locus-tag	class	description
VCM66_0002	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VCM66_0003	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VCM66_0004	COG0706	membrane insertase activity
VCM66_0005	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
VCM66_0006	COG0594	ribonuclease P activity
VCM66_0007	COG0230	Belongs to the bacterial ribosomal protein bL34 family
VCM66_0008	COG1126	abc transporter atp-binding protein
VCM66_0012	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VCM66_0013	COG0592	DNA-directed DNA polymerase activity
VCM66_0014	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VCM66_0015	COG0187	DNA topoisomerase II activity
VCM66_0018	COG0071	Belongs to the small heat shock protein (HSP20) family
VCM66_0019	COG3977	Valine--pyruvate aminotransferase
VCM66_0020	COG0751	glycine-tRNA ligase activity
VCM66_0021	COG0752	glycyl-tRNA synthetase alpha subunit
VCM66_0022	COG2119	membrane
VCM66_0024	COG0425	Belongs to the sulfur carrier protein TusA family
VCM66_0026	COG0604	alcohol dehydrogenase
VCM66_0028	COG0129	dihydroxy-acid dehydratase activity
VCM66_0029	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VCM66_0032	COG0606	chelatase, subunit chli
VCM66_0033	COG0204	Acyl-transferase
VCM66_0034	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VCM66_0035	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VCM66_0037	COG3084	Protein conserved in bacteria
VCM66_0039	COG4326	sporulation control protein
VCM66_0040	COG1272	protein, Hemolysin III
VCM66_0042	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VCM66_0043	COG0569	domain protein
VCM66_0044	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VCM66_0044	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VCM66_0046	COG0242	peptide deformylase activity
VCM66_0047	COG1652	LysM domain
VCM66_0048	COG0758	DNA mediated transformation
VCM66_0049	COG2922	Belongs to the Smg family
VCM66_0050	COG0551	DNA topoisomerase type I activity
VCM66_0051	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VCM66_0052	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VCM66_0054	COG0009	L-threonylcarbamoyladenylate synthase
VCM66_0056	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VCM66_0058	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VCM66_0060	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VCM66_0061	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VCM66_0063	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VCM66_0064	COG2104	thiamine diphosphate biosynthetic process
VCM66_0065	COG2022	thiamine diphosphate biosynthetic process
VCM66_0066	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VCM66_0067	COG0006	proline dipeptidase activity
VCM66_0067	COG0006	proline dipeptidase activity
VCM66_0071	COG1522	sequence-specific DNA binding
VCM66_0072	COG5002	protein histidine kinase activity
VCM66_0072	COG5001	Diguanylate cyclase
VCM66_0073	COG0742	ribosomal rna small subunit methyltransferase
VCM66_0075	COG0697	spore germination
VCM66_0076	COG0589	response to stress
VCM66_0078	COG1528	Iron-storage protein
VCM66_0080	COG2081	HI0933 family
VCM66_0082	COG1322	Protein conserved in bacteria
VCM66_0083	COG2226	methyltransferase
VCM66_0085	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VCM66_0086	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VCM66_0087	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VCM66_0088	COG0805	protein transport
VCM66_0089	COG1858	cytochrome C peroxidase
VCM66_0090	COG0534	Mate efflux family protein
VCM66_0092	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VCM66_0093	COG2937	Belongs to the GPAT DAPAT family
VCM66_0094	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VCM66_0095	COG3161	chorismate lyase activity
VCM66_0097	COG1580	Controls the rotational direction of flagella during chemotaxis
VCM66_0098	COG0840	transmembrane signaling receptor activity
VCM66_0100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VCM66_0103	COG0084	hydrolase, TatD family'
VCM66_0108	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VCM66_0108	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VCM66_0111	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VCM66_0114	COG3078	GTPase activator activity
VCM66_0116	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VCM66_0117	COG3071	HemY protein
VCM66_0118	COG2959	enzyme of heme biosynthesis
VCM66_0119	COG1587	Uroporphyrinogen-III synthase
VCM66_0120	COG0181	hydroxymethylbilane synthase activity
VCM66_0122	COG3072	Adenylate cyclase
VCM66_0123	COG1965	Belongs to the frataxin family
VCM66_0125	COG0019	diaminopimelate decarboxylase activity
VCM66_0126	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VCM66_0128	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VCM66_0129	COG1011	Hydrolase
VCM66_0130	COG2199	diguanylate cyclase activity
VCM66_0130	COG3287	FIST C domain
VCM66_0130	COG2200	EAL domain
VCM66_0134	COG0561	phosphatase activity
VCM66_0135	COG2267	carboxylic ester hydrolase activity
VCM66_0136	COG1280	lysine exporter protein (LysE YggA)
VCM66_0137	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VCM66_0139	COG0783	Belongs to the Dps family
VCM66_0146	COG0742	ribosomal rna small subunit methyltransferase
VCM66_0147	COG0552	protein localization to endoplasmic reticulum
VCM66_0148	COG2884	Cell division ATP-binding protein ftsE
VCM66_0149	COG2177	Part of the ABC transporter FtsEX involved in
VCM66_0150	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VCM66_0151	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VCM66_0154	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VCM66_0155	COG4206	TonB-dependent receptor
VCM66_0156	COG1404	Belongs to the peptidase S8 family
VCM66_0157	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VCM66_0160	COG0583	DNA-binding transcription factor activity
VCM66_0161	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VCM66_0162	COG2960	long-chain fatty acid transporting porin activity
VCM66_0163	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VCM66_0164	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCM66_0165	COG1309	transcriptional regulator
VCM66_0170	COG0747	negative chemotaxis
VCM66_0172	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VCM66_0174	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VCM66_0175	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VCM66_0178	COG0210	DNA helicase
VCM66_0179	COG1280	lysine exporter protein (LysE YggA)
VCM66_0183	COG2962	Rard protein
VCM66_0184	COG0514	ATP-dependent DNA helicase (RecQ)
VCM66_0187	COG1132	(ABC) transporter
VCM66_0188	COG4774	siderophore transport
VCM66_0189	COG1120	ATPase activity
VCM66_0194	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VCM66_0195	COG1263	PTS System
VCM66_0195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VCM66_0197	COG1561	YicC-like family, N-terminal region
VCM66_0198	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VCM66_0199	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VCM66_0201	COG1560	Kdo2-lipid A biosynthetic process
VCM66_0202	COG1309	transcriptional regulator
VCM66_0203	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VCM66_0206	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VCM66_0207	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VCM66_0209	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VCM66_0210	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VCM66_0211	COG0859	PFAM glycosyl transferase family 9
VCM66_0212	COG0463	Glycosyl transferase, family 2
VCM66_0213	COG0859	PFAM glycosyl transferase family 9
VCM66_0215	COG3642	lipopolysaccharide core region biosynthetic process
VCM66_0221	COG1519	Transferase
VCM66_0228	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VCM66_0229	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
VCM66_0229	COG0662	Cupin 2, conserved barrel domain protein
VCM66_0230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VCM66_0231	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
VCM66_0237	COG0318	PFAM AMP-dependent synthetase and ligase
VCM66_0238	COG1454	alcohol dehydrogenase
VCM66_0238	COG1012	belongs to the aldehyde dehydrogenase family
VCM66_0248	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VCM66_0249	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VCM66_0250	COG0668	transmembrane transport
VCM66_0251	COG1573	uracil-dna glycosylase
VCM66_0253	COG3068	Protein conserved in bacteria
VCM66_0255	COG1940	carbohydrate kinase activity
VCM66_0256	COG1253	flavin adenine dinucleotide binding
VCM66_0258	COG0776	regulation of translation
VCM66_0260	COG0151	Belongs to the GarS family
VCM66_0261	COG0138	bifunctional purine biosynthesis protein purh
VCM66_0262	COG0789	Transcriptional regulator
VCM66_0263	COG3710	Transcriptional regulator
VCM66_0265	COG0531	amino acid
VCM66_0266	COG1982	Orn Lys Arg decarboxylase major
VCM66_0267	COG0840	transmembrane signaling receptor activity
VCM66_0270	COG0800	Aldolase
VCM66_0272	COG3265	gluconokinase activity
VCM66_0273	COG0129	dihydroxy-acid dehydratase activity
VCM66_0274	COG1609	Transcriptional regulator
VCM66_0275	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VCM66_0276	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VCM66_0280	COG0439	Biotin carboxylase
VCM66_0281	COG0511	ligase activity, forming carbon-carbon bonds
VCM66_0282	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VCM66_0283	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VCM66_0287	COG2814	Major facilitator Superfamily
VCM66_0288	COG2205	protein histidine kinase activity
VCM66_0288	COG0784	Response regulator, receiver
VCM66_0289	COG0248	Ppx GppA phosphatase
VCM66_0290	COG0513	Belongs to the DEAD box helicase family
VCM66_0291	COG3118	belongs to the thioredoxin family
VCM66_0292	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
VCM66_0294	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VCM66_0299	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VCM66_0302	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VCM66_0304	COG1072	(Pantothenic acid kinase))
VCM66_0305	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VCM66_0306	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VCM66_0307	COG0250	Participates in transcription elongation, termination and antitermination
VCM66_0308	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VCM66_0309	COG0081	regulation of translation
VCM66_0310	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VCM66_0311	COG0222	ribosome binding
VCM66_0312	COG0085	RNA polymerase activity
VCM66_0313	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VCM66_0314	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VCM66_0315	COG2816	NAD+ diphosphatase activity
VCM66_0316	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VCM66_0319	COG4942	peptidase
VCM66_0320	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VCM66_0322	COG0471	metal ion transport
VCM66_0322	COG0490	domain, Protein
VCM66_0323	COG0688	phosphatidylethanolamine metabolic process
VCM66_0324	COG1162	GTPase activity
VCM66_0325	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VCM66_0326	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VCM66_0327	COG0802	atpase or kinase
VCM66_0329	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VCM66_0330	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VCM66_0331	COG1923	regulation of RNA biosynthetic process
VCM66_0332	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VCM66_0333	COG0330	HflC and HflK could
VCM66_0334	COG0330	HflC and HflK could
VCM66_0335	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VCM66_0336	COG2900	Belongs to the SlyX family
VCM66_0338	COG0545	Peptidyl-prolyl cis-trans isomerase
VCM66_0339	COG2964	Protein conserved in bacteria
VCM66_0340	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VCM66_0341	COG2923	Belongs to the DsrF TusC family
VCM66_0343	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
VCM66_0344	COG0049	tRNA binding
VCM66_0345	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VCM66_0346	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VCM66_0348	COG2906	2 iron, 2 sulfur cluster binding
VCM66_0350	COG0360	Binds together with S18 to 16S ribosomal RNA
VCM66_0351	COG2965	DNA replication, synthesis of RNA primer
VCM66_0352	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
VCM66_0353	COG0359	binds to the 23S rRNA
VCM66_0355	COG0305	Participates in initiation and elongation during chromosome replication
VCM66_0356	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VCM66_0357	COG0432	Pfam Uncharacterised protein family UPF0047
VCM66_0358	COG0166	Belongs to the GPI family
VCM66_0362	COG0735	belongs to the Fur family
VCM66_0363	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VCM66_0369	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VCM66_0370	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VCM66_0371	COG0175	sulfate reduction
VCM66_0375	COG0646	methionine synthase
VCM66_0375	COG1410	methionine synthase
VCM66_0376	COG0527	aspartate kinase activity
VCM66_0377	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VCM66_0379	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VCM66_0382	COG0629	single-stranded DNA binding
VCM66_0383	COG2200	EAL domain
VCM66_0383	COG2199	diguanylate cyclase activity
VCM66_0388	COG3409	Peptidoglycan-binding domain 1 protein
VCM66_0388	COG3267	Type II secretory pathway component ExeA
VCM66_0390	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VCM66_0391	COG1459	type II secretion system
VCM66_0400	COG1077	Cell shape determining protein MreB Mrl
VCM66_0401	COG1792	Involved in formation and maintenance of cell shape
VCM66_0402	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VCM66_0403	COG0424	maF-like protein
VCM66_0404	COG1530	ribonuclease E activity
VCM66_0405	COG3164	Protein of unknown function
VCM66_0406	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VCM66_0407	COG0312	modulator of DNA gyrase
VCM66_0408	COG2235	arginine
VCM66_0413	COG0589	response to stress
VCM66_0416	COG1438	arginine binding
VCM66_0417	COG0039	L-malate dehydrogenase activity
VCM66_0418	COG0531	amino acid
VCM66_0419	COG0142	geranyltranstransferase activity
VCM66_0420	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VCM66_0421	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VCM66_0422	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VCM66_0423	COG2966	Psort location CytoplasmicMembrane, score
VCM66_0424	COG3610	response to peptide
VCM66_0426	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VCM66_0427	COG2967	ApaG domain
VCM66_0428	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VCM66_0429	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VCM66_0430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VCM66_0431	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VCM66_0432	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VCM66_0435	COG0741	lytic transglycosylase activity
VCM66_0436	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VCM66_0437	COG1194	a g-specific adenine glycosylase
VCM66_0438	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VCM66_0439	COG2066	Belongs to the glutaminase family
VCM66_0440	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VCM66_0441	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VCM66_0444	COG0762	integral membrane protein
VCM66_0445	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VCM66_0446	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VCM66_0450	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VCM66_0451	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VCM66_0452	COG1678	Uncharacterized ACR, COG1678
VCM66_0453	COG0189	ligase activity
VCM66_0454	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VCM66_0455	COG2356	endonuclease I
VCM66_0456	COG3091	SprT-like family
VCM66_0457	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VCM66_0458	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VCM66_0459	COG0583	DNA-binding transcription factor activity
VCM66_0460	COG4771	TonB-dependent receptor
VCM66_0461	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VCM66_0462	COG0126	phosphoglycerate kinase activity
VCM66_0463	COG0191	fructose-bisphosphate aldolase activity
VCM66_0465	COG0668	transmembrane transport
VCM66_0466	COG1279	arginine transmembrane transporter activity
VCM66_0467	COG0583	DNA-binding transcription factor activity
VCM66_0470	COG0469	pyruvate kinase activity
VCM66_0471	COG1349	DNA-binding transcription factor activity
VCM66_0472	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VCM66_0473	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VCM66_0475	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VCM66_0476	COG0358	DNA primase activity
VCM66_0477	COG1610	YqeY-like protein
VCM66_0478	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VCM66_0479	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VCM66_0481	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VCM66_0482	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VCM66_0483	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VCM66_0484	COG1968	undecaprenyl-diphosphatase activity
VCM66_0485	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VCM66_0486	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VCM66_0487	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VCM66_0488	COG0585	pseudouridine synthase activity
VCM66_0489	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VCM66_0490	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VCM66_0491	COG1388	LysM domain
VCM66_0491	COG4942	peptidase
VCM66_0492	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VCM66_0493	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VCM66_0498	COG4208	sulfate ABC transporter
VCM66_0499	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
VCM66_0501	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VCM66_0502	COG2137	regulation of response to DNA damage stimulus
VCM66_0503	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VCM66_0505	COG0527	aspartate kinase activity
VCM66_0506	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
VCM66_0507	COG3630	sodium ion export across plasma membrane
VCM66_0508	COG0511	ligase activity, forming carbon-carbon bonds
VCM66_0508	COG5016	pyruvate
VCM66_0509	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VCM66_0511	COG1238	metal cluster binding
VCM66_0512	COG0612	Peptidase, M16
VCM66_0514	COG2918	glutathione biosynthetic process
VCM66_0515	COG1854	S-ribosylhomocysteine lyase activity
VCM66_0516	COG4536	flavin adenine dinucleotide binding
VCM66_0517	COG4137	Cytochrome C assembly protein
VCM66_0518	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VCM66_0519	COG0228	four-way junction DNA binding
VCM66_0520	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VCM66_0521	COG0336	Belongs to the RNA methyltransferase TrmD family
VCM66_0522	COG0335	large ribosomal subunit rRNA binding
VCM66_0523	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VCM66_0524	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VCM66_0526	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VCM66_0528	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VCM66_0529	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VCM66_0531	COG0723	plastoquinol--plastocyanin reductase activity
VCM66_0532	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VCM66_0533	COG2857	Cytochrome c1
VCM66_0534	COG0625	glutathione transferase activity
VCM66_0535	COG2969	positive regulation of protein catabolic process
VCM66_0536	COG2823	Periplasmic or secreted lipoprotein
VCM66_0537	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VCM66_0538	COG0792	nuclease activity
VCM66_0539	COG3107	peptidoglycan biosynthetic process
VCM66_0540	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VCM66_0544	COG0288	reversible hydration of carbon dioxide
VCM66_0545	COG0659	secondary active sulfate transmembrane transporter activity
VCM66_0547	COG1131	(ABC) transporter
VCM66_0548	COG0842	Transport permease protein
VCM66_0549	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VCM66_0550	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VCM66_0551	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VCM66_0553	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VCM66_0554	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VCM66_0555	COG1489	DNA binding
VCM66_0560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VCM66_0561	COG1752	Esterase of the alpha-beta hydrolase superfamily
VCM66_0562	COG1049	propionate catabolic process, 2-methylcitrate cycle
VCM66_0563	COG3112	Uncharacterised protein family (UPF0231)
VCM66_0564	COG0347	Belongs to the P(II) protein family
VCM66_0565	COG0004	ammonium transporteR
VCM66_0566	COG1840	ABC-type Fe3 transport system, periplasmic component
VCM66_0568	COG3842	ATPase activity
VCM66_0572	COG2971	BadF BadG BcrA BcrD
VCM66_0574	COG4608	Belongs to the ABC transporter superfamily
VCM66_0575	COG0444	Belongs to the ABC transporter superfamily
VCM66_0576	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VCM66_0577	COG0601	transmembrane transport
VCM66_0578	COG0747	negative chemotaxis
VCM66_0581	COG2813	Specifically methylates the guanine in position
VCM66_0582	COG0628	permease
VCM66_0584	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VCM66_0585	COG0316	Belongs to the HesB IscA family
VCM66_0588	COG0739	heme binding
VCM66_0589	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VCM66_0590	COG2027	D-alanyl-D-alanine carboxypeptidase
VCM66_0591	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VCM66_0592	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VCM66_0593	COG1534	Rna-binding protein
VCM66_0594	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VCM66_0595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VCM66_0596	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VCM66_0597	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VCM66_0598	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VCM66_0599	COG0779	Required for maturation of 30S ribosomal subunits
VCM66_0600	COG0195	Participates in both transcription termination and antitermination
VCM66_0601	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VCM66_0602	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VCM66_0603	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VCM66_0604	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VCM66_0605	COG1185	polyribonucleotide nucleotidyltransferase activity
VCM66_0606	COG4785	May be involved in cell division
VCM66_0613	COG3153	acetyltransferase
VCM66_0617	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VCM66_0618	COG0513	Belongs to the DEAD box helicase family
VCM66_0619	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VCM66_0621	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VCM66_0622	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VCM66_0623	COG2204	response regulator
VCM66_0625	COG0667	Aldo Keto reductase
VCM66_0626	COG3066	DNA modification
VCM66_0629	COG0494	nUDIX hydrolase
VCM66_0630	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
VCM66_0631	COG0730	response to heat
VCM66_0632	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VCM66_0633	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VCM66_0634	COG1283	sodium-dependent phosphate transmembrane transporter activity
VCM66_0635	COG0583	DNA-binding transcription factor activity
VCM66_0636	COG0640	Transcriptional regulator
VCM66_0637	COG0268	Binds directly to 16S ribosomal RNA
VCM66_0638	COG0728	peptidoglycan biosynthetic process
VCM66_0639	COG0196	riboflavin kinase activity
VCM66_0640	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VCM66_0641	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VCM66_0642	COG1047	Peptidyl-prolyl cis-trans
VCM66_0643	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VCM66_0645	COG1966	Carbon starvation protein
VCM66_0648	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VCM66_0649	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VCM66_0650	COG1472	Belongs to the glycosyl hydrolase 3 family
VCM66_0651	COG3279	Response regulator of the LytR AlgR family
VCM66_0652	COG3275	phosphorelay sensor kinase activity
VCM66_0653	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VCM66_0654	COG0287	Prephenate dehydrogenase
VCM66_0654	COG1605	Chorismate mutase
VCM66_0656	COG0488	(ABC) transporter
VCM66_0659	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VCM66_0660	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VCM66_0661	COG5001	Diguanylate cyclase
VCM66_0662	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VCM66_0663	COG1605	Chorismate mutase
VCM66_0663	COG0077	Prephenate dehydratase
VCM66_0664	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VCM66_0666	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VCM66_0667	COG0564	pseudouridine synthase activity
VCM66_0669	COG0542	response to heat
VCM66_0674	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VCM66_0676	COG2974	May be involved in recombination
VCM66_0677	COG0745	RESPONSE REGULATOR receiver
VCM66_0678	COG5002	protein histidine kinase activity
VCM66_0680	COG0248	Ppx GppA phosphatase
VCM66_0681	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VCM66_0683	COG0581	inorganic phosphate transmembrane transporter activity
VCM66_0684	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VCM66_0688	COG3142	Participates in the control of copper homeostasis
VCM66_0689	COG0450	alkyl hydroperoxide reductase
VCM66_0690	COG0583	DNA-binding transcription factor activity
VCM66_0692	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VCM66_0695	COG0517	IMP dehydrogenase activity
VCM66_0697	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VCM66_0699	COG0343	queuine tRNA-ribosyltransferase activity
VCM66_0700	COG1862	Preprotein translocase
VCM66_0701	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VCM66_0702	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VCM66_0703	COG0483	inositol monophosphate 1-phosphatase activity
VCM66_0705	COG1959	2 iron, 2 sulfur cluster binding
VCM66_0707	COG0822	iron-sulfur transferase activity
VCM66_0711	COG0633	Ferredoxin
VCM66_0712	COG2975	iron-sulfur cluster assembly
VCM66_0713	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VCM66_0714	COG0105	UTP biosynthetic process
VCM66_0717	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VCM66_0718	COG0124	histidyl-tRNA synthetase
VCM66_0719	COG2976	Protein conserved in bacteria
VCM66_0720	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VCM66_0721	COG1160	GTP binding
VCM66_0724	COG1570	exodeoxyribonuclease VII activity
VCM66_0725	COG0517	IMP dehydrogenase activity
VCM66_0725	COG0516	GMP reductase activity
VCM66_0726	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VCM66_0726	COG0519	Catalyzes the synthesis of GMP from XMP
VCM66_0728	COG1584	GPR1 FUN34 yaaH family protein
VCM66_0729	COG3433	isochorismatase activity
VCM66_0729	COG1535	isochorismatase
VCM66_0730	COG1021	2,3-dihydroxybenzoate-AMP ligase
VCM66_0731	COG1169	isochorismate synthase
VCM66_0732	COG1028	Short-chain dehydrogenase reductase Sdr
VCM66_0734	COG4592	Periplasmic binding protein
VCM66_0735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VCM66_0736	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VCM66_0737	COG1120	ATPase activity
VCM66_0739	COG0583	DNA-binding transcription factor activity
VCM66_0741	COG2015	COG2015, Alkyl sulfatase and related hydrolases
VCM66_0742	COG1115	amino acid carrier protein
VCM66_0744	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VCM66_0745	COG0583	DNA-binding transcription factor activity
VCM66_0748	COG4565	transcriptional regulatory protein
VCM66_0750	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VCM66_0751	COG5016	pyruvate
VCM66_0751	COG0511	ligase activity, forming carbon-carbon bonds
VCM66_0752	COG3630	sodium ion export across plasma membrane
VCM66_0754	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
VCM66_0755	COG3052	prosthetic group binding
VCM66_0756	COG2301	Belongs to the HpcH HpaI aldolase family
VCM66_0757	COG3051	citrate lyase alpha subunit
VCM66_0758	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
VCM66_0759	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
VCM66_0761	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VCM66_0762	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VCM66_0764	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VCM66_0777	COG1012	belongs to the aldehyde dehydrogenase family
VCM66_0781	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
VCM66_0782	COG0840	transmembrane signaling receptor activity
VCM66_0783	COG3710	Transcriptional regulator
VCM66_0785	COG2165	general secretion pathway protein
VCM66_0788	COG4796	Type ii and iii secretion system protein
VCM66_0792	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VCM66_0793	COG1459	type II secretion system
VCM66_0795	COG2207	Transcriptional regulator
VCM66_0796	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
VCM66_0800	COG0739	heme binding
VCM66_0802	COG3064	Membrane
VCM66_0804	COG0582	viral genome integration into host DNA
VCM66_0805	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VCM66_0806	COG2867	negative regulation of translational initiation
VCM66_0807	COG2914	Belongs to the UPF0125 (RnfH) family
VCM66_0808	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VCM66_0809	COG0497	DNA recombination
VCM66_0810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VCM66_0811	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VCM66_0812	COG0443	Heat shock 70 kDa protein
VCM66_0813	COG0484	heat shock protein binding
VCM66_0815	COG4968	Prepilin-type N-terminal cleavage methylation domain
VCM66_0820	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VCM66_0821	COG0590	tRNA wobble adenosine to inosine editing
VCM66_0823	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VCM66_0826	COG0047	phosphoribosylformylglycinamidine synthase activity
VCM66_0826	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VCM66_0827	COG1943	Transposase
VCM66_0832	COG0442	prolyl-tRNA aminoacylation
VCM66_0833	COG1720	tRNA m6t6A37 methyltransferase activity
VCM66_0835	COG0254	rRNA binding
VCM66_0836	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VCM66_0837	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VCM66_0838	COG1671	Belongs to the UPF0178 family
VCM66_0841	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VCM66_0844	COG3098	single-species biofilm formation
VCM66_0845	COG0564	pseudouridine synthase activity
VCM66_0846	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VCM66_0847	COG0142	geranyltranstransferase activity
VCM66_0848	COG1722	exodeoxyribonuclease VII activity
VCM66_0849	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VCM66_0851	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VCM66_0851	COG0301	tRNA thio-modification
VCM66_0853	COG0583	DNA-binding transcription factor activity
VCM66_0854	COG2363	Small membrane protein
VCM66_0855	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VCM66_0856	COG1611	Belongs to the LOG family
VCM66_0857	COG3706	GGDEF domain
VCM66_0859	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VCM66_0859	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VCM66_0861	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VCM66_0862	COG1464	Belongs to the NlpA lipoprotein family
VCM66_0863	COG2011	ABC-type metal ion transport system permease component
VCM66_0864	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VCM66_0865	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VCM66_0866	COG1609	Transcriptional regulator
VCM66_0867	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VCM66_0867	COG1263	PTS System
VCM66_0868	COG0366	Alpha amylase catalytic
VCM66_0871	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VCM66_0873	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VCM66_0874	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VCM66_0875	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VCM66_0876	COG0110	maltose O-acetyltransferase activity
VCM66_0880	COG1045	serine acetyltransferase
VCM66_0882	COG0438	transferase activity, transferring glycosyl groups
VCM66_0884	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
VCM66_0890	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VCM66_0892	COG1596	polysaccharide export
VCM66_0897	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VCM66_0899	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VCM66_0900	COG0321	lipoyl(octanoyl) transferase activity
VCM66_0901	COG2921	Belongs to the UPF0250 family
VCM66_0903	COG1686	Belongs to the peptidase S11 family
VCM66_0904	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VCM66_0905	COG0772	Belongs to the SEDS family
VCM66_0906	COG0768	penicillin binding
VCM66_0907	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VCM66_0908	COG0799	negative regulation of ribosome biogenesis
VCM66_0909	COG1466	dna polymerase III delta subunit
VCM66_0910	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VCM66_0912	COG0495	leucyl-tRNA aminoacylation
VCM66_0913	COG2888	peptidyl-tyrosine sulfation
VCM66_0914	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VCM66_0915	COG4535	Mg2 and Co2 transporter CorC
VCM66_0916	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VCM66_0917	COG1702	phosphate starvation-inducible protein PhoH
VCM66_0918	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VCM66_0919	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VCM66_0920	COG2190	(PTS) system
VCM66_0922	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCM66_0924	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VCM66_0925	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VCM66_0926	COG3115	cell septum assembly
VCM66_0927	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VCM66_0930	COG0789	Transcriptional regulator
VCM66_0931	COG1585	Membrane protein implicated in regulation of membrane protease activity
VCM66_0932	COG0330	HflC and HflK could
VCM66_0933	COG3118	belongs to the thioredoxin family
VCM66_0935	COG0300	oxidoreductase activity
VCM66_0936	COG1090	epimerase
VCM66_0937	COG0622	Phosphoesterase
VCM66_0940	COG3710	Transcriptional regulator
VCM66_0941	COG0326	Molecular chaperone. Has ATPase activity
VCM66_0942	COG0563	adenylate kinase activity
VCM66_0943	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VCM66_0947	COG0367	asparagine synthase
VCM66_0948	COG4651	solute:proton antiporter activity
VCM66_0948	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VCM66_0949	COG1846	Transcriptional regulator
VCM66_0949	COG1940	carbohydrate kinase activity
VCM66_0950	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VCM66_0951	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VCM66_0951	COG1263	PTS System
VCM66_0951	COG2190	(PTS) system
VCM66_0953	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VCM66_0955	COG0101	tRNA pseudouridine synthase activity
VCM66_0956	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VCM66_0957	COG0285	dihydrofolate synthase activity
VCM66_0958	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VCM66_0959	COG1286	toxin biosynthetic process
VCM66_0960	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VCM66_0961	COG2056	Na+-H+ antiporter family
VCM66_0962	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VCM66_0966	COG0346	lactoylglutathione lyase activity
VCM66_0967	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VCM66_0968	COG4660	Part of a membrane complex involved in electron transport
VCM66_0969	COG4659	FMN binding
VCM66_0970	COG4658	electron transport chain
VCM66_0971	COG4656	Part of a membrane complex involved in electron transport
VCM66_0972	COG2878	Part of a membrane complex involved in electron transport
VCM66_0973	COG4657	Part of a membrane complex involved in electron transport
VCM66_0974	COG0556	nucleotide-excision repair
VCM66_0976	COG2204	response regulator
VCM66_0977	COG2198	Histidine kinase
VCM66_0978	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VCM66_0979	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VCM66_0980	COG0521	Mo-molybdopterin cofactor biosynthetic process
VCM66_0981	COG0315	cyclic pyranopterin monophosphate synthase activity
VCM66_0982	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VCM66_0983	COG0314	molybdopterin synthase activity
VCM66_0984	COG2199	diguanylate cyclase activity
VCM66_0986	COG4109	DRTGG domain
VCM66_0989	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VCM66_0991	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VCM66_0991	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VCM66_0992	COG0489	protein tyrosine kinase activity
VCM66_0993	COG0572	uridine kinase
VCM66_0994	COG2982	Protein involved in outer membrane biogenesis
VCM66_0995	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VCM66_0996	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VCM66_0998	COG2067	long-chain fatty acid transport protein
VCM66_1001	COG0183	Belongs to the thiolase family
VCM66_1002	COG1024	Enoyl-CoA hydratase
VCM66_1002	COG1250	3-hydroxyacyl-CoA dehydrogenase
VCM66_1003	COG0778	Nitroreductase
VCM66_1004	COG0583	DNA-binding transcription factor activity
VCM66_1005	COG0745	RESPONSE REGULATOR receiver
VCM66_1007	COG2832	Protein of unknown function (DUF454)
VCM66_1008	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VCM66_1010	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VCM66_1011	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VCM66_1014	COG1028	Short-chain dehydrogenase reductase Sdr
VCM66_1015	COG0616	signal peptide processing
VCM66_1017	COG1522	sequence-specific DNA binding
VCM66_1018	COG1946	Acyl-CoA thioesterase
VCM66_1022	COG3706	GGDEF domain
VCM66_1024	COG0640	Transcriptional regulator
VCM66_1025	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VCM66_1031	COG1881	PFAM PEBP family protein
VCM66_1035	COG0009	L-threonylcarbamoyladenylate synthase
VCM66_1038	COG2201	protein-glutamate methylesterase activity
VCM66_1040	COG5002	protein histidine kinase activity
VCM66_1042	COG3300	MHYT domain
VCM66_1042	COG5001	Diguanylate cyclase
VCM66_1043	COG2204	response regulator
VCM66_1048	COG0601	transmembrane transport
VCM66_1049	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VCM66_1050	COG0444	Belongs to the ABC transporter superfamily
VCM66_1051	COG4608	Belongs to the ABC transporter superfamily
VCM66_1052	COG0435	Glutathione S-transferase
VCM66_1053	COG0280	phosphate acetyltransferase
VCM66_1053	COG0857	belongs to the CobB CobQ family
VCM66_1054	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VCM66_1055	COG3092	negative regulation of chromosome organization
VCM66_1056	COG4628	conserved protein (DUF2132)
VCM66_1058	COG4120	Belongs to the binding-protein-dependent transport system permease family
VCM66_1060	COG2203	Gaf domain
VCM66_1060	COG2199	diguanylate cyclase activity
VCM66_1061	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VCM66_1063	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VCM66_1064	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VCM66_1066	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VCM66_1067	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VCM66_1068	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VCM66_1069	COG0156	8-amino-7-oxononanoate synthase activity
VCM66_1070	COG2226	methyltransferase
VCM66_1071	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VCM66_1073	COG0501	Belongs to the peptidase M48B family
VCM66_1075	COG0300	oxidoreductase activity
VCM66_1078	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VCM66_1080	COG2268	Band 7 protein
VCM66_1082	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VCM66_1083	COG2915	High frequency lysogenization protein hflD homolog
VCM66_1084	COG0482	sulfurtransferase activity
VCM66_1085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VCM66_1086	COG2916	Histone family protein nucleoid-structuring protein H-NS
VCM66_1087	COG1757	Na H antiporter
VCM66_1088	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VCM66_1089	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VCM66_1090	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VCM66_1091	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VCM66_1091	COG0131	Imidazoleglycerol-phosphate dehydratase
VCM66_1092	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VCM66_1093	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VCM66_1094	COG0107	imidazoleglycerol-phosphate synthase activity
VCM66_1095	COG0140	phosphoribosyl-ATP diphosphatase activity
VCM66_1095	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VCM66_1096	COG1187	pseudouridine synthase activity
VCM66_1098	COG1278	Cold shock
VCM66_1099	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VCM66_1100	COG0542	response to heat
VCM66_1102	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VCM66_1103	COG1454	alcohol dehydrogenase
VCM66_1103	COG1012	belongs to the aldehyde dehydrogenase family
VCM66_1104	COG1737	Transcriptional regulator
VCM66_1105	COG0076	glutamate decarboxylase activity
VCM66_1107	COG2431	L-lysine efflux transmembrane transporter activity
VCM66_1109	COG3070	regulator of competence-specific genes
VCM66_1112	COG3852	Histidine kinase
VCM66_1114	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VCM66_1117	COG4067	protein conserved in archaea
VCM66_1117	COG0189	ligase activity
VCM66_1118	COG0500	methyltransferase
VCM66_1119	COG4106	trans-aconitate 2-methyltransferase activity
VCM66_1120	COG1801	Protein of unknown function DUF72
VCM66_1121	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VCM66_1122	COG1435	thymidine kinase activity
VCM66_1124	COG0159	tryptophan synthase activity
VCM66_1125	COG0133	tryptophan synthase activity
VCM66_1126	COG0135	phosphoribosylanthranilate isomerase activity
VCM66_1126	COG0134	indole-3-glycerol-phosphate synthase activity
VCM66_1127	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VCM66_1128	COG0512	Glutamine amidotransferase of anthranilate synthase
VCM66_1129	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VCM66_1132	COG0613	PHP domain protein
VCM66_1133	COG0009	L-threonylcarbamoyladenylate synthase
VCM66_1134	COG1187	pseudouridine synthase activity
VCM66_1135	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VCM66_1136	COG4988	ABC transporter
VCM66_1137	COG0492	ferredoxin-NADP+ reductase activity
VCM66_1139	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VCM66_1140	COG3706	GGDEF domain
VCM66_1141	COG2949	membrane
VCM66_1143	COG0281	malic enzyme
VCM66_1145	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VCM66_1150	COG2885	chlorophyll binding
VCM66_1153	COG0247	lactate metabolic process
VCM66_1153	COG0277	FAD linked oxidase domain protein
VCM66_1157	COG2986	histidine ammonia-lyase
VCM66_1158	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VCM66_1159	COG0010	Belongs to the arginase family
VCM66_1160	COG1228	amidohydrolase
VCM66_1164	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VCM66_1166	COG5001	Diguanylate cyclase
VCM66_1167	COG0417	DNA replication proofreading
VCM66_1168	COG2197	response regulator
VCM66_1169	COG0322	excinuclease ABC activity
VCM66_1171	COG0745	RESPONSE REGULATOR receiver
VCM66_1171	COG3706	GGDEF domain
VCM66_1174	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VCM66_1175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VCM66_1175	COG0072	phenylalanine-tRNA ligase activity
VCM66_1177	COG0776	regulation of translation
VCM66_1181	COG0500	methyltransferase
VCM66_1186	COG0295	cytidine deaminase activity
VCM66_1187	COG1346	cytolysis
VCM66_1189	COG2925	Exonuclease
VCM66_1191	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VCM66_1192	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VCM66_1193	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VCM66_1197	COG2988	succinylglutamate desuccinylase activity
VCM66_1199	COG4139	cobalamin transport
VCM66_1200	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
VCM66_1210	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VCM66_1211	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VCM66_1212	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VCM66_1216	COG2814	Major facilitator Superfamily
VCM66_1218	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VCM66_1223	COG2989	Protein conserved in bacteria
VCM66_1224	COG3108	Peptidase M15
VCM66_1225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VCM66_1228	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VCM66_1233	COG1846	Transcriptional regulator
VCM66_1234	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VCM66_1235	COG0726	polysaccharide deacetylase
VCM66_1236	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VCM66_1238	COG1447	Phosphotransferase system cellobiose-specific component IIA
VCM66_1239	COG1486	melibiose metabolic process
VCM66_1240	COG3394	polysaccharide catabolic process
VCM66_1241	COG1609	Transcriptional regulator
VCM66_1243	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
VCM66_1244	COG0840	transmembrane signaling receptor activity
VCM66_1248	COG1448	Aminotransferase
VCM66_1250	COG2770	Histidine kinase
VCM66_1250	COG3437	response regulator, receiver
VCM66_1251	COG0351	phosphomethylpyrimidine kinase
VCM66_1252	COG0017	Asparaginyl-tRNA synthetase
VCM66_1254	COG0720	synthase
VCM66_1255	COG1760	l-serine dehydratase
VCM66_1256	COG0814	amino acid
VCM66_1257	COG0494	nUDIX hydrolase
VCM66_1258	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VCM66_1261	COG3106	COG3106 Predicted ATPase
VCM66_1262	COG3768	UPF0283 membrane protein
VCM66_1263	COG3283	Transcriptional regulator of aromatic amino acids metabolism
VCM66_1264	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VCM66_1267	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VCM66_1269	COG0471	metal ion transport
VCM66_1270	COG4191	Histidine kinase
VCM66_1270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VCM66_1272	COG2990	Protein conserved in bacteria
VCM66_1273	COG3713	MltA-interacting MipA family protein
VCM66_1274	COG2205	protein histidine kinase activity
VCM66_1275	COG0745	RESPONSE REGULATOR receiver
VCM66_1282	COG1129	ABC transporter
VCM66_1290	COG2186	Transcriptional regulator
VCM66_1291	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VCM66_1292	COG0372	Belongs to the citrate synthase family
VCM66_1298	COG2195	Cleaves the N-terminal amino acid of tripeptides
VCM66_1300	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VCM66_1302	COG0625	glutathione transferase activity
VCM66_1303	COG3437	response regulator, receiver
VCM66_1304	COG4999	Histidine kinase
VCM66_1304	COG3850	Histidine kinase
VCM66_1304	COG3437	response regulator, receiver
VCM66_1304	COG2205	protein histidine kinase activity
VCM66_1308	COG3706	GGDEF domain
VCM66_1309	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VCM66_1310	COG1254	Belongs to the acylphosphatase family
VCM66_1311	COG2920	part of a sulfur-relay system
VCM66_1313	COG0670	Belongs to the BI1 family
VCM66_1314	COG1126	abc transporter atp-binding protein
VCM66_1315	COG0765	amino acid transport
VCM66_1316	COG4597	amino acid ABC transporter
VCM66_1317	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VCM66_1319	COG0561	phosphatase activity
VCM66_1320	COG0602	queuosine metabolic process
VCM66_1321	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VCM66_1327	COG3706	GGDEF domain
VCM66_1328	COG0443	Heat shock 70 kDa protein
VCM66_1329	COG0443	Heat shock 70 kDa protein
VCM66_1337	COG1643	Atp-dependent helicase
VCM66_1341	COG0443	Heat shock 70 kDa protein
VCM66_1343	COG0095	Lipoate-protein ligase
VCM66_1345	COG0583	DNA-binding transcription factor activity
VCM66_1346	COG0477	Major facilitator Superfamily
VCM66_1347	COG0415	Belongs to the DNA photolyase family
VCM66_1348	COG2076	Multidrug Resistance protein
VCM66_1352	COG2198	Histidine kinase
VCM66_1352	COG0643	Histidine kinase
VCM66_1354	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VCM66_1356	COG2201	protein-glutamate methylesterase activity
VCM66_1357	COG0835	chemotaxis
VCM66_1358	COG0840	transmembrane signaling receptor activity
VCM66_1358	COG3290	protein histidine kinase activity
VCM66_1360	COG0840	transmembrane signaling receptor activity
VCM66_1362	COG0513	Belongs to the DEAD box helicase family
VCM66_1364	COG1538	Outer membrane efflux protein
VCM66_1365	COG1566	PFAM secretion protein HlyD family protein
VCM66_1366	COG2814	Major facilitator Superfamily
VCM66_1368	COG0840	transmembrane signaling receptor activity
VCM66_1369	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VCM66_1371	COG3501	Rhs element vgr protein
VCM66_1376	COG1280	lysine exporter protein (LysE YggA)
VCM66_1377	COG1115	amino acid carrier protein
VCM66_1380	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VCM66_1381	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VCM66_1382	COG1177	transmembrane transport
VCM66_1383	COG1176	ABC-type spermidine putrescine transport system, permease component I
VCM66_1384	COG3842	ATPase activity
VCM66_1388	COG0037	tRNA processing
VCM66_1389	COG0589	response to stress
VCM66_1390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VCM66_1393	COG2217	Heavy metal translocating P-type atpase
VCM66_1395	COG2010	Cytochrome c
VCM66_1398	COG3278	Belongs to the heme-copper respiratory oxidase family
VCM66_1401	COG0784	Response regulator, receiver
VCM66_1401	COG2205	protein histidine kinase activity
VCM66_1406	COG2994	toxin metabolic process
VCM66_1407	COG3064	Membrane
VCM66_1407	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
VCM66_1407	COG1073	alpha beta
VCM66_1424	COG3120	sequence-specific DNA binding
VCM66_1425	COG1067	ATP-dependent peptidase activity
VCM66_1426	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VCM66_1431	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VCM66_1431	COG0116	Belongs to the methyltransferase superfamily
VCM66_1434	COG0167	dihydroorotate dehydrogenase activity
VCM66_1437	COG0308	aminopeptidase N
VCM66_1440	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VCM66_1441	COG1956	GAF domain-containing protein
VCM66_1442	COG1132	(ABC) transporter
VCM66_1443	COG2995	paraquat-inducible protein a
VCM66_1444	COG3008	intermembrane lipid transfer
VCM66_1445	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VCM66_1445	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
VCM66_1446	COG2996	Protein conserved in bacteria
VCM66_1449	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VCM66_1451	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VCM66_1454	COG0437	4 iron, 4 sulfur cluster binding
VCM66_1455	COG3383	formate dehydrogenase (NAD+) activity
VCM66_1455	COG0243	molybdopterin cofactor binding
VCM66_1461	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VCM66_1462	COG0488	(ABC) transporter
VCM66_1463	COG3852	Histidine kinase
VCM66_1464	COG2204	response regulator
VCM66_1466	COG4662	Binding-protein-dependent transport system inner membrane component
VCM66_1467	COG3842	ATPase activity
VCM66_1468	COG0746	molybdenum cofactor guanylyltransferase activity
VCM66_1474	COG1940	carbohydrate kinase activity
VCM66_1477	COG0840	transmembrane signaling receptor activity
VCM66_1478	COG0791	NLP P60 protein
VCM66_1481	COG0534	Mate efflux family protein
VCM66_1483	COG1793	dna ligase
VCM66_1485	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VCM66_1486	COG0848	biopolymer transport protein
VCM66_1487	COG0811	peptide transport
VCM66_1488	COG0811	peptide transport
VCM66_1491	COG1175	transmembrane transport
VCM66_1492	COG0395	ABC-type sugar transport system, permease component
VCM66_1493	COG3842	ATPase activity
VCM66_1494	COG1349	DNA-binding transcription factor activity
VCM66_1495	COG0584	glycerophosphoryl diester phosphodiesterase
VCM66_1496	COG2731	YhcH YjgK YiaL family protein
VCM66_1497	COG0251	oxidation-reduction process
VCM66_1498	COG1609	Transcriptional regulator
VCM66_1499	COG2723	6-phospho-beta-galactosidase activity
VCM66_1501	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
VCM66_1502	COG0583	DNA-binding transcription factor activity
VCM66_1506	COG0577	efflux transmembrane transporter activity
VCM66_1506	COG1136	(ABC) transporter
VCM66_1507	COG1136	(ABC) transporter
VCM66_1507	COG0577	efflux transmembrane transporter activity
VCM66_1508	COG1136	(ABC) transporter
VCM66_1508	COG4591	ABC-type transport system involved in lipoprotein release permease component
VCM66_1510	COG1294	oxidase, subunit
VCM66_1511	COG1271	oxidase subunit
VCM66_1519	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VCM66_1521	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VCM66_1525	COG0753	catalase activity
VCM66_1529	COG3527	Alpha-acetolactate decarboxylase
VCM66_1532	COG2199	diguanylate cyclase activity
VCM66_1532	COG2200	EAL domain
VCM66_1533	COG3706	GGDEF domain
VCM66_1534	COG2017	converts alpha-aldose to the beta-anomer
VCM66_1535	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VCM66_1536	COG1085	galactose-1-phosphate uridylyltransferase
VCM66_1539	COG3706	GGDEF domain
VCM66_1539	COG0745	RESPONSE REGULATOR receiver
VCM66_1542	COG0784	Response regulator, receiver
VCM66_1542	COG0835	chemotaxis
VCM66_1544	COG4565	transcriptional regulatory protein
VCM66_1545	COG3290	protein histidine kinase activity
VCM66_1547	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCM66_1551	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
VCM66_1552	COG3063	Type IV pilus biogenesis stability protein PilW
VCM66_1555	COG1451	nucleotide metabolic process
VCM66_1557	COG0583	DNA-binding transcription factor activity
VCM66_1561	COG1538	Outer membrane efflux protein
VCM66_1563	COG0019	diaminopimelate decarboxylase activity
VCM66_1564	COG1748	Saccharopine dehydrogenase
VCM66_1566	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VCM66_1569	COG4181	ATPase activity
VCM66_1570	COG0534	Mate efflux family protein
VCM66_1571	COG0702	epimerase
VCM66_1573	COG2814	Major facilitator Superfamily
VCM66_1574	COG1187	pseudouridine synthase activity
VCM66_1575	COG1061	Type III restriction enzyme res subunit
VCM66_1579	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VCM66_1580	COG4251	negative regulation of phosphorylation
VCM66_1580	COG2203	Gaf domain
VCM66_1580	COG5001	Diguanylate cyclase
VCM66_1580	COG3706	GGDEF domain
VCM66_1582	COG0840	transmembrane signaling receptor activity
VCM66_1589	COG4934	collagen metabolic process
VCM66_1594	COG2239	Acts as a magnesium transporter
VCM66_1597	COG0814	amino acid
VCM66_1598	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCM66_1599	COG1131	(ABC) transporter
VCM66_1600	COG0842	Transport permease protein
VCM66_1602	COG3313	Fe-S protein
VCM66_1604	COG4134	Bacterial extracellular solute-binding protein
VCM66_1605	COG4135	transport system, permease component
VCM66_1606	COG4136	ATPase activity
VCM66_1607	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VCM66_1608	COG0564	pseudouridine synthase activity
VCM66_1609	COG0733	neurotransmitter:sodium symporter activity
VCM66_1611	COG0626	cystathionine gamma-synthase activity
VCM66_1612	COG2818	Glycosylase
VCM66_1615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCM66_1618	COG1842	Phage shock protein A
VCM66_1619	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VCM66_1621	COG4168	peptide transport system, permease
VCM66_1622	COG4171	peptide transport system, permease
VCM66_1624	COG4172	Belongs to the ABC transporter superfamily
VCM66_1627	COG1227	inorganic diphosphatase activity
VCM66_1632	COG0243	molybdopterin cofactor binding
VCM66_1633	COG3005	denitrification pathway
VCM66_1634	COG4459	periplasmic nitrate reductase
VCM66_1635	COG2116	formate transmembrane transporter activity
VCM66_1637	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VCM66_1638	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VCM66_1640	COG2917	probably involved in intracellular septation
VCM66_1641	COG1607	acyl-coa hydrolase
VCM66_1642	COG2350	Protein conserved in bacteria
VCM66_1644	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VCM66_1646	COG0583	DNA-binding transcription factor activity
VCM66_1649	COG0612	Peptidase, M16
VCM66_1651	COG1032	radical SAM domain protein
VCM66_1654	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VCM66_1655	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VCM66_1656	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
VCM66_1657	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VCM66_1658	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VCM66_1659	COG0745	RESPONSE REGULATOR receiver
VCM66_1661	COG1609	Transcriptional regulator
VCM66_1662	COG3070	regulator of competence-specific genes
VCM66_1666	COG0297	glycogen (starch) synthase activity
VCM66_1667	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VCM66_1670	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VCM66_1672	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VCM66_1675	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VCM66_1676	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VCM66_1677	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VCM66_1678	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VCM66_1684	COG1012	belongs to the aldehyde dehydrogenase family
VCM66_1685	COG1309	transcriptional regulator
VCM66_1690	COG0668	transmembrane transport
VCM66_1692	COG2995	paraquat-inducible protein a
VCM66_1693	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VCM66_1693	COG3008	intermembrane lipid transfer
VCM66_1695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCM66_1697	COG0582	viral genome integration into host DNA
VCM66_1699	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VCM66_1703	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VCM66_1707	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VCM66_1711	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
VCM66_1712	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
VCM66_1713	COG1737	Transcriptional regulator
VCM66_1714	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VCM66_1715	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VCM66_1716	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VCM66_1717	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VCM66_1719	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
VCM66_1720	COG1940	carbohydrate kinase activity
VCM66_1721	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VCM66_1722	COG4409	exo-alpha-(2->6)-sialidase activity
VCM66_1724	COG2003	Belongs to the UPF0758 family
VCM66_1737	COG0415	Belongs to the DNA photolyase family
VCM66_1739	COG4628	conserved protein (DUF2132)
VCM66_1740	COG3284	Transcriptional regulator
VCM66_1742	COG1012	belongs to the aldehyde dehydrogenase family
VCM66_1744	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCM66_1745	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCM66_1746	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCM66_1748	COG2207	Transcriptional regulator
VCM66_1749	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCM66_1749	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCM66_1749	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCM66_1750	COG1482	cell wall glycoprotein biosynthetic process
VCM66_1754	COG0784	Response regulator, receiver
VCM66_1754	COG5002	protein histidine kinase activity
VCM66_1756	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VCM66_1758	COG2885	chlorophyll binding
VCM66_1759	COG0823	Involved in the tonB-independent uptake of proteins
VCM66_1762	COG0811	peptide transport
VCM66_1763	COG0824	Thioesterase
VCM66_1764	COG3790	cyd operon protein YbgE
VCM66_1765	COG4890	Cyd operon protein YbgT
VCM66_1766	COG1294	oxidase, subunit
VCM66_1767	COG1271	oxidase subunit
VCM66_1768	COG2255	four-way junction helicase activity
VCM66_1769	COG0632	four-way junction helicase activity
VCM66_1770	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VCM66_1771	COG0215	cysteine-tRNA ligase activity
VCM66_1772	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VCM66_1773	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VCM66_1774	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VCM66_1776	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VCM66_1777	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VCM66_1778	COG1199	ATP-dependent helicase activity
VCM66_1779	COG0730	response to heat
VCM66_1780	COG3923	Primosomal replication protein n
VCM66_1782	COG0840	transmembrane signaling receptor activity
VCM66_1783	COG0708	Exodeoxyribonuclease III
VCM66_1784	COG4160	amino acid transport
VCM66_1785	COG4215	(ABC) transporter
VCM66_1789	COG1882	Formate acetyltransferase
VCM66_1791	COG0840	transmembrane signaling receptor activity
VCM66_1792	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VCM66_1794	COG3013	Belongs to the UPF0304 family
VCM66_1795	COG2766	serine protein kinase
VCM66_1796	COG2718	Belongs to the UPF0229 family
VCM66_1797	COG2719	SpoVR family
VCM66_1798	COG1943	Transposase
VCM66_1799	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VCM66_1801	COG1663	tetraacyldisaccharide 4'-kinase activity
VCM66_1802	COG1132	(ABC) transporter
VCM66_1803	COG0658	competence protein
VCM66_1803	COG2333	competence protein COMEC
VCM66_1806	COG4591	ABC-type transport system involved in lipoprotein release permease component
VCM66_1807	COG1136	(ABC) transporter
VCM66_1808	COG4591	ABC-type transport system involved in lipoprotein release permease component
VCM66_1810	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VCM66_1814	COG1252	NADH dehydrogenase
VCM66_1821	COG0537	adenosine 5'-monophosphoramidase activity
VCM66_1824	COG2186	Transcriptional regulator
VCM66_1825	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VCM66_1826	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VCM66_1827	COG1674	ftsk spoiiie
VCM66_1829	COG0686	Belongs to the AlaDH PNT family
VCM66_1831	COG0583	DNA-binding transcription factor activity
VCM66_1835	COG0284	orotidine-5'-phosphate decarboxylase activity
VCM66_1836	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VCM66_1837	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VCM66_1838	COG0776	regulation of translation
VCM66_1839	COG0539	negative regulation of cytoplasmic translation
VCM66_1840	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VCM66_1841	COG1555	photosystem II stabilization
VCM66_1842	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VCM66_1843	COG0776	regulation of translation
VCM66_1844	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VCM66_1845	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VCM66_1846	COG0740	serine-type endopeptidase activity
VCM66_1847	COG0544	peptidyl-prolyl cis-trans isomerase activity
VCM66_1849	COG4191	Histidine kinase
VCM66_1851	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VCM66_1852	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VCM66_1853	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VCM66_1855	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VCM66_1858	COG3300	MHYT domain
VCM66_1858	COG5001	Diguanylate cyclase
VCM66_1860	COG4589	Belongs to the CDS family
VCM66_1866	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VCM66_1869	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VCM66_1874	COG0243	molybdopterin cofactor binding
VCM66_1875	COG3005	denitrification pathway
VCM66_1876	COG3469	chitinase activity
VCM66_1876	COG3325	Belongs to the glycosyl hydrolase 18 family
VCM66_1877	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VCM66_1880	COG2951	lytic endotransglycosylase activity
VCM66_1881	COG3100	YcgL domain-containing protein
VCM66_1883	COG0850	regulation of cytokinetic process
VCM66_1884	COG2894	cell division
VCM66_1885	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VCM66_1886	COG3015	lipoprotein NlpE involved in copper resistance
VCM66_1890	COG0477	Major facilitator Superfamily
VCM66_1891	COG0840	transmembrane signaling receptor activity
VCM66_1892	COG1396	sequence-specific DNA binding
VCM66_1894	COG3135	benzoate transporter
VCM66_1896	COG1441	menaquinone biosynthetic process
VCM66_1898	COG0596	Alpha beta hydrolase
VCM66_1899	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VCM66_1900	COG1169	isochorismate synthase
VCM66_1901	COG0436	Aminotransferase
VCM66_1902	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VCM66_1903	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VCM66_1908	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VCM66_1909	COG0318	PFAM AMP-dependent synthetase and ligase
VCM66_1910	COG0596	Alpha beta hydrolase
VCM66_1913	COG1214	PFAM Peptidase M22, glycoprotease
VCM66_1914	COG1199	ATP-dependent helicase activity
VCM66_1916	COG0788	formyltetrahydrofolate deformylase activity
VCM66_1917	COG1902	pentaerythritol trinitrate reductase activity
VCM66_1917	COG0446	pyridine nucleotide-disulphide oxidoreductase
VCM66_1918	COG0616	signal peptide processing
VCM66_1919	COG0252	asparaginase activity
VCM66_1920	COG3139	Protein of unknown function (DUF1315)
VCM66_1922	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VCM66_1924	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VCM66_1925	COG0676	glucose-6-phosphate 1-epimerase activity
VCM66_1927	COG2226	methyltransferase
VCM66_1930	COG0784	Response regulator, receiver
VCM66_1930	COG0835	chemotaxis
VCM66_1931	COG1940	carbohydrate kinase activity
VCM66_1933	COG4667	esterase of the alpha-beta hydrolase superfamily
VCM66_1936	COG0733	neurotransmitter:sodium symporter activity
VCM66_1937	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VCM66_1937	COG1263	PTS System
VCM66_1938	COG0084	hydrolase, TatD family'
VCM66_1940	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VCM66_1941	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VCM66_1942	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VCM66_1943	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VCM66_1944	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VCM66_1945	COG1028	Short-chain dehydrogenase reductase Sdr
VCM66_1946	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
VCM66_1947	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VCM66_1948	COG0416	fatty acid biosynthetic process
VCM66_1949	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VCM66_1950	COG1399	metal-binding, possibly nucleic acid-binding protein
VCM66_1951	COG0424	maF-like protein
VCM66_1952	COG0564	pseudouridine synthase activity
VCM66_1954	COG1530	ribonuclease E activity
VCM66_1955	COG0659	secondary active sulfate transmembrane transporter activity
VCM66_1957	COG1454	alcohol dehydrogenase
VCM66_1957	COG1012	belongs to the aldehyde dehydrogenase family
VCM66_1959	COG2095	MarC family integral membrane protein
VCM66_1960	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VCM66_1961	COG1757	Na H antiporter
VCM66_1963	COG3081	Nucleoid-associated protein
VCM66_1965	COG3083	sulfuric ester hydrolase activity
VCM66_1966	COG0123	including yeast histone deacetylase and acetoin utilization protein
VCM66_1967	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VCM66_1968	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VCM66_1972	COG2853	Lipoprotein
VCM66_1974	COG3088	subunit of a heme lyase
VCM66_1974	COG4235	cytochrome complex assembly
VCM66_1975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VCM66_1976	COG1138	Cytochrome C-type biogenesis protein
VCM66_1977	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VCM66_1979	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VCM66_1980	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VCM66_1981	COG4133	protoheme IX ABC transporter activity
VCM66_1983	COG0835	chemotaxis
VCM66_1985	COG1192	Involved in chromosome partitioning
VCM66_1986	COG2201	protein-glutamate methylesterase activity
VCM66_1987	COG0643	Histidine kinase
VCM66_1987	COG2198	Histidine kinase
VCM66_1988	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VCM66_1991	COG0455	bacterial-type flagellum organization
VCM66_1996	COG1025	Belongs to the peptidase M16 family
VCM66_1998	COG0018	arginyl-trna synthetase
VCM66_2002	COG1918	ferrous iron import across plasma membrane
VCM66_2004	COG4977	sequence-specific DNA binding
VCM66_2005	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VCM66_2006	COG1121	(ABC) transporter
VCM66_2007	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VCM66_2009	COG0045	succinate-CoA ligase (ADP-forming) activity
VCM66_2010	COG0508	dehydrogenase complex catalyzes the overall conversion of
VCM66_2011	COG0567	Dehydrogenase, E1 component
VCM66_2013	COG1053	succinate dehydrogenase
VCM66_2014	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VCM66_2015	COG2009	succinate dehydrogenase
VCM66_2016	COG0372	Belongs to the citrate synthase family
VCM66_2017	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VCM66_2019	COG0033	Phosphoglucomutase
VCM66_2020	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VCM66_2021	COG0596	Alpha beta hydrolase
VCM66_2024	COG1346	cytolysis
VCM66_2027	COG0583	DNA-binding transcription factor activity
VCM66_2029	COG0735	belongs to the Fur family
VCM66_2030	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VCM66_2031	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VCM66_2032	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VCM66_2033	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VCM66_2033	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VCM66_2034	COG0431	NADPH-dependent FMN reductase
VCM66_2036	COG3101	peptidyl-lysine hydroxylation
VCM66_2038	COG2860	membrane
VCM66_2039	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VCM66_2041	COG2890	protein-(glutamine-N5) methyltransferase activity
VCM66_2044	COG1684	flagellar biosynthetic protein fliR
VCM66_2045	COG1987	bacterial-type flagellum assembly
VCM66_2050	COG1580	Controls the rotational direction of flagella during chemotaxis
VCM66_2054	COG1317	bacterial-type flagellum organization
VCM66_2055	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VCM66_2057	COG1677	Flagellar hook-basal body complex protein FliE
VCM66_2058	COG2204	response regulator
VCM66_2059	COG4191	Histidine kinase
VCM66_2060	COG2204	response regulator
VCM66_2061	COG1516	flagellar protein fliS
VCM66_2063	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VCM66_2064	COG1334	flagellar protein FlaG
VCM66_2065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VCM66_2066	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VCM66_2067	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VCM66_2068	COG2837	iron assimilation
VCM66_2073	COG1393	Belongs to the ArsC family
VCM66_2075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VCM66_2076	COG1876	peptidase activity
VCM66_2079	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VCM66_2080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VCM66_2083	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VCM66_2087	COG4783	chaperone-mediated protein folding
VCM66_2088	COG1393	Belongs to the ArsC family
VCM66_2094	COG2233	PERMEase
VCM66_2095	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VCM66_2097	COG0737	Belongs to the 5'-nucleotidase family
VCM66_2098	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VCM66_2099	COG2912	Transglutaminase-like superfamily
VCM66_2100	COG3094	Invasion gene expression up-regulator, SirB
VCM66_2101	COG2890	protein-(glutamine-N5) methyltransferase activity
VCM66_2102	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VCM66_2103	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VCM66_2104	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
VCM66_2105	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VCM66_2106	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VCM66_2107	COG0193	aminoacyl-tRNA hydrolase activity
VCM66_2108	COG0012	GTP binding
VCM66_2110	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VCM66_2111	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VCM66_2115	COG3951	Flagellar rod assembly protein muramidase FlgJ
VCM66_2115	COG1705	Flagellar rod assembly protein muramidase FlgJ
VCM66_2116	COG1706	bacterial-type flagellum-dependent cell motility
VCM66_2117	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VCM66_2118	COG4786	Flagellar basal body rod
VCM66_2119	COG4787	bacterial-type flagellum-dependent cell motility
VCM66_2120	COG1749	Flagellar hook protein flgE
VCM66_2121	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
VCM66_2122	COG1558	bacterial-type flagellum-dependent cell motility
VCM66_2123	COG1815	bacterial-type flagellum-dependent cell motility
VCM66_2124	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VCM66_2125	COG0784	Response regulator, receiver
VCM66_2125	COG0835	chemotaxis
VCM66_2132	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VCM66_2132	COG2226	methyltransferase
VCM66_2132	COG3433	isochorismatase activity
VCM66_2133	COG2375	cellular response to nickel ion
VCM66_2134	COG4774	siderophore transport
VCM66_2134	COG1629	transport
VCM66_2137	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VCM66_2138	COG2608	mercury ion transmembrane transporter activity
VCM66_2138	COG2217	Heavy metal translocating P-type atpase
VCM66_2143	COG3735	TraB family
VCM66_2145	COG2840	Smr protein MutS2
VCM66_2146	COG1187	pseudouridine synthase activity
VCM66_2147	COG3706	GGDEF domain
VCM66_2148	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VCM66_2149	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VCM66_2150	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VCM66_2152	COG0121	glutamine amidotransferase
VCM66_2153	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VCM66_2154	COG1960	acyl-CoA dehydrogenase activity
VCM66_2156	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VCM66_2157	COG0328	RNA-DNA hybrid ribonuclease activity
VCM66_2158	COG2226	methyltransferase
VCM66_2159	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VCM66_2160	COG0741	lytic transglycosylase activity
VCM66_2160	COG1388	LysM domain
VCM66_2162	COG0347	Belongs to the P(II) protein family
VCM66_2163	COG3479	Phenolic acid decarboxylase
VCM66_2165	COG0037	tRNA processing
VCM66_2167	COG0825	malonyl-CoA metabolic process
VCM66_2168	COG0587	DNA-directed DNA polymerase activity
VCM66_2169	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VCM66_2170	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VCM66_2171	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VCM66_2172	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VCM66_2173	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VCM66_2174	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VCM66_2176	COG0750	zinc metalloprotease
VCM66_2177	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VCM66_2178	COG0575	Belongs to the CDS family
VCM66_2179	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VCM66_2180	COG0233	cytoplasmic translational termination
VCM66_2181	COG0528	UMP kinase activity
VCM66_2182	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VCM66_2183	COG0052	Belongs to the universal ribosomal protein uS2 family
VCM66_2184	COG0024	Methionine aminopeptidase
VCM66_2185	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VCM66_2188	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VCM66_2189	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VCM66_2190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VCM66_2191	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VCM66_2194	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VCM66_2194	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VCM66_2195	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VCM66_2196	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VCM66_2197	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VCM66_2200	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VCM66_2201	COG2252	PERMEase
VCM66_2202	COG2195	Cleaves the N-terminal amino acid of tripeptides
VCM66_2203	COG4067	protein conserved in archaea
VCM66_2203	COG0189	ligase activity
VCM66_2204	COG0189	ligase activity
VCM66_2206	COG0733	neurotransmitter:sodium symporter activity
VCM66_2208	COG3706	GGDEF domain
VCM66_2210	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VCM66_2212	COG1477	protein flavinylation
VCM66_2213	COG2871	sodium ion transport
VCM66_2214	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VCM66_2215	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VCM66_2216	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VCM66_2217	COG1805	sodium ion transport
VCM66_2218	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VCM66_2219	COG0271	Belongs to the BolA IbaG family
VCM66_2220	COG2813	Specifically methylates the guanine in position
VCM66_2222	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VCM66_2223	COG2211	Major facilitator Superfamily
VCM66_2225	COG1595	DNA-templated transcription, initiation
VCM66_2228	COG3248	Nucleoside-binding outer membrane protein
VCM66_2230	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VCM66_2231	COG0693	protein deglycase activity
VCM66_2232	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VCM66_2233	COG2166	iron-sulfur cluster assembly
VCM66_2234	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VCM66_2235	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VCM66_2239	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VCM66_2239	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VCM66_2242	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VCM66_2243	COG1074	ATP-dependent DNA helicase activity
VCM66_2245	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VCM66_2249	COG3141	response to X-ray
VCM66_2252	COG2171	N-acyltransferase activity
VCM66_2255	COG0456	acetyltransferase
VCM66_2256	COG0569	domain protein
VCM66_2256	COG0189	ligase activity
VCM66_2259	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VCM66_2260	COG1609	Transcriptional regulator
VCM66_2261	COG3250	beta-galactosidase activity
VCM66_2264	COG1022	Amp-dependent synthetase and ligase
VCM66_2265	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VCM66_2266	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VCM66_2268	COG0560	Phosphoserine phosphatase
VCM66_2270	COG0813	purine-nucleoside phosphorylase activity
VCM66_2271	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VCM66_2272	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VCM66_2273	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VCM66_2275	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VCM66_2276	COG0084	hydrolase, TatD family'
VCM66_2279	COG1115	amino acid carrier protein
VCM66_2282	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VCM66_2283	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VCM66_2284	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VCM66_2285	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VCM66_2286	COG0083	homoserine kinase activity
VCM66_2289	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VCM66_2291	COG0745	RESPONSE REGULATOR receiver
VCM66_2292	COG5002	protein histidine kinase activity
VCM66_2292	COG2198	Histidine kinase
VCM66_2292	COG0784	Response regulator, receiver
VCM66_2293	COG2203	Gaf domain
VCM66_2293	COG3706	GGDEF domain
VCM66_2293	COG4251	negative regulation of phosphorylation
VCM66_2293	COG5001	Diguanylate cyclase
VCM66_2294	COG1242	4 iron, 4 sulfur cluster binding
VCM66_2296	COG0067	glutamate synthase
VCM66_2296	COG0069	glutamate synthase activity
VCM66_2296	COG0070	glutamate synthase
VCM66_2299	COG0070	glutamate synthase
VCM66_2299	COG0069	glutamate synthase activity
VCM66_2299	COG0067	glutamate synthase
VCM66_2300	COG0493	'glutamate synthase
VCM66_2302	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VCM66_2304	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VCM66_2305	COG2860	membrane
VCM66_2306	COG0583	DNA-binding transcription factor activity
VCM66_2307	COG0730	response to heat
VCM66_2312	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VCM66_2313	COG0505	Belongs to the CarA family
VCM66_2314	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VCM66_2315	COG0494	nUDIX hydrolase
VCM66_2317	COG0653	protein targeting
VCM66_2319	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VCM66_2320	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VCM66_2321	COG0849	cell division
VCM66_2322	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VCM66_2323	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VCM66_2324	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VCM66_2325	COG0772	Belongs to the SEDS family
VCM66_2326	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VCM66_2327	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VCM66_2328	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VCM66_2329	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VCM66_2330	COG0768	penicillin binding
VCM66_2331	COG3116	cell division
VCM66_2332	COG0275	rRNA processing
VCM66_2335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VCM66_2336	COG0508	dehydrogenase complex catalyzes the overall conversion of
VCM66_2337	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VCM66_2338	COG2186	Transcriptional regulator
VCM66_2339	COG0737	Belongs to the 5'-nucleotidase family
VCM66_2340	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VCM66_2341	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VCM66_2342	COG4974	Belongs to the 'phage' integrase family
VCM66_2343	COG0716	FMN binding
VCM66_2347	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VCM66_2348	COG1459	type II secretion system
VCM66_2350	COG0237	dephospho-CoA kinase activity
VCM66_2351	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VCM66_2352	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VCM66_2353	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VCM66_2354	COG0187	DNA topoisomerase II activity
VCM66_2355	COG3150	esterase
VCM66_2357	COG3151	Protein conserved in bacteria
VCM66_2358	COG0494	nUDIX hydrolase
VCM66_2359	COG1538	Outer membrane efflux protein
VCM66_2361	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VCM66_2362	COG0840	transmembrane signaling receptor activity
VCM66_2363	COG3025	triphosphatase activity
VCM66_2364	COG1392	Phosphate transport regulator
VCM66_2365	COG0306	phosphate transporter
VCM66_2366	COG4991	sh3 domain protein
VCM66_2368	COG3267	Type II secretory pathway component ExeA
VCM66_2368	COG3409	Peptidoglycan-binding domain 1 protein
VCM66_2369	COG0617	tRNA 3'-terminal CCA addition
VCM66_2370	COG0148	phosphopyruvate hydratase activity
VCM66_2371	COG0504	CTP synthase activity
VCM66_2373	COG3956	TIGRFAM MazG family protein
VCM66_2374	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VCM66_2375	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VCM66_2377	COG5001	Diguanylate cyclase
VCM66_2380	COG0736	holo-[acyl-carrier-protein] synthase activity
VCM66_2381	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VCM66_2382	COG1381	Involved in DNA repair and RecF pathway recombination
VCM66_2383	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VCM66_2384	COG0571	ribonuclease III activity
VCM66_2385	COG0681	Belongs to the peptidase S26 family
VCM66_2386	COG0481	GTPase activity
VCM66_2387	COG3086	response to oxidative stress
VCM66_2388	COG3026	antisigma factor binding
VCM66_2390	COG1595	DNA-templated transcription, initiation
VCM66_2392	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VCM66_2394	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VCM66_2395	COG0354	folic acid binding
VCM66_2397	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VCM66_2398	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VCM66_2400	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VCM66_2401	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VCM66_2402	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VCM66_2403	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VCM66_2404	COG0440	acetolactate synthase activity
VCM66_2405	COG0028	Belongs to the TPP enzyme family
VCM66_2406	COG1022	Amp-dependent synthetase and ligase
VCM66_2407	COG0583	DNA-binding transcription factor activity
VCM66_2412	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VCM66_2413	COG0473	3-isopropylmalate dehydrogenase activity
VCM66_2414	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VCM66_2415	COG0066	3-isopropylmalate dehydratase activity
VCM66_2419	COG3437	response regulator, receiver
VCM66_2421	COG0795	lipopolysaccharide-transporting ATPase activity
VCM66_2422	COG0795	lipopolysaccharide-transporting ATPase activity
VCM66_2423	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VCM66_2424	COG2927	DNA polymerase III (CHI subunit)
VCM66_2425	COG0525	valine-tRNA ligase activity
VCM66_2426	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VCM66_2427	COG0564	pseudouridine synthase activity
VCM66_2428	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VCM66_2429	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VCM66_2430	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VCM66_2432	COG0540	Belongs to the ATCase OTCase family
VCM66_2433	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VCM66_2434	COG0251	oxidation-reduction process
VCM66_2435	COG0204	Acyl-transferase
VCM66_2436	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VCM66_2437	COG5007	Belongs to the BolA IbaG family
VCM66_2439	COG2854	intermembrane phospholipid transfer
VCM66_2440	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VCM66_2441	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VCM66_2442	COG1127	ABC transporter
VCM66_2445	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VCM66_2445	COG0517	IMP dehydrogenase activity
VCM66_2448	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VCM66_2449	COG1137	ATPase activity
VCM66_2451	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VCM66_2452	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCM66_2454	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCM66_2455	COG2239	Acts as a magnesium transporter
VCM66_2456	COG0312	modulator of DNA gyrase
VCM66_2457	COG3028	Belongs to the UPF0307 family
VCM66_2458	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VCM66_2459	COG1178	ABC-type Fe3 transport system permease component
VCM66_2460	COG4143	(ABC) transporter
VCM66_2462	COG0163	prenyltransferase activity
VCM66_2463	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VCM66_2465	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VCM66_2466	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VCM66_2467	COG2105	PFAM AIG2 family protein
VCM66_2469	COG0729	surface antigen
VCM66_2470	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VCM66_2471	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VCM66_2474	COG1136	(ABC) transporter
VCM66_2478	COG0529	Catalyzes the synthesis of activated sulfate
VCM66_2479	COG2895	sulfate adenylyltransferase (ATP) activity
VCM66_2480	COG0175	sulfate reduction
VCM66_2481	COG1648	precorrin-2 dehydrogenase activity
VCM66_2481	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VCM66_2482	COG0737	Belongs to the 5'-nucleotidase family
VCM66_2484	COG0513	Belongs to the DEAD box helicase family
VCM66_2485	COG2153	protein acetylation
VCM66_2486	COG0697	spore germination
VCM66_2487	COG3266	domain, Protein
VCM66_2487	COG3061	Opacity-associated protein A
VCM66_2488	COG0545	Peptidyl-prolyl cis-trans isomerase
VCM66_2490	COG0203	ribosomal protein L17
VCM66_2491	COG0202	RNA polymerase activity
VCM66_2492	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VCM66_2493	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VCM66_2494	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VCM66_2496	COG0201	protein transport
VCM66_2497	COG0200	Binds to the 23S rRNA
VCM66_2498	COG1841	ribosomal large subunit assembly
VCM66_2499	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VCM66_2500	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VCM66_2501	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VCM66_2502	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VCM66_2503	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VCM66_2504	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VCM66_2505	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VCM66_2506	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VCM66_2507	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VCM66_2508	COG0255	Belongs to the universal ribosomal protein uL29 family
VCM66_2509	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VCM66_2510	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VCM66_2511	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VCM66_2512	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VCM66_2513	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VCM66_2514	COG0089	rRNA binding
VCM66_2515	COG0088	Forms part of the polypeptide exit tunnel
VCM66_2516	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VCM66_2517	COG0051	transcription antitermination factor activity, RNA binding
VCM66_2518	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VCM66_2519	COG0557	exoribonuclease II activity
VCM66_2520	COG3083	sulfuric ester hydrolase activity
VCM66_2521	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VCM66_2522	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VCM66_2524	COG1047	Peptidyl-prolyl cis-trans
VCM66_2527	COG2249	NAD(P)H dehydrogenase (quinone) activity
VCM66_2528	COG0488	(ABC) transporter
VCM66_2530	COG0429	hydrolase of the alpha beta-hydrolase fold
VCM66_2533	COG3954	Phosphoribulokinase
VCM66_2534	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VCM66_2538	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VCM66_2540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VCM66_2543	COG0180	Tryptophanyl-tRNA synthetase
VCM66_2544	COG0546	phosphoglycolate phosphatase activity
VCM66_2545	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VCM66_2546	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VCM66_2548	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VCM66_2549	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VCM66_2555	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VCM66_2557	COG0678	peroxiredoxin activity
VCM66_2557	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VCM66_2558	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VCM66_2561	COG0165	Argininosuccinate lyase
VCM66_2562	COG0137	argininosuccinate synthase activity
VCM66_2563	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VCM66_2564	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VCM66_2565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VCM66_2566	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VCM66_2569	COG1045	serine acetyltransferase
VCM66_2571	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VCM66_2573	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VCM66_2574	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VCM66_2575	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VCM66_2576	COG1053	succinate dehydrogenase
VCM66_2577	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VCM66_2578	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VCM66_2579	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VCM66_2580	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VCM66_2581	COG1509	lysine 2,3-aminomutase activity
VCM66_2584	COG0459	protein refolding
VCM66_2585	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VCM66_2590	COG0149	triose-phosphate isomerase activity
VCM66_2592	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VCM66_2593	COG1575	Belongs to the MenA family. Type 1 subfamily
VCM66_2595	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VCM66_2596	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VCM66_2597	COG1609	Transcriptional regulator
VCM66_2598	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VCM66_2599	COG0254	rRNA binding
VCM66_2601	COG0281	malic enzyme
VCM66_2602	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
VCM66_2603	COG0626	cystathionine gamma-synthase activity
VCM66_2604	COG0527	aspartate kinase activity
VCM66_2604	COG0460	homoserine dehydrogenase
VCM66_2605	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VCM66_2606	COG3074	FtsZ-dependent cytokinesis
VCM66_2608	COG1494	fructose-1,6-bisphosphatase
VCM66_2609	COG0205	6-phosphofructokinase activity
VCM66_2610	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VCM66_2612	COG0745	RESPONSE REGULATOR receiver
VCM66_2613	COG2205	protein histidine kinase activity
VCM66_2615	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VCM66_2616	COG3030	protein affecting phage T7 exclusion by the F plasmid
VCM66_2617	COG3706	GGDEF domain
VCM66_2618	COG1027	Aspartate ammonia-lyase
VCM66_2619	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VCM66_2621	COG4232	protein-disulfide reductase activity
VCM66_2623	COG3263	regulation of cellular component size
VCM66_2625	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VCM66_2626	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VCM66_2628	COG0194	GDP metabolic process
VCM66_2629	COG1758	RNA polymerase activity
VCM66_2630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VCM66_2631	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VCM66_2632	COG2233	PERMEase
VCM66_2634	COG0745	RESPONSE REGULATOR receiver
VCM66_2635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VCM66_2636	COG2183	response to ionizing radiation
VCM66_2638	COG0596	Alpha beta hydrolase
VCM66_2639	COG1040	competence protein
VCM66_2640	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VCM66_2640	COG0316	Belongs to the HesB IscA family
VCM66_2641	COG0494	nUDIX hydrolase
VCM66_2642	COG1218	3'(2'),5'-bisphosphate nucleotidase
VCM66_2644	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VCM66_2645	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VCM66_2646	COG3156	type II secretion system protein K
VCM66_2647	COG4795	General secretion pathway protein
VCM66_2648	COG2165	general secretion pathway protein
VCM66_2649	COG2165	general secretion pathway protein
VCM66_2650	COG2165	general secretion pathway protein
VCM66_2651	COG1459	type II secretion system
VCM66_2652	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VCM66_2654	COG3031	protein transport across the cell outer membrane
VCM66_2655	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VCM66_2656	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VCM66_2658	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VCM66_2660	COG0456	acetyltransferase
VCM66_2661	COG1490	D-aminoacyl-tRNA deacylase activity
VCM66_2663	COG1660	Displays ATPase and GTPase activities
VCM66_2666	COG0174	glutamine synthetase
VCM66_2668	COG3852	Histidine kinase
VCM66_2670	COG5001	Diguanylate cyclase
VCM66_2670	COG3300	MHYT domain
VCM66_2671	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VCM66_2675	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
VCM66_2676	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VCM66_2677	COG1739	Uncharacterized protein family UPF0029
VCM66_2678	COG1250	3-hydroxyacyl-CoA dehydrogenase
VCM66_2678	COG1024	Enoyl-CoA hydratase
VCM66_2679	COG0183	Belongs to the thiolase family
VCM66_2680	COG0583	DNA-binding transcription factor activity
VCM66_2681	COG2814	Major facilitator Superfamily
VCM66_2683	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VCM66_2684	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VCM66_2685	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VCM66_2686	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VCM66_2687	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VCM66_2688	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VCM66_2690	COG0356	it plays a direct role in the translocation of protons across the membrane
VCM66_2691	COG3312	ion transport
VCM66_2692	COG1475	DNA binding
VCM66_2693	COG1192	Involved in chromosome partitioning
VCM66_2694	COG0357	Ribosomal RNA small subunit methyltransferase G
VCM66_2695	COG0445	tRNA wobble uridine modification
VCM66_A0006	COG0217	transcriptional regulatory protein
VCM66_A0007	COG2084	Dehydrogenase
VCM66_A0011	COG2909	trisaccharide binding
VCM66_A0013	COG0058	SHG alpha-glucan phosphorylase activity
VCM66_A0014	COG1640	4-alpha-glucanotransferase
VCM66_A0015	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VCM66_A0017	COG3501	Rhs element vgr protein
VCM66_A0024	COG0471	metal ion transport
VCM66_A0025	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VCM66_A0034	COG0671	phosphoesterase, PA-phosphatase related
VCM66_A0035	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
VCM66_A0037	COG1999	signal sequence binding
VCM66_A0040	COG0786	glutamate:sodium symporter activity
VCM66_A0045	COG1566	PFAM secretion protein HlyD family protein
VCM66_A0047	COG3706	GGDEF domain
VCM66_A0050	COG0813	purine-nucleoside phosphorylase activity
VCM66_A0052	COG3272	Protein of unknown function (DUF1722)
VCM66_A0054	COG0415	Belongs to the DNA photolyase family
VCM66_A0055	COG1376	ErfK ybiS ycfS ynhG family protein
VCM66_A0055	COG1388	LysM domain
VCM66_A0058	COG0513	Belongs to the DEAD box helicase family
VCM66_A0060	COG1770	oligopeptidase
VCM66_A0067	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VCM66_A0068	COG0573	inorganic phosphate transmembrane transporter activity
VCM66_A0069	COG0581	inorganic phosphate transmembrane transporter activity
VCM66_A0070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VCM66_A0075	COG0659	secondary active sulfate transmembrane transporter activity
VCM66_A0077	COG0739	heme binding
VCM66_A0078	COG3300	MHYT domain
VCM66_A0078	COG5001	Diguanylate cyclase
VCM66_A0080	COG0583	DNA-binding transcription factor activity
VCM66_A0081	COG2814	Major facilitator Superfamily
VCM66_A0086	COG1301	dicarboxylic acid transport
VCM66_A0089	COG1342	Belongs to the UPF0251 family
VCM66_A0096	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
VCM66_A0097	COG0673	inositol 2-dehydrogenase activity
VCM66_A0099	COG2771	luxR family
VCM66_A0099	COG2200	EAL domain
VCM66_A0100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VCM66_A0102	COG0564	pseudouridine synthase activity
VCM66_A0121	COG3501	Rhs element vgr protein
VCM66_A0125	COG1869	D-ribose catabolic process
VCM66_A0126	COG1129	ABC transporter
VCM66_A0127	COG1172	Belongs to the binding-protein-dependent transport system permease family
VCM66_A0128	COG1879	ABC-type sugar transport system periplasmic component
VCM66_A0129	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VCM66_A0130	COG1609	Transcriptional regulator
VCM66_A0132	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VCM66_A0134	COG0584	glycerophosphoryl diester phosphodiesterase
VCM66_A0135	COG2271	Major facilitator Superfamily
VCM66_A0145	COG0579	oxidoreductase
VCM66_A0148	COG0242	peptide deformylase activity
VCM66_A0150	COG1320	monovalent cation:proton antiporter activity
VCM66_A0151	COG2212	antiporter activity
VCM66_A0155	COG2111	Na H antiporter
VCM66_A0155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VCM66_A0157	COG0589	response to stress
VCM66_A0158	COG0814	amino acid
VCM66_A0159	COG3033	Beta-eliminating lyase
VCM66_A0161	COG3530	Putative quorum-sensing-regulated virulence factor
VCM66_A0163	COG5002	protein histidine kinase activity
VCM66_A0163	COG5001	Diguanylate cyclase
VCM66_A0164	COG1278	Cold shock
VCM66_A0167	COG2304	oxidoreductase activity
VCM66_A0171	COG0714	Associated with various cellular activities
VCM66_A0172	COG0840	transmembrane signaling receptor activity
VCM66_A0175	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VCM66_A0176	COG2195	Cleaves the N-terminal amino acid of tripeptides
VCM66_A0178	COG3604	Transcriptional regulator
VCM66_A0179	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VCM66_A0179	COG1017	nitric oxide dioxygenase activity
VCM66_A0180	COG1278	Cold shock
VCM66_A0181	COG3036	rescue of stalled ribosome
VCM66_A0187	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
VCM66_A0187	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
VCM66_A0188	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VCM66_A0190	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VCM66_A0193	COG0516	GMP reductase activity
VCM66_A0198	COG1943	Transposase
VCM66_A0200	COG0513	Belongs to the DEAD box helicase family
VCM66_A0201	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VCM66_A0203	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VCM66_A0204	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VCM66_A0206	COG0784	Response regulator, receiver
VCM66_A0206	COG3437	response regulator, receiver
VCM66_A0207	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VCM66_A0207	COG4191	Histidine kinase
VCM66_A0209	COG1757	Na H antiporter
VCM66_A0210	COG2814	Major facilitator Superfamily
VCM66_A0213	COG3706	GGDEF domain
VCM66_A0214	COG3240	lipase activity
VCM66_A0216	COG0840	transmembrane signaling receptor activity
VCM66_A0217	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
VCM66_A0218	COG5380	lipid catabolic process
VCM66_A0219	COG3291	Pkd domain containing protein
VCM66_A0219	COG4412	M6 family metalloprotease domain protein
VCM66_A0224	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VCM66_A0225	COG4605	iron ion homeostasis
VCM66_A0226	COG4604	ABC transporter, ATP-binding protein
VCM66_A0231	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VCM66_A0235	COG0745	RESPONSE REGULATOR receiver
VCM66_A0237	COG3623	hexulose-6-phosphate isomerase
VCM66_A0238	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
VCM66_A0239	COG0561	phosphatase activity
VCM66_A0245	COG3038	cytochrome b561
VCM66_A0246	COG0366	Alpha amylase catalytic
VCM66_A0253	COG0745	RESPONSE REGULATOR receiver
VCM66_A0254	COG5002	protein histidine kinase activity
VCM66_A0260	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VCM66_A0263	COG2814	Major facilitator Superfamily
VCM66_A0266	COG1686	Belongs to the peptidase S11 family
VCM66_A0275	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VCM66_A0275	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VCM66_A0276	COG0509	glycine decarboxylation via glycine cleavage system
VCM66_A0277	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VCM66_A0279	COG0404	The glycine cleavage system catalyzes the degradation of glycine
VCM66_A0281	COG3039	Transposase
VCM66_A0286	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VCM66_A0288	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VCM66_A0289	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
VCM66_A0306	COG3040	lipid binding
VCM66_A0323	COG1418	mRNA catabolic process
VCM66_A0338	COG1028	Short-chain dehydrogenase reductase Sdr
VCM66_A0345	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VCM66_A0350	COG0494	nUDIX hydrolase
VCM66_A0355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VCM66_A0356	COG3040	lipid binding
VCM66_A0362	COG3041	Addiction module toxin RelE StbE family
VCM66_A0369	COG1619	proteins homologs of microcin C7 resistance protein MccF
VCM66_A0371	COG3549	Plasmid maintenance system killer
VCM66_A0372	COG3093	addiction module antidote protein HigA
VCM66_A0400	COG3549	Plasmid maintenance system killer
VCM66_A0401	COG3093	addiction module antidote protein HigA
VCM66_A0403	COG3040	lipid binding
VCM66_A0414	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
VCM66_A0415	COG4977	sequence-specific DNA binding
VCM66_A0430	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
VCM66_A0431	COG2944	sequence-specific DNA binding
VCM66_A0434	COG3039	Transposase
VCM66_A0435	COG0110	maltose O-acetyltransferase activity
VCM66_A0438	COG0346	lactoylglutathione lyase activity
VCM66_A0453	COG1943	Transposase
VCM66_A0465	COG0346	lactoylglutathione lyase activity
VCM66_A0470	COG1328	CTP reductase activity
VCM66_A0471	COG0602	queuosine metabolic process
VCM66_A0473	COG4067	protein conserved in archaea
VCM66_A0473	COG0189	ligase activity
VCM66_A0475	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCM66_A0475	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCM66_A0475	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
VCM66_A0476	COG1105	Belongs to the carbohydrate kinase PfkB family
VCM66_A0477	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCM66_A0477	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCM66_A0478	COG1609	Transcriptional regulator
VCM66_A0479	COG0420	3'-5' exonuclease activity
VCM66_A0480	COG0419	ATPase involved in DNA repair
VCM66_A0481	COG0784	Response regulator, receiver
VCM66_A0481	COG2205	protein histidine kinase activity
VCM66_A0482	COG0156	8-amino-7-oxononanoate synthase activity
VCM66_A0485	COG0038	chloride channel
VCM66_A0486	COG0523	cobalamin synthesis protein
VCM66_A0488	COG3158	transport of potassium into the cell
VCM66_A0489	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
VCM66_A0489	COG1013	pyruvate-flavodoxin oxidoreductase activity
VCM66_A0489	COG0674	pyruvate-flavodoxin oxidoreductase activity
VCM66_A0489	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VCM66_A0490	COG2205	protein histidine kinase activity
VCM66_A0491	COG0745	RESPONSE REGULATOR receiver
VCM66_A0492	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VCM66_A0493	COG0586	Pfam SNARE associated Golgi protein
VCM66_A0495	COG2200	EAL domain
VCM66_A0497	COG3038	cytochrome b561
VCM66_A0499	COG2116	formate transmembrane transporter activity
VCM66_A0501	COG0583	DNA-binding transcription factor activity
VCM66_A0503	COG3593	DNA synthesis involved in DNA repair
VCM66_A0504	COG0737	Belongs to the 5'-nucleotidase family
VCM66_A0508	COG2824	Alkylphosphonate utilization operon protein PhnA
VCM66_A0519	COG3706	GGDEF domain
VCM66_A0522	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VCM66_A0523	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VCM66_A0525	COG0745	RESPONSE REGULATOR receiver
VCM66_A0529	COG0023	Translation Initiation Factor
VCM66_A0531	COG1181	Belongs to the D-alanine--D-alanine ligase family
VCM66_A0533	COG0045	succinate-CoA ligase (ADP-forming) activity
VCM66_A0533	COG1042	CoA-binding domain protein
VCM66_A0533	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VCM66_A0534	COG0583	DNA-binding transcription factor activity
VCM66_A0535	COG1629	transport
VCM66_A0535	COG4771	TonB-dependent receptor
VCM66_A0539	COG2050	protein possibly involved in aromatic compounds catabolism
VCM66_A0543	COG0625	glutathione transferase activity
VCM66_A0546	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VCM66_A0547	COG4172	Belongs to the ABC transporter superfamily
VCM66_A0548	COG4239	(ABC) transporter, permease
VCM66_A0549	COG4174	ABC transporter (Permease)
VCM66_A0550	COG4166	transmembrane transport
VCM66_A0560	COG3842	ATPase activity
VCM66_A0562	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VCM66_A0564	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VCM66_A0565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VCM66_A0566	COG1011	Hydrolase
VCM66_A0568	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
VCM66_A0570	COG1970	mechanosensitive ion channel activity
VCM66_A0572	COG2759	Belongs to the formate--tetrahydrofolate ligase family
VCM66_A0573	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VCM66_A0573	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VCM66_A0574	COG0302	gtp cyclohydrolase
VCM66_A0576	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VCM66_A0578	COG2897	thiosulfate sulfurtransferase activity
VCM66_A0579	COG2390	Transcriptional regulator
VCM66_A0581	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VCM66_A0582	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VCM66_A0588	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VCM66_A0593	COG0583	DNA-binding transcription factor activity
VCM66_A0594	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
VCM66_A0595	COG0778	Nitroreductase
VCM66_A0600	COG0640	Transcriptional regulator
VCM66_A0602	COG0446	pyridine nucleotide-disulphide oxidoreductase
VCM66_A0611	COG1263	PTS System
VCM66_A0611	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VCM66_A0613	COG1621	beta-fructofuranosidase activity
VCM66_A0614	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VCM66_A0615	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VCM66_A0617	COG2885	chlorophyll binding
VCM66_A0619	COG0545	Peptidyl-prolyl cis-trans isomerase
VCM66_A0620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VCM66_A0621	COG0840	transmembrane signaling receptor activity
VCM66_A0623	COG3069	C4-dicarboxylate transmembrane transporter activity
VCM66_A0624	COG1760	l-serine dehydratase
VCM66_A0631	COG1609	Transcriptional regulator
VCM66_A0632	COG2197	response regulator
VCM66_A0633	COG3850	Histidine kinase
VCM66_A0634	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VCM66_A0636	COG0243	molybdopterin cofactor binding
VCM66_A0639	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VCM66_A0640	COG2197	response regulator
VCM66_A0641	COG3851	Histidine kinase
VCM66_A0642	COG2271	Major facilitator Superfamily
VCM66_A0643	COG1840	ABC-type Fe3 transport system, periplasmic component
VCM66_A0645	COG3842	ATPase activity
VCM66_A0646	COG3243	poly(R)-hydroxyalkanoic acid synthase
VCM66_A0648	COG0183	Belongs to the thiolase family
VCM66_A0650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VCM66_A0651	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VCM66_A0655	COG3706	GGDEF domain
VCM66_A0657	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VCM66_A0660	COG1979	alcohol dehydrogenase
VCM66_A0663	COG4191	Histidine kinase
VCM66_A0664	COG1840	ABC-type Fe3 transport system, periplasmic component
VCM66_A0665	COG2271	Major facilitator Superfamily
VCM66_A0666	COG0469	pyruvate kinase activity
VCM66_A0667	COG2198	Histidine kinase
VCM66_A0667	COG0784	Response regulator, receiver
VCM66_A0667	COG2205	protein histidine kinase activity
VCM66_A0668	COG1879	ABC-type sugar transport system periplasmic component
VCM66_A0669	COG1803	Methylglyoxal synthase
VCM66_A0670	COG1335	isochorismatase
VCM66_A0672	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VCM66_A0675	COG0210	DNA helicase
VCM66_A0676	COG1289	transmembrane transporter activity
VCM66_A0682	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
VCM66_A0683	COG4149	molybdate abc transporter
VCM66_A0684	COG0725	ABC transporter, periplasmic molybdate-binding protein
VCM66_A0685	COG1492	cobalamin metabolic process
VCM66_A0694	COG5002	protein histidine kinase activity
VCM66_A0694	COG0784	Response regulator, receiver
VCM66_A0695	COG1879	ABC-type sugar transport system periplasmic component
VCM66_A0697	COG2827	Endonuclease containing a URI domain
VCM66_A0704	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VCM66_A0706	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VCM66_A0708	COG0247	lactate metabolic process
VCM66_A0710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VCM66_A0711	COG3118	belongs to the thioredoxin family
VCM66_A0715	COG0583	DNA-binding transcription factor activity
VCM66_A0716	COG4160	amino acid transport
VCM66_A0717	COG4215	(ABC) transporter
VCM66_A0718	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VCM66_A0719	COG1126	abc transporter atp-binding protein
VCM66_A0721	COG2425	protein containing a von Willebrand factor type A (vWA) domain
VCM66_A0723	COG0494	nUDIX hydrolase
VCM66_A0724	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
VCM66_A0726	COG1309	transcriptional regulator
VCM66_A0727	COG0513	Belongs to the DEAD box helicase family
VCM66_A0728	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
VCM66_A0731	COG0814	amino acid
VCM66_A0732	COG0840	transmembrane signaling receptor activity
VCM66_A0733	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VCM66_A0735	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VCM66_A0737	COG1984	allophanate hydrolase subunit 2
VCM66_A0740	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
VCM66_A0741	COG4181	ATPase activity
VCM66_A0743	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VCM66_A0744	COG1716	ATPase activity
VCM66_A0744	COG5001	Diguanylate cyclase
VCM66_A0747	COG0484	heat shock protein binding
VCM66_A0757	COG0546	phosphoglycolate phosphatase activity
VCM66_A0760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VCM66_A0761	COG1368	sulfuric ester hydrolase activity
VCM66_A0763	COG0513	Belongs to the DEAD box helicase family
VCM66_A0764	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
VCM66_A0766	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VCM66_A0768	COG3046	protein related to deoxyribodipyrimidine photolyase
VCM66_A0771	COG3227	Zinc metalloprotease (Elastase)
VCM66_A0773	COG0010	Belongs to the arginase family
VCM66_A0774	COG1166	arginine decarboxylase activity
VCM66_A0777	COG2239	Acts as a magnesium transporter
VCM66_A0778	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VCM66_A0779	COG0459	protein refolding
VCM66_A0781	COG0527	aspartate kinase activity
VCM66_A0782	COG0662	Cupin 2, conserved barrel domain protein
VCM66_A0783	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VCM66_A0784	COG0456	acetyltransferase
VCM66_A0786	COG2154	pterin-4-alpha-carbinolamine dehydratase
VCM66_A0787	COG3186	Phenylalanine-4-hydroxylase
VCM66_A0788	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VCM66_A0791	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VCM66_A0792	COG0583	DNA-binding transcription factor activity
VCM66_A0795	COG2171	N-acyltransferase activity
VCM66_A0796	COG1253	flavin adenine dinucleotide binding
VCM66_A0797	COG1765	OsmC-like protein
VCM66_A0806	COG0531	amino acid
VCM66_A0807	COG3706	GGDEF domain
VCM66_A0809	COG3279	Response regulator of the LytR AlgR family
VCM66_A0810	COG3275	phosphorelay sensor kinase activity
VCM66_A0813	COG1136	(ABC) transporter
VCM66_A0813	COG0577	efflux transmembrane transporter activity
VCM66_A0814	COG1136	(ABC) transporter
VCM66_A0818	COG4989	oxidoreductase activity
VCM66_A0819	COG0366	Alpha amylase catalytic
VCM66_A0821	COG2067	long-chain fatty acid transport protein
VCM66_A0822	COG2267	carboxylic ester hydrolase activity
VCM66_A0824	COG3227	Zinc metalloprotease (Elastase)
VCM66_A0826	COG3047	cAMP biosynthetic process
VCM66_A0829	COG1686	Belongs to the peptidase S11 family
VCM66_A0830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VCM66_A0831	COG1271	oxidase subunit
VCM66_A0832	COG1294	oxidase, subunit
VCM66_A0834	COG3048	D-serine ammonia-lyase activity
VCM66_A0835	COG0583	DNA-binding transcription factor activity
VCM66_A0845	COG1063	alcohol dehydrogenase
VCM66_A0850	COG0346	lactoylglutathione lyase activity
VCM66_A0855	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VCM66_A0856	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VCM66_A0857	COG0363	glucosamine-6-phosphate deaminase activity
VCM66_A0858	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VCM66_A0863	COG1929	Belongs to the glycerate kinase type-1 family
VCM66_A0864	COG2610	gluconate transmembrane transporter activity
VCM66_A0865	COG3835	regulator
VCM66_A0867	COG0748	coenzyme F420 binding
VCM66_A0868	COG3721	Heme iron utilization protein
VCM66_A0870	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VCM66_A0871	COG0811	peptide transport
VCM66_A0872	COG0848	biopolymer transport protein
VCM66_A0873	COG4558	Periplasmic binding protein
VCM66_A0874	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VCM66_A0875	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VCM66_A0884	COG3217	Mosc domain protein beta barrel domain protein
VCM66_A0884	COG3217	Mosc domain protein beta barrel domain protein
VCM66_A0884	COG0633	Ferredoxin
VCM66_A0884	COG0633	Ferredoxin
VCM66_A0885	COG0418	dihydroorotase activity
VCM66_A0887	COG3152	Membrane
VCM66_A0889	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VCM66_A0890	COG2354	Protein conserved in bacteria
VCM66_A0891	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VCM66_A0893	COG1278	Cold shock
VCM66_A0899	COG3706	GGDEF domain
VCM66_A0900	COG1349	DNA-binding transcription factor activity
VCM66_A0903	COG3833	ABC-type maltose transport systems, permease component
VCM66_A0904	COG1175	transmembrane transport
VCM66_A0906	COG3842	ATPase activity
VCM66_A0907	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VCM66_A0911	COG0393	Putative heavy-metal-binding
VCM66_A0912	COG2197	response regulator
VCM66_A0913	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VCM66_A0914	COG0784	Response regulator, receiver
VCM66_A0914	COG0835	chemotaxis
VCM66_A0915	COG1846	Transcriptional regulator
VCM66_A0916	COG3706	GGDEF domain
VCM66_A0924	COG0583	DNA-binding transcription factor activity
VCM66_A0925	COG5001	Diguanylate cyclase
VCM66_A0929	COG1741	Belongs to the pirin family
VCM66_A0930	COG3123	guanosine phosphorylase activity
VCM66_A0932	COG2211	Major facilitator Superfamily
VCM66_A0934	COG0840	transmembrane signaling receptor activity
VCM66_A0935	COG1067	ATP-dependent peptidase activity
VCM66_A0937	COG4172	Belongs to the ABC transporter superfamily
VCM66_A0941	COG0583	DNA-binding transcription factor activity
VCM66_A0942	COG1620	l-lactate permease
VCM66_A0943	COG1304	FMN binding
VCM66_A0945	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
VCM66_A0947	COG0840	transmembrane signaling receptor activity
VCM66_A0949	COG0513	Belongs to the DEAD box helicase family
VCM66_A0950	COG0583	DNA-binding transcription factor activity
VCM66_A0952	COG1902	pentaerythritol trinitrate reductase activity
VCM66_A0955	COG1132	(ABC) transporter
VCM66_A0957	COG1902	pentaerythritol trinitrate reductase activity
VCM66_A0959	COG1280	lysine exporter protein (LysE YggA)
VCM66_A0960	COG2207	Transcriptional regulator
VCM66_A0964	COG1846	Transcriptional regulator
VCM66_A0965	COG1764	response to oxidative stress
VCM66_A0967	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VCM66_A0969	COG0697	spore germination
VCM66_A0971	COG0700	Nucleoside recognition
VCM66_A0972	COG3366	ferrous iron transmembrane transporter activity
VCM66_A0974	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
VCM66_A0976	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VCM66_A0977	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
VCM66_A0978	COG2259	Doxx family
VCM66_A0983	COG0363	glucosamine-6-phosphate deaminase activity
VCM66_A0986	COG4580	involved in the transport of maltose and maltodextrins
VCM66_A0989	COG0840	transmembrane signaling receptor activity
VCM66_A0992	COG0840	transmembrane signaling receptor activity
VCM66_A0994	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VCM66_A0995	COG1126	abc transporter atp-binding protein
VCM66_A0997	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VCM66_A0998	COG4597	amino acid ABC transporter
VCM66_A0999	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VCM66_A1001	COG0739	heme binding
VCM66_A1003	COG2213	PTS system mannitol-specific
VCM66_A1003	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCM66_A1004	COG0246	Mannitol dehydrogenase
VCM66_A1005	COG3722	fumarate hydratase activity
VCM66_A1006	COG0673	inositol 2-dehydrogenase activity
VCM66_A1012	COG2910	NAD(P)H-binding
VCM66_A1014	COG0840	transmembrane signaling receptor activity
VCM66_A1015	COG4221	oxidoreductase activity
VCM66_A1017	COG1901	pseudouridine methyltransferase
VCM66_A1018	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VCM66_A1020	COG0531	amino acid
VCM66_A1021	COG1982	Orn Lys Arg decarboxylase major
VCM66_A1029	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VCM66_A1035	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VCM66_A1037	COG0259	pyridoxamine-phosphate oxidase activity
VCM66_A1043	COG0745	RESPONSE REGULATOR receiver
VCM66_A1047	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
VCM66_A1048	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VCM66_A1049	COG0840	transmembrane signaling receptor activity
VCM66_A1050	COG0835	chemotaxis
VCM66_A1051	COG0835	chemotaxis
VCM66_A1052	COG2198	Histidine kinase
VCM66_A1052	COG0643	Histidine kinase
VCM66_A1056	COG0601	transmembrane transport
VCM66_A1057	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VCM66_A1059	COG2194	sulfuric ester hydrolase activity
VCM66_A1061	COG0642	Histidine kinase
VCM66_A1062	COG0745	RESPONSE REGULATOR receiver
VCM66_A1068	COG1444	tRNA N-acetyltransferase activity
VCM66_A1069	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine