locus-tag	class	description
VCD_000004	COG0366	Alpha amylase catalytic
VCD_000005	COG3038	cytochrome b561
VCD_000011	COG0561	phosphatase activity
VCD_000012	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
VCD_000013	COG3623	hexulose-6-phosphate isomerase
VCD_000016	COG0745	RESPONSE REGULATOR receiver
VCD_000020	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VCD_000024	COG4604	ABC transporter, ATP-binding protein
VCD_000025	COG4605	iron ion homeostasis
VCD_000026	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VCD_000030	COG4412	M6 family metalloprotease domain protein
VCD_000030	COG3291	Pkd domain containing protein
VCD_000031	COG5380	lipid catabolic process
VCD_000032	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
VCD_000033	COG0840	transmembrane signaling receptor activity
VCD_000035	COG3240	lipase activity
VCD_000036	COG3706	GGDEF domain
VCD_000039	COG2814	Major facilitator Superfamily
VCD_000040	COG1757	Na H antiporter
VCD_000042	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VCD_000042	COG4191	Histidine kinase
VCD_000043	COG3437	response regulator, receiver
VCD_000043	COG0784	Response regulator, receiver
VCD_000044	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VCD_000045	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VCD_000046	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VCD_000047	COG0513	Belongs to the DEAD box helicase family
VCD_000048	COG1943	Transposase
VCD_000053	COG0516	GMP reductase activity
VCD_000055	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VCD_000057	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VCD_000058	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
VCD_000058	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
VCD_000064	COG3036	rescue of stalled ribosome
VCD_000065	COG1278	Cold shock
VCD_000066	COG1017	nitric oxide dioxygenase activity
VCD_000066	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VCD_000067	COG3604	Transcriptional regulator
VCD_000070	COG2195	Cleaves the N-terminal amino acid of tripeptides
VCD_000071	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VCD_000074	COG0840	transmembrane signaling receptor activity
VCD_000075	COG0714	Associated with various cellular activities
VCD_000079	COG2304	oxidoreductase activity
VCD_000082	COG1278	Cold shock
VCD_000083	COG5001	Diguanylate cyclase
VCD_000083	COG5002	protein histidine kinase activity
VCD_000085	COG3530	Putative quorum-sensing-regulated virulence factor
VCD_000086	COG3033	Beta-eliminating lyase
VCD_000087	COG0814	amino acid
VCD_000088	COG0589	response to stress
VCD_000090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VCD_000090	COG2111	Na H antiporter
VCD_000094	COG2212	antiporter activity
VCD_000095	COG1320	monovalent cation:proton antiporter activity
VCD_000097	COG0242	peptide deformylase activity
VCD_000100	COG0579	oxidoreductase
VCD_000108	COG2271	Major facilitator Superfamily
VCD_000109	COG0584	glycerophosphoryl diester phosphodiesterase
VCD_000111	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VCD_000114	COG1609	Transcriptional regulator
VCD_000115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VCD_000116	COG1879	ABC-type sugar transport system periplasmic component
VCD_000117	COG1172	Belongs to the binding-protein-dependent transport system permease family
VCD_000118	COG1129	ABC transporter
VCD_000119	COG1869	D-ribose catabolic process
VCD_000122	COG3501	Rhs element vgr protein
VCD_000140	COG0564	pseudouridine synthase activity
VCD_000142	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VCD_000143	COG2771	luxR family
VCD_000143	COG2200	EAL domain
VCD_000145	COG0673	inositol 2-dehydrogenase activity
VCD_000146	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
VCD_000151	COG1342	Belongs to the UPF0251 family
VCD_000153	COG1301	dicarboxylic acid transport
VCD_000158	COG2814	Major facilitator Superfamily
VCD_000159	COG0583	DNA-binding transcription factor activity
VCD_000160	COG3300	MHYT domain
VCD_000160	COG5001	Diguanylate cyclase
VCD_000161	COG0739	heme binding
VCD_000163	COG0659	secondary active sulfate transmembrane transporter activity
VCD_000167	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VCD_000168	COG0581	inorganic phosphate transmembrane transporter activity
VCD_000169	COG0573	inorganic phosphate transmembrane transporter activity
VCD_000170	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VCD_000176	COG1770	oligopeptidase
VCD_000177	COG0513	Belongs to the DEAD box helicase family
VCD_000180	COG1376	ErfK ybiS ycfS ynhG family protein
VCD_000180	COG1388	LysM domain
VCD_000181	COG0415	Belongs to the DNA photolyase family
VCD_000183	COG3272	Protein of unknown function (DUF1722)
VCD_000184	COG0813	purine-nucleoside phosphorylase activity
VCD_000187	COG3706	GGDEF domain
VCD_000189	COG1566	PFAM secretion protein HlyD family protein
VCD_000193	COG0786	glutamate:sodium symporter activity
VCD_000196	COG1999	signal sequence binding
VCD_000198	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
VCD_000199	COG0671	phosphoesterase, PA-phosphatase related
VCD_000207	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VCD_000208	COG0471	metal ion transport
VCD_000215	COG3501	Rhs element vgr protein
VCD_000217	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VCD_000218	COG1640	4-alpha-glucanotransferase
VCD_000219	COG0058	SHG alpha-glucan phosphorylase activity
VCD_000220	COG2909	trisaccharide binding
VCD_000223	COG2084	Dehydrogenase
VCD_000224	COG0217	transcriptional regulatory protein
VCD_000231	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VCD_000232	COG1444	tRNA N-acetyltransferase activity
VCD_000238	COG0745	RESPONSE REGULATOR receiver
VCD_000239	COG0642	Histidine kinase
VCD_000241	COG2194	sulfuric ester hydrolase activity
VCD_000243	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VCD_000244	COG0601	transmembrane transport
VCD_000248	COG2198	Histidine kinase
VCD_000248	COG0643	Histidine kinase
VCD_000249	COG0835	chemotaxis
VCD_000250	COG0835	chemotaxis
VCD_000251	COG0840	transmembrane signaling receptor activity
VCD_000252	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VCD_000253	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
VCD_000257	COG0745	RESPONSE REGULATOR receiver
VCD_000263	COG0259	pyridoxamine-phosphate oxidase activity
VCD_000265	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VCD_000271	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VCD_000277	COG1982	Orn Lys Arg decarboxylase major
VCD_000278	COG0531	amino acid
VCD_000280	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VCD_000281	COG1901	pseudouridine methyltransferase
VCD_000283	COG4221	oxidoreductase activity
VCD_000284	COG0840	transmembrane signaling receptor activity
VCD_000286	COG2910	NAD(P)H-binding
VCD_000292	COG0673	inositol 2-dehydrogenase activity
VCD_000293	COG3722	fumarate hydratase activity
VCD_000294	COG0246	Mannitol dehydrogenase
VCD_000295	COG2213	PTS system mannitol-specific
VCD_000295	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCD_000297	COG0739	heme binding
VCD_000299	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VCD_000300	COG4597	amino acid ABC transporter
VCD_000301	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VCD_000303	COG1126	abc transporter atp-binding protein
VCD_000304	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VCD_000306	COG0840	transmembrane signaling receptor activity
VCD_000310	COG0840	transmembrane signaling receptor activity
VCD_000313	COG4580	involved in the transport of maltose and maltodextrins
VCD_000316	COG0363	glucosamine-6-phosphate deaminase activity
VCD_000321	COG2259	Doxx family
VCD_000322	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
VCD_000323	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VCD_000325	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
VCD_000326	COG3366	ferrous iron transmembrane transporter activity
VCD_000327	COG0700	Nucleoside recognition
VCD_000329	COG0697	spore germination
VCD_000330	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VCD_000332	COG1764	response to oxidative stress
VCD_000333	COG1846	Transcriptional regulator
VCD_000337	COG2207	Transcriptional regulator
VCD_000338	COG1280	lysine exporter protein (LysE YggA)
VCD_000340	COG1902	pentaerythritol trinitrate reductase activity
VCD_000342	COG1132	(ABC) transporter
VCD_000345	COG1902	pentaerythritol trinitrate reductase activity
VCD_000347	COG0583	DNA-binding transcription factor activity
VCD_000348	COG0513	Belongs to the DEAD box helicase family
VCD_000350	COG0840	transmembrane signaling receptor activity
VCD_000352	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
VCD_000354	COG1304	FMN binding
VCD_000355	COG1620	l-lactate permease
VCD_000356	COG0583	DNA-binding transcription factor activity
VCD_000361	COG4172	Belongs to the ABC transporter superfamily
VCD_000363	COG1067	ATP-dependent peptidase activity
VCD_000364	COG0840	transmembrane signaling receptor activity
VCD_000365	COG2211	Major facilitator Superfamily
VCD_000367	COG3123	guanosine phosphorylase activity
VCD_000368	COG1741	Belongs to the pirin family
VCD_000370	COG5001	Diguanylate cyclase
VCD_000371	COG0583	DNA-binding transcription factor activity
VCD_000378	COG3706	GGDEF domain
VCD_000379	COG1846	Transcriptional regulator
VCD_000380	COG0784	Response regulator, receiver
VCD_000380	COG0835	chemotaxis
VCD_000381	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VCD_000383	COG2197	response regulator
VCD_000384	COG0393	Putative heavy-metal-binding
VCD_000387	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VCD_000388	COG3842	ATPase activity
VCD_000390	COG1175	transmembrane transport
VCD_000391	COG3833	ABC-type maltose transport systems, permease component
VCD_000394	COG1349	DNA-binding transcription factor activity
VCD_000395	COG3706	GGDEF domain
VCD_000397	COG2207	Transcriptional regulator
VCD_000397	COG4753	response regulator
VCD_000400	COG1278	Cold shock
VCD_000401	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VCD_000402	COG2354	Protein conserved in bacteria
VCD_000403	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VCD_000405	COG3152	Membrane
VCD_000407	COG0418	dihydroorotase activity
VCD_000408	COG0633	Ferredoxin
VCD_000408	COG3217	Mosc domain protein beta barrel domain protein
VCD_000408	COG0633	Ferredoxin
VCD_000408	COG3217	Mosc domain protein beta barrel domain protein
VCD_000416	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VCD_000417	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VCD_000418	COG4558	Periplasmic binding protein
VCD_000419	COG0848	biopolymer transport protein
VCD_000420	COG0811	peptide transport
VCD_000421	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VCD_000423	COG3721	Heme iron utilization protein
VCD_000424	COG0748	coenzyme F420 binding
VCD_000426	COG3835	regulator
VCD_000427	COG2610	gluconate transmembrane transporter activity
VCD_000428	COG1929	Belongs to the glycerate kinase type-1 family
VCD_000433	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VCD_000434	COG0363	glucosamine-6-phosphate deaminase activity
VCD_000435	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VCD_000436	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VCD_000437	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
VCD_000441	COG0346	lactoylglutathione lyase activity
VCD_000448	COG1063	alcohol dehydrogenase
VCD_000457	COG0583	DNA-binding transcription factor activity
VCD_000458	COG3048	D-serine ammonia-lyase activity
VCD_000460	COG1294	oxidase, subunit
VCD_000461	COG1271	oxidase subunit
VCD_000462	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VCD_000463	COG1686	Belongs to the peptidase S11 family
VCD_000465	COG3047	cAMP biosynthetic process
VCD_000466	COG3227	Zinc metalloprotease (Elastase)
VCD_000468	COG2267	carboxylic ester hydrolase activity
VCD_000469	COG2067	long-chain fatty acid transport protein
VCD_000470	COG0366	Alpha amylase catalytic
VCD_000471	COG4989	oxidoreductase activity
VCD_000474	COG1136	(ABC) transporter
VCD_000475	COG1136	(ABC) transporter
VCD_000475	COG0577	efflux transmembrane transporter activity
VCD_000478	COG3275	phosphorelay sensor kinase activity
VCD_000479	COG3279	Response regulator of the LytR AlgR family
VCD_000481	COG3706	GGDEF domain
VCD_000482	COG0531	amino acid
VCD_000488	COG1765	OsmC-like protein
VCD_000489	COG1253	flavin adenine dinucleotide binding
VCD_000490	COG2171	N-acyltransferase activity
VCD_000493	COG0583	DNA-binding transcription factor activity
VCD_000494	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VCD_000496	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VCD_000497	COG3186	Phenylalanine-4-hydroxylase
VCD_000498	COG2154	pterin-4-alpha-carbinolamine dehydratase
VCD_000499	COG0456	acetyltransferase
VCD_000500	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VCD_000501	COG0662	Cupin 2, conserved barrel domain protein
VCD_000502	COG0527	aspartate kinase activity
VCD_000504	COG0459	protein refolding
VCD_000505	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VCD_000506	COG2239	Acts as a magnesium transporter
VCD_000509	COG1166	arginine decarboxylase activity
VCD_000510	COG0010	Belongs to the arginase family
VCD_000512	COG3227	Zinc metalloprotease (Elastase)
VCD_000513	COG3397	chitin binding
VCD_000514	COG3046	protein related to deoxyribodipyrimidine photolyase
VCD_000516	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VCD_000518	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
VCD_000519	COG0513	Belongs to the DEAD box helicase family
VCD_000521	COG1368	sulfuric ester hydrolase activity
VCD_000522	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VCD_000525	COG0546	phosphoglycolate phosphatase activity
VCD_000534	COG0484	heat shock protein binding
VCD_000537	COG5001	Diguanylate cyclase
VCD_000537	COG1716	ATPase activity
VCD_000538	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VCD_000540	COG4181	ATPase activity
VCD_000541	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
VCD_000544	COG1984	allophanate hydrolase subunit 2
VCD_000546	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VCD_000547	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VCD_000548	COG0840	transmembrane signaling receptor activity
VCD_000549	COG0814	amino acid
VCD_000551	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
VCD_000552	COG0513	Belongs to the DEAD box helicase family
VCD_000553	COG1309	transcriptional regulator
VCD_000555	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
VCD_000556	COG0494	nUDIX hydrolase
VCD_000558	COG2425	protein containing a von Willebrand factor type A (vWA) domain
VCD_000560	COG1126	abc transporter atp-binding protein
VCD_000561	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VCD_000562	COG4215	(ABC) transporter
VCD_000563	COG4160	amino acid transport
VCD_000564	COG0583	DNA-binding transcription factor activity
VCD_000568	COG3118	belongs to the thioredoxin family
VCD_000569	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VCD_000570	COG0247	lactate metabolic process
VCD_000571	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
VCD_000572	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VCD_000574	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VCD_000575	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VCD_000581	COG2827	Endonuclease containing a URI domain
VCD_000583	COG1879	ABC-type sugar transport system periplasmic component
VCD_000584	COG0784	Response regulator, receiver
VCD_000584	COG5002	protein histidine kinase activity
VCD_000592	COG1492	cobalamin metabolic process
VCD_000593	COG0725	ABC transporter, periplasmic molybdate-binding protein
VCD_000594	COG4149	molybdate abc transporter
VCD_000595	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
VCD_000601	COG1289	transmembrane transporter activity
VCD_000602	COG0210	DNA helicase
VCD_000605	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VCD_000607	COG1335	isochorismatase
VCD_000608	COG1803	Methylglyoxal synthase
VCD_000609	COG1879	ABC-type sugar transport system periplasmic component
VCD_000610	COG0784	Response regulator, receiver
VCD_000610	COG2205	protein histidine kinase activity
VCD_000610	COG2198	Histidine kinase
VCD_000611	COG0469	pyruvate kinase activity
VCD_000612	COG2271	Major facilitator Superfamily
VCD_000613	COG1840	ABC-type Fe3 transport system, periplasmic component
VCD_000614	COG4191	Histidine kinase
VCD_000617	COG1979	alcohol dehydrogenase
VCD_000619	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VCD_000620	COG3706	GGDEF domain
VCD_000629	COG2131	deaminase
VCD_000632	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VCD_000633	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VCD_000635	COG0183	Belongs to the thiolase family
VCD_000637	COG3243	poly(R)-hydroxyalkanoic acid synthase
VCD_000638	COG3842	ATPase activity
VCD_000640	COG1840	ABC-type Fe3 transport system, periplasmic component
VCD_000641	COG2271	Major facilitator Superfamily
VCD_000642	COG3851	Histidine kinase
VCD_000643	COG2197	response regulator
VCD_000644	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VCD_000648	COG0243	molybdopterin cofactor binding
VCD_000650	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VCD_000651	COG3850	Histidine kinase
VCD_000652	COG2197	response regulator
VCD_000653	COG1609	Transcriptional regulator
VCD_000658	COG1760	l-serine dehydratase
VCD_000659	COG3069	C4-dicarboxylate transmembrane transporter activity
VCD_000660	COG0840	transmembrane signaling receptor activity
VCD_000661	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VCD_000662	COG0545	Peptidyl-prolyl cis-trans isomerase
VCD_000663	COG2885	chlorophyll binding
VCD_000665	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VCD_000666	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VCD_000667	COG1621	beta-fructofuranosidase activity
VCD_000669	COG1263	PTS System
VCD_000669	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VCD_000678	COG0446	pyridine nucleotide-disulphide oxidoreductase
VCD_000680	COG0640	Transcriptional regulator
VCD_000685	COG0778	Nitroreductase
VCD_000686	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
VCD_000687	COG0583	DNA-binding transcription factor activity
VCD_000692	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VCD_000697	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VCD_000698	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VCD_000700	COG2390	Transcriptional regulator
VCD_000701	COG2897	thiosulfate sulfurtransferase activity
VCD_000703	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VCD_000705	COG0302	gtp cyclohydrolase
VCD_000706	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VCD_000706	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VCD_000707	COG2759	Belongs to the formate--tetrahydrofolate ligase family
VCD_000708	COG1970	mechanosensitive ion channel activity
VCD_000709	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
VCD_000711	COG1011	Hydrolase
VCD_000712	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VCD_000713	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VCD_000715	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VCD_000717	COG3842	ATPase activity
VCD_000726	COG4166	transmembrane transport
VCD_000727	COG4174	ABC transporter (Permease)
VCD_000728	COG4239	(ABC) transporter, permease
VCD_000729	COG4172	Belongs to the ABC transporter superfamily
VCD_000730	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VCD_000733	COG0625	glutathione transferase activity
VCD_000738	COG2050	protein possibly involved in aromatic compounds catabolism
VCD_000742	COG4771	TonB-dependent receptor
VCD_000742	COG1629	transport
VCD_000743	COG0583	DNA-binding transcription factor activity
VCD_000744	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VCD_000744	COG1042	CoA-binding domain protein
VCD_000744	COG0045	succinate-CoA ligase (ADP-forming) activity
VCD_000746	COG1181	Belongs to the D-alanine--D-alanine ligase family
VCD_000748	COG0023	Translation Initiation Factor
VCD_000751	COG4128	Pfam Zonular occludens toxin
VCD_000762	COG0745	RESPONSE REGULATOR receiver
VCD_000764	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VCD_000765	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VCD_000768	COG3706	GGDEF domain
VCD_000778	COG2824	Alkylphosphonate utilization operon protein PhnA
VCD_000782	COG0737	Belongs to the 5'-nucleotidase family
VCD_000783	COG3593	DNA synthesis involved in DNA repair
VCD_000785	COG0583	DNA-binding transcription factor activity
VCD_000787	COG2116	formate transmembrane transporter activity
VCD_000789	COG3038	cytochrome b561
VCD_000791	COG2200	EAL domain
VCD_000794	COG0586	Pfam SNARE associated Golgi protein
VCD_000795	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VCD_000796	COG0745	RESPONSE REGULATOR receiver
VCD_000797	COG2205	protein histidine kinase activity
VCD_000798	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VCD_000798	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
VCD_000798	COG1013	pyruvate-flavodoxin oxidoreductase activity
VCD_000798	COG0674	pyruvate-flavodoxin oxidoreductase activity
VCD_000799	COG3158	transport of potassium into the cell
VCD_000801	COG0523	cobalamin synthesis protein
VCD_000802	COG0038	chloride channel
VCD_000804	COG0156	8-amino-7-oxononanoate synthase activity
VCD_000805	COG2205	protein histidine kinase activity
VCD_000805	COG0784	Response regulator, receiver
VCD_000806	COG0419	ATPase involved in DNA repair
VCD_000807	COG0420	3'-5' exonuclease activity
VCD_000808	COG1609	Transcriptional regulator
VCD_000809	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCD_000809	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCD_000810	COG1105	Belongs to the carbohydrate kinase PfkB family
VCD_000811	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
VCD_000811	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCD_000811	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCD_000813	COG0189	ligase activity
VCD_000813	COG4067	protein conserved in archaea
VCD_000815	COG0602	queuosine metabolic process
VCD_000816	COG1328	CTP reductase activity
VCD_000820	COG0346	lactoylglutathione lyase activity
VCD_000832	COG1943	Transposase
VCD_000863	COG0346	lactoylglutathione lyase activity
VCD_000866	COG0110	maltose O-acetyltransferase activity
VCD_000867	COG3039	Transposase
VCD_000869	COG2944	sequence-specific DNA binding
VCD_000870	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
VCD_000881	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
VCD_000889	COG3040	lipid binding
VCD_000892	COG1619	proteins homologs of microcin C7 resistance protein MccF
VCD_000895	COG3093	addiction module antidote protein HigA
VCD_000896	COG3549	Plasmid maintenance system killer
VCD_000930	COG1280	lysine exporter protein (LysE YggA)
VCD_000931	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
VCD_000933	COG3040	lipid binding
VCD_000936	COG0346	lactoylglutathione lyase activity
VCD_000944	COG1619	proteins homologs of microcin C7 resistance protein MccF
VCD_000963	COG3040	lipid binding
VCD_000964	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VCD_000966	COG0494	nUDIX hydrolase
VCD_000970	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VCD_000979	COG1028	Short-chain dehydrogenase reductase Sdr
VCD_000985	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
VCD_000986	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VCD_000988	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VCD_000992	COG3039	Transposase
VCD_000994	COG0404	The glycine cleavage system catalyzes the degradation of glycine
VCD_000996	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VCD_000997	COG0509	glycine decarboxylation via glycine cleavage system
VCD_000998	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VCD_000998	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VCD_000999	COG1943	Transposase
VCD_001003	COG1686	Belongs to the peptidase S11 family
VCD_001006	COG2814	Major facilitator Superfamily
VCD_001009	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VCD_001015	COG5002	protein histidine kinase activity
VCD_001016	COG0745	RESPONSE REGULATOR receiver
VCD_001018	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VCD_001019	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VCD_001020	COG0842	Transport permease protein
VCD_001021	COG1131	(ABC) transporter
VCD_001022	COG0659	secondary active sulfate transmembrane transporter activity
VCD_001023	COG0288	reversible hydration of carbon dioxide
VCD_001026	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VCD_001027	COG3107	peptidoglycan biosynthetic process
VCD_001028	COG0792	nuclease activity
VCD_001029	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VCD_001030	COG2823	Periplasmic or secreted lipoprotein
VCD_001031	COG2969	positive regulation of protein catabolic process
VCD_001032	COG0625	glutathione transferase activity
VCD_001033	COG2857	Cytochrome c1
VCD_001034	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VCD_001035	COG0723	plastoquinol--plastocyanin reductase activity
VCD_001036	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VCD_001037	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VCD_001038	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VCD_001040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VCD_001041	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VCD_001042	COG0335	large ribosomal subunit rRNA binding
VCD_001043	COG0336	Belongs to the RNA methyltransferase TrmD family
VCD_001044	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VCD_001045	COG0228	four-way junction DNA binding
VCD_001046	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VCD_001047	COG4137	Cytochrome C assembly protein
VCD_001048	COG4536	flavin adenine dinucleotide binding
VCD_001049	COG1854	S-ribosylhomocysteine lyase activity
VCD_001050	COG2918	glutathione biosynthetic process
VCD_001051	COG0612	Peptidase, M16
VCD_001052	COG1238	metal cluster binding
VCD_001054	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VCD_001055	COG0511	ligase activity, forming carbon-carbon bonds
VCD_001055	COG5016	pyruvate
VCD_001056	COG3630	sodium ion export across plasma membrane
VCD_001057	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
VCD_001058	COG0527	aspartate kinase activity
VCD_001060	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VCD_001061	COG2137	regulation of response to DNA damage stimulus
VCD_001062	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VCD_001064	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
VCD_001065	COG4208	sulfate ABC transporter
VCD_001070	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VCD_001071	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VCD_001072	COG4942	peptidase
VCD_001072	COG1388	LysM domain
VCD_001073	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VCD_001074	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VCD_001075	COG0585	pseudouridine synthase activity
VCD_001076	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VCD_001077	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VCD_001078	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VCD_001079	COG1968	undecaprenyl-diphosphatase activity
VCD_001080	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VCD_001081	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VCD_001082	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VCD_001084	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VCD_001085	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VCD_001086	COG1610	YqeY-like protein
VCD_001087	COG0358	DNA primase activity
VCD_001088	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VCD_001089	COG0582	viral genome integration into host DNA
VCD_001090	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VCD_001092	COG2207	Transcriptional regulator
VCD_001093	COG0840	transmembrane signaling receptor activity
VCD_001095	COG2003	Belongs to the UPF0758 family
VCD_001102	COG0739	heme binding
VCD_001109	COG0328	RNA-DNA hybrid ribonuclease activity
VCD_001118	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VCD_001119	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VCD_001120	COG1349	DNA-binding transcription factor activity
VCD_001121	COG0469	pyruvate kinase activity
VCD_001123	COG0583	DNA-binding transcription factor activity
VCD_001124	COG1279	arginine transmembrane transporter activity
VCD_001125	COG0668	transmembrane transport
VCD_001127	COG0191	fructose-bisphosphate aldolase activity
VCD_001128	COG0126	phosphoglycerate kinase activity
VCD_001129	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VCD_001130	COG4771	TonB-dependent receptor
VCD_001131	COG0583	DNA-binding transcription factor activity
VCD_001133	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VCD_001134	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VCD_001135	COG3091	SprT-like family
VCD_001136	COG2356	endonuclease I
VCD_001137	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VCD_001138	COG0189	ligase activity
VCD_001139	COG1678	Uncharacterized ACR, COG1678
VCD_001140	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VCD_001141	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VCD_001146	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VCD_001147	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VCD_001148	COG0762	integral membrane protein
VCD_001149	COG1872	DUF167
VCD_001151	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VCD_001152	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VCD_001153	COG2066	Belongs to the glutaminase family
VCD_001154	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VCD_001155	COG1194	a g-specific adenine glycosylase
VCD_001156	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VCD_001157	COG0741	lytic transglycosylase activity
VCD_001159	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VCD_001160	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VCD_001161	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VCD_001162	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VCD_001163	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VCD_001164	COG2967	ApaG domain
VCD_001165	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VCD_001167	COG3610	response to peptide
VCD_001168	COG2966	Psort location CytoplasmicMembrane, score
VCD_001169	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VCD_001170	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VCD_001171	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VCD_001172	COG0142	geranyltranstransferase activity
VCD_001175	COG0039	L-malate dehydrogenase activity
VCD_001176	COG1438	arginine binding
VCD_001179	COG0589	response to stress
VCD_001185	COG3550	peptidyl-serine autophosphorylation
VCD_001188	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VCD_001190	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VCD_001199	COG2235	arginine
VCD_001200	COG0312	modulator of DNA gyrase
VCD_001201	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VCD_001202	COG3164	Protein of unknown function
VCD_001203	COG1530	ribonuclease E activity
VCD_001204	COG0424	maF-like protein
VCD_001205	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VCD_001206	COG1792	Involved in formation and maintenance of cell shape
VCD_001207	COG1077	Cell shape determining protein MreB Mrl
VCD_001217	COG1459	type II secretion system
VCD_001218	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VCD_001220	COG3267	Type II secretory pathway component ExeA
VCD_001220	COG3409	Peptidoglycan-binding domain 1 protein
VCD_001225	COG2200	EAL domain
VCD_001225	COG2199	diguanylate cyclase activity
VCD_001226	COG0629	single-stranded DNA binding
VCD_001229	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VCD_001231	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VCD_001232	COG0527	aspartate kinase activity
VCD_001233	COG0646	methionine synthase
VCD_001233	COG1410	methionine synthase
VCD_001237	COG0175	sulfate reduction
VCD_001238	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VCD_001239	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VCD_001244	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VCD_001246	COG0735	belongs to the Fur family
VCD_001250	COG0166	Belongs to the GPI family
VCD_001251	COG0432	Pfam Uncharacterised protein family UPF0047
VCD_001252	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VCD_001253	COG0305	Participates in initiation and elongation during chromosome replication
VCD_001255	COG0359	binds to the 23S rRNA
VCD_001256	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
VCD_001257	COG2965	DNA replication, synthesis of RNA primer
VCD_001258	COG0360	Binds together with S18 to 16S ribosomal RNA
VCD_001260	COG2906	2 iron, 2 sulfur cluster binding
VCD_001261	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VCD_001262	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VCD_001263	COG0049	tRNA binding
VCD_001264	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
VCD_001266	COG2923	Belongs to the DsrF TusC family
VCD_001267	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VCD_001268	COG2964	Protein conserved in bacteria
VCD_001269	COG0545	Peptidyl-prolyl cis-trans isomerase
VCD_001271	COG2900	Belongs to the SlyX family
VCD_001272	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VCD_001273	COG0330	HflC and HflK could
VCD_001274	COG0330	HflC and HflK could
VCD_001275	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VCD_001276	COG1923	regulation of RNA biosynthetic process
VCD_001277	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VCD_001278	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VCD_001280	COG0802	atpase or kinase
VCD_001281	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VCD_001282	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VCD_001283	COG1162	GTPase activity
VCD_001284	COG1162	GTPase activity
VCD_001285	COG0688	phosphatidylethanolamine metabolic process
VCD_001286	COG0490	domain, Protein
VCD_001286	COG0471	metal ion transport
VCD_001288	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VCD_001289	COG4942	peptidase
VCD_001292	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VCD_001293	COG2816	NAD+ diphosphatase activity
VCD_001294	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VCD_001295	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VCD_001296	COG0085	RNA polymerase activity
VCD_001297	COG0222	ribosome binding
VCD_001298	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VCD_001299	COG0081	regulation of translation
VCD_001300	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VCD_001301	COG0250	Participates in transcription elongation, termination and antitermination
VCD_001302	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VCD_001303	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VCD_001304	COG1072	(Pantothenic acid kinase))
VCD_001306	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VCD_001308	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VCD_001312	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VCD_001314	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
VCD_001315	COG3118	belongs to the thioredoxin family
VCD_001316	COG0513	Belongs to the DEAD box helicase family
VCD_001317	COG0248	Ppx GppA phosphatase
VCD_001318	COG2205	protein histidine kinase activity
VCD_001318	COG0784	Response regulator, receiver
VCD_001319	COG2814	Major facilitator Superfamily
VCD_001322	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VCD_001323	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VCD_001324	COG0511	ligase activity, forming carbon-carbon bonds
VCD_001325	COG0439	Biotin carboxylase
VCD_001327	COG2264	protein methyltransferase activity
VCD_001329	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VCD_001330	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VCD_001331	COG1609	Transcriptional regulator
VCD_001332	COG0129	dihydroxy-acid dehydratase activity
VCD_001333	COG3265	gluconokinase activity
VCD_001335	COG0800	Aldolase
VCD_001339	COG0840	transmembrane signaling receptor activity
VCD_001340	COG1982	Orn Lys Arg decarboxylase major
VCD_001341	COG0531	amino acid
VCD_001342	COG3710	Transcriptional regulator
VCD_001343	COG0789	Transcriptional regulator
VCD_001345	COG0138	bifunctional purine biosynthesis protein purh
VCD_001346	COG0151	Belongs to the GarS family
VCD_001348	COG0776	regulation of translation
VCD_001350	COG1253	flavin adenine dinucleotide binding
VCD_001351	COG1940	carbohydrate kinase activity
VCD_001353	COG3068	Protein conserved in bacteria
VCD_001355	COG1573	uracil-dna glycosylase
VCD_001356	COG0668	transmembrane transport
VCD_001357	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VCD_001359	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VCD_001367	COG1012	belongs to the aldehyde dehydrogenase family
VCD_001367	COG1454	alcohol dehydrogenase
VCD_001368	COG0318	PFAM AMP-dependent synthetase and ligase
VCD_001374	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
VCD_001375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VCD_001376	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
VCD_001376	COG0662	Cupin 2, conserved barrel domain protein
VCD_001377	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VCD_001384	COG1519	Transferase
VCD_001390	COG3642	lipopolysaccharide core region biosynthetic process
VCD_001391	COG0859	PFAM glycosyl transferase family 9
VCD_001392	COG0463	Glycosyl transferase, family 2
VCD_001393	COG0859	PFAM glycosyl transferase family 9
VCD_001394	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VCD_001395	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VCD_001397	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VCD_001398	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VCD_001401	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VCD_001402	COG1309	transcriptional regulator
VCD_001403	COG1560	Kdo2-lipid A biosynthetic process
VCD_001404	COG1560	Kdo2-lipid A biosynthetic process
VCD_001405	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VCD_001406	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VCD_001407	COG1561	YicC-like family, N-terminal region
VCD_001409	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VCD_001409	COG1263	PTS System
VCD_001410	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VCD_001414	COG1120	ATPase activity
VCD_001415	COG4774	siderophore transport
VCD_001416	COG1132	(ABC) transporter
VCD_001419	COG0514	ATP-dependent DNA helicase (RecQ)
VCD_001420	COG2962	Rard protein
VCD_001423	COG1280	lysine exporter protein (LysE YggA)
VCD_001424	COG0210	DNA helicase
VCD_001426	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VCD_001427	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VCD_001435	COG2131	deaminase
VCD_001437	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VCD_001439	COG0747	negative chemotaxis
VCD_001443	COG1309	transcriptional regulator
VCD_001444	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCD_001445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VCD_001446	COG2960	long-chain fatty acid transporting porin activity
VCD_001447	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VCD_001448	COG0583	DNA-binding transcription factor activity
VCD_001451	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
VCD_001452	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VCD_001453	COG1739	Uncharacterized protein family UPF0029
VCD_001454	COG1250	3-hydroxyacyl-CoA dehydrogenase
VCD_001454	COG1024	Enoyl-CoA hydratase
VCD_001455	COG0183	Belongs to the thiolase family
VCD_001456	COG0583	DNA-binding transcription factor activity
VCD_001457	COG2814	Major facilitator Superfamily
VCD_001458	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VCD_001459	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VCD_001460	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VCD_001461	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VCD_001462	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VCD_001463	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VCD_001464	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VCD_001466	COG0356	it plays a direct role in the translocation of protons across the membrane
VCD_001467	COG3312	ion transport
VCD_001468	COG1475	DNA binding
VCD_001469	COG1192	Involved in chromosome partitioning
VCD_001470	COG0357	Ribosomal RNA small subunit methyltransferase G
VCD_001471	COG0445	tRNA wobble uridine modification
VCD_001472	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VCD_001473	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VCD_001474	COG0706	membrane insertase activity
VCD_001475	COG0594	ribonuclease P activity
VCD_001476	COG0230	Belongs to the bacterial ribosomal protein bL34 family
VCD_001477	COG1126	abc transporter atp-binding protein
VCD_001480	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VCD_001481	COG0592	DNA-directed DNA polymerase activity
VCD_001482	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VCD_001483	COG0187	DNA topoisomerase II activity
VCD_001486	COG0071	Belongs to the small heat shock protein (HSP20) family
VCD_001487	COG3977	Valine--pyruvate aminotransferase
VCD_001488	COG0751	glycine-tRNA ligase activity
VCD_001489	COG0752	glycyl-tRNA synthetase alpha subunit
VCD_001490	COG2119	membrane
VCD_001492	COG0425	Belongs to the sulfur carrier protein TusA family
VCD_001494	COG0604	alcohol dehydrogenase
VCD_001496	COG0129	dihydroxy-acid dehydratase activity
VCD_001497	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VCD_001500	COG0606	chelatase, subunit chli
VCD_001501	COG0204	Acyl-transferase
VCD_001502	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VCD_001503	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VCD_001505	COG3084	Protein conserved in bacteria
VCD_001508	COG4326	sporulation control protein
VCD_001509	COG1272	protein, Hemolysin III
VCD_001511	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VCD_001512	COG0569	domain protein
VCD_001513	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VCD_001513	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VCD_001514	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VCD_001515	COG0242	peptide deformylase activity
VCD_001516	COG1652	LysM domain
VCD_001517	COG0758	DNA mediated transformation
VCD_001518	COG2922	Belongs to the Smg family
VCD_001519	COG0551	DNA topoisomerase type I activity
VCD_001520	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VCD_001521	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VCD_001522	COG0009	L-threonylcarbamoyladenylate synthase
VCD_001523	COG0408	coproporphyrinogen oxidase activity
VCD_001524	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VCD_001526	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VCD_001528	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VCD_001529	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VCD_001531	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VCD_001532	COG2104	thiamine diphosphate biosynthetic process
VCD_001533	COG2022	thiamine diphosphate biosynthetic process
VCD_001534	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VCD_001535	COG0006	proline dipeptidase activity
VCD_001535	COG0006	proline dipeptidase activity
VCD_001539	COG1522	sequence-specific DNA binding
VCD_001540	COG5001	Diguanylate cyclase
VCD_001540	COG5002	protein histidine kinase activity
VCD_001541	COG0742	ribosomal rna small subunit methyltransferase
VCD_001543	COG0697	spore germination
VCD_001544	COG0589	response to stress
VCD_001545	COG1528	Iron-storage protein
VCD_001547	COG2081	HI0933 family
VCD_001549	COG1322	Protein conserved in bacteria
VCD_001550	COG2226	methyltransferase
VCD_001552	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VCD_001553	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VCD_001554	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VCD_001555	COG0805	protein transport
VCD_001556	COG1858	cytochrome C peroxidase
VCD_001557	COG0534	Mate efflux family protein
VCD_001559	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VCD_001560	COG2937	Belongs to the GPAT DAPAT family
VCD_001561	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VCD_001562	COG3161	chorismate lyase activity
VCD_001563	COG1580	Controls the rotational direction of flagella during chemotaxis
VCD_001564	COG0840	transmembrane signaling receptor activity
VCD_001566	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VCD_001567	COG0084	hydrolase, TatD family'
VCD_001570	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VCD_001570	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VCD_001571	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VCD_001574	COG3078	GTPase activator activity
VCD_001576	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VCD_001577	COG3071	HemY protein
VCD_001578	COG2959	enzyme of heme biosynthesis
VCD_001579	COG1587	Uroporphyrinogen-III synthase
VCD_001580	COG0181	hydroxymethylbilane synthase activity
VCD_001582	COG3072	Adenylate cyclase
VCD_001583	COG1965	Belongs to the frataxin family
VCD_001585	COG0019	diaminopimelate decarboxylase activity
VCD_001586	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VCD_001588	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VCD_001589	COG1011	Hydrolase
VCD_001590	COG3287	FIST C domain
VCD_001590	COG2199	diguanylate cyclase activity
VCD_001590	COG2200	EAL domain
VCD_001593	COG0561	phosphatase activity
VCD_001594	COG2267	carboxylic ester hydrolase activity
VCD_001595	COG1280	lysine exporter protein (LysE YggA)
VCD_001596	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VCD_001597	COG0783	Belongs to the Dps family
VCD_001603	COG0742	ribosomal rna small subunit methyltransferase
VCD_001604	COG0552	protein localization to endoplasmic reticulum
VCD_001605	COG2884	Cell division ATP-binding protein ftsE
VCD_001606	COG2177	Part of the ABC transporter FtsEX involved in
VCD_001607	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VCD_001608	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VCD_001611	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VCD_001612	COG4206	TonB-dependent receptor
VCD_001613	COG1404	Belongs to the peptidase S8 family
VCD_001614	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VCD_001617	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VCD_001618	COG3300	MHYT domain
VCD_001618	COG5001	Diguanylate cyclase
VCD_001620	COG3852	Histidine kinase
VCD_001622	COG0174	glutamine synthetase
VCD_001625	COG1660	Displays ATPase and GTPase activities
VCD_001627	COG1490	D-aminoacyl-tRNA deacylase activity
VCD_001628	COG0456	acetyltransferase
VCD_001630	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VCD_001631	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VCD_001632	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VCD_001633	COG3031	protein transport across the cell outer membrane
VCD_001635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VCD_001636	COG1459	type II secretion system
VCD_001637	COG2165	general secretion pathway protein
VCD_001638	COG2165	general secretion pathway protein
VCD_001639	COG2165	general secretion pathway protein
VCD_001640	COG4795	General secretion pathway protein
VCD_001641	COG3156	type II secretion system protein K
VCD_001642	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VCD_001643	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VCD_001645	COG1218	3'(2'),5'-bisphosphate nucleotidase
VCD_001646	COG0494	nUDIX hydrolase
VCD_001647	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VCD_001647	COG0316	Belongs to the HesB IscA family
VCD_001648	COG1040	competence protein
VCD_001649	COG0596	Alpha beta hydrolase
VCD_001651	COG2183	response to ionizing radiation
VCD_001652	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VCD_001653	COG0745	RESPONSE REGULATOR receiver
VCD_001655	COG2233	PERMEase
VCD_001656	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VCD_001657	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VCD_001658	COG1758	RNA polymerase activity
VCD_001659	COG0194	GDP metabolic process
VCD_001660	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VCD_001661	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VCD_001663	COG3263	regulation of cellular component size
VCD_001665	COG4232	protein-disulfide reductase activity
VCD_001669	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VCD_001670	COG1027	Aspartate ammonia-lyase
VCD_001671	COG3706	GGDEF domain
VCD_001672	COG3030	protein affecting phage T7 exclusion by the F plasmid
VCD_001673	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VCD_001675	COG2205	protein histidine kinase activity
VCD_001676	COG0745	RESPONSE REGULATOR receiver
VCD_001678	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VCD_001679	COG0205	6-phosphofructokinase activity
VCD_001680	COG1494	fructose-1,6-bisphosphatase
VCD_001681	COG3074	FtsZ-dependent cytokinesis
VCD_001682	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VCD_001684	COG0460	homoserine dehydrogenase
VCD_001684	COG0527	aspartate kinase activity
VCD_001685	COG0626	cystathionine gamma-synthase activity
VCD_001686	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
VCD_001687	COG0281	malic enzyme
VCD_001688	COG0254	rRNA binding
VCD_001689	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VCD_001690	COG1609	Transcriptional regulator
VCD_001691	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VCD_001692	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VCD_001693	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VCD_001694	COG1575	Belongs to the MenA family. Type 1 subfamily
VCD_001695	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VCD_001697	COG0149	triose-phosphate isomerase activity
VCD_001702	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VCD_001703	COG0459	protein refolding
VCD_001705	COG1509	lysine 2,3-aminomutase activity
VCD_001706	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VCD_001707	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VCD_001708	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VCD_001709	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VCD_001710	COG1053	succinate dehydrogenase
VCD_001711	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VCD_001712	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VCD_001713	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VCD_001714	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VCD_001715	COG1045	serine acetyltransferase
VCD_001717	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VCD_001718	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VCD_001719	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VCD_001720	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VCD_001721	COG0137	argininosuccinate synthase activity
VCD_001723	COG0165	Argininosuccinate lyase
VCD_001725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VCD_001726	COG0678	peroxiredoxin activity
VCD_001726	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VCD_001728	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VCD_001734	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VCD_001735	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VCD_001737	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VCD_001738	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VCD_001739	COG0546	phosphoglycolate phosphatase activity
VCD_001740	COG0180	Tryptophanyl-tRNA synthetase
VCD_001743	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VCD_001745	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VCD_001747	COG1012	belongs to the aldehyde dehydrogenase family
VCD_001749	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VCD_001750	COG3954	Phosphoribulokinase
VCD_001753	COG0429	hydrolase of the alpha beta-hydrolase fold
VCD_001755	COG0488	(ABC) transporter
VCD_001756	COG2249	NAD(P)H dehydrogenase (quinone) activity
VCD_001759	COG1047	Peptidyl-prolyl cis-trans
VCD_001761	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VCD_001762	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VCD_001763	COG3083	sulfuric ester hydrolase activity
VCD_001764	COG0557	exoribonuclease II activity
VCD_001765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VCD_001766	COG0051	transcription antitermination factor activity, RNA binding
VCD_001767	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VCD_001768	COG0088	Forms part of the polypeptide exit tunnel
VCD_001769	COG0089	rRNA binding
VCD_001770	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VCD_001771	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VCD_001772	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VCD_001773	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VCD_001774	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VCD_001775	COG0255	Belongs to the universal ribosomal protein uL29 family
VCD_001776	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VCD_001777	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VCD_001778	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VCD_001779	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VCD_001780	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VCD_001781	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VCD_001782	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VCD_001783	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VCD_001784	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VCD_001785	COG1841	ribosomal large subunit assembly
VCD_001786	COG0200	Binds to the 23S rRNA
VCD_001787	COG0201	protein transport
VCD_001789	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VCD_001790	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VCD_001791	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VCD_001792	COG0202	RNA polymerase activity
VCD_001793	COG0203	ribosomal protein L17
VCD_001795	COG0545	Peptidyl-prolyl cis-trans isomerase
VCD_001796	COG3266	domain, Protein
VCD_001796	COG3061	Opacity-associated protein A
VCD_001797	COG0697	spore germination
VCD_001798	COG2153	protein acetylation
VCD_001799	COG0513	Belongs to the DEAD box helicase family
VCD_001801	COG0737	Belongs to the 5'-nucleotidase family
VCD_001802	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VCD_001802	COG1648	precorrin-2 dehydrogenase activity
VCD_001803	COG0175	sulfate reduction
VCD_001804	COG2895	sulfate adenylyltransferase (ATP) activity
VCD_001805	COG0529	Catalyzes the synthesis of activated sulfate
VCD_001809	COG1136	(ABC) transporter
VCD_001812	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VCD_001813	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VCD_001814	COG0729	surface antigen
VCD_001816	COG2105	PFAM AIG2 family protein
VCD_001817	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VCD_001818	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VCD_001819	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VCD_001820	COG0163	prenyltransferase activity
VCD_001821	COG4143	(ABC) transporter
VCD_001822	COG1178	ABC-type Fe3 transport system permease component
VCD_001823	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VCD_001824	COG3028	Belongs to the UPF0307 family
VCD_001825	COG0312	modulator of DNA gyrase
VCD_001826	COG2239	Acts as a magnesium transporter
VCD_001827	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCD_001828	COG1660	Displays ATPase and GTPase activities
VCD_001829	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCD_001830	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VCD_001832	COG1137	ATPase activity
VCD_001833	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VCD_001836	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VCD_001836	COG0517	IMP dehydrogenase activity
VCD_001838	COG1127	ABC transporter
VCD_001839	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VCD_001840	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VCD_001841	COG2854	intermembrane phospholipid transfer
VCD_001843	COG5007	Belongs to the BolA IbaG family
VCD_001844	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VCD_001845	COG0204	Acyl-transferase
VCD_001846	COG0251	oxidation-reduction process
VCD_001847	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VCD_001848	COG0540	Belongs to the ATCase OTCase family
VCD_001849	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VCD_001850	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VCD_001851	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VCD_001852	COG0564	pseudouridine synthase activity
VCD_001853	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VCD_001854	COG0525	valine-tRNA ligase activity
VCD_001855	COG2927	DNA polymerase III (CHI subunit)
VCD_001856	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VCD_001857	COG0795	lipopolysaccharide-transporting ATPase activity
VCD_001858	COG0795	lipopolysaccharide-transporting ATPase activity
VCD_001860	COG3437	response regulator, receiver
VCD_001863	COG0066	3-isopropylmalate dehydratase activity
VCD_001864	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VCD_001865	COG0473	3-isopropylmalate dehydrogenase activity
VCD_001866	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VCD_001871	COG0583	DNA-binding transcription factor activity
VCD_001872	COG1022	Amp-dependent synthetase and ligase
VCD_001873	COG0028	Belongs to the TPP enzyme family
VCD_001874	COG0440	acetolactate synthase activity
VCD_001875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VCD_001876	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VCD_001877	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VCD_001878	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VCD_001880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VCD_001881	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VCD_001883	COG0354	folic acid binding
VCD_001884	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VCD_001886	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VCD_001887	COG1595	DNA-templated transcription, initiation
VCD_001889	COG3026	antisigma factor binding
VCD_001890	COG3086	response to oxidative stress
VCD_001891	COG0481	GTPase activity
VCD_001892	COG0681	Belongs to the peptidase S26 family
VCD_001893	COG0571	ribonuclease III activity
VCD_001894	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VCD_001895	COG1381	Involved in DNA repair and RecF pathway recombination
VCD_001896	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VCD_001897	COG0736	holo-[acyl-carrier-protein] synthase activity
VCD_001900	COG5001	Diguanylate cyclase
VCD_001902	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VCD_001903	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VCD_001904	COG3956	TIGRFAM MazG family protein
VCD_001906	COG0504	CTP synthase activity
VCD_001907	COG0148	phosphopyruvate hydratase activity
VCD_001908	COG0617	tRNA 3'-terminal CCA addition
VCD_001909	COG3267	Type II secretory pathway component ExeA
VCD_001909	COG3409	Peptidoglycan-binding domain 1 protein
VCD_001911	COG4991	sh3 domain protein
VCD_001912	COG0306	phosphate transporter
VCD_001914	COG1392	Phosphate transport regulator
VCD_001915	COG3025	triphosphatase activity
VCD_001916	COG0840	transmembrane signaling receptor activity
VCD_001917	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VCD_001919	COG1538	Outer membrane efflux protein
VCD_001920	COG0494	nUDIX hydrolase
VCD_001921	COG3151	Protein conserved in bacteria
VCD_001923	COG3150	esterase
VCD_001924	COG0187	DNA topoisomerase II activity
VCD_001925	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VCD_001926	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VCD_001927	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VCD_001928	COG0237	dephospho-CoA kinase activity
VCD_001930	COG1459	type II secretion system
VCD_001931	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VCD_001935	COG0716	FMN binding
VCD_001936	COG4974	Belongs to the 'phage' integrase family
VCD_001937	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VCD_001938	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VCD_001939	COG0737	Belongs to the 5'-nucleotidase family
VCD_001940	COG2186	Transcriptional regulator
VCD_001941	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VCD_001942	COG0508	dehydrogenase complex catalyzes the overall conversion of
VCD_001943	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VCD_001944	COG0275	rRNA processing
VCD_001945	COG3116	cell division
VCD_001946	COG0768	penicillin binding
VCD_001947	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VCD_001948	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VCD_001949	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VCD_001950	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VCD_001951	COG0772	Belongs to the SEDS family
VCD_001952	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VCD_001953	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VCD_001954	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VCD_001955	COG0849	cell division
VCD_001956	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VCD_001957	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VCD_001959	COG0653	protein targeting
VCD_001960	COG0494	nUDIX hydrolase
VCD_001961	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VCD_001962	COG0505	Belongs to the CarA family
VCD_001963	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VCD_001965	COG4172	Belongs to the ABC transporter superfamily
VCD_001967	COG0730	response to heat
VCD_001968	COG0583	DNA-binding transcription factor activity
VCD_001969	COG2860	membrane
VCD_001970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VCD_001972	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VCD_001974	COG0493	'glutamate synthase
VCD_001975	COG0067	glutamate synthase
VCD_001975	COG0069	glutamate synthase activity
VCD_001975	COG0070	glutamate synthase
VCD_001977	COG0069	glutamate synthase activity
VCD_001977	COG0067	glutamate synthase
VCD_001977	COG0070	glutamate synthase
VCD_001978	COG1242	4 iron, 4 sulfur cluster binding
VCD_001979	COG3706	GGDEF domain
VCD_001979	COG2203	Gaf domain
VCD_001979	COG4251	negative regulation of phosphorylation
VCD_001979	COG5001	Diguanylate cyclase
VCD_001980	COG2198	Histidine kinase
VCD_001980	COG5002	protein histidine kinase activity
VCD_001980	COG0784	Response regulator, receiver
VCD_001981	COG0745	RESPONSE REGULATOR receiver
VCD_001983	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VCD_001986	COG0083	homoserine kinase activity
VCD_001987	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VCD_001988	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VCD_001989	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VCD_001990	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VCD_001993	COG1115	amino acid carrier protein
VCD_001996	COG0084	hydrolase, TatD family'
VCD_001997	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VCD_001998	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VCD_001999	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VCD_002000	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VCD_002001	COG0813	purine-nucleoside phosphorylase activity
VCD_002003	COG0560	Phosphoserine phosphatase
VCD_002005	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VCD_002006	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VCD_002007	COG1022	Amp-dependent synthetase and ligase
VCD_002010	COG3250	beta-galactosidase activity
VCD_002011	COG1609	Transcriptional regulator
VCD_002012	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VCD_002016	COG0189	ligase activity
VCD_002016	COG0569	domain protein
VCD_002017	COG0456	acetyltransferase
VCD_002019	COG2171	N-acyltransferase activity
VCD_002020	COG3141	response to X-ray
VCD_002023	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VCD_002024	COG1074	ATP-dependent DNA helicase activity
VCD_002025	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VCD_002027	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VCD_002027	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VCD_002031	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VCD_002032	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VCD_002033	COG2166	iron-sulfur cluster assembly
VCD_002034	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VCD_002035	COG0693	protein deglycase activity
VCD_002036	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VCD_002037	COG3248	Nucleoside-binding outer membrane protein
VCD_002039	COG1595	DNA-templated transcription, initiation
VCD_002041	COG2211	Major facilitator Superfamily
VCD_002042	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VCD_002044	COG2813	Specifically methylates the guanine in position
VCD_002045	COG0271	Belongs to the BolA IbaG family
VCD_002046	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VCD_002047	COG1805	sodium ion transport
VCD_002048	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VCD_002049	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VCD_002050	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VCD_002051	COG2871	sodium ion transport
VCD_002052	COG1477	protein flavinylation
VCD_002054	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VCD_002058	COG0733	neurotransmitter:sodium symporter activity
VCD_002060	COG0189	ligase activity
VCD_002061	COG4067	protein conserved in archaea
VCD_002061	COG0189	ligase activity
VCD_002062	COG2195	Cleaves the N-terminal amino acid of tripeptides
VCD_002064	COG2252	PERMEase
VCD_002065	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VCD_002068	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VCD_002069	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VCD_002070	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VCD_002071	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VCD_002071	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VCD_002074	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VCD_002075	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VCD_002076	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VCD_002077	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VCD_002079	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VCD_002080	COG0024	Methionine aminopeptidase
VCD_002081	COG0052	Belongs to the universal ribosomal protein uS2 family
VCD_002082	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VCD_002083	COG0528	UMP kinase activity
VCD_002084	COG0233	cytoplasmic translational termination
VCD_002085	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VCD_002086	COG0575	Belongs to the CDS family
VCD_002087	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VCD_002088	COG0750	zinc metalloprotease
VCD_002090	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VCD_002091	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VCD_002092	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VCD_002093	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VCD_002094	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VCD_002095	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VCD_002096	COG0587	DNA-directed DNA polymerase activity
VCD_002097	COG0825	malonyl-CoA metabolic process
VCD_002098	COG0037	tRNA processing
VCD_002100	COG3479	Phenolic acid decarboxylase
VCD_002101	COG0347	Belongs to the P(II) protein family
VCD_002103	COG1388	LysM domain
VCD_002103	COG0741	lytic transglycosylase activity
VCD_002104	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VCD_002105	COG2226	methyltransferase
VCD_002106	COG0328	RNA-DNA hybrid ribonuclease activity
VCD_002107	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VCD_002109	COG1960	acyl-CoA dehydrogenase activity
VCD_002110	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VCD_002111	COG0121	glutamine amidotransferase
VCD_002112	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VCD_002113	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VCD_002114	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VCD_002115	COG3706	GGDEF domain
VCD_002116	COG1187	pseudouridine synthase activity
VCD_002117	COG2840	Smr protein MutS2
VCD_002119	COG3735	TraB family
VCD_002123	COG2608	mercury ion transmembrane transporter activity
VCD_002123	COG2217	Heavy metal translocating P-type atpase
VCD_002124	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VCD_002127	COG1629	transport
VCD_002127	COG4774	siderophore transport
VCD_002128	COG2375	cellular response to nickel ion
VCD_002129	COG2226	methyltransferase
VCD_002129	COG3433	isochorismatase activity
VCD_002129	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VCD_002136	COG0784	Response regulator, receiver
VCD_002136	COG0835	chemotaxis
VCD_002137	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VCD_002138	COG1815	bacterial-type flagellum-dependent cell motility
VCD_002139	COG1558	bacterial-type flagellum-dependent cell motility
VCD_002140	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
VCD_002141	COG1749	Flagellar hook protein flgE
VCD_002142	COG4787	bacterial-type flagellum-dependent cell motility
VCD_002143	COG4786	Flagellar basal body rod
VCD_002144	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VCD_002145	COG1706	bacterial-type flagellum-dependent cell motility
VCD_002146	COG1705	Flagellar rod assembly protein muramidase FlgJ
VCD_002146	COG3951	Flagellar rod assembly protein muramidase FlgJ
VCD_002149	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VCD_002150	COG4974	Belongs to the 'phage' integrase family
VCD_002165	COG4695	Portal protein
VCD_002191	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VCD_002193	COG0012	GTP binding
VCD_002194	COG0193	aminoacyl-tRNA hydrolase activity
VCD_002195	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VCD_002196	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VCD_002197	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
VCD_002198	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VCD_002199	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VCD_002200	COG2890	protein-(glutamine-N5) methyltransferase activity
VCD_002201	COG3094	Invasion gene expression up-regulator, SirB
VCD_002202	COG2912	Transglutaminase-like superfamily
VCD_002203	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VCD_002204	COG0737	Belongs to the 5'-nucleotidase family
VCD_002205	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VCD_002206	COG2233	PERMEase
VCD_002210	COG1393	Belongs to the ArsC family
VCD_002211	COG4783	chaperone-mediated protein folding
VCD_002215	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VCD_002217	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VCD_002218	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VCD_002220	COG1876	peptidase activity
VCD_002221	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VCD_002222	COG1393	Belongs to the ArsC family
VCD_002226	COG2837	iron assimilation
VCD_002227	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VCD_002228	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VCD_002229	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VCD_002230	COG1334	flagellar protein FlaG
VCD_002231	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VCD_002233	COG1516	flagellar protein fliS
VCD_002234	COG2204	response regulator
VCD_002235	COG4191	Histidine kinase
VCD_002236	COG2204	response regulator
VCD_002237	COG1677	Flagellar hook-basal body complex protein FliE
VCD_002239	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VCD_002240	COG1317	bacterial-type flagellum organization
VCD_002244	COG1580	Controls the rotational direction of flagella during chemotaxis
VCD_002249	COG1987	bacterial-type flagellum assembly
VCD_002250	COG1684	flagellar biosynthetic protein fliR
VCD_002253	COG2890	protein-(glutamine-N5) methyltransferase activity
VCD_002254	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VCD_002255	COG2860	membrane
VCD_002256	COG3101	peptidyl-lysine hydroxylation
VCD_002258	COG0431	NADPH-dependent FMN reductase
VCD_002259	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VCD_002259	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VCD_002260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VCD_002261	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VCD_002262	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VCD_002263	COG0735	belongs to the Fur family
VCD_002265	COG0583	DNA-binding transcription factor activity
VCD_002267	COG1346	cytolysis
VCD_002270	COG0596	Alpha beta hydrolase
VCD_002271	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VCD_002272	COG0033	Phosphoglucomutase
VCD_002274	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VCD_002275	COG0372	Belongs to the citrate synthase family
VCD_002276	COG2009	succinate dehydrogenase
VCD_002277	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VCD_002278	COG1053	succinate dehydrogenase
VCD_002280	COG0567	Dehydrogenase, E1 component
VCD_002281	COG0508	dehydrogenase complex catalyzes the overall conversion of
VCD_002282	COG0045	succinate-CoA ligase (ADP-forming) activity
VCD_002284	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VCD_002285	COG1121	(ABC) transporter
VCD_002286	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VCD_002287	COG4977	sequence-specific DNA binding
VCD_002289	COG1918	ferrous iron import across plasma membrane
VCD_002293	COG0018	arginyl-trna synthetase
VCD_002295	COG1025	Belongs to the peptidase M16 family
VCD_002296	COG2062	phosphohistidine phosphatase, SixA
VCD_002299	COG0455	bacterial-type flagellum organization
VCD_002302	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VCD_002303	COG2198	Histidine kinase
VCD_002303	COG0643	Histidine kinase
VCD_002304	COG2201	protein-glutamate methylesterase activity
VCD_002305	COG1192	Involved in chromosome partitioning
VCD_002307	COG0835	chemotaxis
VCD_002309	COG4133	protoheme IX ABC transporter activity
VCD_002310	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VCD_002311	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VCD_002313	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VCD_002314	COG1138	Cytochrome C-type biogenesis protein
VCD_002315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VCD_002316	COG4235	cytochrome complex assembly
VCD_002316	COG3088	subunit of a heme lyase
VCD_002318	COG2853	Lipoprotein
VCD_002323	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VCD_002324	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VCD_002325	COG0123	including yeast histone deacetylase and acetoin utilization protein
VCD_002326	COG3083	sulfuric ester hydrolase activity
VCD_002328	COG3081	Nucleoid-associated protein
VCD_002330	COG1757	Na H antiporter
VCD_002331	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VCD_002332	COG2095	MarC family integral membrane protein
VCD_002334	COG1012	belongs to the aldehyde dehydrogenase family
VCD_002334	COG1454	alcohol dehydrogenase
VCD_002336	COG0659	secondary active sulfate transmembrane transporter activity
VCD_002337	COG1530	ribonuclease E activity
VCD_002339	COG0564	pseudouridine synthase activity
VCD_002340	COG0424	maF-like protein
VCD_002341	COG1399	metal-binding, possibly nucleic acid-binding protein
VCD_002342	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VCD_002343	COG0416	fatty acid biosynthetic process
VCD_002344	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VCD_002345	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
VCD_002346	COG1028	Short-chain dehydrogenase reductase Sdr
VCD_002347	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VCD_002348	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VCD_002349	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VCD_002350	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VCD_002351	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VCD_002353	COG0084	hydrolase, TatD family'
VCD_002354	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VCD_002354	COG1263	PTS System
VCD_002355	COG0733	neurotransmitter:sodium symporter activity
VCD_002358	COG4667	esterase of the alpha-beta hydrolase superfamily
VCD_002360	COG1940	carbohydrate kinase activity
VCD_002361	COG0784	Response regulator, receiver
VCD_002361	COG0835	chemotaxis
VCD_002364	COG2226	methyltransferase
VCD_002366	COG0676	glucose-6-phosphate 1-epimerase activity
VCD_002367	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VCD_002369	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VCD_002372	COG3139	Protein of unknown function (DUF1315)
VCD_002373	COG0252	asparaginase activity
VCD_002374	COG0616	signal peptide processing
VCD_002375	COG0446	pyridine nucleotide-disulphide oxidoreductase
VCD_002375	COG1902	pentaerythritol trinitrate reductase activity
VCD_002376	COG0788	formyltetrahydrofolate deformylase activity
VCD_002378	COG1199	ATP-dependent helicase activity
VCD_002379	COG1214	PFAM Peptidase M22, glycoprotease
VCD_002382	COG0596	Alpha beta hydrolase
VCD_002383	COG0318	PFAM AMP-dependent synthetase and ligase
VCD_002384	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VCD_002388	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VCD_002389	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VCD_002390	COG0436	Aminotransferase
VCD_002391	COG1169	isochorismate synthase
VCD_002392	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VCD_002393	COG0596	Alpha beta hydrolase
VCD_002395	COG1441	menaquinone biosynthetic process
VCD_002397	COG3135	benzoate transporter
VCD_002398	COG1396	sequence-specific DNA binding
VCD_002399	COG0840	transmembrane signaling receptor activity
VCD_002400	COG0477	Major facilitator Superfamily
VCD_002404	COG3015	lipoprotein NlpE involved in copper resistance
VCD_002405	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VCD_002406	COG2894	cell division
VCD_002407	COG0850	regulation of cytokinetic process
VCD_002408	COG3100	YcgL domain-containing protein
VCD_002409	COG2951	lytic endotransglycosylase activity
VCD_002411	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VCD_002412	COG3469	chitinase activity
VCD_002412	COG3325	Belongs to the glycosyl hydrolase 18 family
VCD_002413	COG3005	denitrification pathway
VCD_002414	COG0243	molybdopterin cofactor binding
VCD_002417	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VCD_002420	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VCD_002427	COG4589	Belongs to the CDS family
VCD_002429	COG3300	MHYT domain
VCD_002429	COG5001	Diguanylate cyclase
VCD_002432	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VCD_002434	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VCD_002435	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VCD_002436	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VCD_002438	COG4191	Histidine kinase
VCD_002439	COG0544	peptidyl-prolyl cis-trans isomerase activity
VCD_002441	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VCD_002442	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VCD_002443	COG0776	regulation of translation
VCD_002444	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VCD_002445	COG1555	photosystem II stabilization
VCD_002446	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VCD_002447	COG0539	negative regulation of cytoplasmic translation
VCD_002448	COG0776	regulation of translation
VCD_002449	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VCD_002450	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VCD_002451	COG0284	orotidine-5'-phosphate decarboxylase activity
VCD_002455	COG0583	DNA-binding transcription factor activity
VCD_002457	COG0686	Belongs to the AlaDH PNT family
VCD_002459	COG1674	ftsk spoiiie
VCD_002460	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VCD_002461	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VCD_002462	COG2186	Transcriptional regulator
VCD_002465	COG0537	adenosine 5'-monophosphoramidase activity
VCD_002471	COG1252	NADH dehydrogenase
VCD_002475	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VCD_002477	COG4591	ABC-type transport system involved in lipoprotein release permease component
VCD_002478	COG1136	(ABC) transporter
VCD_002479	COG4591	ABC-type transport system involved in lipoprotein release permease component
VCD_002482	COG2333	competence protein COMEC
VCD_002482	COG0658	competence protein
VCD_002483	COG1132	(ABC) transporter
VCD_002485	COG1663	tetraacyldisaccharide 4'-kinase activity
VCD_002487	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VCD_002488	COG2719	SpoVR family
VCD_002489	COG2718	Belongs to the UPF0229 family
VCD_002490	COG2766	serine protein kinase
VCD_002491	COG3013	Belongs to the UPF0304 family
VCD_002493	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VCD_002494	COG0840	transmembrane signaling receptor activity
VCD_002496	COG1882	Formate acetyltransferase
VCD_002500	COG4215	(ABC) transporter
VCD_002501	COG4160	amino acid transport
VCD_002502	COG0708	Exodeoxyribonuclease III
VCD_002509	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VCD_002511	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VCD_002514	COG3550	peptidyl-serine autophosphorylation
VCD_002517	COG0840	transmembrane signaling receptor activity
VCD_002519	COG3923	Primosomal replication protein n
VCD_002520	COG0730	response to heat
VCD_002521	COG1199	ATP-dependent helicase activity
VCD_002522	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VCD_002523	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VCD_002525	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VCD_002526	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VCD_002527	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VCD_002528	COG0215	cysteine-tRNA ligase activity
VCD_002529	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VCD_002530	COG0632	four-way junction helicase activity
VCD_002531	COG2255	four-way junction helicase activity
VCD_002532	COG1271	oxidase subunit
VCD_002533	COG1294	oxidase, subunit
VCD_002534	COG4890	Cyd operon protein YbgT
VCD_002535	COG3790	cyd operon protein YbgE
VCD_002537	COG0811	peptide transport
VCD_002540	COG0823	Involved in the tonB-independent uptake of proteins
VCD_002541	COG2885	chlorophyll binding
VCD_002543	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VCD_002545	COG0784	Response regulator, receiver
VCD_002545	COG5002	protein histidine kinase activity
VCD_002547	COG1482	cell wall glycoprotein biosynthetic process
VCD_002548	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCD_002548	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCD_002548	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCD_002549	COG2207	Transcriptional regulator
VCD_002551	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCD_002552	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCD_002553	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCD_002555	COG1012	belongs to the aldehyde dehydrogenase family
VCD_002557	COG3284	Transcriptional regulator
VCD_002558	COG4628	conserved protein (DUF2132)
VCD_002560	COG0415	Belongs to the DNA photolyase family
VCD_002573	COG0488	(ABC) transporter
VCD_002580	COG3941	tape measure
VCD_002585	COG2003	Belongs to the UPF0758 family
VCD_002587	COG4409	exo-alpha-(2->6)-sialidase activity
VCD_002588	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VCD_002589	COG1940	carbohydrate kinase activity
VCD_002590	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
VCD_002591	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VCD_002592	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VCD_002593	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VCD_002594	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VCD_002595	COG1737	Transcriptional regulator
VCD_002596	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
VCD_002597	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
VCD_002601	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VCD_002605	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VCD_002616	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VCD_002618	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VCD_002621	COG3550	peptidyl-serine autophosphorylation
VCD_002624	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VCD_002625	COG0582	viral genome integration into host DNA
VCD_002626	COG0582	viral genome integration into host DNA
VCD_002628	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCD_002630	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VCD_002630	COG3008	intermembrane lipid transfer
VCD_002631	COG2995	paraquat-inducible protein a
VCD_002632	COG0668	transmembrane transport
VCD_002636	COG1309	transcriptional regulator
VCD_002637	COG1012	belongs to the aldehyde dehydrogenase family
VCD_002642	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VCD_002643	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VCD_002644	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VCD_002645	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VCD_002647	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VCD_002649	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VCD_002651	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VCD_002652	COG0297	glycogen (starch) synthase activity
VCD_002657	COG3070	regulator of competence-specific genes
VCD_002658	COG1609	Transcriptional regulator
VCD_002659	COG3381	protein complex oligomerization
VCD_002660	COG0745	RESPONSE REGULATOR receiver
VCD_002661	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VCD_002662	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VCD_002663	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
VCD_002664	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VCD_002665	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VCD_002668	COG1032	radical SAM domain protein
VCD_002670	COG0612	Peptidase, M16
VCD_002673	COG0583	DNA-binding transcription factor activity
VCD_002674	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VCD_002676	COG2350	Protein conserved in bacteria
VCD_002677	COG1607	acyl-coa hydrolase
VCD_002678	COG2917	probably involved in intracellular septation
VCD_002680	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VCD_002681	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VCD_002683	COG2116	formate transmembrane transporter activity
VCD_002684	COG4459	periplasmic nitrate reductase
VCD_002685	COG3005	denitrification pathway
VCD_002686	COG0243	molybdopterin cofactor binding
VCD_002690	COG1227	inorganic diphosphatase activity
VCD_002693	COG4172	Belongs to the ABC transporter superfamily
VCD_002695	COG4171	peptide transport system, permease
VCD_002696	COG4168	peptide transport system, permease
VCD_002698	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VCD_002699	COG1842	Phage shock protein A
VCD_002702	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCD_002705	COG2818	Glycosylase
VCD_002706	COG0626	cystathionine gamma-synthase activity
VCD_002708	COG0733	neurotransmitter:sodium symporter activity
VCD_002710	COG0564	pseudouridine synthase activity
VCD_002711	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VCD_002712	COG4136	ATPase activity
VCD_002713	COG4135	transport system, permease component
VCD_002714	COG4134	Bacterial extracellular solute-binding protein
VCD_002716	COG3313	Fe-S protein
VCD_002718	COG0842	Transport permease protein
VCD_002719	COG1131	(ABC) transporter
VCD_002720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCD_002721	COG0814	amino acid
VCD_002723	COG2239	Acts as a magnesium transporter
VCD_002727	COG4934	collagen metabolic process
VCD_002732	COG0840	transmembrane signaling receptor activity
VCD_002734	COG3706	GGDEF domain
VCD_002734	COG2203	Gaf domain
VCD_002734	COG4251	negative regulation of phosphorylation
VCD_002734	COG5001	Diguanylate cyclase
VCD_002735	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VCD_002739	COG1061	Type III restriction enzyme res subunit
VCD_002740	COG1187	pseudouridine synthase activity
VCD_002741	COG2814	Major facilitator Superfamily
VCD_002743	COG0702	epimerase
VCD_002744	COG0534	Mate efflux family protein
VCD_002745	COG4181	ATPase activity
VCD_002748	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VCD_002749	COG0076	glutamate decarboxylase activity
VCD_002750	COG1748	Saccharopine dehydrogenase
VCD_002752	COG0019	diaminopimelate decarboxylase activity
VCD_002754	COG1538	Outer membrane efflux protein
VCD_002759	COG0583	DNA-binding transcription factor activity
VCD_002761	COG1451	nucleotide metabolic process
VCD_002762	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
VCD_002764	COG3063	Type IV pilus biogenesis stability protein PilW
VCD_002765	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
VCD_002769	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCD_002771	COG3290	protein histidine kinase activity
VCD_002772	COG4565	transcriptional regulatory protein
VCD_002774	COG0835	chemotaxis
VCD_002774	COG0784	Response regulator, receiver
VCD_002777	COG3706	GGDEF domain
VCD_002777	COG0745	RESPONSE REGULATOR receiver
VCD_002780	COG1085	galactose-1-phosphate uridylyltransferase
VCD_002781	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VCD_002782	COG2017	converts alpha-aldose to the beta-anomer
VCD_002783	COG3706	GGDEF domain
VCD_002784	COG2200	EAL domain
VCD_002784	COG2199	diguanylate cyclase activity
VCD_002792	COG0753	catalase activity
VCD_002796	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VCD_002798	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VCD_002806	COG1271	oxidase subunit
VCD_002807	COG1294	oxidase, subunit
VCD_002808	COG1136	(ABC) transporter
VCD_002808	COG4591	ABC-type transport system involved in lipoprotein release permease component
VCD_002809	COG1136	(ABC) transporter
VCD_002809	COG0577	efflux transmembrane transporter activity
VCD_002810	COG0577	efflux transmembrane transporter activity
VCD_002810	COG1136	(ABC) transporter
VCD_002814	COG0583	DNA-binding transcription factor activity
VCD_002815	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
VCD_002817	COG2723	6-phospho-beta-galactosidase activity
VCD_002818	COG1609	Transcriptional regulator
VCD_002819	COG0251	oxidation-reduction process
VCD_002820	COG2731	YhcH YjgK YiaL family protein
VCD_002821	COG0584	glycerophosphoryl diester phosphodiesterase
VCD_002822	COG1349	DNA-binding transcription factor activity
VCD_002823	COG3842	ATPase activity
VCD_002824	COG0395	ABC-type sugar transport system, permease component
VCD_002825	COG1175	transmembrane transport
VCD_002828	COG0811	peptide transport
VCD_002829	COG0811	peptide transport
VCD_002830	COG0848	biopolymer transport protein
VCD_002831	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VCD_002833	COG1793	dna ligase
VCD_002835	COG0534	Mate efflux family protein
VCD_002839	COG0791	NLP P60 protein
VCD_002840	COG0840	transmembrane signaling receptor activity
VCD_002844	COG1940	carbohydrate kinase activity
VCD_002849	COG0746	molybdenum cofactor guanylyltransferase activity
VCD_002850	COG3842	ATPase activity
VCD_002851	COG4662	Binding-protein-dependent transport system inner membrane component
VCD_002853	COG2204	response regulator
VCD_002854	COG3852	Histidine kinase
VCD_002855	COG0488	(ABC) transporter
VCD_002856	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VCD_002862	COG3383	formate dehydrogenase (NAD+) activity
VCD_002862	COG0243	molybdopterin cofactor binding
VCD_002863	COG0437	4 iron, 4 sulfur cluster binding
VCD_002866	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VCD_002868	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VCD_002871	COG2996	Protein conserved in bacteria
VCD_002872	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VCD_002872	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
VCD_002873	COG3008	intermembrane lipid transfer
VCD_002874	COG2995	paraquat-inducible protein a
VCD_002875	COG1132	(ABC) transporter
VCD_002876	COG1956	GAF domain-containing protein
VCD_002877	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VCD_002880	COG0308	aminopeptidase N
VCD_002883	COG0167	dihydroorotate dehydrogenase activity
VCD_002885	COG0116	Belongs to the methyltransferase superfamily
VCD_002885	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VCD_002890	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VCD_002891	COG1067	ATP-dependent peptidase activity
VCD_002892	COG3120	sequence-specific DNA binding
VCD_002895	COG1073	alpha beta
VCD_002895	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
VCD_002895	COG3064	Membrane
VCD_002896	COG2994	toxin metabolic process
VCD_002901	COG2205	protein histidine kinase activity
VCD_002901	COG0784	Response regulator, receiver
VCD_002904	COG3278	Belongs to the heme-copper respiratory oxidase family
VCD_002907	COG2010	Cytochrome c
VCD_002909	COG2217	Heavy metal translocating P-type atpase
VCD_002912	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VCD_002913	COG0589	response to stress
VCD_002914	COG0037	tRNA processing
VCD_002918	COG3842	ATPase activity
VCD_002919	COG1176	ABC-type spermidine putrescine transport system, permease component I
VCD_002920	COG1177	transmembrane transport
VCD_002921	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VCD_002922	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VCD_002925	COG1115	amino acid carrier protein
VCD_002926	COG1280	lysine exporter protein (LysE YggA)
VCD_002931	COG3501	Rhs element vgr protein
VCD_002933	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VCD_002934	COG0840	transmembrane signaling receptor activity
VCD_002935	COG2814	Major facilitator Superfamily
VCD_002936	COG1566	PFAM secretion protein HlyD family protein
VCD_002937	COG1538	Outer membrane efflux protein
VCD_002939	COG0513	Belongs to the DEAD box helicase family
VCD_002941	COG0840	transmembrane signaling receptor activity
VCD_002942	COG0840	transmembrane signaling receptor activity
VCD_002942	COG3290	protein histidine kinase activity
VCD_002943	COG0835	chemotaxis
VCD_002944	COG2201	protein-glutamate methylesterase activity
VCD_002946	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VCD_002948	COG2198	Histidine kinase
VCD_002948	COG0643	Histidine kinase
VCD_002952	COG2076	Multidrug Resistance protein
VCD_002953	COG0415	Belongs to the DNA photolyase family
VCD_002954	COG0477	Major facilitator Superfamily
VCD_002955	COG0583	DNA-binding transcription factor activity
VCD_002957	COG0095	Lipoate-protein ligase
VCD_002959	COG0443	Heat shock 70 kDa protein
VCD_002961	COG1643	Atp-dependent helicase
VCD_002967	COG0443	Heat shock 70 kDa protein
VCD_002968	COG0443	Heat shock 70 kDa protein
VCD_002969	COG3706	GGDEF domain
VCD_002975	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VCD_002976	COG0602	queuosine metabolic process
VCD_002977	COG0561	phosphatase activity
VCD_002979	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VCD_002980	COG4597	amino acid ABC transporter
VCD_002981	COG0765	amino acid transport
VCD_002982	COG1126	abc transporter atp-binding protein
VCD_002983	COG0670	Belongs to the BI1 family
VCD_002984	COG2920	part of a sulfur-relay system
VCD_002985	COG1254	Belongs to the acylphosphatase family
VCD_002986	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VCD_002987	COG3706	GGDEF domain
VCD_002991	COG3437	response regulator, receiver
VCD_002992	COG0625	glutathione transferase activity
VCD_002994	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VCD_002996	COG2195	Cleaves the N-terminal amino acid of tripeptides
VCD_003002	COG0372	Belongs to the citrate synthase family
VCD_003003	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VCD_003004	COG2186	Transcriptional regulator
VCD_003011	COG1129	ABC transporter
VCD_003016	COG0745	RESPONSE REGULATOR receiver
VCD_003017	COG2205	protein histidine kinase activity
VCD_003018	COG3713	MltA-interacting MipA family protein
VCD_003019	COG2990	Protein conserved in bacteria
VCD_003021	COG4191	Histidine kinase
VCD_003021	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VCD_003022	COG0471	metal ion transport
VCD_003024	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VCD_003027	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VCD_003028	COG3283	Transcriptional regulator of aromatic amino acids metabolism
VCD_003029	COG3768	UPF0283 membrane protein
VCD_003030	COG3106	COG3106 Predicted ATPase
VCD_003033	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VCD_003034	COG0494	nUDIX hydrolase
VCD_003035	COG0814	amino acid
VCD_003036	COG1760	l-serine dehydratase
VCD_003037	COG0720	synthase
VCD_003044	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VCD_003046	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VCD_003049	COG3550	peptidyl-serine autophosphorylation
VCD_003054	COG0017	Asparaginyl-tRNA synthetase
VCD_003055	COG0351	phosphomethylpyrimidine kinase
VCD_003056	COG2770	Histidine kinase
VCD_003056	COG3437	response regulator, receiver
VCD_003058	COG1448	Aminotransferase
VCD_003061	COG0840	transmembrane signaling receptor activity
VCD_003062	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
VCD_003063	COG2943	transferase activity, transferring hexosyl groups
VCD_003064	COG1609	Transcriptional regulator
VCD_003065	COG3394	polysaccharide catabolic process
VCD_003066	COG1486	melibiose metabolic process
VCD_003067	COG1447	Phosphotransferase system cellobiose-specific component IIA
VCD_003069	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VCD_003070	COG0726	polysaccharide deacetylase
VCD_003071	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VCD_003072	COG1846	Transcriptional regulator
VCD_003078	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VCD_003081	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VCD_003082	COG3108	Peptidase M15
VCD_003083	COG2989	Protein conserved in bacteria
VCD_003088	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VCD_003090	COG2814	Major facilitator Superfamily
VCD_003094	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VCD_003095	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VCD_003096	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VCD_003105	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
VCD_003106	COG4139	cobalamin transport
VCD_003107	COG2988	succinylglutamate desuccinylase activity
VCD_003110	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VCD_003111	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VCD_003113	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VCD_003115	COG2925	Exonuclease
VCD_003117	COG1346	cytolysis
VCD_003118	COG0295	cytidine deaminase activity
VCD_003121	COG0500	methyltransferase
VCD_003123	COG0776	regulation of translation
VCD_003125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VCD_003125	COG0072	phenylalanine-tRNA ligase activity
VCD_003126	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VCD_003128	COG3706	GGDEF domain
VCD_003128	COG0745	RESPONSE REGULATOR receiver
VCD_003130	COG0322	excinuclease ABC activity
VCD_003131	COG2197	response regulator
VCD_003132	COG0417	DNA replication proofreading
VCD_003133	COG5001	Diguanylate cyclase
VCD_003135	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VCD_003139	COG1228	amidohydrolase
VCD_003140	COG0010	Belongs to the arginase family
VCD_003141	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VCD_003142	COG2986	histidine ammonia-lyase
VCD_003146	COG0277	FAD linked oxidase domain protein
VCD_003146	COG0247	lactate metabolic process
VCD_003149	COG2885	chlorophyll binding
VCD_003153	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VCD_003155	COG0281	malic enzyme
VCD_003157	COG2949	membrane
VCD_003158	COG3706	GGDEF domain
VCD_003159	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VCD_003161	COG0492	ferredoxin-NADP+ reductase activity
VCD_003162	COG4988	ABC transporter
VCD_003163	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VCD_003164	COG1187	pseudouridine synthase activity
VCD_003165	COG0009	L-threonylcarbamoyladenylate synthase
VCD_003166	COG0613	PHP domain protein
VCD_003169	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VCD_003170	COG0512	Glutamine amidotransferase of anthranilate synthase
VCD_003171	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VCD_003172	COG0134	indole-3-glycerol-phosphate synthase activity
VCD_003172	COG0135	phosphoribosylanthranilate isomerase activity
VCD_003173	COG0133	tryptophan synthase activity
VCD_003174	COG0159	tryptophan synthase activity
VCD_003176	COG1435	thymidine kinase activity
VCD_003177	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VCD_003178	COG1801	Protein of unknown function DUF72
VCD_003179	COG4106	trans-aconitate 2-methyltransferase activity
VCD_003180	COG0500	methyltransferase
VCD_003181	COG0189	ligase activity
VCD_003181	COG4067	protein conserved in archaea
VCD_003184	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VCD_003186	COG3852	Histidine kinase
VCD_003189	COG3070	regulator of competence-specific genes
VCD_003191	COG2431	L-lysine efflux transmembrane transporter activity
VCD_003193	COG0076	glutamate decarboxylase activity
VCD_003194	COG1737	Transcriptional regulator
VCD_003195	COG1012	belongs to the aldehyde dehydrogenase family
VCD_003195	COG1454	alcohol dehydrogenase
VCD_003196	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VCD_003198	COG0542	response to heat
VCD_003199	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VCD_003200	COG1278	Cold shock
VCD_003202	COG1187	pseudouridine synthase activity
VCD_003203	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VCD_003203	COG0140	phosphoribosyl-ATP diphosphatase activity
VCD_003204	COG0107	imidazoleglycerol-phosphate synthase activity
VCD_003205	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VCD_003206	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VCD_003207	COG0131	Imidazoleglycerol-phosphate dehydratase
VCD_003207	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VCD_003208	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VCD_003209	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VCD_003210	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VCD_003211	COG1757	Na H antiporter
VCD_003212	COG2916	Histone family protein nucleoid-structuring protein H-NS
VCD_003213	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VCD_003214	COG0482	sulfurtransferase activity
VCD_003215	COG2915	High frequency lysogenization protein hflD homolog
VCD_003216	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VCD_003218	COG2268	Band 7 protein
VCD_003220	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VCD_003223	COG0300	oxidoreductase activity
VCD_003225	COG0501	Belongs to the peptidase M48B family
VCD_003227	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VCD_003228	COG2226	methyltransferase
VCD_003229	COG0156	8-amino-7-oxononanoate synthase activity
VCD_003230	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VCD_003231	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VCD_003232	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VCD_003233	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VCD_003234	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VCD_003236	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VCD_003237	COG2203	Gaf domain
VCD_003237	COG2199	diguanylate cyclase activity
VCD_003239	COG4120	Belongs to the binding-protein-dependent transport system permease family
VCD_003241	COG4628	conserved protein (DUF2132)
VCD_003242	COG3092	negative regulation of chromosome organization
VCD_003243	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VCD_003244	COG0280	phosphate acetyltransferase
VCD_003244	COG0857	belongs to the CobB CobQ family
VCD_003245	COG0435	Glutathione S-transferase
VCD_003246	COG4608	Belongs to the ABC transporter superfamily
VCD_003247	COG0444	Belongs to the ABC transporter superfamily
VCD_003248	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VCD_003249	COG0601	transmembrane transport
VCD_003253	COG2204	response regulator
VCD_003254	COG5001	Diguanylate cyclase
VCD_003254	COG3300	MHYT domain
VCD_003255	COG4191	Histidine kinase
VCD_003256	COG5002	protein histidine kinase activity
VCD_003258	COG2201	protein-glutamate methylesterase activity
VCD_003261	COG0009	L-threonylcarbamoyladenylate synthase
VCD_003266	COG1881	PFAM PEBP family protein
VCD_003271	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VCD_003272	COG0640	Transcriptional regulator
VCD_003274	COG3706	GGDEF domain
VCD_003279	COG1946	Acyl-CoA thioesterase
VCD_003280	COG1522	sequence-specific DNA binding
VCD_003282	COG0616	signal peptide processing
VCD_003283	COG1028	Short-chain dehydrogenase reductase Sdr
VCD_003286	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VCD_003287	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VCD_003289	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VCD_003290	COG2832	Protein of unknown function (DUF454)
VCD_003292	COG0745	RESPONSE REGULATOR receiver
VCD_003293	COG0583	DNA-binding transcription factor activity
VCD_003294	COG0778	Nitroreductase
VCD_003295	COG1024	Enoyl-CoA hydratase
VCD_003295	COG1250	3-hydroxyacyl-CoA dehydrogenase
VCD_003296	COG0183	Belongs to the thiolase family
VCD_003299	COG2067	long-chain fatty acid transport protein
VCD_003301	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VCD_003302	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VCD_003303	COG2982	Protein involved in outer membrane biogenesis
VCD_003304	COG0572	uridine kinase
VCD_003305	COG0489	protein tyrosine kinase activity
VCD_003306	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VCD_003306	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VCD_003308	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VCD_003310	COG4109	DRTGG domain
VCD_003311	COG2199	diguanylate cyclase activity
VCD_003312	COG0314	molybdopterin synthase activity
VCD_003313	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VCD_003314	COG0315	cyclic pyranopterin monophosphate synthase activity
VCD_003315	COG0521	Mo-molybdopterin cofactor biosynthetic process
VCD_003316	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VCD_003317	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VCD_003318	COG2198	Histidine kinase
VCD_003319	COG2204	response regulator
VCD_003320	COG0556	nucleotide-excision repair
VCD_003321	COG4657	Part of a membrane complex involved in electron transport
VCD_003322	COG2878	Part of a membrane complex involved in electron transport
VCD_003323	COG4656	Part of a membrane complex involved in electron transport
VCD_003324	COG4658	electron transport chain
VCD_003325	COG4659	FMN binding
VCD_003326	COG4660	Part of a membrane complex involved in electron transport
VCD_003327	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VCD_003328	COG0346	lactoylglutathione lyase activity
VCD_003332	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VCD_003333	COG2056	Na+-H+ antiporter family
VCD_003334	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VCD_003335	COG1286	toxin biosynthetic process
VCD_003336	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VCD_003337	COG0285	dihydrofolate synthase activity
VCD_003338	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VCD_003339	COG0101	tRNA pseudouridine synthase activity
VCD_003341	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VCD_003343	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VCD_003343	COG1263	PTS System
VCD_003343	COG2190	(PTS) system
VCD_003344	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VCD_003345	COG1846	Transcriptional regulator
VCD_003345	COG1940	carbohydrate kinase activity
VCD_003346	COG4651	solute:proton antiporter activity
VCD_003346	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VCD_003347	COG0367	asparagine synthase
VCD_003351	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VCD_003352	COG0563	adenylate kinase activity
VCD_003353	COG0326	Molecular chaperone. Has ATPase activity
VCD_003354	COG3710	Transcriptional regulator
VCD_003357	COG0622	Phosphoesterase
VCD_003358	COG1090	epimerase
VCD_003359	COG0300	oxidoreductase activity
VCD_003361	COG3118	belongs to the thioredoxin family
VCD_003362	COG0330	HflC and HflK could
VCD_003363	COG1585	Membrane protein implicated in regulation of membrane protease activity
VCD_003364	COG0789	Transcriptional regulator
VCD_003367	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VCD_003368	COG3115	cell septum assembly
VCD_003369	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VCD_003370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VCD_003371	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCD_003373	COG2190	(PTS) system
VCD_003374	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VCD_003375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VCD_003376	COG1702	phosphate starvation-inducible protein PhoH
VCD_003377	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VCD_003378	COG4535	Mg2 and Co2 transporter CorC
VCD_003379	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VCD_003380	COG2888	peptidyl-tyrosine sulfation
VCD_003381	COG0495	leucyl-tRNA aminoacylation
VCD_003382	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VCD_003383	COG1466	dna polymerase III delta subunit
VCD_003384	COG0799	negative regulation of ribosome biogenesis
VCD_003385	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VCD_003386	COG0768	penicillin binding
VCD_003387	COG0772	Belongs to the SEDS family
VCD_003388	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VCD_003389	COG1686	Belongs to the peptidase S11 family
VCD_003390	COG2921	Belongs to the UPF0250 family
VCD_003391	COG0321	lipoyl(octanoyl) transferase activity
VCD_003392	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VCD_003394	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VCD_003399	COG1596	polysaccharide export
VCD_003401	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VCD_003407	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
VCD_003409	COG0438	transferase activity, transferring glycosyl groups
VCD_003411	COG1045	serine acetyltransferase
VCD_003415	COG0110	maltose O-acetyltransferase activity
VCD_003416	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VCD_003417	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VCD_003418	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VCD_003419	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VCD_003421	COG0366	Alpha amylase catalytic
VCD_003422	COG1263	PTS System
VCD_003422	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VCD_003423	COG1609	Transcriptional regulator
VCD_003424	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VCD_003425	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VCD_003426	COG2011	ABC-type metal ion transport system permease component
VCD_003427	COG1464	Belongs to the NlpA lipoprotein family
VCD_003428	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VCD_003430	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VCD_003430	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VCD_003432	COG3706	GGDEF domain
VCD_003433	COG1611	Belongs to the LOG family
VCD_003434	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VCD_003435	COG2363	Small membrane protein
VCD_003436	COG0583	DNA-binding transcription factor activity
VCD_003437	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VCD_003437	COG0301	tRNA thio-modification
VCD_003440	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VCD_003441	COG1722	exodeoxyribonuclease VII activity
VCD_003442	COG0142	geranyltranstransferase activity
VCD_003443	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VCD_003444	COG0564	pseudouridine synthase activity
VCD_003445	COG3098	single-species biofilm formation
VCD_003448	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VCD_003450	COG1671	Belongs to the UPF0178 family
VCD_003451	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VCD_003452	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VCD_003453	COG0254	rRNA binding
VCD_003454	COG1720	tRNA m6t6A37 methyltransferase activity
VCD_003455	COG0442	prolyl-tRNA aminoacylation
VCD_003459	COG1943	Transposase
VCD_003460	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VCD_003460	COG0047	phosphoribosylformylglycinamidine synthase activity
VCD_003462	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VCD_003463	COG0590	tRNA wobble adenosine to inosine editing
VCD_003464	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VCD_003471	COG0484	heat shock protein binding
VCD_003472	COG0443	Heat shock 70 kDa protein
VCD_003474	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VCD_003475	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VCD_003476	COG0497	DNA recombination
VCD_003477	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VCD_003478	COG2914	Belongs to the UPF0125 (RnfH) family
VCD_003479	COG2867	negative regulation of translational initiation
VCD_003480	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VCD_003484	COG3064	Membrane
VCD_003486	COG0739	heme binding
VCD_003489	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
VCD_003490	COG2207	Transcriptional regulator
VCD_003492	COG1459	type II secretion system
VCD_003493	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VCD_003497	COG4796	Type ii and iii secretion system protein
VCD_003500	COG2165	general secretion pathway protein
VCD_003502	COG3710	Transcriptional regulator
VCD_003503	COG0840	transmembrane signaling receptor activity
VCD_003504	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
VCD_003508	COG1012	belongs to the aldehyde dehydrogenase family
VCD_003519	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VCD_003521	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VCD_003522	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VCD_003524	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
VCD_003525	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
VCD_003526	COG3051	citrate lyase alpha subunit
VCD_003527	COG2301	Belongs to the HpcH HpaI aldolase family
VCD_003528	COG3052	prosthetic group binding
VCD_003529	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
VCD_003531	COG3630	sodium ion export across plasma membrane
VCD_003532	COG5016	pyruvate
VCD_003532	COG0511	ligase activity, forming carbon-carbon bonds
VCD_003533	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VCD_003536	COG4565	transcriptional regulatory protein
VCD_003539	COG0583	DNA-binding transcription factor activity
VCD_003540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VCD_003542	COG1115	amino acid carrier protein
VCD_003543	COG2015	COG2015, Alkyl sulfatase and related hydrolases
VCD_003544	COG0583	DNA-binding transcription factor activity
VCD_003546	COG1120	ATPase activity
VCD_003548	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VCD_003549	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VCD_003550	COG4592	Periplasmic binding protein
VCD_003552	COG1028	Short-chain dehydrogenase reductase Sdr
VCD_003553	COG1169	isochorismate synthase
VCD_003554	COG1021	2,3-dihydroxybenzoate-AMP ligase
VCD_003555	COG1535	isochorismatase
VCD_003555	COG3433	isochorismatase activity
VCD_003556	COG1584	GPR1 FUN34 yaaH family protein
VCD_003558	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VCD_003558	COG0519	Catalyzes the synthesis of GMP from XMP
VCD_003559	COG0517	IMP dehydrogenase activity
VCD_003559	COG0516	GMP reductase activity
VCD_003560	COG1570	exodeoxyribonuclease VII activity
VCD_003563	COG1160	GTP binding
VCD_003564	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VCD_003565	COG2976	Protein conserved in bacteria
VCD_003566	COG0124	histidyl-tRNA synthetase
VCD_003567	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VCD_003569	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VCD_003570	COG0105	UTP biosynthetic process
VCD_003571	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VCD_003572	COG2975	iron-sulfur cluster assembly
VCD_003573	COG0633	Ferredoxin
VCD_003574	COG0443	Heat shock 70 kDa protein
VCD_003575	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VCD_003577	COG0822	iron-sulfur transferase activity
VCD_003578	COG1104	cysteine desulfurase activity
VCD_003579	COG1959	2 iron, 2 sulfur cluster binding
VCD_003581	COG0483	inositol monophosphate 1-phosphatase activity
VCD_003582	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VCD_003583	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VCD_003584	COG1862	Preprotein translocase
VCD_003585	COG0343	queuine tRNA-ribosyltransferase activity
VCD_003586	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VCD_003588	COG0517	IMP dehydrogenase activity
VCD_003591	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VCD_003592	COG0583	DNA-binding transcription factor activity
VCD_003593	COG0450	alkyl hydroperoxide reductase
VCD_003594	COG3142	Participates in the control of copper homeostasis
VCD_003598	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VCD_003599	COG0581	inorganic phosphate transmembrane transporter activity
VCD_003601	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VCD_003602	COG0248	Ppx GppA phosphatase
VCD_003604	COG5002	protein histidine kinase activity
VCD_003605	COG0745	RESPONSE REGULATOR receiver
VCD_003606	COG2974	May be involved in recombination
VCD_003608	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VCD_003611	COG0542	response to heat
VCD_003613	COG0564	pseudouridine synthase activity
VCD_003614	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VCD_003616	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VCD_003617	COG1605	Chorismate mutase
VCD_003617	COG0077	Prephenate dehydratase
VCD_003618	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VCD_003619	COG5001	Diguanylate cyclase
VCD_003620	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VCD_003621	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VCD_003623	COG0488	(ABC) transporter
VCD_003625	COG0287	Prephenate dehydrogenase
VCD_003625	COG1605	Chorismate mutase
VCD_003626	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VCD_003627	COG3275	phosphorelay sensor kinase activity
VCD_003628	COG3279	Response regulator of the LytR AlgR family
VCD_003629	COG1472	Belongs to the glycosyl hydrolase 3 family
VCD_003630	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VCD_003631	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VCD_003634	COG1966	Carbon starvation protein
VCD_003635	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VCD_003636	COG1047	Peptidyl-prolyl cis-trans
VCD_003637	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VCD_003638	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VCD_003639	COG0196	riboflavin kinase activity
VCD_003640	COG0728	peptidoglycan biosynthetic process
VCD_003641	COG0268	Binds directly to 16S ribosomal RNA
VCD_003642	COG0640	Transcriptional regulator
VCD_003643	COG0583	DNA-binding transcription factor activity
VCD_003645	COG1283	sodium-dependent phosphate transmembrane transporter activity
VCD_003646	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VCD_003647	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VCD_003648	COG0730	response to heat
VCD_003649	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
VCD_003650	COG0494	nUDIX hydrolase
VCD_003651	COG3066	DNA modification
VCD_003652	COG0667	Aldo Keto reductase
VCD_003654	COG2204	response regulator
VCD_003655	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VCD_003656	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VCD_003658	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VCD_003659	COG0513	Belongs to the DEAD box helicase family
VCD_003660	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VCD_003677	COG2003	Belongs to the UPF0758 family
VCD_003682	COG0714	Associated with various cellular activities
VCD_003686	COG0629	single-stranded DNA binding
VCD_003694	COG0681	Belongs to the peptidase S26 family
VCD_003697	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VCD_003698	COG2204	response regulator
VCD_003715	COG1196	nuclear chromosome segregation
VCD_003726	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VCD_003734	COG1230	cation diffusion facilitator family transporter
VCD_003752	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VCD_003756	COG3153	acetyltransferase
VCD_003763	COG4785	May be involved in cell division
VCD_003764	COG1185	polyribonucleotide nucleotidyltransferase activity
VCD_003765	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VCD_003766	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VCD_003767	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VCD_003768	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VCD_003769	COG0195	Participates in both transcription termination and antitermination
VCD_003770	COG0779	Required for maturation of 30S ribosomal subunits
VCD_003771	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VCD_003772	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VCD_003773	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VCD_003774	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VCD_003775	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VCD_003776	COG1534	Rna-binding protein
VCD_003777	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VCD_003778	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VCD_003779	COG2027	D-alanyl-D-alanine carboxypeptidase
VCD_003780	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VCD_003781	COG0739	heme binding
VCD_003784	COG0316	Belongs to the HesB IscA family
VCD_003785	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VCD_003786	COG0628	permease
VCD_003787	COG2813	Specifically methylates the guanine in position
VCD_003789	COG0747	negative chemotaxis
VCD_003790	COG0601	transmembrane transport
VCD_003791	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VCD_003792	COG0444	Belongs to the ABC transporter superfamily
VCD_003793	COG4608	Belongs to the ABC transporter superfamily
VCD_003795	COG2971	BadF BadG BcrA BcrD
VCD_003799	COG3842	ATPase activity
VCD_003801	COG1840	ABC-type Fe3 transport system, periplasmic component
VCD_003802	COG0004	ammonium transporteR
VCD_003803	COG0347	Belongs to the P(II) protein family
VCD_003804	COG3112	Uncharacterised protein family (UPF0231)
VCD_003805	COG1049	propionate catabolic process, 2-methylcitrate cycle
VCD_003806	COG1752	Esterase of the alpha-beta hydrolase superfamily
VCD_003807	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VCD_003808	COG1643	Atp-dependent helicase
VCD_003810	COG1489	DNA binding
VCD_003811	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VCD_003812	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VCD_003814	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase