPY16_18220	COG1280	lysine exporter protein (LysE YggA)
HPY16_18225	COG2207	Transcriptional regulator
HPY16_18245	COG1846	Transcriptional regulator
HPY16_18250	COG1764	response to oxidative stress
HPY16_18255	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY16_18260	COG0697	spore germination
HPY16_18270	COG0700	Nucleoside recognition
HPY16_18275	COG3366	ferrous iron transmembrane transporter activity
HPY16_18280	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPY16_18290	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPY16_18305	COG2259	Doxx family
HPY16_18330	COG0363	glucosamine-6-phosphate deaminase activity
HPY16_18345	COG4580	involved in the transport of maltose and maltodextrins
HPY16_18360	COG0840	transmembrane signaling receptor activity
HPY16_18370	COG0840	transmembrane signaling receptor activity
HPY16_18375	COG3706	GGDEF domain
HPY16_18385	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY16_18390	COG1126	abc transporter atp-binding protein
HPY16_18400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY16_18405	COG4597	amino acid ABC transporter
HPY16_18410	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPY16_18415	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY16_18415	COG2213	PTS system mannitol-specific
HPY16_18420	COG0246	Mannitol dehydrogenase
HPY16_18425	COG3722	fumarate hydratase activity
HPY16_18460	COG2910	NAD(P)H-binding
HPY16_18470	COG0840	transmembrane signaling receptor activity
HPY16_18475	COG4221	oxidoreductase activity
HPY16_18485	COG1901	pseudouridine methyltransferase
HPY16_18500	COG0531	amino acid
HPY16_18505	COG1982	Orn Lys Arg decarboxylase major
HPY16_18515	COG2197	response regulator
HPY16_18565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY16_18590	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPY16_18655	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY16_18660	COG0840	transmembrane signaling receptor activity
HPY16_18665	COG0835	chemotaxis
HPY16_18670	COG0835	chemotaxis
HPY16_18675	COG0643	Histidine kinase
HPY16_18675	COG2198	Histidine kinase
HPY16_18695	COG0601	transmembrane transport
HPY16_18700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY16_18705	COG4608	Belongs to the ABC transporter superfamily
HPY16_18710	COG2194	sulfuric ester hydrolase activity
HPY16_18715	COG0642	Histidine kinase
HPY16_18720	COG0745	RESPONSE REGULATOR receiver
HPY16_18730	COG4221	oxidoreductase activity
HPY16_18750	COG1444	tRNA N-acetyltransferase activity
HPY16_18755	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine