locus-tag class description VCD_000005 ENOG4105DS1 cytochrome b561 VCD_000011 ENOG410667J hydrolase VCD_000013 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase VCD_000016 ENOG4105ETX regulatoR VCD_000020 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) VCD_000024 ENOG4108IPW abc transporter atp-binding protein VCD_000025 ENOG4105CM4 permease protein VCD_000026 ENOG4105DHS permease protein VCD_000030 ENOG4107G87 m6 family metalloprotease domain protein VCD_000032 ENOG4107IFA Lipase (EC 3.1.1.3) VCD_000033 ENOG4108N3W hemolysin secretion protein VCD_000034 ENOG4106M3D hemolysin VCD_000035 ENOG4105KUU lipolytic protein G-D-S-L family VCD_000036 ENOG4105BZU Histidine kinase VCD_000039 ENOG4105E5M Multidrug resistance protein D VCD_000040 ENOG4107S6Z Na H antiporter VCD_000042 ENOG4105BZU Histidine kinase VCD_000043 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase VCD_000044 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) VCD_000045 ENOG4107RA1 nh(3)-dependent nad( ) synthetase VCD_000046 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter VCD_000047 ENOG4105C1J atp-dependent rna helicase VCD_000048 ENOG4108RS6 transposase VCD_000053 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) VCD_000057 ENOG4105C5I Dehydrogenase VCD_000058 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) VCD_000060 ENOG4108UNF response regulator VCD_000065 ENOG4105VEQ Cold shock protein VCD_000066 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) VCD_000067 ENOG4108JUA Transcriptional regulator VCD_000070 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) VCD_000071 ENOG4105D9N nucleoside VCD_000074 ENOG41069D7 Methyl-accepting chemotaxis VCD_000075 ENOG4105C7R Atpase associated with various cellular activities aaa_3 VCD_000082 ENOG4105VEQ Cold shock protein VCD_000083 ENOG4105BZU Histidine kinase VCD_000085 ENOG4105VRT cytoplasmic protein VCD_000086 ENOG4105C0F tryptophanase EC 4.1.99.1 VCD_000087 ENOG4105CIC tryptophan-specific transport protein VCD_000088 ENOG4105Q9Y Universal stress protein VCD_000090 ENOG4105D65 subunit l VCD_000091 ENOG4105MKQ Monovalent cation H antiporter subunit C VCD_000092 ENOG4108JPZ Monovalent cation H antiporter subunit D VCD_000093 ENOG4105SC1 monovalent cation H antiporter subunit E VCD_000094 ENOG41080TA Multiple resistance and ph regulation protein f VCD_000095 ENOG4105KJM monovalent cation h antiporter subunit g VCD_000097 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) VCD_000100 ENOG4105D5U fad dependent oxidoreductase VCD_000104 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VCD_000105 ENOG4105CQZ Histidine kinase VCD_000108 ENOG4105CXY transporter VCD_000109 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase VCD_000111 ENOG4108I5U Uridine phosphorylase VCD_000114 ENOG4105ETE Transcriptional regulator (LacI family VCD_000115 ENOG4108RVA ribokinase VCD_000116 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator VCD_000117 ENOG4105CNN ABC, transporter VCD_000118 ENOG4105C2J ABC transporter VCD_000119 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) VCD_000122 ENOG4105CS6 Rhs element vgr protein VCD_000127 ENOG4108JUB Transcriptional regulator VCD_000128 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit VCD_000140 ENOG4105D3G Pseudouridine synthase VCD_000142 ENOG4107VXZ Hydrolase VCD_000143 ENOG4105BZU Histidine kinase VCD_000145 ENOG4105D9R oxidoreductase VCD_000146 ENOG4107RH7 Nicotinate phosphoribosyltransferase VCD_000153 ENOG4105CK2 sodium dicarboxylate symporter VCD_000157 ENOG4108Z4X TRANSCRIPTIONal VCD_000158 ENOG4105E5M Multidrug resistance protein D VCD_000159 ENOG4105EQ2 LysR family Transcriptional regulator VCD_000160 ENOG4105BZU Histidine kinase VCD_000161 ENOG4105DR5 peptidase VCD_000163 ENOG4105CHH sulfate transporter VCD_000164 ENOG4105DWD nucleoside recognition domain protein VCD_000166 ENOG4105BZU Histidine kinase VCD_000167 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) VCD_000168 ENOG4105E2Z phosphate ABC transporter (Permease VCD_000169 ENOG4105C8U phosphate abc transporter VCD_000170 ENOG4105CVA phosphate VCD_000176 ENOG4105CUG Oligopeptidase b VCD_000177 ENOG4105C1J atp-dependent rna helicase VCD_000180 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein VCD_000181 ENOG4105CVP deoxyribo-dipyrimidine photolyase VCD_000183 ENOG4107SEY Conserved Protein VCD_000184 ENOG4105D3A purine nucleoside phosphorylase DeoD-type VCD_000187 ENOG4106TD9 Diguanylate cyclase VCD_000188 ENOG4105KK7 inner membrane protein YiaW VCD_000189 ENOG4105EFX secretion protein, HlyD family VCD_000192 ENOG4105YE1 PilZ domain VCD_000193 ENOG4105D6U Sodium Glutamate Symporter VCD_000198 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) VCD_000199 ENOG4105EYK Phosphatidylglycerophosphatase B VCD_000203 ENOG4105C8Q Methyl-accepting chemotaxis VCD_000207 ENOG4108Q67 UPF0319 protein VCD_000208 ENOG4105C8P )-transporter VCD_000210 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) VCD_000215 ENOG4105CS6 Rhs element vgr protein VCD_000216 ENOG4108WC9 type VI secretion system effector, hcp1 family VCD_000217 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) VCD_000218 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) VCD_000219 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) VCD_000220 ENOG41061ZR Transcriptional regulator VCD_000221 ENOG4108YYI Protein of unknown function (DUF2810) VCD_000222 ENOG4105C8Q Methyl-accepting chemotaxis VCD_000223 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase VCD_000224 ENOG4105CDY transcriptional regulatory protein VCD_000230 ENOG4106RMF ParB family VCD_000231 ENOG4107RUE extracellular solute-binding protein family 1 VCD_000232 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) VCD_000238 ENOG4105XJC Two component transcriptional regulator (Winged helix family VCD_000239 ENOG4105DHQ Histidine kinase VCD_000241 ENOG4105DIJ Phosphoethanolamine transferase VCD_000242 ENOG4108JQ6 ABC transporter VCD_000243 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VCD_000244 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component VCD_000247 ENOG4108VYJ response regulator receiver protein VCD_000248 ENOG4105CBS Chea signal transduction histidine kinase VCD_000249 ENOG4108V3W Chemotaxis protein, CheW VCD_000250 ENOG4108V3W Chemotaxis protein, CheW VCD_000251 ENOG4105C8Q Methyl-accepting chemotaxis VCD_000252 ENOG4105BZU Histidine kinase VCD_000253 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) VCD_000254 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) VCD_000255 ENOG4105C8Q Methyl-accepting chemotaxis VCD_000257 ENOG4105CK6 Two component transcriptional regulator (Winged helix family VCD_000259 ENOG4108JJA ABC, transporter VCD_000262 ENOG4107QZV Type I secretion membrane fusion protein VCD_000263 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) VCD_000265 ENOG4105E6M Sulphatase-modifying factor protein VCD_000269 ENOG4105C26 Dehydrogenase VCD_000271 ENOG4105CK7 Sodium proline symporter VCD_000273 ENOG4105C8Q Methyl-accepting chemotaxis VCD_000274 ENOG4105EW9 transcriptional regulator AsnC family VCD_000275 ENOG4107RGH Aldehyde dehydrogenase VCD_000277 ENOG4105CXN decarboxylase VCD_000278 ENOG4105D5Q Arginine ornithine antiporter VCD_000280 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) VCD_000282 ENOG4105JQN Transcriptional regulator VCD_000283 ENOG4105EMU Dehydrogenase VCD_000284 ENOG41069D7 Methyl-accepting chemotaxis VCD_000285 ENOG4105JQN Transcriptional regulator VCD_000286 ENOG4108RYK Nad-dependent epimerase dehydratase VCD_000292 ENOG4105EP9 oxidoreductase VCD_000293 ENOG4105E61 Mannitol repressor protein VCD_000294 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase VCD_000295 ENOG4105CTS PTS system mannitol-specific VCD_000297 ENOG4105DR5 peptidase VCD_000299 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain VCD_000300 ENOG4105EZ7 amino acid ABC transporter VCD_000301 ENOG4106TNF Periplasmic binding protein VCD_000303 ENOG4105CDA abc transporter atp-binding protein VCD_000304 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) VCD_000306 ENOG4105C8Q Methyl-accepting chemotaxis VCD_000310 ENOG4108N3W hemolysin secretion protein VCD_000313 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) VCD_000314 ENOG4107W52 maltose operon periplasmic protein VCD_000316 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) VCD_000321 ENOG4108VGI doxx family VCD_000322 ENOG4105D03 DNA-3-methyladenine glycosylase II VCD_000323 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) VCD_000325 ENOG4105DN9 Na H antiporter VCD_000326 ENOG41074DU domain protein VCD_000327 ENOG4108P2H Inner membrane protein YjiG VCD_000328 ENOG4105VW4 glutaredoxin 3 VCD_000329 ENOG4108SXK Transporter Drug Metabolite Exporter family VCD_000332 ENOG4108ZHJ Organic hydroperoxide resistance protein VCD_000333 ENOG4105K56 Transcriptional regulator VCD_000340 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase VCD_000342 ENOG4105BZ1 (ABC) transporter VCD_000345 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase VCD_000347 ENOG4105CR8 Transcriptional regulator VCD_000348 ENOG4105C1J atp-dependent rna helicase VCD_000350 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor VCD_000352 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) VCD_000354 ENOG4105DMF Dehydrogenase VCD_000355 ENOG4105DAA L-lactate VCD_000356 ENOG4105CC0 LysR family Transcriptional regulator VCD_000360 ENOG4105E89 ABC transporter VCD_000361 ENOG4108JQ5 ABC transporter VCD_000363 ENOG4105DAN ATP-dependent protease VCD_000364 ENOG4105C8Q Methyl-accepting chemotaxis VCD_000365 ENOG4105E5W Transporter VCD_000367 ENOG4105NBK UPF0345 protein VCD_000368 ENOG4105EUB pirin domain protein VCD_000370 ENOG4108K0B C-di-gmp phosphodiesterase VCD_000371 ENOG4105ETT transcriptional Regulator, LysR family VCD_000375 ENOG4105BZU Histidine kinase VCD_000378 ENOG4106TD9 Diguanylate cyclase VCD_000379 ENOG4105K56 Transcriptional regulator VCD_000380 ENOG4107R88 Chemotaxis protein (CheV) VCD_000381 ENOG4105KQ5 peptidylprolyl cis-trans isomerase VCD_000383 ENOG41086KC Transcriptional regulator VCD_000384 ENOG4105K8R UPF0145 protein VCD_000387 ENOG4108HK0 -acetyltransferase VCD_000388 ENOG4108IJ9 (ABC) transporter VCD_000389 ENOG4107FKK extracellular solute-binding protein family 1 VCD_000390 ENOG4105D56 permease protein VCD_000391 ENOG4105EG2 ABC transporter, permease VCD_000394 ENOG4105E98 transcriptional regulator DeoR family VCD_000395 ENOG4105BZU Histidine kinase VCD_000397 ENOG4105EQD regulatoR VCD_000400 ENOG4105VEQ Cold shock protein VCD_000401 ENOG4108ESY Metal dependent phosphohydrolase VCD_000402 ENOG4105CKW Inner membrane protein yedI VCD_000403 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) VCD_000405 ENOG4105KAF membrAne VCD_000407 ENOG4105EKE dihydroorotase VCD_000408 ENOG4105QVC MOSC domain-containing protein VCD_000408 ENOG4105QVC MOSC domain-containing protein VCD_000409 ENOG4105C8Q Methyl-accepting chemotaxis VCD_000416 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) VCD_000417 ENOG4105EHG Permease protein VCD_000418 ENOG4107R4I Periplasmic binding protein VCD_000419 ENOG4106GFD transport protein VCD_000420 ENOG41090AP transport protein VCD_000421 ENOG4105WQ5 TonB family VCD_000422 ENOG4105D4P Coproporphyrinogen iii oxidase VCD_000423 ENOG41090JE Utilization Protein VCD_000424 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related VCD_000425 ENOG4108NVR Methyl-accepting chemotaxis VCD_000426 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR VCD_000427 ENOG4105C6Z Gluconate VCD_000428 ENOG4105BZW Glycerate kinase VCD_000433 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) VCD_000434 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) VCD_000435 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase VCD_000436 ENOG4105DHT Metal Dependent Phosphohydrolase VCD_000437 ENOG4107SSZ Phosphatase VCD_000441 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase VCD_000442 ENOG4105EXG Transcriptional regulator VCD_000447 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) VCD_000448 ENOG4105CPQ Dehydrogenase VCD_000457 ENOG4105W8I Transcriptional regulator VCD_000458 ENOG4105BZC d-serine deaminase VCD_000460 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii VCD_000461 ENOG4105C4M (Ubiquinol oxidase) subunit I VCD_000462 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family VCD_000463 ENOG41061WM D-Alanyl-D-Alanine VCD_000465 ENOG4105EIF outer membrane protein W VCD_000466 ENOG4105D4Y metalloprotease VCD_000467 ENOG4107SDU Methyl-accepting chemotaxis VCD_000468 ENOG4108M0H Extracellular lipase VCD_000469 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation VCD_000470 ENOG4107T9C Alpha amylase catalytic region VCD_000471 ENOG4107RGM aldo keto reductase VCD_000474 ENOG4105C19 ABC transporter VCD_000475 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) VCD_000478 ENOG4108HRK Histidine kinase VCD_000479 ENOG4108VAC response regulator VCD_000481 ENOG4106TD9 Diguanylate cyclase VCD_000482 ENOG4105DVH amino acid VCD_000487 ENOG4107YWA deoxycytidylate deaminase VCD_000488 ENOG4108UKZ OsmC family VCD_000489 ENOG4105C37 (CBS) domain VCD_000490 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) VCD_000493 ENOG4105EGI Transcriptional regulator VCD_000494 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) VCD_000496 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) VCD_000497 ENOG4105MIR Phenylalanine 4-monooxygenase VCD_000498 ENOG41090A4 Pterin carbinolamine dehydratase VCD_000499 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase VCD_000500 ENOG4108JPW Aminotransferase VCD_000501 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) VCD_000502 ENOG4105CZK Aspartate kinase VCD_000504 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) VCD_000505 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) VCD_000506 ENOG4105CJW magnesium transporter VCD_000509 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) VCD_000510 ENOG4105CYW agmatinase VCD_000512 ENOG4105D4Y metalloprotease VCD_000513 ENOG4108M1A Chitin-binding protein VCD_000514 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein VCD_000516 ENOG4105CVA phosphate VCD_000518 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) VCD_000519 ENOG4105C1J atp-dependent rna helicase VCD_000521 ENOG4105E0M Sulfatase VCD_000522 ENOG4107RE1 Inosine-guanosine kinase VCD_000525 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) VCD_000534 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) VCD_000538 ENOG4105RKW reductase (By VCD_000540 ENOG4108I0Y (ABC) transporter VCD_000541 ENOG4105CV6 ABC transporter, permease VCD_000542 ENOG4105C6Y Udp-glucose 6-dehydrogenase VCD_000544 ENOG4107R7A Allophanate hydrolase subunit 2 VCD_000546 ENOG4105E7W lamb ycsf family protein VCD_000547 ENOG4105CMR udp-glucose 4-epimerase VCD_000548 ENOG4108N3W hemolysin secretion protein VCD_000549 ENOG4105E0U tyrosine-specific transport protein VCD_000551 ENOG4108ZYK Acyl carrier protein phosphodiesterase VCD_000552 ENOG4105C1J atp-dependent rna helicase VCD_000553 ENOG4108IG5 Transcriptional regulator VCD_000554 ENOG4106RE7 Cytochrome VCD_000555 ENOG4105C5W Aldolase VCD_000556 ENOG4108YZ4 nudix hydrolase VCD_000558 ENOG4105EV2 VWA domain protein interacting with AAA ATPase VCD_000560 ENOG4105E5Z arginine transporter ATP-binding subunit VCD_000561 ENOG4106PMH Extracellular solute-binding protein family 3 VCD_000562 ENOG4105GBT ABC transporter VCD_000563 ENOG4105DMR ABC, transporter VCD_000564 ENOG4105DUM transcriptional regulator, lysR family VCD_000568 ENOG4105K63 Thioredoxin VCD_000569 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) VCD_000570 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) VCD_000571 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B VCD_000572 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A VCD_000574 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) VCD_000575 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) VCD_000581 ENOG41082IR Excinuclease ABC C subunit domain protein VCD_000583 ENOG4108QGH periplasmic VCD_000584 ENOG4105BZU Histidine kinase VCD_000592 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) VCD_000593 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein VCD_000594 ENOG4105E0C molybdate abc transporter VCD_000595 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) VCD_000601 ENOG4105EM2 membrane VCD_000602 ENOG41088T4 Helicase IV VCD_000605 ENOG41080IJ Diacylglycerol kinase VCD_000607 ENOG4108RWI nicotinamidase VCD_000608 ENOG4108Z5K methylglyoxal synthase VCD_000609 ENOG4108SV3 Tmao reductase system periplasmic protein tort VCD_000610 ENOG4105BZU Histidine kinase VCD_000611 ENOG4105CA9 Pyruvate kinase VCD_000612 ENOG4105CXY transporter VCD_000613 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC VCD_000615 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta VCD_000617 ENOG4108I6A alcohol dehydrogenase VCD_000619 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) VCD_000620 ENOG4105BZU Histidine kinase VCD_000626 ENOG4108ZXE VCD_000629 ENOG4108UK2 deaminase VCD_000632 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) VCD_000633 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) VCD_000635 ENOG4105CHU acetyl-coa acetyltransferase VCD_000637 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class VCD_000638 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) VCD_000639 ENOG4107RCV ABC transporter, permease VCD_000640 ENOG4105C4Y ABC transporter VCD_000641 ENOG4105CXY transporter VCD_000642 ENOG4105BZU Histidine kinase VCD_000643 ENOG4108KX4 response regulator VCD_000644 ENOG4105DHT Metal Dependent Phosphohydrolase VCD_000648 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) VCD_000651 ENOG4105BZU Histidine kinase VCD_000652 ENOG4105WH1 Two component transcriptional regulator luxr family VCD_000653 ENOG4105ETE Transcriptional regulator (LacI family VCD_000658 ENOG4105EJQ L-serine dehydratase VCD_000659 ENOG4105CEE C4-dicarboxylate transporter VCD_000660 ENOG4108N3W hemolysin secretion protein VCD_000661 ENOG4107VXZ Hydrolase VCD_000662 ENOG4108V1T peptidylprolyl cis-trans isomerase VCD_000663 ENOG4108ZG0 Ompa motb domain protein VCD_000664 ENOG4108NVR Methyl-accepting chemotaxis VCD_000665 ENOG4105C6V Glycerol-3-phosphate dehydrogenase VCD_000666 ENOG4105D7K pfkb domain protein VCD_000667 ENOG4107R3K hydrolase VCD_000668 ENOG4105ETE Transcriptional regulator (LacI family VCD_000669 ENOG4105C5Y PTS System VCD_000678 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase VCD_000680 ENOG41080HT Transcriptional regulator, arsr family VCD_000685 ENOG4108RCM Nitroreductase VCD_000686 ENOG41067V3 Antibiotic biosynthesis monooxygenase VCD_000687 ENOG4105ETT transcriptional Regulator, LysR family VCD_000689 ENOG4105RA2 Membrane VCD_000692 ENOG4108M3J Dehydrogenase VCD_000697 ENOG4105CV1 Transketolase (EC 2.2.1.1) VCD_000698 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) VCD_000700 ENOG4107RHR regulatoR VCD_000701 ENOG4105KHC sulfurtransferase VCD_000703 ENOG4105D06 uba thif-type nad fad binding protein VCD_000704 ENOG4105CVM Molybdenum cofactor synthesis domain protein VCD_000705 ENOG4105EUJ GTP cyclohydrolase i VCD_000706 ENOG4105E0X reductase VCD_000707 ENOG4105CKU formyltetrahydrofolate synthetase VCD_000708 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) VCD_000709 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain VCD_000711 ENOG4105PAD Hydrolase VCD_000712 ENOG4105NXH GreA GreB family elongation factor VCD_000713 ENOG4108KAZ Involved in phosphonate degradation (By similarity) VCD_000714 ENOG4108JPW Aminotransferase VCD_000715 ENOG4107STF Involved in phosphonate degradation (By similarity) VCD_000718 ENOG4107RCV ABC transporter, permease VCD_000721 ENOG4105DUX Transporter VCD_000726 ENOG4105E43 Extracellular solute-binding protein, family 5 VCD_000727 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component VCD_000728 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component VCD_000729 ENOG4108JQ5 ABC transporter VCD_000730 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) VCD_000733 ENOG4105CYM Glutathione S-transferase VCD_000738 ENOG4105KA0 thioesterase Superfamily protein VCD_000743 ENOG4105CWB LysR family transcriptional Regulator VCD_000744 ENOG4105CD5 CoA-binding domain protein VCD_000746 ENOG4105CPF Cell wall formation (By similarity) VCD_000748 ENOG4108ZJT translation initiation factor, Sui1 VCD_000750 ENOG4107927 Cholera enterotoxin, A subunit VCD_000751 ENOG4105MQ5 zona occludens toxin VCD_000757 ENOG41067QW Transcriptional regulator VCD_000762 ENOG4105CK6 Two component transcriptional regulator (Winged helix family VCD_000764 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) VCD_000765 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) VCD_000768 ENOG4105BZU Histidine kinase VCD_000770 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) VCD_000771 ENOG4105BZU Histidine kinase VCD_000778 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA VCD_000781 ENOG4105DU1 integral membrane protein, terc VCD_000782 ENOG4105CGH 5'-nucleotidase VCD_000783 ENOG4105CPB ATP-dependent endonuclease of the OLD family VCD_000784 ENOG4108UQ5 membrane protein YcdZ VCD_000785 ENOG4105DUM transcriptional regulator, lysR family VCD_000787 ENOG4105TMB Formate nitrite transporter VCD_000789 ENOG4105DS1 cytochrome b561 VCD_000791 ENOG4105EPM Diguanylate phosphodiesterase VCD_000794 ENOG4108RHM integral membrane protein VCD_000795 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) VCD_000796 ENOG4105EEX Two component transcriptional regulator (Winged helix family VCD_000797 ENOG4105C08 Histidine kinase VCD_000798 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) VCD_000799 ENOG4105DFH Transport of potassium into the cell (By similarity) VCD_000800 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) VCD_000801 ENOG4105CKI cobalamin synthesis protein VCD_000802 ENOG4105CMQ Chloride channel VCD_000804 ENOG4107KBT 8-Amino-7-oxononanoate synthase VCD_000805 ENOG4108MGY Histidine kinase VCD_000806 ENOG4105EYH Exonuclease VCD_000807 ENOG4107RFY SbcCD D subunit VCD_000808 ENOG4107B7Y DNA-binding transcriptional regulator FruR VCD_000809 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein VCD_000810 ENOG4105DE4 1-phosphofructokinase VCD_000811 ENOG4105DM4 PTS System VCD_000813 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) VCD_000814 ENOG4105CGF Aromatic amino acid aminotransferase VCD_000815 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) VCD_000816 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase VCD_000820 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase VCD_000832 ENOG4108RS6 transposase VCD_000863 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase VCD_000866 ENOG4105EQK -acetyltransferase VCD_000867 ENOG4105F2I Transposase VCD_000869 ENOG4105W08 virulence gene repressor rsal VCD_000870 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system VCD_000873 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase VCD_000881 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein VCD_000889 ENOG4105QNF Outer membrane lipoprotein VCD_000892 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A VCD_000895 ENOG4105VDM plasmid maintenance system antidote protein, xre family VCD_000896 ENOG41080ET plasmid maintenance system killer protein VCD_000930 ENOG4105N14 lysine exporter protein LysE YggA VCD_000931 ENOG4105YGK Pfam:UPF0157 VCD_000933 ENOG4105QNF Outer membrane lipoprotein VCD_000936 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase VCD_000941 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase VCD_000944 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A VCD_000952 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase VCD_000963 ENOG4105QNF Outer membrane lipoprotein VCD_000964 ENOG4105D9U N-acetyltransferase VCD_000970 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein VCD_000979 ENOG4105CYX Short-chain dehydrogenase reductase Sdr VCD_000985 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) VCD_000986 ENOG41082NX 50s ribosomal protein l35 VCD_000987 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) VCD_000988 ENOG4105C22 threonyL-tRNA synthetase VCD_000992 ENOG4105F2I Transposase VCD_000994 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) VCD_000996 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) VCD_000997 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) VCD_000998 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor VCD_000999 ENOG4108RS6 transposase VCD_001003 ENOG4105DZ1 carboxypeptidase VCD_001005 ENOG4105C8Q Methyl-accepting chemotaxis VCD_001006 ENOG4105C2C drug resistance transporter, Bcr CflA VCD_001009 ENOG4107QVI Methyltransferase, type 11 VCD_001015 ENOG4105BZU Histidine kinase VCD_001016 ENOG4105XJC Two component transcriptional regulator (Winged helix family VCD_001018 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) VCD_001019 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) VCD_001020 ENOG4105E3A (ABC) transporter VCD_001021 ENOG4105DA5 (ABC) transporter VCD_001022 ENOG4105CHH sulfate transporter VCD_001023 ENOG41077A9 carbonic anhydrase VCD_001024 ENOG4108UGV hypoxanthine phosphoribosyltransferase VCD_001025 ENOG410630P Transcriptional regulator VCD_001026 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) VCD_001027 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) VCD_001028 ENOG41082RQ UPF0102 protein VCD_001029 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) VCD_001030 ENOG4105W4M Transport-associated protein VCD_001031 ENOG4105KB2 stringent starvation protein b VCD_001032 ENOG4107MKT Stringent starvation protein a VCD_001033 ENOG4105EIX cytochrome c1 VCD_001034 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) VCD_001035 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) VCD_001036 ENOG4108UJD 30S ribosomal protein S9 VCD_001037 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) VCD_001038 ENOG4105D6Z AFG1 family ATPase VCD_001040 ENOG4105C0H protease VCD_001041 ENOG4105C0H protease VCD_001042 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) VCD_001043 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) VCD_001044 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) VCD_001045 ENOG4105K5M 30s ribosomal protein S16 VCD_001046 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY VCD_001047 ENOG4106KVJ cytochrome C assembly protein VCD_001048 ENOG4108JU6 CBS domain protein VCD_001049 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) VCD_001050 ENOG4105D9M gamma-glutamylcysteine synthetase VCD_001052 ENOG4105W39 Membrane VCD_001054 ENOG4105D9Q decarboxylase (Beta subunit) VCD_001055 ENOG4107QSA Oxaloacetate decarboxylase VCD_001057 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) VCD_001058 ENOG4105CFH Aspartokinase VCD_001060 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) VCD_001061 ENOG4105Y3E Modulates RecA activity (By similarity) VCD_001062 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) VCD_001064 ENOG4108IJ6 ABC transporter VCD_001065 ENOG4105ECW sulfate abc transporter VCD_001066 ENOG4108I5D sulfate abc transporter VCD_001067 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein VCD_001069 ENOG4105C6T cysteine synthase VCD_001070 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) VCD_001071 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VCD_001072 ENOG4108K5P (LipO)protein VCD_001073 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) VCD_001074 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) VCD_001075 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) VCD_001076 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) VCD_001077 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) VCD_001079 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) VCD_001080 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase VCD_001081 ENOG4107ZVW dihydroneopterin aldolase VCD_001082 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) VCD_001084 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) VCD_001085 ENOG4105VCC 30S ribosomal protein S21 VCD_001086 ENOG4105KTH gatB Yqey VCD_001087 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) VCD_001088 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VCD_001089 ENOG4105DFP Integrase VCD_001090 ENOG4105D58 Diguanylate phosphodiesterase VCD_001091 ENOG4105C8Q Methyl-accepting chemotaxis VCD_001093 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor VCD_001095 ENOG4108YGG dna repair protein VCD_001102 ENOG4105DR5 peptidase VCD_001109 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) VCD_001118 ENOG4105CH5 extracellular solute-binding protein, family 7 VCD_001119 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) VCD_001120 ENOG410804X Transcriptional regulator VCD_001121 ENOG4105CA9 Pyruvate kinase VCD_001122 ENOG4105MPN Membrane VCD_001123 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) VCD_001124 ENOG4108ZUB Lysine exporter protein (Lyse ygga) VCD_001125 ENOG4105D64 Mechanosensitive ion channel VCD_001127 ENOG4105D2N Aldolase VCD_001128 ENOG4105BZA Phosphoglycerate kinase VCD_001129 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase VCD_001130 ENOG4105D05 Receptor VCD_001131 ENOG4108R4R Iron-regulated virulence regulatory protein VCD_001133 ENOG4105CV1 Transketolase (EC 2.2.1.1) VCD_001134 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP VCD_001135 ENOG4105GPY SprT protein VCD_001136 ENOG4105RWS endonuclease I VCD_001137 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) VCD_001138 ENOG4105D7Z glutathione synthase VCD_001139 ENOG4108UJU UPF0301 protein VCD_001140 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) VCD_001141 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) VCD_001145 ENOG4105CZX twitching motility protein VCD_001146 ENOG4105DFA alanine racemase domain protein VCD_001147 ENOG4105II7 pyrroline-5-carboxylate reductase VCD_001148 ENOG4108VIA integral membrane protein VCD_001149 ENOG4105VZ9 UPF0235 protein VCD_001151 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) VCD_001152 ENOG4105CSA Coproporphyrinogen iii oxidase VCD_001153 ENOG4105CSV Glutaminase VCD_001154 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) VCD_001155 ENOG4105CEN a g-specific adenine glycosylase VCD_001156 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) VCD_001157 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division VCD_001159 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) VCD_001160 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) VCD_001161 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) VCD_001162 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) VCD_001163 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) VCD_001164 ENOG4105NWN ApaG protein VCD_001165 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) VCD_001167 ENOG4107XM3 UPF0442 protein VCD_001168 ENOG4105DWK Membrane VCD_001169 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control VCD_001170 ENOG4105K46 50S ribosomal protein l27 VCD_001171 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) VCD_001172 ENOG4105EAH synthase VCD_001175 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) VCD_001176 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) VCD_001179 ENOG41081QV Universal stress protein VCD_001185 ENOG4105CAF HipA N-terminal domain protein VCD_001188 ENOG4105CVR type I restriction-modification system VCD_001190 ENOG4105DZR Type I site-specific deoxyribonuclease VCD_001199 ENOG4105CEU Arginine dihydrolase VCD_001200 ENOG4105D1U peptidase U62 modulator of DNA gyrase VCD_001202 ENOG4105QD6 exported protein VCD_001203 ENOG4105C03 ribonuclease VCD_001204 ENOG4108Z03 MAF-like protein VCD_001205 ENOG4105VQ7 Rod shape-determining protein MreD VCD_001206 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) VCD_001207 ENOG4105DFF Rod shape-determining protein mreb VCD_001217 ENOG4105D7Q type ii secretion system VCD_001218 ENOG4107QHF type ii secretion system protein e VCD_001221 ENOG4105E4G Type IV pilus VCD_001225 ENOG41062P1 Diguanylate cyclase phosphodiesterase VCD_001226 ENOG4108UUM single-stranded DNA-binding protein VCD_001227 ENOG41086KC Transcriptional regulator VCD_001228 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase VCD_001229 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) VCD_001231 ENOG4105C5R Aminotransferase VCD_001232 ENOG4105CFH Aspartokinase VCD_001233 ENOG4105C3R Methionine synthase VCD_001234 ENOG4105EEQ Na H antiporter VCD_001237 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) VCD_001238 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) VCD_001239 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) VCD_001242 ENOG4105P4Z Phage shock protein G VCD_001244 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) VCD_001246 ENOG4105MYN Zinc uptake regulation protein VCD_001250 ENOG4107QP8 phosphohexose isomerase VCD_001251 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme VCD_001252 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) VCD_001253 ENOG4105CDU Replicative dna helicase VCD_001255 ENOG4105K9Q Binds to the 23S rRNA (By similarity) VCD_001256 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) VCD_001257 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) VCD_001258 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) VCD_001259 ENOG4108UQY Iron-storage protein VCD_001260 ENOG4105W53 bacterioferritin-associated ferredoxin VCD_001261 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) VCD_001262 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) VCD_001263 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) VCD_001264 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) VCD_001266 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) VCD_001267 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) VCD_001268 ENOG4105WWK YheO domain protein VCD_001269 ENOG4108V1T peptidylprolyl cis-trans isomerase VCD_001271 ENOG41069P5 Protein slyX homolog VCD_001273 ENOG4105EPW hflc protein VCD_001274 ENOG4107QJR hflk protein VCD_001275 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) VCD_001276 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) VCD_001277 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) VCD_001278 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) VCD_001279 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase VCD_001280 ENOG4105K8N protein family UPF0079, ATPase VCD_001281 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) VCD_001282 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) VCD_001283 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) VCD_001284 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) VCD_001285 ENOG4105DJ4 phosphatidylserine decarboxylase VCD_001286 ENOG4107QWE )-transporter VCD_001288 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) VCD_001289 ENOG41063SB peptidase VCD_001291 ENOG41062JF Transcriptional regulator VCD_001292 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) VCD_001293 ENOG4105E09 nadh pyrophosphatase VCD_001294 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor VCD_001295 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) VCD_001296 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) VCD_001297 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) VCD_001298 ENOG4108VZM 50s ribosomal protein L10 VCD_001299 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) VCD_001300 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) VCD_001301 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) VCD_001302 ENOG4105PM1 preprotein translocase subunit SecE VCD_001303 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) VCD_001304 ENOG4105CS9 pantothenic acid kinase VCD_001305 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase VCD_001306 ENOG4105D4A Cell wall formation (By similarity) VCD_001308 ENOG4105JIM Phosphatidylserine synthase VCD_001310 ENOG4107QK7 reductase VCD_001312 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) VCD_001314 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) VCD_001315 ENOG4105K63 Thioredoxin VCD_001316 ENOG4105C1J atp-dependent rna helicase VCD_001317 ENOG4105C9X ppx gppa phosphatase VCD_001318 ENOG4105BZU Histidine kinase VCD_001319 ENOG4105D8G Major Facilitator superfamily VCD_001322 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) VCD_001323 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) VCD_001324 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein VCD_001325 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase VCD_001327 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) VCD_001329 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) VCD_001330 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) VCD_001331 ENOG4105DIQ Transcriptional regulator VCD_001332 ENOG4105C01 Dihydroxy-acid dehydratase VCD_001333 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family VCD_001334 ENOG4105C6Z Gluconate VCD_001335 ENOG4108UHU Aldolase VCD_001339 ENOG4105C8Q Methyl-accepting chemotaxis VCD_001340 ENOG4105CXN decarboxylase VCD_001341 ENOG4105D5Q Arginine ornithine antiporter VCD_001342 ENOG4108M3R transcriptional activator CadC VCD_001343 ENOG4105W1Y Transcriptional regulator VCD_001345 ENOG4105DC1 bifunctional purine biosynthesis protein purh VCD_001346 ENOG4105C12 Phosphoribosylglycinamide synthetase VCD_001348 ENOG4105K70 DNA-binding protein VCD_001351 ENOG4105DKQ ROK family VCD_001352 ENOG4105EIP mannose-6-phosphate isomerase VCD_001353 ENOG4105R2J Conserved Protein VCD_001354 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase VCD_001355 ENOG4108RG0 uracil-dna glycosylase VCD_001356 ENOG4105CUY Mechanosensitive ion channel VCD_001357 ENOG4105CY0 Metallo-Beta-Lactamase VCD_001359 ENOG4105D3Q Sugar transferase VCD_001367 ENOG4108EKI Dehydrogenase VCD_001368 ENOG4105CEY Amp-dependent synthetase and ligase VCD_001370 ENOG4105EY8 ABC transporter VCD_001373 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase VCD_001374 ENOG4105C0K Gdp-mannose 4,6-dehydratase VCD_001375 ENOG4107QKV phosphomannomutase VCD_001376 ENOG4105CJT Mannose-1-phosphate guanylyltransferase VCD_001377 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) VCD_001378 ENOG4107T94 Endo-14-beta-xylanase VCD_001381 ENOG4105XA0 heptosyltransferase ii VCD_001383 ENOG4108ST3 glycosyltransferase VCD_001384 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase VCD_001390 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) VCD_001391 ENOG4105DKP glycosyl transferase, family 9 VCD_001392 ENOG4106WTF Glycosyl transferase, family 2 VCD_001393 ENOG4105M5K heptosyltransferase VCD_001394 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) VCD_001395 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) VCD_001397 ENOG4105W0E 50S ribosomal protein L33 VCD_001398 ENOG4105KDC 50s ribosomal protein l28 VCD_001400 ENOG4105C8Q Methyl-accepting chemotaxis VCD_001401 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase VCD_001402 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) VCD_001403 ENOG4105D1S lipid A biosynthesis VCD_001404 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase VCD_001405 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) VCD_001406 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) VCD_001407 ENOG4105DSJ YicC domain protein VCD_001409 ENOG4105C5Y PTS System VCD_001410 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate VCD_001411 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) VCD_001412 ENOG4105S6R Iron-hydroxamate transporter permease subunit VCD_001413 ENOG4105J76 Periplasmic binding protein VCD_001414 ENOG4105E0A ABC, transporter VCD_001415 ENOG4105E0K tonB-dependent siderophore receptor VCD_001416 ENOG4105BZ1 (ABC) transporter VCD_001419 ENOG4105C9U ATP-dependent DNA helicase RecQ VCD_001420 ENOG4105FR1 rard protein VCD_001422 ENOG4108DMH HTH_ARAC VCD_001424 ENOG4105C4R Atp-dependent dna helicase VCD_001425 ENOG4105DGW oligopeptidase A VCD_001426 ENOG4105D6S protein involved in catabolism of external DNA VCD_001427 ENOG4105DC8 reductase VCD_001432 ENOG4108ZXE VCD_001435 ENOG4108UK2 deaminase VCD_001437 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VCD_001438 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component VCD_001439 ENOG4105DEF Extracellular solute-binding protein, family 5 VCD_001441 ENOG4105MPD Cytochrome VCD_001442 ENOG4105C4R Atp-dependent dna helicase VCD_001443 ENOG4105Y7M Transcriptional regulator, TetR family VCD_001444 ENOG410624X efflux transporter, rnd family, mfp subunit VCD_001445 ENOG4105BZS acriflavin resistance protein VCD_001446 ENOG4105W0Z cytoplasmic protein VCD_001447 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase VCD_001448 ENOG4105EMY transcriptional regulator VCD_001451 ENOG4108RR8 protoporphyrinogen oxidase VCD_001452 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) VCD_001453 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein VCD_001454 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase VCD_001455 ENOG4105CHU acetyl-coa acetyltransferase VCD_001456 ENOG4105F52 Transcriptional regulator VCD_001457 ENOG4105CZQ inner membrane transport protein YdhC VCD_001458 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) VCD_001459 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) VCD_001460 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) VCD_001461 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) VCD_001462 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) VCD_001463 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) VCD_001464 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) VCD_001465 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) VCD_001466 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) VCD_001467 ENOG410684E atp synthase VCD_001468 ENOG4105FA0 parb-like partition protein VCD_001469 ENOG4107QJE Chromosome Partitioning Protein VCD_001470 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) VCD_001471 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) VCD_001472 ENOG4105QTB Flavodoxin VCD_001473 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) VCD_001474 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins VCD_001475 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) VCD_001478 ENOG4105E5Q amino acid AbC transporter VCD_001479 ENOG4105EAB amino acid AbC transporter VCD_001480 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) VCD_001481 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) VCD_001482 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) VCD_001483 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) VCD_001486 ENOG4108ZNX Heat shock protein VCD_001487 ENOG4105JKW Valine--pyruvate aminotransferase VCD_001488 ENOG4105C38 Glycyl-tRNA synthetase beta subunit VCD_001489 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit VCD_001492 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) VCD_001494 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family VCD_001495 ENOG4105C7B Threonine dehydratase VCD_001496 ENOG4105C01 Dihydroxy-acid dehydratase VCD_001497 ENOG4105CM2 brancheD-chain amino acid aminotransferase VCD_001500 ENOG4105C0P Mg chelatase subunit ChlI VCD_001501 ENOG4106HNH Acyl-transferase VCD_001502 ENOG4108Z33 Thiol disulfide Interchange Protein VCD_001503 ENOG4105E27 serine threonine protein kinase VCD_001505 ENOG4105PC1 Conserved Protein VCD_001508 ENOG4108N23 SpoOM-related protein VCD_001509 ENOG4108UT2 hemolysin iii VCD_001511 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) VCD_001512 ENOG4105C1A potassium transporter peripheral membrane VCD_001513 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B VCD_001514 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) VCD_001516 ENOG4108WZM domain protein VCD_001517 ENOG4105C79 DNA protecting protein DprA VCD_001518 ENOG4108RPN Protein smg homolog VCD_001519 ENOG4108WI1 Dna topoisomerase VCD_001520 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit VCD_001521 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) VCD_001522 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) VCD_001523 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) VCD_001524 ENOG4105E2X shikimate dehydrogenase VCD_001526 ENOG4108Z0R Transferase VCD_001528 ENOG4105WMR Protein CrcB homolog VCD_001529 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) VCD_001531 ENOG4105D06 uba thif-type nad fad binding protein VCD_001532 ENOG4105WHD thiamine biosynthesis protein ThiS VCD_001533 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) VCD_001534 ENOG4105D41 biosynthesis protein thiH VCD_001535 ENOG4105DC7 peptidase M24 VCD_001535 ENOG4105DC7 peptidase M24 VCD_001537 ENOG4105CNH Multidrug resistance protein MdtL VCD_001539 ENOG4108VVK transcriptional Regulator, AsnC VCD_001540 ENOG4105BZU Histidine kinase VCD_001541 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) VCD_001543 ENOG4105EMK carboxylate amino acid amine transporter VCD_001544 ENOG4108M6U Universal stress protein A VCD_001545 ENOG41090A1 ferritin VCD_001546 ENOG4108V6B universal stress protein B VCD_001547 ENOG4105CBX hi0933 family VCD_001549 ENOG4105CGY Dna recombination protein VCD_001550 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) VCD_001551 ENOG4105JC1 sterol-binding domain protein VCD_001552 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) VCD_001553 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) VCD_001554 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) VCD_001555 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) VCD_001556 ENOG4105CA0 peroxidase VCD_001557 ENOG4107R73 Mate efflux family protein VCD_001559 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) VCD_001560 ENOG4105E55 glycerol-3-phosphate acyltransferase VCD_001561 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) VCD_001562 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) VCD_001563 ENOG4105X6C Flagellar basal body-associated protein FliL VCD_001564 ENOG4105C8Q Methyl-accepting chemotaxis VCD_001566 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) VCD_001567 ENOG4105F8V Hydrolase, tatD family VCD_001568 ENOG4105D52 delta-aminolevulinic acid dehydratase VCD_001570 ENOG4105C2M dna polymerase I VCD_001571 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) VCD_001572 ENOG4106RE7 Cytochrome VCD_001574 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) VCD_001575 ENOG4105XCT Protein of unknown function (DUF2489) VCD_001576 ENOG4105D4P Coproporphyrinogen iii oxidase VCD_001577 ENOG410601J HemY protein VCD_001578 ENOG4105ECF c-methyltransferase VCD_001579 ENOG41076E6 Uroporphyrinogen-III Synthase VCD_001580 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) VCD_001582 ENOG4107T0K Adenylate cyclase VCD_001583 ENOG4105XQ6 frataxin-like protein VCD_001585 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) VCD_001586 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) VCD_001587 ENOG4105CT0 Protein of unknown function, DUF484 VCD_001588 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) VCD_001589 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant VCD_001590 ENOG4105BZU Histidine kinase VCD_001593 ENOG4105DQF Hydrolase VCD_001594 ENOG4108EUD Lysophospholipase VCD_001595 ENOG410829K Lysine exporter protein (Lyse ygga) VCD_001596 ENOG4105D58 Diguanylate phosphodiesterase VCD_001597 ENOG4108RMU ferritin dps family protein VCD_001603 ENOG4106H78 methyltransferase VCD_001604 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) VCD_001605 ENOG4105CAK Cell division ATP-binding protein ftsE VCD_001606 ENOG4105CRP Part of the ABC transporter FtsEX involved in VCD_001607 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VCD_001608 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) VCD_001611 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) VCD_001612 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) VCD_001613 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin VCD_001614 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) VCD_001617 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) VCD_001618 ENOG4105BZU Histidine kinase VCD_001619 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VCD_001620 ENOG4105CUX Signal transduction histidine kinase VCD_001622 ENOG4105C5F glutamine synthetase VCD_001625 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) VCD_001627 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) VCD_001628 ENOG4105SUU thioesterase domain VCD_001630 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase VCD_001631 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) VCD_001632 ENOG4105VEJ Heat shock protein VCD_001633 ENOG4108XKW General secretion pathway protein C VCD_001635 ENOG4107QHF type ii secretion system protein e VCD_001636 ENOG4105D7Q type ii secretion system VCD_001637 ENOG4108VAU general secretion pathway protein G VCD_001638 ENOG4105VWV general secretion pathway protein h VCD_001639 ENOG4105X5Z General secretion pathway protein I VCD_001640 ENOG4108WWZ General secretion pathway protein J VCD_001641 ENOG4108RTD type II secretion system protein K VCD_001642 ENOG4108BY5 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) VCD_001643 ENOG4105U1E general secretion pathway protein M VCD_001644 ENOG4105PIC general secretion pathway protein N VCD_001645 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase VCD_001646 ENOG4107RK2 ADP-ribose diphosphatase NudE VCD_001647 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) VCD_001648 ENOG4105MJ2 Competence protein VCD_001649 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) VCD_001651 ENOG4105BZM domain protein VCD_001652 ENOG4108RRZ Transcription elongation factor GreB VCD_001653 ENOG4105DPZ Two component transcriptional regulator (Winged helix family VCD_001654 ENOG4105E0F Histidine kinase VCD_001655 ENOG4105C2W permease VCD_001656 ENOG4105CB5 ATP-dependent DNA helicase recG VCD_001657 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) VCD_001658 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) VCD_001659 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) VCD_001660 ENOG4105EX9 Membrane VCD_001661 ENOG4107QN1 sodium solute VCD_001663 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) VCD_001665 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) VCD_001669 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter VCD_001670 ENOG4108IJ0 Aspartate ammonia-lyase VCD_001671 ENOG4105BZU Histidine kinase VCD_001672 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 VCD_001673 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) VCD_001675 ENOG4105E0F Histidine kinase VCD_001676 ENOG4105E3W Two component transcriptional regulator (Winged helix family VCD_001678 ENOG41076HS cation diffusion facilitator family transporter VCD_001679 ENOG4105CTQ phosphohexokinase VCD_001680 ENOG4105CBT Fructose-1,6-bisphosphatase VCD_001681 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) VCD_001682 ENOG4105SYT Methylenetetrahydrofolate reductase VCD_001684 ENOG4105CFH Aspartokinase VCD_001685 ENOG4105C28 cystathionine VCD_001686 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) VCD_001687 ENOG4105C6K Malic enzyme VCD_001688 ENOG4105VFB Binds the 23S rRNA (By similarity) VCD_001689 ENOG4105C25 Primosomal protein n' VCD_001690 ENOG4105ETE Transcriptional regulator (LacI family VCD_001691 ENOG41063M6 Cell Division Protein VCD_001692 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) VCD_001693 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) VCD_001694 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase VCD_001695 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) VCD_001697 ENOG4105CP7 Triose-phosphate isomerase VCD_001702 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) VCD_001703 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) VCD_001705 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein VCD_001706 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) VCD_001707 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) VCD_001708 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) VCD_001709 ENOG4105E33 succinate dehydrogenase VCD_001711 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) VCD_001712 ENOG4107YZP Rhodanese domain protein VCD_001713 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) VCD_001714 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase VCD_001715 ENOG4105D7W serine acetyltransferase VCD_001717 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) VCD_001718 ENOG4105CWC Acetylornithine deacetylase VCD_001719 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase VCD_001720 ENOG4105CAS nag kinase VCD_001721 ENOG4105CDH Citrulline--aspartate ligase VCD_001723 ENOG4105CH7 arginosuccinase VCD_001725 ENOG4107QN2 dihydrolipoyl dehydrogenase VCD_001726 ENOG4105EHV domain protein VCD_001728 ENOG4108JQC penicillin-binding protein 1A VCD_001733 ENOG4105E4G Type IV pilus VCD_001734 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) VCD_001735 ENOG4105D49 3-dehydroquinate synthase VCD_001737 ENOG4105DFE Dna adenine methylase VCD_001738 ENOG4105DJV ribulose-phosphate 3-epimerase VCD_001739 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) VCD_001740 ENOG4105C31 Tryptophanyl-tRNA synthetase VCD_001743 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) VCD_001744 ENOG4105DDQ anthranilate synthase VCD_001745 ENOG4105C8Y Acetylornithine aminotransferase VCD_001747 ENOG4105C26 Dehydrogenase VCD_001749 ENOG4107RYR Transcriptional regulator, Crp Fnr family VCD_001750 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) VCD_001753 ENOG4105DNZ Alpha Beta Hydrolase VCD_001755 ENOG4105C5H ABC transporter VCD_001756 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein VCD_001759 ENOG4108YZY peptidylprolyl cis-trans isomerase VCD_001760 ENOG4105D44 asparaginase VCD_001761 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis VCD_001762 ENOG4108UV7 flagellar protein motX VCD_001763 ENOG4105E68 Sulfatase VCD_001764 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) VCD_001765 ENOG4105C2N RNA methyltransferase TrmH family group 3 VCD_001766 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) VCD_001767 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) VCD_001768 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) VCD_001769 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) VCD_001770 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity VCD_001771 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) VCD_001772 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) VCD_001773 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) VCD_001774 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) VCD_001775 ENOG41083MP 50s ribosomal protein l29 VCD_001776 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal VCD_001777 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) VCD_001778 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) VCD_001779 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits VCD_001780 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) VCD_001781 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) VCD_001782 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) VCD_001783 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) VCD_001784 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) VCD_001785 ENOG4105VPB 50S ribosomal protein L30 VCD_001786 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) VCD_001787 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) VCD_001789 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits VCD_001790 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) VCD_001791 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) VCD_001792 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) VCD_001793 ENOG4108ZT0 50S ribosomal protein l17 VCD_001795 ENOG4108V1T peptidylprolyl cis-trans isomerase VCD_001796 ENOG4108UBT opacity-associated protein VCD_001797 ENOG4108SXK Transporter Drug Metabolite Exporter family VCD_001798 ENOG4107YB6 acetyltransferase, (GNAT) family VCD_001799 ENOG4105C1J atp-dependent rna helicase VCD_001801 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic VCD_001802 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) VCD_001803 ENOG4105C11 sulfate adenylyltransferase), subunit 2 VCD_001804 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) VCD_001805 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) VCD_001809 ENOG4105C19 ABC transporter VCD_001812 ENOG4108UUE Transcriptional regulator VCD_001813 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) VCD_001814 ENOG4105CFU surface antigen VCD_001816 ENOG41066HZ AIG2-like family VCD_001817 ENOG4105F0N pyrophosphate phospho-hydrolase VCD_001818 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 VCD_001819 ENOG4105DFU Cell wall formation (By similarity) VCD_001820 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase VCD_001821 ENOG4105DP9 ABC transporter VCD_001822 ENOG4106SMU thiamine transporter membrane protein VCD_001823 ENOG4107T0D ABC, transporter VCD_001824 ENOG4105N42 UPF0307 protein VCD_001825 ENOG4105CMS peptidase U62, modulator of DNA gyrase VCD_001826 ENOG4105CJW magnesium transporter VCD_001827 ENOG41080Z8 PHOSPHOCARRIER protein VCD_001828 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) VCD_001829 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN VCD_001830 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA VCD_001831 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VCD_001832 ENOG4108IUZ ABC transporter VCD_001833 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA VCD_001835 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase VCD_001836 ENOG4105C2X Arabinose 5-phosphate isomerase VCD_001838 ENOG4105DHJ ABC, transporter VCD_001839 ENOG4105CY3 ABC transporter, permease VCD_001840 ENOG4107PE3 Mammalian cell entry related domain protein VCD_001841 ENOG4105E3I toluene tolerance VCD_001843 ENOG4105VFK BolA family VCD_001844 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) VCD_001845 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase VCD_001846 ENOG4105KME endoribonuclease L-psp VCD_001847 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) VCD_001848 ENOG4105CXT aspartate transcarbamylase VCD_001849 ENOG4105DBV ornithine carbamoyltransferase VCD_001850 ENOG4108IAB Phoh family VCD_001851 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) VCD_001852 ENOG4105D3G Pseudouridine synthase VCD_001853 ENOG4105C5I Dehydrogenase VCD_001854 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) VCD_001855 ENOG4105MYG DNA polymerase iii, chi subunit VCD_001856 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) VCD_001857 ENOG4108M8S permease YjgP YjgQ family protein VCD_001858 ENOG4108K5H permease YjgP YjgQ family protein VCD_001860 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase VCD_001863 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) VCD_001864 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) VCD_001865 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) VCD_001866 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) VCD_001871 ENOG41064T2 transcriptional regulator, lysR family VCD_001872 ENOG4108IQE Amp-dependent synthetase and ligase VCD_001873 ENOG4105C7K acetolactate synthase VCD_001874 ENOG4108ZP8 Acetolactate synthase small subunit VCD_001875 ENOG4108JQ1 Dehydrogenase VCD_001876 ENOG4105E66 phosphoriboisomerase A VCD_001877 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase VCD_001878 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) VCD_001880 ENOG4105D0A hydroxylase VCD_001881 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family VCD_001883 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) VCD_001884 ENOG4105Y75 tpr repeat protein VCD_001886 ENOG4108IYU L-aspartate oxidase VCD_001887 ENOG4105EMN RNA polymerase sigma factor VCD_001889 ENOG4105VQK sigma E regulatory protein, MucB RseB VCD_001890 ENOG4105WMJ Positive regulator of sigma E, RseC MucC VCD_001891 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) VCD_001892 ENOG4105C3F Signal peptidase i VCD_001893 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) VCD_001894 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) VCD_001895 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) VCD_001896 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) VCD_001897 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) VCD_001900 ENOG4108K0B C-di-gmp phosphodiesterase VCD_001901 ENOG4105BZU Histidine kinase VCD_001902 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) VCD_001903 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) VCD_001904 ENOG4105DXN mazG family VCD_001906 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) VCD_001907 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) VCD_001908 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate VCD_001911 ENOG4106MWK domain protein VCD_001912 ENOG4105CJ3 phosphate transporter VCD_001914 ENOG4107IX6 phosphate transport regulator VCD_001915 ENOG4105I7R Adenylate cyclase VCD_001916 ENOG4105C8Q Methyl-accepting chemotaxis VCD_001917 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) VCD_001919 ENOG4105DFG type I secretion outer membrane protein VCD_001920 ENOG41087AY ADP-Ribose pyrophosphatase VCD_001921 ENOG4108SX3 cytoplasmic protein VCD_001922 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) VCD_001923 ENOG4105IPS esterase VCD_001924 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) VCD_001925 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) VCD_001926 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) VCD_001927 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) VCD_001928 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) VCD_001929 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) VCD_001930 ENOG4105D7Q type ii secretion system VCD_001931 ENOG4107QHF type ii secretion system protein e VCD_001933 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase VCD_001935 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) VCD_001936 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) VCD_001937 ENOG4105T95 Thiol disulfide interChange protein VCD_001938 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) VCD_001939 ENOG4105CGH 5'-nucleotidase VCD_001940 ENOG41073TP transcriptional regulator VCD_001941 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) VCD_001942 ENOG4107QSN dihydrolipoamide acetyltransferase VCD_001943 ENOG4107QN2 dihydrolipoyl dehydrogenase VCD_001944 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) VCD_001945 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) VCD_001946 ENOG4105CJN penicillin-binding protein VCD_001947 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) VCD_001948 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) VCD_001949 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) VCD_001950 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) VCD_001952 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) VCD_001953 ENOG4105DFU Cell wall formation (By similarity) VCD_001954 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) VCD_001955 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) VCD_001956 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) VCD_001957 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) VCD_001959 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving VCD_001960 ENOG4105M6F mutator MutT protein VCD_001961 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) VCD_001962 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain VCD_001963 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain VCD_001966 ENOG4107RRE RNA-directed DNA polymerase VCD_001967 ENOG4105EJ9 Membrane VCD_001968 ENOG4105VP0 transcriptional regulator, lysR family VCD_001969 ENOG4105EN6 Membrane VCD_001970 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) VCD_001972 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) VCD_001974 ENOG4105BZ8 glutamate synthase VCD_001975 ENOG4105CBC glutamate synthase VCD_001978 ENOG4105N5T Radical SAM Protein VCD_001980 ENOG4105BZU Histidine kinase VCD_001981 ENOG41065U4 response regulator VCD_001983 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) VCD_001986 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) VCD_001987 ENOG4105D98 threonine synthase VCD_001988 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) VCD_001989 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) VCD_001990 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) VCD_001993 ENOG4105BZG amino acid carrier protein VCD_001996 ENOG4105EYA deoxyribonuclease VCD_001997 ENOG4105D9N nucleoside VCD_001998 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) VCD_001999 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) VCD_002000 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) VCD_002001 ENOG4105D3A purine nucleoside phosphorylase DeoD-type VCD_002003 ENOG4105EAC phosphoserine phosphatase VCD_002005 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) VCD_002006 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) VCD_002007 ENOG4108IQE Amp-dependent synthetase and ligase VCD_002008 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase VCD_002010 ENOG4105CNT hydrolase family 2 VCD_002011 ENOG41060NJ transcriptional regulator VCD_002012 ENOG4108Y51 tRNA-binding protein VCD_002016 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) VCD_002017 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) VCD_002019 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) VCD_002020 ENOG4105X2V dna damage-inducible protein VCD_002023 ENOG4105DSY exodeoxyribonuclease V, gamma VCD_002024 ENOG4107QKA exodeoxyribonuclease V beta VCD_002025 ENOG4107QYX exodeoxyribonuclease v alpha VCD_002027 ENOG4107QZM n-acetylglutamate synthase VCD_002031 ENOG4105CA3 membrane-bound lytic murein transglycosylase VCD_002032 ENOG4105CUZ uba thif-type nad fad binding protein VCD_002033 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) VCD_002034 ENOG4105C9B Cysteine desulfurase VCD_002035 ENOG4107S0N DJ-1 family VCD_002036 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) VCD_002037 ENOG4105DRB nucleoside-specific channel-forming protein VCD_002039 ENOG4105K6V RNA polymerase VCD_002041 ENOG4105EYM Major Facilitator superfamily VCD_002042 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) VCD_002044 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) VCD_002045 ENOG4105M85 Bola protein VCD_002046 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) VCD_002047 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) VCD_002048 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) VCD_002049 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) VCD_002050 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) VCD_002051 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) VCD_002052 ENOG4105CJ2 (LipO)protein VCD_002054 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) VCD_002058 ENOG4105C8J )-transporter VCD_002060 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) VCD_002061 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) VCD_002062 ENOG4105CIN aminoacyl-histidine dipeptidase VCD_002064 ENOG4105C7N Xanthine uracil vitamin C permease VCD_002065 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) VCD_002067 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) VCD_002068 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) VCD_002069 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) VCD_002070 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) VCD_002071 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) VCD_002074 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) VCD_002075 ENOG4107YIM Involved in the transcription termination process (By similarity) VCD_002076 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) VCD_002077 ENOG4108ZAI phosphatidylglycerophosphatase a VCD_002078 ENOG4108T8E UPF0325 protein VCD_002079 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) VCD_002080 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) VCD_002081 ENOG4105CE9 30S ribosomal protein S2 VCD_002082 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) VCD_002083 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) VCD_002084 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) VCD_002085 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) VCD_002086 ENOG4105KNE Phosphatidate cytidylyltransferase VCD_002087 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) VCD_002088 ENOG4105DZP Membrane-associated zinc metalloprotease VCD_002090 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) VCD_002091 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) VCD_002092 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) VCD_002093 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) VCD_002094 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) VCD_002095 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) VCD_002096 ENOG4105C0B DNA polymerase III (alpha subunit) VCD_002097 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) VCD_002098 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) VCD_002099 ENOG4105N7H Cytochrome VCD_002100 ENOG4105PY6 Phenolic acid decarboxylase VCD_002101 ENOG4108YZA Nitrogen regulatory protein pii VCD_002103 ENOG4105E9H Lytic Murein transglycosylase VCD_002104 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) VCD_002105 ENOG4105D1A Methyltransferase VCD_002106 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) VCD_002107 ENOG4108JDX DNA polymerase iii, epsilon subunit VCD_002109 ENOG4107QPN acyl-Coa dehydrogenase VCD_002110 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) VCD_002111 ENOG4105E7A Glutamine amidotransferase VCD_002112 ENOG4108V3E phosphoribosylglycinamide formyltransferase VCD_002113 ENOG4105CXB phosphoribosylaminoimidazole synthetase VCD_002114 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) VCD_002115 ENOG4105BZU Histidine kinase VCD_002116 ENOG4105FE9 pseudouridine synthase VCD_002117 ENOG4108DG9 Smr protein MutS2 VCD_002119 ENOG4105MBR gumn family VCD_002121 ENOG4105E2D ec 3.2.1.52 VCD_002123 ENOG4105C59 p-type ATPase VCD_002124 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) VCD_002125 ENOG4105UYK outer membrane protein a VCD_002127 ENOG4107RBR Receptor VCD_002128 ENOG4105Q26 Siderophore-interacting protein VCD_002129 ENOG4105C0W non-ribosomal peptide synthetase VCD_002136 ENOG4107R88 Chemotaxis protein (CheV) VCD_002137 ENOG4105BZU Histidine kinase VCD_002138 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) VCD_002139 ENOG4108ZC9 flagellar basal-body rod protein flgc VCD_002140 ENOG4105W00 Flagellar hook capping protein VCD_002141 ENOG4105BZE flagellar hook protein, FlgE VCD_002142 ENOG4108KPB Flagellar basal-body rod protein FlgF VCD_002143 ENOG4105CGA flagellar basal-body rod protein FlgG VCD_002144 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) VCD_002145 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) VCD_002146 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj VCD_002149 ENOG4105I03 Flagellin VCD_002150 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) VCD_002153 ENOG4105MEH VCD_002165 ENOG4105ED4 portal protein VCD_002191 ENOG4105I03 Flagellin VCD_002193 ENOG4105C3G gtp-binding protein VCD_002194 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) VCD_002195 ENOG4105C5T Phosphoribosyl pyrophosphate synthase VCD_002196 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) VCD_002197 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) VCD_002198 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) VCD_002199 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) VCD_002200 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) VCD_002201 ENOG4108YY7 Invasion gene expression up-regulator SirB VCD_002202 ENOG41063JG Transcriptional regulator VCD_002203 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase VCD_002204 ENOG4105CGH 5'-nucleotidase VCD_002205 ENOG4108Z66 YbaK ebsC protein VCD_002206 ENOG4105C2W permease VCD_002209 ENOG4105CS1 NAD(P)H quinone oxidoreductase VCD_002210 ENOG4105K89 arsenate reductase VCD_002211 ENOG4105ERG peptidase m48, ste24p VCD_002214 ENOG4105C8Q Methyl-accepting chemotaxis VCD_002215 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen VCD_002217 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) VCD_002218 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) VCD_002221 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) VCD_002222 ENOG4105KUZ arsenate reductase VCD_002225 ENOG4105QZU Inner membrane protein YfeZ VCD_002226 ENOG4105EZR dyp-type peroxidase family protein VCD_002227 ENOG4105I03 Flagellin VCD_002228 ENOG4105I03 Flagellin VCD_002229 ENOG4105I03 Flagellin VCD_002230 ENOG41063QE flagellar protein FlaG VCD_002231 ENOG4107W9T flagellar hook-associated VCD_002233 ENOG4105MQ3 flagellar protein FliS VCD_002234 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VCD_002235 ENOG4105BZU Histidine kinase VCD_002236 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VCD_002237 ENOG4105VQ0 flagellar hook-basal body complex protein fliE VCD_002238 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) VCD_002239 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) VCD_002240 ENOG4105W2B Flagellar assembly protein VCD_002241 ENOG4108JIR Flagellum-specific ATP synthase VCD_002244 ENOG4105X6C Flagellar basal body-associated protein FliL VCD_002245 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) VCD_002246 ENOG4105DD5 Flagellar motor switch protein VCD_002247 ENOG4105VTB flagellar biosynthesis protein fliO VCD_002248 ENOG4105CN7 Flagellar biosynthetic protein FliP VCD_002249 ENOG4105VS8 Flagellar biosynthetic protein fliq VCD_002250 ENOG4105D19 Role in flagellar biosynthesis (By similarity) VCD_002251 ENOG4105D00 flagellar biosynthetic protein flhB VCD_002253 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) VCD_002254 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase VCD_002255 ENOG4105EN6 Membrane VCD_002256 ENOG4108BPE -transporting atpase VCD_002257 ENOG4105MH2 YfcL protein VCD_002258 ENOG4105Q8W reductase VCD_002259 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) VCD_002260 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) VCD_002261 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) VCD_002262 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) VCD_002263 ENOG41090R7 Ferric uptake VCD_002265 ENOG4105CMU LysR family (Transcriptional regulator VCD_002266 ENOG4105VAW lrga family VCD_002267 ENOG41067MG lrgb family VCD_002268 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) VCD_002270 ENOG4105EV9 Alpha Beta Hydrolase VCD_002271 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) VCD_002272 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 VCD_002274 ENOG4107QNR UPF0135 protein VCD_002275 ENOG4105BZN citrate synthase VCD_002276 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit VCD_002277 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein VCD_002278 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) VCD_002279 ENOG4105E33 succinate dehydrogenase VCD_002280 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 VCD_002281 ENOG4105C7S Dehydrogenase VCD_002282 ENOG4105CMV Succinyl-CoA synthetase subunit beta VCD_002283 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha VCD_002284 ENOG4105FAV ABC, transporter VCD_002285 ENOG4105FDK ABC transporter VCD_002286 ENOG4105NXV High-affinity zinc uptake system protein VCD_002287 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) VCD_002289 ENOG4105XFK Ferrous iron transport protein A VCD_002293 ENOG4105C75 arginyL-tRNA synthetase VCD_002295 ENOG4108JQM Insulinase (Peptidase family M16) VCD_002296 ENOG4108BY2 phosphohistidine phosphatase VCD_002297 ENOG4105D7B Flagellar biosynthesis protein flha VCD_002298 ENOG4105FZW flagellar biosynthesis regulator FlhF VCD_002299 ENOG4107R21 site-determining protein VCD_002300 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VCD_002301 ENOG4108VYJ response regulator receiver protein VCD_002302 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) VCD_002303 ENOG4105CBS Chea signal transduction histidine kinase VCD_002304 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) VCD_002305 ENOG4107QJE Chromosome Partitioning Protein VCD_002307 ENOG4108V3W Chemotaxis protein, CheW VCD_002309 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) VCD_002310 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) VCD_002311 ENOG41060IM Heme exporter protein VCD_002312 ENOG41067VX Heme exporter protein VCD_002313 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) VCD_002314 ENOG4105DA4 cytochrome c-type biogenesis protein VCD_002315 ENOG4107QX9 Thiol disulfide interChange protein VCD_002316 ENOG4105KWW Biogenesis protein VCD_002318 ENOG410903C (LipO)protein VCD_002322 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) VCD_002323 ENOG4105M2J Glutaredoxin VCD_002324 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) VCD_002325 ENOG4105DGU Histone deacetylase VCD_002326 ENOG4105E68 Sulfatase VCD_002328 ENOG4106V8H Nucleoid-associated protein VCD_002330 ENOG4105DFD Na H antiporter VCD_002331 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) VCD_002332 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein VCD_002334 ENOG4108EKI Dehydrogenase VCD_002336 ENOG4105CHH sulfate transporter VCD_002337 ENOG4105C03 ribonuclease VCD_002339 ENOG4105EI2 Pseudouridine synthase VCD_002340 ENOG4108UHJ MAF-like protein VCD_002341 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein VCD_002342 ENOG4105VGS 50s ribosomal protein l32 VCD_002343 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) VCD_002344 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) VCD_002345 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase VCD_002346 ENOG4105CHR reductase VCD_002347 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) VCD_002348 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) VCD_002349 ENOG4105YAZ 4-amino-4-deoxychorismate lyase VCD_002350 ENOG4105HHA aminodeoxychorismate lyase VCD_002351 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) VCD_002352 ENOG4107QRG dna polymerase iii VCD_002353 ENOG4105F8V Hydrolase, tatD family VCD_002354 ENOG4105CI1 PTS System VCD_002355 ENOG4105C8J )-transporter VCD_002358 ENOG4108NRW Phospholipase, patatin family VCD_002359 ENOG4105CA9 Pyruvate kinase VCD_002360 ENOG4105DAG ROK family VCD_002361 ENOG4107R88 Chemotaxis protein (CheV) VCD_002364 ENOG4105DHI Methyltransferase VCD_002366 ENOG4105DSB aldose 1-epimerase VCD_002367 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase VCD_002369 ENOG4105E0X reductase VCD_002372 ENOG4105VUT cytoplasmic protein VCD_002373 ENOG4105HDK L-asparaginase VCD_002374 ENOG4105D07 Signal peptide peptidase, SppA VCD_002375 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase VCD_002376 ENOG4105CIY formyltetrahydrofolate deformylase VCD_002378 ENOG4105DVT helicase VCD_002379 ENOG41072GX Peptidase M22 Glycoprotease VCD_002382 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) VCD_002383 ENOG4105CEY Amp-dependent synthetase and ligase VCD_002384 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) VCD_002388 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein VCD_002389 ENOG4105DK2 UPF0207 protein VCD_002390 ENOG4105CHM Aminotransferase VCD_002391 ENOG4105E4F Isochorismate synthase VCD_002392 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) VCD_002393 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) VCD_002394 ENOG4108IPT Naphthoate synthase VCD_002395 ENOG4105DNI Converts SHCHC to OSB (By similarity) VCD_002396 ENOG4105CEY Amp-dependent synthetase and ligase VCD_002397 ENOG4105DKK Benzoate VCD_002398 ENOG4108JCI Transcriptional regulator VCD_002399 ENOG4108N3W hemolysin secretion protein VCD_002400 ENOG4107S74 Lysophospholipid transporter LplT VCD_002405 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) VCD_002406 ENOG4107QMS site-determining protein VCD_002407 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) VCD_002408 ENOG4105VNG YcgL domain-containing protein VCD_002409 ENOG4105CVE Lytic murein transglycosylase VCD_002410 ENOG4105JQN Transcriptional regulator VCD_002411 ENOG4105D9N nucleoside VCD_002412 ENOG410662T chitinase VCD_002413 ENOG4105CUW cytochrome C-TYPE protein VCD_002414 ENOG4107QY8 reductase VCD_002416 ENOG4105JQN Transcriptional regulator VCD_002420 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) VCD_002427 ENOG4108HPI phosphatidate Cytidylyltransferase VCD_002429 ENOG4105BZU Histidine kinase VCD_002432 ENOG4105CNG UPF0061 protein VCD_002434 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit VCD_002435 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ VCD_002436 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VCD_002437 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VCD_002439 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation VCD_002440 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) VCD_002441 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) VCD_002442 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) VCD_002443 ENOG4105K70 DNA-binding protein VCD_002444 ENOG4105EIN peptidylprolyl cis-trans isomerase VCD_002445 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein VCD_002446 ENOG4105CAT Cytidine monophosphate kinase VCD_002447 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) VCD_002448 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) VCD_002449 ENOG4105Q4A inner membrane protein yciS VCD_002450 ENOG4105CFV Tetratricopeptide repeat protein VCD_002451 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) VCD_002452 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase VCD_002455 ENOG4107R11 Transcriptional regulator VCD_002457 ENOG4105DCF alanine dehydrogenase VCD_002458 ENOG4105EW9 transcriptional regulator AsnC family VCD_002459 ENOG4105CNU cell division protein FtsK VCD_002460 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) VCD_002461 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) VCD_002462 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) VCD_002464 ENOG4108NVR Methyl-accepting chemotaxis VCD_002465 ENOG4105K59 histidine triad (HIT) protein VCD_002471 ENOG4105CEP NADH dehydrogenase VCD_002473 ENOG4106M3D hemolysin VCD_002475 ENOG4108JA2 transcriptioN-repair coupling factor VCD_002477 ENOG4105D60 lipoprotein releasing system transmembrane protein VCD_002478 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) VCD_002479 ENOG4105D60 lipoprotein releasing system transmembrane protein VCD_002482 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 VCD_002483 ENOG4105BZ1 (ABC) transporter VCD_002485 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) VCD_002487 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) VCD_002488 ENOG4105ED1 spovr family VCD_002489 ENOG4106AKX UPF0229 protein VCD_002490 ENOG4105CYN Serine protein kinase VCD_002491 ENOG4105XWI UPF0304 protein VCD_002493 ENOG4105F1A Pyruvate formate-lyase VCD_002494 ENOG4108N3W hemolysin secretion protein VCD_002496 ENOG4105C6N Formate acetyltransferase VCD_002498 ENOG4108JEH abc transporter atp-binding protein VCD_002499 ENOG4105E89 ABC transporter VCD_002500 ENOG4105DSP amino acid AbC transporter VCD_002501 ENOG4106YG3 ABC transporter VCD_002502 ENOG4105CGK Exodeoxyribonuclease III VCD_002509 ENOG4105DZR Type I site-specific deoxyribonuclease VCD_002511 ENOG4105CVR type I restriction-modification system VCD_002514 ENOG4105CAF HipA N-terminal domain protein VCD_002517 ENOG4105C8Q Methyl-accepting chemotaxis VCD_002518 ENOG4106428 Protein of unknown function (DUF2496) VCD_002519 ENOG4108URS primosomal replication protein n'' VCD_002520 ENOG4105EJ9 Membrane VCD_002521 ENOG4105DVT helicase VCD_002522 ENOG4105ZU8 porin-like protein H VCD_002525 ENOG4105D58 Diguanylate phosphodiesterase VCD_002526 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) VCD_002527 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) VCD_002528 ENOG4105C8N cysteinyl-tRNA synthetase VCD_002529 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) VCD_002530 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) VCD_002531 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) VCD_002532 ENOG4105C4M (Ubiquinol oxidase) subunit I VCD_002533 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii VCD_002535 ENOG4105KJB cyd operon protein YbgE VCD_002537 ENOG4105E02 MotA TolQ exbB proton channel VCD_002538 ENOG4105M8F Biopolymer transport protein exbD tolR VCD_002540 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) VCD_002541 ENOG4105KCK Peptidoglycan-associated lipoprotein VCD_002543 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) VCD_002545 ENOG4105BZU Histidine kinase VCD_002546 ENOG4108RNS Exports L-alanine (By similarity) VCD_002547 ENOG4105EIP mannose-6-phosphate isomerase VCD_002548 ENOG4105DM4 PTS System VCD_002549 ENOG4106R3P AraC family transcriptional regulator VCD_002551 ENOG4108YRF PTS System VCD_002552 ENOG4105DM4 PTS System VCD_002553 ENOG4105DM4 PTS System VCD_002555 ENOG4105C26 Dehydrogenase VCD_002557 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family VCD_002558 ENOG4105VYA Uncharacterized conserved protein (DUF2132) VCD_002560 ENOG4105CVP deoxyribo-dipyrimidine photolyase VCD_002580 ENOG4108NYK Tape measure protein VCD_002585 ENOG4108YGG dna repair protein VCD_002587 ENOG4108478 ec 3.2.1.18 VCD_002588 ENOG4105CE4 GlcNAc 6-P deacetylase VCD_002589 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) VCD_002590 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) VCD_002591 ENOG4108ERU trap dicarboxylate transporter subunit DctP VCD_002592 ENOG41069H7 transport system small permease component VCD_002593 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VCD_002595 ENOG4105QEK Transcriptional regulator VCD_002596 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) VCD_002597 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) VCD_002601 ENOG4105CVR type I restriction-modification system VCD_002605 ENOG4105DZR Type I site-specific deoxyribonuclease VCD_002616 ENOG4105DZR Type I site-specific deoxyribonuclease VCD_002618 ENOG4105CVR type I restriction-modification system VCD_002621 ENOG4105CAF HipA N-terminal domain protein VCD_002624 ENOG4105C0D helicase VCD_002625 ENOG4105DFP Integrase VCD_002626 ENOG4105DFP Integrase VCD_002630 ENOG4105DY2 Paraquat-inducible protein b VCD_002631 ENOG4105F1S paraquat-inducible protein a VCD_002636 ENOG4108R86 Transcriptional regulator VCD_002637 ENOG4105C26 Dehydrogenase VCD_002638 ENOG4105MTM Protein of unknown function (DUF1496) VCD_002640 ENOG41067SE Tetr family transcriptional regulator VCD_002641 ENOG4107QPN acyl-Coa dehydrogenase VCD_002643 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) VCD_002644 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate VCD_002645 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) VCD_002647 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase VCD_002648 ENOG4105RKX Protein of unknown function (DUF2498) VCD_002649 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) VCD_002651 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) VCD_002652 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) VCD_002657 ENOG4105HP8 regulator of competence-specific genes VCD_002658 ENOG4105ETE Transcriptional regulator (LacI family VCD_002659 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) VCD_002660 ENOG4106WF9 DNA-binding transcriptional regulator TorR VCD_002661 ENOG4107S90 membrAne VCD_002662 ENOG4106371 Methyltransferase VCD_002663 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) VCD_002664 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) VCD_002665 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) VCD_002666 ENOG4105EW9 transcriptional regulator AsnC family VCD_002668 ENOG4105CCT upf0313 protein VCD_002669 ENOG4105BZU Histidine kinase VCD_002673 ENOG4105DZ2 Transcriptional regulator VCD_002674 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) VCD_002676 ENOG4105K9H YciI-like protein VCD_002677 ENOG4105NAU thioesterase Superfamily protein VCD_002678 ENOG4107835 probably involved in intracellular septation (By similarity) VCD_002680 ENOG4105GFG DUF218 domain VCD_002681 ENOG4108535 NAD dependent epimerase/dehydratase family VCD_002683 ENOG4105TMB Formate nitrite transporter VCD_002686 ENOG4107QY8 reductase VCD_002690 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase VCD_002693 ENOG4108JQ2 peptide transport system atp-binding protein VCD_002694 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein VCD_002695 ENOG4108EU3 peptide transport system, permease VCD_002696 ENOG4108I5W peptide transport system, permease protein VCD_002697 ENOG4108J59 Extracellular solute-binding protein, family 5 VCD_002698 ENOG4105E51 psp operon transcriptional activator VCD_002699 ENOG41087YS Phage shock protein A VCD_002702 ENOG4105C1P efflux transporter, rnd family, mfp subunit VCD_002705 ENOG4108R3E Dna-3-methyladenine glycosylase i VCD_002706 ENOG4105C28 cystathionine VCD_002707 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) VCD_002708 ENOG4105C8J )-transporter VCD_002710 ENOG4108W1A pseudouridine synthase VCD_002711 ENOG4108T9J Cdp-alcohol phosphatidyltransferase VCD_002712 ENOG4108VGW abc transporter atp-binding protein VCD_002713 ENOG4105CXZ ABC transporter, permease VCD_002714 ENOG4105VNH ABC transporter solute-binding protein VCD_002716 ENOG4105XZD Fe-S protein VCD_002718 ENOG4107QWP ABC-2 type transporter VCD_002719 ENOG4105CJ1 ABC, transporter VCD_002721 ENOG4105C44 Serine transporter VCD_002723 ENOG4105CJW magnesium transporter VCD_002724 ENOG4105BZU Histidine kinase VCD_002725 ENOG4105BZU Histidine kinase VCD_002727 ENOG4105KXC Collagenase VCD_002732 ENOG4108N3W hemolysin secretion protein VCD_002735 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) VCD_002739 ENOG4105CFI type iii restriction protein res subunit VCD_002740 ENOG4105I08 Pseudouridine synthase VCD_002741 ENOG4105C2C drug resistance transporter, Bcr CflA VCD_002743 ENOG4105CGD Nad-dependent epimerase dehydratase VCD_002744 ENOG4105UQX Mate efflux family protein VCD_002745 ENOG4108I0Y (ABC) transporter VCD_002748 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) VCD_002749 ENOG4105DY8 decarboxylase VCD_002750 ENOG4105E3Q saccharopine dehydrogenase VCD_002752 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) VCD_002753 ENOG4105CDV Ompa motb domain protein VCD_002754 ENOG4105DFG type I secretion outer membrane protein VCD_002759 ENOG4105F04 LysR family Transcriptional regulator VCD_002761 ENOG4108VKG metal-dependent hydrolase VCD_002762 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) VCD_002764 ENOG41090FY type IV pilus biogenesis stability protein PilW VCD_002765 ENOG4105CVG Homoserine O-transsuccinylase VCD_002769 ENOG4107V40 secretion protein, HlyD family VCD_002771 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism VCD_002772 ENOG4106YYS transcriptional regulatory protein VCD_002774 ENOG4107R88 Chemotaxis protein (CheV) VCD_002777 ENOG4105BZU Histidine kinase VCD_002780 ENOG4105F0Z galactose-1-phosphate uridylyltransferase VCD_002781 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) VCD_002782 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) VCD_002783 ENOG4106TD9 Diguanylate cyclase VCD_002784 ENOG4105BZU Histidine kinase VCD_002786 ENOG4105C7K acetolactate synthase VCD_002792 ENOG4105CH6 catalase VCD_002794 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) VCD_002796 ENOG4108TWJ NADH dehydrogenase subunit 5 VCD_002797 ENOG4105DUM transcriptional regulator, lysR family VCD_002798 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) VCD_002804 ENOG4105C9Q fumarate hydratase class II VCD_002806 ENOG4105C4M (Ubiquinol oxidase) subunit I VCD_002807 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii VCD_002808 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) VCD_002809 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) VCD_002810 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) VCD_002812 ENOG4107QZV Type I secretion membrane fusion protein VCD_002815 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) VCD_002817 ENOG4105CS2 ec 3.2.1.21 VCD_002818 ENOG4105DDV Transcriptional regulator (LacI family VCD_002819 ENOG4105M4H endoribonuclease L-psp VCD_002820 ENOG4105XEP YhcH YjgK YiaL family protein VCD_002821 ENOG4107VXM glycerophosphoryl diester phosphodiesterase VCD_002822 ENOG4105E98 transcriptional regulator DeoR family VCD_002823 ENOG4108IJ9 (ABC) transporter VCD_002824 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component VCD_002830 ENOG4109015 Biopolymer transport protein exbD tolR VCD_002831 ENOG41067XB TonB family VCD_002835 ENOG4107QI1 Mate efflux family protein VCD_002837 ENOG4105FGM Fructosamine kinase VCD_002839 ENOG4107TT5 NLP P60 protein VCD_002840 ENOG4105C8Q Methyl-accepting chemotaxis VCD_002843 ENOG4106IUH DTW domain containing protein VCD_002844 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) VCD_002848 ENOG4105CVM Molybdenum cofactor synthesis domain protein VCD_002849 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) VCD_002850 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) VCD_002851 ENOG4107A5B Binding-protein-dependent transport systems, inner membrane component VCD_002853 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VCD_002854 ENOG4105BZU Histidine kinase VCD_002855 ENOG4105C5H ABC transporter VCD_002856 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) VCD_002860 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) VCD_002862 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) VCD_002863 ENOG4105QAX Iron-sulfur VCD_002866 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) VCD_002868 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) VCD_002871 ENOG4105QNR S1 RNA binding domain protein VCD_002872 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B VCD_002873 ENOG4105DY2 Paraquat-inducible protein b VCD_002874 ENOG4105H2K paraquat-inducible protein a VCD_002875 ENOG4105BZ1 (ABC) transporter VCD_002876 ENOG4108ZGC gaf domain protein VCD_002877 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) VCD_002878 ENOG4105CN1 protease VCD_002880 ENOG4105CD8 aminopeptidase N VCD_002882 ENOG4105C7I Dehydrogenase VCD_002883 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) VCD_002884 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) VCD_002885 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) VCD_002887 ENOG4105C5H ABC transporter VCD_002890 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) VCD_002891 ENOG4105DAN ATP-dependent protease VCD_002892 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) VCD_002895 ENOG4105EUK rtx toxin RtxA VCD_002896 ENOG4108RC6 RTX toxin VCD_002901 ENOG4105BZU Histidine kinase VCD_002904 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i VCD_002907 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) VCD_002909 ENOG4105C59 p-type ATPase VCD_002912 ENOG4105DS0 Transcriptional regulator, Crp Fnr family VCD_002913 ENOG4105Q9Y Universal stress protein VCD_002914 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) VCD_002918 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) VCD_002919 ENOG4105F38 ABC transporter, permease VCD_002920 ENOG4105D38 putrescine abc transporter VCD_002921 ENOG4107RUE extracellular solute-binding protein family 1 VCD_002922 ENOG4107RUE extracellular solute-binding protein family 1 VCD_002925 ENOG4105BZG amino acid carrier protein VCD_002926 ENOG410829K Lysine exporter protein (Lyse ygga) VCD_002931 ENOG4105CS6 Rhs element vgr protein VCD_002932 ENOG4108WC9 type VI secretion system effector, hcp1 family VCD_002933 ENOG4105CTD carboxy-peptidase VCD_002934 ENOG4105C8Q Methyl-accepting chemotaxis VCD_002935 ENOG4105C0R drug resistance transporter emrb qaca subfamily VCD_002936 ENOG4105CW7 secretion protein, HlyD family VCD_002937 ENOG4105ENJ RND efflux system, outer membrane lipoprotein VCD_002939 ENOG4105C1J atp-dependent rna helicase VCD_002940 ENOG4107SDU Methyl-accepting chemotaxis VCD_002941 ENOG4108N3W hemolysin secretion protein VCD_002942 ENOG4105C8Q Methyl-accepting chemotaxis VCD_002943 ENOG4108V3W Chemotaxis protein, CheW VCD_002944 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) VCD_002946 ENOG4105BZU Histidine kinase VCD_002947 ENOG4105CBS Chea signal transduction histidine kinase VCD_002948 ENOG4105CBS Chea signal transduction histidine kinase VCD_002950 ENOG4108VYJ response regulator receiver protein VCD_002951 ENOG4108NVR Methyl-accepting chemotaxis VCD_002952 ENOG4105KPY Small multidrug resistance protein VCD_002953 ENOG4105CVP deoxyribo-dipyrimidine photolyase VCD_002954 ENOG4105C0R drug resistance transporter emrb qaca subfamily VCD_002955 ENOG4105EJC lysr family transcriptional regulator VCD_002957 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) VCD_002959 ENOG4105R8A Heat shock protein VCD_002961 ENOG4105CQ7 ATP-dependent helicase VCD_002965 ENOG4105BZU Histidine kinase VCD_002967 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB VCD_002968 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB VCD_002969 ENOG4105BZU Histidine kinase VCD_002971 ENOG4105BZU Histidine kinase VCD_002975 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) VCD_002976 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) VCD_002977 ENOG410667J hydrolase VCD_002979 ENOG4107QXX ABC transporter VCD_002980 ENOG4105EZ7 amino acid ABC transporter VCD_002981 ENOG4105DRP amino acid AbC transporter VCD_002982 ENOG4105CDA abc transporter atp-binding protein VCD_002983 ENOG4108MN8 Membrane VCD_002984 ENOG4108Z0T Part of a sulfur-relay system (By similarity) VCD_002985 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 VCD_002986 ENOG4105DR4 Methyltransferase VCD_002987 ENOG4106TD9 Diguanylate cyclase VCD_002990 ENOG4105BZU Histidine kinase VCD_002991 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase VCD_002992 ENOG4108RXX maleylacetoacetate isomerase VCD_002994 ENOG4105F1J Homogentisate 1,2-dioxygenase VCD_002995 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase VCD_002996 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) VCD_002999 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) VCD_003000 ENOG4105C7F AcnD-accessory protein PrpF VCD_003001 ENOG4108I0Z Aconitate hydratase VCD_003002 ENOG4105BZN citrate synthase VCD_003003 ENOG4105CR4 methylisocitrate lyase VCD_003004 ENOG41073TP transcriptional regulator VCD_003010 ENOG4107SDZ Galactoside transport system permease protein mglC VCD_003011 ENOG4105C2J ABC transporter VCD_003016 ENOG4107EXC regulatoR VCD_003017 ENOG4105EB3 Histidine kinase VCD_003018 ENOG4105RW8 MltA-interacting MipA family protein VCD_003019 ENOG4108MJ5 VirK protein VCD_003020 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VCD_003021 ENOG4105BZU Histidine kinase VCD_003022 ENOG4105C8P )-transporter VCD_003023 ENOG4108NVR Methyl-accepting chemotaxis VCD_003024 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) VCD_003027 ENOG4105D9U N-acetyltransferase VCD_003028 ENOG4108JU8 Transcriptional regulator VCD_003030 ENOG4105CM6 amino acid regulated cytosolic protein VCD_003033 ENOG4105CRQ synthase (Component I) VCD_003034 ENOG4105P8F nudix hydrolase VCD_003035 ENOG4105C44 Serine transporter VCD_003036 ENOG4105EJQ L-serine dehydratase VCD_003037 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase VCD_003044 ENOG4105DZR Type I site-specific deoxyribonuclease VCD_003046 ENOG4105CVR type I restriction-modification system VCD_003049 ENOG4105CAF HipA N-terminal domain protein VCD_003053 ENOG4108NVR Methyl-accepting chemotaxis VCD_003054 ENOG4105C5S asparaginyl-tRNA synthetase VCD_003056 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase VCD_003058 ENOG4105CGF Aromatic amino acid aminotransferase VCD_003061 ENOG4105C8Q Methyl-accepting chemotaxis VCD_003062 ENOG4105DJ9 glucan biosynthesis protein VCD_003063 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) VCD_003064 ENOG41060NJ transcriptional regulator VCD_003065 ENOG410901P UPF0249 protein VCD_003066 ENOG4105F8D glycoside hydrolase family 4 VCD_003067 ENOG4105VCP PTS System VCD_003069 ENOG4105VZJ PTS System VCD_003071 ENOG4105C94 Transporter VCD_003072 ENOG41067TZ transcriptional regulator, MarR family VCD_003076 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VCD_003078 ENOG4105CH5 extracellular solute-binding protein, family 7 VCD_003081 ENOG4105C5X domain protein VCD_003082 ENOG4105EAQ (twin-arginine translocation) pathway signal VCD_003083 ENOG4105DIT ErfK YbiS YcfS YnhG family protein VCD_003088 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) VCD_003090 ENOG4105S8Q sugar efflux transporter VCD_003092 ENOG4105C72 UPF0176 protein VCD_003093 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) VCD_003094 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) VCD_003095 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) VCD_003096 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) VCD_003097 ENOG4107QK7 reductase VCD_003102 ENOG4105C8Q Methyl-accepting chemotaxis VCD_003105 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) VCD_003106 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) VCD_003109 ENOG4108YZT Adenosylcobinamide kinase VCD_003110 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) VCD_003111 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) VCD_003113 ENOG4105E0X reductase VCD_003114 ENOG4108ETY sodium dicarboxylate symporter VCD_003115 ENOG4105CJB Exodeoxyribonuclease I VCD_003117 ENOG41067MG lrgb family VCD_003118 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) VCD_003121 ENOG4105FQ6 thiopurine methyltransferase VCD_003123 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) VCD_003125 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) VCD_003126 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) VCD_003128 ENOG4105BZU Histidine kinase VCD_003130 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) VCD_003131 ENOG4105WH1 Two component transcriptional regulator luxr family VCD_003132 ENOG4105CQ2 DNA polymerase VCD_003133 ENOG4105BZU Histidine kinase VCD_003135 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) VCD_003138 ENOG4105CZE histidine utilization repressor VCD_003139 ENOG4105CI2 imidazolone-5-propionate hydrolase VCD_003140 ENOG41088SP formiminoglutamate hydrolase VCD_003141 ENOG4105CGP Urocanate hydratase VCD_003142 ENOG4105C84 Histidine ammonia-lyase VCD_003144 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap VCD_003146 ENOG4105CQB FAD linked oxidase domain protein VCD_003149 ENOG4108ZG0 Ompa motb domain protein VCD_003153 ENOG4105C8V SAICAR synthetase VCD_003155 ENOG4107R1I NAD-dependent malic enzyme VCD_003157 ENOG4107GZ4 SanA protein VCD_003158 ENOG4105BZU Histidine kinase VCD_003159 ENOG4105C9B Cysteine desulfurase VCD_003161 ENOG4105C3M thioredoxin reductase VCD_003162 ENOG4108JJ9 ABC, transporter VCD_003163 ENOG4108JJ8 (ABC) transporter VCD_003164 ENOG4105FE9 pseudouridine synthase VCD_003165 ENOG4107RTD sua5 ycio yrdc ywlc family protein VCD_003166 ENOG4105DB7 PHP domain protein VCD_003169 ENOG4105CRQ synthase (Component I) VCD_003170 ENOG4105DDQ anthranilate synthase VCD_003171 ENOG4108I0Q anthranilate phosphoribosyltransferase VCD_003172 ENOG4105DK0 Indole-3-glycerol phosphate synthase VCD_003173 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) VCD_003174 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) VCD_003175 ENOG4105CK2 sodium dicarboxylate symporter VCD_003176 ENOG4107104 thymidine kinase VCD_003177 ENOG4105C9M aspartyl-trna synthetase VCD_003178 ENOG41081XQ Conserved Protein VCD_003179 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) VCD_003180 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) VCD_003181 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) VCD_003184 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) VCD_003186 ENOG4105CUX Signal transduction histidine kinase VCD_003191 ENOG4105DWU Membrane VCD_003193 ENOG4105DY8 decarboxylase VCD_003194 ENOG4106KNT transcriptional regulator VCD_003195 ENOG4108EKI Dehydrogenase VCD_003196 ENOG41090BQ Glutaredoxin VCD_003198 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit VCD_003199 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) VCD_003200 ENOG4105VEQ Cold shock protein VCD_003202 ENOG4108R99 pseudouridine synthase VCD_003203 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase VCD_003204 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) VCD_003205 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase VCD_003206 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) VCD_003207 ENOG4105ECC imidazole-glycerol-phosphate dehydratase VCD_003208 ENOG4105CIH Imidazole acetol-phosphate transaminase VCD_003209 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) VCD_003210 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) VCD_003211 ENOG4107S6Z Na H antiporter VCD_003213 ENOG4107RE1 Inosine-guanosine kinase VCD_003214 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) VCD_003215 ENOG41075W9 High frequency lysogenization protein HflD homolog VCD_003216 ENOG4107QTF adenylosuccinate lyase VCD_003218 ENOG4105RHG VCD_003220 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase VCD_003223 ENOG4107FW0 short-chain dehydrogenase reductase VCD_003225 ENOG4105D0M Protease HtpX homolog VCD_003227 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) VCD_003228 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) VCD_003229 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) VCD_003230 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) VCD_003231 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) VCD_003232 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) VCD_003233 ENOG4105D1H recombination factor protein RarA VCD_003235 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving VCD_003236 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) VCD_003237 ENOG4105BZU Histidine kinase VCD_003238 ENOG4108JJB ABC transporter VCD_003239 ENOG4105C7J ABC transporter, permease VCD_003241 ENOG4105VYA Uncharacterized conserved protein (DUF2132) VCD_003242 ENOG4105PQ6 UPF0208 membrane protein VCD_003243 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) VCD_003244 ENOG4108DNC Involved in acetate metabolism (By similarity) VCD_003245 ENOG4105CHF Glutathione S-transferase VCD_003246 ENOG4108JQ7 (ABC) transporter VCD_003247 ENOG4105C3U ABC transporter VCD_003248 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VCD_003249 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component VCD_003250 ENOG4107QSI ABC, transporter VCD_003253 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VCD_003254 ENOG4105BZU Histidine kinase VCD_003255 ENOG4105BZU Histidine kinase VCD_003256 ENOG4105BZU Histidine kinase VCD_003258 ENOG4107YTP response regulator receiver protein VCD_003261 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) VCD_003266 ENOG4108V1U phospholipid-binding protein VCD_003271 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase VCD_003272 ENOG41082YX Transcriptional regulator, arsr family VCD_003274 ENOG4105BZU Histidine kinase VCD_003279 ENOG4105C29 acyl-CoA thioesterase VCD_003280 ENOG4108XM1 transcriptional regulator AsnC family VCD_003282 ENOG4105ERU peptidase VCD_003283 ENOG4105UBK short-chain dehydrogenase reductase VCD_003285 ENOG4105KRS Proteinase inhibitor VCD_003286 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) VCD_003287 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) VCD_003288 ENOG4107QMP dna polymerase iii subunits gamma and tau VCD_003289 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) VCD_003290 ENOG4105WD1 Membrane VCD_003292 ENOG4105I93 response regulator VCD_003293 ENOG4105EJC lysr family transcriptional regulator VCD_003294 ENOG41069NU Nitroreductase VCD_003295 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase VCD_003296 ENOG4105CHU acetyl-coa acetyltransferase VCD_003299 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation VCD_003300 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation VCD_003302 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase VCD_003303 ENOG4108GAE asmA family VCD_003304 ENOG4105DBI uridine monophosphokinase VCD_003305 ENOG4105D1F ATP-binding protein VCD_003306 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) VCD_003308 ENOG4108I5U Uridine phosphorylase VCD_003311 ENOG4105BZU Histidine kinase VCD_003312 ENOG4108ZAF Molybdopterin VCD_003313 ENOG4105M00 molybdopterin converting factor, subunit 1 VCD_003314 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) VCD_003315 ENOG4108RIR Molybdenum cofactor biosynthesis protein VCD_003316 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) VCD_003317 ENOG4105CHW UPF0052 protein VCD_003319 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VCD_003320 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) VCD_003322 ENOG4108R3D Electron transport complex VCD_003324 ENOG4105D6A Electron transport complex VCD_003325 ENOG4108UQQ Electron transport complex VCD_003326 ENOG4105DZB Electron transport complex VCD_003327 ENOG4105CSM endonuclease III VCD_003328 ENOG4108UYE Lactoylglutathione lyase VCD_003329 ENOG4106WH9 Protein of unknown function (DUF2753) VCD_003330 ENOG4105EIY sodium-type flagellar protein motY VCD_003332 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) VCD_003333 ENOG4105D3Y Na H antiporter VCD_003334 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase VCD_003335 ENOG4105E96 Colicin v production protein VCD_003336 ENOG4108S3P Sporulation domain protein VCD_003337 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase VCD_003338 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) VCD_003339 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) VCD_003341 ENOG4105CX6 glutaminyL-tRNA synthetase VCD_003343 ENOG4105CI1 PTS System VCD_003344 ENOG4105CE4 GlcNAc 6-P deacetylase VCD_003345 ENOG4105E2R ROK family VCD_003346 ENOG4105CKD glutathione-regulated potassium-efflux system protein VCD_003347 ENOG4105CAQ asparagine synthetase VCD_003348 ENOG4105MDZ Transcriptional activator rfaH VCD_003349 ENOG4105DUX Transporter VCD_003351 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) VCD_003352 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) VCD_003353 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) VCD_003354 ENOG4108TU9 TRANSCRIPTIONal VCD_003357 ENOG4108RE9 Phosphodiesterase VCD_003358 ENOG4105ECP epimerase VCD_003359 ENOG4105E1F short-chain dehydrogenase reductase VCD_003361 ENOG4107QR8 Thioredoxin VCD_003362 ENOG4107QX8 SPFH domain, Band 7 family protein VCD_003363 ENOG4105G5H Membrane VCD_003364 ENOG4108Z6Z Transcriptional regulator VCD_003366 ENOG41081QG Porin Gram-negative type VCD_003367 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) VCD_003368 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) VCD_003369 ENOG4105EXN Sulfate transport protein CysZ VCD_003370 ENOG4105C6T cysteine synthase VCD_003371 ENOG4105KZ7 phosphocarrier protein hpr VCD_003373 ENOG4105C5Y PTS System VCD_003374 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family VCD_003375 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) VCD_003376 ENOG4105C9A Phoh family VCD_003377 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) VCD_003378 ENOG4108JU5 Magnesium and cobalt efflux protein VCD_003379 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) VCD_003380 ENOG4107PAI alpha helical protein VCD_003381 ENOG4105C8T Leucyl-tRNA synthetase VCD_003382 ENOG4108U2H Rare lipoprotein B VCD_003383 ENOG4105DJF DNA polymerase III, delta' subunit VCD_003384 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) VCD_003385 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) VCD_003386 ENOG4105CJN penicillin-binding protein VCD_003387 ENOG4105CNI cell division protein FtsW VCD_003388 ENOG4105K6T rare lipoprotein A VCD_003389 ENOG4105DZ1 carboxypeptidase VCD_003390 ENOG4108Z43 UPF0250 protein VCD_003391 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) VCD_003392 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) VCD_003394 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) VCD_003398 ENOG4105D75 Capsular exopolysaccharide family VCD_003399 ENOG4105DAY polysaccharide export protein VCD_003401 ENOG4105D3Q Sugar transferase VCD_003404 ENOG4108MA4 Peptidase M66 VCD_003407 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family VCD_003409 ENOG4105Q84 sucrose synthase VCD_003411 ENOG4105D7W serine acetyltransferase VCD_003415 ENOG4108UW5 maltose o-acetyltransferase VCD_003417 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase VCD_003418 ENOG4107ZF2 Phosphatase VCD_003419 ENOG4105BZS acriflavin resistance protein VCD_003421 ENOG4105CG3 alpha amylase, catalytic region VCD_003422 ENOG4105C5Y PTS System VCD_003423 ENOG4105D4X repressor VCD_003424 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase VCD_003425 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) VCD_003426 ENOG4108UMI ABC transporter, permease VCD_003427 ENOG4105D01 (LipO)protein VCD_003428 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein VCD_003429 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) VCD_003430 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) VCD_003432 ENOG4105BZU Histidine kinase VCD_003433 ENOG4105EWT decarboxylase family VCD_003434 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease VCD_003435 ENOG4105M08 Membrane VCD_003436 ENOG4105ETT transcriptional Regulator, LysR family VCD_003437 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) VCD_003439 ENOG4106VK6 Flagellar motor protein VCD_003440 ENOG4105E14 MotA TolQ exbB proton channel VCD_003442 ENOG4105CTB Polyprenyl synthetase VCD_003443 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) VCD_003444 ENOG4105DR9 pseudouridine synthase VCD_003445 ENOG4105WP7 tRNA pseudouridine synthase C VCD_003448 ENOG4108428 Inherit from COG: -acetyltransferase VCD_003450 ENOG4108UPT UPF0178 protein VCD_003451 ENOG4105CFC Transporter VCD_003453 ENOG4105NRA 50s ribosomal protein l31 type b VCD_003454 ENOG4108R96 Methyltransferase, YaeB family VCD_003455 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) VCD_003459 ENOG4108RS6 transposase VCD_003460 ENOG4107QIK phosphoribosylformylglycinamidine synthase VCD_003462 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) VCD_003463 ENOG4108Z6B deaminase VCD_003464 ENOG4105CFC Transporter VCD_003471 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) VCD_003472 ENOG4105CFG Acts as a chaperone (By similarity) VCD_003474 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ VCD_003475 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) VCD_003476 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) VCD_003477 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) VCD_003478 ENOG4105VDB UPF0125 protein VCD_003479 ENOG4108Z1B Cyclase dehydrase VCD_003480 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) VCD_003484 ENOG4105F88 accessory colonization factor AcfD VCD_003486 ENOG4105DR5 peptidase VCD_003488 ENOG4105C8Q Methyl-accepting chemotaxis VCD_003489 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) VCD_003492 ENOG4108VEY type ii secretion system VCD_003493 ENOG4107QHF type ii secretion system protein e VCD_003497 ENOG4105GRU toxin co-regulated pilus biosynthesis outer membrane protein C VCD_003500 ENOG4105XB6 Toxin coregulated pilin VCD_003503 ENOG4107RK6 Methyl-accepting chemotaxis VCD_003504 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) VCD_003508 ENOG4105C26 Dehydrogenase VCD_003519 ENOG4105DZ0 fad dependent oxidoreductase VCD_003521 ENOG4108Z4U Ferredoxin VCD_003524 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase VCD_003525 ENOG4105YGP holo-ACP synthase CitX VCD_003526 ENOG4105CHY citrate lyase, alpha VCD_003527 ENOG4105CI0 Citrate lyase VCD_003528 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) VCD_003529 ENOG4105DUA (citrate (pro-3S)-lyase ligase VCD_003532 ENOG4107QSA Oxaloacetate decarboxylase VCD_003533 ENOG4105D9Q decarboxylase (Beta subunit) VCD_003534 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism VCD_003536 ENOG4106YYS transcriptional regulatory protein VCD_003540 ENOG4105MWK D-amino acid dehydrogenase, small subunit VCD_003542 ENOG4105BZG amino acid carrier protein VCD_003543 ENOG4105EUZ Beta-lactamase domain protein VCD_003544 ENOG41064T2 transcriptional regulator, lysR family VCD_003546 ENOG4105E0A ABC, transporter VCD_003548 ENOG4105TVJ transport system, permease VCD_003549 ENOG4105DQ5 transport system permease protein VCD_003550 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein VCD_003552 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase VCD_003553 ENOG4105E4F Isochorismate synthase VCD_003554 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase VCD_003555 ENOG4105WQI isochorismatase VCD_003556 ENOG4106HK8 GPR1 FUN34 yaaH family protein VCD_003558 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) VCD_003559 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) VCD_003560 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) VCD_003563 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) VCD_003564 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) VCD_003565 ENOG4105N21 Membrane VCD_003566 ENOG4105CUT histidyl-tRNA synthetase VCD_003567 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) VCD_003569 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs VCD_003570 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) VCD_003571 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) VCD_003572 ENOG4105WVQ Fe-S assembly protein IscX VCD_003573 ENOG4108ZIT Ferredoxin, 2FE-2S VCD_003574 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB VCD_003575 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) VCD_003576 ENOG4108Z4V iron-sulfur cluster assembly VCD_003577 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins VCD_003578 ENOG4105C3J Cysteine desulfurase VCD_003579 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family VCD_003580 ENOG4105CVS RNA methyltransferase TrmH family, group 1 VCD_003581 ENOG4105ECY inositol monophosphatase VCD_003582 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) VCD_003583 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) VCD_003584 ENOG4105VIE preprotein translocase, subunit YajC VCD_003585 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) VCD_003586 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) VCD_003588 ENOG4105W87 Cbs domain VCD_003589 ENOG4108I9X Isocitrate lyase VCD_003591 ENOG4107QP3 malate synthase g VCD_003592 ENOG4105C5Q Transcriptional regulator VCD_003593 ENOG4105D3R alkyl hydroperoxide reductase VCD_003594 ENOG4106N3A copper homeostasis protein cutc VCD_003596 ENOG4105CSR polyphosphate kinase 2 VCD_003598 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) VCD_003599 ENOG4105E2Z phosphate ABC transporter (Permease VCD_003600 ENOG4105C8U phosphate abc transporter VCD_003601 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) VCD_003602 ENOG4105C9X ppx gppa phosphatase VCD_003604 ENOG4105BZU Histidine kinase VCD_003605 ENOG4105CK6 Two component transcriptional regulator (Winged helix family VCD_003606 ENOG4105DH7 May be involved in recombination (By similarity) VCD_003607 ENOG4105CFP Peptidase U32 VCD_003608 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding VCD_003611 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit VCD_003612 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase VCD_003613 ENOG4105C34 Pseudouridine synthase VCD_003614 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane VCD_003616 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA VCD_003618 ENOG4107XW0 Spermidine putrescine ABC transporter periplasmic spermidine putrescine-binding protein VCD_003619 ENOG4108K0B C-di-gmp phosphodiesterase VCD_003620 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) VCD_003621 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) VCD_003622 ENOG4107SC1 transglycosylase VCD_003623 ENOG4105C5H ABC transporter VCD_003626 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) VCD_003627 ENOG4108HRK Histidine kinase VCD_003628 ENOG4108NEV two component transcriptional regulator, LytTR family VCD_003629 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) VCD_003630 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) VCD_003631 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate VCD_003635 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) VCD_003636 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase VCD_003637 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) VCD_003638 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) VCD_003639 ENOG4105DTN riboflavin biosynthesis protein ribF VCD_003640 ENOG4105CJR Integral membrane protein (MviN VCD_003641 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) VCD_003642 ENOG41080HT Transcriptional regulator, arsr family VCD_003643 ENOG41063Z6 transcriptional regulator, lysR family VCD_003646 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) VCD_003647 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) VCD_003648 ENOG4105HF0 Membrane VCD_003649 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase VCD_003650 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) VCD_003651 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) VCD_003652 ENOG4105CPC Aldo Keto reductase VCD_003654 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VCD_003655 ENOG4105CRK lysyL-tRNA synthetase VCD_003656 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) VCD_003657 ENOG4105CWM branched-chain amino acid transport system II carrier protein VCD_003658 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) VCD_003659 ENOG4105C1J atp-dependent rna helicase VCD_003660 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) VCD_003673 ENOG4108KB1 transcriptional regulator, arac family VCD_003677 ENOG4108YGG dna repair protein VCD_003682 ENOG4105GMT ATPase associated with various cellular activities aaa_5 VCD_003686 ENOG4108UUM single-stranded DNA-binding protein VCD_003697 ENOG4105T95 Thiol disulfide interChange protein VCD_003698 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VCD_003715 ENOG4105ESI atpase involved in dna repair VCD_003726 ENOG4105KT5 UmuD protein VCD_003731 ENOG4108R0M Aminoglycoside VCD_003734 ENOG4105PGM cation diffusion facilitator family transporter VCD_003736 ENOG4108R0M Aminoglycoside VCD_003745 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) VCD_003752 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) VCD_003753 ENOG4105BZU Histidine kinase VCD_003756 ENOG4108YYD acetyltransferase VCD_003757 ENOG4105XPQ lipid carrier protein VCD_003758 ENOG4105BZU Histidine kinase VCD_003759 ENOG4105CFP Peptidase U32 VCD_003760 ENOG4106RZ4 Peptidase U32 VCD_003763 ENOG4105RT1 May be involved in cell division (By similarity) VCD_003764 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) VCD_003765 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) VCD_003766 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) VCD_003767 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) VCD_003768 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) VCD_003769 ENOG4105CHV Transcription elongation factor NusA VCD_003770 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) VCD_003772 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) VCD_003773 ENOG4105EEI dihydropteroate synthase VCD_003774 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) VCD_003775 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) VCD_003776 ENOG4105HBR Rna-binding protein VCD_003777 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) VCD_003778 ENOG4105FCK Membrane VCD_003779 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase VCD_003780 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) VCD_003781 ENOG4105DR5 peptidase VCD_003784 ENOG4108YX9 iron--sulfur cluster insertion protein erpA VCD_003785 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase VCD_003786 ENOG4105IPI Membrane VCD_003787 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) VCD_003788 ENOG4105BZU Histidine kinase VCD_003789 ENOG4107QRA Extracellular solute-binding protein, family 5 VCD_003791 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VCD_003792 ENOG4105C3U ABC transporter VCD_003793 ENOG4108JQ7 (ABC) transporter VCD_003795 ENOG4105RD7 BadF BadG BcrA BcrD VCD_003796 ENOG4105E2D ec 3.2.1.52 VCD_003797 ENOG4105E2V Glycosyltransferase 36 VCD_003799 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) VCD_003803 ENOG4108YZA Nitrogen regulatory protein pii VCD_003804 ENOG4105XTV UPF0231 protein VCD_003805 ENOG4107QIJ Aconitate hydratase 2 VCD_003806 ENOG4105D78 K07001 NTE family protein VCD_003807 ENOG4105BZ4 penicillin-binding protein VCD_003808 ENOG4105CQ7 ATP-dependent helicase VCD_003810 ENOG4105PW4 Sugar fermentation stimulation protein homolog VCD_003811 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters VCD_003812 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) VCD_003813 ENOG4105DJ0 Poly(A) Polymerase VCD_003814 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase