locus-tag	class	description
KAF59_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KAF59_00010	COG0592	DNA-directed DNA polymerase activity
KAF59_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KAF59_00020	COG0187	DNA topoisomerase II activity
KAF59_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
KAF59_00035	COG3977	Valine--pyruvate aminotransferase
KAF59_00040	COG0751	glycine-tRNA ligase activity
KAF59_00045	COG0752	glycyl-tRNA synthetase alpha subunit
KAF59_00050	COG2119	membrane
KAF59_00060	COG0425	Belongs to the sulfur carrier protein TusA family
KAF59_00070	COG0604	alcohol dehydrogenase
KAF59_00080	COG0129	dihydroxy-acid dehydratase activity
KAF59_00085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KAF59_00100	COG0606	chelatase, subunit chli
KAF59_00105	COG0204	Acyl-transferase
KAF59_00110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KAF59_00115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KAF59_00125	COG3084	Protein conserved in bacteria
KAF59_00130	COG4326	sporulation control protein
KAF59_00135	COG1272	protein, Hemolysin III
KAF59_00145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KAF59_00150	COG0569	domain protein
KAF59_00155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KAF59_00155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KAF59_00160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KAF59_00165	COG0242	peptide deformylase activity
KAF59_00170	COG1652	LysM domain
KAF59_00175	COG0758	DNA mediated transformation
KAF59_00180	COG2922	Belongs to the Smg family
KAF59_00185	COG0551	DNA topoisomerase type I activity
KAF59_00190	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KAF59_00195	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KAF59_00200	COG0009	L-threonylcarbamoyladenylate synthase
KAF59_00205	COG0408	coproporphyrinogen oxidase activity
KAF59_00210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KAF59_00220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KAF59_00260	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KAF59_00265	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KAF59_00275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KAF59_00280	COG2104	thiamine diphosphate biosynthetic process
KAF59_00285	COG2022	thiamine diphosphate biosynthetic process
KAF59_00290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KAF59_00295	COG0006	proline dipeptidase activity
KAF59_00295	COG0006	proline dipeptidase activity
KAF59_00315	COG1522	sequence-specific DNA binding
KAF59_00320	COG5002	protein histidine kinase activity
KAF59_00320	COG5001	Diguanylate cyclase
KAF59_00340	COG0589	response to stress
KAF59_00345	COG1528	Iron-storage protein
KAF59_00355	COG2081	HI0933 family
KAF59_00365	COG1322	Protein conserved in bacteria
KAF59_00370	COG2226	methyltransferase
KAF59_00385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KAF59_00390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KAF59_00395	COG0805	protein transport
KAF59_00400	COG1858	cytochrome C peroxidase
KAF59_00405	COG0534	Mate efflux family protein
KAF59_00415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KAF59_00425	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KAF59_00430	COG3161	chorismate lyase activity
KAF59_00435	COG1580	Controls the rotational direction of flagella during chemotaxis
KAF59_00440	COG0840	transmembrane signaling receptor activity
KAF59_00450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KAF59_00455	COG0084	hydrolase, TatD family'
KAF59_00470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KAF59_00470	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KAF59_00490	COG3078	GTPase activator activity
KAF59_00505	COG3071	HemY protein
KAF59_00510	COG2959	enzyme of heme biosynthesis
KAF59_00515	COG1587	Uroporphyrinogen-III synthase
KAF59_00520	COG0181	hydroxymethylbilane synthase activity
KAF59_00530	COG1965	Belongs to the frataxin family
KAF59_00540	COG0019	diaminopimelate decarboxylase activity
KAF59_00545	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KAF59_00555	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
KAF59_00560	COG1011	Hydrolase
KAF59_00565	COG3287	FIST C domain
KAF59_00565	COG2199	diguanylate cyclase activity
KAF59_00565	COG2200	EAL domain
KAF59_00580	COG0561	phosphatase activity
KAF59_00585	COG2267	carboxylic ester hydrolase activity
KAF59_00590	COG1280	lysine exporter protein (LysE YggA)
KAF59_00595	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
KAF59_00600	COG0783	Belongs to the Dps family
KAF59_00630	COG0742	ribosomal rna small subunit methyltransferase
KAF59_00635	COG0552	protein localization to endoplasmic reticulum
KAF59_00640	COG2884	Cell division ATP-binding protein ftsE
KAF59_00645	COG2177	Part of the ABC transporter FtsEX involved in
KAF59_00650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KAF59_00655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KAF59_00670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KAF59_00675	COG4206	TonB-dependent receptor
KAF59_00680	COG1404	Belongs to the peptidase S8 family
KAF59_00685	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KAF59_00755	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KAF59_00760	COG3300	MHYT domain
KAF59_00760	COG5001	Diguanylate cyclase
KAF59_00770	COG3852	Histidine kinase
KAF59_00780	COG0174	glutamine synthetase
KAF59_00790	COG1217	gtp-binding protein TYPA
KAF59_00800	COG1295	ribonuclease BN
KAF59_00805	COG1490	D-aminoacyl-tRNA deacylase activity
KAF59_00810	COG0456	acetyltransferase
KAF59_00820	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
KAF59_00825	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KAF59_00830	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KAF59_00835	COG3031	protein transport across the cell outer membrane
KAF59_00845	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KAF59_00850	COG1459	type II secretion system
KAF59_00855	COG2165	general secretion pathway protein
KAF59_00860	COG2165	general secretion pathway protein
KAF59_00865	COG2165	general secretion pathway protein
KAF59_00870	COG4795	General secretion pathway protein
KAF59_00875	COG3156	type II secretion system protein K
KAF59_00880	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
KAF59_00885	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
KAF59_00895	COG1218	3'(2'),5'-bisphosphate nucleotidase
KAF59_00900	COG0494	nUDIX hydrolase
KAF59_00910	COG1040	competence protein
KAF59_00920	COG0596	Alpha beta hydrolase
KAF59_00930	COG2183	response to ionizing radiation
KAF59_00935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KAF59_00950	COG2233	PERMEase
KAF59_00955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KAF59_00960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KAF59_00965	COG1758	RNA polymerase activity
KAF59_00970	COG0194	GDP metabolic process
KAF59_00975	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KAF59_00980	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KAF59_01000	COG4232	protein-disulfide reductase activity
KAF59_01010	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KAF59_01015	COG1027	Aspartate ammonia-lyase
KAF59_01020	COG3706	GGDEF domain
KAF59_01025	COG3030	protein affecting phage T7 exclusion by the F plasmid
KAF59_01030	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KAF59_01040	COG2205	protein histidine kinase activity
KAF59_01045	COG0745	RESPONSE REGULATOR receiver
KAF59_01055	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KAF59_01060	COG0205	6-phosphofructokinase activity
KAF59_01065	COG1494	fructose-1,6-bisphosphatase
KAF59_01070	COG3074	FtsZ-dependent cytokinesis
KAF59_01075	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KAF59_01080	COG0527	aspartate kinase activity
KAF59_01080	COG0460	homoserine dehydrogenase
KAF59_01085	COG0626	cystathionine gamma-synthase activity
KAF59_01090	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
KAF59_01095	COG0281	malic enzyme
KAF59_01100	COG0254	rRNA binding
KAF59_01105	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KAF59_01110	COG1609	Transcriptional regulator
KAF59_01115	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KAF59_01120	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KAF59_01125	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KAF59_01130	COG1575	Belongs to the MenA family. Type 1 subfamily
KAF59_01135	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KAF59_01140	COG0534	Mate efflux family protein
KAF59_01145	COG0149	triose-phosphate isomerase activity
KAF59_01170	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KAF59_01175	COG0459	protein refolding
KAF59_01185	COG1509	lysine 2,3-aminomutase activity
KAF59_01190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KAF59_01200	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
KAF59_01205	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KAF59_01210	COG1053	succinate dehydrogenase
KAF59_01215	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
KAF59_01220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KAF59_01225	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
KAF59_01230	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KAF59_01235	COG1045	serine acetyltransferase
KAF59_01245	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
KAF59_01250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KAF59_01255	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KAF59_01260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KAF59_01265	COG0137	argininosuccinate synthase activity
KAF59_01270	COG0165	Argininosuccinate lyase
KAF59_01280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KAF59_01285	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KAF59_01285	COG0678	peroxiredoxin activity
KAF59_01295	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KAF59_01325	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KAF59_01330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KAF59_01340	COG0338	D12 class N6 adenine-specific DNA methyltransferase
KAF59_01345	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KAF59_01350	COG0546	phosphoglycolate phosphatase activity
KAF59_01355	COG0180	Tryptophanyl-tRNA synthetase
KAF59_01370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KAF59_01380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KAF59_01390	COG1012	belongs to the aldehyde dehydrogenase family
KAF59_01405	COG3954	Phosphoribulokinase
KAF59_01415	COG0429	hydrolase of the alpha beta-hydrolase fold
KAF59_01425	COG0488	(ABC) transporter
KAF59_01430	COG2249	NAD(P)H dehydrogenase (quinone) activity
KAF59_01445	COG1047	Peptidyl-prolyl cis-trans
KAF59_01460	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
KAF59_01465	COG3083	sulfuric ester hydrolase activity
KAF59_01470	COG0557	exoribonuclease II activity
KAF59_01475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KAF59_01480	COG0051	transcription antitermination factor activity, RNA binding
KAF59_01485	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KAF59_01490	COG0088	Forms part of the polypeptide exit tunnel
KAF59_01495	COG0089	rRNA binding
KAF59_01500	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KAF59_01505	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KAF59_01510	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KAF59_01515	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KAF59_01520	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KAF59_01525	COG0255	Belongs to the universal ribosomal protein uL29 family
KAF59_01530	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KAF59_01535	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KAF59_01540	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KAF59_01545	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KAF59_01550	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KAF59_01555	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KAF59_01565	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KAF59_01570	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KAF59_01575	COG1841	ribosomal large subunit assembly
KAF59_01585	COG0201	protein transport
KAF59_01590	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KAF59_01595	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KAF59_01600	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KAF59_01605	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KAF59_01610	COG0202	RNA polymerase activity
KAF59_01615	COG0203	ribosomal protein L17
KAF59_01625	COG0545	Peptidyl-prolyl cis-trans isomerase
KAF59_01630	COG3061	Opacity-associated protein A
KAF59_01630	COG3266	domain, Protein
KAF59_01635	COG0697	spore germination
KAF59_01640	COG2153	protein acetylation
KAF59_01645	COG0513	Belongs to the DEAD box helicase family
KAF59_01655	COG0737	Belongs to the 5'-nucleotidase family
KAF59_01660	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KAF59_01660	COG1648	precorrin-2 dehydrogenase activity
KAF59_01675	COG0529	Catalyzes the synthesis of activated sulfate
KAF59_01695	COG1136	(ABC) transporter
KAF59_01710	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
KAF59_01715	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KAF59_01720	COG0729	surface antigen
KAF59_01730	COG2105	PFAM AIG2 family protein
KAF59_01735	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KAF59_01745	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KAF59_01750	COG0163	prenyltransferase activity
KAF59_01760	COG1178	ABC-type Fe3 transport system permease component
KAF59_01765	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
KAF59_01770	COG3028	Belongs to the UPF0307 family
KAF59_01775	COG0312	modulator of DNA gyrase
KAF59_01780	COG2239	Acts as a magnesium transporter
KAF59_01785	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KAF59_01790	COG1660	Displays ATPase and GTPase activities
KAF59_01795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KAF59_01800	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KAF59_01810	COG1137	ATPase activity
KAF59_01815	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
KAF59_01830	COG0517	IMP dehydrogenase activity
KAF59_01830	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KAF59_01840	COG1127	ABC transporter
KAF59_01845	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KAF59_01850	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KAF59_01855	COG2854	intermembrane phospholipid transfer
KAF59_01865	COG5007	Belongs to the BolA IbaG family
KAF59_01870	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KAF59_01880	COG0251	oxidation-reduction process
KAF59_01890	COG0540	Belongs to the ATCase OTCase family
KAF59_01900	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KAF59_01910	COG0564	pseudouridine synthase activity
KAF59_01915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KAF59_01920	COG0525	valine-tRNA ligase activity
KAF59_01925	COG2927	DNA polymerase III (CHI subunit)
KAF59_01930	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KAF59_01935	COG0795	lipopolysaccharide-transporting ATPase activity
KAF59_01940	COG0795	lipopolysaccharide-transporting ATPase activity
KAF59_01955	COG3437	response regulator, receiver
KAF59_02000	COG0066	3-isopropylmalate dehydratase activity
KAF59_02005	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KAF59_02010	COG0473	3-isopropylmalate dehydrogenase activity
KAF59_02035	COG0583	DNA-binding transcription factor activity
KAF59_02040	COG1022	Amp-dependent synthetase and ligase
KAF59_02045	COG0028	Belongs to the TPP enzyme family
KAF59_02050	COG0440	acetolactate synthase activity
KAF59_02055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KAF59_02060	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KAF59_02065	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KAF59_02075	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
KAF59_02080	COG3079	Belongs to the UPF0149 family
KAF59_02085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KAF59_02090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KAF59_02105	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
KAF59_02115	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KAF59_02120	COG1595	DNA-templated transcription, initiation
KAF59_02135	COG3086	response to oxidative stress
KAF59_02140	COG0481	GTPase activity
KAF59_02155	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KAF59_02160	COG1381	Involved in DNA repair and RecF pathway recombination
KAF59_02165	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KAF59_02185	COG5001	Diguanylate cyclase
KAF59_02200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KAF59_02205	COG3956	TIGRFAM MazG family protein
KAF59_02210	COG0504	CTP synthase activity
KAF59_02215	COG0148	phosphopyruvate hydratase activity
KAF59_02225	COG3267	Type II secretory pathway component ExeA
KAF59_02225	COG3409	Peptidoglycan-binding domain 1 protein
KAF59_02240	COG0306	phosphate transporter
KAF59_02245	COG1392	Phosphate transport regulator
KAF59_02250	COG3025	triphosphatase activity
KAF59_02255	COG0840	transmembrane signaling receptor activity
KAF59_02260	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KAF59_02270	COG1538	Outer membrane efflux protein
KAF59_02275	COG0494	nUDIX hydrolase
KAF59_02280	COG3151	Protein conserved in bacteria
KAF59_02290	COG3150	esterase
KAF59_02295	COG0187	DNA topoisomerase II activity
KAF59_02300	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KAF59_02310	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
KAF59_02315	COG0237	dephospho-CoA kinase activity
KAF59_02325	COG1459	type II secretion system
KAF59_02330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KAF59_02350	COG0716	FMN binding
KAF59_02355	COG4974	Belongs to the 'phage' integrase family
KAF59_02360	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KAF59_02365	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KAF59_02370	COG0737	Belongs to the 5'-nucleotidase family
KAF59_02375	COG2186	Transcriptional regulator
KAF59_02380	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
KAF59_02385	COG0508	dehydrogenase complex catalyzes the overall conversion of
KAF59_02390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KAF59_02405	COG3116	cell division
KAF59_02410	COG0768	penicillin binding
KAF59_02415	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KAF59_02420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KAF59_02430	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KAF59_02435	COG0772	Belongs to the SEDS family
KAF59_02445	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KAF59_02450	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KAF59_02455	COG0849	cell division
KAF59_02460	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KAF59_02465	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
KAF59_02475	COG0653	protein targeting
KAF59_02480	COG0494	nUDIX hydrolase
KAF59_02485	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KAF59_02495	COG0505	Belongs to the CarA family
KAF59_02500	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KAF59_02515	COG4172	Belongs to the ABC transporter superfamily
KAF59_02525	COG0730	response to heat
KAF59_02530	COG0583	DNA-binding transcription factor activity
KAF59_02535	COG2860	membrane
KAF59_02540	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KAF59_02550	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KAF59_02560	COG0493	'glutamate synthase
KAF59_02565	COG0067	glutamate synthase
KAF59_02565	COG0069	glutamate synthase activity
KAF59_02565	COG0070	glutamate synthase
KAF59_02575	COG0069	glutamate synthase activity
KAF59_02575	COG0070	glutamate synthase
KAF59_02575	COG0067	glutamate synthase
KAF59_02580	COG1242	4 iron, 4 sulfur cluster binding
KAF59_02585	COG2203	Gaf domain
KAF59_02585	COG3706	GGDEF domain
KAF59_02585	COG4251	negative regulation of phosphorylation
KAF59_02585	COG5001	Diguanylate cyclase
KAF59_02590	COG0784	Response regulator, receiver
KAF59_02590	COG2198	Histidine kinase
KAF59_02590	COG5002	protein histidine kinase activity
KAF59_02595	COG0745	RESPONSE REGULATOR receiver
KAF59_02605	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KAF59_02630	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KAF59_02635	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
KAF59_02640	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
KAF59_02645	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KAF59_02660	COG1115	amino acid carrier protein
KAF59_02665	COG3022	response to hydroperoxide
KAF59_02675	COG0084	hydrolase, TatD family'
KAF59_02680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KAF59_02690	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KAF59_02695	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
KAF59_02700	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
KAF59_02705	COG0813	purine-nucleoside phosphorylase activity
KAF59_02715	COG0560	Phosphoserine phosphatase
KAF59_02725	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KAF59_02730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KAF59_02735	COG1022	Amp-dependent synthetase and ligase
KAF59_02750	COG3250	beta-galactosidase activity
KAF59_02755	COG1609	Transcriptional regulator
KAF59_02760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KAF59_02775	COG0189	ligase activity
KAF59_02775	COG0569	domain protein
KAF59_02780	COG0456	acetyltransferase
KAF59_02790	COG2171	N-acyltransferase activity
KAF59_02795	COG3141	response to X-ray
KAF59_02810	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KAF59_02815	COG1074	ATP-dependent DNA helicase activity
KAF59_02820	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KAF59_02830	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
KAF59_02830	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KAF59_02840	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
KAF59_02845	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KAF59_02850	COG2166	iron-sulfur cluster assembly
KAF59_02855	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KAF59_02860	COG0693	protein deglycase activity
KAF59_02865	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KAF59_02870	COG3248	Nucleoside-binding outer membrane protein
KAF59_02880	COG1595	DNA-templated transcription, initiation
KAF59_02890	COG2211	Major facilitator Superfamily
KAF59_02895	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KAF59_02905	COG2813	Specifically methylates the guanine in position
KAF59_02910	COG0271	Belongs to the BolA IbaG family
KAF59_02915	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KAF59_02920	COG1805	sodium ion transport
KAF59_02925	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KAF59_02930	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KAF59_02935	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KAF59_02940	COG2871	sodium ion transport
KAF59_02945	COG1477	protein flavinylation
KAF59_02970	COG0733	neurotransmitter:sodium symporter activity
KAF59_02980	COG0189	ligase activity
KAF59_02985	COG4067	protein conserved in archaea
KAF59_02985	COG0189	ligase activity
KAF59_02990	COG2195	Cleaves the N-terminal amino acid of tripeptides
KAF59_02995	COG2252	PERMEase
KAF59_03000	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
KAF59_03005	COG1073	alpha beta
KAF59_03015	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KAF59_03020	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KAF59_03025	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KAF59_03030	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KAF59_03030	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KAF59_03045	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KAF59_03050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KAF59_03055	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KAF59_03060	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KAF59_03070	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
KAF59_03075	COG0024	Methionine aminopeptidase
KAF59_03080	COG0052	Belongs to the universal ribosomal protein uS2 family
KAF59_03085	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KAF59_03090	COG0528	UMP kinase activity
KAF59_03095	COG0233	cytoplasmic translational termination
KAF59_03100	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KAF59_03105	COG0575	Belongs to the CDS family
KAF59_03110	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KAF59_03115	COG0750	zinc metalloprotease
KAF59_03125	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
KAF59_03130	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KAF59_03135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KAF59_03140	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KAF59_03145	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KAF59_03150	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KAF59_03155	COG0587	DNA-directed DNA polymerase activity
KAF59_03160	COG0825	malonyl-CoA metabolic process
KAF59_03165	COG0037	tRNA processing
KAF59_03175	COG3479	Phenolic acid decarboxylase
KAF59_03180	COG0347	Belongs to the P(II) protein family
KAF59_03185	COG3021	interspecies interaction between organisms
KAF59_03190	COG1388	LysM domain
KAF59_03190	COG0741	lytic transglycosylase activity
KAF59_03195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KAF59_03200	COG2226	methyltransferase
KAF59_03205	COG0328	RNA-DNA hybrid ribonuclease activity
KAF59_03220	COG1960	acyl-CoA dehydrogenase activity
KAF59_03225	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
KAF59_03230	COG0121	glutamine amidotransferase
KAF59_03235	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KAF59_03240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KAF59_03245	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KAF59_03255	COG1187	pseudouridine synthase activity
KAF59_03260	COG2840	Smr protein MutS2
KAF59_03275	COG3735	TraB family
KAF59_03290	COG2217	Heavy metal translocating P-type atpase
KAF59_03290	COG2608	mercury ion transmembrane transporter activity
KAF59_03295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KAF59_03310	COG1629	transport
KAF59_03310	COG4774	siderophore transport
KAF59_03315	COG2375	cellular response to nickel ion
KAF59_03320	COG3433	isochorismatase activity
KAF59_03320	COG2226	methyltransferase
KAF59_03320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KAF59_03355	COG0835	chemotaxis
KAF59_03355	COG0784	Response regulator, receiver
KAF59_03360	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KAF59_03365	COG1815	bacterial-type flagellum-dependent cell motility
KAF59_03380	COG1749	Flagellar hook protein flgE
KAF59_03385	COG4787	bacterial-type flagellum-dependent cell motility
KAF59_03395	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
KAF59_03400	COG1706	bacterial-type flagellum-dependent cell motility
KAF59_03405	COG3951	Flagellar rod assembly protein muramidase FlgJ
KAF59_03405	COG1705	Flagellar rod assembly protein muramidase FlgJ
KAF59_03420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KAF59_03425	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KAF59_03510	COG0012	GTP binding
KAF59_03515	COG0193	aminoacyl-tRNA hydrolase activity
KAF59_03520	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KAF59_03525	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KAF59_03530	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
KAF59_03535	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KAF59_03540	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KAF59_03545	COG2890	protein-(glutamine-N5) methyltransferase activity
KAF59_03555	COG2912	Transglutaminase-like superfamily
KAF59_03560	COG2877	3-deoxy-8-phosphooctulonate synthase activity
KAF59_03565	COG0737	Belongs to the 5'-nucleotidase family
KAF59_03570	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KAF59_03575	COG2233	PERMEase
KAF59_03595	COG1393	Belongs to the ArsC family
KAF59_03600	COG4783	chaperone-mediated protein folding
KAF59_03615	COG0840	transmembrane signaling receptor activity
KAF59_03620	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KAF59_03635	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
KAF59_03645	COG1876	peptidase activity
KAF59_03655	COG1393	Belongs to the ArsC family
KAF59_03675	COG2837	iron assimilation
KAF59_03680	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KAF59_03685	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KAF59_03690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KAF59_03695	COG1334	flagellar protein FlaG
KAF59_03700	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
KAF59_03710	COG1516	flagellar protein fliS
KAF59_03730	COG1677	Flagellar hook-basal body complex protein FliE
KAF59_03740	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KAF59_03745	COG1317	bacterial-type flagellum organization
KAF59_03770	COG1580	Controls the rotational direction of flagella during chemotaxis
KAF59_03795	COG1987	bacterial-type flagellum assembly
KAF59_03800	COG1684	flagellar biosynthetic protein fliR
KAF59_03810	COG2840	Smr protein MutS2
KAF59_03815	COG2890	protein-(glutamine-N5) methyltransferase activity
KAF59_03820	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KAF59_03825	COG2860	membrane
KAF59_03830	COG3101	peptidyl-lysine hydroxylation
KAF59_03840	COG0431	NADPH-dependent FMN reductase
KAF59_03850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KAF59_03855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KAF59_03860	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KAF59_03865	COG0735	belongs to the Fur family
KAF59_03875	COG0583	DNA-binding transcription factor activity
KAF59_03885	COG1346	cytolysis
KAF59_03900	COG0596	Alpha beta hydrolase
KAF59_03905	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
KAF59_03910	COG0033	Phosphoglucomutase
KAF59_03920	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KAF59_03925	COG0372	Belongs to the citrate synthase family
KAF59_03930	COG2009	succinate dehydrogenase
KAF59_03935	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
KAF59_03940	COG1053	succinate dehydrogenase
KAF59_03950	COG0567	Dehydrogenase, E1 component
KAF59_03955	COG0508	dehydrogenase complex catalyzes the overall conversion of
KAF59_03960	COG0045	succinate-CoA ligase (ADP-forming) activity
KAF59_03970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KAF59_03975	COG1121	(ABC) transporter
KAF59_03980	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
KAF59_03985	COG4977	sequence-specific DNA binding
KAF59_03990	COG1918	ferrous iron import across plasma membrane
KAF59_04010	COG0018	arginyl-trna synthetase
KAF59_04020	COG1025	Belongs to the peptidase M16 family
KAF59_04025	COG2062	phosphohistidine phosphatase, SixA
KAF59_04055	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
KAF59_04060	COG0643	Histidine kinase
KAF59_04060	COG0784	Response regulator, receiver
KAF59_04060	COG2198	Histidine kinase
KAF59_04065	COG2201	protein-glutamate methylesterase activity
KAF59_04070	COG1192	Involved in chromosome partitioning
KAF59_04080	COG0835	chemotaxis
KAF59_04090	COG4133	protoheme IX ABC transporter activity
KAF59_04095	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KAF59_04100	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KAF59_04110	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
KAF59_04115	COG1138	Cytochrome C-type biogenesis protein
KAF59_04120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KAF59_04125	COG4235	cytochrome complex assembly
KAF59_04125	COG3088	subunit of a heme lyase
KAF59_04135	COG2853	Lipoprotein
KAF59_04155	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KAF59_04160	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KAF59_04165	COG0123	including yeast histone deacetylase and acetoin utilization protein
KAF59_04180	COG3083	sulfuric ester hydrolase activity
KAF59_04185	COG3082	Protein of unknown function (DUF1414)
KAF59_04190	COG3081	Nucleoid-associated protein
KAF59_04200	COG1757	Na H antiporter
KAF59_04205	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KAF59_04210	COG2095	MarC family integral membrane protein
KAF59_04215	COG1454	alcohol dehydrogenase
KAF59_04215	COG1012	belongs to the aldehyde dehydrogenase family
KAF59_04225	COG0659	secondary active sulfate transmembrane transporter activity
KAF59_04230	COG1530	ribonuclease E activity
KAF59_04235	COG0564	pseudouridine synthase activity
KAF59_04240	COG0424	maF-like protein
KAF59_04245	COG1399	metal-binding, possibly nucleic acid-binding protein
KAF59_04250	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KAF59_04255	COG0416	fatty acid biosynthetic process
KAF59_04260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KAF59_04270	COG1028	Short-chain dehydrogenase reductase Sdr
KAF59_04275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KAF59_04280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KAF59_04285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KAF59_04290	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KAF59_04295	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KAF59_04305	COG0084	hydrolase, TatD family'
KAF59_04310	COG1263	PTS System
KAF59_04310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KAF59_04320	COG0733	neurotransmitter:sodium symporter activity
KAF59_04335	COG4667	esterase of the alpha-beta hydrolase superfamily
KAF59_04345	COG1940	carbohydrate kinase activity
KAF59_04350	COG0784	Response regulator, receiver
KAF59_04350	COG0835	chemotaxis
KAF59_04365	COG2226	methyltransferase
KAF59_04375	COG0676	glucose-6-phosphate 1-epimerase activity
KAF59_04380	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KAF59_04385	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KAF59_04395	COG3139	Protein of unknown function (DUF1315)
KAF59_04400	COG0252	asparaginase activity
KAF59_04405	COG0616	signal peptide processing
KAF59_04410	COG0446	pyridine nucleotide-disulphide oxidoreductase
KAF59_04410	COG1902	pentaerythritol trinitrate reductase activity
KAF59_04415	COG0788	formyltetrahydrofolate deformylase activity
KAF59_04425	COG1199	ATP-dependent helicase activity
KAF59_04430	COG1214	PFAM Peptidase M22, glycoprotease
KAF59_04445	COG0596	Alpha beta hydrolase
KAF59_04450	COG0318	PFAM AMP-dependent synthetase and ligase
KAF59_04455	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
KAF59_04475	COG0232	Belongs to the dGTPase family. Type 2 subfamily
KAF59_04480	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
KAF59_04485	COG0436	Aminotransferase
KAF59_04490	COG1169	isochorismate synthase
KAF59_04495	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KAF59_04500	COG0596	Alpha beta hydrolase
KAF59_04520	COG3135	benzoate transporter
KAF59_04525	COG1396	sequence-specific DNA binding
KAF59_04530	COG0840	transmembrane signaling receptor activity
KAF59_04545	COG0477	Major facilitator Superfamily
KAF59_04565	COG3015	lipoprotein NlpE involved in copper resistance
KAF59_04570	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
KAF59_04575	COG2894	cell division
KAF59_04580	COG0850	regulation of cytokinetic process
KAF59_04585	COG3100	YcgL domain-containing protein
KAF59_04590	COG2951	lytic endotransglycosylase activity
KAF59_04600	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KAF59_04605	COG3325	Belongs to the glycosyl hydrolase 18 family
KAF59_04605	COG3469	chitinase activity
KAF59_04610	COG3005	denitrification pathway
KAF59_04615	COG0243	molybdopterin cofactor binding
KAF59_04630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KAF59_04640	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KAF59_04675	COG4589	Belongs to the CDS family
KAF59_04685	COG3300	MHYT domain
KAF59_04685	COG5001	Diguanylate cyclase
KAF59_04695	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
KAF59_04700	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KAF59_04705	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KAF59_04710	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KAF59_04720	COG4191	Histidine kinase
KAF59_04730	COG0544	peptidyl-prolyl cis-trans isomerase activity
KAF59_04740	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KAF59_04745	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KAF59_04750	COG0776	regulation of translation
KAF59_04755	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KAF59_04760	COG1555	photosystem II stabilization
KAF59_04765	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KAF59_04770	COG0539	negative regulation of cytoplasmic translation
KAF59_04775	COG0776	regulation of translation
KAF59_04780	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
KAF59_04785	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
KAF59_04805	COG0583	DNA-binding transcription factor activity
KAF59_04815	COG0686	Belongs to the AlaDH PNT family
KAF59_04825	COG1674	ftsk spoiiie
KAF59_04830	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KAF59_04835	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KAF59_04840	COG2186	Transcriptional regulator
KAF59_04855	COG0537	adenosine 5'-monophosphoramidase activity
KAF59_04880	COG3150	esterase
KAF59_04885	COG1252	NADH dehydrogenase
KAF59_04905	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KAF59_04915	COG4591	ABC-type transport system involved in lipoprotein release permease component
KAF59_04920	COG1136	(ABC) transporter
KAF59_04925	COG4591	ABC-type transport system involved in lipoprotein release permease component
KAF59_04935	COG2333	competence protein COMEC
KAF59_04935	COG0658	competence protein
KAF59_04940	COG1132	(ABC) transporter
KAF59_04945	COG1663	tetraacyldisaccharide 4'-kinase activity
KAF59_04950	COG2835	tetraacyldisaccharide 4'-kinase activity
KAF59_04955	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KAF59_04960	COG2719	SpoVR family
KAF59_04965	COG2718	Belongs to the UPF0229 family
KAF59_04970	COG2766	serine protein kinase
KAF59_04975	COG3013	Belongs to the UPF0304 family
KAF59_04985	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KAF59_04990	COG0840	transmembrane signaling receptor activity
KAF59_05000	COG1882	Formate acetyltransferase
KAF59_05025	COG4160	amino acid transport
KAF59_05030	COG0708	Exodeoxyribonuclease III
KAF59_05035	COG0840	transmembrane signaling receptor activity
KAF59_05045	COG3923	Primosomal replication protein n
KAF59_05050	COG0730	response to heat
KAF59_05055	COG1199	ATP-dependent helicase activity
KAF59_05060	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
KAF59_05065	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
KAF59_05070	COG3012	SEC-C Motif Domain Protein
KAF59_05075	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
KAF59_05080	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KAF59_05085	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KAF59_05090	COG0215	cysteine-tRNA ligase activity
KAF59_05095	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KAF59_05100	COG0632	four-way junction helicase activity
KAF59_05110	COG1271	oxidase subunit
KAF59_05115	COG1294	oxidase, subunit
KAF59_05120	COG4890	Cyd operon protein YbgT
KAF59_05125	COG3790	cyd operon protein YbgE
KAF59_05130	COG0824	Thioesterase
KAF59_05135	COG0811	peptide transport
KAF59_05150	COG0823	Involved in the tonB-independent uptake of proteins
KAF59_05155	COG2885	chlorophyll binding
KAF59_05165	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KAF59_05175	COG0784	Response regulator, receiver
KAF59_05175	COG5002	protein histidine kinase activity
KAF59_05185	COG1482	cell wall glycoprotein biosynthetic process
KAF59_05190	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KAF59_05190	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KAF59_05190	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KAF59_05195	COG2207	Transcriptional regulator
KAF59_05205	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KAF59_05210	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KAF59_05215	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KAF59_05225	COG1012	belongs to the aldehyde dehydrogenase family
KAF59_05230	COG3284	Transcriptional regulator
KAF59_05235	COG4628	conserved protein (DUF2132)
KAF59_05245	COG0415	Belongs to the DNA photolyase family
KAF59_05325	COG0488	(ABC) transporter
KAF59_05365	COG3941	tape measure
KAF59_05380	COG0582	viral genome integration into host DNA
KAF59_05385	COG0582	viral genome integration into host DNA
KAF59_05400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KAF59_05410	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KAF59_05410	COG3008	intermembrane lipid transfer
KAF59_05420	COG0668	transmembrane transport
KAF59_05440	COG1309	transcriptional regulator
KAF59_05445	COG1012	belongs to the aldehyde dehydrogenase family
KAF59_05475	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KAF59_05480	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KAF59_05505	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KAF59_05510	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KAF59_05515	COG0297	glycogen (starch) synthase activity
KAF59_05535	COG3070	regulator of competence-specific genes
KAF59_05540	COG1609	Transcriptional regulator
KAF59_05545	COG3381	protein complex oligomerization
KAF59_05550	COG0745	RESPONSE REGULATOR receiver
KAF59_05555	COG1434	Gram-negative-bacterium-type cell wall biogenesis
KAF59_05560	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KAF59_05570	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
KAF59_05590	COG1032	radical SAM domain protein
KAF59_05595	COG5001	Diguanylate cyclase
KAF59_05600	COG0612	Peptidase, M16
KAF59_05615	COG0583	DNA-binding transcription factor activity
KAF59_05620	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KAF59_05630	COG2350	Protein conserved in bacteria
KAF59_05635	COG1607	acyl-coa hydrolase
KAF59_05650	COG1434	Gram-negative-bacterium-type cell wall biogenesis
KAF59_05655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KAF59_05665	COG2116	formate transmembrane transporter activity
KAF59_05675	COG4459	periplasmic nitrate reductase
KAF59_05680	COG3005	denitrification pathway
KAF59_05685	COG0243	molybdopterin cofactor binding
KAF59_05705	COG1227	inorganic diphosphatase activity
KAF59_05720	COG4172	Belongs to the ABC transporter superfamily
KAF59_05735	COG4168	peptide transport system, permease
KAF59_05745	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
KAF59_05750	COG1842	Phage shock protein A
KAF59_05765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KAF59_05780	COG2818	Glycosylase
KAF59_05785	COG0626	cystathionine gamma-synthase activity
KAF59_05795	COG0733	neurotransmitter:sodium symporter activity
KAF59_05800	COG0564	pseudouridine synthase activity
KAF59_05805	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KAF59_05810	COG4136	ATPase activity
KAF59_05815	COG4135	transport system, permease component
KAF59_05820	COG4134	Bacterial extracellular solute-binding protein
KAF59_05830	COG3313	Fe-S protein
KAF59_05840	COG0842	Transport permease protein
KAF59_05845	COG1131	(ABC) transporter
KAF59_05850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KAF59_05855	COG0814	amino acid
KAF59_05865	COG2239	Acts as a magnesium transporter
KAF59_05870	COG2205	protein histidine kinase activity
KAF59_05870	COG0784	Response regulator, receiver
KAF59_05885	COG4934	collagen metabolic process
KAF59_05915	COG0840	transmembrane signaling receptor activity
KAF59_05925	COG2203	Gaf domain
KAF59_05925	COG3706	GGDEF domain
KAF59_05925	COG4251	negative regulation of phosphorylation
KAF59_05925	COG5001	Diguanylate cyclase
KAF59_05930	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KAF59_05950	COG1061	Type III restriction enzyme res subunit
KAF59_05955	COG1187	pseudouridine synthase activity
KAF59_05960	COG2814	Major facilitator Superfamily
KAF59_05970	COG0702	epimerase
KAF59_05975	COG0534	Mate efflux family protein
KAF59_05980	COG4181	ATPase activity
KAF59_05985	COG0577	efflux transmembrane transporter activity
KAF59_05995	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KAF59_06005	COG1748	Saccharopine dehydrogenase
KAF59_06020	COG1538	Outer membrane efflux protein
KAF59_06040	COG0583	DNA-binding transcription factor activity
KAF59_06050	COG1451	nucleotide metabolic process
KAF59_06055	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
KAF59_06065	COG3063	Type IV pilus biogenesis stability protein PilW
KAF59_06070	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
KAF59_06090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KAF59_06105	COG3290	protein histidine kinase activity
KAF59_06110	COG4565	transcriptional regulatory protein
KAF59_06120	COG0835	chemotaxis
KAF59_06120	COG0784	Response regulator, receiver
KAF59_06165	COG1085	galactose-1-phosphate uridylyltransferase
KAF59_06170	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KAF59_06175	COG2017	converts alpha-aldose to the beta-anomer
KAF59_06185	COG2200	EAL domain
KAF59_06185	COG2199	diguanylate cyclase activity
KAF59_06200	COG3527	Alpha-acetolactate decarboxylase
KAF59_06215	COG0753	catalase activity
KAF59_06235	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KAF59_06245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KAF59_06285	COG1271	oxidase subunit
KAF59_06290	COG1294	oxidase, subunit
KAF59_06295	COG1136	(ABC) transporter
KAF59_06295	COG4591	ABC-type transport system involved in lipoprotein release permease component
KAF59_06300	COG0577	efflux transmembrane transporter activity
KAF59_06300	COG1136	(ABC) transporter
KAF59_06305	COG0577	efflux transmembrane transporter activity
KAF59_06305	COG1136	(ABC) transporter
KAF59_06325	COG0583	DNA-binding transcription factor activity
KAF59_06335	COG2723	6-phospho-beta-galactosidase activity
KAF59_06340	COG1609	Transcriptional regulator
KAF59_06345	COG0251	oxidation-reduction process
KAF59_06350	COG2731	YhcH YjgK YiaL family protein
KAF59_06355	COG0584	glycerophosphoryl diester phosphodiesterase
KAF59_06360	COG1349	DNA-binding transcription factor activity
KAF59_06365	COG3842	ATPase activity
KAF59_06370	COG0395	ABC-type sugar transport system, permease component
KAF59_06375	COG1175	transmembrane transport
KAF59_06390	COG0811	peptide transport
KAF59_06395	COG0811	peptide transport
KAF59_06400	COG0848	biopolymer transport protein
KAF59_06405	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
KAF59_06415	COG1793	dna ligase
KAF59_06425	COG0534	Mate efflux family protein
KAF59_06435	COG3001	Fructosamine kinase
KAF59_06445	COG0791	NLP P60 protein
KAF59_06450	COG0840	transmembrane signaling receptor activity
KAF59_06460	COG3148	PFAM DTW domain containing protein
KAF59_06465	COG1940	carbohydrate kinase activity
KAF59_06490	COG0746	molybdenum cofactor guanylyltransferase activity
KAF59_06495	COG3842	ATPase activity
KAF59_06500	COG4662	Binding-protein-dependent transport system inner membrane component
KAF59_06510	COG2204	response regulator
KAF59_06515	COG3852	Histidine kinase
KAF59_06520	COG0488	(ABC) transporter
KAF59_06525	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KAF59_06555	COG0243	molybdopterin cofactor binding
KAF59_06555	COG3383	formate dehydrogenase (NAD+) activity
KAF59_06560	COG0437	4 iron, 4 sulfur cluster binding
KAF59_06575	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KAF59_06580	COG1666	GTP binding
KAF59_06585	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KAF59_06600	COG2996	Protein conserved in bacteria
KAF59_06610	COG3008	intermembrane lipid transfer
KAF59_06615	COG2995	paraquat-inducible protein a
KAF59_06620	COG1132	(ABC) transporter
KAF59_06625	COG1956	GAF domain-containing protein
KAF59_06630	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
KAF59_06645	COG0308	aminopeptidase N
KAF59_06660	COG0167	dihydroorotate dehydrogenase activity
KAF59_06670	COG0116	Belongs to the methyltransferase superfamily
KAF59_06670	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KAF59_06680	COG0488	(ABC) transporter
KAF59_06695	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KAF59_06700	COG1067	ATP-dependent peptidase activity
KAF59_06705	COG3120	sequence-specific DNA binding
KAF59_06780	COG1476	TRANSCRIPTIONal
KAF59_06810	COG4128	Pfam Zonular occludens toxin
KAF59_06855	COG4128	Pfam Zonular occludens toxin
KAF59_06875	COG4128	Pfam Zonular occludens toxin
KAF59_06925	COG1073	alpha beta
KAF59_06925	COG3064	Membrane
KAF59_06925	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
KAF59_06930	COG2994	toxin metabolic process
KAF59_06955	COG0784	Response regulator, receiver
KAF59_06955	COG2205	protein histidine kinase activity
KAF59_06970	COG3278	Belongs to the heme-copper respiratory oxidase family
KAF59_06985	COG2010	Cytochrome c
KAF59_06995	COG2217	Heavy metal translocating P-type atpase
KAF59_07010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KAF59_07015	COG0589	response to stress
KAF59_07040	COG3842	ATPase activity
KAF59_07050	COG1177	transmembrane transport
KAF59_07060	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KAF59_07075	COG1115	amino acid carrier protein
KAF59_07080	COG1280	lysine exporter protein (LysE YggA)
KAF59_07095	COG3675	Pfam Lipase (class 3)
KAF59_07105	COG3501	Rhs element vgr protein
KAF59_07115	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KAF59_07125	COG2814	Major facilitator Superfamily
KAF59_07130	COG1566	PFAM secretion protein HlyD family protein
KAF59_07135	COG1538	Outer membrane efflux protein
KAF59_07145	COG0513	Belongs to the DEAD box helicase family
KAF59_07155	COG0840	transmembrane signaling receptor activity
KAF59_07160	COG0840	transmembrane signaling receptor activity
KAF59_07160	COG3290	protein histidine kinase activity
KAF59_07165	COG0835	chemotaxis
KAF59_07170	COG2201	protein-glutamate methylesterase activity
KAF59_07180	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KAF59_07185	COG0643	Histidine kinase
KAF59_07185	COG0784	Response regulator, receiver
KAF59_07185	COG2198	Histidine kinase
KAF59_07190	COG2198	Histidine kinase
KAF59_07190	COG0643	Histidine kinase
KAF59_07200	COG0745	RESPONSE REGULATOR receiver
KAF59_07215	COG0415	Belongs to the DNA photolyase family
KAF59_07220	COG0477	Major facilitator Superfamily
KAF59_07225	COG0583	DNA-binding transcription factor activity
KAF59_07235	COG0095	Lipoate-protein ligase
KAF59_07240	COG0443	Heat shock 70 kDa protein
KAF59_07250	COG1643	Atp-dependent helicase
KAF59_07280	COG0443	Heat shock 70 kDa protein
KAF59_07285	COG0443	Heat shock 70 kDa protein
KAF59_07290	COG3706	GGDEF domain
KAF59_07320	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KAF59_07325	COG0602	queuosine metabolic process
KAF59_07330	COG0561	phosphatase activity
KAF59_07340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KAF59_07345	COG4597	amino acid ABC transporter
KAF59_07350	COG0765	amino acid transport
KAF59_07355	COG1126	abc transporter atp-binding protein
KAF59_07360	COG0670	Belongs to the BI1 family
KAF59_07365	COG2920	part of a sulfur-relay system
KAF59_07370	COG1254	Belongs to the acylphosphatase family
KAF59_07375	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KAF59_07380	COG3706	GGDEF domain
KAF59_07395	COG3437	response regulator, receiver
KAF59_07400	COG0625	glutathione transferase activity
KAF59_07410	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
KAF59_07420	COG2195	Cleaves the N-terminal amino acid of tripeptides
KAF59_07450	COG0372	Belongs to the citrate synthase family
KAF59_07455	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KAF59_07495	COG1129	ABC transporter
KAF59_07520	COG0745	RESPONSE REGULATOR receiver
KAF59_07525	COG2205	protein histidine kinase activity
KAF59_07530	COG3713	MltA-interacting MipA family protein
KAF59_07535	COG2990	Protein conserved in bacteria
KAF59_07545	COG4191	Histidine kinase
KAF59_07545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KAF59_07550	COG0471	metal ion transport
KAF59_07560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KAF59_07575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KAF59_07585	COG3768	UPF0283 membrane protein
KAF59_07590	COG3106	COG3106 Predicted ATPase
KAF59_07605	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KAF59_07610	COG0494	nUDIX hydrolase
KAF59_07615	COG0814	amino acid
KAF59_07620	COG1760	l-serine dehydratase
KAF59_07625	COG0720	synthase
KAF59_07635	COG0017	Asparaginyl-tRNA synthetase
KAF59_07640	COG0351	phosphomethylpyrimidine kinase
KAF59_07645	COG3437	response regulator, receiver
KAF59_07645	COG2770	Histidine kinase
KAF59_07650	COG1448	Aminotransferase
KAF59_07665	COG0840	transmembrane signaling receptor activity
KAF59_07670	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
KAF59_07675	COG2943	transferase activity, transferring hexosyl groups
KAF59_07680	COG1609	Transcriptional regulator
KAF59_07690	COG1486	melibiose metabolic process
KAF59_07695	COG1447	Phosphotransferase system cellobiose-specific component IIA
KAF59_07705	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KAF59_07710	COG0726	polysaccharide deacetylase
KAF59_07715	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KAF59_07720	COG1846	Transcriptional regulator
KAF59_07745	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
KAF59_07760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KAF59_07765	COG3108	Peptidase M15
KAF59_07770	COG2989	Protein conserved in bacteria
KAF59_07795	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KAF59_07805	COG2814	Major facilitator Superfamily
KAF59_07815	COG1054	Belongs to the UPF0176 family
KAF59_07825	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KAF59_07830	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KAF59_07835	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KAF59_07885	COG4139	cobalamin transport
KAF59_07905	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
KAF59_07910	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
KAF59_07915	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KAF59_07920	COG1823	symporter activity
KAF59_07925	COG2925	Exonuclease
KAF59_07930	COG1380	Effector of murein hydrolase LrgA
KAF59_07935	COG1346	cytolysis
KAF59_07965	COG0776	regulation of translation
KAF59_07970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KAF59_07970	COG0072	phenylalanine-tRNA ligase activity
KAF59_07975	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KAF59_08015	COG0322	excinuclease ABC activity
KAF59_08020	COG2197	response regulator
KAF59_08025	COG0417	DNA replication proofreading
KAF59_08030	COG5001	Diguanylate cyclase
KAF59_08040	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KAF59_08045	COG3099	Belongs to the UPF0263 family
KAF59_08060	COG1228	amidohydrolase
KAF59_08065	COG0010	Belongs to the arginase family
KAF59_08070	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
KAF59_08075	COG2986	histidine ammonia-lyase
KAF59_08095	COG0277	FAD linked oxidase domain protein
KAF59_08095	COG0247	lactate metabolic process
KAF59_08110	COG2885	chlorophyll binding
KAF59_08130	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KAF59_08140	COG0281	malic enzyme
KAF59_08150	COG2949	membrane
KAF59_08155	COG3706	GGDEF domain
KAF59_08160	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KAF59_08170	COG0492	ferredoxin-NADP+ reductase activity
KAF59_08175	COG4988	ABC transporter
KAF59_08180	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KAF59_08185	COG1187	pseudouridine synthase activity
KAF59_08190	COG0009	L-threonylcarbamoyladenylate synthase
KAF59_08195	COG0613	PHP domain protein
KAF59_08205	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KAF59_08210	COG0512	Glutamine amidotransferase of anthranilate synthase
KAF59_08215	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KAF59_08220	COG0135	phosphoribosylanthranilate isomerase activity
KAF59_08220	COG0134	indole-3-glycerol-phosphate synthase activity
KAF59_08225	COG0133	tryptophan synthase activity
KAF59_08230	COG0159	tryptophan synthase activity
KAF59_08240	COG1435	thymidine kinase activity
KAF59_08245	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KAF59_08250	COG1801	Protein of unknown function DUF72
KAF59_08255	COG4106	trans-aconitate 2-methyltransferase activity
KAF59_08260	COG0500	methyltransferase
KAF59_08265	COG0189	ligase activity
KAF59_08265	COG4067	protein conserved in archaea
KAF59_08280	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KAF59_08290	COG3852	Histidine kinase
KAF59_08305	COG3070	regulator of competence-specific genes
KAF59_08315	COG2431	L-lysine efflux transmembrane transporter activity
KAF59_08325	COG0076	glutamate decarboxylase activity
KAF59_08330	COG1737	Transcriptional regulator
KAF59_08335	COG1012	belongs to the aldehyde dehydrogenase family
KAF59_08335	COG1454	alcohol dehydrogenase
KAF59_08340	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KAF59_08345	COG2985	domain, Protein
KAF59_08345	COG3273	potassium ion transport
KAF59_08350	COG0542	response to heat
KAF59_08355	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KAF59_08360	COG1278	Cold shock
KAF59_08370	COG1187	pseudouridine synthase activity
KAF59_08375	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KAF59_08375	COG0140	phosphoribosyl-ATP diphosphatase activity
KAF59_08380	COG0107	imidazoleglycerol-phosphate synthase activity
KAF59_08385	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KAF59_08390	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KAF59_08395	COG0131	Imidazoleglycerol-phosphate dehydratase
KAF59_08395	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
KAF59_08400	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KAF59_08405	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KAF59_08410	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KAF59_08415	COG1757	Na H antiporter
KAF59_08420	COG2916	Histone family protein nucleoid-structuring protein H-NS
KAF59_08425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KAF59_08430	COG0482	sulfurtransferase activity
KAF59_08435	COG2915	High frequency lysogenization protein hflD homolog
KAF59_08440	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KAF59_08450	COG2268	Band 7 protein
KAF59_08460	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KAF59_08475	COG0300	oxidoreductase activity
KAF59_08485	COG0501	Belongs to the peptidase M48B family
KAF59_08495	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KAF59_08500	COG2226	methyltransferase
KAF59_08505	COG0156	8-amino-7-oxononanoate synthase activity
KAF59_08510	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KAF59_08515	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KAF59_08520	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KAF59_08525	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KAF59_08530	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KAF59_08540	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KAF59_08545	COG2199	diguanylate cyclase activity
KAF59_08545	COG2203	Gaf domain
KAF59_08555	COG4120	Belongs to the binding-protein-dependent transport system permease family
KAF59_08565	COG4628	conserved protein (DUF2132)
KAF59_08570	COG3092	negative regulation of chromosome organization
KAF59_08575	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KAF59_08580	COG0280	phosphate acetyltransferase
KAF59_08580	COG0857	belongs to the CobB CobQ family
KAF59_08585	COG0435	Glutathione S-transferase
KAF59_08590	COG4608	Belongs to the ABC transporter superfamily
KAF59_08595	COG0444	Belongs to the ABC transporter superfamily
KAF59_08600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KAF59_08605	COG0601	transmembrane transport
KAF59_08625	COG2204	response regulator
KAF59_08630	COG3300	MHYT domain
KAF59_08630	COG5001	Diguanylate cyclase
KAF59_08635	COG4191	Histidine kinase
KAF59_08640	COG5002	protein histidine kinase activity
KAF59_08650	COG2201	protein-glutamate methylesterase activity
KAF59_08665	COG0009	L-threonylcarbamoyladenylate synthase
KAF59_08680	COG1881	PFAM PEBP family protein
KAF59_08705	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KAF59_08710	COG0640	Transcriptional regulator
KAF59_08720	COG3706	GGDEF domain
KAF59_08740	COG1946	Acyl-CoA thioesterase
KAF59_08745	COG1522	sequence-specific DNA binding
KAF59_08755	COG0616	signal peptide processing
KAF59_08760	COG1028	Short-chain dehydrogenase reductase Sdr
KAF59_08765	COG2983	Belongs to the UPF0260 family
KAF59_08775	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KAF59_08780	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KAF59_08790	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KAF59_08795	COG2832	Protein of unknown function (DUF454)
KAF59_08800	COG0745	RESPONSE REGULATOR receiver
KAF59_08805	COG0583	DNA-binding transcription factor activity
KAF59_08810	COG0778	Nitroreductase
KAF59_08815	COG1250	3-hydroxyacyl-CoA dehydrogenase
KAF59_08815	COG1024	Enoyl-CoA hydratase
KAF59_08820	COG0183	Belongs to the thiolase family
KAF59_08835	COG2067	long-chain fatty acid transport protein
KAF59_08845	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KAF59_08850	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
KAF59_08855	COG2982	Protein involved in outer membrane biogenesis
KAF59_08860	COG0572	uridine kinase
KAF59_08865	COG0489	protein tyrosine kinase activity
KAF59_08870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KAF59_08870	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KAF59_08880	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
KAF59_08890	COG0517	IMP dehydrogenase activity
KAF59_08890	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KAF59_08890	COG0617	tRNA 3'-terminal CCA addition
KAF59_08895	COG2199	diguanylate cyclase activity
KAF59_08900	COG0314	molybdopterin synthase activity
KAF59_08905	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KAF59_08910	COG0315	cyclic pyranopterin monophosphate synthase activity
KAF59_08915	COG0521	Mo-molybdopterin cofactor biosynthetic process
KAF59_08920	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KAF59_08925	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KAF59_08930	COG2198	Histidine kinase
KAF59_08935	COG2204	response regulator
KAF59_08940	COG0556	nucleotide-excision repair
KAF59_08950	COG4657	Part of a membrane complex involved in electron transport
KAF59_08955	COG2878	Part of a membrane complex involved in electron transport
KAF59_08960	COG4656	Part of a membrane complex involved in electron transport
KAF59_08980	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KAF59_08985	COG0346	lactoylglutathione lyase activity
KAF59_09000	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KAF59_09005	COG2056	Na+-H+ antiporter family
KAF59_09010	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KAF59_09015	COG1286	toxin biosynthetic process
KAF59_09020	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
KAF59_09025	COG0285	dihydrofolate synthase activity
KAF59_09030	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KAF59_09035	COG0101	tRNA pseudouridine synthase activity
KAF59_09050	COG1263	PTS System
KAF59_09050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KAF59_09050	COG2190	(PTS) system
KAF59_09055	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KAF59_09060	COG1940	carbohydrate kinase activity
KAF59_09060	COG1846	Transcriptional regulator
KAF59_09065	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KAF59_09065	COG4651	solute:proton antiporter activity
KAF59_09070	COG0367	asparagine synthase
KAF59_09085	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KAF59_09090	COG0563	adenylate kinase activity
KAF59_09095	COG0326	Molecular chaperone. Has ATPase activity
KAF59_09115	COG0622	Phosphoesterase
KAF59_09120	COG1090	epimerase
KAF59_09125	COG0300	oxidoreductase activity
KAF59_09130	COG3118	belongs to the thioredoxin family
KAF59_09135	COG0330	HflC and HflK could
KAF59_09140	COG1585	Membrane protein implicated in regulation of membrane protease activity
KAF59_09145	COG0789	Transcriptional regulator
KAF59_09160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KAF59_09165	COG3115	cell septum assembly
KAF59_09170	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
KAF59_09175	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KAF59_09180	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KAF59_09190	COG2190	(PTS) system
KAF59_09195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KAF59_09200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KAF59_09205	COG1702	phosphate starvation-inducible protein PhoH
KAF59_09215	COG4535	Mg2 and Co2 transporter CorC
KAF59_09220	COG0815	Transfers the fatty acyl group on membrane lipoproteins
KAF59_09225	COG2888	peptidyl-tyrosine sulfation
KAF59_09230	COG0495	leucyl-tRNA aminoacylation
KAF59_09235	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
KAF59_09240	COG1466	dna polymerase III delta subunit
KAF59_09245	COG0799	negative regulation of ribosome biogenesis
KAF59_09250	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KAF59_09255	COG0768	penicillin binding
KAF59_09260	COG0772	Belongs to the SEDS family
KAF59_09265	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KAF59_09270	COG1686	Belongs to the peptidase S11 family
KAF59_09275	COG2921	Belongs to the UPF0250 family
KAF59_09280	COG0321	lipoyl(octanoyl) transferase activity
KAF59_09285	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KAF59_09295	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KAF59_09320	COG1596	polysaccharide export
KAF59_09330	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KAF59_09360	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
KAF59_09370	COG0438	transferase activity, transferring glycosyl groups
KAF59_09380	COG1045	serine acetyltransferase
KAF59_09400	COG0110	maltose O-acetyltransferase activity
KAF59_09405	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KAF59_09410	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KAF59_09415	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KAF59_09420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KAF59_09450	COG0366	Alpha amylase catalytic
KAF59_09455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KAF59_09455	COG1263	PTS System
KAF59_09460	COG1609	Transcriptional regulator
KAF59_09465	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
KAF59_09470	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KAF59_09475	COG2011	ABC-type metal ion transport system permease component
KAF59_09480	COG1464	Belongs to the NlpA lipoprotein family
KAF59_09485	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
KAF59_09495	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KAF59_09495	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KAF59_09510	COG1611	Belongs to the LOG family
KAF59_09515	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KAF59_09520	COG2363	Small membrane protein
KAF59_09525	COG0583	DNA-binding transcription factor activity
KAF59_09530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KAF59_09530	COG0301	tRNA thio-modification
KAF59_09540	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KAF59_09545	COG1722	exodeoxyribonuclease VII activity
KAF59_09550	COG0142	geranyltranstransferase activity
KAF59_09555	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KAF59_09560	COG0564	pseudouridine synthase activity
KAF59_09565	COG3098	single-species biofilm formation
KAF59_09580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KAF59_09590	COG1671	Belongs to the UPF0178 family
KAF59_09595	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
KAF59_09600	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KAF59_09605	COG0254	rRNA binding
KAF59_09610	COG1720	tRNA m6t6A37 methyltransferase activity
KAF59_09615	COG0442	prolyl-tRNA aminoacylation
KAF59_09640	COG0047	phosphoribosylformylglycinamidine synthase activity
KAF59_09640	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KAF59_09650	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
KAF59_09660	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
KAF59_09690	COG0484	heat shock protein binding
KAF59_09695	COG0443	Heat shock 70 kDa protein
KAF59_09705	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KAF59_09710	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KAF59_09715	COG0497	DNA recombination
KAF59_09720	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KAF59_09725	COG2914	Belongs to the UPF0125 (RnfH) family
KAF59_09730	COG2867	negative regulation of translational initiation
KAF59_09735	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KAF59_09745	COG0582	viral genome integration into host DNA
KAF59_09755	COG0582	viral genome integration into host DNA
KAF59_09760	COG3064	Membrane
KAF59_09770	COG0739	heme binding
KAF59_09785	COG0840	transmembrane signaling receptor activity
KAF59_09790	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KAF59_09795	COG2207	Transcriptional regulator
KAF59_09805	COG1459	type II secretion system
KAF59_09810	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KAF59_09830	COG4796	Type ii and iii secretion system protein
KAF59_09845	COG2165	general secretion pathway protein
KAF59_09855	COG3710	Transcriptional regulator
KAF59_09860	COG0840	transmembrane signaling receptor activity
KAF59_09865	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KAF59_09885	COG1012	belongs to the aldehyde dehydrogenase family
KAF59_09940	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
KAF59_09945	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KAF59_09950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KAF59_09970	COG3051	citrate lyase alpha subunit
KAF59_09975	COG2301	Belongs to the HpcH HpaI aldolase family
KAF59_09985	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
KAF59_09995	COG3630	sodium ion export across plasma membrane
KAF59_10000	COG0511	ligase activity, forming carbon-carbon bonds
KAF59_10000	COG5016	pyruvate
KAF59_10005	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
KAF59_10015	COG4565	transcriptional regulatory protein
KAF59_10030	COG0583	DNA-binding transcription factor activity
KAF59_10040	COG1115	amino acid carrier protein
KAF59_10045	COG2015	COG2015, Alkyl sulfatase and related hydrolases
KAF59_10050	COG0583	DNA-binding transcription factor activity
KAF59_10060	COG1120	ATPase activity
KAF59_10065	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KAF59_10070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KAF59_10075	COG4592	Periplasmic binding protein
KAF59_10085	COG1028	Short-chain dehydrogenase reductase Sdr
KAF59_10090	COG1169	isochorismate synthase
KAF59_10095	COG1021	2,3-dihydroxybenzoate-AMP ligase
KAF59_10100	COG1535	isochorismatase
KAF59_10100	COG3433	isochorismatase activity
KAF59_10105	COG1584	GPR1 FUN34 yaaH family protein
KAF59_10115	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KAF59_10115	COG0519	Catalyzes the synthesis of GMP from XMP
KAF59_10120	COG0516	GMP reductase activity
KAF59_10120	COG0517	IMP dehydrogenase activity
KAF59_10125	COG1570	exodeoxyribonuclease VII activity
KAF59_10140	COG1160	GTP binding
KAF59_10145	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KAF59_10150	COG2976	Protein conserved in bacteria
KAF59_10155	COG0124	histidyl-tRNA synthetase
KAF59_10160	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KAF59_10170	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KAF59_10175	COG0105	UTP biosynthetic process
KAF59_10180	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KAF59_10185	COG2975	iron-sulfur cluster assembly
KAF59_10190	COG0633	Ferredoxin
KAF59_10195	COG0443	Heat shock 70 kDa protein
KAF59_10200	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KAF59_10210	COG0822	iron-sulfur transferase activity
KAF59_10215	COG1104	cysteine desulfurase activity
KAF59_10220	COG1959	2 iron, 2 sulfur cluster binding
KAF59_10230	COG0483	inositol monophosphate 1-phosphatase activity
KAF59_10235	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KAF59_10240	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KAF59_10245	COG1862	Preprotein translocase
KAF59_10260	COG0517	IMP dehydrogenase activity
KAF59_10270	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KAF59_10275	COG0583	DNA-binding transcription factor activity
KAF59_10280	COG0450	alkyl hydroperoxide reductase
KAF59_10285	COG3142	Participates in the control of copper homeostasis
KAF59_10300	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KAF59_10305	COG0581	inorganic phosphate transmembrane transporter activity
KAF59_10315	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KAF59_10320	COG0248	Ppx GppA phosphatase
KAF59_10330	COG5002	protein histidine kinase activity
KAF59_10335	COG0745	RESPONSE REGULATOR receiver
KAF59_10345	COG0826	peptidase U32
KAF59_10350	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KAF59_10390	COG0542	response to heat
KAF59_10400	COG0564	pseudouridine synthase activity
KAF59_10405	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KAF59_10410	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KAF59_10415	COG0077	Prephenate dehydratase
KAF59_10415	COG1605	Chorismate mutase
KAF59_10420	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KAF59_10425	COG5001	Diguanylate cyclase
KAF59_10435	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
KAF59_10445	COG0488	(ABC) transporter
KAF59_10455	COG0287	Prephenate dehydrogenase
KAF59_10455	COG1605	Chorismate mutase
KAF59_10460	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KAF59_10465	COG3275	phosphorelay sensor kinase activity
KAF59_10470	COG3279	Response regulator of the LytR AlgR family
KAF59_10480	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
KAF59_10485	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KAF59_10500	COG1966	Carbon starvation protein
KAF59_10505	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KAF59_10510	COG1047	Peptidyl-prolyl cis-trans
KAF59_10525	COG0196	riboflavin kinase activity
KAF59_10530	COG0728	peptidoglycan biosynthetic process
KAF59_10535	COG0268	Binds directly to 16S ribosomal RNA
KAF59_10540	COG0640	Transcriptional regulator
KAF59_10545	COG0583	DNA-binding transcription factor activity
KAF59_10550	COG1283	sodium-dependent phosphate transmembrane transporter activity
KAF59_10560	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KAF59_10565	COG0730	response to heat
KAF59_10570	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
KAF59_10575	COG0494	nUDIX hydrolase
KAF59_10585	COG0667	Aldo Keto reductase
KAF59_10595	COG2204	response regulator
KAF59_10600	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KAF59_10620	COG0513	Belongs to the DEAD box helicase family
KAF59_10685	COG2205	protein histidine kinase activity
KAF59_10685	COG3437	response regulator, receiver
KAF59_10685	COG3850	Histidine kinase
KAF59_10685	COG4999	Histidine kinase
KAF59_10710	COG2003	Belongs to the UPF0758 family
KAF59_10735	COG0714	Associated with various cellular activities
KAF59_10755	COG0629	single-stranded DNA binding
KAF59_10770	COG2356	endonuclease I
KAF59_10805	COG0681	Belongs to the peptidase S26 family
KAF59_10820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KAF59_10865	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
KAF59_10895	COG1196	nuclear chromosome segregation
KAF59_10960	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KAF59_11025	COG3153	acetyltransferase
KAF59_11030	COG3154	lipid carrier protein
KAF59_11040	COG0826	peptidase U32
KAF59_11045	COG0826	peptidase U32
KAF59_11070	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KAF59_11080	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KAF59_11085	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KAF59_11090	COG0195	Participates in both transcription termination and antitermination
KAF59_11095	COG0779	Required for maturation of 30S ribosomal subunits
KAF59_11110	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KAF59_11120	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KAF59_11125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KAF59_11130	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
KAF59_11135	COG1534	Rna-binding protein
KAF59_11140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KAF59_11145	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
KAF59_11150	COG2027	D-alanyl-D-alanine carboxypeptidase
KAF59_11155	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KAF59_11160	COG0739	heme binding
KAF59_11175	COG0316	Belongs to the HesB IscA family
KAF59_11180	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KAF59_11185	COG0628	permease
KAF59_11190	COG2813	Specifically methylates the guanine in position
KAF59_11195	COG2205	protein histidine kinase activity
KAF59_11195	COG0784	Response regulator, receiver
KAF59_11200	COG0747	negative chemotaxis
KAF59_11205	COG0601	transmembrane transport
KAF59_11210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KAF59_11215	COG0444	Belongs to the ABC transporter superfamily
KAF59_11220	COG4608	Belongs to the ABC transporter superfamily
KAF59_11230	COG2971	BadF BadG BcrA BcrD
KAF59_11250	COG3842	ATPase activity
KAF59_11260	COG1840	ABC-type Fe3 transport system, periplasmic component
KAF59_11265	COG0004	ammonium transporteR
KAF59_11270	COG0347	Belongs to the P(II) protein family
KAF59_11275	COG3112	Uncharacterised protein family (UPF0231)
KAF59_11280	COG1049	propionate catabolic process, 2-methylcitrate cycle
KAF59_11285	COG1752	Esterase of the alpha-beta hydrolase superfamily
KAF59_11290	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KAF59_11295	COG1643	Atp-dependent helicase
KAF59_11305	COG1489	DNA binding
KAF59_11315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KAF59_11325	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KAF59_11330	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KAF59_11335	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KAF59_11340	COG0842	Transport permease protein
KAF59_11345	COG1131	(ABC) transporter
KAF59_11350	COG0659	secondary active sulfate transmembrane transporter activity
KAF59_11355	COG0288	reversible hydration of carbon dioxide
KAF59_11370	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KAF59_11375	COG3107	peptidoglycan biosynthetic process
KAF59_11380	COG0792	nuclease activity
KAF59_11385	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
KAF59_11390	COG2823	Periplasmic or secreted lipoprotein
KAF59_11395	COG2969	positive regulation of protein catabolic process
KAF59_11400	COG0625	glutathione transferase activity
KAF59_11405	COG2857	Cytochrome c1
KAF59_11410	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KAF59_11415	COG0723	plastoquinol--plastocyanin reductase activity
KAF59_11420	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KAF59_11425	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KAF59_11430	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KAF59_11440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KAF59_11445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KAF59_11450	COG0335	large ribosomal subunit rRNA binding
KAF59_11455	COG0336	Belongs to the RNA methyltransferase TrmD family
KAF59_11460	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KAF59_11465	COG0228	four-way junction DNA binding
KAF59_11470	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KAF59_11475	COG4137	Cytochrome C assembly protein
KAF59_11480	COG4536	flavin adenine dinucleotide binding
KAF59_11485	COG1854	S-ribosylhomocysteine lyase activity
KAF59_11490	COG2918	glutathione biosynthetic process
KAF59_11495	COG0612	Peptidase, M16
KAF59_11500	COG1238	metal cluster binding
KAF59_11510	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
KAF59_11520	COG3630	sodium ion export across plasma membrane
KAF59_11565	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
KAF59_11570	COG0527	aspartate kinase activity
KAF59_11575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KAF59_11585	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KAF59_11595	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KAF59_11600	COG4208	sulfate ABC transporter
KAF59_11620	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KAF59_11625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KAF59_11635	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KAF59_11640	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KAF59_11645	COG0585	pseudouridine synthase activity
KAF59_11650	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KAF59_11655	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KAF59_11660	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
KAF59_11665	COG1968	undecaprenyl-diphosphatase activity
KAF59_11670	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KAF59_11675	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KAF59_11680	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KAF59_11690	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KAF59_11695	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KAF59_11700	COG1610	YqeY-like protein
KAF59_11705	COG0358	DNA primase activity
KAF59_11720	COG0582	viral genome integration into host DNA
KAF59_11725	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
KAF59_11730	COG0840	transmembrane signaling receptor activity
KAF59_11735	COG2207	Transcriptional regulator
KAF59_11740	COG0840	transmembrane signaling receptor activity
KAF59_11750	COG2003	Belongs to the UPF0758 family
KAF59_11780	COG0739	heme binding
KAF59_11790	COG4969	Belongs to the N-Me-Phe pilin family
KAF59_11805	COG0328	RNA-DNA hybrid ribonuclease activity
KAF59_11855	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
KAF59_11860	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KAF59_11865	COG1349	DNA-binding transcription factor activity
KAF59_11885	COG1279	arginine transmembrane transporter activity
KAF59_11890	COG0668	transmembrane transport
KAF59_11895	COG0191	fructose-bisphosphate aldolase activity
KAF59_11900	COG0126	phosphoglycerate kinase activity
KAF59_11905	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KAF59_11910	COG4771	TonB-dependent receptor
KAF59_11915	COG0583	DNA-binding transcription factor activity
KAF59_11920	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KAF59_11925	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KAF59_11935	COG2356	endonuclease I
KAF59_11940	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KAF59_11945	COG0189	ligase activity
KAF59_11950	COG1678	Uncharacterized ACR, COG1678
KAF59_11955	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KAF59_11960	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KAF59_11980	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KAF59_11985	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KAF59_11990	COG0762	integral membrane protein
KAF59_11995	COG1872	DUF167
KAF59_12005	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KAF59_12010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KAF59_12015	COG2066	Belongs to the glutaminase family
KAF59_12025	COG1194	a g-specific adenine glycosylase
KAF59_12030	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
KAF59_12035	COG0741	lytic transglycosylase activity
KAF59_12090	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KAF59_12095	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
KAF59_12100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KAF59_12105	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KAF59_12110	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KAF59_12115	COG2967	ApaG domain
KAF59_12120	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KAF59_12130	COG3610	response to peptide
KAF59_12135	COG2966	Psort location CytoplasmicMembrane, score
KAF59_12140	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KAF59_12145	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KAF59_12150	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KAF59_12155	COG0142	geranyltranstransferase activity
KAF59_12165	COG0039	L-malate dehydrogenase activity
KAF59_12170	COG1438	arginine binding
KAF59_12175	COG2358	TRAP transporter, solute receptor (TAXI family
KAF59_12185	COG0589	response to stress
KAF59_12205	COG2235	arginine
KAF59_12210	COG0312	modulator of DNA gyrase
KAF59_12215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KAF59_12220	COG3164	Protein of unknown function
KAF59_12230	COG0424	maF-like protein
KAF59_12235	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
KAF59_12240	COG1792	Involved in formation and maintenance of cell shape
KAF59_12245	COG1077	Cell shape determining protein MreB Mrl
KAF59_12275	COG2165	general secretion pathway protein
KAF59_12280	COG2165	general secretion pathway protein
KAF59_12290	COG1459	type II secretion system
KAF59_12295	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KAF59_12305	COG3409	Peptidoglycan-binding domain 1 protein
KAF59_12305	COG3267	Type II secretory pathway component ExeA
KAF59_12330	COG2199	diguanylate cyclase activity
KAF59_12330	COG2200	EAL domain
KAF59_12335	COG0629	single-stranded DNA binding
KAF59_12350	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KAF59_12360	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KAF59_12365	COG0527	aspartate kinase activity
KAF59_12370	COG0646	methionine synthase
KAF59_12370	COG1410	methionine synthase
KAF59_12440	COG0175	sulfate reduction
KAF59_12450	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KAF59_12475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KAF59_12480	COG0735	belongs to the Fur family
KAF59_12500	COG0432	Pfam Uncharacterised protein family UPF0047
KAF59_12505	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KAF59_12520	COG0359	binds to the 23S rRNA
KAF59_12525	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KAF59_12530	COG2965	DNA replication, synthesis of RNA primer
KAF59_12535	COG0360	Binds together with S18 to 16S ribosomal RNA
KAF59_12545	COG2906	2 iron, 2 sulfur cluster binding
KAF59_12550	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KAF59_12555	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KAF59_12560	COG0049	tRNA binding
KAF59_12575	COG2923	Belongs to the DsrF TusC family
KAF59_12580	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
KAF59_12585	COG2964	Protein conserved in bacteria
KAF59_12590	COG0545	Peptidyl-prolyl cis-trans isomerase
KAF59_12600	COG2900	Belongs to the SlyX family
KAF59_12605	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
KAF59_12610	COG0330	HflC and HflK could
KAF59_12615	COG0330	HflC and HflK could
KAF59_12620	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KAF59_12625	COG1923	regulation of RNA biosynthetic process
KAF59_12630	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KAF59_12635	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KAF59_12645	COG0802	atpase or kinase
KAF59_12650	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KAF59_12695	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KAF59_12700	COG1162	GTPase activity
KAF59_12705	COG0688	phosphatidylethanolamine metabolic process
KAF59_12710	COG0471	metal ion transport
KAF59_12720	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KAF59_12725	COG4942	peptidase
KAF59_12740	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KAF59_12745	COG2816	NAD+ diphosphatase activity
KAF59_12750	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
KAF59_12755	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KAF59_12760	COG0085	RNA polymerase activity
KAF59_12765	COG0222	ribosome binding
KAF59_12770	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KAF59_12780	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KAF59_12785	COG0250	Participates in transcription elongation, termination and antitermination
KAF59_12790	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KAF59_12795	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KAF59_12820	COG1072	(Pantothenic acid kinase))
KAF59_12830	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KAF59_12840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KAF59_12885	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
KAF59_12900	COG3118	belongs to the thioredoxin family
KAF59_12905	COG0513	Belongs to the DEAD box helicase family
KAF59_12910	COG0248	Ppx GppA phosphatase
KAF59_12915	COG0784	Response regulator, receiver
KAF59_12915	COG2205	protein histidine kinase activity
KAF59_12920	COG2814	Major facilitator Superfamily
KAF59_12935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KAF59_12940	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KAF59_12945	COG0511	ligase activity, forming carbon-carbon bonds
KAF59_12950	COG0439	Biotin carboxylase
KAF59_12955	COG2264	protein methyltransferase activity
KAF59_12960	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KAF59_12965	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
KAF59_12970	COG1609	Transcriptional regulator
KAF59_12975	COG0129	dihydroxy-acid dehydratase activity
KAF59_12980	COG3265	gluconokinase activity
KAF59_12990	COG0800	Aldolase
KAF59_13010	COG0840	transmembrane signaling receptor activity
KAF59_13015	COG1982	Orn Lys Arg decarboxylase major
KAF59_13020	COG0531	amino acid
KAF59_13025	COG3710	Transcriptional regulator
KAF59_13030	COG0789	Transcriptional regulator
KAF59_13045	COG0151	Belongs to the GarS family
KAF59_13055	COG0776	regulation of translation
KAF59_13060	COG1253	flavin adenine dinucleotide binding
KAF59_13065	COG3068	Protein conserved in bacteria
KAF59_13075	COG0668	transmembrane transport
KAF59_13090	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
KAF59_13110	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KAF59_13125	COG0662	Cupin 2, conserved barrel domain protein
KAF59_13125	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
KAF59_13130	COG0438	transferase activity, transferring glycosyl groups
KAF59_13135	COG0367	asparagine synthase
KAF59_13145	COG1216	Glycosyl transferase, family 2
KAF59_13150	COG1215	transferase activity, transferring glycosyl groups
KAF59_13175	COG1051	belongs to the nudix hydrolase family
KAF59_13195	COG5433	transposase activity
KAF59_13230	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KAF59_13240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KAF59_13275	COG1519	Transferase
KAF59_13305	COG3642	lipopolysaccharide core region biosynthetic process
KAF59_13310	COG0859	PFAM glycosyl transferase family 9
KAF59_13315	COG0463	Glycosyl transferase, family 2
KAF59_13320	COG0859	PFAM glycosyl transferase family 9
KAF59_13325	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KAF59_13330	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KAF59_13340	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KAF59_13345	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KAF59_13350	COG2003	Belongs to the UPF0758 family
KAF59_13360	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KAF59_13370	COG1309	transcriptional regulator
KAF59_13375	COG1560	Kdo2-lipid A biosynthetic process
KAF59_13380	COG1560	Kdo2-lipid A biosynthetic process
KAF59_13385	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KAF59_13390	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KAF59_13395	COG1561	YicC-like family, N-terminal region
KAF59_13400	COG2862	Uncharacterized protein family, UPF0114
KAF59_13405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KAF59_13405	COG1263	PTS System
KAF59_13410	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KAF59_13430	COG1120	ATPase activity
KAF59_13435	COG4774	siderophore transport
KAF59_13440	COG1132	(ABC) transporter
KAF59_13455	COG0514	ATP-dependent DNA helicase (RecQ)
KAF59_13460	COG2962	Rard protein
KAF59_13475	COG1280	lysine exporter protein (LysE YggA)
KAF59_13480	COG0210	DNA helicase
KAF59_13490	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
KAF59_13495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KAF59_13535	COG3621	Patatin-like phospholipase
KAF59_13560	COG2131	deaminase
KAF59_13570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KAF59_13575	COG0601	transmembrane transport
KAF59_13580	COG0747	negative chemotaxis
KAF59_13630	COG1309	transcriptional regulator
KAF59_13635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KAF59_13640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KAF59_13645	COG2960	long-chain fatty acid transporting porin activity
KAF59_13650	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KAF59_13655	COG0583	DNA-binding transcription factor activity
KAF59_13700	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
KAF59_13705	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KAF59_13710	COG1739	Uncharacterized protein family UPF0029
KAF59_13720	COG0183	Belongs to the thiolase family
KAF59_13725	COG0583	DNA-binding transcription factor activity
KAF59_13730	COG2814	Major facilitator Superfamily
KAF59_13735	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KAF59_13740	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KAF59_13745	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KAF59_13750	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KAF59_13755	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KAF59_13760	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KAF59_13765	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KAF59_13775	COG0356	it plays a direct role in the translocation of protons across the membrane
KAF59_13780	COG3312	ion transport
KAF59_13785	COG1475	DNA binding
KAF59_13790	COG1192	Involved in chromosome partitioning
KAF59_13800	COG0445	tRNA wobble uridine modification
KAF59_13805	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KAF59_13810	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KAF59_13815	COG0706	membrane insertase activity
KAF59_13825	COG0594	ribonuclease P activity
KAF59_13830	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KAF59_13835	COG1126	abc transporter atp-binding protein
KAF59_13880	COG0217	transcriptional regulatory protein
KAF59_13885	COG2084	Dehydrogenase
KAF59_13905	COG0058	SHG alpha-glucan phosphorylase activity
KAF59_13910	COG1640	4-alpha-glucanotransferase
KAF59_13915	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KAF59_13925	COG3501	Rhs element vgr protein
KAF59_13930	COG4104	PAAR repeat-containing protein
KAF59_13960	COG0471	metal ion transport
KAF59_13965	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
KAF59_14005	COG0671	phosphoesterase, PA-phosphatase related
KAF59_14010	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
KAF59_14020	COG1999	signal sequence binding
KAF59_14035	COG0786	glutamate:sodium symporter activity
KAF59_14055	COG1566	PFAM secretion protein HlyD family protein
KAF59_14080	COG0813	purine-nucleoside phosphorylase activity
KAF59_14085	COG3272	Protein of unknown function (DUF1722)
KAF59_14095	COG0415	Belongs to the DNA photolyase family
KAF59_14100	COG1376	ErfK ybiS ycfS ynhG family protein
KAF59_14100	COG1388	LysM domain
KAF59_14110	COG0513	Belongs to the DEAD box helicase family
KAF59_14115	COG1770	oligopeptidase
KAF59_14145	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KAF59_14150	COG0573	inorganic phosphate transmembrane transporter activity
KAF59_14155	COG0581	inorganic phosphate transmembrane transporter activity
KAF59_14160	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KAF59_14175	COG3314	Sporulation integral membrane protein YlbJ
KAF59_14180	COG0659	secondary active sulfate transmembrane transporter activity
KAF59_14190	COG0739	heme binding
KAF59_14195	COG5001	Diguanylate cyclase
KAF59_14195	COG3300	MHYT domain
KAF59_14200	COG0583	DNA-binding transcription factor activity
KAF59_14205	COG2814	Major facilitator Superfamily
KAF59_14225	COG1301	dicarboxylic acid transport
KAF59_14235	COG1342	Belongs to the UPF0251 family
KAF59_14265	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KAF59_14270	COG0673	inositol 2-dehydrogenase activity
KAF59_14280	COG2200	EAL domain
KAF59_14280	COG2771	luxR family
KAF59_14285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KAF59_14295	COG0564	pseudouridine synthase activity
KAF59_14360	COG3829	transcription factor binding
KAF59_14385	COG3501	Rhs element vgr protein
KAF59_14385	COG3409	Peptidoglycan-binding domain 1 protein
KAF59_14400	COG1869	D-ribose catabolic process
KAF59_14405	COG1129	ABC transporter
KAF59_14410	COG1172	Belongs to the binding-protein-dependent transport system permease family
KAF59_14415	COG1879	ABC-type sugar transport system periplasmic component
KAF59_14420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KAF59_14425	COG1609	Transcriptional regulator
KAF59_14435	COG3201	nicotinamide mononucleotide transporter
KAF59_14440	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
KAF59_14450	COG0584	glycerophosphoryl diester phosphodiesterase
KAF59_14455	COG2271	Major facilitator Superfamily
KAF59_14490	COG0579	oxidoreductase
KAF59_14500	COG0242	peptide deformylase activity
KAF59_14510	COG1320	monovalent cation:proton antiporter activity
KAF59_14515	COG2212	antiporter activity
KAF59_14520	COG1863	multisubunit Na H antiporter MnhE subunit
KAF59_14525	COG0651	ATP synthesis coupled electron transport
KAF59_14530	COG1006	Multisubunit Na H antiporter MnhC subunit
KAF59_14535	COG2111	Na H antiporter
KAF59_14535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KAF59_14545	COG0589	response to stress
KAF59_14550	COG0814	amino acid
KAF59_14565	COG3530	Putative quorum-sensing-regulated virulence factor
KAF59_14575	COG5001	Diguanylate cyclase
KAF59_14575	COG5002	protein histidine kinase activity
KAF59_14580	COG1278	Cold shock
KAF59_14595	COG2304	oxidoreductase activity
KAF59_14615	COG0714	Associated with various cellular activities
KAF59_14620	COG0840	transmembrane signaling receptor activity
KAF59_14635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KAF59_14640	COG2195	Cleaves the N-terminal amino acid of tripeptides
KAF59_14650	COG3604	Transcriptional regulator
KAF59_14655	COG1017	nitric oxide dioxygenase activity
KAF59_14655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KAF59_14660	COG1278	Cold shock
KAF59_14665	COG3036	rescue of stalled ribosome
KAF59_14690	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KAF59_14690	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KAF59_14695	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KAF59_14705	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KAF59_14715	COG0516	GMP reductase activity
KAF59_14750	COG0513	Belongs to the DEAD box helicase family
KAF59_14755	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KAF59_14760	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KAF59_14765	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KAF59_14770	COG3437	response regulator, receiver
KAF59_14770	COG0784	Response regulator, receiver
KAF59_14775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KAF59_14775	COG4191	Histidine kinase
KAF59_14785	COG1757	Na H antiporter
KAF59_14790	COG2814	Major facilitator Superfamily
KAF59_14800	COG3706	GGDEF domain
KAF59_14805	COG3240	lipase activity
KAF59_14815	COG0840	transmembrane signaling receptor activity
KAF59_14820	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
KAF59_14825	COG5380	lipid catabolic process
KAF59_14850	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KAF59_14855	COG4605	iron ion homeostasis
KAF59_14860	COG4604	ABC transporter, ATP-binding protein
KAF59_14865	COG2207	Transcriptional regulator
KAF59_14880	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KAF59_14900	COG0745	RESPONSE REGULATOR receiver
KAF59_14910	COG3623	hexulose-6-phosphate isomerase
KAF59_14915	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
KAF59_14920	COG0561	phosphatase activity
KAF59_14950	COG3038	cytochrome b561
KAF59_14955	COG0366	Alpha amylase catalytic
KAF59_14980	COG0745	RESPONSE REGULATOR receiver
KAF59_14985	COG5002	protein histidine kinase activity
KAF59_15010	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KAF59_15025	COG2814	Major facilitator Superfamily
KAF59_15040	COG1686	Belongs to the peptidase S11 family
KAF59_15065	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KAF59_15065	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KAF59_15070	COG0509	glycine decarboxylation via glycine cleavage system
KAF59_15075	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KAF59_15085	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KAF59_15095	COG3039	Transposase
KAF59_15130	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KAF59_15135	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KAF59_15185	COG1028	Short-chain dehydrogenase reductase Sdr
KAF59_15220	COG0232	Belongs to the dGTPase family. Type 2 subfamily
KAF59_15245	COG0494	nUDIX hydrolase
KAF59_15260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KAF59_15265	COG3040	lipid binding
KAF59_15295	COG3041	Addiction module toxin RelE StbE family
KAF59_15390	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KAF59_15400	COG1280	lysine exporter protein (LysE YggA)
KAF59_15585	COG3549	Plasmid maintenance system killer
KAF59_15590	COG3093	addiction module antidote protein HigA
KAF59_15610	COG1619	proteins homologs of microcin C7 resistance protein MccF
KAF59_15635	COG3040	lipid binding
KAF59_15690	COG4977	sequence-specific DNA binding
KAF59_15770	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
KAF59_15775	COG2944	sequence-specific DNA binding
KAF59_15790	COG3039	Transposase
KAF59_15815	COG0346	lactoylglutathione lyase activity
KAF59_15960	COG0346	lactoylglutathione lyase activity
KAF59_15975	COG1328	CTP reductase activity
KAF59_15980	COG0602	queuosine metabolic process
KAF59_15990	COG4067	protein conserved in archaea
KAF59_15990	COG0189	ligase activity
KAF59_15995	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KAF59_15995	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KAF59_15995	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
KAF59_16000	COG1105	Belongs to the carbohydrate kinase PfkB family
KAF59_16005	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KAF59_16005	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KAF59_16010	COG1609	Transcriptional regulator
KAF59_16015	COG0420	3'-5' exonuclease activity
KAF59_16020	COG0419	ATPase involved in DNA repair
KAF59_16025	COG0784	Response regulator, receiver
KAF59_16025	COG2205	protein histidine kinase activity
KAF59_16030	COG0156	8-amino-7-oxononanoate synthase activity
KAF59_16045	COG0523	cobalamin synthesis protein
KAF59_16060	COG0674	pyruvate-flavodoxin oxidoreductase activity
KAF59_16060	COG1013	pyruvate-flavodoxin oxidoreductase activity
KAF59_16060	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KAF59_16060	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KAF59_16065	COG2205	protein histidine kinase activity
KAF59_16070	COG0745	RESPONSE REGULATOR receiver
KAF59_16075	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KAF59_16080	COG0586	Pfam SNARE associated Golgi protein
KAF59_16090	COG2200	EAL domain
KAF59_16100	COG3038	cytochrome b561
KAF59_16110	COG2116	formate transmembrane transporter activity
KAF59_16115	COG0583	DNA-binding transcription factor activity
KAF59_16125	COG3593	DNA synthesis involved in DNA repair
KAF59_16130	COG0737	Belongs to the 5'-nucleotidase family
KAF59_16145	COG2824	Alkylphosphonate utilization operon protein PhnA
KAF59_16175	COG2199	diguanylate cyclase activity
KAF59_16195	COG3706	GGDEF domain
KAF59_16210	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
KAF59_16215	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
KAF59_16225	COG0745	RESPONSE REGULATOR receiver
KAF59_16240	COG3140	Belongs to the UPF0181 family
KAF59_16245	COG0023	Translation Initiation Factor
KAF59_16265	COG1042	CoA-binding domain protein
KAF59_16265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KAF59_16265	COG0045	succinate-CoA ligase (ADP-forming) activity
KAF59_16270	COG0583	DNA-binding transcription factor activity
KAF59_16275	COG1629	transport
KAF59_16275	COG4771	TonB-dependent receptor
KAF59_16290	COG2050	protein possibly involved in aromatic compounds catabolism
KAF59_16310	COG0625	glutathione transferase activity
KAF59_16325	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KAF59_16330	COG4172	Belongs to the ABC transporter superfamily
KAF59_16335	COG4239	(ABC) transporter, permease
KAF59_16340	COG4174	ABC transporter (Permease)
KAF59_16345	COG4166	transmembrane transport
KAF59_16370	COG3104	oligopeptide transport
KAF59_16390	COG3842	ATPase activity
KAF59_16400	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KAF59_16405	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KAF59_16410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KAF59_16415	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KAF59_16420	COG1011	Hydrolase
KAF59_16430	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
KAF59_16435	COG1970	mechanosensitive ion channel activity
KAF59_16440	COG2759	Belongs to the formate--tetrahydrofolate ligase family
KAF59_16445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KAF59_16445	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KAF59_16450	COG0302	gtp cyclohydrolase
KAF59_16460	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KAF59_16470	COG2897	thiosulfate sulfurtransferase activity
KAF59_16475	COG2390	Transcriptional regulator
KAF59_16485	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KAF59_16510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KAF59_16535	COG0583	DNA-binding transcription factor activity
KAF59_16540	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
KAF59_16580	COG0446	pyridine nucleotide-disulphide oxidoreductase
KAF59_16625	COG1263	PTS System
KAF59_16625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KAF59_16630	COG1609	Transcriptional regulator
KAF59_16635	COG1621	beta-fructofuranosidase activity
KAF59_16640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KAF59_16645	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KAF59_16655	COG2885	chlorophyll binding
KAF59_16660	COG0545	Peptidyl-prolyl cis-trans isomerase
KAF59_16665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KAF59_16670	COG0840	transmembrane signaling receptor activity
KAF59_16675	COG3069	C4-dicarboxylate transmembrane transporter activity
KAF59_16680	COG1760	l-serine dehydratase
KAF59_16700	COG1609	Transcriptional regulator
KAF59_16705	COG2197	response regulator
KAF59_16710	COG3850	Histidine kinase
KAF59_16715	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KAF59_16725	COG0243	molybdopterin cofactor binding
KAF59_16745	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
KAF59_16750	COG2197	response regulator
KAF59_16755	COG3851	Histidine kinase
KAF59_16760	COG2271	Major facilitator Superfamily
KAF59_16765	COG1840	ABC-type Fe3 transport system, periplasmic component
KAF59_16775	COG3842	ATPase activity
KAF59_16780	COG3243	poly(R)-hydroxyalkanoic acid synthase
KAF59_16790	COG0183	Belongs to the thiolase family
KAF59_16800	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KAF59_16805	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KAF59_16825	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KAF59_16835	COG1979	alcohol dehydrogenase
KAF59_16850	COG4191	Histidine kinase
KAF59_16860	COG2271	Major facilitator Superfamily
KAF59_16865	COG0469	pyruvate kinase activity
KAF59_16870	COG0784	Response regulator, receiver
KAF59_16870	COG2198	Histidine kinase
KAF59_16870	COG2205	protein histidine kinase activity
KAF59_16875	COG1879	ABC-type sugar transport system periplasmic component
KAF59_16880	COG1803	Methylglyoxal synthase
KAF59_16885	COG1335	isochorismatase
KAF59_16890	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KAF59_16905	COG0210	DNA helicase
KAF59_16910	COG1289	transmembrane transporter activity
KAF59_16940	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
KAF59_16945	COG4149	molybdate abc transporter
KAF59_16950	COG0725	ABC transporter, periplasmic molybdate-binding protein
KAF59_16955	COG1492	cobalamin metabolic process
KAF59_16995	COG0784	Response regulator, receiver
KAF59_16995	COG5002	protein histidine kinase activity
KAF59_17000	COG1879	ABC-type sugar transport system periplasmic component
KAF59_17010	COG2827	Endonuclease containing a URI domain
KAF59_17025	COG2926	Belongs to the UPF0265 family
KAF59_17035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KAF59_17040	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KAF59_17045	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KAF59_17050	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
KAF59_17055	COG0247	lactate metabolic process
KAF59_17060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KAF59_17065	COG3118	belongs to the thioredoxin family
KAF59_17095	COG0583	DNA-binding transcription factor activity
KAF59_17100	COG4160	amino acid transport
KAF59_17105	COG4215	(ABC) transporter
KAF59_17110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KAF59_17115	COG1126	abc transporter atp-binding protein
KAF59_17125	COG2425	protein containing a von Willebrand factor type A (vWA) domain
KAF59_17135	COG0494	nUDIX hydrolase
KAF59_17140	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
KAF59_17150	COG1309	transcriptional regulator
KAF59_17155	COG0513	Belongs to the DEAD box helicase family
KAF59_17160	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
KAF59_17165	COG0814	amino acid
KAF59_17170	COG0840	transmembrane signaling receptor activity
KAF59_17175	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KAF59_17180	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
KAF59_17190	COG1984	allophanate hydrolase subunit 2
KAF59_17205	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
KAF59_17210	COG4181	ATPase activity
KAF59_17220	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KAF59_17225	COG1716	ATPase activity
KAF59_17225	COG5001	Diguanylate cyclase
KAF59_17235	COG0484	heat shock protein binding
KAF59_17275	COG0546	phosphoglycolate phosphatase activity
KAF59_17290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KAF59_17295	COG1368	sulfuric ester hydrolase activity
KAF59_17305	COG0513	Belongs to the DEAD box helicase family
KAF59_17320	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KAF59_17330	COG3046	protein related to deoxyribodipyrimidine photolyase
KAF59_17335	COG3397	chitin binding
KAF59_17340	COG3227	Zinc metalloprotease (Elastase)
KAF59_17350	COG0010	Belongs to the arginase family
KAF59_17355	COG1166	arginine decarboxylase activity
KAF59_17365	COG2239	Acts as a magnesium transporter
KAF59_17370	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KAF59_17375	COG0459	protein refolding
KAF59_17385	COG0527	aspartate kinase activity
KAF59_17390	COG0662	Cupin 2, conserved barrel domain protein
KAF59_17395	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KAF59_17400	COG0456	acetyltransferase
KAF59_17410	COG3186	Phenylalanine-4-hydroxylase
KAF59_17415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KAF59_17430	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KAF59_17455	COG1253	flavin adenine dinucleotide binding
KAF59_17460	COG1765	OsmC-like protein
KAF59_17485	COG0531	amino acid
KAF59_17500	COG3279	Response regulator of the LytR AlgR family
KAF59_17505	COG3275	phosphorelay sensor kinase activity
KAF59_17520	COG0577	efflux transmembrane transporter activity
KAF59_17520	COG1136	(ABC) transporter
KAF59_17525	COG1136	(ABC) transporter
KAF59_17535	COG4989	oxidoreductase activity
KAF59_17540	COG0366	Alpha amylase catalytic
KAF59_17550	COG2067	long-chain fatty acid transport protein
KAF59_17555	COG2267	carboxylic ester hydrolase activity
KAF59_17565	COG3227	Zinc metalloprotease (Elastase)
KAF59_17575	COG3047	cAMP biosynthetic process
KAF59_17585	COG1686	Belongs to the peptidase S11 family
KAF59_17590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KAF59_17595	COG1271	oxidase subunit
KAF59_17600	COG1294	oxidase, subunit
KAF59_17615	COG3048	D-serine ammonia-lyase activity
KAF59_17620	COG0583	DNA-binding transcription factor activity
KAF59_17665	COG1063	alcohol dehydrogenase
KAF59_17690	COG0346	lactoylglutathione lyase activity
KAF59_17710	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KAF59_17715	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
KAF59_17720	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KAF59_17725	COG0363	glucosamine-6-phosphate deaminase activity
KAF59_17730	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KAF59_17755	COG1929	Belongs to the glycerate kinase type-1 family
KAF59_17760	COG2610	gluconate transmembrane transporter activity
KAF59_17765	COG3835	regulator
KAF59_17775	COG0748	coenzyme F420 binding
KAF59_17780	COG3721	Heme iron utilization protein
KAF59_17790	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
KAF59_17795	COG0811	peptide transport
KAF59_17800	COG0848	biopolymer transport protein
KAF59_17805	COG4558	Periplasmic binding protein
KAF59_17810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KAF59_17815	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
KAF59_17850	COG0633	Ferredoxin
KAF59_17850	COG3217	Mosc domain protein beta barrel domain protein
KAF59_17850	COG0633	Ferredoxin
KAF59_17850	COG3217	Mosc domain protein beta barrel domain protein
KAF59_17855	COG0418	dihydroorotase activity
KAF59_17865	COG3152	Membrane
KAF59_17875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KAF59_17880	COG2354	Protein conserved in bacteria
KAF59_17885	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
KAF59_17890	COG1278	Cold shock
KAF59_17915	COG2199	diguanylate cyclase activity
KAF59_17920	COG1349	DNA-binding transcription factor activity
KAF59_17935	COG3833	ABC-type maltose transport systems, permease component
KAF59_17940	COG1175	transmembrane transport
KAF59_17950	COG3842	ATPase activity
KAF59_17955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KAF59_17970	COG0393	Putative heavy-metal-binding
KAF59_17980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KAF59_17985	COG0784	Response regulator, receiver
KAF59_17985	COG0835	chemotaxis
KAF59_17990	COG1846	Transcriptional regulator
KAF59_17995	COG3706	GGDEF domain
KAF59_18030	COG0583	DNA-binding transcription factor activity
KAF59_18035	COG5001	Diguanylate cyclase
KAF59_18045	COG1741	Belongs to the pirin family
KAF59_18050	COG3123	guanosine phosphorylase activity
KAF59_18060	COG2211	Major facilitator Superfamily
KAF59_18065	COG0840	transmembrane signaling receptor activity
KAF59_18070	COG1067	ATP-dependent peptidase activity
KAF59_18080	COG4172	Belongs to the ABC transporter superfamily
KAF59_18105	COG0583	DNA-binding transcription factor activity
KAF59_18115	COG1620	l-lactate permease
KAF59_18130	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KAF59_18140	COG0840	transmembrane signaling receptor activity
KAF59_18150	COG0513	Belongs to the DEAD box helicase family
KAF59_18155	COG0583	DNA-binding transcription factor activity
KAF59_18165	COG1902	pentaerythritol trinitrate reductase activity
KAF59_18175	COG1132	(ABC) transporter
KAF59_18185	COG1902	pentaerythritol trinitrate reductase activity
KAF59_18195	COG1280	lysine exporter protein (LysE YggA)
KAF59_18200	COG2207	Transcriptional regulator
KAF59_18220	COG1846	Transcriptional regulator
KAF59_18225	COG1764	response to oxidative stress
KAF59_18230	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
KAF59_18235	COG0697	spore germination
KAF59_18245	COG0700	Nucleoside recognition
KAF59_18250	COG3366	ferrous iron transmembrane transporter activity
KAF59_18255	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KAF59_18265	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KAF59_18270	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KAF59_18275	COG2259	Doxx family
KAF59_18300	COG0363	glucosamine-6-phosphate deaminase activity
KAF59_18315	COG4580	involved in the transport of maltose and maltodextrins
KAF59_18330	COG0840	transmembrane signaling receptor activity
KAF59_18345	COG0840	transmembrane signaling receptor activity
KAF59_18355	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KAF59_18360	COG1126	abc transporter atp-binding protein
KAF59_18370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KAF59_18375	COG4597	amino acid ABC transporter
KAF59_18380	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KAF59_18390	COG0739	heme binding
KAF59_18395	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KAF59_18395	COG2213	PTS system mannitol-specific
KAF59_18400	COG0246	Mannitol dehydrogenase
KAF59_18405	COG3722	fumarate hydratase activity
KAF59_18410	COG0673	inositol 2-dehydrogenase activity
KAF59_18440	COG2910	NAD(P)H-binding
KAF59_18450	COG0840	transmembrane signaling receptor activity
KAF59_18455	COG4221	oxidoreductase activity
KAF59_18465	COG1901	pseudouridine methyltransferase
KAF59_18480	COG0531	amino acid
KAF59_18485	COG1982	Orn Lys Arg decarboxylase major
KAF59_18515	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KAF59_18540	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KAF59_18580	COG0745	RESPONSE REGULATOR receiver
KAF59_18605	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KAF59_18610	COG0840	transmembrane signaling receptor activity
KAF59_18615	COG0835	chemotaxis
KAF59_18620	COG0835	chemotaxis
KAF59_18625	COG0643	Histidine kinase
KAF59_18625	COG2198	Histidine kinase
KAF59_18645	COG0601	transmembrane transport
KAF59_18650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KAF59_18660	COG2194	sulfuric ester hydrolase activity
KAF59_18665	COG0642	Histidine kinase
KAF59_18700	COG1444	tRNA N-acetyltransferase activity
KAF59_18705	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine